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Search of human proteins with 45594240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
(338 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45594240 limbic system-associated membrane protein [Homo sapi... 678 0.0
gi|7705413 neurotrimin isoform 1 [Homo sapiens] 374 e-104
gi|4505505 opioid binding protein/cell adhesion molecule-like is... 368 e-102
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 366 e-101
gi|66346706 neuronal growth regulator 1 [Homo sapiens] 364 e-101
gi|115298665 neurotrimin isoform 2 [Homo sapiens] 361 e-100
gi|221316762 neurotrimin isoform 4 [Homo sapiens] 358 3e-99
gi|59939900 opioid binding protein/cell adhesion molecule-like i... 353 2e-97
gi|157819143 IgLON family member 5 [Homo sapiens] 298 5e-81
gi|118572606 hemicentin 1 [Homo sapiens] 109 3e-24
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 108 7e-24
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 108 7e-24
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 108 7e-24
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 107 2e-23
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 107 2e-23
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 102 5e-22
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 100 2e-21
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 100 2e-21
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 100 3e-21
gi|109150416 peroxidasin [Homo sapiens] 97 2e-20
gi|126517478 peroxidasin homolog-like [Homo sapiens] 94 1e-19
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 93 3e-19
gi|110349719 titin isoform N2-A [Homo sapiens] 89 7e-18
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 87 2e-17
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens] 87 2e-17
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 86 4e-17
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 86 4e-17
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 85 1e-16
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 84 1e-16
gi|7657359 contactin 5 isoform long [Homo sapiens] 84 2e-16
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 678 bits (1749), Expect = 0.0
Identities = 338/338 (100%), Positives = 338/338 (100%)
Query: 1 MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS 60
MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS
Sbjct: 1 MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS 60
Query: 61 KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPK 120
KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPK
Sbjct: 61 KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPK 120
Query: 121 TSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE 180
TSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE
Sbjct: 121 TSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE 180
Query: 181 YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCE 240
YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCE
Sbjct: 181 YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCE 240
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN
Sbjct: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
Query: 301 ASLVLFRPGSVRGINGSISLAVPLWLLAASLLCLLSKC 338
ASLVLFRPGSVRGINGSISLAVPLWLLAASLLCLLSKC
Sbjct: 301 ASLVLFRPGSVRGINGSISLAVPLWLLAASLLCLLSKC 338
>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
Length = 344
Score = 374 bits (959), Expect = e-104
Identities = 186/332 (56%), Positives = 248/332 (74%), Gaps = 4/332 (1%)
Query: 10 KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67
K L +V LRLL L+PTG+PVRS D F + DN+TVRQG++A LRC ++++ ++VAWLNR
Sbjct: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
Query: 68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127
S I++AG+DKW LDPRV L +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 72 STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
Query: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGI 187
VQV PKI ISSD+++NEG+N++L C+A GRPEP +TWRH++P F E+EYLEI GI
Sbjct: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
Query: 188 TREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAP 247
TREQSG YEC A+N+V++ V++VKVTVNYPP I+E+K G++ +L+CEASAVP+
Sbjct: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSA 251
Query: 248 DFEWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+F+WY+DD R I G+++++ S L NV+E YGNYTCVA+NKLG TNAS++LF
Sbjct: 252 EFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
Query: 307 RPGSVRGI-NGSISLAVPLWLLAASLLCLLSK 337
PG+V + NG+ A +WLL +L LL K
Sbjct: 312 GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLK 343
>gi|4505505 opioid binding protein/cell adhesion molecule-like
isoform a preproprotein [Homo sapiens]
Length = 345
Score = 368 bits (944), Expect = e-102
Identities = 181/322 (56%), Positives = 247/322 (76%), Gaps = 5/322 (1%)
Query: 10 KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67
K L +V LRLL L+PTG+PVRS D F + DN+TVRQG++A LRC ++D+ ++VAWLNR
Sbjct: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNR 71
Query: 68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127
S I++AG+DKWS+DPRV + +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 72 STILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
Query: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLT-PTGREFEGEEEYLEILG 186
VQVPP+I NISSD+TVNEGS+VTL+C+A GRPEP +TWRHL+ G+ F E+EYLEI
Sbjct: 132 VQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISD 191
Query: 187 ITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPA 246
I R+QSG+YEC A N+V++ DV++VK+TVNYPP I+++K+ + G++ L CEASAVP
Sbjct: 192 IKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPM 251
Query: 247 PDFEWYRDDTRINSA-NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+F+W++++TR+ + +G+ I++ S+LT NV+E+ YGNYTCVA NKLG TNAS+ L
Sbjct: 252 AEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITL 311
Query: 306 FRPGSV-RGINGSISLAVPLWL 326
+ PG+V G+N + LWL
Sbjct: 312 YGPGAVIDGVNSASRALACLWL 333
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 366 bits (939), Expect = e-101
Identities = 186/343 (54%), Positives = 248/343 (72%), Gaps = 15/343 (4%)
Query: 10 KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67
K L +V LRLL L+PTG+PVRS D F + DN+TVRQG++A LRC ++++ ++VAWLNR
Sbjct: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
Query: 68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127
S I++AG+DKW LDPRV L +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 72 STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
Query: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGI 187
VQV PKI ISSD+++NEG+N++L C+A GRPEP +TWRH++P F E+EYLEI GI
Sbjct: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
Query: 188 TREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAP 247
TREQSG YEC A+N+V++ V++VKVTVNYPP I+E+K G++ +L+CEASAVP+
Sbjct: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSA 251
Query: 248 DFEWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+F+WY+DD R I G+++++ S L NV+E YGNYTCVA+NKLG TNAS++LF
Sbjct: 252 EFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
Query: 307 R-----------PGSVRGI-NGSISLAVPLWLLAASLLCLLSK 337
PG+V + NG+ A +WLL +L LL K
Sbjct: 312 EVKTTALTPWKGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLK 354
>gi|66346706 neuronal growth regulator 1 [Homo sapiens]
Length = 354
Score = 364 bits (935), Expect = e-101
Identities = 185/324 (57%), Positives = 236/324 (72%), Gaps = 5/324 (1%)
Query: 12 LPLVLLRLLCLLPTGLPV-RSVDFN-RGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSG 69
L VLL L CLLP+ LP +SVDF DN+ VR+GDTA+LRC +ED SK AWLNRS
Sbjct: 17 LAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSS 76
Query: 70 IIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ 129
IIFAG DKWS+DPRV + + +YSL+IQ VDV D+G YTCSVQTQH P+T QV+L VQ
Sbjct: 77 IIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQ 136
Query: 130 VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITR 189
VPPKI +IS+D+TVNEG+NVTL C+A G+PEP I+WRH++P+ + FE +YL+I GITR
Sbjct: 137 VPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFE-NGQYLDIYGITR 195
Query: 190 EQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDF 249
+Q+G+YEC A N+VS DV++VKV VN+ PTI E KS T GR ++CE + VP P F
Sbjct: 196 DQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAF 255
Query: 250 EWYRDDTRI-NSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRP 308
EWY+ + ++ N G+ I++ +S LTVTNVT+EH+GNYTCVAANKLG TNASL L P
Sbjct: 256 EWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPP 315
Query: 309 GSVR-GINGSISLAVPLWLLAASL 331
+ + GI GS + W L +L
Sbjct: 316 STAQYGITGSADVLFSCWYLVLTL 339
>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
Length = 344
Score = 361 bits (926), Expect = e-100
Identities = 180/325 (55%), Positives = 240/325 (73%), Gaps = 5/325 (1%)
Query: 17 LRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAG 74
L LCL G+PVRS D F + DN+TVRQG++A LRC ++++ ++VAWLNRS I++AG
Sbjct: 20 LAALCLFQ-GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAG 78
Query: 75 HDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI 134
+DKW LDPRV L +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LIVQV PKI
Sbjct: 79 NDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI 138
Query: 135 SNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGK 194
ISSD+++NEG+N++L C+A GRPEP +TWRH++P F E+EYLEI GITREQSG
Sbjct: 139 VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGD 198
Query: 195 YECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRD 254
YEC A+N+V++ V++VKVTVNYPP I+E+K G++ +L+CEASAVP+ +F+WY+D
Sbjct: 199 YECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKD 258
Query: 255 DTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRG 313
D R I G+++++ S L NV+E YGNYTCVA+NKLG TNAS++LF PG+V
Sbjct: 259 DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSE 318
Query: 314 I-NGSISLAVPLWLLAASLLCLLSK 337
+ NG+ A +WLL +L LL K
Sbjct: 319 VSNGTSRRAGCVWLLPLLVLHLLLK 343
>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
Length = 316
Score = 358 bits (920), Expect = 3e-99
Identities = 173/300 (57%), Positives = 230/300 (76%), Gaps = 3/300 (1%)
Query: 10 KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67
K L +V LRLL L+PTG+PVRS D F + DN+TVRQG++A LRC ++++ ++VAWLNR
Sbjct: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
Query: 68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127
S I++AG+DKW LDPRV L +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 72 STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
Query: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGI 187
VQV PKI ISSD+++NEG+N++L C+A GRPEP +TWRH++P F E+EYLEI GI
Sbjct: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
Query: 188 TREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAP 247
TREQSG YEC A+N+V++ V++VKVTVNYPP I+E+K G++ +L+CEASAVP+
Sbjct: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSA 251
Query: 248 DFEWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+F+WY+DD R I G+++++ S L NV+E YGNYTCVA+NKLG TNAS++LF
Sbjct: 252 EFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
>gi|59939900 opioid binding protein/cell adhesion molecule-like
isoform b preproprotein [Homo sapiens]
Length = 338
Score = 353 bits (905), Expect = 2e-97
Identities = 171/306 (55%), Positives = 235/306 (76%), Gaps = 5/306 (1%)
Query: 26 GLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPR 83
G+PVRS D F + DN+TVRQG++A LRC ++D+ ++VAWLNRS I++AG+DKWS+DPR
Sbjct: 21 GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPR 80
Query: 84 VELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV 143
V + +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LIVQVPP+I NISSD+TV
Sbjct: 81 VIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITV 140
Query: 144 NEGSNVTLVCMANGRPEPVITWRHLT-PTGREFEGEEEYLEILGITREQSGKYECKAANE 202
NEGS+VTL+C+A GRPEP +TWRHL+ G+ F E+EYLEI I R+QSG+YEC A N+
Sbjct: 141 NEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALND 200
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSA- 261
V++ DV++VK+TVNYPP I+++K+ + G++ L CEASAVP +F+W++++TR+ +
Sbjct: 201 VAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGL 260
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSV-RGINGSISL 320
+G+ I++ S+LT NV+E+ YGNYTCVA NKLG TNAS+ L+ PG+V G+N +
Sbjct: 261 DGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRA 320
Query: 321 AVPLWL 326
LWL
Sbjct: 321 LACLWL 326
>gi|157819143 IgLON family member 5 [Homo sapiens]
Length = 336
Score = 298 bits (763), Expect = 5e-81
Identities = 154/295 (52%), Positives = 203/295 (68%), Gaps = 6/295 (2%)
Query: 20 LCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWS 79
L ++ GL +S++FN DN TV +GD A L C +++ ++VAWLNRS I++AG+D+W+
Sbjct: 21 LAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWT 80
Query: 80 LDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISS 139
DPRV L E+S+ I +V + DEG YTCS QT+H+P T+QVYLIV VP +I NISS
Sbjct: 81 SDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISS 140
Query: 140 DVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKA 199
VTVNEG NV L+C+A GRPEP +TWR L F E E LEI I R Q+G+YEC
Sbjct: 141 PVTVNEGGNVNLLCLAVGRPEPTVTWRQLRD---GFTSEGEILEISDIQRGQAGEYECVT 197
Query: 200 ANEVSSA-DVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI 258
N V+SA D ++V VTVNYPPTIT+ S GR A L+CEA AVP DF+WY+DD +
Sbjct: 198 HNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLL 257
Query: 259 NS--ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSV 311
+S A GL++++ +S L NV+ HYGNYTC AAN+LG ++AS+ L RPGS+
Sbjct: 258 SSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSL 312
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 109 bits (273), Expect = 3e-24
Identities = 71/214 (33%), Positives = 105/214 (49%), Gaps = 12/214 (5%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSD----VTVNEGSNVT 150
+L+I + V D G YTC Q + L V VPP I + S+ V V EG++V+
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVS 3078
Query: 151 LVCMANGRPEPVITW----RHLTP-TGREFEGEEEYLEILGITREQSGKYECKAANEVSS 205
L C +N P PVITW R +T T E + + L I +G+Y C+A N V+
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAG 3137
Query: 206 ADVKQVKVTVNYPPTIT--ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
D K + V PP+I E + T +L C+A+ +P P W ++ RI +++
Sbjct: 3138 RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDS 3197
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
LE++ G S L + GNYTC+A+N G
Sbjct: 3198 LEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Score = 106 bits (265), Expect = 3e-23
Identities = 75/233 (32%), Positives = 101/233 (43%), Gaps = 14/233 (6%)
Query: 78 WSLDPRVELE---KRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI 134
W D R +E +R SL+I V D G YTC ++ L V VPP+I
Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171
Query: 135 SNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGE---EEYLEIL--GITR 189
+ TVNE S L C+A+G P P I W+ G+ E Y E++ +
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL 4231
Query: 190 EQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPD 248
E SG Y C AN + D V +TV+ PT TE + G Q L C+A+ +P P
Sbjct: 4232 EDSGFYTC-VANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPK 4290
Query: 249 FEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA 301
W T N+ S G S L + V++E G Y C A N +G A
Sbjct: 4291 LTW----TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Score = 103 bits (258), Expect = 2e-22
Identities = 83/286 (29%), Positives = 130/286 (45%), Gaps = 24/286 (8%)
Query: 31 SVDFNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKR 89
++D + GT+ ITV +G + + C+ + + +AWL R G LD + +
Sbjct: 3435 NMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWL-RDG------QPLGLDAHLTVSTH 3487
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGS 147
+ L++ K + D G YTC + + L V PP I S +++V +
Sbjct: 3488 GMV---LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNN 3544
Query: 148 NVTLVCMANGRPEPVITW----RHLTPTGR-EFEGEEEYLEILGITREQSGKYECKAANE 202
+ L C+A+G P P +TW R L T + + G E L I E +G+Y C A++
Sbjct: 3545 PLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSP 3604
Query: 203 VSSADVKQVKVTVNYPPTIT---ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRIN 259
D K+ V V+ PP I E + RQ +L+C++ AVP P W R+ R+
Sbjct: 3605 AGDDD-KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQ 3663
Query: 260 SANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + I S G L + N NYTCVA+N G T +L
Sbjct: 3664 ATPRVRILS--GGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Score = 99.8 bits (247), Expect = 3e-21
Identities = 78/271 (28%), Positives = 113/271 (41%), Gaps = 22/271 (8%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGH-DKWSLDPRVELEKRHSLEYSLRIQK 100
TV + AIL CV + + + ++ A K++ +P EL ++
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELI----------LEN 4228
Query: 101 VDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPE 160
V + D G YTC T V L V V P + + DV++N+G + L C A G P
Sbjct: 4229 VVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPL 4288
Query: 161 PVITW---RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK-VTVN 216
P +TW ++ P + L I +++E SG Y C A N V VK + V V
Sbjct: 4289 PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGF--VKAIGFVYVK 4346
Query: 217 YPPTITESKSNE--ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSS 274
PP + G A L CE P P +W R I ++ + G S
Sbjct: 4347 EPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIR---QLGNGS 4403
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
L + E G+YTCVA N+ GV S+ L
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSL 4434
Score = 95.5 bits (236), Expect = 6e-20
Identities = 74/279 (26%), Positives = 116/279 (41%), Gaps = 24/279 (8%)
Query: 37 GTDNITVRQGDTAILRCVVED-KNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95
G ++ + + +L C+ E ++ W ++ H ++S+ LE
Sbjct: 3718 GPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSI-----LENGF----- 3767
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L IQ V D G Y C ++ L V VPP I+ +++TV TL C A
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEA 3827
Query: 156 NGRPEPVITWRHLTPTGREFEGEEEY-------LEILGITREQSGKYECKAANEVSSADV 208
G P+P I WR + + Y L I+ + + + YEC N D
Sbjct: 3828 TGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD-DK 3886
Query: 209 KQVKVTVNYPPTITESKSNEATTGR-QASLKCEASAVPAPDFEWYRDDTR-INSANGLEI 266
+ V +TV PP+I + ++ T A + C AS VP P W ++ R + +G I
Sbjct: 3887 RTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRI 3946
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S+ G + T + H G YTCVA N G + + L
Sbjct: 3947 LSS-GAIEILATQL--NHAGRYTCVARNAAGSAHRHVTL 3982
Score = 94.7 bits (234), Expect = 1e-19
Identities = 67/207 (32%), Positives = 95/207 (45%), Gaps = 8/207 (3%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L+I + D G+Y C Q ++ L VQVPP IS + + +TL C A
Sbjct: 4043 LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA 4102
Query: 156 NGRPEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQV 211
+G P P ITW R + + R+ L+I + +G Y C AAN V+ +
Sbjct: 4103 DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN-VAGSSSTST 4161
Query: 212 KVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
K+TV+ PP I ++ + QA L C A +P P W +D+ + AN L + E
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLL--ANLLGKYTAE 4219
Query: 271 GQSSLTVTNVTEEHYGNYTCVAANKLG 297
L + NV E G YTCVA N G
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAG 4246
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/275 (24%), Positives = 111/275 (40%), Gaps = 22/275 (8%)
Query: 39 DNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
+N+TV G+ A+L C ++ + + W D +P R SL
Sbjct: 527 NNVTVTPGERAVLTCLIISAVDYNLTWQRND------RDVRLAEPA---RIRTLANLSLE 577
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANG 157
++ V D G Y C V ++ + V+L VQ PPK++ + + + GS V+++C A G
Sbjct: 578 LKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATG 637
Query: 158 RPEPVITWRHLTPTGREFEGEEEY-------LEILGITREQSGKYECKAANEVSSADVKQ 210
P+P I W T G Y L I + +G Y C A+N +
Sbjct: 638 YPKPKIAW---TVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694
Query: 211 VKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
+ P + G ++C+ S +P P +W++ D + + L I
Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL 754
Query: 271 GQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
G L + + G+YTCVA N+ G + L
Sbjct: 755 G--LLKIQETQDLDAGDYTCVAINEAGRATGKITL 787
Score = 92.8 bits (229), Expect = 4e-19
Identities = 74/234 (31%), Positives = 112/234 (47%), Gaps = 20/234 (8%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI-VQVPPKI--SNISSDVTVNEGSNVTLV 152
L+I+ V D G YTC T KT + Y + + VPP I S+ + +TV EG+ ++L+
Sbjct: 2159 LKIEDAQVQDTGRYTCEA-TNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLL 2217
Query: 153 CMANGRPEPVITWRHL-TPTGREFEGEEEYL------EILGITREQSGKYECKAANEVSS 205
C ++G P P + W+ +P + G L +I + + Y C A+N +
Sbjct: 2218 CESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277
Query: 206 ADVKQVKVTVNYPPTITESKSNEA----TTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
A K+ + V PTIT S S+ T G+ SL+CE +P P W +D + A
Sbjct: 2278 AK-KEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKA 2336
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA--SLVLFRPGSVRG 313
G+EI EG L + N+ G Y CVA N G+T+ L + P S+ G
Sbjct: 2337 KGVEILD-EGH-ILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIG 2388
Score = 91.7 bits (226), Expect = 9e-19
Identities = 77/250 (30%), Positives = 119/250 (47%), Gaps = 19/250 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQ-VYLIVQVPPKISNISS--DVTVNEGSNVTLV 152
L+I K + D G YTC V T +T Q + L V PP + + + TV + V L
Sbjct: 1883 LQIAKTLLEDAGRYTC-VATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLE 1941
Query: 153 CMANGRPEPVITW----RHLT-PTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C A G P PVITW R L+ T F + ++I +G Y+C A N + +
Sbjct: 1942 CKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATE 2001
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINS-ANGLE 265
+ + V+ P+I+ S + A L+CEA +PAP W +D + ++S +NGL+
Sbjct: 2002 L-FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ 2060
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSVRGINGSISLAVP 323
+ S G L +T+ G YTCVA N G + L ++ P ++ G ++S+ +
Sbjct: 2061 VLS--GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLIS 2118
Query: 324 LWLLAASLLC 333
A LLC
Sbjct: 2119 ---QAVELLC 2125
Score = 91.3 bits (225), Expect = 1e-18
Identities = 64/215 (29%), Positives = 94/215 (43%), Gaps = 16/215 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
LR+ + + D G YTC V+ + L V VPP I N DV V E +VTL C
Sbjct: 2442 LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 154 MANGRPEPVITWRHLTPTGREFEGEE-----EYLEILGITREQSGKYECKAANEVSSADV 208
G P P ITW +E E +L+I + +G+Y C A++
Sbjct: 2502 EVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKS- 2560
Query: 209 KQVKVTVNYPPTI----TESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ + V PTI ++ + T SL CEA + P W++D T + S
Sbjct: 2561 RSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I G +L + N E++ G Y+CVA N+ G
Sbjct: 2621 NIRI--LPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Score = 90.5 bits (223), Expect = 2e-18
Identities = 70/245 (28%), Positives = 106/245 (43%), Gaps = 24/245 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--ISSDVTVNEGSNVTLVC 153
L+I + D G+YTC +L +QVPP ++ I SDV+V G NV LVC
Sbjct: 3209 LQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVC 3268
Query: 154 MANGRPEPVITWRHLTPTGREF-EGEEEY---------LEILGITREQSGKYECKAANEV 203
ANG P P+I W G+ GE E L I G +GKY C A N
Sbjct: 3269 NANGIPTPLIQW---LKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPA 3325
Query: 204 SSADVKQVKVTVNYPPTITESKSNE----ATTGRQASLKCEASAVPAPDFEWYRDDTRIN 259
D + + V PTI +K +++C A+ P P W ++ +
Sbjct: 3326 GEED-RIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLP 3384
Query: 260 SANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA--SLVLFRPGSVRGINGS 317
++ + + + GQ + + YTCVA+N+ GV N +L +F P ++ G+
Sbjct: 3385 LSSHIRLLAA-GQV-IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGT 3442
Query: 318 ISLAV 322
+ V
Sbjct: 3443 EEITV 3447
Score = 90.1 bits (222), Expect = 3e-18
Identities = 62/214 (28%), Positives = 95/214 (44%), Gaps = 15/214 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISS---DVTVNEGSNVTLV 152
L+I + D Y+C + L V + P I+N S ++ V G +++L
Sbjct: 2254 LQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE 2313
Query: 153 CMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C G P P +TW + G E E L++ I +G+Y C A N D
Sbjct: 2314 CEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTD 2373
Query: 208 VKQVKVTVNYPPTIT---ESKSNEATTGRQA-SLKCEASAVPAPDFEWYRDDTRINSANG 263
K+ ++V+ PP+I S N + + + SL CEAS +P P W++D ++ +N
Sbjct: 2374 -KKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNS 2432
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I S G L + T E G YTCV N G
Sbjct: 2433 VRILS--GGRMLRLMQTTMEDAGQYTCVVRNAAG 2464
Score = 89.7 bits (221), Expect = 3e-18
Identities = 71/240 (29%), Positives = 105/240 (43%), Gaps = 17/240 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSD----VTVNEGSNVTL 151
L+I + V D G YTC + + Q + V VPP I +SD VTV + +
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892
Query: 152 VCMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C+++G P P +W+ L +F L+IL G+Y C A N SA
Sbjct: 2893 ECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSA 2952
Query: 207 DVKQVKVTVNYPPTITESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
K + V+ PP++ KS T SL CE S P PD W +++ I
Sbjct: 2953 K-KYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNT 3011
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA--SLVLFRPGSVRGINGSISLAV 322
I G +L + G YTC+A N+ G + SL ++ P S++ + S SL+V
Sbjct: 3012 LI--VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKD-HDSESLSV 3068
Score = 88.6 bits (218), Expect = 7e-18
Identities = 67/230 (29%), Positives = 101/230 (43%), Gaps = 12/230 (5%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
++ I + G YTC + V L V PP I S++ V + + L C
Sbjct: 3951 AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCE 4010
Query: 155 ANGRPEPVITWR----HLTPTGREFEG-EEEYLEILGITREQSGKYECKAANEVSSADVK 209
A G P P ITW+ ++ +GR L+I RE +G Y C A N +A +
Sbjct: 4011 ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTA-LG 4069
Query: 210 QVKVTVNYPPTIT-ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKS 268
++K+ V PP I+ K + +L CEA +P PD W++D I + + S
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLS 4129
Query: 269 TEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSVRGING 316
+ SL + V G+YTC+AAN G T+ L + P +R G
Sbjct: 4130 S---GSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEG 4176
Score = 87.0 bits (214), Expect = 2e-17
Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI--SSDVTVNEGSNVTLVC 153
+RI + V D YTC + L V PP + N + ++TV +GS+ ++ C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 154 MANGRPEPVITW-RHLTPTGRE----FEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
+ +G P P + W R P G + L++L E SGKY C A+NE
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVS- 3516
Query: 209 KQVKVTVNYPPTITESKSNE---ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
K + V PP I S+ +E L C AS +PAP W +D + + +
Sbjct: 3517 KHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTD--Q 3574
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+++ G L ++ E G YTC+A++ G
Sbjct: 3575 VQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/247 (25%), Positives = 105/247 (42%), Gaps = 23/247 (9%)
Query: 62 VAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKT 121
+ W +F G DP VEL R + L ++ D+G Y C+V +
Sbjct: 1485 IHWFKDGKPLFLG------DPNVELLDRGQV---LHLKNARRNDKGRYQCTVSNAAGKQA 1535
Query: 122 SQVYLIVQVPPKIS--NISSDVTVNEGSNVTLVCMANGRPEPVITWRH-----LTPTGRE 174
+ L + +PP I N+++D++V S + L C G P P ITW ++ +
Sbjct: 1536 KDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQAL 1595
Query: 175 FEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTI----TESKSNEAT 230
+ + +YL I S Y C AN +A+ K V V PP I + +
Sbjct: 1596 YIDKGQYLHIPRAQVSDSATYTCHVANVAGTAE-KSFHVDVYVPPMIEGNLATPLNKQVV 1654
Query: 231 TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
+L+C+A+ P+P W +D + + + + I++ G L + + E G Y C
Sbjct: 1655 IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA--GGKKLEIMSAQEIDRGQYIC 1712
Query: 291 VAANKLG 297
VA + G
Sbjct: 1713 VATSVAG 1719
Score = 86.3 bits (212), Expect = 4e-17
Identities = 79/257 (30%), Positives = 105/257 (40%), Gaps = 54/257 (21%)
Query: 78 WSLD--PRVELEKRHSLEYS--LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK 133
W D P E E H + L+I V V G YTC + K+ L V V P
Sbjct: 2513 WHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT 2572
Query: 134 ISNISSD-----VTVNEGSNVTLVCMANGRPEPVITWR------------HLTPTGREFE 176
I+ + SD VTV S +LVC A P ITW + P GR
Sbjct: 2573 IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT-- 2630
Query: 177 GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITES---------KSN 227
L+IL + +G+Y C A NE +K +V V PP I + K
Sbjct: 2631 -----LQILNAQEDNAGRYSCVATNEAGEM-IKHYEVKVYIPPIINKGDLWGPGLSPKEV 2684
Query: 228 EATTGRQASLKCEASAVPAPDFEWYRD------DTRIN-SANGLEIKSTEGQSSLTVTNV 280
+ +L+CEA A+P+ WY+D D +N +ANG ++ E Q S T
Sbjct: 2685 KIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDT---- 2740
Query: 281 TEEHYGNYTCVAANKLG 297
G YTCVA+N G
Sbjct: 2741 -----GRYTCVASNIAG 2752
Score = 86.3 bits (212), Expect = 4e-17
Identities = 66/217 (30%), Positives = 90/217 (41%), Gaps = 20/217 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSN-VTLVCM 154
L I+K +V D G Y C +L V VPP I +V V SN VTL C
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD 3174
Query: 155 ANGRPEPVITWRHLTPTGREFEGEEEYLEI--------LGITREQ---SGKYECKAANEV 203
A G P P I W + E + LE+ L I R Q SG Y C A+N
Sbjct: 3175 ATGIPPPTIAW---LKNHKRIENSDS-LEVRILSGGSKLQIARSQHSDSGNYTCIASNME 3230
Query: 204 SSADVKQVKVTVNYPPTITESKSNEATT---GRQASLKCEASAVPAPDFEWYRDDTRINS 260
A K +++ PP++ ++ + G L C A+ +P P +W +D I S
Sbjct: 3231 GKAQ-KYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS 3289
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
I+ + S+L + G YTCVA N G
Sbjct: 3290 GETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG 3326
Score = 85.1 bits (209), Expect = 8e-17
Identities = 61/217 (28%), Positives = 86/217 (39%), Gaps = 15/217 (6%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
S++I + D G Y C T V L V VPPKI + V G V + C
Sbjct: 1134 SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCN 1193
Query: 155 ANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVK 209
A G P PVITW L + L I T +G Y C A N ++ D
Sbjct: 1194 AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATN-IAGTDET 1252
Query: 210 QVKVTVNYPPTITE------SKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN- 262
++ + V PPT+ + + E ++ C A P P +W + +
Sbjct: 1253 EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP 1312
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
G+ I E + L + +VT G Y CVA N+ G T
Sbjct: 1313 GISI--LEDGTLLVIASVTPYDNGEYICVAVNEAGTT 1347
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/224 (25%), Positives = 96/224 (42%), Gaps = 11/224 (4%)
Query: 89 RHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSN 148
+ S +L I KV + DEG Y C + +Q + V PP + + ++VTV G
Sbjct: 477 KESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGER 536
Query: 149 VTLVCMANGRPEPVITWR------HLTPTGREFEGEEEYLEILGITREQSGKYECKAANE 202
L C+ + +TW+ L R LE+ + +G+Y C ++E
Sbjct: 537 AVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSE 596
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
S+ V +TV PP +T N++ T G + S+ C A+ P P W +D I +
Sbjct: 597 GGSS-AASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + S +L + N + G Y C+A+N G + L
Sbjct: 656 HRYRMTS---DGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Score = 84.3 bits (207), Expect = 1e-16
Identities = 68/217 (31%), Positives = 93/217 (42%), Gaps = 15/217 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L+IQ+ D G YTC + T ++ L V PP +DV++ GSNVTL C
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV 816
Query: 156 NGRPEPVITWRHLTPT---GREF------EGEEEYLEILGITREQSGKYECKAANEVSSA 206
G PEP I WR L R F + L IL + G Y C+A N+
Sbjct: 817 QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKI 876
Query: 207 DVK-QVKVTVNYPPTITESKS-NEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSANG 263
+ V VT P I S S G+Q +L C A P P+ W ++ +
Sbjct: 877 QSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPY 936
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
+ ++S SL + V + G YTCVA+N G N
Sbjct: 937 ITVRS---DGSLHIERVQLQDGGEYTCVASNVAGTNN 970
Score = 83.6 bits (205), Expect = 2e-16
Identities = 62/222 (27%), Positives = 99/222 (44%), Gaps = 18/222 (8%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
SL I++V + D G YTC ++V V P I + ++ EG VTL C
Sbjct: 944 SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003
Query: 155 ANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVK 209
A+G P+P + W T + + G + L ++ E+SG+Y C A N A +
Sbjct: 1004 ASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAK-R 1062
Query: 210 QVKVTVNYPPTI-------TESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINS 260
+V++TV P + ++ K E + G + +L CE ++P P W ++ I+
Sbjct: 1063 KVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISP 1122
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG-VTNA 301
+ G +T T ++ G Y CVA N G VT A
Sbjct: 1123 FSPRHTFLPSGSMKITETRTSDS--GMYLCVATNIAGNVTQA 1162
Score = 83.2 bits (204), Expect = 3e-16
Identities = 64/243 (26%), Positives = 107/243 (44%), Gaps = 22/243 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP------KISNISSDVTVNEGSNV 149
L I V YD G Y C + + L V VPP +++N+S V +N+ +N
Sbjct: 1323 LVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVS--VLLNQLTN- 1379
Query: 150 TLVCMANGRPEPVITWR----HLTPTGR-EFEGEEEYLEILGITREQSGKYECKAANEVS 204
L C G P P+I W +T + + + L++ T E +G+Y CKA N ++
Sbjct: 1380 -LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAIN-IA 1437
Query: 205 SADVKQVKVTVNYPPTITESK-SNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSA 261
K + V PPTI + NE + R +L+C+ P PD W++D +
Sbjct: 1438 GTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG 1497
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSVRGINGSIS 319
+ ++ + L + N G Y C +N G + L ++ P S++G N +
Sbjct: 1498 DP-NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD 1556
Query: 320 LAV 322
++V
Sbjct: 1557 ISV 1559
Score = 82.8 bits (203), Expect = 4e-16
Identities = 69/273 (25%), Positives = 105/273 (38%), Gaps = 25/273 (9%)
Query: 37 GTD---NITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLE 93
GTD +ITV + L C + V R+G ++ PRV +
Sbjct: 3624 GTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNG------ERLQATPRVRILSGGRY- 3676
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVC 153
L+I D+ D +YTC T + L V VPP I + + + L C
Sbjct: 3677 --LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLEC 3734
Query: 154 MANGRPEPVITWRHLTPTGREFEG--------EEEYLEILGITREQSGKYECKAANEVSS 205
+A G P P ITWR G G E +L I +G+Y C A N +
Sbjct: 3735 IAEGVPTPRITWR---KDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN-AAG 3790
Query: 206 ADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
D +++ + V+ PP+I +N Q +L CEA+ +P P W ++ +N
Sbjct: 3791 TDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ 3850
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
SL + + + + Y C N G
Sbjct: 3851 NSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883
Score = 82.0 bits (201), Expect = 7e-16
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 11/219 (5%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS--NISSDVTVNEGSNVTLVC 153
L I D G Y C + K + + V VPP I + +S V + + L C
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 154 MANGRPEPVITWRHLTPTGREFEGEEEYLE-----ILGITREQSGKYECKAANEVSSADV 208
G P P I W E +G + L I +G Y C AAN
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHK- 1815
Query: 209 KQVKVTVNYPPTITESKSNEATTGRQ--ASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
K+ +VTV+ PPTI S +E + +L+C A+ +P P W +DD +N+A G +
Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG-NL 1874
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
K L + E G YTCVA N G T + L
Sbjct: 1875 KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQL 1913
Score = 81.3 bits (199), Expect = 1e-15
Identities = 74/246 (30%), Positives = 106/246 (43%), Gaps = 15/246 (6%)
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVY-LIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
I+ + D G Y C V T Y L V V P IS ++ V V + V L C A
Sbjct: 1978 IESAQISDAGIYKC-VAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEAR 2036
Query: 157 GRPEPVITWRHLTPTGREFEGEEEYL---EILGITREQ---SGKYECKAANEVSSADVKQ 210
G P P +TW F + L IL +T Q +G+Y C A N +
Sbjct: 2037 GIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ-RD 2095
Query: 211 VKVTVNYPPTITESKSNEATTGRQA-SLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
+ + V PP I + N + QA L C++ A+P P W +D + GL I +
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI--S 2153
Query: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLGVT--NASLVLFRPGSVRGINGSISLAVPLWLL 327
E +S L + + + G YTC A N G T N ++ ++ P ++ G + L V L
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNL 2213
Query: 328 AASLLC 333
SLLC
Sbjct: 2214 -ISLLC 2218
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/211 (29%), Positives = 87/211 (41%), Gaps = 13/211 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISS--DVTVNEGSNVTLVC 153
LRI V D G YTC + + + V VPP I+ D+TV VTL C
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643
Query: 154 MANGRPEPVITW------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
++ P PVITW TP R G YL+I + Y C A+N ++
Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVRILSG-GRYLQINNADLGDTANYTCVASN-IAGKT 3701
Query: 208 VKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
++ +TVN PP I +S + L+C A VP P W +D + +
Sbjct: 3702 TREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYS 3761
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
G + +VT+ G Y C+A N G
Sbjct: 3762 ILENGFLHIQSAHVTDT--GRYLCMATNAAG 3790
Score = 80.9 bits (198), Expect = 2e-15
Identities = 56/210 (26%), Positives = 87/210 (41%), Gaps = 9/210 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L + + D G YTC K + L V VPP I +V+V V L+C +
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQS 2127
Query: 156 NGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQ 210
+ P P +TW L G L+I + +G+Y C+A N V+ K
Sbjct: 2128 DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN-VAGKTEKN 2186
Query: 211 VKVTVNYPPTITESKSNEATT---GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
V + PP I S T G SL CE+S +P P+ W + + + + + ++
Sbjct: 2187 YNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVR 2246
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
G L ++ + Y+CVA+N G
Sbjct: 2247 ILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 79.3 bits (194), Expect = 4e-15
Identities = 62/222 (27%), Positives = 98/222 (44%), Gaps = 16/222 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI---SNISSDVTVNEGSNVTLV 152
L+++ + V D G Y C + L V PP I +++V E ++V+L
Sbjct: 2348 LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 153 CMANGRPEPVITWRH------LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A+G P P ITW L+ + R G L ++ T E +G+Y C N +
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR-MLRLMQTTMEDAGQYTCVVRN-AAGE 2465
Query: 207 DVKQVKVTVNYPPTITESKSNEATTGRQ---ASLKCEASAVPAPDFEWYRDDTRINSANG 263
+ K ++V PP I + E ++ +L CE + P P+ W++D +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEA 2525
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
I S G L +TNV H G YTC+A++ G + S L
Sbjct: 2526 HHIIS--GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSL 2565
Score = 72.4 bits (176), Expect = 5e-13
Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 10/208 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS-NISSDVTVNEGSNVTLVCM 154
L I++V D G+Y C+ + + ++ V+ PP + S+ G N L C
Sbjct: 4313 LVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE 4372
Query: 155 ANGRPEPVITWRH----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQ 210
G P P I W + + R + L I G E +G Y C A NE + +
Sbjct: 4373 VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE-RS 4431
Query: 211 VKVTVNYPPTIT-ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
+ +T+ PP IT E G + L C+A+ P P W R I+ + + + S
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLS- 4490
Query: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+SL + + +E + CVA N +G
Sbjct: 4491 --NNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 65.5 bits (158), Expect = 7e-11
Identities = 61/273 (22%), Positives = 108/273 (39%), Gaps = 37/273 (13%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--------ISSDVTVNEG 146
+L+I + G Y+C + + V +PP I+ +V +
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689
Query: 147 SNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY--------LEILGITREQSGKYECK 198
+ +TL C A P ++W G+ + ++ L+I +G+Y C
Sbjct: 2690 NTLTLECEAYAIPSASLSWYK---DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCV 2746
Query: 199 AANEVSSADVKQVKVTVNYPPTITE--SKSNEATTGRQA-----------SLKCEASAVP 245
A+N ++ D V + PP+ + N TGR SL CE +A P
Sbjct: 2747 ASN-IAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAP 2805
Query: 246 APDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA--SL 303
P WY+D + S++ ++ G L + E G YTCVA N+ G + +
Sbjct: 2806 PPTLTWYKDGHPLTSSD--KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDV 2863
Query: 304 VLFRPGSVRGINGSISLAVPLWLLAASLLCLLS 336
+ P ++G N + V + + ++L+ LS
Sbjct: 2864 RVLVPPIIKGANSDLPEEVTVLVNKSALIECLS 2896
Score = 63.5 bits (153), Expect = 3e-10
Identities = 63/225 (28%), Positives = 92/225 (40%), Gaps = 17/225 (7%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQ--VPPKISNISSDVTVNEGSNVTLVC-MANGRPEP 161
D+G+Y C + Q S+ + V V P I S V EG +TL C + G P P
Sbjct: 861 DKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIP 920
Query: 162 VITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNY 217
W L + L I + + G+Y C A+N V+ + K V V+
Sbjct: 921 ERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN-VAGTNNKTTSVVVHV 979
Query: 218 PPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLT 276
PTI + +T G +L C+AS P P W + I++++ +G SL
Sbjct: 980 LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG--SLY 1037
Query: 277 VTNVTEEHYGNYTCVAANKLGVTNASL---VLFRP---GSVRGIN 315
V + E G Y C A N G + V RP G RG++
Sbjct: 1038 VVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS 1082
Score = 59.7 bits (143), Expect = 4e-09
Identities = 70/290 (24%), Positives = 103/290 (35%), Gaps = 34/290 (11%)
Query: 61 KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPK 120
K+AW I H R + + +L I+ D G Y C
Sbjct: 642 KIAWTVNDMFIVGSH-----------RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTD 690
Query: 121 TSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW----RHLTPTGREFE 176
L PK+ + S++ V G + C +G P P + W L P+ F
Sbjct: 691 KQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPS--TFL 748
Query: 177 GEEEYLEILGITREQ---SGKYECKAANEVSSADVKQVKVTVNYPPT-ITESKSNEATTG 232
+ L +L I Q +G Y C A NE A K + + V PP I E G
Sbjct: 749 IIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGK-ITLDVGSPPVFIQEPADVSMEIG 807
Query: 233 RQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEG--QSSLTVTNVTEEHYGNYTC 290
+L C P P +W R D + + S +L + N+ G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 291 VAANKLGVTNASLVLFRPGSVR---GINGSIS-------LAVPLWLLAAS 330
A N+ G + + G V GI+ S++ L +P LLA +
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGN 917
Score = 57.0 bits (136), Expect = 2e-08
Identities = 47/169 (27%), Positives = 67/169 (39%), Gaps = 16/169 (9%)
Query: 46 GDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVY 104
G AIL C V+ D + W NR G+ D + R SL I
Sbjct: 4364 GGNAILNCEVKGDPTPTIQW-NRKGV----------DIEISHRIRQLGNGSLAIYGTVNE 4412
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D G YTC + + L +Q PP I+ + +N G + L C A G P+P IT
Sbjct: 4413 DAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTIT 4472
Query: 165 W----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVK 209
W ++ R L I +E + ++EC A N + S V+
Sbjct: 4473 WSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVR 4521
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 108 bits (270), Expect = 7e-24
Identities = 84/275 (30%), Positives = 125/275 (45%), Gaps = 28/275 (10%)
Query: 40 NITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
N+TV G+TA+L C V+ + + W+ W + P + SL I
Sbjct: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVR----------DWRVLPASTGRVAQLADLSLEI 457
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
+ D G Y C + + V+L+V+ P++S +S ++G V + C A+G
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 517
Query: 159 PEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I+W + L R + L I G+ E +G Y C+A NEV + D + V +
Sbjct: 518 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLY 576
Query: 215 VNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE-IKSTEGQ 272
PP+++ + G +A L CEAS VP P WYR GLE I + EG
Sbjct: 577 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--------GGLEMILAPEGS 628
Query: 273 SS--LTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
SS L + E G YTC A N+LG +A + L
Sbjct: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 87 EKRHSLEY---SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV 143
E+RH E S I + +EG+Y C+ ++ ++ ++V PP + +VTV
Sbjct: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411
Query: 144 NEGSNVTLVCMANGRPEPVIT----WRHL-TPTGREFEGEEEYLEILGITREQSGKYECK 198
+ G L C G +T WR L TGR + + LEI GI G+Y+C
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 471
Query: 199 AANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI 258
A+N + P + S + G + + C AS P P W R+ +
Sbjct: 472 ASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 531
Query: 259 NSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF--RPGSVRGING 316
+ + + + Q +L + V E GNY+C A N++G ++ L+ P SV +N
Sbjct: 532 QEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA 588
Query: 317 SISLAV 322
+ +AV
Sbjct: 589 VVLVAV 594
Score = 89.0 bits (219), Expect = 6e-18
Identities = 86/304 (28%), Positives = 129/304 (42%), Gaps = 27/304 (8%)
Query: 40 NITVRQGDTAILRCVVEDKNSK-VAWLNRSGI-----IFAGHDKWSLDPRVELEKRHSLE 93
++TV G +A+L C + V W G + AG S P +
Sbjct: 677 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV------- 729
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV--QVPPKISNISSDVTVNEGSNVTL 151
L + V D+ Y C + ++ LIV PP+I++ + V V EG V+L
Sbjct: 730 --LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
Query: 152 VCMA-NGRPEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C+ GRP P W R L P R + L + +E +G+Y C A N S
Sbjct: 788 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ 847
Query: 207 DVKQVKVTVNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ V++ V PP I + ++ T G ASL C AS VPAP W ++ + S
Sbjct: 848 H-RDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 906
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVR-GINGSISLAVPL 324
S EG +L + + + G Y C A N +G ++ + L R +NGS + VPL
Sbjct: 907 NVSKEG--TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
Query: 325 WLLA 328
+ A
Sbjct: 965 QVTA 968
Score = 85.9 bits (211), Expect = 5e-17
Identities = 62/216 (28%), Positives = 92/216 (42%), Gaps = 17/216 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
LRI D G+YTC + ++++ L V P+++ + DVTV G + L C A
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692
Query: 156 NGRPEPVITWRH--LTPTG---------REFEGEEEYLEILGITREQSGKYECKAANEVS 204
GRP P +TWR P G R + + L + E Y C+A N
Sbjct: 693 TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 752
Query: 205 SADVK-QVKVTVNYPPTITESKSN-EATTGRQASLKCEASA-VPAPDFEWYRDDTRINSA 261
+ ++ VT + PP I S G+ SL C A P P+ W +D +
Sbjct: 753 KVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG 812
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I++ SL + +EH G Y+CVA N G
Sbjct: 813 SRHSIRA---DGSLHLDRALQEHAGRYSCVATNTAG 845
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 18/232 (7%)
Query: 89 RHSL--EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEG 146
RHS+ + SL + + G Y+C + V L+VQVPP+I ++ NEG
Sbjct: 814 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEG 873
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTGREFE-GEEEYLEILGITREQSGKYECKAAN 201
+L C+A+G P P ITW LT G + +E L I + + +G Y C A N
Sbjct: 874 VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 933
Query: 202 EVSSADVKQVKVTVNYPPTITESKSNEAT--------TGRQASLKCEASAVPAPDFEWYR 253
V + ++++++VN P I + S A G + +L CEA P P W +
Sbjct: 934 TVGFSS-QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK 992
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
D + G SL + V G+Y C A+N G + VL
Sbjct: 993 DSRPVPPITNRYGLLPSG--SLRLAQVQVGDSGHYECTASNPAGSASHRYVL 1042
Score = 83.6 bits (205), Expect = 2e-16
Identities = 68/250 (27%), Positives = 97/250 (38%), Gaps = 21/250 (8%)
Query: 75 HDKWSLDPRVELEKRH---SLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP 131
H WS + + E + +L IQ V D G+Y+C + V L P
Sbjct: 521 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 580
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH------LTPTGREFEGEEEYLEIL 185
P +S +++ V V G LVC A+G P P + W L P G L I
Sbjct: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSGKLRIP 636
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITE-SKSNEATTGRQASLKCEASAV 244
+G Y C+A NE+ A ++++ V + P +TE + GR A L C A+
Sbjct: 637 AAQERDAGTYTCRAVNELGDASA-EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 695
Query: 245 PAPDFEWYRDD-----TRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
P P W R D R+ + G + + L +V E Y C A N G
Sbjct: 696 PPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCEARNVFGKV 754
Query: 300 NASLVLFRPG 309
A L G
Sbjct: 755 QAEARLIVTG 764
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 108 bits (270), Expect = 7e-24
Identities = 84/275 (30%), Positives = 125/275 (45%), Gaps = 28/275 (10%)
Query: 40 NITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
N+TV G+TA+L C V+ + + W+ W + P + SL I
Sbjct: 525 NVTVSPGETAVLSCRVLGEAPYNLTWVR----------DWRVLPASTGRVAQLADLSLEI 574
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
+ D G Y C + + V+L+V+ P++S +S ++G V + C A+G
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 634
Query: 159 PEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I+W + L R + L I G+ E +G Y C+A NEV + D + V +
Sbjct: 635 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLY 693
Query: 215 VNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE-IKSTEGQ 272
PP+++ + G +A L CEAS VP P WYR GLE I + EG
Sbjct: 694 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--------GGLEMILAPEGS 745
Query: 273 SS--LTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
SS L + E G YTC A N+LG +A + L
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780
Score = 100 bits (248), Expect = 2e-21
Identities = 71/249 (28%), Positives = 111/249 (44%), Gaps = 28/249 (11%)
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
+SL L+I+KVD+ DEG YTC+ +V L V VPP I + V E ++V
Sbjct: 1844 YSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASV 1903
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGIT--------------REQSGKY 195
TL C+A+G P P ++W F+G + +G+T +G Y
Sbjct: 1904 TLECLASGVPPPDVSW---------FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 1954
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTIT--ESKSNEATTGRQASLKCEASAVPAPDFEWYR 253
C A+N S +++ + VN PP IT S L C A+ P+P W +
Sbjct: 1955 RCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK 2013
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL--FRPGSV 311
D ++ A ++ G LT+ + G Y+CVA + +G +VL P S+
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 2073
Query: 312 RGINGSISL 320
G ++S+
Sbjct: 2074 LGEELNVSV 2082
Score = 95.1 bits (235), Expect = 8e-20
Identities = 82/309 (26%), Positives = 138/309 (44%), Gaps = 27/309 (8%)
Query: 25 TGLPVRSVDFNRGTDNITVR--------QGDTAILRCVVEDKNSKVAWLNRSGIIFAGHD 76
+G+P ++ + + T+ +T R +G I + +D + V + + F+ +
Sbjct: 1000 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT-VGFSSQE 1058
Query: 77 KWSLDPRVELEKRHSLEY------SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQV 130
R+ L K EY SLR+ +V V D G Y C+ + + L VQV
Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV 1118
Query: 131 PPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH--LTPTGREFEGEEEYLEILGIT 188
PP++ + V G + L C+A G PEP ++W + GR G + + I
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGR---GPQGSVHFAAIR 1175
Query: 189 REQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSN---EATTGRQASLKCEASAVP 245
+G+Y C+A+N + D +V++ V PP +++ E G ASL C A P
Sbjct: 1176 TSDAGRYRCEASNS-AGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTP 1234
Query: 246 APDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN--ASL 303
P W R +G + + SL + +V+ G+Y C A N++G T+ A L
Sbjct: 1235 KPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL 1293
Query: 304 VLFRPGSVR 312
V++ P S+R
Sbjct: 1294 VVYVPPSIR 1302
Score = 92.0 bits (227), Expect = 7e-19
Identities = 65/240 (27%), Positives = 101/240 (42%), Gaps = 32/240 (13%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--ISSDVTVNEGSNVTL 151
+ L++ + D G Y+C + + V VPP I N + + V +G L
Sbjct: 2406 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 2465
Query: 152 VCMANGRPEPVITW------------RHLTPTGREFEGEEEYLEILGITREQSGKYECKA 199
+C G P+P +TW H++P G L++L +G Y C A
Sbjct: 2466 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG-------VLLQVLQANLSSAGHYSCIA 2518
Query: 200 ANEVSSADVKQVKVTVNYPPTITESKSNEA------TTGRQASLKCEASAVPAPDFEWYR 253
AN V K +++V PTI + A T SL CEA A P+P+ W +
Sbjct: 2519 ANAVGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSV 311
D ++ +++ G L + N +E G YTCV N+LG V N + + P S+
Sbjct: 2578 DGAPFEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSI 2635
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 87 EKRHSLEY---SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV 143
E+RH E S I + +EG+Y C+ ++ ++ ++V PP + +VTV
Sbjct: 469 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 528
Query: 144 NEGSNVTLVCMANGRPEPVIT----WRHL-TPTGREFEGEEEYLEILGITREQSGKYECK 198
+ G L C G +T WR L TGR + + LEI GI G+Y+C
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 588
Query: 199 AANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI 258
A+N + P + S + G + + C AS P P W R+ +
Sbjct: 589 ASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 648
Query: 259 NSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF--RPGSVRGING 316
+ + + + Q +L + V E GNY+C A N++G ++ L+ P SV +N
Sbjct: 649 QEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA 705
Query: 317 SISLAV 322
+ +AV
Sbjct: 706 VVLVAV 711
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/215 (30%), Positives = 93/215 (43%), Gaps = 17/215 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
LRI D G+Y C + + L+VQVPP I N D++ EGS+ L C A
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061
Query: 156 NGRPEPVITWRHLTPTGREFEGEE--------EYLEILGITREQSGKYECKAANEVSSAD 207
G PEP ITW G+ G E L + + + +G Y C A N V A
Sbjct: 4062 RGSPEPNITW---DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 4118
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
++V +T+ P T + + G + L+C A P P W +D + +
Sbjct: 4119 -RRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----V 4173
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA 301
+G S+L V+ E G Y C A N++G T A
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 4208
Score = 90.9 bits (224), Expect = 1e-18
Identities = 84/298 (28%), Positives = 122/298 (40%), Gaps = 30/298 (10%)
Query: 39 DNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLE--YSL 96
D + VR GD A+L C + + G P V ++ +L L
Sbjct: 3040 DAVLVRVGDKAVLSCETDALPEPTVTWYKDG-----------QPLVLAQRTQALRGGQRL 3088
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE--GSNVTLVCM 154
IQ+ V D+G Y+C V L VQVPP N ++ TV++ GS + L C
Sbjct: 3089 EIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE-TVSQVAGSPLVLTCD 3147
Query: 155 ANGRPEPVITWR--HLTPTGREFEGEEEY---LEILGITREQSGKYECKAANEVSSADVK 209
+G P P +TW + G L++ + Q+G Y C A N + A K
Sbjct: 3148 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-K 3206
Query: 210 QVKVTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
V V P I S + + G++ L CEA P PD W +D + + G +
Sbjct: 3207 DFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL 3266
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL----VLFRPGSVRGINGSISL 320
+ SL + + G YTCVA N G +A L VL P +G +GS +L
Sbjct: 3267 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTL 3323
Score = 88.2 bits (217), Expect = 1e-17
Identities = 67/237 (28%), Positives = 102/237 (43%), Gaps = 36/237 (15%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS-------SDVTVNEG 146
+ L+I D G YTC V + ++ V +PP IS +V
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTGR-EFEGEEEYLEILGITREQSGKYECKAAN 201
S +TL C + P P I W + +TP+ R + GE L+I SG+Y C A N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 202 EVSSADVKQVKVTVNYPPTITE-----------SKSNEATTG----------RQASLKCE 240
V+ D + V + PP + S+ EA G A L C+
Sbjct: 2715 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+A+P PD WYR+D +++ G E+ +G L + V E+ G Y+C A+N++G
Sbjct: 2774 TNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/213 (31%), Positives = 100/213 (46%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
LRI V DEG Y C + + L V PP I SN + +V V E V L+C
Sbjct: 1465 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLC 1524
Query: 154 MANGRPEPVITW---RHLTPTGRE--FEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
A G P P ITW L PT + + L++ +G Y CKA+N V +A+
Sbjct: 1525 EARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE- 1583
Query: 209 KQVKVTVNYPPTITESKSN----EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
K ++ V PPTI + +A GR +L+C A P+P W+ + + +N
Sbjct: 1584 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 1643
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
++ T+G S L + + E G Y+CVA++ G
Sbjct: 1644 RLE-TDG-SVLRLESPGEASSGLYSCVASSPAG 1674
Score = 86.7 bits (213), Expect = 3e-17
Identities = 62/204 (30%), Positives = 87/204 (42%), Gaps = 24/204 (11%)
Query: 107 GSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWR 166
G YTCS + V+L VQ P + + S V V L C A+G P P ITW+
Sbjct: 3923 GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ 3982
Query: 167 ------------HLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
+ P G+ L I + E +G Y C A N SA + + ++
Sbjct: 3983 KEGLNVATGVSTQVLPGGQ--------LRIAHASPEDAGNYLCIAKNSAGSA-MGKTRLV 4033
Query: 215 VNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
V PP I + +TT G A L C+A P P+ W +D ++ A G G+
Sbjct: 4034 VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE- 4092
Query: 274 SLTVTNVTEEHYGNYTCVAANKLG 297
L V N+ + G YTC A N +G
Sbjct: 4093 -LLVKNLEGQDAGTYTCTAENAVG 4115
Score = 86.3 bits (212), Expect = 4e-17
Identities = 81/303 (26%), Positives = 122/303 (40%), Gaps = 50/303 (16%)
Query: 41 ITVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQ 99
+ V G+ L CV E + +++W ++ G++ G + S+
Sbjct: 1129 LKVLVGEALDLNCVAEGNPEPQLSW-SKDGVVLQGRGP---------------QGSVHFA 1172
Query: 100 KVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK--ISNISSDVTVNEGSNVTLVCMANG 157
+ D G Y C +V L V PP S + G N +L C A G
Sbjct: 1173 AIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARG 1232
Query: 158 RPEPVITWRHLTPTGREFEG-------EEEYLEILGITREQSGKYECKAANEVSSADVKQ 210
P+P +TWR P+ G EE L + ++ SG YEC+A NEV S ++
Sbjct: 1233 TPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS-RR 1290
Query: 211 VKVTVNYPPTITES--KSN-EATTGRQASLKCEASAVPAPDFEWYRD------------- 254
K+ V PP+I E K+N G+ +L+C+A+ P P+ W +D
Sbjct: 1291 AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 1350
Query: 255 --DTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS--LVLFRPGS 310
D G + EGQ SL + E G Y+C A N+ G L++ P S
Sbjct: 1351 GWDLGWGQVGGHRLLD-EGQ-SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 1408
Query: 311 VRG 313
V G
Sbjct: 1409 VLG 1411
Score = 85.9 bits (211), Expect = 5e-17
Identities = 62/216 (28%), Positives = 92/216 (42%), Gaps = 17/216 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
LRI D G+YTC + ++++ L V P+++ + DVTV G + L C A
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 809
Query: 156 NGRPEPVITWRH--LTPTG---------REFEGEEEYLEILGITREQSGKYECKAANEVS 204
GRP P +TWR P G R + + L + E Y C+A N
Sbjct: 810 TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 869
Query: 205 SADVK-QVKVTVNYPPTITESKSN-EATTGRQASLKCEASA-VPAPDFEWYRDDTRINSA 261
+ ++ VT + PP I S G+ SL C A P P+ W +D +
Sbjct: 870 KVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG 929
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I++ SL + +EH G Y+CVA N G
Sbjct: 930 SRHSIRA---DGSLHLDRALQEHAGRYSCVATNTAG 962
Score = 85.5 bits (210), Expect = 6e-17
Identities = 78/280 (27%), Positives = 118/280 (42%), Gaps = 26/280 (9%)
Query: 40 NITVRQGDTAILRCVVEDKNSK-VAWLNRSGI-----IFAGHDKWSLDPRVELEKRHSLE 93
++TV G +A+L C + V W G + AG S P +
Sbjct: 794 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV------- 846
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV--QVPPKISNISSDVTVNEGSNVTL 151
L + V D+ Y C + ++ LIV PP+I++ + V V EG V+L
Sbjct: 847 --LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 904
Query: 152 VCMA-NGRPEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C+ GRP P W R L P R + L + +E +G+Y C A N S
Sbjct: 905 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ 964
Query: 207 DVKQVKVTVNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ V++ V PP I + ++ T G ASL C AS VPAP W ++ + S
Sbjct: 965 H-RDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 1023
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S EG +L + + + G Y C A N +G ++ + L
Sbjct: 1024 NVSKEG--TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 1061
Score = 84.7 bits (208), Expect = 1e-16
Identities = 71/240 (29%), Positives = 103/240 (42%), Gaps = 27/240 (11%)
Query: 78 WSLDPRVELEKRHSLEYS-----LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP 132
W D R LE R + S L++ + DV+D G YTC Q L V V P
Sbjct: 2104 WWKDGR-PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 2162
Query: 133 KIS-NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITRE- 190
S +TV EG +L C G P P I+WR G+ GE L+ +
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK---DGQPLPGEGAGLQHVSAVGRL 2219
Query: 191 ---------QSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTG----RQASL 237
Q G Y C+ +N V ++ + +++ V+ PP I + A+L
Sbjct: 2220 LYLGQAQLAQEGTYTCECSNVVGNSS-QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 2278
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+C A+ P P W RD + + GL++++ +GQ SL V H G Y+CVA N G
Sbjct: 2279 ECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQ-SLHVERAQAAHTGRYSCVAENLAG 2336
Score = 83.6 bits (205), Expect = 2e-16
Identities = 68/250 (27%), Positives = 97/250 (38%), Gaps = 21/250 (8%)
Query: 75 HDKWSLDPRVELEKRH---SLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP 131
H WS + + E + +L IQ V D G+Y+C + V L P
Sbjct: 638 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 697
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH------LTPTGREFEGEEEYLEIL 185
P +S +++ V V G LVC A+G P P + W L P G L I
Sbjct: 698 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSGKLRIP 753
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITE-SKSNEATTGRQASLKCEASAV 244
+G Y C+A NE+ A ++++ V + P +TE + GR A L C A+
Sbjct: 754 AAQERDAGTYTCRAVNELGDASA-EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 812
Query: 245 PAPDFEWYRDD-----TRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
P P W R D R+ + G + + L +V E Y C A N G
Sbjct: 813 PPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-SGVLFFESVAPEDQAPYVCEARNVFGKV 871
Query: 300 NASLVLFRPG 309
A L G
Sbjct: 872 QAEARLIVTG 881
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/274 (27%), Positives = 114/274 (41%), Gaps = 29/274 (10%)
Query: 37 GTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95
G+ + R G+ + C V V+WL + G+ P + H ++
Sbjct: 3319 GSGTLVSRPGELVTMVCPVRGSPPIHVSWL-KDGLPL---------PLSQRTLLHGSGHT 3368
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI--SSDVTVNEGSNVTLVC 153
LRI KV + D G +TC + L VQVPP + + +DV V GS V L C
Sbjct: 3369 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 3428
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK 212
A G P P+++W + P + + L++ + SG Y C A +E A + +
Sbjct: 3429 EARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQ 3487
Query: 213 VTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
+TV PP I +S T G L C+A P P+ W++D G +
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD--------GQALTRL 3539
Query: 270 EGQSSLT-VTNVTEEHYGNYTCVAANKLGVTNAS 302
E S T V V + G YTC+A + G S
Sbjct: 3540 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKS 3571
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/278 (27%), Positives = 119/278 (42%), Gaps = 30/278 (10%)
Query: 40 NITVRQGDTAILRCVVEDKNSK-VAWLNRSGIIFAGHDKWSLDPRVELEKRHSL--EYSL 96
N++V Q TA+L C + + V+W D+ LDPR R + E SL
Sbjct: 3683 NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVPLDPR---SPRFEILPEGSL 3728
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
RIQ V D G Y C L V PP I+ S++T+ + L C A+
Sbjct: 3729 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 3788
Query: 157 GRPEPVITWRHLTPTGREFEGEEEYLEILGITR--------EQSGKYECKAANEVSSADV 208
G P+P++ W +F ++ +L + S ++EC +NEV A
Sbjct: 3789 GSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH- 3846
Query: 209 KQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ +VTV+ PPTI + +++ T L C ++ +PAP W + ++ +
Sbjct: 3847 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 3906
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S G +L + H G YTC A N GV + + L
Sbjct: 3907 SPSG--ALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942
Score = 82.8 bits (203), Expect = 4e-16
Identities = 73/291 (25%), Positives = 125/291 (42%), Gaps = 26/291 (8%)
Query: 36 RGTDNITVRQGDTAILRCVVEDKN-SKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
R + +TVR+G L C K++W + G G L+ ++
Sbjct: 2167 RESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGEG-------AGLQHVSAVGR 2218
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS---SDVTVNEGSNVTL 151
L + + + EG+YTC + + L V VPP+I+ + V+V + TL
Sbjct: 2219 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 2278
Query: 152 VCMANGRPEPVITW-RHLTPTGREF----EGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G+P P +TW R P G E + + + L + +G+Y C A N A
Sbjct: 2279 ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338
Query: 207 DVKQVKVTVNYPPTITES----KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ ++ +++V PP + + A +L CEA +P P W+R + ++
Sbjct: 2339 E-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP-- 2395
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT--NASLVLFRPGSV 311
G + G L +T E+ G Y+C+A+N+ G N S+ + P S+
Sbjct: 2396 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 2446
Score = 81.6 bits (200), Expect = 9e-16
Identities = 71/269 (26%), Positives = 103/269 (38%), Gaps = 27/269 (10%)
Query: 39 DNITVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
+ +T + L C V N +V W S + G + + L ++L+
Sbjct: 2945 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT----------HTLQ 2994
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI----SSDVTVNEGSNVTLVC 153
+ + + D G YTC V L V VPP V V G L C
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 3054
Query: 154 MANGRPEPVITWRH------LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
+ PEP +TW L + G + LEI G Y CK +N V+
Sbjct: 3055 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSN-VAGEA 3112
Query: 208 VKQVKVTVNYPPTITESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
V+ +TV PPT K+ + G L C+ S VPAP W +D + S+
Sbjct: 3113 VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHG 3172
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAAN 294
+ S G+ L ++ + G YTCVA N
Sbjct: 3173 VVSRGGR--LQLSRLQPAQAGTYTCVAEN 3199
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 14/219 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSD---VTVNEGSNVTLV 152
L++ + D G YTC L V VPP I V G V L
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 1617
Query: 153 CMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C+A G P P ++W H E + L + SG Y C A++ A
Sbjct: 1618 CVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA- 1676
Query: 208 VKQVKVTVNYPPTITESKS-NEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
V Q V V PP + ++ + TT G+ L C+AS P P +W ++ G+
Sbjct: 1677 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 1736
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
++ S ++L + +V +H G + C A N+ G A +
Sbjct: 1737 QVASQ--GTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773
Score = 79.0 bits (193), Expect = 6e-15
Identities = 67/255 (26%), Positives = 109/255 (42%), Gaps = 18/255 (7%)
Query: 50 ILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGS 108
+L C VE + + K+ W +R GI+ D + +R L++Q + D G
Sbjct: 3600 VLECSVEAEPAPKITW-HRDGIVLQE------DAHTQFPERGRF---LQLQALSTADSGD 3649
Query: 109 YTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH- 167
Y+C+ + + + + P I + V V+ L C A+G P P+++WR
Sbjct: 3650 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Query: 168 ---LTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITE 223
L P FE E L I + + +G Y C A+N S D + + V PP I
Sbjct: 3710 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS-DRQGRDLRVLEPPAIAP 3768
Query: 224 SKSNEATTGR-QASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTE 282
S SN T A L CEAS P P W++D +++ ++L +T
Sbjct: 3769 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP 3828
Query: 283 EHYGNYTCVAANKLG 297
+ + CV +N++G
Sbjct: 3829 QDSAQFECVVSNEVG 3843
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 10/199 (5%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D + C V + + V VPP I++ +D TV + V L C + G P P ++
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889
Query: 165 W----RHLTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W L G + LEI +G+Y C A N A K V +TV P
Sbjct: 3890 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASP 3948
Query: 220 TITESKS-NEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVT 278
+ S A + L CEAS +P P W ++ +N A G+ + G L +
Sbjct: 3949 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPG-GQLRIA 4005
Query: 279 NVTEEHYGNYTCVAANKLG 297
+ + E GNY C+A N G
Sbjct: 4006 HASPEDAGNYLCIAKNSAG 4024
Score = 77.0 bits (188), Expect = 2e-14
Identities = 60/213 (28%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI----SNISSDVTVNEGSNVTL 151
L+I V + G Y+C + L+V PP I + +VTVN S V+L
Sbjct: 2806 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 2865
Query: 152 VCMANGRPEPVITWRH----LTPTGR-EFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G P P I+W +P+ R + + + L++ + Y C A N+ SA
Sbjct: 2866 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925
Query: 207 DVKQVKVTVNYPPTITESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
+ K + V PP I + T SL C+ A P P+ WY+D ++ G
Sbjct: 2926 E-KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL--GE 2982
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
E+ G +L + G YTC A N G
Sbjct: 2983 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 3015
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 78 WSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--S 135
W D L + SL+++ V D G+Y+C ++ L V PP I S
Sbjct: 3440 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499
Query: 136 NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKY 195
+++++ G+ + L+C A G P+P ITW E +L + +G Y
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV--RDAGLY 3557
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGR---QASLKCEASAVPAPDFEWY 252
C A + + + K +V V PP I + G Q L+C A PAP W+
Sbjct: 3558 TCLAESPAGAIE-KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWH 3616
Query: 253 RDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
RD I + E L + ++ G+Y+C A N G T+ +
Sbjct: 3617 RDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 3664
Score = 75.5 bits (184), Expect = 6e-14
Identities = 70/285 (24%), Positives = 115/285 (40%), Gaps = 23/285 (8%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
++R GD LRC + R G W+++ R E + +Q+
Sbjct: 4139 SLRLGDRLWLRCAARGSPTP-----RIG--------WTVNDRPVTEGVSEQDGGSTLQRA 4185
Query: 102 DVY--DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE-GSNVTLVCMANGR 158
V D G+Y C + + + ++ V+ P + + V G ++ L C+ G
Sbjct: 4186 AVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 4245
Query: 159 PEPVITWRH----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I W L + + + L I R+ +G+Y+C A NE+ A + V
Sbjct: 4246 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 4305
Query: 215 VNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSS 274
+ P E + +G +L+C+A+ P P EW + + ++ L T S
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR---TLPDGS 4362
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSIS 319
L + NV G Y CVA N LG A L G +G GS++
Sbjct: 4363 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 4407
Score = 73.9 bits (180), Expect = 2e-13
Identities = 66/257 (25%), Positives = 98/257 (38%), Gaps = 29/257 (11%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVN--EGSNVT 150
E SL + V D G Y C + + + L+V VPP I V+ G ++T
Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319
Query: 151 LVCMANGRPEPVITWRHLTPT--------------------GREFEGEEEYLEILGITRE 190
L C ANG P P I W G E + L I
Sbjct: 1320 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 1379
Query: 191 QSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEAT---TGRQASLKCEASAVPAP 247
SG Y C+A N+ +A + + V PP++ + + + G L+C S VP P
Sbjct: 1380 DSGLYSCRAENQAGTAQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTP 1438
Query: 248 DFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVL 305
EW +D + G ++ E L +T G Y CVA + G + L +
Sbjct: 1439 QVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Query: 306 FRPGSVRGINGSISLAV 322
P ++ G N + +AV
Sbjct: 1498 HAPPTIWGSNETGEVAV 1514
Score = 73.6 bits (179), Expect = 2e-13
Identities = 64/217 (29%), Positives = 96/217 (44%), Gaps = 20/217 (9%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTL 151
SL +++ G Y+C + + L V VPP++ + +++T S +TL
Sbjct: 2313 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTL 2372
Query: 152 VCMANGRPEPVITW-RHLTPTGREFEGEEEYL----EILGITREQ---SGKYECKAANEV 203
+C A G P P I W R P GE+ YL +L +T+ Q SG Y C A+NE
Sbjct: 2373 LCEAMGIPPPAIRWFRGEEPVS---PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429
Query: 204 SSADVKQVKVTVNYPPTITESKSNE---ATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
A + V V PP+I E G+ A L C + P P W++D +
Sbjct: 2430 GEAR-RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 2488
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I S +G L V G+Y+C+AAN +G
Sbjct: 2489 GDAHHI-SPDG-VLLQVLQANLSSAGHYSCIAANAVG 2523
Score = 72.8 bits (177), Expect = 4e-13
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 10/209 (4%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D G Y+C + V L V +PP I +V+V +V L C ++ P PV++
Sbjct: 2044 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103
Query: 165 W----RHLTP-TGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W R L P G ++ L++ +G Y C+A N+ ++ K + V P
Sbjct: 2104 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSE-KHYNLNVWVAP 2162
Query: 220 T--ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI-NSANGLEIKSTEGQSSLT 276
+ ES + G SL CE VP P W +D + GL+ S G+ L
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 2221
Query: 277 VTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ G YTC +N +G ++ L L
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVGNSSQDLQL 2250
Score = 69.3 bits (168), Expect = 5e-12
Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 16/223 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
L++ ++ G+YTC + + V V P+I S ++ + V EG V L C
Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 3239
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEY------LEILGITREQSGKYECKAANEVSSA 206
A+G+P P + W + +P G++ + L + G+ +G Y C A N
Sbjct: 3240 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGE- 3298
Query: 207 DVKQVKVTVNYPPTITESKSNEATT----GRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
D + V V PPTI + T G ++ C P W +D + +
Sbjct: 3299 DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ 3358
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + +L ++ V G +TCVAA+ GV + + L
Sbjct: 3359 RTLLHGSG--HTLRISKVQLADAGIFTCVAASPAGVADRNFTL 3399
Score = 68.9 bits (167), Expect = 6e-12
Identities = 68/271 (25%), Positives = 97/271 (35%), Gaps = 70/271 (25%)
Query: 89 RHSL--EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEG 146
RHS+ + SL + + G Y+C + V L+VQVPP+I ++ NEG
Sbjct: 931 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEG 990
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTGREF----EGE-------------------- 178
+L C+A+G P P ITW LT G + EG
Sbjct: 991 VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 179 -----------------------EEY-------LEILGITREQSGKYECKAANEVSSADV 208
EEY L + + SG YEC A+N SA
Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110
Query: 209 KQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ V + V PP + + + G L C A P P W +D G+ ++
Sbjct: 1111 RYV-LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKD--------GVVLQ 1161
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
Q S+ + G Y C A+N GV
Sbjct: 1162 GRGPQGSVHFAAIRTSDAGRYRCEASNSAGV 1192
Score = 33.1 bits (74), Expect = 0.36
Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 16/120 (13%)
Query: 15 VLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFA 73
V +++ L+ PV V+ ++TVR GD LRC + + WL +
Sbjct: 4296 VAKKVVILVLQSAPVFQVE----PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL-- 4349
Query: 74 GHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK 133
R R + SL ++ V+ D G+Y C T++ +L+V+ P+
Sbjct: 4350 ---------RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 108 bits (270), Expect = 7e-24
Identities = 84/275 (30%), Positives = 125/275 (45%), Gaps = 28/275 (10%)
Query: 40 NITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
N+TV G+TA+L C V+ + + W+ W + P + SL I
Sbjct: 524 NVTVSPGETAVLSCRVLGEAPYNLTWVR----------DWRVLPASTGRVAQLADLSLEI 573
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
+ D G Y C + + V+L+V+ P++S +S ++G V + C A+G
Sbjct: 574 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 633
Query: 159 PEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I+W + L R + L I G+ E +G Y C+A NEV + D + V +
Sbjct: 634 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLY 692
Query: 215 VNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE-IKSTEGQ 272
PP+++ + G +A L CEAS VP P WYR GLE I + EG
Sbjct: 693 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--------GGLEMILAPEGS 744
Query: 273 SS--LTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
SS L + E G YTC A N+LG +A + L
Sbjct: 745 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 87 EKRHSLEY---SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV 143
E+RH E S I + +EG+Y C+ ++ ++ ++V PP + +VTV
Sbjct: 468 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 527
Query: 144 NEGSNVTLVCMANGRPEPVIT----WRHL-TPTGREFEGEEEYLEILGITREQSGKYECK 198
+ G L C G +T WR L TGR + + LEI GI G+Y+C
Sbjct: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 587
Query: 199 AANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI 258
A+N + P + S + G + + C AS P P W R+ +
Sbjct: 588 ASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 647
Query: 259 NSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF--RPGSVRGING 316
+ + + + Q +L + V E GNY+C A N++G ++ L+ P SV +N
Sbjct: 648 QEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA 704
Query: 317 SISLAV 322
+ +AV
Sbjct: 705 VVLVAV 710
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 107 bits (267), Expect = 2e-23
Identities = 67/227 (29%), Positives = 106/227 (46%), Gaps = 21/227 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I+KVD DE Y C + + + + ++L V PKI+ + + + VTL C A
Sbjct: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
Query: 156 NGRPEPVITWRHLTPTGREFEGEEEYLE---------------ILGITREQSGKYECKAA 200
+G P P ITWR T R EE+ L+ + I +G+Y C A+
Sbjct: 332 SGDPIPSITWRTST---RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
Query: 201 NEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
N + D + + + V Y P + + G Q ++ CE A P+ W+RD + S
Sbjct: 389 NTIGQ-DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS 447
Query: 261 AN--GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+N ++I +T S L VT +E +GNY C A N++G + +L
Sbjct: 448 SNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
Score = 92.0 bits (227), Expect = 7e-19
Identities = 79/284 (27%), Positives = 123/284 (43%), Gaps = 35/284 (12%)
Query: 44 RQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVD 102
R+G+ A++ C VV + W ++ + D + L + L+I+ +
Sbjct: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNY-----LQIRGIK 180
Query: 103 VYDEGSYTCS--VQTQHEPKTSQVYLIVQVPPKISNISSDV--TVNEGSNVTLVCMANGR 158
DEG+Y C + + E + +IV VPP I + V T N G +VTLVC A G
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 159 PEPVITWRHLTPTGREFEGEEE-----------YLEILGITREQSGKYECKAANEVSSAD 207
PEP ++W T G + E EE+ L I + + +Y C A N+ D
Sbjct: 241 PEPTMSW---TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSA----- 261
+ + V P IT ++ A Q +L CEAS P P W I+S
Sbjct: 298 A-TIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLD 356
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ ++S SSLT+ ++ G Y C A+N +G + S+ L
Sbjct: 357 GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/228 (21%), Positives = 82/228 (35%), Gaps = 14/228 (6%)
Query: 88 KRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGS 147
+ H+ SL ++ + D G Y C+ + +YL VQ PK+ + V EG+
Sbjct: 362 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGN 420
Query: 148 NVTLVCMANGRPEPVITW---RHLTPTGREFE------GEEEYLEILGITREQSGKYECK 198
V + C P I+W L P+ YLE+ + G Y C
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 199 AANEVSSADVKQVKVTVNYP--PTITESKSNEATTGRQASLKCEASAVPAPDF--EWYRD 254
A N + ++ + V + P P+I + + +T Q VP + EW
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 255 DTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+ + + K + +T+ + E A N G+ S
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 107 bits (267), Expect = 2e-23
Identities = 67/227 (29%), Positives = 106/227 (46%), Gaps = 21/227 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I+KVD DE Y C + + + + ++L V PKI+ + + + VTL C A
Sbjct: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
Query: 156 NGRPEPVITWRHLTPTGREFEGEEEYLE---------------ILGITREQSGKYECKAA 200
+G P P ITWR T R EE+ L+ + I +G+Y C A+
Sbjct: 332 SGDPIPSITWRTST---RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
Query: 201 NEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
N + D + + + V Y P + + G Q ++ CE A P+ W+RD + S
Sbjct: 389 NTIGQ-DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS 447
Query: 261 AN--GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+N ++I +T S L VT +E +GNY C A N++G + +L
Sbjct: 448 SNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
Score = 92.0 bits (227), Expect = 7e-19
Identities = 79/284 (27%), Positives = 123/284 (43%), Gaps = 35/284 (12%)
Query: 44 RQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVD 102
R+G+ A++ C VV + W ++ + D + L + L+I+ +
Sbjct: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNY-----LQIRGIK 180
Query: 103 VYDEGSYTCS--VQTQHEPKTSQVYLIVQVPPKISNISSDV--TVNEGSNVTLVCMANGR 158
DEG+Y C + + E + +IV VPP I + V T N G +VTLVC A G
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 159 PEPVITWRHLTPTGREFEGEEE-----------YLEILGITREQSGKYECKAANEVSSAD 207
PEP ++W T G + E EE+ L I + + +Y C A N+ D
Sbjct: 241 PEPTMSW---TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSA----- 261
+ + V P IT ++ A Q +L CEAS P P W I+S
Sbjct: 298 A-TIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLD 356
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ ++S SSLT+ ++ G Y C A+N +G + S+ L
Sbjct: 357 GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/228 (21%), Positives = 82/228 (35%), Gaps = 14/228 (6%)
Query: 88 KRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGS 147
+ H+ SL ++ + D G Y C+ + +YL VQ PK+ + V EG+
Sbjct: 362 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGN 420
Query: 148 NVTLVCMANGRPEPVITW---RHLTPTGREFE------GEEEYLEILGITREQSGKYECK 198
V + C P I+W L P+ YLE+ + G Y C
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 199 AANEVSSADVKQVKVTVNYP--PTITESKSNEATTGRQASLKCEASAVPAPDF--EWYRD 254
A N + ++ + V + P P+I + + +T Q VP + EW
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 255 DTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+ + + K + +T+ + E A N G+ S
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 102 bits (254), Expect = 5e-22
Identities = 67/237 (28%), Positives = 105/237 (44%), Gaps = 31/237 (13%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I+KVD DE Y C + + + + ++L V PKI+ + + + VTL C A
Sbjct: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
Query: 156 NGRPEPVITWRHLTPTGREFEGEEE-------------------------YLEILGITRE 190
+G P P ITWR T R EE+ L + I
Sbjct: 332 SGDPIPSITWRTST---RNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT 388
Query: 191 QSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFE 250
+G+Y C A+N + D + + + V Y P + + G Q ++ CE A P+
Sbjct: 389 DAGEYICTASNTIGQ-DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 447
Query: 251 WYRDDTRINSAN--GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
W+RD + S+N ++I +T S L VT +E +GNY C A N++G + +L
Sbjct: 448 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
Score = 88.2 bits (217), Expect = 1e-17
Identities = 79/294 (26%), Positives = 123/294 (41%), Gaps = 45/294 (15%)
Query: 44 RQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVD 102
R+G+ A++ C VV + W ++ + D + L + L+I+ +
Sbjct: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNY-----LQIRGIK 180
Query: 103 VYDEGSYTCS--VQTQHEPKTSQVYLIVQVPPKISNISSDV--TVNEGSNVTLVCMANGR 158
DEG+Y C + + E + +IV VPP I + V T N G +VTLVC A G
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 159 PEPVITWRHLTPTGREFEGEEE-----------YLEILGITREQSGKYECKAANEVSSAD 207
PEP ++W T G + E EE+ L I + + +Y C A N+ D
Sbjct: 241 PEPTMSW---TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSA----- 261
+ + V P IT ++ A Q +L CEAS P P W I+S
Sbjct: 298 A-TIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASW 356
Query: 262 ----------NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ ++S SSLT+ ++ G Y C A+N +G + S+ L
Sbjct: 357 TRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 410
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/228 (21%), Positives = 82/228 (35%), Gaps = 14/228 (6%)
Query: 88 KRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGS 147
+ H+ SL ++ + D G Y C+ + +YL VQ PK+ + V EG+
Sbjct: 372 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGN 430
Query: 148 NVTLVCMANGRPEPVITW---RHLTPTGREFE------GEEEYLEILGITREQSGKYECK 198
V + C P I+W L P+ YLE+ + G Y C
Sbjct: 431 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
Query: 199 AANEVSSADVKQVKVTVNYP--PTITESKSNEATTGRQASLKCEASAVPAPDF--EWYRD 254
A N + ++ + V + P P+I + + +T Q VP + EW
Sbjct: 491 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 550
Query: 255 DTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+ + + K + +T+ + E A N G+ S
Sbjct: 551 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 598
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 100 bits (248), Expect = 2e-21
Identities = 71/249 (28%), Positives = 111/249 (44%), Gaps = 28/249 (11%)
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
+SL L+I+KVD+ DEG YTC+ +V L V VPP I + V E ++V
Sbjct: 653 YSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASV 712
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGIT--------------REQSGKY 195
TL C+A+G P P ++W F+G + +G+T +G Y
Sbjct: 713 TLECLASGVPPPDVSW---------FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 763
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTIT--ESKSNEATTGRQASLKCEASAVPAPDFEWYR 253
C A+N S +++ + VN PP IT S L C A+ P+P W +
Sbjct: 764 RCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK 822
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL--FRPGSV 311
D ++ A ++ G LT+ + G Y+CVA + +G +VL P S+
Sbjct: 823 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 882
Query: 312 RGINGSISL 320
G ++S+
Sbjct: 883 LGEELNVSV 891
Score = 92.0 bits (227), Expect = 7e-19
Identities = 65/240 (27%), Positives = 101/240 (42%), Gaps = 32/240 (13%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--ISSDVTVNEGSNVTL 151
+ L++ + D G Y+C + + V VPP I N + + V +G L
Sbjct: 1215 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 1274
Query: 152 VCMANGRPEPVITW------------RHLTPTGREFEGEEEYLEILGITREQSGKYECKA 199
+C G P+P +TW H++P G L++L +G Y C A
Sbjct: 1275 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG-------VLLQVLQANLSSAGHYSCIA 1327
Query: 200 ANEVSSADVKQVKVTVNYPPTITESKSNEA------TTGRQASLKCEASAVPAPDFEWYR 253
AN V K +++V PTI + A T SL CEA A P+P+ W +
Sbjct: 1328 ANAVGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSV 311
D ++ +++ G L + N +E G YTCV N+LG V N + + P S+
Sbjct: 1387 DGAPFEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSI 1444
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/215 (30%), Positives = 93/215 (43%), Gaps = 17/215 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
LRI D G+Y C + + L+VQVPP I N D++ EGS+ L C A
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870
Query: 156 NGRPEPVITWRHLTPTGREFEGEE--------EYLEILGITREQSGKYECKAANEVSSAD 207
G PEP ITW G+ G E L + + + +G Y C A N V A
Sbjct: 2871 RGSPEPNITW---DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 2927
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
++V +T+ P T + + G + L+C A P P W +D + +
Sbjct: 2928 -RRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----V 2982
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA 301
+G S+L V+ E G Y C A N++G T A
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 3017
Score = 90.9 bits (224), Expect = 1e-18
Identities = 84/298 (28%), Positives = 122/298 (40%), Gaps = 30/298 (10%)
Query: 39 DNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLE--YSL 96
D + VR GD A+L C + + G P V ++ +L L
Sbjct: 1849 DAVLVRVGDKAVLSCETDALPEPTVTWYKDG-----------QPLVLAQRTQALRGGQRL 1897
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE--GSNVTLVCM 154
IQ+ V D+G Y+C V L VQVPP N ++ TV++ GS + L C
Sbjct: 1898 EIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE-TVSQVAGSPLVLTCD 1956
Query: 155 ANGRPEPVITWR--HLTPTGREFEGEEEY---LEILGITREQSGKYECKAANEVSSADVK 209
+G P P +TW + G L++ + Q+G Y C A N + A K
Sbjct: 1957 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-K 2015
Query: 210 QVKVTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
V V P I S + + G++ L CEA P PD W +D + + G +
Sbjct: 2016 DFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL 2075
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL----VLFRPGSVRGINGSISL 320
+ SL + + G YTCVA N G +A L VL P +G +GS +L
Sbjct: 2076 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTL 2132
Score = 88.2 bits (217), Expect = 1e-17
Identities = 67/237 (28%), Positives = 102/237 (43%), Gaps = 36/237 (15%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS-------SDVTVNEG 146
+ L+I D G YTC V + ++ V +PP IS +V
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTGR-EFEGEEEYLEILGITREQSGKYECKAAN 201
S +TL C + P P I W + +TP+ R + GE L+I SG+Y C A N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 202 EVSSADVKQVKVTVNYPPTITE-----------SKSNEATTG----------RQASLKCE 240
V+ D + V + PP + S+ EA G A L C+
Sbjct: 1524 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+A+P PD WYR+D +++ G E+ +G L + V E+ G Y+C A+N++G
Sbjct: 1583 TNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/213 (31%), Positives = 100/213 (46%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
LRI V DEG Y C + + L V PP I SN + +V V E V L+C
Sbjct: 274 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLC 333
Query: 154 MANGRPEPVITW---RHLTPTGRE--FEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
A G P P ITW L PT + + L++ +G Y CKA+N V +A+
Sbjct: 334 EARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE- 392
Query: 209 KQVKVTVNYPPTITESKSN----EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
K ++ V PPTI + +A GR +L+C A P+P W+ + + +N
Sbjct: 393 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 452
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
++ T+G S L + + E G Y+CVA++ G
Sbjct: 453 RLE-TDG-SVLRLESPGEASSGLYSCVASSPAG 483
Score = 86.7 bits (213), Expect = 3e-17
Identities = 62/204 (30%), Positives = 87/204 (42%), Gaps = 24/204 (11%)
Query: 107 GSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWR 166
G YTCS + V+L VQ P + + S V V L C A+G P P ITW+
Sbjct: 2732 GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ 2791
Query: 167 ------------HLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
+ P G+ L I + E +G Y C A N SA + + ++
Sbjct: 2792 KEGLNVATGVSTQVLPGGQ--------LRIAHASPEDAGNYLCIAKNSAGSA-MGKTRLV 2842
Query: 215 VNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
V PP I + +TT G A L C+A P P+ W +D ++ A G G+
Sbjct: 2843 VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE- 2901
Query: 274 SLTVTNVTEEHYGNYTCVAANKLG 297
L V N+ + G YTC A N +G
Sbjct: 2902 -LLVKNLEGQDAGTYTCTAENAVG 2924
Score = 84.7 bits (208), Expect = 1e-16
Identities = 71/240 (29%), Positives = 103/240 (42%), Gaps = 27/240 (11%)
Query: 78 WSLDPRVELEKRHSLEYS-----LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP 132
W D R LE R + S L++ + DV+D G YTC Q L V V P
Sbjct: 913 WWKDGR-PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP 971
Query: 133 KIS-NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITRE- 190
S +TV EG +L C G P P I+WR G+ GE L+ +
Sbjct: 972 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK---DGQPLPGEGAGLQHVSAVGRL 1028
Query: 191 ---------QSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTG----RQASL 237
Q G Y C+ +N V ++ + +++ V+ PP I + A+L
Sbjct: 1029 LYLGQAQLAQEGTYTCECSNVVGNSS-QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 1087
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+C A+ P P W RD + + GL++++ +GQ SL V H G Y+CVA N G
Sbjct: 1088 ECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQ-SLHVERAQAAHTGRYSCVAENLAG 1145
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/274 (27%), Positives = 114/274 (41%), Gaps = 29/274 (10%)
Query: 37 GTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95
G+ + R G+ + C V V+WL + G+ P + H ++
Sbjct: 2128 GSGTLVSRPGELVTMVCPVRGSPPIHVSWL-KDGLPL---------PLSQRTLLHGSGHT 2177
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI--SSDVTVNEGSNVTLVC 153
LRI KV + D G +TC + L VQVPP + + +DV V GS V L C
Sbjct: 2178 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 2237
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK 212
A G P P+++W + P + + L++ + SG Y C A +E A + +
Sbjct: 2238 EARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQ 2296
Query: 213 VTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
+TV PP I +S T G L C+A P P+ W++D G +
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD--------GQALTRL 2348
Query: 270 EGQSSLT-VTNVTEEHYGNYTCVAANKLGVTNAS 302
E S T V V + G YTC+A + G S
Sbjct: 2349 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKS 2380
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/278 (27%), Positives = 119/278 (42%), Gaps = 30/278 (10%)
Query: 40 NITVRQGDTAILRCVVEDKNSK-VAWLNRSGIIFAGHDKWSLDPRVELEKRHSL--EYSL 96
N++V Q TA+L C + + V+W D+ LDPR R + E SL
Sbjct: 2492 NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVPLDPR---SPRFEILPEGSL 2537
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
RIQ V D G Y C L V PP I+ S++T+ + L C A+
Sbjct: 2538 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2597
Query: 157 GRPEPVITWRHLTPTGREFEGEEEYLEILGITR--------EQSGKYECKAANEVSSADV 208
G P+P++ W +F ++ +L + S ++EC +NEV A
Sbjct: 2598 GSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH- 2655
Query: 209 KQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ +VTV+ PPTI + +++ T L C ++ +PAP W + ++ +
Sbjct: 2656 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2715
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S G +L + H G YTC A N GV + + L
Sbjct: 2716 SPSG--ALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751
Score = 82.8 bits (203), Expect = 4e-16
Identities = 73/291 (25%), Positives = 125/291 (42%), Gaps = 26/291 (8%)
Query: 36 RGTDNITVRQGDTAILRCVVEDKN-SKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
R + +TVR+G L C K++W + G G L+ ++
Sbjct: 976 RESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGEG-------AGLQHVSAVGR 1027
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS---SDVTVNEGSNVTL 151
L + + + EG+YTC + + L V VPP+I+ + V+V + TL
Sbjct: 1028 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 1087
Query: 152 VCMANGRPEPVITW-RHLTPTGREF----EGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G+P P +TW R P G E + + + L + +G+Y C A N A
Sbjct: 1088 ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147
Query: 207 DVKQVKVTVNYPPTITES----KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ ++ +++V PP + + A +L CEA +P P W+R + ++
Sbjct: 1148 E-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP-- 1204
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT--NASLVLFRPGSV 311
G + G L +T E+ G Y+C+A+N+ G N S+ + P S+
Sbjct: 1205 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1255
Score = 81.6 bits (200), Expect = 9e-16
Identities = 71/269 (26%), Positives = 103/269 (38%), Gaps = 27/269 (10%)
Query: 39 DNITVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
+ +T + L C V N +V W S + G + + L ++L+
Sbjct: 1754 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT----------HTLQ 1803
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI----SSDVTVNEGSNVTLVC 153
+ + + D G YTC V L V VPP V V G L C
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1863
Query: 154 MANGRPEPVITWRH------LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
+ PEP +TW L + G + LEI G Y CK +N V+
Sbjct: 1864 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSN-VAGEA 1921
Query: 208 VKQVKVTVNYPPTITESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
V+ +TV PPT K+ + G L C+ S VPAP W +D + S+
Sbjct: 1922 VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHG 1981
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAAN 294
+ S G+ L ++ + G YTCVA N
Sbjct: 1982 VVSRGGR--LQLSRLQPAQAGTYTCVAEN 2008
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 14/219 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSD---VTVNEGSNVTLV 152
L++ + D G YTC L V VPP I V G V L
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 426
Query: 153 CMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C+A G P P ++W H E + L + SG Y C A++ A
Sbjct: 427 CVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA- 485
Query: 208 VKQVKVTVNYPPTITESKS-NEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
V Q V V PP + ++ + TT G+ L C+AS P P +W ++ G+
Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 545
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
++ S ++L + +V +H G + C A N+ G A +
Sbjct: 546 QVASQ--GTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582
Score = 79.0 bits (193), Expect = 6e-15
Identities = 67/255 (26%), Positives = 109/255 (42%), Gaps = 18/255 (7%)
Query: 50 ILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGS 108
+L C VE + + K+ W +R GI+ D + +R L++Q + D G
Sbjct: 2409 VLECSVEAEPAPKITW-HRDGIVLQE------DAHTQFPERGRF---LQLQALSTADSGD 2458
Query: 109 YTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH- 167
Y+C+ + + + + P I + V V+ L C A+G P P+++WR
Sbjct: 2459 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Query: 168 ---LTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITE 223
L P FE E L I + + +G Y C A+N S D + + V PP I
Sbjct: 2519 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS-DRQGRDLRVLEPPAIAP 2577
Query: 224 SKSNEATTGR-QASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTE 282
S SN T A L CEAS P P W++D +++ ++L +T
Sbjct: 2578 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP 2637
Query: 283 EHYGNYTCVAANKLG 297
+ + CV +N++G
Sbjct: 2638 QDSAQFECVVSNEVG 2652
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 10/199 (5%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D + C V + + V VPP I++ +D TV + V L C + G P P ++
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698
Query: 165 W----RHLTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W L G + LEI +G+Y C A N A K V +TV P
Sbjct: 2699 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASP 2757
Query: 220 TITESKS-NEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVT 278
+ S A + L CEAS +P P W ++ +N A G+ + G L +
Sbjct: 2758 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPG-GQLRIA 2814
Query: 279 NVTEEHYGNYTCVAANKLG 297
+ + E GNY C+A N G
Sbjct: 2815 HASPEDAGNYLCIAKNSAG 2833
Score = 77.0 bits (188), Expect = 2e-14
Identities = 60/213 (28%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI----SNISSDVTVNEGSNVTL 151
L+I V + G Y+C + L+V PP I + +VTVN S V+L
Sbjct: 1615 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1674
Query: 152 VCMANGRPEPVITWRH----LTPTGR-EFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G P P I+W +P+ R + + + L++ + Y C A N+ SA
Sbjct: 1675 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1734
Query: 207 DVKQVKVTVNYPPTITESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
+ K + V PP I + T SL C+ A P P+ WY+D ++ G
Sbjct: 1735 E-KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL--GE 1791
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
E+ G +L + G YTC A N G
Sbjct: 1792 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1824
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 78 WSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--S 135
W D L + SL+++ V D G+Y+C ++ L V PP I S
Sbjct: 2249 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308
Query: 136 NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKY 195
+++++ G+ + L+C A G P+P ITW E +L + +G Y
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV--RDAGLY 2366
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGR---QASLKCEASAVPAPDFEWY 252
C A + + + K +V V PP I + G Q L+C A PAP W+
Sbjct: 2367 TCLAESPAGAIE-KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWH 2425
Query: 253 RDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
RD I + E L + ++ G+Y+C A N G T+ +
Sbjct: 2426 RDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2473
Score = 75.5 bits (184), Expect = 6e-14
Identities = 70/285 (24%), Positives = 115/285 (40%), Gaps = 23/285 (8%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
++R GD LRC + R G W+++ R E + +Q+
Sbjct: 2948 SLRLGDRLWLRCAARGSPTP-----RIG--------WTVNDRPVTEGVSEQDGGSTLQRA 2994
Query: 102 DVY--DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE-GSNVTLVCMANGR 158
V D G+Y C + + + ++ V+ P + + V G ++ L C+ G
Sbjct: 2995 AVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 3054
Query: 159 PEPVITWRH----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I W L + + + L I R+ +G+Y+C A NE+ A + V
Sbjct: 3055 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 3114
Query: 215 VNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSS 274
+ P E + +G +L+C+A+ P P EW + + ++ L T S
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR---TLPDGS 3171
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSIS 319
L + NV G Y CVA N LG A L G +G GS++
Sbjct: 3172 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3216
Score = 73.6 bits (179), Expect = 2e-13
Identities = 64/217 (29%), Positives = 96/217 (44%), Gaps = 20/217 (9%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTL 151
SL +++ G Y+C + + L V VPP++ + +++T S +TL
Sbjct: 1122 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTL 1181
Query: 152 VCMANGRPEPVITW-RHLTPTGREFEGEEEYL----EILGITREQ---SGKYECKAANEV 203
+C A G P P I W R P GE+ YL +L +T+ Q SG Y C A+NE
Sbjct: 1182 LCEAMGIPPPAIRWFRGEEPVS---PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238
Query: 204 SSADVKQVKVTVNYPPTITESKSNE---ATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
A + V V PP+I E G+ A L C + P P W++D +
Sbjct: 1239 GEAR-RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1297
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I S +G L V G+Y+C+AAN +G
Sbjct: 1298 GDAHHI-SPDG-VLLQVLQANLSSAGHYSCIAANAVG 1332
Score = 72.8 bits (177), Expect = 4e-13
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 10/209 (4%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D G Y+C + V L V +PP I +V+V +V L C ++ P PV++
Sbjct: 853 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 912
Query: 165 W----RHLTP-TGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W R L P G ++ L++ +G Y C+A N+ ++ K + V P
Sbjct: 913 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSE-KHYNLNVWVAP 971
Query: 220 T--ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI-NSANGLEIKSTEGQSSLT 276
+ ES + G SL CE VP P W +D + GL+ S G+ L
Sbjct: 972 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 1030
Query: 277 VTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ G YTC +N +G ++ L L
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059
Score = 69.3 bits (168), Expect = 5e-12
Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 16/223 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
L++ ++ G+YTC + + V V P+I S ++ + V EG V L C
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 2048
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEY------LEILGITREQSGKYECKAANEVSSA 206
A+G+P P + W + +P G++ + L + G+ +G Y C A N
Sbjct: 2049 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGE- 2107
Query: 207 DVKQVKVTVNYPPTITESKSNEATT----GRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
D + V V PPTI + T G ++ C P W +D + +
Sbjct: 2108 DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ 2167
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + +L ++ V G +TCVAA+ GV + + L
Sbjct: 2168 RTLLHGSG--HTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2208
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 16/199 (8%)
Query: 131 PPKI--SNISSDVTVNEGSNVTLVCMANGRPEPVITW----RHLTPTGREFEGEE--EYL 182
PP + + + +V G++V L C +G P P + W + + P G + +E + L
Sbjct: 215 PPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL 274
Query: 183 EILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTI---TESKSNEATTGRQASLKC 239
I G G+Y+C A + + + ++ V+ PPTI E+ L C
Sbjct: 275 RITGSHVGDEGRYQCVAFSP-AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLC 333
Query: 240 EASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
EA VP P+ W++D + ++ ++ T G L + G YTC A+N +G
Sbjct: 334 EARGVPTPNITWFKDGALLPTST--KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA 391
Query: 300 NAS--LVLFRPGSVRGING 316
+ L ++ P ++ G G
Sbjct: 392 EKATRLDVYVPPTIEGAGG 410
Score = 65.5 bits (158), Expect = 7e-11
Identities = 38/112 (33%), Positives = 58/112 (51%), Gaps = 12/112 (10%)
Query: 153 CMANGRPEPVITWRHLTPTGREFEG-------EEEYLEILGITREQSGKYECKAANEVSS 205
C +G P+P +TWR P+ G EE L + ++ SG YEC+A NEV S
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 206 ADVKQVKVTVNYPPTITES--KSN-EATTGRQASLKCEASAVPAPDFEWYRD 254
++ K+ V PP+I E K+N G+ +L+C+A+ P P+ W +D
Sbjct: 83 TS-RRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133
Score = 55.8 bits (133), Expect = 5e-08
Identities = 63/269 (23%), Positives = 98/269 (36%), Gaps = 40/269 (14%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVT 150
E SL + V D G Y C + + + L+V VPP I ++V+ G ++T
Sbjct: 56 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 115
Query: 151 LVCMANGRPEPVITWRHLTPT--------------------GREFEGEEEYLEILGITRE 190
L C ANG P P I W G E + L I
Sbjct: 116 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPG 175
Query: 191 QSGKYECKAANEVSS--------ADVKQVKVTVNY----PPTITESKSNE---ATTGRQA 235
+SG+ +A + A +Q + PP++ + + + G
Sbjct: 176 RSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADV 235
Query: 236 SLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANK 295
L+C S VP P EW +D + G ++ E L +T G Y CVA +
Sbjct: 236 ELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 294
Query: 296 LG--VTNASLVLFRPGSVRGINGSISLAV 322
G + L + P ++ G N + +AV
Sbjct: 295 AGQQARDFQLRVHAPPTIWGSNETGEVAV 323
Score = 34.3 bits (77), Expect = 0.16
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 230 TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYT 289
T G +A C P P W R +G + + SL + +V+ G+Y
Sbjct: 16 TVGLEAG-GCGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYE 73
Query: 290 CVAANKLGVTN--ASLVLFRPGSVR 312
C A N++G T+ A LV++ P S+R
Sbjct: 74 CQATNEVGSTSRRAKLVVYVPPSIR 98
Score = 33.1 bits (74), Expect = 0.36
Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 16/120 (13%)
Query: 15 VLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFA 73
V +++ L+ PV V+ ++TVR GD LRC + + WL +
Sbjct: 3105 VAKKVVILVLQSAPVFQVE----PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL-- 3158
Query: 74 GHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK 133
R R + SL ++ V+ D G+Y C T++ +L+V+ P+
Sbjct: 3159 ---------RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 100 bits (248), Expect = 2e-21
Identities = 71/249 (28%), Positives = 111/249 (44%), Gaps = 28/249 (11%)
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
+SL L+I+KVD+ DEG YTC+ +V L V VPP I + V E ++V
Sbjct: 562 YSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASV 621
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGIT--------------REQSGKY 195
TL C+A+G P P ++W F+G + +G+T +G Y
Sbjct: 622 TLECLASGVPPPDVSW---------FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 672
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTIT--ESKSNEATTGRQASLKCEASAVPAPDFEWYR 253
C A+N S +++ + VN PP IT S L C A+ P+P W +
Sbjct: 673 RCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK 731
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL--FRPGSV 311
D ++ A ++ G LT+ + G Y+CVA + +G +VL P S+
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 791
Query: 312 RGINGSISL 320
G ++S+
Sbjct: 792 LGEELNVSV 800
Score = 92.0 bits (227), Expect = 7e-19
Identities = 65/240 (27%), Positives = 101/240 (42%), Gaps = 32/240 (13%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--ISSDVTVNEGSNVTL 151
+ L++ + D G Y+C + + V VPP I N + + V +G L
Sbjct: 1124 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 1183
Query: 152 VCMANGRPEPVITW------------RHLTPTGREFEGEEEYLEILGITREQSGKYECKA 199
+C G P+P +TW H++P G L++L +G Y C A
Sbjct: 1184 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG-------VLLQVLQANLSSAGHYSCIA 1236
Query: 200 ANEVSSADVKQVKVTVNYPPTITESKSNEA------TTGRQASLKCEASAVPAPDFEWYR 253
AN V K +++V PTI + A T SL CEA A P+P+ W +
Sbjct: 1237 ANAVGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGSV 311
D ++ +++ G L + N +E G YTCV N+LG V N + + P S+
Sbjct: 1296 DGAPFEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSI 1353
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/215 (30%), Positives = 93/215 (43%), Gaps = 17/215 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
LRI D G+Y C + + L+VQVPP I N D++ EGS+ L C A
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779
Query: 156 NGRPEPVITWRHLTPTGREFEGEE--------EYLEILGITREQSGKYECKAANEVSSAD 207
G PEP ITW G+ G E L + + + +G Y C A N V A
Sbjct: 2780 RGSPEPNITW---DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRAR 2836
Query: 208 VKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
++V +T+ P T + + G + L+C A P P W +D + +
Sbjct: 2837 -RRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----V 2891
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNA 301
+G S+L V+ E G Y C A N++G T A
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 2926
Score = 90.9 bits (224), Expect = 1e-18
Identities = 84/298 (28%), Positives = 122/298 (40%), Gaps = 30/298 (10%)
Query: 39 DNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLE--YSL 96
D + VR GD A+L C + + G P V ++ +L L
Sbjct: 1758 DAVLVRVGDKAVLSCETDALPEPTVTWYKDG-----------QPLVLAQRTQALRGGQRL 1806
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE--GSNVTLVCM 154
IQ+ V D+G Y+C V L VQVPP N ++ TV++ GS + L C
Sbjct: 1807 EIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE-TVSQVAGSPLVLTCD 1865
Query: 155 ANGRPEPVITWR--HLTPTGREFEGEEEY---LEILGITREQSGKYECKAANEVSSADVK 209
+G P P +TW + G L++ + Q+G Y C A N + A K
Sbjct: 1866 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-K 1924
Query: 210 QVKVTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
V V P I S + + G++ L CEA P PD W +D + + G +
Sbjct: 1925 DFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL 1984
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL----VLFRPGSVRGINGSISL 320
+ SL + + G YTCVA N G +A L VL P +G +GS +L
Sbjct: 1985 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTL 2041
Score = 88.2 bits (217), Expect = 1e-17
Identities = 67/237 (28%), Positives = 102/237 (43%), Gaps = 36/237 (15%)
Query: 94 YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS-------SDVTVNEG 146
+ L+I D G YTC V + ++ V +PP IS +V
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTGR-EFEGEEEYLEILGITREQSGKYECKAAN 201
S +TL C + P P I W + +TP+ R + GE L+I SG+Y C A N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 202 EVSSADVKQVKVTVNYPPTITE-----------SKSNEATTG----------RQASLKCE 240
V+ D + V + PP + S+ EA G A L C+
Sbjct: 1433 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+A+P PD WYR+D +++ G E+ +G L + V E+ G Y+C A+N++G
Sbjct: 1492 TNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/213 (31%), Positives = 100/213 (46%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
LRI V DEG Y C + + L V PP I SN + +V V E V L+C
Sbjct: 183 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLC 242
Query: 154 MANGRPEPVITW---RHLTPTGRE--FEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
A G P P ITW L PT + + L++ +G Y CKA+N V +A+
Sbjct: 243 EARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE- 301
Query: 209 KQVKVTVNYPPTITESKSN----EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
K ++ V PPTI + +A GR +L+C A P+P W+ + + +N
Sbjct: 302 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 361
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
++ T+G S L + + E G Y+CVA++ G
Sbjct: 362 RLE-TDG-SVLRLESPGEASSGLYSCVASSPAG 392
Score = 86.7 bits (213), Expect = 3e-17
Identities = 62/204 (30%), Positives = 87/204 (42%), Gaps = 24/204 (11%)
Query: 107 GSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWR 166
G YTCS + V+L VQ P + + S V V L C A+G P P ITW+
Sbjct: 2641 GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ 2700
Query: 167 ------------HLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
+ P G+ L I + E +G Y C A N SA + + ++
Sbjct: 2701 KEGLNVATGVSTQVLPGGQ--------LRIAHASPEDAGNYLCIAKNSAGSA-MGKTRLV 2751
Query: 215 VNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
V PP I + +TT G A L C+A P P+ W +D ++ A G G+
Sbjct: 2752 VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE- 2810
Query: 274 SLTVTNVTEEHYGNYTCVAANKLG 297
L V N+ + G YTC A N +G
Sbjct: 2811 -LLVKNLEGQDAGTYTCTAENAVG 2833
Score = 84.0 bits (206), Expect = 2e-16
Identities = 59/235 (25%), Positives = 103/235 (43%), Gaps = 16/235 (6%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLV 152
SL ++ D G Y+C + Q +L+V PP + + + +V G++V L
Sbjct: 88 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQ 147
Query: 153 CMANGRPEPVITW----RHLTPTGREFEGEE--EYLEILGITREQSGKYECKAANEVSSA 206
C +G P P + W + + P G + +E + L I G G+Y+C A + +
Sbjct: 148 CWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP-AGQ 206
Query: 207 DVKQVKVTVNYPPTI---TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
+ ++ V+ PPTI E+ L CEA VP P+ W++D + ++
Sbjct: 207 QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST- 265
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS--LVLFRPGSVRGING 316
++ T G L + G YTC A+N +G + L ++ P ++ G G
Sbjct: 266 -KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319
Score = 84.0 bits (206), Expect = 2e-16
Identities = 71/240 (29%), Positives = 102/240 (42%), Gaps = 27/240 (11%)
Query: 78 WSLDPRVELEKRHSLEYS-----LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP 132
W D R LE R + S L++ + DV+D G YTC Q L V V P
Sbjct: 822 WWKDGR-PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 880
Query: 133 KIS-NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITRE- 190
S +TV EG L C G P P I+WR G+ GE L+ +
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRK---DGQPLPGEGAGLQHVSAVGRL 937
Query: 191 ---------QSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTG----RQASL 237
Q G Y C+ +N V ++ + +++ V+ PP I + A+L
Sbjct: 938 LYLGQAQLAQEGTYTCECSNVVGNSS-QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 996
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+C A+ P P W RD + + GL++++ +GQ SL V H G Y+CVA N G
Sbjct: 997 ECNATGKPPPTVTWERDGQPVGAELGLQLQN-QGQ-SLHVERAQAAHTGRYSCVAENLAG 1054
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/274 (27%), Positives = 114/274 (41%), Gaps = 29/274 (10%)
Query: 37 GTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95
G+ + R G+ + C V V+WL + G+ P + H ++
Sbjct: 2037 GSGTLVSRPGELVTMVCPVRGSPPIHVSWL-KDGLPL---------PLSQRTLLHGSGHT 2086
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI--SSDVTVNEGSNVTLVC 153
LRI KV + D G +TC + L VQVPP + + +DV V GS V L C
Sbjct: 2087 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPC 2146
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK 212
A G P P+++W + P + + L++ + SG Y C A +E A + +
Sbjct: 2147 EARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQ 2205
Query: 213 VTVNYPPTITES---KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
+TV PP I +S T G L C+A P P+ W++D G +
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD--------GQALTRL 2257
Query: 270 EGQSSLT-VTNVTEEHYGNYTCVAANKLGVTNAS 302
E S T V V + G YTC+A + G S
Sbjct: 2258 ENNSRATRVLRVRDA--GLYTCLAESPAGAIEKS 2289
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/278 (27%), Positives = 119/278 (42%), Gaps = 30/278 (10%)
Query: 40 NITVRQGDTAILRCVVEDKNSK-VAWLNRSGIIFAGHDKWSLDPRVELEKRHSL--EYSL 96
N++V Q TA+L C + + V+W D+ LDPR R + E SL
Sbjct: 2401 NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVPLDPR---SPRFEILPEGSL 2446
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
RIQ V D G Y C L V PP I+ S++T+ + L C A+
Sbjct: 2447 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2506
Query: 157 GRPEPVITWRHLTPTGREFEGEEEYLEILGITR--------EQSGKYECKAANEVSSADV 208
G P+P++ W +F ++ +L + S ++EC +NEV A
Sbjct: 2507 GSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH- 2564
Query: 209 KQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ +VTV+ PPTI + +++ T L C ++ +PAP W + ++ +
Sbjct: 2565 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2624
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S G +L + H G YTC A N GV + + L
Sbjct: 2625 SPSG--ALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660
Score = 82.4 bits (202), Expect = 5e-16
Identities = 73/291 (25%), Positives = 125/291 (42%), Gaps = 26/291 (8%)
Query: 36 RGTDNITVRQGDTAILRCVVEDKN-SKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
R + +TVR+G L C K++W + G G L+ ++
Sbjct: 885 RESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGEG-------AGLQHVSAVGR 936
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS---SDVTVNEGSNVTL 151
L + + + EG+YTC + + L V VPP+I+ + V+V + TL
Sbjct: 937 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 996
Query: 152 VCMANGRPEPVITW-RHLTPTGREF----EGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G+P P +TW R P G E + + + L + +G+Y C A N A
Sbjct: 997 ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056
Query: 207 DVKQVKVTVNYPPTITES----KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ ++ +++V PP + + A +L CEA +P P W+R + ++
Sbjct: 1057 E-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP-- 1113
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT--NASLVLFRPGSV 311
G + G L +T E+ G Y+C+A+N+ G N S+ + P S+
Sbjct: 1114 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1164
Score = 81.6 bits (200), Expect = 9e-16
Identities = 71/269 (26%), Positives = 103/269 (38%), Gaps = 27/269 (10%)
Query: 39 DNITVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
+ +T + L C V N +V W S + G + + L ++L+
Sbjct: 1663 EQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT----------HTLQ 1712
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI----SSDVTVNEGSNVTLVC 153
+ + + D G YTC V L V VPP V V G L C
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC 1772
Query: 154 MANGRPEPVITWRH------LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
+ PEP +TW L + G + LEI G Y CK +N V+
Sbjct: 1773 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSN-VAGEA 1830
Query: 208 VKQVKVTVNYPPTITESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
V+ +TV PPT K+ + G L C+ S VPAP W +D + S+
Sbjct: 1831 VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHG 1890
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAAN 294
+ S G+ L ++ + G YTCVA N
Sbjct: 1891 VVSRGGR--LQLSRLQPAQAGTYTCVAEN 1917
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/219 (26%), Positives = 88/219 (40%), Gaps = 14/219 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSD---VTVNEGSNVTLV 152
L++ + D G YTC L V VPP I V G V L
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 335
Query: 153 CMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C+A G P P ++W H E + L + SG Y C A++ A
Sbjct: 336 CVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA- 394
Query: 208 VKQVKVTVNYPPTITESKS-NEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
V Q V V PP + ++ + TT G+ L C+AS P P +W ++ G+
Sbjct: 395 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 454
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
++ S ++L + +V +H G + C A N+ G A +
Sbjct: 455 QVASQ--GTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491
Score = 79.0 bits (193), Expect = 6e-15
Identities = 67/255 (26%), Positives = 109/255 (42%), Gaps = 18/255 (7%)
Query: 50 ILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGS 108
+L C VE + + K+ W +R GI+ D + +R L++Q + D G
Sbjct: 2318 VLECSVEAEPAPKITW-HRDGIVLQE------DAHTQFPERGRF---LQLQALSTADSGD 2367
Query: 109 YTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH- 167
Y+C+ + + + + P I + V V+ L C A+G P P+++WR
Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Query: 168 ---LTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITE 223
L P FE E L I + + +G Y C A+N S D + + V PP I
Sbjct: 2428 RVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS-DRQGRDLRVLEPPAIAP 2486
Query: 224 SKSNEATTGR-QASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTE 282
S SN T A L CEAS P P W++D +++ ++L +T
Sbjct: 2487 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP 2546
Query: 283 EHYGNYTCVAANKLG 297
+ + CV +N++G
Sbjct: 2547 QDSAQFECVVSNEVG 2561
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 10/199 (5%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D + C V + + V VPP I++ +D TV + V L C + G P P ++
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607
Query: 165 W----RHLTPTGREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W L G + LEI +G+Y C A N A K V +TV P
Sbjct: 2608 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASP 2666
Query: 220 TITESKS-NEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVT 278
+ S A + L CEAS +P P W ++ +N A G+ + G L +
Sbjct: 2667 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPG-GQLRIA 2723
Query: 279 NVTEEHYGNYTCVAANKLG 297
+ + E GNY C+A N G
Sbjct: 2724 HASPEDAGNYLCIAKNSAG 2742
Score = 77.0 bits (188), Expect = 2e-14
Identities = 60/213 (28%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI----SNISSDVTVNEGSNVTL 151
L+I V + G Y+C + L+V PP I + +VTVN S V+L
Sbjct: 1524 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1583
Query: 152 VCMANGRPEPVITWRH----LTPTGR-EFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
C A G P P I+W +P+ R + + + L++ + Y C A N+ SA
Sbjct: 1584 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1643
Query: 207 DVKQVKVTVNYPPTITESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
+ K + V PP I + T SL C+ A P P+ WY+D ++ G
Sbjct: 1644 E-KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL--GE 1700
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
E+ G +L + G YTC A N G
Sbjct: 1701 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1733
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 78 WSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--S 135
W D L + SL+++ V D G+Y+C ++ L V PP I S
Sbjct: 2158 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217
Query: 136 NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKY 195
+++++ G+ + L+C A G P+P ITW E +L + +G Y
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV--RDAGLY 2275
Query: 196 ECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGR---QASLKCEASAVPAPDFEWY 252
C A + + + K +V V PP I + G Q L+C A PAP W+
Sbjct: 2276 TCLAESPAGAIE-KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWH 2334
Query: 253 RDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
RD I + E L + ++ G+Y+C A N G T+ +
Sbjct: 2335 RDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2382
Score = 75.9 bits (185), Expect = 5e-14
Identities = 70/285 (24%), Positives = 115/285 (40%), Gaps = 23/285 (8%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
++R GD LRC + R G W+++ R E + +Q+
Sbjct: 2857 SLRLGDRLWLRCAARGSPTP-----RIG--------WTVNDRPVTEGVSEQDGGSTLQRA 2903
Query: 102 DVY--DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE-GSNVTLVCMANGR 158
V D G+Y C + + + ++ V+ P + + V G ++ L C+ G
Sbjct: 2904 AVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 2963
Query: 159 PEPVITWRH----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
P P I W L + + + L I R+ +G+Y+C A NE+ A + V
Sbjct: 2964 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVL 3023
Query: 215 VNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSS 274
+ P E + +G +L+C+A+ P P EW + + ++ L T S
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR---TLPDGS 3080
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSIS 319
L + NV G Y CVA N LG A L G +G GS++
Sbjct: 3081 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3125
Score = 73.6 bits (179), Expect = 2e-13
Identities = 64/217 (29%), Positives = 96/217 (44%), Gaps = 20/217 (9%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTL 151
SL +++ G Y+C + + L V VPP++ + +++T S +TL
Sbjct: 1031 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTL 1090
Query: 152 VCMANGRPEPVITW-RHLTPTGREFEGEEEYL----EILGITREQ---SGKYECKAANEV 203
+C A G P P I W R P GE+ YL +L +T+ Q SG Y C A+NE
Sbjct: 1091 LCEAMGIPPPAIRWFRGEEPVS---PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147
Query: 204 SSADVKQVKVTVNYPPTITESKSNE---ATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
A + V V PP+I E G+ A L C + P P W++D +
Sbjct: 1148 GEAR-RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1206
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ I S +G L V G+Y+C+AAN +G
Sbjct: 1207 GDAHHI-SPDG-VLLQVLQANLSSAGHYSCIAANAVG 1241
Score = 70.9 bits (172), Expect = 2e-12
Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 10/209 (4%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D G Y+C + V L V +PP I +V+V +V L C ++ P PV++
Sbjct: 762 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821
Query: 165 W----RHLTP-TGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
W R L P G ++ L++ +G Y C+A N+ ++ K + V P
Sbjct: 822 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSE-KHYNLNVWVAP 880
Query: 220 T--ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI-NSANGLEIKSTEGQSSLT 276
+ ES + G L CE VP P W +D + GL+ S G+ L
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 939
Query: 277 VTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ G YTC +N +G ++ L L
Sbjct: 940 LGQAQLAQEGTYTCECSNVVGNSSQDLQL 968
Score = 69.3 bits (168), Expect = 5e-12
Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 16/223 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKI--SNISSDVTVNEGSNVTLVC 153
L++ ++ G+YTC + + V V P+I S ++ + V EG V L C
Sbjct: 1898 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 1957
Query: 154 MANGRPEPVITW-RHLTPTGREFEGEEEY------LEILGITREQSGKYECKAANEVSSA 206
A+G+P P + W + +P G++ + L + G+ +G Y C A N
Sbjct: 1958 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGE- 2016
Query: 207 DVKQVKVTVNYPPTITESKSNEATT----GRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
D + V V PPTI + T G ++ C P W +D + +
Sbjct: 2017 DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ 2076
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + +L ++ V G +TCVAA+ GV + + L
Sbjct: 2077 RTLLHGSG--HTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2117
Score = 59.3 bits (142), Expect = 5e-09
Identities = 56/220 (25%), Positives = 83/220 (37%), Gaps = 29/220 (13%)
Query: 130 VPPKISNISSDVTVN--EGSNVTLVCMANGRPEPVITWRHLTPT---------------- 171
VPP I V+ G ++TL C ANG P P I W
Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 172 ----GREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSN 227
G E + L I SG Y C+A N+ +A + + V PP++ + +
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQ-RDFHLLVLTPPSVLGAGAA 133
Query: 228 EAT---TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEH 284
+ G L+C S VP P EW +D + G ++ E L +T
Sbjct: 134 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGD 192
Query: 285 YGNYTCVAANKLG--VTNASLVLFRPGSVRGINGSISLAV 322
G Y CVA + G + L + P ++ G N + +AV
Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAV 232
Score = 33.1 bits (74), Expect = 0.36
Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 16/120 (13%)
Query: 15 VLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFA 73
V +++ L+ PV V+ ++TVR GD LRC + + WL +
Sbjct: 3014 VAKKVVILVLQSAPVFQVE----PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL-- 3067
Query: 74 GHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK 133
R R + SL ++ V+ D G+Y C T++ +L+V+ P+
Sbjct: 3068 ---------RASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 99.8 bits (247), Expect = 3e-21
Identities = 70/230 (30%), Positives = 102/230 (44%), Gaps = 23/230 (10%)
Query: 95 SLRIQKVDVYDEGSYTCS--VQTQHEPKTSQVYLIVQVPPKIS--NISSDVTVNEGSNVT 150
+L+I ++ DEG Y C V+ + E + +IV VPP IS S + T G +T
Sbjct: 170 NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMT 229
Query: 151 LVCMANGRPEPVITWRHLTPTGREFEGEEEY--------LEILGITREQSGKYECKAANE 202
C A+G PEP I+W G+ E E+Y L + I G Y C+A N+
Sbjct: 230 FSCRASGSPEPAISWFR---NGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNK 286
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ D KQ + V P I + K+ Q +L C+A P P+ W R
Sbjct: 287 -AGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTE 345
Query: 263 G-------LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
G +E+K G SSL + +V G Y C AA+++G S+ L
Sbjct: 346 GDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
Score = 87.0 bits (214), Expect = 2e-17
Identities = 67/264 (25%), Positives = 110/264 (41%), Gaps = 22/264 (8%)
Query: 46 GDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYD 105
G++ C + + W N G +K RV ++K + L I ++ D
Sbjct: 35 GESKFFTCTAIGEPESIDWYNPQG------EKIISTQRVVVQKE-GVRSRLTIYNANIED 87
Query: 106 EGSYTCSVQTQHEPKTSQVYLIVQVPPKIS--NISSDVTVNEGSNVTLVCMANGRPEPVI 163
G Y C T + +T + +++++ K++ + S +G + +VC + P P +
Sbjct: 88 AGIYRCQA-TDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAV 146
Query: 164 TWRH-----LTPTGREFEG-EEEYLEILGITREQSGKYECKAANEV-SSADVKQVKVTVN 216
+W + T + F L+IL I + G Y C+ E D + + V VN
Sbjct: 147 SWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206
Query: 217 YPPTIT-ESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
PP I+ KS AT G + + C AS P P W+R+ I +K + +
Sbjct: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS--NT 264
Query: 274 SLTVTNVTEEHYGNYTCVAANKLG 297
LTV N+ G Y C A NK G
Sbjct: 265 ELTVRNIINSDGGPYVCRATNKAG 288
Score = 85.5 bits (210), Expect = 6e-17
Identities = 68/284 (23%), Positives = 116/284 (40%), Gaps = 30/284 (10%)
Query: 40 NITVRQGDTAILRCVVEDK-NSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
N T +G+ C ++W R+G + ++K+ L K + E L +
Sbjct: 219 NATAERGEEMTFSCRASGSPEPAISWF-RNGKLIEENEKYIL-------KGSNTE--LTV 268
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
+ + D G Y C + Q +L V V P I + ++ T G VTLVC A G
Sbjct: 269 RNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGE 327
Query: 159 PEPVITWRH------LTPTGREFEGEEEY--------LEILGITREQSGKYECKAANEVS 204
P P ITW+ T + +G E L I + SG+Y+C+AA+ +
Sbjct: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 387
Query: 205 SADVKQVKVTVNYPPTITESKS-NEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
K + + + Y P +++ + G ++ C+ + P W RD + + N
Sbjct: 388 GHQ-KSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNT 446
Query: 264 LEIK--STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+K ST + L + ++ +G Y C A N +G +L
Sbjct: 447 TNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
Score = 55.1 bits (131), Expect = 9e-08
Identities = 46/190 (24%), Positives = 75/190 (39%), Gaps = 13/190 (6%)
Query: 40 NITVRQGDTAILRCVVEDKN-SKVAWLNR-SGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
N T + L C E + ++ W G F DK SLD R+E++ +H SL
Sbjct: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDK-SLDGRIEVKGQHGSS-SLH 366
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANG 157
I+ V + D G Y C ++ +YL ++ PK + + EG+ + + C
Sbjct: 367 IKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKS 426
Query: 158 RPEPVITWR---------HLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
P I WR + T G + LEI + G+Y C A N + +
Sbjct: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQ 486
Query: 209 KQVKVTVNYP 218
+ + + P
Sbjct: 487 EYILALADVP 496
Score = 31.2 bits (69), Expect = 1.4
Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 220 TITESKSNEATTGRQASLKCEASAVPAPDFEWYRDD-TRINSANGLEIKSTEGQSSLTVT 278
TI+ SK E + G C A P +WY +I S + ++ +S LT+
Sbjct: 24 TISLSKV-ELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIY 81
Query: 279 NVTEEHYGNYTCVAANKLGVTNASLVL 305
N E G Y C A + G T + V+
Sbjct: 82 NANIEDAGIYRCQATDAKGQTQEATVV 108
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 97.1 bits (240), Expect = 2e-20
Identities = 70/232 (30%), Positives = 95/232 (40%), Gaps = 13/232 (5%)
Query: 80 LDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISS 139
+DPRV + L IQ V D G Y CS + + ++IVQ P+ +
Sbjct: 385 VDPRVNITPSGGLY----IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440
Query: 140 DVTVNEGSNVTLVCMANGRPEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKY 195
D V EG V C A G P PVI W L+ R L I G+ G+Y
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQY 500
Query: 196 ECKAANEVSSAD-VKQVKVTVNYPPTITESKSNEAT-TGRQASLKCEASAVPAPDFEWYR 253
EC+A N + S V + V P S+ G L C + P P W +
Sbjct: 501 ECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK 560
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
D ++ + I S EG LT+ +V G Y CVA N +G + S+VL
Sbjct: 561 DGVQVTESGKFHI-SPEG--FLTINDVGPADAGRYECVARNTIGSASVSMVL 609
Score = 66.6 bits (161), Expect = 3e-11
Identities = 49/184 (26%), Positives = 79/184 (42%), Gaps = 18/184 (9%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITW-RHLTPTGREFEG-----EEEYLEIL 185
P+I++ D V G+ V C A G P+P I W R+ + + ++ L I
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVNY------PPTITESKSNEATTGRQASLKC 239
G Y+C A N + +VK +VT+ Y P + + ++ E G +L+C
Sbjct: 306 NTQETDQGIYQCMAKN--VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 240 EASAVPAPDFEWYRDD-TRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
A+ P P W R D T + + I + G L + NV + G Y C A N +
Sbjct: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGG---LYIQNVVQGDSGEYACSATNNIDS 420
Query: 299 TNAS 302
+A+
Sbjct: 421 VHAT 424
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/104 (22%), Positives = 40/104 (38%), Gaps = 1/104 (0%)
Query: 204 SSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
S A + ++ P +E + + T+G C A P P+ W R++ ++
Sbjct: 232 SVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD 291
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFR 307
+ + +L + N E G Y C+A N G V R
Sbjct: 292 SRLNLLD-DGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLR 334
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 94.4 bits (233), Expect = 1e-19
Identities = 67/242 (27%), Positives = 104/242 (42%), Gaps = 23/242 (9%)
Query: 78 WSLDPRVELE-KRHSLEYS-LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS 135
W+ D +EL+ RH S L +Q + D G +TC H + +IVQ PP+ +
Sbjct: 363 WTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFT 422
Query: 136 NISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY-------LEILGIT 188
D V E V +C A+G P PVI W T TG + E ++ L I
Sbjct: 423 VTPKDQVVLEEHAVEWLCEADGNPPPVIVW---TKTGGQLPVEGQHTVLSSGTLRIDRAA 479
Query: 189 REQSGKYECKAANEVSSADVKQVKVTVNYPPTITE-----SKSNEATTGRQASLKCEASA 243
+ G+YEC+A VSS VK+V V + P + G+ ++ C A
Sbjct: 480 QHDQGQYECQA---VSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQG 536
Query: 244 VPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
P P W ++ +I + + + + +LT+ + G Y CVA N G+ ++
Sbjct: 537 EPQPIITWNKEGVQITESGKFHV---DDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNM 593
Query: 304 VL 305
L
Sbjct: 594 FL 595
Score = 72.8 bits (177), Expect = 4e-13
Identities = 51/184 (27%), Positives = 75/184 (40%), Gaps = 20/184 (10%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH------LTPTGREFEGEEEYLEIL 185
P+I+ DV V G+ V C A G P+P I W H L R ++ L I
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVN----YPPTITESKSNEATTGRQASLKCEA 241
G Y+C A N A + + + P + + + E G +L+C A
Sbjct: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
Query: 242 SAVPAPDFEWYRDDTRINSANGLEI---KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
+ P P W RD NGLE+ + S L + N+T+ +G +TC A N G
Sbjct: 354 TGHPHPLITWTRD-------NGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGT 406
Query: 299 TNAS 302
A+
Sbjct: 407 VQAA 410
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 93.2 bits (230), Expect = 3e-19
Identities = 79/282 (28%), Positives = 123/282 (43%), Gaps = 29/282 (10%)
Query: 41 ITVRQGDTAILRCVV------EDKNSKVAWLNRSGI-----IFAGHDKWSLDPRVELEKR 89
+T R G++ +LRC V + V W + G+ I G+ +DP E R
Sbjct: 33 VTARAGESVVLRCDVIHPVTGQPPPYVVEWF-KFGVPIPIFIKFGYYPPHVDP--EYAGR 89
Query: 90 HSL--EYSLRIQKVDVYDEGSYTCSV-----QTQHEPKTSQVYLIVQVPPKISNISSD-V 141
SL + SLR+++V D+G Y C V Q S V+L + PP + +
Sbjct: 90 ASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYI 149
Query: 142 TVNEGSNVTLVCMANGRPEPVITWRH---LTPTGREFEGEEEYLEILGITREQSGKYECK 198
EG ++T+ C A G P+P++TW L +++ + L + ++RE G Y C+
Sbjct: 150 EAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCR 209
Query: 199 AANEVSSADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAP-DFEWYRDDT 256
A + + V + V PP I N + A L C A A P + WY D
Sbjct: 210 AYS-IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDE 268
Query: 257 RINSANGLEIK-STEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ N L+++ +L + V E G YTCV +N LG
Sbjct: 269 NVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLG 310
Score = 73.2 bits (178), Expect = 3e-13
Identities = 62/273 (22%), Positives = 99/273 (36%), Gaps = 23/273 (8%)
Query: 41 ITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQK 100
I ++G + + C + + G + K+ + + SL +
Sbjct: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVS-----------DGSLTVTS 197
Query: 101 VDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPE 160
V D G+YTC + +L+VQ PP I + ++TVN + L C A P
Sbjct: 198 VSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPG 257
Query: 161 PVITWRHLTPTGREFEGE---------EEYLEILGITREQSGKYECKAANEVSSADVKQV 211
+ + F+ + + L I + E SGKY C +N + +
Sbjct: 258 NLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASA 317
Query: 212 KVTVNYPPTITESKS-NEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSANGLEIKST 269
+TV YP + G ++C A PA +W +D + L
Sbjct: 318 YLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLM 377
Query: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
E S+ + TEE G YTCV N LG S
Sbjct: 378 E-DGSIRIEEATEEALGTYTCVPYNTLGTMGQS 409
Score = 62.4 bits (150), Expect = 6e-10
Identities = 73/303 (24%), Positives = 117/303 (38%), Gaps = 33/303 (10%)
Query: 39 DNITVRQGDTAILRCVVE--DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSL 96
+NITV A+L C E N W + ++ +D ++L R ++ +L
Sbjct: 236 ENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND-------LKLRVRILIDGTL 288
Query: 97 RIQKVDVYDEGSYTC--SVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
I +V D G YTC S P S YL VQ P ++ N+ + V G + + C
Sbjct: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSAS-AYLTVQYPARVLNMPPVIYVPVGIHGYIRCP 347
Query: 155 ANGRPEP-VITWRHLTPTGREFEGEEEY---------LEILGITREQSGKYECKAANEVS 204
+ P V+ W GR + E+ + I T E G Y C N +
Sbjct: 348 VDAEPPATVVKWNK---DGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLG 404
Query: 205 S-ADVKQVKVTVNYPP--TITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
+ ++ + PP T+ GR+ + C A+ P P W + S
Sbjct: 405 TMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSK 464
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSISLA 321
+ S SL +++E +G + CVA N + AS L G+ GS+ +
Sbjct: 465 H-----SALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ 519
Query: 322 VPL 324
V +
Sbjct: 520 VSM 522
Score = 50.8 bits (120), Expect = 2e-06
Identities = 56/242 (23%), Positives = 100/242 (41%), Gaps = 15/242 (6%)
Query: 77 KWSLDPR-VELEKRHSL----EYSLRIQKVDVYDEGSYTC----SVQTQHEPKTSQVYLI 127
KW+ D R +++EK + S+RI++ G+YTC ++ T + ++ L+
Sbjct: 358 KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPAR--LV 415
Query: 128 VQVPPKISNISS-DVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEG--EEEYLEI 184
++ PP + + + G + + C A G P PVITWR + R L+
Sbjct: 416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQF 475
Query: 185 LGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASA 243
+++E G++EC A N V+S + P S + + T S +
Sbjct: 476 RALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDG 535
Query: 244 VPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
F + + + L + G S L V + E ++ +A NKLG + S
Sbjct: 536 GYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSE 595
Query: 304 VL 305
V+
Sbjct: 596 VV 597
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 88.6 bits (218), Expect = 7e-18
Identities = 62/216 (28%), Positives = 89/216 (41%), Gaps = 10/216 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK-ISNISSDVTVNEGSNVTLVCM 154
LRI KV D G YTC L V+ PPK + + + +G ++ L C
Sbjct: 6328 LRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECK 6387
Query: 155 ANGRPEPVITWRHLTPTGRE-------FEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
+G PE ++W E F L I + E SG Y C+A N V A
Sbjct: 6388 ISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDAS 6447
Query: 208 VKQVKVTVNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
+TV PP T+ S A G L+CE S P + W +D ++ ++ +I
Sbjct: 6448 CSTA-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKI 6506
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
S +SL + N+ G Y C A N++G S
Sbjct: 6507 TSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCS 6542
Score = 87.8 bits (216), Expect = 1e-17
Identities = 59/221 (26%), Positives = 98/221 (44%), Gaps = 10/221 (4%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
+L+I+ VD G YTC + + + +L+VQ P +I + V V E +TL C+
Sbjct: 5104 TLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECV 5163
Query: 155 ANGRPEPVITW----RHLTPT---GREFEGEEEYLEILGITREQSGKYECKAANEV--SS 205
G PE + W + + P+ FE I + ++ SG+Y K N+ SS
Sbjct: 5164 VAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSS 5223
Query: 206 ADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
D + N PP+ T+ + + G ++C+ S +W++D I+++
Sbjct: 5224 CDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKY 5283
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ E SL V N+ E NYTC +N G S +L
Sbjct: 5284 RLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGIL 5324
Score = 86.7 bits (213), Expect = 3e-17
Identities = 58/216 (26%), Positives = 92/216 (42%), Gaps = 20/216 (9%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK-ISNISSDVTVNEGSNVTLVCM 154
L + VD G YTC V + L+V PPK + + + V G + L C
Sbjct: 5387 LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECK 5446
Query: 155 ANGRPEPVITW---RHLTPTGREFE----GEEEYLEILGITREQSGKYECKAANEVSSAD 207
G PE + W H P ++ +++ ++ E SG + C+A N S
Sbjct: 5447 IAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTS 5506
Query: 208 ------VKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
VK+ V ++PP + K+ E SL+CE S P + WY+D ++ S+
Sbjct: 5507 CSTKVIVKEPPVFSSFPPIVETLKNAEV------SLECELSGTPPFEVVWYKDKRQLRSS 5560
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+I S +S+ + NV G Y C A N++G
Sbjct: 5561 KKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG 5596
Score = 85.9 bits (211), Expect = 5e-17
Identities = 70/281 (24%), Positives = 111/281 (39%), Gaps = 18/281 (6%)
Query: 34 FNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
F + D++ V G + V+ KV W S + G + LE
Sbjct: 6836 FEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESC-----NISLE---DF 6887
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLV 152
L + +V + G Y+C V + +L V+ P +D +V GS + L
Sbjct: 6888 VTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLE 6947
Query: 153 CMANGRPEPVITW---RHLTPTGRE----FEGEEEYLEILGITREQSGKYECKAANEVSS 205
G P ++W +L + LEIL T E +Y C NE
Sbjct: 6948 ATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQ 7007
Query: 206 ADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
D+ + V+V PP E + EA G A+L+C+ P WY++ T++ SA
Sbjct: 7008 -DICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAY 7066
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+++ +SL + V G Y+C A N +G +S VL
Sbjct: 7067 KMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL 7107
Score = 85.1 bits (209), Expect = 8e-17
Identities = 59/222 (26%), Positives = 89/222 (40%), Gaps = 14/222 (6%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L + +D+ G YTC V + L V+ P SD +V G ++ L
Sbjct: 5950 LELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTY 6009
Query: 156 NGRPEPVITWRHLTPTGREFEGEEE----------YLEILGITREQSGKYECKAANEVSS 205
G +TW+ G E+ LEIL T+ +G+Y C+ NE
Sbjct: 6010 TGTLPISVTWKK---DGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGR 6066
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ T+ P +TE + EA G SL+C+ + P WY+ DT++
Sbjct: 6067 DVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYR 6126
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFR 307
T ++L V G YTC A N +G T +S +FR
Sbjct: 6127 TYFTNNVATLVFNKVNINDSGEYTCKAENSIG-TASSKTVFR 6167
Score = 83.2 bits (204), Expect = 3e-16
Identities = 62/258 (24%), Positives = 107/258 (41%), Gaps = 21/258 (8%)
Query: 51 LRCVV-EDKNSKVAWLNRSGIIFAGHD-KWSLDPRVELEKRHSLEYSLRIQKVDVYDEGS 108
L C V ED+ V W + G D K + ++ +L I + D G+
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIA---------TLEIPLAKLKDSGT 3713
Query: 109 YTCSVQTQHEPKTSQVYLIVQVPPK-ISNISSDVTVNEGSNVTLVCMANGRPEPVITW-- 165
Y C+ + + + V+ PP + + + G + L C G P +TW
Sbjct: 3714 YVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFK 3773
Query: 166 --RHLTPTGRE---FEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPT 220
+ L+ + F E L+I + E SG Y C+A N+V S D ++ + PP+
Sbjct: 3774 NNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGS-DSCSTEIVIKEPPS 3832
Query: 221 ITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTN 279
++ + + G A L+CE S + W++D +I S+ + S + L + +
Sbjct: 3833 FIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFS 3892
Query: 280 VTEEHYGNYTCVAANKLG 297
G Y CV AN++G
Sbjct: 3893 FNSADVGEYECVVANEVG 3910
Score = 82.8 bits (203), Expect = 4e-16
Identities = 55/218 (25%), Positives = 94/218 (43%), Gaps = 9/218 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L + VD G YTC V + + +L ++ P K +D ++ +G + L
Sbjct: 7832 LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTF 7891
Query: 156 NGRPEPVITWR----HLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSSADV 208
G P +TW+ ++TP+ R + LEI T E +G+Y C N S D
Sbjct: 7892 TGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIEN-ASGKDS 7950
Query: 209 KQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
++ + PP + + + + + G ASL+C+ + P WY+ DT++ ++
Sbjct: 7951 CSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMH 8010
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
++L V G Y C A N +G +AS L
Sbjct: 8011 FRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFL 8048
Score = 81.6 bits (200), Expect = 9e-16
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 17/225 (7%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK-----ISNISSDVTVNEGSNV 149
+L+I + D+ G Y+CS +S L + P K I +S DV E ++
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADF 6290
Query: 150 TLVCMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANE 202
C G ITW + + P G G +L IL + + SG+Y C+A N+
Sbjct: 6291 E--CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATND 6348
Query: 203 VSSADVKQVKVTVNYPPTITES--KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
V D+ +++V PP + S A G L+C+ S P W+R+D+ ++
Sbjct: 6349 VGK-DMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHE 6407
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + + LT+ + E G+Y C A N +G + S L
Sbjct: 6408 SWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTAL 6452
Score = 79.7 bits (195), Expect = 3e-15
Identities = 73/304 (24%), Positives = 117/304 (38%), Gaps = 29/304 (9%)
Query: 40 NITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQ 99
++T G A C V + G + W + + E +H LE S
Sbjct: 3559 SLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRIS---DAENKHILELS---- 3611
Query: 100 KVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRP 159
+ + D G Y+C + Q LI+ P V V L C +
Sbjct: 3612 NLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDR 3671
Query: 160 EPVITWR---HLTPTGRE----FEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK 212
+ +TW P G++ FE + LEI + SG Y C A+NE S+
Sbjct: 3672 KVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSAT- 3730
Query: 213 VTVNYPPTITES--KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
VTV PP+ + S G A L C+ P W++++ ++ +N + +
Sbjct: 3731 VTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVN 3790
Query: 271 GQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS--LVLFRPGS----------VRGINGSI 318
++ L +T+V E G+Y+C A N +G + S +V+ P S VRG N +
Sbjct: 3791 SEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALL 3850
Query: 319 SLAV 322
V
Sbjct: 3851 QCEV 3854
Score = 79.0 bits (193), Expect = 6e-15
Identities = 56/217 (25%), Positives = 88/217 (40%), Gaps = 10/217 (4%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV-NEGSNVTLVC 153
SL + D G+Y C + TS+ L V+ PP+ S V V G + T C
Sbjct: 4824 SLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFEC 4883
Query: 154 MANGRPEPVITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
G P+ ++W + G F +I G E SG Y C+A N+ +A
Sbjct: 4884 QITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTA 4943
Query: 207 DVKQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+++ V PPT I E K E L+CE + P + W +++ I S+
Sbjct: 4944 SC-SIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYT 5002
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+ +L +T G Y C+ +N+ G + S
Sbjct: 5003 LTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCS 5039
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/222 (25%), Positives = 94/222 (42%), Gaps = 12/222 (5%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
+L+ K + + G Y C ++ + + L+V P I + +TV G TL C
Sbjct: 5667 TLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECK 5726
Query: 155 ANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
G PE + W + LT + + F + L IL + R+ +G Y + N V +
Sbjct: 5727 VAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSS 5786
Query: 208 VKQVKVTVN---YPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
V V V+ PP+ T K+ G L+C+ + W+ + T+I S
Sbjct: 5787 CTAV-VDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAK 5845
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ ++ +L + ++ GNYTCVAAN G VL
Sbjct: 5846 YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL 5887
Score = 77.8 bits (190), Expect = 1e-14
Identities = 66/278 (23%), Positives = 108/278 (38%), Gaps = 22/278 (7%)
Query: 34 FNRGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
F + + + V GD+A L+C + V+W + G K ++ R+++
Sbjct: 7963 FVKQLEPVKVSVGDSASLQCQLAGTPEIGVSW-------YKGDTKLRPTTTYKMHFRNNV 8015
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ---VPPKISNISSDVTVNEGSNV 149
+L +VD+ D G Y C + ++ +L VQ +PP S DV G V
Sbjct: 8016 A-TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPV 8074
Query: 150 TLVCMANGRPEPVITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANE 202
C +G ++W + F L I R +G+Y C A N
Sbjct: 8075 VFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNP 8134
Query: 203 VSSADVK-QVKVTVNYPPTITESKSN--EATTGRQASLKCEASAVPAPDFEWYRDDTRIN 259
+ SA ++ +T P + + +A G A +C + W +D I
Sbjct: 8135 IGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIR 8194
Query: 260 SANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
S +I E + LTV V + G YTC A N++G
Sbjct: 8195 SGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVG 8232
Score = 77.4 bits (189), Expect = 2e-14
Identities = 62/277 (22%), Positives = 114/277 (41%), Gaps = 28/277 (10%)
Query: 43 VRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS-----L 96
+++GD L C V K+ W ++ D ++ +H + + L
Sbjct: 4311 LKKGDATQLACKVTGTPPIKITW-------------FANDREIKESSKHRMSFVESTAVL 4357
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
R+ V + D G Y C Q + +IV+ P + + V + +V L+
Sbjct: 4358 RLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVA 4417
Query: 157 GRPEPVITW---RHLTPTGREF----EGEEEYLEILGITREQSGKYECKAANEVSSADVK 209
G P ITW + +GR++ + L+IL +G+Y+C+ NEV S+ +
Sbjct: 4418 GTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSS-IC 4476
Query: 210 QVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKS 268
+VT+ PP+ I + +S + G A+ + W +D I + + +
Sbjct: 4477 SARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTF 4536
Query: 269 TEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+SL ++ + +H G Y C A N G+ S +L
Sbjct: 4537 ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573
Score = 76.6 bits (187), Expect = 3e-14
Identities = 56/226 (24%), Positives = 89/226 (39%), Gaps = 20/226 (8%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
+L+ +V+ + G YTC ++ + L V P I + V G TL C
Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECT 7608
Query: 155 ANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVS 204
G PE W G+E + +Y L+I+ + SG Y + N V
Sbjct: 7609 VAGTPELSTKW---FKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG 7665
Query: 205 ----SADVKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRIN 259
+A ++ TV PP+ T K +G ++C+ P W+ + I+
Sbjct: 7666 KDSCTASLQVSDRTV--PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEIS 7723
Query: 260 SANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
S + T+ +LTV + E G+YTC+A N G S L
Sbjct: 7724 SGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPL 7769
Score = 76.6 bits (187), Expect = 3e-14
Identities = 60/237 (25%), Positives = 98/237 (41%), Gaps = 28/237 (11%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP---PKISNISSDVTVNEGSNVTLV 152
L+++K + D G YTC V ++++ P P + VTV+EG V L
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLS 8366
Query: 153 CMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
C G I W R + P+ R F LE+ + + SG Y CKA+N V+
Sbjct: 8367 CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASN-VAG 8425
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGR----------------QASLKCEASAVPAPDF 249
+D + KVT+ P + + A GR A+ + P P+
Sbjct: 8426 SDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNV 8485
Query: 250 EWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+W + R +N + I ++ L + + T+ G Y CVA N+ G +++ L
Sbjct: 8486 KWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNL 8542
Score = 76.3 bits (186), Expect = 4e-14
Identities = 65/274 (23%), Positives = 109/274 (39%), Gaps = 22/274 (8%)
Query: 46 GDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVY 104
G+ A L+C V+ +++W + H K P +++ ++++ SL I KVD
Sbjct: 7034 GEPATLQCKVDGTPEIRISW-------YKEHTKLRSAPAYKMQFKNNVA-SLVINKVDHS 7085
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIV---QVPPKISNISSDVTVNEGSNVTLVCMANGRPEP 161
D G Y+C S L++ ++PP + DV G V C NG
Sbjct: 7086 DVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPL 7145
Query: 162 VITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEV--SSADVKQVK 212
++W + F L+IL + G+Y C A+N + +S+ K +
Sbjct: 7146 QVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLIL 7205
Query: 213 VTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEG 271
PP + S + G + KC + W +D+ I ++ E
Sbjct: 7206 SEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVEN 7265
Query: 272 QSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
++LTV V + G YTC A+N G + S L
Sbjct: 7266 TATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQL 7299
Score = 75.9 bits (185), Expect = 5e-14
Identities = 59/253 (23%), Positives = 103/253 (40%), Gaps = 23/253 (9%)
Query: 78 WSLDPR-VELEKRHSLEY-----SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP 131
W LD + ++H + + + +I V + G+Y C + + + L V+ P
Sbjct: 4895 WYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEP 4954
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY---------- 181
P V V + S+V L C G P +TW RE ++Y
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTW---LKNNREIRSSKKYTLTDRVSVFN 5011
Query: 182 LEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQ-ASLKCE 240
L I +G+Y+C +NE S +V + PP+ + N T + A+ +
Sbjct: 5012 LHITKCDPSDTGEYQCIVSNEGGSCSCS-TRVALKEPPSFIKKIENTTTVLKSSATFQST 5070
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
+ P W +DD ++ + + I + ++L + +V H G YTC A N+ GV
Sbjct: 5071 VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130
Query: 301 --ASLVLFRPGSV 311
A L++ P +
Sbjct: 5131 CYAFLLVQEPAQI 5143
Score = 75.9 bits (185), Expect = 5e-14
Identities = 56/212 (26%), Positives = 79/212 (37%), Gaps = 10/212 (4%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK-ISNISSDVTVNEGSNVTLVC 153
+L + KV D G YTC + L VQ PP+ I + V + C
Sbjct: 7268 TLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYEC 7327
Query: 154 MANGRPEPVITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
G PE + W + + F LE+ ++ E SG Y C+A N SA
Sbjct: 7328 KIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSA 7387
Query: 207 DVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ V PP + E G L+CE P WY+D + S +
Sbjct: 7388 S-SSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYK 7446
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
I S +S+ + NV G Y C A N +G
Sbjct: 7447 IMSENFLTSIHILNVDAADIGEYQCKATNDVG 7478
Score = 75.1 bits (183), Expect = 8e-14
Identities = 60/243 (24%), Positives = 95/243 (39%), Gaps = 11/243 (4%)
Query: 89 RHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK-ISNISSDVTVNEGS 147
+ +LE SL + V D G+YTC V L V+ P + + + +G
Sbjct: 4256 KEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGD 4315
Query: 148 NVTLVCMANGRPEPVITW----RHLTPTGREFEGEEEYLEILGITR---EQSGKYECKAA 200
L C G P ITW R + + + E +L +T E SG+Y C+A
Sbjct: 4316 ATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQ 4375
Query: 201 NEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
NE S + + P E K E L E + P + W++D+T + S
Sbjct: 4376 NEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRS 4435
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRPGS-VRGINGS 317
+ + SL + G Y C N++G + +A + L P S ++ I +
Sbjct: 4436 GRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIEST 4495
Query: 318 ISL 320
SL
Sbjct: 4496 SSL 4498
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/208 (25%), Positives = 79/208 (37%), Gaps = 10/208 (4%)
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
D G Y+C ++ + + PP + G +V+L C G PE ++
Sbjct: 6052 DAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVS 6111
Query: 165 W----RHLTPTGRE---FEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVN- 216
W L PT F L + SG+Y CKA N + +A K V
Sbjct: 6112 WYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQER 6171
Query: 217 -YPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSS 274
PP+ K E T G +L C + WYRD + L+ + ++
Sbjct: 6172 QLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVAT 6231
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNAS 302
L + H G Y+C A+N LG ++S
Sbjct: 6232 LKILQTDLSHSGQYSCSASNPLGTASSS 6259
Score = 73.6 bits (179), Expect = 2e-13
Identities = 54/227 (23%), Positives = 98/227 (43%), Gaps = 12/227 (5%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L + + V D G YTC +S L V+ PP + +G++V L C
Sbjct: 7363 LEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECEL 7422
Query: 156 NGRPEPVITW---RHLTPTGREFEGEEEY----LEILGITREQSGKYECKAANEVSSADV 208
G P ++W + +G++++ E + IL + G+Y+CKA N+V S D
Sbjct: 7423 QGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGS-DT 7481
Query: 209 KQVKVTVNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRI-NSANGLEI 266
+ + PP + S+ +T G++ L+ W++D I ++ + I
Sbjct: 7482 CVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWI 7541
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN--ASLVLFRPGSV 311
+E ++L + V + G YTC N G+ A+L + P ++
Sbjct: 7542 SYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATI 7588
Score = 72.4 bits (176), Expect = 5e-13
Identities = 76/316 (24%), Positives = 126/316 (39%), Gaps = 27/316 (8%)
Query: 34 FNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
F + D++ G T L+ V V W+ +I D ++++ + +
Sbjct: 3926 FVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIRE-------DGKIKMSFSNGV 3978
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLV 152
L I V + G YTC + + +TS LIV+ P KI + + V G TL
Sbjct: 3979 AV-LIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLE 4037
Query: 153 CMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
G PE W R L + + F+ L+ SG+Y + +NEV S
Sbjct: 4038 YTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGS 4097
Query: 206 ADVKQVKVTV--NYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ + + + P T+ N ++ L C+ + W++D I +++
Sbjct: 4098 SSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASD 4157
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS--LVLFRPGSVRGINGSISL 320
I EG +SL + V GN+TC A N +G ++S L++ P S GS
Sbjct: 4158 RYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKD- 4216
Query: 321 AVPLWLLAASLLCLLS 336
+L S +CL S
Sbjct: 4217 -----VLPGSAVCLKS 4227
Score = 72.0 bits (175), Expect = 7e-13
Identities = 52/220 (23%), Positives = 83/220 (37%), Gaps = 10/220 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I + + D Y+C ++ + + + V PP V G TL C
Sbjct: 6984 LEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKV 7043
Query: 156 NGRPEPVITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEV---SS 205
+G PE I+W R +F+ L I + G+Y CKA N V +S
Sbjct: 7044 DGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVAS 7103
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ V +K P + K T G + +C + WY+D + L+
Sbjct: 7104 SAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQ 7163
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
++L + + H G Y C A+N LG ++S L
Sbjct: 7164 TSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/219 (23%), Positives = 86/219 (39%), Gaps = 10/219 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I +++ D G+YTCS + +L V+ PP VN + V L +
Sbjct: 4732 LEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALV 4791
Query: 156 NGRPEPVITW----RHLTPTGREFEGEEEY---LEILGITREQSGKYECKAANEVSSADV 208
G I W + L +++ LE+ SG Y C+ +N+V +A
Sbjct: 4792 GGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATS 4851
Query: 209 KQVKVTVNYPPTITESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
K + V PP + S G+ + +C+ + P WY D I + I
Sbjct: 4852 KAT-LFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGI 4910
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+G ++ ++ E+ G Y C A N G + S+ L
Sbjct: 4911 SFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 4949
Score = 70.9 bits (172), Expect = 2e-12
Identities = 61/264 (23%), Positives = 115/264 (43%), Gaps = 23/264 (8%)
Query: 32 VDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHS 91
V+F R ++ VR+ + A C + +N+KV W I G + ++ + +
Sbjct: 12374 VEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGK-------KYDIISKGA 12426
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
+ L I K + DE Y+C V+T +TS + +++ + +++ V+E + L
Sbjct: 12427 VRI-LVINKCLLDDEAEYSCEVRTA---RTSGMLTVLEEEAVFTKNLANIEVSETDTIKL 12482
Query: 152 VCMANGRPEPVITW----RHLTPTGRE---FEGEEEYLEILGITREQSGKYECKAANEVS 204
VC + +P + W + TGR EG + L I E +G Y C+ + +
Sbjct: 12483 VCEVS-KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRT 12541
Query: 205 SADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
VK ++ + I++ ++ E G +A C S P +W RDD + S +
Sbjct: 12542 DGKVKVHELAAEF---ISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKY 12597
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNY 288
++ + + L V + T + G Y
Sbjct: 12598 DVIADGKKRVLVVKDATLQDMGTY 12621
Score = 69.7 bits (169), Expect = 3e-12
Identities = 62/267 (23%), Positives = 96/267 (35%), Gaps = 24/267 (8%)
Query: 46 GDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVY 104
GD+ L+C V V+W + G K P +++ +L KV++
Sbjct: 6093 GDSVSLQCQVAGTPEITVSW-------YKGDTKLRPTPEYRTYFTNNVA-TLVFNKVNIN 6144
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIV---QVPPKISNISSDVTVNEGSNVTLVCMANGRPEP 161
D G YTC + +S+ + Q+PP + D+ G VTL C NG
Sbjct: 6145 DSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPI 6204
Query: 162 VITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT 214
+ W R F L+IL SG+Y C A+N + +A ++T
Sbjct: 6205 QVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTAS-SSARLT 6263
Query: 215 VNYPPTI----TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
P + S + G A +C + W +D+ I I
Sbjct: 6264 AREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVG 6323
Query: 271 GQSSLTVTNVTEEHYGNYTCVAANKLG 297
L + V + G YTC A N +G
Sbjct: 6324 NTPHLRILKVGKGDSGQYTCQATNDVG 6350
Score = 69.7 bits (169), Expect = 3e-12
Identities = 49/217 (22%), Positives = 81/217 (37%), Gaps = 10/217 (4%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
L I V D G Y C ++ + +++ PP V V+ G + +L C
Sbjct: 7925 LEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQL 7984
Query: 156 NGRPEPVITW-------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAAN---EVSS 205
G PE ++W R T F L + SG+Y CKA N EVS+
Sbjct: 7985 AGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSA 8044
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
+ V+ P + + + T G C S WY+D + + ++
Sbjct: 8045 STFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQ 8104
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+ ++L + G Y+C A N +G ++S
Sbjct: 8105 TSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSS 8141
Score = 68.6 bits (166), Expect = 8e-12
Identities = 63/280 (22%), Positives = 113/280 (40%), Gaps = 24/280 (8%)
Query: 36 RGTDNITVRQGDTAILRCVVEDK-NSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
R + + V G A C ++ N + W I+ DK S+ S +Y
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES-DKCSI---------RSSKY 3509
Query: 95 --SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ--VPPKISNISSDVTVNEGSNVT 150
SL I + V D G YTC ++ + L V PP + +T G
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569
Query: 151 LVCMANGRPEPVITWRH------LTPTGREFEGEEEY-LEILGITREQSGKYECKAANEV 203
+C G P W+ +P R + E ++ LE+ +T + G Y CKA+N+
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 204 SSADVKQVK-VTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
AD+ Q + + ++ P I E + ++ ++ L+C+ W +D ++
Sbjct: 3630 -GADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGK 3688
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
+I + ++L + + G Y C A+N+ G ++ S
Sbjct: 3689 DYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCS 3728
Score = 68.2 bits (165), Expect = 1e-11
Identities = 68/275 (24%), Positives = 106/275 (38%), Gaps = 26/275 (9%)
Query: 46 GDTAILRCVVED-KNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVY 104
GD LR +VE + V WL G + + S + R+ + +L++ +
Sbjct: 6565 GDAVELRAIVEGFQPISVVWLKDRGEVI----RESENTRISFIDNIA---TLQLGSPEAS 6617
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVIT 164
+ G Y C ++ + L V P +I +TV G+ L C+ G PE
Sbjct: 6618 NSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAK 6677
Query: 165 WRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVSSADVKQVKVT 214
W GRE + ++ L+I G Y + N V ++ V V
Sbjct: 6678 W---FKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCT-VSVH 6733
Query: 215 VN---YPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
V+ PP+ I + K A G L+C S W++D I S + +E
Sbjct: 6734 VSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE 6793
Query: 271 GQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+L ++ + G YTCVAAN G S VL
Sbjct: 6794 NVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVL 6828
Score = 67.8 bits (164), Expect = 1e-11
Identities = 56/254 (22%), Positives = 105/254 (41%), Gaps = 24/254 (9%)
Query: 62 VAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKT 121
V WL S D+ + D + + +++ SL + ++V +G Y C + +
Sbjct: 4517 VTWLKDS-------DEITEDDNIRMTFENNVA-SLYLSGIEVKHDGKYVCQAKNDAGIQR 4568
Query: 122 SQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY 181
L V+ P I+ + + V +G TL +G E W G+E +Y
Sbjct: 4569 CSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKW---FKDGQELTLGSKY 4625
Query: 182 ----------LEILGITREQSGKYECKAANEV--SSADVKQVKVTVNYPPTITES-KSNE 228
L+I+ ++ SG+Y + N+V SS + + + PP+ T+ K +
Sbjct: 4626 KISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMD 4685
Query: 229 ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNY 288
+ G L+C + +W++DD I+++ + + + L ++ + G Y
Sbjct: 4686 SIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTY 4745
Query: 289 TCVAANKLGVTNAS 302
TC A NK G S
Sbjct: 4746 TCSATNKAGHNQCS 4759
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 13/223 (5%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV---QVPPKISNISSDVTVNEGSNVTL 151
+L+I + D G Y CS +S LI+ +VPP V + G + T
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231
Query: 152 VCMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVS 204
C G ITW R + P G L +L + + +G+Y C A+N ++
Sbjct: 7232 KCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASN-IA 7290
Query: 205 SADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFE--WYRDDTRINSAN 262
D ++ V PP + + + E +P+ + WY+D+T I ++
Sbjct: 7291 GKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESS 7350
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ + + L + N++ E G+YTC A N G ++S L
Sbjct: 7351 KFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSL 7393
Score = 67.0 bits (162), Expect = 2e-11
Identities = 67/282 (23%), Positives = 107/282 (37%), Gaps = 29/282 (10%)
Query: 40 NITVRQGDTAILRCVVEDKNS-KVAWL-NRSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
++ V + D L CVV KV WL + I+ + + S + V S R
Sbjct: 5149 SVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVA---------SFR 5199
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV---QVPPKISNISSDVTVNEGSNVTLVCM 154
IQ V D G YT V+ + YL V +PP + + + GS++ + C
Sbjct: 5200 IQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECK 5259
Query: 155 ANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVS 204
+G W G+E +Y LE+ + E + Y CK +N V+
Sbjct: 5260 VSGSLPISAQW---FKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSN-VA 5315
Query: 205 SADVKQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
D +TV PP+ + + +A K P +W++DD + S
Sbjct: 5316 GDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPK 5375
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
I S L + +V G YTC N +G + + +L
Sbjct: 5376 CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Score = 66.2 bits (160), Expect = 4e-11
Identities = 61/241 (25%), Positives = 95/241 (39%), Gaps = 22/241 (9%)
Query: 75 HDKWSLDPRVELEKRHSLEY---------SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVY 125
H W D R E R +Y S+ I VD D G Y C T
Sbjct: 7429 HVSWYKDKR---ELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGS 7485
Query: 126 LIVQVPPKISNISSDVTVNEGSNVTLVCMANG-RPEPVITWRHLTPTGREFEG----EEE 180
+ ++ PP+ SD++ G V L G P V+ ++ RE + E
Sbjct: 7486 IALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSE 7545
Query: 181 YLEILGITREQ---SGKYECKAANEVSSADVKQVKVTVNYPPTITES-KSNEATTGRQAS 236
+ L +R + +GKY C+ N+ + ++V P TI E +S + TTG +
Sbjct: 7546 NIATLQFSRVEPANAGKYTCQIKNDAGMQEC-FATLSVLEPATIVEKPESIKVTTGDTCT 7604
Query: 237 LKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKL 296
L+C + P +W++D + S N +I S L + NV G Y+ N +
Sbjct: 7605 LECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPV 7664
Query: 297 G 297
G
Sbjct: 7665 G 7665
Score = 66.2 bits (160), Expect = 4e-11
Identities = 59/282 (20%), Positives = 103/282 (36%), Gaps = 25/282 (8%)
Query: 39 DNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
++I V GDT L C V + G +K+ + ++ L+I
Sbjct: 7593 ESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVS-------GLKI 7645
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ---VPPKISNISSDVTVNEGSNVTLVCMA 155
V D G Y+ VQ + L V VPP + + GS+V + C
Sbjct: 7646 INVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKV 7705
Query: 156 NGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVSS 205
G P ++W H G E +Y L + + SG Y C A N ++
Sbjct: 7706 YGSPPISVSWFH---EGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATN-MAG 7761
Query: 206 ADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
+D +TV PP+ + + TG + P W++ + + +
Sbjct: 7762 SDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRC 7821
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+ + + L + +V G YTC+ +N+ G + + L+
Sbjct: 7822 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLY 7863
Score = 65.9 bits (159), Expect = 5e-11
Identities = 55/229 (24%), Positives = 97/229 (42%), Gaps = 20/229 (8%)
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
LEY R++ ++ E ++ EP T + + +Q P + + + V SN TL
Sbjct: 30893 LEYEFRVKCENLGGESEWS----EISEPITPKSDVPIQAPHFKEELRN-LNVRYQSNATL 30947
Query: 152 VCMANGRPEPVITW----RHLTPTG-----REFEGEEEYLEILGITREQSGKYECKAANE 202
VC G P+P++ W + + G +EF+G L I +T + + Y+ +A N+
Sbjct: 30948 VCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQ 31007
Query: 203 VSSAD-----VKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTR 257
S +V ++ P T+ + A G S+K S P P W +
Sbjct: 31008 GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDL 31067
Query: 258 INSANGLEIKSTEGQSSLTVTN-VTEEHYGNYTCVAANKLGVTNASLVL 305
I++ ++ T +SL N V + G Y A N+ G+ ++ L
Sbjct: 31068 IDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVEL 31116
Score = 65.5 bits (158), Expect = 7e-11
Identities = 49/222 (22%), Positives = 87/222 (39%), Gaps = 10/222 (4%)
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
H SL + +++ D +YTC V L V+ PP S V
Sbjct: 5288 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTV 5347
Query: 150 TLVCMANGRPEPVITWR----HLTPTGREF---EGEEEYLEILGITREQSGKYECKAANE 202
+ G P I W L + F EG +L + + ++G+Y C N+
Sbjct: 5348 EFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTND 5407
Query: 203 VSSADVKQVKVTVNYPPTITES--KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
V S D + V PP + S G + L+C+ + P W+R++ + +
Sbjct: 5408 VGS-DSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPA 5466
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
++ + + + + + N++ E G++ C A N G T+ S
Sbjct: 5467 SDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCS 5508
Score = 64.3 bits (155), Expect = 1e-10
Identities = 64/279 (22%), Positives = 106/279 (37%), Gaps = 23/279 (8%)
Query: 41 ITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHD-KWSLDPRVELEKRHSLEYSLRI 98
+TV G+T L C V V W ++ + K+S ++ SLRI
Sbjct: 5713 MTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKIS---------SLRI 5763
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ---VPPKISNISSDVTVNEGSNVTLVCMA 155
V+ D G+YT VQ + + V VPP + + G++ L C
Sbjct: 5764 LSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKV 5823
Query: 156 NGRPEPVITWRHLTP---TGREFEGEEE----YLEILGITREQSGKYECKAANEVSSADV 208
G + W H +G +++ L++ + G Y C AAN S +
Sbjct: 5824 AGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883
Query: 209 KQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ V +TV PP+ + E + E G+ + P W+R + + I
Sbjct: 5884 RAV-LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIY 5942
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+ + L + N+ G YTCV +N G + + LF
Sbjct: 5943 FEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLF 5981
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/215 (21%), Positives = 78/215 (36%), Gaps = 13/215 (6%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLV 152
E L I V V D GSY+C + ++++ PP + G+N L
Sbjct: 3792 EAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQ 3851
Query: 153 CMANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANE 202
C +G I+W ++ ++Y LEI G+YEC ANE
Sbjct: 3852 CEVSGTGPFEISW---FKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANE 3908
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
V + P + + A G+ +L+ W + I
Sbjct: 3909 VGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDG 3968
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+++ + G + L + +V G YTC+A N+ G
Sbjct: 3969 KIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAG 4003
Score = 63.2 bits (152), Expect = 3e-10
Identities = 68/305 (22%), Positives = 118/305 (38%), Gaps = 49/305 (16%)
Query: 41 ITVRQGDTAILRCVVEDK-NSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQ 99
+TV+ G A V+ + K++W ++ G L EY+L +
Sbjct: 3248 VTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL--------HDGQEYTLLLI 3299
Query: 100 KVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP-------------PKISNISSDVTVNEG 146
+ D YTC + + T+ L V+VP P I D +EG
Sbjct: 3300 EAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEG 3359
Query: 147 SNVTLVCMANGRPEPVITW----RHLTPTG--REFEGEEEY-LEILGITREQSGKYECKA 199
C +G + ++W + + P+ R + E+ Y LEI E G Y A
Sbjct: 3360 QPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA 3418
Query: 200 ANEV----SSADV--------------KQVKVTVNYPPTITES-KSNEATTGRQASLKCE 240
+N V S+A++ +++++ + P I + E G A CE
Sbjct: 3419 SNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478
Query: 241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
+ P F+W++ I ++ I+S++ SSL + G YTC A+N+ G +
Sbjct: 3479 IQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVS 3538
Query: 301 ASLVL 305
+ L
Sbjct: 3539 CTATL 3543
Score = 62.4 bits (150), Expect = 6e-10
Identities = 47/219 (21%), Positives = 84/219 (38%), Gaps = 8/219 (3%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
S+ I VD D G Y C Q + T + ++ PP+ + + +TV G L
Sbjct: 5573 SIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQAS 5632
Query: 155 ANGRPEPVITW-RHLTPTGREFEG-------EEEYLEILGITREQSGKYECKAANEVSSA 206
G + W + RE E L+ +GKY C+ N+
Sbjct: 5633 IEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMR 5692
Query: 207 DVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
+ + + + ++ T G +L+C+ + P EWY+D + S+ +
Sbjct: 5693 ENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKF 5752
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
SSL + +V + G YT N +G ++ + V+
Sbjct: 5753 SFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVV 5791
Score = 61.6 bits (148), Expect = 1e-09
Identities = 48/190 (25%), Positives = 71/190 (37%), Gaps = 12/190 (6%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH---------LTPTGREFEGEEEYL 182
P + V V EGS T +G P P ++W L F L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 183 EILGITREQSGKYECKAAN---EVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKC 239
I +T+ SG+Y KA N + +S VK P + +S G Q L+
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 240 EASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
+ +P P ++YRD I S+ +I SL + E G Y+ A N +G
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 300 NASLVLFRPG 309
++ L G
Sbjct: 186 TSTAELLVQG 195
Score = 61.2 bits (147), Expect = 1e-09
Identities = 61/283 (21%), Positives = 103/283 (36%), Gaps = 29/283 (10%)
Query: 40 NITVRQGDTAILRCVVED-KNSKVAWLNRSGIIFAGH-------DKWSLDPRVELEKRHS 91
+I V QGD A L+ K W + G D S+ + EK+ S
Sbjct: 4587 SIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDS 4646
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
EY+ +Q D G +C + L + +PP + + +GS + L
Sbjct: 4647 GEYTFEVQN----DVGRSSCKARIN--------VLDLIIPPSFTKKLKKMDSIKGSFIDL 4694
Query: 152 VCMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVS 204
C+ G I W + ++ + + F +LEI + SG Y C A N+
Sbjct: 4695 ECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754
Query: 205 SADVKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
+TV PP E +S + + LK +W++D+ ++S
Sbjct: 4755 HNQCSG-HLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAA 4813
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
+ + +SL + G Y C +N +G + LF
Sbjct: 4814 RSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLF 4856
Score = 60.1 bits (144), Expect = 3e-09
Identities = 52/249 (20%), Positives = 88/249 (35%), Gaps = 22/249 (8%)
Query: 77 KWSLDPR-VELEKRHSLEYS-----LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV-- 128
KW D R + K++ + + L+ +++D G YT + + + + V
Sbjct: 4049 KWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLD 4108
Query: 129 -QVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY------ 181
+ P + +V L C G ++W G+E + Y
Sbjct: 4109 RDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSW---FKDGKEIAASDRYRIAFVE 4165
Query: 182 ----LEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASL 237
LEI+ + +G + C+A N V S D + P +T+ S + G L
Sbjct: 4166 GTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL 4225
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
K W++ + + S I +SSL + V G YTC +N G
Sbjct: 4226 KSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAG 4285
Query: 298 VTNASLVLF 306
S LF
Sbjct: 4286 GVECSANLF 4294
Score = 59.7 bits (143), Expect = 4e-09
Identities = 46/203 (22%), Positives = 83/203 (40%), Gaps = 9/203 (4%)
Query: 112 SVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPT 171
S+ + KTSQ V+ +I S+ +++NEG + L G + + T
Sbjct: 33019 SIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELT 33078
Query: 172 GRE-----FEGEEEYLEILGITREQSGKYECKAANEVSSA----DVKQVKVTVNYPPTIT 222
E G ++ L I + G C + + D+ K + P I+
Sbjct: 33079 NSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFIS 33138
Query: 223 ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTE 282
+ +S G+ CE S P+P+ EW++++ I+ ++ + I + SL + N +
Sbjct: 33139 QPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASV 33198
Query: 283 EHYGNYTCVAANKLGVTNASLVL 305
G YT A N G +A+ L
Sbjct: 33199 SDSGKYTIKAKNFRGQCSATASL 33221
Score = 59.3 bits (142), Expect = 5e-09
Identities = 46/186 (24%), Positives = 68/186 (36%), Gaps = 17/186 (9%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREF----------EGEEEY 181
P I DVT G L C GRP P I W G+E +G
Sbjct: 30533 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRF---GKELIQSRKYKMSSDGRTHT 30589
Query: 182 LEILGITREQSGKYECKAANEVSSADVKQ---VKVTVNYPPTITESKSNEATTGRQASLK 238
L ++ +E G Y C A NEV + ++ T + P + G L
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLH 30649
Query: 239 CEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEE-HYGNYTCVAANKLG 297
P P W+ + ++ + I++TE + L + NV + H G Y +N G
Sbjct: 30650 VMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFG 30709
Query: 298 VTNASL 303
+A L
Sbjct: 30710 TVDAIL 30715
Score = 57.8 bits (138), Expect = 1e-08
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 19/207 (9%)
Query: 94 YSLRIQKVDVYDEGSY--TCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
++LR++ + D+G+Y C P + L V + P DVT+ EG T+
Sbjct: 8712 HTLRVKNCQLKDQGNYRLVCG------PHIASAKLTV-IEPAWERHLQDVTLKEGQTCTM 8764
Query: 152 VC---MANGRPEPVITWRHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
C + N + E R L P GR E E + L I + E G+Y CK + +S
Sbjct: 8765 TCQFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETS 8824
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
A+++ + + I +E + A+ +CE S A WY+ T + +
Sbjct: 8825 AELRIEAEPIQFTKRIQNIVVSEH---QSATFECEVSFDDAI-VTWYKGPTELTESQKYN 8880
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVA 292
++ +T+ NVT + G Y+ +A
Sbjct: 8881 FRNDGRCHYMTIHNVTPDDEGVYSVIA 8907
Score = 57.8 bits (138), Expect = 1e-08
Identities = 66/277 (23%), Positives = 111/277 (40%), Gaps = 45/277 (16%)
Query: 32 VDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHS 91
V+F + ++ TV +G TA+L C V +N+KV W I K++
Sbjct: 12285 VEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILK-------------SKKYE 12331
Query: 92 LEYSLRIQKVDVY-----DEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNIS--SDVTVN 144
+ R++K+ ++ D +YTC + + KTS + VPP + + +D+ V
Sbjct: 12332 IVADGRVRKLVIHDCTPEDIKTYTCDAK---DFKTSCNLNV--VPPHVEFLRPLTDLQVR 12386
Query: 145 EGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY-------LEILGITR---EQSGK 194
E C + R + W G E + ++Y + IL I + + +
Sbjct: 12387 EKEMARFECELS-RENAKVKW---FKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 12442
Query: 195 YECKAANEVSSADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYR 253
Y C EV +A + + T++ +N E + L CE S P + WY+
Sbjct: 12443 YSC----EVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYK 12497
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
D I EI + + L + N E GNY C
Sbjct: 12498 GDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNC 12534
Score = 57.4 bits (137), Expect = 2e-08
Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 8/145 (5%)
Query: 169 TPTGREFEGEEEYLEILGI----TREQSGKYECKAANEVSSADVKQVKVTVNYP---PTI 221
TP + E E + +G+ T + ++E E + +V V P PT+
Sbjct: 886 TPDTYKSEAGVEVKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTL 945
Query: 222 TESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNV 280
N G +L+C S P+P WYR+D +I S+ +I G + L +
Sbjct: 946 VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREA 1005
Query: 281 TEEHYGNYTCVAANKLGVTNASLVL 305
E G +TC A N+ G + S L
Sbjct: 1006 FAEDSGRFTCSAVNEAGTVSTSCYL 1030
Score = 56.6 bits (135), Expect = 3e-08
Identities = 46/229 (20%), Positives = 85/229 (37%), Gaps = 9/229 (3%)
Query: 83 RVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVT 142
+ ++ +H + SL I ++ D G Y C + T + + PP+ SD +
Sbjct: 6503 KFKITSKH-FDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTS 6561
Query: 143 VNEGSNVTLVCMANGRPEPVITW--------RHLTPTGREFEGEEEYLEILGITREQSGK 194
G V L + G + W R T F L++ SGK
Sbjct: 6562 TLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGK 6621
Query: 195 YECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRD 254
Y C+ N+ + V + I + + TTG +L+C + P +W++D
Sbjct: 6622 YICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKD 6681
Query: 255 DTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
+++ + I +SL + G Y+ N +G +N ++
Sbjct: 6682 GRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTV 6730
Score = 55.1 bits (131), Expect = 9e-08
Identities = 64/286 (22%), Positives = 104/286 (36%), Gaps = 37/286 (12%)
Query: 41 ITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPR-VELEKRHSLEY----- 94
+TV G+ L CVV A KW D R + + +H + +
Sbjct: 6654 MTVTTGNPFALECVVTGTPELSA-------------KWFKDGRELSADSKHHITFINKVA 6700
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQ---VPPKISNISSDVTVNEGSNVTL 151
SL+I ++ D+G Y+ V+ V + V VPP DV G++V L
Sbjct: 6701 SLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVL 6760
Query: 152 VCMANGRPEPVITWRHLTPTGRE----------FEGEEEYLEILGITREQSGKYECKAAN 201
C +G + W G E F L + + +G Y C AAN
Sbjct: 6761 ECRVSGSAPISVGWFQ---DGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAAN 6817
Query: 202 EVSSADVKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
V+ +D +TV PP+ ++ S E G + P +W++ +
Sbjct: 6818 -VAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVP 6876
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
I + + L + V G+Y+C+ N G + + LF
Sbjct: 6877 GESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922
Score = 55.1 bits (131), Expect = 9e-08
Identities = 54/230 (23%), Positives = 89/230 (38%), Gaps = 16/230 (6%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV---QVPPKISNISSDVTVNEGSNVTL 151
+L I K D G Y+C+ +S LI+ + PP + V G +
Sbjct: 8113 TLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADF 8172
Query: 152 VCMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVS 204
C G ++W R + G+ + +L +L + + SG+Y C A NEV
Sbjct: 8173 ECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVG 8232
Query: 205 SAD-VKQVKVTVNY-PPTITE--SKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS 260
Q+ + PP+ T+ S++ E T G L+ + WY+++ I
Sbjct: 8233 KDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQP 8292
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVLFRP 308
+ EI L V G YTC +N G + +S+V+ P
Sbjct: 8293 TSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEP 8342
Score = 54.3 bits (129), Expect = 2e-07
Identities = 61/270 (22%), Positives = 101/270 (37%), Gaps = 29/270 (10%)
Query: 46 GDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS--LRIQKVD 102
G++A C V + KV+W S I +G K+ + LE S L + KVD
Sbjct: 8167 GESADFECHVTGTQPIKVSWAKDSREIRSG-GKYQIS---------YLENSAHLTVLKVD 8216
Query: 103 VYDEGSYTCSVQTQHEPKTSQVYLIVQ---VPPKISN-ISSDVTVNEGSNVTLVCMANGR 158
D G YTC + + L ++ +PP + +S V EG++ L G
Sbjct: 8217 KGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS 8276
Query: 159 PEPVITWR----HLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQV 211
+ W + PT F+ L++ +G Y CK +N+ SA +
Sbjct: 8277 QPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSA-LCTS 8335
Query: 212 KVTVNYP--PTITESKSNEATT--GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+ + P P + + T G L C +W + I ++
Sbjct: 8336 SIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFS 8395
Query: 268 STEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
G + L + +V + G+Y C A+N G
Sbjct: 8396 FASGTAVLELRDVAKADSGDYVCKASNVAG 8425
Score = 52.0 bits (123), Expect = 8e-07
Identities = 66/266 (24%), Positives = 108/266 (40%), Gaps = 25/266 (9%)
Query: 32 VDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHS 91
+DF ++TV + A CV+ + + V W II + DK+ + + K+H
Sbjct: 11486 LDFAVPLKDVTVPERRQARFECVLT-REANVIWSKGPDIIKSS-DKFDI---IADGKKHI 11540
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
L I DEG YT V+ + KTS + + K + D TV EG T
Sbjct: 11541 LV----INDSQFDDEGVYTAEVEGK---KTSARLFVTGIRLKFMSPLEDQTVKEGETATF 11593
Query: 152 VCMANGRPEPVITWRH--LTPTGR----EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
VC + V+ +++ T R EG+ LE+ +T + + + + S+
Sbjct: 11594 VCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSST 11653
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSANGL 264
A Q+KV P + A + +LKCE S VP +W++D I +
Sbjct: 11654 A---QLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPV---KWFKDGEEIVPSPKY 11707
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTC 290
IK+ + L + + G Y C
Sbjct: 11708 SIKADGLRRILKIKKADLKDKGEYVC 11733
Score = 51.6 bits (122), Expect = 1e-06
Identities = 59/285 (20%), Positives = 99/285 (34%), Gaps = 51/285 (17%)
Query: 24 PTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSK-VAWLNRSGIIFAGHDKWSLDP 82
P +PV G N+TV +G++ L C + S V W I + S+D
Sbjct: 935 PVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIES-----SIDF 989
Query: 83 RVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVT 142
++ + + L I++ D G +TCS + ++ YL VQV +
Sbjct: 990 QITFQSGIA---RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFE------- 1039
Query: 143 VNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANE 202
+ +T + T R E + + +T EQ+G E A
Sbjct: 1040 ---------------KETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAA--- 1081
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
P IT+ + G C+ P P W + + +
Sbjct: 1082 ---------------PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGY 1126
Query: 263 GLEIKSTE--GQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
++ + G+ L ++ + G YT V NK G T+AS L
Sbjct: 1127 RYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 51.6 bits (122), Expect = 1e-06
Identities = 63/283 (22%), Positives = 106/283 (37%), Gaps = 42/283 (14%)
Query: 27 LPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSK-VAWLNRSGIIFAGHDKWSLDPRVE 85
L V +V + N+TV + A+ + N K V W+ ++G++ ++K+++ +
Sbjct: 2702 LKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWI-KNGVVLESNEKYAISVKGT 2760
Query: 86 LEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNE 145
+ YSLRI+ + DE Y + V + KI DVT E
Sbjct: 2761 I-------YSLRIKNCAIVDESVYGFRLGRLGASARLHVETV-----KIIKKPKDVTALE 2808
Query: 146 GSNVTLVCMANGRPEPVITWRH----LTPTGRE---FEGEEEYLEILGITREQSGKY--- 195
+ V + PV W H + P+ + E + L + I+ +G+Y
Sbjct: 2809 NATVAFEVSVSHDTVPV-KWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAV 2867
Query: 196 ----ECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEW 251
ECKA V + + + + P T T AS +CE S P W
Sbjct: 2868 VGQLECKAKLFVETLHITKTMKNIEVPETKT------------ASFECEVSHFNVPSM-W 2914
Query: 252 YRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAAN 294
++ I + +I L + N + E YT V N
Sbjct: 2915 LKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 8/108 (7%)
Query: 210 QVKVTVNYPPTITESKSNEATT-GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKS 268
+ K+T P I + + T G A L C+ P PD +WYR + + ++ S
Sbjct: 30524 KTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 30583
Query: 269 TEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNASLVL-----FRPG 309
+LTV +E G YTC+A N++G T++ L+L F PG
Sbjct: 30584 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG 30631
Score = 50.8 bits (120), Expect = 2e-06
Identities = 48/220 (21%), Positives = 87/220 (39%), Gaps = 25/220 (11%)
Query: 102 DVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEP 161
+VYD Y C + + + +++ PP+ + + T G NV PEP
Sbjct: 31663 EVYD---YYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 31719
Query: 162 VITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVSSADVK-Q 210
+TW + + +++Y L I +T + +Y A N+ K +
Sbjct: 31720 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 31779
Query: 211 VKVTVNYPPTITESK--------SNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+ VT++ PPT + + + E G+ + S +P P +W +D ++
Sbjct: 31780 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGP 31839
Query: 263 GLEIKSTEGQS--SLTVTNVTEEHYGNYTCVAANKLGVTN 300
+EI EG +L + + E G Y A N G T+
Sbjct: 31840 NIEI-IHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTS 31878
Score = 50.4 bits (119), Expect = 2e-06
Identities = 50/202 (24%), Positives = 81/202 (40%), Gaps = 19/202 (9%)
Query: 112 SVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTLVCMANGRPEPVITWRHL 168
++ EP L VPP+I + S +TV G+NV L G+P P ++W+
Sbjct: 19273 NISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 19332
Query: 169 TPTGREFEGEEE-------YLEILGITREQSGKYECKAANE--VSSADVKQVKVTVNYPP 219
+ EG + LE+ + R+ SG Y A N SA +K + PP
Sbjct: 19333 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPP 19392
Query: 220 T---ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLT 276
I + S+ A + L+ S + + D + N ++ +T +S +
Sbjct: 19393 ASVKINKMYSDRAMLSWEPPLEDGGSEIT----NYIVDKRETSRPNWAQVSATVPITSCS 19448
Query: 277 VTNVTEEHYGNYTCVAANKLGV 298
V + E H + A NK GV
Sbjct: 19449 VEKLIEGHEYQFRICAENKYGV 19470
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 11/105 (10%)
Query: 112 SVQTQHEPKTSQVYL--IVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWR--- 166
S TQ E TS++ I +PPKI + SD++++EG +T+ C G P P +TW
Sbjct: 33307 SNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGG 33366
Query: 167 ---HLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
H GR E + L I+ + ++ G Y NE S
Sbjct: 33367 RKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Score = 49.7 bits (117), Expect = 4e-06
Identities = 59/287 (20%), Positives = 106/287 (36%), Gaps = 40/287 (13%)
Query: 40 NITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQ 99
++ V + D A C V + WL G + + D R EL K ++S+ I+
Sbjct: 11848 DVKVFEKDEAKFECEVSREPKTFRWLK-------GTQEITGDDRFELIK-DGTKHSMVIK 11899
Query: 100 KVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRP 159
DE Y + +H TS +I + K DVT E +
Sbjct: 11900 SAAFEDEAKYMFEAEDKH---TSGKLIIEGIRLKFLTPLKDVTAKEKESAVFT------- 11949
Query: 160 EPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVT---VN 216
+ H + F+ ++ ++ + GK ++S D Q++V ++
Sbjct: 11950 ---VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMS 12006
Query: 217 YPPTITESKSNEATTGR----------QASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
+T + + TG+ + L+CE S AP +W++D I + I
Sbjct: 12007 SEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVI 12065
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTC-----VAANKLGVTNASLVLFRP 308
K+ + L + + G YTC + KL + + + L RP
Sbjct: 12066 KADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRP 12112
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/250 (23%), Positives = 103/250 (41%), Gaps = 34/250 (13%)
Query: 18 RLLC---LLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIF-A 73
RL+C + L V + R ++T+++G T + C N K W I+
Sbjct: 8728 RLVCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQ 8787
Query: 74 GHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK 133
G K ++ +V + L I V D+G YTC + + +TS I P +
Sbjct: 8788 GRHKTEVEHKV---------HKLTIADVRAEDQGQYTCKYE---DLETSAELRIEAEPIQ 8835
Query: 134 ISNISSDVTVNEGSNVTLVCMANGRPEPVITW----RHLTPTGR---EFEGEEEYLEILG 186
+ ++ V+E + T C + + ++TW LT + + +G Y+ I
Sbjct: 8836 FTKRIQNIVVSEHQSATFECEVS-FDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHN 8894
Query: 187 ITREQSGKYECKAANEV-----SSADV----KQVKVTVNYPPTITESKSNEATTGRQASL 237
+T + G Y A E S+A++ K++K+ + PP I +S+ T +A
Sbjct: 8895 VTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELK-PPDIPDSRVPIPTMPIRAVP 8953
Query: 238 KCEASAVPAP 247
E V AP
Sbjct: 8954 PEEIPPVVAP 8963
Score = 47.4 bits (111), Expect = 2e-05
Identities = 47/204 (23%), Positives = 78/204 (38%), Gaps = 42/204 (20%)
Query: 28 PVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVEL 86
P + F++ +TV +G+ L C V+ ++ WL AG + ++
Sbjct: 8342 PKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLK------AGRE-------IKP 8388
Query: 87 EKRHSLEYS-----LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDV 141
R S ++ L ++ V D G Y C T++ + ++ P ++ +
Sbjct: 8389 SDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKA 8448
Query: 142 TVN---------------EGSNVTLVCMANGRPEPVITW-----RHLTPTGREF---EGE 178
V+ E + T + G P P + W R L GR F +G+
Sbjct: 8449 AVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGD 8508
Query: 179 EEYLEILGITREQSGKYECKAANE 202
E LEI T+ SG Y C A NE
Sbjct: 8509 EAKLEIRDTTKTDSGLYRCVAFNE 8532
Score = 47.4 bits (111), Expect = 2e-05
Identities = 57/268 (21%), Positives = 102/268 (38%), Gaps = 23/268 (8%)
Query: 30 RSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKR 89
R + R ++TV G+TA C + ++ V W + L+P ++ R
Sbjct: 12194 RVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGK---------KLEPSDKVVPR 12244
Query: 90 -HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSN 148
++L ++ V + D G T + KT + + P + + D TV EG+
Sbjct: 12245 SEGKVHTLTLRDVKLEDAGEVQL---TAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGAT 12301
Query: 149 VTLVCMANGRPEPVITWRHLTP--TGREFE----GEEEYLEILGITREQSGKYECKAANE 202
L C + V +++ T +++E G L I T E Y C A +
Sbjct: 12302 AVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF 12361
Query: 203 VSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSAN 262
+S ++ V V + +T+ + E A +CE S A +W++D I
Sbjct: 12362 KTSCNLNVVPPHVEFLRPLTDLQVREK---EMARFECELSRENA-KVKWFKDGAEIKKGK 12417
Query: 263 GLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
+I S L + + Y+C
Sbjct: 12418 KYDIISKGAVRILVINKCLLDDEAEYSC 12445
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 188 TREQSGKYECKAANEVSSADVKQVKV----------TVNYPPTITESKSNEATTGRQASL 237
TRE YE A+ E+ SA +++ + T +T+ +S G A
Sbjct: 32521 TRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARF 32580
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
C+ P P W R ++++ ++ +T+ +S+ +++V GNY+ V N G
Sbjct: 32581 SCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEG 32640
Query: 298 VTNASLVL 305
A L
Sbjct: 32641 KQEAEFTL 32648
Score = 46.2 bits (108), Expect = 4e-05
Identities = 74/309 (23%), Positives = 119/309 (38%), Gaps = 28/309 (9%)
Query: 24 PTGLPVRSVDFNRGTD---NITVRQGDTAILRCVVEDKN-SKVAW--LNRSGIIFAGHDK 77
P G PV ++ + N + G + ++ +E K + + W LN++ I
Sbjct: 22343 PPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKT 22402
Query: 78 WSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI 137
L+ VE E R S E + I K E C V + I+ ++
Sbjct: 22403 TGLEEGVEYEFRVSAENIVGIGKPSKVSE----CYVARDPCDPPGRPEAIIVTRNSVTLQ 22458
Query: 138 SSDVTVNEGSNVT-LVCMANGRPEP---VITWRHLTPTGREFEG--EEEYLEILGITREQ 191
T + GS +T + PE ++ ++ T E G E+ E I R
Sbjct: 22459 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 22518
Query: 192 SGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEAT----TGRQASLKCEASAVPAP 247
+G + +E + A + +V PP I+ + T G + + P P
Sbjct: 22519 AGVFS--EPSESTGAITARDEVD---PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP 22573
Query: 248 DFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG---VTNASLV 304
+W + D +++ LEIKST+ +SL+V + GNY A N G VT V
Sbjct: 22574 TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 22633
Query: 305 LFRPGSVRG 313
L RPG G
Sbjct: 22634 LDRPGPPEG 22642
Score = 46.2 bits (108), Expect = 4e-05
Identities = 57/269 (21%), Positives = 106/269 (39%), Gaps = 38/269 (14%)
Query: 40 NITVRQGDTAILRCVVEDKN-SKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
++TV +G++A C + + V WL + ++ S +V K S + I
Sbjct: 32569 SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLST-----SARHQVTTTKYKS---TFEI 32620
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
V DEG+Y+ V+ + ++ L +Q + VT ++ V
Sbjct: 32621 SSVQASDEGNYSVVVENSEGKQEAEFTLTIQ--------KARVTEKAVTSPPRV----KS 32668
Query: 159 PEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK-VTVNY 217
PEP + + + + E + + E ++V+ + V+
Sbjct: 32669 PEPRVKSPEAVKSPKRVKSPEP------------SHPKAVSPTETKPTPTEKVQHLPVSA 32716
Query: 218 PPTITESKSNEATTGRQASLKC--EASAVPAPDFEWYRDDTRINSANGLEIK-STEGQSS 274
PP IT+ EA+ A L C E+S + A + WY+D ++ + S +G
Sbjct: 32717 PPKITQFLKAEASK-EIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYE 32775
Query: 275 LTVTNVTEEHYGNYTCVAANKLGVTNASL 303
L + N+TE G Y C + + G + +L
Sbjct: 32776 LKINNLTESDQGEYVCEISGEGGTSKTNL 32804
Score = 45.8 bits (107), Expect = 5e-05
Identities = 34/141 (24%), Positives = 59/141 (41%), Gaps = 9/141 (6%)
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTV-----NYPPTIT-ESKSNEATTGRQASLKC 239
G+ ++ +A N + ++ ++ V + PTI E+ G + S+
Sbjct: 14349 GVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPV 14408
Query: 240 EASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVT 299
AVP P W++D + +++ L +K+ + L V G YT NKLG
Sbjct: 14409 PFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 14468
Query: 300 NASL---VLFRPGSVRGINGS 317
AS+ V+ PG + I S
Sbjct: 14469 TASINVKVIGLPGPCKDIKAS 14489
Score = 45.8 bits (107), Expect = 5e-05
Identities = 27/86 (31%), Positives = 36/86 (41%), Gaps = 3/86 (3%)
Query: 231 TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
+G +K P P W++D I +EI G +SL V + T +H G YT
Sbjct: 27972 SGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 28031
Query: 291 VAANKLGVTNASL---VLFRPGSVRG 313
A N G A + V PG V G
Sbjct: 28032 EAKNASGSAKAEIKVKVQDTPGKVVG 28057
Score = 45.8 bits (107), Expect = 5e-05
Identities = 48/195 (24%), Positives = 68/195 (34%), Gaps = 45/195 (23%)
Query: 145 EGSNVTLVC-MANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSG 193
EG +V VC + N +TW R+ E E+Y L + IT+ G
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGV---RQLENSEKYEITYEDGVAILYVKDITKLDDG 31637
Query: 194 KYECKAANEVSSAD------VKQVKVTVNY---------------------PPTITESKS 226
Y CK N+ VK V+ +Y PP T
Sbjct: 31638 TYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLY 31697
Query: 227 NE-ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG---LEIKSTEGQSSLTVTNVTE 282
N+ A G + P P WY+ +I + +S +G LT+ +VT
Sbjct: 31698 NKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTT 31757
Query: 283 EHYGNYTCVAANKLG 297
+ YT VA NK G
Sbjct: 31758 DDDAEYTVVARNKYG 31772
Score = 44.7 bits (104), Expect = 1e-04
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 15/126 (11%)
Query: 187 ITREQSGKYECKAANEVSSADVK-QVKVTVN---YPPTITESKSNEATT-----GRQASL 237
+ Q ++ KA NE+ ++ + V + PPTI S T G +
Sbjct: 15359 LDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHI 15418
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGL------EIKSTEGQSSLTVTNVTEEHYGNYTCV 291
+ + +P P EW +++T I E+ +E ++ L++ E G YT
Sbjct: 15419 PADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVT 15478
Query: 292 AANKLG 297
A+N+LG
Sbjct: 15479 ASNRLG 15484
Score = 44.3 bits (103), Expect = 2e-04
Identities = 35/139 (25%), Positives = 56/139 (40%), Gaps = 9/139 (6%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQVKVTVNYP----PTITESKSNEATTGRQASLKC 239
I G+ + + + A NE +D +Q+ V V P + N T LK
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 240 EASAV--PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ + P P W++D+ + + +STE S LT+ + E G+Y N G
Sbjct: 22168 DVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
Query: 298 VTNASL---VLFRPGSVRG 313
+L VL +PG G
Sbjct: 22228 EAIETLNVIVLDKPGPPTG 22246
Score = 43.9 bits (102), Expect = 2e-04
Identities = 43/186 (23%), Positives = 79/186 (42%), Gaps = 13/186 (6%)
Query: 128 VQVPPKISNIS---SDVTVNEGSNVTLVCMANGRPEPV---ITWRHLTPTGR---EFEGE 178
++V P++ + DVTV G T C + PV + + L P+ + EG+
Sbjct: 12189 LRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGK 12248
Query: 179 EEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLK 238
L + + E +G+ + A + + A++ + V + + + E T A L+
Sbjct: 12249 VHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGAT---AVLE 12305
Query: 239 CEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
CE S A +W+++ T I + EI + L + + T E YTC A +
Sbjct: 12306 CEVSRENAK-VKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTS 12364
Query: 299 TNASLV 304
N ++V
Sbjct: 12365 CNLNVV 12370
Score = 43.9 bits (102), Expect = 2e-04
Identities = 38/155 (24%), Positives = 58/155 (37%), Gaps = 16/155 (10%)
Query: 178 EEEYLEILGITREQSGKYECKAANEVSSADVKQ-------VKVTVNYPPTITESKSNEAT 230
+E Y E+ +T +Q ++ A N S VK V P + + K +
Sbjct: 25740 QETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVI 25799
Query: 231 T---GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGN 287
G + + + P P W +D I EI ST+ + LTV + G
Sbjct: 25800 VVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQ 25859
Query: 288 YTCVAANKLGVTNASL---VLFRPGSVRG---ING 316
Y N G + ++ VL +PG G ING
Sbjct: 25860 YVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEING 25894
Score = 43.5 bits (101), Expect = 3e-04
Identities = 59/270 (21%), Positives = 94/270 (34%), Gaps = 30/270 (11%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDK----WSLDPRVELEKRHSLEYSLR 97
TV QG A R V K ++G+ D+ W D EL
Sbjct: 2088 TVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV---------- 2137
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTLVCM 154
I+ V D S +S +L+VQ I+ + V + + T C
Sbjct: 2138 IRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECE 2197
Query: 155 ANGRPEPVITWRHLTPTGREFEGEE---------EYLEILGITREQSGKYECKAANEVSS 205
+ EP + + EG++ +L IL I + Y C + +
Sbjct: 2198 TS---EPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV 2254
Query: 206 ADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLE 265
++ V + E + E L+C S + +WY +D + S
Sbjct: 2255 KTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENI-EGKWYHNDVELKSNGKYT 2313
Query: 266 IKSTEGQSSLTVTNVTEEHYGNYTCVAANK 295
I S G+ +LTV +VT+E G Y+ V K
Sbjct: 2314 ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2343
Score = 43.1 bits (100), Expect = 4e-04
Identities = 63/292 (21%), Positives = 125/292 (42%), Gaps = 28/292 (9%)
Query: 32 VDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHS 91
V+F + +I V + + L C+V +N + W + + + K+++ R +
Sbjct: 2267 VEFVKELQDIEVPESYSGELECIVSPENIEGKWYHND-VELKSNGKYTITSRRGRQ---- 2321
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
+L ++ V D+G Y+ + + KT+ + P I SD V EG V L
Sbjct: 2322 ---NLTVKDVTKEDQGEYSFVIDGK---KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQL 2375
Query: 152 ---VCMANGRPEPVITWRHLTPTGRE---FEGEEEYLEILGITREQSGKYECKA-ANEVS 204
V + + + + + P+ R + + L I +T+E +G Y A +S
Sbjct: 2376 EVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLS 2435
Query: 205 SADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
++ +V+V IT K G +A L+C+ S +WY +D +I + +
Sbjct: 2436 TSG----RVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRV 2491
Query: 265 E--IKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGI 314
+ +K T+ + + T+ ++E G Y + TN +L + + +RG+
Sbjct: 2492 QAIVKGTKQRLVINRTHASDE--GPYKLIVGRV--ETNCNLSVEKIKIIRGL 2539
Score = 42.7 bits (99), Expect = 5e-04
Identities = 39/172 (22%), Positives = 67/172 (38%), Gaps = 23/172 (13%)
Query: 145 EGSNVTLVCMANGRPEPVITWRHLTPTGREF-----------EGEEEYLEILGITREQSG 193
EG GRP P W H G++ E + L I+ T SG
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFH---DGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSG 1526
Query: 194 KYECKAANEVSSADVKQVKVTVNY------PPTITESKSNEATTGRQASLKCEASAVPAP 247
++ A N + + + +TV P + + K+ G + +K A+ P P
Sbjct: 1527 EWTVVAQNRAGRSSISVI-LTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNP 1585
Query: 248 DFEWYRDDTRI--NSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
D W ++ I + + I+ T+G+++L + + + YT A NK G
Sbjct: 1586 DIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAG 1637
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 14/124 (11%)
Query: 46 GDTAILRCVVEDKNSKVAWL-NRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVY 104
G +AI C+V + W+ + S I + ++ D + + L I V +
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGK---------DRKLHIIDVQLS 11183
Query: 105 DEGSYTCSVQTQHEPKTSQVYLIVQVPPK--ISNISSDVTVNEGSNVTLVCMANGRPEPV 162
D G YTC ++ ++ KTS L+V+ P + + +VTV +G + L C N E
Sbjct: 11184 DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERD 11241
Query: 163 ITWR 166
+ WR
Sbjct: 11242 VVWR 11245
Score = 42.4 bits (98), Expect = 6e-04
Identities = 45/191 (23%), Positives = 73/191 (38%), Gaps = 23/191 (12%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY---------- 181
PKI TV +GS+ G+P+P W G + E +
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK---NGVKIERSDRIYWYWPEDNVC 2134
Query: 182 -LEILGITREQSGKYECKAAN---EVSSAD--VKQVKVTVNYPPTITESKSNEATTGRQA 235
L I +T E S KA N E SS + Q K + + + + + E T A
Sbjct: 2135 ELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT--MA 2192
Query: 236 SLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANK 295
+ +CE S P +WY+D ++ + + S L++ + +Y+CV
Sbjct: 2193 TFECETSE-PFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVED 2251
Query: 296 LGV-TNASLVL 305
V T A L++
Sbjct: 2252 ENVKTTAKLIV 2262
Score = 42.4 bits (98), Expect = 6e-04
Identities = 56/261 (21%), Positives = 93/261 (35%), Gaps = 30/261 (11%)
Query: 43 VRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVD 102
V++ + C V + +K W IF D + + L Y+LRI+
Sbjct: 12651 VKEQQEVVFNCEVNTEGAKAKWFRNEEAIF--------DSSKYIILQKDLVYTLRIRDAH 12702
Query: 103 VYDEGSYTCSVQTQH--EPKTSQVYLIVQVPP-KISNISSDVTVNEGSNVTLVCMANGRP 159
+ D+ +Y S+ T H E S LIV+ +I D+ E +VT C N R
Sbjct: 12703 LDDQANYNVSL-TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVN-RL 12760
Query: 160 EPVITWRHLTPTGRE--FEGEEEY--------LEILGITREQSGKYECKAANEVSSADVK 209
+ W T G E F+ Y L I G+Y A + S A++
Sbjct: 12761 NVTLKW---TKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELL 12817
Query: 210 QVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
++ + + + T A C+ S A + +WYR+ I + +
Sbjct: 12818 IIEAPTEF---VEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKFEKD 12873
Query: 270 EGQSSLTVTNVTEEHYGNYTC 290
L + + + Y C
Sbjct: 12874 GSIHRLIIKDCRLDDECEYAC 12894
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/134 (25%), Positives = 57/134 (42%), Gaps = 14/134 (10%)
Query: 190 EQSGKYECKA----ANEVSSADVKQVKVTV---NYPPTITESKSNEAT----TGRQASLK 238
E+ +Y+ +A A +S VT+ N PP I S + ++ G L
Sbjct: 19257 EEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLD 19316
Query: 239 CEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
P P W +D T + A G+++ +L + +V + G+YT A N G
Sbjct: 19317 ATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGS 19376
Query: 299 TNASL---VLFRPG 309
+A++ VL +PG
Sbjct: 19377 KSATIKLKVLDKPG 19390
Score = 42.0 bits (97), Expect = 8e-04
Identities = 30/110 (27%), Positives = 43/110 (39%), Gaps = 9/110 (8%)
Query: 207 DVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266
+ ++KV V + T+ G L+ + S P P EW +D + LEI
Sbjct: 21457 EAPKIKVDVKFKDTVI------LKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEI 21510
Query: 267 KSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL---VLFRPGSVRG 313
K + ++L + T G YT A N G VL RPG G
Sbjct: 21511 KIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEG 21560
Score = 42.0 bits (97), Expect = 8e-04
Identities = 28/135 (20%), Positives = 52/135 (38%), Gaps = 9/135 (6%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQVKVTVN------YPPTITESKSNEATTGRQASL 237
+ G++ Q ++ KA NE +D + + V V P + G +
Sbjct: 24272 VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKI 24331
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ P P+ W +D + + ++ T + L + ++ +G YT A N G
Sbjct: 24332 EIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAG 24391
Query: 298 VTNASL---VLFRPG 309
+L VL +PG
Sbjct: 24392 TATENLSVIVLEKPG 24406
Score = 41.6 bits (96), Expect = 0.001
Identities = 56/282 (19%), Positives = 109/282 (38%), Gaps = 19/282 (6%)
Query: 30 RSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKR 89
R ++F + +I V + A+ C V + + V W+ + + R++++K
Sbjct: 3056 RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDD-------QELQITDRIKIQKE 3108
Query: 90 HSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
+ + L I + D G YT V T+++++ + +I +I +V V E
Sbjct: 3109 KYV-HRLLIPSTRMSDAGKYT--VVAGGNVSTAKLFVEGR-DVRIRSIKKEVQVIEKQRA 3164
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANE---VSSA 206
+ N ++ + + +Y+ I R + A E V+
Sbjct: 3165 VVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR 3224
Query: 207 DVKQVKVTVNYPP---TITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
+ V + VN P + E + +G+ A S P P WY+++ +++
Sbjct: 3225 NRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFK 3284
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV--TNASL 303
+ + +L + E YTC A N GV T+ASL
Sbjct: 3285 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326
Score = 41.2 bits (95), Expect = 0.001
Identities = 34/145 (23%), Positives = 59/145 (40%), Gaps = 17/145 (11%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQVKV------------TVNYPPTITESKSNEATT 231
I G+T+ ++ A N V S V ++ P TE A
Sbjct: 26829 ISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRA-- 26886
Query: 232 GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCV 291
G L+ S PAP EWY+DD + + + +++T +S+ + + + G Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELK 26946
Query: 292 AANKLGVTNASL---VLFRPGSVRG 313
N +G +A++ +L +PG G
Sbjct: 26947 LRNAMGSASATIRVQILDKPGPPGG 26971
Score = 41.2 bits (95), Expect = 0.001
Identities = 53/280 (18%), Positives = 113/280 (40%), Gaps = 27/280 (9%)
Query: 43 VRQGDTAILRCVVEDKNS-KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
+ +G + C + + S ++ W + I S+ V + + ++ YSL I+
Sbjct: 33145 INEGQNVLFTCEISGEPSPEIEWFKNNLPI-------SISSNVSISRSRNV-YSLEIRNA 33196
Query: 102 DVYDEGSYTCSVQT---QHEPKTSQVYL-IVQVPPK--ISNISSDVTVNEGSNVTLVCMA 155
V D G YT + Q S + L +V+ P + + S D ++ + V M+
Sbjct: 33197 SVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMS 33256
Query: 156 NGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAAN--------EVSSAD 207
+ E + + E + + ++ Q E +++ ++ S+
Sbjct: 33257 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 33316
Query: 208 VKQVKVTV-NYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYRDDTRINS--ANG 263
K +K + PP I S+ G+ ++ C + P P+ W +I+S
Sbjct: 33317 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR 33376
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
I++T+ ++L + +V ++ G YT N+ G +A++
Sbjct: 33377 FHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATV 33416
Score = 40.8 bits (94), Expect = 0.002
Identities = 46/240 (19%), Positives = 80/240 (33%), Gaps = 48/240 (20%)
Query: 114 QTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW----RHLT 169
+T+ P +L V PPKI+ E + +T V ++ +TW + L
Sbjct: 32700 ETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLK 32759
Query: 170 PTGR---EFEGEEEY-LEILGITREQSGKYECKAA------------------------- 200
G + + Y L+I +T G+Y C+ +
Sbjct: 32760 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVS 32819
Query: 201 --NEVSSADVKQVKVTV-------------NYPPTITESKSNEATTGRQASLKCEASAVP 245
+E +D K + TV + P +T + ++ A +A+ P
Sbjct: 32820 KISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEP 32879
Query: 246 APDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
P W +D I ++ +G L + G YTC N G ++S L
Sbjct: 32880 RPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 32939
Score = 40.4 bits (93), Expect = 0.002
Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 26/262 (9%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
T + D L+C V K+ V W + G K+S+ K L L+I+K
Sbjct: 11673 TAVEKDEITLKCEVS-KDVPVKWF-KDGEEIVPSPKYSI-------KADGLRRILKIKKA 11723
Query: 102 DVYDEGSYTCSVQTQHEPKTSQVYL-IVQVPPKISNISSDVTVNEGSNVTLVCMANGRPE 160
D+ D+G Y C T V +++V + + +V V E ++ + P+
Sbjct: 11724 DLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGV--EVFVGETAHFEIEL---SEPD 11778
Query: 161 PVITWR------HLTPTGREFEGEEEYLEIL-GITREQSGKYECKAANEVSSADVKQVKV 213
W+ +P E ++++ IL +G+ +AAN S+A++K ++
Sbjct: 11779 VHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKEL 11838
Query: 214 TVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
+ + +++ K E +A +CE S P F W + I + E+ +
Sbjct: 11839 PLIFITPLSDVKVFEKD---EAKFECEVSREP-KTFRWLKGTQEITGDDRFELIKDGTKH 11894
Query: 274 SLTVTNVTEEHYGNYTCVAANK 295
S+ + + E Y A +K
Sbjct: 11895 SMVIKSAAFEDEAKYMFEAEDK 11916
Score = 40.4 bits (93), Expect = 0.002
Identities = 36/148 (24%), Positives = 55/148 (37%), Gaps = 13/148 (8%)
Query: 179 EEYLEILGITREQSGKYECKAANEVSSADVKQ-------VKVTVNYPPTITESKSNEA-- 229
E + G+T +Q ++ A N + K V P + K +
Sbjct: 23577 ETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIV 23636
Query: 230 -TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNY 288
G L+ + P P EW R D I + EIK+T+ ++ L V + G Y
Sbjct: 23637 VNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQY 23696
Query: 289 TCVAANKLGVTNASL---VLFRPGSVRG 313
A+N G + + VL RPG G
Sbjct: 23697 ILRASNVAGSKSFPVNVKVLDRPGPPEG 23724
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/115 (22%), Positives = 44/115 (38%), Gaps = 17/115 (14%)
Query: 202 EVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
EV +D+ +VTV G L+ P P W +D + +
Sbjct: 27562 EVDLSDIPGAQVTVRI--------------GHNVHLELPYKGKPKPSISWLKDGLPLKES 27607
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAAN---KLGVTNASLVLFRPGSVRG 313
+ TE + +L++ N +EH G YT + N ++ V + L P +G
Sbjct: 27608 EFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 27662
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 3/113 (2%)
Query: 204 SSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANG 263
SS +K+ ++ T ++ G ++ S PAP W ++ R+ +
Sbjct: 28634 SSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDR 28693
Query: 264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS---LVLFRPGSVRG 313
+ I +T+ +++LTV + G Y N GV S +V+ RPG V G
Sbjct: 28694 VSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTG 28746
Score = 40.0 bits (92), Expect = 0.003
Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 13/117 (11%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPK--ISNISSDVTVNEGSNVT 150
+YS R+ V+V Y+ S+ + EP +++P ++ VT+ G+++
Sbjct: 29412 KYSFRVAAVNVKGMSEYSESI-AEIEPVER-----IEIPDLELADDLKKTVTIRAGASLR 29465
Query: 151 LVCMANGRPEPVITW--RHLTPTGREFEGEEEYLEIL---GITREQSGKYECKAANE 202
L+ +GRP PVITW + + R E +L + R +GKY +A N+
Sbjct: 29466 LMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQ 29522
Score = 40.0 bits (92), Expect = 0.003
Identities = 30/141 (21%), Positives = 57/141 (40%), Gaps = 7/141 (4%)
Query: 176 EGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQA 235
EGE+ I R Q+ K + V++ V+ ++V + K+ GR
Sbjct: 29701 EGEQYLFRI----RAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPV 29756
Query: 236 SLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANK 295
L + P P W+ +++ + + +++ + LT+ T G YT N
Sbjct: 29757 ELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNV 29816
Query: 296 LGVTNAS---LVLFRPGSVRG 313
G T+ + ++L +PG G
Sbjct: 29817 TGTTSETIKVIILDKPGPPTG 29837
Score = 39.7 bits (91), Expect = 0.004
Identities = 44/186 (23%), Positives = 71/186 (38%), Gaps = 28/186 (15%)
Query: 131 PPKI---SNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE------Y 181
PP+I +++ V V G + L + GRP P +TWR + +G+ + +
Sbjct: 18603 PPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF 18662
Query: 182 LEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEA 241
L I TR+ SGKY N V ++ P +++ K ++ T C
Sbjct: 18663 LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVT-----KTSCHV 18717
Query: 242 SAVPAPD----------FEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCV 291
S P + E D + S E+K T S VTN+ + +
Sbjct: 18718 SWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKT----SFHVTNLVPGNEYYFRVT 18773
Query: 292 AANKLG 297
A N+ G
Sbjct: 18774 AVNEYG 18779
Score = 39.7 bits (91), Expect = 0.004
Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 11/133 (8%)
Query: 183 EILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEAS 242
E+ G+ + ++ A N++ +D V +YP I E + +L A
Sbjct: 19650 EVTGLMEDTQYQFRVYAVNKIGYSDPSDVP-DKHYPKDILIPPEGELDADLRKTLILRAG 19708
Query: 243 AV----------PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVA 292
P P W + + + GL+IKST+ + L NV + G Y
Sbjct: 19709 VTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTL 19768
Query: 293 ANKLGVTNASLVL 305
N G ++V+
Sbjct: 19769 ENSCGKKEYTIVV 19781
Score = 38.9 bits (89), Expect = 0.007
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 1/74 (1%)
Query: 225 KSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK-STEGQSSLTVTNVTEE 283
K+ G + C+ S P P WY+D RI ++ +G++SL + V E
Sbjct: 1298 KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPE 1357
Query: 284 HYGNYTCVAANKLG 297
G YT A+N G
Sbjct: 1358 DEGIYTAFASNIKG 1371
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/184 (21%), Positives = 73/184 (39%), Gaps = 21/184 (11%)
Query: 97 RIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMAN 156
+I + D+ + +V + EPK + + P I D TV+ S A
Sbjct: 32820 KISETKKSDQKTTESTVTRKTEPKAPEP---ISSKPVIVTGLQDTTVSSDSVAKFAVKAT 32876
Query: 157 GRPEPVITW----RHLTPTGREFEGEEE---YLEILGITREQSGKYECKAANEVSSADVK 209
G P P W + +T G+ E++ +LEI SG Y C N S
Sbjct: 32877 GEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVS-S 32935
Query: 210 QVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
K+T+ I ++++ + +T + + + + AV +++ + EIK +
Sbjct: 32936 SCKLTIK---AIKDTEAQKVSTQKTSEITPQKKAV-------VQEEISQKALRSEEIKMS 32985
Query: 270 EGQS 273
E +S
Sbjct: 32986 EAKS 32989
Score = 37.7 bits (86), Expect = 0.015
Identities = 56/277 (20%), Positives = 102/277 (36%), Gaps = 35/277 (12%)
Query: 27 LPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVEL 86
L V +V + ++T + T V V W ++S + DK L ++
Sbjct: 2790 LHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKS-VEIKPSDKHRLVSERKV 2848
Query: 87 EKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEG 146
K L +Q + D G YT +V Q E K + + + NI V E
Sbjct: 2849 HK-------LMLQNISPSDAGEYT-AVVGQLECKAKLFVETLHITKTMKNIE----VPET 2896
Query: 147 SNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYE 196
+ C + P + ++ G E E E++ L I+ + E S +Y
Sbjct: 2897 KTASFECEVSHFNVPSMWLKN----GVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2952
Query: 197 CKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDD 255
N+ QV T+ P + S + + ++ E + ++W ++
Sbjct: 2953 FVCGND-------QVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLKNG 3005
Query: 256 TRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVA 292
I S + ++++ + SL + NV +YT VA
Sbjct: 3006 VEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVA 3042
Score = 37.7 bits (86), Expect = 0.015
Identities = 42/181 (23%), Positives = 71/181 (39%), Gaps = 22/181 (12%)
Query: 40 NITVRQGDTAILRC-VVEDKNSKVAWLN-RSGIIFAGHDKWSLDPRVELEKRHSLEYSLR 97
++T + G+ A L C +V + W +I + K S D R ++L
Sbjct: 30541 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRT---------HTLT 30591
Query: 98 IQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNVTLVCM 154
+ + DEG YTC + + L++Q P+ + GS + L M
Sbjct: 30592 VMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVM 30651
Query: 155 ANGRPEPVITWRH-----LTPTGREFEGEEEYLEIL--GITRE-QSGKYECKAANEVSSA 206
GRP P +TW H E E Y ++ + R+ +GKY+ + +N +
Sbjct: 30652 YIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTV 30711
Query: 207 D 207
D
Sbjct: 30712 D 30712
Score = 37.4 bits (85), Expect = 0.019
Identities = 36/151 (23%), Positives = 53/151 (35%), Gaps = 23/151 (15%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKIS---NISSDVTVNEGSNV 149
EY RI+ ++ EG E S + + PP++ +TV G +
Sbjct: 17874 EYRFRIKAANIVGEGE-------PRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTI 17926
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKA 199
++ GRPEP ITW T G+ E+ L+I R GKY A
Sbjct: 17927 RILARVKGRPEPDITW---TKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISA 17983
Query: 200 ANEVSSADVKQVKVTVNYPPTITESKSNEAT 230
N A + ++ P K T
Sbjct: 17984 KNSSGHAQGSAIVNVLDRPGPCQNLKVTNVT 18014
Score = 37.4 bits (85), Expect = 0.019
Identities = 26/136 (19%), Positives = 54/136 (39%), Gaps = 8/136 (5%)
Query: 182 LEILGITREQSGKYECKAANEVSSADVKQVKVTVN-----YPPTITESKSNEATTGRQAS 236
L + G+ + K+ A N V + ++ + PP I + G++
Sbjct: 18858 LVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLR 18917
Query: 237 LKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKL 296
++ P P +W + + + +++ L + + S L + +VT + G Y+ A N
Sbjct: 18918 IEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 18977
Query: 297 GVTNASL---VLFRPG 309
G + V+ PG
Sbjct: 18978 GTDTQKIKVVVMDAPG 18993
Score = 37.4 bits (85), Expect = 0.019
Identities = 20/76 (26%), Positives = 30/76 (39%)
Query: 229 ATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNY 288
A G + P P W +D+ + S I++T+ S LT+ VT G Y
Sbjct: 27283 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 27342
Query: 289 TCVAANKLGVTNASLV 304
N +G +S V
Sbjct: 27343 ILTIENGVGEPKSSTV 27358
Score = 36.6 bits (83), Expect = 0.033
Identities = 27/140 (19%), Positives = 54/140 (38%), Gaps = 6/140 (4%)
Query: 159 PEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYP 218
P PV + R L+ FE + +I + + +E + Q T+++
Sbjct: 32319 PSPVSSERSLS----RFERSARF-DIFSRYESMKAALKTQKTSERKYEVLSQQPFTLDHA 32373
Query: 219 PTIT-ESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTV 277
P IT +S+ G+ + P + +WY + + ++ + +T G +L +
Sbjct: 32374 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 32433
Query: 278 TNVTEEHYGNYTCVAANKLG 297
+ + G Y V N G
Sbjct: 32434 LDCHTDDSGTYRAVCTNYKG 32453
Score = 36.2 bits (82), Expect = 0.043
Identities = 46/187 (24%), Positives = 65/187 (34%), Gaps = 23/187 (12%)
Query: 34 FNRGTDNITVRQGDTAILRCVVED-KNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
F + ++ V +G TA + +V+W +I S P V++
Sbjct: 8 FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-----STLPGVQISFSDG- 61
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQV---PPKISNISSDVTVNEGSNV 149
L I V + G Y+ TS L+V+ PP +TV +GS V
Sbjct: 62 RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQV 121
Query: 150 TLVCMANGRPEPVITWRHLTPTGREF----------EGEEEYLEILGITREQSGKYECKA 199
L G P PV+ + G E EG+ L I E SG Y A
Sbjct: 122 RLQVRVTGIPTPVVKFYR---DGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 200 ANEVSSA 206
N V A
Sbjct: 179 TNSVGRA 185
Score = 36.2 bits (82), Expect = 0.043
Identities = 35/146 (23%), Positives = 55/146 (37%), Gaps = 20/146 (13%)
Query: 74 GHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQH---EPKTSQVYLIVQ- 129
G DKW+ V++ + I + +E S+ S Q + +P+ V +I +
Sbjct: 22091 GSDKWATCATVKVTEA-------TITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKD 22143
Query: 130 --VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW-------RHLTPTGREFEGEEE 180
+PP + + TV G ++ + GRP P +TW + T E
Sbjct: 22144 LVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNS 22203
Query: 181 YLEILGITREQSGKYECKAANEVSSA 206
L I RE G Y K N A
Sbjct: 22204 LLTIKDACREDVGHYVVKLTNSAGEA 22229
Score = 36.2 bits (82), Expect = 0.043
Identities = 31/140 (22%), Positives = 53/140 (37%), Gaps = 19/140 (13%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQ-----------VKVTVNYPPTITESKSNEATTG 232
I G+T + + A NE +D +Q +K +V P K+ E
Sbjct: 25355 ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKARE---- 25410
Query: 233 RQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVA 292
Q + P W +D + + + S++ +SL++ ++E G Y
Sbjct: 25411 -QLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCV 25469
Query: 293 ANKLG---VTNASLVLFRPG 309
+N G V +VL RPG
Sbjct: 25470 SNSAGSITVPITIIVLDRPG 25489
Score = 35.8 bits (81), Expect = 0.056
Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 15/100 (15%)
Query: 130 VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWR----------HLTPTGREFEGEE 179
+PPKI + +T+ G + + G+P P W+ HL +
Sbjct: 18898 LPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKAD---SS 18953
Query: 180 EYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPP 219
L I +TR+ SG Y A N S D +++KV V P
Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENS-SGTDTQKIKVVVMDAP 18992
Score = 35.8 bits (81), Expect = 0.056
Identities = 23/126 (18%), Positives = 48/126 (38%), Gaps = 6/126 (4%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITES------KSNEATTGRQASL 237
I +T+ + + A NE +D + + V + + E S G+ +
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKI 23249
Query: 238 KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ S P P W +D + + + + ++L++ ++ G Y AN +G
Sbjct: 23250 EVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG 23309
Query: 298 VTNASL 303
AS+
Sbjct: 23310 QKTASI 23315
Score = 35.8 bits (81), Expect = 0.056
Identities = 28/136 (20%), Positives = 52/136 (38%), Gaps = 21/136 (15%)
Query: 184 ILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNE--------------A 229
I G+T + K+ N+V ++D + P I + + E
Sbjct: 26144 ISGLTTGAEYVFRVKSVNKVGASDPSD-----SSDPQIAKEREEEPLFDIDSEMRKTLIV 26198
Query: 230 TTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYT 289
G ++ P P+ W + DT + + + +T+ ++SLT+ N G YT
Sbjct: 26199 KAGASFTMTVPFRGRPVPNVLWSKPDTDLRTR--AYVDTTDSRTSLTIENANRNDSGKYT 26256
Query: 290 CVAANKLGVTNASLVL 305
N L + +LV+
Sbjct: 26257 LTIQNVLSAASLTLVV 26272
Score = 35.0 bits (79), Expect = 0.096
Identities = 47/207 (22%), Positives = 77/207 (37%), Gaps = 29/207 (14%)
Query: 27 LPVRSVDFNRGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVE 85
+P+++ F N+ VR A L C V V W + I A K+
Sbjct: 30923 VPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY------R 30976
Query: 86 LEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP-----PKISNISSD 140
+++ + L I V D Y Q + L V+VP PK
Sbjct: 30977 IQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGA 31036
Query: 141 VTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEIL------------GIT 188
V G V++ +G+P+PVITW+ G++ + +++ G+
Sbjct: 31037 VHALRGEVVSIKIPFSGKPDPVITWQ----KGQDLIDNNGHYQVIVTRSFTSLVFPNGVE 31092
Query: 189 REQSGKYECKAANEVSSADVKQVKVTV 215
R+ +G Y A N D K V++ V
Sbjct: 31093 RKDAGFYVVCAKNRF-GIDQKTVELDV 31118
Score = 34.7 bits (78), Expect = 0.12
Identities = 38/135 (28%), Positives = 50/135 (37%), Gaps = 15/135 (11%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV-----QVPPKISNISSDVTVNEGSNV 149
SL I D G +T Q + + V L V QV P +V + EGS +
Sbjct: 1514 SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573
Query: 150 TLVCMANGRPEPVITW--------RHLTPTGR-EFEGEEEYLEILGITREQSGKYECKAA 200
+ A G P P I W H P R E E L+I + S Y A
Sbjct: 1574 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1633
Query: 201 NEVSSADVKQVKVTV 215
N+ + D + KV V
Sbjct: 1634 NK-AGRDTTRCKVNV 1647
Score = 34.7 bits (78), Expect = 0.12
Identities = 40/189 (21%), Positives = 68/189 (35%), Gaps = 25/189 (13%)
Query: 130 VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEY-------- 181
+PP I ++ + V EG+NV +V G P P +TW P + + Y
Sbjct: 16116 MPPSI-DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLV 16174
Query: 182 ------LEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQA 235
L I R +G Y A N + +A + + P E+ + Q
Sbjct: 16175 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQM 16234
Query: 236 SLKCEASAVPAPD------FEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYT 289
+L S P D + + N + + S + + T+ + E H +
Sbjct: 16235 TL----SWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFR 16290
Query: 290 CVAANKLGV 298
+A NK G+
Sbjct: 16291 IMAQNKYGI 16299
Score = 34.3 bits (77), Expect = 0.16
Identities = 25/86 (29%), Positives = 38/86 (44%), Gaps = 4/86 (4%)
Query: 232 GRQASLKCEASAVPAPDFEWYRDDTRIN-SANGLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
G L+ + P PD W +D + +A +EIKST +++L V + G Y
Sbjct: 24722 GETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYIL 24781
Query: 291 VAANKLGVTNASL---VLFRPGSVRG 313
+N G + + VL RPG G
Sbjct: 24782 KLSNVGGTKSIPITVKVLDRPGPPEG 24807
Score = 33.9 bits (76), Expect = 0.21
Identities = 35/180 (19%), Positives = 68/180 (37%), Gaps = 16/180 (8%)
Query: 32 VDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHS 91
V+ R +I G + + +V WL + ++ G DK + ++ +
Sbjct: 12912 VEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQG-DKHQMMSEGKIHR--- 12967
Query: 92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTL 151
L+I + D+G Y + K ++ L + PKI D+ V+ G +T+
Sbjct: 12968 ----LQICDIKPRDQGEYRFIAKD----KEARAKLELAAAPKIKTADQDLVVDVGKPLTM 13019
Query: 152 VCMANGRPEPVITW----RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
V + P+ W L+ + E+ IL + G+Y+ N+ A+
Sbjct: 13020 VVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAE 13079
Score = 33.9 bits (76), Expect = 0.21
Identities = 46/190 (24%), Positives = 73/190 (38%), Gaps = 13/190 (6%)
Query: 141 VTVNEGSNVTLVCMANGRPEPVITWRH----LTPTGR---EFEGEEEYLEILGITREQSG 193
V G N+ + GRP+P +TW+ L T R E L I R SG
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSG 21134
Query: 194 KYECKAANEVSS-ADVKQVKV-TVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEW 251
Y A N V DV ++V + PPT ++ S + P +
Sbjct: 21135 PYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNY 21194
Query: 252 YRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV----TNASLVLFR 307
+ + +S +E+ +T +++ T +T + A N+ GV T+A +V
Sbjct: 21195 VVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 21254
Query: 308 PGSVRGINGS 317
P V G G+
Sbjct: 21255 PFKVPGPPGT 21264
Score = 33.9 bits (76), Expect = 0.21
Identities = 25/86 (29%), Positives = 34/86 (39%), Gaps = 7/86 (8%)
Query: 137 ISSDVTVNEGSNVTLVCMANGRPEPVITWR----HLTPTGR---EFEGEEEYLEILGITR 189
+ + V G +V ++ GRP P +TWR +L R E L I +TR
Sbjct: 27277 LRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTR 27336
Query: 190 EQSGKYECKAANEVSSADVKQVKVTV 215
+GKY N V V V V
Sbjct: 27337 NDTGKYILTIENGVGEPKSSTVSVKV 27362
Score = 33.1 bits (74), Expect = 0.36
Identities = 33/143 (23%), Positives = 57/143 (39%), Gaps = 15/143 (10%)
Query: 178 EEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNY--PPTITESKSNEATT---- 231
+E Y E+L T+++ + + E A ++ K+T+ P I S S EA
Sbjct: 2024 DESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFER 2083
Query: 232 --------GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQ-SSLTVTNVTE 282
G A + P P+ EWY++ +I ++ + E L + +VT
Sbjct: 2084 IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTA 2143
Query: 283 EHYGNYTCVAANKLGVTNASLVL 305
E + A N G T++ L
Sbjct: 2144 EDSASIMVKAINIAGETSSHAFL 2166
Score = 33.1 bits (74), Expect = 0.36
Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 6/87 (6%)
Query: 245 PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG--VTNAS 302
P P W + I ++ +I ST S LT+ T + G YT A N G V +
Sbjct: 20407 PLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVK 20466
Query: 303 LVLF----RPGSVRGINGSISLAVPLW 325
+ + PG V N S A W
Sbjct: 20467 VTVLDVPGPPGPVEISNVSAEKATLTW 20493
Score = 33.1 bits (74), Expect = 0.36
Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 17/138 (12%)
Query: 187 ITREQSG---KYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASA 243
+T Q+G K+ A N D +V T+ +T + + +Q + ++
Sbjct: 28315 VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGAS 28374
Query: 244 V---------PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAAN 294
+ P P W + D+ ++ +I +T+ S+LTV N G YT N
Sbjct: 28375 IRLFIAYQGRPTPTAVWSKPDSNLSLR--ADIHTTDSFSTLTVENCNRNDAGKYTLTVEN 28432
Query: 295 KLG---VTNASLVLFRPG 309
G +T VL PG
Sbjct: 28433 NSGSKSITFTVKVLDTPG 28450
Score = 32.3 bits (72), Expect = 0.62
Identities = 31/143 (21%), Positives = 52/143 (36%), Gaps = 12/143 (8%)
Query: 179 EEYLEILGITREQSGKYECKAANEVSSADVK------QVKVTVNYPPTITESKSNEATT- 231
E +E+ G+ + Y KA N ++ Q T P + K T
Sbjct: 13643 ETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTV 13702
Query: 232 --GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYT 289
G + L + P P W + D + + I++ +S++T+ + G Y
Sbjct: 13703 KAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI 13762
Query: 290 CVAANKLGVTNASL---VLFRPG 309
A N G A + VL +PG
Sbjct: 13763 IEAVNVCGRATAVVEVNVLDKPG 13785
Score = 32.0 bits (71), Expect = 0.81
Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 2/73 (2%)
Query: 235 ASLKCEASAVPAPDF--EWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVA 292
A +C + + P EW D + +AN L + + G SL G TC A
Sbjct: 1720 AHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRA 1779
Query: 293 ANKLGVTNASLVL 305
NK G + S L
Sbjct: 1780 TNKYGTDHTSATL 1792
Score = 32.0 bits (71), Expect = 0.81
Identities = 20/82 (24%), Positives = 31/82 (37%), Gaps = 2/82 (2%)
Query: 218 PPTITESKSNEAT--TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSL 275
PPT+ ++ T G +L S P P W++D+ + + IK+T +L
Sbjct: 16817 PPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLAL 16876
Query: 276 TVTNVTEEHYGNYTCVAANKLG 297
G Y V N G
Sbjct: 16877 EKIKAKRSDSGKYCVVVENSTG 16898
Score = 32.0 bits (71), Expect = 0.81
Identities = 28/116 (24%), Positives = 42/116 (36%), Gaps = 13/116 (11%)
Query: 141 VTVNEGSNVTLVCMANGRPEPVITWRH-------LTPTGREFEGEEEYLEILGITREQSG 193
VT+ GS++ L G+PEP I W ++ G+ I R SG
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 29116
Query: 194 KYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCE-ASAVPAPD 248
KY N + V + ++ P + T R KC A ++P D
Sbjct: 29117 KYTLTVKNASGTKAVSVMVKVLDSP-----GPCGKLTVSRVTQEKCTLAWSLPQED 29167
Score = 31.6 bits (70), Expect = 1.1
Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 10/111 (9%)
Query: 118 EPKTSQVYLIVQ---VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH----LTP 170
+P++ V ++ + + P + S +V G ++ + +GRP+P ITW L
Sbjct: 23213 DPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ 23272
Query: 171 TGREFEGEEEYLEILGIT---REQSGKYECKAANEVSSADVKQVKVTVNYP 218
T R + L L I ++ G+Y AN V VT++ P
Sbjct: 23273 TTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 31.2 bits (69), Expect = 1.4
Identities = 41/159 (25%), Positives = 61/159 (38%), Gaps = 28/159 (17%)
Query: 89 RHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQV---PPKI---SNISSDVT 142
+ + EY+ RI ++ G EP T ++ Q PP+I +++ V
Sbjct: 25069 KENTEYNFRICAINSEGVG----------EPATLPGSVVAQERIEPPEIELDADLRKVVV 25118
Query: 143 VNEGSNVTLVCMANGRPEPVITWRH----LTPTGR-EFEGEEEYLEILGITREQSGKYEC 197
+ + + L GRPEP + W LT + E L I +TR SG+Y
Sbjct: 25119 LRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNL 25178
Query: 198 KAANEVSSADVKQVKVTVNYPP------TITESKSNEAT 230
N S + V V V P TI E K + T
Sbjct: 25179 TLENN-SGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVT 25216
Score = 31.2 bits (69), Expect = 1.4
Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 14/87 (16%)
Query: 143 VNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEG--EEEYLEILG--------ITREQS 192
+ G ++ + + GRP P +TW G E E E ++LG TR+
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTW---FKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHR 28026
Query: 193 GKYECKAANEVSSADVKQVKVTVNYPP 219
G Y +A N SA ++KV V P
Sbjct: 28027 GVYTVEAKNASGSAKA-EIKVKVQDTP 28052
Score = 31.2 bits (69), Expect = 1.4
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 2/74 (2%)
Query: 232 GRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCV 291
G L S P P W + I+ A+ I +TE S L V V G YT
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQG--IDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIE 29518
Query: 292 AANKLGVTNASLVL 305
A N+ G +A++++
Sbjct: 29519 AENQSGKKSATVLV 29532
Score = 30.8 bits (68), Expect = 1.8
Identities = 24/91 (26%), Positives = 38/91 (41%), Gaps = 4/91 (4%)
Query: 195 YECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRD 254
YE A + K++ T + +KS +A T + + + A P P F +
Sbjct: 830 YEASIAGSAIATLQKELSATSSAQKI---TKSVKAPTVKPSETRVRAEPTPLPQFPFADT 886
Query: 255 DTRINSANGLEIKSTEGQSSLTVTNVTEEHY 285
S G+E+K G S+T T V EE +
Sbjct: 887 PDTYKSEAGVEVKKEVG-VSITGTTVREERF 916
Score = 30.8 bits (68), Expect = 1.8
Identities = 60/262 (22%), Positives = 94/262 (35%), Gaps = 36/262 (13%)
Query: 42 TVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKV 101
TV + A+ C V + +SK WL R G H + + R E + H + K+
Sbjct: 2630 TVAESQEAVFECEVANPDSKGEWL-RDG----KHLPLTNNIRSESD-GHKRRLIIAATKL 2683
Query: 102 DVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEP 161
D D G YT V T KTS + V KI ++TV E +
Sbjct: 2684 D--DIGEYTYKVATS---KTSAKLKVEAV--KIKKTLKNLTVTETQDAVFTVELTHPNVK 2736
Query: 162 VITWRHLTPTGREFEGEEEY----------LEILGITREQSGKYECKAANEVSSA--DVK 209
+ W G E E+Y L I Y + +SA V+
Sbjct: 2737 GVQW---IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVE 2793
Query: 210 QVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKST 269
VK+ + P +T ++ AT + S+ + V +W+ I ++ + S
Sbjct: 2794 TVKI-IKKPKDVTALEN--ATVAFEVSVSHDTVPV-----KWFHKSVEIKPSDKHRLVSE 2845
Query: 270 EGQSSLTVTNVTEEHYGNYTCV 291
L + N++ G YT V
Sbjct: 2846 RKVHKLMLQNISPSDAGEYTAV 2867
Score = 30.8 bits (68), Expect = 1.8
Identities = 42/224 (18%), Positives = 79/224 (35%), Gaps = 37/224 (16%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVP---PKISNISSDVTVNEGSNV 149
EY LR++ V+ EP ++ + P P I + D+ V EG +
Sbjct: 14355 EYVLRVRAVNAIGVS----------EPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKL 14404
Query: 150 TLVCMANGRPEPVITWRHLTPTGREFEGEEE----------YLEILGITREQSGKYECKA 199
++ P P ++W G+E + + +LE+ R +G Y
Sbjct: 14405 SIPVPFRAVPVPTVSWH---KDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITL 14461
Query: 200 ANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVP------APDFEWYR 253
N++ SA + P + K+++ T C+ + P P +
Sbjct: 14462 ENKLGSATASINVKVIGLPGPCKDIKASDITKS-----SCKLTWEPPEFDGGTPILHYVL 14516
Query: 254 DDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ + + S E + S TV ++ + A NK+G
Sbjct: 14517 ERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVG 14560
Score = 30.8 bits (68), Expect = 1.8
Identities = 19/73 (26%), Positives = 29/73 (39%), Gaps = 3/73 (4%)
Query: 244 VPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
VP P +W D + I + +++ S LT+ N G Y +N G ++
Sbjct: 17537 VPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAV 17596
Query: 304 ---VLFRPGSVRG 313
VL PG G
Sbjct: 17597 HLTVLDVPGPPTG 17609
Score = 30.4 bits (67), Expect = 2.4
Identities = 26/97 (26%), Positives = 34/97 (35%), Gaps = 16/97 (16%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITW---RHLTPTGREFEGEEEYLEILGIT 188
P I V V EG C G P+P + W L + F + + L I
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIV 1900
Query: 189 REQSGKYECKAANEVSSADVKQVKVTVNYPPTITESK 225
+CK S D +VKVT P + E K
Sbjct: 1901 -------DCK------SYDTGEVKVTAENPEGVIEHK 1924
Score = 30.4 bits (67), Expect = 2.4
Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 10/54 (18%)
Query: 112 SVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW 165
+V TQ P +++L V+ + + +TV G+ + L G+PEP ITW
Sbjct: 13681 AVDTQEAP---EIFLDVK-------LLAGLTVKAGTKIELPATVTGKPEPKITW 13724
Score = 30.4 bits (67), Expect = 2.4
Identities = 18/80 (22%), Positives = 34/80 (42%), Gaps = 3/80 (3%)
Query: 237 LKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKL 296
LK PAP W + + + + + ++S+ ++L V + + G YT N
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 297 GVTNASL---VLFRPGSVRG 313
G ++ V+ +PG G
Sbjct: 20062 GTKEGTISIKVVGKPGIPTG 20081
Score = 30.4 bits (67), Expect = 2.4
Identities = 35/170 (20%), Positives = 60/170 (35%), Gaps = 6/170 (3%)
Query: 135 SNISSDVTVNEGSNVTLVCMANGRPEPVITWRH-----LTPTGREFEGEEEYLEILGITR 189
S + + V G++ T+ GRP P + W T + L I R
Sbjct: 26190 SEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANR 26249
Query: 190 EQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEAT-TGRQASLKCEASAVPAPD 248
SGKY N +S+A + V ++ P T + T S + AP
Sbjct: 26250 NDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPV 26309
Query: 249 FEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
++ + + + + + + S VTN+ E + N+ GV
Sbjct: 26310 KNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGV 26359
Score = 30.4 bits (67), Expect = 2.4
Identities = 37/151 (24%), Positives = 59/151 (39%), Gaps = 18/151 (11%)
Query: 73 AGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP 132
AGH K L ++ E+ ++ + Y E S EP+ ++
Sbjct: 28595 AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQ-------IEPTA 28647
Query: 133 KISNISSD-VTVNEGSNVTLVCMANGRPEPVITWR----HLTPTGR---EFEGEEEYLEI 184
++ I++ +T GS T+ +GRP P +TW+ L T R + L +
Sbjct: 28648 DLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV 28707
Query: 185 LGITREQSGKYECKAANEVSSADVKQVKVTV 215
R SG+Y N +A VK VTV
Sbjct: 28708 KDSMRGDSGRYFLTLEN---TAGVKTFSVTV 28735
Score = 30.4 bits (67), Expect = 2.4
Identities = 27/106 (25%), Positives = 45/106 (42%), Gaps = 15/106 (14%)
Query: 41 ITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQK 100
+T+R G + L V + V ++ GI A ++ + +SL L + K
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR------AIIDTTESYSL---LIVDK 29506
Query: 101 VDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP------KISNISSD 140
V+ YD G YT + Q K++ V + V P K+ +S D
Sbjct: 29507 VNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRD 29552
Score = 30.0 bits (66), Expect = 3.1
Identities = 31/135 (22%), Positives = 47/135 (34%), Gaps = 31/135 (22%)
Query: 87 EKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV--QVPPKIS---NISSDV 141
E R +Y LR+ V+ EG P +Q + Q PP + ++ +
Sbjct: 15065 EIREGADYKLRVSAVNAAGEGP----------PGETQPVTVAEPQEPPAVELDVSVKGGI 15114
Query: 142 TVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFE-----------GEEEYLEILGITRE 190
+ G + + + GRP P W T E E G + L I R+
Sbjct: 15115 QIMAGKTLRIPAVVTGRPVPTKVW-----TKEEGELDKDRVVIDNVGTKSELIIKDALRK 15169
Query: 191 QSGKYECKAANEVSS 205
G+Y A N S
Sbjct: 15170 DHGRYVITATNSCGS 15184
Score = 30.0 bits (66), Expect = 3.1
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 8/101 (7%)
Query: 126 LIVQVPPKISNI-SSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFE-------G 177
LI+ +S+I + VTV G NV L G+P+P I+W +E E
Sbjct: 27557 LIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTE 27616
Query: 178 EEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYP 218
+ L I +E GKY N V V +T+ P
Sbjct: 27617 NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPP 27657
Score = 30.0 bits (66), Expect = 3.1
Identities = 32/141 (22%), Positives = 51/141 (36%), Gaps = 22/141 (15%)
Query: 87 EKRHSLE-----YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIV---------QVPP 132
+K+++ E Y L I V D+ YT + ++ + + L V + P
Sbjct: 31736 DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRP 31795
Query: 133 KISNISSDVTVNEGSNVTLVCMANGRPEPVITWR------HLTPTGREF-EGEEEY-LEI 184
+ ++ EG +V +G P P + W L P EG + Y L I
Sbjct: 31796 MFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHI 31855
Query: 185 LGITREQSGKYECKAANEVSS 205
E +G Y A N S
Sbjct: 31856 RDTLPEDTGYYRVTATNTAGS 31876
Score = 29.6 bits (65), Expect = 4.0
Identities = 26/100 (26%), Positives = 39/100 (39%), Gaps = 23/100 (23%)
Query: 131 PPKI---SNISSDVTVNEGSNVTLVCMANGRPEPVITWR------------HLTPTGREF 175
PP++ +N++ + + G + L + G P P +TW+ +TP G +
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK- 17273
Query: 176 EGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTV 215
LEI E G Y N S V VKV V
Sbjct: 17274 ------LEIRNAAHEDGGIYSLTVENPAGSKTV-SVKVLV 17306
Score = 29.6 bits (65), Expect = 4.0
Identities = 16/59 (27%), Positives = 27/59 (45%)
Query: 251 WYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPG 309
WY ++ ++ EI +G + L V ++T+ G Y C N G ++ LF G
Sbjct: 31602 WYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKG 31660
Score = 29.3 bits (64), Expect = 5.2
Identities = 29/114 (25%), Positives = 43/114 (37%), Gaps = 17/114 (14%)
Query: 109 YTCSVQTQHEP------KTSQVYLI--VQVPPKISNISSDVTVNEGSNVTLVCMANGRPE 160
Y VQT++E KT +V + +Q P +S +TV G + L G+P
Sbjct: 18171 YEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPF 18230
Query: 161 PVITW------RHLTPTGR---EFEGEEEYLEILGITREQSGKYECKAANEVSS 205
P + W LT + R + + + R GKY A N S
Sbjct: 18231 PEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGS 18284
Score = 29.3 bits (64), Expect = 5.2
Identities = 45/177 (25%), Positives = 68/177 (38%), Gaps = 20/177 (11%)
Query: 135 SNISSDVTVNEGSNVTLVCMANGRPEPVITWR----HLTPTGREFEG-EEEYLEILGITR 189
S + + V G + + GRP P ITW T + +G L I R
Sbjct: 24028 SELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDR 24087
Query: 190 EQSGKYECKAANEVSSADVKQVKVTVNY-----PP---TITESKSNEATTGRQASLKCEA 241
+GKY K N S+ K VTV PP + E + + A + +
Sbjct: 24088 NDAGKYILKLEN---SSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGG 24144
Query: 242 SAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV 298
+ V + R+ TR AN + S ++S V N+TE + +A N+ GV
Sbjct: 24145 AKVKNYVID-KRESTRKAYAN---VSSKCSKTSFKVENLTEGAIYYFRVMAENEFGV 24197
Score = 28.9 bits (63), Expect = 6.8
Identities = 27/141 (19%), Positives = 52/141 (36%), Gaps = 12/141 (8%)
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVN-----YPPTIT-ESKSNEATT---GRQAS 236
G+ ++ KAAN V + +++ +V +PP + + + T G+
Sbjct: 17868 GLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIR 17927
Query: 237 LKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKL 296
+ P PD W ++ + +++ + L + +G Y A N
Sbjct: 17928 ILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSS 17987
Query: 297 GVTNASL---VLFRPGSVRGI 314
G S VL RPG + +
Sbjct: 17988 GHAQGSAIVNVLDRPGPCQNL 18008
Score = 28.9 bits (63), Expect = 6.8
Identities = 20/70 (28%), Positives = 30/70 (42%), Gaps = 5/70 (7%)
Query: 245 PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL- 303
PAP+ W +D+ IN N I++TE + L + G + N G + +
Sbjct: 20804 PAPEVTWTKDN--INLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVN 20861
Query: 304 --VLFRPGSV 311
VL PG V
Sbjct: 20862 VRVLDTPGPV 20871
Score = 28.9 bits (63), Expect = 6.8
Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 15/175 (8%)
Query: 138 SSDVTVNEGSNVTLVCMANGRPEPVITWRH----LTPTGR---EFEGEEEYLEILGITRE 190
S V V GSN+ + +G+P P +T L T R E E + +
Sbjct: 26483 SHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTA 26542
Query: 191 QSGKYECKAANEVSSADVKQVKVTVNYP-----PTITESKSNEATTGRQASLKCEASAVP 245
+G+YE AAN + V ++ P P + + E+ T + K + +
Sbjct: 26543 DAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGS-Q 26601
Query: 246 APDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN 300
++ + +T ++A E+ +T ++ + V +T + A N+ G+++
Sbjct: 26602 VTNYILLKRET--STAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISD 26654
Score = 28.5 bits (62), Expect = 8.9
Identities = 45/183 (24%), Positives = 69/183 (37%), Gaps = 20/183 (10%)
Query: 132 PKIS---NISSDVTVNEGSNVTLVCMANGRPEPVITW----RHLTPTGR-EFEGEE--EY 181
P+IS + VN G L +G+P P I W + + + R E + +
Sbjct: 23623 PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKAL 23682
Query: 182 LEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEA 241
L + R G+Y +A+N S K V V + TG S KC
Sbjct: 23683 LIVKDAIRIDGGQYILRASNVAGS---KSFPVNVKVLDRPGPPEGPVQVTG-VTSEKCSL 23738
Query: 242 SAVP-----APDFEWYRDDTRINSANGLEIKSTE-GQSSLTVTNVTEEHYGNYTCVAANK 295
+ P D Y + R S + ++E +SL VT + E + + +A NK
Sbjct: 23739 TWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNK 23798
Query: 296 LGV 298
GV
Sbjct: 23799 YGV 23801
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 87.0 bits (214), Expect = 2e-17
Identities = 74/278 (26%), Positives = 121/278 (43%), Gaps = 41/278 (14%)
Query: 40 NITVRQGDTAILRCVVED-KNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
+IT+ +G+ +L C E +V W G + G E + + +L+I
Sbjct: 265 SITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGR-----------ETKENYGKTLKI 313
Query: 99 QKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGR 158
+ V D+G+Y C+ T ++IV+ PP+ + + GSN L+C A G
Sbjct: 314 ENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGE 373
Query: 159 PEPVITWR-HLTPT-GREFEGEEEYLEILGITREQ---SGKYECKAANE----VSSADVK 209
P+P I WR + +P F G+ + + T Q + Y+C+A+N +++A++
Sbjct: 374 PQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANID 433
Query: 210 QVKVTVNYPPTITESKSNEAT-TGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKS 268
V V P T+ N AT G A L CE A P W + + E+K
Sbjct: 434 VVDVR---PLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVE---------EVKP 481
Query: 269 TEGQ-------SSLTVTNVTEEHYGNYTCVAANKLGVT 299
EG+ +L + TEE G+Y+C N +G T
Sbjct: 482 LEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKT 519
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/188 (28%), Positives = 82/188 (43%), Gaps = 12/188 (6%)
Query: 130 VPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHL---TPTGREF-EGEEEYLEIL 185
+PP S S +T+ +G + L C A G P P + W + P GRE E + L+I
Sbjct: 255 LPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIE 314
Query: 186 GITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITES-KSNEATTGRQASLKCEASAV 244
++ + G Y C A+N + +A V V PP T+ +S +TG L CEA
Sbjct: 315 NVSYQDKGNYRCTASNFLGTA-THDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGE 373
Query: 245 PAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGV----TN 300
P P +W + + ++ N ++ TN+ H Y C A+N G N
Sbjct: 374 PQPTIKWRVNGSPVD--NHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANAN 431
Query: 301 ASLVLFRP 308
+V RP
Sbjct: 432 IDVVDVRP 439
Score = 39.3 bits (90), Expect = 0.005
Identities = 50/206 (24%), Positives = 72/206 (34%), Gaps = 25/206 (12%)
Query: 109 YTCSVQTQHEPKTSQVYL-IVQVPPKISNISSD--VTVNEGSNVTLVCMANGRPEPVITW 165
Y C H + + +V V P I + TV G + L C PE V++W
Sbjct: 415 YQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATV-VGYSAFLHCEFFASPEAVVSW 473
Query: 166 RHLTPT----GREFE-GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPT 220
+ + GR + E L+I T E +G Y C N + V N
Sbjct: 474 QKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKL 533
Query: 221 ITESKSNEATTGRQASL----KCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQ---- 272
K+ L KC++ + W +D EI TE
Sbjct: 534 RVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD------GEAFEINGTEDGRIII 587
Query: 273 --SSLTVTNVTEEHYGNYTCVAANKL 296
++LT++NVT E G Y C A L
Sbjct: 588 DGANLTISNVTLEDQGIYCCSAHTAL 613
Score = 37.0 bits (84), Expect = 0.025
Identities = 28/105 (26%), Positives = 40/105 (38%), Gaps = 13/105 (12%)
Query: 208 VKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIK 267
+KQ KV V +P ++CEA P P F W +D + I
Sbjct: 38 IKQSKVQVAFP------------FDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIP 85
Query: 268 STEGQSSLTVTNVTEEHY-GNYTCVAANKLGVTNASLVLFRPGSV 311
S + H+ G Y C A+NKLG+ + + F SV
Sbjct: 86 SNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
Score = 33.1 bits (74), Expect = 0.36
Identities = 43/182 (23%), Positives = 62/182 (34%), Gaps = 20/182 (10%)
Query: 127 IVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE------ 180
+ QVP I V + C A G PEP +W T G F +
Sbjct: 31 VQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSW---TKDGNPFYFTDHRIIPSN 87
Query: 181 -----YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSN--EATTGR 233
+ G GKY C A+N++ A ++++ V P + K + E G
Sbjct: 88 NSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGD 147
Query: 234 QASLKCE-ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGN-YTCV 291
L C +P W + + S +G L NV E+ N Y C
Sbjct: 148 PIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG--DLYFANVEEKDSRNDYCCF 205
Query: 292 AA 293
AA
Sbjct: 206 AA 207
>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
Length = 437
Score = 87.0 bits (214), Expect = 2e-17
Identities = 87/321 (27%), Positives = 140/321 (43%), Gaps = 51/321 (15%)
Query: 20 LCLLPTGLPVRSVDFNRG----TDNITVRQGDTAILRCVVEDK-NSKVAWLNRSGIIFAG 74
L L+P V ++G T N+TV +G TAIL C V+ N+ + W N +
Sbjct: 9 LSLVPAAASKNKVKGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYF 68
Query: 75 HDKWSL-DPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYL-IVQVP- 131
DK +L D R+EL + E S+ + V + DEG YTCS+ T KTS+ YL ++ VP
Sbjct: 69 DDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTM-PVKTSKAYLTVLGVPE 127
Query: 132 -PKISNISSDVTVNEGSNVTLVCMANG-RPEPVITWRHLTPTGREFEGEEEYLEILGITR 189
P+IS SS V EG + L C +G +P I W F+ ++E ++ +
Sbjct: 128 KPQISGFSSPVM--EGDLMQLTCKTSGSKPAADIRW---------FKNDKEIKDVKYLKE 176
Query: 190 EQSGKYE---------------------CKAANEVSSA--DVKQVKVTVNYPPTITESKS 226
E + + C+ +E +A V + ++Y P++ S
Sbjct: 177 EDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPS 236
Query: 227 NE-ATTGRQASLKCEASAVPAPD-FEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEH 284
G+ L CE+ P P+ W +D + + + + E L + + +
Sbjct: 237 TPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRE----LNILFLNKTD 292
Query: 285 YGNYTCVAANKLGVTNASLVL 305
G Y C A N +G ++A VL
Sbjct: 293 NGTYRCEATNTIGQSSAEYVL 313
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/134 (27%), Positives = 58/134 (43%), Gaps = 16/134 (11%)
Query: 100 KVDVYDEG-SYTCSVQTQHEPKTSQV---YLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
+VD D+G + C V + T QV L + P + I S EG + L C +
Sbjct: 193 RVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCES 252
Query: 156 NGRP--EPVITWRHLTPTGREFEGEEEY------LEILGITREQSGKYECKAANEVSSAD 207
G+P EPV+ W T G E + L IL + + +G Y C+A N + +
Sbjct: 253 KGKPLPEPVL-W---TKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSS 308
Query: 208 VKQVKVTVNYPPTI 221
+ V + + P T+
Sbjct: 309 AEYVLIVHDVPNTL 322
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 86.3 bits (212), Expect = 4e-17
Identities = 66/232 (28%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLV 152
+Y+LRI+K DEG+Y C + + + L V+ PP+ D V +G VT
Sbjct: 291 DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP 350
Query: 153 CMANGRPEPVITWRHLTPTGREFEGEEEY------------LEILGITREQSGKYECKAA 200
C G P+P + W+ F + + L I I R +G Y C+A
Sbjct: 351 CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQAL 410
Query: 201 NEVSSADVK-QVKV----TVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRD 254
S K Q++V T PP I + +N+ A LKC+A+ P P W ++
Sbjct: 411 TVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKE 470
Query: 255 DTRINSANGLEIKST-EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ G + ++T + Q +L + N+ G YTCVA + G T+ S VL
Sbjct: 471 GF---TFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 519
Score = 62.4 bits (150), Expect = 6e-10
Identities = 61/208 (29%), Positives = 83/208 (39%), Gaps = 34/208 (16%)
Query: 131 PPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW-----------------RHLTPTGR 173
PP+I SDV V++G TL C A GRP P I W R L P+G
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 174 EFEGEEEYLEILGITREQ--SGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNE--A 229
F +L I+ R + G Y C A N + A + + V +
Sbjct: 106 LF-----FLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 160
Query: 230 TTGRQASLKCE-ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNY 288
G A L+C+ P P W +D RI+ E S G L ++N + G Y
Sbjct: 161 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE--ERISIRG-GKLMISNTRKSDAGMY 217
Query: 289 TCVAANKLGVTN---ASLVLF-RPGSVR 312
TCV N +G + A L +F RP +R
Sbjct: 218 TCVGTNMVGERDSDPAELTVFERPTFLR 245
Score = 62.0 bits (149), Expect = 7e-10
Identities = 67/276 (24%), Positives = 97/276 (35%), Gaps = 22/276 (7%)
Query: 33 DFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
DF + ++ V G+ AIL C + + I+ DK +D + E+R S+
Sbjct: 150 DFRQNPTDVVVAAGEPAILECQPPRGHPEPT-------IYWKKDKVRIDDK---EERISI 199
Query: 93 EYS-LRIQKVDVYDEGSYTC-SVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVT 150
L I D G YTC E + L V P + V E V
Sbjct: 200 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE 259
Query: 151 LVCMANGRPEPVITWRHLT---PTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C G P+P + W+ P GR ++ L I G Y C A N V +
Sbjct: 260 FRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME 319
Query: 208 VKQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTR----INSAN 262
+TV PP + + GR + CE P P W ++ ++ N
Sbjct: 320 A-SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 378
Query: 263 GLEIK-STEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ S LT+TN+ G Y C A G
Sbjct: 379 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Score = 36.2 bits (82), Expect = 0.043
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 36 RGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
+G N T+ TA+L+C D ++WL + G F G DPR ++++ +L+
Sbjct: 438 QGPANQTLAVDGTALLKCKATGDPLPVISWL-KEGFTFPGR-----DPRATIQEQGTLQ- 490
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTS 122
I+ + + D G+YTC V T +TS
Sbjct: 491 ---IKNLRISDTGTYTC-VATSSSGETS 514
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 86.3 bits (212), Expect = 4e-17
Identities = 66/232 (28%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 93 EYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLV 152
+Y+LRI+K DEG+Y C + + + L V+ PP+ D V +G VT
Sbjct: 275 DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP 334
Query: 153 CMANGRPEPVITWRHLTPTGREFEGEEEY------------LEILGITREQSGKYECKAA 200
C G P+P + W+ F + + L I I R +G Y C+A
Sbjct: 335 CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQAL 394
Query: 201 NEVSSADVK-QVKV----TVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRD 254
S K Q++V T PP I + +N+ A LKC+A+ P P W ++
Sbjct: 395 TVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKE 454
Query: 255 DTRINSANGLEIKST-EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
+ G + ++T + Q +L + N+ G YTCVA + G T+ S VL
Sbjct: 455 GF---TFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 503
Score = 62.4 bits (150), Expect = 6e-10
Identities = 61/208 (29%), Positives = 83/208 (39%), Gaps = 34/208 (16%)
Query: 131 PPKISNISSDVTVNEGSNVTLVCMANGRPEPVITW-----------------RHLTPTGR 173
PP+I SDV V++G TL C A GRP P I W R L P+G
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 174 EFEGEEEYLEILGITREQ--SGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNE--A 229
F +L I+ R + G Y C A N + A + + V +
Sbjct: 90 LF-----FLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
Query: 230 TTGRQASLKCE-ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNY 288
G A L+C+ P P W +D RI+ E S G L ++N + G Y
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE--ERISIRG-GKLMISNTRKSDAGMY 201
Query: 289 TCVAANKLGVTN---ASLVLF-RPGSVR 312
TCV N +G + A L +F RP +R
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERPTFLR 229
Score = 62.0 bits (149), Expect = 7e-10
Identities = 67/276 (24%), Positives = 97/276 (35%), Gaps = 22/276 (7%)
Query: 33 DFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL 92
DF + ++ V G+ AIL C + + I+ DK +D + E+R S+
Sbjct: 134 DFRQNPTDVVVAAGEPAILECQPPRGHPEPT-------IYWKKDKVRIDDK---EERISI 183
Query: 93 EYS-LRIQKVDVYDEGSYTC-SVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVT 150
L I D G YTC E + L V P + V E V
Sbjct: 184 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE 243
Query: 151 LVCMANGRPEPVITWRHLT---PTGREFEGEEEYLEILGITREQSGKYECKAANEVSSAD 207
C G P+P + W+ P GR ++ L I G Y C A N V +
Sbjct: 244 FRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME 303
Query: 208 VKQVKVTVNYPPT-ITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTR----INSAN 262
+TV PP + + GR + CE P P W ++ ++ N
Sbjct: 304 A-SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 362
Query: 263 GLEIK-STEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ S LT+TN+ G Y C A G
Sbjct: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Score = 36.2 bits (82), Expect = 0.043
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 36 RGTDNITVRQGDTAILRC-VVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEY 94
+G N T+ TA+L+C D ++WL + G F G DPR ++++ +L+
Sbjct: 422 QGPANQTLAVDGTALLKCKATGDPLPVISWL-KEGFTFPGR-----DPRATIQEQGTLQ- 474
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTS 122
I+ + + D G+YTC V T +TS
Sbjct: 475 ---IKNLRISDTGTYTC-VATSSSGETS 498
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/281 (25%), Positives = 105/281 (37%), Gaps = 34/281 (12%)
Query: 36 RGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95
R + + + L V D ++ W G + G R E+ HSL
Sbjct: 263 RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG--------RYEIRSDHSLW-- 312
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMA 155
I V DEG+YTC + + L V VPP++ D G +V C
Sbjct: 313 --IGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCET 370
Query: 156 NGRPEPVITW------------RHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEV 203
G P P I W + L PTGR L I + R +G Y C+A +
Sbjct: 371 KGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVA 430
Query: 204 SS------ADVKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFEWYRDDT 256
S ++K + PP I + +N+ G L C + P P W +D
Sbjct: 431 GSILAKALLEIKGASLD-GLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQ 489
Query: 257 RINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ + L+ K T +L + NV E G Y+CVA + G
Sbjct: 490 WL-QGDDLQFK-TMANGTLYIANVQEMDMGFYSCVAKSSTG 528
Score = 71.6 bits (174), Expect = 9e-13
Identities = 75/316 (23%), Positives = 120/316 (37%), Gaps = 34/316 (10%)
Query: 33 DFNRGTDNITVRQGDTAILRCVVE--DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRH 90
DF + N+ V G+ A+L CV V+W + G + +L H
Sbjct: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSW-RKDGARLKEEEGRITIRGGKLMMSH 225
Query: 91 SLEYSLRIQKVDVYDEGSYTCSVQTQ-HEPKTSQVYLIVQVPPKISNISSDVTVNEGSNV 149
+L+ D G Y C E +++ ++V P + V + V
Sbjct: 226 TLK----------SDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPV 275
Query: 150 TLVCMANGRPEPVITWRH---LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSA 206
T +C G P P + WR PTGR + L I ++ E G Y C A N V A
Sbjct: 276 TFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRA 335
Query: 207 DVKQVKVTVNYPP-TITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRI-----NS 260
+ ++V+ PP +T+ + A G + +CE P P W ++ +++ S
Sbjct: 336 EASG-SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQS 394
Query: 261 ANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG---------VTNASLVLFRPGSV 311
S + L +T V G Y C A + G + ASL P +
Sbjct: 395 LQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL 454
Query: 312 RG-INGSISLAVPLWL 326
+G N ++ L +WL
Sbjct: 455 QGPANQTLVLGSSVWL 470
Score = 65.5 bits (158), Expect = 7e-11
Identities = 60/230 (26%), Positives = 89/230 (38%), Gaps = 31/230 (13%)
Query: 105 DEGSYTCSVQTQHEPKTSQ--VYLIVQVPPKISNISSDVTVNEGSNVTLVCMA-NGRPEP 161
DEG YTC + S+ + + +V V G L C+ G PEP
Sbjct: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
Query: 162 VITWRHLTPTGREFEGEEEYLEILG-------ITREQSGKYECKAANEVSSADVKQVKVT 214
++WR G + EE + I G + +G Y C A+N + +V
Sbjct: 197 SVSWRK---DGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVM 253
Query: 215 VNYPPTITESKSNEATTG-RQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQS 273
V P+ N+ + CE P P W ++D + + EI+S
Sbjct: 254 VLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGR-YEIRSDH--- 309
Query: 274 SLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINGSISLAVP 323
SL + +V+ E G YTCVA N +G AS GS+S+ VP
Sbjct: 310 SLWIGHVSAEDEGTYTCVAENSVGRAEAS-------------GSLSVHVP 346
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/216 (26%), Positives = 82/216 (37%), Gaps = 34/216 (15%)
Query: 132 PKISNISSDVTVNEGSNVTLVCMANGRPEPVITW-----------------RHLTPTGRE 174
P+I D+ V+ G TL C A GRP P I W R L P+G
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
Query: 175 FEGEEEYLEIL--GITREQSGKYECKAANEVSSADVKQVKVTVN-YPPTITESKSN-EAT 230
F + I+ R G Y C A N + +A + + V +S N
Sbjct: 124 F-----FPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178
Query: 231 TGRQASLKC-EASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYT 289
G A L+C P P W +D R+ G + T L +++ + G Y
Sbjct: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMYV 235
Query: 290 CVAANKLGVTNAS----LVLFRPGSVRGINGSISLA 321
CVA+N G ++ +VL RP +R + LA
Sbjct: 236 CVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLA 271
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 84.3 bits (207), Expect = 1e-16
Identities = 71/242 (29%), Positives = 97/242 (40%), Gaps = 33/242 (13%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI-VQVPPKISNISSDVTVNEGSNVTLVCM 154
L VD D G+Y+C + Y++ V IS D V+ G+ V C
Sbjct: 275 LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCD 334
Query: 155 ANGRPEPVITWRH----LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVS---SAD 207
+G P P TW H + P+ R L+I G+T E G Y+C A N + S
Sbjct: 335 VHGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTG 393
Query: 208 VKQVKVTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINS------ 260
+++ + P I T S + G +L C AS +P P WY I S
Sbjct: 394 RLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVL 453
Query: 261 -----------ANGLEIK------STEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASL 303
GL ++ S G SSL + VT+EH G Y C AAN+ G T A
Sbjct: 454 RSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEA 513
Query: 304 VL 305
L
Sbjct: 514 SL 515
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/276 (23%), Positives = 109/276 (39%), Gaps = 45/276 (16%)
Query: 46 GDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYD 105
G +L C + ++++WL H+ +LD +E K H + +L I ++
Sbjct: 43 GGPVVLHCSAQPVTTRISWL---------HNGKTLDGNLEHVKIH--QGTLTILSLNSSL 91
Query: 106 EGSYTCSVQTQ-----HEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVC-MANGRP 159
G Y C P T V ++ ++ +T E S + C + P
Sbjct: 92 LGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHV---ITAEEKSAGFIGCRVPESNP 148
Query: 160 EPVITWRHLTPTGREFEGEEEY--------LEILGITREQSGKYECKAANEVS-SADVKQ 210
+ + ++ G+ E E L+IL ++ E G Y+C A N V+ V+
Sbjct: 149 KAEVRYKI---RGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEP 205
Query: 211 V--KVTVNYPPTI-------TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSA 261
+ K+ V+ P + T S++ + +L+C S VPAP W +D I
Sbjct: 206 IGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPG 265
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLG 297
+ S L +V GNY+C+A NK G
Sbjct: 266 SNWR----RLYSHLATDSVDPADSGNYSCMAGNKSG 297
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 84.0 bits (206), Expect = 2e-16
Identities = 68/281 (24%), Positives = 115/281 (40%), Gaps = 28/281 (9%)
Query: 41 ITVRQGDTAILRCVVEDKNSKV--AWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRI 98
++VR+G +L C + ++ +W+ F D R + + +L I
Sbjct: 205 VSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDS-----RRFISQETG---NLYI 256
Query: 99 QKVDVYDEGSYTCSVQTQH------EPKTSQVY----LIVQVPPKIS-NISSDVTVNEGS 147
KV D GSY C V+ P T ++ + PKI + VT +G+
Sbjct: 257 SKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGT 316
Query: 148 NVTLVCMANGRPEPVITWRHLT---PTGREFEGEEEYLEILGITREQSGKYECKAANEVS 204
V + C A G P P ITW + P+ + LEI + + +G YEC+A N
Sbjct: 317 TVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRG 376
Query: 205 SADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGL 264
+ YP + + + +G +C+A+ P P + W ++ ++ + +
Sbjct: 377 KNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV 436
Query: 265 EIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVL 305
E+ + L + NV + G Y C+A NK G AS L
Sbjct: 437 EMVN----GVLMIHNVNQSDAGMYQCLAENKYGAIYASAEL 473
Score = 60.5 bits (145), Expect = 2e-09
Identities = 48/209 (22%), Positives = 85/209 (40%), Gaps = 15/209 (7%)
Query: 96 LRIQKVDVYDEGSYTCSVQTQHEP--KTSQVYLIVQVPP-KISNISSDVTVNEGSNVTLV 152
L I V+ D G Y C + ++ ++++ ++ P ++ + + V + V +
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 502
Query: 153 CMANGRPEPVITWRHLTPTGREFEG----EEEYLEILGITREQSGKYECKAANEVSSADV 208
C G P+P I+W+ RE + + L IL ++ GKY C+ N SA++
Sbjct: 503 CKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEI 562
Query: 209 KQVKVTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRD------DTRINSA 261
++V P I K E T G L C+A + D +Y D
Sbjct: 563 -IASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGG 621
Query: 262 NGLEIKSTEGQSSLTVTNVTEEHYGNYTC 290
+ I++ + L + N+ H G Y C
Sbjct: 622 HFESIRAQASSADLMIRNILLMHAGRYGC 650
Score = 39.7 bits (91), Expect = 0.004
Identities = 24/102 (23%), Positives = 47/102 (46%), Gaps = 7/102 (6%)
Query: 201 NEVSSADVKQVKVTVNYPPTITESKSN----EATTGRQASLKCEASAVPAPDFEWYRDDT 256
N S+D + +V+Y P + + + ++ +L CE P P + W R+ T
Sbjct: 81 NLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGT 140
Query: 257 RINSANGLEIKSTEGQSSLTVTNVTE-EHYGNYTCVAANKLG 297
I+ + +G + ++N +E + G+Y C+A N +G
Sbjct: 141 EIDLESDYRYSLIDG--TFIISNPSEAKDSGHYQCLATNTVG 180
Score = 33.1 bits (74), Expect = 0.36
Identities = 38/175 (21%), Positives = 63/175 (36%), Gaps = 17/175 (9%)
Query: 142 TVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEIL---------GITREQS 192
T ++ V L C G P P W G E + E +Y L + S
Sbjct: 112 TDSDEKKVALNCEVRGNPVPSYRWLR---NGTEIDLESDYRYSLIDGTFIISNPSEAKDS 168
Query: 193 GKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATT--GRQASLKCEASA-VPAPDF 249
G Y+C A N V S ++ + Y + + + G+ L C P +
Sbjct: 169 GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIY 228
Query: 250 EWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLV 304
W ++ A ++ +L ++ V G+Y C+ N VTNA ++
Sbjct: 229 SWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNT--VTNARVL 281
Score = 31.2 bits (69), Expect = 1.4
Identities = 33/139 (23%), Positives = 50/139 (35%), Gaps = 16/139 (11%)
Query: 95 SLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCM 154
SLRI DEG Y C + L V+ P +I + G ++ L C
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCK 594
Query: 155 ANGRPEPVITWRHLTPTGREFEGEEE--------------YLEILGITREQSGKYECKAA 200
A +T+ + T G+ + EEE L I I +G+Y C+
Sbjct: 595 AIHDASLDVTF-YWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQ 653
Query: 201 NEVSSADVKQVKVTVNYPP 219
S + ++ V PP
Sbjct: 654 TTADSVS-DEAELLVRGPP 671
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,087,541
Number of Sequences: 37866
Number of extensions: 571548
Number of successful extensions: 6073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 1613
Number of HSP's gapped (non-prelim): 2402
length of query: 338
length of database: 18,247,518
effective HSP length: 103
effective length of query: 235
effective length of database: 14,347,320
effective search space: 3371620200
effective search space used: 3371620200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.