Search of human proteins with 4507137

Search of human proteins with 4507137

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                  1001   0.0  
gi|11321640 basic beta 1 syntrophin [Homo sapiens]                    496   e-140
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                     429   e-120
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                         153   4e-37
gi|9507163 syntrophin, gamma 1 [Homo sapiens]                         121   2e-27
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    78   2e-14
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    78   2e-14
gi|148746189 multiple PDZ domain protein [Homo sapiens]                64   3e-10
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    64   4e-10
gi|45827729 scribble isoform b [Homo sapiens]                          62   2e-09
gi|45827731 scribble isoform a [Homo sapiens]                          62   2e-09
gi|11545920 lin-7 homolog B [Homo sapiens]                             61   3e-09
gi|8922944 lin-7 homolog C [Homo sapiens]                              60   4e-09
gi|4759306 lin-7 homolog A [Homo sapiens]                              60   6e-09
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    59   1e-08
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    59   1e-08
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    59   1e-08
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi...    59   1e-08
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           58   2e-08
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           58   2e-08
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    58   2e-08
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    58   2e-08
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    58   2e-08
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       57   3e-08
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       57   3e-08
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    57   4e-08
gi|112382257 InaD-like [Homo sapiens]                                  57   5e-08
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    57   5e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      57   5e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       57   5e-08

>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score = 1001 bits (2588), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQE 60
           MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQE
Sbjct: 1   MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQE 60

Query: 61  PAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKG 120
           PAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKG
Sbjct: 61  PAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKG 120

Query: 121 LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNST 180
           LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNST
Sbjct: 121 LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNST 180

Query: 181 GGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICS 240
           GGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICS
Sbjct: 181 GGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICS 240

Query: 241 ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL 300
           ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL
Sbjct: 241 ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL 300

Query: 301 TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPY 360
           TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPY
Sbjct: 301 TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPY 360

Query: 361 DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRP 420
           DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRP
Sbjct: 361 DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRP 420

Query: 421 CSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH 480
           CSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH
Sbjct: 421 CSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH 480

Query: 481 SCPKTIVFIIHSFLSAKVTRLGLLA 505
           SCPKTIVFIIHSFLSAKVTRLGLLA
Sbjct: 481 SCPKTIVFIIHSFLSAKVTRLGLLA 505


>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score =  496 bits (1277), Expect = e-140
 Identities = 269/532 (50%), Positives = 355/532 (66%), Gaps = 36/532 (6%)

Query: 2   ASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEP-GAPREQE 60
           A G RA R+GLLE+          +RW +VL++L+ED L +S  +G       G      
Sbjct: 15  AGGGRAQRSGLLEVLVR-------DRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGS 67

Query: 61  PAQLNGAAEPGAG------------------PPQLPEALLLQRRRVTVRKADAGGLGISI 102
             +  GA  PGAG                  P Q+PE++  Q+R V V K + GGLGISI
Sbjct: 68  FCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISI 127

Query: 103 KGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEV 162
           KGG+ENKMPILISKIFKGLAADQT+AL+VGDAILSVNG DL  ATHDEAVQ LK+ GKEV
Sbjct: 128 KGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEV 187

Query: 163 VLEVKYMKDVSPYFKNSTGGTSVGWDS-PPASPLQRQPSSPGPTPRNFS---EAKHMSLK 218
           +LEVKYM++ +PY K  +  + +GW++ PP SP     +S  P+ ++FS   + K + LK
Sbjct: 188 LLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLK 247

Query: 219 MAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDE 278
           M YV++     DPE R LEI S D + T+ LR+KD A+A++W +AI + VN L  RV  E
Sbjct: 248 MCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAE 307

Query: 279 LQALLAATSTAGSQDIKQIGWLTEQLPSGGT---APTLALLTEKELLLYLSLPETREALS 335
           ++  L  T  AGS++I+ +GWL E++P        P L +LTEK+LL+Y S+P  +EA  
Sbjct: 308 VREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWF 367

Query: 336 RPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQ 395
            P  T PL+ATRLVHSGP KGS     +LSFA RTGTR G++THLF  E+ ++L+ WTR 
Sbjct: 368 SPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRS 427

Query: 396 LVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEP--GAARAVLLRQPFEKL 453
           +V GCH +AE + E+STACT+  + C L++H + GF++   EP  GA    +++ P+EKL
Sbjct: 428 IVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSI-TTEPQEGAFPKTIIQSPYEKL 486

Query: 454 QMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA 505
           +MSSDDG  +L+LDFGG +GEIQLDLHSCPK IVFIIHSFLSAK+TRLGL+A
Sbjct: 487 KMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA 538


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score =  429 bits (1102), Expect = e-120
 Identities = 251/541 (46%), Positives = 336/541 (62%), Gaps = 54/541 (9%)

Query: 1   MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVS----------------- 43
           MA   RA + GL+EL          ERW RV+  L+ + L+++                 
Sbjct: 16  MAVWTRATKAGLVELLLR-------ERWVRVVAELSGESLSLTGDAAAAELEPALGPAAA 68

Query: 44  -----PADGDPGPE-PGAPRE-----QEPAQLNG-AAEPGAGPPQLPEALLLQRRRVTVR 91
                P  G  G   PG+P         PA   G A E GA PP          RRV V 
Sbjct: 69  AFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPV---------RRVRVV 119

Query: 92  KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           K +AGGLGISIKGGREN+MPILISKIF GLAADQ+ AL +GDAILSVNG DL  ATHD+A
Sbjct: 120 KQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179

Query: 152 VQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWD--SPPASPLQRQPSSPGPTPRNF 209
           VQ LK+ GKEV+LEVK++++V+PY K  +  + + W+  +P +        S  P  +N 
Sbjct: 180 VQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNS 239

Query: 210 S-EAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQV 268
           + + K + LKM + ++  +  D E R +E+ S D ++TL LR KD A+A SW  AI   +
Sbjct: 240 TKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNI 299

Query: 269 NTLTPRVKDELQALLAATSTA-GSQDIKQIGWLTEQLPSGG----TAPTLALLTEKELLL 323
             L P+V  EL A+L ATSTA GS+++K I WL EQ    G      P L  +TEK+LLL
Sbjct: 300 MALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLL 359

Query: 324 YLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSV 383
           Y  +P TR+A + P  + PL+ATRLVHSG    S    ++L+FA RTG+R G++ HLF V
Sbjct: 360 YDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRV 419

Query: 384 ESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARA 443
           E+ ++L++WTR LV GCH AAE ++EVS  C  NG+   L++H + GFT+ + E G + +
Sbjct: 420 ETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTI-SRENGGSSS 478

Query: 444 VLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGL 503
           +L R PFE+L+MS+DDG   L+LDFGG EGE+ +DLHSCPK IVF++H+FLSAKVTR+GL
Sbjct: 479 ILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGL 538

Query: 504 L 504
           L
Sbjct: 539 L 539


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score =  153 bits (386), Expect = 4e-37
 Identities = 133/460 (28%), Positives = 204/460 (44%), Gaps = 58/460 (12%)

Query: 85  RRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLS 144
           RR VT+R+   GGLG+SIKGG E+ +P++ISKIF+  AADQT  LFVGDA+L VNG  + 
Sbjct: 71  RRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVE 130

Query: 145 SATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTG--GTSVGWDSPPASPL------- 195
           +ATH+E V +L+  G EV + V+Y+++   + K   G  G S    S  +SPL       
Sbjct: 131 NATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHL 190

Query: 196 --------QRQPSSP-GPTPR---NFSEAKHMSLKMAYVSK-RCTPNDPEPRYLEICSAD 242
                      PSSP    PR    + +   + L MA +S+ +           E+ + D
Sbjct: 191 NGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALD 250

Query: 243 GQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQD-IKQIGWLT 301
           G  +  LR         W  A+ A +  LT      LQ +  A       D +  +GW+ 
Sbjct: 251 GVSSGILRFYTAQDGTDWLRAVSANIRELT------LQNMKMANKCCSPSDQVVHMGWVN 304

Query: 302 EQLPSGGTA----PTLALLTEKELLLYLSLPETREALSRPARTAPLIATRL--------- 348
           E+L    ++    P    L      ++ + P +     R  RT  L              
Sbjct: 305 EKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTE 364

Query: 349 ---VHSGPSKGSVPYDAE----LSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCH 401
              + +    G   +D E      F++  G  HG  +H+F+VE   ELA W +       
Sbjct: 365 DCWLQANLYLGLQDFDFEDQRPYCFSIVAG--HG-KSHVFNVELGSELAMWEKSFQRATF 421

Query: 402 RAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDG- 460
              +     +  C+W G     +V    GFT + ++    + VL R  F +L+ SSDDG 
Sbjct: 422 MEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESK---TKNVLWRFKFSQLKGSSDDGK 478

Query: 461 --ASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKV 498
               LLF +    + E++       + ++  IHSF++AKV
Sbjct: 479 TRVKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518


>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
          Length = 517

 Score =  121 bits (303), Expect = 2e-27
 Identities = 122/450 (27%), Positives = 190/450 (42%), Gaps = 49/450 (10%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R VT+R+   GG G+SIKGG E+ +P+++SKI K   A+ +  LF+GDAIL +NG ++  
Sbjct: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFK-------------NSTGGTSVGWDS--- 189
             H+E VQVL+  G+EV L V ++K    + K              S+G +S   DS   
Sbjct: 116 CRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLH 175

Query: 190 -------PPASPLQRQPSSPG-PTPRNFSEAKHMSLKMAYVSKRCTPND-PEPRYLEICS 240
                           P+SPG    + + + + + L  +  S+     D       ++ +
Sbjct: 176 LNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIA 235

Query: 241 ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL 300
            DG  T  ++         W  AI   ++ LT     ++           +Q I  +GW 
Sbjct: 236 VDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPV-----NQQIVYMGWC 290

Query: 301 ----TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPL--IATRLVHSGPS 354
                + L     +PT   L    L  +L+ P T    +R  +T  +  I  +++     
Sbjct: 291 EAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKIL----- 345

Query: 355 KGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTAC 414
           K S   D          +  G D + FSVE   +LA W R          E +Q  + AC
Sbjct: 346 KDSDLLDRRKQ-CFTVQSESGEDLY-FSVELESDLAQWERAFQTATFLEVERIQCKTYAC 403

Query: 415 TWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGAS---LLFLDFGGA 471
                   L++    GF  + A   A +AVL R  F +L+ SSDDG S    LF +    
Sbjct: 404 VLESHLMGLTIDFSTGFICFDA---ATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTK 460

Query: 472 EGEIQLDLHSCPKTIVFIIHSFLSAKVTRL 501
           + E +    S    ++  IHSF +AKV  L
Sbjct: 461 QIEAKELEFSNLFAVLHCIHSFFAAKVACL 490


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 42/84 (50%), Positives = 55/84 (65%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + K D  GLGISI GG+E+ +PILIS+I  G  AD+   L VGDAIL+VNG +L  
Sbjct: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYM 169
             H EAV +L +   E+  EV Y+
Sbjct: 347 TKHKEAVTILSQQRGEIEFEVVYV 370


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 42/84 (50%), Positives = 55/84 (65%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + K D  GLGISI GG+E+ +PILIS+I  G  AD+   L VGDAIL+VNG +L  
Sbjct: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYM 169
             H EAV +L +   E+  EV Y+
Sbjct: 339 TKHKEAVTILSQQRGEIEFEVVYV 362


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 54/164 (32%), Positives = 79/164 (48%), Gaps = 27/164 (16%)

Query: 17   AGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEP--GAPREQEPAQLNGAAEPGAGP 74
            AGA SG      Q +++          P  G P PE      R   PA    A++P   P
Sbjct: 1574 AGAASGEKKNSSQSLMV----------PQSGSPEPESIRNTSRSSTPAIF--ASDPATCP 1621

Query: 75   --PQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKM-PILISKIFKGLAADQTEALFV 131
              P     + + + R         GLG+SI GG +  +  I+I ++++  AA +   L+ 
Sbjct: 1622 IIPGCETTIEISKGRT--------GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWA 1673

Query: 132  GDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPY 175
            GD IL VNG DL  ATHDEA+ VL++T + V L +   +D +PY
Sbjct: 1674 GDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL--YRDEAPY 1715



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 37/97 (38%), Positives = 51/97 (52%), Gaps = 12/97 (12%)

Query: 73   GPPQLPEALLLQRRRVTVRKADAGGLGISIKGGR---ENKMPILISKIFKGLAADQTEAL 129
            GPPQ  +++ L+R           GLG SI GG       +PI +  +F   AA +   L
Sbjct: 1952 GPPQC-KSITLER--------GPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRL 2002

Query: 130  FVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
              GD I++VNG+ L   TH+EAV +LK+T   V L V
Sbjct: 2003 KRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 9/93 (9%)

Query: 84   QRRRVTVRKADAGGLGISIKGGR---------ENKMPILISKIFKGLAADQTEALFVGDA 134
            Q RRV + +  +  LGISI GGR         E    I I  + +   A +   L  GD 
Sbjct: 1148 QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDR 1207

Query: 135  ILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVK 167
            I+ V+G DL  A+H++AV+ ++K G  VV  V+
Sbjct: 1208 IVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 3/91 (3%)

Query: 86   RRVTVRKADAGGLGISIKGGRENKM---PILISKIFKGLAADQTEALFVGDAILSVNGED 142
            R V ++K     LGISI GG  + +   PI I+ +     A QT+ L VGD I+++ G  
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891

Query: 143  LSSATHDEAVQVLKKTGKEVVLEVKYMKDVS 173
                TH +AV +LK     + ++V    DVS
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVS 1922



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 29/69 (42%), Positives = 39/69 (56%), Gaps = 1/69 (1%)

Query: 88   VTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSAT 147
            + ++K    GLG+SI G R N   + +S I KG  AD    L  GD IL VNGED+ +AT
Sbjct: 1726 IELQKKPGKGLGLSIVGKR-NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784

Query: 148  HDEAVQVLK 156
             +    +LK
Sbjct: 1785 QEAVAALLK 1793



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 4/72 (5%)

Query: 97  GLGISIKG--GRENKMP--ILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAV 152
           GLGI+I G  G +   P  I +  I K  A +    + +GD I++V+G +L   T+ +AV
Sbjct: 386 GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAV 445

Query: 153 QVLKKTGKEVVL 164
           +VL+ TG+ V+L
Sbjct: 446 EVLRHTGQTVLL 457



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 94  DAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQ 153
           D  GLG  I GG+     +++  I  G  ADQ   L  GD IL +   DL+  + ++  Q
Sbjct: 263 DGSGLGFGIIGGKATG--VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320

Query: 154 VLKKTGKEVVLEV 166
           VL++ G  V L +
Sbjct: 321 VLRQCGNRVKLMI 333



 Score = 36.2 bits (82), Expect = 0.072
 Identities = 19/61 (31%), Positives = 34/61 (55%), Gaps = 1/61 (1%)

Query: 97   GLGISIKGGRE-NKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVL 155
            GLG+S+ G ++ ++M + I  I    AA +   L + D +L +NG+ L   +H  A  ++
Sbjct: 1359 GLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSII 1418

Query: 156  K 156
            K
Sbjct: 1419 K 1419



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 18/72 (25%), Positives = 40/72 (55%), Gaps = 2/72 (2%)

Query: 86   RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
            R + + K ++  LG+++   ++  + +++  I  G A  +   + +GD ILS+N E   S
Sbjct: 1007 RTINIAKGNSS-LGMTVSANKDG-LGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064

Query: 146  ATHDEAVQVLKK 157
             T+ +A  +L++
Sbjct: 1065 VTNAQARAMLRR 1076



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)

Query: 33  LSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRK 92
           L L +  LT  P   D G   G+   ++P      A       Q P A+     +    +
Sbjct: 646 LDLCDIELTEKP-HVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELE 704

Query: 93  ADAGGLGISIKGGRENKMP----ILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATH 148
             + GLG SI   ++   P    I+I  +  G  A++   L  GD ++ VN  +L +++ 
Sbjct: 705 KGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSL 764

Query: 149 DEAVQVLK 156
           +EAV+ LK
Sbjct: 765 EEAVEALK 772



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 21/72 (29%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 93  ADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAV 152
           ++  GLGIS++    +     I  +        +  LF GD +L VNG  L    H + V
Sbjct: 560 SENSGLGISLEATVGHHF---IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVV 616

Query: 153 QVLKKTGKEVVL 164
            +LK+   EV +
Sbjct: 617 NILKELPIEVTM 628


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 10/161 (6%)

Query: 9   RTGLLELRAGAGSG-AGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGA 67
           R G  + R   GS  A GE    +L  L+ +    +P + D GP     ++   A ++ A
Sbjct: 75  RGGRAKQRGSRGSWWAAGETIANMLCGLSRE----TPGEADDGPYSKGGKDAGGADVSLA 130

Query: 68  AEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTE 127
               + P +     +++     + K +   LG++I GG +      +S +  G  A +++
Sbjct: 131 CRRQSIPEEFRGITVVE-----LIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD 185

Query: 128 ALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKY 168
            L +GD I SVNG  L+   HDE + +LK  G+ VVLEV+Y
Sbjct: 186 LLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEY 226



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/107 (35%), Positives = 54/107 (50%), Gaps = 3/107 (2%)

Query: 92  KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           K   G LGI+I G  E   PI+IS + K   A++T A+ VGD IL++N   L      EA
Sbjct: 758 KRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEA 817

Query: 152 VQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTS--VGWDSPPASPLQ 196
           + +L+  G+ V L++K   D  P     +G  S     D  PA  L+
Sbjct: 818 IHLLQVAGETVTLKIKKQLD-RPLLPRKSGSLSETSDADEDPADALK 863



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 35/129 (27%), Positives = 61/129 (47%), Gaps = 8/129 (6%)

Query: 74  PPQLPE---ALLLQRRRVTVRKADAGGLGISIKGGREN----KMPILISKIFKGLAADQT 126
           PP  PE    ++ +   V++ K +    G  ++GG         P++++ +  G  AD+ 
Sbjct: 229 PPPAPENNPRIISKTVDVSLYK-EGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADRE 287

Query: 127 EALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVG 186
            +L VGD +LSV+G  L  A+H  A+  L++   E + +V+Y         N++G   V 
Sbjct: 288 GSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVE 347

Query: 187 WDSPPASPL 195
               P S L
Sbjct: 348 IVKTPGSAL 356



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 29/88 (32%), Positives = 50/88 (56%), Gaps = 2/88 (2%)

Query: 98  LGISIKGG-RENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           LGI+I    R+   P++IS I KG  A +T  L  GD +L+++   L +   ++AVQ+L+
Sbjct: 666 LGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725

Query: 157 KTGKEVVLEVKYMKDVSPYFKNSTGGTS 184
           +    V L+++  +D S   + +TG  S
Sbjct: 726 QCEDLVKLKIRKDEDNSDELE-TTGAVS 752



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 26/80 (32%), Positives = 40/80 (50%), Gaps = 1/80 (1%)

Query: 88  VTVRKADAGGLGISIKG-GRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSA 146
           V + K     LGIS+      NK  I I +I      D++ AL  GD ILS++G  +   
Sbjct: 346 VEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405

Query: 147 THDEAVQVLKKTGKEVVLEV 166
           +  EA ++L    ++V LE+
Sbjct: 406 SLLEATKLLASISEKVRLEI 425



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 6/78 (7%)

Query: 97  GLGISIKGG----RENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAV 152
           G G+ ++GG         P L+  I     A++   L VGD +LS+NG      T +EA 
Sbjct: 564 GFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEAN 623

Query: 153 QVLKKT--GKEVVLEVKY 168
           Q+L+      +VVLEV++
Sbjct: 624 QLLRDAALAHKVVLEVEF 641


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 48/158 (30%), Positives = 74/158 (46%), Gaps = 16/158 (10%)

Query: 13  LELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGA 72
           +E   GAG+      W+  ++   E+ +T++P   +   +  +PRE+      G      
Sbjct: 797 VEALRGAGTAVQMRVWRERMVE-PENAVTITPLRPE---DDYSPRERR----GGGLRLPL 848

Query: 73  GPPQLPEALLLQRRRVTVRKADAGGLGISIKGG------RENKMPILISKIFKGLAADQT 126
            PP+ P  L  ++R V        GLG SI GG      R     I +S+I +G AA + 
Sbjct: 849 LPPESPGPL--RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRA 906

Query: 127 EALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVL 164
             L VGD +LS+NG D++ A HD AV +L      + L
Sbjct: 907 GTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 51/147 (34%), Positives = 67/147 (45%), Gaps = 20/147 (13%)

Query: 44   PADGDPGPEPGAPREQEPAQLNGAAEPGA-GPPQLPEALLLQRRR-----VTVRKADAGG 97
            P    P P    P           A PG  G P L  +LL            +R   AGG
Sbjct: 953  PLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012

Query: 98   -LGISIKGGRENKMP--------ILISKIF-KGLAADQTEALFVGDAILSVNGEDLSSAT 147
             LG+SI GG ++           + ISK+  +GLAA     L VGD IL+VNG+D+  AT
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA--RSGLRVGDRILAVNGQDVRDAT 1070

Query: 148  HDEAVQVLKKTGKEVVLEVKYMKDVSP 174
            H EAV  L +   E+ L V+  +D +P
Sbjct: 1071 HQEAVSALLRPCLELSLLVR--RDPAP 1095



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 113/420 (26%), Positives = 158/420 (37%), Gaps = 90/420 (21%)

Query: 96   GGLGISIKGGRENKM------PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHD 149
            GGLGISI GG+ +         I IS++ +   A +   + VGD +L VNG  L  A H 
Sbjct: 736  GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDKLLEVNGVALQGAEHH 794

Query: 150  EAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQ----------P 199
            EAV+ L+  G  V + V   + V P  +N+   T +       SP +R+          P
Sbjct: 795  EAVEALRGAGTAVQMRVWRERMVEP--ENAVTITPLR-PEDDYSPRERRGGGLRLPLLPP 851

Query: 200  SSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARS 259
             SPGP            L+  +V+  C       R L    A G+ +   RA D     S
Sbjct: 852  ESPGP------------LRQRHVA--CLAR--SERGLGFSIAGGKGSTPYRAGDAGIFVS 895

Query: 260  WATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEK 319
                  A     T +V D + ++     T    D   +  LT        +PT+ALL E+
Sbjct: 896  RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD-HAVSLLT------AASPTIALLLER 948

Query: 320  EL---LLYLSLPETREALSRPARTAPLIATRLVHSGPSKG--------SVPYDAE----- 363
            E    L    LP +    +  A T+   AT  V   PS            PY  E     
Sbjct: 949  EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008

Query: 364  -----LSFALRTGTRHGVDTHLFSVES---------PQELAAWTRQLVDGCHRAAEGVQE 409
                 L  ++  G+ H   +H F V+          P+ LAA +   V     A  G Q+
Sbjct: 1009 RAGGPLGLSIVGGSDH--SSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG-QD 1065

Query: 410  VSTACTWNG-----RPC---SLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGA 461
            V  A          RPC   SL V  D       A PG     + + P E+L +S   GA
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRD------PAPPGLRELCIQKAPGERLGISIRGGA 1119



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 37/108 (34%), Positives = 52/108 (48%), Gaps = 16/108 (14%)

Query: 75   PQLPEALLLQR-------RRVTVRKADAGGLGISIKGGRENKMP---------ILISKIF 118
            P L  +LL++R       R + ++KA    LGISI+GG               I ISK+ 
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140

Query: 119  KGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
               AA +   L VG  +L VN + L   TH EAVQ+L+  G  + + V
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 48/158 (30%), Positives = 74/158 (46%), Gaps = 16/158 (10%)

Query: 13  LELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGA 72
           +E   GAG+      W+  ++   E+ +T++P   +   +  +PRE+      G      
Sbjct: 797 VEALRGAGTAVQMRVWRERMVE-PENAVTITPLRPE---DDYSPRERR----GGGLRLPL 848

Query: 73  GPPQLPEALLLQRRRVTVRKADAGGLGISIKGG------RENKMPILISKIFKGLAADQT 126
            PP+ P  L  ++R V        GLG SI GG      R     I +S+I +G AA + 
Sbjct: 849 LPPESPGPL--RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRA 906

Query: 127 EALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVL 164
             L VGD +LS+NG D++ A HD AV +L      + L
Sbjct: 907 GTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 51/147 (34%), Positives = 67/147 (45%), Gaps = 20/147 (13%)

Query: 44   PADGDPGPEPGAPREQEPAQLNGAAEPGA-GPPQLPEALLLQRRR-----VTVRKADAGG 97
            P    P P    P           A PG  G P L  +LL            +R   AGG
Sbjct: 953  PLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012

Query: 98   -LGISIKGGRENKMP--------ILISKIF-KGLAADQTEALFVGDAILSVNGEDLSSAT 147
             LG+SI GG ++           + ISK+  +GLAA     L VGD IL+VNG+D+  AT
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA--RSGLRVGDRILAVNGQDVRDAT 1070

Query: 148  HDEAVQVLKKTGKEVVLEVKYMKDVSP 174
            H EAV  L +   E+ L V+  +D +P
Sbjct: 1071 HQEAVSALLRPCLELSLLVR--RDPAP 1095



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 113/420 (26%), Positives = 158/420 (37%), Gaps = 90/420 (21%)

Query: 96   GGLGISIKGGRENKM------PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHD 149
            GGLGISI GG+ +         I IS++ +   A +   + VGD +L VNG  L  A H 
Sbjct: 736  GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDKLLEVNGVALQGAEHH 794

Query: 150  EAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQ----------P 199
            EAV+ L+  G  V + V   + V P  +N+   T +       SP +R+          P
Sbjct: 795  EAVEALRGAGTAVQMRVWRERMVEP--ENAVTITPLR-PEDDYSPRERRGGGLRLPLLPP 851

Query: 200  SSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARS 259
             SPGP            L+  +V+  C       R L    A G+ +   RA D     S
Sbjct: 852  ESPGP------------LRQRHVA--CLAR--SERGLGFSIAGGKGSTPYRAGDAGIFVS 895

Query: 260  WATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEK 319
                  A     T +V D + ++     T    D   +  LT        +PT+ALL E+
Sbjct: 896  RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD-HAVSLLT------AASPTIALLLER 948

Query: 320  EL---LLYLSLPETREALSRPARTAPLIATRLVHSGPSKG--------SVPYDAE----- 363
            E    L    LP +    +  A T+   AT  V   PS            PY  E     
Sbjct: 949  EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008

Query: 364  -----LSFALRTGTRHGVDTHLFSVES---------PQELAAWTRQLVDGCHRAAEGVQE 409
                 L  ++  G+ H   +H F V+          P+ LAA +   V     A  G Q+
Sbjct: 1009 RAGGPLGLSIVGGSDH--SSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG-QD 1065

Query: 410  VSTACTWNG-----RPC---SLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGA 461
            V  A          RPC   SL V  D       A PG     + + P E+L +S   GA
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRD------PAPPGLRELCIQKAPGERLGISIRGGA 1119



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 37/108 (34%), Positives = 52/108 (48%), Gaps = 16/108 (14%)

Query: 75   PQLPEALLLQR-------RRVTVRKADAGGLGISIKGGRENKMP---------ILISKIF 118
            P L  +LL++R       R + ++KA    LGISI+GG               I ISK+ 
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140

Query: 119  KGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
               AA +   L VG  +L VN + L   TH EAVQ+L+  G  + + V
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 1/83 (1%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R V + K D G LG +I GG+E   PI IS++  G  AD+   L  GD +LSVNG  +  
Sbjct: 92  RVVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150

Query: 146 ATHDEAVQVLKKTGKEVVLEVKY 168
             H++AV++LK     V L V+Y
Sbjct: 151 EQHEKAVELLKAAQGSVKLVVRY 173


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 33/76 (43%), Positives = 45/76 (59%)

Query: 97  GLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           GLG +I GG+E   PI IS+I  G  AD+   L  GD +LSVNG  +    H++AV++LK
Sbjct: 102 GLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 161

Query: 157 KTGKEVVLEVKYMKDV 172
               +V L V+Y   V
Sbjct: 162 AAQGKVKLVVRYTPKV 177


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 35/87 (40%), Positives = 49/87 (56%), Gaps = 1/87 (1%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R V + K D G LG ++ GG+E   PI IS+I  G  A++   L  GD +LSVNG  +  
Sbjct: 107 RVVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYMKDV 172
             H++AV++LK     V L V+Y   V
Sbjct: 166 EHHEKAVELLKAAKDSVKLVVRYTPKV 192


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 31/80 (38%), Positives = 46/80 (57%)

Query: 92  KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           K   G LGI+I G  E   PI+IS + KG  A++T A+ +GD IL++N   L      EA
Sbjct: 625 KRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEA 684

Query: 152 VQVLKKTGKEVVLEVKYMKD 171
           + +L+  G+ V L++K   D
Sbjct: 685 IHLLQMAGETVTLKIKKQTD 704



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 30/81 (37%), Positives = 49/81 (60%)

Query: 88  VTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSAT 147
           V + K +   LG+++ GG +      +S + +G  A +++ L VGD I +VNG +L+   
Sbjct: 54  VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFR 113

Query: 148 HDEAVQVLKKTGKEVVLEVKY 168
           HDE + +LK  G+ VVLEV+Y
Sbjct: 114 HDEIISLLKNVGERVVLEVEY 134



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)

Query: 80  ALLLQRRRVTVRKADAGGLGISIKGG----RENKMPILISKIFKGLAADQTEALFVGDAI 135
           +++ +   VT+ K +    G  I+GG    R    P++I+ +  G  AD+   +  GD +
Sbjct: 145 SVIFRTVEVTLHK-EGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRL 203

Query: 136 LSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPL 195
           LSV+G  L   TH EA+ +LK+ G+E  L ++Y   V      ++G   V     P + L
Sbjct: 204 LSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASL 263



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/80 (38%), Positives = 41/80 (51%), Gaps = 1/80 (1%)

Query: 88  VTVRKADAGGLGISIKGGRE-NKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSA 146
           V V K     LG+++      NK  I+I KI     AD+  AL VGD ILS++G  +   
Sbjct: 253 VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYC 312

Query: 147 THDEAVQVLKKTGKEVVLEV 166
           T  EA Q L  T  +V LE+
Sbjct: 313 TLAEATQFLANTTDQVKLEI 332



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 25/77 (32%), Positives = 46/77 (59%)

Query: 97  GLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           G+ IS    R+   P++IS I KG  A +T  L +GD +L+++   L + + ++AVQ+L+
Sbjct: 533 GITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQ 592

Query: 157 KTGKEVVLEVKYMKDVS 173
           +    V L+++  +D S
Sbjct: 593 QCEDLVKLKIRKDEDNS 609



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 16/120 (13%)

Query: 97  GLGISIKGG----RENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAV 152
           G GI ++G          P LIS I     A++   L +GD ++++NG     +T +EA 
Sbjct: 430 GFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEAS 489

Query: 153 QVLKKTG--KEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPP--------ASPLQRQPSSP 202
           Q+L+ +    +V LE+++  DV+     S+G   V              +SP  R+P  P
Sbjct: 490 QLLRDSSITSKVTLEIEF--DVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDP 547


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 40/116 (34%), Positives = 59/116 (50%), Gaps = 6/116 (5%)

Query: 53  PGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPI 112
           P A     P + +  A+   G   +P     + RR+ + +   G LG +I GG + +  I
Sbjct: 326 PTAMTPTSPRRYSPVAKDLLGEEDIPR----EPRRIVIHRGSTG-LGFNIVGGEDGE-GI 379

Query: 113 LISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKY 168
            IS I  G  AD +  L  GD ILSVNG DL +A+H++A   LK  G+ V +  +Y
Sbjct: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 435



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 6/93 (6%)

Query: 83  LQRRRVTVRKADAGGLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILS 137
           ++   +T+ + ++G LG SI GG +N        I I+KI  G AA Q   L V D+IL 
Sbjct: 104 MEYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162

Query: 138 VNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMK 170
           VN  D+   TH  AV+ LK+ G  V L V   K
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 195



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 5/75 (6%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI +G AA +   L +GD IL+VN   L    H++A
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 152 VQVLKKTGKEVVLEV 166
           V  LK T   V L+V
Sbjct: 272 VAALKNTYDVVYLKV 286


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 40/116 (34%), Positives = 59/116 (50%), Gaps = 6/116 (5%)

Query: 53  PGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPI 112
           P A     P + +  A+   G   +P     + RR+ + +   G LG +I GG + +  I
Sbjct: 280 PTAMTPTSPRRYSPVAKDLLGEEDIPR----EPRRIVIHRGSTG-LGFNIVGGEDGE-GI 333

Query: 113 LISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKY 168
            IS I  G  AD +  L  GD ILSVNG DL +A+H++A   LK  G+ V +  +Y
Sbjct: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 389



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 6/93 (6%)

Query: 83  LQRRRVTVRKADAGGLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILS 137
           ++   +T+ + ++G LG SI GG +N        I I+KI  G AA Q   L V D+IL 
Sbjct: 58  MEYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116

Query: 138 VNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMK 170
           VN  D+   TH  AV+ LK+ G  V L V   K
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 149



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 5/75 (6%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI +G AA +   L +GD IL+VN   L    H++A
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 152 VQVLKKTGKEVVLEV 166
           V  LK T   V L+V
Sbjct: 226 VAALKNTYDVVYLKV 240


>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
           sapiens]
          Length = 907

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/127 (33%), Positives = 65/127 (51%), Gaps = 12/127 (9%)

Query: 41  TVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGI 100
           ++SP  G P P  GA R+QE  + +       G            ++V +   D   LG+
Sbjct: 243 SISPPSGLPQPHGGALRQQEGDRRSTLHLLQGG----------DEKKVNLVLGDGRSLGL 292

Query: 101 SIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGK 160
           +I+GG E  + I I+ +  G  A+ +  L VGD IL VNG    +  HDEAV++L K+ +
Sbjct: 293 TIRGGAEYGLGIYITGVDPGSEAEGS-GLKVGDQILEVNGRSFLNILHDEAVRLL-KSSR 350

Query: 161 EVVLEVK 167
            ++L VK
Sbjct: 351 HLILTVK 357



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 38/82 (46%), Positives = 54/82 (65%), Gaps = 3/82 (3%)

Query: 86  RRVTVRKADAG-GLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLS 144
           R V++R+A A  GLG SI+GG E+ + I +S +  G  A++ E L VGD IL VN + L+
Sbjct: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILRVNDKSLA 197

Query: 145 SATHDEAVQVLKKTGKEVVLEV 166
             TH EAV+ LK + K++VL V
Sbjct: 198 RVTHAEAVKALKGS-KKLVLSV 218



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 36/107 (33%), Positives = 50/107 (46%), Gaps = 13/107 (12%)

Query: 56  PREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVR-KADAGGLGISIKGGRENKMPI-L 113
           PR + P   +GA +P           LL+     VR K  A  LGI+I+GG   + P+  
Sbjct: 794 PRNERPT--DGANKPPG---------LLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPR 842

Query: 114 ISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGK 160
           I  I +G +A     L VG  IL VNG  L    H EA +++ +  K
Sbjct: 843 IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFK 889


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/91 (42%), Positives = 50/91 (54%), Gaps = 6/91 (6%)

Query: 88  VTVRKADAGGLGISIKGGREN-----KMPILISKIFKGLAADQTEALFVGDAILSVNGED 142
           +T+ + ++G LG SI GG +N        I I+KI  G AA Q   L V D IL VN  D
Sbjct: 225 ITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 143 LSSATHDEAVQVLKKTGKEVVLEVKYMKDVS 173
           +   TH +AV+ LK+ G  V L VK  K VS
Sbjct: 284 VRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 43/117 (36%), Positives = 59/117 (50%), Gaps = 11/117 (9%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI +G AA +   L +GD +L+VN   L   TH+EA
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 152 VQVLKKTGKEVVLEV-----KYMKD-VSPYFKNSTGGTSVGWDSPPASPLQRQPSSP 202
           V  LK T   V L+V      YM D  +P    ++    V     P+S L + P+SP
Sbjct: 388 VTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASP 444



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + +   G LG +I GG + +  I IS I  G  AD +  L  GD I+SVN  DL +
Sbjct: 465 RKVVLHRGSTG-LGFNIVGGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522

Query: 146 ATHDEAVQVLKKTGKEVVLEVKY 168
           A+H++A   LK  G+ V +  +Y
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQY 545


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/91 (42%), Positives = 50/91 (54%), Gaps = 6/91 (6%)

Query: 88  VTVRKADAGGLGISIKGGREN-----KMPILISKIFKGLAADQTEALFVGDAILSVNGED 142
           +T+ + ++G LG SI GG +N        I I+KI  G AA Q   L V D IL VN  D
Sbjct: 225 ITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 143 LSSATHDEAVQVLKKTGKEVVLEVKYMKDVS 173
           +   TH +AV+ LK+ G  V L VK  K VS
Sbjct: 284 VRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 43/117 (36%), Positives = 59/117 (50%), Gaps = 11/117 (9%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI +G AA +   L +GD +L+VN   L   TH+EA
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 152 VQVLKKTGKEVVLEV-----KYMKD-VSPYFKNSTGGTSVGWDSPPASPLQRQPSSP 202
           V  LK T   V L+V      YM D  +P    ++    V     P+S L + P+SP
Sbjct: 388 VTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASP 444



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + +   G LG +I GG + +  I IS I  G  AD +  L  GD I+SVN  DL +
Sbjct: 465 RKVVLHRGSTG-LGFNIVGGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522

Query: 146 ATHDEAVQVLKKTGKEVVLEVKY 168
           A+H++A   LK  G+ V +  +Y
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQY 545


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 16/119 (13%)

Query: 74  PPQLP--------------EALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFK 119
           PPQ+P              E    + R++ + K   G LG +I GG + +  I +S I  
Sbjct: 359 PPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG-LGFNIVGGEDGE-GIFVSFILA 416

Query: 120 GLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKN 178
           G  AD +  L  GD ILSVNG +L +ATH++A   LK+ G+ V +  +Y  +    F++
Sbjct: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFES 475



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 32/75 (42%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I I+KI +G AA +   L +GD +L+VN  +L    H+EA
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294

Query: 152 VQVLKKTGKEVVLEV 166
           V  LK T   V L+V
Sbjct: 295 VASLKNTSDMVYLKV 309


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 47/183 (25%), Positives = 76/183 (41%), Gaps = 19/183 (10%)

Query: 24   GGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLL 83
            G E     LL+ AE + T++         P     QE        +      + P+A   
Sbjct: 1093 GDESSNATLLTNAEKIATITTTH-----TPSQQGTQETRNTTKPKQESQFEFKAPQATQE 1147

Query: 84   QRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDL 143
            Q       +  A G G S++GGRE  M + + ++ +   A++   + +GD IL +NGE  
Sbjct: 1148 QDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1207

Query: 144  SSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPG 203
             +  H  A++++K  G+ V L +K      P +    GG          S  +  PS PG
Sbjct: 1208 KNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY----GG----------SNYENIPSFPG 1253

Query: 204  PTP 206
             TP
Sbjct: 1254 MTP 1256



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 24/68 (35%), Positives = 38/68 (55%)

Query: 99   GISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKT 158
            G +  G     MP  I +I +G  AD+   L VGD IL+VNG  +++ +H + V ++K+ 
Sbjct: 1023 GTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1082

Query: 159  GKEVVLEV 166
            G  V L +
Sbjct: 1083 GNTVTLRI 1090



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 7/113 (6%)

Query: 49  PGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGREN 108
           P P  G  + +   ++N         P   E  +   R+ T       G G  I GG E 
Sbjct: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKET-------GFGFRILGGNEP 861

Query: 109 KMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKE 161
             PI I  I    AAD    L  GD ++ V+G  +   +H   VQ++++  K+
Sbjct: 862 GEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQ 914



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 17/91 (18%)

Query: 132 GDAILSVNGEDLSSATHDEAVQVLKK--TGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDS 189
           GD I+ VN +++ + TH++ V +L +   G EV L V+             GG  V   S
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ------------RGGLPVPKKS 730

Query: 190 PPASPLQRQPSSPGPTPRNFSEAKHMSLKMA 220
           P + PL+R+ S         S + H SL  A
Sbjct: 731 PKSQPLERKDSQ---NSSQHSVSSHRSLHTA 758



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 29/120 (24%), Positives = 45/120 (37%), Gaps = 7/120 (5%)

Query: 49  PGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGREN 108
           P   P  P       L G       P +L    +  + R + R     G G ++ GG E 
Sbjct: 438 PNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR-----GFGFTVVGGDEP 492

Query: 109 KMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKK--TGKEVVLEV 166
              + I  +     A     +  GD I+SVN   +   TH + V++ +    G  V LE+
Sbjct: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 11/204 (5%)

Query: 24   GGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLL 83
            G E     LL+ AE + T++         P     QE        +      + P+A   
Sbjct: 1064 GDESSNATLLTNAEKIATITTTH-----TPSQQGTQETRNTTKPKQESQFEFKAPQATQE 1118

Query: 84   QRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDL 143
            Q       +  A G G S++GGRE  M + + ++ +   A++   + +GD IL +NGE  
Sbjct: 1119 QDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178

Query: 144  SSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTG--GTSVGWDSPP---ASPLQRQ 198
             +  H  A++++K  G+ V L +K      P +  S+   G + G    P   A P +RQ
Sbjct: 1179 KNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQ 1238

Query: 199  -PSSPGPTPRNFSEAKHMSLKMAY 221
             PS     P +  ++     K A+
Sbjct: 1239 HPSLESSYPPDLHKSSPHGEKRAH 1262



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 22/57 (38%), Positives = 35/57 (61%)

Query: 110  MPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
            MP  I +I +G  AD+   L VGD IL+VNG  +++ +H + V ++K+ G  V L +
Sbjct: 1005 MPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 22/65 (33%), Positives = 32/65 (49%)

Query: 97  GLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           G G  I GG E   PI I  I    AAD    L  GD ++ V+G  +   +H   VQ+++
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 881

Query: 157 KTGKE 161
           +  K+
Sbjct: 882 QAAKQ 886



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 17/91 (18%)

Query: 132 GDAILSVNGEDLSSATHDEAVQVLKK--TGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDS 189
           GD I+ VN +++ + TH++ V +L +   G EV L V+             GG  V   S
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ------------RGGLPVPKKS 730

Query: 190 PPASPLQRQPSSPGPTPRNFSEAKHMSLKMA 220
           P + PL+R+ S         S + H SL  A
Sbjct: 731 PKSQPLERKDSQ---NSSQHSVSSHRSLHTA 758



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 29/120 (24%), Positives = 45/120 (37%), Gaps = 7/120 (5%)

Query: 49  PGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGREN 108
           P   P  P       L G       P +L    +  + R + R     G G ++ GG E 
Sbjct: 438 PNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR-----GFGFTVVGGDEP 492

Query: 109 KMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKK--TGKEVVLEV 166
              + I  +     A     +  GD I+SVN   +   TH + V++ +    G  V LE+
Sbjct: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/118 (28%), Positives = 59/118 (50%), Gaps = 8/118 (6%)

Query: 65  NGAAEPGAG-----PPQLPEALLLQRRRVTVRKADAGGLGISIKGG---RENKMPILISK 116
           NG+  PG G     P  L   +    + V ++K     LG+++ GG   RE  +PI +  
Sbjct: 480 NGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVIS 539

Query: 117 IFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSP 174
           +  G    +   +  GD +L+V+G +L+  +  EAV +LK+T   +VL+   +K+  P
Sbjct: 540 VEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEP 597



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 4/94 (4%)

Query: 76  QLPEALLLQRRRVTVRKADAGGLGISIKGGREN---KMPILISKIFKGLAADQTEALFVG 132
           +LP  L    + + +R+  AG LG  I GG E      P  I  I +G  A     +  G
Sbjct: 628 ELPRCLY-NCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686

Query: 133 DAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
           D +L+VNG   S   H    ++LK+    + L +
Sbjct: 687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 22/61 (36%), Positives = 35/61 (57%), Gaps = 1/61 (1%)

Query: 98  LGISIKGGRENKMP-ILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           L I + GG E  +  I+I  I++     +   L  GD IL VNG D+S+  H+ AV++L+
Sbjct: 286 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345

Query: 157 K 157
           +
Sbjct: 346 Q 346


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/118 (28%), Positives = 59/118 (50%), Gaps = 8/118 (6%)

Query: 65  NGAAEPGAG-----PPQLPEALLLQRRRVTVRKADAGGLGISIKGG---RENKMPILISK 116
           NG+  PG G     P  L   +    + V ++K     LG+++ GG   RE  +PI +  
Sbjct: 384 NGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVIS 443

Query: 117 IFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSP 174
           +  G    +   +  GD +L+V+G +L+  +  EAV +LK+T   +VL+   +K+  P
Sbjct: 444 VEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEP 501



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 4/94 (4%)

Query: 76  QLPEALLLQRRRVTVRKADAGGLGISIKGGREN---KMPILISKIFKGLAADQTEALFVG 132
           +LP  L    + + +R+  AG LG  I GG E      P  I  I +G  A     +  G
Sbjct: 532 ELPRCLY-NCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590

Query: 133 DAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
           D +L+VNG   S   H    ++LK+    + L +
Sbjct: 591 DILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 22/61 (36%), Positives = 35/61 (57%), Gaps = 1/61 (1%)

Query: 98  LGISIKGGRENKMP-ILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           L I + GG E  +  I+I  I++     +   L  GD IL VNG D+S+  H+ AV++L+
Sbjct: 190 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249

Query: 157 K 157
           +
Sbjct: 250 Q 250


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 34/93 (36%), Positives = 53/93 (56%), Gaps = 2/93 (2%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R++ + K   G LG +I GG + +  I +S I  G  AD +  L  GD ILSVNG +L +
Sbjct: 48  RKIILHKGSTG-LGFNIVGGEDGE-GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKN 178
           ATH++A   LK+ G+ V +  +Y  +    F++
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFES 138


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 35/116 (30%), Positives = 58/116 (50%), Gaps = 16/116 (13%)

Query: 54   GAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKM--- 110
            G  R  +P+Q N   +             ++ R V + +  +  LGISI GGR + +   
Sbjct: 1656 GTKRVSDPSQKNSGTD-------------MEPRTVEINRELSDALGISIAGGRGSPLGDI 1702

Query: 111  PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEV 166
            P+ I+ I     A +T+ L VGD I+S+NG+ L   +H + V +LK     ++L+V
Sbjct: 1703 PVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 5/151 (3%)

Query: 88   VTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSAT 147
            V ++K    GLG+SI G R N   + IS I KG AAD    L  GD ILSVNGED+ +A+
Sbjct: 1534 VDLQKKAGRGLGLSIVGKR-NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592

Query: 148  HDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPR 207
             +    +LK     V LE+  ++  S     +T   S G      S      +      +
Sbjct: 1593 QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQ 1652

Query: 208  NFSEAKHMSLKMAYVSKRCTPNDPEPRYLEI 238
            N    K +S      S++ +  D EPR +EI
Sbjct: 1653 NLVGTKRVS----DPSQKNSGTDMEPRTVEI 1679



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 29/71 (40%), Positives = 49/71 (69%), Gaps = 1/71 (1%)

Query: 97   GLGISIKGGRENKM-PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVL 155
            GLG+SI GG++  +  I+I ++++  AA +   L+ GD IL VNG DL +++H+EA+  L
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505

Query: 156  KKTGKEVVLEV 166
            ++T ++V L V
Sbjct: 1506 RQTPQKVRLVV 1516



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 36/108 (33%), Positives = 56/108 (51%), Gaps = 5/108 (4%)

Query: 73   GPPQLPEALLLQRRRVTVRKADAGGLGI--SIKGGRENKMPILISKIFKGLAADQTEALF 130
            GPP++ E  + +   V++  +  GG  +   +K G E K  I I ++ +   A +T AL 
Sbjct: 1064 GPPRIVE--IFREPNVSLGISIVGGQTVIKRLKNGEELK-GIFIKQVLEDSPAGKTNALK 1120

Query: 131  VGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKN 178
             GD IL V+G DL +A+H EAV+ +K  G  VV  V+ +        N
Sbjct: 1121 TGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 11/137 (8%)

Query: 59  QEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIF 118
           +EP     +         LPE +            D  GLG  I GG+ +   +++  I 
Sbjct: 219 REPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIV 276

Query: 119 KGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKN 178
            G  AD+   L  GD IL + G ++   T ++  QVL+  G  V + V          ++
Sbjct: 277 PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVA---------RD 327

Query: 179 STGGTSVGWDSPPASPL 195
             G  SV   +P A P+
Sbjct: 328 PAGDISVTPPAPAALPV 344



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)

Query: 94  DAGGLGISIKGGRENKMPILISKIFKGLAAD----QTEALFVGDAILSVNGEDLSSATHD 149
           D  GLG SI   ++   P     + + L AD    ++  L  GD ++SVN   L + +  
Sbjct: 692 DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLA 751

Query: 150 EAVQVLK 156
           EAV++LK
Sbjct: 752 EAVEILK 758


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 51/183 (27%), Positives = 78/183 (42%), Gaps = 27/183 (14%)

Query: 47   GDPGPEPG-----------APREQEPAQLNG---AAEPGAGPPQLPEALLLQRRRVTVRK 92
            G+P PE G           +PR       N    A    A PP+   +  LQ   V + +
Sbjct: 866  GEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHR 925

Query: 93   ADAGGLGISI-------KGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
             +  G G  I       + G    +P  I +I  G  AD+   L VGD IL+VNG+ + +
Sbjct: 926  KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985

Query: 146  ATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPA--SPLQRQPSSPG 203
              H + V+++K  G  V L +   ++++    + T   S    SP A  SPL +Q     
Sbjct: 986  MPHADIVKLIKDAGLSVTLRIIPQEELN----SPTSAPSSEKQSPMAQQSPLAQQSPLAQ 1041

Query: 204  PTP 206
            P+P
Sbjct: 1042 PSP 1044



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 5/99 (5%)

Query: 95   AGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQV 154
            A G G SI+GGRE KM + + ++ +   A +   + VGD I+ +NGE     TH  A+++
Sbjct: 1154 AKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL 1213

Query: 155  LKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPAS 193
            +K  G+ V L +K      P +          W SP A+
Sbjct: 1214 IKSGGRRVRLLLKRGTGQVPEYDE-----PAPWSSPAAA 1247



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 31/126 (24%), Positives = 49/126 (38%), Gaps = 12/126 (9%)

Query: 97  GLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLK 156
           G G  I GG E   PILI  +    +AD+   L  GD ++ V+G  ++  TH   + ++ 
Sbjct: 787 GFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMH 846

Query: 157 KTGKEVVLEVKYMKDV------SPYFKNSTGGTSVGWDSPPA------SPLQRQPSSPGP 204
              +   + +   + V       P    S G  S    SP +      +     PSS   
Sbjct: 847 HAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNAS 906

Query: 205 TPRNFS 210
            P  F+
Sbjct: 907 PPEGFA 912



 Score = 29.6 bits (65), Expect = 6.7
 Identities = 52/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)

Query: 89  TVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATH 148
           T++K++ G  G +I GG E    + +  +     A Q   +  GD I+ +N   +   TH
Sbjct: 428 TLKKSNMG-FGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486

Query: 149 DEAVQVLKKT--GKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTP 206
            + V++ +    G+ V L V       P+       + V    PP + ++R      P P
Sbjct: 487 ADVVKLFQSVPIGQSVNL-VLCRGYPLPFDPEDPANSMV----PPLAIMER------PPP 535

Query: 207 RNFSEAKHMSLKMAYVSK--RCTPN--DPEPRYLEICSADGQ--DTLFLRAKDEASARSW 260
              +   +    + Y+S+  +  P+  D  P  L     DGQ   T      D+  + + 
Sbjct: 536 VMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMAS 595

Query: 261 ATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQI 297
           + A QA++ TLT     +      A S  G Q +KQI
Sbjct: 596 SGATQAELMTLTIVKGAQGFGFTIADSPTG-QRVKQI 631


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 52/155 (33%), Positives = 69/155 (44%), Gaps = 24/155 (15%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI  G AA +   L VGD +L VN   L   TH+EA
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 152 VQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWD-SPPA---------SPLQRQPSS 201
           V +LK T + V L+V   K  + Y  +  G   +    SPP            L+ + S 
Sbjct: 367 VAILKNTSEVVYLKVG--KPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSL 424

Query: 202 PGPTPRNFSE-AKHMSLKMAYVSKRCTPNDPEPRY 235
           P  +P  +S   KHM +   Y         PEP Y
Sbjct: 425 PPISPGRYSPIPKHMLVDDDYT------RPPEPVY 453



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 34/86 (39%), Positives = 48/86 (55%), Gaps = 2/86 (2%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + K   G LG +I GG + +  I +S I  G  AD +  L  GD ILSVNG DL  
Sbjct: 525 RKVVLHKGSTG-LGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 582

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYMKD 171
           A+H++A   LK  G+ V +  +Y  +
Sbjct: 583 ASHEQAAAALKGAGQTVTIIAQYQPE 608



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 34/90 (37%), Positives = 50/90 (55%), Gaps = 6/90 (6%)

Query: 88  VTVRKADAGGLGISIKGGREN-----KMPILISKIFKGLAADQTEALFVGDAILSVNGED 142
           +T+ + ++G LG SI GG +N        I I+KI  G AA +   L V D IL VN  D
Sbjct: 204 ITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262

Query: 143 LSSATHDEAVQVLKKTGKEVVLEVKYMKDV 172
           +S  +H +AV+ LK+ G  V L V+  + +
Sbjct: 263 VSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 52/155 (33%), Positives = 69/155 (44%), Gaps = 24/155 (15%)

Query: 97  GLGISIKGGRENKM-----PILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151
           GLG SI GG  N+       I ++KI  G AA +   L VGD +L VN   L   TH+EA
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 152 VQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWD-SPPA---------SPLQRQPSS 201
           V +LK T + V L+V   K  + Y  +  G   +    SPP            L+ + S 
Sbjct: 262 VAILKNTSEVVYLKVG--KPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSL 319

Query: 202 PGPTPRNFSE-AKHMSLKMAYVSKRCTPNDPEPRY 235
           P  +P  +S   KHM +   Y         PEP Y
Sbjct: 320 PPISPGRYSPIPKHMLVDDDYT------RPPEPVY 348



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 34/86 (39%), Positives = 48/86 (55%), Gaps = 2/86 (2%)

Query: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
           R+V + K   G LG +I GG + +  I +S I  G  AD +  L  GD ILSVNG DL  
Sbjct: 420 RKVVLHKGSTG-LGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 477

Query: 146 ATHDEAVQVLKKTGKEVVLEVKYMKD 171
           A+H++A   LK  G+ V +  +Y  +
Sbjct: 478 ASHEQAAAALKGAGQTVTIIAQYQPE 503



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 34/90 (37%), Positives = 50/90 (55%), Gaps = 6/90 (6%)

Query: 88  VTVRKADAGGLGISIKGGREN-----KMPILISKIFKGLAADQTEALFVGDAILSVNGED 142
           +T+ + ++G LG SI GG +N        I I+KI  G AA +   L V D IL VN  D
Sbjct: 99  ITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157

Query: 143 LSSATHDEAVQVLKKTGKEVVLEVKYMKDV 172
           +S  +H +AV+ LK+ G  V L V+  + +
Sbjct: 158 VSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,080,797
Number of Sequences: 37866
Number of extensions: 1188011
Number of successful extensions: 5345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 4830
Number of HSP's gapped (non-prelim): 572
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.