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Search of human proteins with 47059046
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
(2916 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 5777 0.0
gi|16933557 dachsous 1 precursor [Homo sapiens] 1397 0.0
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 1044 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 863 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 738 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 682 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 668 0.0
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 660 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 399 e-110
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 363 2e-99
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 360 1e-98
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 282 3e-75
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 281 5e-75
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 281 5e-75
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 281 5e-75
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 281 5e-75
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 281 5e-75
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 281 5e-75
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 281 5e-75
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 281 5e-75
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 281 5e-75
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 271 7e-72
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 264 1e-69
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 263 2e-69
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 263 2e-69
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 260 2e-68
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 260 2e-68
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 252 4e-66
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 252 4e-66
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 252 4e-66
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 5777 bits (14987), Expect = 0.0
Identities = 2916/2916 (100%), Positives = 2916/2916 (100%)
Query: 1 MRLDEITKSENEDGEKKMFTQQFESTDACVYEVYVKINSIVKSQSQCGLKRGSPETELWG 60
MRLDEITKSENEDGEKKMFTQQFESTDACVYEVYVKINSIVKSQSQCGLKRGSPETELWG
Sbjct: 1 MRLDEITKSENEDGEKKMFTQQFESTDACVYEVYVKINSIVKSQSQCGLKRGSPETELWG 60
Query: 61 AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 120
AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV
Sbjct: 61 AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 120
Query: 121 SQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPS 180
SQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPS
Sbjct: 121 SQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPS 180
Query: 181 TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI
Sbjct: 181 TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
Query: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK
Sbjct: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
Query: 301 VQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN 360
VQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN
Sbjct: 301 VQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN 360
Query: 361 ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL 420
ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL
Sbjct: 361 ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL 420
Query: 421 GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480
GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF
Sbjct: 421 GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480
Query: 481 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540
LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG
Sbjct: 481 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540
Query: 541 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 600
SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP
Sbjct: 541 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 600
Query: 601 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR
Sbjct: 601 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
Query: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD
Sbjct: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
Query: 721 SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK
Sbjct: 721 SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
Query: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 840
SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP
Sbjct: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 840
Query: 841 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI 900
QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI
Sbjct: 841 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI 900
Query: 901 RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPEN 960
RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPEN
Sbjct: 901 RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPEN 960
Query: 961 LKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY 1020
LKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY
Sbjct: 961 LKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY 1020
Query: 1021 LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK
Sbjct: 1021 LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
Query: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN
Sbjct: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
Query: 1141 VTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVT 1200
VTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVT
Sbjct: 1141 VTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVT 1200
Query: 1201 YSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260
YSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL
Sbjct: 1201 YSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN
Sbjct: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD 1380
SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD 1380
Query: 1381 IEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
IEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQ
Sbjct: 1381 IEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
Query: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL
Sbjct: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
Query: 1501 SAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ 1560
SAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ
Sbjct: 1501 SAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ 1560
Query: 1561 GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF
Sbjct: 1561 GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
Query: 1621 SFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV 1680
SFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV
Sbjct: 1621 SFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV 1680
Query: 1681 KISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQL 1740
KISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQL
Sbjct: 1681 KISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQL 1740
Query: 1741 TVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800
TVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ
Sbjct: 1741 TVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800
Query: 1801 LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSL 1860
LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSL
Sbjct: 1801 LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSL 1860
Query: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDL 1920
IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDL
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDL 1920
Query: 1921 NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVV 1980
NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVV
Sbjct: 1921 NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVV 1980
Query: 1981 RVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDP 2040
RVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDP
Sbjct: 1981 RVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDP 2040
Query: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN
Sbjct: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
Query: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG
Sbjct: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
Query: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK
Sbjct: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
Query: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK 2280
ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK
Sbjct: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK 2280
Query: 2281 FTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD 2340
FTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD
Sbjct: 2281 FTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD 2340
Query: 2341 FDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK 2400
FDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK
Sbjct: 2341 FDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK 2400
Query: 2401 DKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVI 2460
DKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVI
Sbjct: 2401 DKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVI 2460
Query: 2461 LYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVF 2520
LYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVF
Sbjct: 2461 LYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVF 2520
Query: 2521 VNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEEKKTSS 2580
VNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEEKKTSS
Sbjct: 2521 VNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEEKKTSS 2580
Query: 2581 LDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHC 2640
LDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHC
Sbjct: 2581 LDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHC 2640
Query: 2641 SVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTA 2700
SVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTA
Sbjct: 2641 SVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTA 2700
Query: 2701 ETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRC 2760
ETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRC
Sbjct: 2701 ETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRC 2760
Query: 2761 AALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFV 2820
AALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFV
Sbjct: 2761 AALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFV 2820
Query: 2821 FPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLL 2880
FPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLL
Sbjct: 2821 FPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLL 2880
Query: 2881 TMQPPALSPLLREGELLGTHISGTCHELKAEDEVQI 2916
TMQPPALSPLLREGELLGTHISGTCHELKAEDEVQI
Sbjct: 2881 TMQPPALSPLLREGELLGTHISGTCHELKAEDEVQI 2916
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 1397 bits (3617), Expect = 0.0
Identities = 972/2916 (33%), Positives = 1457/2916 (49%), Gaps = 208/2916 (7%)
Query: 54 PETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 113
PE L G+ V R VTA D D G G + YSL G ++ F IDP
Sbjct: 483 PEVALPGSFVVR-------------VTARDPDQGTNGQVTYSLAPGAHTHW----FSIDP 525
Query: 114 HDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDN 173
G I + +D E +P L+V A DG L++ A V V L+DVNDN
Sbjct: 526 TSGIITTAASLDYELEPQP-QLIVVATDGGLPP----------LASSATVSVALQDVNDN 574
Query: 174 HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS---LFTIDST 230
P F + Y S+ + TQPGT + V ATD DSG +G ++Y L G SS F ID+
Sbjct: 575 EPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAH 634
Query: 231 TGLYSPEVEI-----LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRG 285
+G + S+ +F+ L+ + ++ F E D E +
Sbjct: 635 SGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMV-YVKVFLSDENDNPPQFYPREYAAS 693
Query: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKIL-----GEGIIYLTLPLSHLES 340
+ + L+ D + G + +A + L G++ + PL+ +
Sbjct: 694 ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRAN 753
Query: 341 TTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
+ + L + A+DGGGL A +A V I I T P FE+ +Y F V EDV + +G V+
Sbjct: 754 SVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQ 813
Query: 401 AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ-PVVVLTVQAQLGSAP 459
A P P+ +S GD G FS+ G ++T +PLD E PV+ L V+A G P
Sbjct: 814 AHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873
Query: 460 ACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI 519
A + V + + DVNDN PAF D + + T PGT +Y RA D DSG N + +++
Sbjct: 874 AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933
Query: 520 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK--- 576
+ G F +D G + L LG L L A D G P+ + L VV++
Sbjct: 934 LAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGT 993
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGI 636
R +P F Y+V++ + TQ+LQ QA P P+ Y L S+ FG+
Sbjct: 994 RGLAPR--FNSPTYRVDLPSGTTAGTQVLQVQAQ--APD--GGPITYHLAAEGASSPFGL 1047
Query: 637 RPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFLH 694
P +GW+++R D E+ + Y +V A L Q + TV V + ++N++SP
Sbjct: 1048 EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSE 1107
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKFFKMNPNTGPAGTIY 751
D FL V E+ P +G++ A D DSG NG+L Y L D K F+++P TG T+
Sbjct: 1108 DPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQ 1167
Query: 752 VITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLV 811
LDRE + +++ V V
Sbjct: 1168 T--------------------------------------------LDREQQSSYQLLVQV 1183
Query: 812 TDRGSPPRNATMAVYVSVTDINDNRPFFPQC--LPGKELHVKVLEGQPVNMLVTTVFAKD 869
D GSPPR+ T V+V+V D+NDN P F Q G L ++V + P LVTT+ AKD
Sbjct: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKD 1243
Query: 870 PDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ 929
PDEG N + Y+++ S+ F + ++GE+ T L RP Y +++ A DQG PP
Sbjct: 1244 PDEGENGTILYTLTGP-GSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRS 1302
Query: 930 GQAVVNIQVIP---LSKGRAIMSQNIRHLIIP--------ENLKPTKIMSLIKSSDHLQQ 978
+ +QV+P L++ +++ +P E L+P ++ + + +
Sbjct: 1303 ASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGV 1362
Query: 979 HYNGKLHFSIVAD-DKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSS 1037
G L +++V D +G F +D+++G L+L++ LD+E + + + +
Sbjct: 1363 ---GALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAG-AR 1418
Query: 1038 TVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES 1097
+ + + V+D+N+H+P+F + + +++ EN G +Y F A D DG NS ++Y +
Sbjct: 1419 LLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLR 1478
Query: 1098 HNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILD 1157
P + G L LDRE+ P ++L V A+D+ N + RR ++A++ + D
Sbjct: 1479 QEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTD 1538
Query: 1158 VNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDES 1217
ND+ P F S + ED G H+ A DPD G +V+Y + SG + F L S
Sbjct: 1539 ENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSS 1597
Query: 1218 SGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEAS 1277
+G L+ PLD E + +H+LTV+A D G+P S++Q LTV+V DVNDEAP F+Q Y
Sbjct: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL 1657
Query: 1278 VKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQ 1337
++EN PG + + A D D G N ++ + G S E F ++ DTG + T LDRE Q
Sbjct: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQ 1714
Query: 1338 EVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLA 1397
E L V +D G P + T+ VEDENDHAP F + +EV E Q+P+ + + A
Sbjct: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRA 1774
Query: 1398 SDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
SD D G N ++Y I+DG+ F ++ SGE T R LDRE F L I D G P
Sbjct: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL 1517
S+ + L V VLDANDH+P+FP Y V ED GT++L L A D D G NG Y+L
Sbjct: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
Query: 1518 TDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVN 1577
+GAF ++P SG L+T+ LDRE +TFS A D + G STTV + + V DVN
Sbjct: 1895 GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVN 1954
Query: 1578 DNDPVLEQNPFDVFLSPESPTNQTTVI----VRADDLDLGPNGTVVFSFAETQSM-FSID 1632
D+ P +P + L P+ T + +RA+D D G N ++++ A T ++D
Sbjct: 1955 DHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVD 2014
Query: 1633 KYTGEIQFQQNP-SSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVK-ISFSHHLYK 1690
YTGEI+ ++P + L + TD G PAR+ TG++++ ++GE + F +
Sbjct: 2015 SYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSE 2074
Query: 1691 GLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDF 1750
+ EN GT IV+ +A + YSI SGNE G S+ +G +TV+ + LDF
Sbjct: 2075 ATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDF 2134
Query: 1751 EVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVF 1810
EV ++L++ AES G A+ + + +QD NDN+P F + Y A + ES+ ++QV
Sbjct: 2135 EVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVE 2194
Query: 1811 ATDLDSGLNGLIEYSILSGNQEEA-FQIDALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
A DLD G G I YS+ + F +D +G ITT AILD E+ + L++ ATD+G
Sbjct: 2195 ADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGS 2254
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFA 1929
P L + + V V D NDN P + ++ED+L G + V+ +DVD + ++
Sbjct: 2255 PALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD-SGPVLWYVL 2313
Query: 1930 KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNP 1989
S P F++ + G V L LDFE+ Y+L + D H L V V DVNDN
Sbjct: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNA 2373
Query: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPKNGTIFT 2047
P FSQ YQV + E P G ++L++SATD +S N +ISY + S + FS+DP NGT+FT
Sbjct: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFT 2433
Query: 2048 ISPVLLL--DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
I + L D ++EA D G P A V + ++D N++AP FT+ Y ++++E
Sbjct: 2434 IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY----KQVGY 2161
D GSTL+T D D +R + V+YSIISGN F +E + + + +G
Sbjct: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGC 2553
Query: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
LVLL LD E+ + L + A+D G PP SS +++ VLDVNDNPP F+ SY V E
Sbjct: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPE 2613
Query: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKF 2281
TP+G+ + V A+D D G H + + + SG+ G F L+E++G L L LD E +
Sbjct: 2614 DTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARH 2673
Query: 2282 TLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341
L VQA+D HF+ A V + V D NDH P F + S V EN P + + +++A+D
Sbjct: 2674 QLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDG 2733
Query: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401
DAG +G L YS++ G + F ++ TG++ A+ DYE+ + L V A D
Sbjct: 2734 DAGAFGRLRYSLLEAGPGPEG----REAFALNSSTGELRARVPFDYEHTESFRLLVGAAD 2789
Query: 2402 KGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVIL 2461
G+ +AS+ V V + G DE++P+F + F +PE + +G V+A+D D G DG++L
Sbjct: 2790 AGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVL 2849
Query: 2462 YSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDT----------------LEMKIIA 2505
YSL TSSP+F +N+T G +YL + S+ T L +++IA
Sbjct: 2850 YSLATSSPYFGINQTTGALYL-----RVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA 2904
Query: 2506 HSPKSDSKFASCTVFVNVSFSSEGTP-----LAVFASSFSISLVVSFLVFLILICILIVM 2560
P S+ A+ V V+++ ++ G L V A + S+ +VV ++ + L++
Sbjct: 2905 RGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVV-----VLALAALVLG 2959
Query: 2561 ILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLI 2620
++R + + E + + D+ + +E + P +
Sbjct: 2960 LVRARSRKA-----EAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHLYHQTLPSYGGPG 3014
Query: 2621 SIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGI 2680
+ S+SSG S E AED EI+ INE P S+L+ +R PDSGI
Sbjct: 3015 AGGPYPRGGSLDPSHSSGRGS--AEAAEDDEIRMINEFPRVASVASSLA---ARGPDSGI 3069
Query: 2681 PRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQG----EGCSTTCAQNNVLPQTVQKRE 2736
+D+D LS S E A T+ +G + G T + P T
Sbjct: 3070 QQDADGLSDTSCE---------PPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFL 3120
Query: 2737 AKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVF 2796
+ + F + + AL+ + + + +Y+W+YLLSW P+FQPLASVF
Sbjct: 3121 GGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVF 3180
Query: 2797 NDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPR--MPAVNLGQVPPKHP 2854
+IA+LKDE P P+ + PPPLITAVA PG K+VPP+ A PP
Sbjct: 3181 TEIARLKDEARPCPPAPR-----IDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASH 3235
Query: 2855 RSPIPYHLGSLPE-GMTPNFSPSLSLLTMQPPALSP 2889
RSPI H GSL M+P+FSPSLS L + P +SP
Sbjct: 3236 RSPIS-HEGSLSSAAMSPSFSPSLSPLAARSPVVSP 3270
Score = 621 bits (1601), Expect = e-177
Identities = 623/2180 (28%), Positives = 940/2180 (43%), Gaps = 195/2180 (8%)
Query: 388 EDVPEDSPIGTVKAREPLNSSEPIFYRISSGD---LGGKFSIHPRLGTIRTRKPLDHETQ 444
E+ P + IG + A P ++ P+ Y IS+ + +G +I G +RT + LD E +
Sbjct: 53 EEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR 112
Query: 445 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
T P ++ EV + V D+ND+ PAF + +++ + T GT L A
Sbjct: 113 DRYRFTAVT-----PDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPA 167
Query: 505 EDRDSGRNGLIRYSIASPQPG-VFAIDRALG-------VLFLNGSLGAGEQRELTLTLRA 556
D D+GR G Y+++ G F ++ G L + G L + L L A
Sbjct: 168 RDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEA 227
Query: 557 EDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GP 614
D G P+ A +L V +++ +H+P+ F Y VSESL+P + +LQ A
Sbjct: 228 YDGGSPPRRAQALLDVTLLDINDHAPA--FNQSRYHAVVSESLAPGSPVLQVFASDADAG 285
Query: 615 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG--FLQ 672
A + S F I +TG + L R D+E + + V A DG +
Sbjct: 286 VNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA---RDGGAHPE 342
Query: 673 NVSTTVIVRVWDENDNSPTFLHDVLFLKVEESP------VPQGVIGKITAIDMDSGKNGQ 726
S V V V D NDN P+ V+FL + SP P ++ +I+ D D
Sbjct: 343 LGSAFVTVHVRDANDNQPSM--TVIFLSADGSPQVSEAAPPGQLVARISVSDPD------ 394
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
DG F +N + + +G A S D L C
Sbjct: 395 -------DGDFAHVNVS---------LEGGEGHFALSTQDSVI-----------YLVCVA 427
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
LDRE R + + V TD GSPP A A + VTD+NDN P F + L
Sbjct: 428 RR--------LDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRP 479
Query: 847 E-LHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTI 905
E L L G V V A+DPD+G N +VTYS++ + F ID +G I T
Sbjct: 480 EPLPEVALPGS----FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAAS 535
Query: 906 LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
L Y+ P ++ V+ATD G+PPL A V++ + ++ + + +PE +P
Sbjct: 536 LDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGT 595
Query: 966 IMSLIKSSDHLQQHYNGKLHFSI---VADDKDGHFEIDSSTGDLFLSKELDYET-TSHYL 1021
+ ++D + G L +S+ + F ID+ +GD+ ++ LD + S +
Sbjct: 596 CFLQVTATDADSGPF-GLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFD 654
Query: 1022 FRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD 1081
F V D L S V++ + + D+ND+ P F S+ P GT V A D
Sbjct: 655 FTVTAVDGG---GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHD 711
Query: 1082 -DDGSFLNSRIQYYIESHNPGTNP--FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQA 1138
D GS + R+ Y+I + G +P F + G L L R + V L + A D
Sbjct: 712 PDQGS--HGRLSYHILA---GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG 766
Query: 1139 VNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHITAHDPDEGRNG 1197
+ R I I+ P F V EDV G+ V + AH+P GR
Sbjct: 767 GLQAEPSAR---VDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP-PGRLA 822
Query: 1198 KVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTV 1257
VT S+ G+ F LD SGLL T PLD E+ + + G P + + V
Sbjct: 823 PVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRV 882
Query: 1258 TVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELF 1317
+ DVND +P F + N PG + + ALD DSGVNS++ F ++ G F
Sbjct: 883 LLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-GAF 941
Query: 1318 EINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDH--APEFI 1375
++ TG V L L + RDGG P +S + V+D AP F
Sbjct: 942 TVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFN 1001
Query: 1376 VSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRA 1435
+Y +++ VL A + + YH+ F + SG L A
Sbjct: 1002 SPTYRVDLPSGTTAGT--QVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAA 1059
Query: 1436 LDREQISNFTLVILC-----SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED 1490
LDRE + L ++ ++LG ++ + +V +L+ N+HSP +V E+
Sbjct: 1060 LDREAQELYILKVMAVSGSKAELGQQTGTATV--RVSILNQNEHSPRLSEDPTFLAVAEN 1117
Query: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFL--TDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548
GT V + A D+D G NG+ Y L E S AF I P +G + T TLDRE +S +
Sbjct: 1118 QPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSY 1177
Query: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQ------NPFDVFLSPESPTNQTT 1602
+D RSTT + V V D+NDN P Q + + P
Sbjct: 1178 QLLVQVQDGG-SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLV 1236
Query: 1603 VIVRADDLDLGPNGTVVFSFAETQS-MFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQ 1660
++A D D G NGT++++ S +FS+ ++GE+ P + L L DQ
Sbjct: 1237 TTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296
Query: 1661 GIPARTTTGLLVIHM------------EGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
G P R+ + L++ + E + + E G+ + +V A
Sbjct: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA 1356
Query: 1709 FAPDSIQDSMKYSIFSG-NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQ-LIVLAESSG 1766
P + ++ Y++ G + +G +L + SG+L + P LDFE + L V AE G
Sbjct: 1357 PEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARP--LDFEAGPPWRALTVRAEGPG 1413
Query: 1767 HRA--YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS-GLNGLIE 1823
+V V +QDEN+++P F + ++ E+ A + A+D D G N +
Sbjct: 1414 GAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVR 1473
Query: 1824 YSILSGNQE---EAFQIDALSGVITTKAILDYELTSSYSLIVQATDK---GMPRLSNTTV 1877
Y +L QE A ++DA +G ++ LD E T + L+V+ATD+ R +
Sbjct: 1474 YRLL--RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVS 1531
Query: 1878 IKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTK 1937
+V VTD NDNAP F V + ED PG HV D DL A S+ S
Sbjct: 1532 ARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH 1591
Query: 1938 FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLDVNDNPPVFSQ 1994
F + +TG + +V+ LD E+ E+ L + SD A L V V DVND P F Q
Sbjct: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
Query: 1995 DFYQVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKEFSIDPKNGTIFTISPVL 2052
Y V + E+ P G S+LTL AT D+ +N ++Y + SS+ FS+DP G + T+ L
Sbjct: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV-SSESFSLDPDTGVLTTLR-AL 1709
Query: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+ V A D G+P V + +ED N++AP F +L + E T
Sbjct: 1710 DREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQT 1768
Query: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
L D D N ++Y I+ G+ F ++ G + LDRE
Sbjct: 1769 LTMLRASDPD-VGANGQLQYRILDGDPSGAFVLDL----------ASGEFGTMRPLDREV 1817
Query: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
+ +L I A D G P LS+T ++++ VLD ND+ P F +Y V E P G+ + +
Sbjct: 1818 EPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQL 1877
Query: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AE 2291
A+D D G++ + Y + +G G F LE ++G L LD E+ +T +V A D A
Sbjct: 1878 QAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAA 1936
Query: 2292 KKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPISST----ICSINALDFDAGPY 2346
S V V ++V D NDHAP F S +P P ST + ++ A D DAG
Sbjct: 1937 AGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGAN 1996
Query: 2347 GELTYSIVS--PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG- 2403
+ Y + P T +D TG+I + L + A D G
Sbjct: 1997 ASILYRLAGTPPPGTT-----------VDSYTGEIRVARSPVALGPRDRVLFIVATDLGR 2045
Query: 2404 -DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
+A+ V+ V ++G E P F + T+ E I A A G +G I Y
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITY 2104
Query: 2463 SL--GTSSPFFSVNKTNGNI 2480
S+ G FS+ + G I
Sbjct: 2105 SILSGNEKGTFSIQPSTGAI 2124
Score = 615 bits (1587), Expect = e-175
Identities = 679/2533 (26%), Positives = 1066/2533 (42%), Gaps = 267/2533 (10%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+V ASDAD+G+ G + Y + + P F ID H G + + + +D E+ ++L+V
Sbjct: 276 QVFASDADAGVNGAVTYEINRRQSEGDGP--FSIDAHTGLLQLERPLDFEQ-RRVHELVV 332
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP----VFNPSTYVTSISDETQPG 193
+A+DG H L AFV V + D NDN P +F + +S+ PG
Sbjct: 333 QARDGG----AHPEL------GSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPG 382
Query: 194 TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVM 253
+ + +D D G + V NVS ++ G ++ +
Sbjct: 383 QLVARISVSDPDDGDFAHV-------NVS----LEGGEGHFALSTQ-------------- 417
Query: 254 NSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAA 313
+S+ + + R + ERD S +R + LH V D A + D +
Sbjct: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
Query: 314 ARYVANLAKILGEGIIYLTL---------------------------PLSHLESTTLS-- 344
+ G ++ +T P S + +T S
Sbjct: 478 RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLD 537
Query: 345 --------LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI 396
L+V A DGG +A V++ + +F+R Y +PE +
Sbjct: 538 YELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYN----ASLPEGTQP 593
Query: 397 GTVKAREPLNSSEPIFYRISSGDLGG--------KFSIHPRLGTIRTRKPLDHETQPVVV 448
GT + ++ + + S LG F I G + T + LD + P
Sbjct: 594 GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSF 653
Query: 449 LTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 508
+ S V + + D NDN P F IS +PPGTA+ RA D D
Sbjct: 654 DFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD 713
Query: 509 SGRNGLIRYSI-ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAED-QGVHPQAA 566
G +G + Y I A P +F +D G+L + L + L + AED G+ + +
Sbjct: 714 QGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS 773
Query: 567 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 626
V ++ P FE L Y V E ++P T + QAH P +P+ SL
Sbjct: 774 ARVDISIVPGTPTPP--IFEQLQYVFSVPEDVAPGTSVGIVQAH--NPPGRLAPVTLSLS 829
Query: 627 PSVDSAMFGIRPYTGWIYLRRQFDYE---STQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
+F + +G + R D E R + +P + V V +
Sbjct: 830 GGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVR----VLLD 885
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS-DGKFFKMNP 742
D NDNSP F + + + P I + A+D DSG N ++ + LL+ G F ++P
Sbjct: 886 DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDP 945
Query: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
TG + + + G A
Sbjct: 946 TTGHVRLMRPLGPSGGPA------------------------------------------ 963
Query: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
HE+ + D GSPPR + + V V D+ R P+ V + G V
Sbjct: 964 --HELELEARDGGSPPRTSHFRLRVVVQDVG-TRGLAPR-FNSPTYRVDLPSGTTAGTQV 1019
Query: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
V A+ PD G +TY +++E +S F ++ +G + L + + Y + V+A
Sbjct: 1020 LQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVS 1076
Query: 923 QGVPPL---QGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
L G A V + ++ ++ +S++ L + EN P + + ++D
Sbjct: 1077 GSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR-DSG 1135
Query: 980 YNGKLHFSIVADDKDGH-FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST 1038
NG+L +S+ +D F I TG++ + LD E S Y V D + S+T
Sbjct: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQD-GGSPPRSTT 1194
Query: 1039 VFLSIDVEDQNDHSPSFQDEL------IVISVEENVPIGTLVYVFNAKD-DDGSFLNSRI 1091
+ + V D ND+SP+F + I V + VP GTLV AKD D+G N I
Sbjct: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE--NGTI 1252
Query: 1092 QYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTA 1151
Y + PG+ F +HP G L+T + L R P +LT++A DQ L+ L
Sbjct: 1253 LYTLT--GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQ 1310
Query: 1152 QIVILDVNDHNPTFIS-FPNAHVKEDVTV--------GSLVHHITAHDPDEGRNGKVTYS 1202
+ + + P P A V +TV GSL+ + A P+ G +TY+
Sbjct: 1311 VLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYT 1368
Query: 1203 ILSG-NENMTFMLDESSGLLTTTCPLDYEM-KTQHILTVLALDDGTPALSSSQTLTVTVL 1260
++ G + TF LD +SG L PLD+E LTV A G A + + V V
Sbjct: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPG-GAGARLLRVQVQVQ 1427
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDS-GVNSKLQFEIM-PGASFELFE 1318
D N+ AP F + ++ EN PG + A D D G NS +++ ++
Sbjct: 1428 DENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALR 1487
Query: 1319 INSDTGEVVTTTILDREIQEVFTLRVLVRD---GGFPSLSSTTTILCTVEDENDHAPEFI 1375
+++ TG + LDRE L V D ++ + V DEND+AP F
Sbjct: 1488 LDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF- 1546
Query: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
S + + E+Q P V+A D D G V Y + G D F ++ +G LS R
Sbjct: 1547 ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVR 1605
Query: 1435 ALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVG 1494
LDREQ + L ++ SD G PPRS+ L V V D ND +P+F Y +RE+ G
Sbjct: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
Query: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
T +L L A D D G NGQ Y +S +F++DP +G L T LDRE + + + A
Sbjct: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
Query: 1555 RDCSIQGS--RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL 1612
+D +GS + T V ++V V D ND+ P + + PE QT ++RA D D+
Sbjct: 1724 QD---RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEV-PEGQDPQTLTMLRASDPDV 1779
Query: 1613 GPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTG 1669
G NG + + + F +D +GE + E P + L+++ D G PA + T
Sbjct: 1780 GANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATL 1839
Query: 1670 LLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNED 1728
LL + ++ D +F Y V E+ AGT ++ ++A PD+ +
Sbjct: 1840 LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTA 1899
Query: 1729 GVLSLCSKSGQLTVKEPKFLDFE----VRNEVQLIVLAESSGHRAYCKVAVLIQDENDNS 1784
G L SG+L + LD E V + A + V + ++D ND++
Sbjct: 1900 GAFLLEPSSGEL--RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHA 1957
Query: 1785 PCFEQSIYQASVSES----QLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDAL 1840
P F S + + + + A D D+G N I Y L+G +D+
Sbjct: 1958 PTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSY 2016
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-LPSEAVE 1899
+G I L + ATD G P S T VI V + + P F S
Sbjct: 2017 TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEAT 2076
Query: 1900 ITEDSLPGV-IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVL--VKTLDFE 1956
I E++ PG IV+ +VH N +S + GT F+I +TG + + + LDFE
Sbjct: 2077 IRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGT-FSIQPSTGAITVRSAEGLDFE 2135
Query: 1957 EMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
L++Q + L + + D NDN P F + Y +PES P+ +L + A
Sbjct: 2136 VSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEA 2195
Query: 2017 TDLE--SNENISYRILSSSKE---FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
DL+ S ISY + +S F +DP GTI T + +L + + T+ ++ A+D G+
Sbjct: 2196 DDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMATDRGS 2254
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVE 2131
P L + + + D N+ P + + L +SEDAL+GS + + D D +
Sbjct: 2255 PALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVD---SGPVLW 2310
Query: 2132 YSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS 2191
Y + Q+ F V + G + L LD E ++L +LA D P
Sbjct: 2311 YVLSPSGPQDPFSVG----------RYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHE 2357
Query: 2192 STAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
A +++ V DVNDN P FS Y + E TP GS I VSA DRD+G++ I Y++ S
Sbjct: 2358 GRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS 2417
Query: 2252 GNEKGHFYLEENTGVLYLI---KPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDD 2307
+ F ++ N G L+ I L ++ + ++A D + A V V + D
Sbjct: 2418 PAD--GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQ 2475
Query: 2308 NDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG-PYGELTYSIVSPCFLTHGMSYD 2366
NDHAP F S + V E+LP ST+ ++ A D D + + YSI+S G +
Sbjct: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG---NWGRVFQ 2532
Query: 2367 HDLFLIDP---------LTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEG 2417
+ L + G + + LD+E+ +Y LTV A D+G S VV V +
Sbjct: 2533 LEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTV 2592
Query: 2418 ID--EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP--FFSV 2473
+D + P+FT+ Y T+PE + VEASDAD G G++ +++ + P F +
Sbjct: 2593 LDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFEL 2652
Query: 2474 NKTNGNIYLIRAL 2486
++++G + L AL
Sbjct: 2653 DESSGTLRLAHAL 2665
Score = 606 bits (1562), Expect = e-172
Identities = 658/2490 (26%), Positives = 1041/2490 (41%), Gaps = 263/2490 (10%)
Query: 81 ASDADSGLYGFIEYSLY-DGFLSYEAPQAFRIDPHDG-------QICVSQDIDRERDPAT 132
A DAD+G G Y+L DG A + FR++ G ++ V+ ++DRE + +
Sbjct: 167 ARDADAGRLGTQGYALSGDG-----AGETFRLETRPGPDGTPVPELVVTGELDRE-NRSH 220
Query: 133 YDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQP 192
Y L +EA DG AQA + V L D+ND+ P FN S Y +S+ P
Sbjct: 221 YMLQLEAYDGGSPPRR----------AQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270
Query: 193 GTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGLYSPEVE----------- 239
G+ ++ V A+D D+G+ G V YE+ F+ID+ TGL E
Sbjct: 271 GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330
Query: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYL 299
++ A + A E+ ++ + H + ++ + F ++ G + +
Sbjct: 331 VVQARDGGAHPELGSAF-----VTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLV 385
Query: 300 KVQDEAASADGEAAARYVA------NLAKILGEGIIYLTLPLSHL---ESTTLSLMVSAQ 350
+ DG+ A V+ + A + +IYL L E +L V+A
Sbjct: 386 ARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
Query: 351 DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAREP-L 405
D G A +H+ F+R Y E +PE + G+ V AR+P
Sbjct: 446 DSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYR---PEPLPEVALPGSFVVRVTARDPDQ 502
Query: 406 NSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS-APACSST 464
++ + Y ++ G FSI P G I T LD+E +P L V A G P SS
Sbjct: 503 GTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSA 562
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS----IA 520
V++ + DVNDN P F RT + + T PGT A D DSG GL+ YS +
Sbjct: 563 TVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLG 622
Query: 521 SPQPGVFAIDRALGVLFLNGSLGAGE-QRELTLTLRAEDQGVHPQAALLVLTVVIEKREH 579
S F ID G + +L + T+ A D G ++ + V + ++ ++
Sbjct: 623 SSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG-GLKSMVYVKVFLSDENDN 681
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
P F Y +S P T +L+ +AH Q + L Y + +F +
Sbjct: 682 PPQ--FYPREYAASISAQSPPGTAVLRLRAHD-PDQGSHGRLSYHILAGNSPPLFTLDEQ 738
Query: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPED--GFLQNVSTTVIVRVWDENDNSPTFLHDVL 697
+G + + + + A ED G S V + + P F
Sbjct: 739 SGLLTVAWPLARRANSVVQLEIGA---EDGGGLQAEPSARVDISIVPGTPTPPIFEQLQY 795
Query: 698 FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWAD 757
V E P +G + A P G + +T
Sbjct: 796 VFSVPEDVAPGTSVGIVQA---------------------------HNPPGRLAPVT--- 825
Query: 758 GAAAFSGTD--FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRG 815
+ SG D FS D + G L LDRE G + G
Sbjct: 826 --LSLSGGDPRGLFSLDAV-------------SGLLQTLRPLDRELLGPVLELEVRAGSG 870
Query: 816 SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875
PP A V V + D+NDN P FP L G P + T+ A DPD G N
Sbjct: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTP----IYTLRALDPDSGVN 926
Query: 876 AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVN 935
+ VT+++ + F +D G +R L P++ + + A D G PP +
Sbjct: 927 SRVTFTLLA-GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLR 985
Query: 936 IQVIPL-SKGRA--IMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD 992
+ V + ++G A S R + T+++ + Q G + + + A+
Sbjct: 986 VVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQV-----QAQAPDGGPITYHLAAEG 1040
Query: 993 KDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL--SLSSTVFLSIDVEDQND 1050
F ++ +G L++ LD E Y+ +V+ SK + T + + + +QN+
Sbjct: 1041 ASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
Query: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
HSP ++ ++V EN P GT V A D D S N R+ Y ++ + + F IHP
Sbjct: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGRLTYSLQQLSEDSKAFRIHPQ 1159
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN 1170
G + T+ LDRE + L V D + R + T + +LD+ND++PTF+
Sbjct: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGG---SPPRSTTGTVHVAVLDLNDNSPTFLQASG 1216
Query: 1171 A-------HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTT 1223
A V + V G+LV + A DPDEG NG + Y+ L+G + F L SG L T
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT-LTGPGSELFSLHPHSGELLT 1275
Query: 1224 TCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL-------------DVNDEAPVFK 1270
PL + ++LT+ A D G+P S+S L V VL + + APV
Sbjct: 1276 AAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPV-- 1333
Query: 1271 QHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE-LFEINSDTGEVVTT 1329
+ + E PG + V A +GV + L + ++ GA E F +++ +G +
Sbjct: 1334 PVVLTVTAAEGLRPGSLLGSV-AAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLA 1391
Query: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP 1389
LD E + + +G + + + V+DEN+HAP F + + EN EP
Sbjct: 1392 RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEP 1451
Query: 1390 -EVVYTVLASDMDA-GNNRAVEYHIIDGNTD-ECFTINEMSGELSTTRALDREQISNFTL 1446
+YT ASD D G N V Y ++ ++ +G LS R LDRE L
Sbjct: 1452 GAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLL 1511
Query: 1447 VILCSDL---GDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR--EDAEVGTVVLVLS 1501
++ +D R++ + +V V D ND++P F + S VR ED G L +
Sbjct: 1512 LVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS---PSRVRLPEDQPPGPAALHVV 1568
Query: 1502 AVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
A D D G + Y L G F + +G L LDRE R++H + VA D G
Sbjct: 1569 ARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASD---HG 1625
Query: 1562 S--RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVV 1619
S RS T ++ V V DVND P +Q + V L +P + + +RA D D+G NG V
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVT 1685
Query: 1620 FSFAETQSMFSIDKYTGEI-QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE 1678
+ ++S FS+D TG + + E I L + D+G P + T + + +E E
Sbjct: 1686 YGGVSSES-FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
Query: 1679 DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKS 1737
+ + L + ++ ++A PD ++Y I G+ G L S
Sbjct: 1745 NDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLAS 1804
Query: 1738 GQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSIYQA 1794
G+ P LD EV QL + A G A + V + D ND++P F Y
Sbjct: 1805 GEFGTMRP--LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV 1862
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
V E ++Q+ A D D+G NG + Y + +G AF ++ SG + T A LD E
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQ 1921
Query: 1855 TSSYSLIVQATD-KGMPRLSNTTVIKVQVTDINDNAPAF--------LPSEAVEITEDSL 1905
SY+ V A D LS T + + V D+ND+AP F LP + +L
Sbjct: 1922 CPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTL 1981
Query: 1906 PGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKT---LDFEEMTEYE 1962
+ D N++ ++ A PGT +D TG + + ++ L + +
Sbjct: 1982 -ALATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDRVLFI 2038
Query: 1963 LLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDL-ES 2021
+ + G ++V + + P F + + T+ E+ P G +++ A +
Sbjct: 2039 VATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGT 2098
Query: 2022 NENISYRILSSSKE--FSIDPKNGTI---------FTISPVLLLDTISTTQFLVEASDGG 2070
N I+Y ILS +++ FSI P G I F +SP L L +++A GG
Sbjct: 2099 NGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRL--------VLQAESGG 2150
Query: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
A T++ + ++D N+ AP F Y L E + L+ D D +
Sbjct: 2151 ---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD-QGSGGQI 2206
Query: 2131 EYSIISGN-SQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPP 2189
YS+ + ++ FHV+ G + LDRE A LV++A+D G P
Sbjct: 2207 SYSLAASQPARGLFHVD----------PTTGTITTTAILDREIWAETRLVLMATDRGSPA 2256
Query: 2190 LSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNI 2249
L +A +++ V+D NDN P + V E LGS I V+ ND D+G +++ +
Sbjct: 2257 LVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG---PVLWYV 2312
Query: 2250 IS-GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDN 2308
+S + F + G + L PLD+E+ ++ L + A D H A + V V D N
Sbjct: 2313 LSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANLTVLVEDVN 2370
Query: 2309 DHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHD 2368
D+AP F S + ++ E+ P S I S++A D D+G G ++Y + SP D
Sbjct: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA----------D 2420
Query: 2369 LFLIDPLTG---DIHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEP 2423
F +DP G I L ++ + ++A+D G A V V ++ ++ P
Sbjct: 2421 GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAP 2480
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
FT Y + E + +EA+DAD
Sbjct: 2481 SFTLSHYRVAVTEDLPPGSTLLTLEATDAD 2510
Score = 573 bits (1476), Expect = e-162
Identities = 664/2577 (25%), Positives = 1100/2577 (42%), Gaps = 275/2577 (10%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI---CVSQDIDRERDPATYDL 135
++ SD D G + + SL G F + D I CV++ +DRE A Y+L
Sbjct: 388 ISVSDPDDGDFAHVNVSLEGG------EGHFALSTQDSVIYLVCVARRLDREERDA-YNL 440
Query: 136 LVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTS-ISDETQPGT 194
V A D L A+A + + DVNDN P F+ Y + + PG+
Sbjct: 441 RVTATDSGSPP----------LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
Query: 195 EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKE--- 251
++ V A D D G G V Y L PG + F+ID T+G+ + +++++ + +
Sbjct: 491 FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGI----ITTAASLDYELEPQPQL 546
Query: 252 VMNSLEMFLPLLRHFKKVE---RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASA 308
++ + + LP L V +D E +F+ + +G + +Q A A
Sbjct: 547 IVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQP-GTCFLQVTATDA 605
Query: 309 DGEAAARYVANLAKILG------------EGIIYLTLPLSHLES-TTLSLMVSAQDGGGL 355
D +L LG G + T L + ++ V+A DGGGL
Sbjct: 606 DSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGL 665
Query: 356 TAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE-PIFYR 414
+++ V + + P +F +Y + P + + ++A +P S + Y
Sbjct: 666 KSMVY--VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723
Query: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVMDV 473
I +G+ F++ + G + PL VV L + A+ G A S V+I+++
Sbjct: 724 ILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPG 783
Query: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 532
P F + + + PGT++ + +A + GR + S++ P G+F++D
Sbjct: 784 TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAV 842
Query: 533 LGVLFLNGSLGAGEQRE-----LTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFE 586
G+L L RE L L +RA GV P A+ + V+++ ++SP+ F
Sbjct: 843 SGLLQTLRPL----DRELLGPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPA--FP 895
Query: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA-SPLRYSLEPSVDSAMFGIRPYTGWIYL 645
V + + +P T + +A L P S + ++L A F + P TG + L
Sbjct: 896 APEDTVLLPPNTAPGTPIYTLRA--LDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRL 952
Query: 646 RRQFDYESTQTYNFRVFAWIPEDG---------FLQNVSTTVIVRVWDENDNSPTFLHDV 696
R + + A DG L+ V V R NSPT+ D
Sbjct: 953 MRPLGPSGGPAHELELEA---RDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVD- 1008
Query: 697 LFLKVEESPVPQGVIG--KITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGPAGTIYV 752
+P G ++ + + G + Y L ++G F + P +G
Sbjct: 1009 ---------LPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG------- 1052
Query: 753 ITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVT 812
W A A + + ++LK + + EL
Sbjct: 1053 --WLWVRA-------ALDREAQELYILKVMAVSGSKAEL--------------------- 1082
Query: 813 DRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 872
+ T V VS+ + N++ P L + V E QP V VFA D D
Sbjct: 1083 ----GQQTGTATVRVSILNQNEHSP----RLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134
Query: 873 GNNAEVTYSVS--SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQG 930
G N +TYS+ SEDS F+I GE+ T L + + SY++ V D G PP
Sbjct: 1135 GPNGRLTYSLQQLSEDSK-AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
Query: 931 QAVVNIQVIPLSKGRAIMSQ------NIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL 984
V++ V+ L+ Q + +P+ + P +++ +++ D + NG +
Sbjct: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDP-DEGENGTI 1252
Query: 985 HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTD-----HSKNLSLSSTV 1039
+++ + F + +G+L + L HY+ + D S +L L V
Sbjct: 1253 LYTLTGPGSE-LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQV 1311
Query: 1040 FLSI-------DVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
S D+ +++ +P ++ ++ E + G+L+ A + G +
Sbjct: 1312 LPSARLAEPPPDLAERDPAAP--VPVVLTVTAAEGLRPGSLLGSVAAPEPAGV---GALT 1366
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRES-IPTVILTVTASDQAVNVTDRRLRSLTA 1151
Y + F + + G L LD E+ P LTV A R L
Sbjct: 1367 YTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPG----GAGARLLRV 1422
Query: 1152 QIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHITAHDPD-EGRNGKVTYSILSGNEN 1209
Q+ + D N+H P F P A + E+ G+ ++ A D D G N V Y +L
Sbjct: 1423 QVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPP 1482
Query: 1210 M-TFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQ-----TLTVTVLDVN 1263
+ LD +G L+ LD E +L V A D PA +S + + V V D N
Sbjct: 1483 VPALRLDARTGALSAPRGLDRETTPALLLLVEATD--RPANASRRRAARVSARVFVTDEN 1540
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDT 1323
D APVF + E+Q PG V A D D G +++ + + G F ++S T
Sbjct: 1541 DNAPVFASP-SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSST 1598
Query: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
G + LDRE + L V+ D G P S+T + +V D ND AP F Y + +
Sbjct: 1599 GALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLL 1658
Query: 1384 LENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQIS 1442
EN P + T+ A+D D G N V Y G + E F+++ +G L+T RALDRE+
Sbjct: 1659 RENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQE 1715
Query: 1443 NFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSA 1502
L + D G PP+ + + ++V V D NDH+P+F + + V E + T+ + L A
Sbjct: 1716 EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRA 1774
Query: 1503 VDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
D D G NGQ +Y + D + SGAF +D SG T LDRE ARD Q
Sbjct: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGG-QP 1833
Query: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFS 1621
+ S T+++ V V D ND+ P + V + + P + ++A D D G NG V +
Sbjct: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYY 1893
Query: 1622 F-AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGI--PARTTTGLLVIHMEG 1677
A T F ++ +GE++ E P + + D P TT + + +
Sbjct: 1894 LGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
Query: 1678 EDVKISF-SHHLYKGLVTENCEAGT---SIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSL 1733
D +F + L L T ++ T++A D+ ++ +G ++
Sbjct: 1954 NDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
Query: 1734 CSKSGQLTV-KEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLI---QDENDNSPCFEQ 1789
S +G++ V + P L R+ V L ++A G A V+I Q E + P F +
Sbjct: 2014 DSYTGEIRVARSPVALG--PRDRV-LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070
Query: 1790 SIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAI 1849
+ +A++ E+ ++ A G NG I YSILSGN++ F I +G IT ++
Sbjct: 2071 ASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSA 2129
Query: 1850 --LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
LD+E++ L++QA G TV+ + + D NDNAP FL V +S P
Sbjct: 2130 EGLDFEVSPRLRLVLQAESGGAFAF---TVLTLTLQDANDNAPRFLRPHYVAFLPESRPL 2186
Query: 1907 -GVIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYEL 1963
G ++ V D+D S S++ ++ + F +D TG + LD E E L
Sbjct: 2187 EGPLL-QVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRL 2245
Query: 1964 LIQISD---SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
++ +D L V V+D NDN P Q +++ V E +G + ++ D++
Sbjct: 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVD 2304
Query: 2021 SNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078
S + Y + S + FS+ G + P L + Q + A DG + LT
Sbjct: 2305 SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGP-LDFEQCDRYQLQLLAHDGPHEGRANLT 2363
Query: 2079 LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGN 2138
++ +ED+N+ AP F+ Y + L E GS +++ S D D + N ++ Y + S
Sbjct: 2364 VL---VEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD-SGANGHISYHLAS-- 2417
Query: 2139 SQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISI 2198
+ F V+ ++ + VG + L H + S + ++V+ A D G P ++ A + +
Sbjct: 2418 PADGFSVDP---NNGTLFTIVGTVALGH----DGSGAVDVVLEARDHGAPGRAARATVHV 2470
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD-TGSHAEIIYNIISGNEKGH 2257
Q+ D ND+ P+F+ Y V E P GS + + A D D + SHA + Y+IISGN
Sbjct: 2471 QLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV 2530
Query: 2258 FYLEEN--------------TGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFV 2302
F LE G L L++PLD+E +T++ LTV A+D + S V V
Sbjct: 2531 FQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTV 2590
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHG 2362
+VLD ND+ P F +S+ VPE+ P+ + + + A D D GP+G + +++ S
Sbjct: 2591 TVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS------- 2643
Query: 2363 MSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLV-VWVDIEGIDEF 2421
LF +D +G + LD E ++ L VQA D A +L V ++++ +++
Sbjct: 2644 -GDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDH 2702
Query: 2422 EPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP------FFSVNK 2475
P F + ++ E L+ + A D DAG G + YSL + P F++N
Sbjct: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
Query: 2476 TNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPL 2532
+ G +RA + + E T +++ + + + AS TV V V+ E P+
Sbjct: 2763 STGE---LRA----RVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPV 2812
Score = 570 bits (1469), Expect = e-162
Identities = 535/1871 (28%), Positives = 831/1871 (44%), Gaps = 171/1871 (9%)
Query: 746 PAGT----IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREH 801
PAGT +Y I+ +G+ GTD A DE V + LDRE
Sbjct: 69 PAGTAAPLMYFISAQEGSGV--GTDLAI--DEHSGVVRTAR-------------VLDREQ 111
Query: 802 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 861
R + T + D AT+ V V V DIND+ P FPQ ++V E
Sbjct: 112 RDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAA----LQVPEHTAFGTR 161
Query: 862 VTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG-------EIRTTTILSYDYRPSY 914
A+D D G Y++S + + + F+++ G E+ T L + R Y
Sbjct: 162 YPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
Query: 915 RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974
+ + A D G PP + QA++++ ++ ++ +Q+ H ++ E+L P + + +SD
Sbjct: 222 MLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASD 281
Query: 975 HLQQHYNGKLHFSIVA--DDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
NG + + I + DG F ID+ TG L L + LD+E + V D +
Sbjct: 282 -ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAH 340
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVIS------VEENVPIGTLVYVFNAKD-DDGS 1085
L S F+++ V D ND+ PS +I +S V E P G LV + D DDG
Sbjct: 341 PELGSA-FVTVHVRDANDNQPSMT--VIFLSADGSPQVSEAAPPGQLVARISVSDPDDGD 397
Query: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVS---RLDRESIPTVILTVTASDQAVNVT 1142
F + + S G F + + V RLDRE L VTA+D
Sbjct: 398 FAHVNV-----SLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG---- 448
Query: 1143 DRRLRSLTAQIV-ILDVNDHNPTFIS--FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKV 1199
LR+ A ++ + DVND+ P F + + E GS V +TA DPD+G NG+V
Sbjct: 449 SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV 508
Query: 1200 TYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTV 1259
TYS+ G F +D +SG++TT LDYE++ Q L V+A D G P L+SS T++V +
Sbjct: 509 TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVAL 568
Query: 1260 LDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPG---ASFEL 1316
DVND P F++ Y AS+ E PG +V A D DSG L + + G +
Sbjct: 569 QDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
Query: 1317 FEINSDTGEVVTTTILDREI-QEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
F I++ +G+V TT LDR+ F V DGG L S + + DEND+ P+F
Sbjct: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFY 686
Query: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
Y + P V + A D D G++ + YHI+ GN+ FT++E SG L+
Sbjct: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAW 746
Query: 1435 ALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVG 1494
L R S L I D G + + ++ P F L Y SV ED G
Sbjct: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
Query: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
T V ++ A + L T + G F++D +SG L+T LDRE
Sbjct: 807 TSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEV 865
Query: 1555 RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGP 1614
R S ++V + DVNDN P V L P + +RA D D G
Sbjct: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGV 925
Query: 1615 NGTVVFS-FAETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTT---TG 1669
N V F+ A F++D TG ++ + P L+L+ D G P RT+
Sbjct: 926 NSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLR 985
Query: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
++V + + F+ Y+ + AGT ++ V+A APD + Y + +
Sbjct: 986 VVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDG--GPITYHLAAEGASS 1043
Query: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRA-------YCKVAVLIQDEND 1782
L +SG L V+ LD E + E+ ++ + SG +A V V I ++N+
Sbjct: 1044 PFGLEPQSGWLWVRAA--LDREAQ-ELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
Query: 1783 NSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE-EAFQIDALS 1841
+SP + +V+E+Q V +VFATD DSG NG + YS+ +++ +AF+I +
Sbjct: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQT 1160
Query: 1842 GVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA---- 1897
G +TT LD E SSY L+VQ D G P S T + V V D+NDN+P FL +
Sbjct: 1161 GEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGG 1220
Query: 1898 ---VEITEDSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTK-FAIDQNTGVVVLVK 1951
+++ + PG +VT + D D N +++ + PG++ F++ ++G ++
Sbjct: 1221 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL---TGPGSELFSLHPHSGELLTAA 1277
Query: 1952 TLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLD---VNDNPPVFSQD--------FY 1997
L E Y L + D A L+V+VL + + PP ++
Sbjct: 1278 PLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL 1337
Query: 1998 QVTVPESIPVGYSVLTLSATDLESNENISYRILSSSK---EFSIDPKNGTIFTISPVLLL 2054
VT E + G + +++A + ++Y ++ + F++D +G ++ P+
Sbjct: 1338 TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
Query: 2055 DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLV 2114
V A G R L V++ ++D N +AP F L+L E+ G+ L
Sbjct: 1398 AGPPWRALTVRAEGPGGAGARLLR-VQVQVQDENEHAPAFARDPLALALPENPEPGAALY 1456
Query: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY------KQVGYLVLLHSL 2168
TF D D N+ V Y ++ E P + G L L
Sbjct: 1457 TFRASDADGPGPNSDVRYRLL---------------RQEPPVPALRLDARTGALSAPRGL 1501
Query: 2169 DREASASHELVILASD---SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
DRE + + L++ A+D + ++ + V D NDN P F+S S + E P
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPP 1560
Query: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
G V A D D G A + Y + SG + GHF L +TG L +++PLD E+ + LTV
Sbjct: 1561 GPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTV 1619
Query: 2286 QASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG 2344
ASD + V+ VSV D ND AP F +S ++ EN P +++ ++ A D D G
Sbjct: 1620 VASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVG 1679
Query: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD 2404
G++TY VS + F +DP TG + + LD E + LTV A+D+G
Sbjct: 1680 ANGQVTYGGVS-----------SESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728
Query: 2405 --ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
+ V V +E ++ P F +PE +D Q + + ASD D G +G + Y
Sbjct: 1729 PPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQTLTMLRASDPDVGANGQLQY 1787
Query: 2463 SL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVF 2520
+ G S F ++ +G +R L E +++I A + A+ +
Sbjct: 1788 RILDGDPSGAFVLDLASGEFGTMRPL-----DREVEPAFQLRIEARDGGQPALSATLLLT 1842
Query: 2521 VNVSFSSEGTP 2531
V V +++ P
Sbjct: 1843 VTVLDANDHAP 1853
Score = 566 bits (1459), Expect = e-160
Identities = 592/2191 (27%), Positives = 945/2191 (43%), Gaps = 213/2191 (9%)
Query: 390 VPEDSPIGTVKAREPLNSSEP-----IFYRISSGDLGGKFSIHPRLGTIRTRKP------ 438
VPE + GT EP ++ Y +S G F + R G T P
Sbjct: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211
Query: 439 -LDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG 496
LD E + +L ++A GS P + +++T++D+ND+ PAF ++ +S++ PG
Sbjct: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271
Query: 497 TALYLARAEDRDSGRNGLIRYSI---ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 553
+ + A D D+G NG + Y I S G F+ID G+L L L ++R L
Sbjct: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
Query: 554 LRAEDQGVHPQAALLVLTV-VIEKREHSPSWT--FEHLVYQVEVSESLSPMTQMLQTQAH 610
++A D G HP+ +TV V + ++ PS T F +VSE+ +P Q++ +
Sbjct: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEA-APPGQLVARISV 390
Query: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL---RRQFDYESTQTYNFRVFAWIPE 667
+ + SLE F + IYL R+ D E YN RV A
Sbjct: 391 SDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG 448
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESP---VPQGVIGKITAIDMDSGKN 724
L+ ++ V D NDN+P F D + E P +P + ++TA D D G N
Sbjct: 449 SPPLR-AEAAFVLHVTDVNDNAPAF--DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTN 505
Query: 725 GQLLYFLL--SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782
GQ+ Y L + +F ++P +G +IT A
Sbjct: 506 GQVTYSLAPGAHTHWFSIDPTSG------IITTA-------------------------- 533
Query: 783 FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 842
+LD E ++ V+ TD G PP ++ V V++ D+NDN P F +
Sbjct: 534 ------------ASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
Query: 843 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDHFKIDANNGE 899
+ + EG V A D D G ++YS+ + S F+IDA++G+
Sbjct: 582 F----YNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
Query: 900 IRTTTILSYDYRP-SYRMSVIATDQGVPPLQGQAVVNI----------QVIPLSKGRAIM 948
+ TT L D P S+ +V A D G L+ V + Q P +I
Sbjct: 638 VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASIS 695
Query: 949 SQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL 1008
+Q+ P + +++ D Q +G+L + I+A + F +D +G L +
Sbjct: 696 AQS----------PPGTAVLRLRAHDP-DQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV 744
Query: 1009 SKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENV 1068
+ L S + D L + + I + P F+ V SV E+V
Sbjct: 745 AWPLARRANSVVQLEIGAED-GGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDV 803
Query: 1069 PIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTV 1128
GT V + A + G + + + +P F + G L T+ LDRE + V
Sbjct: 804 APGTSVGIVQAHNPPGRL--APVTLSLSGGDP-RGLFSLDAVSGLLQTLRPLDRELLGPV 860
Query: 1129 ILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTV-GSLVHHIT 1187
+ + V R ++++ DVND++P F + + + T G+ ++ +
Sbjct: 861 LELEVRAGSGVPPAFAVAR---VRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
Query: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247
A DPD G N +VT+++L+G F +D ++G + PL H L + A D G+P
Sbjct: 918 ALDPDSGVNSRVTFTLLAGGGG-AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976
Query: 1248 ALSSSQTLTVTVLDVNDE--APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305
+S L V V DV AP F Y + G V +V+A D G +
Sbjct: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PIT 1033
Query: 1306 FEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSL---SSTTTILC 1362
+ + + F + +G + LDRE QE++ L+V+ G L + T T+
Sbjct: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRV 1093
Query: 1363 TVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTD-EC 1420
++ ++N+H+P + V ENQ P V V A+D D+G N + Y + + D +
Sbjct: 1094 SILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKA 1153
Query: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
F I+ +GE++T + LDREQ S++ L++ D G PPRS+ + V VLD ND+SP+F
Sbjct: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
Query: 1481 LYYQS------SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTL 1534
+ V + GT+V L A D DEG NG Y LT S F++ P SG L
Sbjct: 1214 ASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
Query: 1535 KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSP 1594
T+ L R R + + A D QGS + +++ V V + + E P P
Sbjct: 1274 LTAAPLIRAERPHYVLTLSAHD---QGSPPRSASLQLLV-QVLPSARLAEPPPDLAERDP 1329
Query: 1595 ESPTNQTTVIVRADDLDLG----------PNGTVVFSF-----AETQSMFSIDKYTGEIQ 1639
+P + A+ L G P G ++ A+ + F++D +G +
Sbjct: 1330 AAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLY 1389
Query: 1640 FQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVK---ISFSHHLYKGLVTEN 1696
+ E P W L V +G P LL + ++ +D +F+ + EN
Sbjct: 1390 LARPLDFEAGPPWRALTVRAEG-PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPEN 1448
Query: 1697 CEAGTSIVTVKAFAPD--SIQDSMKYSIFSGNED-GVLSLCSKSGQLTVKEPKFLDFEVR 1753
E G ++ T +A D ++Y + L L +++G L+ P+ LD E
Sbjct: 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSA--PRGLDRETT 1506
Query: 1754 NEVQLIVLA------ESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVI 1807
+ L+V A S A V + DENDN+P F S + + E Q +
Sbjct: 1507 PALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAAL 1565
Query: 1808 QVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDK 1867
V A D D G + Y + SG + F++ + +G ++ LD E + + L V A+D
Sbjct: 1566 HVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
Query: 1868 GMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIF 1926
G P S T V+ V V D+ND AP F E +V + E++ PG + + D D+ +
Sbjct: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQV 1684
Query: 1927 SFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVL 1983
++ S+ F++D +TGV+ ++ LD EE E L + D T + V V
Sbjct: 1685 TYGGVSS--ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742
Query: 1984 DVNDNPPVFSQDFYQVTVPE-SIPVGYSVLTLSATDLESNENISYRILSS--SKEFSIDP 2040
D ND+ P F + VPE P ++L S D+ +N + YRIL S F +D
Sbjct: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
Query: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
+G T+ P L + Q +EA DGG P L A L+ + + D N++AP F V +Y+
Sbjct: 1803 ASGEFGTMRP-LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYS 1861
Query: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
+ + ED G+ L+ D D N +V Y + +G + F +E G
Sbjct: 1862 VEVPEDVPAGTLLLQLQAHDPD-AGANGHVTYYLGAGTA-GAFLLE----------PSSG 1909
Query: 2161 YLVLLHSLDREASASHELVILASD-SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHV 2219
L +LDRE S+ + A D + PLS+T ++I V DVND+ P F + +
Sbjct: 1910 ELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
Query: 2220 KESTPLGSHITV----VSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK-PLD 2274
P S T+ + A DRD G++A I+Y ++G ++ TG + + + P+
Sbjct: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVA 2028
Query: 2275 YEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTIC 2334
+ V + V+ V + + + P+F +S + EN P + I
Sbjct: 2029 LGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
Query: 2335 SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI--LDYENGNK 2392
S A+ G G +TYSI+S + F I P TG I + LD+E +
Sbjct: 2089 SPRAV-HAGGTNGPITYSILS--------GNEKGTFSIQPSTGAITVRSAEGLDFEVSPR 2139
Query: 2393 YCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDA 2452
L +QA + G A A V+ + ++ ++ P F + Y LPE + +VEA D
Sbjct: 2140 LRLVLQA-ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDL 2198
Query: 2453 DAGIDGVILYSLGTSSP---FFSVNKTNGNI 2480
D G G I YSL S P F V+ T G I
Sbjct: 2199 DQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 1044 bits (2699), Expect = 0.0
Identities = 573/807 (71%), Positives = 601/807 (74%), Gaps = 94/807 (11%)
Query: 104 EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFV 163
E +F ID G I + +DRE A +L V A+D L + LSA V
Sbjct: 601 ECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQD----------LGEPPLSATCLV 649
Query: 164 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS- 222
+ ++DVNDN P+F Y +I++ G + V A+D DSG+YG + Y L G +S
Sbjct: 650 SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
Query: 223 ---SLFTIDSTTG---------------LYSPEVEILSAVNFSADKEVMNSLEMFL---P 261
F ID G Y VE SA V LE P
Sbjct: 710 EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
Query: 262 LLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLA 321
+ V + + G ++ L ++ A N++
Sbjct: 770 VFNPSTYVTSISDETQP-------------GTEIINVLATDQDSGIYGTVAYELIPGNVS 816
Query: 322 KILG----EGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 377
+ GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 378 ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 437
ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK
Sbjct: 877 ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 936
Query: 438 PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497
PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT
Sbjct: 937 PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
Query: 498 ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE 557
ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE
Sbjct: 997 ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE 1056
Query: 558 DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 617
DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA
Sbjct: 1057 DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 1116
Query: 618 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 677
ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT
Sbjct: 1117 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 1176
Query: 678 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 737
VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF
Sbjct: 1177 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 1236
Query: 738 FKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVAL 797
FKMNPNT GELINWVAL
Sbjct: 1237 FKMNPNT--------------------------------------------GELINWVAL 1252
Query: 798 DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 857
DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP
Sbjct: 1253 DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 1312
Query: 858 VNMLVTTVFAKDPDEGNNAEVTYSVSS 884
VNMLVTTVFAKDPDEGNNAEVTYSVSS
Sbjct: 1313 VNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 330 bits (845), Expect = 2e-89
Identities = 358/1307 (27%), Positives = 544/1307 (41%), Gaps = 151/1307 (11%)
Query: 1060 IVISVEENVPIGTLVYVFNA-------KDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
+ +SV+E +P TLV A ++ G FL+ +P + F +HP G
Sbjct: 69 LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED-----SDDSPLLDDFHVHPDTG 123
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF-ISFPNA 1171
+ T RLDRE AV + +I + DVNDH+P F +
Sbjct: 124 IIRTARRLDRERRDHYSFVAATLLGAV---------VQVEIRVNDVNDHSPRFPLDSLQL 174
Query: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNE--------------------NMT 1211
V E G+ AHDPD G Y+++ ++
Sbjct: 175 DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
Query: 1212 FMLDESSGL----LTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAP 1267
+ SS L L LD E H L + A D G P + ++ + VLD ND P
Sbjct: 235 LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP 294
Query: 1268 VFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI----MPGA--------SFE 1315
VF+Q Y A+V+E+ PG V RV A DRD G N +++ + +PGA
Sbjct: 295 VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
Query: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPE-- 1373
F + +G V LDRE Q L V RDGG +T + V D ND+ P
Sbjct: 355 YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
Query: 1374 --FIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEY--HIIDGNTDECFTINEMSG 1428
F+ V E P + V V SD D + E + G D +++ G
Sbjct: 415 VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
Query: 1429 E---------------LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDAND 1473
E L LDRE + L+++ +D G PP S+ L +RV D ND
Sbjct: 475 EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
Query: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNG--------------------QT 1513
P F +Y++SV E A GTVV+ +SA D DE + Q+
Sbjct: 535 QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
Query: 1514 EYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
+ T E +F ID SG + T TLDRE + VA+D + S T ++ + V
Sbjct: 595 KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG-EPPLSATCLVSITV 653
Query: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF------AETQS 1627
DVNDN+P+ + ++ ++ +P + V A D D G G + +S E
Sbjct: 654 DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
Query: 1628 MFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSH 1686
F ID + G+I Q+ E P L V + + + + +E D F+
Sbjct: 714 AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNP 773
Query: 1687 HLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEP 1745
Y +++ + GT I+ V A DS I ++ Y + GN + ++ S +G + + P
Sbjct: 774 STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
Query: 1746 KFLDFEVRNEVQLIVLAESSGHRA---YCKVAVLIQDENDNSPCFEQSIYQASVSESQLY 1802
L + L+V A+ G V + I FE+ Y V E
Sbjct: 834 --LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
Query: 1803 NAHVIQVFATD-LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861
++ + V A + L+S + I Y I SG+ F I G I T+ LD+E L
Sbjct: 892 DSPIGTVKAREPLNS--SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
Query: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDL 1920
VQA P S+T V + V D+NDN PAFL S+ + I++ + PG + D D
Sbjct: 950 VQAQLGSAPACSSTEV-NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 1008
Query: 1921 NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVV 1980
+ ++ S FAID+ GV+ L +L E E L ++ D + + AL+V
Sbjct: 1009 GRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLV 1068
Query: 1981 R--VLDVNDNPP--VFSQDFYQVTVPESIPVGYSVLTLSATDL---ESNENISYRILSS- 2032
V++ ++ P F YQV V ES+ +L A L + + Y + S
Sbjct: 1069 LTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSV 1128
Query: 2033 -SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEA---SDGGNPDLRALTLVEIGIEDMN 2088
S F I P G I+ + ++ T F V A DG ++ T V + + D N
Sbjct: 1129 DSAMFGIRPYTGWIY-LRRQFDYESTQTYNFRVFAWIPEDGFLQNVS--TTVIVRVWDEN 1185
Query: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETK 2148
+ +P F L + E + + + ID D + +N + Y ++S + K
Sbjct: 1186 DNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD-SGKNGQLLYFLLS---------DGK 1235
Query: 2149 FFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP 2208
FF G L+ +LDRE HE+ +L +D G PP ++T + + V D+NDN P
Sbjct: 1236 FFKMN---PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 1292
Query: 2209 NFSSL----SYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
F H V E P+ +T V A D D G++AE+ Y++ S
Sbjct: 1293 FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 323 bits (829), Expect = 1e-87
Identities = 345/1280 (26%), Positives = 542/1280 (42%), Gaps = 166/1280 (12%)
Query: 1317 FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIV 1376
F ++ DTG + T LDRE ++ ++ L + + V D NDH+P F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 1377 SSYDIEVLENQEPEVVYTV-LASDMDAGNNRAVEYHIIDGN------TDECFTINEMSG- 1428
S ++V E P + + +A D DAG Y ++ + F + +
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 1429 -----------------ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+L R LDRE+ + L I D G P R+ ++ +++RVLD
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-------TDEASGA 1524
ND+ P F Y+++VREDA+ G V + A D+D G NG Y + GA
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 1525 ------FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578
F ++ +SG ++ LDREA++ H ARD + TV + + V DVND
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATVRVSIAVLDVND 408
Query: 1579 NDPVLEQNPFDVFLS------------PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ 1626
N P + +FL+ P + +V D + T
Sbjct: 409 NRPAIHV----LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
Query: 1627 SMFSIDKYTGEIQFQQ---NPSSEYF-----PI--------WLQLKVTDQGIPARTTTGL 1670
S+ GE F P +F P+ L L TD G P +T
Sbjct: 465 GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
Query: 1671 LVIHMEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD----------------- 1712
L++ + D FS YK V+E GT ++ V A D
Sbjct: 525 LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 1713 ------SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG 1766
S+Q M ++ G ++ S+SG ++ + LD EV+ V+L V+A+ G
Sbjct: 585 APCNLGSLQSKMVHTAECGPS---FAIDSESGAISTI--RTLDREVQEAVELKVVAQDLG 639
Query: 1767 H---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
A C V++ + D NDN P F + +Y A+++E +QV A+D DSGL G IE
Sbjct: 640 EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
Query: 1824 YSILSG----NQEEAFQIDALSGVITTKAILDYELT-SSYSLIVQATDKGMPRLSNTTVI 1878
YS+ G +AF+ID G I +D E ++Y L+V+A D G LS +
Sbjct: 700 YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFV 757
Query: 1879 KVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPG-- 1935
+V + D+NDN P F PS V I++++ PG + +V D D S + A E PG
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD--SGIYGTVAYELIPGNV 815
Query: 1936 -TKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYT---EGALVVRVLDVNDNPPV 1991
+ F ID TG++ L L E T L++ D T + + + P
Sbjct: 816 SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
Query: 1992 FSQDFYQVTVPESIPVGYSVLTLSATD-LESNENISYRILSSSK--EFSIDPKNGTIFTI 2048
F + Y V E +P + T+ A + L S+E I YRI S +FSI P+ GTI T
Sbjct: 876 FERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTR 935
Query: 2049 SPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
P L +T V+A G P + T V I + D+N+ P F S + +S+
Sbjct: 936 KP-LDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
Query: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
G+ L D D R N + YSI S F ++ + +G L L SL
Sbjct: 994 PGTALYLARAEDRDSGR-NGLIRYSIASPQP-GVFAID----------RALGVLFLNGSL 1041
Query: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPN--FSSLSYHTHVKES-TPL 2225
L + A D G P ++ V+++ V++ ++ P+ F L Y V ES +P+
Sbjct: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPM 1100
Query: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
+ + + + + Y++ + F + TG +YL + DYE + V
Sbjct: 1101 TQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
Query: 2286 QA---SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD 2342
A D ++ S V+ V V D+ND++P F+ V E+ I I A+D D
Sbjct: 1161 FAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 1219
Query: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDK 2402
+G G+L Y ++S D F ++P TG++ LD E+ + +TV D+
Sbjct: 1220 SGKNGQLLYFLLS----------DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
Query: 2403 GDA--TASLVVWVDIEGIDEFEPIFTQ----DQYFFTLPEKNKDRQLIGRVEASDADAGI 2456
G A++ V+V + I++ P F Q + + E L+ V A D D G
Sbjct: 1270 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329
Query: 2457 DGVILYSLGTSSPFFSVNKT 2476
+ + YS+ ++ P KT
Sbjct: 1330 NAEVTYSVSSARPMPLKGKT 1349
Score = 309 bits (791), Expect = 3e-83
Identities = 246/684 (35%), Positives = 331/684 (48%), Gaps = 56/684 (8%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV
Sbjct: 684 QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 743
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
EAKDG GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII
Sbjct: 744 EAKDG------------GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791
Query: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------LYSPEVEILSAVNFSADK 250
NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG L E LS + + D
Sbjct: 792 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDG 851
Query: 251 EVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADG 310
+ ++ + F+ A +FE + F+ ++ + +
Sbjct: 852 GGLTAVINADVTIHIFQTT-----LAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNS 906
Query: 311 EAAARYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADV 363
Y + + G+ G I PL H + L V AQ G A + +V
Sbjct: 907 SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEV 965
Query: 364 TIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGK 423
I + F R + + P + + +A + + + + G
Sbjct: 966 NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV 1025
Query: 424 FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA--FL 481
F+I LG + L Q + LT++A+ ++ V V++ ++ P+ F
Sbjct: 1026 FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 1085
Query: 482 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGL-IRYSI-ASPQPGVFAIDRALGVLFLN 539
++ +S++ P T + +A R +RYS+ S +F I G ++L
Sbjct: 1086 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 1145
Query: 540 GSLGAGEQRELTLTLRA--EDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSES 597
+ + A + G + V+ V ++ ++SP TF H V ++V ES
Sbjct: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSP--TFLHDVLFLKVEES 1203
Query: 598 LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG----WIYLRRQFDYES 653
P + + A + + L + L D F + P TG W+ L R+
Sbjct: 1204 PVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKFFKMNPNTGELINWVALDREHRGHH 1260
Query: 654 TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV----LFLKVEESPVPQG 709
T P +N + V V V D NDN P F + L +KV E
Sbjct: 1261 EMTVLVTDRGSPP-----RNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 1315
Query: 710 VIGKITAIDMDSGKNGQLLYFLLS 733
++ + A D D G N ++ Y + S
Sbjct: 1316 LVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 293 bits (751), Expect = 1e-78
Identities = 354/1364 (25%), Positives = 551/1364 (40%), Gaps = 172/1364 (12%)
Query: 365 IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGD-- 419
+H++ + + + T V E +P D+ +G ++A P + F S D
Sbjct: 52 VHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP 111
Query: 420 LGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 479
L F +HP G IRT + LD E + LG+ +V I V DVND+ P
Sbjct: 112 LLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-----VQVEIRVNDVNDHSPR 166
Query: 480 FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---------------- 523
F S ++ +S+ +PPGTA L A D D+G Y++ P
Sbjct: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
Query: 524 ----------PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 572
PG + L ++ L L E L + A D G + LL + +
Sbjct: 227 TPGPLPSPLLPGSSSPLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSV- 629
V+++ ++ P FE Y+ V E P ++ + +A LGP +RYS+
Sbjct: 286 VLDENDNPP--VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPN---GFVRYSVRARQV 340
Query: 630 -----------DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 677
D+A F + +G + + R D E+ + V A + G V+T
Sbjct: 341 PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA--RDGGAEPEVATVR 398
Query: 678 VIVRVWDENDNSPTFLHDVLFL------KVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
V + V D NDN P VLFL +V E P + +++ D
Sbjct: 399 VSIAVLDVNDNRPAI--HVLFLTEGGVARVSEGARPGDYVARVSVSD------------- 443
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFS----GTDFAFSSDELQAFVLKSLFCELG 787
+DG + K + TG G + DG+ + S DFA L +F
Sbjct: 444 -ADGDWEKEDEATGELG----VGLGDGSISLSLEGGEGDFA-----LLPGGPPGVFFLCV 493
Query: 788 EGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 847
EG LDRE R +E+ ++ TD GSPP + + + V D+ND P F Q +
Sbjct: 494 EG------PLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ----QH 543
Query: 848 LHVKVLEGQPVNMLVTTVFAKDPDE--GNNAEVTYS-----------------VSSEDSS 888
V E +V V A D DE ++A + Y+ V + +
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
Query: 889 DHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIM 948
F ID+ +G I T L + + + + V+A D G PPL +V+I V ++ I
Sbjct: 604 PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
Query: 949 SQNIRHLIIPENLKPTKIMSLIKSSD---HLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005
+ + + I E+ + +SD L L+ ++ + F ID G
Sbjct: 664 WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723
Query: 1006 LFLSKELDYE-TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
+ +S+++D E + Y V D LS+ F+ +D+ED ND+ P F V S+
Sbjct: 724 ICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
Query: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
+ GT + A D D S + + Y + N ++ F I + G + L
Sbjct: 781 SDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNV-SSLFTIDSTTGIIYLTLPLSHLE 838
Query: 1125 IPTVILTVTASD----QAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVG 1180
T+ L V+A D AV D + + + TF+ V EDV
Sbjct: 839 STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL------VYEDVPED 892
Query: 1181 SLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVL 1240
S + + A +P + + Y I SG+ F + G + T PLD+E + +LTV
Sbjct: 893 SPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 1241 ALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGV 1300
A PA SS++ + +TV+DVND P F + E + + PG + A DRDSG
Sbjct: 952 AQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
Query: 1301 NSKLQFEI---MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357
N +++ I PG +F I+ G + L Q TL + D G +
Sbjct: 1011 NGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAA 1065
Query: 1358 TTILCTVEDENDHAPEFIVSS--YDIEVLENQEPEVVYTVLASDMDAGNNRA---VEYHI 1412
+L V ++ +H+P + Y +EV E+ P + + G RA + Y +
Sbjct: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP-MTQMLQTQAHPLGPQRAASPLRYSL 1124
Query: 1413 IDGNTDECFTINEMSGELSTTRALDRE--QISNFTLVILCSDLGDPPRSSVIHLQVRVLD 1470
F I +G + R D E Q NF + + G S + VRV D
Sbjct: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWD 1183
Query: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPM 1530
ND+SP+F V E V+ ++A+D D G NGQ YFL + F ++P
Sbjct: 1184 ENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK-FFKMNPN 1242
Query: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVNDNDPVLEQ--- 1585
+G L LDRE R H + + D +GS R+ T+ + V VTD+NDN P Q
Sbjct: 1243 TGELINWVALDREHRGHHEMTVLVTD---RGSPPRNATMAVYVSVTDINDNRPFFPQCLP 1299
Query: 1586 -NPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM 1628
V + P N V A D D G N V +S + + M
Sbjct: 1300 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
Score = 292 bits (748), Expect = 3e-78
Identities = 319/1213 (26%), Positives = 503/1213 (41%), Gaps = 138/1213 (11%)
Query: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
F ++ +G + T R LDRE+ +++ V + LG +V+ +++RV D NDHSP FP
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVA-ATLLG-----AVVQVEIRVNDVNDHSPRFPL 169
Query: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD------EASGAF------TID 1528
Q V E + GT + A D D GL Y L + +G F T
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 1529 PMSGTLKTSNT-------------LDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTD 1575
P+ L ++ LDRE + H A D + R+ + +++ V D
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG-RPRRTGLLSVELRVLD 288
Query: 1576 VNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ--------- 1626
NDN PV EQ+ + + ++ VRA D DLGPNG V +S Q
Sbjct: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
Query: 1627 -----SMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVT--DQGIP-----ARTTTGLLVIH 1674
+ F++++ +G ++ + P W QL V D G R + +L ++
Sbjct: 349 ALGDAAYFAVEELSGVVRVWR-PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
Query: 1675 MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSI---QDSMKYSIFSGNEDGVL 1731
+ + F V+E G + V D +D + G DG +
Sbjct: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
Query: 1732 SLCSKSGQ---------------LTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL 1776
SL + G+ L V+ P LD E R+ +L+++A +G L
Sbjct: 468 SLSLEGGEGDFALLPGGPPGVFFLCVEGP--LDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 1777 ---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSG---------------- 1817
+ D ND P F Q Y+ASVSE+ V+ V A+D D
Sbjct: 526 LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
Query: 1818 ---LNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
L L + + +F ID+ SG I+T LD E+ + L V A D G P LS
Sbjct: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
Query: 1875 TTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVD------LNSAFIFS 1927
T ++ + V D+NDN P F I E + G V+ D D + +
Sbjct: 646 TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYTEGALV-VRVLDV 1985
F P F ID + G + + + +D E + Y+LL++ D + A V V + DV
Sbjct: 706 FLSYEAPQA-FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN--ENISYRILSS--SKEFSIDPK 2041
NDN PVF+ Y ++ + G ++ + ATD +S ++Y ++ S F+ID
Sbjct: 765 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
Query: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
G I+ P+ L++ +T +V A DGG V I I EF Y
Sbjct: 825 TGIIYLTLPLSHLES-TTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
Query: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
+ ED S + T + + E + Y I SG+ F + + ++G
Sbjct: 884 LVYEDVPEDSPIGTVKAREPLNSSEPIF--YRISSGDLGGKFSI----------HPRLGT 931
Query: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
+ LD E L + A P SST V +I V+DVNDN P F S + +
Sbjct: 932 IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEV-NITVMDVNDNHPAFLRTSDEIRISQ 990
Query: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKF 2281
+TP G+ + + A DRD+G + I Y+I S + G F ++ GVL+L L + +
Sbjct: 991 TTPPGTALYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQREL 1049
Query: 2282 TLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341
TLT++A D + +V V++ +H+P + F V + +S +
Sbjct: 1050 TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
Query: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401
GP SP + S D +F I P TG I+ ++ DYE+ Y V A
Sbjct: 1110 PLGPQ-----RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
Query: 2402 KGDA---TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDG 2458
D S V V + ++ P F D F + E + +IG++ A D D+G +G
Sbjct: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
Query: 2459 VILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCT 2518
+LY L + FF +N G LI + L + EM ++ S + A+
Sbjct: 1225 QLLYFLLSDGKFFKMNPNTGE--LINWVALDREHRGHH---EMTVLVTDRGSPPRNATMA 1279
Query: 2519 VFVNVSFSSEGTP 2531
V+V+V+ ++ P
Sbjct: 1280 VYVSVTDINDNRP 1292
Score = 262 bits (670), Expect = 3e-69
Identities = 322/1307 (24%), Positives = 515/1307 (39%), Gaps = 174/1307 (13%)
Query: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDE-----SSGLLTTTCPLDYE 1230
D VG + + A EG LS + + + +LD+ +G++ T LD E
Sbjct: 80 DTLVGDIRAGLPAAQQQEGSG-----FFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE 134
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ + L L + + + V DVND +P F + V E PG
Sbjct: 135 RRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRL 188
Query: 1291 VEALDRDSGVNSK-----------------------------LQFEIMPGASFELFEINS 1321
A D D+G+ S L ++PG+S L +
Sbjct: 189 PVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL-- 246
Query: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDI 1381
++V LDRE L++ DGG P + ++ V DEND+ P F Y
Sbjct: 247 ---DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
Query: 1382 EVLENQEPEV-VYTVLASDMDAGNNRAVEYHI----IDG--------NTDECFTINEMSG 1428
V E+ +P V V A+D D G N V Y + + G F + E+SG
Sbjct: 304 AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
Query: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSS-- 1486
+ R LDRE + LV+ D G P + + + + VLD ND+ P+ L+
Sbjct: 364 VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGV 423
Query: 1487 --VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTS------- 1537
V E A G V +S D D ++ DEA+G + G++ S
Sbjct: 424 ARVSEGARPGDYVARVSVSDADG------DWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
Query: 1538 -----------------NTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDND 1580
LDRE+R + VA D ST + + V D+ND
Sbjct: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG-SPPLSTEETLLLRVADLNDQP 536
Query: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLD---------------------LGPNGTVV 1619
P+ Q + +S + + V A D D LG + +
Sbjct: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
Query: 1620 FSFAETQSMFSIDKYTGEIQFQQNPSSEYFP-IWLQLKVTDQGIPARTTTGLLVIHMEG- 1677
AE F+ID +G I + E + L++ D G P + T L+ I ++
Sbjct: 597 VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
Query: 1678 EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSG----NEDGVLS 1732
D + F +Y + E+ G + V A DS + ++YS++ G
Sbjct: 657 NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 1733 LCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIY 1792
+ GQ+ V + + + L+ + G A V V ++D NDN P F S Y
Sbjct: 717 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTY 776
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
S+S+ +I V ATD DSG+ G + Y ++ GN F ID+ +G+I L +
Sbjct: 777 VTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSH 836
Query: 1853 ELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE----------AVEITE 1902
+++ SL+V A D G T VI VT I+ P+E ++ E
Sbjct: 837 LESTTLSLMVSAQDGG----GLTAVINADVT-IHIFQTTLAPAEFERPKYTFLVYEDVPE 891
Query: 1903 DSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYE 1962
DS G + ++ +S IF + G KF+I G + K LD E
Sbjct: 892 DSPIGTVKAREPLN----SSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 947
Query: 1963 LLI--QISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
L + Q+ + + + + V+DVNDN P F + ++ + ++ P G ++ A D +
Sbjct: 948 LTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 1007
Query: 2021 SNEN--ISYRILSSSK-EFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRAL 2077
S N I Y I S F+ID G +F + + T L G +P +A
Sbjct: 1008 SGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP--QAA 1065
Query: 2078 TLVEIGIEDMNNYAPEFTVKS--YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
LV + + ++P +T + Y + +SE + ++ R + + YS+
Sbjct: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 1125
Query: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILA--SDSGCPPLSST 2193
F + PY G++ L D E++ ++ + A + G ST
Sbjct: 1126 PSVDSAMFGIR--------PY--TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 1175
Query: 2194 AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGN 2253
VI ++V D NDN P F V+ES I ++A D D+G + +++Y ++S
Sbjct: 1176 TVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG 1234
Query: 2254 EKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDDNDHAP 2312
+ F + NTG L LD E +TV +D + V+VSV D ND+ P
Sbjct: 1235 K--FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 1292
Query: 2313 QF----MFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
F V E P++ + ++ A D D G E+TYS+ S
Sbjct: 1293 FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 221 bits (564), Expect = 6e-57
Identities = 288/1203 (23%), Positives = 462/1203 (38%), Gaps = 175/1203 (14%)
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+DRE + A + L +EA DG R T L V+ + + D NDN PVF Y
Sbjct: 254 LDRE-EAAAHRLQIEAWDGGRPRRTGLLSVE----------LRVLDENDNPPVFEQDEYR 302
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYEL----IPGNVS--------SLFTIDSTT 231
++ ++ QPG E+ V ATD+D G G V Y + +PG S + F ++ +
Sbjct: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
Query: 232 GLY------SPEVE-----ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKF 280
G+ E + ++ A + A+ EV ++ + + +L V + A F
Sbjct: 363 GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVA-TVRVSIAVL----DVNDNRPAIHVLF 417
Query: 281 EASRGWFMRFKGRRHLHYL-KVQDEAASADGEAAARYVANLAKILGEGIIYLTL------ 333
G +G R Y+ +V A D E L LG+G I L+L
Sbjct: 418 LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
Query: 334 ------------------PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 375
PL L++ A D G + + + P
Sbjct: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
Query: 376 EFERPKYTFLVYEDVPEDSPIGTVKARE--------------------PLNSSEPIFYRI 415
F + Y V E + + V A + P N +
Sbjct: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
Query: 416 SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVN 474
+ + G F+I G I T + LD E Q V L V AQ LG P ++ V+ITV DVN
Sbjct: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
Query: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-----ASPQPGVFAI 529
DN P F R I++ P G A D DSG G I YS+ + P F I
Sbjct: 658 DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
Query: 530 DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHL 588
D G + ++ + E+ T L E + +A + V +E ++ P F
Sbjct: 718 DPHDGQICVSQDIDR-ERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP--VFNPS 774
Query: 589 VYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQ 648
Y +S+ P T+++ A + Y L P S++F I TG IYL
Sbjct: 775 TYVTSISDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
Query: 649 FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQ 708
+ + T + V A G ++ V + ++ F V E
Sbjct: 834 LSHLESTTLSLMVSAQ-DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED 892
Query: 709 GVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGPAGTIYVITWADGAAAFSGT 765
IG + A + + + +++ +S G F ++P G T +
Sbjct: 893 SPIGTVKA--REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL------------ 938
Query: 766 DFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 825
E Q V+ ++ +LG S P ++ V
Sbjct: 939 -----DHETQPVVVLTVQAQLG----------------------------SAPACSSTEV 965
Query: 826 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE 885
++V D+NDN P F + +++ + P + A+D D G N + YS++S
Sbjct: 966 NITVMDVNDNHPAFLRTSD----EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
Query: 886 DSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945
F ID G + L + +++ A DQGV P QA + + + + K
Sbjct: 1022 QPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP---QAALLVLTVVIEKRE 1077
Query: 946 AIMSQNIRHLI----IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDS 1001
S HL+ + E+L P M ++ Q L +S+ F I
Sbjct: 1078 HSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRP 1137
Query: 1002 STGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIV 1061
TG ++L ++ DYE+T Y FRV + + + + V D+ND+SP+F +++
Sbjct: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF 1197
Query: 1062 ISVEEN-VPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRL 1120
+ VEE+ VP G + + D G N ++ Y++ S F ++P+ G L+ L
Sbjct: 1198 LKVEESPVPQGVIGKITAIDMDSGK--NGQLLYFLLSDG---KFFKMNPNTGELINWVAL 1252
Query: 1121 DRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF---ISFPNAHVK--E 1175
DRE +TV +D+ + R ++ + + D+ND+ P F + HVK E
Sbjct: 1253 DREHRGHHEMTVLVTDRG---SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE 1309
Query: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235
V LV + A DPDEG N +VTYS+ S L + +C +T
Sbjct: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSAR---PMPLKGKTAFGKQSCKKQTNKQTNK 1366
Query: 1236 ILT 1238
ILT
Sbjct: 1367 ILT 1369
Score = 179 bits (453), Expect = 5e-44
Identities = 295/1283 (22%), Positives = 488/1283 (38%), Gaps = 194/1283 (15%)
Query: 143 DEQRMTHLALVKGGL-SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLA 201
D +R H + V L A V + + DVND+ P F + +S+ + PGT +A
Sbjct: 132 DRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191
Query: 202 TDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLP 261
D D+G++ T Y L+ + L L + + L++ L
Sbjct: 192 HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVL- 250
Query: 262 LLRHFKKVERDEEAAEK-KFEASRGWFMRFKGRRHLHYLKVQDE--------------AA 306
++++R+E AA + + EA G R G + L+V DE A
Sbjct: 251 ----LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE-LRVLDENDNPPVFEQDEYRAAV 305
Query: 307 SADGEAAA------------------RYVANLAKILGEG-------------------II 329
D + A RY ++ G G ++
Sbjct: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
Query: 330 YLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 389
+ PL L+V A+DGG V V+I + RP L +
Sbjct: 366 RVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD-----VNDNRPAIHVLFLTE 420
Query: 390 -----VPEDSPIGTVKAREPLNSSEPIFYR--ISSGDLG----------------GKFSI 426
V E + G AR ++ ++ + + ++G+LG G F++
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
Query: 427 ----HPRLGTIRTRKPLDHETQPVV-VLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481
P + + PLD E++ + +L V GS P + + + V D+ND P F
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
Query: 482 RTSDEIRISQTTPPGTALYLARAEDRD--SGRNGLIRYSI-------------------A 520
+ + +S+ PGT + A D D + +RY++ A
Sbjct: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
Query: 521 SPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REH 579
P FAID G + +L Q + L + A+D G P +A ++++ ++ ++
Sbjct: 601 ECGPS-FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDN 659
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS----AMFG 635
P F VY ++E LQ A + YSL S F
Sbjct: 660 EP--IFWRQVYNATIAEHAPVGHCFLQVTASD-ADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 636 IRPYTGWIYLRRQFDYE-STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH 694
I P+ G I + + D E TY+ V A +DG + V V + D NDN P F
Sbjct: 717 IDPHDGQICVSQDIDRERDPATYDLLVEA---KDGGGLSAQAFVRVDLEDVNDNHPVFNP 773
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
+ + P I + A D DSG G + Y L+ G + G IY+
Sbjct: 774 STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGIIYL-- 830
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
L++ L + G L ++ + H T L
Sbjct: 831 -------------TLPLSHLESTTLSLMVSAQDGGGLT--AVINADVTIHIFQTTLAPAE 875
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
P+ T VY V P + + TV A++P +
Sbjct: 876 FERPK-YTFLVYEDV---------------------------PEDSPIGTVKAREP-LNS 906
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
+ + Y +SS D F I G IRT L ++ +P ++V A G P V
Sbjct: 907 SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEV 965
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD 994
NI V+ ++ + + I + P + L ++ D NG + +SI A +
Sbjct: 966 NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR-DSGRNGLIRYSI-ASPQP 1023
Query: 995 GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
G F ID + G LFL+ L + D + ++ + L++ +E + +HSPS
Sbjct: 1024 GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLVLTVVIE-KREHSPS 1081
Query: 1055 FQDELIVISVE--ENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
+ E +V VE E++ T + A S ++Y +E + + F I P G
Sbjct: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP-SVDSAMFGIRPYTG 1140
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV--ILDVNDHNPTFI-SFP 1169
+ + D ES T V A D L++++ ++ + D ND++PTF+
Sbjct: 1141 WIYLRRQFDYESTQTYNFRVFAWIP----EDGFLQNVSTTVIVRVWDENDNSPTFLHDVL 1196
Query: 1170 NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDY 1229
V+E ++ ITA D D G+NG++ Y +LS + F ++ ++G L LD
Sbjct: 1197 FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDR 1254
Query: 1230 EMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL----YEASVKENQNPG 1285
E + H +TVL D G+P +++ + V+V D+ND P F Q L V E Q
Sbjct: 1255 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 1314
Query: 1286 EFVTRVEALDRDSGVNSKLQFEI 1308
VT V A D D G N+++ + +
Sbjct: 1315 MLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 112 bits (279), Expect = 7e-24
Identities = 132/522 (25%), Positives = 215/522 (41%), Gaps = 69/522 (13%)
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW----TRENTY 2129
L A+ VEI + D+N+++P F + S L +SE + G+ D D T+ T
Sbjct: 147 LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTL 206
Query: 2130 VEYSIISGNSQNNFHV----------ETKFFHSEYPYKQVGYLVLLHSLDREASASHELV 2179
V+ S + + F S P + + LVLL LDRE +A+H L
Sbjct: 207 VQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLD-LVLLRRLDREEAAAHRLQ 265
Query: 2180 ILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT 2239
I A D G P + + ++VLD NDNPP F Y V+E G+ + V A DRD
Sbjct: 266 IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDL 325
Query: 2240 GSHAEIIYNIISGNEKG------------HFYLEENTGVLYLIKPLDYEKMTKFTLTVQA 2287
G + + Y++ + G +F +EE +GV+ + +PLD E L V+A
Sbjct: 326 GPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA 385
Query: 2288 SDA-EKKHFSFAVVFVSVLDDNDHAPQ----FMFSSFSCIVPENLPISSTICSINALDFD 2342
D + + V ++VLD ND+ P F+ V E + ++ D D
Sbjct: 386 RDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD 445
Query: 2343 AG------PYGELTYSIVSPCFLTHGMSYDHDLFLID---PLTGDIHAKQILDYENGNKY 2393
GEL + + D L+ P + + LD E+ + Y
Sbjct: 446 GDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLY 505
Query: 2394 CLTVQAKDKGDATASL--VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASD 2451
L + A D G S + + + +++ P+F+Q Y ++ E ++ V ASD
Sbjct: 506 ELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASD 565
Query: 2452 AD-AGIDGVILY----------SLGT----------SSPFFSVNKTNGNIYLIRALPLIK 2490
AD AG D L +LG+ P F+++ +G I IR L
Sbjct: 566 ADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL---- 621
Query: 2491 SQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPL 2532
++ +E+K++A A+C V + V ++ P+
Sbjct: 622 -DREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPI 662
Score = 46.2 bits (108), Expect = 5e-04
Identities = 44/150 (29%), Positives = 69/150 (46%), Gaps = 24/150 (16%)
Query: 69 ENAKPVKET-EVTASDADSGLYGFIEYSLY--------DGFLSYEAPQAFRIDPHDGQIC 119
E+A+P E V A+D D G GF+ YS+ G + F ++ G +
Sbjct: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
Query: 120 VSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP---- 175
V + +DRE A + L+VEA+DG + +A V+ V + + DVNDN P
Sbjct: 367 VWRPLDREAQ-AWHQLVVEARDGGAE--PEVATVR--------VSIAVLDVNDNRPAIHV 415
Query: 176 VFNPSTYVTSISDETQPGTEIINVLATDQD 205
+F V +S+ +PG + V +D D
Sbjct: 416 LFLTEGGVARVSEGARPGDYVARVSVSDAD 445
Score = 45.4 bits (106), Expect = 8e-04
Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 40/161 (24%)
Query: 118 ICVSQDIDRE-RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPV 176
+CV +DRE RD Y+LL+ A D LS + + + + D+ND P+
Sbjct: 491 LCVEGPLDRESRD--LYELLLVATDAGSPP----------LSTEETLLLRVADLNDQPPL 538
Query: 177 FNPSTYVTSISDETQPGTEIINVLATDQDSG------IYGTVAYELIPGNVSSL------ 224
F+ Y S+S+ PGT ++ V A+D D + TV P N+ SL
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
Query: 225 -------FTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEM 258
F IDS +G +S + + D+EV ++E+
Sbjct: 599 TAECGPSFAIDSESG-------AISTIR-TLDREVQEAVEL 631
Score = 36.6 bits (83), Expect = 0.37
Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 28/163 (17%)
Query: 62 IVFRSQEENAKPVKET-EVTASDADSGLYGFIEYSLY-DGFLSYEAPQAFRIDPHDGQIC 119
++F EE+ P ++TA D DSG G + Y L DG + F+++P+ G++
Sbjct: 1195 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG-------KFFKMNPNTGELI 1247
Query: 120 VSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVF 177
+DRE MT L +G +A V V + D+NDN P F
Sbjct: 1248 NWVALDREHR-------------GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
Query: 178 N---PSTYVTSISDETQPGTEII-NVLATDQDSGIYGTVAYEL 216
P + E QP ++ V A D D G V Y +
Sbjct: 1295 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 863 bits (2229), Expect = 0.0
Identities = 727/2530 (28%), Positives = 1142/2530 (45%), Gaps = 197/2530 (7%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+V ASD DSG G I Y++ +G AF I P DGQ+ + ++DRE Y L+V
Sbjct: 1017 KVQASDKDSGANGEIAYTIAEG----NTGDAFGIFP-DGQLYIKSELDRELQDR-YVLMV 1070
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
A D + LSA V V LEDVNDN P+FN + Y +E + G+ +
Sbjct: 1071 VASDRAVEP----------LSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVG 1120
Query: 198 NVLATDQDSGIYGTVAYEL-----------IPGNVSSLFTIDSTTGLYSPEVEILSAVNF 246
V A D+D G G V Y I G +++ D + + + S
Sbjct: 1121 KVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVI 1180
Query: 247 SADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAA 306
+ D+ + L+ + + K + + K F + + L+V
Sbjct: 1181 ATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQAT---ISESAANLTQVLRVSASDV 1237
Query: 307 SADGEAAARYVA-------NLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVI 359
Y A G + L L + + SL++ A D G +
Sbjct: 1238 DEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNS 1297
Query: 360 NADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-----IFYR 414
+ I I F PK T V DV E+ IG + + S+ ++Y
Sbjct: 1298 TCTLNIDILDENDNTPSF--PKSTLFV--DVLENMRIGELVSSVTATDSDSGDNADLYYS 1353
Query: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDV 473
I+ + G FSI P G+I K LD ETQ + L + A+ G P S+ V I V D
Sbjct: 1354 ITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDF 1413
Query: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP--GVFAIDR 531
NDN P+F I + P GT++ A D D+ NG + Y+I P F ID
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDE 1473
Query: 532 ALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQA---ALLVLTVVI-EKREHSPSWTFEH 587
G ++ N + LT++A DQ V + AL +T+++ + ++ P +
Sbjct: 1474 VKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMF---- 1529
Query: 588 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLR 646
+ Q ++ S + + T P A+ + Y + D+ F + Y+G + +
Sbjct: 1530 -ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIING-DTDTFIVDRYSGDLRVA 1587
Query: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
S YN V A + G + STT + + D + + E P+
Sbjct: 1588 SAL-VPSQLIYNLIVSA--TDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPI 1644
Query: 707 PQGVIGKITAIDMDSGKNGQLLYFLLSD-------GKFFKMNPNTGPAGTIYVITWADGA 759
VI A G + Y+++S G+ F + +TG T ++ GA
Sbjct: 1645 GTNVISIEAA--SPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGA 1702
Query: 760 AAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPR 819
+ L++ A+++ + PR
Sbjct: 1703 CLY----------------------------LVDVYAIEKST--------------AFPR 1720
Query: 820 NATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVT 879
V +++ DINDN P FP + + + +G + L A D DEG NA VT
Sbjct: 1721 TQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT----AMDADEGANALVT 1776
Query: 880 YSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV-VNIQV 938
Y++ S + D F+ID +G++ T L + R Y + V A D LQ + +NI V
Sbjct: 1777 YTIIS-GADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG----LQSSDMRINITV 1831
Query: 939 IPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFE 998
++ S+ + IPE+ P +++ I ++D NG++ + + DD+DG F
Sbjct: 1832 SDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDD-DSGVNGEITYIVNEDDEDGIFF 1890
Query: 999 IDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDE 1058
++ TG L++ LDYE +Y+ V D + T+ + ++ D ND+ P F
Sbjct: 1891 LNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFT---TIRVYFNILDVNDNPPIFSLN 1947
Query: 1059 LIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTV 1117
S+ EN+P+G+ V VFN D DDG +NS++ Y I S + F + + G L +
Sbjct: 1948 SYSTSLMENLPVGSTVLVFNVTDADDG--INSQLTYSIASGD-SLGQFTVDKN-GVLKVL 2003
Query: 1118 SRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDV 1177
LDRES L V D R + I++LDVND+ PTF+S ++ E+
Sbjct: 2004 KALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENT 2063
Query: 1178 TVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHIL 1237
+ ++V A DPD G N + Y++L+ N F + G + T LD E + + L
Sbjct: 2064 PIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK-FSIGTIDGEVRLTGELDREEVSNYTL 2122
Query: 1238 TVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD 1297
TV+A D G P+LSSS + V VLD+ND P+F Q LY+ + EN G + +V A D D
Sbjct: 2123 TVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGD 2182
Query: 1298 SGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357
G N ++++ I+ G + + F I+S TG + LDRE + L V D G + T
Sbjct: 2183 EGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDT 2242
Query: 1358 TTILCTVEDENDHAPEFIVSSYDIEVLENQE--PEVVYTVLASDMDAGNNRAVEYHIIDG 1415
+T+ + D ND P F +S Y + V EN P + V+A D D G+N + Y + G
Sbjct: 2243 STVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGG 2302
Query: 1416 NTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHS 1475
N D FT++ SGEL T++LDRE F L+I +D G P + + V V D ND+
Sbjct: 2303 NEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNV 2361
Query: 1476 PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLK 1535
P+F + Y +++ EDA GT VL+++A D D N + FTI+P +G +
Sbjct: 2362 PTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII---GGNSQFTINPSTGQII 2418
Query: 1536 TSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPE 1595
TS LDRE + +T V D S++ + V VTDVNDN P + +P+ +
Sbjct: 2419 TSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSP 2478
Query: 1596 SPTNQTTVIVRADDLDLGPNGTVVFSFAETQS-MFSIDKYTGEIQFQQNPSSEYFPIWLQ 1654
+ V D D+GPN + +S + S F ID G I P + +
Sbjct: 2479 TLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIM-AAGPLNGASEVTFS 2537
Query: 1655 LKVTDQG-IPARTTTGLLVIHMEGEDV-KISFSHHLYKGLVTENCEAGTSIVTVKAFAPD 1712
+ V D G P +T + V + D K+ + + EN + + T+ +
Sbjct: 2538 VHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTF--MFPENQPVSSLVTTITGSSLR 2595
Query: 1713 SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH---RA 1769
+ M Y I SGN + +GQ+++ +P LDFE + + + A G +
Sbjct: 2596 G--EPMSYYIASGNLGNTFQIDQLTGQVSISQP--LDFEKIQKYVVWIEARDGGFPPFSS 2651
Query: 1770 YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSG 1829
Y K+ + + D NDN+P F++ + + + E+ L ++ V A D DSG NG ++Y I++G
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNG 2710
Query: 1830 NQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNA 1889
N E +F I+ +G I + LD E S Y L ++++DKG P S + + + + D NDNA
Sbjct: 2711 NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNA 2770
Query: 1890 PAFLPSEAVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVV 1947
P F + + E+S G VT V+ D D+ N+ +S S P F I+ +TG +
Sbjct: 2771 PRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP---FTINPSTGDI 2827
Query: 1948 VLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPV 2007
V+ + L+ E+ Y + + DS + + V D+NDN P FS+ Y + PE +
Sbjct: 2828 VISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEI 2887
Query: 2008 GYSVLTLSATDLE--SNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDT-------IS 2058
G V + ATD + SN + Y I S S+ F I+ G IF + + I+
Sbjct: 2888 GSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNIN 2947
Query: 2059 TTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSN 2118
F+V +SD G P L + T V I I D N+ AP+F Y ++++ VG+ L+ +
Sbjct: 2948 RHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTA 3007
Query: 2119 IDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHEL 2178
ID N+ VEY I + N F ++ G++ + SL + + + +
Sbjct: 3008 IDDKDFGLNSEVEYFISNDNHLGKFKLDN----------DTGWISVASSLISDLNQNFFI 3057
Query: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD 2238
+ A D G PPLSS A + I V + N + P FS + ES +GS + VSA DRD
Sbjct: 3058 TVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRD 3117
Query: 2239 TGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE-KKHFSF 2297
+ I Y+I SGNE+G F + +TG+L L K LDYE K +T+ A D +
Sbjct: 3118 AAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGY 3177
Query: 2298 AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPC 2357
V V+V+D ND++P F+ + V EN P +T+ +NA D D+G + Y++
Sbjct: 3178 CSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTV---- 3233
Query: 2358 FLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIE- 2416
S D DLF+IDP TG I + LD+E Y LTV+A + D V+I+
Sbjct: 3234 -----QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQL 3288
Query: 2417 -GIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSV 2473
G +E+ P F Y+F + E ++G V ASD D G DG + Y + + F +
Sbjct: 3289 KGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI 3348
Query: 2474 NKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLA 2533
NK G IY+ L KE+ + +K++A + S V VNV+ P
Sbjct: 3349 NKKTGQIYVSGIL-----DREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPI 3403
Query: 2534 VFASSFSISL 2543
+ +S+ +
Sbjct: 3404 FTLNIYSVQI 3413
Score = 711 bits (1836), Expect = 0.0
Identities = 678/2531 (26%), Positives = 1127/2531 (44%), Gaps = 258/2531 (10%)
Query: 61 AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRID-----PHD 115
+IV +E+++ + TA+D+D G G +++ Y EA + FR+D +
Sbjct: 139 SIVVTFKEDSSSGRQVILDTATDSDIGSNG-VDHRSYRIIRGNEAGR-FRLDITLNPSGE 196
Query: 116 G---QICVSQDIDRERDPATYDLLVEAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVN 171
G + +DRE P Y LLVE +D G+ +R +L V V ++D+N
Sbjct: 197 GAFLHLVSKGGLDREVTPQ-YQLLVEVEDKGEPKRRGYLQ-----------VNVTVQDIN 244
Query: 172 DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTT 231
DN PVF S Y + ++ G+ ++ V A D D G + Y L + + F +D T
Sbjct: 245 DNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPET 302
Query: 232 GLYSPEVEILSAVNFSADKE---VMNSLEMFLP--------LLRHFKKVERDEEAAEKKF 280
GL + + ++F A ++ + +++ +P L++ + D + F
Sbjct: 303 GL----ITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYF 358
Query: 281 EASRGWFMRFKGRRH---LHYLKVQD-EAASADGEAAAR---------YVANLAKILGEG 327
A+ + + + + L V D ++ +A+G + + + +K+
Sbjct: 359 PATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLS 418
Query: 328 IIYLTLPLSHLESTTLSLMVSAQDGGGLT--AVINA-----DVTIHIFQTTLAPAEFERP 380
+I + L + +L VS D G A + A + I + P F +
Sbjct: 419 LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQ 478
Query: 381 KYTFLVYEDVPEDSPIGTVKAREP---LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 437
Y + E+ P S + + A + LN++ + Y I SG+ G F I G + T
Sbjct: 479 VYRVNLSEEAPPGSYVSGISATDGDSGLNAN--LRYSIVSGNGLGWFHISEHSGLVTTGS 536
Query: 438 P--LDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSD-EIRISQTT 493
LD E +VL + A+ G P S ++ +T++DVND P F + ++ + +
Sbjct: 537 SGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENA 596
Query: 494 PPGTALYLARAEDRDSGRNGLIRYSI--ASPQPGVFAIDRALGVLFLNGSLGAGEQRELT 551
P GT L + RA D D G NG +R+S+ A F +D G L SL EQ +
Sbjct: 597 PTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYS 656
Query: 552 LTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
L + A D G PQ+++ + V +++ ++SP F + Y + E+ P + T +
Sbjct: 657 LLVLATDLGSPPQSSMARINVSLLDINDNSP--VFYPVQYFAHIKEN-EPGGSYITTVSA 713
Query: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF 670
++YS+ D + F + +G I R D E Y ++ A + G
Sbjct: 714 TDPDLGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVA--TDGGN 770
Query: 671 LQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY 729
LQ+ + ++ + V D DN P F V E+ +G ++A MD N L
Sbjct: 771 LQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLI 830
Query: 730 FLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEG 789
F +N TG T VI
Sbjct: 831 TTGDQKGMFAINQVTGQLTTANVI------------------------------------ 854
Query: 790 ELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELH 849
DRE + +++ V+ + G TM V ++V D+NDN P F Q +
Sbjct: 855 --------DREEQSFYQLKVVAS--GGTVTGDTM-VNITVKDLNDNSPHFLQAIES---- 899
Query: 850 VKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYD 909
V V+E + A DPDEG N V YS+ ++ + F I+ NG I L
Sbjct: 900 VNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK-QNPKNLFAINEKNGTISLLGPLDV- 957
Query: 910 YRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSL 969
+ SY++ ++A+D GVP L ++ + V ++ + Q + + E+
Sbjct: 958 HAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFK 1017
Query: 970 IKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDH 1029
+++SD NG++ ++I + F I G L++ ELD E Y+ V+ +D
Sbjct: 1018 VQASDK-DSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDR 1075
Query: 1030 SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNS 1089
+ LS+TV +++ +ED ND+ P F EE G+ V +A D D N
Sbjct: 1076 AVE-PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFG-PNG 1133
Query: 1090 RIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESI------PTVILTVTASDQAVNVTD 1143
++Y E P F +H G + + DRES+ TV A+DQ +
Sbjct: 1134 EVRYSFEMVQPD---FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPL 1190
Query: 1144 RRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYS 1202
+ T + + D+ND+ P F+ F A + E + V ++A D DEG NG + YS
Sbjct: 1191 KD--QATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYS 1248
Query: 1203 ILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
I+ GNE F +D +SG +T LDYE + L + A+D GT L+S+ TL + +LD
Sbjct: 1249 IIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDE 1308
Query: 1263 NDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSD 1322
ND P F + V EN GE V+ V A D DSG N+ L + I + F I+ +
Sbjct: 1309 NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPN 1368
Query: 1323 TGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIE 1382
TG + LD E Q ++ L + +D G P SST +++ V D ND+ P F
Sbjct: 1369 TGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKS 1428
Query: 1383 VLEN-QEPEVVYTVLASDMDAGNNRAVEYHIID----GNTDECFTINEMSGELSTTRALD 1437
++EN V +V A D DA N + Y II GN FTI+E+ G + T +D
Sbjct: 1429 IVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH---FTIDEVKGTIYTNAEID 1485
Query: 1438 REQISNFTLVILCSDLGDP---PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED--AE 1492
RE + F L + +D P R ++ ++ + V D ND+ P F + Q+++ D A
Sbjct: 1486 REFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS---QNALAADPSAV 1542
Query: 1493 VGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSA 1552
+G+V+ + A D DEG NG+ EY + + + F +D SG L+ ++ L SQ ++
Sbjct: 1543 IGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASAL---VPSQLIYNL 1599
Query: 1553 V--ARDCSIQGSRSTTVIIKV-------------YVTDVNDNDPVLEQNPFDVFLSP--- 1594
+ A D + +STT + + Y+T + + +P+ SP
Sbjct: 1600 IVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGS 1659
Query: 1595 ESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQ----FQQNPSSEYFP 1650
E+P V VR ++ +G +F+I ++TG IQ + + +
Sbjct: 1660 EAPVEYYIVSVRCEEKTVG-------------RLFTIGRHTGIIQTAAILDREQGACLYL 1706
Query: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFA 1710
+ + P + + + D F + V EN G+ I+ + A
Sbjct: 1707 VDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMD 1766
Query: 1711 PDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRA 1769
D +++ Y+I SG +D + +SG L + LD E R++ L+V A+ +
Sbjct: 1767 ADEGANALVTYTIISGADDS-FRIDPESGDLIA--TRRLDRERRSKYSLLVRADDGLQSS 1823
Query: 1770 YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSG 1829
++ + + D ND++P F + +Y + E + + V + ATD DSG+NG I Y +
Sbjct: 1824 DMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNED 1883
Query: 1830 NQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKV--QVTDIND 1887
+++ F ++ ++GV +LDYE+ Y L V+A D G T I+V + D+ND
Sbjct: 1884 DEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG----GQFTTIRVYFNILDVND 1939
Query: 1888 NAPAF-LPSEAVEITEDSLPG--VIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNT 1944
N P F L S + + E+ G V+V +V+ D +NS +S A + G +F +D+N
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLG-QFTVDKN- 1997
Query: 1945 GVVVLVKTLDFEEMTEYELLIQISD-----SVHYTEGALV-VRVLDVNDNPPVFSQDFYQ 1998
GV+ ++K LD E + Y L++Q+ D + +T A V + +LDVNDNPP F
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSP-KL 2056
Query: 1999 VTVPESIPVGYSVLTLSATDLESNEN--ISYRILSS-SKEFSIDPKNGTIFTISPVLLLD 2055
+PE+ P+ V ATD +S N I Y +L+ +FSI +G + ++ L +
Sbjct: 2057 TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEV-RLTGELDRE 2115
Query: 2056 TISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVT 2115
+S V A+D G P L + T V + + D+N+ P F Y + ++E+ L G+ ++
Sbjct: 2116 EVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQ 2175
Query: 2116 FSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASAS 2175
D D N V Y I++GN+ F +++ G + + LDRE + +
Sbjct: 2176 VFAADGD-EGTNGQVRYGIVNGNTNQEFRIDS----------VTGAITVAKPLDREKTPT 2224
Query: 2176 HELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKEST-PLGSHITVVSA 2234
+ L + A+D G P + T+ +SI +LD+ND P F Y +V E+ L I V A
Sbjct: 2225 YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVA 2284
Query: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKH 2294
D D GS++++ Y + GNE F L +G L + + LD E +F L + A+D+
Sbjct: 2285 RDDDRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPA 2343
Query: 2295 FSFAVVFVSVLDD-NDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSI 2353
+ ++DD ND+ P F ++ +PE+ P + + +NA D DA +
Sbjct: 2344 LTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR--- 2400
Query: 2354 VSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD---ATASLV 2410
+ G S F I+P TG I +LD E + Y L V D G ++S
Sbjct: 2401 -----IIGGNSQ----FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTS 2451
Query: 2411 VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL-GTSSP 2469
V V + +++ P F Y +P + V +DAD G + + YSL G +S
Sbjct: 2452 VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE 2511
Query: 2470 FFSVNKTNGNI 2480
F ++ G I
Sbjct: 2512 KFHIDPLRGAI 2522
Score = 697 bits (1798), Expect = 0.0
Identities = 637/2317 (27%), Positives = 1034/2317 (44%), Gaps = 194/2317 (8%)
Query: 63 VFRSQEENAKPVKET--EVTASDADSGLYGFIEYSLYDGFLSYEAPQA--FRIDPHDGQI 118
+F+S EN P+ + VTA D D+ + G + Y++ + P+ F ID G I
Sbjct: 1425 IFKSIVENI-PIGTSVISVTAHDPDADINGQLSYTIIQ-----QMPRGNHFTIDEVKGTI 1478
Query: 119 CVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFN 178
+ +IDRE ++L V+A D T +K V + + D+NDN P+F
Sbjct: 1479 YTNAEIDREF-ANLFELTVKANDQAVPIETRRYALKN-------VTILVTDLNDNVPMFI 1530
Query: 179 PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEV 238
S + G+ + ++A D D G G + YE+I G+ + F +D YS ++
Sbjct: 1531 -SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDT-FIVDR----YSGDL 1584
Query: 239 EILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHY 298
+ SA+ V + L L + ER + E F +++
Sbjct: 1585 RVASAL-------VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITI 1637
Query: 299 LK---------VQDEAASADGEAAA--RYVANLA---KILGE--------GIIYLTLPLS 336
LK + EAAS G A Y+ ++ K +G GII L
Sbjct: 1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697
Query: 337 HLESTTLSLM--VSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 394
+ L L+ + + A+V I + P F V E++ + S
Sbjct: 1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757
Query: 395 PIGTVKAREPLNSSEPIF-YRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA 453
I + A + + + Y I SG F I P G + + LD E + L V+A
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA 1816
Query: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
G S +NITV DVND+ P F R I + T PG+ + A D DSG NG
Sbjct: 1817 DDGLQS--SDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNG 1874
Query: 514 LIRYSI-ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 572
I Y + + G+F ++ GV L L Q+ LT+RAED G + V
Sbjct: 1875 EITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ-FTTIRVYFN 1933
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA 632
+++ ++ P ++ Y + E+L + +L S L YS+
Sbjct: 1934 ILDVNDNPPIFSLNS--YSTSLMENLPVGSTVLVFNVTD-ADDGINSQLTYSIASGDSLG 1990
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRV----FAWIPEDGFLQNVSTTVIVRVWDENDN 688
F + G + + + D ES YN V IP F ++I+ D NDN
Sbjct: 1991 QFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL--DVNDN 2047
Query: 689 SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAG 748
PTFL L E +P+ V+ K A D DSG N + Y LL+ P G
Sbjct: 2048 PPTFLSPKLTYIPENTPIDT-VVFKAQATDPDSGPNSYIEYTLLN------------PLG 2094
Query: 749 TIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMT 808
+ I DG +G LDRE ++ +T
Sbjct: 2095 NKFSIGTIDGEVRLTGE-------------------------------LDREEVSNYTLT 2123
Query: 809 VLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAK 868
V+ TD+G P +++ V V V DINDN P F Q L E++ L G + VFA
Sbjct: 2124 VVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDI----IQVFAA 2179
Query: 869 DPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPL 928
D DEG N +V Y + + +++ F+ID+ G I L + P+Y ++V ATD+G P
Sbjct: 2180 DGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR 2239
Query: 929 QGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLK--PTKIMSLIKSSDHLQQHYNGKLHF 986
+ V+I ++ ++ + + + +PENL P I+ ++ D + N KL +
Sbjct: 2240 TDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD--DRGSNSKLSY 2297
Query: 987 SIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVE 1046
+ ++D F + S++G+L +++ LD ET ++ + TD S + +L+ T +++ V+
Sbjct: 2298 VLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATD-SGSPALTGTGTINVIVD 2355
Query: 1047 DQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFL 1106
D ND+ P+F + ++ E+ P GT V + NA D D S N+ I+ G + F
Sbjct: 2356 DVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS-KNAVIRII-----GGNSQFT 2409
Query: 1107 IHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTF 1165
I+PS G ++T + LDRE+ L V SD + L S T+ +V + DVND+ P F
Sbjct: 2410 INPSTGQIITSALLDRETKDNYTLVVVCSDAG---SPEPLSSSTSVLVTVTDVNDNPPRF 2466
Query: 1166 ISFPNA-HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224
P H+ GS V +T D D G N ++ YS LSG + F +D G +
Sbjct: 2467 QHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRNSEKFHIDPLRGAIMAA 2525
Query: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
PL+ + +V D G+ + S T+TV ++ D P + ENQ
Sbjct: 2526 GPLNGASEVT--FSVHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQPV 2582
Query: 1285 GEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRV 1344
VT + S + + I G F+I+ TG+V + LD E + + + +
Sbjct: 2583 SSLVTTITG---SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWI 2639
Query: 1345 LVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGN 1404
RDGGFP SS + TV D ND+AP F + E+LEN P + TV A D D+G
Sbjct: 2640 EARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGP 2699
Query: 1405 NRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHL 1464
N ++Y I++GN + F+IN +GE+ + R LDRE++S++ L I SD G P +S+ + +
Sbjct: 2700 NGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKV 2759
Query: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA 1524
+ +LD ND++P F + + + V E++ +G V ++ D+D G+N + Y + D AS
Sbjct: 2760 MINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMD-ASLP 2817
Query: 1525 FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
FTI+P +G + S L+RE ++ A D S T ++VTD+NDN P
Sbjct: 2818 FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVT----IFVTDINDNAPRFS 2873
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+ + + + V A D D G NG V + F I+ TGEI +Q
Sbjct: 2874 RTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQIL 2933
Query: 1645 SSEYFPIWLQLKV---------TDQGIPARTTTGLLVIH-MEGEDVKISFSHHLYKGLVT 1694
+ + + + +D+G P+ + + I+ ++ D F Y VT
Sbjct: 2934 KYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVT 2993
Query: 1695 ENCEAGTSIVTVKAFAPD--SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV 1752
+N + GT ++ V A + ++Y I + N G L + +G ++V D +
Sbjct: 2994 KNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISD--L 3051
Query: 1753 RNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQV 1809
+ V A+ G+ + V + + +EN ++P F QS A++ ES + V V
Sbjct: 3052 NQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV 3111
Query: 1810 FATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
A D D+ +NGLI+YSI SGN+E F I++ +G++T LDYEL + + + A D G
Sbjct: 3112 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW 3171
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+ + V V D+NDN+P FL + + E++ G V H++ D D + + ++
Sbjct: 3172 VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAY 3231
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQ---ISDSVHYTEGALVVRVLDV 1985
+S+ F ID NTGV+ LDFE Y L ++ + D + + +++
Sbjct: 3232 TVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGT 3291
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSV--LTLSATDLESNENISYRILSSS--KEFSIDPK 2041
N+ P F Y + E+ P G V + S DL ++ + Y I +S K F I+ K
Sbjct: 3292 NEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKK 3351
Query: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGGN---PDLRALTLVEIGIEDMNNYAPEFTVKS 2098
G I+ +S +L + V A + G+ D+ +T V + + D N+ P FT+
Sbjct: 3352 TGQIY-VSGILDREKEERVSLKVLAKNFGSIRGADIDEVT-VNVTVLDAND-PPIFTLNI 3408
Query: 2099 YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQ 2158
Y++ +SE +G+ + S D D + Y I SGN F + Q
Sbjct: 3409 YSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSIN----------PQ 3458
Query: 2159 VGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH 2218
G + + LDRE + L +LA DSG P + +A + + + D+NDN P +
Sbjct: 3459 TGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT--VSEGE 3516
Query: 2219 VKESTPLGSHITVVSANDRD-TGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK 2277
V E+ G+ + + + D D + Y ++S ++ GVL + +D E+
Sbjct: 3517 VMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ 3576
Query: 2278 MTKFTLTVQASDAEKKHF-SFAVVFVSVLDDNDHAPQ 2313
+ F L+V D+ S V ++V+D ND+ Q
Sbjct: 3577 IADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQ 3613
Score = 677 bits (1746), Expect = 0.0
Identities = 636/2236 (28%), Positives = 1018/2236 (45%), Gaps = 216/2236 (9%)
Query: 390 VPEDSPIGT-----VKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 444
VPED+ +G+ A ++ I YR+ D G F + P G I R+PLD E +
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVREPLDFEAR 316
Query: 445 PVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPA-----FLRTSDEIRISQTTPPGTA 498
LTVQA P+ + E I ++DVNDN P F TS + + GT
Sbjct: 317 RQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTV 376
Query: 499 LYLARAEDRDS-GRNGLIRYSI-ASPQPGVFAIDRA----LGVLFLNGSLGAGEQRELTL 552
+ L D DS NG I I + F + + L ++ + +L L
Sbjct: 377 VALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNL 436
Query: 553 TLRAEDQ-----GVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLSPMTQM 604
T+ D G QA V ++VI + +H P F VY+V +SE P + +
Sbjct: 437 TVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPP--VFSQQVYRVNLSEEAPPGSYV 494
Query: 605 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664
A G + LRYS+ F I ++G + + +
Sbjct: 495 SGISATD-GDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNIS 553
Query: 665 IPEDGFLQNVS-TTVIVRVWDENDNSPTFL----HDVLFLKVEESPVPQGVIGKITAIDM 719
+ G VS ++V + D ND P F +DV VE +P ++ + A D
Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSV--VENAPTGTELL-MLRATDG 610
Query: 720 DSGKNGQLLYFLL---SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D G NG + + L +D + F+++P +G TI
Sbjct: 611 DLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTIS------------------------- 645
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+LDRE + + + VL TD GSPP+++ + VS+ DINDN
Sbjct: 646 -------------------SLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNS 686
Query: 837 P-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDA 895
P F+P + + E +P +TTV A DPD G N V YS+S+ D S F+++A
Sbjct: 687 PVFYP-----VQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRS-RFQVNA 740
Query: 896 NNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955
+G I T L + + +Y++ ++ATD G QA+V I V+ + SQ
Sbjct: 741 QSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSF 800
Query: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
++ EN+ + + +S N + + I D+ G F I+ TG L + +D E
Sbjct: 801 VVFENVALGYHVGSVSAS---TMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDRE 857
Query: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVY 1075
S Y +V+ + +++ ++I V+D ND+SP F + ++V EN G ++
Sbjct: 858 EQSFYQLKVVASGG----TVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIF 913
Query: 1076 VFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTAS 1135
A D D +N + Y ++ NP N F I+ GT+ + LD + + + + AS
Sbjct: 914 QAKAVDPDEG-VNGMVLYSLK-QNP-KNLFAINEKNGTISLLGPLDVHA-GSYQIEILAS 969
Query: 1136 DQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDE 1193
D V + S+ + + DVND++P F +S+ + E V S + A D D
Sbjct: 970 DMGV---PQLSSSVILTVYVHDVNDNSPVFDQLSY-EVTLSESEPVNSRFFKVQASDKDS 1025
Query: 1194 GRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQ 1253
G NG++ Y+I GN F + G L LD E++ +++L V+A D LS++
Sbjct: 1026 GANGEIAYTIAEGNTGDAFGI-FPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATV 1084
Query: 1254 TLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS 1313
+TV + DVND P+F Y +E Q G FV +V A+D+D G N ++++ S
Sbjct: 1085 NVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRY------S 1138
Query: 1314 FEL----FEINSDTGEVVTTTILDREI------QEVFTLRVLVRDGGFPS-LSSTTTILC 1362
FE+ FE+++ +GE+ T DRE VF+ V+ D G P L T+
Sbjct: 1139 FEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198
Query: 1363 TVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECF 1421
++D ND+AP+F+ Y + E+ V V ASD+D GNN + Y II GN + F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258
Query: 1422 TINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481
I+ SG+++ LD E ++LVI D G P +S L + +LD ND++PSFP
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS 1318
Query: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS-GAFTIDPMSGTLKTSNTL 1540
V E+ +G +V ++A D D G N Y +T + G F+I P +G++ + L
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKL 1378
Query: 1541 DREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS--PESPT 1598
D E +S + + A+D + RS+T+ + ++V D NDN P P D+F S P
Sbjct: 1379 DFETQSLYKLNITAKDQG-RPPRSSTMSVVIHVRDFNDNPPSFP--PGDIFKSIVENIPI 1435
Query: 1599 NQTTVIVRADDLDLGPNGTVVFSFAETQ---SMFSIDKYTGEIQFQQNPSSEYFPIW-LQ 1654
+ + V A D D NG + ++ + + F+ID+ G I E+ ++ L
Sbjct: 1436 GTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELT 1495
Query: 1655 LKVTDQGIPART------TTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
+K DQ +P T +LV + ++V + S + + G+ + T+ A
Sbjct: 1496 VKANDQAVPIETRRYALKNVTILVTDL-NDNVPMFISQNAL--AADPSAVIGSVLTTIMA 1552
Query: 1709 FAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG- 1766
PD ++Y I +G+ D + + SG L V + N LIV A G
Sbjct: 1553 ADPDEGANGEIEYEIINGDTDTFI-VDRYSGDLRVASALVPSQLIYN---LIVSATDLGP 1608
Query: 1767 --HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
++ ++ +++Q + P F Q Y + E + +VI + A G +EY
Sbjct: 1609 ERRKSTTELTIILQ--GLDGPVFTQPKYITILKEGEPIGTNVISIEAAS-PRGSEAPVEY 1665
Query: 1825 SILSGNQEE-----AFQIDALSGVITTKAILDYELTSSYSLI-VQATDK--GMPRLSNTT 1876
I+S EE F I +G+I T AILD E + L+ V A +K PR
Sbjct: 1666 YIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAE 1725
Query: 1877 VIKVQVTDINDNAPAFLPSEAVEIT--EDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNP 1934
V ++ + DINDN P F P++ +++T E+ G + ++ D D + + ++ S
Sbjct: 1726 V-EITLQDINDNPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGA 1783
Query: 1935 GTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQ 1994
F ID +G ++ + LD E ++Y LL++ D + ++ + + V DVND+ P FS+
Sbjct: 1784 DDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSR 1843
Query: 1995 DFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKE--FSIDPKNGTIFTISP 2050
Y +PE G V + ATD +S N I+Y + ++ F ++P G +F ++
Sbjct: 1844 PVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITG-VFNLTR 1902
Query: 2051 VLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110
+L + V A DGG V I D+N+ P F++ SY+ SL E+ VG
Sbjct: 1903 LLDYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVG 1960
Query: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
ST++ F+ D D N+ + YSI SG+S F V+ G L +L +LDR
Sbjct: 1961 STVLVFNVTDAD-DGINSQLTYSIASGDSLGQFTVDKN-----------GVLKVLKALDR 2008
Query: 2171 EASASHELVILASDSGCPPLS---STAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGS 2227
E+ + + LV+ D P S STA +SI +LDVNDNPP F S T++ E+TP+ +
Sbjct: 2009 ESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENTPIDT 2067
Query: 2228 HITVVSANDRDTGSHAEIIYNIIS--GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
+ A D D+G ++ I Y +++ GN+ F + G + L LD E+++ +TLTV
Sbjct: 2068 VVFKAQATDPDSGPNSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNYTLTV 2124
Query: 2286 QASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG 2344
A+D + S + V V VLD ND+ P F + + + EN + I + A D D G
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184
Query: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD 2404
G++ Y IV+ + F ID +TG I + LD E Y LTVQA D+G
Sbjct: 2185 TNGQVRYGIVN--------GNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGS 2236
Query: 2405 A--TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEK-NKDRQLIGRVEASDADAGIDGVIL 2461
T + V + + I++F P+F Y +PE + I +V A D D G + +
Sbjct: 2237 TPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLS 2296
Query: 2462 YSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFV 2521
Y L F N+ N + L++E ++ + S S + T +
Sbjct: 2297 YVL------FGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTI 2350
Query: 2522 NVSFSSEGTPLAVFAS 2537
NV + FAS
Sbjct: 2351 NVIVDDVNDNVPTFAS 2366
Score = 676 bits (1743), Expect = 0.0
Identities = 597/1992 (29%), Positives = 926/1992 (46%), Gaps = 187/1992 (9%)
Query: 628 SVDSAMFGIRPYTGWIYLRRQFDYES--TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDE 685
S A+F I TG +Y D ES + N V + P T V V V D
Sbjct: 75 SESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP------TYPTEVRVLVRDL 128
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTG 745
NDN+P F + + +E + TA D D G NG D + +++
Sbjct: 129 NDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGV-------DHRSYRI----- 176
Query: 746 PAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVA---LDREHR 802
+E F L GEG ++ V+ LDRE
Sbjct: 177 -----------------------IRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVT 213
Query: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
+++ V V D+G P R + V V+V DINDN P F V E V V
Sbjct: 214 PQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVF----GSSHYQAGVPEDAVVGSSV 269
Query: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
V A D DEG NA++ Y + +D F++D G I L ++ R Y ++V A D
Sbjct: 270 LQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMD 327
Query: 923 QGVPPLQGQAVVNIQVIPLSKGRAIMS-----QNIRHLIIPENLKPTKIMSLIKSSDHLQ 977
+GVP L G+A IQ++ ++ ++ R+ + EN + +++L+ +D
Sbjct: 328 RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS 387
Query: 978 QHYNGKLHFSIVADDKDGHFEIDSS-TGDLFLSK---ELDYETTSHYLFRVITTDH---- 1029
NG + I+ ++ HFE+ SS +L L K LD E Y V +D+
Sbjct: 388 PAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAP 447
Query: 1030 --SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ + SS L I V D NDH P F ++ +++ E P G+ V +A D D S L
Sbjct: 448 PGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGD-SGL 506
Query: 1088 NSRIQYYIESHNPGTNPFLIHPSFGTLVTVSR--LDRESIPTVILTVTASDQAVNVTDRR 1145
N+ ++Y I S N G F I G + T S LDRE ++L ++A DQ V+ +
Sbjct: 507 NANLRYSIVSGN-GLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVH---PK 562
Query: 1146 LRSLTAQIVILDVNDHNPTFISFPNAH---VKEDVTVGSLVHHITAHDPDEGRNGKVTYS 1202
+ + +LDVND P F S P + V E+ G+ + + A D D G NG V +S
Sbjct: 563 VSYAQLVVTLLDVNDEKPVF-SQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFS 621
Query: 1203 ILSG-NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLD 1261
+ + +F LD SG L+T LD E + + L VLA D G+P SS + V++LD
Sbjct: 622 LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Query: 1262 VNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINS 1321
+ND +PVF Y A +KEN+ G ++T V A D D G N +++ I G F++N+
Sbjct: 682 INDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAG-DRSRFQVNA 740
Query: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDI 1381
+G + T LDRE + + L+++ DGG + + TV D D+ P F +Y
Sbjct: 741 QSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSF 800
Query: 1382 EVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
V EN V +V AS MD +N + Y I G+ F IN+++G+L+T +DRE+
Sbjct: 801 VVFENVALGYHVGSVSASTMDLNSN--ISYLITTGDQKGMFAINQVTGQLTTANVIDREE 858
Query: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
S + L ++ S G +++++ V+ D ND+SP F +V E+ + G +
Sbjct: 859 QSFYQLKVVASG-GTVTGDTMVNITVK--DLNDNSPHFLQAIESVNVVENWQAGHSIFQA 915
Query: 1501 SAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ 1560
AVD DEG+NG Y L F I+ +GT+ LD A S + +A D +
Sbjct: 916 KAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS-YQIEILASDMGVP 974
Query: 1561 GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
S++VI+ VYV DVNDN PV +Q ++V LS P N V+A D D G NG + +
Sbjct: 975 -QLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAY 1033
Query: 1621 SFAE--TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGI-PARTTTGLLVIHME 1676
+ AE T F I G++ + E + L + +D+ + P T + VI +
Sbjct: 1034 TIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILED 1092
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCS 1735
D + F+ Y E AG+ + V A D ++YS D L +
Sbjct: 1093 VNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPD--FELHA 1150
Query: 1736 KSGQLTVKEPKFLDFEVRNE----VQLIVLAESSG----HRAYCKVAVLIQDENDNSPCF 1787
SG++T + +R V+A G + V V ++D NDN+P F
Sbjct: 1151 ISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKF 1210
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
+ YQA++SES V++V A+D+D G NGLI YSI+ GN+E F ID+ SG +T
Sbjct: 1211 LKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLI 1270
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA-VEITEDSLP 1906
LDYE T +YSL++QA D G L++T + + + D NDN P+F S V++ E+
Sbjct: 1271 GKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRI 1330
Query: 1907 GVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELL 1964
G +V+ V+ D D N+ +S +N GT F+I NTG + L K LDFE + Y+L
Sbjct: 1331 GELVSSVTATDSDSGDNADLYYSITGTNNHGT-FSISPNTGSIFLAKKLDFETQSLYKLN 1389
Query: 1965 IQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA--TDL 2019
I D + ++V+ V D NDNPP F ++ E+IP+G SV++++A D
Sbjct: 1390 ITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDA 1449
Query: 2020 ESNENISYRILSS---SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-DLR 2075
+ N +SY I+ F+ID GTI+T + + + + + V+A+D P + R
Sbjct: 1450 DINGQLSYTIIQQMPRGNHFTIDEVKGTIYT-NAEIDREFANLFELTVKANDQAVPIETR 1508
Query: 2076 --ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYS 2133
AL V I + D+N+ P F + L+ A++GS L T D D N +EY
Sbjct: 1509 RYALKNVTILVTDLNDNVPMF-ISQNALAADPSAVIGSVLTTIMAADPD-EGANGEIEYE 1566
Query: 2134 IISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSST 2193
II+G++ + F V+ + G L + +L + + L++ A+D G ST
Sbjct: 1567 IINGDT-DTFIVD----------RYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKST 1614
Query: 2194 AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS-- 2251
++I +L D P F+ Y T +KE P+G+++ + A GS A + Y I+S
Sbjct: 1615 TELTI-ILQGLDGPV-FTQPKYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYIVSVR 1671
Query: 2252 GNEK---GHFYLEENTGV--------------LYLIKPLDYEKMTKFTLTVQASDAEKKH 2294
EK F + +TG+ LYL+ EK T F T +A
Sbjct: 1672 CEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAE------ 1725
Query: 2295 FSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIV 2354
V +++ D ND+ P F V EN+ S I + A+D D G +TY+I+
Sbjct: 1726 -----VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTII 1780
Query: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVD 2414
S D F IDP +GD+ A + LD E +KY L V+A D G ++ + + +
Sbjct: 1781 SGA---------DDSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRINIT 1830
Query: 2415 IEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP--FFS 2472
+ +++ P F++ Y F +PE L+ + A+D D+G++G I Y + F
Sbjct: 1831 VSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFF 1890
Query: 2473 VNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPL 2532
+N G L R L Q + + +F + V+ N+ ++ P+
Sbjct: 1891 LNPITGVFNLTRLLDYEVQQY-------YILTVRAEDGGGQFTTIRVYFNILDVNDNPPI 1943
Query: 2533 AVFASSFSISLV 2544
+S+S SL+
Sbjct: 1944 -FSLNSYSTSLM 1954
Score = 651 bits (1679), Expect = 0.0
Identities = 657/2490 (26%), Positives = 1090/2490 (43%), Gaps = 232/2490 (9%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
E A + V+ASD D G G I YS+ G + F ID GQ+ + +D E
Sbjct: 1221 ESAANLTQVLRVSASDVDEGNNGLIHYSIIKG----NEERQFAIDSTSGQVTLIGKLDYE 1276
Query: 128 RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 187
PA Y L+++A D L++ + +D+ D NDN P F ST +
Sbjct: 1277 ATPA-YSLVIQAVDSGTIP----------LNSTCTLNIDILDENDNTPSFPKSTLFVDVL 1325
Query: 188 DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLY------SPEVEIL 241
+ + G + +V ATD DSG + Y + N F+I TG E + L
Sbjct: 1326 ENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSL 1385
Query: 242 SAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKV 301
+N +A + + ++ H + D + + + + +
Sbjct: 1386 YKLNITAKDQGRPPRSSTMSVVIHVRDFN-DNPPSFPPGDIFKSIVENIPIGTSVISVTA 1444
Query: 302 QDEAASADGEAAARYVANLAK----ILGE--GIIYLTLPLSHLESTTLSLMVSAQDGGG- 354
D A +G+ + + + + + E G IY + + L V A D
Sbjct: 1445 HDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVP 1504
Query: 355 -------------LTAVINADVTIHIFQTTLA--PAEFERPKYTFLVYEDVPEDSPIGTV 399
L +N +V + I Q LA P+ T ++ D P++ G +
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAAD-PDEGANGEI 1563
Query: 400 KAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAP 459
+ Y I +GD F + G +R L ++ LG
Sbjct: 1564 E------------YEIINGDTD-TFIVDRYSGDLRVASALVPSQLIYNLIVSATDLGPER 1610
Query: 460 ACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI 519
S+TE+ I + ++ P F + + + P GT + A G + Y I
Sbjct: 1611 RKSTTELTIILQGLDG--PVFTQPKYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYI 1667
Query: 520 ASPQ------PGVFAIDRALGVLFLNGSLGAGEQRELTLT--LRAEDQGVHPQAALLVLT 571
S + +F I R G++ L + L L E P+ +
Sbjct: 1668 VSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVE 1727
Query: 572 VVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS 631
+ ++ +P F + + V E++ ++++Q A + A + + Y++ D
Sbjct: 1728 ITLQDINDNPP-VFPTDMLDLTVEENIGDGSKIMQLTAMD-ADEGANALVTYTIISGADD 1785
Query: 632 AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 691
+ F I P +G + R+ D E Y+ V A +DG LQ+ + + V D ND++P
Sbjct: 1786 S-FRIDPESGDLIATRRLDRERRSKYSLLVRA---DDG-LQSSDMRINITVSDVNDHTPK 1840
Query: 692 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGPAGT 749
F V + E +P ++ I A D DSG NG++ Y + D + F +NP TG
Sbjct: 1841 FSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITG---- 1896
Query: 750 IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTV 809
F L L LD E + ++ +TV
Sbjct: 1897 --------------------------VFNLTRL--------------LDYEVQQYYILTV 1916
Query: 810 LVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 869
D G + T+ VY ++ D+NDN P F ++E PV V D
Sbjct: 1917 RAEDGGG--QFTTIRVYFNILDVNDNPPIFSL----NSYSTSLMENLPVGSTVLVFNVTD 1970
Query: 870 PDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD-QGVPPL 928
D+G N+++TYS++S DS F +D NG ++ L + + Y + V D +P
Sbjct: 1971 ADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPAS 2029
Query: 929 QGQAVVNIQVIPLSKGR---AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLH 985
+ + + +I L +S + + IPEN ++ +++D N +
Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTFLSPKLTY--IPENTPIDTVVFKAQATDP-DSGPNSYIE 2086
Query: 986 FSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDV 1045
++++ + F I + G++ L+ ELD E S+Y V+ TD + SLSS+ + + V
Sbjct: 2087 YTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQP-SLSSSTEVVVMV 2144
Query: 1046 EDQNDHSPSFQDELIVISVEENVPIGT-LVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP 1104
D ND++P F L + + EN GT ++ VF A D+G+ N +++Y I + N
Sbjct: 2145 LDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGT--NGQVRYGIVNGNTNQE- 2201
Query: 1105 FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT 1164
F I G + LDRE PT LTV A+D+ + R + T IV+LD+ND P
Sbjct: 2202 FRIDSVTGAITVAKPLDREKTPTYHLTVQATDRG---STPRTDTSTVSIVLLDINDFVPV 2258
Query: 1165 FISFP-NAHVKEDV-TVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLT 1222
F P + +V E++ T+ + + A D D G N K++Y + GNE+ F L +SG L
Sbjct: 2259 FELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGELG 2317
Query: 1223 TTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQ 1282
T LD E K + +L + A D G+PAL+ + T+ V V DVND P F Y ++ E+
Sbjct: 2318 VTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDA 2377
Query: 1283 NPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTL 1342
G V V A D D+ N+ ++ I+ G S F IN TG+++T+ +LDRE ++ +TL
Sbjct: 2378 PTGTDVLLVNASDADASKNAVIR--IIGGNS--QFTINPSTGQIITSALLDRETKDNYTL 2433
Query: 1343 RVLVRDGGFPS-LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDM 1400
V+ D G P LSS+T++L TV D ND+ P F Y + P V+ V +D
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDA 2493
Query: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSS 1460
D G N + Y + G E F I+ + G + L+ S T + D G P++
Sbjct: 2494 DIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLNGA--SEVTFSVHVKDGGSFPKTD 2550
Query: 1461 VIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQ--TEYFLT 1518
+ VR ++ D P E+ V ++V ++ L G+ + Y +
Sbjct: 2551 STTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITG----SSLRGEPMSYYIAS 2605
Query: 1519 DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578
F ID ++G + S LD E ++ ARD S + + V DVND
Sbjct: 2606 GNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKL-DITVLDVND 2664
Query: 1579 NDPVLEQNPF-DVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYT 1635
N P+ +++PF L SP TV A D D GPNG + + ++ FSI+ T
Sbjct: 2665 NAPIFKEDPFISEILENLSPRKILTV--SAMDKDSGPNGQLDYEIVNGNMENSFSINHAT 2722
Query: 1636 GEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVT 1694
GEI+ + E + L +K +D+G P+++T+ ++I++ E+ ++ V
Sbjct: 2723 GEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Query: 1695 ENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
EN G ++ V D I +YSI + ++ +G + + P L+ E
Sbjct: 2783 ENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTIN--PSTGDIVISRP--LNREDT 2838
Query: 1754 NEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATD 1813
+ ++ V A SG V + + D NDN+P F ++ Y E + V QVFATD
Sbjct: 2839 DRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATD 2898
Query: 1814 LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYS--------LIVQAT 1865
D G NG + Y I S Q E F+I+A +G I K IL Y+ + +S IV ++
Sbjct: 2899 PDEGSNGQVFYFIKS--QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSS 2956
Query: 1866 DKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPG---VIVTHVSVHDVDLN 1921
D+G P L + T + + + D NDNAP FL S+ +T++ G + VT + D LN
Sbjct: 2957 DRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLN 3016
Query: 1922 SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGAL 1978
S + + +++ G KF +D +TG + + +L + + + + D + ++ +
Sbjct: 3017 SEVEYFISNDNHLG-KFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATV 3075
Query: 1979 VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE- 2035
+ V + N + P FSQ T+PES +G V T+SA D ++ N I Y I S ++E
Sbjct: 3076 HITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEG 3135
Query: 2036 -FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEF 2094
F+I+ G I T++ L + + + A DGG V + + D+N+ +P F
Sbjct: 3136 IFAINSSTG-ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF 3194
Query: 2095 TVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEY 2154
Y ++ E+A G+T++ + D D + N + Y++ S +S + F ++
Sbjct: 3195 LSDDYFPTVLENAPSGTTVIHLNATDAD-SGTNAVIAYTVQSSDS-DLFVIDPN------ 3246
Query: 2155 PYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS 2214
G + LD E S+ L + A + S A ++IQ+ N+ P F S
Sbjct: 3247 ----TGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKL 3302
Query: 2215 YHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLD 2274
Y+ + E+ P G+ + V A+DRD G+ E+ Y I + K F + + TG +Y+ LD
Sbjct: 3303 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILD 3362
Query: 2275 YEKMTKFTLTVQASD---AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
EK + +L V A + V V+VLD ND P F + +S + E +PI +
Sbjct: 3363 REKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGT 3421
Query: 2332 TICSINALDFDAGP-YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG 2390
+ ++A D D+ P + +Y I G ++ F I+P TG I LD E
Sbjct: 3422 HVTFVSAFDSDSIPSWSRFSYFI--------GSGNENGAFSINPQTGQITVTAELDRETL 3473
Query: 2391 NKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Y L+V A D G AT S + V +E I++ P+ T + + E + L+ ++
Sbjct: 3474 PIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQ 3531
Query: 2449 ASDAD----AGIDGVILYSLGTSSPFFSVN 2474
++D D G L S G ++ +FS++
Sbjct: 3532 STDPDLPPNQGPFTYYLLSTGPATSYFSLS 3561
Score = 625 bits (1613), Expect = e-178
Identities = 607/2236 (27%), Positives = 1002/2236 (44%), Gaps = 210/2236 (9%)
Query: 380 PKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL 439
P+ F V E+ P + +GT++ R YR+S F+I+ G + T +
Sbjct: 45 PRQVFQVLEEQPPGTLVGTIQTRPGFT------YRLSESH--ALFAINSSTGALYTTSTI 96
Query: 440 DHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL 499
D E+ P V+ + L SAP TEV + V D+NDN P F S + + + G +
Sbjct: 97 DRESLPSDVINLVV-LSSAPTYP-TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQV 154
Query: 500 YLARAEDRDSGRNGLIRYS---IASPQPGVFAIDRALGV----LFLNGSLGAGEQRELT- 551
L A D D G NG+ S I + G F +D L FL+ G RE+T
Sbjct: 155 ILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTP 214
Query: 552 ---LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 608
L + ED+G + L + V ++ +P F YQ V E + +LQ
Sbjct: 215 QYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPP-VFGSSHYQAGVPEDAVVGSSVLQVA 273
Query: 609 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 668
A + + +RY L+ + F + P TG I +R D+E+ + Y+ V A D
Sbjct: 274 AAD-ADEGTNADIRYRLQD--EGTPFQMDPETGLITVREPLDFEARRQYSLTVQAM---D 327
Query: 669 GFLQNVS--TTVIVRVWDENDNSPT-----FLHDVLFLKVEESPVPQGVIGKITAIDMDS 721
+ +++ ++++ D NDN P F + V+E+ V+ +T D DS
Sbjct: 328 RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS 387
Query: 722 -GKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
NG + +L + + + +I A
Sbjct: 388 PAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVAS----------------------- 424
Query: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDR-GSPP------RNATMAVYVSVTDIN 833
ALDRE + +TV V+D G+PP R++ ++ + V DIN
Sbjct: 425 ---------------ALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIN 469
Query: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
D+ P F Q + V + E P V+ + A D D G NA + YS+ S + F I
Sbjct: 470 DHPPVFSQ----QVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 894 DANNGEIRTTTI--LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQN 951
++G + T + L + +++ A DQGV P A + + ++ ++ + + SQ
Sbjct: 526 SEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQP 585
Query: 952 IRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH-FEIDSSTGDLFLSK 1010
+ + PT L+ + NG + FS+ + D F +D +G L
Sbjct: 586 EGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTIS 645
Query: 1011 ELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPI 1070
LD E + Y V+ TD + SS +++ + D ND+SP F ++EN P
Sbjct: 646 SLDREEQAFYSLLVLATDLG-SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPG 704
Query: 1071 GTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVIL 1130
G+ + +A D D N ++Y I + + + F ++ G + T LDRE L
Sbjct: 705 GSYITTVSATDPDLG-TNGTVKYSISAGD--RSRFQVNAQSGVISTRMALDREEKTAYQL 761
Query: 1131 TVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVK-EDVTVGSLVHHITAH 1189
+ A+D N+ +T I +LD D+ P F + V E+V +G V ++A
Sbjct: 762 QIVATDGG-NLQSPNQAIVT--ITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSAS 818
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
D N ++Y I +G++ F +++ +G LTT +D E ++ + L V+A GT +
Sbjct: 819 TMD--LNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-SGGT--V 873
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
+ + +TV D+ND +P F Q + +V EN G + + +A+D D GVN + + +
Sbjct: 874 TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK 933
Query: 1310 PGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND 1369
LF IN G + LD + + +L D G P LSS+ + V D ND
Sbjct: 934 QNPK-NLFAINEKNGTISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVND 991
Query: 1370 HAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG 1428
++P F SY++ + E++ + V ASD D+G N + Y I +GNT + F I G
Sbjct: 992 NSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DG 1050
Query: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR 1488
+L LDRE + L+++ SD P S+ +++ V + D ND+ P F + Y
Sbjct: 1051 QLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFE 1110
Query: 1489 EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548
E+ G+ V +SAVDKD G NG+ Y + F + +SG + ++ DRE+ +
Sbjct: 1111 EEQRAGSFVGKVSAVDKDFGPNGEVRYSF-EMVQPDFELHAISGEITNTHQFDRESLMRR 1169
Query: 1549 ------TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
+F+ +A D I + VY+ D+NDN P ++ + +S ES N T
Sbjct: 1170 RGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATIS-ESAANLTQ 1228
Query: 1603 VI-VRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT 1658
V+ V A D+D G NG + +S + F+ID +G++ E P + L ++
Sbjct: 1229 VLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAV 1288
Query: 1659 DQG-IPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS 1717
D G IP +T L + ++ D SF V EN G + +V A DS ++
Sbjct: 1289 DSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNA 1348
Query: 1718 -MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKV 1773
+ YSI N G S+ +G + + K LDFE ++ +L + A+ G + V
Sbjct: 1349 DLYYSITGTNNHGTFSISPNTGSIFL--AKKLDFETQSLYKLNITAKDQGRPPRSSTMSV 1406
Query: 1774 AVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS----G 1829
+ ++D NDN P F S+ E+ VI V A D D+ +NG + Y+I+ G
Sbjct: 1407 VIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRG 1466
Query: 1830 NQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP------RLSNTTVIKVQVT 1883
N F ID + G I T A +D E + + L V+A D+ +P L N T++ VT
Sbjct: 1467 NH---FTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTIL---VT 1520
Query: 1884 DINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQN 1943
D+NDN P F+ A+ ++ G ++T + D D + + + F +D+
Sbjct: 1521 DLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRY 1580
Query: 1944 TGVVVLVKTLDFEEMTEYELLIQISD-----SVHYTEGALVVRVLDVNDNPPVFSQDFYQ 1998
+G + + L ++ Y L++ +D TE ++++ LD PVF+Q Y
Sbjct: 1581 SGDLRVASALVPSQLI-YNLIVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYI 1635
Query: 1999 VTVPESIPVGYSVLTLSATDLESNE-NISYRILSSSKE-------FSIDPKNGTIFTISP 2050
+ E P+G +V+++ A +E + Y I+S E F+I G I T +
Sbjct: 1636 TILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAA- 1694
Query: 2051 VLLLD------TISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLS 2104
+LD + +E S RA VEI ++D+N+ P F +L++
Sbjct: 1695 --ILDREQGACLYLVDVYAIEKSTAFPRTQRA--EVEITLQDINDNPPVFPTDMLDLTVE 1750
Query: 2105 EDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVL 2164
E+ GS ++ + +D D N V Y+IISG + ++F ++ + G L+
Sbjct: 1751 ENIGDGSKIMQLTAMDAD-EGANALVTYTIISG-ADDSFRID----------PESGDLIA 1798
Query: 2165 LHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224
LDRE + + L++ A D SS I+I V DVND+ P FS Y + E T
Sbjct: 1799 TRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTI 1855
Query: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLT 2284
GS + + A D D+G + EI Y + +E G F+L TGV L + LDYE + LT
Sbjct: 1856 PGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILT 1915
Query: 2285 VQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG 2344
V+A D + F+ V+ ++LD ND+ P F +S+S + ENLP+ ST+ N D D G
Sbjct: 1916 VRAEDGGGQ-FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDG 1974
Query: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--- 2401
+LTYSI S L F +D G + + LD E+ + Y L VQ D
Sbjct: 1975 INSQLTYSIASGDSLGQ--------FTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQ 2025
Query: 2402 --KGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGV 2459
T++ V + + +++ P F + + +PE ++ + +A+D D+G +
Sbjct: 2026 IPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSY 2084
Query: 2460 ILYS-LGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKED--TLEMKIIAHSPKSDSKFAS 2516
I Y+ L FS+ +G + L +L++E+ + ++A S +S
Sbjct: 2085 IEYTLLNPLGNKFSIGTIDGEVRL-------TGELDREEVSNYTLTVVATDKGQPSLSSS 2137
Query: 2517 CTVFVNVSFSSEGTPL 2532
V V V ++ P+
Sbjct: 2138 TEVVVMVLDINDNNPI 2153
Score = 201 bits (510), Expect = 1e-50
Identities = 257/1059 (24%), Positives = 453/1059 (42%), Gaps = 140/1059 (13%)
Query: 69 ENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER 128
EN P K V+A D DSG G ++Y + +G + +F I+ G+I + +DRE+
Sbjct: 2680 ENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNME----NSFSINHATGEIRSVRPLDREK 2735
Query: 129 DPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRV--DLEDVNDNHPVFNPSTYVTSI 186
+ Y L +++ D KG S V+V ++ D NDN P F+ + +
Sbjct: 2736 -VSHYVLTIKSSD------------KGSPSQSTSVKVMINILDENDNAPRFS-QIFSAHV 2781
Query: 187 SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------------- 232
+ + G + V +D+D GI Y ++ ++ FTI+ +TG
Sbjct: 2782 PENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNREDTD 2839
Query: 233 -------------LYSPEVEI-LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEK 278
S +V I ++ +N +A + S + P L A +
Sbjct: 2840 RYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDP 2899
Query: 279 KFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHL 338
E S G F + Y ++ + GE + + + G S++
Sbjct: 2900 D-EGSNGQVFYFI-KSQSEYFRIN----ATTGEIFNKQILKYQNVTG---------FSNV 2944
Query: 339 ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT 398
S +V++ D G + + VTI+I + +F + KY V ++V + +
Sbjct: 2945 NINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004
Query: 399 VKAREP----LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 454
V A + LNS + Y IS+ + GKF + G I L + +TV A+
Sbjct: 3005 VTAIDDKDFGLNSE--VEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAK 3062
Query: 455 -LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
G+ P S V+ITV + N + P F ++ I ++ G+ + A DRD+ NG
Sbjct: 3063 DKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNG 3122
Query: 514 LIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 572
LI+YSI+S + G+FAI+ + G+L L +L ++ +T+ A D G + +TV
Sbjct: 3123 LIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTV 3182
Query: 573 -VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS 631
VI+ ++SP + + Y V E+ T ++ A A + Y+++ S DS
Sbjct: 3183 NVIDVNDNSPVFLSDD--YFPTVLENAPSGTTVIHLNATDADSGTNAV-IAYTVQSS-DS 3238
Query: 632 AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW-IPEDGFLQNVSTTVIVRVWDENDNSP 690
+F I P TG I + D+E+ Q+Y+ V A+ +P++ TV +++ N+ P
Sbjct: 3239 DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCS--FATVNIQLKGTNEYVP 3296
Query: 691 TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGPAG 748
F+ + + ++ E+ ++G++ A D D G +G++ Y + + K F++N TG
Sbjct: 3297 RFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQ-- 3354
Query: 749 TIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMT 808
IYV SG LDRE +
Sbjct: 3355 -IYV----------SGI-------------------------------LDREKEERVSLK 3372
Query: 809 VLVTDRGSPPRNATM---AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 865
VL + GS R A + V V+V D ND P V++ EG P+ VT V
Sbjct: 3373 VLAKNFGSI-RGADIDEVTVNVTVLDAND-----PPIFTLNIYSVQISEGVPIGTHVTFV 3426
Query: 866 FAKDPDEGNN-AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
A D D + + +Y + S + + F I+ G+I T L + P Y +SV+A D G
Sbjct: 3427 SAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSG 3486
Query: 925 VPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL 984
P G A + + + ++ +++ + ++ EN +P ++ ++S+D G
Sbjct: 3487 TPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPGTLVMTLQSTDPDLPPNQGPF 3544
Query: 985 HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSID 1044
+ +++ + S+ G L ++E+D E + + V+T D S +SST + I
Sbjct: 3545 TYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKD-SGVPQMSSTGTVHIT 3603
Query: 1045 VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDD 1083
V DQND+ + I ++ N+ G ++ +D D
Sbjct: 3604 VIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD 3642
Score = 122 bits (306), Expect = 5e-27
Identities = 146/589 (24%), Positives = 245/589 (41%), Gaps = 77/589 (13%)
Query: 25 STDACVYEVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEENAKPVKETEVTASDA 84
S+ A V+ + N SQ + PE+ G+IV V+A D
Sbjct: 3070 SSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIV-------------RTVSARDR 3116
Query: 85 DSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDE 144
D+ + G I+YS+ G F I+ G + +++ +D E +++ + A DG
Sbjct: 3117 DAAMNGLIKYSISSG----NEEGIFAINSSTGILTLAKALDYELCQK-HEMTISAIDGGW 3171
Query: 145 QRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 204
T V V++ DVNDN PVF Y ++ + GT +I++ ATD
Sbjct: 3172 VART----------GYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDA 3221
Query: 205 DSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLR 264
DSG +AY + + S LF ID TG+ + + + D E S + +
Sbjct: 3222 DSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFL--------DFETKQSYHLTVKAFN 3272
Query: 265 HFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASA---------------D 309
+ + + + + RF + L+Y ++ + A D
Sbjct: 3273 VPDEERCSFATVNIQLKGTNEYVPRFVSK--LYYFEISEAAPKGTIVGEVFASDRDLGTD 3330
Query: 310 GEAAARYVANLAKILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVT 364
GE N K + G IY++ L + +SL V A++ G + +VT
Sbjct: 3331 GEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVT 3390
Query: 365 IHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGT----VKA--REPLNSSEPIFYRISS 417
+++ T+ A + P +T +Y + E PIGT V A + + S Y I S
Sbjct: 3391 VNV---TVLDAN-DPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446
Query: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 476
G+ G FSI+P+ G I LD ET P+ L+V A G+ A S + +T+ D+NDN
Sbjct: 3447 GNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDN 3506
Query: 477 HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRN-GLIRYSIAS--PQPGVFAIDRAL 533
P + T E + + PGT + ++ D D N G Y + S P F++ A
Sbjct: 3507 GP--MLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTA- 3563
Query: 534 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPS 582
GVL + + + L++ +D GV ++ + + + + +PS
Sbjct: 3564 GVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPS 3612
Score = 84.7 bits (208), Expect = 1e-15
Identities = 59/179 (32%), Positives = 87/179 (48%), Gaps = 29/179 (16%)
Query: 54 PETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 113
PE +VF++Q A+D DSG +IEY+L + F I
Sbjct: 2060 PENTPIDTVVFKAQ-------------ATDPDSGPNSYIEYTLLNPL-----GNKFSIGT 2101
Query: 114 HDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDN 173
DG++ ++ ++DRE + + Y L V A D + LS+ V V + D+NDN
Sbjct: 2102 IDGEVRLTGELDRE-EVSNYTLTVVATDKGQP----------SLSSSTEVVVMVLDINDN 2150
Query: 174 HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232
+P+F + Y I++ T GT+II V A D D G G V Y ++ GN + F IDS TG
Sbjct: 2151 NPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTG 2209
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 738 bits (1904), Expect = 0.0
Identities = 689/2425 (28%), Positives = 1096/2425 (45%), Gaps = 213/2425 (8%)
Query: 161 AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 220
A V++ L + NDN P+F+ Y S+ + GT ++ VLATD D+G +G V+Y +
Sbjct: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SD 501
Query: 221 VSSLFTIDSTTGLYSP----EVEILSAVNFS------ADKEVMNSLEM-FLPLLRHFKKV 269
F++D TGL + E++ + +E + + L + +
Sbjct: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
Query: 270 ERDEEA-AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGI 328
++D A ++ E S +R + Q + A Y +++ G G+
Sbjct: 562 QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF-DISLYEGYGV 620
Query: 329 IYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386
I ++ PL + + + + L V A D G VTI +F P F +P Y V
Sbjct: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
Query: 387 YEDVPEDSPIGTVKAREPLNS----SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE 442
E++ + + + A + S E I Y + +F I+ R G I T LD E
Sbjct: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDRE 737
Query: 443 TQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL 499
T+ +L V+A G T VNIT++D+NDNHP + I + + TPP + +
Sbjct: 738 TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797
Query: 500 YLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE-----QRELT--L 552
A D D G NG + YSI P ++++ G + ++ E + EL +
Sbjct: 798 TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKI 856
Query: 553 TLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 609
+ D G P A TV +++ ++ P TF++L + EV E + + Q A
Sbjct: 857 VVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVVA 914
Query: 610 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 669
L + + Y + + F I +G + + D E Y RV A + G
Sbjct: 915 IDLD-EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDAG 971
Query: 670 FLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 728
ST T+ + V D ND +PTF V + V E + + + D D G N +L
Sbjct: 972 TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
Query: 729 YFLLS---DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCE 785
YF+ DGKF + + D V++++
Sbjct: 1032 YFITGGNVDGKFS--------------VGYRDA-------------------VVRTV--- 1055
Query: 786 LGEGELINWVALDREHRGHHEMTVLVTDRGSPPRN--ATMAVYVSVTDINDNRPFFPQCL 843
V LDRE + + + D G + T V+V+V D+NDNRP F Q
Sbjct: 1056 ---------VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
Query: 844 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI-RT 902
+ + EG + L T D DEG V Y + + ++F+I +NG + R
Sbjct: 1107 YEASVPEDIPEGHSILQLKAT----DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
Query: 903 TTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQN-IRHLIIPENL 961
L + S+ + V A + + P++ V + V ++ + +Q L + E
Sbjct: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETA 1222
Query: 962 KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYL 1021
+ +++++D G +++ I++ +G FEID STG + LDYET + Y+
Sbjct: 1223 GIGTSVIVVQATDR-DSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYM 1280
Query: 1022 FRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGT-LVYVFNAK 1080
V TD + + + I + ++ D + F + ++ EN+ +GT +V V
Sbjct: 1281 MNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339
Query: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
D+ + + R Y + F I G + +DRE LTV A D
Sbjct: 1340 IDNLNQITYRFNAYTSTQAKAL--FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK 1397
Query: 1141 VTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGK 1198
V ++ I +LD ND++P F S + ED VG V + A DPD G NG+
Sbjct: 1398 VDS----TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
Query: 1199 VTYSILSGNENMTFML---DESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTL 1255
V +S+ SGN F + ++S G + PLD E +IL V+A D GTP L
Sbjct: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
Query: 1256 TVTVLDVNDEAPVFKQHL-YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASF 1314
VT+LD+ND PV + Y SV EN G V +V A DRD G+NS L + I G
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Query: 1315 ELFEINSDTGEVVTTTIL-DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPE 1373
F ++ +GE+ T DRE Q + L V D G P+LS+TT + T+ DEND+AP
Sbjct: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
Query: 1374 FIVSSYDIEVLENQEPEVVYTVL----ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGE 1429
F Y EVL ++ P+ + T L A D+D G N V Y I+ GN F I+ G
Sbjct: 1634 FQQPHY--EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV 1691
Query: 1430 LSTTRALDRE-QISNFTLVILCSD---LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
++ + LD E +TL++ +D + +S + V V D ND+ P+FP Y
Sbjct: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNT--LDR 1542
+ + G V A D+D G NGQ EY + D + G F I P+ G L+ LDR
Sbjct: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
Query: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
E + + + ARD + S+T+++ + V D+NDNDPVL P ++ +S SP +
Sbjct: 1812 ETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
Query: 1603 VIVRADDLDLGPNGTVVFSFA--ETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ 1660
V A D D G N + F+ + F I+ TG + + E P + +L ++ +
Sbjct: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY-KLTISVK 1929
Query: 1661 GIP-----ARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKA--FAPD 1712
P AR LL+I + E D F+ Y+ V EN AGT + + A D
Sbjct: 1930 DNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALD 1989
Query: 1713 SIQDSMKYSIFS--GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNE--VQLIVLAESSGH- 1767
+ QD + G + G+ + S +G +TV+ +D E + ++L++LAE G
Sbjct: 1990 ADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLL 2049
Query: 1768 RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSIL 1827
+ + + I D+NDN P F + + E+ V+QV ATD DSGLNG + Y I
Sbjct: 2050 NSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIE 2109
Query: 1828 SGNQEEAFQIDALSGVITT-KAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIN 1886
+G Q+ F I ++GVI A +D E SY L V ATD+G LS T ++ + + DIN
Sbjct: 2110 AGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
Query: 1887 DNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF----AKES------NPG 1935
D+ P FL P + V + E + PG ++ +++ D DLN + AK+ N
Sbjct: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQE 2228
Query: 1936 TKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--------SVHYTEGALVVRVLDVND 1987
FA++ NTG V++ ++ E + YE+ + + D SV L V VLDVND
Sbjct: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
Query: 1988 NPPVFSQ---DFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKN 2042
N P F +Y + E G +++ ++A D + N ++Y +L + ++
Sbjct: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLED 2348
Query: 2043 GTIFTISPVLLLD--TISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
+ + +D + F V ASD G+P A V + I D+N+ P F SY
Sbjct: 2349 SSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQ 2408
Query: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
++ ED VG+ ++T + D D + +EYS+ G S+ + T G
Sbjct: 2409 EAVFEDVPVGTIILTVTATDAD-SGNFALIEYSLGDGESKFAINPTT------------G 2455
Query: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSS----TAVISIQVLDVNDNPPNFSSLSYH 2216
+ +L SLDRE + L LA D+ S+ + + IQVLDVND P FS +
Sbjct: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
Query: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
T V E+ P G+ + + A D+D G + E+ Y++ G F+++ ++G++ +PL +
Sbjct: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--Q 2572
Query: 2277 KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI--VPENLPISSTI 2333
KF+LTV A+D E + ++ V V+D ND+ P F+ I + E +P+ S +
Sbjct: 2573 SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNV 2632
Query: 2334 CSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKY 2393
+ A D D G G + YS FL + D + F+IDP++G I Q LD E+ Y
Sbjct: 2633 YEVYATDKDEGLNGAVRYS-----FLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
Query: 2394 CLTVQAKDKGDAT---ASLVVWVDIEGIDEFEPIFTQ-----DQY-FFTLPEKNKDRQLI 2444
L + A D G + V +E ID+ EP+F + QY T+PE + L+
Sbjct: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLV 2747
Query: 2445 GRVE-ASDADAGIDGVILYSLGTSS 2468
G V A DAD G + ++ Y + +
Sbjct: 2748 GNVTGAVDADEGPNAIVYYFIAAGN 2772
Score = 650 bits (1678), Expect = 0.0
Identities = 613/2169 (28%), Positives = 986/2169 (45%), Gaps = 190/2169 (8%)
Query: 385 LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 444
L+ ED P S + + A++ N +P+ + +S + F++ P G + R+PLD ET+
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 445 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
TV+ + + +VNI V DVNDN P F +RI + TP GT +++ A
Sbjct: 99 SE--FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
Query: 505 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 563
D D G G + YS P FAID A G++ + L + LT+ A DQ P
Sbjct: 157 TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
Query: 564 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 616
+ L L ++I + ++ P F +L Y + E P +T + Q + P G
Sbjct: 216 LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
Query: 617 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 666
+ Y++ +++F + +G + L D E+ Y+ + P
Sbjct: 271 ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGTELNDDRTP 325
Query: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 723
D V+TT + V D NDN+P F + + E + V + I +D D G
Sbjct: 326 SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
Query: 724 NGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLF 783
N +L+ + F S +Q
Sbjct: 383 NSMFEVYLVGNNSHH----------------------------FIISPTSVQ-------- 406
Query: 784 CELGEGELINWVA--LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 841
G+ ++ VA LD E ++ L + P V +++ + NDNRP F Q
Sbjct: 407 ---GKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHVGYAKVKITLINENDNRPIFSQ 462
Query: 842 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIR 901
L ++ + E V V TV A D D G EV+Y S D D F +D + G I
Sbjct: 463 PL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS--DDPDRFSLDKDTGLIM 516
Query: 902 TTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENL 961
L Y+ + +++IA D G G+ V I V+ ++ ++ + EN
Sbjct: 517 LIARLDYELIQRFTLTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENE 574
Query: 962 KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG-HFEID--SSTGDLFLSKELDYETTS 1018
+ ++++D N ++ +SIV+ G +F+I G + +S+ LDYE S
Sbjct: 575 PSVTQLVRLRATDE-DSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
Query: 1019 H-YLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVF 1077
+ ++ + + N L+STV ++I+V D+ND+ P+F +SV EN+ G V
Sbjct: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFL 693
Query: 1078 NAKDDDGS--FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTAS 1135
NA D D S + I Y +E G+ F I+ G + T S LDRE+ IL V A
Sbjct: 694 NATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749
Query: 1136 DQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEG 1194
D V +++ T I +LD+ND++PT+ P ++ E S V + A DPD G
Sbjct: 750 DGGVG-HNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
Query: 1195 RNGKVTYSILSGNENMTFMLDESSGLLTTT-------CPLDYEMKTQHILTVLALDDGTP 1247
NG + YSI N+ + L+ ++G + TT P +E + + V D G P
Sbjct: 809 ENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
Query: 1248 AL--SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305
L +SS T+ V +LD+ND P F+ + A V E G + +V A+D D G+N +
Sbjct: 867 PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926
Query: 1306 FEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVE 1365
+ + G F INS +G VVTTT LDRE + LRV+ D G P+ SST+T+ V
Sbjct: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 986
Query: 1366 DENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTIN 1424
D ND P F + Y++ V E+ E V + +D D G N + Y I GN D F++
Sbjct: 987 DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
Query: 1425 EMSGELSTTRALDREQISNFTLVILCSDLGDPPR--SSVIHLQVRVLDANDHSPSFPTLY 1482
+ T LDRE + + L++ D G + + + V VLD ND+ P F
Sbjct: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
Query: 1483 YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTL-KTSNTL 1540
Y++SV ED G +L L A D DEG G+ Y L F I +G L + L
Sbjct: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
Query: 1541 DREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD-VFLSPESPTN 1599
DRE S H A + + RS+ +I VYV D+ND PV Q + + L +
Sbjct: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSRLGLRETAGIG 1225
Query: 1600 QTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEI----QFQQNPSSEYFPIWLQ 1654
+ ++V+A D D G G V + + + F ID+ TG I + Y +
Sbjct: 1226 TSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYM---MN 1282
Query: 1655 LKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS 1713
+ TDQ P + I + E D + FS+ Y+ + EN GT IV V+A++ D+
Sbjct: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
Query: 1714 I-QDSMKYSIFSGNE-DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHR--A 1769
+ Q + +++ ++ + + + + +G +TV+ +D E + L V+A+ G + +
Sbjct: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQ--GLVDREKGDFYTLTVVADDGGPKVDS 1400
Query: 1770 YCKVAVLIQDENDNSPCFE-QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828
KV + + DENDNSP F+ S S+ E V V A D D+G NG + +S+ S
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
Query: 1829 GNQEEAFQI----DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
GN AF+I D++ V + LD E Y L V A+D+G P +++V + D
Sbjct: 1461 GNIAGAFEIVTTNDSIGEVFVARP-LDREELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
Query: 1885 INDNAPAFLP--SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS-FAKESNPGTKFAID 1941
INDN P V + E+ G V V D D+ + S + E N F +D
Sbjct: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMD 1579
Query: 1942 QNTG-VVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLDVNDNPPVFSQDFY 1997
+ +G + D E + Y L+ + D T A + V ++D NDN P+F Q Y
Sbjct: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY 1639
Query: 1998 QVTVPES-IPVGYSVLTLSATDLESNEN--ISYRILSSS--KEFSIDPKNGTIFTISPVL 2052
+V + E + S++T+ A DL+ N ++Y I++ + F ID G I +
Sbjct: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
Query: 2053 LLDTISTTQFLVEASDGG---NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
+ +V A+D + L + T V + + D+N+ P F +
Sbjct: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
G + TF D D + N VEYSI+ G+ F + P + V + LD
Sbjct: 1760 GPRVWTFLAHDRD-SGPNGQVEYSIMDGDPLGEFVIS--------PVEGVLRVRKDVELD 1810
Query: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI 2229
RE A + L I A D G PPLSST ++ I+VLD+NDN P +L + + E++P+ S +
Sbjct: 1811 RETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
Query: 2230 TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289
V A+D D+G +A + +NI +GN + F++ TG++ + +PLD E++ ++ LT+ D
Sbjct: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
Query: 2290 ------AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN----AL 2339
++ + ++F+S D+ND+ P F S++ V EN P + + +N AL
Sbjct: 1931 NPENPRIARRDYDLLLIFLS--DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILAL 1988
Query: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQ--ILDYENGNKYC--L 2395
D D Y +TY + + LF I+ TG + + I+D E + L
Sbjct: 1989 DADQDIYAVVTYQL---------LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
Query: 2396 TVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAG 2455
+ A+D G ++ + + I ++ P F+ L E + +V A+D D+G
Sbjct: 2040 LLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG 2099
Query: 2456 IDGVILYSL 2464
++G ++Y +
Sbjct: 2100 LNGELVYRI 2108
Score = 629 bits (1622), Expect = e-179
Identities = 685/2525 (27%), Positives = 1084/2525 (42%), Gaps = 260/2525 (10%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
V A+D D+G +G + Y D P F +D G I + +D E + L +
Sbjct: 482 VLATDNDAGTFGEVSYFFSDD------PDRFSLDKDTGLIMLIARLDYELIQR-FTLTII 534
Query: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198
A+DG GG VR+++ DVNDN P F YV ++ + T+++
Sbjct: 535 ARDG------------GGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVR 582
Query: 199 VLATDQDSGIYGTVAYELIPGNV-SSLFTIDS------------------TTGLYSPEVE 239
+ ATD+DS + Y ++ + S F I + GL V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
Query: 240 ILSAVNFSADKEVMNSLEMFLPLLRH--FKKVERDEEAAEKKFEASRGWFMRFKGRRHLH 297
+ A N + V ++E+F F K E + F+
Sbjct: 643 AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
Query: 298 YLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGG---- 353
+ S +G R A G I T L + L+V A DGG
Sbjct: 703 EYGQESIIYSLEGSTQFRINAR------SGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 354 GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIF 412
T + ++T+ P + P Y LV E P DS + TV A +P L + +
Sbjct: 757 QKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPDLGENGTLV 814
Query: 413 YRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQLGSAPACS 462
Y I + +S++ G IRT P HE + +VV A S
Sbjct: 815 YSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATS 872
Query: 463 STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 522
S V + ++D+NDN P F + + P G ++Y A D D G NGL+ Y +
Sbjct: 873 SATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVG 932
Query: 523 QPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHS 580
P + F I+ + GV+ L E L + A D G +++ LT+ V++ + +
Sbjct: 933 MPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 581 PSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRP 638
P TF VY V VSE + ++ L + +G + L Y + F +
Sbjct: 993 P--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLN---AELSYFITGGNVDGKFSVGY 1047
Query: 639 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVL 697
+ D E+T Y + A ++ T TV V V D NDN P FL
Sbjct: 1048 RDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSY 1107
Query: 698 FLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
V E +P+G I ++ A D D G+ G++ Y +L G G + I +
Sbjct: 1108 EASVPED-IPEGHSILQLKATDADEGEFGRVWYRILH-----------GNHGNNFRIHVS 1155
Query: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
+G L G LDRE H + V +
Sbjct: 1156 NGL--------------------------LMRGPR----PLDRERNSSHVLIVEAYNHDL 1185
Query: 817 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 876
P +++ V V V DIND P F Q + + + E + V V A D D G+
Sbjct: 1186 GPMRSSVRVIVYVEDINDEAPVFTQ---QQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242
Query: 877 EVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNI 936
V Y + S + F+ID + G I T L Y+ + SY M+V ATDQ P QG V I
Sbjct: 1243 LVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
Query: 937 QVIPLSKGRAIMSQNIRHLIIPENLK-PTKIMSL-IKSSDHLQQ-HYNGKLHFSIVADDK 993
++ S I ENL T+I+ + S D+L Q Y + S A
Sbjct: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK-- 1359
Query: 994 DGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSP 1053
F+ID+ TG + + +D E Y V+ D + STV + I V D+ND+SP
Sbjct: 1360 -ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSP 1416
Query: 1054 SFQ-DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLI--HPS 1110
F +S+ E+ P+G V A D D N ++ + + S N ++ + S
Sbjct: 1417 RFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDS 1475
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP- 1169
G + LDRE + IL V ASD+ T R + Q+ ILD+ND NP I P
Sbjct: 1476 IGEVFVARPLDREELDHYILQVVASDRG---TPPRKKDHILQVTILDIND-NPPVIESPF 1531
Query: 1170 --NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG-LLTTTCP 1226
N V E+V G+ V + A D D G N ++Y I GN++M F +D SG + T P
Sbjct: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Query: 1227 LDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP-G 1285
D E ++ + L D+GTP LS++ + VT++D ND AP+F+Q YE + E +
Sbjct: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
Query: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
+ ++ALD D G N + + I+ G F I+ G + LD EI ++
Sbjct: 1652 TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIV 1711
Query: 1346 VRDGGFPSLS----STTTILCTVEDENDHAPEFIVSSYD--IEVLENQEPEVVYTVLASD 1399
P LS STTT+L V D ND+ P F Y+ EV E Q V+T LA D
Sbjct: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHD 1770
Query: 1400 MDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR--ALDREQISNFTLVILCSDLGDPP 1457
D+G N VEY I+DG+ F I+ + G L + LDRE I+ + L I D G PP
Sbjct: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL 1517
SS + + +RVLD ND+ P L ++ E++ V + V + A D D G N + + +
Sbjct: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
Query: 1518 T-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC--SIQGSRSTTVIIKVYVT 1574
T AF I+ +G + + LDRE ++ + +D + + +R ++ ++++
Sbjct: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
Query: 1575 DVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR----ADDLDLGPNGTVVFSFAETQS-MF 1629
D NDN P+ ++ + + SP ++ A D D V + QS +F
Sbjct: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
Query: 1630 SIDKYTGEIQFQQN---PSSEYFPIWLQLKVTDQGIPARTTTG-LLVIHMEGEDVKISFS 1685
I+ TG + + + P L+L + + I +T LL+ ++ D + +FS
Sbjct: 2011 DINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
Query: 1686 HHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKE 1744
+ ENC G S++ V A DS + + Y I +G +D L + +G + V
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTGVIRVGN 2129
Query: 1745 PKFLDFEVRNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801
+D E + +L V+A G V +LI D ND+ P F I SV ES
Sbjct: 2130 AT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
Query: 1802 YNAHVIQVFATDLDSGLNGLIEYSI-----------LSGNQEEAFQIDALSGVITTKAIL 1850
+ + A D D LN +EY I L NQE+AF ++ +G + K+ +
Sbjct: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
Query: 1851 DYELTSSYSLIVQATDKG--MPRLSNTTV---IKVQVTDINDNAPAFLPSEAV----EIT 1901
+ EL ++Y + + D +P S + + V V D+NDN P F P I
Sbjct: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
Query: 1902 EDSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
E + PG + V+ D D LN ++ PG D + G V+ +T+D+EE+
Sbjct: 2307 EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVH 2366
Query: 1960 EYELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
++ SD+ A + + ++D+NDN P+F Q YQ V E +PVG +LT++A
Sbjct: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
Query: 2017 TDLESNEN--ISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-- 2072
TD +S I Y + +F+I+P G I+ +S LD +++ A NP
Sbjct: 2427 TDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSS---LDREKKDHYILTALAKDNPGD 2483
Query: 2073 --DLRALTLVEIGIE--DMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128
R V++ I+ D+N+ P+F+ ++ S+ E+ G++++T D D N
Sbjct: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNG 2542
Query: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188
+ YS+ G FHV+ G + L ++ L ++A+D G P
Sbjct: 2543 ELTYSL-EGPGVEAFHVDM----------DSGLVTTQRPL--QSYEKFSLTVVATDGGEP 2589
Query: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHT--HVKESTPLGSHITVVSANDRDTGSHAEII 2246
PL T ++ ++V+DVNDN P F T H++E PL S++ V A D+D G + +
Sbjct: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
Query: 2247 YNII--SGNEKGHFYL-EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK--HFSFAVVF 2301
Y+ + +GN F++ + +G++ + LD E ++L + ASD + + + +
Sbjct: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Query: 2302 VSVLDDNDHAPQFMFSSFSC------IVPENLPISSTICSIN-ALDFDAGPYGELTYSIV 2354
V++ D +D+ P F+ VPE+ P + + ++ A+D D GP + Y I
Sbjct: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
Query: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG----------- 2403
+ + F + P G + + LD E + V+A
Sbjct: 2770 A--------GNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
Query: 2404 -DATASLV---VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGV 2459
D A L V V +E I++ P FT+ +Y + K + +V A DAD G + +
Sbjct: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
Query: 2460 ILYSL 2464
+ YS+
Sbjct: 2881 VFYSI 2885
Score = 629 bits (1621), Expect = e-179
Identities = 664/2546 (26%), Positives = 1129/2546 (44%), Gaps = 262/2546 (10%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
+TA D D G I Y++ G F +D G + ++ +DRE ++ ++
Sbjct: 258 ITAIDQDKGRPRGIGYTIVSG----NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
Query: 139 AKDGD--EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
K + + R A V + D+NDN P FN S Y +I++ Q G +
Sbjct: 314 VKGTELNDDRTPSDATVTTTFNILVI------DINDNAPEFNSSEYSVAITELAQVGFAL 367
Query: 197 ---INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVM 253
I V+ D++ G+ L+ GN S F I T+ ++ I A+ +
Sbjct: 368 PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
Query: 254 NSLEMF----LPLLRHFKKV------ERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQD 303
++F +P + KV E D + + + + + D
Sbjct: 427 YDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATD 486
Query: 304 EAASADGEAAARYVANLAKILGE---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN 360
A GE + + + + + G+I L L + +L + A+DGGG
Sbjct: 487 NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETT-- 544
Query: 361 ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGD 419
V I++ F++ Y + E+ P + + ++A E + I Y I S
Sbjct: 545 GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
Query: 420 LGGKF---SIHPRLGTIRTRKPLDHE--TQPVVVLTVQAQ-LGSAPACSSTEVNITVMDV 473
G + S++ G I +PLD+E + ++ LTV A G+ P S+ V I V D
Sbjct: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE 664
Query: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAED----RDSGRNGLIRYSIASPQPGVFAI 529
NDN P F + + + + + G + A D R+ G+ +I S Q F I
Sbjct: 665 NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRI 721
Query: 530 DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFE 586
+ G + L + E L +RA D GV + TV +++ ++ P+W +
Sbjct: 722 NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW--K 779
Query: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYL 645
Y + + E P + + A + P + L YS++P + + + TG I
Sbjct: 780 DAPYYINLVEMTPPDSDVTTVVA--VDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
Query: 646 RR-QFDYESTQTYNF----RVFAWIPEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVL 697
D E+ + ++ + + G S TV V + D NDN PTF +
Sbjct: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
Query: 698 FLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
+V E +P GV I ++ AID+D G NG + Y + P G
Sbjct: 896 VAEVLEG-IPAGVSIYQVVAIDLDEGLNGLVSYRM--------------PVG-------- 932
Query: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
DF +S G ++ LDRE +++ V+ +D G+
Sbjct: 933 -----MPRMDFLINSSS---------------GVVVTTTELDRERIAEYQLRVVASDAGT 972
Query: 817 PPRNATMAVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875
P +++T + + V D+ND P FFP +V V E P V + D D G N
Sbjct: 973 PTKSSTSTLTIHVLDVNDETPTFFPAVY-----NVSVSEDVPREFRVVWLNCTDNDVGLN 1027
Query: 876 AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ--GQAV 933
AE++Y ++ + F + + +RT L + +Y + + A D G + G A
Sbjct: 1028 AELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
Query: 934 VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDK 993
V + V+ ++ R I Q+ +PE++ + +K++D + + G++ + I+ +
Sbjct: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF-GRVWYRILHGNH 1146
Query: 994 DGHFEIDSSTGDLFLS-KELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052
+F I S G L + LD E S ++ V +H + S+V + + VED ND +
Sbjct: 1147 GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PMRSSVRVIVYVEDINDEA 1205
Query: 1053 PSF-QDELIVISVEENVPIGTLVYVFNAKD---DDGSFLNSRIQYYIESHNPGTNPFLIH 1108
P F Q + + + E IGT V V A D DG +N RI E F I
Sbjct: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK------FEID 1259
Query: 1109 PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF 1168
S G ++TV+ LD E+ + ++ V+A+DQA + I +L+ D F +
Sbjct: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG---FCSVYITLLNELDEAVQFSNA 1316
Query: 1169 P-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNENMTFMLDESSGLLTTT 1224
A + E++ +G+ + + A+ D ++TY + S F +D +G++T
Sbjct: 1317 SYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
Query: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA-SVKENQN 1283
+D E + LTV+A DDG P + S+ + +TVLD ND +P F A S+ E+
Sbjct: 1375 GLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
Query: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPG---ASFELFEINSDTGEVVTTTILDREIQEVF 1340
G+ V V+A D D+G N ++ F + G +FE+ N GEV LDRE + +
Sbjct: 1434 VGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHY 1493
Query: 1341 TLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS---YDIEVLENQEP-EVVYTVL 1396
L+V+ D G P + T+ D ND+ P ++ S Y++ V EN V V
Sbjct: 1494 ILQVVASDRGTPPRKKDHILQVTILDINDNPP--VIESPFGYNVSVNENVGGGTAVVQVR 1551
Query: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRAL-DREQISNFTLVILCSDLGD 1455
A+D D G N + Y+I +GN D F ++ +SGE++T A DRE+ S + LV D G
Sbjct: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGT 1611
Query: 1456 PPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAE-VGTVVLVLSAVDKDEGLNGQTE 1514
P S+ H+ V ++D ND++P F +Y+ + E + + T ++ + A+D DEG NG
Sbjct: 1612 PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT 1671
Query: 1515 Y-FLTDEASGAFTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARD-CSIQGSRST-TVIIK 1570
Y + F ID G + + LD E + ++T A D C I R T T +
Sbjct: 1672 YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVL 1731
Query: 1571 VYVTDVNDNDPVLEQN---PFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS 1627
V V D+NDN P ++ PF+V P T + A D D GPNG V +S +
Sbjct: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFL---AHDRDSGPNGQVEYSIMDGDP 1788
Query: 1628 M--FSIDKYTGEIQFQQNPSSEYFPIW---LQLKVTDQGIPARTTTGLLVIHM----EGE 1678
+ F I G ++ +++ + I L + D+G+P ++T L+ I + + +
Sbjct: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
Query: 1679 DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS 1737
V ++ ++ ++EN + + V A DS + ++I +GN + + + +
Sbjct: 1849 PVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATT 1905
Query: 1738 GQLTVKEPKFLDFEVRNEVQLIVLAESS------GHRAYCKVAVLIQDENDNSPCFEQSI 1791
G +TV P LD E E +L + + + R Y + + + DENDN P F +S
Sbjct: 1906 GIVTVNRP--LDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
Query: 1792 YQASVSESQLYNAHVI----QVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
YQA V E+ + + A D D + ++ Y +L G Q F I++ +GV+T +
Sbjct: 1964 YQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVR 2022
Query: 1848 A--ILDYELTSS--YSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902
+ I+D E S L++ A D G+ L++T + + + D NDN P F P+ V + E
Sbjct: 2023 SGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLE 2080
Query: 1903 DSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVV-VLVKTLDFEEMT 1959
+ PG V V+ D D LN ++ E+ +F I TGV+ V T+D EE
Sbjct: 2081 NCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTGVIRVGNATIDREEQE 2138
Query: 1960 EYELLIQISD-SVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Y L + +D G +V +L D+ND+ P F V+V ES G + ++A
Sbjct: 2139 SYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITA 2198
Query: 2017 TDLESNENISYRIL-------------SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFL 2063
D + N + Y I+ + F+++ G++ SP + + ++T +
Sbjct: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP-MNRELVATYEVT 2257
Query: 2064 VEASDGGNPDL--RALTL----VEIGIEDMNNYAPEFT---VKSYNLSLSEDALVGSTLV 2114
+ D + DL R++++ + + + D+N+ P+F + Y + E A G+TL+
Sbjct: 2258 LSVIDNAS-DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Query: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
+ +D D N V Y+++ +E G ++ ++D E
Sbjct: 2317 AVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLEDS---------SAGKVIANRTVDYEEVH 2366
Query: 2175 SHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSA 2234
+ ASD+G PP ++ + ++++D+NDN P F SY V E P+G+ I V+A
Sbjct: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
Query: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD----- 2289
D D+G+ A I Y++ G K F + TG +Y++ LD EK + LT A D
Sbjct: 2427 TDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDV 2484
Query: 2290 AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
A + + V + VLD ND PQF FS V EN P +++ ++ A D D GP GEL
Sbjct: 2485 ASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGEL 2544
Query: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT--A 2407
TYS+ P + F +D +G + ++ L ++ K+ LTV A D G+
Sbjct: 2545 TYSLEGP---------GVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWG 2593
Query: 2408 SLVVWVDIEGIDEFEPIFTQ--DQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG 2465
+ ++ V++ +++ P+F + + + E+ R + V A+D D G++G + YS
Sbjct: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL 2653
Query: 2466 TSS-----PFFSVNKTNGNIYLIRAL 2486
++ FF ++ +G I + L
Sbjct: 2654 KTAGNRDWEFFIIDPISGLIQTAQRL 2679
Score = 615 bits (1585), Expect = e-175
Identities = 653/2343 (27%), Positives = 1027/2343 (43%), Gaps = 243/2343 (10%)
Query: 310 GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 369
GE A+R+ A G+++L PL + ++ S D G VI V I +
Sbjct: 71 GEEASRFFAVEPDT---GVVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGD 124
Query: 370 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 428
F Y+ + E+ P +PI V A +P L + + Y F+I
Sbjct: 125 VNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDS 182
Query: 429 RLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486
G + + LD+ET LTV A Q + P + + I + DV D P F+
Sbjct: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
Query: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 545
I + +PPGT + + A D+D GR I Y+I S +FA+D GVL LNG L
Sbjct: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302
Query: 546 E---QRELTLTLRAEDQGVH--PQAALLVLT---VVIEKREHSPSWTFEHLVYQVEVSES 597
LT++ + P A + T +VI+ +++P F Y V ++E
Sbjct: 303 NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE--FNSSEYSVAITEL 360
Query: 598 LS-----PMTQMLQTQAHPLGPQR-------AASPLRYSLEPSVDSAMFGIRPYTGWIYL 645
P+ + + LG + + + P+ IR I +
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR-----IRV 415
Query: 646 RRQFDYESTQTYNFRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 703
DYE+ Y+F +FA +P+ V T+I +ENDN P F + + + E
Sbjct: 416 AIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLI----NENDNRPIFSQPLYNISLYE 471
Query: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
+ + + A D D+G G++ YF D F ++ +TG
Sbjct: 472 NVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------ 513
Query: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVA-LDREHRGHHEMTVLVTDRGSPPRNAT 822
LI +A LD E +T++ D G T
Sbjct: 514 ---------------------------LIMLIARLDYELIQRFTLTIIARDGGG--EETT 544
Query: 823 MAVYVSVTDINDNRPFFPQCLPGKELHVKVL-EGQPVNMLVTTVFAKDPDEGNNAEVTYS 881
V ++V D+NDN P F K+ +V L E +P + + A D D N ++TYS
Sbjct: 545 GRVRINVLDVNDNVPTFQ-----KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYS 599
Query: 882 VSSEDS-SDHFKIDANNGEIRTTTILSYDYRPSYR----MSVIATDQGVPPLQGQAVVNI 936
+ S + +F I G + DY ++V+A D G PPL V I
Sbjct: 600 IVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTI 659
Query: 937 QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996
+V + S+ + + EN+ + + ++D + G+ I + +
Sbjct: 660 EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI-IYSLEGSTQ 718
Query: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTD----HSKNLSLSSTVFLSIDVEDQNDHS 1052
F I++ +G++ + LD ET S Y+ V D H++ +++ ++I + D ND+
Sbjct: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT---VNITLLDINDNH 775
Query: 1053 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
P+++D I++ E P + V A D D N + Y I+ P + ++ + G
Sbjct: 776 PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE-NGTLVYSIQ---PPNKFYSLNSTTG 831
Query: 1113 TLVTV-SRLDRESIPTVILTVTASDQAVNVTD------RRLRSLTAQIVILDVNDHNPTF 1165
+ T + LDRE+ P V+VTD + S T + +LD+ND++PTF
Sbjct: 832 KIRTTHAMLDREN-PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
Query: 1166 ISFPN-AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224
+ P A V E + G ++ + A D DEG NG V+Y + G M F+++ SSG++ TT
Sbjct: 891 QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT 950
Query: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
LD E ++ L V+A D GTP SS+ TLT+ VLDVNDE P F +Y SV E+ P
Sbjct: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV-P 1009
Query: 1285 GEF-VTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343
EF V + D D G+N++L + I G F + V T LDRE + L
Sbjct: 1010 REFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
Query: 1344 VLVRDGG--FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDM 1400
+ D G + T T+ TV D ND+ P F+ SSY+ V E+ E + + A+D
Sbjct: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
Query: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELST-TRALDREQISNFTLVILC--SDLGDPP 1457
D G V Y I+ GN F I+ +G L R LDRE+ S+ L++ DLG P
Sbjct: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PM 1188
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYY-QSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516
RSSV + V V D ND +P F Y + +RE A +GT V+V+ A D+D G G Y
Sbjct: 1189 RSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
Query: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
+ A G F ID +G + T N LD E ++ + + A D Q VY+T +
Sbjct: 1248 ILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATD---QAPPFNQGFCSVYITLL 1304
Query: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-----AETQSMFSI 1631
N+ D ++ + + T IVR + + + F + +++F I
Sbjct: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKI 1364
Query: 1632 DKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIP-ARTTTGLLVIHMEGEDVKISFSHHLYK 1690
D TG I Q E + V D G P +T + + ++ D F
Sbjct: 1365 DAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
Query: 1691 GL-VTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS---GQLTVKEP 1745
+ + E+C G + TVKA+ PD+ + +S+ SGN G + + + G++ V P
Sbjct: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
Query: 1746 KFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSI-YQASVSESQL 1801
LD E + L V+A G K + V I D NDN P E Y SV+E+
Sbjct: 1485 --LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVG 1542
Query: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK-AILDYELTSSYSL 1860
V+QV ATD D G+N ++ Y I GN++ AF++D +SG I T+ A D E S Y L
Sbjct: 1543 GGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
Query: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTH-VSVHDVD 1919
+ D+G P LS TT + V + D NDNAP F E+ D P + T +++ +D
Sbjct: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQALD 1661
Query: 1920 L----NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYT 1974
L N ++ N F ID++ GV+ K LD+E Y L++ +D
Sbjct: 1662 LDEGPNGTVTYAIV-AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
Query: 1975 EGAL------VVRVLDVNDNPPVFSQDF---YQVTVPESIPVGYSVLTLSATDLESNEN- 2024
L +V V D+NDN P F +D+ ++VT E P G V T A D +S N
Sbjct: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNG 1777
Query: 2025 -ISYRILSSSK--EFSIDPKNGTIFTISPVLL-LDTISTTQFLVEASDGGNPDLRALTLV 2080
+ Y I+ EF I P G + V L +TI+ + A D G P L + LV
Sbjct: 1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1837
Query: 2081 EIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQ 2140
I + D+N+ P N+++SE++ V S + D D + N + ++I +GN +
Sbjct: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD-SGCNARLTFNITAGNRE 1896
Query: 2141 NNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTA---VIS 2197
F + G + + LDRE ++L I D+ P + ++
Sbjct: 1897 RAFFINA----------TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 2198 IQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS----ANDRDTGSHAEIIYNIISGN 2253
I + D NDN P F+ +Y V E++P G+ +TV++ A D D +A + Y ++ G
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2005
Query: 2254 EKGHFYLEENTGVLYLIKP--LDYEKMTK--FTLTVQASDAEKKHFSFAVVFVSVLDDND 2309
+ G F + +TGV+ + +D E + L + A D + S A + +++LDDND
Sbjct: 2006 QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN-STAHLLITILDDND 2064
Query: 2310 HAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL 2369
+ P F ++ + + EN P ++ + A D D+G GEL Y I + D
Sbjct: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA---------QDR 2115
Query: 2370 FLIDPLTGDIH-AKQILDYENGNKYCLTVQAKDKGDA--TASLVVWVDIEGIDEFEPIFT 2426
FLI +TG I +D E Y LTV A D+G + + +V + I+ I++ P F
Sbjct: 2116 FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
Query: 2427 QDQYFFTLPEKNKDRQLIGRVEASDADAG------IDGVILYS-----LGTSSPFFSVNK 2475
++ E + +I + A D D I G++ + F+VN
Sbjct: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
Query: 2476 TNGNIYLIRALPLIKSQLNKE--DTLEMKIIAHSPKSDSKFASCTV-----FVNVSFSSE 2528
G++ ++KS +N+E T E+ + SD S +V VNV ++
Sbjct: 2236 NTGSV-------MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
Query: 2529 GTP 2531
TP
Sbjct: 2289 NTP 2291
Score = 598 bits (1542), Expect = e-170
Identities = 591/2094 (28%), Positives = 932/2094 (44%), Gaps = 169/2094 (8%)
Query: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQ 547
IS+ TP G+++ A+D D N + + ++ + FA++ GV++L L +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 548 RELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 606
E T+ D QGV + V V + +++P TF + Y V + E+ T +
Sbjct: 99 SEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAP--TFHNQPYSVRIPENTPVGTPIFI 153
Query: 607 TQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664
A LG A + YS +P S F I G + + R+ DYE+TQ Y V A
Sbjct: 154 VNATDPDLG---AGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
+ + + + + D D P F++ + E P + ITAID D G+
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
Query: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784
+ Y ++S G +I+ + + G +G + F+L
Sbjct: 269 RGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
Query: 785 ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844
EL + DR T + V DINDN P F
Sbjct: 318 ELND------------------------DRTPSDATVTTTFNILVIDINDNAPEF----N 349
Query: 845 GKELHVKVLEGQPVNM---LVTTVFAKDPDEG-NNAEVTYSVSSEDSSDHFKIDANN--- 897
E V + E V L V KD + G N+ Y V ++S HF I +
Sbjct: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG--NNSHHFIISPTSVQG 407
Query: 898 -GEIRTTTILSYDYRPSYRMSV-IATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955
+IR + DY R + ++ VP G A V I +I + R I SQ + ++
Sbjct: 408 KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
Query: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
+ EN+ + + ++D+ + +F +DD D F +D TG + L LDYE
Sbjct: 468 SLYENVTVGTSVLTVLATDNDAGTFGEVSYF--FSDDPD-RFSLDKDTGLIMLIARLDYE 524
Query: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVY 1075
+ +I D +T + I+V D ND+ P+FQ + V ++ EN P T +
Sbjct: 525 LIQRFTLTIIARDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
Query: 1076 VFNAKDDDGSFLNSRIQYYIESHNPGTNPF--LIHPSFGTLVTVSRLDRESIPTVILTVT 1133
A D+D S N++I Y I S + + F ++ +G + LD E I ++ +T
Sbjct: 582 RLRATDED-SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
Query: 1134 ASDQAVNVTDRRLRS-LTAQIVILDVNDHNPTFISFPN--AHVKEDVTVGSLVHHITAHD 1190
A++ + L S + I + D ND+ PTF S P V E++ G+ V + A D
Sbjct: 641 V--MAMDAGNPPLNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATD 697
Query: 1191 PDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGT--PA 1248
D R I S + F ++ SG +TTT LD E K+++IL V A+D G
Sbjct: 698 LDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 757
Query: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
+ T+ +T+LD+ND P +K Y ++ E P VT V A+D D G N L + I
Sbjct: 758 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817
Query: 1309 MPGASFELFEINSDTGEVVTT-TILDR------EIQEVFTLRVLVRDGGFPSLSSTT--T 1359
P F + +NS TG++ TT +LDR E + + + V V D G P L +T+ T
Sbjct: 818 QPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
Query: 1360 ILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTD 1418
+ + D ND+ P F + EVLE V +Y V+A D+D G N V Y + G
Sbjct: 876 VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
Query: 1419 ECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSF 1478
F IN SG + TT LDRE+I+ + L ++ SD G P +SS L + VLD ND +P+F
Sbjct: 936 MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
Query: 1479 PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT-DEASGAFTIDPMSGTLKTS 1537
Y SV ED V+ L+ D D GLN + YF+T G F++ ++T
Sbjct: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
Query: 1538 NTLDREARSQHTFSAVARDCSIQGSRST-TVIIKVYVTDVNDNDPVLEQNPFDVFLSPES 1596
LDRE + + A D G R T T + V V DVNDN P+ Q+ ++ + +
Sbjct: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
Query: 1597 PTNQTTVIVRADDLDLGPNGTVVFSFAETQ--SMFSIDKYTGEIQFQQNP----SSEYFP 1650
P + + ++A D D G G V + + F I G + P +
Sbjct: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
Query: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL-VTENCEAGTSIVTVKAF 1709
+ ++ D G P R++ ++V + D F+ Y L + E GTS++ V+A
Sbjct: 1176 LIVEAYNHDLG-PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234
Query: 1710 APDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-- 1766
DS + Y I SG E G + +G + +LD+E + + V A
Sbjct: 1235 DRDSGDGGLVNYRILSGAE-GKFEIDESTGLIIT--VNYLDYETKTSYMMNVSATDQAPP 1291
Query: 1767 -HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYS 1825
++ +C V + + +E D + F + Y+A++ E+ +++V A +D+ ++
Sbjct: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFN 1351
Query: 1826 ILSGNQEEA-FQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
+ Q +A F+IDA++GVIT + ++D E Y+L V A D G P++ +T + + V D
Sbjct: 1352 AYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLD 1410
Query: 1885 INDNAPA--FLPSEAVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAI 1940
NDN+P F AV I ED G V V D D N +FS A + G +
Sbjct: 1411 ENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIV 1470
Query: 1941 DQN--TGVVVLVKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQD 1995
N G V + + LD EE+ Y L + SD + L V +LD+NDNPPV
Sbjct: 1471 TTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESP 1530
Query: 1996 F-YQVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKE--FSIDPKNGTIFTISP 2050
F Y V+V E++ G +V+ + AT D+ N +SY I +K+ F +D +G I T
Sbjct: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPA 1590
Query: 2051 VLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA-LV 2109
+ S + D G P L A T V + I D N+ AP F Y + L E +
Sbjct: 1591 PPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL 1650
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
++L+T +D D N V Y+I++GN N F ++ + +G + LD
Sbjct: 1651 NTSLITIQALDLD-EGPNGTVTYAIVAGNIVNTFRID----------RHMGVITAAKELD 1699
Query: 2170 REASASHELVILASDSGCPPLS----STAVISIQVLDVNDNPPNF-SSLSYHTHVKESTP 2224
E S +I+ + CP LS ST + + V D+NDN P F V E P
Sbjct: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
Query: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK--PLDYEKMTKFT 2282
G + A+DRD+G + ++ Y+I+ G+ G F + GVL + K LD E + +
Sbjct: 1760 -GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYN 1818
Query: 2283 LTVQASDAEKKHFSFA-VVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341
LT+ A D S +V + VLD ND+ P + + + EN P+SS + + A D
Sbjct: 1819 LTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDA 1878
Query: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401
D+G LT++I + F I+ TG + + LD E +Y LT+ KD
Sbjct: 1879 DSGCNARLTFNITA--------GNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
Query: 2402 KGDATASL-----VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD----RQLIGRVEASDA 2452
+ ++ + + ++ P+FT+ Y + E + L G + A DA
Sbjct: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
Query: 2453 DAGIDGVILYS-LGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA 2505
D I V+ Y LG S F +N + G + +R+ +I + LE+ ++A
Sbjct: 1991 DQDIYAVVTYQLLGAQSGLFDINSSTG-VVTVRSGVIIDREAFSPPILELLLLA 2043
Score = 578 bits (1491), Expect = e-164
Identities = 618/2184 (28%), Positives = 970/2184 (44%), Gaps = 218/2184 (9%)
Query: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATY 133
T V A D D G G + YS+ + P F ++ G+I + +DRE DP
Sbjct: 798 TTVVAVDPDLGENGTLVYSI-------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEA 850
Query: 134 DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193
+L+ + +T ++ A V V+L D+NDN P F +V + + G
Sbjct: 851 ELMRKIVVS----VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
Query: 194 TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI---------LSAV 244
I V+A D D G+ G V+Y + G F I+S++G+ E+ L V
Sbjct: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
Query: 245 NFSADKEVMNSLEMFLPLLRHFKKVERDEEA---AEKKFEASRGWFMRFKGRRHLHYLKV 301
A +S L H V + A S F+ + +L
Sbjct: 967 ASDAGTPTKSSTS---TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR----VVWLNC 1019
Query: 302 QDEAASADGEAAARYVANLAKILG-------EGIIYLTLPLSHLESTTLSLMVSAQDGG- 353
D + E + Y + G + ++ + L + L++ A D G
Sbjct: 1020 TDNDVGLNAELS--YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
Query: 354 -GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPI 411
G A V + + F + Y V ED+PE I +KA + +
Sbjct: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
Query: 412 FYRISSGDLGGKFSIHPRLGTI-RTRKPLDHETQPVVVLTVQA---QLGSAPACSSTEVN 467
+YRI G+ G F IH G + R +PLD E VL V+A LG P SS V
Sbjct: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG--PMRSSVRVI 1195
Query: 468 ITVMDVNDNHPAFLRTS-DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV 526
+ V D+ND P F + + + +T GT++ + +A DRDSG GL+ Y I S G
Sbjct: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 586
F ID + G++ L + + + A DQ + + + E + F
Sbjct: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITL-LNELDEAVQFS 1314
Query: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 646
+ Y+ + E+L+ T++++ QA+ + + + + A+F I TG I ++
Sbjct: 1315 NASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
Query: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSP--TFLHDVLFLKVEE 703
D E Y V A +DG + ST V + V DENDNSP F D E+
Sbjct: 1375 GLVDREKGDFYTLTVVA---DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
Query: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
PV Q V + A D D+G NGQ+++ L S AG ++T D
Sbjct: 1432 CPVGQRV-ATVKAWDPDAGSNGQVVFSLASG----------NIAGAFEIVTTNDSI---- 1476
Query: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 823
GE+ LDRE H+ + V+ +DRG+PPR
Sbjct: 1477 -------------------------GEVFVARPLDREELDHYILQVVASDRGTPPRKKDH 1511
Query: 824 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 883
+ V++ DINDN P +V V E V V A D D G N+ ++Y ++
Sbjct: 1512 ILQVTILDINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
Query: 884 SEDSSDHFKIDANNGEIRTTTILSYDYRPS-YRMSVIATDQGVPPLQGQAVVNIQVIPLS 942
+ F++D +GEI T R S Y + D+G P L V + ++ +
Sbjct: 1569 EGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
Query: 943 KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSS 1002
+ Q +++ E + + L + NG + ++IVA + F ID
Sbjct: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH 1688
Query: 1003 TGDLFLSKELDYETT-SHYLFRVITTDHSKNLS--LSSTVFLSIDVEDQNDHSPSF-QDE 1058
G + +KELDYE + Y V TD LS L+ST + ++V D ND+ P+F +D
Sbjct: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
Query: 1059 LIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVS 1118
V E P G V+ F A D D S N +++Y I +P F+I P G L
Sbjct: 1749 EGPFEVTEGQP-GPRVWTFLAHDRD-SGPNGQVEYSIMDGDP-LGEFVISPVEGVLRVRK 1805
Query: 1119 --RLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKE 1175
LDRE+I LT+ A D+ + ++ I +LD+ND++P ++ P N + E
Sbjct: 1806 DVELDRETIAFYNLTICARDRGMPPLS---STMLVGIRVLDINDNDPVLLNLPMNITISE 1862
Query: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235
+ V S V H+ A D D G N ++T++I +GN F ++ ++G++T PLD E ++
Sbjct: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
Query: 1236 ILTVLALDDGTP---ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT--- 1289
LT+ D+ A L + + D ND P+F + Y+A V EN G +T
Sbjct: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
Query: 1290 -RVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT--ILDREIQEVFTLRVLV 1346
+ ALD D + + + ++++ GA LF+INS TG V + I+DRE L +L+
Sbjct: 1983 GPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
Query: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNN 1405
L+ST +L T+ D+ND+ P F ++ + +LEN P V V A+D D+G N
Sbjct: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
Query: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRA-LDREQISNFTLVILCSDLGDPPRSSVIHL 1464
+ Y I G D F I+ ++G + A +DRE+ ++ L ++ +D G P S +
Sbjct: 2102 GELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
Query: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF-------- 1516
+ + D ND P F SV E AE GTV+ ++A+D D LN + EY
Sbjct: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKD 2218
Query: 1517 ----LTDEASGAFTIDPMSGTLKTSNTLDRE--ARSQHTFSAV--ARDCSIQGSRSTTVI 1568
L AF ++ +G++ + ++RE A + T S + A D +
Sbjct: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
Query: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSP--ESPTNQTTVI-VRADDLDLGPNGTVVFSFAET 1625
+ V V DVNDN P + ++ E T TT+I V A D D G NG V ++ +
Sbjct: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 2338
Query: 1626 QSMFSI---DKYTGEIQFQQNPSSEYFPI-WLQ--LKVTDQGIPARTTTGLLVIHMEGED 1679
+ D G++ N + +Y + WL ++ +D G P R + +++E D
Sbjct: 2339 VPPGYVQLEDSSAGKV--IANRTVDYEEVHWLNFTVRASDNGSPPRAAE--IPVYLEIVD 2394
Query: 1680 VKIS---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCS 1735
+ + F Y+ V E+ GT I+TV A DS ++ +YS+ G+ + ++
Sbjct: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINP 2452
Query: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAES-----SGHRAYCKVAVLIQ--DENDNSPCFE 1788
+G + V LD E ++ L LA+ + +R V V+IQ D ND P F
Sbjct: 2453 TTGDIYVLSS--LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
Query: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITT-K 1847
+ + SV E++ VI + ATD D G NG + YS L G EAF +D SG++TT +
Sbjct: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS-LEGPGVEAFHVDMDSGLVTTQR 2569
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL--PSEAVEITEDSL 1905
+ YE +SL V ATD G P L TT++ V+V D+NDN P F+ P+ + + +
Sbjct: 2570 PLQSYE---KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEI 2626
Query: 1906 P---GVIVTHVSVHDVDLNSAFIFSFAKE--SNPGTKFAIDQNTGVVVLVKTLDFEEMTE 1960
P V + + D LN A +SF K + F ID +G++ + LD E
Sbjct: 2627 PLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV 2686
Query: 1961 YELLIQISD---SVHY-TEGALVVRVLDVNDNPPVF------SQDFYQVTVPESIPVGYS 2010
Y L++ SD V Y T L V + D++DN P+F S + +TVPE P G
Sbjct: 2687 YSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
Query: 2011 VLTLS-ATDLESNEN-ISYRILSS---SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065
V ++ A D + N I Y +++ K F + P +G + + L + + F+V+
Sbjct: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRD-LDREREAIFSFIVK 2804
Query: 2066 ASD--------GGNPDL---RALTLVEIGI--EDMNNYAPEFTVKSYNLSLSEDALVGST 2112
AS G +P L LTL E+ + ED+N+ P FT Y ++ DA VGS
Sbjct: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
Query: 2113 LVTFSNIDHDWTRENTYVEYSIIS 2136
L+ +D D N+ V YSI++
Sbjct: 2865 LIQVLALDAD-IGNNSLVFYSILA 2887
Score = 520 bits (1340), Expect = e-147
Identities = 537/2023 (26%), Positives = 872/2023 (43%), Gaps = 178/2023 (8%)
Query: 327 GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386
G++ T L L V A D G T + +TIH+ F Y V
Sbjct: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 387 YEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 445
EDVP + + + + + + + Y I+ G++ GKFS+ R +RT LD ET
Sbjct: 1005 SEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTA 1064
Query: 446 VVVLTVQAQLGSAPA----CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 501
+L ++A + + P + V +TV+DVNDN P FL++S E + + P G ++
Sbjct: 1065 AYMLILEA-IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
Query: 502 ARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELT--LTLRAED 558
+A D D G G + Y I G F I + G+L + G +R + L + A +
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEAYN 1182
Query: 559 QGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 617
+ P ++++ V+ V + + +P +T + ++ + E+ T ++ QA
Sbjct: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFT-QQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
Query: 618 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 677
+ Y + + F I TG I DYE+ +Y V A F Q +
Sbjct: 1242 GL-VNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCS- 1298
Query: 678 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 737
V + + +E D + F + + E+ I ++ A +D+ Q+ Y
Sbjct: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITY-------- 1348
Query: 738 FKMNPNTGP-AGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVA 796
+ N T A ++ I G G
Sbjct: 1349 -RFNAYTSTQAKALFKIDAITGVITVQGL------------------------------- 1376
Query: 797 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 856
+DRE + +TV V D G P ++T+ VY++V D NDN P F + V + E
Sbjct: 1377 VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFT---SDSAVSIPEDC 1432
Query: 857 PVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN---GEIRTTTILSYDYRPS 913
PV V TV A DPD G+N +V +S++S + + F+I N GE+ L +
Sbjct: 1433 PVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDH 1492
Query: 914 YRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI-IPENLKPTKIMSLIKS 972
Y + V+A+D+G PP + ++ + ++ ++ ++ + + + EN+ + +++
Sbjct: 1493 YILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
Query: 973 SDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
+D N L + I +KD F +D +G++ + V T +
Sbjct: 1553 TDR-DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGT 1611
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVP-IGTLVYVFNAKD-DDGSFLNSR 1090
+LS+T + + + D+ND++P FQ + ++E + T + A D D+G N
Sbjct: 1612 PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGP--NGT 1669
Query: 1091 IQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRE-SIPTVILTVTASDQAVNVTDRRLRSL 1149
+ Y I + N N F I G + LD E S L VTA+DQ ++ R +
Sbjct: 1670 VTYAIVAGNI-VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTT 1728
Query: 1150 TAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNE 1208
T + + D+ND+ PTF + + G V AHD D G NG+V YSI+ G+
Sbjct: 1729 TVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDP 1788
Query: 1209 NMTFMLDESSGLLTTT--CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1266
F++ G+L LD E + LT+ A D G P LSS+ + + VLD+ND
Sbjct: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
Query: 1267 PVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEV 1326
PV ++ EN FV V A D DSG N++L F I G F IN+ TG V
Sbjct: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV 1908
Query: 1327 VTTTILDREIQEVFTLRVLVRDGGF-PSLSSTT--TILCTVEDENDHAPEFIVSSYDIEV 1383
LDRE + L + V+D P ++ +L + DEND+ P F S+Y EV
Sbjct: 1909 TVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEV 1968
Query: 1384 LENQEPEVVYTVL-----ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRA--L 1436
+EN TVL A D D V Y ++ G F IN +G ++ +
Sbjct: 1969 MENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVII 2027
Query: 1437 DREQISN--FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVG 1494
DRE S L++L D+G +S HL + +LD ND+ P+F + E+ G
Sbjct: 2028 DREAFSPPILELLLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPG 2085
Query: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSN-TLDREARSQHTFSAV 1553
VL ++A D+D GLNG+ Y + A F I ++G ++ N T+DRE + + + V
Sbjct: 2086 FSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
Query: 1554 ARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI-VRADDLDL 1612
A D S T I+ + + D+ND+ P NP ES T + + A D DL
Sbjct: 2146 ATDRGTV-PLSGTAIVTILIDDINDSRPEF-LNPIQTVSVLESAEPGTVIANITAIDHDL 2203
Query: 1613 GPN------GTVVFSFAET-----QSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQ 1660
P G V + + F+++ TG + + + E + + L V D
Sbjct: 2204 NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDN 2263
Query: 1661 G---------IP-ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFA 1710
+P A+ T +L ++ K F Y + E GT+++ V A
Sbjct: 2264 ASDLPERSVSVPNAKLTVNVLDVNDNTPQFK-PFGITYYMERILEGATPGTTLIAVAAVD 2322
Query: 1711 PDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG--- 1766
PD + + Y++ G + L S + + +D+E + + V A +G
Sbjct: 2323 PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPP 2381
Query: 1767 HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSI 1826
A V + I D NDN+P F+Q YQ +V E ++ V ATD DSG LIEYS+
Sbjct: 2382 RAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
Query: 1827 LSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDK----GMPRLSNTTVIKVQV 1882
G+ E F I+ +G I + LD E Y L A D R N+ + +QV
Sbjct: 2442 --GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Query: 1883 TDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAID 1941
D+ND P F P + + E+ G V + D D +++ E F +D
Sbjct: 2500 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVD 2559
Query: 1942 QNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQ--DF 1996
++G+V + L E ++ L + +D + L+V V+DVNDN PVF + +
Sbjct: 2560 MDSGLVTTQRPLQSYE--KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
Query: 1997 YQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE-----FSIDPKNGTIFTIS 2049
+ + E IP+ +V + ATD + N + Y L ++ F IDP +G I T
Sbjct: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ 2677
Query: 2050 PVLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFT-----VKSYNLSL 2103
L ++ + ++ ASD G P + +++ +ED+++ P F Y L
Sbjct: 2678 R-LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT 2736
Query: 2104 SEDALVGSTLV--TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
+ TLV +D D N V Y I +GN + NFH++ G
Sbjct: 2737 VPEHSPRGTLVGNVTGAVDAD-EGPNAIVYYFIAAGNEEKNFHLQPD-----------GC 2784
Query: 2162 LVLLHSLDREASASHELVILASDSGC--------PPLSSTAVISIQVL-----DVNDNPP 2208
L++L LDRE A ++ AS + P L A +++Q + D+ND PP
Sbjct: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
Query: 2209 NFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
F+ Y V +GS + V A D D G+++ + Y+I++
Sbjct: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILA 2887
Score = 514 bits (1324), Expect = e-145
Identities = 493/1761 (27%), Positives = 807/1761 (45%), Gaps = 131/1761 (7%)
Query: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
+ ++ + E PV VT + A+D D N + + VS E++S F ++ + G + L
Sbjct: 37 DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPL 93
Query: 907 SYDYRPSYRMSVIATD-QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
+ + + + +D QGV + VNIQV ++ + IPEN
Sbjct: 94 DRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
Query: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
+ ++ ++D G + +S + F IDS+ G + + +ELDYETT Y V
Sbjct: 150 PIFIVNATDP-DLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVN 206
Query: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGS 1085
TD K LS+ L+I + D D P F + ++ E+ P GT V + A D D
Sbjct: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
Query: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES---IPTVILTVTASDQAVNVT 1142
I Y I S N + F + G L LDRE+ ILTV ++ +
Sbjct: 267 RPRG-IGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE----LN 320
Query: 1143 DRRLRS-----LTAQIVILDVNDHNPTFISFP-NAHVKEDVTVG-SLVHHITAHDPDEGR 1195
D R S T I+++D+ND+ P F S + + E VG +L I D DE
Sbjct: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
Query: 1196 NGKVTYSI-LSGNENMTFMLDESSG------LLTTTCPLDYEMKTQHILTVLALDDGTPA 1248
+ + L GN + F++ +S + PLDYE ++ + A ++ P
Sbjct: 381 GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPD 439
Query: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
+ +T+++ ND P+F Q LY S+ EN G V V A D D+G ++ +
Sbjct: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
Query: 1309 MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN 1368
+ F ++ DTG ++ LD E+ + FTL ++ RDGG +T + V D N
Sbjct: 500 SDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVN 555
Query: 1369 DHAPEFIVSSYDIEVLENQEPEVVYTV--LASDMDAGNNRAVEYHIIDGNTDECF---TI 1423
D+ P F +Y + L EP V V A+D D+ N + Y I+ + + ++
Sbjct: 556 DNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
Query: 1424 NEMSGELSTTRALDREQISN--FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481
E G +S +R LD EQISN L ++ D G+PP +S + + + V D ND+ P+F
Sbjct: 615 YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 674
Query: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLN-GQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
Y SV E+ G VL L+A D D GQ + E S F I+ SG + T++ L
Sbjct: 675 AYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
Query: 1541 DREARSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
DRE +S++ A D + ++ T + + + + D+NDN P + P+ + L +P +
Sbjct: 735 DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
Query: 1600 QTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQF------QQNPSSEYFPIW- 1652
V A D DLG NGT+V+S +S++ TG+I+ ++NP +
Sbjct: 795 SDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
Query: 1653 -LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
+ + VTD G P A ++ + V ++ D +F + + V E AG SI V A
Sbjct: 855 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
Query: 1709 FAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH 1767
D + + Y + G + S SG V LD E E QL V+A +G
Sbjct: 915 IDLDEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASDAGT 972
Query: 1768 RAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
+ L + D ND +P F ++Y SVSE V+ + TD D GLN + Y
Sbjct: 973 PTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1032
Query: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGM--PRLSNTTVIKVQV 1882
I GN + F + V+ T LD E T++Y LI++A D G R + T + V V
Sbjct: 1033 FITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTV 1092
Query: 1883 TDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNS-AFIFSFAKESNPGTKFAI 1940
D+NDN P FL S + ED G + + D D ++ N G F I
Sbjct: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
Query: 1941 DQNTGVVVL-VKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQDF 1996
+ G+++ + LD E + + L+++ + + ++V V D+ND PVF+Q
Sbjct: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
Query: 1997 Y-QVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK-EFSIDPKNGTIFTISPVL 2052
Y ++ + E+ +G SV+ + ATD +S + ++YRILS ++ +F ID G I T++ L
Sbjct: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVN-YL 1271
Query: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+T ++ V A+D P + V I + + + A +F+ SY ++ E+ +G+
Sbjct: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTE 1331
Query: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
+V D + TY + S ++ F ++ G + + +DRE
Sbjct: 1332 IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA----------ITGVITVQGLVDREK 1381
Query: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS-YHTHVKESTPLGSHITV 2231
+ L ++A D G P + ST + I VLD NDN P F S + E P+G +
Sbjct: 1382 GDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
Query: 2232 VSANDRDTGSHAEIIYNIISGNEKGHFYL---EENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
V A D D GS+ ++++++ SGN G F + ++ G +++ +PLD E++ + L V AS
Sbjct: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
Query: 2289 D-----AEKKHFSFAVVFVSVLDDNDHAPQFMFS-SFSCIVPENLPISSTICSINALDFD 2342
D +K H ++ V++LD ND+ P ++ V EN+ + + + A D D
Sbjct: 1501 DRGTPPRKKDH----ILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD 1556
Query: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDL-FLIDPLTGDIHAKQI-LDYENGNKYCLTVQAK 2400
G L+Y ++T G + D+ F +D ++G+I + D E + Y L +
Sbjct: 1557 IGINSVLSY------YITEG---NKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
Query: 2401 DKGDATASLVVWVDIEGIDEFE--PIFTQDQYFFTLPE--KNKDRQLIGRVEASDADAGI 2456
D+G T S V + +DE + P+F Q Y L E + LI ++A D D G
Sbjct: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGP 1666
Query: 2457 DGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQ----LNKEDTLEMKIIAHSPKS 2510
+G + Y++ G F +++ G I + L S L T + I++H S
Sbjct: 1667 NGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTS 1726
Query: 2511 DSKFASCTVFVNVSFSSEGTP 2531
+ TV VNV+ ++ P
Sbjct: 1727 -----TTTVLVNVNDINDNVP 1742
Score = 464 bits (1194), Expect = e-130
Identities = 520/1942 (26%), Positives = 840/1942 (43%), Gaps = 251/1942 (12%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLL 136
++ A+DAD G +G + Y + G FRI +G + + +DRER+ +++ L+
Sbjct: 1123 QLKATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLI 1177
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQP-GTE 195
VEA + D G + + V V +ED+ND PVF Y ET GT
Sbjct: 1178 VEAYNHD----------LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTS 1227
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--------YSPEVEILSAVNFS 247
+I V ATD+DSG G V Y ++ G F ID +TGL Y + + V+ +
Sbjct: 1228 VIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSAT 1286
Query: 248 ADKEVMNS--LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEA 305
N +++ LL + + A+ +EA+ + ++VQ +
Sbjct: 1287 DQAPPFNQGFCSVYITLLNELDEAVQFSNAS---YEAA----ILENLALGTEIVRVQAYS 1339
Query: 306 ASADGEAAAR---YVANLAKILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTA 357
+ R Y + AK L + G+I + + + +L V A DGG
Sbjct: 1340 IDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP--- 1396
Query: 358 VINADVTIHIFQTTLAPAEFERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEP 410
D T+ ++ T L + P++ F +PED P+G TVKA +P S+
Sbjct: 1397 --KVDSTVKVYITVLDEND-NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
Query: 411 IFYRISSGDLGGKFSI---HPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEV 466
+ + ++SG++ G F I + +G + +PLD E +L V A G+ P +
Sbjct: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
Query: 467 NITVMDVNDNHPAFLRTSD-EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG 525
+T++D+NDN P + +++ GTA+ RA DRD G N ++ Y I
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Query: 526 V-FAIDRALGVLFLNGSLGAGEQRELT-LTLRAEDQGVHPQAALL-VLTVVIEKREHSPS 582
+ F +DR G + + E++ L ED+G +A V ++++ +++P
Sbjct: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
Query: 583 WTFEHLVYQVEVSESLSPM-TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPY 639
+ H Y+V + E + T ++ QA L GP + Y++ F I +
Sbjct: 1634 FQQPH--YEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT---YAIVAGNIVNTFRIDRH 1688
Query: 640 TGWIYLRRQFDYE-STQTYNFRVFAW--IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 696
G I ++ DYE S Y V A P +TTV+V V D NDN PTF D
Sbjct: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
Query: 697 L--FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
F E P P+ + A D DSG NGQ+ Y ++ DG P G
Sbjct: 1749 EGPFEVTEGQPGPR--VWTFLAHDRDSGPNGQVEYSIM-DGD---------PLG------ 1790
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
+F S E V K V LDRE + +T+ DR
Sbjct: 1791 -----------EFVISPVEGVLRVRKD-------------VELDRETIAFYNLTICARDR 1826
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
G PP ++TM V + V DINDN P L +++ + E PV+ V V A D D G
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDPV----LLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
NA +T+++++ + F I+A G + L + P Y++++ D P +
Sbjct: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD-- 992
++ +I LS +N H + ++ ++M + L NG + ++ AD
Sbjct: 1943 DLLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTV-LNGPI-LALDADQDI 1994
Query: 993 -----------KDGHFEIDSSTGDLFLSKE--LDYETTSHYLFRVITTDHSKNLSLSSTV 1039
+ G F+I+SSTG + + +D E S + ++ L L+ST
Sbjct: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-LNSTA 2053
Query: 1040 FLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHN 1099
L I + D ND+ P+F + + + EN P G V A D+D S LN + Y IE+
Sbjct: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED-SGLNGELVYRIEAG- 2111
Query: 1100 PGTNPFLIHPSFGTL-VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDV 1158
+ FLIH G + V + +DRE + LTV A+D+ T + I+I D+
Sbjct: 2112 -AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG---TVPLSGTAIVTILIDDI 2167
Query: 1159 NDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSI-----------LSG 1206
ND P F++ V E G+++ +ITA D D N K+ Y I L
Sbjct: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVP 2225
Query: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQT-----LTVTVLD 1261
N+ F ++ ++G + P++ E+ + +T+ +D+ + S + LTV VLD
Sbjct: 2226 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
Query: 1262 VNDEAPVFKQH---LYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF---EIMPGASFE 1315
VND P FK Y + E PG + V A+D D G+N + + +++P +
Sbjct: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
Query: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
L + S G+V+ +D E V D G P ++ + + D ND+ P F
Sbjct: 2346 LED--SSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
Query: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
SY V E+ ++ TV A+D D+GN +EY + DG + F IN +G++
Sbjct: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLS 2461
Query: 1435 ALDREQISNFTLVILCSD----LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED 1490
+LDRE+ ++ L L D + R + + + ++VLD ND P F + +SV E+
Sbjct: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
Query: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTF 1550
GT V+ + A D+DEG NG+ Y L AF +D SG + T L ++ + +
Sbjct: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
Query: 1551 SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS--PESPTNQTTVIVRAD 1608
+ VA D TT+++ V V DVNDN PV + P L E P V A
Sbjct: 2580 TVVATDGGEPPLWGTTMLL-VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
Query: 1609 DLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTD---Q 1660
D D G NG V +SF +T F ID +G IQ Q E ++ + V Q
Sbjct: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
Query: 1661 GIPARTTTGLLVIHMEGEDVKISF------SHHLYKGLVTENCEAGTSI--VTVKAFAPD 1712
+P T L V + +D + F S V E+ GT + VT A +
Sbjct: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
Query: 1713 SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYC- 1771
+ Y I +GNE+ L L ++ D + E + ++S +R++
Sbjct: 2759 GPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----DLDREREAIFSFIVKASSNRSWTP 2813
Query: 1772 -----------------KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
+V V+++D ND P F ++ Y A V+ + +IQV A D
Sbjct: 2814 PRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
Query: 1815 DSGLNGLIEYSIL-----------SGNQEEAFQIDALSGVITTKAILDYELTSSYS---L 1860
D G N L+ YSIL S + + F + ++ G++ T ++L +YS
Sbjct: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT-----FDLFMAYSPGYF 2928
Query: 1861 IVQATDKGMPRLSNTTVIKVQV 1882
+V + + ++T +I + +
Sbjct: 2929 VVDIVARDLAGHNDTAIIGIYI 2950
Score = 342 bits (878), Expect = 2e-93
Identities = 329/1167 (28%), Positives = 525/1167 (44%), Gaps = 98/1167 (8%)
Query: 1372 PEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG 1428
P F +D +L +++ V V +LA DMD N + + + F + +G
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
Query: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVI--HLQVRVLDANDHSPSFPTLYYQSS 1486
+ + LDRE S FT+ SD VI + ++V D ND++P+F Y
Sbjct: 86 VVWLRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
Query: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARS 1546
+ E+ VGT + +++A D D G G Y S F ID G + LD E
Sbjct: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQ 199
Query: 1547 QHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606
+ + A D ST + + +TDV D DP+ P+ + SP T I+
Sbjct: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Query: 1607 ADDLDLG-PNG---TVVFSFAETQSMFSIDKYTGEIQF-----QQNP--SSEYFPIWLQL 1655
A D D G P G T+V T S+F++D +G + ++NP S +
Sbjct: 260 AIDQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
Query: 1656 KVTDQGIP--ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFA 1710
++ D P A TT ++ ++ D F+ Y +TE + G ++ + V
Sbjct: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
Query: 1711 PDSIQDSM--KYSIFSGNEDGVLSLCSKSGQ--LTVKEPKFLDFEVRNEVQLIVLAESS- 1765
+ +SM Y + + + ++S S G+ + ++ LD+E + + A S
Sbjct: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
Query: 1766 -GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
H Y KV + + +ENDN P F Q +Y S+ E+ V+ V ATD D+G G E
Sbjct: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG--EV 495
Query: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
S + + F +D +G+I A LDYEL ++L + A D G T +++ V D
Sbjct: 496 SYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLD 553
Query: 1885 INDNAPAFLPSE---AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAID 1941
+NDN P F A+ E S+ ++ + D N+ +S S G+ F I
Sbjct: 554 VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
Query: 1942 --QNTGVVVLVKTLDFEEMTE--YELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQ 1994
+ GV+ + + LD+E+++ L + D+ + + V + V D NDNPP FS+
Sbjct: 614 LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK 673
Query: 1995 DFYQVTVPESIPVGYSVLTLSATDLE-----SNENISYRILSSSKEFSIDPKNGTIFTIS 2049
Y V+V E+I G +VL L+ATDL+ E+I Y L S +F I+ ++G I T S
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTS 732
Query: 2050 PVLLLDTISTTQFLVEASDG--GNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA 2107
+L +T S +V A DG G+ + V I + D+N+ P + Y ++L E
Sbjct: 733 -LLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
Query: 2108 LVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
S + T +D D T V YSI N KF+ G + H+
Sbjct: 792 PPDSDVTTVVAVDPDLGENGTLV-YSIQPPN---------KFYSLN---STTGKIRTTHA 838
Query: 2168 -LDREASASHE------LVILASDSGCPPL--SSTAVISIQVLDVNDNPPNFSSLSYHTH 2218
LDRE HE +V+ +D G PPL +S+A + + +LD+NDN P F +L +
Sbjct: 839 MLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAE 898
Query: 2219 VKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKM 2278
V E P G I V A D D G + + Y + G + F + ++GV+ LD E++
Sbjct: 899 VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI 958
Query: 2279 TKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN 2337
++ L V ASDA S + + + VLD ND P F + ++ V E++P + +N
Sbjct: 959 AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018
Query: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV 2397
D D G EL+Y F+T G F + + LD E Y L +
Sbjct: 1019 CTDNDVGLNAELSY------FITGGNV--DGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
Query: 2398 QAKDKGDA----TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
+A D G T + V+V + +++ PIF Q Y ++PE + I +++A+DAD
Sbjct: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
Query: 2454 AGIDGVILYSL--GTSSPFFSVNKTNG 2478
G G + Y + G F ++ +NG
Sbjct: 1131 EGEFGRVWYRILHGNHGNNFRIHVSNG 1157
Score = 156 bits (395), Expect = 2e-37
Identities = 231/923 (25%), Positives = 357/923 (38%), Gaps = 135/923 (14%)
Query: 69 ENAKP-VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDR 126
EN P +VTA+D DSGL G + Y + G A F I G I V IDR
Sbjct: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-----AQDRFLIHLVTGVIRVGNATIDR 2134
Query: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVT 184
E + R+T +A +G LS A V + ++D+ND+ P F
Sbjct: 2135 EEQ-------------ESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 185 SISDETQPGTEIINVLATDQDSG------IYGTVAYE----LIPGNVSSLFTIDSTTGLY 234
S+ + +PGT I N+ A D D I G VA + L+P N F ++ TG
Sbjct: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVP-NQEDAFAVNINTG-- 2238
Query: 235 SPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKV-ERDEEAAEKKFEAS----RGWFMR 289
V + S +N +E++ + E+ L ++ + + ER K + +
Sbjct: 2239 --SVMVKSPMN----RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
Query: 290 FKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPL-------------- 335
FK +Y++ E A+ A + K L + Y L L
Sbjct: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAG 2352
Query: 336 --------SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
+ E L+ V A D G V + I F++P Y V+
Sbjct: 2353 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
Query: 388 EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 447
EDVP + I TV A + +S S GD KF+I+P G I LD E +
Sbjct: 2413 EDVPVGTIILTVTATD-ADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHY 2471
Query: 448 VLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 502
+LT A+ S S +V I V+DVND P F + + + P GT++
Sbjct: 2472 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 2531
Query: 503 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 562
A D+D G NG + YS+ P F +D G++ L + E + +LT+ A D G
Sbjct: 2532 MATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYE--KFSLTVVATDGGEP 2589
Query: 563 P-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 621
P ++L VI+ ++ P + + + E + + + + A + +
Sbjct: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD-KDEGLNGAV 2648
Query: 622 RYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTV 678
RYS + D F I P +G I ++ D ES Y+ + A +
Sbjct: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPL 2708
Query: 679 IVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGKIT-AIDMDSGKNGQLLYFL 731
V + D +DN P F+ L V E ++G +T A+D D G N + YF+
Sbjct: 2709 QVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
+ + + N + P G + V+ D + + +F++K+
Sbjct: 2769 AAGNE--EKNFHLQPDGCLLVL-----------RDLDREREAIFSFIVKA-------SSN 2808
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
+W RG LV D V V + DIND P F + E
Sbjct: 2809 RSWT----PPRGPSPTLDLVADL------TLQEVRVVLEDINDQPPRFTKA----EYTAG 2854
Query: 852 VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV-----------SSEDSSDHFKIDANNGEI 900
V V + V A D D GNN+ V YS+ SED F + + +G +
Sbjct: 2855 VATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
Query: 901 RTTTILSYDYRPSY-RMSVIATD 922
RT L Y P Y + ++A D
Sbjct: 2915 RTFD-LFMAYSPGYFVVDIVARD 2936
Score = 142 bits (358), Expect = 5e-33
Identities = 141/518 (27%), Positives = 239/518 (46%), Gaps = 46/518 (8%)
Query: 1990 PVFSQDFYQ--VTVPESIPVGYSVLTLSATDLESNENISYRILS--SSKEFSIDPKNGTI 2045
P F+ F+ + + E PVG SV L A D++ N+ + + + +S+ F+++P G +
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVV 87
Query: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
+ P LD + ++F VE S + + V I + D+N+ AP F + Y++ + E
Sbjct: 88 WLRQP---LDRETKSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
+ VG+ + + D D G+ +F ++FF + G + ++
Sbjct: 144 NTPVGTPIFIVNATDPDLGA----------GGSVLYSFQPPSQFFAID---SARGIVTVI 190
Query: 2166 HSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224
LD E + +++L + A+D PLS+ A ++I + DV D P F +L Y T++ E +P
Sbjct: 191 RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
Query: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK---MTKF 2281
G+ + +++A D+D G I Y I+SGN F L+ +GVL L LD E F
Sbjct: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
Query: 2282 TLTVQAS----DAEKKHFSFAVVF-VSVLDDNDHAPQFMFSSFSCIVPENLPISSTI-CS 2335
LTV+ + D + F + V+D ND+AP+F S +S + E + +
Sbjct: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
Query: 2336 INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLT----GDIHAKQI--LDYEN 2389
I +D D L + + +L S+ F+I P + DI + LDYE
Sbjct: 371 IQVVDKDE----NLGLNSMFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYET 423
Query: 2390 GNKYCLTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVE 2448
++Y + A + D V + + ++ PIF+Q Y +L E + V
Sbjct: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Query: 2449 ASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486
A+D DAG G + Y FS++K G I LI L
Sbjct: 484 ATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARL 521
Score = 72.4 bits (176), Expect = 6e-12
Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 18/156 (11%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
V A+D D G G + YS ++ P Q F ID G + V +++D E A Y L V
Sbjct: 154 VNATDPDLGAGGSVLYS-------FQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTV 205
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
A D D+ R LS A + + + DV D P+F Y T+I + + PGT +
Sbjct: 206 NATDQDKTRP---------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
Query: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
+ A DQD G + Y ++ GN +S+F +D +G+
Sbjct: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV 292
Score = 61.6 bits (148), Expect = 1e-08
Identities = 50/157 (31%), Positives = 69/157 (43%), Gaps = 23/157 (14%)
Query: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
T++ A D D+ F G EA + F ++P G + + Q +DRE +
Sbjct: 53 TQLLAQDMDNDPLVF-------GVSGEEASRFFAVEPDTGVVWLRQPLDRETKS---EFT 102
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
VE D Q G ++ + V + + DVNDN P F+ Y I + T GT I
Sbjct: 103 VEFSVSDHQ---------GVITRK--VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
Query: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
V ATD D G G+V Y P S F IDS G+
Sbjct: 152 FIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGI 186
Score = 60.1 bits (144), Expect = 3e-08
Identities = 59/200 (29%), Positives = 90/200 (45%), Gaps = 30/200 (15%)
Query: 51 RGSPETELWGAIVFRSQEENAKPVKETEVT-ASDADSGLYGFIEYSLYDGFLSYEAPQAF 109
+GSP+ +L E + + VT A DAD G + Y + G + F
Sbjct: 2727 KGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAG----NEEKNF 2777
Query: 110 RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTH-----LALVKGGLSAQAFVR 164
+ P DG + V +D+DRER+ A + +V+A L LV L+ Q VR
Sbjct: 2778 HLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPPRGPSPTLDLV-ADLTLQE-VR 2833
Query: 165 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI------- 217
V LED+ND P F + Y ++ + + G+E+I VLA D D G V Y ++
Sbjct: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRA 2893
Query: 218 ----PGNVSSLFTIDSTTGL 233
+V +FT+ S G+
Sbjct: 2894 LANDSEDVGQVFTMGSMDGI 2913
Score = 40.0 bits (92), Expect = 0.034
Identities = 44/174 (25%), Positives = 81/174 (46%), Gaps = 37/174 (21%)
Query: 65 RSQEENAKPVKETEVTASDADSGLYG-FIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
R+ +E++ P ++T S + +G + + SLY+G+ G I VS+
Sbjct: 584 RATDEDSPP--NNQITYSIVSASAFGSYFDISLYEGY---------------GVISVSRP 626
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPST 181
+D E+ + L+ +T +A+ G L++ V +++ D NDN P F+
Sbjct: 627 LDYEQ--ISNGLIY---------LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA 675
Query: 182 YVTSISDETQPGTEIINVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTG 232
Y S+ + G ++ + ATD D S YG ++ Y L S+ F I++ +G
Sbjct: 676 YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL---EGSTQFRINARSG 726
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 682 bits (1759), Expect = 0.0
Identities = 666/2605 (25%), Positives = 1133/2605 (43%), Gaps = 257/2605 (9%)
Query: 32 EVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGF 91
E+Y+++ + + Q PE E + K V ++ A D DS
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEI----------MENSPKDVSVVQIEAFDPDSSSNDK 1173
Query: 92 IEYSLYDGFLSYEAPQAF-RIDPHDGQICV-SQDIDRERDPATYDLLVEAKDGDEQRMTH 149
+ Y + G PQ F I P G I S+ +DRE+ + +G + T
Sbjct: 1174 LMYKITSG-----NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTI 1228
Query: 150 LALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE-------IINVLAT 202
++ V + D NDN P F Y + + +P E + +V+AT
Sbjct: 1229 ARVI-----------VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIAT 1277
Query: 203 DQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSP-------EVEILSAVNFSADKEVMNS 255
D+D G ++Y + GN F I+ TG+ S E +ILS + +S
Sbjct: 1278 DKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSS 1337
Query: 256 LEMFLPLLRHFKKVERDEEAAEK-KFEASRGWFMRFKGRRHLHYLKVQDEAASAD----G 310
H + + + + + E FE S F + H + V
Sbjct: 1338 TTRL-----HIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFD 1392
Query: 311 EAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 370
Y ++ G G I + PL + + +L V A DG T I V I + T
Sbjct: 1393 ITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDT 1449
Query: 371 TLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG--KFSIHP 428
+F KY ++ ED ++ I + A + ++ I+ SS D KF + P
Sbjct: 1450 NDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDP 1509
Query: 429 RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEI 487
G++ T + LDHE LTV + P + + + V D ND+ P F +S +
Sbjct: 1510 ATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG 1569
Query: 488 RISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGE 546
R+ ++ G+ + A D+D G+N + YSI S G F ID LG + L
Sbjct: 1570 RVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSN 1629
Query: 547 QRELTLTLRAEDQGVHPQAALLVLTVVIEKREH-SPSWTFEHLVYQVEVSESLSPMTQML 605
Q E L ++A D+G P + + + + + ++ SP +T + Y VE+SE++S + +
Sbjct: 1630 QAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE--YSVELSETVSIGSFVG 1687
Query: 606 QTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 665
AH + S + Y ++ F I P++G I ++ D+E+ Y +
Sbjct: 1688 MVTAH------SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTL-IIQGT 1740
Query: 666 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK-------ITAID 718
G N TTV+V + DENDN+P F+ + ES V+ I A D
Sbjct: 1741 NMAGLSTN--TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAAD 1798
Query: 719 MDSGKNGQLLYFLLSDG--KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D N L+Y ++ +F ++ +TG T+ + + + T + ++
Sbjct: 1799 ADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEE-------TSIFHFTVQVHD 1851
Query: 777 FVLKSLFCELGEGELINWVALDR-----------------EHRGHHEMTVLVTDRGSPPR 819
LF E ++ + ++ ++G +TV TD S
Sbjct: 1852 MGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADS--- 1908
Query: 820 NATMAVYVSVTDINDNRPFFPQCLPGK-------------ELHVKVLEGQPVNMLVTTVF 866
+A + S+T+ N F G EL V+ +G+ + +
Sbjct: 1909 SAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKIN 1968
Query: 867 AKDPDEGN---NAEVTYSVSSEDSSD---------------------------HFKIDAN 896
K+ E + +V +V E+S++ FKI
Sbjct: 1969 VKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRT 2028
Query: 897 NGEIRTT-TILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955
+G + TT T + + ++ + V T++ P VV + V + + +
Sbjct: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088
Query: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
++ + + ++ + + D NG++H+ + + HF+I G++ L K+ + +
Sbjct: 2089 VVKVDTEVGHVIRYVTAVDR-DSGRNGEVHYYL--KEHHEHFQI-GPLGEISLKKQFELD 2144
Query: 1016 TTS-HYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLV 1074
T + YL V+ D N + S+ V + I V N P F+ + E++ + + V
Sbjct: 2145 TLNKEYLVTVVAKDGG-NPAFSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPV 2201
Query: 1075 YVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTA 1134
A +G ++ Y I +P + F I+ + G + ++ LD E+ P L++ A
Sbjct: 2202 VHVQANSPEGL----KVFYSITDGDPFSQ-FTINFNTGVINVIAPLDFEAHPAYKLSIRA 2256
Query: 1135 SDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHITAHDPDE 1193
+D + I++ D+ND+ P F A + E +G+ V + A D D
Sbjct: 2257 TDSLTGAH----AEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDS 2312
Query: 1194 GRNGKVTYSILSGNENMT---FMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALS 1250
N ++Y + GN + + F +D S+GL++ LDYE QH + V A+D G P LS
Sbjct: 2313 EPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLS 2371
Query: 1251 SSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMP 1310
S +TV V D+ND P+F+Q +YEA + E+ G FVT V+A D DS KLQ+ I+
Sbjct: 2372 SDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILS 2431
Query: 1311 GASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDH 1370
G + F I+S TG + + + ++ ++L + V DG F S+T + TV N H
Sbjct: 2432 GNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF---RSSTQVHVTVIGGNLH 2488
Query: 1371 APEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGE 1429
+P F+ + Y++E+ EN +V V +D D+G V YHI++ + F INE G+
Sbjct: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQ 2547
Query: 1430 LSTTRALDREQISN--FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
+ T LDRE + ++ ++ D G + + + V + D ND++P F Y+ ++
Sbjct: 2548 IFTLEKLDRETPAEKVISVRLMAKDAGG--KVAFCTVNVILTDDNDNAPQFRATKYEVNI 2605
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA---FTIDPMSGTLKTSNTLDREA 1544
A GT V+ + A D DEG N Y + ++ I+ +SG + T +L
Sbjct: 2606 GSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLE 2665
Query: 1545 RSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE-QNPFDVF-LSPESPTNQTT 1602
TF A D GS S ++ VYV + + + PF F +S + P
Sbjct: 2666 NEFFTFFVRAVD---NGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEI 2722
Query: 1603 VIVRADDLDLGPNGTVVFSF-------AETQSMFSIDKYTGEIQFQQNPSSE-----YFP 1650
++RA+ +GTV++S + F ID+ +G ++ +++ E F
Sbjct: 2723 DLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFS 2777
Query: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFA 1710
I + D + A + V + D F Y+ + EN G+ ++ ++A
Sbjct: 2778 ILARCTQDDHEMVASVDVSIQV--KDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASD 2835
Query: 1711 PDS-IQDSMKYSIFSGNEDGVL---SLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG 1766
DS + YS+ V+ ++ ++G +T K LD E R+ Q+ V+A G
Sbjct: 2836 ADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTL--KELDHEKRDNYQIKVVASDHG 2893
Query: 1767 HRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS-GLNGL 1821
+ V V + D ND+ P F IY+ +VSE + + TD DS +N
Sbjct: 2894 EKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQ 2953
Query: 1822 IEYSILSGNQEEAFQIDALSG--VITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIK 1879
+ Y I G+ F ++ + + K LD E +Y L + ATD S+ +++
Sbjct: 2954 VTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD---GTFSSKAIVE 3010
Query: 1880 VQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF 1938
V+V D NDN+P + + I ED LPG ++ +S D D+ S ++ + KF
Sbjct: 3011 VKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKF 3070
Query: 1939 AIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGALVVRVLDVNDNPPVFSQDFY 1997
++ +TG + LD EE Y LL++ +D + + ++V+ + DVNDN P FS D Y
Sbjct: 3071 KLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPY 3130
Query: 1998 QVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSK-EFSIDPKNGTIFTISPVLLL 2054
+TV E+ G + + ATD ++ N I Y ++ S+ +FSI+ +G I P L
Sbjct: 3131 AITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKP-LDR 3189
Query: 2055 DTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTL 2113
+ + ++A D G P L A V + + D+N+ P F + Y ++SED LVG+ +
Sbjct: 3190 ELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEV 3249
Query: 2114 VTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
+ D N + YSIISGN F +++K G + ++ +LD E+S
Sbjct: 3250 LQVYAASRD-IEANAEITYSIISGNEHGKFSIDSK----------TGAVFIIENLDYESS 3298
Query: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS 2233
+ L + A+D G P LS A +++ V D+NDN P FS +Y T + E L + V
Sbjct: 3299 HEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVM 3358
Query: 2234 ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEK 2292
A+D D S++ I Y+II GN+ F ++ G + + K LD E ++ +TLTVQASD
Sbjct: 3359 ADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSP 3418
Query: 2293 KHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYS 2352
+ V + V D ND+AP F ++S I+ EN P+ ++ + D D+ G
Sbjct: 3419 PRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNG----- 3473
Query: 2353 IVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVW 2412
P F T D F ++P G + + + + Y L V+ D G S + +
Sbjct: 3474 --PPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTY 3530
Query: 2413 VDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTS-SP 2469
+DI I+E + P + F T + +IG++ A+D D + + YSL
Sbjct: 3531 IDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDN 3588
Query: 2470 FFSVNKTNGNIYLIRALPLIKSQLN 2494
FSV+ T G + + L + + LN
Sbjct: 3589 LFSVSSTGGKLIAHKKLDIGQYLLN 3613
Score = 638 bits (1645), Expect = 0.0
Identities = 599/2211 (27%), Positives = 970/2211 (43%), Gaps = 166/2211 (7%)
Query: 344 SLMVSAQDGGGLTAVINADVTIHIF--QTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA 401
+L + A+D G + V IH+ Q P +FE+ Y + E P ++P+ VKA
Sbjct: 333 NLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA 391
Query: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 461
+ + + Y S KFS++ G I +P+ + L V A
Sbjct: 392 ---IPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKA--- 445
Query: 462 SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS 521
ST+V + V+ N N P F +T+ + + P GT + A D D G NG + YSIA+
Sbjct: 446 -STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN 504
Query: 522 PQPGVFAIDRALGVLFLNGSLGAG-EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHS 580
FAID G + + +L R TL +RA D G+ + + VL + +
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLND 564
Query: 581 PSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT 640
+ FE + + + L Q+ A + ++Y +E + F + P +
Sbjct: 565 NTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL---VQYQIEAGNELDFFSLNPNS 621
Query: 641 GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK 700
G + L+R +F DG +N +T + + + + H ++ L+
Sbjct: 622 GVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLYINI------TVAASHKLVNLQ 673
Query: 701 VEESPVPQGVI------------GKITAIDMDS-GKNGQLLYFLLSDGKFFKMNPNTGPA 747
EE+ V + + G++ I DS N + F + ++ N
Sbjct: 674 CEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVG 733
Query: 748 GTIYVITWADGAAAFSG-TDFAFS-SDELQAFVLKSLFCELGEGELINWVALDREHRGHH 805
++ + D F+G +A S +E F++ ++ G L LDRE +
Sbjct: 734 SSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI-----DMETGMLKILSPLDRETTDKY 788
Query: 806 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 865
+ + V D G P + A ++V V D NDN P F Q + V+V E + V+ + V
Sbjct: 789 TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ----ESYFVEVSEDKEVHSEIIQV 844
Query: 866 FAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG- 924
A D D G N VTYS+ ++ +D F ID+ G + L + + + + + A DQ
Sbjct: 845 EATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
Query: 925 -VPPLQGQAVVNIQVIPLSKG-RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
P L VV + + ++ + N R + + + T IM L L Q +G
Sbjct: 903 EEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SG 960
Query: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
++ +S++ D +G+F++D +G + + ++LD+E Y V D K +SLSST ++
Sbjct: 961 QVRYSLL-DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVE 1019
Query: 1043 IDVEDQND--HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNP 1100
++V D N+ H P F + +V+E+ P+G+LV +A D+D + I+Y I
Sbjct: 1020 VEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR-RDGEIRYSIRD-GS 1077
Query: 1101 GTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVND 1160
G F I G + T RLDRES LTV A+DQ V + I + DVND
Sbjct: 1078 GVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLS---SFIEIYIEVEDVND 1134
Query: 1161 HNPTF---ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDES 1217
+ P + +P + E+ V I A DPD N K+ Y I SGN F +
Sbjct: 1135 NAPQTSEPVYYP--EIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPK 1192
Query: 1218 SGLLTTTC-PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA 1276
+GL+TTT LD E + +HIL V D+G+P S+ + V +LD ND P F Q Y+
Sbjct: 1193 TGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKI 1252
Query: 1277 SVKENQNPG-------EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTT 1329
+ E + P E + V A D+D G N+++ + I G F I TG V +
Sbjct: 1253 RLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312
Query: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP 1389
++ +++ + D G P SSTT + H +E + +E
Sbjct: 1313 RFSAAGEYDILSIKAV--DNGRPQKSSTTRL---------HIEWISKPKPSLEPISFEES 1361
Query: 1390 EVVYTVLASDMDAGNNRAVE---------YHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
+TV+ SD A + + I GN D F +++ +G + + LD EQ
Sbjct: 1362 FFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQ 1421
Query: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
SN+ L + + D + + + ++V+D NDH P F T Y+ + ED T +L +
Sbjct: 1422 KSNYNLTV---EATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQI 1478
Query: 1501 SAVDKDEGLNGQTEYFLTDE----ASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARD 1556
SAVD+DE + Y L + F +DP +G+L TS LD EA QHT + + RD
Sbjct: 1479 SAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRD 1536
Query: 1557 CSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNG 1616
+ R+ I+ V V+D ND+ P + + + + + V A D D G N
Sbjct: 1537 QDVPVKRNFARIV-VNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNA 1595
Query: 1617 TVVFSF--AETQSMFSIDKYTGEI----QFQQNPSSEYFPIWLQLKVTDQGIPART-TTG 1669
V++S + F ID G I + ++ +EY L +K TD+G P + T
Sbjct: 1596 EVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYD---LMVKATDKGSPPMSEITS 1652
Query: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
+ + ++ F+ Y ++E G+ + V A + Q S+ Y I GN
Sbjct: 1653 VRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS----QSSVVYEIKDGNTGD 1708
Query: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHRAYCKVAVLIQDENDNSPCFE 1788
+ SG T+ K LDFE LI+ + +G V V +QDENDN+P F
Sbjct: 1709 AFDINPHSG--TIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFM 1766
Query: 1789 QSIYQASVSESQLYNAHVIQ-------VFATDLDSGLNGLIEYSILSGNQEEAFQIDALS 1841
Q+ Y +SES N+ V+ + A D D N L+ Y I+ + F ID+ +
Sbjct: 1767 QAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSST 1826
Query: 1842 GVITTKAILDYELTSSYSLIVQATDKGMPRL--SNTTVIKVQVTDINDNAPAFL-PSEAV 1898
G I T LDYE TS + VQ D G PRL + V V DIND P F P
Sbjct: 1827 GAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEA 1886
Query: 1899 EITEDSLPGVIVTHVSVHDVDLN--SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE 1956
+ + GV V V+ D D + S I+S E N G KF++D TG + + T
Sbjct: 1887 SLLLPTYKGVKVITVNATDADSSAFSQLIYSIT-EGNIGEKFSMDYKTGALTVQNTTQLR 1945
Query: 1957 EMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
+ YEL ++ SD ++ + V + ++ F+QD Y V E+ ++ ++A
Sbjct: 1946 --SRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA 2003
Query: 2017 TDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRA 2076
NE + Y IL+ + F I +G + T + +VE ++ P A
Sbjct: 2004 IGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVA 2063
Query: 2077 LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIIS 2136
+V++ +ED N+ AP F Y + D VG + + +D D R
Sbjct: 2064 HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR----------- 2112
Query: 2137 GNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELV-ILASDSGCPPLSSTAV 2195
H K H + +G + L + + LV ++A D G P S+ +
Sbjct: 2113 ---NGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVI 2169
Query: 2196 ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK 2255
+ I V+ N P F Y + ES + S + V AN + ++ Y+I G+
Sbjct: 2170 VPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSITDGDPF 2224
Query: 2256 GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM 2315
F + NTGV+ +I PLD+E + L+++A+D+ + V + V D ND+ P F
Sbjct: 2225 SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFA 2284
Query: 2316 FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL 2375
S++ + E I +++ + A D D+ P ++Y + F H S+DH F +D
Sbjct: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQM----FGNHSKSHDH--FHVDSS 2338
Query: 2376 TGDIHAKQILDYENGNKYCLTVQAKDKGDATAS--LVVWVDIEGIDEFEPIFTQDQYFFT 2433
TG I + LDYE ++ + V+A D G T S ++V VD+ +++ P+F Q Y
Sbjct: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
Query: 2434 LPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
+ E + V+A DAD+ + YS+ G F ++ G I L
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449
Score = 599 bits (1545), Expect = e-170
Identities = 656/2596 (25%), Positives = 1114/2596 (42%), Gaps = 293/2596 (11%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
E A V+A+DAD G G YS D F I P G I ++ +D
Sbjct: 160 ENTAIRTSIARVSATDADIGTNGEFYYSFKD------RTDMFAIHPTSGVIVLTGRLD-Y 212
Query: 128 RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 187
+ Y++ + A D + G+S+ A + V +E N+ PV T S
Sbjct: 213 LETKLYEMEILAADRGMK-----LYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSEL 267
Query: 188 DETQPGTEIINVLATDQDSGIYGTVA-YELIPGNVSSLF-TIDSTTGLYSPEVEILSAVN 245
D P I+ V D D G G +A ++ G++ F T+ S G +V+ + ++
Sbjct: 268 DR-DPAYAIVTV--DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGID 324
Query: 246 FSA------------DKEV---MNSLEMFLPLLRHFK----KVERDEEAAE-KKFEASRG 285
+ + DK +S+++ FK K E+D AE +F
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
Query: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSL 345
+ K +L+ ++ + + Y G+I + P+ ++ L
Sbjct: 385 PVVMVKAIPAYSHLRYVFKSTPGKAKFSLNY--------NTGLISILEPVKRQQAAHFEL 436
Query: 346 MVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPL 405
V+ D T V+ + + P EF + Y E+VP + + ++ A +P
Sbjct: 437 EVTTSDRKASTKVL-----VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP- 490
Query: 406 NSSEPIFYRISSGDLGG-KFSIHPRLGTIRTRKPLDHETQP-VVVLTVQAQLGSAPACSS 463
+ E + S +L F+I G + T + LD+E P V L ++A P
Sbjct: 491 DEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
Query: 464 TEV--NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-- 519
EV IT+ ++NDN P F + + E I + G + A D D + L++Y I
Sbjct: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEA 608
Query: 520 --------ASPQPGVFAIDRAL------------------------GVLFLNGSLGAGEQ 547
+P GV ++ R+L L++N ++ A +
Sbjct: 609 GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHK 668
Query: 548 RELTLTLRAEDQGVHPQAA--LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQML 605
+ L+ E+ GV A LL + + E + H V + + S + +
Sbjct: 669 ---LVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV-NAHIPQFRSTLPTGI 724
Query: 606 QTQAH-PLGPQ-----------RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 653
Q + + P+G L Y++ + + F I TG + + D E+
Sbjct: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET 784
Query: 654 TQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 712
T Y + + + G Q + ++ V V D NDN P FL + F++V E I
Sbjct: 785 TDKYTLNITVY--DLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII 842
Query: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
++ A D D G NG + Y +++D F ++ TG V+ A
Sbjct: 843 QVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTG------VVNIAR--------------- 881
Query: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD--RGSPPRNATMAVYVSVT 830
LDRE + H + + D R P +T+ V VS+
Sbjct: 882 -----------------------PLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
Query: 831 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH 890
D+NDN P F +P VKV E P ++ + A DPD G + +V YS+ + +
Sbjct: 919 DVNDNPPTF---IP-PNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL-LDHGEGN 973
Query: 891 FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP-PLQGQAVVNIQVIPLSKG--RAI 947
F +D +G +R L ++ + Y ++V A D+G P L V ++V+ +++ +
Sbjct: 974 FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
Query: 948 MSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLF 1007
S + + E+ ++ + + D +G++ +SI G F+I TG +
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDE-DARRDGEIRYSIRDGSGVGVFKIGEETGVIE 1092
Query: 1008 LSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEEN 1067
S LD E+TSHY V TD + LSS + + I+VED ND++P + + + EN
Sbjct: 1093 TSDRLDRESTSHYWLTVFATDQGV-VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151
Query: 1068 VPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSR-LDRESIP 1126
P V A D D S N ++ Y I S NP F IHP G + T SR LDRE
Sbjct: 1152 SPKDVSVVQIEAFDPDSS-SNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 1127 TVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF------ISFPNAHV--KEDVT 1178
IL VT +D N + + + ILD ND+ P F I P +E
Sbjct: 1210 EHILEVTVTD---NGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNA 1266
Query: 1179 VGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTT---TCPLDYEMKTQH 1235
++H+ A D DEG N +++YSI GNE+ F ++ +G++++ + +Y+
Sbjct: 1267 RREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD----- 1321
Query: 1236 ILTVLALDDGTPALSSSQTLTVTVLD---VNDEAPVFKQHLYEASVKENQNPGEFVTRVE 1292
IL++ A+D+G P SS+ L + + + E F++ + +V E+ + +
Sbjct: 1322 ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 1293 ALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP 1352
G+ L F+I G F+++ TG ++ LD E + + L V DG
Sbjct: 1382 V--EPPGI--PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG--- 1434
Query: 1353 SLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYH 1411
+ + T + V D NDH P+F S Y++ + E+ PE + + A D D N +
Sbjct: 1435 TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKL---IY 1491
Query: 1412 IIDGNTD----ECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVR 1467
+ + D + F ++ +G L T+ LD E + TL ++ D P + + + V
Sbjct: 1492 TLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVN 1551
Query: 1468 VLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-TDEASGAFT 1526
V D NDH+P F Y+ V E A VG+VVL ++A+DKD+G N + Y + + +F
Sbjct: 1552 VSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFM 1611
Query: 1527 IDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVNDNDPVLE 1584
IDP+ G++KT+ LDR ++++ A D +GS S ++++VT ++ P
Sbjct: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATD---KGSPPMSEITSVRIFVTIADNASPKFT 1668
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYTGEIQFQQ 1642
+ V LS +V A +VV+ + T F I+ ++G I Q+
Sbjct: 1669 SKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQK 1723
Query: 1643 NPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGT 1701
E PI+ L + + +T +++H++ E D F Y GL++E+ +
Sbjct: 1724 ALDFETLPIY-TLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINS 1782
Query: 1702 SIVTVKAF-----APDSIQDS---MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
++T + A D+ +DS + Y I + ++ S +G + LD+E
Sbjct: 1783 VVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG--AIHTVLSLDYEET 1840
Query: 1754 NEVQLIVLAESSG-HRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
+ V G R + + V V + D ND P F + +Y+AS+ VI
Sbjct: 1841 SIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT 1900
Query: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
V ATD DS + YSI GN E F +D +G +T + +L S Y L V+A+D
Sbjct: 1901 VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASD-- 1956
Query: 1869 MPRLSNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS 1927
R + T +K+ V + ++ F + + E+S + ++ +N +
Sbjct: 1957 -GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYH 2015
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKT-LDFEEMTEYELLIQISDSVHYTEGA-LVVRVL-- 1983
NP +F I + +GV+ T D E+ +++++++++ + A +VV+V+
Sbjct: 2016 IL---NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVE 2072
Query: 1984 DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPK 2041
D NDN PVF Y V VG+ + ++A D +S N + Y + + F I P
Sbjct: 2073 DQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPL 2132
Query: 2042 NGTIFTISPVLLLDTISTTQFL-VEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
++ LDT++ + V A DGGNP A +V I + MN P F Y+
Sbjct: 2133 GE--ISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFYS 2188
Query: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
++E V S +V + E V YSI G+ + F + G
Sbjct: 2189 AEIAESIQVHSPVVHVQAN----SPEGLKVFYSITDGDPFSQFTINF----------NTG 2234
Query: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
+ ++ LD EA +++L I A+DS + + I V D+NDNPP F+ SY +
Sbjct: 2235 VINVIAPLDFEAHPAYKLSIRATDS-LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLS 2293
Query: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKG--HFYLEENTGVLYLIKPLDYEKM 2278
E++ +G+ + V A D D+ + I Y + + K HF+++ +TG++ L++ LDYE+
Sbjct: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
Query: 2279 TKFTLTVQASDAEKKHFSF-AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN 2337
+ T+ V+A D S +V V V D ND+ P F + + E+ P + +
Sbjct: 2354 RQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK 2413
Query: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV 2397
A D D+ +L YSI+S DH F+ID TG I + + Y L +
Sbjct: 2414 AYDADSSDIDKLQYSILS--------GNDHKHFVIDSATGIITLSNLHRHALKPFYSLNL 2465
Query: 2398 QAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGID 2457
D G +S V V + G + P F Q++Y L E L+ V+ +D D+GI
Sbjct: 2466 SVSD-GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIY 2524
Query: 2458 GVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFA 2515
G + Y + + F +N+ G I+ + L + E + ++++A + K A
Sbjct: 2525 GHVTYHIVNDFAKDRFYINE-RGQIFTLEKL---DRETPAEKVISVRLMAKD--AGGKVA 2578
Query: 2516 SCTVFVNVSFSSEGTP 2531
CTV V ++ ++ P
Sbjct: 2579 FCTVNVILTDDNDNAP 2594
Score = 592 bits (1527), Expect = e-168
Identities = 676/2574 (26%), Positives = 1102/2574 (42%), Gaps = 272/2574 (10%)
Query: 64 FRSQEENAKPVKETE--------VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHD 115
FRS VKE + + ++D D+G G + Y++ G F ID
Sbjct: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGG----NEDSCFMIDMET 771
Query: 116 GQICVSQDIDRERDP------ATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLED 169
G + + +DRE YDL + K R+ H+ +V D
Sbjct: 772 GMLKILSPLDRETTDKYTLNITVYDLGIPQKAA--WRLLHVVVV---------------D 814
Query: 170 VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 229
NDN P F +Y +S++ + +EII V ATD+D G G V Y ++ + F+IDS
Sbjct: 815 ANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDS 872
Query: 230 TTGLYS------PEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEAS 283
TG+ + E++ ++ A + ++F ++ K D F
Sbjct: 873 VTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVV--VKVSLEDVNDNPPTFIPP 930
Query: 284 RGWFMRFKGRRHL------HYLKVQDEAASADGEAAARYV----ANLAKILGEGIIYLTL 333
R K R L +L+ D G+ + N G + +
Sbjct: 931 N---YRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQ 987
Query: 334 PLSHLESTTLSLMVSAQDGG---GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 390
L + +L V A+D G L++ +V + L P F V ED
Sbjct: 988 QLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDA 1047
Query: 391 PEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVL 449
P S + TV A E I Y I G G F I G I T LD E+ L
Sbjct: 1048 PVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWL 1107
Query: 450 TVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEI---RISQTTPPGTALYLARAE 505
TV A G P S E+ I V DVNDN P +TS+ + I + +P ++ A
Sbjct: 1108 TVFATDQGVVPLSSFIEIYIEVEDVNDNAP---QTSEPVYYPEIMENSPKDVSVVQIEAF 1164
Query: 506 DRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNG-SLGAGEQRELTLTLRAEDQGVHP 563
D DS N + Y I S P G F+I G++ L +Q E L + D G P
Sbjct: 1165 DPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP 1224
Query: 564 QAALL-VLTVVIEKREHSPSWTFEHLVYQVEVSESLSP---MTQMLQTQAHPLGPQRAAS 619
++ + V+ ++++ ++ P F Y++ + E P + H + +
Sbjct: 1225 KSTIARVIVKILDENDNKPQ--FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEG 1282
Query: 620 P---LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 676
P + YS+E + F I P TG + +R + + Y+ + ++G Q ST
Sbjct: 1283 PNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAV-DNGRPQKSST 1338
Query: 677 TVIVRVWDENDNSP----TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
T + W +F V ES +IG I+ G L+F +
Sbjct: 1339 TRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-----EPPGIPLWFDI 1393
Query: 733 SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELI 792
+ G + D F D+ G G +I
Sbjct: 1394 TGGNY----------------------------DSHFDVDK-------------GTGTII 1412
Query: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKV 852
LD E + ++ +TV TD + V++ V D ND+RP F + V +
Sbjct: 1413 VAKPLDAEQKSNYNLTVEATDGTT---TILTQVFIKVIDTNDHRPQFST----SKYEVVI 1465
Query: 853 LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSED-SSDHFKIDANNGEIRTTTILSYDYR 911
E + + A D DE N T S + S F++D G + T+ L ++
Sbjct: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
Query: 912 PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIK 971
+ ++V+ DQ VP + A + + V + + + + E+ ++ +
Sbjct: 1526 HQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVT 1585
Query: 972 SSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDH-S 1030
+ D + N ++ +SI + + F ID G + +KELD + Y V TD S
Sbjct: 1586 ALDK-DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGS 1644
Query: 1031 KNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSR 1090
+S ++V + + + D + SP F + + + E V IG+ V + A S
Sbjct: 1645 PPMSEITSVRIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHS------QSS 1696
Query: 1091 IQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLT 1150
+ Y I+ N G + F I+P GT++T LD E++P L + ++ A T + T
Sbjct: 1697 VVYEIKDGNTG-DAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLST-----NTT 1750
Query: 1151 AQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHH-------ITAHDPDEGRNGKVTYS 1202
+ + D ND+ P F+ + E ++ S+V I A D D+ N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 1203 ILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSS--SQTLTVTVL 1260
I+ + + F +D S+G + T LDYE + TV D GTP L + + +TV V+
Sbjct: 1811 IVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
D+ND PVF + LYEAS+ G V V A D DS S+L + I G E F ++
Sbjct: 1871 DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMD 1930
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD 1380
TG + T +++ + L V DG F L T++ V++ + +F Y
Sbjct: 1931 YKTGAL--TVQNTTQLRSRYELTVRASDGRFAGL---TSVKINVKESKESHLKFTQDVYS 1985
Query: 1381 IEVLENQ-EPEVVYTVLASDMDAGN--NRAVEYHIIDGNTDECFTINEMSGELSTT-RAL 1436
V EN E E + + A GN N + YHI+ N D F I+ SG LSTT
Sbjct: 1986 AVVKENSTEAETLAVITA----IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPF 2039
Query: 1437 DREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVREDAEVG 1494
DREQ F +V+ ++ P S+V H+ V+V+ D ND++P F L Y + V+ D EVG
Sbjct: 2040 DREQQEAFDVVVEVTEEHKP--SAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVG 2097
Query: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSG-TLKTSNTLDREARSQHTFSAV 1553
V+ ++AVD+D G NG+ Y+L E F I P+ +LK LD ++ + V
Sbjct: 2098 HVIRYVTAVDRDSGRNGEVHYYL-KEHHEHFQIGPLGEISLKKQFELD-TLNKEYLVTVV 2155
Query: 1554 ARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLG 1613
A+D G+ + + + V +T +N PV E+ + ++ + V V+A+
Sbjct: 2156 AKD---GGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN----S 2208
Query: 1614 PNGTVVF---SFAETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTG 1669
P G VF + + S F+I+ TG I E P + L ++ TD A
Sbjct: 2209 PEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF 2268
Query: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQD-SMKYSIFSGNED 1728
+ +I + D F+ Y ++E GTS+V V+A DS + + Y +F +
Sbjct: 2269 VDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK 2328
Query: 1729 GVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSP 1785
S + + LD+E + + V A G V V + D NDN P
Sbjct: 2329 SHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPP 2388
Query: 1786 CFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVIT 1845
FEQ IY+A +SE + V V A D DS ++YSILSGN + F ID+ +G+IT
Sbjct: 2389 LFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT 2448
Query: 1846 TKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDS 1904
+ + L YSL + +D G+ R ++T + V V N ++PAFL +E VE+ E++
Sbjct: 2449 LSNLHRHALKPFYSLNLSVSD-GVFR--SSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
Query: 1905 LPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEM 1958
+V V D D + + FAK+ +F I++ G + ++ LD E
Sbjct: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKD-----RFYINER-GQIFTLEKLDRE-- 2557
Query: 1959 TEYELLIQISDSVHYTEGALV-----VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013
T E +I + G + V + D NDN P F Y+V + S G SV+
Sbjct: 2558 TPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVK 2617
Query: 2014 LSATDLE--SNENISYRILSSS----KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEAS 2067
+ A+D + SN +I+Y I + S + I+ +G I T ++ L+ T F V A
Sbjct: 2618 VLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFT-FFVRAV 2676
Query: 2068 DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTREN 2127
D G+P ++ LV + I P+F+ Y ++SED +G T + +H T
Sbjct: 2677 DNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIG-TEIDLIRAEHSGT--- 2732
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILA-SDSG 2186
V YS++ GN+ + E+ +Q G L L SLD E + ++ ILA
Sbjct: 2733 --VLYSLVKGNTPESNRDESFVID-----RQSGRLKLEKSLDHETTKWYQFSILARCTQD 2785
Query: 2187 CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEII 2246
+ ++ +SIQV D NDN P F S Y + E+ P GS + + A+D D+G++ +++
Sbjct: 2786 DHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVM 2845
Query: 2247 YNIISGNEK---GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK--HFSFAVVF 2301
Y++ F + TG + +K LD+EK + + V ASD +K S A+V
Sbjct: 2846 YSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVD 2905
Query: 2302 VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYG-ELTYSIVSPCFLT 2360
V+V D ND P+F + V E+ P I ++ D D+ ++TY F+T
Sbjct: 2906 VTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTY------FIT 2959
Query: 2361 HGMSYDHDLFLIDPLTGD--IHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGI 2418
G F ++ + + ++ K+ LD E + Y LT+ A D G ++ +V V +
Sbjct: 2960 GGDPLGQ--FAVETIQNEWKVYVKKPLDREKRDNYLLTITATD-GTFSSKAIVEVKVLDA 3016
Query: 2419 DEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS-LGTSSPFFSVNKTN 2477
++ P+ + Y T+PE +LI ++ A+DAD + I Y+ LG+ + F +N
Sbjct: 3017 NDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDT 3076
Query: 2478 GNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
G + + L++E+ ++ + +F ++ + + ++ P
Sbjct: 3077 GEL-------KTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAP 3123
Score = 568 bits (1465), Expect = e-161
Identities = 546/2061 (26%), Positives = 890/2061 (43%), Gaps = 237/2061 (11%)
Query: 585 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT--GW 642
F HL Y V V E+ + T + + A +RY + +F Y +
Sbjct: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
Query: 643 IYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 696
+LR + +T N + + E T V V+V D ND P F
Sbjct: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153
Query: 697 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
+ + E+ + I +++A D D G NG+ Y F ++P +G + V+T
Sbjct: 154 YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG----VIVLTG- 208
Query: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR-- 814
LD +EM +L DR
Sbjct: 209 ---------------------------------------RLDYLETKLYEMEILAADRGM 229
Query: 815 ---GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD 871
GS ++ + V + N+ P + L L+ P +VT D D
Sbjct: 230 KLYGSSGISSMAKLTVHIEQANECAP----VITAVTLSPSELDRDPAYAIVT---VDDCD 282
Query: 872 EGNNAEV-TYSVSSEDSSDHFKI-----DANNGEIRTTTILSYDYRP-SYRMSVIATDQG 924
+G N ++ + S+ + D F+ + +++ + +D P Y +++ A D+G
Sbjct: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKG 342
Query: 925 VPP-LQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGK 983
PP V+++ G +++ I E P + ++K+
Sbjct: 343 TPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSH----- 397
Query: 984 LHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSI 1043
L + + F ++ +TG + + + + + +H+ V T+D +ST L +
Sbjct: 398 LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVL-V 451
Query: 1044 DVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGT 1102
V N + P F + +ENVPIGT V +A D D+G N + Y I + N
Sbjct: 452 KVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGE--NGYVTYSIANLN--H 507
Query: 1103 NPFLIHPSFGTLVTVSRLDRESIPTV-ILTVTASDQAVNVTDRRLRSLTAQIVILDVNDH 1161
PF I G + T LD E +P V L + ASD + RR + A I + ++ND+
Sbjct: 508 VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY--RREVEVLATITLNNLNDN 565
Query: 1162 NPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGL 1220
P F + D+ VG + ++A D DE + V Y I +GNE F L+ +SG+
Sbjct: 566 TPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLNPNSGV 623
Query: 1221 LT-----------------------------TTCPLDYEMKTQHILTVLALDD-GTPALS 1250
L+ T ++ + H L L ++ G +
Sbjct: 624 LSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKML 683
Query: 1251 SSQTLTVTVL--------------DVNDEAPVFKQHLYEA-SVKENQNPGEFVTRVEALD 1295
+ + L L VN P F+ L VKENQ G V + + D
Sbjct: 684 AEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTD 743
Query: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
D+G N KL + + G F I+ +TG + + LDRE + +TL + V D G P +
Sbjct: 744 LDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA 803
Query: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIID 1414
+ + V D ND+ PEF+ SY +EV E++E + V A+D D G N V Y I+
Sbjct: 804 AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV- 862
Query: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG--DPPRSSVIHLQVRVLDAN 1472
+ F+I+ ++G ++ R LDRE +L I D +P S + ++V + D N
Sbjct: 863 -TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN 921
Query: 1473 DHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSG 1532
D+ P+F Y+ VRED GTV++ L A D D G +GQ Y L D G F +D +SG
Sbjct: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG 981
Query: 1533 TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDN--DPVLEQNPFDV 1590
++ LD E + + + A+D S S+T ++V V DVN+N PV
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ--SMFSIDKYTGEIQ----FQQNP 1644
+ ++P + V A D D +G + +S + +F I + TG I+ +
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
Query: 1645 SSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGT 1701
+S Y WL + TDQG+ + + I++E EDV + S +Y + EN
Sbjct: 1102 TSHY---WLTVFATDQGVV--PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDV 1156
Query: 1702 SIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV 1760
S+V ++AF PD S D + Y I SGN G S+ K+G +T K LD E ++E L V
Sbjct: 1157 SVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRK-LDREQQDEHILEV 1215
Query: 1761 LAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAH-------VIQVF 1810
+G +V V I DENDN P F Q Y+ + E + + + V
Sbjct: 1216 TVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVI 1275
Query: 1811 ATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI-VQATDKGM 1869
ATD D G N I YSI GN+ F I+ +GV+++K + Y ++ ++A D G
Sbjct: 1276 ATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYDILSIKAVDNGR 1332
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLPSEAVE--ITEDSLPGVIVTH-VSVHDVDLNSAFIF 1926
P+ S+TT ++ + I+ P+ P E T + V H + V V+ ++
Sbjct: 1333 PQKSSTT--RLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLW 1390
Query: 1927 SFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVN 1986
N + F +D+ TG +++ K LD E+ + Y L ++ +D + ++V+D N
Sbjct: 1391 FDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTN 1450
Query: 1987 DNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSS-----KEFSIDPK 2041
D+ P FS Y+V +PE +L +SA D + + Y + SS K+F +DP
Sbjct: 1451 DHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPA 1510
Query: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
G+++T S L + + V D P R + + + D N++AP FT SY
Sbjct: 1511 TGSLYT-SEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG 1569
Query: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
+ E A VGS ++ + +D D +N V YSI SGN N+F ++ +G
Sbjct: 1570 RVYESAAVGSVVLQVTALDKD-KGKNAEVLYSIESGNIGNSFMID----------PVLGS 1618
Query: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
+ LDR A ++L++ A+D G PP+S + I V ++ P F+S Y + E
Sbjct: 1619 IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSE 1678
Query: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKF 2281
+ +GS + +V+A+ S + ++Y I GN F + ++G + K LD+E + +
Sbjct: 1679 TVSIGSFVGMVTAH-----SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIY 1733
Query: 2282 TLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICS------ 2335
TL +Q ++ + V V + D+ND+AP FM + ++ ++ E+ I+S + +
Sbjct: 1734 TLIIQGTNMAGLSTN-TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL 1792
Query: 2336 -INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
I A D D L Y IV P H F ID TG IH LDYE + +
Sbjct: 1793 VIRAADADKDSNALLVYHIVEPSV--------HTYFAIDSSTGAIHTVLSLDYEETSIFH 1844
Query: 2395 LTVQAKDKGD----ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEAS 2450
TVQ D G A + V V + I++ P+F + Y +L + V A+
Sbjct: 1845 FTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNAT 1904
Query: 2451 DADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSP 2508
DAD+ ++YS+ G FS++ G + +++ E+ + A
Sbjct: 1905 DADSSAFSQLIYSITEGNIGEKFSMDYKTGAL-------TVQNTTQLRSRYELTVRA--- 1954
Query: 2509 KSDSKFASCT-VFVNVSFSSE 2528
SD +FA T V +NV S E
Sbjct: 1955 -SDGRFAGLTSVKINVKESKE 1974
Score = 551 bits (1421), Expect = e-156
Identities = 591/2213 (26%), Positives = 958/2213 (43%), Gaps = 211/2213 (9%)
Query: 50 KRGSPETELWGAIVFRSQEENAKPV---KETEVTASDADS--GLYGFIE--------YSL 96
K P +E+ +F + +NA P KE V S+ S G + Y +
Sbjct: 1642 KGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEI 1701
Query: 97 YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGG 156
DG AF I+PH G I + +D E P Y L+++ T++A G
Sbjct: 1702 KDG----NTGDAFDINPHSGTIITQKALDFETLPI-YTLIIQG--------TNMA----G 1744
Query: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN-------VLATDQDSGIY 209
LS V V L+D NDN PVF + Y IS+ + ++ + A D D
Sbjct: 1745 LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSN 1804
Query: 210 GTVAYELIPGNVSSLFTIDSTTG----LYSPEVEILSAVNFSADKEVMNSLEMFLPLLRH 265
+ Y ++ +V + F IDS+TG + S + E S +F+ M + +F +
Sbjct: 1805 ALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAAN 1864
Query: 266 FKKVERDEEA-----AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANL 320
D A+ +EAS +KG + + A AD A ++ + ++
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASL-LLPTYKGVK-----VITVNATDADSSAFSQLIYSI 1918
Query: 321 AK-ILGE--GIIYLTLPLSHLESTTL----SLMVSAQDG--GGLTAVINADVTIHIFQTT 371
+ +GE + Y T L+ +T L L V A DG GLT+V I++ ++
Sbjct: 1919 TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSV-----KINVKESK 1973
Query: 372 LAPAEFERPKYTFLVYEDVPEDSPIGTVKA-REPLNSSEPIFYRISSGDLGGKFSIHPRL 430
+ +F + Y+ +V E+ E + + A P+N EP+FY I + D +F I
Sbjct: 1974 ESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDR--RFKISRTS 2029
Query: 431 GTIRTR-KPLDHETQPVVVLTVQAQLGSAP-ACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
G + T P D E Q + V+ P A + V + V D NDN P F+
Sbjct: 2030 GVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE-Q 547
+ T G + A DRDSGRNG + Y + F I LG + L
Sbjct: 2090 VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEH-FQIG-PLGEISLKKQFELDTLN 2147
Query: 548 RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 607
+E +T+ A+D G +A +++ + + + FE Y E++ES+ + ++
Sbjct: 2148 KEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMP---VFEKPFYSAEIAESIQVHSPVVHV 2204
Query: 608 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
QA+ P+ + YS+ + F I TG I + D+E+ Y + A
Sbjct: 2205 QAN--SPE--GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSL 2260
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 727
G V +IV D NDN P F + + E+ V + ++ A D DS N +
Sbjct: 2261 TGAHAEVFVDIIVD--DINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGI 2318
Query: 728 LYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELG 787
Y + G + S F S +L++L
Sbjct: 2319 SYQMF-------------------------GNHSKSHDHFHVDSSTGLISLLRTL----- 2348
Query: 788 EGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 847
D E H + V D G P ++ + V V VTD+NDN P F Q +
Sbjct: 2349 ----------DYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQI---- 2394
Query: 848 LHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILS 907
++ E P VT V A D D + ++ YS+ S + HF ID+ G I + +
Sbjct: 2395 YEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHR 2454
Query: 908 YDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIM 967
+ +P Y +++ +D GV + V++ VI + QN + + EN ++
Sbjct: 2455 HALKPFYSLNLSVSD-GV--FRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
Query: 968 SLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLF--RVI 1025
+K++D Y G + + IV D F I + G +F ++LD ET + + R++
Sbjct: 2512 MEVKTTDGDSGIY-GHVTYHIVNDFAKDRFYI-NERGQIFTLEKLDRETPAEKVISVRLM 2569
Query: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DDG 1084
D ++ + +++ + D ND++P F+ +++ + GT V A D D+G
Sbjct: 2570 AKDAGGKVAFCT---VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEG 2626
Query: 1085 SFLNSRIQYYIESHNPGTNPFL-IHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTD 1143
S N+ I Y IE+ + L I+ G + T L V A D N +
Sbjct: 2627 S--NADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVD---NGSP 2681
Query: 1144 RRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYS 1202
+ + + IL P F F V EDV +G+ + I A +G V YS
Sbjct: 2682 SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLYS 2736
Query: 1203 ILSG-----NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA-LDDGTPALSSSQTLT 1256
++ G N + +F++D SG L LD+E + ++LA + +S ++
Sbjct: 2737 LVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVS 2796
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL 1316
+ V D ND +PVF+ YEA + EN G V ++ A D DSG N ++ + + S E+
Sbjct: 2797 IQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEV 2856
Query: 1317 ---FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDENDHAP 1372
F IN +TG + T LD E ++ + ++V+ D G LSST + TV D ND P
Sbjct: 2857 IESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPP 2916
Query: 1373 EFIVSSYDIEVLENQEPEVVYTVLA-SDMDAGN-NRAVEYHIIDGNTDECFTINEMSGE- 1429
F Y V E+ V +L+ +D D+ NR V Y I G+ F + + E
Sbjct: 2917 RFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEW 2976
Query: 1430 -LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR 1488
+ + LDRE+ N+ L I + D SS ++V+VLDAND+SP Y ++
Sbjct: 2977 KVYVKKPLDREKRDNYLLTITAT---DGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIP 3033
Query: 1489 EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548
ED G +++ +SA D D N + Y L + F ++P +G LKTS LDRE ++ +
Sbjct: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVY 3093
Query: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRAD 1608
A D G R I + + DVNDN P +P+ + + + V+A
Sbjct: 3094 HLLVRATD---GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQAT 3150
Query: 1609 DLDLGPNGTVVFSFAET-QSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPAR- 1665
D D G N +++S ++ FSI++ +G IQ ++ E ++ L LK DQG+P R
Sbjct: 3151 DADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRL 3210
Query: 1666 TTTGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIF 1723
T TG +++ ++ D F + Y V+E+ GT ++ V A + D + YSI
Sbjct: 3211 TATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSII 3270
Query: 1724 SGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA---VLIQDE 1780
SGNE G S+ SK+G + + E LD+E +E L V A G + VA V + D
Sbjct: 3271 SGNEHGKFSIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDI 3328
Query: 1781 NDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDAL 1840
NDN+P F Q Y +SE + VI V A D D N I YSI+ GNQ +F ID +
Sbjct: 3329 NDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPV 3388
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEI 1900
G + +LD E S Y+L VQA+D G P NTT + + V+D+NDNAP F I
Sbjct: 3389 RGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVI 3448
Query: 1901 TEDSLP-GVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEE 1957
+++ P G V + V D D N F N F ++ GV++ + +E
Sbjct: 3449 IQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKE 3507
Query: 1958 MTEYELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTL 2014
Y L ++++D+ +L +RV++ + PP +T G + +
Sbjct: 3508 KDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKI 3567
Query: 2015 SATDLESNENISYRILSSSKEFSIDPKNGTIFTIS----PVLLLDTISTTQFL--VEASD 2068
ATD + + ++Y S+DP+ +F++S ++ + Q+L V +D
Sbjct: 3568 HATDQDVYDTLTY---------SLDPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVSVTD 3618
Query: 2069 GGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHD--WTRE 2126
G + +T + I + T+ +L+ + VG F + R
Sbjct: 3619 GKFTTVADIT---VHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRR 3675
Query: 2127 NTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELV 2179
N S+ S S+ + H++ F + Q+ LLH ++ + E++
Sbjct: 3676 NDIQIVSLQS--SEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEII 3726
Score = 499 bits (1286), Expect = e-140
Identities = 542/2110 (25%), Positives = 901/2110 (42%), Gaps = 270/2110 (12%)
Query: 551 TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
TL ++A ++ + +A V V++ + P F Y V + E+ + T + + A
Sbjct: 117 TLIVKALEKNTNVEARTKVRVQVLDTNDLRP--LFSPTSYSVSLPENTAIRTSIARVSAT 174
Query: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF 670
YS + D MF I P +G I L + DY T+ Y + A + G
Sbjct: 175 D-ADIGTNGEFYYSFKDRTD--MFAIHPTSGVIVLTGRLDYLETKLYEMEILA--ADRGM 229
Query: 671 LQNVSTTV------IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
S+ + V + N+ +P + V E P I +T D D G N
Sbjct: 230 KLYGSSGISSMAKLTVHIEQANECAPV-ITAVTLSPSELDRDPAYAI--VTVDDCDQGAN 286
Query: 725 GQLLYFLLSDGKFFKM--NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782
G + + G + + P Y + G
Sbjct: 287 GDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGG------------------------ 322
Query: 783 FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF--- 839
I+W H + +T+ D+G+PP+ + SV I+ P F
Sbjct: 323 ---------IDW----DSHPFGYNLTLQAKDKGTPPQ------FSSVKVIHVTSPQFKAG 363
Query: 840 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGE 899
P ++ E P N V V A + + Y S F ++ N G
Sbjct: 364 PVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTGL 419
Query: 900 IRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPE 959
I + + + V +D+ + V ++V+ + +Q E
Sbjct: 420 ISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDE 474
Query: 960 NLK-PTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTS 1018
N+ T +MSL S+ + NG + +SI A+ F ID TG + S+ LDYE
Sbjct: 475 NVPIGTTVMSL--SAVDPDEGENGYVTYSI-ANLNHVPFAIDHFTGAVSTSENLDYELMP 531
Query: 1019 H-YLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVF 1077
Y R+ +D V +I + + ND++P F+ ++ ++ +G +
Sbjct: 532 RVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 1078 NAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTL------------------VTVSR 1119
+A D D L +QY IE+ N + F ++P+ G L + ++
Sbjct: 592 SAIDADELQL---VQYQIEAGNE-LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA 647
Query: 1120 LDRESIPT---VILTVTASDQAVNV--TDRRLRSLTAQIVIL------------------ 1156
D E+ T + +TV AS + VN+ + + + A+ ++
Sbjct: 648 TDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSH 707
Query: 1157 DVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFML 1214
VN H P F S VKE+ VGS V + + D D G NGK+ Y++ GNE+ FM+
Sbjct: 708 SVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI 767
Query: 1215 DESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLY 1274
D +G+L PLD E ++ L + D G P ++ + L V V+D ND P F Q Y
Sbjct: 768 DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESY 827
Query: 1275 EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDR 1334
V E++ + +VEA D+D G N + + I+ + F I+S TG V LDR
Sbjct: 828 FVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVTGVVNIARPLDR 885
Query: 1335 EIQEVFTLRVLVRDGG--FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEV 1391
E+Q +L++ RD P L ST + ++ED ND+ P FI +Y ++V E+ E V
Sbjct: 886 ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTV 945
Query: 1392 VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCS 1451
+ + A D D G + V Y ++D + + F ++++SG + + LD E+ + L +
Sbjct: 946 IMWLEAHDPDLGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
Query: 1452 DLGDP-PRSSVIHLQVRVLDAND--HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEG 1508
D G P SS +++V V+D N+ H P F + + +V+EDA VG++V+ +SA D+D
Sbjct: 1005 DKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Query: 1509 LNGQTEYFLTDEAS-GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTV 1567
+G+ Y + D + G F I +G ++TS+ LDRE+ S + + A D QG +
Sbjct: 1065 RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD---QGVVPLSS 1121
Query: 1568 IIKVY--VTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF--A 1623
I++Y V DVNDN P + + + SP + + V + A D D N +++
Sbjct: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181
Query: 1624 ETQSMFSIDKYTGEI-----QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIH-MEG 1677
Q FSI TG I + + E+ L++ VTD G P ++T +++ ++
Sbjct: 1182 NPQGFFSIHPKTGLITTTSRKLDREQQDEHI---LEVTVTDNGSPPKSTIARVIVKILDE 1238
Query: 1678 EDVKISFSHHLYKGLVTENCEAGTS-----------IVTVKAFAPDSIQDSMKYSIFSGN 1726
D K F YK + E + I T K P++ + YSI GN
Sbjct: 1239 NDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA---EISYSIEDGN 1295
Query: 1727 EDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSP- 1785
E G + K+G ++ K F E ++ + R + E + P
Sbjct: 1296 EHGKFFIEPKTGVVSSKR-----FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPK 1350
Query: 1786 ------CFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
FE+S + +V ES AH+I V + + G+ + + I GN + F +D
Sbjct: 1351 PSLEPISFEESFFTFTVMESDPV-AHMIGVISVE-PPGIP--LWFDITGGNYDSHFDVDK 1406
Query: 1840 LSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AV 1898
+G I LD E S+Y+L V+ATD L T + ++V D ND+ P F S+ V
Sbjct: 1407 GTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---TQVFIKVIDTNDHRPQFSTSKYEV 1463
Query: 1899 EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGT--KFAIDQNTGVVVLVKTLDFE 1956
I ED+ P + +S D D + I++ +P + KF +D TG + + LD E
Sbjct: 1464 VIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523
Query: 1957 EMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013
+ ++ L + + D V +VV V D ND+ P F+ Y+ V ES VG VL
Sbjct: 1524 AVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQ 1583
Query: 2014 LSATDLESNEN--ISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEAS 2067
++A D + +N + Y I S + F IDP G+I T LD + ++ +V+A+
Sbjct: 1584 VTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKE---LDRSNQAEYDLMVKAT 1640
Query: 2068 DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTREN 2127
D G+P + +T V I + +N +P+FT K Y++ LSE +GS + +
Sbjct: 1641 DKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVT------AHSQ 1694
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
+ V Y I GN+ + F + HS G ++ +LD E + L+I ++
Sbjct: 1695 SSVVYEIKDGNTGDAFDINP---HS-------GTIITQKALDFETLPIYTLIIQGTNMA- 1743
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI-------TVVSANDRDTG 2240
LS+ + + + D NDN P F Y + ES + S + V+ A D D
Sbjct: 1744 -GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKD 1802
Query: 2241 SHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF---SF 2297
S+A ++Y+I+ + +F ++ +TG ++ + LDYE+ + F TVQ D
Sbjct: 1803 SNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYA 1862
Query: 2298 AVVFVSVLDDNDHAPQFMFSSF--SCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
A V V V+D ND P F + S ++P + + ++NA D D+ + +L YSI
Sbjct: 1863 ANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVK--VITVNATDADSSAFSQLIYSITE 1920
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG-----------NKYCLTVQAKDKGD 2404
G+I K +DY+ G ++Y LTV+A D G
Sbjct: 1921 ---------------------GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASD-GR 1958
Query: 2405 ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
V ++++ E FTQD Y + E + + + + + A I+ + Y +
Sbjct: 1959 FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA--IGNPINEPLFYHI 2016
Query: 2465 GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVS 2524
F +++T+G + P + Q D + H P S A V V V
Sbjct: 2017 LNPDRRFKISRTSG-VLSTTGTPFDREQQEAFDVVVEVTEEHKP---SAVAHVVVKVIVE 2072
Query: 2525 FSSEGTPLAV 2534
++ P+ V
Sbjct: 2073 DQNDNAPVFV 2082
Score = 204 bits (519), Expect = 1e-51
Identities = 241/947 (25%), Positives = 388/947 (40%), Gaps = 142/947 (14%)
Query: 1678 EDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFAPDSIQDSMKYSIFSGNEDGV---- 1730
E + F+H Y V EN A T + V + + + ++Y I SG+ + +
Sbjct: 28 EQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAE 86
Query: 1731 ---------LSLCSKSGQLTVKEPKFLDFEVRNEVQLIV--LAESSGHRAYCKVAVLIQD 1779
L + +K G + L+ EV++ LIV L +++ A KV V + D
Sbjct: 87 EYILGDFCFLRIRTKGGNTAI-----LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLD 141
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
ND P F + Y S+ E+ + +V ATD D G NG YS ++ + F I
Sbjct: 142 TNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF--KDRTDMFAIHP 199
Query: 1840 LSGVITTKAILDYELTSSYSLIVQATDKGM-----PRLSNTTVIKVQVTDINDNAPAFL- 1893
SGVI LDY T Y + + A D+GM +S+ + V + N+ AP
Sbjct: 200 TSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA 259
Query: 1894 -----------PSEAVEITEDSLPGV--IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
P+ A+ +D G + +S+ DL F S PG+K
Sbjct: 260 VTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQF---RTVRSFPGSK--- 313
Query: 1941 DQNTGVVVLVKTLDFEEMT-EYELLIQISDSVHYTEGALVVRVLDVND-----NPPVFSQ 1994
V + +D++ Y L +Q D + + V+V+ V P F +
Sbjct: 314 ---EYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFS-SVKVIHVTSPQFKAGPVKFEK 369
Query: 1995 DFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLL 2054
D Y+ + E P V+ + A S+ ++ +FS++ G I + PV
Sbjct: 370 DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPV--- 426
Query: 2055 DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLV 2114
F +E + D +A T V + + N+ PEFT +Y + E+ +G+T++
Sbjct: 427 KRQQAAHFELEVT---TSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
Query: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
+ S +D D EN YV YSI + N HV H G + +LD E
Sbjct: 484 SLSAVDPD-EGENGYVTYSIANLN-----HVPFAIDHF------TGAVSTSENLDYELMP 531
Query: 2175 S-HELVILASDSGCPPLSSTAVI-SIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
+ L I ASD G P V+ +I + ++NDN P F ++ + +G IT V
Sbjct: 532 RVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPL------------------- 2273
SA D D + Y I +GNE F L N+GVL L + L
Sbjct: 592 SAIDADELQLVQ--YQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATD 649
Query: 2274 --DYEKMTKFTLTVQAS----------------------DAEKKHFSFAV--VFVSVLDD 2307
++ +TV AS A K H V +F
Sbjct: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
Query: 2308 NDHAPQFMFSSFSCI-VPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYD 2366
N H PQF + + I V EN P+ S++ +N+ D D G G+L Y++ +
Sbjct: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSG--------GNE 761
Query: 2367 HDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPI 2424
F+ID TG + LD E +KY L + D G A ++ V + ++ P
Sbjct: 762 DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPE 821
Query: 2425 FTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIR 2484
F Q+ YF + E + I +VEA+D D G +G + YS+ T + FS++ G + + R
Sbjct: 822 FLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIAR 881
Query: 2485 ALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
L +L E +L+++ + + F++ V V++ ++ P
Sbjct: 882 PL---DRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
Score = 72.8 bits (177), Expect = 5e-12
Identities = 77/283 (27%), Positives = 114/283 (40%), Gaps = 45/283 (15%)
Query: 2203 VNDNPPNFSSLSYHTHVKESTPLGSHIT-VVSANDRDTGSHAEIIYNIISGNEKGHFYLE 2261
+ P F+ L Y+ V+E++ +++ V T E+ Y I+SG+ + F E
Sbjct: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
Query: 2262 E----------------NTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVL 2305
E NT +L + E +TL V+A + + V V VL
Sbjct: 87 EYILGDFCFLRIRTKGGNTAIL------NREVKDHYTLIVKALEKNTNVEARTKVRVQVL 140
Query: 2306 DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY 2365
D ND P F +S+S +PEN I ++I ++A D D G GE YS
Sbjct: 141 DTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-------- 192
Query: 2366 DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG-------DATASLVVWVDIEGI 2418
D+F I P +G I LDY Y + + A D+G ++ + V IE
Sbjct: 193 --DMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQA 250
Query: 2419 DEFEPIFTQDQYFFTLPEKNKDRQ-LIGRVEASDADAGIDGVI 2460
+E P+ T TL DR V D D G +G I
Sbjct: 251 NECAPVITA----VTLSPSELDRDPAYAIVTVDDCDQGANGDI 289
Score = 54.7 bits (130), Expect = 1e-06
Identities = 56/200 (28%), Positives = 88/200 (44%), Gaps = 13/200 (6%)
Query: 374 PAEFERPKYTFLVYEDVPEDSPIG-TVKAREPL-NSSEPIFYRISSGDLGGKFSIHPR-L 430
P +F +Y V E+ + +G VK + + + + Y+I SGD F L
Sbjct: 31 PLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL 90
Query: 431 GT-----IRTRKP----LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481
G IRT+ L+ E + L V+A + + T+V + V+D ND P F
Sbjct: 91 GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS 150
Query: 482 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGS 541
TS + + + T T++ A D D G NG YS + +FAI GV+ L G
Sbjct: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-KDRTDMFAIHPTSGVIVLTGR 209
Query: 542 LGAGEQRELTLTLRAEDQGV 561
L E + + + A D+G+
Sbjct: 210 LDYLETKLYEMEILAADRGM 229
Score = 47.4 bits (111), Expect = 2e-04
Identities = 27/77 (35%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 216
+ A+ VRV + D ND P+F+P++Y S+ + T T I V ATD D G G Y
Sbjct: 129 VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
Query: 217 IPGNVSSLFTIDSTTGL 233
+ + +F I T+G+
Sbjct: 189 --KDRTDMFAIHPTSGV 203
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 668 bits (1723), Expect = 0.0
Identities = 662/2439 (27%), Positives = 1100/2439 (45%), Gaps = 215/2439 (8%)
Query: 149 HLALVKG---GLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATD 203
+L +VKG G +A+ +V+++ D+ND P+F+P+TY +I++ T T + V ATD
Sbjct: 125 YLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATD 184
Query: 204 QDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS------------PEVEILSAVNFSADKE 251
D G G Y N LF++ T+G+ S ++EIL AV+
Sbjct: 185 ADIGSNGEFYYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEIL-AVDRGMKLY 241
Query: 252 VMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE 311
N + L H +ER E A + F K + + V D A+GE
Sbjct: 242 GNNGVSSTAKLYVH---IERINEHAPTIHVVTHVPFSLEKEPTYA-VVTVDDLDDGANGE 297
Query: 312 AAA-----------RYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGG 353
+ ++A K L E I + + P + +L + A+D G
Sbjct: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY------NLTLQAKDKG 351
Query: 354 GLTAVINADVTIHIFQTT--LAPAEFERPKYTFLVYEDVPEDSPIGTVK-AREPLNSSEP 410
+A ++I T P FE+ Y + E P + VK + EP++
Sbjct: 352 S-PQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID---- 406
Query: 411 IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITV 470
+ Y++S G+ F I+PR G I T +PL+ + V L V + G A +V I++
Sbjct: 407 VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA----QVTISI 462
Query: 471 MDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAID 530
D ND+ P F + + ++++ P GT++ A D+D G NG I YSIAS F I+
Sbjct: 463 EDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVIN 522
Query: 531 RALGVLFLNGSLGAGEQREL-TLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEH 587
+ GV+ L E+ +RA D G ++ + V + ++SP FE
Sbjct: 523 QFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP--LFEK 580
Query: 588 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR 647
+ Q +S + A + ++Y + + F + P +G + L++
Sbjct: 581 VACQGVISYDFPVGGHITAVSAIDIDELEL---VKYKIISGNELGFFYLNPDSGVLQLKK 637
Query: 648 QFDYESTQTYNF--RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK---VE 702
+ NF R+ A DG +N++ + + + + LH + K
Sbjct: 638 SLTNSGIKNGNFALRITA---TDG--ENLADPMSINI--------SVLHGKVSSKSFSCR 684
Query: 703 ESPVPQGVIGKITAIDMDSGK-------------NGQLLYFLLSDGKFFKMNPNTGPAGT 749
E+ V Q + K+ +GK N Q YF S + +
Sbjct: 685 ETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGAN 744
Query: 750 IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTV 809
I I D + F+G SD ++ G+L + +DREH + + +
Sbjct: 745 ILKIKAYDADSGFNGKVLFTISD---GNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNI 801
Query: 810 LVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 869
+ D G+P +++ + ++V D NDN P F Q V +LE + + V A+D
Sbjct: 802 TIYDLGNPQKSSWRLLTINVEDANDNSPVFIQ----DSYSVNILESSGIGTEIIQVEARD 857
Query: 870 PDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ 929
D G+N EVTYSV ++ + F I+++ G + L + + +Y + + A D+ Q
Sbjct: 858 KDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQ 915
Query: 930 GQAVVNIQVI-----PLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL 984
+VV ++V S S +++ L E+L +++ +++ D G++
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVL---EDLPVGTVIAWLETHDP-DLGLGGQV 971
Query: 985 HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSID 1044
+S+V +D +G FEID ++G + LSKELDYE Y V D + +SLSS F+ ++
Sbjct: 972 RYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Query: 1045 VEDQND--HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
V D N+ H+P F D +V SV+EN IGT V A+D+D S + IQY I G
Sbjct: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDED-SGRDGEIQYSIRD-GSGL 1088
Query: 1103 NPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHN 1162
F I G + LDRE++ + LTV A+D+ V ++ I + DVND+
Sbjct: 1089 GRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL---YSTIEVYIEVEDVNDNA 1145
Query: 1163 PTF---ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG 1219
P I +P V E+ V I A DPD N K+TY I SGN F ++ +G
Sbjct: 1146 PLTSEPIYYP--VVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203
Query: 1220 LLTTTC-PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
L+TTT LD E + +H L V D G S+ + V VLD ND P F + +Y+ +
Sbjct: 1204 LITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKL 1263
Query: 1279 --KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREI 1336
++ + GE + R A DRD G N+++ + I+ G F I+ TG V +
Sbjct: 1264 PERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGS 1323
Query: 1337 QEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL 1396
++ T++ + D G P SST + +E P I ++D EP +TV+
Sbjct: 1324 YDILTIKAV--DNGRPQKSSTARL--HIEWIKKPPPSPIPLTFD-------EPFYNFTVM 1372
Query: 1397 ASDMDA---------GNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLV 1447
SD N + + I+ GN D F + G + + LD EQ S + +
Sbjct: 1373 ESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMS 1432
Query: 1448 ILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDE 1507
+ ++ D +V + ++VLD ND+ P F Y ++ ED T +L + A D+DE
Sbjct: 1433 V---EVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
Query: 1508 --GLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRST 1565
L+ + + F IDP +G L T+ LD EA+ +H + + RD R+
Sbjct: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNL 1549
Query: 1566 TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF--A 1623
+I V V D ND+ P ++ + + + V A D D G N ++++
Sbjct: 1550 ARVI-VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAG 1608
Query: 1624 ETQSMFSIDKYTGEIQFQQNPS-SEYFPIWLQLKVTDQGIPARTTTGLLVIHME-GEDVK 1681
T +MF I+ G I + P + L +KVTDQG P + T ++ I + ++
Sbjct: 1609 NTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668
Query: 1682 ISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLT 1741
F H Y+ V EN + GTS++ + A + Q ++ Y + G+ +G+ ++ SG +T
Sbjct: 1669 PKFIHKDYQAEVNENVDIGTSVILISAIS----QSTLIYEVKDGDINGIFTINPYSGVIT 1724
Query: 1742 VKEPKFLDFEVRNEVQLIVLAES-SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800
+ K LD+E + QLI+ A + +G + V + I DENDN+P F S Y S+SE+
Sbjct: 1725 TQ--KALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAA 1782
Query: 1801 LYNAHV-------IQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYE 1853
N+ V + + ATD DS N L+ Y I+ ++ F +D+ +G I T A LD+E
Sbjct: 1783 PINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHE 1842
Query: 1854 LTSSYSLIVQATDKGMPRLS--NTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP---GV 1908
+ + V D G P+L+ + + ++VTD+NDN P F ++AV T LP GV
Sbjct: 1843 TIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVF--TQAVFETILLLPTYVGV 1900
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQIS 1968
V VS D D +++ F ID N+GV+ +K + + Y L++++S
Sbjct: 1901 EVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLT-IKNNNLSK-DHYMLIVKVS 1958
Query: 1969 DSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR 2028
D Y+ + + V + D+ F+Q FY ++ E+ V ++A NE + Y
Sbjct: 1959 DGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYS 2018
Query: 2029 ILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMN 2088
IL+ +F I +G I T + + +VEAS + A +V + IED+N
Sbjct: 2019 ILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDIN 2078
Query: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETK 2148
+ +P F Y ++ DA G+ + + ID D N + + ++
Sbjct: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKD------------KGPNGEVTYVLQDD 2126
Query: 2149 FFHSEYPYKQVGYLVLLHSLDREAS-ASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
+ H E G ++L + + + S + + ILA D G P LS++ + I + VN
Sbjct: 2127 YGHFEI-NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAM 2183
Query: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVL 2267
P F Y V E + + I ++A + IIY II G+ F ++ +TGVL
Sbjct: 2184 PVFDKPFYTASVNEDIRMNTPILSINATSPEGQG---IIYIIIDGDPFKQFNIDFDTGVL 2240
Query: 2268 YLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENL 2327
++ PLDYE + + LT++ASDA + V + V D ND+ P F +++ + E
Sbjct: 2241 KVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEAS 2300
Query: 2328 PISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDY 2387
I + + + ++D D+ + Y IV + D F ID +G I ++LD+
Sbjct: 2301 LIGTPVLQVVSIDADSENNKMVHYQIVQDTY------NSTDYFHIDSSSGLILTARMLDH 2354
Query: 2388 ENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIG 2445
E L V++ D G ++ ++V + I +++ P+F Q Y + E +
Sbjct: 2355 ELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVT 2414
Query: 2446 RVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
V+ASDAD+ + YS+ G F ++ +G I L
Sbjct: 2415 CVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITL 2453
Score = 627 bits (1617), Expect = e-179
Identities = 660/2512 (26%), Positives = 1081/2512 (43%), Gaps = 283/2512 (11%)
Query: 79 VTASDADSGLYGFIE-YSLYDG------FLSYEAPQAFRIDPHDGQICVSQDIDRERDPA 131
VT D D G G IE S+ G FL+ E ++ +I + ID E P
Sbjct: 285 VTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWL-----NEYKIKERKQIDWESFPY 339
Query: 132 TYDLLVEAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPV-FNPSTYVTSISDE 189
Y+L ++AKD G Q+ + L V G D P+ F Y SIS+
Sbjct: 340 GYNLTLQAKDKGSPQKCSALKAVYIG-----------NPTRDTVPIRFEKEVYDVSISEF 388
Query: 190 TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLY---------SPEVEI 240
+ PG + V + + V Y+L PG + F I+ +GL EV
Sbjct: 389 SPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYK 444
Query: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
L N D + ++ + E+A + E + + +
Sbjct: 445 LEVTNKEGDLKAQVTISI--------------EDANDHTPEFQQPLYDAYVNESVPVGTS 490
Query: 301 VQDEAASADGEAAARYVANLAKILG---------EGIIYLTLPLSHLESTTL-SLMVSAQ 350
V +AS + Y+ L G+I T L S + +V A
Sbjct: 491 VLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRAS 550
Query: 351 DGGG-LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
D G +VTI I FE+ ++ D P I V A + ++ E
Sbjct: 551 DWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAID-IDELE 609
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH---------------------ETQPVVV 448
+ Y+I SG+ G F ++P G ++ +K L + + + +
Sbjct: 610 LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINI 669
Query: 449 LTVQAQLGSAP-ACSSTEVN-----------------------ITVMDVNDNHPAFLRT- 483
+ ++ S +C T V + +N P F ++
Sbjct: 670 SVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSF 729
Query: 484 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSL 542
++ + + P G + +A D DSG NG + ++I+ F ID G L + +
Sbjct: 730 PSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPM 789
Query: 543 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPM 601
L + D G +++ +LT+ +E ++SP F Y V + ES
Sbjct: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSP--VFIQDSYSVNILESSGIG 847
Query: 602 TQMLQTQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 659
T+++Q +A LG + YS+ D+ F I TG +Y+ Q D ES Y+
Sbjct: 848 TEIIQVEARDKDLGSN---GEVTYSV--LTDTQQFAINSSTGIVYVADQLDRESKANYSL 902
Query: 660 RVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718
++ A + Q S T+ V + D ND SP F+ +KV E VI + D
Sbjct: 903 KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHD 962
Query: 719 MDSGKNGQLLYFLLSD--GKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D G GQ+ Y L++D G+F I A GA S
Sbjct: 963 PDLGLGGQVRYSLVNDYNGRF--------------EIDKASGAIRLSKE----------- 997
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA-VYVSVTDINDN 835
LD E + + +TV D+G P ++++ V V V D+N+N
Sbjct: 998 --------------------LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN 1037
Query: 836 --RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
P+FP + V E + V V A+D D G + E+ YS+ F I
Sbjct: 1038 LHTPYFPDFA----VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSI 1093
Query: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIR 953
D +G I IL + SY ++V ATD+GV PL V I+V ++ + S+ I
Sbjct: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDL-FLSKEL 1012
+ ++ EN P + + ++ N KL + I + + F I+ TG + S++L
Sbjct: 1154 YPVVMEN-SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Query: 1013 DYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEE--NVPI 1070
D E + + V TD + ST+++ + V D+ND+ P F +++ I + E
Sbjct: 1213 DREQQAEHFLEVTVTDGGPS-PKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKR 1271
Query: 1071 GTLVY-VFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
G +Y F D+G N+ I Y I N F I P G + + + S I
Sbjct: 1272 GEPIYRAFAFDRDEGP--NAEISYSIVDGN-DDGKFFIDPKTGMVSSRKQFTAGSYD--I 1326
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI------SFPNAHVKEDVTVGSLV 1183
LT+ A D R +S TA++ I + P+ I F N V E V +V
Sbjct: 1327 LTIKAVDNG-----RPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV 1381
Query: 1184 HHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD 1243
++ + N + + I+ GN + F ++ G + PLD E ++ + ++V D
Sbjct: 1382 GVVSV----QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD 1437
Query: 1244 DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSK 1303
A++ + + VLD ND P F Q Y+ ++ E+ P + ++EA DRD K
Sbjct: 1438 GTNVAVTQ---VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHK 1492
Query: 1304 LQFEI---MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
L + + + S F I+ TG + T LD E Q+ L ++VRD FP + +
Sbjct: 1493 LSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARV 1552
Query: 1361 LCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDE 1419
+ VED NDH+P F Y+ V E+ V V A D D G N + Y I GNT
Sbjct: 1553 IVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN 1612
Query: 1420 CFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFP 1479
F I + G ++ + D + F L I +D G PP S+ +++ V +++ P F
Sbjct: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFI 1672
Query: 1480 TLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSN 1538
YQ+ V E+ ++GT V+++SA+ + + Y + D + +G FTI+P SG + T
Sbjct: 1673 HKDYQAEVNENVDIGTSVILISAISQSTLI-----YEVKDGDINGIFTINPYSGVITTQK 1727
Query: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPT 1598
LD E S + A + + S +T + + + D NDN PV + + LS +P
Sbjct: 1728 ALDYERTSSYQLIIQATNMAGMASNAT---VNIQIVDENDNAPVFLFSQYSGSLSEAAPI 1784
Query: 1599 N-------QTTVIVRADDLDLGPNGTVVFSFAET--QSMFSIDKYTGEIQFQQNPSSEYF 1649
N + +++RA D D N +V+ E+ + F++D TG I+ N E
Sbjct: 1785 NSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETI 1844
Query: 1650 P-IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTSIVT 1705
+ V D G P T + +++E DV + F+ +++ ++ G ++
Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904
Query: 1706 VKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES 1764
V A PDS + + YS+ G+ D L + S SG LT+K ++ LIV
Sbjct: 1905 VSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVLTIKNNNL----SKDHYMLIVKVSD 1959
Query: 1765 SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQV-FATDLDSGLNGLIE 1823
+ V +++++ D+ F QS Y S+SE+ N ++ +V + + LN ++
Sbjct: 1960 GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRLNEPLK 2016
Query: 1824 YSILSGNQEEAFQIDALSGVITTKAI-LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQV 1882
YSIL N F+I + SGVI T + D E Y L+V+A+ + V++V +
Sbjct: 2017 YSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNI 2074
Query: 1883 TDINDNAPAF--LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
DINDN+P F LP A + D+ PG ++ V+ D D ++ + + G F I
Sbjct: 2075 EDINDNSPVFVGLPYYAA-VQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYG-HFEI 2132
Query: 1941 DQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDFYQ 1998
+ N+G V+L + + + EY + I D + V + + VN PVF + FY
Sbjct: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYT 2192
Query: 1999 VTVPESIPVGYSVLTLSATDLESNENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDT 2056
+V E I + +L+++AT E + I Y I+ K+F+ID G + +SP L +
Sbjct: 2193 ASVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSP-LDYEV 2250
Query: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116
S + + ASD RA V++ + D+N+ P F +YN +LSE +L+G+ ++
Sbjct: 2251 TSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQV 2309
Query: 2117 SNIDHDWTRENTYVEYSIISG--NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
+ID D + N V Y I+ NS + FH+++ G ++ LD E
Sbjct: 2310 VSIDAD-SENNKMVHYQIVQDTYNSTDYFHIDS----------SSGLILTARMLDHELVQ 2358
Query: 2175 SHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSA 2234
L + + DSG P LSS ++ I + DVNDNPP F+ L Y ++V E P G +T V A
Sbjct: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418
Query: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKH 2294
+D D+ + Y+I+SGN++ F ++ +GV+ L ++L V SD
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG--LF 2476
Query: 2295 FSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIV 2354
S A V + VL N ++P F S++ V EN+ + + + A D D G YG+++Y+I+
Sbjct: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536
Query: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN--GNKYCLTVQAKDKGDATASLVVW 2412
+ + D FLID G + + LD EN + V+A D G T V
Sbjct: 2537 N--------DFAKDRFLIDS-NGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVR 2587
Query: 2413 VDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
V + ++ P F +Y ++ L+ +V+A D D G + I YSL
Sbjct: 2588 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSL 2639
Score = 595 bits (1533), Expect = e-169
Identities = 680/2503 (27%), Positives = 1070/2503 (42%), Gaps = 252/2503 (10%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++ A DADSG G + +++ DG F ID GQ+ V +DRE Y L +
Sbjct: 747 KIKAYDADSGFNGKVLFTISDG----NTDSCFNIDMETGQLKVLMPMDREHTDL-YLLNI 801
Query: 138 EAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
D G+ Q+ S+ + +++ED NDN PVF +Y +I + + GTEI
Sbjct: 802 TIYDLGNPQK-----------SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI 850
Query: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVEILSAVNFSADKEVMN 254
I V A D+D G G V Y ++ + F I+S+TG+ + +++ S N+S E +
Sbjct: 851 IQVEARDKDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908
Query: 255 SLEMFLPL-----LRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD 309
E L L+ F D A S + +L+ D
Sbjct: 909 KAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968
Query: 310 GEA----AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAVINAD 362
G+ Y G I L+ L + + +L V A+D G L++V +
Sbjct: 969 GQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
Query: 363 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAR-EPLNSSEPIFYRISS 417
V + L F F V V E+S IGT V AR E I Y I
Sbjct: 1029 VEVVDVNENLHTPYFP----DFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
Query: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 476
G G+FSI G I LD ET LTV A G P S+ EV I V DVNDN
Sbjct: 1085 GSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDN 1144
Query: 477 HPAFLRTSDEIR---ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 532
P TS+ I + + +P ++ +AED DS N + Y I S P FAI+
Sbjct: 1145 APL---TSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIK 1201
Query: 533 LGVLFLNG-SLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVY 590
G++ L +Q E L + D G P Q+ + V+ V+++ ++ P F VY
Sbjct: 1202 TGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ--FPEKVY 1259
Query: 591 QVEVSESLSPMTQMLQTQAHPL----------GPQRAASPLRYSLEPSVDSAMFGIRPYT 640
Q+++ E + + + P+ GP + + YS+ D F I P T
Sbjct: 1260 QIKLPE------RDRKKRGEPIYRAFAFDRDEGPN---AEISYSIVDGNDDGKFFIDPKT 1310
Query: 641 GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSP---TFLHDV 696
G + R+QF S + ++G Q ST + W + SP TF
Sbjct: 1311 GMVSSRKQFTAGSYDILTIKAV----DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
Query: 697 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
V ES ++G ++ ++ L+F + G F
Sbjct: 1367 YNFTVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNF------------------- 1402
Query: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
D AF + E G G ++ LD E R + M+V VTD +
Sbjct: 1403 ---------DSAFDA-------------EKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 817 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 876
A V++ V D NDN P F Q V + E + + + A D DE +
Sbjct: 1441 V---AVTQVFIKVLDNNDNGPEFSQ----PNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
Query: 877 EVTYSVSSED-SSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVN 935
T S + S F+ID + G + T L ++ + + ++++ DQ P + A V
Sbjct: 1494 SYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
Query: 936 IQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG 995
+ V + + + + E+ + + + D + N +L ++I A +
Sbjct: 1554 VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDK-DKGENAELIYTIEAGNTGN 1612
Query: 996 HFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
F+I+ G + + KE D T ++ + TD + +S+T + I V ++ P F
Sbjct: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG-SPPMSATAIVRISVTMSDNSHPKF 1671
Query: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLV 1115
+ V ENV IGT V + +A ++ Y F I+P G +
Sbjct: 1672 IHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDINGIFTINPYSGVIT 1724
Query: 1116 TVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVK 1174
T LD E + L + A++ A + + T I I+D ND+ P F+ S + +
Sbjct: 1725 TQKALDYERTSSYQLIIQATNMAGMAS-----NATVNIQIVDENDNAPVFLFSQYSGSLS 1779
Query: 1175 EDVTVGSLVHH-------ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPL 1227
E + S+V I A D D RN + Y I+ F +D S+G + T L
Sbjct: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
Query: 1228 DYEMKTQHILTVLALDDGTPALSSSQTLTVT--VLDVNDEAPVFKQHLYEASVKENQNPG 1285
D+E V D G+P L++ + V V DVND PVF Q ++E + G
Sbjct: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVG 1899
Query: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
V +V A D DS V +L + +M G S + F I+S++G V T + ++ + L V
Sbjct: 1900 VEVLKVSATDPDSEVPPELTYSLMEG-SLDHFLIDSNSG--VLTIKNNNLSKDHYMLIVK 1956
Query: 1346 VRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNN 1405
V DG F S S T + V++ D F S Y + EN + + + + N
Sbjct: 1957 VSDGKFYSTSMVTIM---VKEAMDSGLHFTQSFYSTSISEN-NTNITKVAIVNAVGNRLN 2012
Query: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRA-LDREQISNFTLVILCSDLGDPPRSSVIHL 1464
++Y I+ N F I SG + TT DRE+ + LV+ S D R + + +
Sbjct: 2013 EPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVV 2070
Query: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA 1524
+V + D ND+SP F L Y ++V+ DAE GT++ ++A+DKD+G NG+ Y L D+ G
Sbjct: 2071 RVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD-YGH 2129
Query: 1525 FTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVL 1583
F I+P SG + + + + ++ + +A+D G S + +++ +T VN PV
Sbjct: 2130 FEINPNSGNVILKEAFNSDLSNIEYGVTILAKD---GGKPSLSTSVELPITIVNKAMPVF 2186
Query: 1584 EQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQN 1643
++ + ++ + N + + A + G + + F+ID TG ++
Sbjct: 2187 DKPFYTASVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSP 2245
Query: 1644 PSSEYFPIW-LQLKVTD--QGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG 1700
E + L ++ +D G A T LLV + D F Y ++E G
Sbjct: 2246 LDYEVTSAYKLTIRASDALTGARAEVTVDLLV--NDVNDNPPIFDQPTYNTTLSEASLIG 2303
Query: 1701 TSIVTVKAFAPDSIQDSM-KYSIFSG--NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQ 1757
T ++ V + DS + M Y I N + S SG + + LD E+
Sbjct: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG--LILTARMLDHELVQHCT 2361
Query: 1758 LIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
L V + SG + V + I D NDN P F Q IY++ VSE V V A+D
Sbjct: 2362 LKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDA 2421
Query: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
DS +EYSILSGN +F +D+ SGVIT + YSL V +D G+ ++
Sbjct: 2422 DSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-GL--FTS 2478
Query: 1875 TTVIKVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVD------LNSAFIFS 1927
T + ++V N +PAF S V E+ E+ G V HV D D ++ A I
Sbjct: 2479 TAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIND 2538
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLI---QISDSVHYTEGALVVRVLD 1984
FAK+ +F ID N G V+ + LD E E ++ I + T + V V+D
Sbjct: 2539 FAKD-----RFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVD 2592
Query: 1985 VNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKE-----FS 2037
NDN P F Y+ +V + G+ V + A D + +N I+Y + S +
Sbjct: 2593 ENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLE 2652
Query: 2038 IDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK 2097
IDP NG + T L + F V+A DGG P +L V I + + P FT
Sbjct: 2653 IDPDNGWMVTKGNFNQLKN-TVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711
Query: 2098 SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN-----FHVETKFFHS 2152
Y+ +++ED +GST+ T + + V +S ++G N F +E
Sbjct: 2712 QYSFTIAEDTAIGSTVDTLRIL------PSQNVWFSTVNGERPENNKGGIFVIE------ 2759
Query: 2153 EYPYKQVGYLVLLHSLDREAS-ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFS 2211
++ G + L LDRE S A H V + T + I+VLD+NDN P F
Sbjct: 2760 ----QETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
Query: 2212 SLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGH----FYLEENTGVL 2267
+ SY T + E P+G+ +T V A D D G++ ++ Y++ S ++ F ++ NTG +
Sbjct: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
Query: 2268 YLIKPLDYEKMTKFTLTVQASDAEKKH--FSFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325
+K LD+E FT +V ASD + S A+V V V D ND+AP F + V E
Sbjct: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
Query: 2326 NLPISSTICSINALDFDAGPYG-ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI 2384
+ P + ++ D D +++Y I T G + ++ K+
Sbjct: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHI------TGGNPRGRFALGLVQSEWKVYVKRP 2989
Query: 2385 LDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLI 2444
LD E + Y L + A D G +V V + +++ P+ Q Y LPE ++I
Sbjct: 2990 LDREEQDIYFLNITATD-GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
Query: 2445 GRVEASDADAGIDGVILYSL-GTSSPFFSVNKTNGNIYLIRAL 2486
+V A DAD G +G I YSL G+ + F ++ +G + + L
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALL 3091
Score = 556 bits (1434), Expect = e-158
Identities = 593/2248 (26%), Positives = 1005/2248 (44%), Gaps = 194/2248 (8%)
Query: 364 TIHIFQTTLAPAEFER-PKYTFLVYEDVPEDSPIGTVK-----AREPLNSSEPIFYRISS 417
TIH+ T P E+ P Y + +D+ +D G ++ A +PL+ F+
Sbjct: 265 TIHV--VTHVPFSLEKEPTYAVVTVDDL-DDGANGEIESVSIVAGDPLDQ----FFLAKE 317
Query: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVV-LTVQAQ-LGSAPACSSTEVNITVMDVND 475
G ++ I + RK +D E+ P LT+QA+ GS CS+ + D
Sbjct: 318 GKWLNEYKI-------KERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRD 370
Query: 476 NHPA-FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRAL 533
P F + ++ IS+ +PPG + + + + Y ++ + V F I+
Sbjct: 371 TVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRS 426
Query: 534 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQV 592
G++ L ++ L + ++ + Q +T+ IE +H+P F+ +Y
Sbjct: 427 GLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPE--FQQPLYDA 479
Query: 593 EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE 652
V+ES+ T +L A + YS+ S++ F I +TG I + D+E
Sbjct: 480 YVNESVPVGTSVLTVSASDKDKGENGY-ITYSIA-SLNLLPFVINQFTGVISTTEELDFE 537
Query: 653 ST-QTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI 711
S+ + Y F V A + V +R+ + NDNSP F E QGVI
Sbjct: 538 SSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLF----------EKVACQGVI 587
Query: 712 -------GKITAIDMDSGKNGQLLYFLLSDGK---FFKMNPNTG-----PAGTIYVITWA 756
G ITA+ +L+ + + G FF +NP++G + T I
Sbjct: 588 SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNG 647
Query: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMT--VLVTDR 814
+ A + TD +D + S+ + G++ + RE R ++ +L+ +
Sbjct: 648 NFALRITATDGENLADPM------SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAK 701
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
+ N ++ IN P+F + P V V E PV + + A D D G
Sbjct: 702 ANGKLNLEDG-FLDFYSINRQGPYFDKSFPSD---VAVKEDLPVGANILKIKAYDADSGF 757
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
N +V +++S ++ F ID G+++ + ++ Y +++ D G P ++
Sbjct: 758 NGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLL 817
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLK-PTKIMSLIKSSDHLQQHYNGKLHFSIVADDK 993
I V + + Q+ + I E+ T+I+ + L NG++ +S++ D +
Sbjct: 818 TINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ 875
Query: 994 DGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN-LSLSSTVFLSIDVEDQNDHS 1052
F I+SSTG ++++ +LD E+ ++Y ++ D +++ L S V L + ++D ND S
Sbjct: 876 Q--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCS 933
Query: 1053 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
P+F + V E++P+GT++ D D L +++Y + + G F I + G
Sbjct: 934 PAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG-LGGQVRYSLVNDYNGR--FEIDKASG 990
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA- 1171
+ LD E LTV A D+ V+ + + ++V ++ N H P F F
Sbjct: 991 AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
Query: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEM 1231
VKE+ +G+ V +TA D D GR+G++ YSI G+ F +D+ SG++T LD E
Sbjct: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
Query: 1232 KTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRV 1291
+ LTV A D G L S+ + + V DVND AP+ + +Y V EN V ++
Sbjct: 1111 MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Query: 1292 EALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT-ILDREIQEVFTLRVLVRDGG 1350
+A D DS N KL + I G F IN TG + TT+ LDRE Q L V V DGG
Sbjct: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE---NQEPEVVYTVLASDMDAGNNRA 1407
ST ++ V DEND+ P+F Y I++ E + E +Y A D D G N
Sbjct: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
Query: 1408 VEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVR 1467
+ Y I+DGN D F I+ +G +S+ + S L I D G P +SS L +
Sbjct: 1291 ISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAG--SYDILTIKAVDNGRPQKSSTARLHIE 1348
Query: 1468 VLDANDHSP---SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA 1524
+ SP +F +Y +V E V +V V+S + L + A
Sbjct: 1349 WIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFD---IVGGNFDSA 1405
Query: 1525 FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
F + GT+ + LD E RS + S D G+ + + V D NDN P
Sbjct: 1406 FDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD----GTNVAVTQVFIKVLDNNDNGPEFS 1461
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPN-GTVVFSFAETQSM--FSIDKYTGEIQFQ 1641
Q +DV +S + + + + A D D V S ++ SM F ID TG +
Sbjct: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Query: 1642 QNPSSE-YFPIWLQLKVTDQGIPARTTTGLLVIHME-GEDVKISFSHHLYKGLVTENCEA 1699
+ E L + V DQ P R +++++E D F++ LY+ V E+
Sbjct: 1522 ERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAAL 1581
Query: 1700 GTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTV-KEPKFLDFEVRNEVQ 1757
G++++ V A D +++ + Y+I +GN + + G +T+ KEP D +
Sbjct: 1582 GSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEP---DMTTMGQFV 1638
Query: 1758 LIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
L + G A V + + +++ P F YQA V+E+ VI + A
Sbjct: 1639 LSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS- 1697
Query: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
+ Y + G+ F I+ SGVITT+ LDYE TSSY LI+QAT+ M +++
Sbjct: 1698 ----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMAS 1751
Query: 1875 TTVIKVQVTDINDNAPAFLPSEAVEITEDSLP----------GVIVTHVSVHDVDLNSAF 1924
+ +Q+ D NDNAP FL S+ ++ P +V + D + N+
Sbjct: 1752 NATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALL 1811
Query: 1925 IFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-----VHYTEGALV 1979
++ ES F +D +TG + + LD E + + + + DS + +
Sbjct: 1812 VYQIV-ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVN 1870
Query: 1980 VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN--ENISYRILSSSKE-F 2036
+ V DVNDNPPVF+Q ++ + VG VL +SATD +S ++Y ++ S + F
Sbjct: 1871 IEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHF 1930
Query: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTV 2096
ID +G + + L D +V+ SDG + ++V I +++ + FT
Sbjct: 1931 LIDSNSGVLTIKNNNLSKDHY---MLIVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQ 1984
Query: 2097 KSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Y+ S+SE+ + + + ++ R N ++YSI+ N N F +++ +
Sbjct: 1985 SFYSTSISEN---NTNITKVAIVNAVGNRLNEPLKYSIL--NPGNKFKIKS----TSGVI 2035
Query: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
+ G DRE +ELV+ AS + V+ + + D+NDN P F L Y+
Sbjct: 2036 QTTGV-----PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYY 2090
Query: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
V+ G+ I V+A D+D G + E+ Y + ++ GHF + N+G + L + + +
Sbjct: 2091 AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNVILKEAFNSD 2148
Query: 2277 -KMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICS 2335
++ +T+ A D K S +V + + N P F ++ V E++ +++ I S
Sbjct: 2149 LSNIEYGVTILAKDGGKPSLSTSVE-LPITIVNKAMPVFDKPFYTASVNEDIRMNTPILS 2207
Query: 2336 INALDFDAGPYGE-LTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
INA P G+ + Y I+ G + F ID TG + LDYE + Y
Sbjct: 2208 INA----TSPEGQGIIYIIID------GDPFKQ--FNIDFDTGVLKVVSPLDYEVTSAYK 2255
Query: 2395 LTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
LT++A D A A + V + + +++ PIF Q Y TL E + + +V + DAD
Sbjct: 2256 LTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDAD 2315
Query: 2454 AGIDGVILYSL----GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPK 2509
+ + ++ Y + S+ +F ++ ++G LI ++ +L + TL+++ I
Sbjct: 2316 SENNKMVHYQIVQDTYNSTDYFHIDSSSG---LILTARMLDHELVQHCTLKVRSI----- 2367
Query: 2510 SDSKFASCT--VFVNVSFSSEGTPLAVF 2535
DS F S + V V++ S VF
Sbjct: 2368 -DSGFPSLSSEVLVHIYISDVNDNPPVF 2394
Score = 516 bits (1330), Expect = e-146
Identities = 585/2199 (26%), Positives = 950/2199 (43%), Gaps = 245/2199 (11%)
Query: 405 LNSSEPIFYRISSGDLGGKFSIHPRLGT------IRTRKP----LDHETQPVVVLTVQAQ 454
++ S I YRI SGD G F + IRT+ L+ E Q +L V+
Sbjct: 73 IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132
Query: 455 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 514
+ + T+VNI V+D+ND P F T+ + I+++TP T++ A D D G NG
Sbjct: 133 VRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGE 192
Query: 515 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV-----HPQAALLV 569
Y + + +F++ GV+ L+G L E+ L + A D+G+ + ++
Sbjct: 193 FYYYFKN-KVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251
Query: 570 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
L V IE+ EH+P+ H+V V S P ++ G +
Sbjct: 252 LYVHIERINEHAPT---IHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308
Query: 629 VDSAMFGIRPYTGW-----IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
+D F + W I R+Q D+ES Y + + + G Q S V +
Sbjct: 309 LD--QFFLAKEGKWLNEYKIKERKQIDWESF-PYGYNLTLQAKDKGSPQKCSALKAVYIG 365
Query: 684 D-ENDNSP-TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFK 739
+ D P F +V + + E P G + AI S + + Y L D +FK
Sbjct: 366 NPTRDTVPIRFEKEVYDVSISEFSPP----GVVVAIVKLSPEPIDVEYKLSPGEDAVYFK 421
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
+NP +G ++T A L ++ E+ + E+ N
Sbjct: 422 INPRSG-----LIVT---------------------ARPLNTVKKEVYKLEVTN------ 449
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
G T+++ D ND+ P F Q L V E PV
Sbjct: 450 -------------KEGDLKAQVTISI----EDANDHTPEFQQPL----YDAYVNESVPVG 488
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS-YRMSV 918
V TV A D D+G N +TYS++S + F I+ G I TT L ++ P YR V
Sbjct: 489 TSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIV 547
Query: 919 IATDQGVPPLQGQAVVNIQV--------IPLSKGRAIMSQNIRHLIIPENLKPTKIMSLI 970
A+D G P + ++ VN+ + PL + + Q + P T + ++
Sbjct: 548 RASDWG-SPYRHESEVNVTIRIGNVNDNSPLFE--KVACQGVISYDFPVGGHITAVSAI- 603
Query: 971 KSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE--TTSHYLFRVITTD 1028
D L+ + + I++ ++ G F ++ +G L L K L ++ R+ TD
Sbjct: 604 -DIDELE-----LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATD 657
Query: 1029 HSKNLSLSSTVFLSI------------------------------------------DVE 1046
+NL+ ++ +S+ D
Sbjct: 658 -GENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFY 716
Query: 1047 DQNDHSPSFQDEL-IVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPF 1105
N P F ++V+E++P+G + A D D F N ++ + I N + F
Sbjct: 717 SINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGF-NGKVLFTISDGNT-DSCF 774
Query: 1106 LIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF 1165
I G L + +DRE +L +T D N R LT I + D ND++P F
Sbjct: 775 NIDMETGQLKVLMPMDREHTDLYLLNITIYDLG-NPQKSSWRLLT--INVEDANDNSPVF 831
Query: 1166 ISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224
I + ++ E +G+ + + A D D G NG+VTYS+L+ + F ++ S+G++
Sbjct: 832 IQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT--DTQQFAINSSTGIVYVA 889
Query: 1225 CPLDYEMKTQHILTVLALD--DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQ 1282
LD E K + L + A D + L S TL V + DVND +P F Y V E+
Sbjct: 890 DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDL 949
Query: 1283 NPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTL 1342
G + +E D D G+ ++++ ++ + FEI+ +G + + LD E Q+ + L
Sbjct: 950 PVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNL 1008
Query: 1343 RVLVRDGGFP-SLSSTTTILCTVED--ENDHAPEFIVSSYDIEVLENQE-PEVVYTVLAS 1398
V +D G P SLSS + + V D EN H P F + V EN V V A
Sbjct: 1009 TVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR 1068
Query: 1399 DMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPR 1458
D D+G + ++Y I DG+ F+I++ SG ++ LDRE + ++ L + +D G P
Sbjct: 1069 DEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Query: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518
S I + + V D ND++P Y V E++ V+ + A D D N + Y +T
Sbjct: 1129 YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188
Query: 1519 D-EASGAFTIDPMSGTL-KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
F I+ +G + TS LDRE +++H D + +T+ + V V D
Sbjct: 1189 SGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG-PSPKQSTIWVVVQVLDE 1247
Query: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVR--ADDLDLGPNGTVVFSFAE--TQSMFSID 1632
NDN P + + + L + I R A D D GPN + +S + F ID
Sbjct: 1248 NDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFID 1307
Query: 1633 KYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM----EGEDVKISFSHHL 1688
TG + ++ ++ + I L +K D G P +++T L I + ++F
Sbjct: 1308 PKTGMVSSRKQFTAGSYDI-LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
Query: 1689 YKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFL 1748
Y V E+ + T IV V + P + + I GN D G + + +P L
Sbjct: 1367 YNFTVMES-DRVTEIVGVVSVQP--ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP--L 1421
Query: 1749 DFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
D E R+ + V + A +V + + D NDN P F Q Y ++SE L + ++Q
Sbjct: 1422 DAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
Query: 1809 VFATDLDS--GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD 1866
+ ATD D L+ + SI S + + F+ID +GV+ T LD+E + L + D
Sbjct: 1482 IEATDRDEKHKLSYTVHSSIDSISMRK-FRIDPSTGVLYTAERLDHEAQDKHILNIMVRD 1540
Query: 1867 KGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDL--NSA 1923
+ P N + V V D ND++P F P + E + G V V+ D D N+
Sbjct: 1541 QEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAE 1600
Query: 1924 FIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--SVHYTEGALVVR 1981
I++ + N G F I+ G++ + K D M ++ L I+++D S + A+V
Sbjct: 1601 LIYTI-EAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
Query: 1982 VLDVNDNP-PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSI 2038
+ ++DN P F YQ V E++ +G SV+ +SA S + Y + F+I
Sbjct: 1660 SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKDGDINGIFTI 1716
Query: 2039 DPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKS 2098
+P +G I T L + S+ Q +++A++ + + V I I D N+ AP F
Sbjct: 1717 NPYSGVI-TTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQ 1773
Query: 2099 YNLSLSEDALVGSTLVTFSN-------IDHDWTRENTYVEYSIISGNSQNNFHVETKFFH 2151
Y+ SLSE A + S + + N D D R N + Y I+ ++ F V++
Sbjct: 1774 YSGSLSEAAPINSIVRSLDNSPLVIRATDADSNR-NALLVYQIVESTAKKFFTVDS---- 1828
Query: 2152 SEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS--STAVISIQVLDVNDNPPN 2209
G + + +LD E A + DSG P L+ S ++I+V DVNDNPP
Sbjct: 1829 ------STGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPV 1882
Query: 2210 FSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYL 2269
F+ + T + T +G + VSA D D+ E+ Y+++ G+ HF ++ N+GVL
Sbjct: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVL-T 1940
Query: 2270 IKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPI 2329
IK + K + L V+ SD K +S ++V + V + D F S +S + EN
Sbjct: 1941 IKNNNLSK-DHYMLIVKVSDG--KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTN 1997
Query: 2330 SSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI-LDYE 2388
+ + +NA+ L YSI++P + F I +G I + D E
Sbjct: 1998 ITKVAIVNAVGNRLNE--PLKYSILNP----------GNKFKIKSTSGVIQTTGVPFDRE 2045
Query: 2389 NGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGR 2446
Y L V+A + D A +VV V+IE I++ P+F Y+ + + LI +
Sbjct: 2046 EQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQ 2105
Query: 2447 VEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRA 2485
V A D D G +G + Y L F +N +GN+ L A
Sbjct: 2106 VTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEA 2144
Score = 516 bits (1329), Expect = e-145
Identities = 534/2001 (26%), Positives = 864/2001 (43%), Gaps = 167/2001 (8%)
Query: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
F I+P+ G I + +D ER ++Y L+++A T++A G+++ A V + +
Sbjct: 1714 FTINPYSGVITTQKALDYERT-SSYQLIIQA--------TNMA----GMASNATVNIQIV 1760
Query: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVL--------ATDQDSGIYGTVAYELIPGN 220
D NDN PVF S Y S+S E P I+ L ATD DS + Y+++
Sbjct: 1761 DENDNAPVFLFSQYSGSLS-EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVEST 1819
Query: 221 VSSLFTIDSTTG----LYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAA 276
FT+DS+TG + + + E ++ +F S P L VE + E
Sbjct: 1820 AKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS-----PQLTAESPVEVNIEVT 1874
Query: 277 EKK------FEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAK------IL 324
+ +A + + LKV A D E +L + ++
Sbjct: 1875 DVNDNPPVFTQAVFETILLLPTYVGVEVLKVS--ATDPDSEVPPELTYSLMEGSLDHFLI 1932
Query: 325 GEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 384
LT+ ++L L+V DG + + VTI + + + F + Y+
Sbjct: 1933 DSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSM---VTIMVKEAMDSGLHFTQSFYST 1989
Query: 385 LVYEDVPEDSPIGTVKA-REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK-PLDHE 442
+ E+ + + V A LN EP+ Y I + G KF I G I+T P D E
Sbjct: 1990 SISENNTNITKVAIVNAVGNRLN--EPLKYSILNP--GNKFKIKSTSGVIQTTGVPFDRE 2045
Query: 443 TQPVVVLTVQAQLG-SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 501
Q + L V+A + V + + D+NDN P F+ + PGT +Y
Sbjct: 2046 EQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQ 2105
Query: 502 ARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQR-ELTLTLRAEDQG 560
A D+D G NG + Y + G F I+ G + L + + E +T+ A+D G
Sbjct: 2106 VTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGG 2164
Query: 561 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 620
+ + L + I + F+ Y V+E + T +L A P+
Sbjct: 2165 KPSLSTSVELPITIVNKAMP---VFDKPFYTASVNEDIRMNTPILSINA--TSPE--GQG 2217
Query: 621 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 680
+ Y + F I TG + + DYE T Y + A G V+ ++V
Sbjct: 2218 IIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLV 2277
Query: 681 RVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKM 740
D NDN P F + E+ + + ++ +ID DS N + Y ++ D
Sbjct: 2278 N--DVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD------ 2329
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
++ TD+ F D +L + LD E
Sbjct: 2330 --------------------TYNSTDY-FHIDSSSGLILTARM-------------LDHE 2355
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 860
H + V D G P ++ + V++ ++D+NDN P F Q + V E P
Sbjct: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLI----YESYVSELAPRGH 2411
Query: 861 LVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
VT V A D D + + YS+ S + F +D+ +G I + P Y ++V
Sbjct: 2412 FVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV 2471
Query: 921 TDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHY 980
+D G+ A V+I+V+ + SQ+ + EN+ + ++++D Y
Sbjct: 2472 SD-GL--FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTY 2528
Query: 981 NGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVF 1040
G++ ++I+ D F IDS+ G + ++ LD E + T F
Sbjct: 2529 -GQISYAIINDFAKDRFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGG---GRTTF 2583
Query: 1041 LSIDV--EDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQY--YI 1095
++ V D+ND++P F SV +V G LV A D DDG+ NSRI Y Y
Sbjct: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGA--NSRITYSLYS 2641
Query: 1096 ESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVI 1155
E+ + I P G +VT ++ + V A D + V + + I +
Sbjct: 2642 EASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV---KHSLIPVYIHV 2698
Query: 1156 LDVNDHNPTFISFPNAH-VKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFML 1214
L P+F + + ED +GS V + V N+ F++
Sbjct: 2699 LPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVI 2758
Query: 1215 DESSGLLTTTCPLDYEMKTQ-HILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL 1273
++ +G + LD E H + + + + + VLD+ND PVF+
Sbjct: 2759 EQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSS 2818
Query: 1274 YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI----MPGASFELFEINSDTGEVVTT 1329
Y+ + E G +T+V A+D D G N ++ + + P E F I+S+TG + T
Sbjct: 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTL 2878
Query: 1330 TILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE 1388
LD E FT V+ D G SLSST + V D ND+AP F Y V E+
Sbjct: 2879 KDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 1389 PEVVYTVLAS-DMDAGN-NRAVEYHIIDGNTDECFTINEMSGE--LSTTRALDREQISNF 1444
P V VL++ D D + NR V YHI GN F + + E + R LDRE+ +
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
Query: 1445 TLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVD 1504
L I +D ++ V +V V D ND+SP + Y + + ED ++L +SA D
Sbjct: 2999 FLNITATDGLFVTQAMV---EVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
Query: 1505 KDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
D G NG Y L + F +DP SG LKT LDRE ++ A A D G R
Sbjct: 3056 ADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATD---GGGRF 3112
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE 1624
I + + DVNDN PV + ++ + + T V+A D D+G N VV+S A+
Sbjct: 3113 CQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
Query: 1625 TQS-MFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKI 1682
+ +FSID +G I +Q E + + ++ TDQ P ++ + L + + D+
Sbjct: 3173 SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQS-PGQSLSSLTTVTITVLDIND 3231
Query: 1683 S---FSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSG 1738
+ F Y V E+ GT ++ V A + D + Y I SGNE G + K+G
Sbjct: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG 3291
Query: 1739 QLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQAS 1795
++V E LD+E+ L+V A+ G A VA + + D NDN P F Q +Y A
Sbjct: 3292 GISVSE--VLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV 3349
Query: 1796 VSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELT 1855
+SE L VI + A D+DS NG I +SI++G+++ F +D + G++ K LD E
Sbjct: 3350 ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERV 3409
Query: 1856 SSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVS 1914
S YSL+VQA D G+P +S+T + + ++D+NDN+P F P+ + +++ P G + +
Sbjct: 3410 SGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLV 3469
Query: 1915 VHDVD-LNSAFIFSFA-KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-- 1970
V D D ++ FSF+ N +F +D + G++ E EY L +Q DS
Sbjct: 3470 VTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGK 3528
Query: 1971 -VHYTEGALVVRVLDVNDN-PPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR 2028
+ + VRV++ + + P + + VT+ + P G + + ATD + + +++
Sbjct: 3529 PQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGV-IGKIHATDQDMYDVLTFA 3587
Query: 2029 ILSSSKE-FSIDPKNGTIFTI 2048
+ S K F ++ +G I +
Sbjct: 3588 LKSEQKSLFKVNSHDGKIIAL 3608
Score = 499 bits (1284), Expect = e-140
Identities = 491/1794 (27%), Positives = 813/1794 (45%), Gaps = 167/1794 (9%)
Query: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKV 852
N L+RE + ++ + V + RG A V + V D+ND RP F V +
Sbjct: 113 NSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTT----YSVTI 167
Query: 853 LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRP 912
E P+ V V A D D G+N E Y ++ D F + +G I + L+YD +
Sbjct: 168 AESTPLRTSVAQVTATDADIGSNGEFYYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKN 225
Query: 913 SYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI--IPENLKPTKIMSLI 970
Y + ++A D+G+ V + + + R H++ +P +L+ +++
Sbjct: 226 RYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVV 285
Query: 971 KSSDHLQQHYNGKLH-FSIVADDKDGHFEIDS-----STGDLFLSKELDYETTSH-YLFR 1023
+ D L NG++ SIVA D F + + + K++D+E+ + Y
Sbjct: 286 -TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLT 344
Query: 1024 VITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDD 1083
+ D S+ + I ++ F+ E+ +S+ E P G +V + +
Sbjct: 345 LQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP 404
Query: 1084 GSFLNSRIQYYIESHNPGTNP--FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNV 1141
++Y + +PG + F I+P G +VT L+ TV + V
Sbjct: 405 -----IDVEYKL---SPGEDAVYFKINPRSGLIVTARPLN---------TVKKEVYKLEV 447
Query: 1142 TDRRLRSLTAQIVIL--DVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGK 1198
T++ L AQ+ I D NDH P F +A+V E V VG+ V ++A D D+G NG
Sbjct: 448 TNKE-GDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 1199 VTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQ-HILTVLALDDGTPALSSSQ-TLT 1256
+TYSI S N + F++++ +G+++TT LD+E + + V A D G+P S+ +T
Sbjct: 507 ITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL 1316
+ + +VND +P+F++ + + + G +T V A+D D ++++I+ G
Sbjct: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGF 623
Query: 1317 FEINSDTGEV-VTTTILDREIQE-VFTLRVLVRDG------------------GFPSLSS 1356
F +N D+G + + ++ + I+ F LR+ DG S S
Sbjct: 624 FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
Query: 1357 TTTILC-----------------TVEDE-------NDHAPEFIVSSYDIEVLENQEPEV- 1391
T + +ED N P F S+ +V ++ V
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYF-DKSFPSDVAVKEDLPVG 742
Query: 1392 --VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVIL 1449
+ + A D D+G N V + I DGNTD CF I+ +G+L +DRE + L I
Sbjct: 743 ANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNIT 802
Query: 1450 CSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGL 1509
DLG+P +SS L + V DAND+SP F Y ++ E + +GT ++ + A DKD G
Sbjct: 803 IYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862
Query: 1510 NGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI 1568
NG+ Y LTD + F I+ +G + ++ LDRE+++ ++ ARD + G + +V+
Sbjct: 863 NGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVV 920
Query: 1569 -IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFA-ETQ 1626
+KV++ DVND P + + V + + P + D DLG G V +S +
Sbjct: 921 TLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN 980
Query: 1627 SMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKIS-- 1683
F IDK +G I+ + E + L ++ D+G P + + + + +E DV +
Sbjct: 981 GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV-SLSSVSFVEVEVVDVNENLH 1039
Query: 1684 ---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQD-SMKYSIFSGNEDGVLSLCSKSGQ 1739
F G V EN GTS++ V A DS +D ++YSI G+ G S+ +SG
Sbjct: 1040 TPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGV 1099
Query: 1740 LTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASV 1796
+T + LD E L V A G + +V + ++D NDN+P + IY V
Sbjct: 1100 ITAAD--ILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157
Query: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKA-ILDYELT 1855
E+ + VIQ+ A D DS N + Y I SGN + F I+ +G+ITT + LD E
Sbjct: 1158 MENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQ 1217
Query: 1856 SSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEI----TEDSLPGVIVT 1911
+ + L V TD G +T + VQV D NDN P F P + +I + G +
Sbjct: 1218 AEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKRGEPIY 1276
Query: 1912 HVSVHDVDLNSAFIFSFA-KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS 1970
D D S++ + N KF ID TG+V K F + L I+ D+
Sbjct: 1277 RAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDN 1334
Query: 1971 VHYTEGALVVRVLDVNDNPP------VFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN 2024
+ + ++ PP F + FY TV ES V V +S +N
Sbjct: 1335 GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQ--PANTP 1392
Query: 2025 ISYRILSSSKEFSIDPKNGT-IFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIG 2083
+ + I+ + + + D + G I+ L + S VE +DG N A+T V I
Sbjct: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV---AVTQVFIK 1449
Query: 2084 IEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNF 2143
+ D N+ PEF+ +Y++++SED L + ++ D D + +Y +S I S F
Sbjct: 1450 VLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKF 1509
Query: 2144 HVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDV 2203
++ G L LD EA H L I+ D P + A + + V D
Sbjct: 1510 RID----------PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDA 1559
Query: 2204 NDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
ND+ P F++ Y V ES LGS + V+A D+D G +AE+IY I +GN F +E
Sbjct: 1560 NDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPV 1619
Query: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSV-LDDNDHAPQFMFSSFSC 2321
G++ + K D M +F L+++ +D S A+V +SV + DN H P+F+ +
Sbjct: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH-PKFIHKDYQA 1678
Query: 2322 IVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHA 2381
V EN+ I +++ I+A+ L Y + + +F I+P +G I
Sbjct: 1679 EVNENVDIGTSVILISAIS-----QSTLIYEVKDGDI--------NGIFTINPYSGVITT 1725
Query: 2382 KQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441
++ LDYE + Y L +QA + ++ V + I ++ P+F QY +L E
Sbjct: 1726 QKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
Query: 2442 QLIGR-------VEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL 2486
++ + A+DAD+ + +++Y + T+ FF+V+ + G I I L
Sbjct: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
Score = 486 bits (1252), Expect = e-136
Identities = 447/1665 (26%), Positives = 755/1665 (45%), Gaps = 96/1665 (5%)
Query: 873 GNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTI-LSYDYRPSYRMSVIATDQGVPPLQGQ 931
GN S + + FKI + +G I+TT + + + Y + V A+ + +
Sbjct: 2008 GNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVAR 2067
Query: 932 AVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVAD 991
VV + + ++ + + + + +P ++ + + D + NG++ + V
Sbjct: 2068 VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDK-DKGPNGEVTY--VLQ 2124
Query: 992 DKDGHFEIDSSTGDLFLSKELDYETTS-HYLFRVITTDHSKNLSLSSTVFLSIDVEDQND 1050
D GHFEI+ ++G++ L + + + ++ Y ++ D K SLS++V L I + N
Sbjct: 2125 DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP-SLSTSVELPITIV--NK 2181
Query: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
P F SV E++ + T + NA +G I Y I +P F I
Sbjct: 2182 AMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQ----GIIYIIIDGDP-FKQFNIDFD 2236
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP- 1169
G L VS LD E LT+ ASD +T +++ DVND+ P F
Sbjct: 2237 TGVLKVVSPLDYEVTSAYKLTIRASDALTGAR----AEVTVDLLVNDVNDNPPIFDQPTY 2292
Query: 1170 NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT--FMLDESSGLLTTTCPL 1227
N + E +G+ V + + D D N V Y I+ N T F +D SSGL+ T L
Sbjct: 2293 NTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARML 2352
Query: 1228 DYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEF 1287
D+E+ L V ++D G P+LSS + + + DVND PVF Q +YE+ V E G F
Sbjct: 2353 DHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHF 2412
Query: 1288 VTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVR 1347
VT V+A D DS +L++ I+ G F ++S +G + + + ++ +++L V V
Sbjct: 2413 VTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVS 2472
Query: 1348 DGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNR 1406
DG F +ST + V N ++P F S+Y EV EN V V A+D D G
Sbjct: 2473 DGLF---TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYG 2529
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQV 1466
+ Y II+ + F I + +G++ TT LDRE + I L R++ ++V
Sbjct: 2530 QISYAIINDFAKDRFLI-DSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRV 2588
Query: 1467 RVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS---- 1522
V+D ND++P F T+ Y++SVR D G +V + A+D D+G N + Y L EAS
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVA 2648
Query: 1523 GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPV 1582
IDP +G + T ++ + +F A D I S + + ++V P
Sbjct: 2649 DLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHS-LIPVYIHVLPPETFLPS 2707
Query: 1583 LEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ-------SMFSIDKYT 1635
Q+ + ++ ++ T D L + P+ V FS + +F I++ T
Sbjct: 2708 FTQSQYSFTIAEDTAIGST-----VDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQET 2762
Query: 1636 GEIQFQQNPSSEYFPIW---LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL 1692
G I+ + E P + + + + T + + ++ D K F Y +
Sbjct: 2763 GTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI 2822
Query: 1693 VTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNED----GVLSLCSKSGQLTVKEPKF 1747
+ E GT + V+A D + YS+ S ++ ++ S +G ++ K
Sbjct: 2823 IMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTL--KD 2880
Query: 1748 LDFEVRNEVQLIVLAESSGH----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYN 1803
LD E V+A G + V+V + D NDN+P F Q +Y+ +V ES
Sbjct: 2881 LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG 2940
Query: 1804 AHVIQVFATDLD-SGLNGLIEYSILSGNQEEAFQIDALSG--VITTKAILDYELTSSYSL 1860
V + D D S +N + Y I GN F + + + K LD E Y L
Sbjct: 2941 EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFL 3000
Query: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVD 1919
+ ATD G+ +++V V+D+NDN+P + + +P I+ VS D D
Sbjct: 3001 NITATD-GL--FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDAD 3057
Query: 1920 LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGAL 1978
+ S ++ + ++F +D +G + + LD E + Y L+ + +D + + +
Sbjct: 3058 IGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNI 3117
Query: 1979 VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT--DLESNENISYRIL-SSSKE 2035
+ + DVNDNPPVFS D Y V E+ + + A D+ N + Y + S+
Sbjct: 3118 HLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV 3177
Query: 2036 FSIDPKNGTIFTISPVLLLDTISTTQFLVEASD-GGNPDLRALTLVEIGIEDMNNYAPEF 2094
FSID +G I P L + S+ V A+D L +LT V I + D+N+ P F
Sbjct: 3178 FSIDSSSGIIILEQP-LDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVF 3236
Query: 2095 TVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEY 2154
+ Y +++ ED G+ ++ D N + Y I SGN Q F + K
Sbjct: 3237 ERRDYLVTVPEDTSPGTQVLAVFATSKD-IGTNAEITYLIRSGNEQGKFKINPK------ 3289
Query: 2155 PYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS 2214
G + + LD E LV+ A D G P LS+ A ++I + DVNDNPP FS
Sbjct: 3290 ----TGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDV 3345
Query: 2215 YHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLD 2274
Y + E +G + ++ A D D+ + +I ++I++G+ F ++ G++ + K LD
Sbjct: 3346 YSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLD 3405
Query: 2275 YEKMTKFTLTVQASDAE-KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTI 2333
E+++ ++L VQA D+ S A V + + D ND++P F ++++ ++ EN P+ ++I
Sbjct: 3406 RERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSI 3465
Query: 2334 CSINALDFDAGPYG-ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNK 2392
+ D D+ G ++SI+S + + F++DP G + + + + +
Sbjct: 3466 LQLVVTDRDSFHNGPPFSFSILS--------GNEEEEFVLDP-HGILRSAVVFQHTESLE 3516
Query: 2393 YCLTVQAKDKGDATASLVVWVDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLIGRVEAS 2450
Y L VQAKD G ++ + I+E +P + F E + +IG++ A+
Sbjct: 3517 YVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHAT 3576
Query: 2451 DADAGIDGVILYSL-GTSSPFFSVNKTNGNIYLIRALPLIKSQLN 2494
D D + V+ ++L F VN +G I + L K LN
Sbjct: 3577 DQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLN 3619
Score = 424 bits (1091), Expect = e-118
Identities = 474/1843 (25%), Positives = 774/1843 (41%), Gaps = 168/1843 (9%)
Query: 74 VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATY 133
V+ +V+A+D DS + + YSL +G L + F ID + G + + + + +D Y
Sbjct: 1900 VEVLKVSATDPDSEVPPELTYSLMEGSLDH-----FLIDSNSGVLTIKNN-NLSKD--HY 1951
Query: 134 DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193
L+V+ DG + + V + +++ D+ F S Y TSIS+
Sbjct: 1952 MLIVKVSDGK-------------FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
Query: 194 TEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEV 252
T++ V A + + + Y ++ PGN F I ST+G ++ D+E
Sbjct: 1999 TKVAIVNAV--GNRLNEPLKYSILNPGN---KFKIKSTSG-------VIQTTGVPFDREE 2046
Query: 253 MNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDE-------- 304
E+ + R + E F G + ++V E
Sbjct: 2047 QELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQV 2106
Query: 305 -AASADGEAAARYVANLAKILGE--------GIIYLTLPLSHLESTTLSLMVSAQDGGGL 355
A D L G +I S L + + + A+DGG
Sbjct: 2107 TAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGG-- 2164
Query: 356 TAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRI 415
++ V + I A F++P YT V ED+ ++PI ++ A P + I Y I
Sbjct: 2165 KPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP--EGQGIIYII 2222
Query: 416 SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVND 475
GD +F+I G ++ PLD+E LT++A A + V++ V DVND
Sbjct: 2223 IDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVND 2282
Query: 476 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP---QPGVFAIDRA 532
N P F + + +S+ + GT + + D DS N ++ Y I F ID +
Sbjct: 2283 NPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSS 2342
Query: 533 LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQV 592
G++ L + TL +R+ D G ++ +++ + I +P F L+Y+
Sbjct: 2343 SGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPP-VFNQLIYES 2401
Query: 593 EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE 652
VSE L+P + L YS+ D F + +G I L
Sbjct: 2402 YVSE-LAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR 2460
Query: 653 STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 712
Y+ V DG + + V +RV N SP F +V E+ +
Sbjct: 2461 MEPLYSLNVSV---SDGLFTS-TAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI 2516
Query: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
+ A D D G GQ+ Y +++D F+ D
Sbjct: 2517 HVRATDGDPGTYGQISYAIIND----------------------------------FAKD 2542
Query: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 832
F++ S G++I LDRE+ ++++ V R V V V D
Sbjct: 2543 R---FLIDS------NGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDE 2593
Query: 833 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDS---SD 889
NDN P F + V G LVT V A DPD+G N+ +TYS+ SE S +D
Sbjct: 2594 NDNAPQFMTVEYRASVRADVGRGH----LVTQVQAIDPDDGANSRITYSLYSEASVSVAD 2649
Query: 890 HFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS 949
+ID +NG + T + V A D G+P V I V+P +
Sbjct: 2650 LLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFT 2709
Query: 950 QNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIV-----ADDKDGHFEIDSSTG 1004
Q+ I E+ T I S + D L+ + + FS V ++K G F I+ TG
Sbjct: 2710 QSQYSFTIAED---TAIGSTV---DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETG 2763
Query: 1005 DLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
+ L K LD ET+ + F+V T + + TV + I V D ND+ P F+ +
Sbjct: 2764 TIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTII 2823
Query: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPG---TNPFLIHPSFGTLVTVSRLD 1121
E +P+GT + A D D N ++ Y + S + F I + G + T+ LD
Sbjct: 2824 MEGMPVGTKLTQVRAIDMDWG-ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLD 2882
Query: 1122 RESIPTVILTVTASD--QAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVT 1178
E+ PT +V ASD +A +++ L S + + D+ND+ P F +VKE
Sbjct: 2883 HETDPTFTFSVVASDLGEAFSLSSTALVS----VRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 1179 VGSLVHHITAHDPDEGR-NGKVTYSILSGNENMTFMLD--ESSGLLTTTCPLDYEMKTQH 1235
G +V ++ D D N +V+Y I GN F L +S + PLD E + +
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
Query: 1236 ILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALD 1295
L + A D + + V+V DVND +PV Q Y A + E+ + + +V A D
Sbjct: 2999 FLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
Query: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
D G N +++ + + E F ++ ++GE+ T +LDRE V++L DGG
Sbjct: 3056 ADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQ 3114
Query: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYT-VLASDMDAGNNRAVEYHIID 1414
S ++ +ED ND+ P F Y+ V EN + + T V A D D G NR V Y + D
Sbjct: 3115 SNIHLI--LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
Query: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG-DPPRSSVIHLQVRVLDAND 1473
+ F+I+ SG + + LDREQ S++ + + +D SS+ + + VLD ND
Sbjct: 3173 -SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIND 3231
Query: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-TDEASGAFTIDPMSG 1532
+ P F Y +V ED GT VL + A KD G N + Y + + G F I+P +G
Sbjct: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG 3291
Query: 1533 TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFL 1592
+ S LD E + A+D + S + + +TDVNDN P Q+ + +
Sbjct: 3292 GISVSEVLDYELCKRFYLVVEAKDGGTP-ALSAVATVNINLTDVNDNPPKFSQDVYSAVI 3350
Query: 1593 SPESPTNQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFP 1650
S ++ + +++ A+D+D PNG + FS + + F++D G ++ ++ E
Sbjct: 3351 SEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVS 3410
Query: 1651 IW-LQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
+ L ++ D GIPA ++T + I + + D F+ Y ++ EN GTSI+ +
Sbjct: 3411 GYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVV 3470
Query: 1709 FAPDSIQDS--MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG 1766
DS + +SI SGNE+ L ++ E L V A+ SG
Sbjct: 3471 TDRDSFHNGPPFSFSILSGNEEEEFVLDPHG---ILRSAVVFQHTESLEYVLCVQAKDSG 3527
Query: 1767 ---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
++ + V + +E+ + P E + ++ ATD D + ++
Sbjct: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD--MYDVLT 3585
Query: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD 1866
++ L Q+ F++++ G I LD + Y L V +D
Sbjct: 3586 FA-LKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSD 3624
Score = 410 bits (1053), Expect = e-113
Identities = 474/1796 (26%), Positives = 768/1796 (42%), Gaps = 224/1796 (12%)
Query: 877 EVTYSVSSEDSSDHFKI------DANNGEIRT----TTILSYDYRPSYRMSVIATDQGVP 926
++ Y + S D FK D IRT + IL+ + + +Y + V + +G
Sbjct: 78 DIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRG-E 136
Query: 927 PLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHF 986
L+ VNIQV+ ++ R + S + I E+ ++ + ++D NG+ ++
Sbjct: 137 DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATD-ADIGSNGEFYY 195
Query: 987 SIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL----SLSSTVFLS 1042
+K F + ++G + LS L+Y+ + Y ++ D L +SST L
Sbjct: 196 YF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLY 253
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRI--------QYY 1094
+ +E N+H+P+ V E P +V V + D + S Q++
Sbjct: 254 VHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFF 313
Query: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI-LTVTASDQAVNVTDRRLRSLTAQI 1153
+ N + I ++D ES P LT+ A D+ + ++ +L A
Sbjct: 314 LAKEGKWLNEYKIKER-------KQIDWESFPYGYNLTLQAKDKG---SPQKCSALKAVY 363
Query: 1154 VILDVNDHNPTFISFPNAHVKE--DVTVGS-----LVHHITAHDPDEGRNGKVTYSILSG 1206
+ NPT + P KE DV++ +V I P+ V Y + G
Sbjct: 364 I------GNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPI---DVEYKLSPG 414
Query: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1266
+ + F ++ SGL+ T PL+ K + L V + A +T+++ D ND
Sbjct: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA-----QVTISIEDANDHT 469
Query: 1267 PVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL--FEINSDTG 1324
P F+Q LY+A V E+ G V V A D+D G N + + I AS L F IN TG
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI---ASLNLLPFVINQFTG 526
Query: 1325 EVVTTTILDREIQ-EVFTLRVLVRDGGFPSL-SSTTTILCTVEDENDHAPEFI------V 1376
+ TT LD E E++ V D G P S + + + ND++P F V
Sbjct: 527 VISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGV 586
Query: 1377 SSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRAL 1436
SYD P + S +D V+Y II GN F +N SG L ++L
Sbjct: 587 ISYDF-------PVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSL 639
Query: 1437 DREQI--SNFTLVILCSD---LGDPP--RSSVIHLQV----------RV----------- 1468
I NF L I +D L DP SV+H +V RV
Sbjct: 640 TNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
Query: 1469 ------LDANDHSPSFPTL-----YYQSS------VREDAEVGTVVLVLSAVDKDEGLNG 1511
L+ D F ++ Y+ S V+ED VG +L + A D D G NG
Sbjct: 700 AKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
Query: 1512 QTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK 1570
+ + ++D F ID +G LK +DRE + + D +S+ ++
Sbjct: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLG-NPQKSSWRLLT 818
Query: 1571 VYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFS 1630
+ V D NDN PV Q+ + V + S + V A D DLG NG V +S F+
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFA 878
Query: 1631 IDKYTGEI----QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV---KIS 1683
I+ TG + Q + + Y L+++ D+ + ++ + + +DV +
Sbjct: 879 INSSTGIVYVADQLDRESKANYS---LKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA 935
Query: 1684 FSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
F Y V E+ GT I ++ PD + ++YS+ + + +G + SG +
Sbjct: 936 FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASG--AI 992
Query: 1743 KEPKFLDFEVRNEVQLIVLAESSGHR------AYCKVAVLIQDENDNSPCFEQSIYQASV 1796
+ K LD+E + L V A+ G ++ +V V+ +EN ++P F SV
Sbjct: 993 RLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
E+ V+QV A D DSG +G I+YSI G+ F ID SGVIT ILD E
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMG 1112
Query: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV---EITEDSLPGVIVTHV 1913
SY L V ATD+G+ L +T + ++V D+NDNAP L SE + + E+S V V +
Sbjct: 1113 SYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAP--LTSEPIYYPVVMENSPKDVSVIQI 1170
Query: 1914 SVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLV-KTLDFEEMTEYELLIQISD-- 1969
D D +S ++ S NP FAI+ TG++ + LD E+ E+ L + ++D
Sbjct: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
Query: 1970 -SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE--SIPVGYSVLTLSATDLES--NEN 2024
S + +VV+VLD NDN P F + YQ+ +PE G + A D + N
Sbjct: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
Query: 2025 ISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEI 2082
ISY I+ + + F IDPK G +S S ++A D G P + + +
Sbjct: 1291 ISYSIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSYDILTIKAVDNGRP--QKSSTARL 1345
Query: 2083 GIEDMNNYAPE-----FTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG 2137
IE + P F YN ++ E V + S NT + + I+ G
Sbjct: 1346 HIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVS-----VQPANTPLWFDIVGG 1400
Query: 2138 NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV-- 2195
N + F E K VG +V+ LD E + + + + +D ++ AV
Sbjct: 1401 NFDSAFDAE----------KGVGTIVIAKPLDAEQRSIYNMSVEVTDG-----TNVAVTQ 1445
Query: 2196 ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSH-AEIIYNIISGNE 2254
+ I+VLD NDN P FS +Y + E + I + A DRD + +++ I
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSIS 1505
Query: 2255 KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKH-FSFAVVFVSVLDDNDHAPQ 2313
F ++ +TGVLY + LD+E K L + D E + + A V V+V D NDH+P
Sbjct: 1506 MRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPY 1565
Query: 2314 FMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLID 2373
F + V E+ + S + + ALD D G EL Y+I + ++F I+
Sbjct: 1566 FTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA--------GNTGNMFKIE 1617
Query: 2374 PLTGDIHAKQILDYENGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYF 2431
P+ G I + D ++ L+++ D+G +A+ +V + + D P F Y
Sbjct: 1618 PVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQ 1677
Query: 2432 FTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN-IYLIR---ALP 2487
+ E + D G +++ ++ S+ + V + N I+ I +
Sbjct: 1678 AEVNE--------------NVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVI 1723
Query: 2488 LIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISL 2543
+ L+ E T ++I + ++ TV + + ++ P+ +F S +S SL
Sbjct: 1724 TTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLF-SQYSGSL 1778
Score = 140 bits (353), Expect = 2e-32
Identities = 195/847 (23%), Positives = 360/847 (42%), Gaps = 133/847 (15%)
Query: 1787 FEQSIYQASVSESQLYNAHV---IQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGV 1843
F SIY A+V E+ +V ++ T +D L+ I+Y I+SG++E F+ + +
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLID--LSWDIKYRIVSGDEEGFFKAEEVIIA 100
Query: 1844 ------ITTK----AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL 1893
I TK AIL+ E+ +Y LIV+ + +G L T + +QV D+ND P F
Sbjct: 101 DFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFS 159
Query: 1894 PSE-AVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLV 1950
P+ +V I E + V V+ D D+ N F + F N F++ +GV+ L
Sbjct: 160 PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF---KNKVDLFSVHPTSGVISLS 216
Query: 1951 KTLDFEEMTEYELLIQISD---SVHYTEGA-----LVVRVLDVNDNPPVFSQDFYQVTVP 2002
L+++E Y+L I D ++ G L V + +N++ P +
Sbjct: 217 GRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL 276
Query: 2003 ESIPVGYSVLTLSATDLESN---ENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTIST 2059
E P Y+V+T+ D +N E++S +F + K G + I
Sbjct: 277 EKEPT-YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEGKWLNEYKIKERKQIDW 334
Query: 2060 TQF------LVEASDGGNPD-LRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
F ++A D G+P AL V IG + F + Y++S+SE + G
Sbjct: 335 ESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVV 394
Query: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
+ + E VEY + G F + + G +V L+
Sbjct: 395 VAIVK-----LSPEPIDVEYKLSPGEDAVYFKINPRS----------GLIVTARPLNTVK 439
Query: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
++L + + A ++I + D ND+ P F Y +V ES P+G+ + V
Sbjct: 440 KEVYKLEVTNKEGDLK-----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTV 494
Query: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK-FTLTVQASD-- 2289
SA+D+D G + I Y+I S N F + + TGV+ + LD+E + + V+ASD
Sbjct: 495 SASDKDKGENGYITYSIASLNLL-PFVINQFTGVISTTEELDFESSPEIYRFIVRASDWG 553
Query: 2290 AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
+ +H S V + + + ND++P F + ++ + P+ I +++A+D D +
Sbjct: 554 SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--ELELV 611
Query: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQIL---DYENGNKYCLTVQAKDKGDAT 2406
Y I+S + F ++P +G + K+ L +NGN + L + A D +
Sbjct: 612 KYKIIS--------GNELGFFYLNPDSGVLQLKKSLTNSGIKNGN-FALRITATDGENLA 662
Query: 2407 ASLVVWVDI--------------------------------------EGIDEFEPIFTQD 2428
+ + + + +G +F I Q
Sbjct: 663 DPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQG 722
Query: 2429 QYF---FTLPEKNKDRQLIG----RVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGN 2479
YF F K+ +G +++A DAD+G +G +L+++ G + F+++ G
Sbjct: 723 PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQ 782
Query: 2480 IYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSF 2539
+ ++ +P+ + D + I + + K + + +NV +++ +P+ + S+
Sbjct: 783 LKVL--MPMDREH---TDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI-QDSY 836
Query: 2540 SISLVVS 2546
S++++ S
Sbjct: 837 SVNILES 843
Score = 101 bits (252), Expect = 9e-21
Identities = 117/455 (25%), Positives = 203/455 (44%), Gaps = 46/455 (10%)
Query: 2075 RALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSN-----IDHDWTRENTY 2129
+ L V G+ FT YN ++ E++ + + + S ID W
Sbjct: 24 KLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD----- 78
Query: 2130 VEYSIISGNSQNNFHVETKFFHSEYPYKQV----GYLVLLHSLDREASASHELVILASDS 2185
++Y I+SG+ + F E +++ + ++ G +L+ RE ++ L++ S
Sbjct: 79 IKYRIVSGDEEGFFKAEEVII-ADFCFLRIRTKGGNSAILN---REIQDNYLLIVKGSVR 134
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
G L + ++IQVLD+ND P FS +Y + ESTPL + + V+A D D GS+ E
Sbjct: 135 G-EDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
Query: 2246 IYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF------SFAV 2299
Y N+ F + +GV+ L L+Y++ ++ L + A D K + S A
Sbjct: 194 YYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251
Query: 2300 VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL-TYSIVSPCF 2358
++V + N+HAP + VP +L T + D D G GE+ + SIV+
Sbjct: 252 LYVHIERINEHAPTIHVVTH---VPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308
Query: 2359 LTHGMSYDHDLFLIDPLTGDIHAKQILDYEN-GNKYCLTVQAKDKGD---ATASLVVWVD 2414
L +L + I ++ +D+E+ Y LT+QAKDKG +A V++
Sbjct: 309 LDQFFLAKEGKWLNEY---KIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIG 365
Query: 2415 IEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVN 2474
D F ++ Y ++ E + ++ V+ S ID S G + +F +N
Sbjct: 366 NPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP--IDVEYKLSPGEDAVYFKIN 423
Query: 2475 KTNGNIYLIRALPLIKSQL------NKEDTLEMKI 2503
+G I R L +K ++ NKE L+ ++
Sbjct: 424 PRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQV 458
Score = 80.5 bits (197), Expect = 2e-14
Identities = 53/165 (32%), Positives = 79/165 (47%), Gaps = 15/165 (9%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
E A T V A D D G+ + YSL D A F ID G I + Q +DRE
Sbjct: 3142 ENTATKALLTRVQAVDPDIGINRKVVYSLADS-----AGGVFSIDSSSGIIILEQPLDRE 3196
Query: 128 RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 187
+ ++Y++ V A D + LS+ V + + D+NDN PVF Y+ ++
Sbjct: 3197 QQ-SSYNISVRATDQSPGQ---------SLSSLTTVTITVLDINDNPPVFERRDYLVTVP 3246
Query: 188 DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232
++T PGT+++ V AT +D G + Y + GN F I+ TG
Sbjct: 3247 EDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG 3291
Score = 74.3 bits (181), Expect = 2e-12
Identities = 54/166 (32%), Positives = 79/166 (47%), Gaps = 15/166 (9%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE 127
E+ + + V A+ D G I Y + G F+I+P G I VS+ +D E
Sbjct: 3247 EDTSPGTQVLAVFATSKDIGTNAEITYLIRSG----NEQGKFKINPKTGGISVSEVLDYE 3302
Query: 128 RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 187
Y L+VEAKDG LSA A V ++L DVNDN P F+ Y IS
Sbjct: 3303 LCKRFY-LVVEAKDGGTP----------ALSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351
Query: 188 DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
++ G +I ++A D DS G + + ++ G+ + FT+D GL
Sbjct: 3352 EDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGL 3397
Score = 66.6 bits (161), Expect = 3e-10
Identities = 52/173 (30%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 61 AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 120
A+V +E + +VTA D DSG G I+YS+ DG F ID G I
Sbjct: 1047 AVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDG----SGLGRFSIDDESGVITA 1102
Query: 121 SQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPS 180
+ +DRE +Y L V A D L + V +++EDVNDN P+ +
Sbjct: 1103 ADILDRET-MGSYWLTVYATDRGVVP----------LYSTIEVYIEVEDVNDNAPLTSEP 1151
Query: 181 TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Y + + + +I + A D DS + Y + GN + F I+ TGL
Sbjct: 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL 1204
Score = 50.8 bits (120), Expect = 2e-05
Identities = 47/171 (27%), Positives = 68/171 (39%), Gaps = 18/171 (10%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV-SQDIDR 126
E + K V ++ A D DS + Y + G F I+ G I S+ +DR
Sbjct: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSG----NPQNFFAINIKTGLITTTSRKLDR 1214
Query: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 186
E+ A + L V DG + +V V + D NDN P F Y +
Sbjct: 1215 EQQ-AEHFLEVTVTDGGPSPK----------QSTIWVVVQVLDENDNKPQFPEKVYQIKL 1263
Query: 187 S--DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
D + G I A D+D G ++Y ++ GN F ID TG+ S
Sbjct: 1264 PERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVS 1314
Score = 35.0 bits (79), Expect = 1.1
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 15/135 (11%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+VTA+DAD G G Y + F + P G I +S ++ + + YDL +
Sbjct: 179 QVTATDADIGSNGEFYYYFKNKV------DLFSVHPTSGVISLSGRLNYD-EKNRYDLEI 231
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
A D + + G+S+ A + V +E +N++ P + T+V S E +P ++
Sbjct: 232 LAVDRGMKLYGN-----NGVSSTAKLYVHIERINEHAPTIHVVTHV-PFSLEKEPTYAVV 285
Query: 198 NVLATDQDSGIYGTV 212
V D D G G +
Sbjct: 286 TV--DDLDDGANGEI 298
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 660 bits (1703), Expect = 0.0
Identities = 672/2508 (26%), Positives = 1104/2508 (44%), Gaps = 266/2508 (10%)
Query: 61 AIVFRSQEENAKPVKET--EVTASDADSGLYGFIEYSLYDG-FLSYEAPQAFRIDPHDGQ 117
A+ + S +E+A PV + ++ A D DS G + +++ G ++ + F I P G
Sbjct: 1140 AVFYPSIQEDA-PVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGF-----FMIHPVTGL 1193
Query: 118 ICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVF 177
+ +Q +DRE KD +T L + L + + V V + DVNDN P+F
Sbjct: 1194 LSTAQQLDREN-----------KDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIF 1242
Query: 178 NPSTYVTSISDETQPGT--EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
+ + + + P + + ++A+D D G+ G V Y I + F+ID TG+ S
Sbjct: 1243 SHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYS-IEDSDEEAFSIDLVTGVVS 1301
Query: 236 P-------EVEILS-AVNFSADKEVMNSLEM---FLPLLR------HFKKVERDEEAAEK 278
E IL+ S + S+ + ++P R F + E
Sbjct: 1302 SSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
Query: 279 KFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHL 338
+ +GR L + + D ++ K G I + PL
Sbjct: 1362 DPVNHMVGVISVEGRPGLFWFNISGGDKDMD--------FDIEKTTGS--IVIARPLDTR 1411
Query: 339 ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIG 397
+ +L V DG A +HIF +A RP++ YE VP+D+ G
Sbjct: 1412 RRSNYNLTVEVTDGSRTIA-----TQVHIFM--IANINHHRPQFLETRYEVRVPQDTVPG 1464
Query: 398 T----VKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRKPLDHETQPVV-VLT 450
V+A + I+ S D G F + P G + T LD + P LT
Sbjct: 1465 VELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLT 1524
Query: 451 VQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 509
V + P + V I V D N + P F + E + T PGT L RA D D
Sbjct: 1525 VMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADR 1584
Query: 510 GRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 568
G N + YS + G F I+ LG++ L L TLT++AEDQG PQ L
Sbjct: 1585 GVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQG-SPQWHDL 1643
Query: 569 VLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
++ + F Y VE+ ES+ + +L A + S + Y L
Sbjct: 1644 ATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA------MSPSEVTYELREG 1697
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDN 688
+F + Y+G I +++ D+E +Y ++ F V+V + DENDN
Sbjct: 1698 NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAF---TDVMVVVDIIDENDN 1754
Query: 689 SPTFLHDVLFLKVEE-SPVPQGVIGK------ITAIDMDSGKNGQLLYFLLSDG--KFFK 739
+P FL ++ E +P+ ++ K I A D D N L+Y +L KFFK
Sbjct: 1755 APMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFK 1814
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++P+ GT+ +++ +D
Sbjct: 1815 IDPS---MGTLTIVS-----------------------------------------EMDY 1830
Query: 800 EHRGHHEMTVLVTDRGSP----PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 855
E + V V D+GSP PR A V + V D+ND+ P F ++++ + G
Sbjct: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPA--QVIIHVRDVNDSPPRF-----SEQIYEVAIVG 1883
Query: 856 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYR 915
P++ + + + DE ++EV YS+ + ++ + I G I ++L+ + R
Sbjct: 1884 -PIHPGMELLMVRASDE--DSEVNYSIKTGNADEAVTIHPVTGSI---SVLNPAFLGLSR 1937
Query: 916 MSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDH 975
I G+ Q A+V I + + Q++ + ENL+ K + ++ + +
Sbjct: 1938 KLTIRASDGL--YQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGN 1995
Query: 976 LQQHYNGKLHFSIVADDKDGHFEIDSSTGDL-FLSKELDYETTSHYLFRVITTDHSKNLS 1034
H N L + ++ + F + S G L D E + V D+
Sbjct: 1996 ---HLNDTLSYFLL--NGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQR 2050
Query: 1035 LSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYY 1094
++ + + + +ED ND+ P F+ +++ G +++ +A D+D + +
Sbjct: 2051 VAQGL-VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109
Query: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
E + F I P G + D +++ L V A D L+S +++
Sbjct: 2110 AEDY----TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGT----PSLQS-EEEVL 2160
Query: 1155 ILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFM 1213
+ N NP F S + V E++T+ + + H A P+ R + Y+I+ M F
Sbjct: 2161 VTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLR---LIYNIVEEEPLMLFT 2217
Query: 1214 LDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL 1273
D +G+LT T PLDYE KT+H+ TV A D + S + T+ V V DVND P F Q +
Sbjct: 2218 TDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA-TVEVLVEDVNDNPPTFSQLV 2276
Query: 1274 YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS--FELFEINSDTGEVVTTTI 1331
Y S+ E V ++ A D+DSG N + ++I+ S + F+IN TGE+ T
Sbjct: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
Query: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PE 1390
LD E Q+ F ++V D G P L+ T ++ V D ND+ PEF Y+ V E
Sbjct: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
Query: 1391 VVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
+V V A D D+ + +EY I+ GN D F IN SG +S + S++ L +
Sbjct: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGA 2456
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN 1510
S D + + + + +AN +SP F Y++ + E+A VGT V+ L A+DKD G
Sbjct: 2457 S---DGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPY 2513
Query: 1511 GQTEYFLTDE-ASGAFTIDPMSGTLKTSNTLDREARSQHTFS--AVARDCSIQGSRSTTV 1567
G +Y + ++ AS F+I+P +G + T LDRE ++ + +ARD G R
Sbjct: 2514 GTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD---GGGRVAFC 2569
Query: 1568 IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--- 1624
+K+ +TD NDN P + + + V + + + V A D D G N V +S
Sbjct: 2570 TVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDL 2629
Query: 1625 TQSMFSIDKYTGEIQFQ------QNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE 1678
+ + I+ TG ++ + +N + ++F +K D G P L+ + ++
Sbjct: 2630 VKDVIEINPVTGVVKVKDSLVGLENQTLDFF-----IKAQDGGPP--HWNSLVPVRLQVV 2682
Query: 1679 DVKIS---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSG-----NEDGV 1730
K+S FS LY E+ G+ I VKA A QD + YS+ G N+DGV
Sbjct: 2683 PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVA---AQDPVIYSLVRGTTPESNKDGV 2739
Query: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLA---ESSGHRAYCKVAVLIQDENDNSPCF 1787
SL +G + V++P +D E Q+ V+A +++ + V + + D NDN P F
Sbjct: 2740 FSLDPDTGVIKVRKP--MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVF 2797
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS---GNQEEAFQIDALSGVI 1844
E Y+A ++E+ VIQV A D D+G +G + Y + + N E F ID+ SG I
Sbjct: 2798 EADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWI 2857
Query: 1845 TTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902
TT LD E +Y V A D G +LS+ +++V +TD NDNAP F E + E
Sbjct: 2858 TTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVE 2917
Query: 1903 DSLPGVIVTHVSVHDVDLN--SAFIFSFAKESNPGTKFAIDQ--NTGVVVLVKTLDFEEM 1958
+S PG +V + D D++ + + + E +P +F I Q + + KTLD E
Sbjct: 2918 NSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHT 2977
Query: 1959 TEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATD 2018
+Y L + SD + + VLDVNDN P SQ Y V E + G+ +L +SATD
Sbjct: 2978 AKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATD 3037
Query: 2019 LESNEN--ISYRILS-SSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
L+++ N I+Y + + EF +DP G + T++ L + + +A+DGG +
Sbjct: 3038 LDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLT-ALDRERKDVFNLVAKATDGGGRSCQ 3096
Query: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
A + + +ED+N+ AP F +++ ++ V + + D D N V YS +
Sbjct: 3097 A--DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPD-QGANAQVVYS-L 3152
Query: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP-PLSSTA 2194
+++ +F ++ G + L L A EL + ASD G P PLS+
Sbjct: 3153 PDSAEGHFSIDA----------TTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202
Query: 2195 VISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE 2254
+++ V+ + D P F + + V E P G+ + ++ R Y ++SGNE
Sbjct: 3203 TVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG--YRVVSGNE 3260
Query: 2255 KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSVLDDNDHAPQ 2313
+G F L+ TG+LY+ LD+E K+ L+++ S S V V++ D N+H PQ
Sbjct: 3261 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQ 3320
Query: 2314 FMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLID 2373
F +S V EN + I +++A D D ++TYS++ L H F I
Sbjct: 3321 FPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGH--------FTIH 3372
Query: 2374 PLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT--ASLVVWVDIEGIDEFEPIFTQDQYF 2431
P G++ + LD E + Y L ++A D G + + + +++ P F Q Y
Sbjct: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYS 3432
Query: 2432 FTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN 2479
T+ E + + ++ SD D+ +G P +S T GN
Sbjct: 3433 TTVQENSPIGSKVLQLILSDPDSPENG----------PPYSFRITKGN 3470
Score = 605 bits (1561), Expect = e-172
Identities = 665/2515 (26%), Positives = 1097/2515 (43%), Gaps = 253/2515 (10%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
E+T DADS G + Y+L + F + P G++ V+ +DRE +P Y L V
Sbjct: 841 ELTTKDADSEDNGRVRYTLLS------PTEKFSLHPLTGELVVTGHLDRESEPR-YILKV 893
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
EA+D + ++ + + LEDVNDN P + ++ PGT +
Sbjct: 894 EARDQPSKGHQLFSVTD--------LIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT 945
Query: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLE 257
+ A+D D G G V Y L+ G F +D TG E E+ ++ +L
Sbjct: 946 FLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILEREL------DFERRAGYNLS 998
Query: 258 MFL-----PLLR----HFKKVERD--EEAAEKKFEA--SRGWFMRFK-GRRHLHYLKVQD 303
++ PL R H + + D E F + +G + + QD
Sbjct: 999 LWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD 1058
Query: 304 EAASADGEA-----AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAV 358
+ + DGE A +A + G+I PL ++ L V A D G +
Sbjct: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
Query: 359 INADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAREPLNSSE-PIFY 413
+V I + P + + + Y + ED+P+GT + A +P +SS+ + +
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVF----YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTF 1174
Query: 414 RISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMD 472
I+SG+ G F IHP G + T + LD E + +L V P+ ST V + ++D
Sbjct: 1175 NITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILD 1234
Query: 473 VNDNHPAFLRTSDEIRISQTTPPGTA--LYLARAEDRDSGRNGLIRYSIASPQPGVFAID 530
VNDN P F +R+ + P + +Y A D D G NG + YSI F+ID
Sbjct: 1235 VNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSID 1294
Query: 531 RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV--VIEKREHSPSWTFEHL 588
GV+ + + AGE LT++A D G P +A + L + + R S F+
Sbjct: 1295 LVTGVVSSSSTFTAGEYN--ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
Query: 589 VYQVEVSES--LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 646
Y V E+ ++ M ++ + P +++ F I TG I +
Sbjct: 1353 YYSFTVMETDPVNHMVGVISVEGRP-------GLFWFNISGGDKDMDFDIEKTTGSIVIA 1405
Query: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
R D YN V DG + I + + N + P FL ++V + V
Sbjct: 1406 RPLDTRRRSNYNLTVEV---TDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTV 1462
Query: 707 PQGVIGKITAIDMDSGKNGQLLYFL-----LSDGKFFKMNPNTGPAGTIYVITWADGAAA 761
P + ++ AID D GK+ L+Y + F+++P++G T+ +
Sbjct: 1463 PGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKL-------- 1512
Query: 762 FSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNA 821
+LG G H +TV+V D+ P +
Sbjct: 1513 -----------------------DLGSGP------------SQHTLTVMVRDQEIPIKRN 1537
Query: 822 TMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS 881
+ V + V D N + P F Q + + G + V A D D G NAEV YS
Sbjct: 1538 FVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTE----LLQVRAMDADRGVNAEVHYS 1593
Query: 882 VSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPL 941
+ +S F I+A G I L + ++V A DQG P A V I V P
Sbjct: 1594 LLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPS 1653
Query: 942 SKGRAIMSQNIRHLIIPENL---KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFE 998
+ I S++ + IPE++ P ++S + S+ + + + +KDG F
Sbjct: 1654 DRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE---------VTYELREGNKDGVFS 1704
Query: 999 IDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST-VFLSIDVEDQNDHSPSFQD 1057
++S +G + K+LD+E S Y ++ N++ + T V + +D+ D+ND++P F
Sbjct: 1705 MNSYSGLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMFLK 1760
Query: 1058 ELIVISVEENVPIGTLV-------YVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
V + E P+ +++ +V +A D D NS + Y I F I PS
Sbjct: 1761 STFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKE-ANSLLVYKI-LEPEALKFFKIDPS 1818
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVI--LDVNDHNPTFISF 1168
GTL VS +D ES+P+ V DQ V AQ++I DVND P F
Sbjct: 1819 MGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL---FAPRPAQVIIHVRDVNDSPPRF--- 1872
Query: 1169 PNAHVKEDVTVGSL---VHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTC 1225
+ + E VG + + + DE + +V YSI +GN + + +G ++
Sbjct: 1873 -SEQIYEVAIVGPIHPGMELLMVRASDE--DSEVNYSIKTGNADEAVTIHPVTGSISVLN 1929
Query: 1226 PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPG 1285
P + + LT+ A D + + +++ V D++ F Q +Y A+VKEN
Sbjct: 1930 PAFLGLSRK--LTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDR 1984
Query: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTI-LDREIQEVFTLRV 1344
+ + + A + + +N L + ++ G ++F + G + T + DRE Q+ L V
Sbjct: 1985 KALVILGA--QGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAV 2040
Query: 1345 LVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAG 1403
VRD P + + ++ED ND+ P+F Y + + EP +V++ V A+D D G
Sbjct: 2041 EVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLG 2100
Query: 1404 NNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIH 1463
N AV Y + T F I+ G++S + D + ++ + L ++ D G P S
Sbjct: 2101 TNGAVTYEFAEDYT--YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQS--E 2156
Query: 1464 LQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASG 1523
+V V N +P F + YY+ V E+ + T +L A EGL + +E
Sbjct: 2157 EEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQA-RSPEGLR-LIYNIVEEEPLM 2214
Query: 1524 AFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVL 1583
FT D +G L + LD E++++H F+ A D ++ TV +V V DVNDN P
Sbjct: 2215 LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATV--EVLVEDVNDNPPTF 2272
Query: 1584 EQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS----MFSIDKYTGEIQ 1639
Q + +S P + + A D D G N V + E S F I+ TGE+
Sbjct: 2273 SQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMS 2332
Query: 1640 FQQN---PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHLYKGLVTE 1695
Q + ++F + +++ D+G P T L+V+++ D F Y+ V+E
Sbjct: 2333 TVQELDYEAQQHFHV--KVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSE 2390
Query: 1696 NCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKE--PKFLDFEV 1752
G ++ V+A PDS S ++Y I SGN+D + S SG +++ K LD
Sbjct: 2391 LATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD--- 2447
Query: 1753 RNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFAT 1812
+ L V A RA V + + N SP F+Q +Y+A ++E+ + VI + A
Sbjct: 2448 -SSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAI 2506
Query: 1813 DLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDK-GMPR 1871
D DSG G I+Y+I++ E F I+ +G I T LD E ++ + ++ + G R
Sbjct: 2507 DKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGR 2565
Query: 1872 LSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVD--LNSAFIFSF 1928
++ TV K+ +TD NDN P F SE V I + V V +D D N+ +S
Sbjct: 2566 VAFCTV-KIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV---VRVLDV 1985
E I+ TGVV + +L E + I+ D +LV ++V+
Sbjct: 2625 NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPK 2684
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL-----SSSKE--FSI 2038
+ P FS+ Y + PE +P G + + A + + + + Y ++ S+K+ FS+
Sbjct: 2685 KVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA--VAAQDPVIYSLVRGTTPESNKDGVFSL 2742
Query: 2039 DPKNGTIFTISPVLLLDTISTTQFLVE--ASDGGNPDLRALTLVEIGIEDMNNYAPEFTV 2096
DP G I P +D ST + ++ A N D+ +L V I + D+N+ P F
Sbjct: 2743 DPDTGVIKVRKP---MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEA 2799
Query: 2097 KSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Y L+E+ VG++++ + ID D R+ V Y +S + +N H + F +
Sbjct: 2800 DPYKAVLTENMPVGTSVIQVTAIDKDTGRDG-QVSYR-LSADPGSNVH---ELFAID--- 2851
Query: 2157 KQVGYLVLLHSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNFSSLSY 2215
+ G++ L LD E ++ ++A D G LSS A++ + + D NDN P F+S Y
Sbjct: 2852 SESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEY 2911
Query: 2216 HTHVKESTPLGSHITVVSANDRD-TGSHAEIIYNIISGNEKGHFYLEENTGVLYLI---K 2271
V E++ G + + D D + + ++ I G+ G F + + G + I K
Sbjct: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ-VGDEWRISSRK 2970
Query: 2272 PLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
LD E K+ L V ASD K + V + VLD ND++PQ ++ V E++
Sbjct: 2971 TLDREHTAKYLLRVTASDG--KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
Query: 2332 TICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGN 2391
I ++A D D ++TYS+ HG F +DP TG++ LD E +
Sbjct: 3029 FILKVSATDLDTDTNAQITYSL-------HGPGAHE--FKLDPHTGELTTLTALDRERKD 3079
Query: 2392 KYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASD 2451
+ L +A D G + + + +E +++ P F + + + + V A D
Sbjct: 3080 VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARD 3139
Query: 2452 ADAGIDGVILYSLGTSSP-FFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA 2505
D G + ++YSL S+ FS++ T G I L + L Q+ + LE+ + A
Sbjct: 3140 PDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPL-----QVRPQAPLELTVRA 3189
Score = 601 bits (1550), Expect = e-171
Identities = 617/2291 (26%), Positives = 1004/2291 (43%), Gaps = 228/2291 (9%)
Query: 335 LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 394
+ +L LSL + G + I H+ + L+ +FE+ Y + E P S
Sbjct: 323 MEYLHGFNLSLQARSGSGPYFYSQIRG---FHLPPSKLSSLKFEKAVYRVQLSEFSPPGS 379
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 454
+ V+ + + + + SS ++G F ++ R G I T K +D + Q
Sbjct: 380 RVVMVRVTPAFPNLQYVL-KPSSENVG--FKLNARTGLITTTKLMDFHDRA----HYQLH 432
Query: 455 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 514
+ ++P +ST V I ++D N++ P F R+S + + + PPGT++ A DRD G NG
Sbjct: 433 IRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGY 492
Query: 515 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL-TLTLRAEDQGVHPQAALLVLTVV 573
+ YSIA P+ F+ID LG++ + + + + T +RA D G P +++
Sbjct: 493 VTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWG-SPFRREKEVSIF 551
Query: 574 IEKREHSPSWTFEHLVYQVEVSESLS---PMTQMLQTQAHPLGPQRAASPLRYSLEPSVD 630
++ R + + + + +V + S+ P+ + + T + + L+Y + +
Sbjct: 552 LQLRNLNDN---QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE--LQNLKYEIVSGNE 606
Query: 631 SAMFGIRPYTGWIYLRRQF---------------------DYESTQTYN--------FRV 661
F + ++G I L+R F +Y S T N F V
Sbjct: 607 LEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEV 666
Query: 662 FAWIPEDGFLQNVSTTVIVRVWDENDNS-----------------PTFL-HDVLFLKVEE 703
+ G L + T++ + +N S P F H + V E
Sbjct: 667 PVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLE 726
Query: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
S + ++ A D D+G NG+L+Y + ADG
Sbjct: 727 SVPINTPLARLAATDPDAGFNGKLVYVI------------------------ADG----- 757
Query: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 823
+E F + EL G L LD E + + V V D G+P +++
Sbjct: 758 --------NEEGCFDI-----ELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWK 804
Query: 824 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 883
+ V+V D NDN P FP PG + + E V + + KD D +N V Y++
Sbjct: 805 LLTVNVKDWNDNAPRFP---PG-GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL 860
Query: 884 SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQG-------QAVVNI 936
S ++ F + GE+ T L + P Y + V A DQ P +G ++ +
Sbjct: 861 S--PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQ---PSKGHQLFSVTDLIITL 915
Query: 937 QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996
+ + + + I N L +PE+L P +++ + +SD G++ + ++ D G
Sbjct: 916 EDVNDNSPQCITEHN--RLKVPEDLPPGTVLTFLDASDP-DLGPAGEVRY-VLMDGAHGT 971
Query: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQND--HSPS 1054
F +D TG L L +ELD+E + Y + +D + L+ + + + V D N+ H P
Sbjct: 972 FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPH 1031
Query: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTL 1114
F + V+EN P GT V V A+DDD S L+ +QY++ + G F I+ G +
Sbjct: 1032 FASFVHQGQVQENSPSGTQVIVVAAQDDD-SGLDGELQYFLRA-GTGLAAFSINQDTGMI 1089
Query: 1115 VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLT-AQIVILDVNDHNPTF---ISFPN 1170
T++ LDRE LTV A D+ L S+T I + D ND+ P + +P+
Sbjct: 1090 QTLAPLDREFASYYWLTVLAVDRG----SVPLSSVTEVYIEVTDANDNPPQMSQAVFYPS 1145
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
++ED VG+ V + A DPD GK+T++I SGN FM+ +GLL+T LD E
Sbjct: 1146 --IQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRE 1203
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGE--FV 1288
K +HIL V LD+G P+L S+ + V +LDVND P+F L+ + E +P V
Sbjct: 1204 NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPV 1263
Query: 1289 TRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRD 1348
R+ A D D G+N ++ + I + E F I+ TG V +++ + T++ D
Sbjct: 1264 YRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTFTAGEYNILTIK--ATD 1320
Query: 1349 GGFPSLSSTTTILCTVEDENDHAPEFIVSSYD-----IEVLENQEPEVVYTVLASDMDAG 1403
G P LS++ + +E P I ++D V+E + V++ + G
Sbjct: 1321 SGQPPLSASVRL--HIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---G 1375
Query: 1404 NNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIH 1463
++I G+ D F I + +G + R LD + SN+ L + +D G ++ +H
Sbjct: 1376 RPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVH 1434
Query: 1464 LQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN-GQTEYFLTDEAS 1522
+ + + N H P F Y+ V +D G +L + A+D+D+G + T + D S
Sbjct: 1435 I-FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGS 1493
Query: 1523 GA-FTIDPMSGTLKTSNTLD-REARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDND 1580
+ F +DP SG L T LD SQHT + + RD I R+ V + ++V D N +
Sbjct: 1494 ASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRN-FVWVTIHVEDGNLHP 1552
Query: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEI 1638
P Q ++ + + VRA D D G N V +S ++ F+I+ G I
Sbjct: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII 1612
Query: 1639 QFQQN-PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS-FSHHLYKGLVTEN 1696
Q + + P L +K DQG P ++IH+ D FS Y + E+
Sbjct: 1613 TLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPES 1672
Query: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756
G+ I+ V A +P + Y + GN+DGV S+ S SG ++ + K LD E +
Sbjct: 1673 IPVGSPILLVSAMSPSEV----TYELREGNKDGVFSMNSYSGLISTQ--KKLDHEKISSY 1726
Query: 1757 QLIVLAES-SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSE-SQLY------NAHVIQ 1808
QL + + +G V V I DENDN+P F +S + +SE + LY N +
Sbjct: 1727 QLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFV 1786
Query: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
+ A+D D N L+ Y IL + F+ID G +T + +DYE S+ V D+G
Sbjct: 1787 IHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQG 1846
Query: 1869 MPRL--SNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFI 1925
P L + + V D+ND+ P F V I PG+ + V D D +
Sbjct: 1847 SPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYS 1906
Query: 1926 FSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDV 1985
K N I TG + ++ F ++ +L I+ SD ++ + + + V
Sbjct: 1907 I---KTGNADEAVTIHPVTGSISVLNPA-FLGLSR-KLTIRASDGLYQDTALVKISLTQV 1961
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTI 2045
D F QD Y V E++ +++ L A N+ +SY +L+ + F + G +
Sbjct: 1962 LDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVL 2021
Query: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
T + T + VE D P A LV + IED+N+ P+F Y + +
Sbjct: 2022 QTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQD 2081
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
G L S D D N V Y F + +F + PY +G + L
Sbjct: 2082 GTEPGDVLFQVSATDED-LGTNGAVTY---------EFAEDYTYFRID-PY--LGDISLK 2128
Query: 2166 HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
D +A + L ++A D G P L S + + V N + P F S Y V E+ L
Sbjct: 2129 KPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITL 2186
Query: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
+ I A + +IYNI+ F + TGVL + PLDYE TK TV
Sbjct: 2187 YTPILHTQARSPE---GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTV 2243
Query: 2286 QASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
+A+D FS A V V V D ND+ P F ++ + E LP + + + A D D+G
Sbjct: 2244 RATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD- 2404
+++Y IV S F I+ TG++ Q LDYE + + V+A DKGD
Sbjct: 2304 NRDVSYQIV------EDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDP 2357
Query: 2405 -ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS 2463
T +V V++ I++ P F Q QY + E L+ +V+A D D+ + Y
Sbjct: 2358 PLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYL 2417
Query: 2464 L--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKF-ASCTVF 2520
+ G F +N ++G +I L K L+ L + SD F A+ V+
Sbjct: 2418 ILSGNQDRHFFINSSSG---IISMFNLCKKHLDSSYNLRV------GASDGVFRATVPVY 2468
Query: 2521 VNVSFSSEGTP 2531
+N + +++ +P
Sbjct: 2469 INTTNANKYSP 2479
Score = 596 bits (1537), Expect = e-170
Identities = 648/2599 (24%), Positives = 1066/2599 (41%), Gaps = 287/2599 (11%)
Query: 68 EENAKP-VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQA--FRIDPHDGQICVSQDI 124
+EN P VTA+D D G G++ YS+ P+A F IDP+ G I S+ +
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSI-------AGPKALPFSIDPYLGIISTSKPM 520
Query: 125 DRERDPATYDLLVEAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
D E Y V A D G R + + + L ++NDN P+F
Sbjct: 521 DYELMKRIYTFRVRASDWGSPFRR----------EKEVSIFLQLRNLNDNQPMFEEVNCT 570
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL---------- 233
SI + G I+ + A D D + YE++ GN F ++ +G+
Sbjct: 571 GSIRQDWPVGKSIMTMSAIDVDE--LQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINL 628
Query: 234 -------YSPEVEILSAVNFSADKEV------------------MNSLEMFLPLLRHFKK 268
YS ++ N+++ + L F + HF
Sbjct: 629 TAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIG 688
Query: 269 VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAAS----------ADGEAAARYVA 318
++ E + E+ S + + H+ + D S A + A +
Sbjct: 689 LQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNG 748
Query: 319 NLAKILGEG-------------IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI 365
L ++ +G ++ + PL + + L V+ D G +T+
Sbjct: 749 KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTV 808
Query: 366 HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFS 425
++ F Y + ED + I + ++ +S + R + KFS
Sbjct: 809 NVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDA-DSEDNGRVRYTLLSPTEKFS 867
Query: 426 IHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA---CSSTEVNITVMDVNDNHPAFLR 482
+HP G + LD E++P +L V+A+ + S T++ IT+ DVNDN P +
Sbjct: 868 LHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCIT 927
Query: 483 TSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL 542
+ +++ + PPGT L A D D G G +RY + G F +D G L L L
Sbjct: 928 EHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILEREL 987
Query: 543 GAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 600
+ L+L A D G + + V +V++ E+ F V+Q +V E+
Sbjct: 988 DFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPS 1047
Query: 601 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
TQ++ A L+Y L A F I TG I D E Y
Sbjct: 1048 GTQVIVVAAQD-DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLT 1106
Query: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV-EESPVPQGVIGKITAIDM 719
V A + + T V + V D NDN P V + + E++PV V+ ++ A D
Sbjct: 1107 VLA-VDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-QLDAWDP 1164
Query: 720 DSGKNGQLLYFLLSDG--KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAF 777
DS G+L + + S FF ++P TG T
Sbjct: 1165 DSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQ-------------------------- 1198
Query: 778 VLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 837
LDRE++ H + V V D G P +T V V + D+NDN P
Sbjct: 1199 ------------------QLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPP 1240
Query: 838 FFPQCLPGKEL--HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDA 895
F L L + + PV LV A D DEG N VTYS+ D + F ID
Sbjct: 1241 IFSHKLFNVRLPERLSPVSPGPVYRLV----ASDLDEGLNGRVTYSIEDSD-EEAFSIDL 1295
Query: 896 NNGEI-RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAI---MSQN 951
G + ++T + +Y +++ ATD G PPL ++I+ IP + +I +
Sbjct: 1296 VTGVVSSSSTFTAGEYN---ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
Query: 952 IRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKE 1011
+ E ++ +I G F+I DKD F+I+ +TG + +++
Sbjct: 1353 YYSFTVMETDPVNHMVGVISVEGR-----PGLFWFNISGGDKDMDFDIEKTTGSIVIARP 1407
Query: 1012 LDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
LD S+Y V TD S+ ++ +F+ ++ N H P F + + V ++ G
Sbjct: 1408 LDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANI---NHHRPQFLETRYEVRVPQDTVPG 1464
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGT-NPFLIHPSFGTLVTVSRLDRESIPTV-I 1129
+ A D D S I S +PG+ + F + PS G LVTV +LD S P+
Sbjct: 1465 VELLRVQAIDQDKG--KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHT 1522
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITA 1188
LTV DQ + + + + I + D N H P F A V + + G+ + + A
Sbjct: 1523 LTVMVRDQEIPI---KRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRA 1579
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA 1248
D D G N +V YS+L GN F ++ G++T LD H LTV A D G+P
Sbjct: 1580 MDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQ 1639
Query: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
T+ + V + AP+F + Y + E+ G + V A+ S++ +E+
Sbjct: 1640 WHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMS-----PSEVTYEL 1694
Query: 1309 MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN 1368
G +F +NS +G + T LD E ++ + ++ +R + ++ + DEN
Sbjct: 1695 REGNKDGVFSMNSYSGLISTQKKLDHE--KISSYQLKIRGSNMAGAFTDVMVVVDIIDEN 1752
Query: 1369 DHAPEFIVSSYDIEVLE-----------NQEPEVVYTVLASDMDAGNNRAVEYHIIDGNT 1417
D+AP F+ S++ ++ E N P V++ ASD D N + Y I++
Sbjct: 1753 DNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIH---ASDSDKEANSLLVYKILEPEA 1809
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP----PRSSVIHLQVRVLDAND 1473
+ F I+ G L+ +D E + +F + D G P PR + + + VR D ND
Sbjct: 1810 LKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVR--DVND 1867
Query: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT 1533
P F Y+ ++ G +L++ A D+D +N + T A A TI P++G+
Sbjct: 1868 SPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK---TGNADEAVTIHPVTGS 1924
Query: 1534 LKTSNTLDREARSQHTFSAVARDCSIQ---GSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ N F ++R +I+ G T ++K+ +T V D +Q+ +
Sbjct: 1925 ISVLNP---------AFLGLSRKLTIRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWA 1975
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQF-------QQN 1643
+ + VI+ A L N T+ + MF + + G +Q +Q
Sbjct: 1976 AVKENLQDRKALVILGAQGNHL--NDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQ 2033
Query: 1644 PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSHHLYKGLVTENCEAGTS 1702
+ E L ++V D P R GL+ + +E D F H Y ++ + E G
Sbjct: 2034 DTHE-----LAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088
Query: 1703 IVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVL 1761
+ V A D ++ Y + + G +++K+P D++ N+ L V+
Sbjct: 2089 LFQVSATDEDLGTNGAVTYEF--AEDYTYFRIDPYLGDISLKKP--FDYQALNKYHLKVI 2144
Query: 1762 AESSGHRA-YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNG 1820
A G + + VL+ N ++P F+ Y+ V E+ ++ A GL
Sbjct: 2145 ARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARS-PEGLR- 2202
Query: 1821 LIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKV 1880
+ Y+I+ F D +GV+T LDYE + + V+ATD + S TV +V
Sbjct: 2203 -LIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATV-EV 2260
Query: 1881 QVTDINDNAPAFLPSEAVEITEDSLPG---VIVTHVSVHDVDLNSAFIFSFAKESNPGTK 1937
V D+NDN P F + LP VI S D N + ++ + +K
Sbjct: 2261 LVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK 2320
Query: 1938 -FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFS 1993
F I+ +TG + V+ LD+E + + ++ D E +VV V D+NDNPP F
Sbjct: 2321 FFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFR 2380
Query: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNE--NISYRILSSSKE--FSIDPKNGTIFTIS 2049
Q Y+ V E G+ VL + A D +S + + Y ILS +++ F I+ +G I ++
Sbjct: 2381 QPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG-IISMF 2439
Query: 2050 PVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
+ S+ V ASDG RA V I + N Y+PEF Y L+E+A+V
Sbjct: 2440 NLCKKHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMV 2496
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
G+ ++ ID D T ++Y+II+ + F + G + L LD
Sbjct: 2497 GTKVIDLLAIDKDSGPYGT-IDYTIINKLASEKFSINPN-----------GQIATLQKLD 2544
Query: 2170 REASASHELVI--LASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGS 2227
RE S + I +A D G T + I + D NDNPP F + Y ++ + S
Sbjct: 2545 RENSTERVIAIKVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDS 2602
Query: 2228 HITVVSANDRDTGSHAEIIYNIISGN-EKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
+ V A D D G +A++ Y++ + K + TGV+ + L + ++
Sbjct: 2603 PVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIK 2662
Query: 2287 ASDAEKKHF-SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
A D H+ S V + V+ P+F ++ PE+LP S I + A+
Sbjct: 2663 AQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AA 2718
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK--DKG 2403
+ YS+V T S +F +DP TG I ++ +D+E+ Y + V A
Sbjct: 2719 QDPVIYSLVRG---TTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT 2775
Query: 2404 DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYS 2463
D + + V + + +++ P+F D Y L E + +V A D D G DG + Y
Sbjct: 2776 DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYR 2835
Query: 2464 LGTS-----SPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCT 2518
L F+++ +G I ++ L Q T ++A+ + +S
Sbjct: 2836 LSADPGSNVHELFAIDSESGWITTLQELDCETCQ-----TYHFHVVAYDHGQTIQLSS-Q 2889
Query: 2519 VFVNVSFSSEGTPLAVFAS 2537
V VS + E FAS
Sbjct: 2890 ALVQVSITDENDNAPRFAS 2908
Score = 514 bits (1325), Expect = e-145
Identities = 596/2485 (23%), Positives = 1035/2485 (41%), Gaps = 232/2485 (9%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
+ ASD D GL G + YS+ D +AF ID G + S
Sbjct: 1266 LVASDLDEGLNGRVTYSIEDS-----DEEAFSIDLVTGVVSSSSTFTA------------ 1308
Query: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNP----STYVTSISDETQPGT 194
G+ +T A G A VR+ +E + P P TY + ET P
Sbjct: 1309 ---GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVN 1365
Query: 195 EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG--LYSPEVEILSAVNFSADKEV 252
++ V++ + G++ + + G+ F I+ TTG + + ++ N++ EV
Sbjct: 1366 HMVGVISVEGRPGLFW---FNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEV 1422
Query: 253 MNSLEMFLPLLRHFKKVERDE---EAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD 309
+ + F + + E ++E + + L+VQ A D
Sbjct: 1423 TDGSRTIATQVHIFMIANINHHRPQFLETRYEVR----VPQDTVPGVELLRVQ--AIDQD 1476
Query: 310 GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD------- 362
+ Y + ++ G ++ P S + T L + + V+ D
Sbjct: 1477 KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR 1536
Query: 363 ----VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNS-SEPIFYRISS 417
VTIH+ L P F + Y V + + + + V+A + + + Y +
Sbjct: 1537 NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
Query: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDN 476
G+ G F+I+ LG I + LD LTV+A+ +P V I V + +
Sbjct: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
Query: 477 HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGV 535
P F ++ + I ++ P G+ + L A + Y + + GVF+++ G+
Sbjct: 1657 APIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGL 1711
Query: 536 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVS 595
+ L + L +R + ++V+ +I++ +++P + V Q+ S
Sbjct: 1712 ISTQKKLDHEKISSYQLKIRGSNMA-GAFTDVMVVVDIIDENDNAPMFLKSTFVGQI--S 1768
Query: 596 ESLSPMTQMLQTQAHPL------GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQF 649
E+ + ++ +P + A S L Y + F I P G + + +
Sbjct: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEM 1828
Query: 650 DYESTQTYNFRVFAWIPEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
DYES ++ F V+ + + G VI+ V D ND+ P F + + +
Sbjct: 1829 DYESMPSFQFCVY--VHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIH 1886
Query: 707 PQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTD 766
P + + A D DS N + + G N A TI+ +T +
Sbjct: 1887 PGMELLMVRASDEDSEVN-----YSIKTG-------NADEAVTIHPVTGSIS-------- 1926
Query: 767 FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 826
VL F L I R G ++ T LV
Sbjct: 1927 -----------VLNPAFLGLSRKLTI------RASDGLYQDTALVK-------------- 1955
Query: 827 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSED 886
+S+T + D F Q + + + + + + +L +GN+ T S +
Sbjct: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--------QGNHLNDTLSYFLLN 2007
Query: 887 SSDHFKIDANNGEIRTTTI-LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945
+D F + + G ++T + + + ++ ++V D P Q +V + + ++
Sbjct: 2008 GTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNP 2067
Query: 946 AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005
+ II + +P ++ + ++D NG + + D +F ID GD
Sbjct: 2068 PKFKHLPYYTIIQDGTEPGDVLFQVSATDE-DLGTNGAVTYEFAEDYT--YFRIDPYLGD 2124
Query: 1006 LFLSKELDYETTSHYLFRVITTDH-SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
+ L K DY+ + Y +VI D + +L V +++ +N +P FQ + V
Sbjct: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV----RNKSNPLFQSPYYKVRV 2180
Query: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
EN+ + T + A+ +G R+ Y I P F G L LD ES
Sbjct: 2181 PENITLYTPILHTQARSPEGL----RLIYNIVEEEP-LMLFTTDFKTGVLTVTGPLDYES 2235
Query: 1125 IPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLV 1183
+ TV A+D A+ T ++++ DVND+ PTF + E + + V
Sbjct: 2236 KTKHVFTVRATDTALG----SFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPV 2291
Query: 1184 HHITAHDPDEGRNGKVTYSILSGNENMT--FMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
+ A D D GRN V+Y I+ +++ F ++ S+G ++T LDYE + + V A
Sbjct: 2292 IQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRA 2351
Query: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
+D G P L+ + V V D+ND P F+Q YEA+V E G V +V+A+D DS
Sbjct: 2352 MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDT 2411
Query: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
S+L++ I+ G F INS +G + + + + + LRV DG F +T +
Sbjct: 2412 SRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVF---RATVPVY 2468
Query: 1362 CTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
+ N ++PEF Y+ E+ EN V +LA D D+G ++Y II+ E
Sbjct: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528
Query: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
F+IN +G+++T + LDRE + + I R + +++ + D ND+ P F
Sbjct: 2529 FSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKA 2587
Query: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDE--ASGAFTIDPMSGTLKTSN 1538
Y S++ + + V+ + A D DEG N Y + E I+P++G +K +
Sbjct: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKD 2647
Query: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPES-P 1597
+L F A+D ++ V +++ V + P + P F +PE P
Sbjct: 2648 SLVGLENQTLDFFIKAQDGG-PPHWNSLVPVRLQVVPKKVSLPKFSE-PLYTFSAPEDLP 2705
Query: 1598 TNQTTVIVRADDLDLGPNGTVVFSF-------AETQSMFSIDKYTGEIQFQQNPSSEYFP 1650
IV+A + V++S + +FS+D TG I+ ++ E
Sbjct: 2706 EGSEIGIVKA----VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
Query: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTSIVTVK 1707
++ Q+ V + L+ ++++ DV + F YK ++TEN GTS++ V
Sbjct: 2762 LY-QIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
Query: 1708 AFAPDSIQD---SMKYSIFSG-NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
A D+ +D S + S G N + ++ S+SG +T + LD E V+A
Sbjct: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQE--LDCETCQTYHFHVVAY 2878
Query: 1764 SSGH----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD-SGL 1818
G + V V I DENDN+P F Y+ SV E+ V + D D S
Sbjct: 2879 DHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQ 2938
Query: 1819 NGLIEYSILSGNQEEAFQIDALSGV--ITTKAILDYELTSSYSLIVQATDKGMPRLSNTT 1876
N + I G+ F I + I+++ LD E T+ Y L V A+D + +
Sbjct: 2939 NRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD---GKFQASV 2995
Query: 1877 VIKVQVTDINDNAPAFLPSEAV---EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESN 1933
+++ V D+NDN+P S+ + ++ ED PG + VS D+D ++ +++
Sbjct: 2996 TVEIFVLDVNDNSPQC--SQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGP 3053
Query: 1934 PGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGALVVRVLDVNDNPPVF 1992
+F +D +TG + + LD E + L+ + +D + + + V DVNDN P F
Sbjct: 3054 GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRF 3113
Query: 1993 SQDFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSK-EFSIDPKNGTIFTIS 2049
V V ++ V V + A D + +N + Y + S++ FSID G I
Sbjct: 3114 FPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK 3173
Query: 2050 PVLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
P L + + + V ASD G P L L V + + + +Y P F +++ + EDA
Sbjct: 3174 P-LQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAP 3232
Query: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
G+ ++ + + + Y ++SGN Q F ++ + G L + SL
Sbjct: 3233 PGTEVLQLATLTRPGAEK---TGYRVVSGNEQGRFRLDAR----------TGILYVNASL 3279
Query: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH 2228
D E S + L I S LS + + + DVN++ P F Y T V E+ +G
Sbjct: 3280 DFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDV 3339
Query: 2229 ITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
I VSA D D +++I Y++I GN+ GHF + G L + K LD E+ + ++L ++A+
Sbjct: 3340 ILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRAT 3399
Query: 2289 DA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYG 2347
D+ + + + V D ND+ P+F ++S V EN PI S + + D D+ P
Sbjct: 3400 DSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDS-PEN 3458
Query: 2348 ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATA 2407
YS +T G + F + P G + + L Y L +QA D G
Sbjct: 3459 GPPYSF----RITKG--NNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL 3511
Query: 2408 SLVVWVDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG 2465
S + V + ++ + P + F T+ E ++G++ A+D D + YSL
Sbjct: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLA 3569
Query: 2466 ---TSSPFFSVNKTNGNIYLIRALP 2487
T FSV +G I + LP
Sbjct: 3570 EEETLGRHFSVGAPDGKIIAAQGLP 3594
Score = 512 bits (1319), Expect = e-144
Identities = 591/2319 (25%), Positives = 980/2319 (42%), Gaps = 239/2319 (10%)
Query: 327 GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386
G+I T + + L + G T V+ I I F R Y +
Sbjct: 413 GLITTTKLMDFHDRAHYQLHIRTSPGQASTVVV-----IDIVDCNNHAPLFNRSSYDGTL 467
Query: 387 YEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP- 445
E++P + + V A + + +G FSI P LG I T KP+D+E
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
Query: 446 VVVLTVQAQLGSAPACSSTEVNITVM--DVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 503
+ V+A +P EV+I + ++NDN P F + I Q P G ++
Sbjct: 528 IYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMS 587
Query: 504 AEDRDSGRNGLIRYSIAS-PQPGVFAIDRALGVLFLNG---SLGAGEQRELTLTLRAEDQ 559
A D D +N ++Y I S + F ++ GV+ L +L AG+ +L + A D
Sbjct: 588 AIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
Query: 560 GVHPQAALLVLTVVIEKREHSP------------SWTFEHLVYQVEVSESLSPMTQMLQT 607
+ L +TVV + P + T H + S T +
Sbjct: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
Query: 608 QAH------------------------PLGPQRAASP-------LRYSLEPSVDSAMFGI 636
Q + PL A P L Y + + F I
Sbjct: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
Query: 637 RPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHD 695
TG + + DYE+T Y V + + G Q S ++ V V D NDN+P F
Sbjct: 766 ELETGLLTVAAPLDYEATNFYILNVTVY--DLGTPQKSSWKLLTVNVKDWNDNAPRFPPG 823
Query: 696 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITW 755
L + E I ++T D DS NG++ Y LLS + F ++P T
Sbjct: 824 GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLT----------- 872
Query: 756 ADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRG 815
GEL+ LDRE + + V D+
Sbjct: 873 ---------------------------------GELVVTGHLDRESEPRYILKVEARDQP 899
Query: 816 SPPRN--ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 873
S + + +++ D+NDN PQC+ + +KV E P ++T + A DPD G
Sbjct: 900 SKGHQLFSVTDLIITLEDVNDNS---PQCIT-EHNRLKVPEDLPPGTVLTFLDASDPDLG 955
Query: 874 NNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV 933
EV Y V + + F++D G + L ++ R Y +S+ A+D G PL + +
Sbjct: 956 PAGEVRY-VLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGG-RPLARRTL 1013
Query: 934 VNIQVIPLSKGRAIMSQNIRHLI----IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIV 989
+++VI L + + + + EN P+ ++ ++ +G+L + +
Sbjct: 1014 CHVEVIVLDVNENLHPPHFASFVHQGQVQEN-SPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
Query: 990 ADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQN 1049
A F I+ TG + LD E S+Y V+ D ++ LSS + I+V D N
Sbjct: 1073 AGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG-SVPLSSVTEVYIEVTDAN 1131
Query: 1050 DHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHP 1109
D+ P + S++E+ P+GT V +A D D S ++ + I S N F+IHP
Sbjct: 1132 DNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSS-SKGKLTFNITSGN-YMGFFMIHP 1189
Query: 1110 SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTFI-S 1167
G L T +LDRE+ IL VT D + L+S + +V ILDVND+ P F
Sbjct: 1190 VTGLLSTAQQLDRENKDEHILEVTVLDNG----EPSLKSTSRVVVGILDVNDNPPIFSHK 1245
Query: 1168 FPNAHVKEDVTVGS--LVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTC 1225
N + E ++ S V+ + A D DEG NG+VTYSI +E F +D +G+++++
Sbjct: 1246 LFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEE-AFSIDLVTGVVSSSS 1304
Query: 1226 PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPV---FKQHLYEASVKENQ 1282
+ +ILT+ A D G P LS+S L + + + + F + Y +V E
Sbjct: 1305 --TFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET- 1361
Query: 1283 NPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTL 1342
+P + V +++ G+ F I G F+I TG +V LD + + L
Sbjct: 1362 DPVNHMVGVISVEGRPGL---FWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNL 1418
Query: 1343 RVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMD 1401
V V DG +T + + + N H P+F+ + Y++ V ++ P V + V A D D
Sbjct: 1419 TVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQD 1476
Query: 1402 AGNNRAVEYH-IIDGNTDECFTINEMSGELSTTRALD-REQISNFTLVILCSDLGDPPRS 1459
G + H D + F ++ SG L T LD S TL ++ D P +
Sbjct: 1477 KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKR 1536
Query: 1460 SVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLT 1518
+ + + + V D N H P F L+Y++SV + GT +L + A+D D G+N + Y L
Sbjct: 1537 NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
Query: 1519 DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARD-CSIQGSRSTTVIIKVYVTDVN 1577
+ G F I+ + G + + LD+ + HT + A D S Q TVII VY +D
Sbjct: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSD-- 1654
Query: 1578 DNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYT 1635
+ P+ ++ + V + P ++V A + P+ V + E +FS++ Y+
Sbjct: 1655 RSAPIFSKSEYFVEIPESIPVGSPILLVSA----MSPS-EVTYELREGNKDGVFSMNSYS 1709
Query: 1636 GEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVT 1694
G I Q+ E + QLK+ + T ++V+ + E D F + G ++
Sbjct: 1710 GLISTQKKLDHEKISSY-QLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQIS 1768
Query: 1695 ENCEAGTSIVTVK-----AFAPDSIQDS---MKYSIFSGNEDGVLSLCSKSGQLTVKEPK 1746
E + I+ A DS +++ + Y I + G LT+
Sbjct: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE- 1827
Query: 1747 FLDFEVRNEVQLIVLAESSGHRAY-----CKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801
+D+E Q V G +V + ++D ND+ P F + IY+ ++
Sbjct: 1828 -MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIH 1886
Query: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861
++ V A+D DS +N YSI +GN +EA I ++G I+ + L S L
Sbjct: 1887 PGMELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSIS--VLNPAFLGLSRKLT 1940
Query: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAPAF----LPSEAVEITEDSLPGVIVTHVSVHD 1917
++A+D G+ +T ++K+ +T + D + F + E +D VI+ H
Sbjct: 1941 IRASD-GL--YQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHL 1997
Query: 1918 VDLNSAFIFSFAKESNPGTKFAIDQNTGVV-VLVKTLDFEEMTEYELLIQISDS---VHY 1973
D S F+ N F + Q+ GV+ D E+ +EL +++ D+
Sbjct: 1998 NDTLSYFLL------NGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRV 2051
Query: 1974 TEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT--DLESNENISYRILS 2031
+G + V + DVNDNPP F Y + + G + +SAT DL +N ++Y
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111
Query: 2032 SSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYA 2091
F IDP G I P ++ V A DGG P L++ V + + + +N
Sbjct: 2112 DYTYFRIDPYLGDISLKKP-FDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSN-- 2168
Query: 2092 PEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR--ENTYVEYSIISGNSQNNFHVETKF 2149
P F Y + + E+ + ++ I H R E + Y+I+ F + K
Sbjct: 2169 PLFQSPYYKVRVPEN------ITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFK- 2221
Query: 2150 FHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPN 2209
G L + LD E+ H + A+D+ S A + + V DVNDNPP
Sbjct: 2222 ---------TGVLTVTGPLDYESKTKHVFTVRATDTALGSFSE-ATVEVLVEDVNDNPPT 2271
Query: 2210 FSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNII-SGNEKGHFY-LEENTGVL 2267
FS L Y T + E P + + + A+D+D+G + ++ Y I+ G++ F+ + +TG +
Sbjct: 2272 FSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEM 2331
Query: 2268 YLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPEN 2326
++ LDYE F + V+A D + +V V+V D ND+ P+F + V E
Sbjct: 2332 STVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSEL 2391
Query: 2327 LPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILD 2386
+ + A+D D+ L Y I+S G H F I+ +G I +
Sbjct: 2392 ATCGHLVLKVQAIDPDSRDTSRLEYLILS------GNQDRH--FFINSSSGIISMFNLCK 2443
Query: 2387 YENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGR 2446
+ Y L V A D G A++ V+++ +++ P F Q Y L E +
Sbjct: 2444 KHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID 2502
Query: 2447 VEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKII 2504
+ A D D+G G I Y++ +S FS+N NG I ++ L + + E + +K++
Sbjct: 2503 LLAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKL---DRENSTERVIAIKVM 2558
Query: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISL 2543
A + A CTV + ++ ++ P AS +++S+
Sbjct: 2559 ARD--GGGRVAFCTVKIILTDENDNPP-QFKASEYTVSI 2594
Score = 511 bits (1316), Expect = e-144
Identities = 568/2193 (25%), Positives = 940/2193 (42%), Gaps = 263/2193 (11%)
Query: 363 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG 421
V +HI F P Y + ED+P SPI V A + L + +Y ++
Sbjct: 134 VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNT--RS 191
Query: 422 GKFSIHPRLGTIRTRKPLD------HETQ-------------------PVVVLTVQAQLG 456
F+IHP G + L+ HE Q +V+ V+ L
Sbjct: 192 EMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALR 251
Query: 457 SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRN-GLI 515
PA +S V +T D ND T+ + G + D G++ I
Sbjct: 252 KPPAIAS--VVVTPPDSNDG------TTYATVLVDANSSGAEVESVEVVGGDPGKHFKAI 303
Query: 516 RYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
+ S + + ++ + +L+G L+L+A G P + +
Sbjct: 304 KSYARSNEFSLVSVKDINWMEYLHG---------FNLSLQAR-SGSGPYFYSQIRGFHLP 353
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFG 635
+ S S FE VY+V++SE P ++++ + P P L+Y L+PS ++ F
Sbjct: 354 PSKLS-SLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN-----LQYVLKPSSENVGFK 407
Query: 636 IRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHD 695
+ TG I + D+ Y + G ST V++ + D N+++P F
Sbjct: 408 LNARTGLITTTKLMDFHDRAHYQLHIRT---SPG---QASTVVVIDIVDCNNHAPLFNRS 461
Query: 696 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGPAGTIYVIT 754
++E+ P + +TA D D G+NG + Y + F ++P G T
Sbjct: 462 SYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIIST----- 516
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
S + ++K ++ V +D
Sbjct: 517 ----------------SKPMDYELMKRIY----------------------TFRVRASDW 538
Query: 815 GSP-PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 873
GSP R +++++ + ++NDN+P F + + + PV + T+ A D DE
Sbjct: 539 GSPFRREKEVSIFLQLRNLNDNQPMFEEV----NCTGSIRQDWPVGKSIMTMSAIDVDEL 594
Query: 874 NNAEVTYSVSSEDSSDHFKIDANNGEI---RTTTILSYDYRPSYRMSVIATD---QGVPP 927
N + Y + S + ++F ++ +G I R L+ SY + + A+D P
Sbjct: 595 QN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPT 652
Query: 928 LQGQAVV---NIQVIPLSKGRAIMSQ---NIRHLIIPENLKPT--KIMSLI--------- 970
VV + +V +++Q I H I +N + + + SL
Sbjct: 653 TLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTP 712
Query: 971 KSSDHLQQH------------------------YNGKLHFSIVADDKDGHFEIDSSTGDL 1006
+ DH Q +NGKL + I +++G F+I+ TG L
Sbjct: 713 QFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLL 772
Query: 1007 FLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEE 1066
++ LDYE T+ Y+ V D SS L+++V+D ND++P F +++ E
Sbjct: 773 TVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISE 831
Query: 1067 NVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIP 1126
+ +GT + KD D S N R++Y + S T F +HP G LV LDRES P
Sbjct: 832 DTEVGTTIAELTTKDAD-SEDNGRVRYTLLS---PTEKFSLHPLTGELVVTGHLDRESEP 887
Query: 1127 TVILTVTASDQAVNVTDRRLRSLTAQIVIL-DVNDHNPTFISFPN-AHVKEDVTVGSLVH 1184
IL V A DQ +L S+T I+ L DVND++P I+ N V ED+ G+++
Sbjct: 888 RYILKVEARDQPSK--GHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT 945
Query: 1185 HITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDD 1244
+ A DPD G G+V Y ++ G TF +D +G L LD+E + + L++ A D
Sbjct: 946 FLDASDPDLGPAGEVRYVLMDGAHG-TFRVDLMTGALILERELDFERRAGYNLSLWASDG 1004
Query: 1245 GTP-ALSSSQTLTVTVLDVND--EAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
G P A + + V VLDVN+ P F +++ V+EN G V V A D DSG++
Sbjct: 1005 GRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLD 1064
Query: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
+LQ+ + G F IN DTG + T LDRE + L VL D G LSS T +
Sbjct: 1065 GELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVY 1124
Query: 1362 CTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
V D ND+ P+ + + + E+ V + A D D+ + + ++I GN
Sbjct: 1125 IEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGF 1184
Query: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
F I+ ++G LST + LDRE L + D G+P S + V +LD ND+ P F
Sbjct: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Query: 1481 LYYQSSVREDAEVGTV----VLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKT 1536
+ +VR + V V L A D DEGLNG+ Y + D AF+ID ++G + +
Sbjct: 1245 KLF--NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
Query: 1537 SNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDVF 1591
S+T A + + A D G + +++++ + P ++ +
Sbjct: 1303 SSTF--TAGEYNILTIKATD---SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFT 1357
Query: 1592 LSPESPTNQTTVIVRADDLDLGPNGTVVFSFA--ETQSMFSIDKYTGEIQFQQNPSSEYF 1649
+ P N ++ + G G F+ + + F I+K TG I + +
Sbjct: 1358 VMETDPVNHMVGVISVE----GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRR 1413
Query: 1650 PIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
+ L ++VTD T + +I + F Y+ V ++ G ++ V+A
Sbjct: 1414 SNYNLTVEVTDGSRTIATQVHIFMIANINHH-RPQFLETRYEVRVPQDTVPGVELLRVQA 1472
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCS---KSGQLTVKEPKFLDFEVRNEVQLIVL--AE 1763
D S+ Y+I + G SL SG L L +++ E
Sbjct: 1473 IDQDK-GKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQE 1531
Query: 1764 SSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
R + V + ++D N + P F Q Y+ASV ++ ++QV A D D G+N +
Sbjct: 1532 IPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVH 1591
Query: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVT 1883
YS+L GN E F I+AL G+IT LD + ++L V+A D+G P+ + + + V
Sbjct: 1592 YSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVY 1651
Query: 1884 DINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQ 1942
+ +AP F SE VEI E G + VS ++ + + +E N F+++
Sbjct: 1652 PSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA----MSPSEVTYELREGNKDGVFSMNS 1707
Query: 1943 NTGVVVLVKTLDFEEMTEYELLIQISDSV-HYTEGALVVRVLDVNDNPPVFSQDFYQVTV 2001
+G++ K LD E+++ Y+L I+ S+ +T+ +VV ++D NDN P+F + + +
Sbjct: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQI 1767
Query: 2002 PESIPVGYS----------VLTLSATDLESNENISYRIL--SSSKEFSIDPKNGTIFTIS 2049
E+ P+ YS V+ S +D E+N + Y+IL + K F IDP GT+ TI
Sbjct: 1768 SEAAPL-YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTL-TIV 1825
Query: 2050 PVLLLDTISTTQFLVEASDGGNPDLRA--LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA 2107
+ +++ + QF V D G+P L A V I + D+N+ P F+ + Y +++
Sbjct: 1826 SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPI 1885
Query: 2108 LVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
G L+ D E++ V YSI +GN+ + + G + +L+
Sbjct: 1886 HPGMELLMVRASD-----EDSEVNYSIKTGNADEAVTI----------HPVTGSISVLN- 1929
Query: 2168 LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGS 2227
S +L I ASD TA++ I + V D F Y VKE+
Sbjct: 1930 -PAFLGLSRKLTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRK 1985
Query: 2228 HITVVSANDRDTGSHAE--IIYNIISGNEKGHFYLEENTGVLYLI-KPLDYEKMTKFTLT 2284
+ ++ A G+H + Y +++G + F++ ++ GVL D E+ L
Sbjct: 1986 ALVILGAQ----GNHLNDTLSYFLLNGTDM--FHMVQSAGVLQTRGVAFDREQQDTHELA 2039
Query: 2285 VQASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA 2343
V+ D + + +V VS+ D ND+ P+F + I+ + + ++A D D
Sbjct: 2040 VEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDL 2099
Query: 2344 GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
G G +TY D+ F IDP GDI K+ DY+ NKY L V A+D G
Sbjct: 2100 GTNGAVTYEFAE----------DYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
Query: 2404 DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPE 2436
+ V + ++ P+F Y +PE
Sbjct: 2150 TPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPE 2182
Score = 495 bits (1274), Expect = e-139
Identities = 512/2021 (25%), Positives = 851/2021 (42%), Gaps = 237/2021 (11%)
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
S +W F H Y + E+ SP T + + + +RY + + +F Y
Sbjct: 28 SSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEY 87
Query: 640 T--GWIYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 691
+ +LR + +T N + + E T V+V + D+ND P
Sbjct: 88 VVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL 147
Query: 692 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIY 751
F + + E + I K+TA D D G+N + Y + + F ++P +G
Sbjct: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSG------ 201
Query: 752 VITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL-INWVALDREHRGHHEMTVL 810
V+T A G+L + W RG HE+ VL
Sbjct: 202 VVTVA--------------------------------GKLNVTW-------RGKHELQVL 222
Query: 811 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDP 870
DR + I++ F L +HV+ +P + V D
Sbjct: 223 AVDR--------------MRKISEGNGF--GSLAALVVHVEPALRKPPAIASVVVTPPDS 266
Query: 871 DEG------------NNAEV-TYSVSSEDSSDHFKIDANNGEIRTTTILS------YDYR 911
++G + AEV + V D HFK + +++S +Y
Sbjct: 267 NDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYL 326
Query: 912 PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIK 971
+ +S+ A P Q + + P + + + + E P + +++
Sbjct: 327 HGFNLSLQARSGSGPYFYSQ-IRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR 385
Query: 972 SSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSK 1031
+ L + + ++ F++++ TG + +K +D+ +HY + T+
Sbjct: 386 VTPAFP-----NLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSP--- 437
Query: 1032 NLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRI 1091
+STV + ID+ D N+H+P F +++EN+P GT V A D D N +
Sbjct: 438 --GQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHG-ENGYV 493
Query: 1092 QYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTV-ILTVTASDQAVNVTDRRLRSLT 1150
Y I P PF I P G + T +D E + + V ASD RR + ++
Sbjct: 494 TYSIA--GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF--RREKEVS 549
Query: 1151 AQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNEN 1209
+ + ++ND+ P F +++D VG + ++A D DE +N K Y I+SGNE
Sbjct: 550 IFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLK--YEIVSGNEL 607
Query: 1210 MTFMLDESSGL---------LTTTCPLDYEMK---------------------------- 1232
F L+ SG+ LT P Y +K
Sbjct: 608 EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVP 667
Query: 1233 ---------TQHILTVLALDDGTPALSSSQTLT-VTVLDVNDEAPVFKQHLYEA-SVKEN 1281
TQ T+L SS + T ++ +N P F+ H ++ V E+
Sbjct: 668 VTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLES 727
Query: 1282 QNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFT 1341
+ R+ A D D+G N KL + I G F+I +TG + LD E +
Sbjct: 728 VPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYI 787
Query: 1342 LRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLAS-DM 1400
L V V D G P SS + V+D ND+AP F Y + + E+ E L + D
Sbjct: 788 LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDA 847
Query: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRS- 1459
D+ +N V Y ++ + E F+++ ++GEL T LDRE + L + D P +
Sbjct: 848 DSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARD--QPSKGH 903
Query: 1460 ---SVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516
SV L + + D ND+SP T + + V ED GTV+ L A D D G G+ Y
Sbjct: 904 QLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV 963
Query: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
L D A G F +D M+G L LD E R+ + S A D +R T ++V V DV
Sbjct: 964 LMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDV 1023
Query: 1577 NDN--DPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM--FSID 1632
N+N P + SP+ ++V A D D G +G + + + FSI+
Sbjct: 1024 NENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSIN 1083
Query: 1633 KYTGEIQFQQNPSSEYFP-IWLQLKVTDQG-IPARTTTGLLVIHMEGEDVKISFSHHLYK 1690
+ TG IQ E+ WL + D+G +P + T + + + D S ++
Sbjct: 1084 QDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFY 1143
Query: 1691 GLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLD 1749
+ E+ GTS++ + A+ PD S + + ++I SGN G + +G L+ + LD
Sbjct: 1144 PSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ--LD 1201
Query: 1750 FEVRNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSE--SQLYNA 1804
E ++E L V +G ++ +V V I D NDN P F ++ + E S +
Sbjct: 1202 RENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPG 1261
Query: 1805 HVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI-VQ 1863
V ++ A+DLD GLNG + YSI + EEAF ID ++GV+++ + Y+++ ++
Sbjct: 1262 PVYRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILTIK 1317
Query: 1864 ATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGV---IVTH-VSVHDVD 1919
ATD G P LS + +++ + I P+ +P A + T S + V H V V V+
Sbjct: 1318 ATDSGQPPLSAS--VRLHIEWIPWPRPSSIPL-AFDETYYSFTVMETDPVNHMVGVISVE 1374
Query: 1920 LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGAL 1978
+ + F I++ TG +V+ + LD + Y L ++++D S
Sbjct: 1375 GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVH 1434
Query: 1979 VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI-----LSSS 2033
+ + ++N + P F + Y+V VP+ G +L + A D + +++ Y I S+
Sbjct: 1435 IFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSA 1494
Query: 2034 KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPE 2093
F +DP +G + T+ + L S V D P R V I +ED N + P
Sbjct: 1495 SLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPR 1554
Query: 2094 FTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSE 2153
FT Y S+ + G+ L+ +D D N V YS++ GNS+ F++
Sbjct: 1555 FTQLHYEASVPDTIAPGTELLQVRAMDAD-RGVNAEVHYSLLKGNSEGFFNINA------ 1607
Query: 2154 YPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSL 2213
+G + L LD+ A H L + A D G P A + I V + + P FS
Sbjct: 1608 ----LLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKS 1663
Query: 2214 SYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPL 2273
Y + ES P+GS I +VSA S +E+ Y + GN+ G F + +G++ K L
Sbjct: 1664 EYFVEIPESIPVGSPILLVSAM-----SPSEVTYELREGNKDGVFSMNSYSGLISTQKKL 1718
Query: 2274 DYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTI 2333
D+EK++ + L ++ S+ F+ +V V ++D+ND+AP F+ S+F + E P+ S I
Sbjct: 1719 DHEKISSYQLKIRGSNMAGA-FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMI 1777
Query: 2334 CS-------INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILD 2386
I+A D D L Y I+ P L F IDP G + +D
Sbjct: 1778 MDKNNNPFVIHASDSDKEANSLLVYKILEPEAL--------KFFKIDPSMGTLTIVSEMD 1829
Query: 2387 YENGNKYCLTVQAKDKGD----ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQ 2442
YE+ + V D+G A V + + +++ P F++ Y +
Sbjct: 1830 YESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGM 1889
Query: 2443 LIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLI 2483
+ V ASD D+ ++ I G + +++ G+I ++
Sbjct: 1890 ELLMVRASDEDSEVNYSI--KTGNADEAVTIHPVTGSISVL 1928
Score = 354 bits (908), Expect = 8e-97
Identities = 403/1473 (27%), Positives = 637/1473 (43%), Gaps = 136/1473 (9%)
Query: 146 RMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD 205
R T AL G ++A V V +EDVNDN P F+ Y TSIS+ T +I +LA+DQD
Sbjct: 2244 RATDTAL---GSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
Query: 206 SGIYGTVAYELIP--GNVSSLFTIDSTTGLYSP--EVEILSAVNFSADKEVMNSLEMFLP 261
SG V+Y+++ +VS F I+ +TG S E++ + +F M+ + P
Sbjct: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDP--P 2358
Query: 262 LLRHFKKV-------ERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAA 314
L V + E + ++EA+ HL LKVQ + +
Sbjct: 2359 LTGETLVVVNVSDINDNPPEFRQPQYEAN---VSELATCGHL-VLKVQAIDPDSRDTSRL 2414
Query: 315 RYVA-------NLAKILGEGIIYL-TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 366
Y+ + GII + L HL+S+ +L V A DG V A V ++
Sbjct: 2415 EYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSS-YNLRVGASDG-----VFRATVPVY 2468
Query: 367 IFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGTVKAREPL---NSSEP---IFYRISSGD 419
I T A P++ +YE ++ E++ +GT K + L S P I Y I +
Sbjct: 2469 INTTN---ANKYSPEFQQHLYEAELAENAMVGT-KVIDLLAIDKDSGPYGTIDYTIINKL 2524
Query: 420 LGGKFSIHPRLGTIRTRKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNH 477
KFSI+P G I T + LD E T+ V+ + V A+ G T V I + D NDN
Sbjct: 2525 ASEKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCT-VKIILTDENDNP 2582
Query: 478 PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP---GVFAIDRALG 534
P F + + I + + A D D G+N + YS+ +P+ V I+ G
Sbjct: 2583 PQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV-NPEDLVKDVIEINPVTG 2641
Query: 535 VLFLNGSLGAGEQRELTLTLRAEDQGV-HPQAALLVLTVVIEKREHSPSWTFEHLVYQVE 593
V+ + SL E + L ++A+D G H + + V V+ K+ P F +Y
Sbjct: 2642 VVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPK--FSEPLYTFS 2699
Query: 594 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 653
E L +++ +A S +R + S +F + P TG I +R+ D+ES
Sbjct: 2700 APEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
Query: 654 TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVL-FLKVEESPVPQGVIG 712
T+ Y V A ++ + ++ +V ++V D NDN P F D + E PV VI
Sbjct: 2760 TKLYQIDVMAHCLQNTDVVSL-VSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI- 2817
Query: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
++TAID D+G++GQ+ Y L +D P ++ + FA S+
Sbjct: 2818 QVTAIDKDTGRDGQVSYRLSAD-----------PGSNVHEL-------------FAIDSE 2853
Query: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 832
L+ L CE + + VA D H T+ ++ + V VS+TD
Sbjct: 2854 SGWITTLQELDCETCQTYHFHVVAYD------HGQTIQLSSQA--------LVQVSITDE 2899
Query: 833 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYSVSSEDSSDHF 891
NDN P F +E V+E LV T+ D D N +VT ++ D F
Sbjct: 2900 NDNAPRFAS----EEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQF 2955
Query: 892 KIDANNGEIRTTT--ILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS 949
I E R ++ L ++ Y + V A+D Q V I V+ ++ S
Sbjct: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCS 3012
Query: 950 QNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLS 1009
Q + + E++ P + + ++D L N ++ +S+ F++D TG+L
Sbjct: 3013 QLLYTGKVHEDVFPGHFILKVSATD-LDTDTNAQITYSLHGPGAH-EFKLDPHTGELTTL 3070
Query: 1010 KELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVP 1069
LD E + TD S +++ VED ND++P F ++V +N
Sbjct: 3071 TALDRERKDVFNLVAKATDGGGR---SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTT 3127
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+ T V V A+D D N+++ Y + G F I + G + L +
Sbjct: 3128 VKTPVAVVFARDPDQG-ANAQVVYSLPDSAEGH--FSIDATTGVIRLEKPLQVRPQAPLE 3184
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHI-T 1187
LTV ASD + L ++T +V L+ D+ P F++ ++ V ED G+ V + T
Sbjct: 3185 LTVRASDLGTPIPLSTLGTVTVSVVGLE--DYLPVFLNTEHSVQVPEDAPPGTEVLQLAT 3242
Query: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247
P + G Y ++SGNE F LD +G+L LD+E ++ L++ +
Sbjct: 3243 LTRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS 3299
Query: 1248 ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE 1307
+LS T+ V + DVN+ P F Q Y V EN G+ + V A D D +NS + +
Sbjct: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
Query: 1308 IMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDE 1367
++ G F I+ GE+ LDRE ++L++ D G P L T I V D
Sbjct: 3360 LIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADV 3419
Query: 1368 NDHAPEFIVSSYDIEVLENQE--PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+ P F +Y V EN +V+ +L+ N + I GN F +
Sbjct: 3420 NDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP 3479
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
G L T L R + L I SD G PP SS+ ++V V + + ++PS L
Sbjct: 3480 -DGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFI 3538
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS--GAFTIDPMSGTLKTSNTLDRE 1543
+V ED G +V + A D+D Y L +E + F++ G + + L
Sbjct: 3539 TVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGL--- 3593
Query: 1544 ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
R ++F+ D G+ +TT + VYV V
Sbjct: 3594 PRGHYSFNVTVSD----GTFTTTAGVHVYVWHV 3622
Score = 325 bits (833), Expect = 4e-88
Identities = 374/1471 (25%), Positives = 631/1471 (42%), Gaps = 165/1471 (11%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTFISFPNAHV--KED 1176
L+RE + L + A+++ + L +LT +V ILD ND P F S P+ V ED
Sbjct: 107 LNREVRDSYTLIIQATEKTLE-----LEALTRVVVHILDQNDLKPLF-SPPSYRVTISED 160
Query: 1177 VTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHI 1236
+ + S + +TA D D G+N + Y+ + +E F + +SG++T L+ + +H
Sbjct: 161 MPLKSPICKVTATDADLGQNAEFYYAFNTRSE--MFAIHPTSGVVTVAGKLNVTWRGKHE 218
Query: 1237 LTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEAL-D 1295
L VLA+D + ++ L V+ E + K + V + + T L D
Sbjct: 219 LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278
Query: 1296 RDSGVNSKLQFEIM---PGASFELFEINSDTGEVVTTTILDREIQEV---FTLRVLVRDG 1349
+S E++ PG F+ + + + E ++ D E F L + R G
Sbjct: 279 ANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSG 338
Query: 1350 GFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAV- 1408
P S + H P +SS E + VY V S+ +R V
Sbjct: 339 SGPYFYS--------QIRGFHLPPSKLSSLKFE-------KAVYRVQLSEFSPPGSRVVM 383
Query: 1409 ----------EYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPR 1458
+Y + + + F +N +G ++TT+ +D +++ L I S P +
Sbjct: 384 VRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS----PGQ 439
Query: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518
+S + + + ++D N+H+P F Y ++ E+ GT VL ++A D+D G NG Y +
Sbjct: 440 ASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA 498
Query: 1519 DEASGAFTIDPMSGTLKTSNTLDREARSQ-HTFSAVARDCSIQGSRSTTVIIKVYVTDVN 1577
+ F+IDP G + TS +D E + +TF A D R V I + + ++N
Sbjct: 499 GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
Query: 1578 DNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE 1637
DN P+ E+ + + P ++ + + A D+D N F ++ ++G
Sbjct: 559 DNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGV 618
Query: 1638 IQFQQ---NPSSEYFPIWLQLKVT---DQGIPARTTTGLLVI------------------ 1673
I ++ N ++ P LK+T + + TT + V+
Sbjct: 619 ISLKRPFINLTAGQ-PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLT 677
Query: 1674 -------------HMEGEDVKIS-------------FSHHLYKGL-VTENCEAGTSIVTV 1706
+ E D + + F H + + V E+ T + +
Sbjct: 678 QFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARL 737
Query: 1707 KAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS 1765
A PD+ + Y I GNE+G + ++G LTV P LD+E N L V
Sbjct: 738 AATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAP--LDYEATNFYILNVTVYDL 795
Query: 1766 G---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLI 1822
G ++ + V ++D NDN+P F YQ ++SE + ++ D DS NG +
Sbjct: 796 GTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRV 855
Query: 1823 EYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRLSNTTVIK 1879
Y++LS E F + L+G + LD E Y L V+A D KG S T +I
Sbjct: 856 RYTLLS--PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI- 912
Query: 1880 VQVTDINDNAPAFLPS-EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF 1938
+ + D+NDN+P + +++ ED PG ++T + D DL A + F
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTF 972
Query: 1939 AIDQNTGVVVLVKTLDFEEMTEYELLIQISDS----VHYTEGALVVRVLDVNDN--PPVF 1992
+D TG ++L + LDFE Y L + SD T + V VLDVN+N PP F
Sbjct: 973 RVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHF 1032
Query: 1993 SQDFYQVTVPESIPVGYSVLTLSATD----LESNENISYRILSSSKEFSIDPKNGTIFTI 2048
+ +Q V E+ P G V+ ++A D L+ R + FSI+ G I T+
Sbjct: 1033 ASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTL 1092
Query: 2049 SPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
+P L + S V A D G+ L ++T V I + D N+ P+ + + S+ EDA
Sbjct: 1093 AP-LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAP 1151
Query: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
VG++++ D D + + + ++I SGN F + + G L L
Sbjct: 1152 VGTSVLQLDAWDPDSSSKGK-LTFNITSGNYMGFFMI----------HPVTGLLSTAQQL 1200
Query: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE--STPLG 2226
DRE H L + D+G P L ST+ + + +LDVNDNPP FS ++ + E S
Sbjct: 1201 DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP 1260
Query: 2227 SHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
+ + A+D D G + + Y+I +E+ F ++ TGV+ + LT++
Sbjct: 1261 GPVYRLVASDLDEGLNGRVTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGEYN--ILTIK 1317
Query: 2287 ASDAEKKHFSFAV----VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD 2342
A+D+ + S +V ++ + F + +S V E P++ + I+
Sbjct: 1318 ATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
Query: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDK 2402
G G ++I G D D F I+ TG I + LD + Y LTV+ D
Sbjct: 1374 EGRPGLFWFNI-------SGGDKDMD-FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG 1425
Query: 2403 GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
A+ V I I+ P F + +Y +P+ + RV+A D D G ++Y
Sbjct: 1426 SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIY 1483
Query: 2463 SL-GTSSP----FFSVNKTNGNIYLIRALPL 2488
++ G+ P F ++ ++G + + L L
Sbjct: 1484 TIHGSQDPGSASLFQLDPSSGVLVTVGKLDL 1514
Score = 266 bits (681), Expect = 2e-70
Identities = 311/1237 (25%), Positives = 523/1237 (42%), Gaps = 148/1237 (11%)
Query: 1374 FIVSSYDIEVLENQEPEVVYTVLASDMD---AGNNRAVEYHIIDGNTDECFTINE----- 1425
F S Y+ + EN P+ Y M A AV Y II G+ F E
Sbjct: 33 FTHSHYNATIYENSSPKT-YVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGN 91
Query: 1426 -----MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
+ + S T L+RE ++TL+I ++ ++ + V +LD ND P F
Sbjct: 92 FCFLRIRTKSSNTALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSP 150
Query: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
Y+ ++ ED + + + ++A D D G N + Y+ + S F I P SG + + L
Sbjct: 151 PSYRVTISEDMPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIHPTSGVVTVAGKL 209
Query: 1541 DREARSQHTFSAVA----RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPF--DVFLSP 1594
+ R +H +A R S + + V+V +P L + P V ++P
Sbjct: 210 NVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHV------EPALRKPPAIASVVVTP 263
Query: 1595 ESPTNQTT---VIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPI 1651
+ TT V+V A+ V + +I Y +F +
Sbjct: 264 PDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDIN-- 321
Query: 1652 WLQ-LKVTDQGIPARTTTG------LLVIHMEGEDVK-ISFSHHLYKGLVTENCEAGTSI 1703
W++ L + + AR+ +G + H+ + + F +Y+ ++E G+ +
Sbjct: 322 WMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRV 381
Query: 1704 VTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
V V+ +++Y + +E+ L +++G +T K +DF R QL +
Sbjct: 382 VMVRV---TPAFPNLQYVLKPSSENVGFKLNARTGLITTT--KLMDFHDRAHYQLHI--R 434
Query: 1764 SSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
+S +A V + I D N+++P F +S Y ++ E+ V+ V ATD D G NG +
Sbjct: 435 TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVT 494
Query: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSS-YSLIVQATDKGMP-RLSNTTVIKVQ 1881
YSI +G + F ID G+I+T +DYEL Y+ V+A+D G P R I +Q
Sbjct: 495 YSI-AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQ 553
Query: 1882 VTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
+ ++NDN P F I +D G + +S DVD + N F +
Sbjct: 554 LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIV-SGNELEYFDL 612
Query: 1941 DQNTGVVVLVK---TLDFEEMTEYELLIQISDSVHYTE---------------------- 1975
+ +GV+ L + L + T Y L I SD +Y
Sbjct: 613 NHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDK 672
Query: 1976 -GALV------------------------VRVLDVNDNPPVFSQDFYQ-VTVPESIPVGY 2009
G L + +N P F F Q + V ES+P+
Sbjct: 673 TGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINT 732
Query: 2010 SVLTLSATDLES--NENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065
+ L+ATD ++ N + Y I ++E F I+ + G + +P LD +T +++
Sbjct: 733 PLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAP---LDYEATNFYILN 789
Query: 2066 AS--DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW 2123
+ D G P + L+ + ++D N+ AP F Y L++SED VG+T+ + D D
Sbjct: 790 VTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDAD- 848
Query: 2124 TRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILAS 2183
+ +N V Y+++S + + H T G LV+ LDRE+ + L + A
Sbjct: 849 SEDNGRVRYTLLSPTEKFSLHPLT------------GELVVTGHLDRESEPRYILKVEAR 896
Query: 2184 D--SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGS 2241
D S L S + I + DVNDN P + V E P G+ +T + A+D D G
Sbjct: 897 DQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGP 956
Query: 2242 HAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA----EKKHFSF 2297
E+ Y ++ G G F ++ TG L L + LD+E+ + L++ ASD ++
Sbjct: 957 AGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCH 1015
Query: 2298 AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPC 2357
V V +++N H P F V EN P + + + A D D+G GEL Y
Sbjct: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY------ 1069
Query: 2358 FLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLV--VWVDI 2415
FL G F I+ TG I LD E + Y LTV A D+G S V V++++
Sbjct: 1070 FLRAGTGL--AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
Query: 2416 EGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSV 2473
++ P +Q ++ ++ E + +++A D D+ G + +++ G FF +
Sbjct: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMI 1187
Query: 2474 NKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKS 2510
+ G L+ + + E LE+ ++ + S
Sbjct: 1188 HPVTG---LLSTAQQLDRENKDEHILEVTVLDNGEPS 1221
Score = 67.0 bits (162), Expect = 3e-10
Identities = 61/213 (28%), Positives = 95/213 (44%), Gaps = 15/213 (7%)
Query: 2087 MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146
+++ A FT YN ++ E++ + + +F + V Y IISG+ N F E
Sbjct: 26 LSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTE 85
Query: 2147 TKFFHSEYPYKQVGYLVLLHS------LDREASASHELVILASDSGCPPLSSTAVISIQV 2200
EY +L + L+RE S+ L+I A++ + T V+ + +
Sbjct: 86 ------EYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVV-VHI 138
Query: 2201 LDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYL 2260
LD ND P FS SY + E PL S I V+A D D G +AE Y + +E F +
Sbjct: 139 LDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM--FAI 196
Query: 2261 EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK 2293
+GV+ + L+ K L V A D +K
Sbjct: 197 HPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRK 229
Score = 65.5 bits (158), Expect = 7e-10
Identities = 53/171 (30%), Positives = 77/171 (45%), Gaps = 19/171 (11%)
Query: 67 QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126
QE + + V A D DSGL G ++Y L G AF I+ G I +DR
Sbjct: 1042 QENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG----TGLAAFSINQDTGMIQTLAPLDR 1097
Query: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVT 184
E A+Y L T LA+ +G LS+ V +++ D NDN P + + +
Sbjct: 1098 EF--ASYYWL-----------TVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYP 1144
Query: 185 SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
SI ++ GT ++ + A D DS G + + + GN F I TGL S
Sbjct: 1145 SIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLS 1195
Score = 53.9 bits (128), Expect = 2e-06
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 17/127 (13%)
Query: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
F+++ G I ++ +D D A Y L + G A V +D+
Sbjct: 406 FKLNARTGLITTTKLMDFH-DRAHYQLHIRTSPGQ---------------ASTVVVIDIV 449
Query: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 228
D N++ P+FN S+Y ++ + PGT ++ V ATD+D G G V Y I G + F+ID
Sbjct: 450 DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYS-IAGPKALPFSID 508
Query: 229 STTGLYS 235
G+ S
Sbjct: 509 PYLGIIS 515
Score = 47.4 bits (111), Expect = 2e-04
Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 19/198 (9%)
Query: 377 FERPKYTFLVYEDVPEDSPIGTVKAREPLNS--SEP---IFYRISSGDLGGKFSIHPRLG 431
F Y +YE+ SP V++ E + +EP + YRI SGD+ F +
Sbjct: 33 FTHSHYNATIYEN---SSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVV 89
Query: 432 ------TIRTRKP----LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481
IRT+ L+ E + L +QA + + T V + ++D ND P F
Sbjct: 90 GNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFS 149
Query: 482 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGS 541
S + IS+ P + + A D D G+N Y+ + + +FAI GV+ + G
Sbjct: 150 PPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF-NTRSEMFAIHPTSGVVTVAGK 208
Query: 542 LGAGEQRELTLTLRAEDQ 559
L + + L + A D+
Sbjct: 209 LNVTWRGKHELQVLAVDR 226
Score = 38.5 bits (88), Expect = 0.098
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 157 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 216
L A V V + D ND P+F+P +Y +IS++ + I V ATD D G Y
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 217 IPGNVSSLFTIDSTTGL 233
S +F I T+G+
Sbjct: 188 --NTRSEMFAIHPTSGV 202
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 399 bits (1025), Expect = e-110
Identities = 307/959 (32%), Positives = 455/959 (47%), Gaps = 37/959 (3%)
Query: 1052 SPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES--HNPGTNPFLIHP 1109
+P FQ +V EN P GT V A D D R++Y +++ + F + P
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG-RLEYTMDALFDSRSNQFFSLDP 236
Query: 1110 SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP 1169
G + T LDRE+ T + VTA D + RR T I++ D NDH+P F
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVTDTNDHDPVFEQQE 293
Query: 1170 -NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN---ENMTFMLDESSGLLTTTC 1225
++E++ VG V + A D D N + Y +L G+ + F +D SG++ T
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 1226 PLDYEMKTQHILTVLALDDGTPALSSSQTLTV--TVLDVNDEAPVFKQHLYEASVKENQN 1283
P+D E + LTV A D G S T V +V D ND AP F + Y V+E+
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
Query: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343
PG V RV A DRD G N+ + + IM G + F +++ TG + + LD E + +TLR
Sbjct: 414 PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
Query: 1344 VLVRDGGFPSLSSTTTILCT-VEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMD 1401
V +DGG P LS+ + ++ V D ND+AP F+ + + VLE+ +V V A D D
Sbjct: 474 VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 1402 AGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSV 1461
AG+N +EY + D FTIN +G +S LDRE++ ++ + D G P ++
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
Query: 1462 IHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-E 1520
+ V VLD ND++P+F Y + EDA VGT V+ +SAVD+D + Y +T
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
Query: 1521 ASGAFTIDPMS--GTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578
F+I S G + + LD + Q+ + A D G+R T I V VTD N
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD----GTRQDTAQIVVNVTDANT 707
Query: 1579 NDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEI 1638
+ PV + + + V ++ + P T V++ A D D G N + + ++ F ID TG +
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAV 767
Query: 1639 QFQQNPSSE-YFPIWLQLKVTDQGIPART-TTGLLVIHMEGEDVKISFSHHLYKGLVTEN 1696
Q E L + D GIP ++ TT L ++ + D F Y+G V E+
Sbjct: 768 TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
Query: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756
TS++ + A DS + + F G +DG +S V+ + LD E +
Sbjct: 828 VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQY 887
Query: 1757 QLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATD 1813
L A G R +V V + D NDN P FEQ + V E+ V +V ATD
Sbjct: 888 VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 1814 LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLS 1873
D G N I Y I+ GN E FQ+D SG +T LDYE Y L++QAT P +S
Sbjct: 948 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT--SAPLVS 1005
Query: 1874 NTTVIKVQVTDINDNAPA-----FLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
TV V++ D NDN P L + V S PG + V HD D++ + +SF
Sbjct: 1006 RATV-HVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSF 1064
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVND 1987
+ N + ++ +TG + L + LD E + + +SD VH +RV + D
Sbjct: 1065 -ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
Score = 385 bits (988), Expect = e-106
Identities = 301/956 (31%), Positives = 453/956 (47%), Gaps = 58/956 (6%)
Query: 1475 SPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT----DEASGAFTIDPM 1530
+P F YQ++V E+ GT V L A+D DEG G+ EY + ++ F++DP+
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+G + T+ LDRE +S H F A+D + RS + + VTD ND+DPV EQ +
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE-----TQSMFSIDKYTGEIQFQQNPS 1645
L + VRA D D PN +++ E +F ID +G I+ +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 1646 SEYFPIW-LQLKVTDQGI---PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGT 1701
E + L ++ +DQG P TT + + + D FS Y V E+ G
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
Query: 1702 SIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV 1760
++ V A D +++ YSI SGN G L +++G L V P LD+E E L V
Sbjct: 417 PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYETTKEYTLRV 474
Query: 1761 LAESSGHRAYCKVAVLIQ----DENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS 1816
A+ G V+ L+ D NDN+P F + +QA+V ES V+ V A D D+
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 1817 GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTT 1876
G N +EY + + F I+ +G I+ A LD E YS V+A D G P L+ +
Sbjct: 535 GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 1877 VIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPG 1935
+ V V D+NDN P F P V + ED+ G V VS D D +S + N
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITS-GNTR 653
Query: 1936 TKFAIDQNTG--VVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFS 1993
+F+I +G +V L LD++ +Y L + SD +VV V D N + PVF
Sbjct: 654 NRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQ 713
Query: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNGTIFTISPV 2051
Y V V E P G +V+ +SATD ++ EN I+Y + S +F ID G + T + +
Sbjct: 714 SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAEL 773
Query: 2052 LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGS 2111
D +S T + A D G P T +EI + D+N+ AP+F SY S+ ED +
Sbjct: 774 DYEDQVSYT-LAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
Query: 2112 TLVTFSNIDHDWTRENTYVEYSIISGNS-QNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
+++ S D D + N V Y+ G+ +F VE+ G + L LDR
Sbjct: 833 SVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTS----------GIVRTLRRLDR 881
Query: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230
E A + L A D G PP + +++ VLDVNDNPP F + V+E++P+G +
Sbjct: 882 ENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941
Query: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290
V+A D D G++A+I+Y I+ GN F L+ +G L + LDYE ++ L +QA+ A
Sbjct: 942 RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA 1001
Query: 2291 EKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
S A V V +LD ND+ P + +F+++ + P I + A D D
Sbjct: 1002 PL--VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDIS- 1057
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401
LTYS + L L++ TG++ + LD + ++V D
Sbjct: 1058 -DSLTYSF--------ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 362 bits (930), Expect = 2e-99
Identities = 297/920 (32%), Positives = 442/920 (48%), Gaps = 45/920 (4%)
Query: 957 IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVA--DDKDGHF-EIDSSTGDLFLSKELD 1013
+PEN ++ +++ D + G+L +++ A D + F +D TG + ++ELD
Sbjct: 190 VPENQPAGTPVASLRAIDP-DEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELD 248
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTL 1073
ET S ++FRV DH S+ L+I V D NDH P F+ + S+ EN+ +G
Sbjct: 249 RETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYE 307
Query: 1074 VYVFNAKDDDGSFLNSRIQYYIESHNPG--TNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
V A D D N+ I Y + + G + F I P G + T +DRE + + LT
Sbjct: 308 VLTVRATDGDAP-PNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN----AHVKEDVTVGSLVHHIT 1187
V ASDQ D RS TA V L V D N F V+EDVT G+ V +T
Sbjct: 367 VEASDQG---RDPGPRSTTA-AVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422
Query: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247
A D D+G N V YSI+SGN F LD +G L PLDYE ++ L V A D G P
Sbjct: 423 ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
Query: 1248 ALSS-SQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
LS+ S +TV VLD+ND AP+F ++A+V E+ G V V+A+D D+G N++L++
Sbjct: 483 PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
+ F IN+ TG + LDRE + ++ V RD G P+L+++ ++ TV D
Sbjct: 543 RLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
Query: 1367 ENDHAPEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTI 1423
ND+ P F Y + + N++ V V TV A D DA + + Y I GNT F+I
Sbjct: 603 VNDNNPTFTQPEYTVRL--NEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSI 658
Query: 1424 NEMSGE--LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481
SG +S LD + + L + S D R + V V DAN H P F +
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQYVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVFQSS 715
Query: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLD 1541
+Y +V ED GT V+++SA D+D G N + YF+ D F ID +G + T LD
Sbjct: 716 HYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDADTGAVTTQAELD 774
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQT 1601
E + +T + ARD I +S T +++ V DVNDN P ++ + + + P +
Sbjct: 775 YEDQVSYTLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
Query: 1602 TVIVRADDLDLGPNGTVVFSFA---ETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKV 1657
+ + A D D G NG V ++F + F ++ +G ++ + E + L+
Sbjct: 834 VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
Query: 1658 TDQGI-PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQ 1715
D+G+ PART + V ++ D F + V EN G ++ V A PD
Sbjct: 894 VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
Query: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAV 1775
+ Y I GN V L SG+LT LD+E R E L++ A S+ + V V
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVD--LDYEDRPEYVLVIQATSAPLVSRATVHV 1011
Query: 1776 LIQDENDNSPC---FEQSIYQASVSESQLYNAHVI-QVFATDLDSGLNGLIEYSILSGNQ 1831
+ D NDN P FE + S + I +V A D D ++ + YS GN+
Sbjct: 1012 RLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNE 1069
Query: 1832 EEAFQIDALSGVITTKAILD 1851
++A +G + LD
Sbjct: 1070 LSLVLLNASTGELKLSRALD 1089
Score = 358 bits (918), Expect = 6e-98
Identities = 296/953 (31%), Positives = 446/953 (46%), Gaps = 43/953 (4%)
Query: 852 VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDHFKIDANNGEIRTTTILSY 908
V E QP V ++ A DPDEG + Y++ + S+ F +D G + T L
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
Query: 909 DYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMS 968
+ + ++ V A D G+P A + I V + + Q + ENL+ +
Sbjct: 250 ETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVL 309
Query: 969 LIKSSDHLQQHYNGKLHFSIV---ADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
++++D N + + ++ FEID +G + +D E Y V
Sbjct: 310 TVRATDG-DAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
Query: 1026 TTDHSKN---LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD- 1081
+D ++ S ++ VFLS VED ND++P F ++ V+ V E+V G V A D
Sbjct: 369 ASDQGRDPGPRSTTAAVFLS--VEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDR 426
Query: 1082 DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNV 1141
D GS N+ + Y I S N F + G L VS LD E+ L V A D
Sbjct: 427 DKGS--NAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPP 483
Query: 1142 TDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVT 1200
+T Q +LD+ND+ P F+S P A V E V +G LV H+ A D D G N ++
Sbjct: 484 LSNVSGLVTVQ--VLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLE 541
Query: 1201 YSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260
Y + + F ++ +G ++ LD E + V A D GTPAL++S +++VTVL
Sbjct: 542 YRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVL 601
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
DVND P F Q Y + E+ G V V A+DRD+ +S + ++I G + F I
Sbjct: 602 DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSIT 659
Query: 1321 SDTGE--VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS 1378
S +G V LD +++ + L V DG + T I+ V D N H P F S
Sbjct: 660 SQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSH 716
Query: 1379 YDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALD 1437
Y + V E++ V + A+D D G N + Y + D F I+ +G ++T LD
Sbjct: 717 YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELD 774
Query: 1438 REQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV 1497
E ++TL I D G P +S +L++ V D ND++P F YQ SV ED T V
Sbjct: 775 YEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSV 834
Query: 1498 LVLSAVDKDEGLNGQTEYFLT--DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVAR 1555
L +SA D+D GLNG+ Y D+ G F ++ SG ++T LDRE +Q+ A A
Sbjct: 835 LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAV 894
Query: 1556 DCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPN 1615
D + +R T + + V V DVNDN PV EQ+ FDVF+ SP V A D D G N
Sbjct: 895 DKGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
Query: 1616 GTVVFSFAE--TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLV 1672
+++ E +F +D ++GE+ + E P + L ++ T + +R T + +
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRL 1013
Query: 1673 IHMEGEDVKISFSHHLYKGLVTENCEA--GTSIVTVKAFAPDSIQDSMKYSIFSGNEDGV 1730
+ + L+ VT + G +I V A PD I DS+ YS GNE +
Sbjct: 1014 LDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD-ISDSLTYSFERGNELSL 1072
Query: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH--RAYCKVAV-LIQDE 1780
+ L + +G+L K + LD E + VL H A C + V +I DE
Sbjct: 1073 VLLNASTGEL--KLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDE 1123
Score = 354 bits (908), Expect = 8e-97
Identities = 257/803 (32%), Positives = 402/803 (50%), Gaps = 55/803 (6%)
Query: 1689 YKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYS---IFSGNEDGVLSLCSKSGQLTVKE 1744
Y+ V EN AGT + +++A PD + ++Y+ +F + SL +G +T E
Sbjct: 186 YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAE 245
Query: 1745 PKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801
LD E ++ V A+ G A + +L+ D ND+ P FEQ Y+ S+ E+
Sbjct: 246 E--LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLE 303
Query: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGN---QEEAFQIDALSGVITTKAILDYELTSSY 1858
V+ V ATD D+ N I Y +L G+ E F+ID SGVI T+ +D E SY
Sbjct: 304 VGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESY 363
Query: 1859 SLIVQATDKGM---PRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVS 1914
L V+A+D+G PR S T + + V D NDNAP F V++ ED PG V V+
Sbjct: 364 QLTVEASDQGRDPGPR-STTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422
Query: 1915 VHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS--- 1970
D D S + ++ S N +F +D TG + +V LD+E EY L ++ D
Sbjct: 423 ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482
Query: 1971 -VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISY 2027
+ G + V+VLD+NDN P+F +Q TV ES+P+GY VL + A D ++ +N + Y
Sbjct: 483 PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542
Query: 2028 RILSSSKEFSIDPKNGTIF-TISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIED 2086
R+ +F NGT + +++ L + + F VEA D G P L A V + + D
Sbjct: 543 RLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLD 602
Query: 2087 MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146
+N+ P FT Y + L+EDA VG+++VT S +D D ++ + Y I SGN++N F +
Sbjct: 603 VNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD---AHSVITYQITSGNTRNRFSIT 659
Query: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206
++ G + L LD + + L + ASD TA I + V D N +
Sbjct: 660 SQ--------SGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
Query: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGV 2266
P F S Y +V E P G+ + ++SA D DTG +A I Y + F ++ +TG
Sbjct: 709 RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY--FMEDSIPQFRIDADTGA 766
Query: 2267 LYLIKPLDYEKMTKFTLTVQASD---AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIV 2323
+ LDYE +TL + A D +K ++ + V+ D ND+APQF+ S+ V
Sbjct: 767 VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVN--DVNDNAPQFLRDSYQGSV 824
Query: 2324 PENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQ 2383
E++P +++ I+A D D+G G + Y+ G D D F+++ +G + +
Sbjct: 825 YEDVPPFTSVLQISATDRDSGLNGRVFYTFQG------GDDGDGD-FIVESTSGIVRTLR 877
Query: 2384 ILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441
LD EN +Y L A DKG A + V V + +++ P+F QD++ + E +
Sbjct: 878 RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
Query: 2442 QLIGRVEASDADAGIDGVILYSL 2464
+ RV A+D D G + I+Y +
Sbjct: 938 LAVARVTATDPDEGTNAQIMYQI 960
Score = 348 bits (894), Expect = 3e-95
Identities = 290/955 (30%), Positives = 437/955 (45%), Gaps = 91/955 (9%)
Query: 711 IGKITAIDMDSGKNGQLLY-----FLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGT 765
+ + AID D G+ G+L Y F +FF ++P TG +T A+
Sbjct: 200 VASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG------AVTTAE-------- 245
Query: 766 DFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 825
LDRE + H V D G P R+A +
Sbjct: 246 ------------------------------ELDRETKSTHVFRVTAQDHGMPRRSALATL 275
Query: 826 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV--- 882
+ VTD ND+ P F Q +E + E V V TV A D D NA + Y +
Sbjct: 276 TILVTDTNDHDPVFEQ----QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG 331
Query: 883 SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPP--LQGQAVVNIQVIP 940
S S+ F+ID +G IRT + + SY+++V A+DQG P A V + V
Sbjct: 332 SGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVED 391
Query: 941 LSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEID 1000
+ S+ + + E++ P + + +SD + N +H+SI++ + G F +D
Sbjct: 392 DNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDR-DKGSNAVVHYSIMSGNARGQFYLD 450
Query: 1001 SSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
+ TG L + LDYETT Y RV D + + + +++ V D ND++P F
Sbjct: 451 AQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPF 510
Query: 1061 VISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRL 1120
+V E+VP+G LV A D D N+R++Y + PF I+ G + + L
Sbjct: 511 QATVLESVPLGYLVLHVQAIDADAGD-NARLEYRLAGVGHDF-PFTINNGTGWISVAAEL 568
Query: 1121 DRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTV 1179
DRE + V A D T S + + +LDVND+NPTF + ED V
Sbjct: 569 DREEVDFYSFGVEARDHG---TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAV 625
Query: 1180 GSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESS--GLLTTTCPLDYEMKTQHIL 1237
G+ V ++A D D + +TY I SGN F + S GL++ PLDY+++ Q++L
Sbjct: 626 GTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVL 683
Query: 1238 TVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD 1297
V A DGT + + V V D N PVF+ Y +V E++ G V + A D D
Sbjct: 684 AVTA-SDGT--RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED 740
Query: 1298 SGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357
+G N+++ + + S F I++DTG V T LD E Q +TL + RD G P S T
Sbjct: 741 TGENARITYFMED--SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
Query: 1358 TTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGN 1416
T + V D ND+AP+F+ SY V E+ P V + A+D D+G N V Y G+
Sbjct: 799 TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGD 858
Query: 1417 T-DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHS 1475
D F + SG + T R LDRE ++ + L D G PP + + + V VLD ND+
Sbjct: 859 DGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
Query: 1476 PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTL 1534
P F + V E++ +G V ++A D DEG N Q Y + + F +D SG L
Sbjct: 919 PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978
Query: 1535 KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSP 1594
LD E R ++ A + SR+T + V + D NDN PVL F++ +
Sbjct: 979 TALVDLDYEDRPEYVLVIQATSAPLV-SRAT---VHVRLLDRNDNPPVL--GNFEILFN- 1031
Query: 1595 ESPTNQTTVI-------VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQ 1642
TN+++ V A D D+ + T F S+ ++ TGE++ +
Sbjct: 1032 NYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSR 1086
Score = 340 bits (873), Expect = 9e-93
Identities = 281/945 (29%), Positives = 428/945 (45%), Gaps = 74/945 (7%)
Query: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-----AETQSMFSIDKYT 1635
P + + + P +RA D D G G + ++ + + FS+D T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 1636 GEIQF-----QQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLY 1689
G + ++ S+ F + Q D G+P R+ L I + + D F Y
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQ----DHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 1690 KGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDG---VLSLCSKSGQLTVKEP 1745
K + EN E G ++TV+A D+ ++ + Y + G+ V + +SG + + P
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 1746 KFLDFEVRNEVQLIVLAESSGH-----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800
+D E QL V A G V + ++D+NDN+P F + Y V E
Sbjct: 355 --VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 1801 LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSL 1860
A V++V A+D D G N ++ YSI+SGN F +DA +G + + LDYE T Y+L
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
Query: 1861 IVQATDKGMPRLSNTT-VIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDV 1918
V+A D G P LSN + ++ VQV DINDNAP F+ + +S+P G +V HV D
Sbjct: 473 RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 1919 DL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYT-- 1974
D N+ + A + F I+ TG + + LD EE+ Y ++ D H T
Sbjct: 533 DAGDNARLEYRLAGVGHD-FPFTINNGTGWISVAAELDREEVDFYSFGVEARD--HGTPA 589
Query: 1975 ---EGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILS 2031
++ V VLDVNDN P F+Q Y V + E VG SV+T+SA D +++ I+Y+I S
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITS 649
Query: 2032 SS--KEFSIDPKNGTIFTISPVLLLDTISTTQFL--VEASDGGNPDLRALTLVEIGIEDM 2087
+ FSI ++G +S L LD Q++ V ASDG D + + + D
Sbjct: 650 GNTRNRFSITSQSGGGL-VSLALPLDYKLERQYVLAVTASDGTRQDTAQIV---VNVTDA 705
Query: 2088 NNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
N + P F Y ++++ED G+T+V S D D T EN + Y + Q +T
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITYFMEDSIPQFRIDADT 764
Query: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
G + LD E S+ L I A D+G P S T + I V DVNDN
Sbjct: 765 ------------GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNA 812
Query: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE-KGHFYLEENTGV 2266
P F SY V E P + + +SA DRD+G + + Y G++ G F +E +G+
Sbjct: 813 PQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGI 872
Query: 2267 LYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPE 2325
+ ++ LD E + ++ L A D + V V+VLD ND+ P F F V E
Sbjct: 873 VRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEE 932
Query: 2326 NLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQIL 2385
N PI + + A D D G ++ Y IV ++F +D +G++ A L
Sbjct: 933 NSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI--------PEVFQLDIFSGELTALVDL 984
Query: 2386 DYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQL-- 2443
DYE+ +Y L +QA + V V + ++ P+ + F N+
Sbjct: 985 DYEDRPEYVLVIQATS-APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
Query: 2444 --IGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486
IGRV A D D + G +N + G + L RAL
Sbjct: 1044 GAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
Score = 315 bits (806), Expect = 5e-85
Identities = 292/982 (29%), Positives = 448/982 (45%), Gaps = 82/982 (8%)
Query: 1371 APEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYH---IIDGNTDECFTINEM 1426
AP+F SY V ENQ V ++ A D D G +EY + D +++ F+++ +
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 1427 SGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSS 1486
+G ++T LDRE S + D G P RS++ L + V D NDH P F Y+ S
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA----FTIDPMSGTLKTSNTLDR 1542
+RE+ EVG VL + A D D N Y L + + G+ F IDP SG ++T +DR
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
Query: 1543 EARSQHTFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQT 1601
E + + A D G RSTT + + V D NDN P + + V + +
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAP 417
Query: 1602 TVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQ----FQQNPSSEYFPIWLQL 1655
+ V A D D G N V +S + F +D TG + + EY L++
Sbjct: 418 VLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT---LRV 474
Query: 1656 KVTDQGIPARTT-TGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS 1713
+ D G P + +GL+ + ++ D F ++ V E+ G ++ V+A D+
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 1714 IQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAY-- 1770
++ ++Y + D ++ + +G ++V LD E + V A G A
Sbjct: 535 GDNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTA 592
Query: 1771 -CKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSG 1829
V+V + D NDN+P F Q Y ++E V+ V A D D+ + +I Y I SG
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG 650
Query: 1830 NQEEAFQIDALSG--VITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIND 1887
N F I + SG +++ LDY+L Y L V A+D +T I V VTD N
Sbjct: 651 NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVTDANT 707
Query: 1888 NAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTG 1945
+ P F S V + ED G V +S D D +A I F ++S P +F ID +TG
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP--QFRIDADTG 765
Query: 1946 VVVLVKTLDFEEMTEYELLI--------QISDSVHYTEGALVVRVLDVNDNPPVFSQDFY 1997
V LD+E+ Y L I Q SD+ + L + V DVNDN P F +D Y
Sbjct: 766 AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY-----LEILVNDVNDNAPQFLRDSY 820
Query: 1998 QVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSK---EFSIDPKNGTIFTISPVL 2052
Q +V E +P SVL +SATD +S N + Y +F ++ +G + T+
Sbjct: 821 QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRR-- 878
Query: 2053 LLDTISTTQFLVEAS--DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110
LD + Q+++ A D G P R V + + D+N+ P F +++ + E++ +G
Sbjct: 879 -LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
Query: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
+ + D D N + Y I+ GN F ++ F E L L LD
Sbjct: 938 LAVARVTATDPD-EGTNAQIMYQIVEGNIPEVFQLD--IFSGE--------LTALVDLDY 986
Query: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP---NFSSL--SYHTHVKESTPL 2225
E + LVI A+ + PL S A + +++LD NDNPP NF L +Y T+ S P
Sbjct: 987 EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP- 1042
Query: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
G I V A+D D + Y+ GNE L +TG L L + LD + + ++V
Sbjct: 1043 GGAIGRVPAHDPDISD--SLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
Query: 2286 QASDAEKKHFSFAVVFVSVLDD 2307
SD + + V+++ D
Sbjct: 1101 LVSDGVHSVTAQCALRVTIITD 1122
Score = 308 bits (790), Expect = 4e-83
Identities = 287/994 (28%), Positives = 432/994 (43%), Gaps = 88/994 (8%)
Query: 376 EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS----EPIFYRISSGDLGGKFSIHPRLG 431
+F+ P Y V E+ P +P+ +++A +P E + FS+ P G
Sbjct: 180 QFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTG 239
Query: 432 TIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRIS 490
+ T + LD ET+ V V AQ P S+ + I V D ND+ P F + + +
Sbjct: 240 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
Query: 491 QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGE 546
+ G + RA D D+ N I Y + G VF ID GV+ G + E
Sbjct: 300 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 547 QRELTLTLRAEDQGVHP---QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQ 603
LT+ A DQG P V V + +++P F Y V+V E ++P
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ--FSEKRYVVQVREDVTPGAP 417
Query: 604 MLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA 663
+L+ A + + + + YS+ F + TG + + DYE+T+ Y RV A
Sbjct: 418 VLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
Query: 664 WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSG 722
L NVS V V+V D NDN+P F+ V ES VP G ++ + AID D+G
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLES-VPLGYLVLHVQAIDADAG 535
Query: 723 KNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782
N +L Y L G F N G W AA
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTG-------WISVAAE--------------------- 567
Query: 783 FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 842
LDRE + V D G+P A+ +V V+V D+NDN P F Q
Sbjct: 568 --------------LDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ- 612
Query: 843 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRT 902
E V++ E V V TV A D D ++ +TY ++S ++ + F I + +G
Sbjct: 613 ---PEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLV 667
Query: 903 TTILSYDYR--PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPEN 960
+ L DY+ Y ++V A+D G Q VVN V + R + + + + E+
Sbjct: 668 SLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNVNED 724
Query: 961 LKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY 1020
+ LI ++D + + +D F ID+ TG + ELDYE Y
Sbjct: 725 RPAGTTVVLISATD---EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSY 781
Query: 1021 LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ D+ S T +L I V D ND++P F + SV E+VP T V +A
Sbjct: 782 TLAITARDNGIP-QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
Query: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
D D S LN R+ Y + + G F++ + G + T+ RLDRE++ +L A D+ +
Sbjct: 841 DRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGM- 898
Query: 1141 VTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKV 1199
+ + +LDVND+ P F + V+E+ +G V +TA DPDEG N ++
Sbjct: 899 --PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQI 956
Query: 1200 TYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTV 1259
Y I+ GN F LD SG LT LDYE + +++L + A + L S T+ V +
Sbjct: 957 MYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRL 1013
Query: 1260 LDVNDEAPVFK--QHLYEASV--KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE 1315
LD ND PV + L+ V + + PG + RV A D D ++ L + G
Sbjct: 1014 LDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELS 1071
Query: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDG 1349
L +N+ TGE+ + LD + VLV DG
Sbjct: 1072 LVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Score = 304 bits (778), Expect = 1e-81
Identities = 271/996 (27%), Positives = 436/996 (43%), Gaps = 91/996 (9%)
Query: 478 PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA----SPQPGVFAIDRAL 533
P F S + + + P GT + RA D D G G + Y++ S F++D
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 534 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQV 592
G + L + + A+D G+ ++AL LT+++ + +H P FE Y+
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP--VFEQQEYKE 296
Query: 593 EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS--VDSAMFGIRPYTGWIYLRRQFD 650
+ E+L ++L +A A+ L LE S S +F I P +G I R D
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 651 YESTQTYNFRVFAWIP-EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG 709
E ++Y V A D ++ + V + V D+NDN+P F ++V E P
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
Query: 710 VIGKITAIDMDSGKNGQLLYFLLSD---GKFFKMNPNTGPAGTIYVITWADGAAAFSGTD 766
+ ++TA D D G N + Y ++S G+F+ ++ TG +
Sbjct: 417 PVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTGALDVVS--------------- 460
Query: 767 FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPP-RNATMAV 825
LD E + + V D G PP N + V
Sbjct: 461 -----------------------------PLDYETTKEYTLRVRAQDGGRPPLSNVSGLV 491
Query: 826 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE 885
V V DINDN P F VLE P+ LV V A D D G+NA + Y ++
Sbjct: 492 TVQVLDINDNAPIFVST----PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
Query: 886 DSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945
F I+ G I L + Y V A D G P L A V++ V+ ++
Sbjct: 548 GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN 607
Query: 946 AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005
+Q + + E+ + + + D + + + + I + + F I S +G
Sbjct: 608 PTFTQPEYTVRLNEDAAVGTSVVTVSAVD---RDAHSVITYQITSGNTRNRFSITSQSGG 664
Query: 1006 --LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVIS 1063
+ L+ LDY+ Y+ V +D ++ T + ++V D N H P FQ ++
Sbjct: 665 GLVSLALPLDYKLERQYVLAVTASDGTRQ----DTAQIVVNVTDANTHRPVFQSSHYTVN 720
Query: 1064 VEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRE 1123
V E+ P GT V + +A D+D N+RI Y++E P F I G + T + LD E
Sbjct: 721 VNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIP---QFRIDADTGAVTTQAELDYE 776
Query: 1124 SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSL 1182
+ L +TA D + ++ + +I++ DVND+ P F+ V EDV +
Sbjct: 777 DQVSYTLAITARDNGI---PQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
Query: 1183 VHHITAHDPDEGRNGKVTYSILSGNE-NMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
V I+A D D G NG+V Y+ G++ + F+++ +SG++ T LD E Q++L A
Sbjct: 834 VLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
Query: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
+D G P + +TVTVLDVND PVF+Q ++ V+EN G V RV A D D G N
Sbjct: 894 VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
Query: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
+++ ++I+ G E+F+++ +GE+ LD E + + VLV L S T+
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---VLVIQATSAPLVSRATVH 1010
Query: 1362 CTVEDENDHAP-----EFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGN 1416
+ D ND+ P E + ++Y + + V A D D + ++ Y GN
Sbjct: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISD--SLTYSFERGN 1068
Query: 1417 TDECFTINEMSGELSTTRALDREQISNFTLVILCSD 1452
+N +GEL +RALD + + +L SD
Sbjct: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 287 bits (735), Expect = 9e-77
Identities = 217/730 (29%), Positives = 347/730 (47%), Gaps = 51/730 (6%)
Query: 1782 DNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY---SILSGNQEEAFQID 1838
+ +P F+ YQA+V E+Q V + A D D G G +EY ++ + F +D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 1839 ALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV 1898
++G +TT LD E S++ V A D GMPR S + + VTD ND+ P F E
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 1899 EITEDSLP---GVIVTHVSVHDVDLNSAFIFSFAKES--NPGTKFAIDQNTGVVVLVKTL 1953
E ++L V+ + D N+ ++ + S +P F ID +GV+ +
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 1954 DFEEMTEYELLIQISD-----SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVG 2008
D EE+ Y+L ++ SD T A+ + V D NDN P FS+ Y V V E + G
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 2009 YSVLTLSATDLE--SNENISYRILSSSK--EFSIDPKNGTIFTISPVLLLDTISTTQFLV 2064
VL ++A+D + SN + Y I+S + +F +D + G + +SP L +T V
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP-LDYETTKEYTLRV 474
Query: 2065 EASDGGNPDLRALT-LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW 2123
A DGG P L ++ LV + + D+N+ AP F + ++ E +G ++ ID D
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD- 533
Query: 2124 TRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILAS 2183
+N +EY + F + G++ + LDRE + + A
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTIN----------NGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 2184 DSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHA 2243
D G P L+++A +S+ VLDVNDN P F+ Y + E +G+ + VSA DRD +H+
Sbjct: 584 DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHS 641
Query: 2244 EIIYNIISGNEKGHFYL--EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF 2301
I Y I SGN + F + + G++ L PLDY+ ++ L V ASD ++ A +
Sbjct: 642 VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ--DTAQIV 699
Query: 2302 VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTH 2361
V+V D N H P F S ++ V E+ P +T+ I+A D D G +TY
Sbjct: 700 VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYF--------- 750
Query: 2362 GMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDI--EGID 2419
M F ID TG + + LDYE+ Y L + A+D G S +++I ++
Sbjct: 751 -MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVN 809
Query: 2420 EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL---GTSSPFFSVNKT 2476
+ P F +D Y ++ E + ++ A+D D+G++G + Y+ F V T
Sbjct: 810 DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
Query: 2477 NGNIYLIRAL 2486
+G + +R L
Sbjct: 870 SGIVRTLRRL 879
Score = 261 bits (667), Expect = 7e-69
Identities = 261/953 (27%), Positives = 410/953 (43%), Gaps = 90/953 (9%)
Query: 327 GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386
G + L +T V+AQD G A +TI + T FE+ +Y +
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 387 YEDVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTRKPLD 440
E++ + TV+A + P N++ I YR+ G G F I PR G IRTR P+D
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNAN--ILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 441 HETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497
E LTV+A P ++ V ++V D NDN P F +++ + PG
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
Query: 498 ALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 556
+ A DRD G N ++ YSI S G F +D G L + L +E TL +RA
Sbjct: 417 PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
Query: 557 EDQGVHPQAAL--LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 614
+D G P + + LV V++ +++P F +Q V ES+ +L QA
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAP--IFVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 615 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 674
A L Y L F I TGWI + + D E Y+F V A L
Sbjct: 535 GDNAR-LEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL-TA 592
Query: 675 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 734
S +V V V D NDN+PTF +++ E + ++A+D D+ + + Y + S
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITS- 649
Query: 735 GKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINW 794
G + IT G S
Sbjct: 650 ----------GNTRNRFSITSQSGGGLVS------------------------------- 668
Query: 795 VALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE 854
+AL +++ + + VT R T + V+VTD N +RP F V V E
Sbjct: 669 LALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANTHRPVF----QSSHYTVNVNE 723
Query: 855 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSY 914
+P V + A D D G NA +TY + EDS F+IDA+ G + T L Y+ + SY
Sbjct: 724 DRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDADTGAVTTQAELDYEDQVSY 781
Query: 915 RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974
+++ A D G+P + I V ++ ++ + E++ P + I ++D
Sbjct: 782 TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 975 HLQQHYNGKLHFSIV-ADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL 1033
NG++ ++ DD DG F ++S++G + + LD E + Y+ R D K +
Sbjct: 842 R-DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVD--KGM 898
Query: 1034 SLSST-VFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ T + +++ V D ND+ P F+ + + VEEN PIG V A D D N++I
Sbjct: 899 PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG-TNAQIM 957
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Y I N F + G L + LD E P +L + A+ + + T
Sbjct: 958 YQIVEGNI-PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPL------VSRATVH 1010
Query: 1153 IVILDVNDHNPTFISFP---NAHV--KEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN 1207
+ +LD ND+ P +F N +V + G + + AHDPD + +TYS GN
Sbjct: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGN 1068
Query: 1208 ENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL 1260
E +L+ S+G L + LD + I++VL + DG ++++ L VT++
Sbjct: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVL-VSDGVHSVTAQCALRVTII 1120
Score = 228 bits (581), Expect = 7e-59
Identities = 253/1008 (25%), Positives = 419/1008 (41%), Gaps = 120/1008 (11%)
Query: 81 ASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAK 140
A D D G G +EY++ D + Q F +DP G + ++++DRE +T+ V A+
Sbjct: 205 AIDPDEGEAGRLEYTM-DALFDSRSNQFFSLDPVTGAVTTAEELDRETK-STHVFRVTAQ 262
Query: 141 DGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL 200
D R SA A + + + D ND+ PVF Y S+ + + G E++ V
Sbjct: 263 DHGMPRR----------SALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVR 312
Query: 201 ATDQDSGIYGTVAYELIP---GNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLE 257
ATD D+ + Y L+ G+ S +F ID +G+ + D+E + S +
Sbjct: 313 ATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV--------DREEVESYQ 364
Query: 258 MFLPLLRH-------------FKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDE 304
+ + F VE D + A + E +R L+V
Sbjct: 365 LTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTAS 424
Query: 305 AASADGEAAARYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGG-GLT 356
A Y G+ G + + PL + + +L V AQDGG
Sbjct: 425 DRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPL 484
Query: 357 AVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRI 415
+ ++ VT+ + F + V E VP + V+A + + + YR+
Sbjct: 485 SNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL 544
Query: 416 SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA-CSSTEVNITVMDVN 474
+ F+I+ G I LD E V+A+ PA +S V++TV+DVN
Sbjct: 545 AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVN 604
Query: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAI--DR 531
DN+P F + +R+++ GT++ A DRD+ + +I Y I S F+I
Sbjct: 605 DNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQS 662
Query: 532 ALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQ 591
G++ L L +R+ L + A D G A +V+ V + H P + H Y
Sbjct: 663 GGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVT-DANTHRPVFQSSH--YT 718
Query: 592 VEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDY 651
V V+E T ++ A A + Y +E S+ F I TG + + + DY
Sbjct: 719 VNVNEDRPAGTTVVLISATDEDTGENAR-ITYFMEDSI--PQFRIDADTGAVTTQAELDY 775
Query: 652 ESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGV 710
E +Y + A ++G Q TT + + V D NDN+P FL D V E P
Sbjct: 776 EDQVSYTLAITA--RDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTS 833
Query: 711 IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFS 770
+ +I+A D DSG NG++ Y F G D
Sbjct: 834 VLQISATDRDSGLNGRVFY-------------------------------TFQGGD---- 858
Query: 771 SDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 830
D F+++S G + LDRE+ + + D+G PP M V V+V
Sbjct: 859 -DGDGDFIVEST-----SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
Query: 831 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH 890
D+NDN P F Q E V V E P+ + V V A DPDEG NA++ Y + + +
Sbjct: 913 DVNDNPPVFEQ----DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 968
Query: 891 FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI------PLSKG 944
F++D +GE+ L Y+ RP Y + + AT PL +A V+++++ P+
Sbjct: 969 FQLDIFSGELTALVDLDYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGN 1025
Query: 945 RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTG 1004
I+ N ++ + P + + + D + L +S ++ +++STG
Sbjct: 1026 FEILFNN--YVTNRSSSFPGGAIGRVPAHD---PDISDSLTYSFERGNELSLVLLNASTG 1080
Query: 1005 DLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052
+L LS+ LD + V+ +D +++ + ++I ++ HS
Sbjct: 1081 ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHS 1128
Score = 227 bits (579), Expect = 1e-58
Identities = 186/565 (32%), Positives = 278/565 (49%), Gaps = 44/565 (7%)
Query: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNE--NISYRILS-----SSKEFSIDPKN 2042
P F YQ TVPE+ P G V +L A D + E + Y + + S++ FS+DP
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2043 GTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLS 2102
G + T + L +T ST F V A D G P AL + I + D N++ P F + Y S
Sbjct: 239 GAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 2103 LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYL 2162
L E+ VG ++T D D N + Y ++ G+ + V F + + G +
Sbjct: 298 LRENLEVGYEVLTVRATDGD-APPNANILYRLLEGSGGSPSEV----FEID---PRSGVI 349
Query: 2163 VLLHSLDREASASHELVILASDSGCPP--LSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
+DRE S++L + ASD G P S+TA + + V D NDN P FS Y V+
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK 2280
E G+ + V+A+DRD GS+A + Y+I+SGN +G FYL+ TG L ++ PLDYE +
Sbjct: 410 EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469
Query: 2281 FTLTVQASDAEKKHFS--FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINA 2338
+TL V+A D + S +V V VLD ND+AP F+ + F V E++P+ + + A
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529
Query: 2339 LDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQ 2398
+D DAG L Y + G+ +D F I+ TG I LD E + Y V+
Sbjct: 530 IDADAGDNARLEYRLA-------GVGHDFP-FTINNGTGWISVAAELDREEVDFYSFGVE 581
Query: 2399 AKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGI 2456
A+D G TAS V V + +++ P FTQ +Y L E + V A D DA
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA-- 639
Query: 2457 DGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMK-IIAHSPKSDSK 2513
VI Y + G + FS+ +G + ALPL + LE + ++A + ++
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLALPL-------DYKLERQYVLAVTASDGTR 692
Query: 2514 FASCTVFVNVSFSSEGTPLAVFASS 2538
+ + VNV+ ++ P VF SS
Sbjct: 693 QDTAQIVVNVTDANTHRP--VFQSS 715
Score = 201 bits (512), Expect = 7e-51
Identities = 224/881 (25%), Positives = 360/881 (40%), Gaps = 91/881 (10%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
V A+D D+ I Y L +G S +P + F IDP G I +DRE + +Y L V
Sbjct: 311 VRATDGDAPPNANILYRLLEG--SGGSPSEVFEIDPRSGVIRTRGPVDRE-EVESYQLTV 367
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
EA D G S A V + +ED NDN P F+ YV + ++ PG ++
Sbjct: 368 EASDQGRD--------PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
Query: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEV---MN 254
V A+D+D G V Y ++ GN F +D+ TG ++++S +++ KE +
Sbjct: 420 RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYETTKEYTLRVR 475
Query: 255 SLEMFLPLLRHFK---KVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE 311
+ + P L + V+ + S + L YL + +A AD
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 312 AAARYVANLAKI---------LGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD 362
AR LA + G G I + L E S V A+D G +A
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS 595
Query: 363 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG 422
V++ + F +P+YT + ED + + TV A + ++ I Y+I+SG+
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDR-DAHSVITYQITSGNTRN 654
Query: 423 KFSIHPRLG--TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480
+FSI + G + PLD++ + VL V A G+ + VN+T D N + P F
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVT--DANTHRPVF 712
Query: 481 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540
+ + +++ P GT + L A D D+G N I Y + P F ID G +
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FRIDADTGAVTTQA 771
Query: 541 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLS 599
L +Q TL + A D G+ ++ L +++ + +++P + + YQ V E +
Sbjct: 772 ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS--YQGSVYEDVP 829
Query: 600 PMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS-AMFGIRPYTGWIYLRRQFDYESTQTYN 658
P T +LQ A + Y+ + D F + +G + R+ D E+ Y
Sbjct: 830 PFTSVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYV 888
Query: 659 FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718
R +A + + V V V D NDN P F D + VEE+ + ++TA D
Sbjct: 889 LRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 719 MDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV 778
D G N Q++Y ++ G I + D
Sbjct: 948 PDEGTNAQIMYQIVE--------------GNIPEVFQLD--------------------- 972
Query: 779 LKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838
+ GEL V LD E R + VLV S P + V+V + D NDN P
Sbjct: 973 -------IFSGELTALVDLDYEDRPEY---VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
Query: 839 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG 898
+V + V A DPD ++ +TYS + ++A+ G
Sbjct: 1023 LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTG 1080
Query: 899 EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI 939
E++ + L + MSV+ +D GV + Q + + +I
Sbjct: 1081 ELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
Score = 194 bits (492), Expect = 1e-48
Identities = 231/1001 (23%), Positives = 396/1001 (39%), Gaps = 102/1001 (10%)
Query: 175 PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY---ELIPGNVSSLFTIDSTT 231
P F P +Y ++ + GT + ++ A D D G G + Y L + F++D T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 232 GLYSPEVEILSAVNFSADKEVMNSLEMFLP---LLRHFKKVERDEEAAEKKFEASRGWFM 288
G + E L S + + + +P L + D + FE + +
Sbjct: 239 GAVT-TAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE-QQEYKE 296
Query: 289 RFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILG------------EGIIYLTLPLS 336
+ + Y + A D A + L + G G+I P+
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 337 HLESTTLSLMVSAQDGGGLTA--VINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 394
E + L V A D G A V + + +F +Y V EDV +
Sbjct: 357 REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416
Query: 395 PIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA 453
P+ V A + S+ + Y I SG+ G+F + + G + PLD+ET L V+A
Sbjct: 417 PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476
Query: 454 QLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
Q G P S+ V + V+D+NDN P F+ T + + ++ P G + +A D D+G
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
Query: 512 NGLIRYSIAS-PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAALLV 569
N + Y +A F I+ G + + L E + + A D G A+ V
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
Query: 570 LTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSV 629
V++ +++P TF Y V ++E + T ++ A + A S + Y +
Sbjct: 597 SVTVLDVNDNNP--TFTQPEYTVRLNEDAAVGTSVVTVSA---VDRDAHSVITYQITSGN 651
Query: 630 DSAMFGIRPYT--GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 687
F I + G + L DY+ + Y V A DG Q+ + ++V V D N
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQY---VLAVTASDGTRQD-TAQIVVNVTDANT 707
Query: 688 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPA 747
+ P F + V E + I+A D D+G+N ++ YF+ F+++ +TG
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGA- 766
Query: 748 GTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEM 807
V T A+ LD E + + +
Sbjct: 767 ----VTTQAE---------------------------------------LDYEDQVSYTL 783
Query: 808 TVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFA 867
+ D G P ++ T + + V D+NDN P F + V E P V + A
Sbjct: 784 AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLR----DSYQGSVYEDVPPFTSVLQISA 839
Query: 868 KDPDEGNNAEVTYSVSSEDSSD-HFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP 926
D D G N V Y+ D D F +++ +G +RT L + Y + A D+G+P
Sbjct: 840 TDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP 899
Query: 927 PLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHF 986
P + V + V+ ++ + Q+ + + EN ++ + ++D + N ++ +
Sbjct: 900 PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDP-DEGTNAQIMY 958
Query: 987 SIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVE 1046
IV + F++D +G+L +LDYE Y+ + T + L S + + +
Sbjct: 959 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT----SAPLVSRATVHVRLL 1014
Query: 1047 DQNDHSPSFQDELI-----VISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPG 1101
D+ND+ P + I V + + P G + V A D D ++ + Y E N
Sbjct: 1015 DRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRV-PAHDPD---ISDSLTYSFERGNE- 1069
Query: 1102 TNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVT 1142
+ L++ S G L LD I++V SD +VT
Sbjct: 1070 LSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVT 1110
Score = 61.2 bits (147), Expect = 1e-08
Identities = 46/165 (27%), Positives = 77/165 (46%), Gaps = 18/165 (10%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+++A+D DSGL G + Y+ G + F ++ G + + +DRE + A Y L
Sbjct: 836 QISATDRDSGLNGRVFYTFQGGD---DGDGDFIVESTSGIVRTLRRLDRE-NVAQYVLRA 891
Query: 138 EAKDGDEQRMTHLALVKGGLSAQA--FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
A D KG A+ V V + DVNDN PVF + + + + G
Sbjct: 892 YAVD------------KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
+ V ATD D G + Y+++ GN+ +F +D +G + V++
Sbjct: 940 VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDL 984
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 363 bits (931), Expect = 2e-99
Identities = 271/864 (31%), Positives = 419/864 (48%), Gaps = 38/864 (4%)
Query: 796 ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 855
ALDRE H + V D GSP +AT V V+V D ND+ P F Q + L V EG
Sbjct: 390 ALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEG 449
Query: 856 QPVNMLVTTVFAKDPDEGNNAEVTYS-----VSSEDSSDHFKIDANNGEIRTTTILSYDY 910
P+ L T D D NA + Y + ++ F+ID +G I T+ + ++
Sbjct: 450 YPILQLRAT----DGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH 505
Query: 911 RPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI--IPENLKPTKIMS 968
SY + V A+DQG P A V + + L + + + + + E+++P ++
Sbjct: 506 MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVL 565
Query: 969 LIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTD 1028
+ ++D + NG +H++I++ + GHF IDS TG++ + LD+E Y R+ D
Sbjct: 566 RVTATDR-DKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQD 624
Query: 1029 HSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLN 1088
+ ++T SI V D NDH P F +SV EN P+G V A D D N
Sbjct: 625 AGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG-EN 683
Query: 1089 SRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRS 1148
+R++Y + P T PF+I+ + G + LDRES+ V A D + S
Sbjct: 684 ARLEYSLTGVAPDT-PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG---SPPLSAS 739
Query: 1149 LTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN 1207
+ + +LDVND+ P F + + + ED VG+ V +TA D D N ++Y I GN
Sbjct: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN 797
Query: 1208 ENMTFMLDESS--GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
F + GL+T PLDY+ + L + A D AL + + + D N
Sbjct: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTH 854
Query: 1266 APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGE 1325
PVF+ Y SV E++ G + + A D D G N+++ + + + F I++D+G
Sbjct: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRIDADSGA 912
Query: 1326 VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE 1385
+ LD E Q +TL + RD G P + TT + V D ND+AP+F+ S Y V E
Sbjct: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
Query: 1386 NQEP-EVVYTVLASDMDAGNNRAVEYHIIDG-NTDECFTINEMSGELSTTRALDREQISN 1443
+ P V + A+D DA N V+Y +G + D FTI SG + T R LDRE +S
Sbjct: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSV 1032
Query: 1444 FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAV 1503
+ L D G PP + + +QV V D ND++P FP ++ V+E++ VG+VV ++AV
Sbjct: 1033 YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAV 1092
Query: 1504 DKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS 1562
D DEG N Y + + F +D SG L LD EAR ++ A + S
Sbjct: 1093 DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLV-S 1151
Query: 1563 RSTTVIIKVYVTDVNDNDPVLE--QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
R+T + V + D NDN PVL Q F+ ++S S T + +I R D + + +
Sbjct: 1152 RAT---VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFY 1208
Query: 1621 SF--AETQSMFSIDKYTGEIQFQQ 1642
SF + +++ +GE++ +
Sbjct: 1209 SFERGNELQLLVVNQTSGELRLSR 1232
Score = 362 bits (928), Expect = 4e-99
Identities = 285/949 (30%), Positives = 446/949 (46%), Gaps = 65/949 (6%)
Query: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT----DEASGAFT 1526
AN H P FP YQ+ V E+ GT VL + A D D G G+ Y L + F+
Sbjct: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 1527 IDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSR--STTVIIKVYVTDVNDNDPVLE 1584
IDP SG ++T+ LDRE+ +H A+D GS S T ++ V V D ND+ PV E
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQD---HGSPRLSATTMVAVTVADRNDHSPVFE 434
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-------AETQSMFSIDKYTGE 1637
Q + L + +RA D D PN + + F A + F ID +G
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 1638 IQFQQNPSSEYFPIW-LQLKVTDQGI---PARTTTGLLVIHMEGEDVKISFSHHLYKGLV 1693
I E+ + L ++ +DQG P T + + ++ D FS Y V
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
Query: 1694 TENCEAGTSIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV 1752
E+ T ++ V A D + + Y+I SGN G ++ S +G++ V P LDFE
Sbjct: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP--LDFEA 612
Query: 1753 RNEVQLIVLAESSGHRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
E L + A+ +G ++ + D ND+ P F + +Q SV E+ VI
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
+ A D D G N +EYS+ + F I++ +G ++ LD E Y V+A D G
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
Query: 1869 MPRLSNTTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVDLNSAFIFS 1927
P LS + + V V D+NDN P F E + + ED+ G V V+ D D NSA +
Sbjct: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQ 792
Query: 1928 FAKESNPGTKFAIDQNTGV--VVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDV 1985
N +FAI GV V L LD+++ ++L++ SD + + + + D
Sbjct: 793 ITG-GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDA 851
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNG 2043
N + PVF Y V+V E P+G +++ +SA+D + EN I+Y + + +F ID +G
Sbjct: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSG 911
Query: 2044 TIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSL 2103
I +P+ D ++ T + A D G P T VE+ + D+N+ AP+F Y +
Sbjct: 912 AITLQAPLDYEDQVTYT-LAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
Query: 2104 SEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEYPYKQVGYL 2162
SEDA ++++ S D D N V+Y+ +G + +F +E G +
Sbjct: 971 SEDAPPFTSVLQISATDRD-AHANGRVQYTFQNGEDGDGDFTIEPTS----------GIV 1019
Query: 2163 VLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222
+ LDREA + +EL A D G PPL + I + V DVNDN P F + + VKE+
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
Query: 2223 TPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282
+ +GS + ++A D D G +A I+Y I+ GN F ++ +G L + LDYE ++
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
Query: 2283 LTVQASDAEKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLPISSTICSIN 2337
+ VQA+ A S A V V ++D ND++P Q +F+++ + P S I I
Sbjct: 1140 IVVQATSAPL--VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP-SGIIGRIP 1196
Query: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILD 2386
A D D + F + + L +++ +G++ + LD
Sbjct: 1197 AYDPDVSDH----------LFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
Score = 357 bits (916), Expect = 1e-97
Identities = 282/907 (31%), Positives = 442/907 (48%), Gaps = 38/907 (4%)
Query: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQ 1056
F ID +G + + LD E+ + RV DH LS+T +++ V D+NDHSP F+
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFE 434
Query: 1057 DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYI----ESHNPGTNPFLIHPSFG 1112
++ ENV G + A D D N+ ++Y + F I P G
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAP-PNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-A 1171
+ T R+DRE + + L V ASDQ R ++ I +LD ND+ P F A
Sbjct: 494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSA-TVRVHITVLDENDNAPQFSEKRYVA 552
Query: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEM 1231
V+EDV ++V +TA D D+ NG V Y+I+SGN F +D +G + PLD+E
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 1232 KTQHILTVLALDDGTPALSSSQTL-TVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ ++ L + A D G P LS++ L ++ V+D+ND P+F ++ SV EN G V
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
++A+D D G N++L++ + A F INS TG V + LDRE E + V RD G
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRA 1407
P LS++ ++ TV D ND+ PEF + Y + + N++ V V +V A D DA N A
Sbjct: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRL--NEDAAVGTSVVSVTAVDRDA--NSA 788
Query: 1408 VEYHIIDGNTDECFTINEMSGELSTTRA--LDREQISNFTLVILCSDLGDPPRSSVIHLQ 1465
+ Y I GNT F I+ G T A LD +Q F LV+ SD ++
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVH 845
Query: 1466 VRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAF 1525
+ + DAN H P F + +Y SV ED +G+ ++V+SA D D G N + Y L D F
Sbjct: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLP-QF 904
Query: 1526 TIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQ 1585
ID SG + LD E + +T + ARD I ++ T ++V V DVNDN P
Sbjct: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDNAPQFVA 963
Query: 1586 NPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF---AETQSMFSIDKYTGEIQFQQ 1642
+ + +S ++P + + + A D D NG V ++F + F+I+ +G ++ +
Sbjct: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
Query: 1643 NPSSEYFPIW-LQLKVTDQGI-PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG 1700
E ++ L D+G+ P RT + V+ + D F ++ V EN G
Sbjct: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
Query: 1701 TSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLI 1759
+ + + A PD ++ + Y I GN + + SG+LT LD+E R E ++
Sbjct: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALID--LDYEARQEYVIV 1141
Query: 1760 VLAESSGHRAYCKVAVLIQDENDNSPCFE--QSIYQASVS-ESQLYNAHVI-QVFATDLD 1815
V A S+ + V V + D+NDNSP Q ++ VS S + + +I ++ A D D
Sbjct: 1142 VQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
Query: 1816 SGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNT 1875
++ + YS GN+ + ++ SG + LD S++V TD G+ ++
Sbjct: 1202 --VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQ 1258
Query: 1876 TVIKVQV 1882
V++V +
Sbjct: 1259 CVLRVVI 1265
Score = 355 bits (912), Expect = 3e-97
Identities = 260/854 (30%), Positives = 425/854 (49%), Gaps = 37/854 (4%)
Query: 1267 PVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI---MPGASFELFEINSDT 1323
P F Q+ Y+ V EN+ G V RV A D D+G +L + + M S ELF I+ +
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
G + T LDRE E LRV +D G P LS+TT + TV D NDH+P F + Y +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 1384 LEN-QEPEVVYTVLASDMDAGNNRAVEYHIID-----GNTDECFTINEMSGELSTTRALD 1437
EN +E + + A+D DA N + Y + F I+ SG +ST+ +D
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
Query: 1438 REQISNFTLVILCSDLGDP--PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGT 1495
RE + ++ LV+ SD G PRS+ + + + VLD ND++P F Y + VRED T
Sbjct: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
Query: 1496 VVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
VVL ++A D+D+ NG Y ++ + G F ID ++G ++ LD EA ++ A
Sbjct: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRA 622
Query: 1555 RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGP 1614
+D + T + + V D+ND+ P+ PF V + +P + + ++A D D G
Sbjct: 623 QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGE 682
Query: 1615 NGTVVFSF--AETQSMFSIDKYTGEIQFQ---QNPSSEYFPIWLQLKVTDQGI-PARTTT 1668
N + +S + F I+ TG + S E++ + ++ D G P +
Sbjct: 683 NARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY--FFGVEARDHGSPPLSASA 740
Query: 1669 GLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNED 1728
+ V ++ D + F+ Y + E+ GTS+V+V A D+ ++ Y I GN
Sbjct: 741 SVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA-NSAISYQITGGNTR 799
Query: 1729 GVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFE 1788
++ ++ G V LD++ +L++ A +C V + I D N + P F+
Sbjct: 800 NRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQ 859
Query: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKA 1848
+ Y SV+E + + ++ + A+D D G N I Y +L N + F+IDA SG IT +A
Sbjct: 860 SAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQ-FRIDADSGAITLQA 917
Query: 1849 ILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVE-ITEDSLPG 1907
LDYE +Y+L + A D G+P+ ++TT ++V V D+NDNAP F+ S ++ED+ P
Sbjct: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
Query: 1908 VIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLI 1965
V +S D D N ++F + F I+ +G+V V+ LD E ++ YEL
Sbjct: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
Query: 1966 QISD---SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES- 2021
D T ++ V V DVNDN PVF + ++V V E+ VG V ++A D +
Sbjct: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG 1097
Query: 2022 -NENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078
N +I Y+I+ + + F +D +G ++ ++ LD + ++++ P L +
Sbjct: 1098 PNAHIMYQIVEGNIPELFQMDIFSG---ELTALIDLDYEARQEYVIVVQATSAP-LVSRA 1153
Query: 2079 LVEIGIEDMNNYAP 2092
V + + D N+ +P
Sbjct: 1154 TVHVRLVDQNDNSP 1167
Score = 330 bits (845), Expect = 2e-89
Identities = 273/930 (29%), Positives = 424/930 (45%), Gaps = 44/930 (4%)
Query: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDH 890
+ P FPQ V E + V V A+DPD G + YS+++ S +
Sbjct: 320 NRHPQFPQY----NYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
Query: 891 FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQ 950
F ID +G IRT L + + + V A D G P L +V + V + + Q
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 951 NIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD-----KDGHFEIDSSTGD 1005
+ EN++ + ++++D N L + V FEID +G
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDG-DAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 1006 LFLSKELDYETTSHYLFRVITTDHSKNLS-LSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
+ S +D E Y V +D + S+TV + I V D+ND++P F ++ V V
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
Query: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
E+V T+V A D D N + Y I S N F I G + V+ LD E+
Sbjct: 555 REDVRPHTVVLRVTATDRDKD-ANGLVHYNIISGN-SRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 1125 IPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLV 1183
L + A D + A I ++D+NDH P F+S P V E+ +G V
Sbjct: 613 EREYALRIRAQDAGRPPLSN--NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
Query: 1184 HHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD 1243
HI A D D G N ++ YS+ + F+++ ++G ++ + PLD E + V A D
Sbjct: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
Query: 1244 DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSK 1303
G+P LS+S ++TVTVLDVND P F Y + E+ G V V A+DRD+ NS
Sbjct: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSA 788
Query: 1304 LQFEIMPGASFELFEINSDTGEVVTTTI--LDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
+ ++I G + F I++ G + T LD + + F L + D +L +
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVH 845
Query: 1362 CTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
+ D N H P F + Y + V E++ + + ASD D G N + Y +++ N +
Sbjct: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQ- 903
Query: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
F I+ SG ++ LD E +TL I D G P ++ +++V V D ND++P F
Sbjct: 904 FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVA 963
Query: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT--DEASGAFTIDPMSGTLKTSN 1538
+Y V EDA T VL +SA D+D NG+ +Y ++ G FTI+P SG ++T
Sbjct: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
Query: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPT 1598
LDREA S + +A A D + R T V I+V V DVNDN PV F+V + S
Sbjct: 1024 RLDREAVSVYELTAYAVDRGVPPLR-TPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
Query: 1599 NQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYTGE----IQFQQNPSSEYFPIW 1652
+ A D D GPN +++ E +F +D ++GE I EY
Sbjct: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV--- 1139
Query: 1653 LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS--IVTVKAFA 1710
+ ++ T + +R T + ++ ++ L+ V+ + S I + A+
Sbjct: 1140 IVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199
Query: 1711 PDSIQDSMKYSIFSGNEDGVLSLCSKSGQL 1740
PD + D + YS GNE +L + SG+L
Sbjct: 1200 PD-VSDHLFYSFERGNELQLLVVNQTSGEL 1228
Score = 325 bits (834), Expect = 3e-88
Identities = 280/942 (29%), Positives = 428/942 (45%), Gaps = 69/942 (7%)
Query: 1592 LSPESPTNQTTVI-VRADDLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQFQQNPS 1645
L PE+ T V+ V A D D G G +V+S A + +FSID +G I+
Sbjct: 333 LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALD 392
Query: 1646 SEYFPI-WLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTSI 1703
E +L++ D G P + T ++ + + + D F Y+ + EN E G I
Sbjct: 393 RESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPI 452
Query: 1704 VTVKAFAPDSIQDSMKYSIFSGNEDG------VLSLCSKSGQLTVKEPKFLDFEVRNEVQ 1757
+ ++A D+ ++ F G + +SG ++ +D E +
Sbjct: 453 LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR--VDREHMESYE 510
Query: 1758 LIVLAESSGHR-----AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFAT 1812
L+V A G A +V + + DENDN+P F + Y A V E + V++V AT
Sbjct: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
Query: 1813 DLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRL 1872
D D NGL+ Y+I+SGN F ID+L+G I A LD+E Y+L ++A D G P L
Sbjct: 571 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPL 630
Query: 1873 SNTT-VIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSF 1928
SN T + +QV DIND+ P F+ + V + E++ G V H+ D D N+ +S
Sbjct: 631 SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGALVVRVLDV 1985
+ P T F I+ TG V + LD E + Y ++ D ++ V VLDV
Sbjct: 691 TGVA-PDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV 749
Query: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSS--KEFSIDPKNG 2043
NDN P F+ Y + + E VG SV++++A D ++N ISY+I + F+I + G
Sbjct: 750 NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGG 809
Query: 2044 TIFTISPVLLLDTISTTQF--LVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
+ ++ L LD F ++ ASD L V I I D N + P F Y++
Sbjct: 810 -VGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSV 865
Query: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
S++ED +GST+V S D D EN + Y + Q ++ G
Sbjct: 866 SVNEDRPMGSTIVVISASDDD-VGENARITYLLEDNLPQFRIDADS------------GA 912
Query: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
+ L LD E ++ L I A D+G P + T + + V DVNDN P F + Y V E
Sbjct: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
Query: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNE-KGHFYLEENTGVLYLIKPLDYEKMTK 2280
P + + +SA DRD ++ + Y +G + G F +E +G++ ++ LD E ++
Sbjct: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSV 1032
Query: 2281 FTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINAL 2339
+ LT A D V + V V D ND+AP F F V EN + S + I A+
Sbjct: 1033 YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAV 1092
Query: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQA 2399
D D GP + Y IV +LF +D +G++ A LDYE +Y + VQA
Sbjct: 1093 DPDEGPNAHIMYQIVEGNI--------PELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
Query: 2400 KDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD----RQLIGRVEASDADAG 2455
+ V V + ++ P+ Q F N+ +IGR+ A D D
Sbjct: 1145 -TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203
Query: 2456 IDGVILYSLGTSSPFFSVNKTNGNIYLIRAL----PLIKSQL 2493
+ G VN+T+G + L R L PL+ S L
Sbjct: 1204 DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASML 1245
Score = 318 bits (816), Expect = 4e-86
Identities = 279/961 (29%), Positives = 434/961 (45%), Gaps = 76/961 (7%)
Query: 1372 PEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI---IDGNTDECFTINEMS 1427
P+F +Y V EN+ V V+A D DAG + Y + ++ + E F+I+ S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
G + T ALDRE + L + D G P S+ + V V D NDHSP F Y+ ++
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD------EASGAFTIDPMSGTLKTSNTLD 1541
RE+ E G +L L A D D N Y A+ AF IDP SG + TS +D
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
Query: 1542 REARSQHTFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
RE + A D + G RS TV + + V D NDN P + + + + +
Sbjct: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
Query: 1601 TTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQ----FQQNPSSEYFPIWLQ 1654
+ V A D D NG V ++ ++ F+ID TGEIQ EY L+
Sbjct: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYA---LR 619
Query: 1655 LKVTDQG-IPARTTTGLLVIHMEGEDVKIS-FSHHLYKGLVTENCEAGTSIVTVKAFAPD 1712
++ D G P TGL I + + I F ++ V EN G S++ ++A D
Sbjct: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 1713 SIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH---R 1768
+++ ++YS+ D + S +G ++V P LD E V A G
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGP--LDRESVEHYFFGVEARDHGSPPLS 737
Query: 1769 AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828
A V V + D NDN P F Y ++E V+ V A D D+ N I Y I
Sbjct: 738 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITG 795
Query: 1829 GNQEEAFQIDALSGV--ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIN 1886
GN F I GV +T LDY+ + L++ A+D+ L + + + +TD N
Sbjct: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDAN 852
Query: 1887 DNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTG 1945
+ P F + +V + ED G + +S D D+ ++ E N +F ID ++G
Sbjct: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-PQFRIDADSG 911
Query: 1946 VVVLVKTLDFEEMTEYELLIQISDS-------VHYTEGALVVRVLDVNDNPPVFSQDFYQ 1998
+ L LD+E+ Y L I D+ Y E V V DVNDN P F Y
Sbjct: 912 AITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE----VMVNDVNDNAPQFVASHYT 967
Query: 1999 VTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK---EFSIDPKNGTIFTISPVLL 2053
V E P SVL +SATD +++ N + Y + +F+I+P +G + T+ L
Sbjct: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR-LD 1026
Query: 2054 LDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTL 2113
+ +S + A D G P LR +++ ++D+N+ AP F + + + + E+++VGS +
Sbjct: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
Query: 2114 VTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
+ +D D N ++ Y I+ GN F ++ F E L L LD EA
Sbjct: 1087 AQITAVDPD-EGPNAHIMYQIVEGNIPELFQMD--IFSGE--------LTALIDLDYEAR 1135
Query: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP---NFSSL--SYHTHVKESTPLGSH 2228
+ +V+ A+ + PL S A + ++++D NDN P NF L +Y ++ ++ P G
Sbjct: 1136 QEYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI- 1191
Query: 2229 ITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
I + A D D H + Y+ GNE + + +G L L + LD + ++ V +
Sbjct: 1192 IGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVT 1249
Query: 2289 D 2289
D
Sbjct: 1250 D 1250
Score = 274 bits (701), Expect = 8e-73
Identities = 265/959 (27%), Positives = 418/959 (43%), Gaps = 111/959 (11%)
Query: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA----SPQPGVFAID 530
+ HP F + + + + + GTA+ A+D D+G G + YS+A S +F+ID
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 531 RALGVLFLNGSLGAGEQRELTLTLRAEDQGV-HPQAALLVLTVVIEKREHSPSWTFEHLV 589
G++ +L L + A+D G A +V V ++ +HSP FE
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP--VFEQAQ 437
Query: 590 YQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL-----EPSVDSAMFGIRPYTGWIY 644
Y+ + E++ +LQ +A G + LRY + +A F I P +G I
Sbjct: 438 YRETLRENVEEGYPILQLRATD-GDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIS 496
Query: 645 LRRQFDYESTQTYNFRVFAWIP-EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 703
+ D E ++Y V A ++ ++ + V + V DENDN+P F +V E
Sbjct: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
Query: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLS------------------------------ 733
P V+ ++TA D D NG + Y ++S
Sbjct: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
Query: 734 -------DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDE---LQAFVLKSLF 783
D ++ NTG A +I V+ D F T F S E L V+
Sbjct: 617 ALRIRAQDAGRPPLSNNTGLA-SIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 784 CELGEGE-----------------LIN----WVA----LDREHRGHHEMTVLVTDRGSPP 818
+ GE +IN WV+ LDRE H+ V D GSPP
Sbjct: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
Query: 819 RNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEV 878
+A+ +V V+V D+NDNRP F KE H+++ E V V +V A D D N+ +
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTM----KEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAI 789
Query: 879 TYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS--YRMSVIATDQGVPPLQGQAVVNI 936
+Y ++ ++ + F I G T L DY+ +++ + A+D+ L V+I
Sbjct: 790 SYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHI 846
Query: 937 QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996
+ + R + + + E+ + +I +SD + + +D
Sbjct: 847 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASD---DDVGENARITYLLEDNLPQ 903
Query: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQ 1056
F ID+ +G + L LDYE Y + D+ + T ++ + V D ND++P F
Sbjct: 904 FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDNAPQFV 962
Query: 1057 DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
V E+ P T V +A D D + N R+QY ++ G F I P+ G + T
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRD-AHANGRVQYTFQNGEDGDGDFTIEPTSGIVRT 1021
Query: 1117 VSRLDRESIPTVILTVTASDQAVNVTDRRLRS-LTAQIVILDVNDHNPTFISFP-NAHVK 1174
V RLDRE++ LT A D+ V LR+ ++ Q+++ DVND+ P F + VK
Sbjct: 1022 VRRLDREAVSVYELTAYAVDRGV----PPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVK 1077
Query: 1175 EDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQ 1234
E+ VGS+V ITA DPDEG N + Y I+ GN F +D SG LT LDYE + +
Sbjct: 1078 ENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQE 1137
Query: 1235 HILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFK--QHLYEASVKENQN--PGEFVTR 1290
+++ V A + L S T+ V ++D ND +PV Q L+ V + P + R
Sbjct: 1138 YVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGR 1194
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDG 1349
+ A D D V+ L + G +L +N +GE+ + LD V ++ V V DG
Sbjct: 1195 IPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 216 bits (551), Expect = 2e-55
Identities = 253/1008 (25%), Positives = 399/1008 (39%), Gaps = 155/1008 (15%)
Query: 54 PETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 113
PE E G V R V A D D+G G + YSL ++ + + F IDP
Sbjct: 335 PENEAAGTAVLR-------------VVAQDPDAGEAGRLVYSLA-ALMNSRSLELFSIDP 380
Query: 114 HDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDN 173
G I + +DRE Y L V A+D R LSA V V + D ND+
Sbjct: 381 QSGLIRTAAALDRESMERHY-LRVTAQDHGSPR----------LSATTMVAVTVADRNDH 429
Query: 174 HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-----PGNVSSLFTID 228
PVF + Y ++ + + G I+ + ATD D+ + Y + ++ F ID
Sbjct: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
Query: 229 STTGLYSPEVEILSAVNFSADKEVMNSLEMFL--------------PLLRHFKKVERDEE 274
+GL S + D+E M S E+ + + H ++ ++
Sbjct: 490 PRSGLISTSGRV--------DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDN 541
Query: 275 A---AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGE----- 326
A +EK++ A +R R H L+V D Y G
Sbjct: 542 APQFSEKRYVAQ----VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDS 597
Query: 327 --GIIYLTLPLSHLESTTLSLMVSAQDGG--------GLTAVINADVTIHIFQTTLAPAE 376
G I + PL +L + AQD G GL ++ D+ HI
Sbjct: 598 LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-------PI 650
Query: 377 FERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRT 435
F + V E+ P + ++A + + + Y ++ F I+ G +
Sbjct: 651 FVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSV 710
Query: 436 RKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 494
PLD E+ V+A+ GS P +S V +TV+DVNDN P F +R+++
Sbjct: 711 SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAA 770
Query: 495 PGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDR--ALGVLFLNGSLGAGEQRELT 551
GT++ A DRD+ N I Y I FAI +G++ L L ++R
Sbjct: 771 VGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFK 828
Query: 552 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 611
L L A D+ +H V + + H P F+ Y V V+E PM + +
Sbjct: 829 LVLTASDRALHDHC--YVHINITDANTHRP--VFQSAHYSVSVNED-RPMGSTIVVISAS 883
Query: 612 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 671
+ + Y LE ++ F I +G I L+ DYE TY + A ++G
Sbjct: 884 DDDVGENARITYLLEDNL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITA--RDNGIP 939
Query: 672 QNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 730
Q TT + V V D NDN+P F+ V E P + +I+A D D+ NG++ Y
Sbjct: 940 QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999
Query: 731 LLS----DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ DG F + P +G T+
Sbjct: 1000 FQNGEDGDGD-FTIEPTSGIVRTVR----------------------------------- 1023
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
LDRE +E+T DRG PP +++ V V D+NDN P F P +
Sbjct: 1024 ---------RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF----PAE 1070
Query: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
E V+V E V +V + A DPDEG NA + Y + + + F++D +GE+ L
Sbjct: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQ-NIRHLIIPENLKPTK 965
Y+ R Y + V AT PL +A V+++++ + +++ I N T
Sbjct: 1131 DYEARQEYVIVVQATS---APLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTF 1187
Query: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
+I + L +S ++ ++ ++G+L LS++LD
Sbjct: 1188 PSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
Score = 212 bits (540), Expect = 4e-54
Identities = 189/665 (28%), Positives = 307/665 (46%), Gaps = 48/665 (7%)
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSA--FIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDF 1955
+ E+ G V V D D A ++S A N + F+ID +G++ LD
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 1956 EEMTEYELLIQISD--SVHYTEGALV-VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVL 2012
E M + L + D S + +V V V D ND+ PVF Q Y+ T+ E++ GY +L
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
Query: 2013 TLSATDLES--NENISYRIL-------SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFL 2063
L ATD ++ N N+ YR + +++ F IDP++G I T V + + + + +
Sbjct: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDR-EHMESYELV 512
Query: 2064 VEASDGGN-PDLRALTL-VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDH 2121
VEASD G P R+ T+ V I + D N+ AP+F+ K Y + ED + ++ + D
Sbjct: 513 VEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDR 572
Query: 2122 DWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVIL 2181
D N V Y+IISGNS+ +F +++ G + ++ LD EA + L I
Sbjct: 573 D-KDANGLVHYNIISGNSRGHFAIDSL----------TGEIQVVAPLDFEAEREYALRIR 621
Query: 2182 ASDSGCPPLSS-TAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTG 2240
A D+G PPLS+ T + SIQV+D+ND+ P F S + V E+ PLG + + A D D G
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 2241 SHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSF-AV 2299
+A + Y++ F + TG + + PLD E + + V+A D S A
Sbjct: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASAS 741
Query: 2300 VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFL 2359
V V+VLD ND+ P+F + + E+ + +++ S+ A+D DA ++Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQI------ 793
Query: 2360 THGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGID 2419
T G + + G + LDY+ + L + A D+ V ++I +
Sbjct: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDAN 852
Query: 2420 EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN 2479
P+F Y ++ E I + ASD D G + I Y L + P F ++ +G
Sbjct: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGA 912
Query: 2480 IYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSF 2539
I L ++ L+ ED + + + + + T +V V + F +S
Sbjct: 913 ITL-------QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 2540 SISLV 2544
LV
Sbjct: 966 YTGLV 970
Score = 186 bits (473), Expect = 2e-46
Identities = 243/1035 (23%), Positives = 405/1035 (39%), Gaps = 144/1035 (13%)
Query: 172 DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTID 228
+ HP F Y T + + GT ++ V+A D D+G G + Y L+ LF+ID
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 229 STTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEAS----- 283
+GL + D+E M RH+ +V + + + +
Sbjct: 380 PQSGLIRTAAAL--------DRESME---------RHYLRVTAQDHGSPRLSATTMVAVT 422
Query: 284 -------RGWFMRFKGRRHLH----------YLKVQDEAASADGEAAARYVANLAKILGE 326
F + + R L L+ D A + R+V A
Sbjct: 423 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 482
Query: 327 GIIYLTLPLSHLEST----------TLSLMVSAQDGGGLTAVINADVTIHIF---QTTLA 373
+ P S L ST + L+V A D G +A V +HI + A
Sbjct: 483 AAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA 542
Query: 374 PAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGT 432
P +F +Y V EDV + + V A + +++ + Y I SG+ G F+I G
Sbjct: 543 P-QFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE 601
Query: 433 IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRIS 490
I+ PLD E + L ++AQ P S+ +I V+D+ND+ P F+ T ++ +
Sbjct: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
Query: 491 QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRE 549
+ P G ++ +A D D G N + YS+ P F I+ A G + ++G L
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 550 LTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 608
+ A D G P +A +TV V++ ++ P +T + Y + ++E + T ++
Sbjct: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE--YHLRLNEDAAVGTSVVSVT 779
Query: 609 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPY--TGWIYLRRQFDYESTQTYNFRVFAWIP 666
A + A S + Y + F I G + L DY+ + + + A
Sbjct: 780 A---VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA--- 833
Query: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D L + V + + D N + P F + V E I I+A D D G+N +
Sbjct: 834 SDRALHD-HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENAR 892
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ Y L + F+++ ++G IT LQA
Sbjct: 893 ITYLLEDNLPQFRIDADSG------AIT-------------------LQA---------- 917
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
LD E + + + + D G P + T V V V D+NDN P F
Sbjct: 918 ---------PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF----VAS 964
Query: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV-SSEDSSDHFKIDANNGEIRTTTI 905
V E P V + A D D N V Y+ + ED F I+ +G +RT
Sbjct: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
Query: 906 LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
L + Y ++ A D+GVPPL+ + + V ++ + + + EN
Sbjct: 1025 LDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGS 1084
Query: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
+++ I + D + N + + IV + F++D +G+L +LDYE Y+ V
Sbjct: 1085 VVAQITAVDP-DEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
Query: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI-----VISVEENVPIGTLVYVFNAK 1080
T + L S + + + DQND+SP + I V + + P G ++ A
Sbjct: 1144 AT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAY 1198
Query: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
D D ++ + Y E N +++ + G L +LD + VT +D
Sbjct: 1199 DPD---VSDHLFYSFERGNE-LQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD---- 1250
Query: 1141 VTDRRLRSLTAQIVI 1155
L S+TAQ V+
Sbjct: 1251 ----GLHSVTAQCVL 1261
Score = 127 bits (320), Expect = 1e-28
Identities = 106/405 (26%), Positives = 181/405 (44%), Gaps = 33/405 (8%)
Query: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTREN--TYVEYSIISGNSQNNFHVE 2146
N P+F +Y + E+ G+ ++ D D Y ++++ S F ++
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206
Q G + +LDRE+ H L + A D G P LS+T ++++ V D ND+
Sbjct: 380 P----------QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDH 429
Query: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS-----GNEKGHFYLE 2261
P F Y ++E+ G I + A D D +A + Y + F ++
Sbjct: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
Query: 2262 ENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK---HFSFAVVFVSVLDDNDHAPQFMFSS 2318
+G++ +D E M + L V+ASD ++ + V ++VLD+ND+APQF
Sbjct: 490 PRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKR 549
Query: 2319 FSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGD 2378
+ V E++ + + + A D D G + Y+I+S G S H F ID LTG+
Sbjct: 550 YVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIIS------GNSRGH--FAIDSLTGE 601
Query: 2379 IHAKQILDYENGNKYCLTVQAKDKGDATASL---VVWVDIEGIDEFEPIFTQDQYFFTLP 2435
I LD+E +Y L ++A+D G S + + + I++ PIF + ++
Sbjct: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
Query: 2436 EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPF--FSVNKTNG 2478
E + ++A DAD G + + YSL +P F +N G
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATG 706
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 360 bits (923), Expect = 1e-98
Identities = 298/973 (30%), Positives = 455/973 (46%), Gaps = 78/973 (8%)
Query: 1475 SPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF---LTDEAS-GAFTIDPM 1530
S FP YQ ++ E+ GT++L L A EG + Y+ L DE S G F ID
Sbjct: 242 SLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+G + T + LDRE + H A D S RS T I V V D ND+ PV EQ+ +
Sbjct: 302 TGAVSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRE 360
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEIQ----FQQNPS 1645
+ + +RA D D N + + +F +++ +G + + +
Sbjct: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420
Query: 1646 SEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTS 1702
+EY L ++ DQG + +++E ED + FS Y V E+ T+
Sbjct: 421 AEY---QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA 477
Query: 1703 IVTVKAFAPDSIQD-SMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVL 1761
++ V+A D Q+ ++ YSI SGN G L S SG L V P LDFE + L +
Sbjct: 478 VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIK 535
Query: 1762 AESSGHRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSG 1817
A+ G V+V + D NDN P F S +QA+V E+ V+ + A D DSG
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 1818 LNGLIEYSIL-----------SGNQEEA------FQIDALSGVITTKAILDYELTSSYSL 1860
N + Y ++ +G + A FQI SG IT A LD E YS
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
Query: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVD 1919
V+A D G P +S++T + + V D+NDN P F P+ + + ED+ G V + D D
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 1920 LNSAFIFSFAKESNPGTKFAI--DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA 1977
NS + N +FA+ + G++ L LD+++ +Y L + SD
Sbjct: 716 ANSVITYQLT-GGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAH 774
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE 2035
+++ V D N + PVF Y V+V E PVG S+ TLSA D ++ EN I+Y I +
Sbjct: 775 VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
Query: 2036 FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT 2095
F IDP +GT++T+ + + ++ T + A D G P T +EI I D N+ AP+F
Sbjct: 835 FRIDPDSGTMYTMMELDYENQVAYT-LTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 2096 VKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEY 2154
Y S+ EDA ++++ S D D + N + Y+ G + +F++E
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDDGDGDFYIE-------- 944
Query: 2155 PYKQVGYLVLLHSLDREASASHELVILASDSGCP-PLSSTAVISIQVLDVNDNPPNFSSL 2213
G + LDRE A + L LA D G P PLS++ I + +LD+NDN P F
Sbjct: 945 --PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKD 1002
Query: 2214 SYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPL 2273
V+E+ P+GS + + AND D G +A+I+Y I+ G+ + F L+ G L + L
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVEL 1062
Query: 2274 DYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLP 2328
D+E ++ L VQA+ A S A V + ++D ND+ P Q +F+++ + P
Sbjct: 1063 DFEVRREYVLVVQATSAPL--VSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
Query: 2329 ISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYE 2388
+ I I A D D L Y+ V + L L+DP TG++ + LD
Sbjct: 1121 -TGVIGCIPAHDPDVS--DSLNYTFV--------QGNELRLLLLDPATGELQLSRDLDNN 1169
Query: 2389 NGNKYCLTVQAKD 2401
+ + V D
Sbjct: 1170 RPLEALMEVSVSD 1182
Score = 356 bits (914), Expect = 2e-97
Identities = 268/853 (31%), Positives = 426/853 (49%), Gaps = 72/853 (8%)
Query: 1689 YKGLVTENCEAGTSIVTVKA-FAPDSIQDSMKY---SIFSGNEDGVLSLCSKSGQLTVKE 1744
Y+ + EN AGT I+ + A + + ++ + Y +F G + S +G V
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG--AVST 307
Query: 1745 PKFLDFEVRNEVQLIVLA---ESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801
LD E + L V A + A + VL++D ND+SP FEQS Y+ V E+
Sbjct: 308 DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
Query: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861
V+ + A+D DS +N + Y +L G + FQ++ SGV++T+A+LD E + Y L+
Sbjct: 368 VGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLL 426
Query: 1862 VQATDKGMPR--LSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDV 1918
V+A D+G LS T + ++V D NDN P F V++ ED V V D
Sbjct: 427 VEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDR 486
Query: 1919 DL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS----VH 1972
D N+A +S N +F + +G++ ++ LDFE++ +Y L I+ D +
Sbjct: 487 DQGQNAAIHYSILS-GNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLI 545
Query: 1973 YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ G + V+VLDVNDN P+F +Q TV E++P+GY V+ + A D +S EN + YR++
Sbjct: 546 NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
Query: 2031 SSSKEF----SIDPKNGTI--------------FTISPVLLLDTISTTQFLVEASDGGNP 2072
++ F S PKN T+ L + + F VEA D G+P
Sbjct: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
Query: 2073 DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + T V I + D+N+ P FT +Y L L+EDA VGS+++T D D N+ + Y
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD---ANSVITY 722
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSS 2192
+ GN++N F + ++ + G + L LD + + L + ASD S
Sbjct: 723 QLTGGNTRNRFALSSQ--------RGGGLITLALPLDYKQEQQYVLAVTASDG---TRSH 771
Query: 2193 TAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISG 2252
TA + I V D N + P F S Y V E P+G+ I +SAND DTG +A I Y I
Sbjct: 772 TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI--Q 829
Query: 2253 NEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF-VSVLDDNDHA 2311
+ F ++ ++G +Y + LDYE +TLT+ A D S + +LD ND+A
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 2312 PQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFL 2371
PQF++ + + E+ P S++I ++A D D+GP G L Y+ G D D F
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG------GDDGDGD-FY 942
Query: 2372 IDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT---ASLVVWVDIEGIDEFEPIFTQD 2428
I+P +G I ++ LD EN Y L A D+G T AS+ + V I I++ P+F +D
Sbjct: 943 IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKD 1002
Query: 2429 QYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL 2486
+ + E N ++ ++ A+D D G + I+Y + G FF ++ NG+ +RA+
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD---LRAM 1059
Query: 2487 PLIKSQLNKEDTL 2499
+ ++ +E L
Sbjct: 1060 VELDFEVRREYVL 1072
Score = 354 bits (909), Expect = 6e-97
Identities = 299/1004 (29%), Positives = 469/1004 (46%), Gaps = 84/1004 (8%)
Query: 1169 PNAHVK--EDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNENMTFMLDESSGLLTT 1223
PN V E+ G+L+ + AH EG +V+Y + F +D ++G ++T
Sbjct: 248 PNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST 307
Query: 1224 TCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQN 1283
LD E K H+L V A+D TP S++ +TV V D ND +PVF+Q Y V+EN
Sbjct: 308 DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
Query: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343
G V + A DRDS +N+ L++ ++ GA +++F++N +G V T +LDRE + L
Sbjct: 368 VGYEVLTIRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDREEAAEYQLL 426
Query: 1344 VLVRDGGF--PSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDM 1400
V D G LS+T T+ VEDEND+ P+F +Y ++V E+ V V A+D
Sbjct: 427 VEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDR 486
Query: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--R 1458
D G N A+ Y I+ GN F ++ +SG L LD E + ++L I D G PP
Sbjct: 487 DQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLIN 546
Query: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518
SS + + V+VLD ND+ P F + +Q++V E+ +G V+ + AVD D G N + Y L
Sbjct: 547 SSGV-VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
Query: 1519 DEASG------------------AFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ 1560
D AS F I SG + LDRE ++F A D
Sbjct: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD---H 662
Query: 1561 GS--RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTV 1618
GS S++ + + V DVNDNDPV Q +++ L+ ++ + + ++A D D T
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 1619 VFSFAETQSMFSIDKYTG------EIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLV 1672
+ T++ F++ G + +Y L VT T +L+
Sbjct: 723 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYV-----LAVTASDGTRSHTAHVLI 777
Query: 1673 IHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVL 1731
+ + F Y V+E+ GTSI T+ A D+ +++ + Y I +D V
Sbjct: 778 NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI----QDPVP 833
Query: 1732 SLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFE 1788
T+ LD+E + L ++A+ +G + +LI D NDN+P F
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEA-FQIDALSGVITTK 1847
YQ S+ E + ++QV ATD DSG NG + Y+ G+ + F I+ SGVI T+
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
Query: 1848 AILDYELTSSYSLIVQATDKGMPR-LSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP 1906
LD E + Y+L A D+G P LS + I+V + DINDNAP F E E++ P
Sbjct: 954 RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
Query: 1907 -GVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELL 1964
G +V + +D D +A I E + F +D G + + LDFE EY L+
Sbjct: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
Query: 1965 IQISDSVHYTEGALVVRVLDVNDNPPVFSQDF------YQVTVPESIPVGYSVLTLSATD 2018
+Q + + + + + ++D NDNPPV DF Y S P G + + A D
Sbjct: 1074 VQATSAPLVSRATVHILLVDQNDNPPVL-PDFQILFNNYVTNKSNSFPTGV-IGCIPAHD 1131
Query: 2019 LESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078
+ +++++Y + ++ +LLLD + L D P L A
Sbjct: 1132 PDVSDSLNYTFVQGNE--------------LRLLLLDPATGELQLSRDLDNNRP-LEA-- 1174
Query: 2079 LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHD 2122
L+E+ + D + F + +++D L S V N+ +
Sbjct: 1175 LMEVSVSDGIHSVTAFCTLRVTI-ITDDMLTNSITVRLENMSQE 1217
Score = 333 bits (854), Expect = 1e-90
Identities = 280/905 (30%), Positives = 412/905 (45%), Gaps = 73/905 (8%)
Query: 1625 TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPART-TTGLLVIHMEGEDVKI 1682
++ F ID TG + E L++K D P R+ TT + V+ + D
Sbjct: 292 SRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP 351
Query: 1683 SFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLT 1741
F Y+ V EN E G ++T++A DS I +++Y + G D V L SG ++
Sbjct: 352 VFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVS 410
Query: 1742 VKEPKFLDFEVRNEVQLIVLAESSGHR-----AYCKVAVLIQDENDNSPCFEQSIYQASV 1796
+ LD E E QL+V A G A V + ++DENDN P F + Y V
Sbjct: 411 TRA--VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
Query: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
E N V++V ATD D G N I YSILSGN F + +LSG++ LD+E
Sbjct: 469 PEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQ 528
Query: 1857 SYSLIVQATDKGMPRLSNTT-VIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVS 1914
YSL ++A D G P L N++ V+ VQV D+NDN P F+ S +++P G V H+
Sbjct: 529 KYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ 588
Query: 1915 VHDVD-----------LNSAFIF---SFAKESNPGTK----FAIDQNTGVVVLVKTLDFE 1956
D D +++A F A NP F I ++G + + LD E
Sbjct: 589 AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648
Query: 1957 EMTEYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013
E+ Y ++ D + ++ + VLDVNDN PVF+Q Y++ + E VG SVLT
Sbjct: 649 EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
Query: 2014 LSATDLESNENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQFL--VEASDG 2069
L A D ++N I+Y++ + F++ + G I+ L LD Q++ V ASDG
Sbjct: 709 LQARDRDANSVITYQLTGGNTRNRFALSSQRGGGL-ITLALPLDYKQEQQYVLAVTASDG 767
Query: 2070 GNPDLRALTL-VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128
R+ T V I + D N + P F Y +S+SED VG+++ T S D D T EN
Sbjct: 768 ----TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDED-TGENA 822
Query: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188
+ Y I Q ++ G + + LD E ++ L I+A D+G P
Sbjct: 823 RITYVIQDPVPQFRIDPDS------------GTMYTMMELDYENQVAYTLTIMAQDNGIP 870
Query: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
S T + I +LD NDN P F Y + E P + I VSA DRD+G + ++Y
Sbjct: 871 QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT 930
Query: 2249 IISGNE-KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAV-VFVSVL 2305
G++ G FY+E +GV+ + LD E + + L A D S +V + V++L
Sbjct: 931 FQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL 990
Query: 2306 DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY 2365
D ND+AP F V EN P+ S + I A D D GP ++ Y IV
Sbjct: 991 DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM------- 1043
Query: 2366 DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIF 2425
F +D L GD+ A LD+E +Y L VQA + V + + ++ P+
Sbjct: 1044 -RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-TSAPLVSRATVHILLVDQNDNPPVL 1101
Query: 2426 TQDQYFFTLPEKNKDRQ----LIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIY 2481
Q F NK +IG + A D D + G ++ G +
Sbjct: 1102 PDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQ 1161
Query: 2482 LIRAL 2486
L R L
Sbjct: 1162 LSRDL 1166
Score = 302 bits (774), Expect = 3e-81
Identities = 278/1003 (27%), Positives = 436/1003 (43%), Gaps = 63/1003 (6%)
Query: 376 EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLG----GKFSIHPRLG 431
+F P Y ++E+ P + I + A + E G G F I G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 432 TIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 490
+ T LD ET+ VL V+A + P ++T + + V D ND+ P F ++ R+
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 491 QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL 550
+ G + RA DRDS N +RY + VF ++ + GV+ L E E
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
Query: 551 TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQA 609
L + A DQG +P TV IE + + ++ F Y V+V E + T +L+ QA
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
Query: 610 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 669
+ A+ + YS+ + F + +G + + D+E Q Y+ + A
Sbjct: 484 TDRDQGQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
Query: 670 FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLL 728
L N S V V+V D NDN P F+ V E+ VP G + I A+D DSG+N +L
Sbjct: 543 PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLEN-VPLGYPVVHIQAVDADSGENARLH 601
Query: 729 YFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGE 788
Y L+ F + GP DF F
Sbjct: 602 YRLVDTASTFLGGGSAGPKNPA------------PTPDFPFQIHN-------------SS 636
Query: 789 GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 848
G + LDRE H+ V D GSPP +++ +V ++V D+NDN P F Q P EL
Sbjct: 637 GWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ--PTYEL 694
Query: 849 HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSY 908
+ E V V T+ A+D D N+ +TY ++ ++ + F + + G T L
Sbjct: 695 RLN--EDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
Query: 909 DYR--PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
DY+ Y ++V A+D A V I V + R + + + + E+
Sbjct: 751 DYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVIT 1026
++ + ++D + + V D F ID +G ++ ELDYE Y ++
Sbjct: 808 IATLSAND---EDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 1027 TDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSF 1086
D+ S T L I + D ND++P F + S+ E+ P T + +A D D S
Sbjct: 865 QDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD-SG 922
Query: 1087 LNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL 1146
N R+ Y + + G F I P+ G + T RLDRE++ L A D+
Sbjct: 923 PNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP--LS 980
Query: 1147 RSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILS 1205
S+ Q+ ILD+ND+ P F V+E+ VGS+V I A+DPDEG N ++ Y I+
Sbjct: 981 ASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
Query: 1206 GNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
G+ F LD +G L LD+E++ +++L V A + L S T+ + ++D ND
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDN 1097
Query: 1266 APVFK--QHLYEASV--KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINS 1321
PV Q L+ V K N P + + A D D V+ L + + G L ++
Sbjct: 1098 PPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDP 1155
Query: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTV 1364
TGE+ + LD + V V D G S+++ T+ T+
Sbjct: 1156 ATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVTI 1197
Score = 290 bits (741), Expect = 2e-77
Identities = 269/984 (27%), Positives = 428/984 (43%), Gaps = 74/984 (7%)
Query: 1373 EFIVSSYDIEVLENQEPEVVYTVLASDMDA-GNNRAVEYH---IIDGNTDECFTINEMSG 1428
+F + +Y + + EN+ + L + G V Y+ + D + F I+ +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR 1488
+ST LDRE L + D PPRS+ ++ V V D NDHSP F Y+ VR
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 1489 EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548
E+ EVG VL + A D+D +N Y + A F ++ SG + T LDRE +++
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
Query: 1549 TFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRA 1607
A D G S T + + V D NDN P + + V + + N + V+A
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
Query: 1608 DDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPA 1664
D D G N + +S F + +G + E + L +K D G P
Sbjct: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPP 543
Query: 1665 R-TTTGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKY-- 1720
++G++ + ++ D + F ++ V EN G +V ++A DS +++ +
Sbjct: 544 LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYR 603
Query: 1721 -----SIFSG-----------NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES 1764
S F G D + + SG +TV LD E V A
Sbjct: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE--LDREEVEHYSFGVEAVD 661
Query: 1765 SGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGL 1821
G + V++ + D NDN P F Q Y+ ++E + V+ + A D D+ N +
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSV 719
Query: 1822 IEYSILSGNQEEAFQIDAL--SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIK 1879
I Y + GN F + + G+IT LDY+ Y L V A+D S+T +
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD---GTRSHTAHVL 776
Query: 1880 VQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF 1938
+ VTD N + P F S V ++ED G + +S +D D ++ + +P +F
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-DPVPQF 835
Query: 1939 AIDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQD 1995
ID ++G + + LD+E Y L I D+ L + +LD NDN P F D
Sbjct: 836 RIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWD 895
Query: 1996 FYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK---EFSIDPKNGTIFTISP 2050
FYQ ++ E P S+L +SATD +S N + Y +F I+P +G I T
Sbjct: 896 FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT-QR 954
Query: 2051 VLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
L + ++ A D G+P L A +++ I D+N+ AP F L + E+ V
Sbjct: 955 RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPV 1014
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
GS + D D N + Y I+ G+ ++ F ++ G L + LD
Sbjct: 1015 GSVVAKIRANDPD-EGPNAQIMYQIVEGDMRHFFQLDL----------LNGDLRAMVELD 1063
Query: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP---PNFSSL--SYHTHVKESTP 2224
E + LV+ A+ + PL S A + I ++D NDNP P+F L +Y T+ S P
Sbjct: 1064 FEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
Query: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLT 2284
G I + A+D D + Y + GNE L+ TG L L + LD + + +
Sbjct: 1121 TGV-IGCIPAHDPDVSD--SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
Query: 2285 VQASDAEKKHFSFAVVFVSVLDDN 2308
V SD +F + V+++ D+
Sbjct: 1178 VSVSDGIHSVTAFCTLRVTIITDD 1201
Score = 244 bits (624), Expect = 7e-64
Identities = 265/1051 (25%), Positives = 443/1051 (42%), Gaps = 151/1051 (14%)
Query: 98 DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGL 157
+G + FRID G + +DRE T+ L V+A D
Sbjct: 285 EGLFDERSRGYFRIDSATGAVSTDSVLDRETKE-THVLRVKAVDYSTPPR---------- 333
Query: 158 SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 217
SA ++ V ++D ND+ PVF S Y + + + G E++ + A+D+DS I + Y ++
Sbjct: 334 SATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVL 393
Query: 218 PGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKK--------- 268
G +F ++ ++G+ S + D+E ++ + +
Sbjct: 394 -GGAWDVFQLNESSGVVSTRAVL--------DREEAAEYQLLVEANDQGRNPGPLSATAT 444
Query: 269 --VERDEEAAEKKFEASRGWFMRFKGRRHLH--YLKVQDEAASADGEAAARYVANLAKIL 324
+E ++E + + + ++ L+ L+VQ AA Y +
Sbjct: 445 VYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVA 504
Query: 325 GE-------GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD--VTIHIFQTTLAPA 375
G+ GI+ + PL + SL + AQDGG +IN+ V++ +
Sbjct: 505 GQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR-PPLINSSGVVSVQVLDVNDNEP 563
Query: 376 EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRI---SSGDLGG--------- 422
F + V E+VP P+ ++A + + + YR+ +S LGG
Sbjct: 564 IFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPA 623
Query: 423 -----KFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 476
F IH G I LD E V+A GS P SST V+ITV+DVNDN
Sbjct: 624 PTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDN 683
Query: 477 HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAID--RAL 533
P F + + E+R+++ G+++ +A DRD+ N +I Y + FA+ R
Sbjct: 684 DPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGG 741
Query: 534 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVE 593
G++ L L ++++ L + A D G A +++ V + H P + H Y V
Sbjct: 742 GLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVT-DANTHRPVFQSSH--YTVS 797
Query: 594 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 653
VSE T + A+ A + Y ++ V F I P +G +Y + DYE+
Sbjct: 798 VSEDRPVGTSIATLSANDEDTGENAR-ITYVIQDPVPQ--FRIDPDSGTMYTMMELDYEN 854
Query: 654 TQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 712
Y + A ++G Q TT + + + D NDN+P FL D + E P I
Sbjct: 855 QVAYTLTIMA--QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSIL 912
Query: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
+++A D DSG NG+LLY F G D
Sbjct: 913 QVSATDRDSGPNGRLLY-------------------------------TFQGGDDGDGD- 940
Query: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTD 831
+ E G + LDRE+ + + L DRGSP P +A++ + V++ D
Sbjct: 941 ---------FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD 991
Query: 832 INDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHF 891
INDN P F + EL + V E PV +V + A DPDEG NA++ Y + D F
Sbjct: 992 INDNAPMFEK----DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047
Query: 892 KIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI------PLSKGR 945
++D NG++R L ++ R Y + V AT PL +A V+I ++ P+
Sbjct: 1048 QLDLLNGDLRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDF 1104
Query: 946 AIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005
I+ N ++ N PT ++ I + D + L+++ V ++ +D +TG+
Sbjct: 1105 QILFNN--YVTNKSNSFPTGVIGCIPAHD---PDVSDSLNYTFVQGNELRLLLLDPATGE 1159
Query: 1006 LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVED----------QNDHSPSF 1055
L LS++LD L V +D +++ T+ ++I +D +N F
Sbjct: 1160 LQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKF 1219
Query: 1056 QDELIVISVEENVPIGTL----VYVFNAKDD 1082
L+ + VE + + V+VFN ++D
Sbjct: 1220 LSPLLALFVEGVAAVLSTTKDDVFVFNVQND 1250
Score = 205 bits (521), Expect = 6e-52
Identities = 225/902 (24%), Positives = 370/902 (41%), Gaps = 119/902 (13%)
Query: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
+ ASD DS + + Y + G A F+++ G + +DRE + A Y LLVE
Sbjct: 375 IRASDRDSPINANLRYRVLGG-----AWDVFQLNESSGVVSTRAVLDRE-EAAEYQLLVE 428
Query: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198
A D G LSA A V +++ED NDN+P F+ YV + ++ T ++
Sbjct: 429 ANDQGRN--------PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
Query: 199 VLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEM 258
V ATD+D G + Y ++ GNV+ F + S +G+ +++++ ++F ++ S++
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGI----LDVINPLDFEDVQKYSLSIKA 536
Query: 259 F----LPLLRHFKKVE---RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD-G 310
PL+ V D E F +S + L Y V +A AD G
Sbjct: 537 QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSP-FQATVLENVPLGYPVVHIQAVDADSG 595
Query: 311 EAAA---RYVANLAKILG----------------------EGIIYLTLPLSHLESTTLSL 345
E A R V + LG G I + L E S
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
Query: 346 MVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPL 405
V A D G + V+I + F +P Y + ED S + T++AR+
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARD-R 714
Query: 406 NSSEPIFYRISSGDLGGKFSIHPRL--GTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS 463
+++ I Y+++ G+ +F++ + G I PLD++ + VL V A G+ +
Sbjct: 715 DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAH 774
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ 523
+N+T D N + P F + + +S+ P GT++ A D D+G N I Y I P
Sbjct: 775 VLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV 832
Query: 524 PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPS 582
P F ID G ++ L Q TLT+ A+D G+ ++ L + +++ +++P
Sbjct: 833 P-QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
Query: 583 WTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVD-SAMFGIRPY 639
+ ++ YQ + E P T +LQ A GP L Y+ + D F I P
Sbjct: 892 FLWD--FYQGSIFEDAPPSTSILQVSATDRDSGPN---GRLLYTFQGGDDGDGDFYIEPT 946
Query: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFL 699
+G I +R+ D E+ YN A + S + V + D NDN+P F D L L
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 700 KVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGPAGTIYVITWAD 757
VEE+ V+ KI A D D G N Q++Y ++ FF++
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQL----------------- 1049
Query: 758 GAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSP 817
+L G+L V LD E R + VLV S
Sbjct: 1050 ---------------------------DLLNGDLRAMVELDFEVRREY---VLVVQATSA 1079
Query: 818 PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAE 877
P + V++ + D NDN P P +V ++ + A DPD ++
Sbjct: 1080 PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
Query: 878 VTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQ 937
T+ +E +D GE++ + L + RP + ++ G+ + + +
Sbjct: 1140 YTFVQGNE--LRLLLLDPATGELQLSRDLD-NNRPLEALMEVSVSDGIHSVTAFCTLRVT 1196
Query: 938 VI 939
+I
Sbjct: 1197 II 1198
Score = 202 bits (515), Expect = 3e-51
Identities = 176/571 (30%), Positives = 272/571 (47%), Gaps = 47/571 (8%)
Query: 1992 FSQDFYQVTVPESIPVGYSVLTLSA--TDLESNENISYRILSSSKE-----FSIDPKNGT 2044
F YQV + E+ P G +L L A T E +SY + E F ID G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 2045 IFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLS 2104
+ T S VL +T T V+A D P A T + + ++D N+++P F Y +
Sbjct: 305 VSTDS-VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 2105 EDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVL 2164
E+ VG ++T D D + N + Y ++ G + + F + + G +
Sbjct: 364 ENLEVGYEVLTIRASDRD-SPINANLRYRVLGG-AWDVFQLN----------ESSGVVST 411
Query: 2165 LHSLDREASASHELVILASDSGCPP--LSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222
LDRE +A ++L++ A+D G P LS+TA + I+V D NDN P FS +Y V E
Sbjct: 412 RAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
Query: 2223 TPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282
L + + V A DRD G +A I Y+I+SGN G FYL +G+L +I PLD+E + K++
Sbjct: 472 VGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS 531
Query: 2283 LTVQASDAEKKHF--SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD 2340
L+++A D + S VV V VLD ND+ P F+ S F V EN+P+ + I A+D
Sbjct: 532 LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
Query: 2341 FDAGPYGELTYSIV--SPCFLTHGMSYDHD-------LFLIDPLTGDIHAKQILDYENGN 2391
D+G L Y +V + FL G + + F I +G I LD E
Sbjct: 592 ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
Query: 2392 KYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEA 2449
Y V+A D G ++S V + + +++ +P+FTQ Y L E + ++A
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
Query: 2450 SDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHS 2507
D DA + VI Y L G + F+++ G + ALPL Q + ++A +
Sbjct: 712 RDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQ------EQQYVLAVT 763
Query: 2508 PKSDSKFASCTVFVNVSFSSEGTPLAVFASS 2538
++ + V +NV+ ++ P VF SS
Sbjct: 764 ASDGTRSHTAHVLINVTDANTHRP--VFQSS 792
Score = 61.6 bits (148), Expect = 1e-08
Identities = 44/163 (26%), Positives = 73/163 (44%), Gaps = 13/163 (7%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
+V+A+D DSG G + Y+ G + F I+P G I + +DRE + A Y+L
Sbjct: 913 QVSATDRDSGPNGRLLYTFQGGD---DGDGDFYIEPTSGVIRTQRRLDRE-NVAVYNLWA 968
Query: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
A D LSA ++V + D+NDN P+F + + G+ +
Sbjct: 969 LAVDRGSPTP---------LSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVA 1019
Query: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
+ A D D G + Y+++ G++ F +D G VE+
Sbjct: 1020 KIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVEL 1062
Score = 37.4 bits (85), Expect = 0.22
Identities = 42/171 (24%), Positives = 71/171 (41%), Gaps = 26/171 (15%)
Query: 67 QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126
+E N ++ A+D D G I Y + +G + + F++D +G + ++D
Sbjct: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH----FFQLDLLNGDLRAMVELDF 1064
Query: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNP-----ST 181
E Y L+V+A L ++A V + L D NDN PV +
Sbjct: 1065 EVR-REYVLVVQATSAP-------------LVSRATVHILLVDQNDNPPVLPDFQILFNN 1110
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232
YVT+ S+ G +I + D + ++ Y + GN L +D TG
Sbjct: 1111 YVTNKSNSFPTG--VIGCIPA-HDPDVSDSLNYTFVQGNELRLLLLDPATG 1158
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 282 bits (722), Expect = 3e-75
Identities = 340/1260 (26%), Positives = 544/1260 (43%), Gaps = 156/1260 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVSSEDSSDHFKIDANNGEIRTTTIL-----SYDYRPSYRMSVIATD-QGVPPLQGQAV 933
Y + + N TTT+ D P + V+ + + PL QA
Sbjct: 189 YVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 248
Query: 934 VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVA--D 991
+ P I++ I+ + N++P SD G L+ +V +
Sbjct: 249 IPELRTPEELNPIIVTPPIQAIDQDRNIQP--------PSDR-----PGILYSILVGTPE 295
Query: 992 DKDGHFEIDSSTGDLFLSKELDYETTSHYLF-RVITTDHSKNLSLSSTVFLSIDVEDQND 1050
D F + T +L L + ++ + H F VI + L + L I++ D+N+
Sbjct: 296 DYPRFFHMHPRTAELSLLEPVNRD--FHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
Query: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYI-----------ESH- 1098
SP F + E+ P+G + D L S ++ E H
Sbjct: 354 QSPYFTMPSYQGYILESAPVGATI-------SDSLNLTSPLRIVALDKDIEDTKDPELHL 406
Query: 1099 --NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
N T+ F + + T L + +DRE T ++TA D + + I
Sbjct: 407 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPVIVNIQ 461
Query: 1155 ILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
++D ND+ PTF IS+ + +V D+ G V +TA D DEG NG++TY IL G + F
Sbjct: 462 VMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DF 519
Query: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA--LSSSQTLTVTVLDVNDEAPV-F 1269
++++++GL+T ++ + + LTV A D+ PA +S T+ + VL N+++P F
Sbjct: 520 IINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRF 579
Query: 1270 KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTT 1329
Q +Y + E G + ++A DR+ + + I G +F ++ TG +
Sbjct: 580 PQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLG 636
Query: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEF-IVSSYDIEVLENQE 1388
LDRE + + L + DG P +ST T+ V D ND+AP F ++ V+E +
Sbjct: 637 KALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
Query: 1389 PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVI 1448
V V A+D DAG N V Y + GN + F I +G + T L+RE + LV+
Sbjct: 696 NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVV 752
Query: 1449 LCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEG 1508
+ +D PR S + L ++VLD +D+SP F Y V E+ GT +L + A D D G
Sbjct: 753 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 812
Query: 1509 LNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA----RSQHTFSAVARDCSIQGSRS 1564
N + + E F + P +G L +LD EA + TF A D I G+
Sbjct: 813 AN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMP 869
Query: 1565 TTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLG--PNGTVVFS 1621
+ + V V D+ND PV + + ++P++ V A+D D P V +
Sbjct: 870 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 929
Query: 1622 FAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIP---ARTTTGLLV 1672
+ Q S+F +++ +G + + N + E I+ L + D G P + T +LV
Sbjct: 930 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 989
Query: 1673 IHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVL 1731
+H GE + F+ Y+ V+E GT + + A A I S+ YSI SGNE+
Sbjct: 990 LH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTF 1043
Query: 1732 SLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES----------SGHRAYCKVAVLIQDEN 1781
+ + +G + V P LD+E R L V A+S KV + IQDEN
Sbjct: 1044 GINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
Query: 1782 DNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSIL---SGNQEEAFQID 1838
++ P F++ Y VSE V++V ATD D+G ++ Y ++ +E F ++
Sbjct: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
Query: 1839 ALSGVITTKAILDYELTSSYSLIVQATD---KGMPRLSNTTVIKVQVTD---INDNAPAF 1892
+G+I T + S + V ATD KG+ ++ V V D I N P
Sbjct: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1221
Query: 1893 LPSEAVE--------ITEDSLPGVIVTHVSVHDVDLNSAF-IFSFAK------ESNPGTK 1937
L + +E ++ +PG V S+ AF + + K +P T
Sbjct: 1222 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTN 1281
Query: 1938 FAIDQNTGVVVLVKTL-----DFE----------EMTEYELLIQI---SDSVHYTEGALV 1979
AID+N L L DF+ E+ E + I +S+ YTEGAL+
Sbjct: 1282 RAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALL 1341
Score = 266 bits (681), Expect = 2e-70
Identities = 300/1128 (26%), Positives = 480/1128 (42%), Gaps = 127/1128 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI--- 191
Query: 1312 ASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHA 1371
+ N D + L+ TL V V DG L V + D
Sbjct: 192 ------QYNPDDPDRAQN--LNERRTTTTTLTVDVLDGD--DLGPMFLPCVLVPNTRDCR 241
Query: 1372 PEFIVSSYDIEVLENQEPEVVYTVL------ASDMDAG-----NNRAVEYHIIDGNTDEC 1420
P +Y + E + PE + ++ A D D + + Y I+ G ++
Sbjct: 242 P----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
Query: 1421 ---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F ++ + ELS ++R+ F LVI P + L + +LD N+ SP
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
Query: 1478 FPTLYYQSSVREDAEVGTVV---------LVLSAVDKD--EGLNGQTEYFLTDEASGAFT 1526
F YQ + E A VG + L + A+DKD + + + FL D S FT
Sbjct: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-VFT 416
Query: 1527 IDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
+ T L +DRE + +TFS A D +Q S VI+ + V D NDN P
Sbjct: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ESEPVIVNIQVMDANDNTPTFP 473
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-AETQSMFSIDKYTGEIQFQQN 1643
+ +DV++ + + + + A D D G NG + + Q F I+K TG I
Sbjct: 474 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIA-- 531
Query: 1644 PSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME----GEDVKISFSHHLYKGLVTEN 1696
P E L ++ D PA + +++E F +Y ++E
Sbjct: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
Query: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756
G ++ ++A D DS+ Y+I +G+ V +L +G LT+ K LD E +
Sbjct: 592 MRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSETTGILTLG--KALDRESTDRY 647
Query: 1757 QLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
LI+ A + V +++ D NDN+P F+ + + + NA V QV ATD
Sbjct: 648 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 707
Query: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
D+G+NG + YS+ GN F+I + +G I T L+ E+ Y L+V ATD + +
Sbjct: 708 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
Query: 1875 TTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVDLNSAFIFSFAKESN 1933
T + ++V DI+DN+P F S + E++LP G + + DVDL + + +
Sbjct: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR---S 821
Query: 1934 PGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGAL-------VVRVLD 1984
P K FA+ TG + L+++LD+E + E I G + V V D
Sbjct: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
Query: 1985 VNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN----ENISYRILS-----SSKE 2035
+ND PPVFS+ Y+ V G + T+ A D + + YR+ +
Sbjct: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
Query: 2036 FSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPDLRALTLVEIGIEDMNNYAPE 2093
F ++ +G + T + L+ TT F +V A D G P + + V+I + P
Sbjct: 942 FEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PR 997
Query: 2094 FTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHS 2152
FT + Y +SE A G+ + S N + YSI+SGN ++ F +
Sbjct: 998 FTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVYSIVSGNEEDTFGINNI---- 1048
Query: 2153 EYPYKQVGYLVLLHSLDREASASH-------ELVILASDSGCPPLSSTAVISIQVLDVND 2205
G + + LD E S+ L ++ ++ P S+TA + I++ D N+
Sbjct: 1049 ------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
Query: 2206 NPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNII---SGNEKGHFYLEE 2262
+PP F Y V E + + + V A D+DTG+++ + Y +I K F +E
Sbjct: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
Query: 2263 NTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSVLDDND 2309
TG++ + + F V A+D K S A V VSV++ D
Sbjct: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 256 bits (653), Expect = 3e-67
Identities = 274/1054 (25%), Positives = 458/1054 (43%), Gaps = 107/1054 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SHNPG----TNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+NP + T +TV LD + + + L R R LT Q
Sbjct: 193 -YNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT-----RDCRPLTYQ 246
Query: 1153 IVILDV---NDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNEN 1209
I ++ + NP ++ P + +D + P R G + YSIL G
Sbjct: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNI----------QPPSDRPG-ILYSILVGTPE 295
Query: 1210 ---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1266
F + + L+ P++ + + L + A D L + L + +LD N+++
Sbjct: 296 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQS 355
Query: 1267 PVFKQHLYEASVKENQNPGEFVT---------RVEALDRDSGVNSKLQFEIMPGASFELF 1317
P F Y+ + E+ G ++ R+ ALD+D + + +F
Sbjct: 356 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 415
Query: 1318 EINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEF 1374
+ + TG T+L DRE Q+ +T + DG S + V D ND+ P F
Sbjct: 416 TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTF 472
Query: 1375 IVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTT 1433
SYD+ V + P + V + A D D G+N + Y I+ G + F IN+ +G ++
Sbjct: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 531
Query: 1434 RALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLDANDHS-PSFPTLYYQSSVRED 1490
++ + L + +D P R+S+ + + VL N+ S P FP L Y + E
Sbjct: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
Query: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTF 1550
VG V+L L A D++ + T + F + +G L LDRE+ ++
Sbjct: 592 MRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
Query: 1551 SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS-----PESPTNQTTVIV 1605
A D G+ + TV + VTDVNDN PV FD +L E N V
Sbjct: 650 IITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQV 702
Query: 1606 RADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGI--P 1663
+A D D G NG V +S ++F I G I + E + + V G P
Sbjct: 703 KATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHP 761
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIF 1723
+T L + ++ +D F++ Y LV EN AGT+I+ ++A D + ++ Y I
Sbjct: 762 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD-LGANVSYRIR 820
Query: 1724 SGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIVLAES-----SGHRAYCKVAVL 1776
S +L +G+L++ + LD+E E + L E+ + V V+
Sbjct: 821 SPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
Query: 1777 IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD-SGL-NGLIEY---SILSGNQ 1831
++D ND P F + IY+ V+ + + V+A D D GL + Y +
Sbjct: 879 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 938
Query: 1832 EEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPA 1891
F+++ SG + T+ L+ E T+ + L+V A D G P +S++ +K+ V + P
Sbjct: 939 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPR 997
Query: 1892 FLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVL 1949
F E ++E + G +V +S +N + ++S + T F I+ TGV+ +
Sbjct: 998 FTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDT-FGINNITGVIYV 1054
Query: 1950 VKTLDFEEMTEYELLIQISDSVHY-----------TEGALVVRVLDVNDNPPVFSQDFYQ 1998
LD+E T Y L +Q +DS+ + + + D N++PPVF + FY
Sbjct: 1055 NGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1113
Query: 1999 VTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
V E + SVL + ATD ++ ++YR++
Sbjct: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
Score = 247 bits (630), Expect = 1e-64
Identities = 274/1131 (24%), Positives = 481/1131 (42%), Gaps = 129/1131 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHIIDG 1415
V D ND++P F SY V N+ V T+ A+D+D G N +EY +I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQY 193
Query: 1416 NTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHS 1475
N D+ ++ +TT L + + DLG V+ V + D
Sbjct: 194 NPDDPDRAQNLNERRTTTTTLTVDVLDG-------DDLGPMFLPCVL-----VPNTRDCR 241
Query: 1476 PSFPTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLNGQTE-----YFLT----DEA 1521
P L YQ+++ R E+ +++ + A+D+D + ++ Y + ++
Sbjct: 242 P----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
Query: 1522 SGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI-IKVYVTDVNDND 1580
F + P + L ++R+ + F V + G + + + D N+
Sbjct: 298 PRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNGHPLPAFAGLHIEILDENNQS 355
Query: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM------FSIDKY 1634
P + ++ +P T +D L+L +V + + ++ Y
Sbjct: 356 PYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 411
Query: 1635 TGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIPARTTTGLLVIHMEGEDVKIS 1683
T Q + Y + + +Q G+ + + M+ D +
Sbjct: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471
Query: 1684 FSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
F Y V + G S++ + A A + + Y I G + G + +G +T+
Sbjct: 472 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITI 530
Query: 1743 KEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLIQDENDNSPC-FEQSIYQASV 1796
++ V L V A + + C V + + N+ SP F Q +Y +
Sbjct: 531 APG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 588
Query: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
SE+ A ++ + ATD + I Y+I +G+ + F + +G++T LD E T
Sbjct: 589 SEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 645
Query: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---LPSEAVEITEDSLPGVIVTHV 1913
Y LI+ A+D G P ++T + + VTD+NDNAP F LP + E++ V
Sbjct: 646 RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 704
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVH 1972
+ D +N +S +N F I N + VK L+ E YEL++ +D +VH
Sbjct: 705 TDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVH 760
Query: 1973 --YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL 2030
++ L ++VLD++DN PVF+ Y V V E++P G ++L + A D++ N+SYRI
Sbjct: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR 820
Query: 2031 SSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIE 2085
S + F++ P G + + + D ++ FLVEA D + V + ++
Sbjct: 821 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 880
Query: 2086 DMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR-ENTYVEYSIISGNSQNNFH 2144
DMN+Y P F+ + Y ++ DA+ G+ + T D D + V Y + F
Sbjct: 881 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV----DDVQFP 936
Query: 2145 VETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVN 2204
F E + G ++ +L+ E + +LV++A D G P +SS+A + I VL
Sbjct: 937 YPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 993
Query: 2205 DNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
+ P F+ Y V E G+ + V+SA + I+Y+I+SGNE+ F +
Sbjct: 994 EIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNI 1048
Query: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHFSFAVVFVSVLDDNDHAPQFM 2315
TGV+Y+ PLDYE T + L VQA E + A V++ + D+N+H P F
Sbjct: 1049 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1108
Query: 2316 FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL 2375
+ V E+ + +++ + A D D G Y + Y ++ P + + F+++
Sbjct: 1109 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP-----PIKEGKEGFVVETY 1163
Query: 2376 TGDIHAKQILDYENGNKYCLTVQAKD--------KGDATASLVVWVDIEGI 2418
TG I + + + V A D K D S+V +D++ I
Sbjct: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1214
Score = 244 bits (624), Expect = 7e-64
Identities = 291/1144 (25%), Positives = 474/1144 (41%), Gaps = 138/1144 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREH 579
Q DRA + E+R T TL + + + V++
Sbjct: 192 ---QYNPDDPDRAQNL---------NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 239
Query: 580 SPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAHPLGPQRAASPLRYSL---EPSVDSA 632
T++ + ++ E L+P +T +Q Q + P + YS+ P
Sbjct: 240 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 299
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 692
F + P T + L + + Q ++ + A ++G + + + DEN+ SP F
Sbjct: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPYF 358
Query: 693 -LHDVLFLKVEESPVPQGVIG--------KITAIDMD--SGKNGQLLYFLLSDGKFFKMN 741
+ +E +PV + +I A+D D K+ +L FL F +
Sbjct: 359 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT 418
Query: 742 PNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREH 801
TG + ++ D +E Q +
Sbjct: 419 -QTGITRYLTLLQPVD-------------REEQQTY------------------------ 440
Query: 802 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 861
T +T + + V + V D NDN P FP+ ++ + G V L
Sbjct: 441 ------TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 494
Query: 862 VTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIAT 921
A D DEG+N E+TY + D F I+ G I + +Y ++V A
Sbjct: 495 T----AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
Query: 922 DQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQ 978
D P + ++ V I+V+ P ++ Q + L I E ++ ++ ++++D
Sbjct: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD---- 605
Query: 979 HYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST 1038
+ ++I D F + +TG L L K LD E+T Y+ + +D + + ++T
Sbjct: 606 REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 665
Query: 1039 VFLSIDVEDQNDHSPSFQD----ELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYY 1094
V +I V D ND++P F L V+ E N +G + A D D +N ++ Y
Sbjct: 666 V--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV----KATDPDAG-INGQVHYS 718
Query: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
+ + N N F I S G++ T +L+RE L V A+D AV+ R +LT I
Sbjct: 719 LGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH---PRHSTLTLAIK 771
Query: 1155 ILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFM 1213
+LD++D++P F S V+E++ G+ + I A D D G N V+Y I S F
Sbjct: 772 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 829
Query: 1214 LDESSGLLTTTCPLDYE----MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF 1269
L +G L+ LDYE + V A D T+TV V D+ND PVF
Sbjct: 830 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 889
Query: 1270 KQHLYEASVKENQNPGEFVTRVEALDRD------SGVNSKLQFEIMPGASFELFEINSDT 1323
+ +Y+ V + G +T V A D D S V ++ P + +FE+ D+
Sbjct: 890 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDS 948
Query: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
G V+T L+ E +F L V+ D G P +SS+ T+ V + P F Y
Sbjct: 949 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPP 1007
Query: 1384 LENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISN 1443
+ E T++ A N+++ Y I+ GN ++ F IN ++G + LD E ++
Sbjct: 1008 V--SELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1065
Query: 1444 F-------TLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTV 1496
+ +L ++ ++L P +S+ + + + D N+H P F +Y V EDA + T
Sbjct: 1066 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1125
Query: 1497 VLVLSAVDKDEGLNGQTEYFL----TDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSA 1552
VL + A DKD G Y L E F ++ +G +KT+ RS F
Sbjct: 1126 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1185
Query: 1553 VARD 1556
+A D
Sbjct: 1186 IATD 1189
Score = 217 bits (553), Expect = 1e-55
Identities = 259/1095 (23%), Positives = 462/1095 (42%), Gaps = 129/1095 (11%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKT 1233
VG+ + A D D+G NG++ Y I ++ + + TTT
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTT--------- 212
Query: 1234 QHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF------------KQHLYEASVKEN 1281
TLTV VLD +D P+F + Y+A++ E
Sbjct: 213 --------------------TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Query: 1282 QNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEINSDTGEVVT 1328
+ P E ++A+D+D + + + I+ G + F ++ T E+
Sbjct: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
Query: 1329 TTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
++R+ + F L + +D G P L + + + DEN+ +P F + SY +LE+
Sbjct: 313 LEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESA 371
Query: 1388 EPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MSGELSTTRA 1435
+ ++A D D + + E H+ + FT+ + ++ L+ +
Sbjct: 372 PVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
Query: 1436 LDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGT 1495
+DRE+ +T I D S + + ++V+DAND++P+FP + Y V D G
Sbjct: 432 VDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 489
Query: 1496 VVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVAR 1555
V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++ + + A
Sbjct: 490 SVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
Query: 1556 DCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL 1612
D + R TV I+V + N + P Q + + +S + ++A D +
Sbjct: 550 DNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE- 607
Query: 1613 GPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLL- 1671
G + T + Q +F++ + TG + + E ++ + G P T+T +
Sbjct: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN 667
Query: 1672 VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGV 1730
++ + D F +L + L EA + VKA PD+ I + YS+ GN + +
Sbjct: 668 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 725
Query: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCF 1787
+ S T + L+ EVR+ +L+V+A + +A+ + D +DNSP F
Sbjct: 726 FRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 782
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
S Y V E+ ++Q+ A D+D G N + Y I S + F + +G ++
Sbjct: 783 TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 840
Query: 1848 AILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV---EI 1900
LDYE +S + +V+A D + V V D+ND P F S+ + +
Sbjct: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--SKRIYKGMV 898
Query: 1901 TEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLD 1954
D++ G +T V D D + + P + F +++++G V+ L+
Sbjct: 899 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 958
Query: 1955 FEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSV 2011
E T ++L++ D V + + + VL + P +++ V E G V
Sbjct: 959 EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMV 1018
Query: 2012 LTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDG 2069
+SA + N++I Y I+S ++E F I+ G I+ P LD + T +++
Sbjct: 1019 GVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTSYVLRVQAD 1073
Query: 2070 G---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNID 2120
P V I I+D NN+ P F K Y +SEDA + ++++ D
Sbjct: 1074 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1133
Query: 2121 HDWTRENTYVEYSII 2135
D T + + Y +I
Sbjct: 1134 KD-TGNYSVMAYRLI 1147
Score = 212 bits (539), Expect = 5e-54
Identities = 282/1097 (25%), Positives = 462/1097 (42%), Gaps = 111/1097 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDRE 1543
E VGT + A D D+G NGQ EY + ++ T+ TL +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD 217
Query: 1544 ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPE--SPTNQT 1601
+ C V V + D P+ Q +PE +P T
Sbjct: 218 VLDGDDLGPMFLPC-------------VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVT 264
Query: 1602 TVIVRAD-DLDLGPNGT---VVFSFA-----ETQSMFSIDKYTGEIQFQQNPSSEYFPIW 1652
I D D ++ P +++S + F + T E+ + + ++ +
Sbjct: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
Query: 1653 -LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG---------T 1701
L +K D G P GL + ++ + F+ Y+G + E+ G T
Sbjct: 325 DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
Query: 1702 SIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCSK--SGQLTVKEPKFLDFEVRNEVQ 1757
S + + A D I+D+ + +F + V ++ + LT+ +P +D E +
Sbjct: 385 SPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYT 441
Query: 1758 LIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS 1816
+ A + + + + D NDN+P F + Y V VIQ+ A D D
Sbjct: 442 FSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
Query: 1817 GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP--RLSN 1874
G NG I Y IL G Q + F I+ +G+IT ++ + +Y+L VQA D P R ++
Sbjct: 502 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 560
Query: 1875 TTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKES 1932
+ ++V N+ +P P ++EI+E G ++ ++ D + +S ++A E+
Sbjct: 561 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 617
Query: 1933 -NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVL--DVNDNP 1989
+P F + + TG++ L K LD E Y L+I SD V ++ DVNDN
Sbjct: 618 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 677
Query: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPKNGTIFT 2047
PVF + V + ATD ++ N + Y + + + F I NG+I+T
Sbjct: 678 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT 736
Query: 2048 ISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSED 2106
+ L + + +V A+DG +P LTL I + D+++ +P FT +Y + + E+
Sbjct: 737 -AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEEN 794
Query: 2107 ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLH 2166
G+T++ D D V Y I S E K F + +P+ G L LL
Sbjct: 795 LPAGTTILQIEAKDVDL---GANVSYRIRSP--------EVKHFFALHPF--TGELSLLR 841
Query: 2167 SLDREA----SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222
SLD EA AS ++ A D A +++ V D+ND PP FS Y V
Sbjct: 842 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 901
Query: 2223 TPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH----FYLEENTGVLYLIKPLDYEK 2277
G+ IT V A D D G A + + + + F +EE++G + L+ E
Sbjct: 902 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 961
Query: 2278 MTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSI 2336
T F L V A D E S A V + VL + P+F + L T+ +
Sbjct: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1020
Query: 2337 NALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLT 2396
+ A + YSIVS + D F I+ +TG I+ LDYE Y L
Sbjct: 1021 ISA---AAINQSIVYSIVS--------GNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1069
Query: 2397 VQAKDKGDATASL---------VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRV 2447
VQA A+L V+++I+ + P+F + Y + E + + RV
Sbjct: 1070 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
Query: 2448 EASDADAGIDGVILYSL 2464
+A+D D G V+ Y L
Sbjct: 1130 KATDKDTGNYSVMAYRL 1146
Score = 209 bits (531), Expect = 4e-53
Identities = 279/1117 (24%), Positives = 463/1117 (41%), Gaps = 109/1117 (9%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA-------ETQSMFSIDKYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + Q++ T +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGD 222
Query: 1647 EYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTV 1706
+ P++L + R T I ++ L +VT +A I
Sbjct: 223 DLGPMFLPCVLVPNTRDCRPLTYQAAIP------ELRTPEELNPIIVTPPIQA---IDQD 273
Query: 1707 KAFAPDSIQDSMKYSIFSGNEDGV---LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
+ P S + + YSI G + + ++ +L++ EP DF + L++ AE
Sbjct: 274 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 331
Query: 1764 S-SGHR--AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHV---------IQVFA 1811
+GH A+ + + I DEN+ SP F YQ + ES A + +++ A
Sbjct: 332 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 391
Query: 1812 TDLDSGLNGLIEYSILSGNQEEAFQID--ALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
D D E + + F + ++ +T +D E +Y+ + A D G+
Sbjct: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV 450
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLP-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
S ++ +QV D NDN P F S V + D PG V ++ D D S ++
Sbjct: 451 QE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 509
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG-----ALVVRVL 1983
F I++ TG++ + ++ Y L +Q +D+ E + + VL
Sbjct: 510 EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
Query: 1984 DVND-NPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDP 2040
N+ +PP F Q Y + + E++ VG +L L ATD E ++I+Y I + + F++
Sbjct: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSE 628
Query: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSY 2099
G I T+ L ++ ++ ASDG PD + V I + D+N+ AP F
Sbjct: 629 TTG-ILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPR 686
Query: 2100 NLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
NLS+ E+ A VG T D D N V YS+ GN N F + +
Sbjct: 687 NLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL--GNFNNLFRITSN-------- 731
Query: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
G + L+RE +ELV++A+D P ST ++I+VLD++DN P F++ +Y
Sbjct: 732 ---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 788
Query: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
V+E+ P G+ I + A D D G A + Y I S K F L TG L L++ LDYE
Sbjct: 789 VLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 846
Query: 2277 ----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
+ T V+A D A V V V D ND+ P F + +V + +
Sbjct: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
Query: 2332 TICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN 2389
I ++ A D D P + Y + F Y +F ++ +G + + L+ E
Sbjct: 907 PITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPASIFEVEEDSGRVITRVNLNEEP 961
Query: 2390 GNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
+ L V A D G+ S V I + E P FTQ++Y P + G +
Sbjct: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY---RPPPVSELATKGTMV 1018
Query: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKII 2504
+ A I+ I+YS+ G F +N G IY+ L S + + ++++
Sbjct: 1019 GVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1078
Query: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
+ + SK + V++ + + P VF F I
Sbjct: 1079 LANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1113
Score = 206 bits (523), Expect = 4e-52
Identities = 284/1173 (24%), Positives = 462/1173 (39%), Gaps = 166/1173 (14%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAYELI 217
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 218 -----PGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERD 272
P +L +TT + V++L + MFLP + V
Sbjct: 193 YNPDDPDRAQNLNERRTTTTTLT--VDVLDGDDLGP---------MFLPCVL----VPNT 237
Query: 273 EEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYL- 331
+ ++A+ + L+ + V + D + + ++ IL ++
Sbjct: 238 RDCRPLTYQAA---IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 294
Query: 332 ------------TLPLSHLESTT------LSLMVSAQDGGGLTAVINADVTIHIFQTTLA 373
T LS LE L++ A+ G A + I I
Sbjct: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 354
Query: 374 PAEFERPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGK 423
F P Y + E P SP+ V + + ++ + D
Sbjct: 355 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 414
Query: 424 FSIHPRLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480
F++ + G R +P+D E Q ++ A G + VNI VMD NDN P F
Sbjct: 415 FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTF 472
Query: 481 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540
S ++ + PG ++ A D D G NG I Y I G F I++ G++ +
Sbjct: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 532
Query: 541 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSES 597
+ R LT++A D + + TV IE SP F L+Y +E+SE+
Sbjct: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEA 591
Query: 598 LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTY 657
+ +L QA R + Y++E +F + TG + L + D EST Y
Sbjct: 592 MRVGAVLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 647
Query: 658 NFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGK 713
+ A DG ST TV + V D NDN+P F L L + EE+ +G+
Sbjct: 648 ILIITA---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQ 701
Query: 714 ITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDE 773
+ A D D+G NGQ+ Y L + F++ N G+IY
Sbjct: 702 VKATDPDAGINGQVHYSLGNFNNLFRITSN----GSIYTA-------------------- 737
Query: 774 LQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 833
V L+RE R ++E+ V+ TD PR++T+ + + V DI+
Sbjct: 738 ---------------------VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 776
Query: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
DN P F V V E P + + AKD D G A V+Y + S + F +
Sbjct: 777 DNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFAL 830
Query: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQG------VPPLQGQAVVNIQVIPLSKGRAI 947
GE+ L Y+ P S+ + +PP G A V + V ++ +
Sbjct: 831 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPV 888
Query: 948 MSQNI-RHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD-----GHFEIDS 1001
S+ I + ++ P+ +K T I ++ ++ + + DD FE++
Sbjct: 889 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV--DDVQFPYPASIFEVEE 946
Query: 1002 STGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIV 1061
+G + L+ E T+ + V+ D + + +SS+ + I V + Q+E
Sbjct: 947 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGEIPRFTQEEYRP 1005
Query: 1062 ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLD 1121
V E GT+V V +A + +N I Y I S N + F I+ G + LD
Sbjct: 1006 PPVSELATKGTMVGVISA-----AAINQSIVYSIVSGNE-EDTFGINNITGVIYVNGPLD 1059
Query: 1122 RESIPTVILTVTASDQAVNVTDRRL--RSLTAQ--IVILDVNDHNPTF-ISFPNAHVKED 1176
E+ + +L V A V + + R+ +S TA+ I I D N+H P F F V ED
Sbjct: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1119
Query: 1177 VTVGSLVHHITAHDPDEGRNGKVTYSIL-----SGNENMTFMLDESSGLLTTTCPLDYEM 1231
+ + V + A D D G + Y ++ G E F+++ +GL+ T
Sbjct: 1120 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMR 1177
Query: 1232 KTQHILTVLALDDGTPALSSSQTLTVTVLDVND 1264
++ V+A DD LS + V+V++ D
Sbjct: 1178 RSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 201 bits (511), Expect = 9e-51
Identities = 292/1238 (23%), Positives = 501/1238 (40%), Gaps = 182/1238 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
SP TF+H Y V+E L+P+ + T +S + G
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTG--------------FSGDNGATDIDDGPNGQ 186
Query: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF- 698
++ D + Q N R + +TT+ V V D +D P FL VL
Sbjct: 187 IEYVIQYNPDDPDRAQNLNER-----------RTTTTTLTVDVLDGDDLGPMFLPCVLVP 235
Query: 699 ----------------LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP 742
L+ E P V I AID D + P
Sbjct: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN-----------------IQP 278
Query: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
+ G +Y I GT D + F + EL E +N R+
Sbjct: 279 PSDRPGILYSI--------LVGTP----EDYPRFFHMHPRTAELSLLEPVN-----RDFH 321
Query: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
++ + P A +++ + D N+ P+F +P + ++ LE PV +
Sbjct: 322 QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT--MPSYQGYI--LESAPVGATI 377
Query: 863 TT---------VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILS---YDY 910
+ + A D D + + + D + F + G R T+L +
Sbjct: 378 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREE 436
Query: 911 RPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLI 970
+ +Y S+ A D GV + +VNIQV+ + + + + +++P + +
Sbjct: 437 QQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 494
Query: 971 KSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHS 1030
+ D + NG++ + I+ + G F I+ +TG + ++ ++ Y V D++
Sbjct: 495 TAVD-ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 552
Query: 1031 ---KNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ + TV++ + + N P F + + + E + +G ++ A D +G
Sbjct: 553 PPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD-- 609
Query: 1088 NSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLR 1147
I Y IE+ +P F + + G L LDRES IL +TASD + T
Sbjct: 610 --SITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS---- 662
Query: 1148 SLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILS 1205
+ T IV+ DVND+ P F + N V E+ + V + A DPD G NG+V YS+
Sbjct: 663 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL-- 719
Query: 1206 GNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
GN N F + S+G + T L+ E++ + L V+A D S+ TL + VLD++D
Sbjct: 720 GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 778
Query: 1266 APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGE 1325
+PVF Y V+EN G + ++EA D D G N + + I F ++ TGE
Sbjct: 779 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGE 836
Query: 1326 VVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
+ L D+E F + G P +T T++ V+D ND+ P F Y
Sbjct: 837 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIY 894
Query: 1380 DIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---TDECFTINEMSGELSTT 1433
V + + + TV A D D A V Y + D F + E SG + T
Sbjct: 895 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 954
Query: 1434 RALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEV 1493
L+ E + F LV++ D G+P SS +++ VL + Y V E A
Sbjct: 955 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATK 1014
Query: 1494 GTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSA 1552
GT+V V+SA +N Y ++ F I+ ++G + + LD E R+ +
Sbjct: 1015 GTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
Query: 1553 VARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606
A + S+S T + + + D N++ PV ++ + +S ++ + + V+
Sbjct: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
Query: 1607 ADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
A D D G + + E + F ++ YTG I+
Sbjct: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1168
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 430 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 476
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 535
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 536 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 594
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 652
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 653 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 703
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 704 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 760
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 818
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 819 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 879 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 934
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 992
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 993 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1045
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1046 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1073
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1074 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1123
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1124 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1183
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1184 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1237
Query: 977 QQ 978
Q
Sbjct: 1238 VQ 1239
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 701 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 751
Query: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 752 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 801 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 854
Query: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
+ + P + + +D F +KG +K
Sbjct: 855 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 909
Query: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 910 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
Query: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 970 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 1023
Query: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 1024 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
Query: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
Query: 514 LIRYSIASP 522
++ Y + P
Sbjct: 1141 VMAYRLIIP 1149
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 998 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1057
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1058 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1113
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
Score = 54.3 bits (129), Expect = 2e-06
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 18/144 (12%)
Query: 92 IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLA 151
I Y++ +G + + F + G + + + +DRE Y L++ A DG
Sbjct: 611 ITYAIENG----DPQRVFNLSETTGILTLGKALDRESTDR-YILIITASDGRPDG----- 660
Query: 152 LVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 211
++ A V + + DVNDN PVF+P E + + V ATD D+GI G
Sbjct: 661 ------TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 714
Query: 212 VAYELIPGNVSSLFTIDSTTGLYS 235
V Y L GN ++LF I S +Y+
Sbjct: 715 VHYSL--GNFNNLFRITSNGSIYT 736
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1240 VSVVNQLD 1247
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1241 SVVNQLDMQVI 1251
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
Query: 2536 ASSFSI 2541
F I
Sbjct: 1145 QKKFYI 1150
Score = 212 bits (539), Expect = 5e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
Query: 1263 ND 1264
D
Sbjct: 1246 LD 1247
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 434 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 548 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 662
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 663 LSETTG------ILT-------------------------------LGK-------ALDR 678
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 679 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 733
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 790
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 847
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 848 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 906
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1023
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1138
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1139 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1198
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1258
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1259 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1316
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1317 TNRAIDRNELFKF 1329
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
Query: 977 QQ 978
Q
Sbjct: 1275 VQ 1276
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 111 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 167 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 345
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 398
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 459 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 512
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 513 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 571
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 572 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 628
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 687
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 688 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 745
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 746 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 804
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 805 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 864 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1038
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1039 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1093
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1214 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1273
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1274 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1333
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1334 TPEAVTSIKKRGESLGYTEGALL 1356
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 353 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 413 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 468
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 529 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 644
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 645 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 820 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 877 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 936
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 937 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 993
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 994 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1047
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1048 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1158 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1217
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1218 VSVVNQLD 1225
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 170
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 527 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 585
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 586 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 643
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 644 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 696
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 755
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 816 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 872
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 993 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1049
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1050 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1107
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1108 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 115 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 350
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 406
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 527 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 640
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 755
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 816 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 936 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 989 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1043
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1163
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1164 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1219 SVVNQLDMQVI 1229
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 348
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 454
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 455 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 484
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 485 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 539
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 600 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 655
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 656 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 714 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 764
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 765 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 822 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 880 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 940 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 999 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1055
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1056 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1176 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 81 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 139
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 140 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 199
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 200 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 259
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 319
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 320 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 378
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 379 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 438
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 439 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 556
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 557 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 615
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 616 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 674
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 735 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 847
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 848 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 905
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1026 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1080
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1141 VLRVKATDKD-TGNYSVMAYRLI 1162
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 434
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 435 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 492
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 493 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 551
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 552 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 611
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 612 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 668
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 669 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 729 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 785
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 837
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 838 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1011
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1012 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1060
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1061 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1120
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1121 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
Score = 212 bits (540), Expect = 4e-54
Identities = 289/1117 (25%), Positives = 466/1117 (41%), Gaps = 129/1117 (11%)
Query: 1514 EYFLTDEASGAFTIDPMSGTL---KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI-- 1568
E L D +DP+ L T LDR+ + S V + I T +
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHE 110
Query: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR------ADDLDLGPNGTVVFSF 1622
+++ V D NDN P + + ++ +P TT+ A D+D GPNG + +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVG-TTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1623 A------ETQSMFSID-KYTGEIQFQQNPSSE----YFPIWLQLKVTDQGIPAR--TTTG 1669
+ F I TG I ++ + E YF I +Q Q + R TTT
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQANDRAQNLNERRTTTTT 228
Query: 1670 LLVIHMEGEDVKISFSHHL------------YKGLVTENC---EAGTSIVTVKAFA---- 1710
L V ++G+D+ F + Y+ + E E IVT A
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 1711 ----PDSIQDSMKYSIFSGNEDGV---LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
P S + + YSI G + + ++ +L++ EP DF + L++ AE
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 346
Query: 1764 S-SGHR--AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHV---------IQVFA 1811
+GH A+ + + I DEN+ SP F YQ + ES A + +++ A
Sbjct: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1812 TDLDSGLNGLIEYSILSGNQEEAFQID--ALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
D D E + + F + ++ +T +D E +Y+ + A D G+
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV 465
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLP-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
S ++ +QV D NDN P F S V + D PG V ++ D D S ++
Sbjct: 466 QE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG-----ALVVRVL 1983
F I++ TG++ + ++ Y L +Q +D+ E + + VL
Sbjct: 525 EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 1984 DVND-NPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDP 2040
N+ +PP F Q Y + + E++ VG +L L ATD E ++I+Y I + + F++
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSE 643
Query: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSY 2099
G I T+ L ++ ++ ASDG PD + V I + D+N+ AP F
Sbjct: 644 TTG-ILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPR 701
Query: 2100 NLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
NLS+ E+ A VG T D D N V YS+ GN N F + +
Sbjct: 702 NLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL--GNFNNLFRITSN-------- 746
Query: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
G + L+RE +ELV++A+D P ST ++I+VLD++DN P F++ +Y
Sbjct: 747 ---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
Query: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
V+E+ P G+ I + A D D G A + Y I S K F L TG L L++ LDYE
Sbjct: 804 VLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 861
Query: 2277 ----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
+ T V+A D A V V V D ND+ P F + +V + +
Sbjct: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 2332 TICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN 2389
I ++ A D D P + Y + F Y +F ++ +G + + L+ E
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPASIFEVEEDSGRVITRVNLNEEP 976
Query: 2390 GNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
+ L V A D G+ S V I + E P FTQ++Y P + G +
Sbjct: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY---RPPPVSELATKGTMV 1033
Query: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKII 2504
+ A I+ I+YS+ G F +N G IY+ L S + + ++++
Sbjct: 1034 GVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
Query: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
+ + SK + V++ + + P VF F I
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1128
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 341 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 459
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 460 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 579 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 633
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 690
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 691 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 746
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 747 ---GSIYTA-----------------------------------------VKLNREVRDY 762
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 818
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 819 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 877 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 934
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 935 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 993 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1046
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1047 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1105
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1106 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1165
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1166 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1223
Query: 1263 ND 1264
D
Sbjct: 1224 LD 1225
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 412 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 468
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 469 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 525
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 526 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 640
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 641 LSETTG------ILT-------------------------------LGK-------ALDR 656
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 657 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 711
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 712 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 768
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 825
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 826 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 884
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1001
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1056
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1116
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1117 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1176
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1177 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1236
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1237 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1294
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1295 TNRAIDRNELFKF 1307
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 440 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 497
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 498 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 556
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 557 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 616
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 617 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 674 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 722
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 723 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 776
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 837 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 882
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 883 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 916
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 917 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 972
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 973 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1032
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1033 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 445 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 491
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 550
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 551 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 609
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 667
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 668 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 718
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 719 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 775
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 776 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 833
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 834 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 893
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 894 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 949
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1007
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1008 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1060
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1061 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1088
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1089 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1138
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1139 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1252
Query: 977 QQ 978
Q
Sbjct: 1253 VQ 1254
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 508 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 561
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 562 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 612
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 613 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 670 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 714
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 715 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 769
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 828
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 829 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 888
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 889 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 945
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 946 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1005
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1006 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1056
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1013 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1072
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1073 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1128
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1181
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 167
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1240 VSVVNQLD 1247
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1241 SVVNQLDMQVI 1251
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
Query: 2536 ASSFSI 2541
F I
Sbjct: 1145 QKKFYI 1150
Score = 212 bits (539), Expect = 5e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
Query: 1263 ND 1264
D
Sbjct: 1246 LD 1247
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 434 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 548 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 662
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 663 LSETTG------ILT-------------------------------LGK-------ALDR 678
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 679 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 733
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 790
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 847
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 848 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 906
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1023
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1138
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1139 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1198
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1258
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1259 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1316
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1317 TNRAIDRNELFKF 1329
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
Query: 977 QQ 978
Q
Sbjct: 1275 VQ 1276
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 138 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 193
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 194 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 253
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 254 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 313
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 314 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 372
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 425
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 426 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 485
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 486 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 539
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 540 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 598
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 599 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 655
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 656 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 714
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 715 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 772
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 773 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 831
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 832 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 891 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1065
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1066 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1120
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1240
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1241 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1300
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1301 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1360
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1361 TPEAVTSIKKRGESLGYTEGALL 1383
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 380 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 440 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 495
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 496 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 555
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 556 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 613
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 614 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 671
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 672 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 729
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 786
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 847 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 903
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 904 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 963
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 964 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1021 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1074
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1075 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1124
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1125 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1184
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1185 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1244
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1245 VSVVNQLD 1252
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 197
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 437 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 493
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 554 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 612
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 613 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 670
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 671 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 723
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 782
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 843 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 899
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 900 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1020 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1076
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1077 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1134
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1135 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 142 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 377
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 433
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 554 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 667
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 668 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 727 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 782
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 843 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 903 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 963 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1016 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1070
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1071 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1130
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1131 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1190
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1191 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1245
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1246 SVVNQLDMQVI 1256
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 375
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 481
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 482 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 511
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 512 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 566
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 567 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 626
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 627 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 682
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 683 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 741 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 791
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 792 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 848
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 849 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 906
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 907 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 966
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 967 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1025
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1026 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1082
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1083 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1142
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1202
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1203 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 108 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 167 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 226
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 227 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 347 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 405
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 406 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 465
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 466 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 523
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 524 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 583
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 584 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 643 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 701
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 702 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 761
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 762 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 816
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 817 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 874
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 875 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 932
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 933 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 992
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 993 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1052
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1053 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1107
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1108 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1167
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1168 VLRVKATDKD-TGNYSVMAYRLI 1189
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 461
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 462 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 519
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 520 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 578
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 579 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 638
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 639 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 695
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 696 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 755
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 756 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 812
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 813 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 864
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 865 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 919
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 920 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 979
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 980 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1038
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1039 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1087
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1088 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1147
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1148 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1188
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 50 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 109
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 110 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 168
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 169 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 227
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 228 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 347 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 404
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 464
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 465 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 522
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 523 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 582
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 583 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 643 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 699
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 700 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 754
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 755 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 801
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 802 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 859
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 860 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 919
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 920 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 977
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 978 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1035 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1091
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1092 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1149
Query: 2536 ASSFSI 2541
F I
Sbjct: 1150 QKKFYI 1155
Score = 210 bits (535), Expect = 1e-53
Identities = 302/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
++ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 35 EDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 89
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 90 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 149 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 206 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 316
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 317 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 352
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 353 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 405
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 406 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 462
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 463 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 520
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 521 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 578
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 579 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 637
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 638 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 692
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 693 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 747
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 748 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 804
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 805 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 862
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 863 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 920
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 921 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 980
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 981 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1040
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1041 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1096
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1097 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1156
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1157 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1210
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 368 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 428 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 486
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 487 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 545
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 546 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 606 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 660
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 717
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 718 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 773
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 774 ---GSIYTA-----------------------------------------VKLNREVRDY 789
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 790 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 845
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 846 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 903
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 904 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 961
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 962 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1020 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1073
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1074 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1132
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1133 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1192
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1193 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1250
Query: 1263 ND 1264
D
Sbjct: 1251 LD 1252
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 439 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 495
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 496 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 552
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 553 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 611
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 612 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 667
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 668 LSETTG------ILT-------------------------------LGK-------ALDR 683
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 684 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 738
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 739 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 795
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 852
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 853 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 911
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 912 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 971
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1028
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1029 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1083
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1084 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1143
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1144 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1203
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1204 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1263
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1264 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1321
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1322 TNRAIDRNELFKF 1334
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 467 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 524
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 525 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 583
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 584 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 643
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 644 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 700
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 701 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 749
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 750 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 803
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 804 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 863
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 864 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 909
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 910 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 943
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 944 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 999
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 1000 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1060 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1114
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1115 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1174
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1175 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1211
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 472 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 518
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 519 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 577
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 578 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 636
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 637 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 694
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 695 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 745
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 746 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 802
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 803 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 860
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 861 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 920
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 921 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 976
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 977 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1034
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1035 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1087
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1088 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1115
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1116 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1165
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1166 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1225
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1226 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1279
Query: 977 QQ 978
Q
Sbjct: 1280 VQ 1281
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 535 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 588
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 589 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 639
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 640 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 696
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 697 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 741
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 742 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 796
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 797 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 855
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 856 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 915
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 916 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 972
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 973 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1032
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1033 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1083
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1084 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1142
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1040 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1099
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1100 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1155
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1208
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 194
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1240 VSVVNQLD 1247
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1241 SVVNQLDMQVI 1251
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
Query: 2536 ASSFSI 2541
F I
Sbjct: 1145 QKKFYI 1150
Score = 212 bits (539), Expect = 5e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
Query: 1263 ND 1264
D
Sbjct: 1246 LD 1247
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 434 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 548 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 662
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 663 LSETTG------ILT-------------------------------LGK-------ALDR 678
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 679 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 733
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 790
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 847
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 848 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 906
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1023
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1138
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1139 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1198
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1258
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1259 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1316
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1317 TNRAIDRNELFKF 1329
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
Query: 977 QQ 978
Q
Sbjct: 1275 VQ 1276
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 111 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 167 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 345
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 398
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 459 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 512
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 513 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 571
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 572 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 628
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 687
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 688 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 745
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 746 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 804
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 805 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 864 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1038
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1039 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1093
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1214 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1273
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1274 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1333
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1334 TPEAVTSIKKRGESLGYTEGALL 1356
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 353 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 413 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 468
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 529 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 644
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 645 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 820 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 877 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 936
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 937 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 993
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 994 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1047
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1048 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1158 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1217
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1218 VSVVNQLD 1225
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 170
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 527 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 585
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 586 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 643
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 644 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 696
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 755
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 816 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 872
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 993 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1049
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1050 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1107
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1108 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 115 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 350
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 406
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 527 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 640
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 755
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 816 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 936 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 988
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 989 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1043
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1163
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1164 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1219 SVVNQLDMQVI 1229
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 348
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 454
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 455 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 484
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 485 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 539
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 600 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 655
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 656 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 714 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 764
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 765 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 822 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 880 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 940 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 999 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1055
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1056 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1176 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 81 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 139
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 140 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 199
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 200 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 259
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 319
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 320 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 378
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 379 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 438
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 439 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 556
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 557 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 615
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 616 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 674
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 735 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 847
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 848 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 905
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1026 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1080
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1141 VLRVKATDKD-TGNYSVMAYRLI 1162
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 434
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 435 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 492
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 493 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 551
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 552 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 611
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 612 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 668
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 669 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 729 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 785
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 837
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 838 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1011
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1012 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1060
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1061 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1120
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1121 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
Score = 212 bits (540), Expect = 4e-54
Identities = 289/1117 (25%), Positives = 466/1117 (41%), Gaps = 129/1117 (11%)
Query: 1514 EYFLTDEASGAFTIDPMSGTL---KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI-- 1568
E L D +DP+ L T LDR+ + S V + I T +
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHE 110
Query: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR------ADDLDLGPNGTVVFSF 1622
+++ V D NDN P + + ++ +P TT+ A D+D GPNG + +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVG-TTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1623 A------ETQSMFSID-KYTGEIQFQQNPSSE----YFPIWLQLKVTDQGIPAR--TTTG 1669
+ F I TG I ++ + E YF I +Q Q + R TTT
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQANDRAQNLNERRTTTTT 228
Query: 1670 LLVIHMEGEDVKISFSHHL------------YKGLVTENC---EAGTSIVTVKAFA---- 1710
L V ++G+D+ F + Y+ + E E IVT A
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 1711 ----PDSIQDSMKYSIFSGNEDGV---LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
P S + + YSI G + + ++ +L++ EP DF + L++ AE
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 346
Query: 1764 S-SGHR--AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHV---------IQVFA 1811
+GH A+ + + I DEN+ SP F YQ + ES A + +++ A
Sbjct: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 1812 TDLDSGLNGLIEYSILSGNQEEAFQID--ALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
D D E + + F + ++ +T +D E +Y+ + A D G+
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV 465
Query: 1870 PRLSNTTVIKVQVTDINDNAPAFLP-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
S ++ +QV D NDN P F S V + D PG V ++ D D S ++
Sbjct: 466 QE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG-----ALVVRVL 1983
F I++ TG++ + ++ Y L +Q +D+ E + + VL
Sbjct: 525 EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 1984 DVND-NPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDP 2040
N+ +PP F Q Y + + E++ VG +L L ATD E ++I+Y I + + F++
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSE 643
Query: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSY 2099
G I T+ L ++ ++ ASDG PD + V I + D+N+ AP F
Sbjct: 644 TTG-ILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPR 701
Query: 2100 NLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
NLS+ E+ A VG T D D N V YS+ GN N F + +
Sbjct: 702 NLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL--GNFNNLFRITSN-------- 746
Query: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
G + L+RE +ELV++A+D P ST ++I+VLD++DN P F++ +Y
Sbjct: 747 ---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
Query: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
V+E+ P G+ I + A D D G A + Y I S K F L TG L L++ LDYE
Sbjct: 804 VLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 861
Query: 2277 ----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
+ T V+A D A V V V D ND+ P F + +V + +
Sbjct: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 2332 TICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN 2389
I ++ A D D P + Y + F Y +F ++ +G + + L+ E
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPASIFEVEEDSGRVITRVNLNEEP 976
Query: 2390 GNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
+ L V A D G+ S V I + E P FTQ++Y P + G +
Sbjct: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY---RPPPVSELATKGTMV 1033
Query: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKII 2504
+ A I+ I+YS+ G F +N G IY+ L S + + ++++
Sbjct: 1034 GVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
Query: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
+ + SK + V++ + + P VF F I
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1128
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 341 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 459
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 460 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 579 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 633
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 690
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 691 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 746
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 747 ---GSIYTA-----------------------------------------VKLNREVRDY 762
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 818
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 819 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 877 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 934
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 935 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 993 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1046
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1047 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1105
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1106 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1165
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1166 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1223
Query: 1263 ND 1264
D
Sbjct: 1224 LD 1225
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 412 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 468
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 469 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 525
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 526 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 640
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 641 LSETTG------ILT-------------------------------LGK-------ALDR 656
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 657 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 711
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 712 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 768
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 825
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 826 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 884
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1001
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1056
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1116
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1117 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1176
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1177 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1236
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1237 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1294
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1295 TNRAIDRNELFKF 1307
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 440 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 497
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 498 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 556
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 557 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 616
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 617 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 674 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 722
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 723 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 776
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 837 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 882
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 883 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 916
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 917 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 972
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 973 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1032
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1033 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 445 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 491
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 550
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 551 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 609
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 667
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 668 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 718
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 719 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 775
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 776 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 833
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 834 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 893
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 894 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 949
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1007
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1008 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1060
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1061 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1088
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1089 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1138
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1139 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1252
Query: 977 QQ 978
Q
Sbjct: 1253 VQ 1254
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 508 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 561
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 562 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 612
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 613 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 670 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 714
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 715 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 769
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 828
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 829 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 888
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 889 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 945
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 946 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1005
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1006 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1056
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1013 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1072
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1073 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1128
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1181
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 167
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1240 VSVVNQLD 1247
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1241 SVVNQLDMQVI 1251
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
Query: 2536 ASSFSI 2541
F I
Sbjct: 1145 QKKFYI 1150
Score = 212 bits (539), Expect = 5e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
Query: 1263 ND 1264
D
Sbjct: 1246 LD 1247
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 434 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 548 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 662
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 663 LSETTG------ILT-------------------------------LGK-------ALDR 678
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 679 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 733
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 790
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 847
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 848 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 906
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1023
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1138
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1139 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1198
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1258
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1259 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1316
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1317 TNRAIDRNELFKF 1329
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
Query: 977 QQ 978
Q
Sbjct: 1275 VQ 1276
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1240 VSVVNQLD 1247
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1241 SVVNQLDMQVI 1251
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
Query: 2536 ASSFSI 2541
F I
Sbjct: 1145 QKKFYI 1150
Score = 212 bits (539), Expect = 5e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
Query: 1263 ND 1264
D
Sbjct: 1246 LD 1247
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 434 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 548 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 662
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 663 LSETTG------ILT-------------------------------LGK-------ALDR 678
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 679 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 733
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 734 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 790
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 847
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 848 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 906
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1023
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1138
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1139 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1198
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1258
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1259 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1316
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1317 TNRAIDRNELFKF 1329
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
Query: 977 QQ 978
Q
Sbjct: 1275 VQ 1276
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 281 bits (720), Expect = 5e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 138 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 193
Query: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 194 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 253
Query: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
+ + G ++ N R L PE L P + I++ D
Sbjct: 254 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 313
Query: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 314 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 372
Query: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 425
Query: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 426 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 485
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 486 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 539
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 540 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 598
Query: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 599 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 655
Query: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 656 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 714
Query: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 715 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 772
Query: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 773 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 831
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 832 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 890
Query: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 891 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1065
Query: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1066 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1120
Query: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1240
Query: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1241 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1300
Query: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1301 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1360
Query: 1960 EYELLIQI---SDSVHYTEGALV 1979
E + I +S+ YTEGAL+
Sbjct: 1361 TPEAVTSIKKRGESLGYTEGALL 1383
Score = 275 bits (702), Expect = 6e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 380 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
Query: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 440 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 495
Query: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 496 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 555
Query: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 556 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 613
Query: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 614 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 671
Query: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 672 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 729
Query: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 786
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 846
Query: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 847 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 903
Query: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 904 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 963
Query: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 964 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 1021 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1074
Query: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 1075 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1124
Query: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 1125 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1184
Query: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 1185 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1244
Query: 2302 VSVLDDND 2309
VSV++ D
Sbjct: 1245 VSVVNQLD 1252
Score = 272 bits (696), Expect = 3e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 197
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 437 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 493
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 554 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 612
Query: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 613 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 670
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 671 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 723
Query: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 782
Query: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 843 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 899
Query: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 900 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1020 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1076
Query: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1077 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1134
Query: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1135 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Score = 257 bits (657), Expect = 1e-67
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 142 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 377
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 433
Query: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
+ + ++ YT Q + Y + + +Q G+
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 554 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 667
Query: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 668 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 726
Query: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 727 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 782
Query: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 783 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 842
Query: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 843 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902
Query: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 903 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962
Query: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 963 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1015
Query: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 1016 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1070
Query: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1071 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1130
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 1131 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1190
Query: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
P + + F+++ TG I + + + V A D K D
Sbjct: 1191 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1245
Query: 2408 SLVVWVDIEGI 2418
S+V +D++ I
Sbjct: 1246 SVVNQLDMQVI 1256
Score = 240 bits (612), Expect = 2e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 375
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 481
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 482 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 511
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 512 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 566
Query: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 567 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 626
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 627 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 682
Query: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 683 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 741 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 791
Query: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 792 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 848
Query: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 849 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 906
Query: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 907 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 966
Query: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 967 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1025
Query: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1026 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1082
Query: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1083 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1142
Query: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1202
Query: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
+ +G +KT+ RS F +A D
Sbjct: 1203 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 231 bits (590), Expect = 6e-60
Identities = 267/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 108 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 167 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 226
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 227 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 347 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 405
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 406 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 465
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 466 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 523
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 524 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 583
Query: 1548 HTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ + A D + R TV I+V + N + P Q + + +S +
Sbjct: 584 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 643 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 701
Query: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 702 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 761
Query: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 762 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 816
Query: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 817 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 874
Query: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 875 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 932
Query: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 933 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 992
Query: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 993 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1052
Query: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 1053 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1107
Query: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 1108 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1167
Query: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
++ D D T + + Y +I
Sbjct: 1168 VLRVKATDKD-TGNYSVMAYRLI 1189
Score = 215 bits (547), Expect = 6e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 461
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 462 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 519
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 520 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 578
Query: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 579 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 638
Query: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 639 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 695
Query: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 696 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 755
Query: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 756 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 812
Query: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 813 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 864
Query: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 865 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 919
Query: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 920 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 979
Query: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 980 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1038
Query: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
+F + L T+ + + A + YSIVS + D F I
Sbjct: 1039 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1087
Query: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 1088 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1147
Query: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1148 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1188
Score = 214 bits (544), Expect = 1e-54
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 50 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 109
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 110 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 168
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 169 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 227
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 228 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 347 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 404
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 464
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 465 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 522
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 523 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 582
Query: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 583 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 642
Query: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 643 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 699
Query: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 700 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 754
Query: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 755 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 801
Query: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 802 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 859
Query: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 860 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 919
Query: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 920 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 977
Query: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 978 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 1035 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1091
Query: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 1092 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1149
Query: 2536 ASSFSI 2541
F I
Sbjct: 1150 QKKFYI 1155
Score = 210 bits (535), Expect = 1e-53
Identities = 302/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
++ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 35 EDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 89
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 90 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 149 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 206 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 316
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 317 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 352
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 353 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 405
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 406 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 462
Query: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 463 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 520
Query: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 521 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 578
Query: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 579 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 637
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 638 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 692
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 693 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 747
Query: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 748 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 804
Query: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 805 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 862
Query: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 863 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 920
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 921 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 980
Query: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 981 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1040
Query: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1041 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1096
Query: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1097 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1156
Query: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1157 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1210
Score = 199 bits (505), Expect = 4e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 368 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 428 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 486
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 487 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 545
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 546 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 606 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 660
Query: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 717
Query: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 718 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 773
Query: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
G+IY V L+RE R +
Sbjct: 774 ---GSIYTA-----------------------------------------VKLNREVRDY 789
Query: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 790 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 845
Query: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 846 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 903
Query: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 904 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 961
Query: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 962 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1019
Query: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1020 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1073
Query: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1074 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1132
Query: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1133 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1192
Query: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1193 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1250
Query: 1263 ND 1264
D
Sbjct: 1251 LD 1252
Score = 188 bits (477), Expect = 8e-47
Identities = 255/1093 (23%), Positives = 455/1093 (41%), Gaps = 128/1093 (11%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 508 DSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
+ ++ + + + VF + + G+ L L + EQ+ T ++ A D GV
Sbjct: 439 EDTKDPELHLFL-NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 495
Query: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 496 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 552
Query: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVW 683
+ F I TG I + + +TY V A +N TV + V
Sbjct: 553 ILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 611
Query: 684 DENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFK 739
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F
Sbjct: 612 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFN 667
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
++ TG ++T LG+ ALDR
Sbjct: 668 LSETTG------ILT-------------------------------LGK-------ALDR 683
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E + + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 684 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEAN 738
Query: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVI 919
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+
Sbjct: 739 AFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 795
Query: 920 ATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
ATD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VD 852
Query: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSL 1035
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 853 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 911
Query: 1036 SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYY 1094
+++ V+D ND+ P F + V + GT + A+D D L SR++Y
Sbjct: 912 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 971
Query: 1095 IE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
++ + F + G ++T L+ E L V A D V S T +
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVK 1028
Query: 1153 IVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENM 1210
I++L + P F + V E T G++V I+A N + YSI+SGNE
Sbjct: 1029 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1083
Query: 1211 TFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVN 1263
TF ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N
Sbjct: 1084 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1143
Query: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEIN 1320
+ PVF++ Y V E+ V RV+A D+D+G S + + I+P E F +
Sbjct: 1144 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1203
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEF 1374
+ TG + T + + F +V+ D LS +L +V ++ D + P
Sbjct: 1204 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1263
Query: 1375 IVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELS 1431
+V D+ E+L+ E + G R + ++ T T+ + +
Sbjct: 1264 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ-- 1321
Query: 1432 TTRALDREQISNF 1444
T RA+DR ++ F
Sbjct: 1322 TNRAIDRNELFKF 1334
Score = 136 bits (342), Expect = 3e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 467 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 524
Query: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 525 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 583
Query: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 584 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 643
Query: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 644 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 700
Query: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 701 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 749
Query: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 750 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 803
Query: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 804 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 863
Query: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
FF ++P TG + + + AF E L F G
Sbjct: 864 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 909
Query: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
PP AT+ V V D+ND P F + + +
Sbjct: 910 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 943
Query: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 944 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 999
Query: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 1000 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 1060 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1114
Query: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1115 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1174
Query: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
D D G++ + I G F++ G + T
Sbjct: 1175 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1211
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 472 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 518
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 519 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 577
Query: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
++ ++ + ++ E + + +V + +F + + +
Sbjct: 578 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 636
Query: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 637 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 694
Query: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 695 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 745
Query: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 746 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 802
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 803 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 860
Query: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 861 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 920
Query: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 921 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 976
Query: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 977 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1034
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 1035 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1087
Query: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
N T G IYV + + ++VL+ V D
Sbjct: 1088 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1115
Query: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 1116 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1165
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 1166 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1225
Query: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 1226 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1279
Query: 977 QQ 978
Q
Sbjct: 1280 VQ 1281
Score = 112 bits (279), Expect = 7e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 535 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 588
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 589 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 639
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 640 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 696
Query: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 697 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 741
Query: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 742 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 796
Query: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 797 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 855
Query: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 856 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 915
Query: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 916 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 972
Query: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 973 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1032
Query: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 1033 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1083
Query: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 1084 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1142
Query: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1040 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1099
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1100 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1155
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1156 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1208
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 194
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 271 bits (693), Expect = 7e-72
Identities = 306/1155 (26%), Positives = 494/1155 (42%), Gaps = 137/1155 (11%)
Query: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 380 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
Query: 1507 ----EGL---NGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDC 1557
G+ + + FL D S FT+ T L +DRE + +TFS A D
Sbjct: 440 DVPPSGVPTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD- 497
Query: 1558 SIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGT 1617
+Q S VI+ + V D NDN P + +DV++ + + + + A D D G NG
Sbjct: 498 GVQ--ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 555
Query: 1618 VVFSF-AETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVI 1673
+ + Q F I+K TG I P E L ++ D PA + +
Sbjct: 556 ITYEILVGAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTV 613
Query: 1674 HME----GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
++E F +Y ++E G ++ ++A D DS+ Y+I +G+
Sbjct: 614 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQR 671
Query: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCF 1787
V +L +G LT+ K LD E + LI+ A + V +++ D NDN+P F
Sbjct: 672 VFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 729
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
+ + + + NA V QV ATD D+G+NG + YS+ GN F+I + +G I T
Sbjct: 730 DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTA 786
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
L+ E+ Y L+V ATD + +T + ++V DI+DN+P F S + E++LP
Sbjct: 787 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 846
Query: 1907 GVIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELL 1964
G + + DVDL + + +P K FA+ TG + L+++LD+E + E
Sbjct: 847 GTTILQIEAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 903
Query: 1965 IQISDSVHYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT 2017
I G + V V D+ND PPVFS+ Y+ V G + T+ A
Sbjct: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
Query: 2018 DLESN----ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEA 2066
D + + YR+ + F ++ +G + T + L+ TT F +V A
Sbjct: 964 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVA 1020
Query: 2067 SDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTR 2125
D G P + + V+I + P FT + Y +SE A G+ + S
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AA 1074
Query: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------EL 2178
N + YSI+SGN ++ F + G + + LD E S+ L
Sbjct: 1075 INQSIVYSIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSL 1124
Query: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD 2238
++ ++ P S+TA + I++ D N++PP F Y V E + + + V A D+D
Sbjct: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
Query: 2239 TGSHAEIIYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF 2295
TG+++ + Y +I K F +E TG++ + + F V A+D K
Sbjct: 1185 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1244
Query: 2296 S-FAVVFVSVLDDND 2309
S A V VSV++ D
Sbjct: 1245 SGKADVLVSVVNQLD 1259
Score = 271 bits (693), Expect = 7e-72
Identities = 285/1082 (26%), Positives = 476/1082 (43%), Gaps = 119/1082 (10%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 197
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1297 D------SGVNSK-LQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLV 1346
D SGV +K + + +F + + TG T+L DRE Q+ +T +
Sbjct: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITA 495
Query: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNN 1405
DG S + V D ND+ P F SYD+ V + P + V + A D D G+N
Sbjct: 496 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
Query: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIH 1463
+ Y I+ G + F IN+ +G ++ ++ + L + +D P R+S+
Sbjct: 554 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
Query: 1464 LQVRVLDANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS 1522
+ + VL N+ S P FP L Y + E VG V+L L A D++ + T +
Sbjct: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQ 670
Query: 1523 GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPV 1582
F + +G L LDRE+ ++ A D G+ + TV + VTDVNDN PV
Sbjct: 671 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV 728
Query: 1583 LEQNPFDVFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE 1637
FD +L E N V+A D D G NG V +S ++F I G
Sbjct: 729 -----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGS 782
Query: 1638 IQFQQNPSSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTE 1695
I + E + + V G P +T L + ++ +D F++ Y LV E
Sbjct: 783 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 842
Query: 1696 NCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--R 1753
N AGT+I+ ++A D + ++ Y I S +L +G+L++ + LD+E
Sbjct: 843 NLPAGTTILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPD 899
Query: 1754 NEVQLIVLAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
E + L E+ + V V+++D ND P F + IY+ V+ + +
Sbjct: 900 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 959
Query: 1809 VFATDLD-SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQ 1863
V+A D D GL + Y + F+++ SG + T+ L+ E T+ + L+V
Sbjct: 960 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1019
Query: 1864 ATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLN 1921
A D G P +S++ +K+ V + P F E ++E + G +V +S +N
Sbjct: 1020 AFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAIN 1076
Query: 1922 SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-------- 1973
+ ++S + T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1077 QSIVYSIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVP 1134
Query: 1974 ---TEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYR 2028
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR
Sbjct: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1194
Query: 2029 IL 2030
++
Sbjct: 1195 LI 1196
Score = 259 bits (661), Expect = 4e-68
Identities = 281/1157 (24%), Positives = 495/1157 (42%), Gaps = 137/1157 (11%)
Query: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 142 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 377
Query: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT------------VIVRAD 1608
+ + + D N+ P + ++ +P T V + D
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 1609 DLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-------- 1660
D+ P+G + + ++ YT Q + Y + + +Q
Sbjct: 438 IEDVPPSGVPT---KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
Query: 1661 ---GIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQD 1716
G+ + + M+ D +F Y V + G S++ + A A +
Sbjct: 495 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
Query: 1717 SMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYC 1771
+ Y I G + G + +G +T+ ++ V L V A + + C
Sbjct: 555 EITYEILVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSIC 611
Query: 1772 KVAVLIQDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGN 1830
V + + N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+
Sbjct: 612 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGD 668
Query: 1831 QEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAP 1890
+ F + +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP
Sbjct: 669 PQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP 727
Query: 1891 AF---LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVV 1947
F LP + E++ V + D +N +S +N F I N +
Sbjct: 728 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIY 784
Query: 1948 VLVKTLDFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPES 2004
VK L+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E+
Sbjct: 785 TAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 843
Query: 2005 IPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTIST 2059
+P G ++L + A D++ N+SYRI S + F++ P G + + + D ++
Sbjct: 844 LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 903
Query: 2060 TQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNI 2119
FLVEA D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T
Sbjct: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
Query: 2120 DHDWTR-ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHEL 2178
D D + V Y + F F E + G ++ +L+ E + +L
Sbjct: 964 DADPPGLPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKL 1016
Query: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDR 2237
V++A D G P +SS+A + I VL + P F+ Y V E G+ + V+SA
Sbjct: 1017 VVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA--- 1072
Query: 2238 DTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE------ 2291
+ I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 1073 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1131
Query: 2292 --KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y +
Sbjct: 1132 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1191
Query: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD-------- 2401
Y ++ P + + F+++ TG I + + + V A D
Sbjct: 1192 AYRLIIP-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1246
Query: 2402 KGDATASLVVWVDIEGI 2418
K D S+V +D++ I
Sbjct: 1247 KADVLVSVVNQLDMQVI 1263
Score = 243 bits (621), Expect = 2e-63
Identities = 294/1167 (25%), Positives = 477/1167 (40%), Gaps = 140/1167 (11%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM--TQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P+ T +Q Q
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE-QD 375
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKN 724
+G + + + DEN+ SP F P QG I + A DS
Sbjct: 376 NGHPLPAFAGLHIEILDENNQSPYFT----------MPSYQGYILESAPVGATISDSLNL 425
Query: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV--LKSL 782
L + D + P+ P EL F+ S+
Sbjct: 426 TSPLRIVALDKDIEDVPPSGVPT----------------------KDPELHLFLNDYTSV 463
Query: 783 FCELGEGELINWVAL----DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838
F G + ++ L DRE + + ++ D + + V + V D NDN P
Sbjct: 464 FTVTQTG-ITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPT 520
Query: 839 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG 898
FP+ ++ + G V L A D DEG+N E+TY + D F I+ G
Sbjct: 521 FPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKTTG 575
Query: 899 EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVIPLS-KGRAIMSQNIRHL 955
I + +Y ++V A D P + ++ V I+V+P + + Q + L
Sbjct: 576 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
Query: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
I E ++ ++ ++++D + ++I D F + +TG L L K LD E
Sbjct: 636 EISEAMRVGAVLLNLQATDR----EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
Query: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVPIG 1071
+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N +G
Sbjct: 692 STDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 749
Query: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
+ A D D +N ++ Y + + N N F I S G++ T +L+RE L
Sbjct: 750 QV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYELV 800
Query: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHD 1190
V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A D
Sbjct: 801 VVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 857
Query: 1191 PDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDDGT 1246
D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 858 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 915
Query: 1247 PALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------SGV 1300
T+TV V D+ND PVF + +Y+ V + G +T V A D D S V
Sbjct: 916 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 975
Query: 1301 NSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+ T+
Sbjct: 976 RYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 1034
Query: 1361 LCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
V + P F Y + E T++ A N+++ Y I+ GN ++
Sbjct: 1035 KILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1091
Query: 1421 FTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDAND 1473
F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D N+
Sbjct: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
Query: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTIDP 1529
H P F +Y V EDA + T VL + A DKD G Y L E F ++
Sbjct: 1152 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
Query: 1530 MSGTLKTSNTLDREARSQHTFSAVARD 1556
+G +KT+ RS F +A D
Sbjct: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATD 1238
Score = 224 bits (572), Expect = 7e-58
Identities = 267/1110 (24%), Positives = 478/1110 (43%), Gaps = 115/1110 (10%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 108 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 167 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 226
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 227 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 347 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 405
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGN-------NRAVEYHIIDGNTDECFT 1422
+LE+ + ++A D D + + E H+ + FT
Sbjct: 406 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFT 465
Query: 1423 INE--MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
+ + ++ L+ + +DRE+ +T I D S + + ++V+DAND++P+FP
Sbjct: 466 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPE 523
Query: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
+ Y V D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + +
Sbjct: 524 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 583
Query: 1541 DREARSQHTFSAVARDCSIQGSRST---TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESP 1597
+ + + A D + R TV I+V + N + P Q + + +S
Sbjct: 584 EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMR 642
Query: 1598 TNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKV 1657
+ ++A D + G + T + Q +F++ + TG + + E ++ +
Sbjct: 643 VGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 701
Query: 1658 TDQGIPARTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQ 1715
G P T+T + ++ + D F +L + L EA + VKA PD+ I
Sbjct: 702 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 761
Query: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCK 1772
+ YS+ GN + + + S T + L+ EVR+ +L+V+A +
Sbjct: 762 GQVHYSL--GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLT 816
Query: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
+A+ + D +DNSP F S Y V E+ ++Q+ A D+D G N + Y I S +
Sbjct: 817 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 874
Query: 1833 EAFQIDALSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDN 1888
F + +G ++ LDYE +S + +V+A D + V V D+ND
Sbjct: 875 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 934
Query: 1889 APAFLPSEAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFA 1939
P F S+ + + D++ G +T V D D + + P + F
Sbjct: 935 PPVF--SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 992
Query: 1940 IDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDF 1996
+++++G V+ L+ E T ++L++ D V + + + VL + P +++
Sbjct: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1052
Query: 1997 YQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLL 2054
V E G V +SA + N++I Y I+S ++E F I+ G I+ P L
Sbjct: 1053 RPPPVSELATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---L 1107
Query: 2055 DTISTTQFLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
D + T +++ P V I I+D NN+ P F K Y +SE
Sbjct: 1108 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1167
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
DA + ++++ D D T + + Y +I
Sbjct: 1168 DARMFTSVLRVKATDKD-TGNYSVMAYRLI 1196
Score = 212 bits (539), Expect = 5e-54
Identities = 296/1126 (26%), Positives = 480/1126 (42%), Gaps = 125/1126 (11%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKS 1737
Y+G + E+ G TS + + A D I+D + + + + L L +
Sbjct: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDVPPSGVPTKDPELHLFLNDYT 461
Query: 1738 GQLTVKEPKFLDFEV------RNEVQLIVLAESS--GHRAYCKVAVLIQ--DENDNSPCF 1787
TV + + R E Q + ++ G + V V IQ D NDN+P F
Sbjct: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTF 521
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
+ Y V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT
Sbjct: 522 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 580
Query: 1848 AILDYELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITED 1903
++ + +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E
Sbjct: 581 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 640
Query: 1904 SLPGVIVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYE 1962
G ++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y
Sbjct: 641 MRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 697
Query: 1963 LLIQISDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
L+I SD V ++ DVNDN PVF + V + ATD +
Sbjct: 698 LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 757
Query: 2021 S--NENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRAL 2077
+ N + Y + + + F I NG+I+T + L + + +V A+DG +P L
Sbjct: 758 AGINGQVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTL 815
Query: 2078 TLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG 2137
TL I + D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 816 TLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP 871
Query: 2138 NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSST 2193
E K F + +P+ G L LL SLD EA AS ++ A D
Sbjct: 872 --------EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 921
Query: 2194 AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISG 2252
A +++ V D+ND PP FS Y V G+ IT V A D D G A + +
Sbjct: 922 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 981
Query: 2253 NEKGH----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDD 2307
+ + F +EE++G + L+ E T F L V A D E S A V + VL
Sbjct: 982 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1041
Query: 2308 NDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDH 2367
+ P+F + L T+ + + A + YSIVS +
Sbjct: 1042 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEE 1089
Query: 2368 DLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGI 2418
D F I+ +TG I+ LDYE Y L VQA A+L V+++I+
Sbjct: 1090 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1149
Query: 2419 DEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
+ P+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 1150 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
Score = 210 bits (534), Expect = 2e-53
Identities = 296/1153 (25%), Positives = 482/1153 (41%), Gaps = 137/1153 (11%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 50 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 109
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 110 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 168
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 169 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 227
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 228 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 347 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 404
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLD------SGLNGLI-EYSILSGNQEEAF 1835
YQ + ES A + +++ A D D SG+ E + + F
Sbjct: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVF 464
Query: 1836 QID--ALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL 1893
+ ++ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F
Sbjct: 465 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFP 522
Query: 1894 P-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKT 1952
S V + D PG V ++ D D S ++ F I++ TG++ +
Sbjct: 523 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 582
Query: 1953 LDFEEMTEYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIP 2006
++ Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++
Sbjct: 583 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 642
Query: 2007 VGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLV 2064
VG +L L ATD E ++I+Y I + + F++ G I T+ L ++ ++
Sbjct: 643 VGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILII 700
Query: 2065 EASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNID 2120
ASDG PD + V I + D+N+ AP F NLS+ E+ A VG T D
Sbjct: 701 TASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----D 755
Query: 2121 HDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVI 2180
D N V YS+ GN N F + + G + L+RE +ELV+
Sbjct: 756 PD-AGINGQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVV 801
Query: 2181 LASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTG 2240
+A+D P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G
Sbjct: 802 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 861
Query: 2241 SHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHF 2295
A + Y I S K F L TG L L++ LDYE + T V+A D
Sbjct: 862 --ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 919
Query: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSI 2353
A V V V D ND+ P F + +V + + I ++ A D D P + Y +
Sbjct: 920 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 979
Query: 2354 VSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWV 2413
F Y +F ++ +G + + L+ E + L V A D G+ S V
Sbjct: 980 DDVQF-----PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 1034
Query: 2414 DIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPF 2470
I + E P FTQ++Y P + G + + A I+ I+YS+ G
Sbjct: 1035 KILVLHPGEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1091
Query: 2471 FSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSE 2528
F +N G IY+ L S + + ++++ + + SK + V++ + +
Sbjct: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
Query: 2529 GTPLAVFASSFSI 2541
P VF F I
Sbjct: 1152 HPP--VFQKKFYI 1162
Score = 204 bits (519), Expect = 1e-51
Identities = 303/1262 (24%), Positives = 517/1262 (40%), Gaps = 186/1262 (14%)
Query: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
++ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 35 EDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 89
Query: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 90 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
Query: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 149 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
Query: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 206 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 261
Query: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
D +D P FL VL L+ E P V I AID D
Sbjct: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 316
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
+ P + G +Y I GT D + F + EL
Sbjct: 317 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 352
Query: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 353 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 405
Query: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKID--- 894
+ + +LE PV ++ + A D D + V ++D H ++
Sbjct: 406 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIED--VPPSGVPTKDPELHLFLNDYT 461
Query: 895 -----ANNGEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRA 946
G R T+L + + +Y S+ A D GV + +VNIQV+ +
Sbjct: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTP 519
Query: 947 IMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDL 1006
+ + + +++P + + + D + NG++ + I+ G F I+ +TG +
Sbjct: 520 TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLI 577
Query: 1007 FLSKELDYETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVIS 1063
++ ++ Y V D+ ++ + TV++ + + N P F + +
Sbjct: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLE 636
Query: 1064 VEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRE 1123
+ E + +G ++ A D +G I Y IE+ +P F + + G L LDRE
Sbjct: 637 ISEAMRVGAVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRE 691
Query: 1124 SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGS 1181
S IL +TASD + T + T IV+ DVND+ P F + N V E+ +
Sbjct: 692 STDRYILIITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANA 746
Query: 1182 LVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
V + A DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A
Sbjct: 747 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 803
Query: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
D S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N
Sbjct: 804 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 863
Query: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLS 1355
+ + I F ++ TGE+ L D+E F + G P
Sbjct: 864 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 921
Query: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHI 1412
+T T++ V+D ND+ P F Y V + + + TV A D D A V Y +
Sbjct: 922 ATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 979
Query: 1413 IDGN---TDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL 1469
D F + E SG + T L+ E + F LV++ D G+P SS +++ VL
Sbjct: 980 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1039
Query: 1470 DANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTID 1528
+ Y V E A GT+V V+SA +N Y ++ F I+
Sbjct: 1040 HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095
Query: 1529 PMSGTLKTSNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPV 1582
++G + + LD E R+ + A + S+S T + + + D N++ PV
Sbjct: 1096 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
Query: 1583 LEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGE 1637
++ + +S ++ + + V+A D D G + + E + F ++ YTG
Sbjct: 1156 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1215
Query: 1638 IQ 1639
I+
Sbjct: 1216 IK 1217
Score = 184 bits (468), Expect = 8e-46
Identities = 258/1099 (23%), Positives = 449/1099 (40%), Gaps = 133/1099 (12%)
Query: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
Query: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
P + ++I ++D N+ P F S + I ++ P G + + L +
Sbjct: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
Query: 519 IASPQPGVFAIDRALGVLFLNG--------------------SLGAGEQRELTLTLRAED 558
P GV D L LFLN + EQ+ T ++ A D
Sbjct: 439 EDVPPSGVPTKDPELH-LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 497
Query: 559 QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 618
GV ++V V++ +++P TF + Y V V + P ++Q A + +
Sbjct: 498 -GVQESEPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSN 553
Query: 619 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTT 677
+ Y + F I TG I + + +TY V A +N T
Sbjct: 554 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
Query: 678 VIVRVWDENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG- 735
V + V N+ SP +++ L++ E+ V+ + A D + G + + + +G
Sbjct: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGD 668
Query: 736 --KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELIN 793
+ F ++ TG ++T LG+
Sbjct: 669 PQRVFNLSETTG------ILT-------------------------------LGK----- 686
Query: 794 WVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVL 853
ALDRE + + + +D G P +T V + VTD+NDN P F LP ++ V+
Sbjct: 687 --ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVV 740
Query: 854 EGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS 913
E + N V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R
Sbjct: 741 E-EEANAFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDY 796
Query: 914 YRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSS 973
Y + V+ATD V P + I+V+ + + + + +++ ENL + I++
Sbjct: 797 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 856
Query: 974 DHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDH 1029
D + + I + + F + TG+L L + LDYE + F V D
Sbjct: 857 D---VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 913
Query: 1030 SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-N 1088
+ +++ V+D ND+ P F + V + GT + A+D D L
Sbjct: 914 YGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 972
Query: 1089 SRIQYYIE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL 1146
SR++Y ++ + F + G ++T L+ E L V A D V
Sbjct: 973 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS--- 1029
Query: 1147 RSLTAQIVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL 1204
S T +I++L + P F + V E T G++V I+A N + YSI+
Sbjct: 1030 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1084
Query: 1205 SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTV 1257
SGNE TF ++ +G++ PLDYE +T ++L V A + P+ S++ + +
Sbjct: 1085 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1144
Query: 1258 TVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASF 1314
+ D N+ PVF++ Y V E+ V RV+A D+D+G S + + I+P
Sbjct: 1145 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1204
Query: 1315 ELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND----- 1369
E F + + TG + T + + F +V+ D LS +L +V ++ D
Sbjct: 1205 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIV 1264
Query: 1370 -HAPEFIVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
+ P +V D+ E+L+ E + G R + ++ T T+
Sbjct: 1265 SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYA 1324
Query: 1426 MSGELSTTRALDREQISNF 1444
+ + T RA+DR ++ F
Sbjct: 1325 IDPQ--TNRAIDRNELFKF 1341
Score = 122 bits (305), Expect = 7e-27
Identities = 248/1114 (22%), Positives = 421/1114 (37%), Gaps = 150/1114 (13%)
Query: 106 PQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRV 165
P+ F + P ++ + + ++R+ +DL+++A EQ H L A A + +
Sbjct: 340 PRFFHMHPRTAELSLLEPVNRDFHQK-FDLVIKA----EQDNGH------PLPAFAGLHI 388
Query: 166 DLEDVNDNHPVFNPSTYVTSISDETQPGTEI---------INVLATDQD------SGI-Y 209
++ D N+ P F +Y I + G I + ++A D+D SG+
Sbjct: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
Query: 210 GTVAYELIPGNVSSLFTIDST------TGLYSPEVEILSAVNFSADKEVMNSLEMFLPLL 263
L + +S+FT+ T T L + E FS + ++ P++
Sbjct: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT--AFDGVQESEPVI 506
Query: 264 RHFKKVE-RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE--------AAA 314
+ + ++ D + + + + L D ++GE A
Sbjct: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 566
Query: 315 RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAP 374
++ N G+I + + + T +L V A D N+ T++I L P
Sbjct: 567 DFIINKTT----GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI--EVLPP 620
Query: 375 AEFERPKYTFLVYE-DVPEDSPIGTVKAREPLNSSE--PIFYRISSGDLGGKFSIHPRLG 431
P++ L+Y ++ E +G V E I Y I +GD F++ G
Sbjct: 621 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTG 680
Query: 432 TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQ 491
+ K LD E+ +L + A G S+ VNI V DVNDN P F
Sbjct: 681 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
Query: 492 TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELT 551
+ +A D D+G NG + YS+ + +F I + G ++ L +
Sbjct: 741 EEEANAFVGQVKATDPDAGINGQVHYSLGNFN-NLFRI-TSNGSIYTAVKLNREVRDYYE 798
Query: 552 LTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
L + A D VHP+ + L L + V++ ++SP F + Y V V E+L T +LQ +A
Sbjct: 799 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSP--VFTNSTYTVLVEENLPAGTTILQIEAK 856
Query: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES----TQTYNFRVFAWIP 666
+ + + Y + F + P+TG + L R DYE+ + F V A+
Sbjct: 857 DVD---LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF-D 912
Query: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQ 726
G + TV V V D ND P F + V V I + A D D
Sbjct: 913 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD------ 966
Query: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLF-CE 785
P PA + + D++Q S+F E
Sbjct: 967 ---------------PPGLPASRV-----------------RYRVDDVQFPYPASIFEVE 994
Query: 786 LGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 845
G +I V L+ E ++ V+ D G P +++ V + V + P F Q
Sbjct: 995 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ---- 1049
Query: 846 KELHVKVLEGQPVNMLVT--TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTT 903
+ PV+ L T T+ N + YS+ S + D F I+ G I
Sbjct: 1050 -----EEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1104
Query: 904 TILSYDYRPSY-------RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI 956
L Y+ R SY + V+ + VP A V I++ + + +
Sbjct: 1105 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1164
Query: 957 IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH--FEIDSSTGDLFLSKELDY 1014
+ E+ + + +K++D +Y+ + I+ K+G F +++ TG + +
Sbjct: 1165 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1224
Query: 1015 ETTSHYLFRVITT-DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTL 1073
S++ F+VI T D+ K LS + V +S+ ++L + + NVP TL
Sbjct: 1225 MRRSYFKFQVIATDDYGKGLSGKADVLVSV------------VNQLDMQVIVSNVP-PTL 1271
Query: 1074 VYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVT 1133
V K +D L + Y++ PG ++ S G E LTV
Sbjct: 1272 V---EKKIED---LTEILDRYVQEQIPGAK--VVVESIGARRHGDAFSLEDYTKCDLTVY 1323
Query: 1134 ASDQAVN-VTDRRLRSLTAQIVILDVN-DHNPTF 1165
A D N DR +LD+N D P +
Sbjct: 1324 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYY 1357
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 750 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 800
Query: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 801 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 849
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 850 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 903
Query: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
+ + P + + +D F +KG +K
Sbjct: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 958
Query: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 959 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1018
Query: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 1019 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 1072
Query: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 1073 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
Query: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
Query: 514 LIRYSIASP 522
++ Y + P
Sbjct: 1190 VMAYRLIIP 1198
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 1047 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1106
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1107 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1162
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1163 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1215
Score = 54.3 bits (129), Expect = 2e-06
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 18/144 (12%)
Query: 92 IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLA 151
I Y++ +G + + F + G + + + +DRE Y L++ A DG
Sbjct: 660 ITYAIENG----DPQRVFNLSETTGILTLGKALDRESTDR-YILIITASDGRPDG----- 709
Query: 152 LVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 211
++ A V + + DVNDN PVF+P E + + V ATD D+GI G
Sbjct: 710 ------TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 763
Query: 212 VAYELIPGNVSSLFTIDSTTGLYS 235
V Y L GN ++LF I S +Y+
Sbjct: 764 VHYSL--GNFNNLFRITSNGSIYT 785
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 194
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 264 bits (674), Expect = 1e-69
Identities = 285/1108 (25%), Positives = 481/1108 (43%), Gaps = 145/1108 (13%)
Query: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
+PE +P T I D D ++ P +++S +
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ--------------------- 1831
V VIQ+ A D D G NG I Y IL G Q
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
Query: 1832 ------------EEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIK 1879
+ A + +G++T LD E T Y LI+ A+D G P ++T +
Sbjct: 575 VGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 633
Query: 1880 VQVTDINDNAPAF---LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGT 1936
+ VTD+NDNAP F LP + E++ V + D +N +S +N
Sbjct: 634 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--- 690
Query: 1937 KFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFS 1993
F I N + VK L+ E YEL++ +D +VH ++ L ++VLD++DN PVF+
Sbjct: 691 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 749
Query: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV 2051
Y V V E++P G ++L + A D++ N+SYRI S + F++ P G + + +
Sbjct: 750 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 809
Query: 2052 ---LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
D ++ FLVEA D + V + ++DMN+Y P F+ + Y ++ DA+
Sbjct: 810 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 869
Query: 2109 VGSTLVTFSNIDHDWT-RENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
G+ + T D D + V Y + F F E + G ++ +
Sbjct: 870 KGTPITTVYAEDADPPGLPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVN 922
Query: 2168 LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH-THVKESTPLG 2226
L+ E + +LV++A D G P +SS+A + I VL + P F+ Y V E G
Sbjct: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKG 981
Query: 2227 SHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
+ + V+SA + I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQ
Sbjct: 982 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
Query: 2287 ASDAE--------KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINA 2338
A E + A V++ + D+N+H P F + V E+ + +++ + A
Sbjct: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
Query: 2339 LDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQ 2398
D D G Y + Y ++ P + + F+++ TG I + + + V
Sbjct: 1098 TDKDTGNYSVMAYRLIIP-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152
Query: 2399 AKD--------KGDATASLVVWVDIEGI 2418
A D K D S+V +D++ I
Sbjct: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVI 1180
Score = 258 bits (660), Expect = 5e-68
Identities = 279/1059 (26%), Positives = 448/1059 (42%), Gaps = 158/1059 (14%)
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
Query: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
+ +LD +D P F+ + P E++ + I A D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1413 IDGNTDECFTINE----------------------------------MSGELSTTRALDR 1438
+ G + F IN+ +G L+ +ALDR
Sbjct: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
Query: 1439 EQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSF-PTLYYQSSVREDAEVGTVV 1497
E + L+I SD G P +S + + V D ND++P F P L SV E+ E V
Sbjct: 608 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFV 665
Query: 1498 LVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC 1557
+ A D D G+NGQ Y L + F I +G++ T+ L+RE R + VA D
Sbjct: 666 GQVKATDPDAGINGQVHYSL-GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDG 723
Query: 1558 SIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGT 1617
++ R +T+ + + V D++DN PV + + V + P T + + A D+DLG N +
Sbjct: 724 AVH-PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS 782
Query: 1618 VVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFP-----IWLQLKVTD-QGIPARTTTGLL 1671
E + F++ +TGE+ ++ E FP I ++ D G +
Sbjct: 783 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 842
Query: 1672 VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA--------------FAPDSIQDS 1717
VI + D FS +YKG+V + GT I TV A + D +Q
Sbjct: 843 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 902
Query: 1718 MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH-----RAYCK 1772
SIF ED SG++ + L+ E +L+V+A G A K
Sbjct: 903 YPASIFEVEED--------SGRVITRVN--LNEEPTTIFKLVVVAFDDGEPVMSSSATVK 952
Query: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
+ VL E P F Q Y+ ++ V + + +N I YSI+SGN+E
Sbjct: 953 ILVLHPGE---IPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEE 1006
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQA-------TDKGMPRLSNTTVIKVQVTDI 1885
+ F I+ ++GVI LDYE +SY L VQA + +P SNT + +++ D
Sbjct: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
Query: 1886 NDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSF------AKESNPGTKF 1938
N++ P F + ++ED+ V V D D + + ++ KE G F
Sbjct: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--F 1124
Query: 1939 AIDQNTGVVVLVKT-LDFEEMTEYELLIQISDSVHYTEG 1976
++ TG L+KT + F M Q+ + Y +G
Sbjct: 1125 VVETYTG---LIKTAMLFHNMRRSYFKFQVIATDDYGKG 1160
Score = 242 bits (617), Expect = 4e-63
Identities = 265/1031 (25%), Positives = 452/1031 (43%), Gaps = 140/1031 (13%)
Query: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
Query: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
Query: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
Query: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
Query: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
Query: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEY---------FLTDEASGAFTIDP--------- 1529
D G V+ L+AVD DEG NG+ Y F+ ++ +G TI P
Sbjct: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
Query: 1530 ----------------MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
+G L LDRE+ ++ A D G+ + TV + V
Sbjct: 579 YALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVV 636
Query: 1574 TDVNDNDPVLEQNPFDVFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM 1628
TDVNDN PV FD +L E N V+A D D G NG V +S ++
Sbjct: 637 TDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL 691
Query: 1629 FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSH 1686
F I G I + E + + V G P +T L + ++ +D F++
Sbjct: 692 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 750
Query: 1687 HLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPK 1746
Y LV EN AGT+I+ ++A D + ++ Y I S +L +G+L++ +
Sbjct: 751 STYTVLVEENLPAGTTILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--R 807
Query: 1747 FLDFEV--RNEVQLIVLAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSES 1799
LD+E E + L E+ + V V+++D ND P F + IY+ V+
Sbjct: 808 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 867
Query: 1800 QLYNAHVIQVFATDLD-SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYEL 1854
+ + V+A D D GL + Y + F+++ SG + T+ L+ E
Sbjct: 868 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 927
Query: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTH 1912
T+ + L+V A D G P +S++ +K+ V + P F E ++E + G +V
Sbjct: 928 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 986
Query: 1913 VSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH 1972
+S +N + ++S + T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 987 ISA--AAINQSIVYSIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1042
Query: 1973 Y-----------TEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES 2021
+ + + D N++PPVF + FY V E + SVL + ATD ++
Sbjct: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
Query: 2022 NEN--ISYRIL 2030
++YR++
Sbjct: 1103 GNYSVMAYRLI 1113
Score = 236 bits (602), Expect = 2e-61
Identities = 288/1128 (25%), Positives = 481/1128 (42%), Gaps = 124/1128 (10%)
Query: 392 EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRL-GTIRTRKPLDHETQPVVVLT 450
+D P G ++ N +P +S D F I L G I RK L++E + +
Sbjct: 180 DDGPNGQIEYVIQYNPDDP-----TSNDT---FEIPLMLTGNIVLRKRLNYEDKTRYFVI 231
Query: 451 VQA----QLGSAPACSSTEVNITVMDVNDNHPAFL-----------------------RT 483
+QA Q + ++T + + V+D +D P FL RT
Sbjct: 232 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 291
Query: 484 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI--ASPQ--PGVFAIDRALGVLFLN 539
+E+ TPP A+ R S R G++ YSI +P+ P F + L L
Sbjct: 292 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 540 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESL 598
+ ++ L ++AE HP A L + ++++ SP +T YQ + ES
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS--YQGYILES- 407
Query: 599 SPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM-FGIRPYTG-----------WIYLR 646
+P+ + + P R + L +E + D + + YT ++ L
Sbjct: 408 APVGATISDSLNLTSPLRIVA-LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
Query: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
+ D E QTY F + A+ DG ++ V ++V D NDN+PTF + V
Sbjct: 467 QPVDREEQQTYTFSITAF---DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 707 PQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGPAGTIYVITWADGAAAFSG 764
P + ++TA+D D G NG++ Y +L + G F +N TG +IT A G G
Sbjct: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTG------LITIAPGVEMIVG 576
Query: 765 TDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA 824
+A + + E G L ALDRE + + + +D G P +T
Sbjct: 577 RTYALTVQAAD----NAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT 631
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 884
V + VTD+NDN P F LP ++ V+E + N V V A DPD G N +V YS+
Sbjct: 632 VNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLG- 686
Query: 885 EDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKG 944
+ ++ F+I +NG I T L+ + R Y + V+ATD V P + I+V+ +
Sbjct: 687 -NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 744
Query: 945 RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTG 1004
+ + + +++ ENL + I++ D + + I + + F + TG
Sbjct: 745 SPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTG 801
Query: 1005 DLFLSKELDYET----TSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
+L L + LDYE + F V D + +++ V+D ND+ P F +
Sbjct: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 860
Query: 1061 VISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYYIE--SHNPGTNPFLIHPSFGTLVTV 1117
V + GT + A+D D L SR++Y ++ + F + G ++T
Sbjct: 861 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 920
Query: 1118 SRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI--SFPNAHVKE 1175
L+ E L V A D V S T +I++L + P F + V E
Sbjct: 921 VNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEEYRPPPVSE 976
Query: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235
T G++V I+A N + YSI+SGNE TF ++ +G++ PLDYE +T +
Sbjct: 977 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1032
Query: 1236 ILTVLA-------LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFV 1288
+L V A + P+ S++ + + + D N+ PVF++ Y V E+ V
Sbjct: 1033 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1092
Query: 1289 TRVEALDRDSGVNSKLQFE-IMP--GASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
RV+A D+D+G S + + I+P E F + + TG + T + + F +V+
Sbjct: 1093 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152
Query: 1346 VRDGGFPSLSSTTTILCTVEDEND------HAPEFIVSS--YDI-EVLENQEPEVVYTVL 1396
D LS +L +V ++ D + P +V D+ E+L+ E +
Sbjct: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAK 1212
Query: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNF 1444
G R + ++ T T+ + + T RA+DR ++ F
Sbjct: 1213 VVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ--TNRAIDRNELFKF 1258
Score = 188 bits (478), Expect = 6e-47
Identities = 266/1135 (23%), Positives = 437/1135 (38%), Gaps = 173/1135 (15%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
+ D L L G++ E+R T TL
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
Query: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
Query: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
+ T +T + + V + V D NDN
Sbjct: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
Query: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
Query: 897 NGEIR-------------TTTILSYDYRPSYRMS--------------------VIATDQ 923
G I T+ + D P S +I
Sbjct: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
Query: 924 GVPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
G P A VNI V ++ + + R+L + E + + +K++D NG
Sbjct: 622 GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDP-DAGING 679
Query: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
++H+S+ + + F I +S G ++ + +L+ E +Y V+ TD + + ST+ L+
Sbjct: 680 QVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH-PRHSTLTLA 735
Query: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
I V D +D+SP F + + VEEN+P GT + AKD D L + + Y I S
Sbjct: 736 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD---LGANVSYRIRSPEV-K 791
Query: 1103 NPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSL-TAQIVILDVNDH 1161
+ F +HP G L + LD E+ P ++T +A ++ + T +++ D+ND+
Sbjct: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
Query: 1162 NPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEG--RNGKVTY---SILSGNENMTFMLD 1215
P F V D G+ + + A D D +V Y + F ++
Sbjct: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 911
Query: 1216 ESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYE 1275
E SG + T L+ E T L V+A DDG P +SSS T+ + VL E P F Q Y
Sbjct: 912 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYR 970
Query: 1276 -ASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDR 1334
V E G V + A + +N + + I+ G + F IN+ TG + LD
Sbjct: 971 PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1026
Query: 1335 EIQEVFTLR-------VLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
E + + LR V++ + PS S+T + ++DEN+H P F Y V E+
Sbjct: 1027 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1086
Query: 1388 EP-EVVYTVLASDMDAGNNRAVEYHII-----DGNTDECFTINEMSGELSTTRALDREQI 1441
V V A+D D GN + Y +I +G E F + +G + T +
Sbjct: 1087 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRR 1144
Query: 1442 SNFTLVILCSD---LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEV 1493
S F ++ +D G ++ V+ V LD + P + + + E+
Sbjct: 1145 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEI 1199
Score = 169 bits (428), Expect = 4e-41
Identities = 278/1103 (25%), Positives = 441/1103 (39%), Gaps = 159/1103 (14%)
Query: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
Query: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
Query: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
Query: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Query: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
Query: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
YQ + ES A + +++ A D D E + + F + +
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
Query: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSF-----------------------AKESNPGT 1936
+ D PG V ++ D D S ++ E G
Sbjct: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
Query: 1937 KFAI-----------DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVL-- 1983
+A+ +++TG++ L K LD E Y L+I SD V ++
Sbjct: 578 TYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 637
Query: 1984 DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPK 2041
DVNDN PVF + V + ATD ++ N + Y + + + F I
Sbjct: 638 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-S 696
Query: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
NG+I+T + L + + +V A+DG +P LTL I + D+++ +P FT +Y
Sbjct: 697 NGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYT 754
Query: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
+ + E+ G+T++ D D V Y I S E K F + +P+ G
Sbjct: 755 VLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP--------EVKHFFALHPF--TG 801
Query: 2161 YLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
L LL SLD EA AS ++ A D A +++ V D+ND PP FS Y
Sbjct: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
Query: 2217 THVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH----FYLEENTGVLYLIK 2271
V G+ IT V A D D G A + + + + F +EE++G +
Sbjct: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 921
Query: 2272 PLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPIS 2330
L+ E T F L V A D E S A V + VL + P+F + L
Sbjct: 922 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATK 980
Query: 2331 STICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG 2390
T+ + + A + YSIVS + D F I+ +TG I+ LDYE
Sbjct: 981 GTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGINNITGVIYVNGPLDYETR 1029
Query: 2391 NKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441
Y L VQA A+L V+++I+ + P+F + Y + E +
Sbjct: 1030 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1089
Query: 2442 QLIGRVEASDADAGIDGVILYSL 2464
+ RV+A+D D G V+ Y L
Sbjct: 1090 TSVLRVKATDKDTGNYSVMAYRL 1112
Score = 166 bits (421), Expect = 2e-40
Identities = 250/1019 (24%), Positives = 417/1019 (40%), Gaps = 150/1019 (14%)
Query: 1635 TGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVT 1694
TG + ++P I +Q++ ++ + + ++ + D +F H Y V
Sbjct: 99 TGRV-LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
Query: 1695 ENCEAGTSIVTVKAFAPDS----IQDS----MKYSIFSGNEDGVLSLCSK-----SGQLT 1741
E GT+I T F+ D+ I D ++Y I +D + + +G +
Sbjct: 158 ELTPVGTTIFT--GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 1742 VKEPKFLDFEVRNEVQLIVLAESSGHR------AYCKVAVLIQDENDNSPCFEQSI---- 1791
++ K L++E + +I+ A + V + D +D P F +
Sbjct: 216 LR--KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
Query: 1792 --------YQASVSESQL---YNAHVIQ--VFATDLDSGLN------GLIEYSILSGNQE 1832
YQA++ E + N ++ + A D D + G++ YSIL G E
Sbjct: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPE 332
Query: 1833 EA---FQIDALSGVITTKAILDYELTSSYSLIVQAT-DKGMPRLSNTTVIKVQVTDINDN 1888
+ F + + ++ ++ + + L+++A D G P L + +++ D N+
Sbjct: 333 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQ 391
Query: 1889 APAF-LPSEAVEITEDSLPGVIVT---------HVSVHDVDLNSAFIFSFAKESNPGTKF 1938
+P F +PS I E + G ++ + D D+ N T
Sbjct: 392 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
Query: 1939 AIDQNTGV---VVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQ 1994
TG+ + L++ +D EE Y I D V +E +V ++V+D NDN P F +
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1995 DFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKEFSIDPKNGTIFTISPVL 2052
Y V V + G SV+ L+A D + SN I+Y IL ++ I K + TI+P +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 571
Query: 2053 --------------------------------LLDTISTTQFL--VEASDGGNPDLRALT 2078
LD ST +++ + ASDG PD +
Sbjct: 572 EMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG-RPDGTSTA 630
Query: 2079 LVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSI 2134
V I + D+N+ AP F NLS+ E+ A VG T D D N V YS+
Sbjct: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL 685
Query: 2135 ISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTA 2194
GN N F + + G + L+RE +ELV++A+D P ST
Sbjct: 686 --GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL 732
Query: 2195 VISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE 2254
++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y I S
Sbjct: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEV 790
Query: 2255 KGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDND 2309
K F L TG L L++ LDYE + T V+A D A V V V D ND
Sbjct: 791 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 850
Query: 2310 HAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDH 2367
+ P F + +V + + I ++ A D D P + Y + F Y
Sbjct: 851 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPA 905
Query: 2368 DLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFT 2426
+F ++ +G + + L+ E + L V A D G+ S V I + E P FT
Sbjct: 906 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFT 965
Query: 2427 QDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIR 2484
Q++Y P + G + + A I+ I+YS+ G F +N G IY+
Sbjct: 966 QEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1022
Query: 2485 AL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
L S + + ++++ + + SK + V++ + + P VF F I
Sbjct: 1023 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1079
Score = 139 bits (351), Expect = 3e-32
Identities = 189/830 (22%), Positives = 329/830 (39%), Gaps = 115/830 (13%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
L++ A+ G A + I I F P Y + E P S
Sbjct: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
NG I Y I G F I++ G++ + + R LT++A D + + +LT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 572 --------------VVIEKREHSPSWTFEHLVYQV--EVSES-------LSPMTQMLQTQ 608
++I + P T V V +V+++ L +++ +
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
Query: 609 AHP-LGPQRAASP-------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
A+ +G +A P + YSL + +F I G IY + + E Y
Sbjct: 661 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 717
Query: 661 VFAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718
V A DG + ++ + T+ ++V D +DNSP F + + VEE+ I +I A D
Sbjct: 718 VVA---TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 774
Query: 719 MDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV 778
+D G N FF ++P TG + + + AF E
Sbjct: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITF 823
Query: 779 LKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838
L F G PP AT+ V V D+ND P
Sbjct: 824 LVEAFDIYGT---------------------------MPPGIATVTVIVK--DMNDYPPV 854
Query: 839 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKI 893
F + + + ++G P +TTV+A+D D + V Y V + F++
Sbjct: 855 FSKRIYKGMVAPDAVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 910
Query: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIR 953
+ ++G + T L+ + +++ V+A D G P + A V I V+ + + R
Sbjct: 911 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYR 970
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
+ E ++ +I ++ N + +SIV+ +++ F I++ TG ++++ LD
Sbjct: 971 PPPVSELATKGTMVGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
Query: 1014 YETTSHYLFRV------ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEEN 1067
YET + Y+ RV + + + S S+T + I+++D+N+H P FQ + + V E+
Sbjct: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
Query: 1068 VPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
+ T V A D D G++ + I G F++ G + T
Sbjct: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1135
Score = 123 bits (309), Expect = 2e-27
Identities = 205/889 (23%), Positives = 346/889 (38%), Gaps = 182/889 (20%)
Query: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Query: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEIL 241
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +
Sbjct: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT------ 566
Query: 242 SAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKV 301
+ +EM + GR + ++
Sbjct: 567 ----------IAPGVEMIV-------------------------------GRTYALTVQA 585
Query: 302 QDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDG---GGLTAV 358
D A A+ GI+ L L + L+++A DG G TA
Sbjct: 586 ADNAPPAERST--------------GILTLGKALDRESTDRYILIITASDGRPDGTSTAT 631
Query: 359 INADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIF 412
+N VT +F L P+ +V E+ ++ +G VKA +P + +
Sbjct: 632 VNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVKATDPDAGINGQVH 682
Query: 413 YRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVM 471
Y S G+ F I G+I T L+ E + L V A G+ P S+ + I V+
Sbjct: 683 Y--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 739
Query: 472 DVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAID 530
D++DN P F ++ + + + P GT + A+D D G N + Y I SP+ FA+
Sbjct: 740 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 797
Query: 531 RALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTF 585
G L L SL ++ +T + A D G P V +V + ++ P F
Sbjct: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP--VF 855
Query: 586 EHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP---SVDSAMFGIRPY 639
+Y+ V+ +P+T + A P P AS +RY ++ +++F +
Sbjct: 856 SKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEED 913
Query: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVLF 698
+G + R + E T + V A+ +DG + + S TV + V + P F +
Sbjct: 914 SGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHPGE-IPRFTQE--- 967
Query: 699 LKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGPAGTIYVI 753
E P P + G + + + N ++Y ++S + F +N T G IYV
Sbjct: 968 ---EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT---GVIYV- 1020
Query: 754 TWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD 813
+ + ++VL+ V D + V++ +
Sbjct: 1021 ------------NGPLDYETRTSYVLR--------------VQAD-------SLEVVLAN 1047
Query: 814 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDE 872
P ++ T VY+ + D N++ P F K+ ++ V E + V V A D D
Sbjct: 1048 LRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDT 1102
Query: 873 GNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ 929
GN + + Y + ++ + F ++ G I+T + R ++ VIATD L
Sbjct: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
Query: 930 GQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQ 978
G+A V + V+ + I+S +P L KI L + D Q
Sbjct: 1163 GKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRYVQ 1205
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 667 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 717
Query: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 718 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
Query: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 767 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 820
Query: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
+ + P + + +D F +KG +K
Sbjct: 821 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 875
Query: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 876 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 935
Query: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 936 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 989
Query: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 990 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1046
Query: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 1047 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1106
Query: 514 LIRYSIASP 522
++ Y + P
Sbjct: 1107 VMAYRLIIP 1115
Score = 57.4 bits (137), Expect = 2e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 964 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 1024 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1079
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 1080 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1132
Score = 54.7 bits (130), Expect = 1e-06
Identities = 54/181 (29%), Positives = 77/181 (42%), Gaps = 31/181 (17%)
Query: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
Query: 138 EAKDG--DEQRMTHLALVKGGLSAQ---------------------AFVRVDLEDVNDNH 174
+A D +R T + + L + A V + + DVNDN
Sbjct: 584 QAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 643
Query: 175 PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLY 234
PVF+P E + + V ATD D+GI G V Y L GN ++LF I S +Y
Sbjct: 644 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIY 701
Query: 235 S 235
+
Sbjct: 702 T 702
Score = 36.2 bits (82), Expect = 0.49
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 263 bits (672), Expect = 2e-69
Identities = 232/797 (29%), Positives = 363/797 (45%), Gaps = 83/797 (10%)
Query: 844 PGKELHV--KVLEGQPVNMLVTTVFAKD--PDEGNNAEVTYSVSSEDSSDHFKIDANNGE 899
PG V KV E QP N L+ ++ A PD G+ ++ E + + ++D G+
Sbjct: 54 PGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL------EVGAPYLRVDGKTGD 107
Query: 900 IRTTTILSYDYRP---------------SYRMSVIATDQGVPP--LQGQAVVNIQVIPLS 942
I TT S D + +S+ Q P L+GQ I+V ++
Sbjct: 108 IFTTET-SIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQ----IEVQDIN 162
Query: 943 KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHF----- 997
+ + L IPEN + + +SD NG + + A +
Sbjct: 163 DNTPNFASPVITLAIPENTNIGSLFPIPLASDR-DAGPNGVASYELQAGPEAQELFGLQV 221
Query: 998 --EIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
+ + L + LD E Y + D SS + L + V D ND++P F
Sbjct: 222 AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL-LRVTVLDTNDNAPKF 280
Query: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFL-IHPSFGTL 1114
+ + EN PIG V A D D N+ I+Y L + + G +
Sbjct: 281 ERPSYEAELSENSPIGHSVIQVKANDSDQG-ANAEIEYTFHQAPEVVRRLLRLDRNTGLI 339
Query: 1115 VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVIL--DVNDHNPTF------- 1165
+DRE + T+ +V A D+ N +S AQ+V+ D+ND+ PT
Sbjct: 340 TVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTIEIRGIGL 394
Query: 1166 ISFPN--AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG---- 1219
++ + A++ EDV + V + D DEG N VT +++G+ + F L ++S
Sbjct: 395 VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGD--VPFQLRQASETGSD 451
Query: 1220 -----LLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLY 1274
L TT PLDYE + + ++A+D G P LSS+ +L V V+DVND APVF Q +
Sbjct: 452 SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511
Query: 1275 EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMP-GASFELFEINSDTGEVVTTTILD 1333
E + EN PGE + + A D DSG N++L + + P A+ LF I+ +TGE+ T LD
Sbjct: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571
Query: 1334 REIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ---EPE 1390
RE +E + L+V+ D G PSL T T+L V D ND+ P+F++S Y+ V+EN P
Sbjct: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPV 631
Query: 1391 VVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
+ TV+ D D G N V+ + N D F I +G + ++ + DREQ S +T +
Sbjct: 632 GMVTVI--DGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSFDREQQSTYTFQLKA 687
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSP--SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEG 1508
D G PPRS+ + + + VLD ND++P + P+ + +G V ++A D D G
Sbjct: 688 VDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747
Query: 1509 LNGQTEYFLT-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTV 1567
+N + Y + G F I SG + ++R H D + R T
Sbjct: 748 VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG-KPPRYGTA 806
Query: 1568 IIKVYVTDVNDNDPVLE 1584
++ +YV + N +LE
Sbjct: 807 LVHLYVNETLANRTLLE 823
Score = 216 bits (550), Expect = 3e-55
Identities = 194/697 (27%), Positives = 317/697 (45%), Gaps = 51/697 (7%)
Query: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
C L++E+ ++ +G+P L Q + V D+ND P F + ++ EN N
Sbjct: 132 CILEFEVSITDLV-----QNGSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNI 183
Query: 1285 GEFVTRVEALDRDSGVNSKLQFEIMPGASF-ELF--EINSDTGE----VVTTTILDREIQ 1337
G A DRD+G N +E+ G ELF ++ D E ++ LDRE
Sbjct: 184 GSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERW 243
Query: 1338 EVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVL 1396
+ + L + V+DGG P +S+ + TV D ND+AP+F SY+ E+ EN V V
Sbjct: 244 DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVK 303
Query: 1397 ASDMDAGNNRAVEY--HIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG 1454
A+D D G N +EY H ++ +G ++ +DRE +S +L D G
Sbjct: 304 ANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG 363
Query: 1455 DPPRSSVIHLQVRVLDANDHSPSFPT-----LYYQ---SSVREDAEVGTVVLVLSAVDKD 1506
P+S+ + V V D ND++P+ + +Q +++ ED T V ++ D+D
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 1507 EGLNGQTEY-------FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSI 1559
EG N F +AS + L+T+ LD E +T VA D S
Sbjct: 424 EGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD-SG 482
Query: 1560 QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVV 1619
S+T +KV V DVNDN PV Q+ +V + + + A D D G N +V
Sbjct: 483 NPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELV 542
Query: 1620 FSFAE---TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIH- 1674
+S + +F+I TGEIQ + + E + L++ D+G P+ T ++++
Sbjct: 543 YSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 602
Query: 1675 MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSL 1733
++ D F Y V EN A + + V D +++ ++ S+ N D V+
Sbjct: 603 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI-- 660
Query: 1734 CSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCF--- 1787
++G T+ D E ++ + A G AY V + + DENDN+P
Sbjct: 661 --QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
+ ++ +++L V QV A D DSG+N + YSI GN FQI + SG IT +
Sbjct: 719 SNTSHKLLTPQTRLGET-VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
++ + L+V+ +D+G P T ++ + V +
Sbjct: 778 KEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 215 bits (548), Expect = 4e-55
Identities = 189/677 (27%), Positives = 300/677 (44%), Gaps = 76/677 (11%)
Query: 1849 ILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPG 1907
IL++E++ I G PRL +++V DINDN P F P + I E++ G
Sbjct: 133 ILEFEVS-----ITDLVQNGSPRLLEG---QIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1908 VIVTHVSVHDVDLNSAFIFSFAKESNP------GTKFAIDQNTGV--VVLVKTLDFEEMT 1959
+ D D + S+ ++ P G + A DQ ++++ LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1960 EYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Y+L I++ D + L V VLD NDN P F + Y+ + E+ P+G+SV+ + A
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 2017 TDLE--SNENISYRILSSSKE----FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG 2070
D + +N I Y + + +D G I PV D +ST +F V A D G
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED-LSTLRFSVLAKDRG 363
Query: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
A V + ++DMN+ AP ++ L +D + +NI D E T V
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM--------ANISED-VAEETAV 414
Query: 2131 EYSIISGNSQNNFHVETKFFHSEYPY------------KQVGYLVLLHSLDREASASHEL 2178
+S + T + P+ K+ +L LD E + +
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474
Query: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD 2238
I+A DSG PPLSST + +QV+DVNDN P F+ E+ G I ++A+D D
Sbjct: 475 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 2239 TGSHAEIIYNII-SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS- 2296
+GS+AE++Y++ KG F + TG + + LD E+ + L V A+D
Sbjct: 535 SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQG 594
Query: 2297 FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSP 2356
A V V+VLD ND+ P+FM S ++ V EN+P S + + +D D G ++ S+
Sbjct: 595 TATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--- 651
Query: 2357 CFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIE 2416
D+ F+I TG I + D E + Y ++A D G S V V I
Sbjct: 652 -------EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTIN 704
Query: 2417 GIDEFEPIFTQDQYFFTLPEKNKDRQL---------IGRVEASDADAGIDGVILYSLGTS 2467
+DE + + T P + L + +V A D D+G++ ++YS+
Sbjct: 705 VLDE-----NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
Query: 2468 SPF--FSVNKTNGNIYL 2482
+P+ F + +G I L
Sbjct: 760 NPYGLFQIGSHSGAITL 776
Score = 214 bits (546), Expect = 8e-55
Identities = 195/701 (27%), Positives = 305/701 (43%), Gaps = 68/701 (9%)
Query: 680 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 739
+ V D NDN+P F V+ L + E+ + A D D+G NG Y L
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL-------- 207
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
GP A G A +E Q +LI LDR
Sbjct: 208 ---QAGPE-----------AQELFGLQVAEDQEEKQP-------------QLIVMGNLDR 240
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E +++T+ V D GSPPR ++ + V+V D NDN P F + P E ++ E P+
Sbjct: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFER--PSYE--AELSENSPIG 296
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV--SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMS 917
V V A D D+G NAE+ Y+ + E ++D N G I + + + R S
Sbjct: 297 HSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS 356
Query: 918 VIATDQGVPPLQGQAVVNIQVIPLS--------KGRAIMSQNIRHLIIPENLKPTKIMSL 969
V+A D+G P +A V + V ++ +G +++ I E++ ++L
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 970 IKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD-------LFLSKELDYETTSHYLF 1022
++ SD + +VA D S TG L + LDYE Y
Sbjct: 417 VQVSD--RDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474
Query: 1023 RVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDD 1082
++ D S N LSST L + V D ND++P F + ++ EN G ++ A D
Sbjct: 475 EIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 1083 DGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVT 1142
D S N+ + Y +E F I P G + + LDRE + L V A+D+ +
Sbjct: 534 D-SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG---S 589
Query: 1143 DRRLRSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY 1201
+ T + +LD ND++P F +S N V E++ S V +T D D+G N +V
Sbjct: 590 PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649
Query: 1202 SILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLD 1261
S+ +N F++ +G + ++ D E ++ + + A+D G P S+ +T+ VLD
Sbjct: 650 SV--EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
Query: 1262 VNDEAPVF--KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEI 1319
ND AP + + GE V++V A D DSGVN++L + I G + LF+I
Sbjct: 708 ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI 767
Query: 1320 NSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
S +G + ++R + L V V D G P T +
Sbjct: 768 GSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Score = 207 bits (528), Expect = 9e-53
Identities = 222/825 (26%), Positives = 353/825 (42%), Gaps = 87/825 (10%)
Query: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNT-LDREAR 1545
V E+ T++ L+A D G + + + +D +G + T+ T +DRE
Sbjct: 64 VPEEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120
Query: 1546 SQHTFSAVARDCSIQGSRSTTVIIK----------VYVTDVNDNDPVLEQNPFDVFLSPE 1595
+ C ++ S T +++ + V D+NDN P + +
Sbjct: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180
Query: 1596 SPTNQTTVIVRADDLDLGPNGTVVFSFA---ETQSMFSIDKYTGEIQFQQNPS------- 1645
+ I A D D GPNG + E Q +F + E Q ++ P
Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQ--VAEDQEEKQPQLIVMGNL 238
Query: 1646 --SEYFPIWLQLKVTDQGIPARTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ L +KV D G P R ++ LL V ++ D F Y+ ++EN G S
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 1703 IVTVKAFAPDSIQDS-MKYSIFSGNE--DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLI 1759
++ VKA D ++ ++Y+ E +L L +G +TV+ P +D E + ++
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGP--VDREDLSTLRFS 356
Query: 1760 VLAESSGHR---AYCKVAVLIQDENDNSPCFE--------QSIYQASVSESQLYNAHVIQ 1808
VLA+ G A +V V ++D NDN+P E A++SE V
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGV---------ITTKAILDYELTSSYS 1859
V +D D G N + +++G + FQ+ S + T LDYE Y+
Sbjct: 417 VQVSDRDEGENAAVT-CVVAG--DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYT 473
Query: 1860 LIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDV 1918
+ + A D G P LS+T +KVQV D+NDNAP F S V E++ PG ++ ++ D
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 1919 DLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISD----SVH 1972
D S ++ E P K F I TG + + +LD E+ YEL + +D S+
Sbjct: 534 DSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
Query: 1973 YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
T ++V VLD NDN P F Y +V E++P V ++ D + EN + +
Sbjct: 594 GT-ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE 652
Query: 2031 SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNY 2090
+ +F I GTI + S + ST F ++A DGG P A V I + D N+
Sbjct: 653 QDNGDFVIQNGTGTILS-SLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
Query: 2091 APEFTVKSYNLS---LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
AP T S N S L+ +G T+ + D D + N + YSI GN F + +
Sbjct: 712 APYITAPS-NTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAGGNPYGLFQIGS 769
Query: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
HS G + L ++R H LV+ SD G PP TA++ + V + N
Sbjct: 770 ---HS-------GAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANR 819
Query: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISG 2252
+L H+ TPL I +R + I++ +++G
Sbjct: 820 TLLETLLGHS---LDTPLDIDIAGDPEYER-SKQRGNILFGVVAG 860
Score = 206 bits (523), Expect = 4e-52
Identities = 180/699 (25%), Positives = 314/699 (44%), Gaps = 69/699 (9%)
Query: 1744 EPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYN 1803
+P L+FEV I +G + + +QD NDN+P F + ++ E+
Sbjct: 130 DPCILEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1804 AHVIQVFATDLDSGLNGLIEYSILSGNQ-EEAFQIDALSGV------ITTKAILDYELTS 1856
+ A+D D+G NG+ Y + +G + +E F + + LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-LPSEAVEITEDSLPGVIVTHVSV 1915
SY L ++ D G P +++ +++V V D NDNAP F PS E++E+S G V V
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 1916 HDVD--LNSAFIFSFAKESNPGTKFA-IDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH 1972
+D D N+ ++F + + +D+NTG++ + +D E+++ + D
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
Query: 1973 YTEGA---LVVRVLDVNDNPP---------VFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
+ A +VV V D+NDN P V QD + E + +V + +D +
Sbjct: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDG-MANISEDVAEETAVALVQVSDRD 423
Query: 2021 SNEN----------ISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE--ASD 2068
EN + +++ +S+ S K + T +P LD + +E A D
Sbjct: 424 EGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP---LDYEKVKDYTIEIVAVD 480
Query: 2069 GGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128
GNP L + +++ + D+N+ AP FT ++ E+ G + + D D + N
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNA 539
Query: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188
+ YS+ + + + G + + SLDRE S+EL ++A+D G P
Sbjct: 540 ELVYSLEPEPAAKGLFTISP---------ETGEIQVKTSLDREQRESYELKVVAADRGSP 590
Query: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
L TA + + VLD NDN P F Y+ V E+ P S + +V+ D D G +A++ +
Sbjct: 591 SLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLS 650
Query: 2249 IISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDD 2307
+ N G F ++ TG + D E+ + +T ++A D ++ V ++VLD+
Sbjct: 651 VEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
Query: 2308 NDHAPQFMF---SSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMS 2364
ND+AP +S + P+ + T+ + A DFD+G EL YSI
Sbjct: 709 NDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFDSGVNAELIYSIAG--------G 759
Query: 2365 YDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
+ LF I +G I ++ ++ + + L V+ D+G
Sbjct: 760 NPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Score = 195 bits (496), Expect = 5e-49
Identities = 171/584 (29%), Positives = 268/584 (45%), Gaps = 61/584 (10%)
Query: 1748 LDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNA 1804
LD E + L + + G A+L + D NDN+P FE+ Y+A +SE+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 1805 HVIQVFATDLDSGLNGLIEYSILSGNQ--EEAFQIDALSGVITTKAILDYELTSSYSLIV 1862
VIQV A D D G N IEY+ + ++D +G+IT + +D E S+ V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 1863 QATDKGMPRLSNTTVIKVQVTDINDNAPAFL---------PSEAVEITEDSLPGVIVTHV 1913
A D+G S + V V D+NDNAP I+ED V V
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 1914 SVHDVDL--NSAFI--------FSFAKESNPGT----KFAIDQNTGVVVLVKTLDFEEMT 1959
V D D N+A F + S G+ K+ + T LD+E++
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------PLDYEKVK 470
Query: 1960 EYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
+Y + I DS + + +L V+V+DVNDN PVF+Q +V PE+ G + ++A
Sbjct: 471 DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITA 530
Query: 2017 TDLESNENISYRILSSSKE------FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG 2070
+D +S N + S E F+I P+ G I + L + + + V A+D G
Sbjct: 531 SDADSGSNAEL-VYSLEPEPAAKGLFTISPETGEI-QVKTSLDREQRESYELKVVAADRG 588
Query: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
+P L+ V + + D N+ P+F + YN S+ E+ S + + ID D EN V
Sbjct: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD-KGENAQV 647
Query: 2131 EYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPL 2190
+ S+ N +F ++ G ++ S DRE +++ + A D G PP
Sbjct: 648 QLSVEQDNG--DFVIQNG----------TGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695
Query: 2191 SSTAVISIQVLDVNDNPPNFSSLSYHTH--VKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
S+ ++I VLD NDN P ++ S +H + T LG ++ V+A D D+G +AE+IY+
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755
Query: 2249 IISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEK 2292
I GN G F + ++G + L K ++ L V+ SD K
Sbjct: 756 IAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGK 799
Score = 174 bits (441), Expect = 1e-42
Identities = 162/607 (26%), Positives = 259/607 (42%), Gaps = 73/607 (12%)
Query: 439 LDHETQPVVVLTVQAQLG-SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497
LD E LT++ Q G S P SS + +TV+D NDN P F R S E +S+ +P G
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 498 ALYLARAEDRDSGRNGLIRYSIASPQPGV---FAIDRALGVLFLNGSLGAGEQRELTLTL 554
++ +A D D G N I Y+ V +DR G++ + G + + L ++
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 555 RAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFE------HLVYQVEVSESLSPMT--QML 605
A+D+G +P++A V+ V + +++P+ H +SE ++ T ++
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 606 QTQAHPLGPQRA-----ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
Q G A A + + L + ++ + Y ++ DYE + Y
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY--FLQTTTPLDYEKVKDYTIE 475
Query: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
+ A + + + ++ V+V D NDN+P F V + E+ P VI +ITA D D
Sbjct: 476 IVA-VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 721 SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
SG N +L+Y + P G F S +
Sbjct: 535 SGSNAELVY---------SLEPEPAAKGL-----------------FTISPE-------- 560
Query: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 840
GE+ +LDRE R +E+ V+ DRGSP T V V+V D NDN P F
Sbjct: 561 -------TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF- 612
Query: 841 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI 900
L G + V+E P V V D D+G NA+V SV E + F I G I
Sbjct: 613 -MLSG--YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--EQDNGDFVIQNGTGTI 667
Query: 901 RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS--QNIRHLIIP 958
++ + + +Y + A D GVPP V I V+ + ++ N H ++
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLT 727
Query: 959 ENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTS 1018
+ + +S + + D N +L +SI + G F+I S +G + L KE+ E
Sbjct: 728 PQTRLGETVSQVAAED-FDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI--ERRH 784
Query: 1019 HYLFRVI 1025
H L R++
Sbjct: 785 HGLHRLV 791
Score = 171 bits (433), Expect = 1e-41
Identities = 197/807 (24%), Positives = 331/807 (41%), Gaps = 100/807 (12%)
Query: 372 LAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKF-SIHPRL 430
LAP+ + + V E+ P ++ IG++ A + P + ++G + + +
Sbjct: 50 LAPSPGHATRVVYKVPEEQPPNTLIGSLAA----DYGFPDVGHLYKLEVGAPYLRVDGKT 105
Query: 431 GTI-RTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNIT----------------VMDV 473
G I T +D E + Q QL P EV+IT V D+
Sbjct: 106 GDIFTTETSIDREG----LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI 161
Query: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-ASPQ-PGVFAI-- 529
NDN P F + I + T G+ + A DRD+G NG+ Y + A P+ +F +
Sbjct: 162 NDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQV 221
Query: 530 ----DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWT 584
+ L + G+L LT++ +D G P+A+ +L V V++ +++P
Sbjct: 222 AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPK-- 279
Query: 585 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE--PSVDSAMFGIRPYTGW 642
FE Y+ E+SE+ ++Q +A+ Q A + + Y+ P V + + TG
Sbjct: 280 FERPSYEAELSENSPIGHSVIQVKAND-SDQGANAEIEYTFHQAPEVVRRLLRLDRNTGL 338
Query: 643 IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF--------LH 694
I ++ D E T F V A ++ V+V V D NDN+PT H
Sbjct: 339 ITVQGPVDREDLSTLRFSVLA-KDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGPAGTIYVI 753
+ E + + + D D G+N + + D F + TG
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETG-------- 449
Query: 754 TWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD 813
SD + + L++ LD E + + ++ D
Sbjct: 450 -----------------SDSKKKYFLQTT------------TPLDYEKVKDYTIEIVAVD 480
Query: 814 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 873
G+PP ++T ++ V V D+NDN P F Q + V E ++ + A D D G
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSV----TEVAFPENNKPGEVIAEITASDADSG 536
Query: 874 NNAEVTYSVSSEDSSDH-FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQA 932
+NAE+ YS+ E ++ F I GEI+ T L + R SY + V+A D+G P LQG A
Sbjct: 537 SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
Query: 933 VVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD 992
V + V+ + + + + EN+ + ++ D + N ++ S+ D
Sbjct: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDG-DKGENAQVQLSVEQD- 654
Query: 993 KDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052
+G F I + TG + S D E S Y F++ D S+ V ++I+V D+ND++
Sbjct: 655 -NGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNA 712
Query: 1053 P--SFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
P + + +G V A+D D S +N+ + Y I NP F I
Sbjct: 713 PYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAGGNP-YGLFQIGSH 770
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQ 1137
G + ++R L V SD+
Sbjct: 771 SGAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 164 bits (414), Expect = 2e-39
Identities = 145/563 (25%), Positives = 246/563 (43%), Gaps = 48/563 (8%)
Query: 2001 VPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTT 2060
VPE P + +L+A + Y++ + +D K G IFT + + +
Sbjct: 64 VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123
Query: 2061 Q-----------FLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
Q F V +D L +I ++D+N+ P F L++ E+ +
Sbjct: 124 QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI 183
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
GS D D N Y + +G +Q F ++ +E ++ L+++ +L
Sbjct: 184 GSLFPIPLASDRD-AGPNGVASYELQAGPEAQELFGLQV----AEDQEEKQPQLIVMGNL 238
Query: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH 2228
DRE S++L I D G PP +S+A++ + VLD NDN P F SY + E++P+G
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 2229 ITVVSANDRDTGSHAEIIYNIISGNE--KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
+ V AND D G++AEI Y E + L+ NTG++ + P+D E ++ +V
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL 358
Query: 2287 ASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI--------VPENLPISSTICSIN 2337
A D + A V V+V D ND+AP + + E++ + + +
Sbjct: 359 AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQ 418
Query: 2338 ALDFDAGPYGELTYSIVS--PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCL 2395
D D G +T + P L D + LDYE Y +
Sbjct: 419 VSDRDEGENAAVTCVVAGDVPFQLRQASETGSD----SKKKYFLQTTTPLDYEKVKDYTI 474
Query: 2396 TVQAKDKGDATASLV--VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
+ A D G+ S + V + +++ P+FTQ PE NK ++I + ASDAD
Sbjct: 475 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 2454 AGIDGVILYSL---GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKE--DTLEMKIIAHSP 2508
+G + ++YSL + F+++ G I +K+ L++E ++ E+K++A
Sbjct: 535 SGSNAELVYSLEPEPAAKGLFTISPETGEIQ-------VKTSLDREQRESYELKVVAADR 587
Query: 2509 KSDSKFASCTVFVNVSFSSEGTP 2531
S S + TV VNV ++ P
Sbjct: 588 GSPSLQGTATVLVNVLDCNDNDP 610
Score = 158 bits (400), Expect = 7e-38
Identities = 163/668 (24%), Positives = 270/668 (40%), Gaps = 78/668 (11%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP 404
L + QDGG +A + + + T +FERP Y + E+ P + VKA +
Sbjct: 248 LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307
Query: 405 ---LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPA 460
N+ + + + + G I + P+D E + +V A+ G+ P
Sbjct: 308 DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367
Query: 461 CSSTEVNITVMDVNDNHPAF------LRTSDE--IRISQTTPPGTALYLARAEDRDSGRN 512
+ +V +TV D+NDN P L T + IS+ TA+ L + DRD G N
Sbjct: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 513 GLIRYSIASPQPGVFAIDRALG-------VLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 565
+ +A P G L L + ++ T+ + A D G P +
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS 487
Query: 566 ALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
+ L V V++ +++P F V +V E+ P + + A A L YS
Sbjct: 488 STNSLKVQVVDVNDNAP--VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE-LVYS 544
Query: 625 LEPS-VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
LEP +F I P TG I ++ D E ++Y +V A LQ +T V+V V
Sbjct: 545 LEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT-VLVNVL 603
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-GKFFKMNP 742
D NDN P F+ V E+ +G +T ID D G+N Q+ + D G F N
Sbjct: 604 DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQN- 662
Query: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
G G +++ ++ DRE +
Sbjct: 663 --------------------------------------------GTGTILSSLSFDREQQ 678
Query: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
+ + D G PPR+A + V ++V D NDN P+ P H + + V
Sbjct: 679 STYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI--TAPSNTSHKLLTPQTRLGETV 736
Query: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
+ V A+D D G NAE+ YS++ + F+I +++G I + + +R+ V +D
Sbjct: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Query: 923 QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
+G PP G A+V++ V R ++ + H +L + + ++ + G
Sbjct: 797 RGKPPRYGTALVHLYVNETLANRTLLETLLGH-----SLDTPLDIDIAGDPEYERSKQRG 851
Query: 983 KLHFSIVA 990
+ F +VA
Sbjct: 852 NILFGVVA 859
Score = 135 bits (340), Expect = 6e-31
Identities = 194/824 (23%), Positives = 318/824 (38%), Gaps = 161/824 (19%)
Query: 89 YGFIEYS-LYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDRER----------DPATYDLL 136
YGF + LY L AP R+D G I ++ IDRE DP +
Sbjct: 81 YGFPDVGHLYK--LEVGAPY-LRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFE 137
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
V D LV+ G +++++D+NDN P F +I + T G+
Sbjct: 138 VSITD----------LVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLF 187
Query: 197 INVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
LA+D+D+G G +YEL G LF + + +++ N D+E +S
Sbjct: 188 PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL--DRERWDS 245
Query: 256 LEMFLP-------------LLR--------HFKKVERDEEAAEKKFEASRGWFMRFKGRR 294
++ + LLR + K ER AE + G
Sbjct: 246 YDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIG--------H 297
Query: 295 HLHYLKVQDEAASADGEA------AARYVANLAKI-LGEGIIYLTLPLSHLESTTLSLMV 347
+ +K D A+ E A V L ++ G+I + P+ + +TL V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY--------EDVPEDSPIGTV 399
A+D G A V + + E + + EDV E++ + V
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 400 KAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT-------IRTRKPLDHE-TQPVVVLTV 451
+ + + +GD+ + G+ ++T PLD+E + + V
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIV 477
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
G+ P S+ + + V+DVNDN P F ++ E+ + PG + A D DSG
Sbjct: 478 AVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGS 537
Query: 512 NGLIRYSIASPQP---GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAAL 567
N + YS+ P+P G+F I G + + SL ++ L + A D+G Q
Sbjct: 538 NAELVYSL-EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
Query: 568 LVLTVVIEKREHSPSWTFEHLVYQV-EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 626
VL V++ ++ P + + V E +LSP+ + G + + ++ S+E
Sbjct: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID----GDKGENAQVQLSVE 652
Query: 627 PSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVIVRVWD 684
D+ F I+ TG I FD E TY F++ A DG + ++ V + V D
Sbjct: 653 Q--DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKA---VDGGVPPRSAYVGVTINVLD 707
Query: 685 ENDNSPTFL------HDVLFLKVEESPVPQGVIG----KITAIDMDSGKNGQLLYFLLSD 734
ENDN+P H +L PQ +G ++ A D DSG N +L+Y +
Sbjct: 708 ENDNAPYITAPSNTSHKLL--------TPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
Query: 735 GKF--FKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELI 792
+ F++ ++G A L+
Sbjct: 760 NPYGLFQIGSHSG------------------------------AITLEK----------- 778
Query: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
++R H G H + V V+DRG PPR T V++ V + NR
Sbjct: 779 ---EIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANR 819
Score = 107 bits (267), Expect = 2e-22
Identities = 164/719 (22%), Positives = 276/719 (38%), Gaps = 162/719 (22%)
Query: 27 DACVYEVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEEN----AKPV------KE 76
D C+ E V I +V++ GSP L G I + +N A PV +
Sbjct: 130 DPCILEFEVSITDLVQN--------GSPRL-LEGQIEVQDINDNTPNFASPVITLAIPEN 180
Query: 77 TEV-------TASDADSGLYGFIEYSLYDGFLSYEAPQAFRI------DPHDGQICVSQD 123
T + ASD D+G G Y L G EA + F + + Q+ V +
Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAG---PEAQELFGLQVAEDQEEKQPQLIVMGN 237
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+DRER + YDL ++ +DG ++ A +RV + D NDN P F +Y
Sbjct: 238 LDRERWDS-YDLTIKVQDGGSPPR----------ASSALLRVTVLDTNDNAPKFERPSYE 286
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGLYSPEVEIL 241
+S+ + G +I V A D D G + Y P V L +D TGL +
Sbjct: 287 AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLIT------ 340
Query: 242 SAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKV 301
V D+E +++L F + +D K A + V
Sbjct: 341 --VQGPVDREDLSTL--------RFSVLAKDRGTNPKSARAQ-------------VVVTV 377
Query: 302 QDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHL-----ESTTLSLM-VSAQDGG-- 353
+D +A +I G G++ ++++ E T ++L+ VS +D G
Sbjct: 378 KDMNDNAP----------TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 354 -GLTAVINADVTIHI--------------FQTTLAPAEFERPK-YTFLVYE--------- 388
+T V+ DV + F T P ++E+ K YT +
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS 487
Query: 389 ----------DVPEDSPIGTVKAREPL----NSSEPIFYRISSGDLG------------- 421
DV +++P+ T E N + I++ D
Sbjct: 488 STNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP 547
Query: 422 -----GKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVND 475
G F+I P G I+ + LD E + L V A +P+ T V + V+D ND
Sbjct: 548 EPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCND 607
Query: 476 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV 535
N P F+ + + + P + + + D D G N ++ S+ G F I G
Sbjct: 608 NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-GDFVIQNGTGT 666
Query: 536 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEV 594
+ + S +Q T L+A D GV P++A + +T+ V+++ +++P T
Sbjct: 667 ILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH--- 723
Query: 595 SESLSPMTQMLQTQAHPLG---PQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 650
+ L+P T++ +T + + L YS+ +F I ++G I L ++ +
Sbjct: 724 -KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 263 bits (672), Expect = 2e-69
Identities = 232/797 (29%), Positives = 363/797 (45%), Gaps = 83/797 (10%)
Query: 844 PGKELHV--KVLEGQPVNMLVTTVFAKD--PDEGNNAEVTYSVSSEDSSDHFKIDANNGE 899
PG V KV E QP N L+ ++ A PD G+ ++ E + + ++D G+
Sbjct: 54 PGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKL------EVGAPYLRVDGKTGD 107
Query: 900 IRTTTILSYDYRP---------------SYRMSVIATDQGVPP--LQGQAVVNIQVIPLS 942
I TT S D + +S+ Q P L+GQ I+V ++
Sbjct: 108 IFTTET-SIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQ----IEVQDIN 162
Query: 943 KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHF----- 997
+ + L IPEN + + +SD NG + + A +
Sbjct: 163 DNTPNFASPVITLAIPENTNIGSLFPIPLASDR-DAGPNGVASYELQAGPEAQELFGLQV 221
Query: 998 --EIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
+ + L + LD E Y + D SS + L + V D ND++P F
Sbjct: 222 AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSAL-LRVTVLDTNDNAPKF 280
Query: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFL-IHPSFGTL 1114
+ + EN PIG V A D D N+ I+Y L + + G +
Sbjct: 281 ERPSYEAELSENSPIGHSVIQVKANDSDQG-ANAEIEYTFHQAPEVVRRLLRLDRNTGLI 339
Query: 1115 VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVIL--DVNDHNPTF------- 1165
+DRE + T+ +V A D+ N +S AQ+V+ D+ND+ PT
Sbjct: 340 TVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTIEIRGIGL 394
Query: 1166 ISFPN--AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG---- 1219
++ + A++ EDV + V + D DEG N VT +++G+ + F L ++S
Sbjct: 395 VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGD--VPFQLRQASETGSD 451
Query: 1220 -----LLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLY 1274
L TT PLDYE + + ++A+D G P LSS+ +L V V+DVND APVF Q +
Sbjct: 452 SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511
Query: 1275 EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMP-GASFELFEINSDTGEVVTTTILD 1333
E + EN PGE + + A D DSG N++L + + P A+ LF I+ +TGE+ T LD
Sbjct: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571
Query: 1334 REIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ---EPE 1390
RE +E + L+V+ D G PSL T T+L V D ND+ P+F++S Y+ V+EN P
Sbjct: 572 REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPV 631
Query: 1391 VVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
+ TV+ D D G N V+ + N D F I +G + ++ + DREQ S +T +
Sbjct: 632 GMVTVI--DGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSFDREQQSTYTFQLKA 687
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSP--SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEG 1508
D G PPRS+ + + + VLD ND++P + P+ + +G V ++A D D G
Sbjct: 688 VDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSG 747
Query: 1509 LNGQTEYFLT-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTV 1567
+N + Y + G F I SG + ++R H D + R T
Sbjct: 748 VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG-KPPRYGTA 806
Query: 1568 IIKVYVTDVNDNDPVLE 1584
++ +YV + N +LE
Sbjct: 807 LVHLYVNETLANRTLLE 823
Score = 216 bits (550), Expect = 3e-55
Identities = 194/697 (27%), Positives = 317/697 (45%), Gaps = 51/697 (7%)
Query: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
C L++E+ ++ +G+P L Q + V D+ND P F + ++ EN N
Sbjct: 132 CILEFEVSITDLV-----QNGSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNI 183
Query: 1285 GEFVTRVEALDRDSGVNSKLQFEIMPGASF-ELF--EINSDTGE----VVTTTILDREIQ 1337
G A DRD+G N +E+ G ELF ++ D E ++ LDRE
Sbjct: 184 GSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERW 243
Query: 1338 EVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVL 1396
+ + L + V+DGG P +S+ + TV D ND+AP+F SY+ E+ EN V V
Sbjct: 244 DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVK 303
Query: 1397 ASDMDAGNNRAVEY--HIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG 1454
A+D D G N +EY H ++ +G ++ +DRE +S +L D G
Sbjct: 304 ANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG 363
Query: 1455 DPPRSSVIHLQVRVLDANDHSPSFPT-----LYYQ---SSVREDAEVGTVVLVLSAVDKD 1506
P+S+ + V V D ND++P+ + +Q +++ ED T V ++ D+D
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 1507 EGLNGQTEY-------FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSI 1559
EG N F +AS + L+T+ LD E +T VA D S
Sbjct: 424 EGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVD-SG 482
Query: 1560 QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVV 1619
S+T +KV V DVNDN PV Q+ +V + + + A D D G N +V
Sbjct: 483 NPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELV 542
Query: 1620 FSFAE---TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIH- 1674
+S + +F+I TGEIQ + + E + L++ D+G P+ T ++++
Sbjct: 543 YSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 602
Query: 1675 MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSL 1733
++ D F Y V EN A + + V D +++ ++ S+ N D V+
Sbjct: 603 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI-- 660
Query: 1734 CSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCF--- 1787
++G T+ D E ++ + A G AY V + + DENDN+P
Sbjct: 661 --QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAP 718
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
+ ++ +++L V QV A D DSG+N + YSI GN FQI + SG IT +
Sbjct: 719 SNTSHKLLTPQTRLGET-VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLE 777
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
++ + L+V+ +D+G P T ++ + V +
Sbjct: 778 KEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 215 bits (548), Expect = 4e-55
Identities = 189/677 (27%), Positives = 300/677 (44%), Gaps = 76/677 (11%)
Query: 1849 ILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPG 1907
IL++E++ I G PRL +++V DINDN P F P + I E++ G
Sbjct: 133 ILEFEVS-----ITDLVQNGSPRLLEG---QIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1908 VIVTHVSVHDVDLNSAFIFSFAKESNP------GTKFAIDQNTGV--VVLVKTLDFEEMT 1959
+ D D + S+ ++ P G + A DQ ++++ LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1960 EYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Y+L I++ D + L V VLD NDN P F + Y+ + E+ P+G+SV+ + A
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 2017 TDLE--SNENISYRILSSSKE----FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG 2070
D + +N I Y + + +D G I PV D +ST +F V A D G
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED-LSTLRFSVLAKDRG 363
Query: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
A V + ++DMN+ AP ++ L +D + +NI D E T V
Sbjct: 364 TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM--------ANISED-VAEETAV 414
Query: 2131 EYSIISGNSQNNFHVETKFFHSEYPY------------KQVGYLVLLHSLDREASASHEL 2178
+S + T + P+ K+ +L LD E + +
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474
Query: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD 2238
I+A DSG PPLSST + +QV+DVNDN P F+ E+ G I ++A+D D
Sbjct: 475 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 2239 TGSHAEIIYNII-SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS- 2296
+GS+AE++Y++ KG F + TG + + LD E+ + L V A+D
Sbjct: 535 SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQG 594
Query: 2297 FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSP 2356
A V V+VLD ND+ P+FM S ++ V EN+P S + + +D D G ++ S+
Sbjct: 595 TATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--- 651
Query: 2357 CFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIE 2416
D+ F+I TG I + D E + Y ++A D G S V V I
Sbjct: 652 -------EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTIN 704
Query: 2417 GIDEFEPIFTQDQYFFTLPEKNKDRQL---------IGRVEASDADAGIDGVILYSLGTS 2467
+DE + + T P + L + +V A D D+G++ ++YS+
Sbjct: 705 VLDE-----NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
Query: 2468 SPF--FSVNKTNGNIYL 2482
+P+ F + +G I L
Sbjct: 760 NPYGLFQIGSHSGAITL 776
Score = 214 bits (546), Expect = 8e-55
Identities = 195/701 (27%), Positives = 305/701 (43%), Gaps = 68/701 (9%)
Query: 680 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 739
+ V D NDN+P F V+ L + E+ + A D D+G NG Y L
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL-------- 207
Query: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
GP A G A +E Q +LI LDR
Sbjct: 208 ---QAGPE-----------AQELFGLQVAEDQEEKQP-------------QLIVMGNLDR 240
Query: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
E +++T+ V D GSPPR ++ + V+V D NDN P F + P E ++ E P+
Sbjct: 241 ERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFER--PSYE--AELSENSPIG 296
Query: 860 MLVTTVFAKDPDEGNNAEVTYSV--SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMS 917
V V A D D+G NAE+ Y+ + E ++D N G I + + + R S
Sbjct: 297 HSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS 356
Query: 918 VIATDQGVPPLQGQAVVNIQVIPLS--------KGRAIMSQNIRHLIIPENLKPTKIMSL 969
V+A D+G P +A V + V ++ +G +++ I E++ ++L
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 970 IKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGD-------LFLSKELDYETTSHYLF 1022
++ SD + +VA D S TG L + LDYE Y
Sbjct: 417 VQVSD--RDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474
Query: 1023 RVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDD 1082
++ D S N LSST L + V D ND++P F + ++ EN G ++ A D
Sbjct: 475 EIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 1083 DGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVT 1142
D S N+ + Y +E F I P G + + LDRE + L V A+D+ +
Sbjct: 534 D-SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG---S 589
Query: 1143 DRRLRSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY 1201
+ T + +LD ND++P F +S N V E++ S V +T D D+G N +V
Sbjct: 590 PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649
Query: 1202 SILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLD 1261
S+ +N F++ +G + ++ D E ++ + + A+D G P S+ +T+ VLD
Sbjct: 650 SV--EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
Query: 1262 VNDEAPVF--KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEI 1319
ND AP + + GE V++V A D DSGVN++L + I G + LF+I
Sbjct: 708 ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI 767
Query: 1320 NSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
S +G + ++R + L V V D G P T +
Sbjct: 768 GSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Score = 207 bits (528), Expect = 9e-53
Identities = 222/825 (26%), Positives = 353/825 (42%), Gaps = 87/825 (10%)
Query: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNT-LDREAR 1545
V E+ T++ L+A D G + + + +D +G + T+ T +DRE
Sbjct: 64 VPEEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGL 120
Query: 1546 SQHTFSAVARDCSIQGSRSTTVIIK----------VYVTDVNDNDPVLEQNPFDVFLSPE 1595
+ C ++ S T +++ + V D+NDN P + +
Sbjct: 121 RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPEN 180
Query: 1596 SPTNQTTVIVRADDLDLGPNGTVVFSFA---ETQSMFSIDKYTGEIQFQQNPS------- 1645
+ I A D D GPNG + E Q +F + E Q ++ P
Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQ--VAEDQEEKQPQLIVMGNL 238
Query: 1646 --SEYFPIWLQLKVTDQGIPARTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
+ L +KV D G P R ++ LL V ++ D F Y+ ++EN G S
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 1703 IVTVKAFAPDSIQDS-MKYSIFSGNE--DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLI 1759
++ VKA D ++ ++Y+ E +L L +G +TV+ P +D E + ++
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGP--VDREDLSTLRFS 356
Query: 1760 VLAESSGHR---AYCKVAVLIQDENDNSPCFE--------QSIYQASVSESQLYNAHVIQ 1808
VLA+ G A +V V ++D NDN+P E A++SE V
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGV---------ITTKAILDYELTSSYS 1859
V +D D G N + +++G + FQ+ S + T LDYE Y+
Sbjct: 417 VQVSDRDEGENAAVT-CVVAG--DVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYT 473
Query: 1860 LIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDV 1918
+ + A D G P LS+T +KVQV D+NDNAP F S V E++ PG ++ ++ D
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 1919 DLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISD----SVH 1972
D S ++ E P K F I TG + + +LD E+ YEL + +D S+
Sbjct: 534 DSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
Query: 1973 YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
T ++V VLD NDN P F Y +V E++P V ++ D + EN + +
Sbjct: 594 GT-ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVE 652
Query: 2031 SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNY 2090
+ +F I GTI + S + ST F ++A DGG P A V I + D N+
Sbjct: 653 QDNGDFVIQNGTGTILS-SLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
Query: 2091 APEFTVKSYNLS---LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
AP T S N S L+ +G T+ + D D + N + YSI GN F + +
Sbjct: 712 APYITAPS-NTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAGGNPYGLFQIGS 769
Query: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
HS G + L ++R H LV+ SD G PP TA++ + V + N
Sbjct: 770 ---HS-------GAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANR 819
Query: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISG 2252
+L H+ TPL I +R + I++ +++G
Sbjct: 820 TLLETLLGHS---LDTPLDIDIAGDPEYER-SKQRGNILFGVVAG 860
Score = 206 bits (523), Expect = 4e-52
Identities = 180/699 (25%), Positives = 314/699 (44%), Gaps = 69/699 (9%)
Query: 1744 EPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYN 1803
+P L+FEV I +G + + +QD NDN+P F + ++ E+
Sbjct: 130 DPCILEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1804 AHVIQVFATDLDSGLNGLIEYSILSGNQ-EEAFQIDALSGV------ITTKAILDYELTS 1856
+ A+D D+G NG+ Y + +G + +E F + + LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-LPSEAVEITEDSLPGVIVTHVSV 1915
SY L ++ D G P +++ +++V V D NDNAP F PS E++E+S G V V
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 1916 HDVD--LNSAFIFSFAKESNPGTKFA-IDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH 1972
+D D N+ ++F + + +D+NTG++ + +D E+++ + D
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
Query: 1973 YTEGA---LVVRVLDVNDNPP---------VFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
+ A +VV V D+NDN P V QD + E + +V + +D +
Sbjct: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDG-MANISEDVAEETAVALVQVSDRD 423
Query: 2021 SNEN----------ISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE--ASD 2068
EN + +++ +S+ S K + T +P LD + +E A D
Sbjct: 424 EGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP---LDYEKVKDYTIEIVAVD 480
Query: 2069 GGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128
GNP L + +++ + D+N+ AP FT ++ E+ G + + D D + N
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNA 539
Query: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188
+ YS+ + + + G + + SLDRE S+EL ++A+D G P
Sbjct: 540 ELVYSLEPEPAAKGLFTISP---------ETGEIQVKTSLDREQRESYELKVVAADRGSP 590
Query: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
L TA + + VLD NDN P F Y+ V E+ P S + +V+ D D G +A++ +
Sbjct: 591 SLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLS 650
Query: 2249 IISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDD 2307
+ N G F ++ TG + D E+ + +T ++A D ++ V ++VLD+
Sbjct: 651 VEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
Query: 2308 NDHAPQFMF---SSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMS 2364
ND+AP +S + P+ + T+ + A DFD+G EL YSI
Sbjct: 709 NDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFDSGVNAELIYSIAG--------G 759
Query: 2365 YDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
+ LF I +G I ++ ++ + + L V+ D+G
Sbjct: 760 NPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Score = 195 bits (496), Expect = 5e-49
Identities = 171/584 (29%), Positives = 268/584 (45%), Gaps = 61/584 (10%)
Query: 1748 LDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNA 1804
LD E + L + + G A+L + D NDN+P FE+ Y+A +SE+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 1805 HVIQVFATDLDSGLNGLIEYSILSGNQ--EEAFQIDALSGVITTKAILDYELTSSYSLIV 1862
VIQV A D D G N IEY+ + ++D +G+IT + +D E S+ V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 1863 QATDKGMPRLSNTTVIKVQVTDINDNAPAFL---------PSEAVEITEDSLPGVIVTHV 1913
A D+G S + V V D+NDNAP I+ED V V
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 1914 SVHDVDL--NSAFI--------FSFAKESNPGT----KFAIDQNTGVVVLVKTLDFEEMT 1959
V D D N+A F + S G+ K+ + T LD+E++
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------PLDYEKVK 470
Query: 1960 EYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
+Y + I DS + + +L V+V+DVNDN PVF+Q +V PE+ G + ++A
Sbjct: 471 DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITA 530
Query: 2017 TDLESNENISYRILSSSKE------FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG 2070
+D +S N + S E F+I P+ G I + L + + + V A+D G
Sbjct: 531 SDADSGSNAEL-VYSLEPEPAAKGLFTISPETGEI-QVKTSLDREQRESYELKVVAADRG 588
Query: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
+P L+ V + + D N+ P+F + YN S+ E+ S + + ID D EN V
Sbjct: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD-KGENAQV 647
Query: 2131 EYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPL 2190
+ S+ N +F ++ G ++ S DRE +++ + A D G PP
Sbjct: 648 QLSVEQDNG--DFVIQNG----------TGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695
Query: 2191 SSTAVISIQVLDVNDNPPNFSSLSYHTH--VKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
S+ ++I VLD NDN P ++ S +H + T LG ++ V+A D D+G +AE+IY+
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755
Query: 2249 IISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEK 2292
I GN G F + ++G + L K ++ L V+ SD K
Sbjct: 756 IAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGK 799
Score = 174 bits (441), Expect = 1e-42
Identities = 162/607 (26%), Positives = 259/607 (42%), Gaps = 73/607 (12%)
Query: 439 LDHETQPVVVLTVQAQLG-SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497
LD E LT++ Q G S P SS + +TV+D NDN P F R S E +S+ +P G
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 498 ALYLARAEDRDSGRNGLIRYSIASPQPGV---FAIDRALGVLFLNGSLGAGEQRELTLTL 554
++ +A D D G N I Y+ V +DR G++ + G + + L ++
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 555 RAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFE------HLVYQVEVSESLSPMT--QML 605
A+D+G +P++A V+ V + +++P+ H +SE ++ T ++
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 606 QTQAHPLGPQRA-----ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
Q G A A + + L + ++ + Y ++ DYE + Y
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY--FLQTTTPLDYEKVKDYTIE 475
Query: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
+ A + + + ++ V+V D NDN+P F V + E+ P VI +ITA D D
Sbjct: 476 IVA-VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 721 SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780
SG N +L+Y + P G F S +
Sbjct: 535 SGSNAELVY---------SLEPEPAAKGL-----------------FTISPE-------- 560
Query: 781 SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 840
GE+ +LDRE R +E+ V+ DRGSP T V V+V D NDN P F
Sbjct: 561 -------TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF- 612
Query: 841 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI 900
L G + V+E P V V D D+G NA+V SV E + F I G I
Sbjct: 613 -MLSG--YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--EQDNGDFVIQNGTGTI 667
Query: 901 RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS--QNIRHLIIP 958
++ + + +Y + A D GVPP V I V+ + ++ N H ++
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLT 727
Query: 959 ENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTS 1018
+ + +S + + D N +L +SI + G F+I S +G + L KE+ E
Sbjct: 728 PQTRLGETVSQVAAED-FDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI--ERRH 784
Query: 1019 HYLFRVI 1025
H L R++
Sbjct: 785 HGLHRLV 791
Score = 171 bits (433), Expect = 1e-41
Identities = 197/807 (24%), Positives = 331/807 (41%), Gaps = 100/807 (12%)
Query: 372 LAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKF-SIHPRL 430
LAP+ + + V E+ P ++ IG++ A + P + ++G + + +
Sbjct: 50 LAPSPGHATRVVYKVPEEQPPNTLIGSLAA----DYGFPDVGHLYKLEVGAPYLRVDGKT 105
Query: 431 GTI-RTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNIT----------------VMDV 473
G I T +D E + Q QL P EV+IT V D+
Sbjct: 106 GDIFTTETSIDREG----LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI 161
Query: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-ASPQ-PGVFAI-- 529
NDN P F + I + T G+ + A DRD+G NG+ Y + A P+ +F +
Sbjct: 162 NDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQV 221
Query: 530 ----DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWT 584
+ L + G+L LT++ +D G P+A+ +L V V++ +++P
Sbjct: 222 AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPK-- 279
Query: 585 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE--PSVDSAMFGIRPYTGW 642
FE Y+ E+SE+ ++Q +A+ Q A + + Y+ P V + + TG
Sbjct: 280 FERPSYEAELSENSPIGHSVIQVKAND-SDQGANAEIEYTFHQAPEVVRRLLRLDRNTGL 338
Query: 643 IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF--------LH 694
I ++ D E T F V A ++ V+V V D NDN+PT H
Sbjct: 339 ITVQGPVDREDLSTLRFSVLA-KDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGPAGTIYVI 753
+ E + + + D D G+N + + D F + TG
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETG-------- 449
Query: 754 TWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD 813
SD + + L++ LD E + + ++ D
Sbjct: 450 -----------------SDSKKKYFLQTT------------TPLDYEKVKDYTIEIVAVD 480
Query: 814 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 873
G+PP ++T ++ V V D+NDN P F Q + V E ++ + A D D G
Sbjct: 481 SGNPPLSSTNSLKVQVVDVNDNAPVFTQSV----TEVAFPENNKPGEVIAEITASDADSG 536
Query: 874 NNAEVTYSVSSEDSSDH-FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQA 932
+NAE+ YS+ E ++ F I GEI+ T L + R SY + V+A D+G P LQG A
Sbjct: 537 SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
Query: 933 VVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD 992
V + V+ + + + + EN+ + ++ D + N ++ S+ D
Sbjct: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDG-DKGENAQVQLSVEQD- 654
Query: 993 KDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052
+G F I + TG + S D E S Y F++ D S+ V ++I+V D+ND++
Sbjct: 655 -NGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNA 712
Query: 1053 P--SFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
P + + +G V A+D D S +N+ + Y I NP F I
Sbjct: 713 PYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELIYSIAGGNP-YGLFQIGSH 770
Query: 1111 FGTLVTVSRLDRESIPTVILTVTASDQ 1137
G + ++R L V SD+
Sbjct: 771 SGAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 164 bits (414), Expect = 2e-39
Identities = 145/563 (25%), Positives = 246/563 (43%), Gaps = 48/563 (8%)
Query: 2001 VPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTT 2060
VPE P + +L+A + Y++ + +D K G IFT + + +
Sbjct: 64 VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123
Query: 2061 Q-----------FLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
Q F V +D L +I ++D+N+ P F L++ E+ +
Sbjct: 124 QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI 183
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
GS D D N Y + +G +Q F ++ +E ++ L+++ +L
Sbjct: 184 GSLFPIPLASDRD-AGPNGVASYELQAGPEAQELFGLQV----AEDQEEKQPQLIVMGNL 238
Query: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH 2228
DRE S++L I D G PP +S+A++ + VLD NDN P F SY + E++P+G
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 2229 ITVVSANDRDTGSHAEIIYNIISGNE--KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
+ V AND D G++AEI Y E + L+ NTG++ + P+D E ++ +V
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL 358
Query: 2287 ASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI--------VPENLPISSTICSIN 2337
A D + A V V+V D ND+AP + + E++ + + +
Sbjct: 359 AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQ 418
Query: 2338 ALDFDAGPYGELTYSIVS--PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCL 2395
D D G +T + P L D + LDYE Y +
Sbjct: 419 VSDRDEGENAAVTCVVAGDVPFQLRQASETGSD----SKKKYFLQTTTPLDYEKVKDYTI 474
Query: 2396 TVQAKDKGDATASLV--VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
+ A D G+ S + V + +++ P+FTQ PE NK ++I + ASDAD
Sbjct: 475 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 2454 AGIDGVILYSL---GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKE--DTLEMKIIAHSP 2508
+G + ++YSL + F+++ G I +K+ L++E ++ E+K++A
Sbjct: 535 SGSNAELVYSLEPEPAAKGLFTISPETGEIQ-------VKTSLDREQRESYELKVVAADR 587
Query: 2509 KSDSKFASCTVFVNVSFSSEGTP 2531
S S + TV VNV ++ P
Sbjct: 588 GSPSLQGTATVLVNVLDCNDNDP 610
Score = 158 bits (400), Expect = 7e-38
Identities = 163/668 (24%), Positives = 270/668 (40%), Gaps = 78/668 (11%)
Query: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP 404
L + QDGG +A + + + T +FERP Y + E+ P + VKA +
Sbjct: 248 LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307
Query: 405 ---LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPA 460
N+ + + + + G I + P+D E + +V A+ G+ P
Sbjct: 308 DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367
Query: 461 CSSTEVNITVMDVNDNHPAF------LRTSDE--IRISQTTPPGTALYLARAEDRDSGRN 512
+ +V +TV D+NDN P L T + IS+ TA+ L + DRD G N
Sbjct: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 513 GLIRYSIASPQPGVFAIDRALG-------VLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 565
+ +A P G L L + ++ T+ + A D G P +
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS 487
Query: 566 ALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
+ L V V++ +++P F V +V E+ P + + A A L YS
Sbjct: 488 STNSLKVQVVDVNDNAP--VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE-LVYS 544
Query: 625 LEPS-VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
LEP +F I P TG I ++ D E ++Y +V A LQ +T V+V V
Sbjct: 545 LEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT-VLVNVL 603
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-GKFFKMNP 742
D NDN P F+ V E+ +G +T ID D G+N Q+ + D G F N
Sbjct: 604 DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQN- 662
Query: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
G G +++ ++ DRE +
Sbjct: 663 --------------------------------------------GTGTILSSLSFDREQQ 678
Query: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
+ + D G PPR+A + V ++V D NDN P+ P H + + V
Sbjct: 679 STYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI--TAPSNTSHKLLTPQTRLGETV 736
Query: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
+ V A+D D G NAE+ YS++ + F+I +++G I + + +R+ V +D
Sbjct: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Query: 923 QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
+G PP G A+V++ V R ++ + H +L + + ++ + G
Sbjct: 797 RGKPPRYGTALVHLYVNETLANRTLLETLLGH-----SLDTPLDIDIAGDPEYERSKQRG 851
Query: 983 KLHFSIVA 990
+ F +VA
Sbjct: 852 NILFGVVA 859
Score = 135 bits (340), Expect = 6e-31
Identities = 194/824 (23%), Positives = 318/824 (38%), Gaps = 161/824 (19%)
Query: 89 YGFIEYS-LYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDRER----------DPATYDLL 136
YGF + LY L AP R+D G I ++ IDRE DP +
Sbjct: 81 YGFPDVGHLYK--LEVGAPY-LRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFE 137
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
V D LV+ G +++++D+NDN P F +I + T G+
Sbjct: 138 VSITD----------LVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLF 187
Query: 197 INVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
LA+D+D+G G +YEL G LF + + +++ N D+E +S
Sbjct: 188 PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL--DRERWDS 245
Query: 256 LEMFLP-------------LLR--------HFKKVERDEEAAEKKFEASRGWFMRFKGRR 294
++ + LLR + K ER AE + G
Sbjct: 246 YDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIG--------H 297
Query: 295 HLHYLKVQDEAASADGEA------AARYVANLAKI-LGEGIIYLTLPLSHLESTTLSLMV 347
+ +K D A+ E A V L ++ G+I + P+ + +TL V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY--------EDVPEDSPIGTV 399
A+D G A V + + E + + EDV E++ + V
Sbjct: 358 LAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV 417
Query: 400 KAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT-------IRTRKPLDHE-TQPVVVLTV 451
+ + + +GD+ + G+ ++T PLD+E + + V
Sbjct: 418 QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIV 477
Query: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
G+ P S+ + + V+DVNDN P F ++ E+ + PG + A D DSG
Sbjct: 478 AVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGS 537
Query: 512 NGLIRYSIASPQP---GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAAL 567
N + YS+ P+P G+F I G + + SL ++ L + A D+G Q
Sbjct: 538 NAELVYSL-EPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTA 596
Query: 568 LVLTVVIEKREHSPSWTFEHLVYQV-EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 626
VL V++ ++ P + + V E +LSP+ + G + + ++ S+E
Sbjct: 597 TVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID----GDKGENAQVQLSVE 652
Query: 627 PSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVIVRVWD 684
D+ F I+ TG I FD E TY F++ A DG + ++ V + V D
Sbjct: 653 Q--DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKA---VDGGVPPRSAYVGVTINVLD 707
Query: 685 ENDNSPTFL------HDVLFLKVEESPVPQGVIG----KITAIDMDSGKNGQLLYFLLSD 734
ENDN+P H +L PQ +G ++ A D DSG N +L+Y +
Sbjct: 708 ENDNAPYITAPSNTSHKLL--------TPQTRLGETVSQVAAEDFDSGVNAELIYSIAGG 759
Query: 735 GKF--FKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELI 792
+ F++ ++G A L+
Sbjct: 760 NPYGLFQIGSHSG------------------------------AITLEK----------- 778
Query: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
++R H G H + V V+DRG PPR T V++ V + NR
Sbjct: 779 ---EIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANR 819
Score = 107 bits (267), Expect = 2e-22
Identities = 164/719 (22%), Positives = 276/719 (38%), Gaps = 162/719 (22%)
Query: 27 DACVYEVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEEN----AKPV------KE 76
D C+ E V I +V++ GSP L G I + +N A PV +
Sbjct: 130 DPCILEFEVSITDLVQN--------GSPRL-LEGQIEVQDINDNTPNFASPVITLAIPEN 180
Query: 77 TEV-------TASDADSGLYGFIEYSLYDGFLSYEAPQAFRI------DPHDGQICVSQD 123
T + ASD D+G G Y L G EA + F + + Q+ V +
Sbjct: 181 TNIGSLFPIPLASDRDAGPNGVASYELQAG---PEAQELFGLQVAEDQEEKQPQLIVMGN 237
Query: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
+DRER + YDL ++ +DG ++ A +RV + D NDN P F +Y
Sbjct: 238 LDRERWDS-YDLTIKVQDGGSPPR----------ASSALLRVTVLDTNDNAPKFERPSYE 286
Query: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGLYSPEVEIL 241
+S+ + G +I V A D D G + Y P V L +D TGL +
Sbjct: 287 AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLIT------ 340
Query: 242 SAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKV 301
V D+E +++L F + +D K A + V
Sbjct: 341 --VQGPVDREDLSTL--------RFSVLAKDRGTNPKSARAQ-------------VVVTV 377
Query: 302 QDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHL-----ESTTLSLM-VSAQDGG-- 353
+D +A +I G G++ ++++ E T ++L+ VS +D G
Sbjct: 378 KDMNDNAP----------TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 354 -GLTAVINADVTIHI--------------FQTTLAPAEFERPK-YTFLVYE--------- 388
+T V+ DV + F T P ++E+ K YT +
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLS 487
Query: 389 ----------DVPEDSPIGTVKAREPL----NSSEPIFYRISSGDLG------------- 421
DV +++P+ T E N + I++ D
Sbjct: 488 STNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEP 547
Query: 422 -----GKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVND 475
G F+I P G I+ + LD E + L V A +P+ T V + V+D ND
Sbjct: 548 EPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCND 607
Query: 476 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV 535
N P F+ + + + P + + + D D G N ++ S+ G F I G
Sbjct: 608 NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN-GDFVIQNGTGT 666
Query: 536 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEV 594
+ + S +Q T L+A D GV P++A + +T+ V+++ +++P T
Sbjct: 667 ILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH--- 723
Query: 595 SESLSPMTQMLQTQAHPLG---PQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 650
+ L+P T++ +T + + L YS+ +F I ++G I L ++ +
Sbjct: 724 -KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 260 bits (664), Expect = 2e-68
Identities = 201/649 (30%), Positives = 311/649 (47%), Gaps = 39/649 (6%)
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEI-DSSTGD----LFL 1008
++ IPEN + ++D +NG H+ ++ +I ++ G+ L +
Sbjct: 148 NISIPENTLINSRFPIPSATDP-DTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIV 206
Query: 1009 SKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENV 1068
+ LD E Y+ ++ D SST L + V D ND+ P F++ + + + EN
Sbjct: 207 QQNLDREQKDTYVMKIKVEDGGTPQK-SSTAILQVTVSDVNDNRPVFKEGQVEVHIPENA 265
Query: 1069 PIGTLVYVFNAKDDD-GSFLNSRIQYYIESH-NPGTNPFLIHPSFGTLVTVSR-LDRESI 1125
P+GT V +A D D GS N+ I+Y + P T + L+TV R LDRE
Sbjct: 266 PVGTSVIQLHATDADIGS--NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 1126 PTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT----FISFP---NAHVKEDVT 1178
+TV ASD + T I + DVND+ P +I P ++ E
Sbjct: 324 AIHKVTVLASDGSSTPA-----RATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1179 VGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD---ESSGLLTTTCPLDYEMKTQH 1235
V + + IT D D NGKV I + F L ++ LL T+ LDYE +
Sbjct: 379 VNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1236 ILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALD 1295
++A D G P+L+ + + V + D ND P+F Q + E SV EN G ++T + A D
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATD 495
Query: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
DSG N+ + +++ P ASF F+++ TG + + + DRE QE F V RD G P L
Sbjct: 496 EDSGKNADIVYQLGPNASF--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQ 553
Query: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIID 1414
S ++ TV DEND++P+F + + V EN + V + +D DAG N+AV I++
Sbjct: 554 SQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILN 613
Query: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDH 1474
N + F ++ SG + + + DREQ S++T + +D G PPRSS + + V+D ND+
Sbjct: 614 DNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDN 671
Query: 1475 SP---SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPM 1530
SP S P+ V A G+VV + AVD D G+N + +Y ++ G F IDP+
Sbjct: 672 SPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDN 1579
+G + H D S T V++ +YV D N
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 244 bits (624), Expect = 7e-64
Identities = 186/635 (29%), Positives = 306/635 (48%), Gaps = 53/635 (8%)
Query: 1772 KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ 1831
K+ ++++D NDN+P F + S+ E+ L N+ ATD D+G NG+ Y +L+G
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-- 184
Query: 1832 EEAFQIDALSGV-------ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
+ F +D + + + LD E +Y + ++ D G P+ S+T +++V V+D
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Query: 1885 INDNAPAFLPSEA-VEITEDSLPG--VIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FA 1939
+NDN P F + V I E++ G VI H + D+ N+ + F + P TK FA
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 1940 IDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPP------VF 1992
++ TG++ + ++LD EE +++ + SD A V + V DVNDNPP +
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 1993 SQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR-ILSSSKEFSIDPKNGTIFTISPV 2051
S V + E PV + ++ +D +++ N + F + + +
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 424
Query: 2052 LLLDTISTTQFL--VEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
LLD T +F + ASD G P L LV + +ED N+ P F LS+SE+
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
G L T S D D + +N + Y + G + + F ++ K G L D
Sbjct: 485 GLYLTTISATDED-SGKNADIVYQL--GPNASFFDLDRK----------TGVLTASRVFD 531
Query: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI 2229
RE + A D+G PPL S A + + VLD NDN P F+ + V E+ P S +
Sbjct: 532 REEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV 591
Query: 2230 TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289
V++ D D G + + +I++ N+ +F L+ +GV+ D E+ + +T V+A+D
Sbjct: 592 GVITVTDADAGENKAVTLSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 2290 -AEKKHFSFAVVFVSVLDDNDHAPQFMF----SSFSCIVPENLPISSTICSINALDFDAG 2344
+ S A V ++V+D ND++P + +SF +VP + S + + A+D D G
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVDTG 708
Query: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDI 2379
EL Y+IVS + LF IDP+TG+I
Sbjct: 709 MNAELKYTIVS--------GNNKGLFRIDPVTGNI 735
Score = 243 bits (619), Expect = 3e-63
Identities = 213/722 (29%), Positives = 316/722 (43%), Gaps = 61/722 (8%)
Query: 1066 ENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFL-IHPSFGTLVTVS-RLDRE 1123
ENVPIG + N + + S Y G P + + S G + T S R+DRE
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 1124 SIPTVILTVTASD-----QAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDV 1177
+ ++ + V + + R + +I++ D ND+ P F S N + E+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENT 155
Query: 1178 TVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD-------ESSGLLTTTCPLDYE 1230
+ S +A DPD G NG Y +L+G F LD E L LD E
Sbjct: 156 LINSRFPIPSATDPDTGFNGVQHYELLNGQS--VFGLDIVETPEGEKWPQLIVQQNLDRE 213
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
K +++ + D GTP SS+ L VTV DVND PVFK+ E + EN G V +
Sbjct: 214 QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273
Query: 1291 VEALDRDSGVNSKLQF----EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLV 1346
+ A D D G N+++++ ++ P A+ LF +N+ TG + LDRE + + VL
Sbjct: 274 LHATDADIGSNAEIRYIFGAQVAP-ATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332
Query: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
DG +T TI V D ND+ P I Y I + TV S+ D N +
Sbjct: 333 SDGSSTPARATVTI--NVTDVNDNPPN-IDLRYIISPING-------TVYLSEKDPVNTK 382
Query: 1407 AVEYHIIDGNTDE-----CFTINEMSGE----------LSTTRALDREQISNFTLVILCS 1451
+ D +TD CF E+ L T+ LD E F+ I+ S
Sbjct: 383 IALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
Query: 1452 DLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNG 1511
D G P + ++V++ D ND+ P F + SV E+ G + +SA D+D G N
Sbjct: 443 DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502
Query: 1512 QTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKV 1571
Y L AS F +D +G L S DRE + + F+ ARD +S +I V
Sbjct: 503 DIVYQLGPNAS-FFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVI-V 560
Query: 1572 YVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSI 1631
V D NDN P N F F+S P T ++ D D G N V S F +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVL 620
Query: 1632 DKYTG----EIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM----EGEDVKIS 1683
D Y+G + F + S Y +K TD G P R++T + I++ + V IS
Sbjct: 621 DPYSGVIKSNVSFDREQQSSY---TFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677
Query: 1684 FSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
+ LV + G+ + V A D+ + +KY+I SGN G+ + +G +T+
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Query: 1743 KE 1744
+E
Sbjct: 738 EE 739
Score = 241 bits (614), Expect = 1e-62
Identities = 194/657 (29%), Positives = 313/657 (47%), Gaps = 39/657 (5%)
Query: 1041 LSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNP 1100
+ I V+D ND++P F +I IS+ EN I + + +A D D F + +Q+Y E N
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGF--NGVQHY-ELLN- 183
Query: 1101 GTNPFLIH-------PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
G + F + + L+ LDRE T ++ + D T ++ + Q+
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAILQV 240
Query: 1154 VILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNEN 1209
+ DVND+ P F H+ E+ VG+ V + A D D G N ++ Y + ++
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 1210 MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD-DGTPALSSSQTLTVTVLDVNDEAPV 1268
F L+ ++GL+T LD E H +TVLA D TPA + T+T+ V DVND P
Sbjct: 301 RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARA---TVTINVTDVNDNPPN 357
Query: 1269 FKQHLYEASV------KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSD 1322
+ + E + + D+D+ VN K+ I F L + +
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417
Query: 1323 TGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIE 1382
+ T+++LD E + F+ +++ D G PSL+ T + +EDEND+ P F ++
Sbjct: 418 QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELS 477
Query: 1383 VLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQI 1441
V EN + + T+ A+D D+G N + Y + G F ++ +G L+ +R DRE+
Sbjct: 478 VSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQ 535
Query: 1442 SNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLS 1501
F + D G PP S + V VLD ND+SP F ++Q V E+ + V V++
Sbjct: 536 ERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 1502 AVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
D D G N + ++ + F +DP SG +K++ + DRE +S +TF A D Q
Sbjct: 596 VTDADAGENKAVTLSILND-NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG-QP 653
Query: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVF--LSPESPTNQTTVI-VRADDLDLGPNGTV 1618
RS+T + + V DVNDN PV+ P + L P S + V V A D+D G N +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1619 VFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLV 1672
++ + +F ID TG I ++ P+ + L + ++D G P T +LV
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
Score = 224 bits (571), Expect = 1e-57
Identities = 207/723 (28%), Positives = 330/723 (45%), Gaps = 75/723 (10%)
Query: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
+P D F + + +IV+ D NDN+P F V+ + + E+ + +A D D+G N
Sbjct: 118 LPND-FFRLIKIKIIVK--DTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFN 174
Query: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784
G Y LL+ F ++ P G W
Sbjct: 175 GVQHYELLNGQSVFGLDIVETPEGE----KWP---------------------------- 202
Query: 785 ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844
+LI LDRE + + M + V D G+P +++T + V+V+D+NDNRP F +
Sbjct: 203 -----QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKE--- 254
Query: 845 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE---DSSDHFKIDANNGEIR 901
++ V + E PV V + A D D G+NAE+ Y ++ + F ++ G I
Sbjct: 255 -GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLIT 313
Query: 902 TTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI----PLSKGRAIMSQNIRHLII 957
L + ++++V+A+D P + +N+ + P R I+S + +
Sbjct: 314 VQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYL 373
Query: 958 PENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL---SKELDY 1014
E ++LI SD NGK+ I +++ F + + + +L S LDY
Sbjct: 374 SEKDPVNTKIALITVSDK-DTDVNGKV---ICFIEREVPFHLKAVYDNQYLLETSSLLDY 429
Query: 1015 ETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLV 1074
E T + F+++ +D K SL+ T + + +ED+ND+ P F +I +SV EN G +
Sbjct: 430 EGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 1075 YVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTA 1134
+A D+D S N+ I Y + P + F + G L DRE I TVTA
Sbjct: 489 TTISATDED-SGKNADIVYQL---GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTA 544
Query: 1135 SDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPD 1192
D L+S A IV +LD ND++P F + V E++ S V IT D D
Sbjct: 545 RDNGT----PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1193 EGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSS 1252
G N VT SIL+ N+N F+LD SG++ + D E ++ + V A D G P SS+
Sbjct: 601 AGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1253 QTLTVTVLDVNDEAPVFKQHLYEASVK---ENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
+T+ V+DVND +PV S K + PG V V A+D D+G+N++L++ I+
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 1310 PGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDEN 1368
G + LF I+ TG + + L V + D G+P SL + + V D
Sbjct: 719 SGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTA 778
Query: 1369 DHA 1371
+A
Sbjct: 779 GNA 781
Score = 217 bits (552), Expect = 2e-55
Identities = 191/644 (29%), Positives = 297/644 (46%), Gaps = 73/644 (11%)
Query: 1878 IKVQVTDINDNAPAFLPSEAVEIT--EDSLPGVIVTHVSVHDVD-----------LNSAF 1924
IK+ V D NDNAP F PS + I+ E++L S D D LN
Sbjct: 128 IKIIVKDTNDNAPMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 1925 IFSFAKESNP-GTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVV 1980
+F P G K+ +++ + LD E+ Y + I++ D + L V
Sbjct: 187 VFGLDIVETPEGEKWP------QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240
Query: 1981 RVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL-------SSS 2033
V DVNDN PVF + +V +PE+ PVG SV+ L ATD + N R + ++
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 2034 KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPE 2093
+ F+++ G I T+ L + + + V ASDG + RA V I + D+N+ P
Sbjct: 301 RLFALNNTTGLI-TVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPN 357
Query: 2094 FTVKSYNLS-------LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146
++ Y +S LSE V + + + D D T V +I F
Sbjct: 358 IDLR-YIISPINGTVYLSEKDPVNTKIALITVSDKD-----TDVNGKVIC------FIER 405
Query: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206
FH + Y L LD E + I+ASDSG P L+ TA++ +++ D NDN
Sbjct: 406 EVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
Query: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGV 2266
PP F+ V E+ G ++T +SA D D+G +A+I+Y + G F L+ TGV
Sbjct: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523
Query: 2267 LYLIKPLDYEKMTKFTLTVQASDAEKKHF-SFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325
L + D E+ +F TV A D S A V V+VLD+ND++P+F + F V E
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 2326 NLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQIL 2385
NLP ST+ I D DAG +T SI++ D+D F++DP +G I +
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILN----------DNDNFVLDPYSGVIKSNVSF 633
Query: 2386 DYENGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIF---TQDQYFFTLPEKNKD 2440
D E + Y V+A D G +++ V +++ +++ P+ + F +P
Sbjct: 634 DREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP 693
Query: 2441 RQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
++ V A D D G++ + Y++ G + F ++ GNI L
Sbjct: 694 GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 203 bits (516), Expect = 2e-51
Identities = 185/590 (31%), Positives = 281/590 (47%), Gaps = 44/590 (7%)
Query: 1748 LDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNA 1804
LD E ++ + + E G A+L + D NDN P F++ + + E+
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 1805 HVIQVFATDLDSGLNGLIEYSI---LSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861
VIQ+ ATD D G N I Y ++ + F ++ +G+IT + LD E T+ + +
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAP------AFLPSEAVEITEDSLP---GVIVTH 1912
V A+D G + TV + VTD+NDN P P + P + +
Sbjct: 330 VLASD-GSSTPARATVT-INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALIT 387
Query: 1913 VSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-- 1970
VS D D+N I F + P A+ N ++ LD+E E+ I SDS
Sbjct: 388 VSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Query: 1971 VHYTEGALV-VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISY 2027
+ ALV V++ D NDNPP+F+Q +++V E+ G + T+SATD +S +N I Y
Sbjct: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 2028 RILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDM 2087
++ ++ F +D K G + T S V + F V A D G P L++ V + + D
Sbjct: 507 QLGPNASFFDLDRKTG-VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 2088 NNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
N+ +P+FT + +SE+ ST+ + D D EN V SI++ N +NF ++
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD-AGENKAVTLSILNDN--DNFVLD- 621
Query: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
PY G + S DRE +S+ + A+D G PP SSTA ++I V+DVNDN
Sbjct: 622 -------PYS--GVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Query: 2208 PNFSSLSYHTHVKESTPL----GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
P S +T K PL GS + V A D DTG +AE+ Y I+SGN KG F ++
Sbjct: 673 PVVISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDA--EKKHFSFAVVFVSVLDDNDHA 2311
TG + L + + L V SD K + +VF+ V D +A
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA 781
Score = 201 bits (511), Expect = 9e-51
Identities = 198/770 (25%), Positives = 328/770 (42%), Gaps = 65/770 (8%)
Query: 1403 GNNRAVEYHIIDGNTDECFT-INEMSGELSTT-RALDREQIS-------------NFTLV 1447
G + ++ Y ++ D ++ +GE+ TT +DRE++ +V
Sbjct: 57 GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVV 116
Query: 1448 ILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDE 1507
IL +D +I +++ V D ND++P FP+ S+ E+ + + + SA D D
Sbjct: 117 ILPNDF-----FRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDT 171
Query: 1508 GLNGQTEYFLTDEAS--GAFTIDPMSGT----LKTSNTLDREARSQHTFSAVARDCSIQG 1561
G NG Y L + S G ++ G L LDRE + + D
Sbjct: 172 GFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP- 230
Query: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFS 1621
+S+T I++V V+DVNDN PV ++ +V + +P + + + A D D+G N + +
Sbjct: 231 QKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYI 290
Query: 1622 FA-----ETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQG--IPARTTTGLLVIH 1674
F T+ +F+++ TG I Q++ E I + G PAR T + V
Sbjct: 291 FGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTD 350
Query: 1675 MEGEDVKISFSHHL--YKGLV--TENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGV 1730
+ I + + G V +E T I + D+ + K F E
Sbjct: 351 VNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG-KVICFIEREVPF 409
Query: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA---VLIQDENDNSPCF 1787
Q ++ LD+E E ++A SG + + A V ++DENDN P F
Sbjct: 410 HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Q + + SVSE+ ++ + ATD DSG N I Y + G F +D +GV+T
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
+ D E + V A D G P L + + V V D NDN+P F + ++LP
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 1907 --GVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELL 1964
V V V+ D N A S N F +D +GV+ + D E+ + Y
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSIL---NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFD 644
Query: 1965 IQISDS---VHYTEGALVVRVLDVNDNPPVF----SQDFYQVTVPESIPVGYSVLTLSAT 2017
++ +D + + + V+DVNDN PV S +++ +IP G V + A
Sbjct: 645 VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAV 703
Query: 2018 DLES--NENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP- 2072
D+++ N + Y I+S + + F IDP G I T+ + + +V SD G P
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPK 762
Query: 2073 DLRALTLVEIGIED-MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDH 2121
L L LV + + D N + + + + D +G + + N D+
Sbjct: 763 SLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDY 812
Score = 197 bits (500), Expect = 2e-49
Identities = 179/676 (26%), Positives = 298/676 (44%), Gaps = 36/676 (5%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 884
+ + V D NDN P FP + +++ + E +N A DPD G N Y + +
Sbjct: 128 IKIIVKDTNDNAPMFPSPV----INISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN 183
Query: 885 EDSSDHFKI-DANNGEIRTTTI----LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI 939
S I + GE I L + + +Y M + D G P A++ + V
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
Query: 940 PLSKGRAIMSQNIRHLIIPENLK-PTKIMSLIKSSDHLQQHYNGKLHFSI-VADDKDGHF 997
++ R + + + IPEN T ++ L + + + + F VA F
Sbjct: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 998 EIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD 1057
++++TG + + + LD E T+ + V+ +D S S + ++I+V D ND+ P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGS---STPARATVTINVTDVNDNPPNIDL 360
Query: 1058 ELIV------ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
I+ + + E P+ T + + D D + +N ++ +IE P + ++ +
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKD-TDVNGKVICFIEREVP-FHLKAVYDNQ 418
Query: 1112 GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPN 1170
L T S LD E + ASD + ++ ++ + D ND+ P F
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLN---QTALVRVKLEDENDNPPIFNQPVIE 475
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
V E+ G + I+A D D G+N + Y + G F LD +G+LT + D E
Sbjct: 476 LSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDRE 533
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ + I TV A D+GTP L S + VTVLD ND +P F + ++ V EN V
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
+ D D+G N + I+ + F ++ +G + + DRE Q +T V DGG
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIV----SSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
P SST + V D ND++P I +S+ + L VV V A D+D G N
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQV 1466
++Y I+ GN F I+ ++G ++ + LV+ SDLG P S+ L +
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYP--KSLHTLVL 769
Query: 1467 RVLDANDHSPSFPTLY 1482
L ND + + +Y
Sbjct: 770 VFLYVNDTAGNASYIY 785
Score = 154 bits (390), Expect = 9e-37
Identities = 184/727 (25%), Positives = 292/727 (40%), Gaps = 108/727 (14%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
++ I V D NDN P F I I + T + + A D D+G NG+ Y + + Q
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ- 185
Query: 525 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EK 576
VF +D L + +L ++ + ++ ED G +++ +L V + +
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA---M 633
++ P F+ +V + E+ T ++Q A A +RY V A +
Sbjct: 246 NDNRP--VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAE-IRYIFGAQVAPATKRL 302
Query: 634 FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF- 692
F + TG I ++R D E T + V A DG TV + V D NDN P
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLA---SDGSSTPARATVTINVTDVNDNPPNID 359
Query: 693 -------LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTG 745
++ ++L E+ PV I IT D D+ NG+++ F+ + F
Sbjct: 360 LRYIISPINGTVYLS-EKDPV-NTKIALITVSDKDTDVNGKVICFIEREVPF-------- 409
Query: 746 PAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHH 805
L+A E LD E
Sbjct: 410 ---------------------------HLKAVYDNQYLLETSS-------LLDYEGTKEF 435
Query: 806 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 865
++ +D G P N T V V + D NDN P F Q + + + V E + +TT+
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPV----IELSVSENNRRGLYLTTI 491
Query: 866 FAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGV 925
A D D G NA++ Y + ++ F +D G + + + + + + +V A D G
Sbjct: 492 SATDEDSGKNADIVYQLG--PNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGT 549
Query: 926 PPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLH 985
PPLQ QA V + V+ + + N + ENL + +I +D N +
Sbjct: 550 PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD-ADAGENKAVT 608
Query: 986 FSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDV 1045
SI+ D + +F +D +G + + D E S Y F V TD + SST ++I+V
Sbjct: 609 LSILND--NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-PRSSTAKVTINV 665
Query: 1046 EDQNDHSPSFQDELIVISVEEN----------VPIGTLVYVFNAKDDDGSFLNSRIQYYI 1095
D ND+SP +VIS N +P + VF D G +N+ ++Y I
Sbjct: 666 MDVNDNSP------VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG--MNAELKYTI 717
Query: 1096 ESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL-RSL-TAQI 1153
S N F I P G + L+ + PT V VN++D +SL T +
Sbjct: 718 VSGN-NKGLFRIDPVTGNIT----LEEKPAPT---DVGLHRLVVNISDLGYPKSLHTLVL 769
Query: 1154 VILDVND 1160
V L VND
Sbjct: 770 VFLYVND 776
Score = 153 bits (386), Expect = 3e-36
Identities = 130/504 (25%), Positives = 227/504 (45%), Gaps = 41/504 (8%)
Query: 2001 VPESIPVGYSVLTLSATDLES----NENISYRILSSSKE---FSIDPKNGTIFTISPVLL 2053
+PE++P+G L+ + + + + ++ YR++S + + + G IFT S +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
Query: 2054 LDTISTTQFLVEASDGGNP--------DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
+ + E ++ D L ++I ++D N+ AP F N+S+ E
Sbjct: 94 REKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPE 153
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
+ L+ S S D D T N Y +++G S + ++P L++
Sbjct: 154 NTLINSRFPIPSATDPD-TGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQ-----LIVQ 207
Query: 2166 HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
+LDRE ++ + I D G P SSTA++ + V DVNDN P F H+ E+ P+
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
Query: 2226 GSHITVVSANDRDTGSHAEIIYNI---ISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282
G+ + + A D D GS+AEI Y ++ K F L TG++ + + LD E+
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
Query: 2283 LTVQASDAEKKHFSFAVVFVSVLDDNDHAP----QFMFSSFSCIV--PENLPISSTICSI 2336
+TV ASD + A V ++V D ND+ P +++ S + V E P+++ I I
Sbjct: 328 VTVLASDGSSTP-ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALI 386
Query: 2337 NALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLT 2396
D D G++ I YD+ L +LDYE ++
Sbjct: 387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL--------ETSSLLDYEGTKEFSFK 438
Query: 2397 VQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADA 2454
+ A D G + +V V +E ++ PIF Q ++ E N+ + + A+D D+
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 2455 GIDGVILYSLGTSSPFFSVNKTNG 2478
G + I+Y LG ++ FF +++ G
Sbjct: 499 GKNADIVYQLGPNASFFDLDRKTG 522
Score = 133 bits (334), Expect = 3e-30
Identities = 171/643 (26%), Positives = 268/643 (41%), Gaps = 97/643 (15%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NV 221
+++ ++D NDN P+F SI + T + ATD D+G G YEL+ G +V
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 222 SSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFE 281
L +++ G P++ V + D+E ++ M + KVE D +K
Sbjct: 188 FGLDIVETPEGEKWPQL----IVQQNLDREQKDTYVMKI-------KVE-DGGTPQKSST 235
Query: 282 A-----------SRGWFMRFKGRRHLHYLK--------VQDEAASAD--GEAAARY---- 316
A +R F +G+ +H + +Q A AD A RY
Sbjct: 236 AILQVTVSDVNDNRPVFK--EGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293
Query: 317 -VANLAKIL-----GEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 370
VA K L G+I + L E+ + V A DG A A VTI++
Sbjct: 294 QVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDV 351
Query: 371 TLAPAEFERPKYTFLVYEDVPEDSPI-GTV--KAREPLNSSEPIF-YRISSGDLGGKF-- 424
P + +Y SPI GTV ++P+N+ + D+ GK
Sbjct: 352 NDNPPNIDL-RYII---------SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVIC 401
Query: 425 -----------SIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMD 472
+++ + T LD+E + A P+ + T V + + D
Sbjct: 402 FIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLED 461
Query: 473 VNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRA 532
NDN P F + E+ +S+ G L A D DSG+N I Y + P F +DR
Sbjct: 462 ENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLG-PNASFFDLDRK 520
Query: 533 LGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQ 591
GVL + EQ T+ A D G P Q+ V+ V+++ ++SP +T H +Q
Sbjct: 521 TGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH--FQ 578
Query: 592 VEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQF 649
VSE+L + + + G +A + L D+ F + PY+G I F
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVT-----LSILNDNDNFVLDPYSGVIKSNVSF 633
Query: 650 DYESTQTYNFRVFAWIPEDGFLQNVSTT--VIVRVWDENDNSPTFLH---DVLFLKVEES 704
D E +Y F V A DG S+T V + V D NDNSP + + F V S
Sbjct: 634 DREQQSSYTFDVKA---TDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS 690
Query: 705 PVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTG 745
+P V+ ++ A+D+D+G N +L Y ++S F+++P TG
Sbjct: 691 AIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTG 733
Score = 98.2 bits (243), Expect = 1e-19
Identities = 175/789 (22%), Positives = 309/789 (39%), Gaps = 160/789 (20%)
Query: 7 TKSENEDGEKKMFTQQFESTDACVYEVYV-----------KINSIVKSQSQCGLKRGSPE 55
T S D EK + + C +E+ V KI IVK + SP
Sbjct: 87 TTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPV 146
Query: 56 TELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSY-----EAPQAFR 110
+ +I + + P+ +A+D D+G G Y L +G + E P+ +
Sbjct: 147 INI--SIPENTLINSRFPIP----SATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200
Query: 111 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDV 170
Q+ V Q++DRE+ TY + ++ +DG + S+ A ++V + DV
Sbjct: 201 WP----QLIVQQNLDREQKD-TYVMKIKVEDGGTPQK----------SSTAILQVTVSDV 245
Query: 171 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY----ELIPGNVSSLFT 226
NDN PVF I + GT +I + ATD D G + Y ++ P LF
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA-TKRLFA 304
Query: 227 IDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEK-KFEASRG 285
+++TTGL + + + ++R+E A K AS G
Sbjct: 305 LNNTTGLITVQ-----------------------------RSLDREETAIHKVTVLASDG 335
Query: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSL 345
+ ++ V D + D RY+ + G +YL+ + + +
Sbjct: 336 SSTPARATVTINVTDVNDNPPNID----LRYIISPI----NGTVYLS-EKDPVNTKIALI 386
Query: 346 MVSAQD---GGGLTAVINADVTIHI--------FQTTLAPAEFERPK-YTF-LVYEDVPE 392
VS +D G + I +V H+ T + ++E K ++F +V D +
Sbjct: 387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Query: 393 DSPIGTVKAR---EPLNSSEPIFYR---------------------ISSGDLGGKFSIHP 428
S T R E N + PIF + + D G I
Sbjct: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 429 RLGTIRTRKPLDHET-------------QPVVVLTVQAQ-LGSAPACSSTEVNITVMDVN 474
+LG + LD +T Q + TV A+ G+ P S V +TV+D N
Sbjct: 507 QLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566
Query: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALG 534
DN P F + +S+ P + + + D D+G N + SI + F +D G
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN-FVLDPYSG 625
Query: 535 VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE 593
V+ N S +Q T ++A D G P+++ +T+ V++ ++SP V
Sbjct: 626 VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSP----------VV 675
Query: 594 VSESLSPMTQMLQTQAHPLGPQRAA-----------SPLRYSLEPSVDSAMFGIRPYTGW 642
+S + +++ A P G A + L+Y++ + +F I P TG
Sbjct: 676 ISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGN 734
Query: 643 IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSPTFLHDVLFLKV 701
I L + T R+ I + G+ +++ T V+V ++ ++ + ++++D L +
Sbjct: 735 ITLEEK--PAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYD-LIRRT 791
Query: 702 EESPVPQGV 710
E+P+ + +
Sbjct: 792 METPLDRNI 800
Score = 72.8 bits (177), Expect = 5e-12
Identities = 81/343 (23%), Positives = 153/343 (44%), Gaps = 54/343 (15%)
Query: 2221 ESTPLGS-----HITVVSANDRDTGSHAEIIYNIIS-GNEKGHFYLEENTGVLYLIKP-L 2273
E+ P+G+ +I+ ++A TG+ A ++Y ++S + + +TG ++ +
Sbjct: 36 ENVPIGNIPKDLNISHINAA---TGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 2274 DYEKMTKFTLTVQASDAEKKHFSFAV--------------VFVSVLDDNDHAPQFMFSSF 2319
D EK L AS AE+ F + + + V D ND+AP F
Sbjct: 93 DREK-----LCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVI 147
Query: 2320 SCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGD- 2378
+ +PEN I+S +A D D G G Y +++ G S L +++ G+
Sbjct: 148 NISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN------GQSV-FGLDIVETPEGEK 200
Query: 2379 ---IHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFT 2433
+ +Q LD E + Y + ++ +D G +++ ++ V + +++ P+F + Q
Sbjct: 201 WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260
Query: 2434 LPEKNKDRQLIGRVEASDADAGIDGVILYSLGT-----SSPFFSVNKTNGNIYLIRALPL 2488
+PE + ++ A+DAD G + I Y G + F++N T G I + R+L
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL-- 318
Query: 2489 IKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
++E+T K+ + S A TV +NV+ ++ P
Sbjct: 319 -----DREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPP 356
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 260 bits (664), Expect = 2e-68
Identities = 201/649 (30%), Positives = 311/649 (47%), Gaps = 39/649 (6%)
Query: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEI-DSSTGD----LFL 1008
++ IPEN + ++D +NG H+ ++ +I ++ G+ L +
Sbjct: 148 NISIPENTLINSRFPIPSATDP-DTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIV 206
Query: 1009 SKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENV 1068
+ LD E Y+ ++ D SST L + V D ND+ P F++ + + + EN
Sbjct: 207 QQNLDREQKDTYVMKIKVEDGGTPQK-SSTAILQVTVSDVNDNRPVFKEGQVEVHIPENA 265
Query: 1069 PIGTLVYVFNAKDDD-GSFLNSRIQYYIESH-NPGTNPFLIHPSFGTLVTVSR-LDRESI 1125
P+GT V +A D D GS N+ I+Y + P T + L+TV R LDRE
Sbjct: 266 PVGTSVIQLHATDADIGS--NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 1126 PTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT----FISFP---NAHVKEDVT 1178
+TV ASD + T I + DVND+ P +I P ++ E
Sbjct: 324 AIHKVTVLASDGSSTPA-----RATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1179 VGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD---ESSGLLTTTCPLDYEMKTQH 1235
V + + IT D D NGKV I + F L ++ LL T+ LDYE +
Sbjct: 379 VNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1236 ILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALD 1295
++A D G P+L+ + + V + D ND P+F Q + E SV EN G ++T + A D
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATD 495
Query: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
DSG N+ + +++ P ASF F+++ TG + + + DRE QE F V RD G P L
Sbjct: 496 EDSGKNADIVYQLGPNASF--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQ 553
Query: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIID 1414
S ++ TV DEND++P+F + + V EN + V + +D DAG N+AV I++
Sbjct: 554 SQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILN 613
Query: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDH 1474
N + F ++ SG + + + DREQ S++T + +D G PPRSS + + V+D ND+
Sbjct: 614 DNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDN 671
Query: 1475 SP---SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPM 1530
SP S P+ V A G+VV + AVD D G+N + +Y ++ G F IDP+
Sbjct: 672 SPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDN 1579
+G + H D S T V++ +YV D N
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 244 bits (624), Expect = 7e-64
Identities = 186/635 (29%), Positives = 306/635 (48%), Gaps = 53/635 (8%)
Query: 1772 KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ 1831
K+ ++++D NDN+P F + S+ E+ L N+ ATD D+G NG+ Y +L+G
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-- 184
Query: 1832 EEAFQIDALSGV-------ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
+ F +D + + + LD E +Y + ++ D G P+ S+T +++V V+D
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Query: 1885 INDNAPAFLPSEA-VEITEDSLPG--VIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FA 1939
+NDN P F + V I E++ G VI H + D+ N+ + F + P TK FA
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 1940 IDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPP------VF 1992
++ TG++ + ++LD EE +++ + SD A V + V DVNDNPP +
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 1993 SQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR-ILSSSKEFSIDPKNGTIFTISPV 2051
S V + E PV + ++ +D +++ N + F + + +
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 424
Query: 2052 LLLDTISTTQFL--VEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
LLD T +F + ASD G P L LV + +ED N+ P F LS+SE+
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
G L T S D D + +N + Y + G + + F ++ K G L D
Sbjct: 485 GLYLTTISATDED-SGKNADIVYQL--GPNASFFDLDRK----------TGVLTASRVFD 531
Query: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI 2229
RE + A D+G PPL S A + + VLD NDN P F+ + V E+ P S +
Sbjct: 532 REEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV 591
Query: 2230 TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289
V++ D D G + + +I++ N+ +F L+ +GV+ D E+ + +T V+A+D
Sbjct: 592 GVITVTDADAGENKAVTLSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 2290 -AEKKHFSFAVVFVSVLDDNDHAPQFMF----SSFSCIVPENLPISSTICSINALDFDAG 2344
+ S A V ++V+D ND++P + +SF +VP + S + + A+D D G
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVDTG 708
Query: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDI 2379
EL Y+IVS + LF IDP+TG+I
Sbjct: 709 MNAELKYTIVS--------GNNKGLFRIDPVTGNI 735
Score = 243 bits (619), Expect = 3e-63
Identities = 213/722 (29%), Positives = 316/722 (43%), Gaps = 61/722 (8%)
Query: 1066 ENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFL-IHPSFGTLVTVS-RLDRE 1123
ENVPIG + N + + S Y G P + + S G + T S R+DRE
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 1124 SIPTVILTVTASD-----QAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDV 1177
+ ++ + V + + R + +I++ D ND+ P F S N + E+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENT 155
Query: 1178 TVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD-------ESSGLLTTTCPLDYE 1230
+ S +A DPD G NG Y +L+G F LD E L LD E
Sbjct: 156 LINSRFPIPSATDPDTGFNGVQHYELLNGQS--VFGLDIVETPEGEKWPQLIVQQNLDRE 213
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
K +++ + D GTP SS+ L VTV DVND PVFK+ E + EN G V +
Sbjct: 214 QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273
Query: 1291 VEALDRDSGVNSKLQF----EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLV 1346
+ A D D G N+++++ ++ P A+ LF +N+ TG + LDRE + + VL
Sbjct: 274 LHATDADIGSNAEIRYIFGAQVAP-ATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332
Query: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
DG +T TI V D ND+ P I Y I + TV S+ D N +
Sbjct: 333 SDGSSTPARATVTI--NVTDVNDNPPN-IDLRYIISPING-------TVYLSEKDPVNTK 382
Query: 1407 AVEYHIIDGNTDE-----CFTINEMSGE----------LSTTRALDREQISNFTLVILCS 1451
+ D +TD CF E+ L T+ LD E F+ I+ S
Sbjct: 383 IALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442
Query: 1452 DLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNG 1511
D G P + ++V++ D ND+ P F + SV E+ G + +SA D+D G N
Sbjct: 443 DSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNA 502
Query: 1512 QTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKV 1571
Y L AS F +D +G L S DRE + + F+ ARD +S +I V
Sbjct: 503 DIVYQLGPNAS-FFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVI-V 560
Query: 1572 YVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSI 1631
V D NDN P N F F+S P T ++ D D G N V S F +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVL 620
Query: 1632 DKYTG----EIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM----EGEDVKIS 1683
D Y+G + F + S Y +K TD G P R++T + I++ + V IS
Sbjct: 621 DPYSGVIKSNVSFDREQQSSY---TFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677
Query: 1684 FSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
+ LV + G+ + V A D+ + +KY+I SGN G+ + +G +T+
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Query: 1743 KE 1744
+E
Sbjct: 738 EE 739
Score = 241 bits (614), Expect = 1e-62
Identities = 194/657 (29%), Positives = 313/657 (47%), Gaps = 39/657 (5%)
Query: 1041 LSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNP 1100
+ I V+D ND++P F +I IS+ EN I + + +A D D F + +Q+Y E N
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGF--NGVQHY-ELLN- 183
Query: 1101 GTNPFLIH-------PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
G + F + + L+ LDRE T ++ + D T ++ + Q+
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAILQV 240
Query: 1154 VILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNEN 1209
+ DVND+ P F H+ E+ VG+ V + A D D G N ++ Y + ++
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 1210 MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD-DGTPALSSSQTLTVTVLDVNDEAPV 1268
F L+ ++GL+T LD E H +TVLA D TPA + T+T+ V DVND P
Sbjct: 301 RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARA---TVTINVTDVNDNPPN 357
Query: 1269 FKQHLYEASV------KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSD 1322
+ + E + + D+D+ VN K+ I F L + +
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN 417
Query: 1323 TGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIE 1382
+ T+++LD E + F+ +++ D G PSL+ T + +EDEND+ P F ++
Sbjct: 418 QYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELS 477
Query: 1383 VLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQI 1441
V EN + + T+ A+D D+G N + Y + G F ++ +G L+ +R DRE+
Sbjct: 478 VSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQ 535
Query: 1442 SNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLS 1501
F + D G PP S + V VLD ND+SP F ++Q V E+ + V V++
Sbjct: 536 ERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 1502 AVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
D D G N + ++ + F +DP SG +K++ + DRE +S +TF A D Q
Sbjct: 596 VTDADAGENKAVTLSILND-NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG-QP 653
Query: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVF--LSPESPTNQTTVI-VRADDLDLGPNGTV 1618
RS+T + + V DVNDN PV+ P + L P S + V V A D+D G N +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1619 VFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLV 1672
++ + +F ID TG I ++ P+ + L + ++D G P T +LV
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLV 770
Score = 224 bits (571), Expect = 1e-57
Identities = 207/723 (28%), Positives = 330/723 (45%), Gaps = 75/723 (10%)
Query: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
+P D F + + +IV+ D NDN+P F V+ + + E+ + +A D D+G N
Sbjct: 118 LPND-FFRLIKIKIIVK--DTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFN 174
Query: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784
G Y LL+ F ++ P G W
Sbjct: 175 GVQHYELLNGQSVFGLDIVETPEGE----KWP---------------------------- 202
Query: 785 ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844
+LI LDRE + + M + V D G+P +++T + V+V+D+NDNRP F +
Sbjct: 203 -----QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKE--- 254
Query: 845 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE---DSSDHFKIDANNGEIR 901
++ V + E PV V + A D D G+NAE+ Y ++ + F ++ G I
Sbjct: 255 -GQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLIT 313
Query: 902 TTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI----PLSKGRAIMSQNIRHLII 957
L + ++++V+A+D P + +N+ + P R I+S + +
Sbjct: 314 VQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYL 373
Query: 958 PENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL---SKELDY 1014
E ++LI SD NGK+ I +++ F + + + +L S LDY
Sbjct: 374 SEKDPVNTKIALITVSDK-DTDVNGKV---ICFIEREVPFHLKAVYDNQYLLETSSLLDY 429
Query: 1015 ETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLV 1074
E T + F+++ +D K SL+ T + + +ED+ND+ P F +I +SV EN G +
Sbjct: 430 EGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYL 488
Query: 1075 YVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTA 1134
+A D+D S N+ I Y + P + F + G L DRE I TVTA
Sbjct: 489 TTISATDED-SGKNADIVYQL---GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTA 544
Query: 1135 SDQAVNVTDRRLRSLTAQIV-ILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPD 1192
D L+S A IV +LD ND++P F + V E++ S V IT D D
Sbjct: 545 RDNGT----PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1193 EGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSS 1252
G N VT SIL+ N+N F+LD SG++ + D E ++ + V A D G P SS+
Sbjct: 601 AGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1253 QTLTVTVLDVNDEAPVFKQHLYEASVK---ENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
+T+ V+DVND +PV S K + PG V V A+D D+G+N++L++ I+
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 1310 PGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDEN 1368
G + LF I+ TG + + L V + D G+P SL + + V D
Sbjct: 719 SGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTA 778
Query: 1369 DHA 1371
+A
Sbjct: 779 GNA 781
Score = 217 bits (552), Expect = 2e-55
Identities = 191/644 (29%), Positives = 297/644 (46%), Gaps = 73/644 (11%)
Query: 1878 IKVQVTDINDNAPAFLPSEAVEIT--EDSLPGVIVTHVSVHDVD-----------LNSAF 1924
IK+ V D NDNAP F PS + I+ E++L S D D LN
Sbjct: 128 IKIIVKDTNDNAPMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 1925 IFSFAKESNP-GTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVV 1980
+F P G K+ +++ + LD E+ Y + I++ D + L V
Sbjct: 187 VFGLDIVETPEGEKWP------QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV 240
Query: 1981 RVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL-------SSS 2033
V DVNDN PVF + +V +PE+ PVG SV+ L ATD + N R + ++
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 2034 KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPE 2093
+ F+++ G I T+ L + + + V ASDG + RA V I + D+N+ P
Sbjct: 301 RLFALNNTTGLI-TVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPN 357
Query: 2094 FTVKSYNLS-------LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVE 2146
++ Y +S LSE V + + + D D T V +I F
Sbjct: 358 IDLR-YIISPINGTVYLSEKDPVNTKIALITVSDKD-----TDVNGKVIC------FIER 405
Query: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206
FH + Y L LD E + I+ASDSG P L+ TA++ +++ D NDN
Sbjct: 406 EVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
Query: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGV 2266
PP F+ V E+ G ++T +SA D D+G +A+I+Y + G F L+ TGV
Sbjct: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523
Query: 2267 LYLIKPLDYEKMTKFTLTVQASDAEKKHF-SFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325
L + D E+ +F TV A D S A V V+VLD+ND++P+F + F V E
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 2326 NLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQIL 2385
NLP ST+ I D DAG +T SI++ D+D F++DP +G I +
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILN----------DNDNFVLDPYSGVIKSNVSF 633
Query: 2386 DYENGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIF---TQDQYFFTLPEKNKD 2440
D E + Y V+A D G +++ V +++ +++ P+ + F +P
Sbjct: 634 DREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP 693
Query: 2441 RQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
++ V A D D G++ + Y++ G + F ++ GNI L
Sbjct: 694 GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 203 bits (516), Expect = 2e-51
Identities = 185/590 (31%), Positives = 281/590 (47%), Gaps = 44/590 (7%)
Query: 1748 LDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNA 1804
LD E ++ + + E G A+L + D NDN P F++ + + E+
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 1805 HVIQVFATDLDSGLNGLIEYSI---LSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861
VIQ+ ATD D G N I Y ++ + F ++ +G+IT + LD E T+ + +
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAP------AFLPSEAVEITEDSLP---GVIVTH 1912
V A+D G + TV + VTD+NDN P P + P + +
Sbjct: 330 VLASD-GSSTPARATVT-INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALIT 387
Query: 1913 VSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-- 1970
VS D D+N I F + P A+ N ++ LD+E E+ I SDS
Sbjct: 388 VSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Query: 1971 VHYTEGALV-VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISY 2027
+ ALV V++ D NDNPP+F+Q +++V E+ G + T+SATD +S +N I Y
Sbjct: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 2028 RILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDM 2087
++ ++ F +D K G + T S V + F V A D G P L++ V + + D
Sbjct: 507 QLGPNASFFDLDRKTG-VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 2088 NNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVET 2147
N+ +P+FT + +SE+ ST+ + D D EN V SI++ N +NF ++
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD-AGENKAVTLSILNDN--DNFVLD- 621
Query: 2148 KFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
PY G + S DRE +S+ + A+D G PP SSTA ++I V+DVNDN
Sbjct: 622 -------PYS--GVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Query: 2208 PNFSSLSYHTHVKESTPL----GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
P S +T K PL GS + V A D DTG +AE+ Y I+SGN KG F ++
Sbjct: 673 PVVISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDA--EKKHFSFAVVFVSVLDDNDHA 2311
TG + L + + L V SD K + +VF+ V D +A
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA 781
Score = 201 bits (511), Expect = 9e-51
Identities = 198/770 (25%), Positives = 328/770 (42%), Gaps = 65/770 (8%)
Query: 1403 GNNRAVEYHIIDGNTDECFT-INEMSGELSTT-RALDREQIS-------------NFTLV 1447
G + ++ Y ++ D ++ +GE+ TT +DRE++ +V
Sbjct: 57 GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVV 116
Query: 1448 ILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDE 1507
IL +D +I +++ V D ND++P FP+ S+ E+ + + + SA D D
Sbjct: 117 ILPNDF-----FRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDT 171
Query: 1508 GLNGQTEYFLTDEAS--GAFTIDPMSGT----LKTSNTLDREARSQHTFSAVARDCSIQG 1561
G NG Y L + S G ++ G L LDRE + + D
Sbjct: 172 GFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP- 230
Query: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFS 1621
+S+T I++V V+DVNDN PV ++ +V + +P + + + A D D+G N + +
Sbjct: 231 QKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYI 290
Query: 1622 FA-----ETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQG--IPARTTTGLLVIH 1674
F T+ +F+++ TG I Q++ E I + G PAR T + V
Sbjct: 291 FGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTD 350
Query: 1675 MEGEDVKISFSHHL--YKGLV--TENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGV 1730
+ I + + G V +E T I + D+ + K F E
Sbjct: 351 VNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG-KVICFIEREVPF 409
Query: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA---VLIQDENDNSPCF 1787
Q ++ LD+E E ++A SG + + A V ++DENDN P F
Sbjct: 410 HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Q + + SVSE+ ++ + ATD DSG N I Y + G F +D +GV+T
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
+ D E + V A D G P L + + V V D NDN+P F + ++LP
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 1907 --GVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELL 1964
V V V+ D N A S N F +D +GV+ + D E+ + Y
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSIL---NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFD 644
Query: 1965 IQISDS---VHYTEGALVVRVLDVNDNPPVF----SQDFYQVTVPESIPVGYSVLTLSAT 2017
++ +D + + + V+DVNDN PV S +++ +IP G V + A
Sbjct: 645 VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAV 703
Query: 2018 DLES--NENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP- 2072
D+++ N + Y I+S + + F IDP G I T+ + + +V SD G P
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPK 762
Query: 2073 DLRALTLVEIGIED-MNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDH 2121
L L LV + + D N + + + + D +G + + N D+
Sbjct: 763 SLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDY 812
Score = 197 bits (500), Expect = 2e-49
Identities = 179/676 (26%), Positives = 298/676 (44%), Gaps = 36/676 (5%)
Query: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 884
+ + V D NDN P FP + +++ + E +N A DPD G N Y + +
Sbjct: 128 IKIIVKDTNDNAPMFPSPV----INISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN 183
Query: 885 EDSSDHFKI-DANNGEIRTTTI----LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI 939
S I + GE I L + + +Y M + D G P A++ + V
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
Query: 940 PLSKGRAIMSQNIRHLIIPENLK-PTKIMSLIKSSDHLQQHYNGKLHFSI-VADDKDGHF 997
++ R + + + IPEN T ++ L + + + + F VA F
Sbjct: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 998 EIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD 1057
++++TG + + + LD E T+ + V+ +D S S + ++I+V D ND+ P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGS---STPARATVTINVTDVNDNPPNIDL 360
Query: 1058 ELIV------ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
I+ + + E P+ T + + D D + +N ++ +IE P + ++ +
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKD-TDVNGKVICFIEREVP-FHLKAVYDNQ 418
Query: 1112 GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPN 1170
L T S LD E + ASD + ++ ++ + D ND+ P F
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLN---QTALVRVKLEDENDNPPIFNQPVIE 475
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
V E+ G + I+A D D G+N + Y + G F LD +G+LT + D E
Sbjct: 476 LSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDRE 533
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ + I TV A D+GTP L S + VTVLD ND +P F + ++ V EN V
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
+ D D+G N + I+ + F ++ +G + + DRE Q +T V DGG
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIV----SSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
P SST + V D ND++P I +S+ + L VV V A D+D G N
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQV 1466
++Y I+ GN F I+ ++G ++ + LV+ SDLG P S+ L +
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYP--KSLHTLVL 769
Query: 1467 RVLDANDHSPSFPTLY 1482
L ND + + +Y
Sbjct: 770 VFLYVNDTAGNASYIY 785
Score = 154 bits (390), Expect = 9e-37
Identities = 184/727 (25%), Positives = 292/727 (40%), Gaps = 108/727 (14%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
++ I V D NDN P F I I + T + + A D D+G NG+ Y + + Q
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ- 185
Query: 525 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EK 576
VF +D L + +L ++ + ++ ED G +++ +L V + +
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA---M 633
++ P F+ +V + E+ T ++Q A A +RY V A +
Sbjct: 246 NDNRP--VFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAE-IRYIFGAQVAPATKRL 302
Query: 634 FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF- 692
F + TG I ++R D E T + V A DG TV + V D NDN P
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLA---SDGSSTPARATVTINVTDVNDNPPNID 359
Query: 693 -------LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTG 745
++ ++L E+ PV I IT D D+ NG+++ F+ + F
Sbjct: 360 LRYIISPINGTVYLS-EKDPV-NTKIALITVSDKDTDVNGKVICFIEREVPF-------- 409
Query: 746 PAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHH 805
L+A E LD E
Sbjct: 410 ---------------------------HLKAVYDNQYLLETSS-------LLDYEGTKEF 435
Query: 806 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 865
++ +D G P N T V V + D NDN P F Q + + + V E + +TT+
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPV----IELSVSENNRRGLYLTTI 491
Query: 866 FAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGV 925
A D D G NA++ Y + ++ F +D G + + + + + + +V A D G
Sbjct: 492 SATDEDSGKNADIVYQLG--PNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGT 549
Query: 926 PPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLH 985
PPLQ QA V + V+ + + N + ENL + +I +D N +
Sbjct: 550 PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD-ADAGENKAVT 608
Query: 986 FSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDV 1045
SI+ D + +F +D +G + + D E S Y F V TD + SST ++I+V
Sbjct: 609 LSILND--NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-PRSSTAKVTINV 665
Query: 1046 EDQNDHSPSFQDELIVISVEEN----------VPIGTLVYVFNAKDDDGSFLNSRIQYYI 1095
D ND+SP +VIS N +P + VF D G +N+ ++Y I
Sbjct: 666 MDVNDNSP------VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG--MNAELKYTI 717
Query: 1096 ESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL-RSL-TAQI 1153
S N F I P G + L+ + PT V VN++D +SL T +
Sbjct: 718 VSGN-NKGLFRIDPVTGNIT----LEEKPAPT---DVGLHRLVVNISDLGYPKSLHTLVL 769
Query: 1154 VILDVND 1160
V L VND
Sbjct: 770 VFLYVND 776
Score = 153 bits (386), Expect = 3e-36
Identities = 130/504 (25%), Positives = 227/504 (45%), Gaps = 41/504 (8%)
Query: 2001 VPESIPVGYSVLTLSATDLES----NENISYRILSSSKE---FSIDPKNGTIFTISPVLL 2053
+PE++P+G L+ + + + + ++ YR++S + + + G IFT S +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRID 93
Query: 2054 LDTISTTQFLVEASDGGNP--------DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
+ + E ++ D L ++I ++D N+ AP F N+S+ E
Sbjct: 94 REKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPE 153
Query: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
+ L+ S S D D T N Y +++G S + ++P L++
Sbjct: 154 NTLINSRFPIPSATDPD-TGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQ-----LIVQ 207
Query: 2166 HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
+LDRE ++ + I D G P SSTA++ + V DVNDN P F H+ E+ P+
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV 267
Query: 2226 GSHITVVSANDRDTGSHAEIIYNI---ISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282
G+ + + A D D GS+AEI Y ++ K F L TG++ + + LD E+
Sbjct: 268 GTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHK 327
Query: 2283 LTVQASDAEKKHFSFAVVFVSVLDDNDHAP----QFMFSSFSCIV--PENLPISSTICSI 2336
+TV ASD + A V ++V D ND+ P +++ S + V E P+++ I I
Sbjct: 328 VTVLASDGSSTP-ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALI 386
Query: 2337 NALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLT 2396
D D G++ I YD+ L +LDYE ++
Sbjct: 387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL--------ETSSLLDYEGTKEFSFK 438
Query: 2397 VQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADA 2454
+ A D G + +V V +E ++ PIF Q ++ E N+ + + A+D D+
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 2455 GIDGVILYSLGTSSPFFSVNKTNG 2478
G + I+Y LG ++ FF +++ G
Sbjct: 499 GKNADIVYQLGPNASFFDLDRKTG 522
Score = 133 bits (334), Expect = 3e-30
Identities = 171/643 (26%), Positives = 268/643 (41%), Gaps = 97/643 (15%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NV 221
+++ ++D NDN P+F SI + T + ATD D+G G YEL+ G +V
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 222 SSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFE 281
L +++ G P++ V + D+E ++ M + KVE D +K
Sbjct: 188 FGLDIVETPEGEKWPQL----IVQQNLDREQKDTYVMKI-------KVE-DGGTPQKSST 235
Query: 282 A-----------SRGWFMRFKGRRHLHYLK--------VQDEAASAD--GEAAARY---- 316
A +R F +G+ +H + +Q A AD A RY
Sbjct: 236 AILQVTVSDVNDNRPVFK--EGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293
Query: 317 -VANLAKIL-----GEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 370
VA K L G+I + L E+ + V A DG A A VTI++
Sbjct: 294 QVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDV 351
Query: 371 TLAPAEFERPKYTFLVYEDVPEDSPI-GTV--KAREPLNSSEPIF-YRISSGDLGGKF-- 424
P + +Y SPI GTV ++P+N+ + D+ GK
Sbjct: 352 NDNPPNIDL-RYII---------SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVIC 401
Query: 425 -----------SIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMD 472
+++ + T LD+E + A P+ + T V + + D
Sbjct: 402 FIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLED 461
Query: 473 VNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRA 532
NDN P F + E+ +S+ G L A D DSG+N I Y + P F +DR
Sbjct: 462 ENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLG-PNASFFDLDRK 520
Query: 533 LGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQ 591
GVL + EQ T+ A D G P Q+ V+ V+++ ++SP +T H +Q
Sbjct: 521 TGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH--FQ 578
Query: 592 VEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQF 649
VSE+L + + + G +A + L D+ F + PY+G I F
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVT-----LSILNDNDNFVLDPYSGVIKSNVSF 633
Query: 650 DYESTQTYNFRVFAWIPEDGFLQNVSTT--VIVRVWDENDNSPTFLH---DVLFLKVEES 704
D E +Y F V A DG S+T V + V D NDNSP + + F V S
Sbjct: 634 DREQQSSYTFDVKA---TDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS 690
Query: 705 PVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTG 745
+P V+ ++ A+D+D+G N +L Y ++S F+++P TG
Sbjct: 691 AIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTG 733
Score = 98.2 bits (243), Expect = 1e-19
Identities = 175/789 (22%), Positives = 309/789 (39%), Gaps = 160/789 (20%)
Query: 7 TKSENEDGEKKMFTQQFESTDACVYEVYV-----------KINSIVKSQSQCGLKRGSPE 55
T S D EK + + C +E+ V KI IVK + SP
Sbjct: 87 TTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPV 146
Query: 56 TELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSY-----EAPQAFR 110
+ +I + + P+ +A+D D+G G Y L +G + E P+ +
Sbjct: 147 INI--SIPENTLINSRFPIP----SATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200
Query: 111 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDV 170
Q+ V Q++DRE+ TY + ++ +DG + S+ A ++V + DV
Sbjct: 201 WP----QLIVQQNLDREQKD-TYVMKIKVEDGGTPQK----------SSTAILQVTVSDV 245
Query: 171 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY----ELIPGNVSSLFT 226
NDN PVF I + GT +I + ATD D G + Y ++ P LF
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA-TKRLFA 304
Query: 227 IDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEK-KFEASRG 285
+++TTGL + + + ++R+E A K AS G
Sbjct: 305 LNNTTGLITVQ-----------------------------RSLDREETAIHKVTVLASDG 335
Query: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSL 345
+ ++ V D + D RY+ + G +YL+ + + +
Sbjct: 336 SSTPARATVTINVTDVNDNPPNID----LRYIISPI----NGTVYLS-EKDPVNTKIALI 386
Query: 346 MVSAQD---GGGLTAVINADVTIHI--------FQTTLAPAEFERPK-YTF-LVYEDVPE 392
VS +D G + I +V H+ T + ++E K ++F +V D +
Sbjct: 387 TVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGK 446
Query: 393 DSPIGTVKAR---EPLNSSEPIFYR---------------------ISSGDLGGKFSIHP 428
S T R E N + PIF + + D G I
Sbjct: 447 PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 429 RLGTIRTRKPLDHET-------------QPVVVLTVQAQ-LGSAPACSSTEVNITVMDVN 474
+LG + LD +T Q + TV A+ G+ P S V +TV+D N
Sbjct: 507 QLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566
Query: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALG 534
DN P F + +S+ P + + + D D+G N + SI + F +D G
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN-FVLDPYSG 625
Query: 535 VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE 593
V+ N S +Q T ++A D G P+++ +T+ V++ ++SP V
Sbjct: 626 VIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSP----------VV 675
Query: 594 VSESLSPMTQMLQTQAHPLGPQRAA-----------SPLRYSLEPSVDSAMFGIRPYTGW 642
+S + +++ A P G A + L+Y++ + +F I P TG
Sbjct: 676 ISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGN 734
Query: 643 IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSPTFLHDVLFLKV 701
I L + T R+ I + G+ +++ T V+V ++ ++ + ++++D L +
Sbjct: 735 ITLEEK--PAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYD-LIRRT 791
Query: 702 EESPVPQGV 710
E+P+ + +
Sbjct: 792 METPLDRNI 800
Score = 72.8 bits (177), Expect = 5e-12
Identities = 81/343 (23%), Positives = 153/343 (44%), Gaps = 54/343 (15%)
Query: 2221 ESTPLGS-----HITVVSANDRDTGSHAEIIYNIIS-GNEKGHFYLEENTGVLYLIKP-L 2273
E+ P+G+ +I+ ++A TG+ A ++Y ++S + + +TG ++ +
Sbjct: 36 ENVPIGNIPKDLNISHINAA---TGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 2274 DYEKMTKFTLTVQASDAEKKHFSFAV--------------VFVSVLDDNDHAPQFMFSSF 2319
D EK L AS AE+ F + + + V D ND+AP F
Sbjct: 93 DREK-----LCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVI 147
Query: 2320 SCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGD- 2378
+ +PEN I+S +A D D G G Y +++ G S L +++ G+
Sbjct: 148 NISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN------GQSV-FGLDIVETPEGEK 200
Query: 2379 ---IHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFT 2433
+ +Q LD E + Y + ++ +D G +++ ++ V + +++ P+F + Q
Sbjct: 201 WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260
Query: 2434 LPEKNKDRQLIGRVEASDADAGIDGVILYSLGT-----SSPFFSVNKTNGNIYLIRALPL 2488
+PE + ++ A+DAD G + I Y G + F++N T G I + R+L
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL-- 318
Query: 2489 IKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTP 2531
++E+T K+ + S A TV +NV+ ++ P
Sbjct: 319 -----DREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPP 356
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 252 bits (643), Expect = 4e-66
Identities = 194/631 (30%), Positives = 294/631 (46%), Gaps = 45/631 (7%)
Query: 999 IDSSTGD----LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
I++ GD L + KELD E Y+ +V D SST L + V D ND+ P
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPV 248
Query: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES--HNPGTNPFLIHPSFG 1112
F++ I +S+ EN P+GT V +A D D N++I + + N F ++ + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGE-NAKIHFSFSNLVSNIARRLFHLNATTG 307
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQA---------VNVTD--RRLRSLTAQIVILDVNDH 1161
+ LDRE P L V ASD VNVTD + S+ + ++ VND
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND- 366
Query: 1162 NPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD---ESS 1218
+ E++ + + + IT D D NG+VT + + F L +
Sbjct: 367 --------TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 1219 GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
LL T LDYE ++ + +LA D G P L+ S L + V D ND APVF Q S+
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 1279 KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQE 1338
EN +PG +T+V A+D DSG N+K+ + + P A E F ++ TG + LDRE ++
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGMLTVVKKLDREKED 534
Query: 1339 VFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLA 1397
+ +L +D G P L+S T+ ++ D+ND++P F + Y+ V EN V +
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1398 SDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+D D G+N AV I+D N D FTI+ +G + + DRE+ ++T + D G
Sbjct: 595 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1458 RSSVIHLQVRVLDANDHSPSF---PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTE 1514
RSS + + V+D ND+ P F P+ V GTVV + AVD D G+N +
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Query: 1515 YFLT-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
Y + F ID +G + D H A D S + VI+ ++V
Sbjct: 713 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ N ++ + V S E+P T I
Sbjct: 773 NESVTNATLINEL---VRKSTEAPVTPNTEI 800
Score = 247 bits (630), Expect = 1e-64
Identities = 191/668 (28%), Positives = 320/668 (47%), Gaps = 52/668 (7%)
Query: 1772 KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ 1831
K+ LI+D NDN+P F ++ S+ E+ N+ A D D G+NG+ Y ++
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 1832 EEAFQI------DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDI 1885
+ D + +I K LD E +Y + V+ D G P+ S+T +++V VTD
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKE-LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 1886 NDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAK-ESNPGTK-FAI 1940
NDN P F +E V I E++ G VT + D D+ N+ FSF+ SN + F +
Sbjct: 243 NDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHL 302
Query: 1941 DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDFY-- 1997
+ TG++ + + LD EE ++LL+ SD A+V V V DVNDN P +
Sbjct: 303 NATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVN 362
Query: 1998 ----QVTVPESIPVGYSVLTLSATDLESNENISYRILSSSK-EFSIDPKNGTIFTISPVL 2052
V + E+IP+ + ++ TD +++ N + + F + P F +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 2053 LLDTISTTQFLVE--ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110
LD ST ++ ++ A+D G P L ++ I ++D N+ AP FT +S+ E+ G
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
L S +D D + N + Y ++ ++ F ++ + G L ++ LDR
Sbjct: 483 IQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR----------TGMLTVVKKLDR 530
Query: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230
E + ILA D+G PPL+S + + ++D NDN P F+ Y+ +V E+ P +
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290
+++ D D G ++ + +I+ N+ F ++ TGV+ D EK +T V+A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648
Query: 2291 EK-KHFSFAVVFVSVLDDNDHAPQFMFSSFSC----IVPENLPISSTICSINALDFDAGP 2345
+ S A V ++V+D ND+ P F+ +C ++P P + + + A+D D G
Sbjct: 649 GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG-- 2403
E+ YSIV DLF ID TG+I + D + + + V+A D G
Sbjct: 708 NAEVRYSIVG--------GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Query: 2404 DATASLVV 2411
D+ S+V+
Sbjct: 760 DSLFSVVI 767
Score = 239 bits (610), Expect = 3e-62
Identities = 211/727 (29%), Positives = 340/727 (46%), Gaps = 80/727 (11%)
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPN 743
D NDN+P F V+ + + E+ A+D D G NG Y L+ F ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 744 TGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRG 803
P G D++ +++ LDRE +
Sbjct: 191 ETPEG-----------------------DKMPQLIVQK--------------ELDREEKD 213
Query: 804 HHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT 863
+ M V V D G P R++T + VSVTD NDN P F + E+ V + E PV VT
Sbjct: 214 TYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE----TEIEVSIPENAPVGTSVT 269
Query: 864 TVFAKDPDEGNNAEVTYSVS---SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
+ A D D G NA++ +S S S + F ++A G I L + P++++ V+A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 921 TDQGVPPLQGQAVVNI----QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
+D G+ P + +VN+ +P R I++ +++ EN+ ++LI +D
Sbjct: 330 SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD 389
Query: 977 QQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL---SKELDYETTSHYLFRVITTDHSKNL 1033
H NG++ D + F + + FL + LDYE+T Y +++ D K
Sbjct: 390 ADH-NGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKP- 444
Query: 1034 SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY 1093
L+ + L I V+D+ND++P F + +S+ EN G + +A D D S N++I Y
Sbjct: 445 PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINY 503
Query: 1094 YIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
+ P F + G L V +LDRE + T+ A D V ++T +
Sbjct: 504 LLGPDAP--PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV---PPLTSNVTVFV 558
Query: 1154 VILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
I+D ND++P F + N +V E++ V IT DPD G N VT SIL +EN F
Sbjct: 559 SIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDF 616
Query: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF--- 1269
+D +G++ D E + + V A D G + SSS +T+ V+DVND PVF
Sbjct: 617 TIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP 676
Query: 1270 -KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVT 1328
YE V + NPG V +V A+D D+G+N+++++ I+ G + +LF I+ +TG +
Sbjct: 677 PSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-- 733
Query: 1329 TTILDR-EIQEVFTLRVLVR--DGGFP-SLSSTTTILCTVEDENDHAP---EFIVSSYDI 1381
T++++ ++ ++ RVLV+ D G P SL S + V + +A E + S +
Sbjct: 734 -TLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEA 792
Query: 1382 EVLENQE 1388
V N E
Sbjct: 793 PVTPNTE 799
Score = 238 bits (608), Expect = 5e-62
Identities = 184/650 (28%), Positives = 302/650 (46%), Gaps = 41/650 (6%)
Query: 829 VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS-VSSEDS 887
+ DINDN P FP + +++ + E +N T A DPD G N Y + S++
Sbjct: 129 IEDINDNAPLFPATV----INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 888 SDHFKIDANNGEIRTTTI----LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSK 943
I+ G+ I L + + +Y M V D G P A++ + V +
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 244
Query: 944 GRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFS---IVADDKDGHFEID 1000
+ + + IPEN ++ + ++D N K+HFS +V++ F ++
Sbjct: 245 NHPVFKETEIEVSIPENAPVGTSVTQLHATD-ADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 1001 SSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
++TG + + + LD E T ++ V+ +D + + + ++V D ND+ PS I
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSIDIRYI 360
Query: 1061 V------ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGT- 1113
V + + EN+P+ T + + D D N R+ + + PF + P F
Sbjct: 361 VNPVNDTVVLSENIPLNTKIALITVTDKDADH-NGRVTCFTDHE----IPFRLRPVFSNQ 415
Query: 1114 --LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPN 1170
L T + LD ES + + A+D + +S I + D ND+ P F SF
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLN---QSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
+ E+ + G + ++A D D G N K+ Y +L + F LD +G+LT LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ +++ T+LA D+G P L+S+ T+ V+++D ND +PVF + Y V EN V
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
+ D D G NS + I+ + F I+S TG + DRE QE +T V DGG
Sbjct: 592 ITVTDPDYGDNSAVTLSILD--ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 649
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIV----SSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
S SS+ + V D ND+ P FIV SY++ + VV+ V+A D D G N
Sbjct: 650 RVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNA 709
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP 1456
V Y I+ GNT + F I++ +G ++ D + +++ +DLG P
Sbjct: 710 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 221 bits (563), Expect = 8e-57
Identities = 182/617 (29%), Positives = 283/617 (45%), Gaps = 27/617 (4%)
Query: 1045 VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP 1104
+ED ND++P F +I IS+ EN I + + A D D + I+S N
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1105 FLIHP---SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDH 1161
+ P L+ LDRE T ++ V D +R + Q+ + D ND+
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGF---PQRSSTAILQVSVTDTNDN 245
Query: 1162 NPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYS---ILSGNENMTFMLDES 1217
+P F + E+ VG+ V + A D D G N K+ +S ++S F L+ +
Sbjct: 246 HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 1218 SGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEAS 1277
+GL+T PLD E H L VLA D G + + + V V DVND P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363
Query: 1278 V------KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTI 1331
V EN + + D+D+ N ++ F L + S+ + T
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423
Query: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV 1391
LD E + + +++L D G P L+ + + V+DEND+AP F S + + EN P +
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 1392 VYT-VLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
T V A D D+G N + Y ++ + F+++ +G L+ + LDRE+ + IL
Sbjct: 484 QLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN 1510
D G PP +S + + V ++D ND+SP F Y V E+ V +++ D D G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1511 GQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK 1570
+ DE + FTID +G ++ + + DRE + +TF A D + SRS++ +
Sbjct: 603 SAVTLSILDE-NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVT 660
Query: 1571 VYVTDVNDNDPVLEQNPFDVFLSPESP-TNQTTVI--VRADDLDLGPNGTVVFSF--AET 1625
+ V DVNDN PV P + P TN TV+ V A D D G N V +S T
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 720
Query: 1626 QSMFSIDKYTGEIQFQQ 1642
+ +F+ID+ TG I +
Sbjct: 721 RDLFAIDQETGNITLME 737
Score = 213 bits (542), Expect = 2e-54
Identities = 173/593 (29%), Positives = 286/593 (48%), Gaps = 43/593 (7%)
Query: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIY 1792
K QL V+ K LD E ++ + V E G A+L + D NDN P F+++
Sbjct: 197 KMPQLIVQ--KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI 254
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYS---ILSGNQEEAFQIDALSGVITTKAI 1849
+ S+ E+ V Q+ ATD D G N I +S ++S F ++A +G+IT K
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP 314
Query: 1850 LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-------LPSEAVEITE 1902
LD E T ++ L+V A+D G+ + ++ V VTD+NDN P+ ++ V ++E
Sbjct: 315 LDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 372
Query: 1903 DSLPGVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY 1961
+ + ++V D D + + + F P + N ++ LD+E EY
Sbjct: 373 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEY 432
Query: 1962 ELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATD 2018
+ + +D+ L ++V D NDN PVF+Q F V++PE+ G + +SA D
Sbjct: 433 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMD 492
Query: 2019 LESNENISYRIL---SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
+S N L + EFS+D + G + T+ L + F + A D G P L
Sbjct: 493 ADSGPNAKINYLLGPDAPPEFSLDCRTGML-TVVKKLDREKEDKYLFTILAKDNGVPPLT 551
Query: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
+ V + I D N+ +P FT YN + E+ T+ + D D+ +N+ V SI+
Sbjct: 552 SNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNSAVTLSIL 610
Query: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV 2195
N ++F +++ Q G + S DRE S+ + A D G SS+A
Sbjct: 611 DEN--DDFTIDS----------QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 2196 ISIQVLDVNDNPPNF----SSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
++I V+DVNDN P F S+ SY + + P G+ + V A D DTG +AE+ Y+I+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVG 717
Query: 2252 GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSV 2304
GN + F +++ TG + L++ D + + V+A+D + F+VV V++
Sbjct: 718 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNL 770
Score = 211 bits (536), Expect = 1e-53
Identities = 191/711 (26%), Positives = 323/711 (45%), Gaps = 60/711 (8%)
Query: 1423 INEMSGELSTTRA-LDREQIS-----------NFTLVILCSDLGDPPRSSVIHLQVRVLD 1470
I E +GE+ TT A +DRE++ + IL ++ ++ ++ + D
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEI-----FRLVKIRFLIED 131
Query: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS--GAFTID 1528
ND++P FP S+ E++ + + + +AVD D G+NG Y L + G I+
Sbjct: 132 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 191
Query: 1529 PMSGT----LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
G L LDRE + + D RS+T I++V VTD NDN PV +
Sbjct: 192 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFK 250
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQ 1639
+ +V + +P + + A D D+G N + FSF+ S +F ++ TG I
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1640 FQQNPSSEYFPIWLQLKVTDQG--IPARTTTGLLVIHMEGE----DVKISFSHHLYKGLV 1693
++ E P L + G +PAR + V + D++ + ++
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370
Query: 1694 TENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
+EN T I + D+ + + + F+ +E S Q ++ +LD+E
Sbjct: 371 SENIPLNTKIALITVTDKDADHNG-RVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYEST 429
Query: 1754 NEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVF 1810
E + +LA +G + A+L ++DENDN+P F QS S+ E+ + +V
Sbjct: 430 KEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVS 489
Query: 1811 ATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
A D DSG N I Y +L + F +D +G++T LD E Y + A D G+P
Sbjct: 490 AMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVDL--NSAFIFS 1927
L++ + V + D NDN+P F +E ++LP V ++V D D NSA S
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLD 1984
E++ F ID TGV+ + D E+ Y ++ D + + + + V+D
Sbjct: 609 ILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVD 665
Query: 1985 VNDNPPVF----SQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKE--F 2036
VNDN PVF S Y++ +P + P G V + A D ++ N + Y I+ + F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPD-LRALTLVEIGIED 2086
+ID + G I + + D + + LV+A+D G PD L ++ +V + + +
Sbjct: 725 AIDQETGNITLMEKCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 208 bits (530), Expect = 5e-53
Identities = 206/743 (27%), Positives = 325/743 (43%), Gaps = 56/743 (7%)
Query: 1270 KQHLYEASVKENQNPGEFVTRVE-ALDRDSGVNSKLQFEIM-PGASFELFEINSDTGEVV 1327
K + + EN G+ + + +L + + + +QF+++ L I DTGE+
Sbjct: 26 KNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIF 85
Query: 1328 TTTI----------LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVS 1377
TT + R+ + + V + + I +ED ND+AP F +
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILP---DEIFRLVKIRFLIEDINDNAPLFPAT 142
Query: 1378 SYDIEVLENQEPEVVYTVLAS-DMDAGNNRAVEYHIIDG-NTDECFTINEMSG----ELS 1431
+I + EN YT+ A+ D D G N Y +I N I G +L
Sbjct: 143 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLI 202
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDA 1491
+ LDRE+ + + + D G P RSS LQV V D ND+ P F + S+ E+A
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 1492 EVGTVVLVLSAVDKDEGLNGQTEY----FLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
VGT V L A D D G N + + +++ A F ++ +G + LDRE
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE----QNPFD--VFLSPESPTNQT 1601
H +A D + +R+ ++ V VTDVNDN P ++ NP + V LS P N
Sbjct: 323 HKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 1602 TVIVRADDLDLGPNGTVV-FSFAE----TQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLK 1656
++ D D NG V F+ E + +FS + S++ + I +L
Sbjct: 380 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI--KLL 437
Query: 1657 VTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQ 1715
D G P + +L I ++ E D F+ + EN G + V A DS
Sbjct: 438 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCK 1772
++ + + SL ++G LTV K LD E ++ +LA+ +G +
Sbjct: 498 NAKINYLLGPDAPPEFSLDCRTGMLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVT 555
Query: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
V V I D+NDNSP F + Y V E+ + V + TD D G N + SIL N +
Sbjct: 556 VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD 615
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF 1892
F ID+ +GVI D E SY+ V+A D G S++ + + V D+NDN P F
Sbjct: 616 --FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 1893 L--PSEAVE--ITEDSLPGVIVTHVSV--HDVDLNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ PS + + PG +V V +D +N+ +S N FAIDQ TG
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-GGNTRDLFAIDQETGN 732
Query: 1947 VVLVKTLDFEEMTEYELLIQISD 1969
+ L++ D ++ + +L++ +D
Sbjct: 733 ITLMEKCDVTDLGLHRVLVKAND 755
Score = 205 bits (521), Expect = 6e-52
Identities = 180/658 (27%), Positives = 294/658 (44%), Gaps = 38/658 (5%)
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS-FELFEI 1319
D+ND AP+F + S+ EN T A+D D G+N +E++ + F L I
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1320 NSDTGEVVTTTI----LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
+ G+ + I LDRE ++ + ++V V DGGFP SST + +V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1376 VSSYDIEVLENQEPEVVYTVL-ASDMDAGNNRAVEY---HIIDGNTDECFTINEMSGELS 1431
+ ++ + EN T L A+D D G N + + +++ F +N +G ++
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR--- 1488
LDRE+ N L++L SD G P +++ V V D ND+ PS Y + V
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTV 368
Query: 1489 ---EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT---LKTSNTLDR 1542
E+ + T + +++ DKD NG+ F E F + P+ L+T+ LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSNQFLLETAAYLDY 426
Query: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
E+ ++ +A D + + + ++ + V D NDN PV Q+ V + +
Sbjct: 427 ESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 1603 VIVRADDLDLGPNGTVVFSFA-ETQSMFSIDKYTGEIQFQQNPSSEYFPIWL-QLKVTDQ 1660
V A D D GPN + + + FS+D TG + + E +L + D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 1661 GIPARTT-TGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-M 1718
G+P T+ + V ++ D F+H+ Y V EN ++ + PD +S +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 1719 KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAV 1775
SI N+D ++ S++G ++ D E + V AE G + KV +
Sbjct: 606 TLSILDENDD--FTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1776 LIQDENDNSPCF---EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
+ D NDN P F + V S V QV A D D+G+N + YSI+ GN
Sbjct: 662 NVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQVTDINDNA 1889
+ F ID +G IT D + ++V+A D G P L + ++ + V + NA
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 179 bits (454), Expect = 4e-44
Identities = 161/677 (23%), Positives = 304/677 (44%), Gaps = 68/677 (10%)
Query: 1899 EITEDSLPGVIVTHVS---VHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVV------- 1948
E+ E+ L G ++ ++ + + L +A F ++ I+++TG +
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 1949 ---LVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESI 2005
L + +E YE+ + I + + + D+NDN P+F +++PE+
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 2006 PVGYSVLTLSAT---DLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLL------DT 2056
+ S TL A D+ N +Y ++ S F +D P L++ +
Sbjct: 153 AIN-SKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116
T V+ DGG P + ++++ + D N+ P F +S+ E+A VG+++
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 2117 SNIDHDWTRENTYVEYS---IISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
D D EN + +S ++S ++ FH+ G + + LDRE +
Sbjct: 272 HATDAD-IGENAKIHFSFSNLVSNIARRLFHLNAT----------TGLITIKEPLDREET 320
Query: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNF------SSLSYHTHVKESTPLGS 2227
+H+L++LASD G P + A++ + V DVNDN P+ + ++ + E+ PL +
Sbjct: 321 PNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 378
Query: 2228 HITVVSANDRDTGSHAEIIYNIISGNEKGHFYLE---ENTGVLYLIKPLDYEKMTKFTLT 2284
I +++ D+D + + + + F L N +L LDYE ++ +
Sbjct: 379 KIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 2285 VQASDAEKKHFS-FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA 2343
+ A+DA K + A++F+ V D+ND+AP F S + +PEN + ++A+D D+
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADS 495
Query: 2344 GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
GP ++ Y + G + F +D TG + + LD E +KY T+ AKD G
Sbjct: 496 GPNAKINYLL--------GPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNG 546
Query: 2404 --DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVIL 2461
T+++ V+V I ++ P+FT ++Y F +PE +G + +D D G + +
Sbjct: 547 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVT 606
Query: 2462 YSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFV 2521
S+ + F+++ G I P I K+++ + A S+ +S V +
Sbjct: 607 LSILDENDDFTIDSQTGVI-----RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 2522 NVSFSSEGTPLAVFASS 2538
NV ++ P+ + S
Sbjct: 662 NVVDVNDNKPVFIVPPS 678
Score = 166 bits (419), Expect = 4e-40
Identities = 170/685 (24%), Positives = 283/685 (41%), Gaps = 66/685 (9%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
++ + D+NDN P F T I I + + + L A D D G NG+ Y + Q
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ- 182
Query: 525 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEK 576
+F +D + L + L E+ + ++ ED G +++ +L V V +
Sbjct: 183 NIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMF 634
++ P F+ +V + E+ T + Q A +G +L ++ +F
Sbjct: 243 NDNHP--VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLF 300
Query: 635 GIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH 694
+ TG I ++ D E T + V A DG L V+V V D NDN P+
Sbjct: 301 HLNATTGLITIKEPLDREETPNHKLLVLA---SDGGLMPARAMVLVNVTDVNDNVPSI-- 355
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
D+ ++ +PV V+ ++ N I +IT
Sbjct: 356 DIRYI---VNPVNDTVV----------------------------LSENIPLNTKIALIT 384
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
D A +G F+ E+ F L+ +F + L LD E + + +L D
Sbjct: 385 VTDKDADHNGRVTCFTDHEI-PFRLRPVFS--NQFLLETAAYLDYESTKEYAIKLLAADA 441
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
G PP N + +++ V D NDN P F Q + V + E + +T V A D D G
Sbjct: 442 GKPPLNQSAMLFIKVKDENDNAPVFTQSF----VTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
NA++ Y + D+ F +D G + L + Y +++A D GVPPL V
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 556
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD 994
+ +I + + + N + +PENL + LI +D Y ++ D++
Sbjct: 557 FVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD---PDYGDNSAVTLSILDEN 613
Query: 995 GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
F IDS TG + + D E Y F V D + +S SS+ ++I+V D ND+ P
Sbjct: 614 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR-VSRSSSAKVTINVVDVNDNKPV 672
Query: 1055 FQDELIVISVEENVPI---GTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
F S E +P GT+V+ A D+D + +N+ ++Y I N + F I
Sbjct: 673 FIVPPSNCSYELVLPSTNPGTVVFQVIAVDND-TGMNAEVRYSIVGGNT-RDLFAIDQET 730
Query: 1112 GTLVTVSRLDRESIPTVILTVTASD 1136
G + + + D + + V A+D
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKAND 755
Score = 122 bits (306), Expect = 5e-27
Identities = 159/626 (25%), Positives = 256/626 (40%), Gaps = 62/626 (9%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NV 221
+R +ED+NDN P+F + SI + + ++ A D D GI G YELI N+
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 222 SSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLP-------------LLRHFKK 268
L I++ G P++ V D+E ++ M + +L+
Sbjct: 185 FGLDVIETPEGDKMPQL----IVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT 240
Query: 269 VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD-GEAA------ARYVANLA 321
D K+ E + + Q A AD GE A + V+N+A
Sbjct: 241 DTNDNHPVFKETEIE----VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 322 KILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 376
+ L G+I + PL E+ L+V A DGG + A V + + +
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356
Query: 377 FER----PKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT 432
T ++ E++P ++ I + + + ++ F + P
Sbjct: 357 IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSN 414
Query: 433 ---IRTRKPLDHE-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
+ T LD+E T+ + + A G P S + I V D NDN P F ++ +
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQR 548
I + PG L A D DSG N I Y + P F++D G+L + L ++
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 549 ELTLTLRAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM-TQMLQ 606
+ T+ A+D GV P + + V +I++ ++SP F H Y V E+L T L
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP--VFTHNEYNFYVPENLPRHGTVGLI 592
Query: 607 TQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 666
T P +A L L+ + D F I TG I FD E ++Y F V A
Sbjct: 593 TVTDPDYGDNSAVTLSI-LDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKA--- 645
Query: 667 EDG--FLQNVSTTVIVRVWDENDNSPTFL---HDVLFLKVEESPVPQGVIGKITAIDMDS 721
EDG ++ S V + V D NDN P F+ + + V S P V+ ++ A+D D+
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDT 705
Query: 722 GKNGQLLYFLLSDG--KFFKMNPNTG 745
G N ++ Y ++ F ++ TG
Sbjct: 706 GMNAEVRYSIVGGNTRDLFAIDQETG 731
Score = 111 bits (277), Expect = 1e-23
Identities = 135/556 (24%), Positives = 226/556 (40%), Gaps = 52/556 (9%)
Query: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
T++ A+DAD G I +S + +S A + F ++ G I + + +DRE P + LL
Sbjct: 269 TQLHATDADIGENAKIHFS-FSNLVSNIARRLFHLNATTGLITIKEPLDREETP-NHKLL 326
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP------VFNPSTYVTSISDET 190
V A DG G + A+A V V++ DVNDN P + NP +S+
Sbjct: 327 VLASDG------------GLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENI 374
Query: 191 QPGTEIINVLATDQDSGIYGTVA--------YELIPGNVSSLFTIDSTTGL--YSPEVEI 240
T+I + TD+D+ G V + L P S+ F +++ L S +
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV-FSNQFLLETAAYLDYESTKEYA 433
Query: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
+ + A K +N M F KV+ + + A ++ + + K
Sbjct: 434 IKLLAADAGKPPLNQSAML------FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 301 VQDEAASADGEAAARYVAN------LAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGG 354
V A + A Y+ + G++ + L + + A+D G
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV 547
Query: 355 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYR 414
N V + I F +Y F V E++P +G + +P + +
Sbjct: 548 PPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP-DYGDNSAVT 606
Query: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS-APACSSTEVNITVMDV 473
+S D F+I + G IR D E Q V+A+ G SS +V I V+DV
Sbjct: 607 LSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 666
Query: 474 NDNHPAFL----RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFA 528
NDN P F+ S E+ + +T PGT ++ A D D+G N +RYSI +FA
Sbjct: 667 NDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 529 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHL 588
ID+ G + L + + ++A D G P + V+ V + E + T +
Sbjct: 726 IDQETGNITLMEKCDVTDLGLHRVLVKANDLG-QPDSLFSVVIVNLFVNESVTNATLINE 784
Query: 589 VYQVEVSESLSPMTQM 604
+ + ++P T++
Sbjct: 785 LVRKSTEAPVTPNTEI 800
Score = 102 bits (255), Expect = 4e-21
Identities = 163/718 (22%), Positives = 277/718 (38%), Gaps = 123/718 (17%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYD-----GFLSYEAPQAFRIDPHDGQICVSQ 122
E +A K T A D D G+ G Y L G E P+ ++ Q+ V +
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP----QLIVQK 205
Query: 123 DIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182
++DRE + TY + V+ +DG + S+ A ++V + D NDNHPVF +
Sbjct: 206 ELDRE-EKDTYVMKVKVEDGGFPQR----------SSTAILQVSVTDTNDNHPVFKETEI 254
Query: 183 VTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTTGLYSPEVE 239
SI + GT + + ATD D G + + L+ LF +++TTGL + +
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK-- 312
Query: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFE-ASRGWFMRFKGRRHLHY 298
+ ++R+E K AS G M + ++
Sbjct: 313 ---------------------------EPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 299 LKVQDEAASADGEAAARYVANLAK---ILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGL 355
V D S D RY+ N +L E I PL+ + A G +
Sbjct: 346 TDVNDNVPSID----IRYIVNPVNDTVVLSENI-----PLNTKIALITVTDKDADHNGRV 396
Query: 356 TAVINADVTIHI--------FQTTLAPAEFERPK--------------------YTFLVY 387
T + ++ + T A ++E K F+
Sbjct: 397 TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 456
Query: 388 EDVPEDSPIGT---VKAREPLNSSEPI-FYRISSGDLGG----------------KFSIH 427
+D +++P+ T V P N+S I ++S+ D +FS+
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD 516
Query: 428 PRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486
R G + K LD E + + T+ A+ G P S+ V ++++D NDN P F
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE 546
+ + P + L D D G N + SI F ID GV+ N S +
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREK 635
Query: 547 QRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTF--EHLVYQVEVSESLSPMTQ 603
Q T ++AED G +++ +T+ V++ ++ P + + Y++ V S +P T
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL-VLPSTNPGTV 694
Query: 604 MLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA 663
+ Q A A +RYS+ +F I TG I L + D T RV
Sbjct: 695 VFQVIAVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETGNITLMEKCDV--TDLGLHRVLV 751
Query: 664 WIPEDGFLQNVSTTVIVRVW-DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
+ G ++ + VIV ++ +E+ + T +++++ E P I +++ D
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 252 bits (643), Expect = 4e-66
Identities = 194/631 (30%), Positives = 294/631 (46%), Gaps = 45/631 (7%)
Query: 999 IDSSTGD----LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
I++ GD L + KELD E Y+ +V D SST L + V D ND+ P
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPV 248
Query: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES--HNPGTNPFLIHPSFG 1112
F++ I +S+ EN P+GT V +A D D N++I + + N F ++ + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGE-NAKIHFSFSNLVSNIARRLFHLNATTG 307
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQA---------VNVTD--RRLRSLTAQIVILDVNDH 1161
+ LDRE P L V ASD VNVTD + S+ + ++ VND
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND- 366
Query: 1162 NPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD---ESS 1218
+ E++ + + + IT D D NG+VT + + F L +
Sbjct: 367 --------TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 1219 GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
LL T LDYE ++ + +LA D G P L+ S L + V D ND APVF Q S+
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 1279 KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQE 1338
EN +PG +T+V A+D DSG N+K+ + + P A E F ++ TG + LDRE ++
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGMLTVVKKLDREKED 534
Query: 1339 VFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLA 1397
+ +L +D G P L+S T+ ++ D+ND++P F + Y+ V EN V +
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1398 SDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+D D G+N AV I+D N D FTI+ +G + + DRE+ ++T + D G
Sbjct: 595 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1458 RSSVIHLQVRVLDANDHSPSF---PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTE 1514
RSS + + V+D ND+ P F P+ V GTVV + AVD D G+N +
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Query: 1515 YFLT-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
Y + F ID +G + D H A D S + VI+ ++V
Sbjct: 713 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ N ++ + V S E+P T I
Sbjct: 773 NESVTNATLINEL---VRKSTEAPVTPNTEI 800
Score = 247 bits (630), Expect = 1e-64
Identities = 191/668 (28%), Positives = 320/668 (47%), Gaps = 52/668 (7%)
Query: 1772 KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ 1831
K+ LI+D NDN+P F ++ S+ E+ N+ A D D G+NG+ Y ++
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 1832 EEAFQI------DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDI 1885
+ D + +I K LD E +Y + V+ D G P+ S+T +++V VTD
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKE-LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 1886 NDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAK-ESNPGTK-FAI 1940
NDN P F +E V I E++ G VT + D D+ N+ FSF+ SN + F +
Sbjct: 243 NDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHL 302
Query: 1941 DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDFY-- 1997
+ TG++ + + LD EE ++LL+ SD A+V V V DVNDN P +
Sbjct: 303 NATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVN 362
Query: 1998 ----QVTVPESIPVGYSVLTLSATDLESNENISYRILSSSK-EFSIDPKNGTIFTISPVL 2052
V + E+IP+ + ++ TD +++ N + + F + P F +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 2053 LLDTISTTQFLVE--ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110
LD ST ++ ++ A+D G P L ++ I ++D N+ AP FT +S+ E+ G
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
L S +D D + N + Y ++ ++ F ++ + G L ++ LDR
Sbjct: 483 IQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR----------TGMLTVVKKLDR 530
Query: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230
E + ILA D+G PPL+S + + ++D NDN P F+ Y+ +V E+ P +
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290
+++ D D G ++ + +I+ N+ F ++ TGV+ D EK +T V+A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648
Query: 2291 EK-KHFSFAVVFVSVLDDNDHAPQFMFSSFSC----IVPENLPISSTICSINALDFDAGP 2345
+ S A V ++V+D ND+ P F+ +C ++P P + + + A+D D G
Sbjct: 649 GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG-- 2403
E+ YSIV DLF ID TG+I + D + + + V+A D G
Sbjct: 708 NAEVRYSIVG--------GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Query: 2404 DATASLVV 2411
D+ S+V+
Sbjct: 760 DSLFSVVI 767
Score = 239 bits (610), Expect = 3e-62
Identities = 211/727 (29%), Positives = 340/727 (46%), Gaps = 80/727 (11%)
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPN 743
D NDN+P F V+ + + E+ A+D D G NG Y L+ F ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 744 TGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRG 803
P G D++ +++ LDRE +
Sbjct: 191 ETPEG-----------------------DKMPQLIVQK--------------ELDREEKD 213
Query: 804 HHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT 863
+ M V V D G P R++T + VSVTD NDN P F + E+ V + E PV VT
Sbjct: 214 TYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE----TEIEVSIPENAPVGTSVT 269
Query: 864 TVFAKDPDEGNNAEVTYSVS---SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
+ A D D G NA++ +S S S + F ++A G I L + P++++ V+A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 921 TDQGVPPLQGQAVVNI----QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
+D G+ P + +VN+ +P R I++ +++ EN+ ++LI +D
Sbjct: 330 SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD 389
Query: 977 QQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL---SKELDYETTSHYLFRVITTDHSKNL 1033
H NG++ D + F + + FL + LDYE+T Y +++ D K
Sbjct: 390 ADH-NGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKP- 444
Query: 1034 SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY 1093
L+ + L I V+D+ND++P F + +S+ EN G + +A D D S N++I Y
Sbjct: 445 PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINY 503
Query: 1094 YIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
+ P F + G L V +LDRE + T+ A D V ++T +
Sbjct: 504 LLGPDAP--PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV---PPLTSNVTVFV 558
Query: 1154 VILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
I+D ND++P F + N +V E++ V IT DPD G N VT SIL +EN F
Sbjct: 559 SIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDF 616
Query: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF--- 1269
+D +G++ D E + + V A D G + SSS +T+ V+DVND PVF
Sbjct: 617 TIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP 676
Query: 1270 -KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVT 1328
YE V + NPG V +V A+D D+G+N+++++ I+ G + +LF I+ +TG +
Sbjct: 677 PSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-- 733
Query: 1329 TTILDR-EIQEVFTLRVLVR--DGGFP-SLSSTTTILCTVEDENDHAP---EFIVSSYDI 1381
T++++ ++ ++ RVLV+ D G P SL S + V + +A E + S +
Sbjct: 734 -TLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEA 792
Query: 1382 EVLENQE 1388
V N E
Sbjct: 793 PVTPNTE 799
Score = 238 bits (608), Expect = 5e-62
Identities = 184/650 (28%), Positives = 302/650 (46%), Gaps = 41/650 (6%)
Query: 829 VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS-VSSEDS 887
+ DINDN P FP + +++ + E +N T A DPD G N Y + S++
Sbjct: 129 IEDINDNAPLFPATV----INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 888 SDHFKIDANNGEIRTTTI----LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSK 943
I+ G+ I L + + +Y M V D G P A++ + V +
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 244
Query: 944 GRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFS---IVADDKDGHFEID 1000
+ + + IPEN ++ + ++D N K+HFS +V++ F ++
Sbjct: 245 NHPVFKETEIEVSIPENAPVGTSVTQLHATD-ADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 1001 SSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
++TG + + + LD E T ++ V+ +D + + + ++V D ND+ PS I
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSIDIRYI 360
Query: 1061 V------ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGT- 1113
V + + EN+P+ T + + D D N R+ + + PF + P F
Sbjct: 361 VNPVNDTVVLSENIPLNTKIALITVTDKDADH-NGRVTCFTDHE----IPFRLRPVFSNQ 415
Query: 1114 --LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPN 1170
L T + LD ES + + A+D + +S I + D ND+ P F SF
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLN---QSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
+ E+ + G + ++A D D G N K+ Y +L + F LD +G+LT LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ +++ T+LA D+G P L+S+ T+ V+++D ND +PVF + Y V EN V
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
+ D D G NS + I+ + F I+S TG + DRE QE +T V DGG
Sbjct: 592 ITVTDPDYGDNSAVTLSILD--ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 649
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIV----SSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
S SS+ + V D ND+ P FIV SY++ + VV+ V+A D D G N
Sbjct: 650 RVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNA 709
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP 1456
V Y I+ GNT + F I++ +G ++ D + +++ +DLG P
Sbjct: 710 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 221 bits (563), Expect = 8e-57
Identities = 182/617 (29%), Positives = 283/617 (45%), Gaps = 27/617 (4%)
Query: 1045 VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP 1104
+ED ND++P F +I IS+ EN I + + A D D + I+S N
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1105 FLIHP---SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDH 1161
+ P L+ LDRE T ++ V D +R + Q+ + D ND+
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGF---PQRSSTAILQVSVTDTNDN 245
Query: 1162 NPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYS---ILSGNENMTFMLDES 1217
+P F + E+ VG+ V + A D D G N K+ +S ++S F L+ +
Sbjct: 246 HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 1218 SGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEAS 1277
+GL+T PLD E H L VLA D G + + + V V DVND P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363
Query: 1278 V------KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTI 1331
V EN + + D+D+ N ++ F L + S+ + T
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423
Query: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV 1391
LD E + + +++L D G P L+ + + V+DEND+AP F S + + EN P +
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 1392 VYT-VLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
T V A D D+G N + Y ++ + F+++ +G L+ + LDRE+ + IL
Sbjct: 484 QLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN 1510
D G PP +S + + V ++D ND+SP F Y V E+ V +++ D D G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1511 GQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK 1570
+ DE + FTID +G ++ + + DRE + +TF A D + SRS++ +
Sbjct: 603 SAVTLSILDE-NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVT 660
Query: 1571 VYVTDVNDNDPVLEQNPFDVFLSPESP-TNQTTVI--VRADDLDLGPNGTVVFSF--AET 1625
+ V DVNDN PV P + P TN TV+ V A D D G N V +S T
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 720
Query: 1626 QSMFSIDKYTGEIQFQQ 1642
+ +F+ID+ TG I +
Sbjct: 721 RDLFAIDQETGNITLME 737
Score = 213 bits (542), Expect = 2e-54
Identities = 173/593 (29%), Positives = 286/593 (48%), Gaps = 43/593 (7%)
Query: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIY 1792
K QL V+ K LD E ++ + V E G A+L + D NDN P F+++
Sbjct: 197 KMPQLIVQ--KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI 254
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYS---ILSGNQEEAFQIDALSGVITTKAI 1849
+ S+ E+ V Q+ ATD D G N I +S ++S F ++A +G+IT K
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP 314
Query: 1850 LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-------LPSEAVEITE 1902
LD E T ++ L+V A+D G+ + ++ V VTD+NDN P+ ++ V ++E
Sbjct: 315 LDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 372
Query: 1903 DSLPGVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY 1961
+ + ++V D D + + + F P + N ++ LD+E EY
Sbjct: 373 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEY 432
Query: 1962 ELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATD 2018
+ + +D+ L ++V D NDN PVF+Q F V++PE+ G + +SA D
Sbjct: 433 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMD 492
Query: 2019 LESNENISYRIL---SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
+S N L + EFS+D + G + T+ L + F + A D G P L
Sbjct: 493 ADSGPNAKINYLLGPDAPPEFSLDCRTGML-TVVKKLDREKEDKYLFTILAKDNGVPPLT 551
Query: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
+ V + I D N+ +P FT YN + E+ T+ + D D+ +N+ V SI+
Sbjct: 552 SNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNSAVTLSIL 610
Query: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV 2195
N ++F +++ Q G + S DRE S+ + A D G SS+A
Sbjct: 611 DEN--DDFTIDS----------QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 2196 ISIQVLDVNDNPPNF----SSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
++I V+DVNDN P F S+ SY + + P G+ + V A D DTG +AE+ Y+I+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVG 717
Query: 2252 GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSV 2304
GN + F +++ TG + L++ D + + V+A+D + F+VV V++
Sbjct: 718 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNL 770
Score = 211 bits (536), Expect = 1e-53
Identities = 191/711 (26%), Positives = 323/711 (45%), Gaps = 60/711 (8%)
Query: 1423 INEMSGELSTTRA-LDREQIS-----------NFTLVILCSDLGDPPRSSVIHLQVRVLD 1470
I E +GE+ TT A +DRE++ + IL ++ ++ ++ + D
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEI-----FRLVKIRFLIED 131
Query: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS--GAFTID 1528
ND++P FP S+ E++ + + + +AVD D G+NG Y L + G I+
Sbjct: 132 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 191
Query: 1529 PMSGT----LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
G L LDRE + + D RS+T I++V VTD NDN PV +
Sbjct: 192 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFK 250
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQ 1639
+ +V + +P + + A D D+G N + FSF+ S +F ++ TG I
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1640 FQQNPSSEYFPIWLQLKVTDQG--IPARTTTGLLVIHMEGE----DVKISFSHHLYKGLV 1693
++ E P L + G +PAR + V + D++ + ++
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370
Query: 1694 TENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
+EN T I + D+ + + + F+ +E S Q ++ +LD+E
Sbjct: 371 SENIPLNTKIALITVTDKDADHNG-RVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYEST 429
Query: 1754 NEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVF 1810
E + +LA +G + A+L ++DENDN+P F QS S+ E+ + +V
Sbjct: 430 KEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVS 489
Query: 1811 ATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
A D DSG N I Y +L + F +D +G++T LD E Y + A D G+P
Sbjct: 490 AMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVDL--NSAFIFS 1927
L++ + V + D NDN+P F +E ++LP V ++V D D NSA S
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLD 1984
E++ F ID TGV+ + D E+ Y ++ D + + + + V+D
Sbjct: 609 ILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVD 665
Query: 1985 VNDNPPVF----SQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKE--F 2036
VNDN PVF S Y++ +P + P G V + A D ++ N + Y I+ + F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPD-LRALTLVEIGIED 2086
+ID + G I + + D + + LV+A+D G PD L ++ +V + + +
Sbjct: 725 AIDQETGNITLMEKCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 208 bits (530), Expect = 5e-53
Identities = 206/743 (27%), Positives = 325/743 (43%), Gaps = 56/743 (7%)
Query: 1270 KQHLYEASVKENQNPGEFVTRVE-ALDRDSGVNSKLQFEIM-PGASFELFEINSDTGEVV 1327
K + + EN G+ + + +L + + + +QF+++ L I DTGE+
Sbjct: 26 KNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIF 85
Query: 1328 TTTI----------LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVS 1377
TT + R+ + + V + + I +ED ND+AP F +
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILP---DEIFRLVKIRFLIEDINDNAPLFPAT 142
Query: 1378 SYDIEVLENQEPEVVYTVLAS-DMDAGNNRAVEYHIIDG-NTDECFTINEMSG----ELS 1431
+I + EN YT+ A+ D D G N Y +I N I G +L
Sbjct: 143 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLI 202
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDA 1491
+ LDRE+ + + + D G P RSS LQV V D ND+ P F + S+ E+A
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 1492 EVGTVVLVLSAVDKDEGLNGQTEY----FLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
VGT V L A D D G N + + +++ A F ++ +G + LDRE
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE----QNPFD--VFLSPESPTNQT 1601
H +A D + +R+ ++ V VTDVNDN P ++ NP + V LS P N
Sbjct: 323 HKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 1602 TVIVRADDLDLGPNGTVV-FSFAE----TQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLK 1656
++ D D NG V F+ E + +FS + S++ + I +L
Sbjct: 380 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI--KLL 437
Query: 1657 VTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQ 1715
D G P + +L I ++ E D F+ + EN G + V A DS
Sbjct: 438 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCK 1772
++ + + SL ++G LTV K LD E ++ +LA+ +G +
Sbjct: 498 NAKINYLLGPDAPPEFSLDCRTGMLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVT 555
Query: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
V V I D+NDNSP F + Y V E+ + V + TD D G N + SIL N +
Sbjct: 556 VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD 615
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF 1892
F ID+ +GVI D E SY+ V+A D G S++ + + V D+NDN P F
Sbjct: 616 --FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 1893 L--PSEAVE--ITEDSLPGVIVTHVSV--HDVDLNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ PS + + PG +V V +D +N+ +S N FAIDQ TG
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-GGNTRDLFAIDQETGN 732
Query: 1947 VVLVKTLDFEEMTEYELLIQISD 1969
+ L++ D ++ + +L++ +D
Sbjct: 733 ITLMEKCDVTDLGLHRVLVKAND 755
Score = 205 bits (521), Expect = 6e-52
Identities = 180/658 (27%), Positives = 294/658 (44%), Gaps = 38/658 (5%)
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS-FELFEI 1319
D+ND AP+F + S+ EN T A+D D G+N +E++ + F L I
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1320 NSDTGEVVTTTI----LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
+ G+ + I LDRE ++ + ++V V DGGFP SST + +V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1376 VSSYDIEVLENQEPEVVYTVL-ASDMDAGNNRAVEY---HIIDGNTDECFTINEMSGELS 1431
+ ++ + EN T L A+D D G N + + +++ F +N +G ++
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR--- 1488
LDRE+ N L++L SD G P +++ V V D ND+ PS Y + V
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTV 368
Query: 1489 ---EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT---LKTSNTLDR 1542
E+ + T + +++ DKD NG+ F E F + P+ L+T+ LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSNQFLLETAAYLDY 426
Query: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
E+ ++ +A D + + + ++ + V D NDN PV Q+ V + +
Sbjct: 427 ESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 1603 VIVRADDLDLGPNGTVVFSFA-ETQSMFSIDKYTGEIQFQQNPSSEYFPIWL-QLKVTDQ 1660
V A D D GPN + + + FS+D TG + + E +L + D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 1661 GIPARTT-TGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-M 1718
G+P T+ + V ++ D F+H+ Y V EN ++ + PD +S +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 1719 KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAV 1775
SI N+D ++ S++G ++ D E + V AE G + KV +
Sbjct: 606 TLSILDENDD--FTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1776 LIQDENDNSPCF---EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
+ D NDN P F + V S V QV A D D+G+N + YSI+ GN
Sbjct: 662 NVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQVTDINDNA 1889
+ F ID +G IT D + ++V+A D G P L + ++ + V + NA
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 179 bits (454), Expect = 4e-44
Identities = 161/677 (23%), Positives = 304/677 (44%), Gaps = 68/677 (10%)
Query: 1899 EITEDSLPGVIVTHVS---VHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVV------- 1948
E+ E+ L G ++ ++ + + L +A F ++ I+++TG +
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 1949 ---LVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESI 2005
L + +E YE+ + I + + + D+NDN P+F +++PE+
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 2006 PVGYSVLTLSAT---DLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLL------DT 2056
+ S TL A D+ N +Y ++ S F +D P L++ +
Sbjct: 153 AIN-SKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116
T V+ DGG P + ++++ + D N+ P F +S+ E+A VG+++
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 2117 SNIDHDWTRENTYVEYS---IISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
D D EN + +S ++S ++ FH+ G + + LDRE +
Sbjct: 272 HATDAD-IGENAKIHFSFSNLVSNIARRLFHLNAT----------TGLITIKEPLDREET 320
Query: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNF------SSLSYHTHVKESTPLGS 2227
+H+L++LASD G P + A++ + V DVNDN P+ + ++ + E+ PL +
Sbjct: 321 PNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 378
Query: 2228 HITVVSANDRDTGSHAEIIYNIISGNEKGHFYLE---ENTGVLYLIKPLDYEKMTKFTLT 2284
I +++ D+D + + + + F L N +L LDYE ++ +
Sbjct: 379 KIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 2285 VQASDAEKKHFS-FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA 2343
+ A+DA K + A++F+ V D+ND+AP F S + +PEN + ++A+D D+
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADS 495
Query: 2344 GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
GP ++ Y + G + F +D TG + + LD E +KY T+ AKD G
Sbjct: 496 GPNAKINYLL--------GPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNG 546
Query: 2404 --DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVIL 2461
T+++ V+V I ++ P+FT ++Y F +PE +G + +D D G + +
Sbjct: 547 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVT 606
Query: 2462 YSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFV 2521
S+ + F+++ G I P I K+++ + A S+ +S V +
Sbjct: 607 LSILDENDDFTIDSQTGVI-----RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 2522 NVSFSSEGTPLAVFASS 2538
NV ++ P+ + S
Sbjct: 662 NVVDVNDNKPVFIVPPS 678
Score = 166 bits (419), Expect = 4e-40
Identities = 170/685 (24%), Positives = 283/685 (41%), Gaps = 66/685 (9%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
++ + D+NDN P F T I I + + + L A D D G NG+ Y + Q
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ- 182
Query: 525 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEK 576
+F +D + L + L E+ + ++ ED G +++ +L V V +
Sbjct: 183 NIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMF 634
++ P F+ +V + E+ T + Q A +G +L ++ +F
Sbjct: 243 NDNHP--VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLF 300
Query: 635 GIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH 694
+ TG I ++ D E T + V A DG L V+V V D NDN P+
Sbjct: 301 HLNATTGLITIKEPLDREETPNHKLLVLA---SDGGLMPARAMVLVNVTDVNDNVPSI-- 355
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
D+ ++ +PV V+ ++ N I +IT
Sbjct: 356 DIRYI---VNPVNDTVV----------------------------LSENIPLNTKIALIT 384
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
D A +G F+ E+ F L+ +F + L LD E + + +L D
Sbjct: 385 VTDKDADHNGRVTCFTDHEI-PFRLRPVFS--NQFLLETAAYLDYESTKEYAIKLLAADA 441
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
G PP N + +++ V D NDN P F Q + V + E + +T V A D D G
Sbjct: 442 GKPPLNQSAMLFIKVKDENDNAPVFTQSF----VTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
NA++ Y + D+ F +D G + L + Y +++A D GVPPL V
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 556
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD 994
+ +I + + + N + +PENL + LI +D Y ++ D++
Sbjct: 557 FVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD---PDYGDNSAVTLSILDEN 613
Query: 995 GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
F IDS TG + + D E Y F V D + +S SS+ ++I+V D ND+ P
Sbjct: 614 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR-VSRSSSAKVTINVVDVNDNKPV 672
Query: 1055 FQDELIVISVEENVPI---GTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
F S E +P GT+V+ A D+D + +N+ ++Y I N + F I
Sbjct: 673 FIVPPSNCSYELVLPSTNPGTVVFQVIAVDND-TGMNAEVRYSIVGGNT-RDLFAIDQET 730
Query: 1112 GTLVTVSRLDRESIPTVILTVTASD 1136
G + + + D + + V A+D
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKAND 755
Score = 122 bits (306), Expect = 5e-27
Identities = 159/626 (25%), Positives = 256/626 (40%), Gaps = 62/626 (9%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NV 221
+R +ED+NDN P+F + SI + + ++ A D D GI G YELI N+
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 222 SSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLP-------------LLRHFKK 268
L I++ G P++ V D+E ++ M + +L+
Sbjct: 185 FGLDVIETPEGDKMPQL----IVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT 240
Query: 269 VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD-GEAA------ARYVANLA 321
D K+ E + + Q A AD GE A + V+N+A
Sbjct: 241 DTNDNHPVFKETEIE----VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 322 KILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 376
+ L G+I + PL E+ L+V A DGG + A V + + +
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356
Query: 377 FER----PKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT 432
T ++ E++P ++ I + + + ++ F + P
Sbjct: 357 IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSN 414
Query: 433 ---IRTRKPLDHE-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
+ T LD+E T+ + + A G P S + I V D NDN P F ++ +
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQR 548
I + PG L A D DSG N I Y + P F++D G+L + L ++
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 549 ELTLTLRAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM-TQMLQ 606
+ T+ A+D GV P + + V +I++ ++SP F H Y V E+L T L
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP--VFTHNEYNFYVPENLPRHGTVGLI 592
Query: 607 TQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 666
T P +A L L+ + D F I TG I FD E ++Y F V A
Sbjct: 593 TVTDPDYGDNSAVTLSI-LDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKA--- 645
Query: 667 EDG--FLQNVSTTVIVRVWDENDNSPTFL---HDVLFLKVEESPVPQGVIGKITAIDMDS 721
EDG ++ S V + V D NDN P F+ + + V S P V+ ++ A+D D+
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDT 705
Query: 722 GKNGQLLYFLLSDG--KFFKMNPNTG 745
G N ++ Y ++ F ++ TG
Sbjct: 706 GMNAEVRYSIVGGNTRDLFAIDQETG 731
Score = 111 bits (277), Expect = 1e-23
Identities = 135/556 (24%), Positives = 226/556 (40%), Gaps = 52/556 (9%)
Query: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
T++ A+DAD G I +S + +S A + F ++ G I + + +DRE P + LL
Sbjct: 269 TQLHATDADIGENAKIHFS-FSNLVSNIARRLFHLNATTGLITIKEPLDREETP-NHKLL 326
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP------VFNPSTYVTSISDET 190
V A DG G + A+A V V++ DVNDN P + NP +S+
Sbjct: 327 VLASDG------------GLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENI 374
Query: 191 QPGTEIINVLATDQDSGIYGTVA--------YELIPGNVSSLFTIDSTTGL--YSPEVEI 240
T+I + TD+D+ G V + L P S+ F +++ L S +
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV-FSNQFLLETAAYLDYESTKEYA 433
Query: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
+ + A K +N M F KV+ + + A ++ + + K
Sbjct: 434 IKLLAADAGKPPLNQSAML------FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 301 VQDEAASADGEAAARYVAN------LAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGG 354
V A + A Y+ + G++ + L + + A+D G
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV 547
Query: 355 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYR 414
N V + I F +Y F V E++P +G + +P + +
Sbjct: 548 PPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP-DYGDNSAVT 606
Query: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS-APACSSTEVNITVMDV 473
+S D F+I + G IR D E Q V+A+ G SS +V I V+DV
Sbjct: 607 LSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 666
Query: 474 NDNHPAFL----RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFA 528
NDN P F+ S E+ + +T PGT ++ A D D+G N +RYSI +FA
Sbjct: 667 NDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 529 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHL 588
ID+ G + L + + ++A D G P + V+ V + E + T +
Sbjct: 726 IDQETGNITLMEKCDVTDLGLHRVLVKANDLG-QPDSLFSVVIVNLFVNESVTNATLINE 784
Query: 589 VYQVEVSESLSPMTQM 604
+ + ++P T++
Sbjct: 785 LVRKSTEAPVTPNTEI 800
Score = 102 bits (255), Expect = 4e-21
Identities = 163/718 (22%), Positives = 277/718 (38%), Gaps = 123/718 (17%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYD-----GFLSYEAPQAFRIDPHDGQICVSQ 122
E +A K T A D D G+ G Y L G E P+ ++ Q+ V +
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP----QLIVQK 205
Query: 123 DIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182
++DRE + TY + V+ +DG + S+ A ++V + D NDNHPVF +
Sbjct: 206 ELDRE-EKDTYVMKVKVEDGGFPQR----------SSTAILQVSVTDTNDNHPVFKETEI 254
Query: 183 VTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTTGLYSPEVE 239
SI + GT + + ATD D G + + L+ LF +++TTGL + +
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK-- 312
Query: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFE-ASRGWFMRFKGRRHLHY 298
+ ++R+E K AS G M + ++
Sbjct: 313 ---------------------------EPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 299 LKVQDEAASADGEAAARYVANLAK---ILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGL 355
V D S D RY+ N +L E I PL+ + A G +
Sbjct: 346 TDVNDNVPSID----IRYIVNPVNDTVVLSENI-----PLNTKIALITVTDKDADHNGRV 396
Query: 356 TAVINADVTIHI--------FQTTLAPAEFERPK--------------------YTFLVY 387
T + ++ + T A ++E K F+
Sbjct: 397 TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 456
Query: 388 EDVPEDSPIGT---VKAREPLNSSEPI-FYRISSGDLGG----------------KFSIH 427
+D +++P+ T V P N+S I ++S+ D +FS+
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD 516
Query: 428 PRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486
R G + K LD E + + T+ A+ G P S+ V ++++D NDN P F
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE 546
+ + P + L D D G N + SI F ID GV+ N S +
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREK 635
Query: 547 QRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTF--EHLVYQVEVSESLSPMTQ 603
Q T ++AED G +++ +T+ V++ ++ P + + Y++ V S +P T
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL-VLPSTNPGTV 694
Query: 604 MLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA 663
+ Q A A +RYS+ +F I TG I L + D T RV
Sbjct: 695 VFQVIAVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETGNITLMEKCDV--TDLGLHRVLV 751
Query: 664 WIPEDGFLQNVSTTVIVRVW-DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
+ G ++ + VIV ++ +E+ + T +++++ E P I +++ D
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 252 bits (643), Expect = 4e-66
Identities = 194/631 (30%), Positives = 294/631 (46%), Gaps = 45/631 (7%)
Query: 999 IDSSTGD----LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
I++ GD L + KELD E Y+ +V D SST L + V D ND+ P
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPV 248
Query: 1055 FQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIES--HNPGTNPFLIHPSFG 1112
F++ I +S+ EN P+GT V +A D D N++I + + N F ++ + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGE-NAKIHFSFSNLVSNIARRLFHLNATTG 307
Query: 1113 TLVTVSRLDRESIPTVILTVTASDQA---------VNVTD--RRLRSLTAQIVILDVNDH 1161
+ LDRE P L V ASD VNVTD + S+ + ++ VND
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND- 366
Query: 1162 NPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLD---ESS 1218
+ E++ + + + IT D D NG+VT + + F L +
Sbjct: 367 --------TVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQ 415
Query: 1219 GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
LL T LDYE ++ + +LA D G P L+ S L + V D ND APVF Q S+
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475
Query: 1279 KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQE 1338
EN +PG +T+V A+D DSG N+K+ + + P A E F ++ TG + LDRE ++
Sbjct: 476 PENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGMLTVVKKLDREKED 534
Query: 1339 VFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLA 1397
+ +L +D G P L+S T+ ++ D+ND++P F + Y+ V EN V +
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITV 594
Query: 1398 SDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
+D D G+N AV I+D N D FTI+ +G + + DRE+ ++T + D G
Sbjct: 595 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1458 RSSVIHLQVRVLDANDHSPSF---PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTE 1514
RSS + + V+D ND+ P F P+ V GTVV + AVD D G+N +
Sbjct: 653 RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVR 712
Query: 1515 YFLT-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
Y + F ID +G + D H A D S + VI+ ++V
Sbjct: 713 YSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
+ N ++ + V S E+P T I
Sbjct: 773 NESVTNATLINEL---VRKSTEAPVTPNTEI 800
Score = 247 bits (630), Expect = 1e-64
Identities = 191/668 (28%), Positives = 320/668 (47%), Gaps = 52/668 (7%)
Query: 1772 KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ 1831
K+ LI+D NDN+P F ++ S+ E+ N+ A D D G+NG+ Y ++
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQN 183
Query: 1832 EEAFQI------DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDI 1885
+ D + +I K LD E +Y + V+ D G P+ S+T +++V VTD
Sbjct: 184 IFGLDVIETPEGDKMPQLIVQKE-LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 1886 NDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAK-ESNPGTK-FAI 1940
NDN P F +E V I E++ G VT + D D+ N+ FSF+ SN + F +
Sbjct: 243 NDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHL 302
Query: 1941 DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDFY-- 1997
+ TG++ + + LD EE ++LL+ SD A+V V V DVNDN P +
Sbjct: 303 NATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVN 362
Query: 1998 ----QVTVPESIPVGYSVLTLSATDLESNENISYRILSSSK-EFSIDPKNGTIFTISPVL 2052
V + E+IP+ + ++ TD +++ N + + F + P F +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 2053 LLDTISTTQFLVE--ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVG 2110
LD ST ++ ++ A+D G P L ++ I ++D N+ AP FT +S+ E+ G
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 2111 STLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDR 2170
L S +D D + N + Y ++ ++ F ++ + G L ++ LDR
Sbjct: 483 IQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR----------TGMLTVVKKLDR 530
Query: 2171 EASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230
E + ILA D+G PPL+S + + ++D NDN P F+ Y+ +V E+ P +
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVG 590
Query: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290
+++ D D G ++ + +I+ N+ F ++ TGV+ D EK +T V+A D
Sbjct: 591 LITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDG 648
Query: 2291 EK-KHFSFAVVFVSVLDDNDHAPQFMFSSFSC----IVPENLPISSTICSINALDFDAGP 2345
+ S A V ++V+D ND+ P F+ +C ++P P + + + A+D D G
Sbjct: 649 GRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGM 707
Query: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG-- 2403
E+ YSIV DLF ID TG+I + D + + + V+A D G
Sbjct: 708 NAEVRYSIVG--------GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Query: 2404 DATASLVV 2411
D+ S+V+
Sbjct: 760 DSLFSVVI 767
Score = 239 bits (610), Expect = 3e-62
Identities = 211/727 (29%), Positives = 340/727 (46%), Gaps = 80/727 (11%)
Query: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPN 743
D NDN+P F V+ + + E+ A+D D G NG Y L+ F ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 744 TGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRG 803
P G D++ +++ LDRE +
Sbjct: 191 ETPEG-----------------------DKMPQLIVQK--------------ELDREEKD 213
Query: 804 HHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT 863
+ M V V D G P R++T + VSVTD NDN P F + E+ V + E PV VT
Sbjct: 214 TYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE----TEIEVSIPENAPVGTSVT 269
Query: 864 TVFAKDPDEGNNAEVTYSVS---SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
+ A D D G NA++ +S S S + F ++A G I L + P++++ V+A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 921 TDQGVPPLQGQAVVNI----QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
+D G+ P + +VN+ +P R I++ +++ EN+ ++LI +D
Sbjct: 330 SDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKD 389
Query: 977 QQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL---SKELDYETTSHYLFRVITTDHSKNL 1033
H NG++ D + F + + FL + LDYE+T Y +++ D K
Sbjct: 390 ADH-NGRV---TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKP- 444
Query: 1034 SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY 1093
L+ + L I V+D+ND++P F + +S+ EN G + +A D D S N++I Y
Sbjct: 445 PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDAD-SGPNAKINY 503
Query: 1094 YIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
+ P F + G L V +LDRE + T+ A D V ++T +
Sbjct: 504 LLGPDAP--PEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV---PPLTSNVTVFV 558
Query: 1154 VILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
I+D ND++P F + N +V E++ V IT DPD G N VT SIL +EN F
Sbjct: 559 SIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDF 616
Query: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF--- 1269
+D +G++ D E + + V A D G + SSS +T+ V+DVND PVF
Sbjct: 617 TIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP 676
Query: 1270 -KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVT 1328
YE V + NPG V +V A+D D+G+N+++++ I+ G + +LF I+ +TG +
Sbjct: 677 PSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-- 733
Query: 1329 TTILDR-EIQEVFTLRVLVR--DGGFP-SLSSTTTILCTVEDENDHAP---EFIVSSYDI 1381
T++++ ++ ++ RVLV+ D G P SL S + V + +A E + S +
Sbjct: 734 -TLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEA 792
Query: 1382 EVLENQE 1388
V N E
Sbjct: 793 PVTPNTE 799
Score = 238 bits (608), Expect = 5e-62
Identities = 184/650 (28%), Positives = 302/650 (46%), Gaps = 41/650 (6%)
Query: 829 VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS-VSSEDS 887
+ DINDN P FP + +++ + E +N T A DPD G N Y + S++
Sbjct: 129 IEDINDNAPLFPATV----INISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 888 SDHFKIDANNGEIRTTTI----LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSK 943
I+ G+ I L + + +Y M V D G P A++ + V +
Sbjct: 185 FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTND 244
Query: 944 GRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFS---IVADDKDGHFEID 1000
+ + + IPEN ++ + ++D N K+HFS +V++ F ++
Sbjct: 245 NHPVFKETEIEVSIPENAPVGTSVTQLHATD-ADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 1001 SSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
++TG + + + LD E T ++ V+ +D + + + ++V D ND+ PS I
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSIDIRYI 360
Query: 1061 V------ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGT- 1113
V + + EN+P+ T + + D D N R+ + + PF + P F
Sbjct: 361 VNPVNDTVVLSENIPLNTKIALITVTDKDADH-NGRVTCFTDHE----IPFRLRPVFSNQ 415
Query: 1114 --LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPN 1170
L T + LD ES + + A+D + +S I + D ND+ P F SF
Sbjct: 416 FLLETAAYLDYESTKEYAIKLLAADAGKPPLN---QSAMLFIKVKDENDNAPVFTQSFVT 472
Query: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230
+ E+ + G + ++A D D G N K+ Y +L + F LD +G+LT LD E
Sbjct: 473 VSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
+ +++ T+LA D+G P L+S+ T+ V+++D ND +PVF + Y V EN V
Sbjct: 532 KEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGL 591
Query: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
+ D D G NS + I+ + F I+S TG + DRE QE +T V DGG
Sbjct: 592 ITVTDPDYGDNSAVTLSILD--ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG 649
Query: 1351 FPSLSSTTTILCTVEDENDHAPEFIV----SSYDIEVLENQEPEVVYTVLASDMDAGNNR 1406
S SS+ + V D ND+ P FIV SY++ + VV+ V+A D D G N
Sbjct: 650 RVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNA 709
Query: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP 1456
V Y I+ GNT + F I++ +G ++ D + +++ +DLG P
Sbjct: 710 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 221 bits (563), Expect = 8e-57
Identities = 182/617 (29%), Positives = 283/617 (45%), Gaps = 27/617 (4%)
Query: 1045 VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP 1104
+ED ND++P F +I IS+ EN I + + A D D + I+S N
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1105 FLIHP---SFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDH 1161
+ P L+ LDRE T ++ V D +R + Q+ + D ND+
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGF---PQRSSTAILQVSVTDTNDN 245
Query: 1162 NPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYS---ILSGNENMTFMLDES 1217
+P F + E+ VG+ V + A D D G N K+ +S ++S F L+ +
Sbjct: 246 HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 1218 SGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEAS 1277
+GL+T PLD E H L VLA D G + + + V V DVND P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNP 363
Query: 1278 V------KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTI 1331
V EN + + D+D+ N ++ F L + S+ + T
Sbjct: 364 VNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAY 423
Query: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV 1391
LD E + + +++L D G P L+ + + V+DEND+AP F S + + EN P +
Sbjct: 424 LDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 1392 VYT-VLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILC 1450
T V A D D+G N + Y ++ + F+++ +G L+ + LDRE+ + IL
Sbjct: 484 QLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1451 SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLN 1510
D G PP +S + + V ++D ND+SP F Y V E+ V +++ D D G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1511 GQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK 1570
+ DE + FTID +G ++ + + DRE + +TF A D + SRS++ +
Sbjct: 603 SAVTLSILDE-NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVT 660
Query: 1571 VYVTDVNDNDPVLEQNPFDVFLSPESP-TNQTTVI--VRADDLDLGPNGTVVFSF--AET 1625
+ V DVNDN PV P + P TN TV+ V A D D G N V +S T
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT 720
Query: 1626 QSMFSIDKYTGEIQFQQ 1642
+ +F+ID+ TG I +
Sbjct: 721 RDLFAIDQETGNITLME 737
Score = 213 bits (542), Expect = 2e-54
Identities = 173/593 (29%), Positives = 286/593 (48%), Gaps = 43/593 (7%)
Query: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIY 1792
K QL V+ K LD E ++ + V E G A+L + D NDN P F+++
Sbjct: 197 KMPQLIVQ--KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI 254
Query: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYS---ILSGNQEEAFQIDALSGVITTKAI 1849
+ S+ E+ V Q+ ATD D G N I +S ++S F ++A +G+IT K
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP 314
Query: 1850 LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-------LPSEAVEITE 1902
LD E T ++ L+V A+D G+ + ++ V VTD+NDN P+ ++ V ++E
Sbjct: 315 LDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 372
Query: 1903 DSLPGVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY 1961
+ + ++V D D + + + F P + N ++ LD+E EY
Sbjct: 373 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEY 432
Query: 1962 ELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATD 2018
+ + +D+ L ++V D NDN PVF+Q F V++PE+ G + +SA D
Sbjct: 433 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMD 492
Query: 2019 LESNENISYRIL---SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
+S N L + EFS+D + G + T+ L + F + A D G P L
Sbjct: 493 ADSGPNAKINYLLGPDAPPEFSLDCRTGML-TVVKKLDREKEDKYLFTILAKDNGVPPLT 551
Query: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
+ V + I D N+ +P FT YN + E+ T+ + D D+ +N+ V SI+
Sbjct: 552 SNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNSAVTLSIL 610
Query: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV 2195
N ++F +++ Q G + S DRE S+ + A D G SS+A
Sbjct: 611 DEN--DDFTIDS----------QTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAK 658
Query: 2196 ISIQVLDVNDNPPNF----SSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
++I V+DVNDN P F S+ SY + + P G+ + V A D DTG +AE+ Y+I+
Sbjct: 659 VTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVG 717
Query: 2252 GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSV 2304
GN + F +++ TG + L++ D + + V+A+D + F+VV V++
Sbjct: 718 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNL 770
Score = 211 bits (536), Expect = 1e-53
Identities = 191/711 (26%), Positives = 323/711 (45%), Gaps = 60/711 (8%)
Query: 1423 INEMSGELSTTRA-LDREQIS-----------NFTLVILCSDLGDPPRSSVIHLQVRVLD 1470
I E +GE+ TT A +DRE++ + IL ++ ++ ++ + D
Sbjct: 77 IEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEI-----FRLVKIRFLIED 131
Query: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS--GAFTID 1528
ND++P FP S+ E++ + + + +AVD D G+NG Y L + G I+
Sbjct: 132 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 191
Query: 1529 PMSGT----LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
G L LDRE + + D RS+T I++V VTD NDN PV +
Sbjct: 192 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQVSVTDTNDNHPVFK 250
Query: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQ 1639
+ +V + +P + + A D D+G N + FSF+ S +F ++ TG I
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1640 FQQNPSSEYFPIWLQLKVTDQG--IPARTTTGLLVIHMEGE----DVKISFSHHLYKGLV 1693
++ E P L + G +PAR + V + D++ + ++
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370
Query: 1694 TENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753
+EN T I + D+ + + + F+ +E S Q ++ +LD+E
Sbjct: 371 SENIPLNTKIALITVTDKDADHNG-RVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYEST 429
Query: 1754 NEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVF 1810
E + +LA +G + A+L ++DENDN+P F QS S+ E+ + +V
Sbjct: 430 KEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVS 489
Query: 1811 ATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
A D DSG N I Y +L + F +D +G++T LD E Y + A D G+P
Sbjct: 490 AMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1871 RLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVDL--NSAFIFS 1927
L++ + V + D NDN+P F +E ++LP V ++V D D NSA S
Sbjct: 549 PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLD 1984
E++ F ID TGV+ + D E+ Y ++ D + + + + V+D
Sbjct: 609 ILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVD 665
Query: 1985 VNDNPPVF----SQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKE--F 2036
VNDN PVF S Y++ +P + P G V + A D ++ N + Y I+ + F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPD-LRALTLVEIGIED 2086
+ID + G I + + D + + LV+A+D G PD L ++ +V + + +
Sbjct: 725 AIDQETGNITLMEKCDVTD-LGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 208 bits (530), Expect = 5e-53
Identities = 206/743 (27%), Positives = 325/743 (43%), Gaps = 56/743 (7%)
Query: 1270 KQHLYEASVKENQNPGEFVTRVE-ALDRDSGVNSKLQFEIM-PGASFELFEINSDTGEVV 1327
K + + EN G+ + + +L + + + +QF+++ L I DTGE+
Sbjct: 26 KNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIF 85
Query: 1328 TTTI----------LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVS 1377
TT + R+ + + V + + I +ED ND+AP F +
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILP---DEIFRLVKIRFLIEDINDNAPLFPAT 142
Query: 1378 SYDIEVLENQEPEVVYTVLAS-DMDAGNNRAVEYHIIDG-NTDECFTINEMSG----ELS 1431
+I + EN YT+ A+ D D G N Y +I N I G +L
Sbjct: 143 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLI 202
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDA 1491
+ LDRE+ + + + D G P RSS LQV V D ND+ P F + S+ E+A
Sbjct: 203 VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENA 262
Query: 1492 EVGTVVLVLSAVDKDEGLNGQTEY----FLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
VGT V L A D D G N + + +++ A F ++ +G + LDRE
Sbjct: 263 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322
Query: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE----QNPFD--VFLSPESPTNQT 1601
H +A D + +R+ ++ V VTDVNDN P ++ NP + V LS P N
Sbjct: 323 HKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 379
Query: 1602 TVIVRADDLDLGPNGTVV-FSFAE----TQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLK 1656
++ D D NG V F+ E + +FS + S++ + I +L
Sbjct: 380 IALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI--KLL 437
Query: 1657 VTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQ 1715
D G P + +L I ++ E D F+ + EN G + V A DS
Sbjct: 438 AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCK 1772
++ + + SL ++G LTV K LD E ++ +LA+ +G +
Sbjct: 498 NAKINYLLGPDAPPEFSLDCRTGMLTV--VKKLDREKEDKYLFTILAKDNGVPPLTSNVT 555
Query: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
V V I D+NDNSP F + Y V E+ + V + TD D G N + SIL N +
Sbjct: 556 VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD 615
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF 1892
F ID+ +GVI D E SY+ V+A D G S++ + + V D+NDN P F
Sbjct: 616 --FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 673
Query: 1893 L--PSEAVE--ITEDSLPGVIVTHVSV--HDVDLNSAFIFSFAKESNPGTKFAIDQNTGV 1946
+ PS + + PG +V V +D +N+ +S N FAIDQ TG
Sbjct: 674 IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV-GGNTRDLFAIDQETGN 732
Query: 1947 VVLVKTLDFEEMTEYELLIQISD 1969
+ L++ D ++ + +L++ +D
Sbjct: 733 ITLMEKCDVTDLGLHRVLVKAND 755
Score = 205 bits (521), Expect = 6e-52
Identities = 180/658 (27%), Positives = 294/658 (44%), Gaps = 38/658 (5%)
Query: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGAS-FELFEI 1319
D+ND AP+F + S+ EN T A+D D G+N +E++ + F L I
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1320 NSDTGEVVTTTI----LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
+ G+ + I LDRE ++ + ++V V DGGFP SST + +V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1376 VSSYDIEVLENQEPEVVYTVL-ASDMDAGNNRAVEY---HIIDGNTDECFTINEMSGELS 1431
+ ++ + EN T L A+D D G N + + +++ F +N +G ++
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 1432 TTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR--- 1488
LDRE+ N L++L SD G P +++ V V D ND+ PS Y + V
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIVNPVNDTV 368
Query: 1489 ---EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT---LKTSNTLDR 1542
E+ + T + +++ DKD NG+ F E F + P+ L+T+ LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSNQFLLETAAYLDY 426
Query: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
E+ ++ +A D + + + ++ + V D NDN PV Q+ V + +
Sbjct: 427 ESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 1603 VIVRADDLDLGPNGTVVFSFA-ETQSMFSIDKYTGEIQFQQNPSSEYFPIWL-QLKVTDQ 1660
V A D D GPN + + + FS+D TG + + E +L + D
Sbjct: 486 TKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN 545
Query: 1661 GIPARTT-TGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-M 1718
G+P T+ + V ++ D F+H+ Y V EN ++ + PD +S +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 1719 KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAV 1775
SI N+D ++ S++G ++ D E + V AE G + KV +
Sbjct: 606 TLSILDENDD--FTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1776 LIQDENDNSPCF---EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
+ D NDN P F + V S V QV A D D+G+N + YSI+ GN
Sbjct: 662 NVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTR 721
Query: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP-RLSNTTVIKVQVTDINDNA 1889
+ F ID +G IT D + ++V+A D G P L + ++ + V + NA
Sbjct: 722 DLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 179 bits (454), Expect = 4e-44
Identities = 161/677 (23%), Positives = 304/677 (44%), Gaps = 68/677 (10%)
Query: 1899 EITEDSLPGVIVTHVS---VHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVV------- 1948
E+ E+ L G ++ ++ + + L +A F ++ I+++TG +
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 1949 ---LVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESI 2005
L + +E YE+ + I + + + D+NDN P+F +++PE+
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENS 152
Query: 2006 PVGYSVLTLSAT---DLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLL------DT 2056
+ S TL A D+ N +Y ++ S F +D P L++ +
Sbjct: 153 AIN-SKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116
T V+ DGG P + ++++ + D N+ P F +S+ E+A VG+++
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 2117 SNIDHDWTRENTYVEYS---IISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
D D EN + +S ++S ++ FH+ G + + LDRE +
Sbjct: 272 HATDAD-IGENAKIHFSFSNLVSNIARRLFHLNAT----------TGLITIKEPLDREET 320
Query: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNF------SSLSYHTHVKESTPLGS 2227
+H+L++LASD G P + A++ + V DVNDN P+ + ++ + E+ PL +
Sbjct: 321 PNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 378
Query: 2228 HITVVSANDRDTGSHAEIIYNIISGNEKGHFYLE---ENTGVLYLIKPLDYEKMTKFTLT 2284
I +++ D+D + + + + F L N +L LDYE ++ +
Sbjct: 379 KIALITVTDKDADHNGRVT---CFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 2285 VQASDAEKKHFS-FAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA 2343
+ A+DA K + A++F+ V D+ND+AP F S + +PEN + ++A+D D+
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADS 495
Query: 2344 GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
GP ++ Y + G + F +D TG + + LD E +KY T+ AKD G
Sbjct: 496 GPNAKINYLL--------GPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNG 546
Query: 2404 --DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVIL 2461
T+++ V+V I ++ P+FT ++Y F +PE +G + +D D G + +
Sbjct: 547 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVT 606
Query: 2462 YSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFV 2521
S+ + F+++ G I P I K+++ + A S+ +S V +
Sbjct: 607 LSILDENDDFTIDSQTGVI-----RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 2522 NVSFSSEGTPLAVFASS 2538
NV ++ P+ + S
Sbjct: 662 NVVDVNDNKPVFIVPPS 678
Score = 166 bits (419), Expect = 4e-40
Identities = 170/685 (24%), Positives = 283/685 (41%), Gaps = 66/685 (9%)
Query: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 524
++ + D+NDN P F T I I + + + L A D D G NG+ Y + Q
Sbjct: 124 KIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ- 182
Query: 525 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEK 576
+F +D + L + L E+ + ++ ED G +++ +L V V +
Sbjct: 183 NIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Query: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMF 634
++ P F+ +V + E+ T + Q A +G +L ++ +F
Sbjct: 243 NDNHP--VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLF 300
Query: 635 GIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH 694
+ TG I ++ D E T + V A DG L V+V V D NDN P+
Sbjct: 301 HLNATTGLITIKEPLDREETPNHKLLVLA---SDGGLMPARAMVLVNVTDVNDNVPSI-- 355
Query: 695 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
D+ ++ +PV V+ ++ N I +IT
Sbjct: 356 DIRYI---VNPVNDTVV----------------------------LSENIPLNTKIALIT 384
Query: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
D A +G F+ E+ F L+ +F + L LD E + + +L D
Sbjct: 385 VTDKDADHNGRVTCFTDHEI-PFRLRPVFS--NQFLLETAAYLDYESTKEYAIKLLAADA 441
Query: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
G PP N + +++ V D NDN P F Q + V + E + +T V A D D G
Sbjct: 442 GKPPLNQSAMLFIKVKDENDNAPVFTQSF----VTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
NA++ Y + D+ F +D G + L + Y +++A D GVPPL V
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 556
Query: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD 994
+ +I + + + N + +PENL + LI +D Y ++ D++
Sbjct: 557 FVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTD---PDYGDNSAVTLSILDEN 613
Query: 995 GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPS 1054
F IDS TG + + D E Y F V D + +S SS+ ++I+V D ND+ P
Sbjct: 614 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR-VSRSSSAKVTINVVDVNDNKPV 672
Query: 1055 FQDELIVISVEENVPI---GTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSF 1111
F S E +P GT+V+ A D+D + +N+ ++Y I N + F I
Sbjct: 673 FIVPPSNCSYELVLPSTNPGTVVFQVIAVDND-TGMNAEVRYSIVGGNT-RDLFAIDQET 730
Query: 1112 GTLVTVSRLDRESIPTVILTVTASD 1136
G + + + D + + V A+D
Sbjct: 731 GNITLMEKCDVTDLGLHRVLVKAND 755
Score = 122 bits (306), Expect = 5e-27
Identities = 159/626 (25%), Positives = 256/626 (40%), Gaps = 62/626 (9%)
Query: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NV 221
+R +ED+NDN P+F + SI + + ++ A D D GI G YELI N+
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI 184
Query: 222 SSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLP-------------LLRHFKK 268
L I++ G P++ V D+E ++ M + +L+
Sbjct: 185 FGLDVIETPEGDKMPQL----IVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT 240
Query: 269 VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD-GEAA------ARYVANLA 321
D K+ E + + Q A AD GE A + V+N+A
Sbjct: 241 DTNDNHPVFKETEIE----VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 322 KILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 376
+ L G+I + PL E+ L+V A DGG + A V + + +
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356
Query: 377 FER----PKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT 432
T ++ E++P ++ I + + + ++ F + P
Sbjct: 357 IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI--PFRLRPVFSN 414
Query: 433 ---IRTRKPLDHE-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR 488
+ T LD+E T+ + + A G P S + I V D NDN P F ++ +
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQR 548
I + PG L A D DSG N I Y + P F++D G+L + L ++
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKED 534
Query: 549 ELTLTLRAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM-TQMLQ 606
+ T+ A+D GV P + + V +I++ ++SP F H Y V E+L T L
Sbjct: 535 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP--VFTHNEYNFYVPENLPRHGTVGLI 592
Query: 607 TQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 666
T P +A L L+ + D F I TG I FD E ++Y F V A
Sbjct: 593 TVTDPDYGDNSAVTLSI-LDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKA--- 645
Query: 667 EDG--FLQNVSTTVIVRVWDENDNSPTFL---HDVLFLKVEESPVPQGVIGKITAIDMDS 721
EDG ++ S V + V D NDN P F+ + + V S P V+ ++ A+D D+
Sbjct: 646 EDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDT 705
Query: 722 GKNGQLLYFLLSDG--KFFKMNPNTG 745
G N ++ Y ++ F ++ TG
Sbjct: 706 GMNAEVRYSIVGGNTRDLFAIDQETG 731
Score = 111 bits (277), Expect = 1e-23
Identities = 135/556 (24%), Positives = 226/556 (40%), Gaps = 52/556 (9%)
Query: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
T++ A+DAD G I +S + +S A + F ++ G I + + +DRE P + LL
Sbjct: 269 TQLHATDADIGENAKIHFS-FSNLVSNIARRLFHLNATTGLITIKEPLDREETP-NHKLL 326
Query: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP------VFNPSTYVTSISDET 190
V A DG G + A+A V V++ DVNDN P + NP +S+
Sbjct: 327 VLASDG------------GLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENI 374
Query: 191 QPGTEIINVLATDQDSGIYGTVA--------YELIPGNVSSLFTIDSTTGL--YSPEVEI 240
T+I + TD+D+ G V + L P S+ F +++ L S +
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV-FSNQFLLETAAYLDYESTKEYA 433
Query: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
+ + A K +N M F KV+ + + A ++ + + K
Sbjct: 434 IKLLAADAGKPPLNQSAML------FIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 301 VQDEAASADGEAAARYVAN------LAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGG 354
V A + A Y+ + G++ + L + + A+D G
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGV 547
Query: 355 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYR 414
N V + I F +Y F V E++P +G + +P + +
Sbjct: 548 PPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP-DYGDNSAVT 606
Query: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS-APACSSTEVNITVMDV 473
+S D F+I + G IR D E Q V+A+ G SS +V I V+DV
Sbjct: 607 LSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDV 666
Query: 474 NDNHPAFL----RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFA 528
NDN P F+ S E+ + +T PGT ++ A D D+G N +RYSI +FA
Sbjct: 667 NDNKPVFIVPPSNCSYEL-VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFA 725
Query: 529 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHL 588
ID+ G + L + + ++A D G P + V+ V + E + T +
Sbjct: 726 IDQETGNITLMEKCDVTDLGLHRVLVKANDLG-QPDSLFSVVIVNLFVNESVTNATLINE 784
Query: 589 VYQVEVSESLSPMTQM 604
+ + ++P T++
Sbjct: 785 LVRKSTEAPVTPNTEI 800
Score = 102 bits (255), Expect = 4e-21
Identities = 163/718 (22%), Positives = 277/718 (38%), Gaps = 123/718 (17%)
Query: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYD-----GFLSYEAPQAFRIDPHDGQICVSQ 122
E +A K T A D D G+ G Y L G E P+ ++ Q+ V +
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP----QLIVQK 205
Query: 123 DIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182
++DRE + TY + V+ +DG + S+ A ++V + D NDNHPVF +
Sbjct: 206 ELDRE-EKDTYVMKVKVEDGGFPQR----------SSTAILQVSVTDTNDNHPVFKETEI 254
Query: 183 VTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTTGLYSPEVE 239
SI + GT + + ATD D G + + L+ LF +++TTGL + +
Sbjct: 255 EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK-- 312
Query: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFE-ASRGWFMRFKGRRHLHY 298
+ ++R+E K AS G M + ++
Sbjct: 313 ---------------------------EPLDREETPNHKLLVLASDGGLMPARAMVLVNV 345
Query: 299 LKVQDEAASADGEAAARYVANLAK---ILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGL 355
V D S D RY+ N +L E I PL+ + A G +
Sbjct: 346 TDVNDNVPSID----IRYIVNPVNDTVVLSENI-----PLNTKIALITVTDKDADHNGRV 396
Query: 356 TAVINADVTIHI--------FQTTLAPAEFERPK--------------------YTFLVY 387
T + ++ + T A ++E K F+
Sbjct: 397 TCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 456
Query: 388 EDVPEDSPIGT---VKAREPLNSSEPI-FYRISSGDLGG----------------KFSIH 427
+D +++P+ T V P N+S I ++S+ D +FS+
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD 516
Query: 428 PRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486
R G + K LD E + + T+ A+ G P S+ V ++++D NDN P F
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Query: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE 546
+ + P + L D D G N + SI F ID GV+ N S +
Sbjct: 577 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVIRPNISFDREK 635
Query: 547 QRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTF--EHLVYQVEVSESLSPMTQ 603
Q T ++AED G +++ +T+ V++ ++ P + + Y++ V S +P T
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL-VLPSTNPGTV 694
Query: 604 MLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA 663
+ Q A A +RYS+ +F I TG I L + D T RV
Sbjct: 695 VFQVIAVDNDTGMNAE-VRYSIVGGNTRDLFAIDQETGNITLMEKCDV--TDLGLHRVLV 751
Query: 664 WIPEDGFLQNVSTTVIVRVW-DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720
+ G ++ + VIV ++ +E+ + T +++++ E P I +++ D
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,179,449
Number of Sequences: 37866
Number of extensions: 4969076
Number of successful extensions: 38265
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 11984
Number of HSP's gapped (non-prelim): 4597
length of query: 2916
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2796
effective length of database: 13,703,598
effective search space: 38315260008
effective search space used: 38315260008
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.