Search of human proteins with 13186302

Search of human proteins with 13186302

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13186302 calpain 10 isoform a [Homo sapiens]
         (672 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13186302 calpain 10 isoform a [Homo sapiens]                      1410   0.0  
gi|89353291 calpain 10 isoform c [Homo sapiens]                       937   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                236   4e-62
gi|38707981 calpain 12 [Homo sapiens]                                 236   4e-62
gi|221554549 calpain 8 [Homo sapiens]                                 230   3e-60
gi|12408656 calpain 1, large subunit [Homo sapiens]                   223   6e-58
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       220   3e-57
gi|27765074 calpain 3 isoform c [Homo sapiens]                        220   4e-57
gi|37577157 calpain 5 [Homo sapiens]                                  218   1e-56
gi|4557405 calpain 3 isoform a [Homo sapiens]                         215   9e-56
gi|27765072 calpain 3 isoform b [Homo sapiens]                        215   9e-56
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         202   6e-52
gi|47078247 calpain 3 isoform f [Homo sapiens]                        199   7e-51
gi|13186314 calpain 10 isoform g [Homo sapiens]                       198   2e-50
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       198   2e-50
gi|10864059 calpain 10 isoform h [Homo sapiens]                       186   6e-47
gi|223468608 calpain 14 [Homo sapiens]                                184   2e-46
gi|13186316 calpain 6 [Homo sapiens]                                  180   4e-45
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         174   2e-43
gi|41152101 calpain 13 [Homo sapiens]                                 155   1e-37
gi|5032105 small optic lobes [Homo sapiens]                           123   5e-28
gi|7656959 calpain 7 [Homo sapiens]                                    94   5e-19
gi|27765076 calpain 3 isoform d [Homo sapiens]                         39   0.016
gi|239752515 PREDICTED: similar to double homeobox, 4 [Homo sapi...    32   2.5  
gi|90903231 huntingtin [Homo sapiens]                                  30   5.5  
gi|239744246 PREDICTED: hypothetical protein XP_002343082 [Homo ...    30   5.5  
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi...    30   7.2  
gi|239757286 PREDICTED: similar to Fc fragment of IgG binding pr...    30   9.5  
gi|169213727 PREDICTED: hypothetical protein [Homo sapiens]            30   9.5  
gi|239753407 PREDICTED: hypothetical protein [Homo sapiens]            30   9.5  

>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score = 1410 bits (3649), Expect = 0.0
 Identities = 672/672 (100%), Positives = 672/672 (100%)

Query: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60
           MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP
Sbjct: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60

Query: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV 120
           REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV
Sbjct: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV 120

Query: 121 EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG 180
           EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG
Sbjct: 121 EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG 180

Query: 181 LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF 240
           LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF
Sbjct: 181 LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF 240

Query: 241 IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE 300
           IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE
Sbjct: 241 IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE 300

Query: 301 FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG 360
           FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG
Sbjct: 301 FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG 360

Query: 361 FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV 420
           FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV
Sbjct: 361 FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV 420

Query: 421 GLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGE 480
           GLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGE
Sbjct: 421 GLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGE 480

Query: 481 FLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPT 540
           FLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPT
Sbjct: 481 FLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPT 540

Query: 541 NPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPL 600
           NPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPL
Sbjct: 541 NPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPL 600

Query: 601 LSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQF 660
           LSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQF
Sbjct: 601 LSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQF 660

Query: 661 LQEVSVMAVMKT 672
           LQEVSVMAVMKT
Sbjct: 661 LQEVSVMAVMKT 672


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  937 bits (2421), Expect = 0.0
 Identities = 447/487 (91%), Positives = 455/487 (93%), Gaps = 2/487 (0%)

Query: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60
           MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP
Sbjct: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60

Query: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV 120
           REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV
Sbjct: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV 120

Query: 121 EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG 180
           EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG
Sbjct: 121 EVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGG 180

Query: 181 LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF 240
           LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF
Sbjct: 181 LAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAF 240

Query: 241 IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE 300
           IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE
Sbjct: 241 IVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGE 300

Query: 301 FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG 360
           FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG
Sbjct: 301 FWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG 360

Query: 361 FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV 420
           FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV
Sbjct: 361 FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAV 420

Query: 421 GLHLWKVEK--RRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAP 478
           GLHLWKV +  R  + P +L   P+     H Y +EV   C L  G Y  VPST+L D  
Sbjct: 421 GLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTE 480

Query: 479 GEFLLRV 485
           G F + +
Sbjct: 481 GAFTVTI 487



 Score =  211 bits (538), Expect = 1e-54
 Identities = 118/182 (64%), Positives = 129/182 (70%), Gaps = 28/182 (15%)

Query: 516 TVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCR--------- 566
           T  L G+W  GQ+AGG RN + +P+NP F   V E   P  V I + Q  R         
Sbjct: 339 TRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSE---PSEVYIAVLQRSRLHAADWAGR 395

Query: 567 ------PSDTEFHP----------IGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQ 610
                  S T + P          +G H+++VPEGGRSQDAPPLLLQEPLLSCVPHRYAQ
Sbjct: 396 ARALVGDSHTSWSPASIPGKHYQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQ 455

Query: 611 EVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSVMAVM 670
           EVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSVMAVM
Sbjct: 456 EVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSVMAVM 515

Query: 671 KT 672
           KT
Sbjct: 516 KT 517


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  236 bits (603), Expect = 4e-62
 Identities = 166/493 (33%), Positives = 237/493 (48%), Gaps = 47/493 (9%)

Query: 12  ELFRDAAFPAADSSL-FCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLL 70
           ELF D  FPA  SSL F DL  P ++  ++I+W+RP++I   P    D      + QG+L
Sbjct: 78  ELFEDPLFPAEPSSLGFKDLG-PNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGIL 136

Query: 71  GDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPC 130
           GDCW L A  +L     LL +V+P GQ     + Y G F  +IWQFG+WV V  DDRLP 
Sbjct: 137 GDCWLLAAIGSLTTCPKLLYRVVPRGQSF--KKNYAGIFHFQIWQFGQWVNVVVDDRLPT 194

Query: 131 LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
              +L F        FW  LLEK YAK+ GSYE L  G   + L D TGG+A+ + L+  
Sbjct: 195 KNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-- 252

Query: 191 AGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSD 244
                   RP +   R  R+   ++   L+ C +        E      L   HA+ V+ 
Sbjct: 253 --------RPPQNLLRLLRKA--VERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTG 302

Query: 245 LRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVE 304
           L+++    G+   L+R++NPWGR  W G W +    W +V + +  +LL + ++GEFW+ 
Sbjct: 303 LQDVH-YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMS 361

Query: 305 EEEFLREFDELTVG--YPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG-F 361
            ++FL  F  L +    P T +G  +S +      HT    G+W +G SAGGCRN+ G F
Sbjct: 362 YQDFLNNFTLLEICNLTPDTLSGDYKSYW------HTTFYEGSWRRGSSAGGCRNHPGTF 415

Query: 362 PSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVG 421
            +NP+F + + E  +            A         LV     +W  A   G   Q +G
Sbjct: 416 WTNPQFKISLPEGDD--------PEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIG 467

Query: 422 LHLWKVEKRRVNLPRV-LSMPPVAGTACHAY------DREVHLRCELSPGYYLAVPSTFL 474
             L+ V K   N+  V L          H +       REV  +  L PG Y+ +PSTF 
Sbjct: 468 FVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFE 527

Query: 475 KDAPGEFLLRVFS 487
                +FLLRVF+
Sbjct: 528 PHRDADFLLRVFT 540



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 54/176 (30%), Positives = 76/176 (43%), Gaps = 25/176 (14%)

Query: 514 WGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPEGPGPR-----------CVRITL 561
           W T    GSWR G +AGG RN   ++ TNP F  S+PEG  P            C+   +
Sbjct: 390 WHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALM 449

Query: 562 H---QHCRPSDTEFHPIGFHIFQVP-EGGRSQDAPPLLLQEPLLSCVPHRYAQ------E 611
               +H R    +   IGF ++ VP E    QD    L +E       H +++      E
Sbjct: 450 QKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVH--LKKEFFTKYQDHGFSEIFTNSRE 507

Query: 612 VSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEM-LGQFLQEVSV 666
           VS    LP G Y ++PST+ P  +  F + + T     S    E+   + LQE  V
Sbjct: 508 VSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKV 563


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  236 bits (603), Expect = 4e-62
 Identities = 177/541 (32%), Positives = 249/541 (46%), Gaps = 64/541 (11%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LFRD  FPA   +L  D   P ++  + + W RP E CA P+   +D     V QG LG+
Sbjct: 45  LFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGN 104

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CWFL A A+L     LL +V+PPGQ       Y G F  ++WQFGRW++V  DDRLP   
Sbjct: 105 CWFLAAAASLTLYPRLLRRVVPPGQDF--QHGYAGVFHFQLWQFGRWMDVVVDDRLPVRE 162

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
           G+L F R ++ + FW PLLEK YAK+HGSYE +  G + +A VD TGG+ E   L+    
Sbjct: 163 GKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR---- 218

Query: 193 SGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE---LGEFHAFIVSDLREL 248
               Q+  G +       L H L  + L+    LS R   R    L + HA+ ++   ++
Sbjct: 219 ----QNSMGLFS-----ALRHALAKESLVGATALSDRGEYRTEEGLVKGHAYSITGTHKV 269

Query: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEF 308
                  + LLR++NPWG   W G W +    W  +       LL + ++GEFW+E  +F
Sbjct: 270 -FLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWMELRDF 328

Query: 309 LREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNS-GFPSNPKF 367
           L  FD + +    + +  +     E    H     G WV+G ++GG + N+  F +NP+F
Sbjct: 329 LLHFDTVQI---CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQF 385

Query: 368 WLRVSEPSEVYIAVLQRSRLHAADWAG-RARALVGDSHTSWSP---------------AS 411
            L + EP E      +        W G  A    G +    +P                 
Sbjct: 386 RLTLLEPDE------EDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLR 439

Query: 412 IPGKHYQAVGLH----------LWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCEL 461
             G  Y  VG H          LW   +    LPR+L     A  +  +  R+V  RC L
Sbjct: 440 AKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLR----ADRSPLSARRDVTRRCCL 495

Query: 462 SPGYYLAVPSTFLKDAPGEFLLRVFSTGR---VSLSAIRAVAKNTTPGAALPAGEWGTVQ 518
            PG+YL VPST       +F LRVFS  R   V +  + +    +  G  LP  E G  Q
Sbjct: 496 RPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPL-ELGLEQ 554

Query: 519 L 519
           L
Sbjct: 555 L 555



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 51/199 (25%), Positives = 79/199 (39%), Gaps = 43/199 (21%)

Query: 506 GAALPAGEWGTVQLRGSWRVGQTAGGSR-NFASYPTNPCFPFSVPE-------------- 550
           G +   G W     +G W  G  +GGS+ N  ++ TNP F  ++ E              
Sbjct: 346 GPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWG 405

Query: 551 -------------GPGPRC-VRITLHQH----CRPSDTEFHPIGFHIFQVPE-------G 585
                        G  P+C V ++L Q      R     +  +GFH+FQ+PE        
Sbjct: 406 GWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDS 465

Query: 586 GRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATR 645
            RS    P LL+       P    ++V+R C L  G Y VVPST     E  FT+ + + 
Sbjct: 466 PRSHALLPRLLRADRS---PLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522

Query: 646 IDRPSIHSQEMLGQFLQEV 664
               ++   +++   LQ +
Sbjct: 523 RRHTAVEIDDVISADLQSL 541


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  230 bits (587), Expect = 3e-60
 Identities = 158/494 (31%), Positives = 242/494 (48%), Gaps = 52/494 (10%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF+D  FPA  S+L      P +   + I W+RP E+C +P+          + QG LGD
Sbjct: 45  LFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGD 104

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CW L A A+L  +  LL +V+P  Q     + Y G F  + WQ+G WVEV  DDRLP   
Sbjct: 105 CWLLAAIASLTLNEELLYRVVPRDQDF--QENYAGIFHFQFWQYGEWVEVVIDDRLPTKN 162

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
           G+L F   ++ + FW  LLEK YAK++G YE L  G   +   D TGG++E ++LK    
Sbjct: 163 GQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK---- 218

Query: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCV-LSPRAGA-----RELGEFHAFIVSDLR 246
                 +P    ++  R+ L      L+ C + +S  A A     ++L + HA+ V+ + 
Sbjct: 219 ------KPPANLYQIIRKALCAGS--LLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVE 270

Query: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
           E+  Q G    L+R++NPWG   W G W +    W+ +D     EL  ++++GEFW+   
Sbjct: 271 EVNFQ-GHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLS 329

Query: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
           +F+R+F  L +     ++   + ++   L+       G W +G +AGGC+N  + + +NP
Sbjct: 330 DFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFN----GHWTRGSTAGGCQNYPATYWTNP 385

Query: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413
           +F +R+ E  E            V + ++Q++R     W  R R   G     ++   +P
Sbjct: 386 QFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNR----RW--RKRIGQGMLSIGYAVYQVP 439

Query: 414 GKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTF 473
            +       HL +           L+  P A T+ +   REV  R  L PG YL VPSTF
Sbjct: 440 KELESHTDAHLGR--------DFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTF 491

Query: 474 LKDAPGEFLLRVFS 487
                GEF LRVFS
Sbjct: 492 EPFKDGEFCLRVFS 505



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 513 EWGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPE-------GPGPRCVRITL--- 561
           +W  V   G W  G TAGG +N+ A+Y TNP F   + E         G  C  + L   
Sbjct: 355 KWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLM 414

Query: 562 ---HQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPL-----LLQEPLLSCVPHRYAQEVS 613
               +  +        IG+ ++QVP+   S     L     L  +P      +   +EVS
Sbjct: 415 QKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVS 474

Query: 614 RLCLLPAGTYKVVPSTYLPDTEGAFTVTI 642
               LP G Y VVPST+ P  +G F + +
Sbjct: 475 GRARLPPGEYLVVPSTFEPFKDGEFCLRV 503


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  223 bits (567), Expect = 6e-58
 Identities = 159/501 (31%), Positives = 231/501 (46%), Gaps = 66/501 (13%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LFRD AFP    SL      P +     I W+RP E+ + P+   D      + QG LGD
Sbjct: 55  LFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGD 114

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CW L A A+L  +  LL +V+P GQ       Y G F  ++WQFG WV+V  DD LP   
Sbjct: 115 CWLLAAIASLTLNDTLLHRVVPHGQSF--QNGYAGIFHFQLWQFGEWVDVVVDDLLPIKD 172

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
           G+L F      + FW  LLEK YAKV+GSYE L  G  ++   D TGG+ E + L+    
Sbjct: 173 GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPS 232

Query: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISC-----CVLSPRA-GARELGEFHAFIVSDLR 246
              Q              L  L+   L+ C      VL   A   ++L + HA+ V+  +
Sbjct: 233 DLYQ------------IILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAK 280

Query: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
           ++    GQ + L+R++NPWG   W G W +    W+ VD     +L  ++++GEFW+   
Sbjct: 281 QV-NYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFR 339

Query: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
           +F+REF  L +     +A  L+S    +   +T    G W +G +AGGCRN  + F  NP
Sbjct: 340 DFMREFTRLEICNLTPDA--LKSRTIRK--WNTTLYEGTWRRGSTAGGCRNYPATFWVNP 395

Query: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413
           +F +R+ E  +              +A++Q+ R     +                     
Sbjct: 396 QFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRF--------------------- 434

Query: 414 GKHYQAVGLHLWKVEKRRVNLPRV-LSMPPVAGTACHAYD------REVHLRCELSPGYY 466
           G+  + +G  +++V    V  P V L        A  A        REV  R  L PG Y
Sbjct: 435 GRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEY 494

Query: 467 LAVPSTFLKDAPGEFLLRVFS 487
           + VPSTF  +  G+F+LR FS
Sbjct: 495 VVVPSTFEPNKEGDFVLRFFS 515



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 54/188 (28%), Positives = 79/188 (42%), Gaps = 21/188 (11%)

Query: 502 NTTPGA--ALPAGEWGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPEGPGP---- 554
           N TP A  +    +W T    G+WR G TAGG RN+ A++  NP F   + E   P    
Sbjct: 352 NLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYG 411

Query: 555 ------RCVRITLHQHCRPS---DTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVP 605
                   V   + +H R       +   IGF +++VP     Q A  L     L +   
Sbjct: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471

Query: 606 HRYAQ-----EVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQF 660
            R  Q     EVS    LP G Y VVPST+ P+ EG F +   +     ++   + +   
Sbjct: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531

Query: 661 LQEVSVMA 668
           L +  V++
Sbjct: 532 LPDEQVLS 539


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  220 bits (561), Expect = 3e-57
 Identities = 156/509 (30%), Positives = 230/509 (45%), Gaps = 60/509 (11%)

Query: 10  ARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGL 69
           A  LF+D +FPA  S+L      P +     I W+RP EICA P+          + QG 
Sbjct: 42  AGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGA 101

Query: 70  LGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLP 129
           LGDCW L A A+L  +  +L +V+P  Q     + Y G F  + WQ+G WVEV  DDRLP
Sbjct: 102 LGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAGIFHFQFWQYGEWVEVVVDDRLP 159

Query: 130 CLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKG 189
              G L F        FW  LLEK YAK++G YE L  G   +   D TGG+AE + LK 
Sbjct: 160 TKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK- 218

Query: 190 VAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEF------HAFIVS 243
                    +P     +  ++   L+   L+ C +    A   E   F      HA+ V+
Sbjct: 219 ---------KPPPNLFKIIQKA--LQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVT 267

Query: 244 DLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWV 303
              E++   G    L+RI+NPWG   W G W +    W+ +D      L  + ++GEFW+
Sbjct: 268 GAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWM 326

Query: 304 EEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFP 362
              +FLR +  L +   +T        Y +  L     + G W +G +AGGCRN  + F 
Sbjct: 327 SFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TKMDGNWRRGSTAGGCRNYPNTFW 382

Query: 363 SNPKFWLRVSEPSE----------VYIAVLQRSRLHAADWAGRARALVGDSHT-SWSPAS 411
            NP++ +++ E  E            + ++Q+ R        R R +  D HT  +    
Sbjct: 383 MNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR-------RRQRKMGEDMHTIGFGIYE 435

Query: 412 IPGKHYQAVGLHLWK----VEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYL 467
           +P +      +HL K      + R      +++            REV  R +L PG Y+
Sbjct: 436 VPEELSGQTNIHLSKNFFLTNRARERSDTFINL------------REVLNRFKLPPGEYI 483

Query: 468 AVPSTFLKDAPGEFLLRVFSTGRVSLSAI 496
            VPSTF  +  G+F +RVFS  +    A+
Sbjct: 484 LVPSTFEPNKDGDFCIRVFSEKKADYQAV 512



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 43/147 (29%), Positives = 64/147 (43%), Gaps = 17/147 (11%)

Query: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPE-------GPGPRCVRITLHQ- 563
           +W   ++ G+WR G TAGG RN+  ++  NP +   + E       G       + L Q 
Sbjct: 355 KWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQK 414

Query: 564 ---HCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHR-----YAQEVSRL 615
                R    + H IGF I++VPE    Q    L     L +    R       +EV   
Sbjct: 415 HRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNR 474

Query: 616 CLLPAGTYKVVPSTYLPDTEGAFTVTI 642
             LP G Y +VPST+ P+ +G F + +
Sbjct: 475 FKLPPGEYILVPSTFEPNKDGDFCIRV 501


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  220 bits (560), Expect = 4e-57
 Identities = 160/495 (32%), Positives = 239/495 (48%), Gaps = 55/495 (11%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+AE + ++    
Sbjct: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR---- 242

Query: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP----RAGARELGEFHAFIVSDLREL 248
                D P    ++  ++ +        S   + P       A  L   HA+ V+ L E+
Sbjct: 243 -----DAPSDM-YKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEV 296

Query: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEE 307
             + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++GEFW+  E+
Sbjct: 297 PFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355

Query: 308 FLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNP 365
           F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN    F +NP
Sbjct: 356 FIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNP 410

Query: 366 KFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGK 415
           ++ L++ E       SEV     +A++Q++R       G +   +G +           K
Sbjct: 411 QYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNK 469

Query: 416 HYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLK 475
            +      L+   K R              +  +   REV  R  L P  Y+ VPST+  
Sbjct: 470 QHLQKDFFLYNASKAR--------------SKTYINMREVSQRFRLPPSEYVIVPSTYEP 515

Query: 476 DAPGEFLLRVFSTGR 490
              GEF+LRVFS  R
Sbjct: 516 HQEGEFILRVFSEKR 530



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 381 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 440

Query: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 441 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 500

Query: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642
           LP   Y +VPSTY P  EG F + +
Sbjct: 501 LPPSEYVIVPSTYEPHQEGEFILRV 525


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  218 bits (555), Expect = 1e-56
 Identities = 158/503 (31%), Positives = 236/503 (46%), Gaps = 67/503 (13%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF D  FPA D SL+    TP    R    W+RP+ IC  PRLF D      + QG +G+
Sbjct: 26  LFEDPLFPATDDSLYYK-GTPGPAVR----WKRPKGICEDPRLFVDGISSHDLHQGQVGN 80

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQE--------YRGSFTCRIWQFGRWVEVTT 124
           CWF+ AC++L     L  +VIP     W +QE        Y G F    W+FG WV+V  
Sbjct: 81  CWFVAACSSLASRESLWQKVIP----DWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVI 136

Query: 125 DDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAER 184
           DDRLP +  +L +      + FW  L+EK YAK+ G Y+ L  G  ADALVD TGG++E 
Sbjct: 137 DDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEP 196

Query: 185 WNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFH 238
            +L     +  +  R   +E    R L       LIS  + +  A   E      L + H
Sbjct: 197 IDLTEGDFANDETKRNQLFE----RMLKVHSRGGLISASIKAVTAADMEARLACGLVKGH 252

Query: 239 AFIVSDLRELQGQAG-------QCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASE 291
           A+ V+D+R+++   G       + + ++R++NPWG R W G W +  E W +V  +   +
Sbjct: 253 AYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREK 312

Query: 292 LLSQLQ-EGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWV--- 347
           +   +Q +GEFW+  E+  R F ++ +   V    HL    T         L GAW    
Sbjct: 313 MGVTVQDDGEFWMTFEDVCRYFTDI-IKCRVINTSHLSIHKT----WEEARLHGAWTLHE 367

Query: 348 --KGQSAGGCRNNSG-FPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSH 404
             +    GGC N+   F  NP++   V +P +  +  +Q+    +    G+   L     
Sbjct: 368 DPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENL----- 422

Query: 405 TSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPG 464
                         A+G  ++KVE+ R    R+ S+   A ++ +   R V LR +   G
Sbjct: 423 --------------AIGFDIYKVEENRQY--RMHSLQHKAASSIYINSRSVFLRTDQPEG 466

Query: 465 YYLAVPSTFLKDAPGEFLLRVFS 487
            Y+ +P+TF     GEFLLRVF+
Sbjct: 467 RYVIIPTTFEPGHTGEFLLRVFT 489



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 27/149 (18%)

Query: 514 WGTVQLRGSWRVGQT-----AGGSRNFA-SYPTNPCFPFSV--PEGPGPRCVRITLHQHC 565
           W   +L G+W + +       GG  N   ++  NP + F V  PE     C++    +  
Sbjct: 354 WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRST 413

Query: 566 RPSDT-EFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEV---SRLCLL--- 618
           R     E   IGF I++V E  + +           +  + H+ A  +   SR   L   
Sbjct: 414 RREGKGENLAIGFDIYKVEENRQYR-----------MHSLQHKAASSIYINSRSVFLRTD 462

Query: 619 -PAGTYKVVPSTYLPDTEGAFTVTIATRI 646
            P G Y ++P+T+ P   G F + + T +
Sbjct: 463 QPEGRYVIIPTTFEPGHTGEFLLRVFTDV 491


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  215 bits (548), Expect = 9e-56
 Identities = 166/533 (31%), Positives = 242/533 (45%), Gaps = 83/533 (15%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+A          
Sbjct: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246

Query: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
                     ER +L G +   G          G        +++   D  L+    L P
Sbjct: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306

Query: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270
           R                   A  L   HA+ V+ L E+  + G+ + L+R++NPWG+  W
Sbjct: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365

Query: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329
            G W +  + WS VD    + L  Q+ ++GEFW+  E+F+  F +L +     +A     
Sbjct: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420

Query: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377
           L +++L   T ++  G WV+G SAGGCRN    F +NP++ L++ E       SEV    
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRV 437
            +A++Q++R       G +   +G +           K +      L+   K R      
Sbjct: 481 LVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKAR------ 533

Query: 438 LSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGR 490
                   +  +   REV  R  L P  Y+ VPST+     GEF+LRVFS  R
Sbjct: 534 --------SKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 578



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 429 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 488

Query: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 489 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 548

Query: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642
           LP   Y +VPSTY P  EG F + +
Sbjct: 549 LPPSEYVIVPSTYEPHQEGEFILRV 573


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  215 bits (548), Expect = 9e-56
 Identities = 166/533 (31%), Positives = 242/533 (45%), Gaps = 83/533 (15%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+A          
Sbjct: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246

Query: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
                     ER +L G +   G          G        +++   D  L+    L P
Sbjct: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306

Query: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270
           R                   A  L   HA+ V+ L E+  + G+ + L+R++NPWG+  W
Sbjct: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365

Query: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329
            G W +  + WS VD    + L  Q+ ++GEFW+  E+F+  F +L +     +A     
Sbjct: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420

Query: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377
           L +++L   T ++  G WV+G SAGGCRN    F +NP++ L++ E       SEV    
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRV 437
            +A++Q++R       G +   +G +           K +      L+   K R      
Sbjct: 481 LVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKAR------ 533

Query: 438 LSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGR 490
                   +  +   REV  R  L P  Y+ VPST+     GEF+LRVFS  R
Sbjct: 534 --------SKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 578



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 429 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 488

Query: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 489 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 548

Query: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642
           LP   Y +VPSTY P  EG F + +
Sbjct: 549 LPPSEYVIVPSTYEPHQEGEFILRV 573


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  202 bits (515), Expect = 6e-52
 Identities = 150/489 (30%), Positives = 225/489 (46%), Gaps = 57/489 (11%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210

Query: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246
                + P  +     +    LK   L+ C + +  A   E      L + HA+ V+ + 
Sbjct: 211 -----EAPENFYEILEKA---LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262

Query: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELL-SQLQEGEFWVEE 305
           ++  + GQ I L+RI+NPWG+  W G W +    W  V  A    L  + L +GEFW+  
Sbjct: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAF 321

Query: 306 EEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSN 364
           ++F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F +N
Sbjct: 322 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVH----QGSWVRGSTAGGCRNFLDTFWTN 377

Query: 365 PKFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQ 418
           P+  L ++E  E        +A++Q+ R     +      +       ++    P K  +
Sbjct: 378 PQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTI------GYAIYECPDKD-E 430

Query: 419 AVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAP 478
            +    ++    R      +++            REV  R +L PG Y+ +PSTF     
Sbjct: 431 HLNKDFFRYHASRARSKTFINL------------REVSDRFKLPPGEYILIPSTFEPHQE 478

Query: 479 GEFLLRVFS 487
            +F LR+FS
Sbjct: 479 ADFCLRIFS 487



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/138 (28%), Positives = 56/138 (40%), Gaps = 8/138 (5%)

Query: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV---PEGPGPRCVRITLHQHCRPS 568
           +W     +GSW  G TAGG RNF  ++ TNP    S+    EG       + L Q  R  
Sbjct: 348 KWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRK 407

Query: 569 DTEFH----PIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYK 624
              F      IG+ I++ P+     +                   +EVS    LP G Y 
Sbjct: 408 LKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467

Query: 625 VVPSTYLPDTEGAFTVTI 642
           ++PST+ P  E  F + I
Sbjct: 468 LIPSTFEPHQEADFCLRI 485


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  199 bits (506), Expect = 7e-51
 Identities = 156/504 (30%), Positives = 229/504 (45%), Gaps = 78/504 (15%)

Query: 42  TWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWA 101
           T ++  EIC  PR   D      + QG LGDCWFL A A L  ++HLL +VIP  Q    
Sbjct: 11  TTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFI- 69

Query: 102 DQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGS 161
            + Y G F  + W++G WV+V  DD LP    +L F++    + FW  LLEK YAK+HGS
Sbjct: 70  -ENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGS 128

Query: 162 YEHLWAGQVADALVDLTGGLA--------------------ERWNLKGVAGSGGQQ---- 197
           YE L  G   +A+ D TGG+A                    ER +L G +   G      
Sbjct: 129 YEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYG 188

Query: 198 -DRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAG-----------------ARELGEFHA 239
               G        +++   D  L+    L PR                   A  L   HA
Sbjct: 189 TSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHA 248

Query: 240 FIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QE 298
           + V+ L E+  + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++
Sbjct: 249 YSVTGLDEVPFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 307

Query: 299 GEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN 357
           GEFW+  E+F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN
Sbjct: 308 GEFWMSYEDFIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRN 362

Query: 358 -NSGFPSNPKFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTS 406
               F +NP++ L++ E       SEV     +A++Q++R       G +   +G +   
Sbjct: 363 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRK-LGASLFTIGFAIYE 421

Query: 407 WSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYY 466
                   K +      L+   K R              +  +   REV  R  L P  Y
Sbjct: 422 VPKEMHGNKQHLQKDFFLYNASKAR--------------SKTYINMREVSQRFRLPPSEY 467

Query: 467 LAVPSTFLKDAPGEFLLRVFSTGR 490
           + VPST+     GEF+LRVFS  R
Sbjct: 468 VIVPSTYEPHQEGEFILRVFSEKR 491



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 342 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 401

Query: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 402 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 461

Query: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642
           LP   Y +VPSTY P  EG F + +
Sbjct: 462 LPPSEYVIVPSTYEPHQEGEFILRV 486


>gi|13186314 calpain 10 isoform g [Homo sapiens]
          Length = 139

 Score =  198 bits (503), Expect = 2e-50
 Identities = 101/131 (77%), Positives = 105/131 (80%), Gaps = 15/131 (11%)

Query: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60
           MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP
Sbjct: 1   MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP 60

Query: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWV 120
           REGQVKQGLLGDCWFLCACAALQKSRHLLDQV  P Q           +TC++     W+
Sbjct: 61  REGQVKQGLLGDCWFLCACAALQKSRHLLDQVSCPVQ-------LPADWTCKVQPV--WL 111

Query: 121 EVTTDDRLPCL 131
           E       PCL
Sbjct: 112 E------FPCL 116


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  198 bits (503), Expect = 2e-50
 Identities = 142/471 (30%), Positives = 211/471 (44%), Gaps = 60/471 (12%)

Query: 48  EICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRG 107
           EICA P+          + QG LGDCW L A A+L  +  +L +V+P  Q     + Y G
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAG 59

Query: 108 SFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWA 167
            F  + WQ+G WVEV  DDRLP   G L F        FW  LLEK YAK++G YE L  
Sbjct: 60  IFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSG 119

Query: 168 GQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
           G   +   D TGG+AE + LK          +P     +  ++   L+   L+ C +   
Sbjct: 120 GATTEGFEDFTGGIAEWYELK----------KPPPNLFKIIQKA--LQKGSLLGCSIDIT 167

Query: 228 RAGARELGEF------HAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGW 281
            A   E   F      HA+ V+   E++   G    L+RI+NPWG   W G W +    W
Sbjct: 168 SAADSEAITFQKLVKGHAYSVTGAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSW 226

Query: 282 SQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRA 341
           + +D      L  + ++GEFW+   +FLR +  L +   +T        Y +  L     
Sbjct: 227 NTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TK 282

Query: 342 LPGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSEPSE----------VYIAVLQRSRLHAA 390
           + G W +G +AGGCRN  + F  NP++ +++ E  E            + ++Q+ R    
Sbjct: 283 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR---- 338

Query: 391 DWAGRARALVGDSHT-SWSPASIPGKHYQAVGLHLWK----VEKRRVNLPRVLSMPPVAG 445
               R R +  D HT  +    +P +      +HL K      + R      +++     
Sbjct: 339 ---RRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINL----- 390

Query: 446 TACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAI 496
                  REV  R +L PG Y+ VPSTF  +  G+F +RVFS  +    A+
Sbjct: 391 -------REVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAV 434



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 43/147 (29%), Positives = 64/147 (43%), Gaps = 17/147 (11%)

Query: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPE-------GPGPRCVRITLHQ- 563
           +W   ++ G+WR G TAGG RN+  ++  NP +   + E       G       + L Q 
Sbjct: 277 KWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQK 336

Query: 564 ---HCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHR-----YAQEVSRL 615
                R    + H IGF I++VPE    Q    L     L +    R       +EV   
Sbjct: 337 HRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNR 396

Query: 616 CLLPAGTYKVVPSTYLPDTEGAFTVTI 642
             LP G Y +VPST+ P+ +G F + +
Sbjct: 397 FKLPPGEYILVPSTFEPNKDGDFCIRV 423


>gi|10864059 calpain 10 isoform h [Homo sapiens]
          Length = 138

 Score =  186 bits (472), Expect = 6e-47
 Identities = 92/92 (100%), Positives = 92/92 (100%)

Query: 581 QVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTV 640
           QVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTV
Sbjct: 47  QVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTV 106

Query: 641 TIATRIDRPSIHSQEMLGQFLQEVSVMAVMKT 672
           TIATRIDRPSIHSQEMLGQFLQEVSVMAVMKT
Sbjct: 107 TIATRIDRPSIHSQEMLGQFLQEVSVMAVMKT 138



 Score = 99.8 bits (247), Expect = 7e-21
 Identities = 47/47 (100%), Positives = 47/47 (100%)

Query: 1  MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQ 47
          MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQ
Sbjct: 1  MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQ 47



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 20/56 (35%), Positives = 27/56 (48%)

Query: 430 RRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRV 485
           R  + P +L   P+     H Y +EV   C L  G Y  VPST+L D  G F + +
Sbjct: 53  RSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTI 108


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  184 bits (467), Expect = 2e-46
 Identities = 153/498 (30%), Positives = 229/498 (45%), Gaps = 71/498 (14%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF D +FPA  SS+     + L +    + W+RP E+ + P+ +    +   + QG++GD
Sbjct: 43  LFEDTSFPATLSSI--GSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGD 100

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL- 131
           CWFL A  AL   + +L +V+P  Q     ++Y G F    W +G WV V  DDRLP   
Sbjct: 101 CWFLAALQALALHQDILSRVVPLNQSF--TEKYAGIFRFWFWHYGNWVPVVIDDRLPVNE 158

Query: 132 AGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVA 191
           AG+L F     +++FW  LLEK YAK+ GSYE L +GQV++ALVD TGG+    NL    
Sbjct: 159 AGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAH 218

Query: 192 GSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLS-PRAGARELGEFHAFIVSDLRELQG 250
           G+         W+      +    ++ LI C   S  +     L E HA+ ++ +R++  
Sbjct: 219 GN--------LWD----ILIEATYNRTLIGCQTHSGEKILENGLVEGHAYTLTGIRKVTC 266

Query: 251 QAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLR 310
           +  +   L++++NPWG+  W+G W +    W  +       LL +  +GEFW+  ++F  
Sbjct: 267 K-HRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKT 325

Query: 311 EF-----DELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN--NSGFPS 363
            F      +LT G    EA   +  YT R         G W K  +AGG R      F  
Sbjct: 326 HFVLLVICKLTPGLLSQEAAQ-KWTYTMR--------EGRWEKRSTAGGQRQLLQDTFWK 376

Query: 364 NPKFWLRVSEPSE---------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPG 414
           NP+F L V  P E         V +++LQ+ R        R R                 
Sbjct: 377 NPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRC-----RKR----------------- 414

Query: 415 KHYQAVGLHLWKVEK-----RRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAV 469
           K   A+G +L+++ K     RR+         P++       ++EV     L PG YL V
Sbjct: 415 KPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474

Query: 470 PSTFLKDAPGEFLLRVFS 487
           P         EF+LRVFS
Sbjct: 475 PCILEAHQKSEFVLRVFS 492



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 56/189 (29%), Positives = 78/189 (41%), Gaps = 23/189 (12%)

Query: 475 KDAPGEF--LLRVFSTGRVSLSAIRAVAKNTTPG--AALPAGEWGTVQLRGSWRVGQTAG 530
           KD  GEF   L+ F T  V L     V    TPG  +   A +W      G W    TAG
Sbjct: 310 KDNDGEFWMTLQDFKTHFVLL-----VICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAG 364

Query: 531 GSRNFA--SYPTNPCFPFSV--PE----GPGPRCVRITLHQHCRPSDTEFHP---IGFHI 579
           G R     ++  NP F  SV  PE       P  V ++L Q  R    +  P   IGF++
Sbjct: 365 GQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAIGFYL 424

Query: 580 FQVPEGGRSQ-DAPPLLLQEPLLSCVPHRY--AQEVSRLCLLPAGTYKVVPSTYLPDTEG 636
           +++ +    Q   PP   Q       P R+   +EVS+   L  GTY +VP       + 
Sbjct: 425 YRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKS 484

Query: 637 AFTVTIATR 645
            F + + +R
Sbjct: 485 EFVLRVFSR 493


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  180 bits (456), Expect = 4e-45
 Identities = 155/511 (30%), Positives = 222/511 (43%), Gaps = 72/511 (14%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF D  F   + SLF +   P       + W+RPQ+IC  P L   +    Q+ QG LG 
Sbjct: 26  LFCDPTFLPENDSLFYNRLLP-----GKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGH 80

Query: 73  CWFLCA--CAALQKSRHLLDQVIPPGQPSWADQE---YRGSFTCRIWQFGRWVEVTTDDR 127
              + A  C A+Q+S H    +    +  W  Q+   Y G F  R W FG W EV  DD 
Sbjct: 81  KPMVSAFSCLAVQES-HWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDL 139

Query: 128 LPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNL 187
           LP + G L FS     + FW  LLEK YAK+ G YE L    + D +VD TG LAE  ++
Sbjct: 140 LPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDM 199

Query: 188 KGVAGSGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE------LGEFHAF 240
           +      G+       +++   +L        LI C + SP    +E      L + H +
Sbjct: 200 Q-----KGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTY 254

Query: 241 IVSDLRELQ-GQ------AGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASEL- 292
            ++D+R+++ G+      + + + ++R++NP GR+ W G W E  E W Q+ A+    L 
Sbjct: 255 TMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLG 314

Query: 293 LSQLQEGEFWVEEEEFLREFDEL----TVGYPVTEAGHLQSLYTERLLCHTRALPGAWVK 348
           L    +GEFW+  E+F R F +L     V  P+     L+S+             G W  
Sbjct: 315 LVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVL------------GCWTV 362

Query: 349 GQS-----AGGCRNN-SGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGD 402
                   +GGC NN   F  NP++   V E     I  LQ+  L      GR    +  
Sbjct: 363 DDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI-- 420

Query: 403 SHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELS 462
                            +G  L+KVE  R      L +   AGT+ +   R V L   L 
Sbjct: 421 -----------------IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLK 463

Query: 463 PGYYLAVPSTFLKDAPGEFLLRVFSTGRVSL 493
            G Y+ VP+ F      EFLLR+FS   V L
Sbjct: 464 KGNYVLVPTMFQHGRTSEFLLRIFSEVPVQL 494


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  174 bits (442), Expect = 2e-43
 Identities = 141/488 (28%), Positives = 214/488 (43%), Gaps = 81/488 (16%)

Query: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96

Query: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154

Query: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210

Query: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246
                + P  +     + L   K   L+ C + +  A   E      L + HA+ V+ + 
Sbjct: 211 -----EAPENFYEILEKAL---KRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262

Query: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
           ++  + GQ I L+RI+NPWG+  W G W +                          +  +
Sbjct: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296

Query: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
           +F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F +NP
Sbjct: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ----GSWVRGSTAGGCRNFLDTFWTNP 352

Query: 366 KFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQA 419
           +  L ++E  E        +A++Q+ R     +      +       ++    P K  + 
Sbjct: 353 QIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTI------GYAIYECPDKD-EH 405

Query: 420 VGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPG 479
           +    ++    R      +++            REV  R +L PG Y+ +PSTF      
Sbjct: 406 LNKDFFRYHASRARSKTFINL------------REVSDRFKLPPGEYILIPSTFEPHQEA 453

Query: 480 EFLLRVFS 487
           +F LR+FS
Sbjct: 454 DFCLRIFS 461



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/138 (28%), Positives = 56/138 (40%), Gaps = 8/138 (5%)

Query: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV---PEGPGPRCVRITLHQHCRPS 568
           +W     +GSW  G TAGG RNF  ++ TNP    S+    EG       + L Q  R  
Sbjct: 322 KWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRK 381

Query: 569 DTEFH----PIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYK 624
              F      IG+ I++ P+     +                   +EVS    LP G Y 
Sbjct: 382 LKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441

Query: 625 VVPSTYLPDTEGAFTVTI 642
           ++PST+ P  E  F + I
Sbjct: 442 LIPSTFEPHQEADFCLRI 459


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  155 bits (391), Expect = 1e-37
 Identities = 149/501 (29%), Positives = 220/501 (43%), Gaps = 89/501 (17%)

Query: 14  FRDAAFPAADSSLFCDLSTPLAQFR-EDITWRRPQEICATPRLFP-DDPREGQVKQGLLG 71
           F+D  FPAADSS+   L   L + R  ++ W+RPQ++   P  F  DD     ++QG   
Sbjct: 35  FKDETFPAADSSIGQKL---LQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGAA 91

Query: 72  DCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL 131
           DCWFL A  +L ++     +++     S    +Y G F  R WQ G+WVEV  DDRLP  
Sbjct: 92  DCWFLAALGSLTQNPQYRQKILMVQSFS---HQYAGIFRFRFWQCGQWVEVVIDDRLPVQ 148

Query: 132 AGRLCFSRCQREDV-FWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
             +  F R + ++  FW  LLEK YAK+ GSY  L  G + DALVDLTGG+    +L   
Sbjct: 149 GDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHL--- 205

Query: 191 AGSGGQQDRPGRWEHRTCRQLLH-----LKDQCLISCCVLS---PRAGARELG--EFHAF 240
                         H +   L+       K   LI+C   S     A A E G    HA+
Sbjct: 206 --------------HSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAY 251

Query: 241 IVSDLRELQGQAGQCILLLRIQNP--WGRRCWQGLWREGGEGWSQVDAAVASELLSQLQE 298
            V+   ++Q + G    ++ + NP  WG   W+G W +G + W +      S+L  + ++
Sbjct: 252 TVTGAEQIQYRRG-WEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310

Query: 299 GEFWVEEEEFLREFDELTV--GYPVTEAGHLQSLYTERLLCHTRALPGAW---------V 347
           GEFW+  ++F ++F  + +    P+T             L H   L   W         +
Sbjct: 311 GEFWMSCQDFQQKFIAMFICSEIPIT-------------LDHGNTLHEGWSQIMFRKQVI 357

Query: 348 KGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSW 407
            G +AGG RN++      +F   V EP E    V+                 V  S+   
Sbjct: 358 LGNTAGGPRNDA------QFNFSVQEPMEGTNVVV------------CVTVAVTPSNLKA 399

Query: 408 SPASIPGKHYQAVGLHLWKVEKRRVNLPRVL--SMPPVAGTACHAYDREVHLRCELSPGY 465
             A  P   +Q +   L   ++ R   P V   S      ++ + + R   +   LSPG 
Sbjct: 400 EDAKFP-LDFQVI---LAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGN 455

Query: 466 YLAVPSTFLKDAPGEFLLRVF 486
           Y+ V  T  K A  EFLLR+F
Sbjct: 456 YVVVAQTRRKSA--EFLLRIF 474


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  123 bits (309), Expect = 5e-28
 Identities = 102/322 (31%), Positives = 149/322 (46%), Gaps = 38/322 (11%)

Query: 14  FRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP---------REGQ 64
           F D +FP    S+       + Q      W RPQEI  +  +F D           R   
Sbjct: 488 FVDDSFPPGPESVGFPAGDSVQQRVRQ--WLRPQEINCS--VFRDHRATWSVFHTLRPSD 543

Query: 65  VKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTT 124
           + QGLLG+CWFL A A L +   L+++V+             G++  R+ + G W  V  
Sbjct: 544 ILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLC-----AEGAYQVRLCKDGTWTTVLV 598

Query: 125 DDRLPC-LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAE 183
           DD LPC  AG L FS+ QR+ + W+ L+EK  AK+HGSY  L AG+  + L  LTG   E
Sbjct: 599 DDMLPCDEAGCLLFSQAQRKQL-WVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657

Query: 184 RWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLI--SC-----CVLSPRAGARELGE 236
              L+    S   ++ P   +    + L   +   L+  SC      V      +  L  
Sbjct: 658 SLALQ--LSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715

Query: 237 FHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQ- 295
            HA+ + D+R++QG       LLR++NPWGR  W G W    + W      +  EL+   
Sbjct: 716 RHAYSILDVRDVQGTR-----LLRLRNPWGRFSWNGSW---SDEWPHWPGHLRGELMPHG 767

Query: 296 LQEGEFWVEEEEFLREFDELTV 317
             EG FW+E  +F+R FD + +
Sbjct: 768 SSEGVFWMEYGDFVRYFDSVDI 789


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 142/619 (22%), Positives = 238/619 (38%), Gaps = 105/619 (16%)

Query: 43  WRRPQEICATPRLFPDDPREGQVKQGLLGDCWF---LCACAALQK--SRHLLDQVIPPGQ 97
           W RP+++   P +         +KQ ++ DC F   L   AA ++  ++ L+  +I P Q
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYP-Q 318

Query: 98  PSWADQEYR--GSFTCRIWQFGRWVEVTTDDRLPC-LAGRLCFSRCQREDVFWLPLLEKV 154
               + EY   G +  ++   G   +V  DD+LP    G L  S    +   W+ L+EK 
Sbjct: 319 NKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKA 378

Query: 155 YAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHL 214
           Y KV G Y+   +    D L  LTG + ER     +A     Q        R   Q  H 
Sbjct: 379 YMKVMGGYDFPGSNSNID-LHALTGWIPER-----IAMHSDSQTFSKDNSFRMLYQRFHK 432

Query: 215 KDQCLISCCVLSPRAGARELG--EFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQG 272
            D  + +   +   A   + G    HA+ V D+RE +G     +  ++++NPW    W+G
Sbjct: 433 GDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKG-----LRFIQLKNPWSHLRWKG 487

Query: 273 LWREGG-EGWS---QVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQ 328
            + E   + W+   Q           ++  G FW+        +D+L   Y V       
Sbjct: 488 RYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWIS-------WDDLCQYYDVIYLSWNP 540

Query: 329 SLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEP---SEVYIAVLQRS 385
            L+ E    H+      W   Q  G  ++     +NP++ L V  P   + V++ +L R 
Sbjct: 541 GLFKESTCIHS-----TWDAKQ--GPVKDAYSLANNPQYKLEVQCPQGGAAVWV-LLSRH 592

Query: 386 RLHAADWAGRARALV-----GDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSM 440
                D+A     +       D    + PA  P             ++  R+N P  L+ 
Sbjct: 593 ITDKDDFANNREFITMVVYKTDGKKVYYPADPPPY-----------IDGIRINSPHYLTK 641

Query: 441 PPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVA 500
             +     H +                 V S + K     + +RV+S    + S I    
Sbjct: 642 IKLTTPGTHTFT---------------LVVSQYEKQNTIHYTVRVYSACSFTFSKI---- 682

Query: 501 KNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPEGPGPRCVRI 559
                    P+    + ++ G W  GQ+AGG  NF  ++  NP + F + E  GP  + +
Sbjct: 683 ---------PSPYTLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHI-EKTGPLLIEL 731

Query: 560 TLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLP 619
              +         + +GF +  V   G     P   L++   S   +R       L  +P
Sbjct: 732 RGPRQ--------YSVGFEVVTVSTLG--DPGPHGFLRK---SSGDYRCGFCYLELENIP 778

Query: 620 AGTYKVVPSTYLPDTEGAF 638
           +G + ++PST+LP  EG F
Sbjct: 779 SGIFNIIPSTFLPKQEGPF 797


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score = 38.9 bits (89), Expect = 0.016
 Identities = 20/38 (52%), Positives = 23/38 (60%)

Query: 453 REVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGR 490
           REV  R  L P  Y+ VPST+     GEF+LRVFS  R
Sbjct: 29  REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 15/33 (45%), Positives = 20/33 (60%)

Query: 610 QEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTI 642
           +EVS+   LP   Y +VPSTY P  EG F + +
Sbjct: 29  REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRV 61


>gi|239752515 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 479

 Score = 31.6 bits (70), Expect = 2.5
 Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 13/77 (16%)

Query: 502 NTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEG----PGPRCV 557
           NT PG   PA  W      G+W +G  A         P  PC   ++P+G     G R V
Sbjct: 222 NTAPGGCHPAPSWVAFAHTGAWGMGLPA---------PQVPCETGALPQGVFVSQGARAV 272

Query: 558 RITLHQHCRPSDTEFHP 574
            +       P++    P
Sbjct: 273 PVLQPSQATPAEVISQP 289


>gi|90903231 huntingtin [Homo sapiens]
          Length = 3144

 Score = 30.4 bits (67), Expect = 5.5
 Identities = 11/24 (45%), Positives = 15/24 (62%)

Query: 380 AVLQRSRLHAADWAGRARALVGDS 403
           ++L RSR H  DW G  R L G++
Sbjct: 780 SILSRSRFHVGDWMGTIRTLTGNT 803


>gi|239744246 PREDICTED: hypothetical protein XP_002343082 [Homo
           sapiens]
          Length = 483

 Score = 30.4 bits (67), Expect = 5.5
 Identities = 16/50 (32%), Positives = 20/50 (40%), Gaps = 9/50 (18%)

Query: 502 NTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEG 551
           N  PG   PA  W      G+W  G  A         P  PC P ++P+G
Sbjct: 226 NAAPGGGHPAPSWVAFAHTGAWGTGLPA---------PHVPCAPGALPQG 266


>gi|7662350 cell recognition molecule Caspr2 precursor [Homo
           sapiens]
          Length = 1331

 Score = 30.0 bits (66), Expect = 7.2
 Identities = 20/68 (29%), Positives = 31/68 (45%), Gaps = 2/68 (2%)

Query: 343 PGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYI-AVLQRSRLHAADWAGRARALVG 401
           PG + K    GG    S   S+   WL+V   +   I A+  + R  ++DW  + R L  
Sbjct: 60  PG-YAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYS 118

Query: 402 DSHTSWSP 409
           D+  +W P
Sbjct: 119 DTGRNWKP 126


>gi|239757286 PREDICTED: similar to Fc fragment of IgG binding
           protein [Homo sapiens]
          Length = 1472

 Score = 29.6 bits (65), Expect = 9.5
 Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 4/44 (9%)

Query: 93  IPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLC 136
           + PGQ  WAD+  +   TC     G   +VT  D+  C AG  C
Sbjct: 869 LAPGQEVWADELCQRRCTCN----GATHQVTCRDKQSCPAGERC 908


>gi|169213727 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 235

 Score = 29.6 bits (65), Expect = 9.5
 Identities = 25/76 (32%), Positives = 31/76 (40%), Gaps = 9/76 (11%)

Query: 318 GYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCR---------NNSGFPSNPKFW 368
           G  V  A  LQ    E+ LC TRA  G      + GGCR         ++S F S   F 
Sbjct: 57  GGAVGGAAGLQFRRPEKRLCRTRARLGKAPSACAGGGCRRSATSDDAPSSSSFSSRRAFL 116

Query: 369 LRVSEPSEVYIAVLQR 384
           L  S  S   + +L R
Sbjct: 117 LGTSPTSPPSLRLLLR 132


>gi|239753407 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 182

 Score = 29.6 bits (65), Expect = 9.5
 Identities = 16/41 (39%), Positives = 19/41 (46%)

Query: 515 GTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPR 555
           G+   R S R G  AGG+   A  P  P  P   P  PGP+
Sbjct: 80  GSAARRASERAGGRAGGTALRAREPPPPLLPPPSPPQPGPK 120


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,759,160
Number of Sequences: 37866
Number of extensions: 1570316
Number of successful extensions: 3300
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3133
Number of HSP's gapped (non-prelim): 83
length of query: 672
length of database: 18,247,518
effective HSP length: 109
effective length of query: 563
effective length of database: 14,120,124
effective search space: 7949629812
effective search space used: 7949629812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.