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Search of human proteins with 4505111
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
(496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens] 966 0.0
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens] 460 e-129
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens] 449 e-126
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens] 278 1e-74
gi|11321565 matrilin 3 precursor [Homo sapiens] 276 3e-74
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 246 3e-65
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 243 4e-64
gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens] 195 7e-50
gi|156616290 collagen type VI alpha 6 [Homo sapiens] 186 6e-47
gi|21359974 vitrin [Homo sapiens] 184 2e-46
gi|205277471 cochlin precursor [Homo sapiens] 160 3e-39
gi|4758022 cochlin precursor [Homo sapiens] 160 3e-39
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens] 160 3e-39
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 157 3e-38
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 157 3e-38
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 157 3e-38
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [... 150 2e-36
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens] 150 2e-36
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 149 6e-36
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ... 145 8e-35
gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo ... 142 5e-34
gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo ... 139 5e-33
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa... 131 2e-30
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens] 130 2e-30
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 125 7e-29
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 111 1e-24
gi|89191868 von Willebrand factor preproprotein [Homo sapiens] 110 4e-24
gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens] 94 3e-19
gi|40068485 von Willebrand factor A domain containing 1 isoform ... 94 3e-19
gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens] 94 4e-19
>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
Length = 496
Score = 966 bits (2497), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKV 60
MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKV
Sbjct: 1 MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKV 60
Query: 61 KVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT 120
KVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT
Sbjct: 61 KVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT 120
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV
Sbjct: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCIS 240
GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCIS
Sbjct: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCIS 240
Query: 241 SPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQ 300
SPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQ
Sbjct: 241 SPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQ 300
Query: 301 IVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKY 360
IVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKY
Sbjct: 301 IVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKY 360
Query: 361 LIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELR 420
LIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELR
Sbjct: 361 LIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELR 420
Query: 421 EIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRK 480
EIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRK
Sbjct: 421 EIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRK 480
Query: 481 LEAVSKRLAILENTVV 496
LEAVSKRLAILENTVV
Sbjct: 481 LEAVSKRLAILENTVV 496
>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
Length = 499
Score = 460 bits (1184), Expect = e-129
Identities = 253/492 (51%), Positives = 330/492 (67%), Gaps = 20/492 (4%)
Query: 14 LLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDV 73
LLLLLQ + Q G C T P DLVFV+DSSRSVRP EFE ++ FL ++ L+V
Sbjct: 10 LLLLLQPWETQ---LQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNV 66
Query: 74 GPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFG 133
GPNATRVG++ Y+S V+ F LRA + + +A+R + PL+ GTMTGLAIQ+A+ AF
Sbjct: 67 GPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFS 126
Query: 134 DAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIAS 193
AEG R + +V ++VTDGRPQD V +V+A+ARA G+E++A+GV D +LR +AS
Sbjct: 127 VAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMAS 186
Query: 194 EPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253
P DEHV VES+ +I++ +FQ C V DLC DH CE C+S SY C C EG
Sbjct: 187 PPLDEHVFLVESFDLIQEFGLQFQSRLC-VRDLCNGVDHGCEFQCVSEGLSYRCLCPEGR 245
Query: 254 TLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQ 313
L +DGK+CN C G DLV L+DGSKSVRP+NFELVK+F++QIVD LDVS + +
Sbjct: 246 QLQADGKSCNRCREG----HVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTR 301
Query: 314 VGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR 373
VGLVQ+SS VR EFPLGR+ T ++K AV + YME+GTMTG AL++++++SF+ + GAR
Sbjct: 302 VGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGAR 361
Query: 374 PGA---QKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEH 430
P A +VG+VFTDGRSQD I+ A +AK+ G M+AVGVG AVE ELREIASEP H
Sbjct: 362 PRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELH 421
Query: 431 YFYTADFKTINQIGKKLQKKICVEE---------DPCACESLVKFQAKVEGLLQALTRKL 481
Y DF T+ + + L+ IC EE PC CESLV+FQ + G L++LT L
Sbjct: 422 VSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNL 481
Query: 482 EAVSKRLAILEN 493
++ RL LEN
Sbjct: 482 AQLTARLEDLEN 493
>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
Length = 540
Score = 449 bits (1155), Expect = e-126
Identities = 252/533 (47%), Positives = 334/533 (62%), Gaps = 61/533 (11%)
Query: 14 LLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDV 73
LLLLLQ + Q G C T P DLVFV+DSSRSVRP EFE ++ FL ++ L+V
Sbjct: 10 LLLLLQPWETQ---LQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNV 66
Query: 74 GPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFG 133
GPNATRVG++ Y+S V+ F LRA + + +A+R + PL+ GTMTGLAIQ+A+ AF
Sbjct: 67 GPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFS 126
Query: 134 DAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIAS 193
AEG R + +V ++VTDGRPQD V +V+A+ARA G+E++A+GV D +LR +AS
Sbjct: 127 VAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMAS 186
Query: 194 EPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPG---------- 243
P DEHV VES+ +I++ +FQ C + D C+ G+H C+ C+S+PG
Sbjct: 187 PPLDEHVFLVESFDLIQEFGLQFQSRLCAI-DYCSFGNHSCQHECVSTPGGPRCHCREGH 245
Query: 244 -------------------------------SYTCACHEGFTLNSDGKTCNVCSGGGGSS 272
SY C C EG L +DGK+CN C G
Sbjct: 246 DLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGH--- 302
Query: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRF 332
DLV L+DGSKSVRP+NFELVK+F++QIVD LDVS + +VGLVQ+SS VR EFPLGR+
Sbjct: 303 -VDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRY 361
Query: 333 HTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGA---QKVGIVFTDGRSQ 389
T ++K AV + YME+GTMTG AL++++++SF+ + GARP A +VG+VFTDGRSQ
Sbjct: 362 GTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQ 421
Query: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQK 449
D I+ A +AK+ G M+AVGVG AVE ELREIASEP H Y DF T+ + + L+
Sbjct: 422 DDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRG 481
Query: 450 KICVEE---------DPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493
IC EE PC CESLV+FQ + G L++LT L ++ RL LEN
Sbjct: 482 SICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLEN 534
>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
Length = 581
Score = 278 bits (710), Expect = 1e-74
Identities = 151/285 (52%), Positives = 191/285 (67%), Gaps = 16/285 (5%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280
C V DLC DH CE C+S SY C C EG L +DGK+CN C G DLV L+
Sbjct: 295 CQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGH----VDLVLLV 350
Query: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340
DGSKSVRP+NFELVK+F++QIVD LDVS + +VGLVQ+SS VR EFPLGR+ T ++K
Sbjct: 351 DGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQ 410
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGA---QKVGIVFTDGRSQDYINDAAK 397
AV + YME+GTMTG AL++++++SF+ + GARP A +VG+VFTDGRSQD I+ A
Sbjct: 411 AVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAA 470
Query: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEE-- 455
+AK+ G M+AVGVG AVE ELREIASEP H Y DF T+ + + L+ IC EE
Sbjct: 471 RAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGI 530
Query: 456 -------DPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493
PC CESLV+FQ + G L++LT L ++ RL LEN
Sbjct: 531 SAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLEN 575
Score = 243 bits (621), Expect = 2e-64
Identities = 142/322 (44%), Positives = 191/322 (59%), Gaps = 8/322 (2%)
Query: 14 LLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDV 73
LLLLLQ + Q G C T P DLVFV+DSSRSVRP EFE ++ FL ++ L+V
Sbjct: 10 LLLLLQPWETQ---LQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNV 66
Query: 74 GPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFG 133
GPNATRVG++ Y+S V+ F LRA + + +A+R + PL+ GTMTGLAIQ+A+ AF
Sbjct: 67 GPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFS 126
Query: 134 DAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIAS 193
AEG R + +V ++VTDGRPQD V +V+A+ARA G+E++A+GV D +LR +AS
Sbjct: 127 VAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMAS 186
Query: 194 EPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253
P DEHV VES+ +I++ +FQ C + DLCA G H CE C++SPGSY C C GF
Sbjct: 187 PPLDEHVFLVESFDLIQEFGLQFQSRLCAI-DLCAEGTHGCEHHCVNSPGSYFCHCQVGF 245
Query: 254 TLNSDGKTC---NVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFIS-QIVDTLDVSD 309
L D ++C + CS G S + V G + E +L S Q+ D + D
Sbjct: 246 VLQQDQRSCRAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVD 305
Query: 310 KLAQVGLVQYSSSVRQEFPLGR 331
+ V S R P GR
Sbjct: 306 HGCEFQCVSEGLSYRCLCPEGR 327
Score = 161 bits (408), Expect = 1e-39
Identities = 91/246 (36%), Positives = 139/246 (56%), Gaps = 5/246 (2%)
Query: 16 LLLQALCSPGLAPQSRG---HLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD 72
L + LC G Q+ G + CR DLV +VD S+SVRP FE VK F++Q+++ LD
Sbjct: 317 LSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLD 376
Query: 73 VGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAF 132
V P TRVG+V ++S V+ EF L + + A + QAV ++ + GTMTGLA++ + +F
Sbjct: 377 VSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSF 436
Query: 133 GDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIA 192
+A+G R R+ ++ +V +V TDGR QD + +ARA+ G+ ++A+GVG +A LR+IA
Sbjct: 437 SEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIA 496
Query: 193 SEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGD--HDCEQVCISSPGSYTCACH 250
SEP + HV Y + + L + + C + A + CE + T
Sbjct: 497 SEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGAL 556
Query: 251 EGFTLN 256
E TLN
Sbjct: 557 ESLTLN 562
Score = 144 bits (362), Expect = 2e-34
Identities = 74/188 (39%), Positives = 120/188 (63%), Gaps = 4/188 (2%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
DLVF+ID S+SVRP FE +++F+ ++ L+V +VG++QYSS V+ FPL F
Sbjct: 34 DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQ---KVGIVFTDGRSQDY 391
++D++ A+R++ + +GTMTG A++Y ++ +F+V+ GARP + +V ++ TDGR QD
Sbjct: 94 REDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDR 153
Query: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
+ + A +A+ G +++AVGV A LR +AS P+ EH F F I + G + Q ++
Sbjct: 154 VAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRL 213
Query: 452 CVEEDPCA 459
C D CA
Sbjct: 214 CA-IDLCA 220
>gi|11321565 matrilin 3 precursor [Homo sapiens]
Length = 486
Score = 276 bits (706), Expect = 3e-74
Identities = 137/231 (59%), Positives = 177/231 (76%), Gaps = 2/231 (0%)
Query: 34 LCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEF 93
+C++RP DLVF++DSSRSVRP+EF KVK F+S++I++LD+GP TRV +VNYASTVK EF
Sbjct: 76 VCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEF 135
Query: 94 SLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVT 153
L+A+ K +L QAV RI PLSTGTM+GLAIQ A+ +AF G R S +I KV I+VT
Sbjct: 136 QLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVT 195
Query: 154 DGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLS 213
DGRPQD V +V+ARA+ASG+EL+A+GV D A+L+ +ASEP +EHV YVE+Y VIEKLS
Sbjct: 196 DGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLS 255
Query: 214 RKFQEAFCVVSDLCATGDHDCEQVCIS-SPGSYTCACHEGFTLNSDGKTCN 263
+FQE FC + D C G H C+ VCIS G + C C +G+TLN+D KTC+
Sbjct: 256 SRFQETFCAL-DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCS 305
Score = 150 bits (378), Expect = 3e-36
Identities = 79/191 (41%), Positives = 119/191 (62%), Gaps = 4/191 (2%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S DLVF+ID S+SVRP F VK F+S+I+DTLD+ +V +V Y+S+V+ EF L
Sbjct: 79 SRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQ 138
Query: 331 RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQ---KVGIVFTDGR 387
+ K+ +K AV ++ + GTM+G A++ +D +FTV +GAR + KV I+ TDGR
Sbjct: 139 AYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGR 198
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
QD +N+ A +A+ G +++AVGV A L+ +ASEP+ EH FY + I ++ +
Sbjct: 199 PQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRF 258
Query: 448 QKKICVEEDPC 458
Q+ C DPC
Sbjct: 259 QETFCA-LDPC 268
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 8/89 (8%)
Query: 199 HVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISS-PGSYTCACHEGFTLNS 257
H + E Y++ E C D CA G H C+ +C++ GS+ C C+EG+TLN+
Sbjct: 330 HCECYEGYTLNE------DRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNA 383
Query: 258 DGKTCNVCSGGG-GSSATDLVFLIDGSKS 285
D KTC+V GS + + DG+ S
Sbjct: 384 DKKTCSVRDKCALGSHGCQHICVSDGAAS 412
Score = 54.7 bits (130), Expect = 2e-07
Identities = 22/44 (50%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 221 CVVSDLCATGDHDCEQVCISS-PGSYTCACHEGFTLNSDGKTCN 263
C V D CA G H C+ +C+S SY C C+ G+TLN D KTC+
Sbjct: 388 CSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCS 431
Score = 37.4 bits (85), Expect = 0.032
Identities = 17/44 (38%), Positives = 26/44 (59%)
Query: 449 KKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILE 492
+++ ED C CE+ + FQ KV LQ L KL+ + ++L I E
Sbjct: 437 RRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINE 480
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 246 bits (629), Expect = 3e-65
Identities = 137/332 (41%), Positives = 191/332 (57%), Gaps = 63/332 (18%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280
C D+C + H CE +C+++ SY C C EGF L DG+ C C+ G DLVF+I
Sbjct: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG----PIDLVFVI 660
Query: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340
DGSKS+ ENFE+VK+F++ I+D+L +S K A+VGL+QYS+ V EF L F++ KD+K
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKV---GIVFTDGRSQDYINDAAK 397
AV +M YM KG+MTG ALK++ + SFT GARP + +V IVFTDGR+QD +++ A
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
Query: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC----- 452
KAK G M+AVGVG A+E+EL+EIASEP +H FY DF T+++I +KL+K IC
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
Query: 453 --------------------------VEED-------------------------PCACE 461
EED C CE
Sbjct: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
Query: 462 SLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493
+L+ FQ ++ LT++LE +++R+ LEN
Sbjct: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALEN 932
Score = 243 bits (619), Expect = 4e-64
Identities = 126/273 (46%), Positives = 179/273 (65%), Gaps = 21/273 (7%)
Query: 12 CSLLLLLQALCSPGLAPQ-------SRGHLCRTRP-------------TDLVFVVDSSRS 51
C LL+L Q + P A + SRG RT P DLVF++DSSRS
Sbjct: 8 CFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRS 67
Query: 52 VRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRI 111
V ++ KVK F+ +++ LD+GP+ TRVG++ Y STVK EFSL+ K+ + +AV+R+
Sbjct: 68 VNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRM 127
Query: 112 QPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARAS 171
+ LSTGTMTGLAIQ+A+ AF +AEG R ++ +V+++VTDGRPQDSV +V+A+AR +
Sbjct: 128 RHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDT 187
Query: 172 GVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGD 231
G+ +FAIGVG VD TL+ I SEP ++HV V ++S IE L+ FQ+ C + +C+T +
Sbjct: 188 GILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLC-TAHMCSTLE 246
Query: 232 HDCEQVCISSPGSYTCACHEGFTLNSDGKTCNV 264
H+C CI+ PGSY C C +G+ LNSD TC +
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRI 279
Score = 153 bits (386), Expect = 4e-37
Identities = 76/203 (37%), Positives = 125/203 (61%), Gaps = 3/203 (1%)
Query: 22 CSPGLAPQSRGHLCRT---RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNAT 78
CS G G C+ P DLVFV+D S+S+ FE VK F++ +I+SL + P A
Sbjct: 633 CSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAA 692
Query: 79 RVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGG 138
RVG++ Y++ V EF+LR S + +AV ++ + G+MTGLA++ ++F EG
Sbjct: 693 RVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGA 752
Query: 139 RSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDE 198
R S + + IV TDGR QD V + +++A+A+G+ ++A+GVG + L++IASEP ++
Sbjct: 753 RPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNK 812
Query: 199 HVDYVESYSVIEKLSRKFQEAFC 221
H+ Y E +S ++++S K ++ C
Sbjct: 813 HLFYAEDFSTMDEISEKLKKGIC 835
Score = 147 bits (371), Expect = 2e-35
Identities = 74/181 (40%), Positives = 113/181 (62%), Gaps = 3/181 (1%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
DLVF+ID S+SV ++ VK+FI I+ LD+ + +VGL+QY S+V+ EF L F
Sbjct: 57 DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP---GAQKVGIVFTDGRSQDY 391
K +++ AV+ M ++ GTMTG A++Y ++ +F+ + GARP +V ++ TDGR QD
Sbjct: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
Query: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
+ + A KA+D G +FA+GVG + L+ I SEP +H F A+F I + QKK+
Sbjct: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
Query: 452 C 452
C
Sbjct: 237 C 237
Score = 62.8 bits (151), Expect = 7e-10
Identities = 24/42 (57%), Positives = 29/42 (69%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
CV D CA+ +H CE C+++ GSY C CHEGF LN D KTC
Sbjct: 318 CVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Score = 58.9 bits (141), Expect = 1e-08
Identities = 23/42 (54%), Positives = 26/42 (61%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
C D CA GDH CE C+SS S+ C C EG+ L DGKTC
Sbjct: 523 CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
Score = 54.3 bits (129), Expect = 3e-07
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC---NVCS 266
C D CA+ +H C+ C+++ SY+C C +GFTLN D KTC N C+
Sbjct: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA 407
Score = 53.9 bits (128), Expect = 3e-07
Identities = 21/43 (48%), Positives = 28/43 (65%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCN 263
C D CA DH CEQ+C+++ S+ C C EGF +N D KTC+
Sbjct: 441 CSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Score = 50.1 bits (118), Expect = 5e-06
Identities = 20/42 (47%), Positives = 23/42 (54%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
C D C DH CE C++ S+ C C EG L SDGKTC
Sbjct: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
Score = 47.8 bits (112), Expect = 2e-05
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 196 QDEHVDYVESYSV--IEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253
Q E V+ +SYS ++ + + C + CA CE C++ SY C CH G+
Sbjct: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432
Query: 254 TLNSDGKTCN 263
TL+ +GKTC+
Sbjct: 433 TLDPNGKTCS 442
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 243 bits (619), Expect = 4e-64
Identities = 126/273 (46%), Positives = 179/273 (65%), Gaps = 21/273 (7%)
Query: 12 CSLLLLLQALCSPGLAPQ-------SRGHLCRTRP-------------TDLVFVVDSSRS 51
C LL+L Q + P A + SRG RT P DLVF++DSSRS
Sbjct: 8 CFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRS 67
Query: 52 VRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRI 111
V ++ KVK F+ +++ LD+GP+ TRVG++ Y STVK EFSL+ K+ + +AV+R+
Sbjct: 68 VNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRM 127
Query: 112 QPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARAS 171
+ LSTGTMTGLAIQ+A+ AF +AEG R ++ +V+++VTDGRPQDSV +V+A+AR +
Sbjct: 128 RHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDT 187
Query: 172 GVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGD 231
G+ +FAIGVG VD TL+ I SEP ++HV V ++S IE L+ FQ+ C + +C+T +
Sbjct: 188 GILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLC-TAHMCSTLE 246
Query: 232 HDCEQVCISSPGSYTCACHEGFTLNSDGKTCNV 264
H+C CI+ PGSY C C +G+ LNSD TC +
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRI 279
Score = 242 bits (618), Expect = 5e-64
Identities = 120/235 (51%), Positives = 164/235 (69%), Gaps = 7/235 (2%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280
C D+C + H CE +C+++ SY C C EGF L DG+ C C+ G DLVF+I
Sbjct: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG----PIDLVFVI 660
Query: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340
DGSKS+ ENFE+VK+F++ I+D+L +S K A+VGL+QYS+ V EF L F++ KD+K
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKV---GIVFTDGRSQDYINDAAK 397
AV +M YM KG+MTG ALK++ + SFT GARP + +V IVFTDGR+QD +++ A
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
Query: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC 452
KAK G M+AVGVG A+E+EL+EIASEP +H FY DF T+++I +KL+K IC
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGIC 835
Score = 153 bits (386), Expect = 4e-37
Identities = 76/203 (37%), Positives = 125/203 (61%), Gaps = 3/203 (1%)
Query: 22 CSPGLAPQSRGHLCRT---RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNAT 78
CS G G C+ P DLVFV+D S+S+ FE VK F++ +I+SL + P A
Sbjct: 633 CSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAA 692
Query: 79 RVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGG 138
RVG++ Y++ V EF+LR S + +AV ++ + G+MTGLA++ ++F EG
Sbjct: 693 RVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGA 752
Query: 139 RSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDE 198
R S + + IV TDGR QD V + +++A+A+G+ ++A+GVG + L++IASEP ++
Sbjct: 753 RPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNK 812
Query: 199 HVDYVESYSVIEKLSRKFQEAFC 221
H+ Y E +S ++++S K ++ C
Sbjct: 813 HLFYAEDFSTMDEISEKLKKGIC 835
Score = 147 bits (371), Expect = 2e-35
Identities = 74/181 (40%), Positives = 113/181 (62%), Gaps = 3/181 (1%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
DLVF+ID S+SV ++ VK+FI I+ LD+ + +VGL+QY S+V+ EF L F
Sbjct: 57 DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP---GAQKVGIVFTDGRSQDY 391
K +++ AV+ M ++ GTMTG A++Y ++ +F+ + GARP +V ++ TDGR QD
Sbjct: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
Query: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
+ + A KA+D G +FA+GVG + L+ I SEP +H F A+F I + QKK+
Sbjct: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
Query: 452 C 452
C
Sbjct: 237 C 237
Score = 62.8 bits (151), Expect = 7e-10
Identities = 24/42 (57%), Positives = 29/42 (69%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
CV D CA+ +H CE C+++ GSY C CHEGF LN D KTC
Sbjct: 318 CVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Score = 58.9 bits (141), Expect = 1e-08
Identities = 23/42 (54%), Positives = 26/42 (61%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
C D CA GDH CE C+SS S+ C C EG+ L DGKTC
Sbjct: 523 CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
Score = 54.3 bits (129), Expect = 3e-07
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC---NVCS 266
C D CA+ +H C+ C+++ SY+C C +GFTLN D KTC N C+
Sbjct: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA 407
Score = 53.9 bits (128), Expect = 3e-07
Identities = 21/43 (48%), Positives = 28/43 (65%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCN 263
C D CA DH CEQ+C+++ S+ C C EGF +N D KTC+
Sbjct: 441 CSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Score = 50.1 bits (118), Expect = 5e-06
Identities = 20/42 (47%), Positives = 23/42 (54%)
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
C D C DH CE C++ S+ C C EG L SDGKTC
Sbjct: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
Score = 47.8 bits (112), Expect = 2e-05
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 196 QDEHVDYVESYSV--IEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253
Q E V+ +SYS ++ + + C + CA CE C++ SY C CH G+
Sbjct: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432
Query: 254 TLNSDGKTCN 263
TL+ +GKTC+
Sbjct: 433 TLDPNGKTCS 442
Score = 36.2 bits (82), Expect = 0.071
Identities = 18/50 (36%), Positives = 30/50 (60%), Gaps = 4/50 (8%)
Query: 444 GKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493
G L++K D C CE+L+ FQ ++ LT++LE +++R+ LEN
Sbjct: 906 GSPLEEK----HDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALEN 951
>gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]
Length = 2526
Score = 195 bits (496), Expect = 7e-50
Identities = 120/420 (28%), Positives = 218/420 (51%), Gaps = 51/420 (12%)
Query: 37 TRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLR 96
T+ D+ F++D S S++ +FE++K F+ +V E +GP+ RVG+V Y+ + EF +
Sbjct: 438 TKEADIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYIT 497
Query: 97 AHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGR 156
+ + L +A+ I+ L+ GT TG A+ + + G + R + +IV+TDG
Sbjct: 498 DYSNDIDLRKAIFNIKQLTGGTYTGKALDYILQII---KNGMKDRMSKVPCYLIVLTDGM 554
Query: 157 PQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKF 216
D V + + R RA + + A+G+G+ +K L++IA + +E V + +++ ++ + +
Sbjct: 555 STDRVVEPAKRLRAEQITVHAVGIGAANKIELQEIAGK--EERVSFGQNFDALKSIKNE- 611
Query: 217 QEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDL 276
VV ++CA + CE + D+
Sbjct: 612 -----VVREICA--EKGCEDM-----------------------------------KADI 629
Query: 277 VFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKK 336
+FL+D S S+ ENF +K F+ ++ + + Q+G+VQ+S ++EF L R+ T++
Sbjct: 630 MFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFTQQ 689
Query: 337 DIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAA 396
+I A+ MS + +GT+TG AL + + FT S GAR GA+K I+ TDG +QD + D A
Sbjct: 690 EISDAIDRMSLINEGTLTGKALNF-VGQYFTHSKGARLGAKKFLILITDGVAQDDVRDPA 748
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEED 456
+ + +F+VGV NA +L EI+ + + F+ +F + + +KL ++C D
Sbjct: 749 RILRGKDVTIFSVGVYNANRSQLEEISGD--SSLVFHVENFDHLKALERKLIFRVCALHD 806
Score = 156 bits (395), Expect = 4e-38
Identities = 109/426 (25%), Positives = 202/426 (47%), Gaps = 39/426 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
DLVF+VD S ++ FL + S+DV N R+G+++Y+++ K L++ +
Sbjct: 236 DLVFLVDESLGTGG-NLRHLQTFLENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTT 294
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
++ Q ++ + + TG AI F ++ G R R+ + ++ ++VT D
Sbjct: 295 QSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSR-RAQGVPQIAVLVTHRPSDDE 353
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAF 220
V D + R V +FA+ + + L +I S P ++ + ++SY+ +E S KF +
Sbjct: 354 VHDAALNLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTISTLKSYADLETYSTKFLKK- 412
Query: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280
+ +++ + EQ + G + D+ FLI
Sbjct: 413 -LQNEIWSQISTYAEQRNLDKTGCVD------------------------TKEADIHFLI 447
Query: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340
DGS S++ + FE +K+F+ ++ + + +VG+VQYS EF + + D++
Sbjct: 448 DGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRK 507
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVG---IVFTDGRSQDYINDAAK 397
A+ N+ + GT TG AL Y++ + +G + KV IV TDG S D + + AK
Sbjct: 508 AIFNIKQLTGGTYTGKALDYILQ---IIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAK 564
Query: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDP 457
+ + + AVG+G A + EL+EIA + E + +F + I ++ ++IC E+
Sbjct: 565 RLRAEQITVHAVGIGAANKIELQEIAGK--EERVSFGQNFDALKSIKNEVVREICAEK-- 620
Query: 458 CACESL 463
CE +
Sbjct: 621 -GCEDM 625
Score = 154 bits (388), Expect = 2e-37
Identities = 109/424 (25%), Positives = 203/424 (47%), Gaps = 55/424 (12%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFS 94
C D++F+VDSS S+ F K+K+F+ ++ + +G + T++G+V ++ K+EF
Sbjct: 622 CEDMKADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKTKEEFQ 681
Query: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTD 154
L + ++ + A+ R+ ++ GT+TG A+ F + + F ++G R + K +I++TD
Sbjct: 682 LNRYFTQQEISDAIDRMSLINEGTLTGKALNF-VGQYFTHSKGARLGA---KKFLILITD 737
Query: 155 GRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSR 214
G QD V+D + R V +F++GV + +++ L +I+ + V +VE++ ++ L R
Sbjct: 738 GVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGD--SSLVFHVENFDHLKALER 795
Query: 215 KFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSAT 274
K C + HDC+++ +
Sbjct: 796 KLIFRVCAL--------HDCKRITL----------------------------------L 813
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+VF++D S S++ + + + +V DV Q G ++YS F L +
Sbjct: 814 DVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSN 873
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDY- 391
+ I +R T T ALK+ + FT G+R +++ IV TDG S D+
Sbjct: 874 RSAIIENLRKRRDTGGNTYTAKALKH-ANALFTEEHGSRIKQNVKQMLIVITDGESHDHD 932
Query: 392 -INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKK 450
+ND A + ++ G +FAVGVG A + EL +A + Y +F + + +Q++
Sbjct: 933 QLNDTALELRNKGITIFAVGVGKANQKELEGMAGN--KNNTIYVDNFDKLKDVFTLVQER 990
Query: 451 ICVE 454
+C E
Sbjct: 991 MCTE 994
Score = 123 bits (309), Expect = 3e-28
Identities = 99/418 (23%), Positives = 187/418 (44%), Gaps = 54/418 (12%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VFV+D S S++ + + +++ DVG + + G + Y+ F L + +
Sbjct: 814 DVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSN 873
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
++A+++ +R+ + T T A++ A F + G R + ++ +++IV+TDG D
Sbjct: 874 RSAIIENLRKRRDTGGNTYTAKALKHA-NALFTEEHGSRIKQ-NVKQMLIVITDGESHDH 931
Query: 161 VQ--DVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
Q D + R G+ +FA+GVG ++ L +A + YV+++ K ++
Sbjct: 932 DQLNDTALELRNKGITIFAVGVGKANQKELEGMAGNKNN--TIYVDNFD-------KLKD 982
Query: 219 AFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVF 278
F +V E++C +P CH D++F
Sbjct: 983 VFTLVQ----------ERMCTEAPE----VCH--------------------LQEADVIF 1008
Query: 279 LIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDI 338
L DGS V +F + F+S ++D D+ + ++G+ Q+ S+ + L TK
Sbjct: 1009 LCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGSNYQSIIELKNSLTKTQW 1068
Query: 339 KAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
K ++N+S ALK + N F + +G R G + +V T G + + DA
Sbjct: 1069 KTQIQNVSKSGGFPRIDFALK-KVSNMFNLHAGGRRNAGVPQTLVVITSGDPRYDVADAV 1127
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIG--KKLQKKIC 452
K KDLG + +G+G+ ++ L I +E DF + + K++ ++IC
Sbjct: 1128 KTLKDLGICVLVLGIGDVYKEHLLPITGN--SEKIITFQDFDKLKNVDVKKRIIREIC 1183
Score = 119 bits (299), Expect = 5e-27
Identities = 98/414 (23%), Positives = 180/414 (43%), Gaps = 33/414 (7%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF+VDSS + P F VK F++++I SL + N RV + Y+ EF L
Sbjct: 30 DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89
Query: 101 KAALLQAVRR-IQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
++ +L +++ Q + G A+Q A F GR R +++V+ +D
Sbjct: 90 RSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRK-QFPPILVVLASAESED 148
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V++ S + GV++ ++GV + L+ +A+ H + + I LS Q
Sbjct: 149 EVEEASKALQKDGVKIISVGVQKASEENLKAMATS----HFHF--NLRTIRDLSTFSQNM 202
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
++ D+ + V + +C + S DLVFL
Sbjct: 203 TQIIKDVTKYKEG---AVDADMQVHFPISCQK-------------------DSLADLVFL 240
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
+D S N ++ F+ I ++DV + ++GL+ YS+S + L T+ + +
Sbjct: 241 VDESLGTGG-NLRHLQTFLENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQ 299
Query: 340 AAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAAK 397
++N+S + TGAA+ + + F+ S G+R G ++ ++ T S D ++DAA
Sbjct: 300 QQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAAL 359
Query: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
+ +FA+ + A +L EI S P + + + K KK+
Sbjct: 360 NLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTISTLKSYADLETYSTKFLKKL 413
Score = 86.3 bits (212), Expect = 6e-17
Identities = 99/432 (22%), Positives = 173/432 (40%), Gaps = 84/432 (19%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPN----ATRVGMVNYASTVK 90
C PT+LVF +D+S V F K + ++ ++ L++ N RV MV+Y S
Sbjct: 1752 CPAYPTELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTS 1811
Query: 91 QEFSLRAHVSKAALLQAVRRI--QPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKV 148
+ K LLQ + +I Q + G A++F F G + + +V
Sbjct: 1812 YLIRWSDYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAGAN----VRRV 1867
Query: 149 VIVVTDGRPQD-----------SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQD 197
+ ++G+ S D+S A +F G + T + I P
Sbjct: 1868 AVFFSNGQTASRSSIITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNG 1927
Query: 198 EHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNS 257
E+ +E+L R CA C C + AC L
Sbjct: 1928 EN-------QTLERLRR------------CAL----CYDKCFPN------ACIREAFLPE 1958
Query: 258 DGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLD------VSDKL 311
D S D+VFLID S+++ + F+ VK +S ++D + +SD
Sbjct: 1959 D-------------SYMDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFNIASDPLISDSG 2005
Query: 312 AQVGLVQYS---------SSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMT-GAALKYL 361
++ L+ YS +V+ EF + + +K ++ G T G AL +
Sbjct: 2006 DRIALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWT 2065
Query: 362 IDNSFTVSSGARPGAQKVGIVFTDGRS---QDYINDAAKKAKDLGFKMFAVGVGNAVEDE 418
+N F + R KV V + G + ++++ A +AK G+ +F + +G+ +D+
Sbjct: 2066 TENLFPETPYLR--KHKVIFVVSAGENYERKEFVKMMALRAKCQGYVIFVISLGSTRKDD 2123
Query: 419 LREIASEPVAEH 430
+ E+AS P+ +H
Sbjct: 2124 MEELASYPLDQH 2135
Score = 75.1 bits (183), Expect = 1e-13
Identities = 63/250 (25%), Positives = 109/250 (43%), Gaps = 22/250 (8%)
Query: 266 SGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQ 325
S G G D+VFL+D S + P++F VK FI++++++L + +V L QYS
Sbjct: 21 SPGPGPVYADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHS 80
Query: 326 EFPLGRFHTKKD-IKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQ--KVGIV 382
EF L F + + +N ++ G AL+ F+ R Q + +V
Sbjct: 81 EFHLSTFKGRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVV 140
Query: 383 FTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQ 442
S+D + +A+K + G K+ +VGV A E+ L+ +A+ + D T +Q
Sbjct: 141 LASAESEDEVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRTIRDLSTFSQ 200
Query: 443 IGKKLQKKI------CVEED-----PCACES--------LVKFQAKVEGLLQALTRKLEA 483
++ K + V+ D P +C+ LV G L+ L LE
Sbjct: 201 NMTQIIKDVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTGGNLRHLQTFLEN 260
Query: 484 VSKRLAILEN 493
++ + + EN
Sbjct: 261 ITSSMDVKEN 270
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/163 (22%), Positives = 74/163 (45%), Gaps = 2/163 (1%)
Query: 34 LCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEF 93
+C + D++F+ D S V +F + FLS +I++ D+ ++GM + S +
Sbjct: 998 VCHLQEADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGSNYQSII 1057
Query: 94 SLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVT 153
L+ ++K ++ + A++ ++ F GGR R+ + + ++V+T
Sbjct: 1058 ELKNSLTKTQWKTQIQNVSKSGGFPRIDFALK-KVSNMFNLHAGGR-RNAGVPQTLVVIT 1115
Query: 154 DGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQ 196
G P+ V D + G+ + +G+G V K L I +
Sbjct: 1116 SGDPRYDVADAVKTLKDLGICVLVLGIGDVYKEHLLPITGNSE 1158
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/179 (25%), Positives = 88/179 (49%), Gaps = 24/179 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD------VGPNATRVGMVNYA-------- 86
D+VF++D+SR++ EF+ VK +S VI++ + + + R+ +++Y+
Sbjct: 1963 DVVFLIDNSRNIAKDEFKAVKALVSSVIDNFNIASDPLISDSGDRIALLSYSPWESSRRK 2022
Query: 87 -STVKQEFSLRAHVSKAALLQAVR-RIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPD 144
TVK EF + ++ + ++ Q L+ G A+ + F + R
Sbjct: 2023 MGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWTTENLFPETPYLRKH--- 2079
Query: 145 ISKVVIVVTDG---RPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHV 200
KV+ VV+ G ++ V+ ++ RA+ G +F I +GS K + ++AS P D+H+
Sbjct: 2080 --KVIFVVSAGENYERKEFVKMMALRAKCQGYVIFVISLGSTRKDDMEELASYPLDQHL 2136
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 26/181 (14%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPN------ATRVGMVNYA-------- 86
D+ F++D+S+ V EF++VK F++ V++ + P RV +++Y+
Sbjct: 2291 DVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPNT 2350
Query: 87 --STVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPD 144
V EF L + S + ++ Q L+ G A+Q+ I F R
Sbjct: 2351 EECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQWTIDNVFVGTPNLRK---- 2406
Query: 145 ISKVVIVVTDGR----PQDSVQDVSARARASGVELFAIGVG-SVDKATLRQIASEPQDEH 199
+KV+ V++ G +D +++VS RA+ G +F G + L ++AS P D H
Sbjct: 2407 -NKVIFVISAGETNSLDKDVLRNVSLRAKCQGYSIFVFSFGPKHNDKELEELASHPLDHH 2465
Query: 200 V 200
+
Sbjct: 2466 L 2466
Score = 57.0 bits (136), Expect = 4e-08
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 27/179 (15%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLA------QVGLVQYSSS------ 322
D+ FLID S+ V + F+ VK FI+ ++D ++ +V ++ YS
Sbjct: 2291 DVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPNT 2350
Query: 323 ----VRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQK 378
V EF L +++ +K +++ + G AL++ IDN F P +K
Sbjct: 2351 EECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQWTIDNVFV----GTPNLRK 2406
Query: 379 VGIVF------TDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVED-ELREIASEPVAEH 430
++F T+ +D + + + +AK G+ +F G D EL E+AS P+ H
Sbjct: 2407 NKVIFVISAGETNSLDKDVLRNVSLRAKCQGYSIFVFSFGPKHNDKELEELASHPLDHH 2465
>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
Length = 2263
Score = 186 bits (471), Expect = 6e-47
Identities = 116/422 (27%), Positives = 208/422 (49%), Gaps = 51/422 (12%)
Query: 37 TRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLR 96
T D+ ++D S S + +F ++K FLS+V+ ++ P+ RVG V YA + EF +
Sbjct: 432 TEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEIN 491
Query: 97 AHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGR 156
+ +K L +A+ I+ + T TG A+ F ++ + + R + ++V+T+G
Sbjct: 492 KYSNKQDLGKAIENIRQMGGNTNTGAALNFTLSLL---QKAKKQRGNKVPCHLVVLTNGM 548
Query: 157 PQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKF 216
+DS+ + + R R + ++AIG+ ++ LR+IA E ++ V YV + ++ + +
Sbjct: 549 SKDSILEPANRLREEHIRVYAIGIKEANQTQLREIAGE--EKRVYYVHDFDALKDIRNQ- 605
Query: 217 QEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDL 276
VV ++C AC E D+
Sbjct: 606 -----VVQEICTEE-----------------ACKE--------------------MKADI 623
Query: 277 VFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKK 336
+FL+D S S+ PENF +K F+ +V + Q+G+VQ+S ++EF L RF ++
Sbjct: 624 MFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMSQS 683
Query: 337 DIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAA 396
DI A+ M+++ + T+TG+AL + + F+ + GARP +K I+ TDG +QD + + A
Sbjct: 684 DISNAIDQMAHIGQTTLTGSALSF-VSQYFSPTKGARPNIRKFLILITDGEAQDIVKEPA 742
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEED 456
+ G +++VGV + +L EI+ P E FY +F + +I L IC +
Sbjct: 743 VVLRQEGVIIYSVGVFGSNVTQLEEISGRP--EMVFYVENFDILQRIEDDLVFGICSPRE 800
Query: 457 PC 458
C
Sbjct: 801 EC 802
Score = 167 bits (424), Expect = 2e-41
Identities = 112/434 (25%), Positives = 210/434 (48%), Gaps = 54/434 (12%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++D S + F+ +K FL + + +LD+ N RVG+V Y++ K SL ++
Sbjct: 229 DVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGIN 288
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
K+ +LQ ++ + P + TG AI+ + K A G ++ + ++ ++VT +D+
Sbjct: 289 KSEVLQHIQNLSPRTGKAYTGAAIK-KLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDN 347
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESY--------SVIEKL 212
V + R GV +F +G+ L +IAS P +++V ++++ + ++KL
Sbjct: 348 VTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAAHNQTFLKKL 407
Query: 213 SRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSS 272
+ V S+ +T + SG +
Sbjct: 408 RNQITHTVSVFSE----------------------------------RTETLKSGCVDTE 433
Query: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRF 332
D+ LIDGS S + +F +K F+S++V +++ +VG VQY+ S EF + ++
Sbjct: 434 EADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKY 493
Query: 333 HTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVG---IVFTDGRSQ 389
K+D+ A+ N+ M T TGAAL + + + + KV +V T+G S+
Sbjct: 494 SNKQDLGKAIENIRQMGGNTNTGAALNFTLS---LLQKAKKQRGNKVPCHLVVLTNGMSK 550
Query: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQK 449
D I + A + ++ +++A+G+ A + +LREIA E + +Y DF + I ++ +
Sbjct: 551 DSILEPANRLREEHIRVYAIGIKEANQTQLREIAGE--EKRVYYVHDFDALKDIRNQVVQ 608
Query: 450 KICVEEDPCACESL 463
+IC EE AC+ +
Sbjct: 609 EICTEE---ACKEM 619
Score = 165 bits (417), Expect = 1e-40
Identities = 113/422 (26%), Positives = 207/422 (49%), Gaps = 54/422 (12%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFS 94
C+ D++F+VDSS S+ P F K+K F+ ++ +GP+ ++G+V ++ K+EF
Sbjct: 616 CKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQ 675
Query: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTD 154
L +S++ + A+ ++ + T+TG A+ F +++ F +G R P+I K +I++TD
Sbjct: 676 LNRFMSQSDISNAIDQMAHIGQTTLTGSALSF-VSQYFSPTKGAR---PNIRKFLILITD 731
Query: 155 GRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSR 214
G QD V++ + R GV ++++GV + L +I+ P E V YVE++ +++++
Sbjct: 732 GEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRP--EMVFYVENFDILQRIED 789
Query: 215 KFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSAT 274
+V +C+ + +C+++
Sbjct: 790 D------LVFGICSPRE-ECKRI----------------------------------EVL 808
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+VF+ID S S+ + + ++K F+ +V DV + G ++Y+ F L F T
Sbjct: 809 DVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFGT 868
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQ--D 390
K ++ + ++N M T T AL + D+ FT + G+R G +V IV TDG S D
Sbjct: 869 KLEVISVLQNDQAMGGSTYTAEALGF-SDHMFTEARGSRLNKGVPQVLIVITDGESHDAD 927
Query: 391 YINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKK 450
+N AK +D G + AVG+ A EL +A ++ YF+ F + I +
Sbjct: 928 KLNATAKALRDKGILVLAVGIDGANPVELLAMAGS--SDKYFFVETFGGLKGIFSDVTAS 985
Query: 451 IC 452
+C
Sbjct: 986 VC 987
Score = 162 bits (411), Expect = 5e-40
Identities = 126/467 (26%), Positives = 222/467 (47%), Gaps = 60/467 (12%)
Query: 17 LLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPN 76
L+ +CSP R R D+VFV+DSS S+ E+ +K F+ +++ DVG N
Sbjct: 791 LVFGICSP------REECKRIEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKN 844
Query: 77 ATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAE 136
R G + YA + F L +K ++ ++ Q + T T A+ F+ F +A
Sbjct: 845 QVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGSTYTAEALGFS-DHMFTEAR 903
Query: 137 GGRSRSPDISKVVIVVTDGRPQDSVQ-DVSARA-RASGVELFAIGVGSVDKATLRQIASE 194
G R + +V+IV+TDG D+ + + +A+A R G+ + A+G+ + L +A
Sbjct: 904 GSRLNK-GVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGS 962
Query: 195 PQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFT 254
+ +VE++ ++ + F + V + +C + DCE
Sbjct: 963 --SDKYFFVETFGGLKGI---FSD---VTASVCNSSKVDCE------------------- 995
Query: 255 LNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQV 314
DLVFL+DGS S++P +F+ +K+F++ +V DVS ++
Sbjct: 996 ----------------IDKVDLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRI 1039
Query: 315 GLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGAR- 373
G Q+S + EFPLG F +K+I + N+ + T GAAL+ +++ F G+R
Sbjct: 1040 GAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFGNTHIGAALRE-VEHYFRPDMGSRI 1098
Query: 374 -PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYF 432
G +V +V TDG+SQD + AA+ + G +++VG+G+ + +L +I AE
Sbjct: 1099 NTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGIGDVDDQQLIQITG--TAEKKL 1156
Query: 433 YTADFKTINQIGKKLQKKICVE--EDPCACESLVKFQAKVEGLLQAL 477
+F + ++ K++ + IC E C + +V F + Q L
Sbjct: 1157 TVHNFDELKKVNKRIVRNICTTAGESNCFVDVVVGFDVSTQEKGQTL 1203
Score = 137 bits (346), Expect = 2e-32
Identities = 115/446 (25%), Positives = 201/446 (45%), Gaps = 46/446 (10%)
Query: 14 LLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDV 73
L+L L +CS Q G D+VF+VDSS + F VK+F++++I SL +
Sbjct: 4 LILFLVIICSHISVNQDSG----PEYADVVFLVDSSDRLGSKSFPFVKMFITKMISSLPI 59
Query: 74 GPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT-GLAIQFAITKAF 132
+ RV + Y+ + EF L ++ +L +R+ G++ G A+Q A F
Sbjct: 60 EADKYRVALAQYSDKLHSEFHLSTFKGRSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYF 119
Query: 133 GDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIA 192
GR + +++V+ +D+V++ S R GV++ ++GV + L+ +A
Sbjct: 120 SAPANGRDKK-QFPPILVVLASSESEDNVEEASKALRKDGVKIISVGVQKASEENLKAMA 178
Query: 193 SEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEG 252
+ + + + LS Q ++ D+ + + + + AC
Sbjct: 179 TS------QFHFNLRTVRDLSMFSQNMTHIIKDVIKYKEGAVDDIFVE-------ACQ-- 223
Query: 253 FTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLA 312
G S D+VFL+D S + ENF+ +K F+ + V LD+ +
Sbjct: 224 -----------------GPSMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCM 266
Query: 313 QVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGA 372
+VGLV YS+ + L K ++ ++N+S TGAA+K L F+ +G+
Sbjct: 267 RVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGS 326
Query: 373 R--PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEH 430
R G ++ ++ T S+D + AA + G +F +G+ A + +L +IAS P AE
Sbjct: 327 RKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHP-AEQ 385
Query: 431 YFYT----ADFKTINQ-IGKKLQKKI 451
Y AD NQ KKL+ +I
Sbjct: 386 YVSKLKTFADLAAHNQTFLKKLRNQI 411
Score = 77.0 bits (188), Expect = 4e-14
Identities = 98/436 (22%), Positives = 175/436 (40%), Gaps = 86/436 (19%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVG----MVNYASTVK 90
C PT+LVF +D SR V EFE++K ++ ++ + V N+ VG +++Y S +
Sbjct: 1751 CPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHAR 1810
Query: 91 QEFSLRAHVSKAALLQAVRRI--QPLSTGTMTGLAIQFAITKAFGDA-EGGRSRSPDISK 147
K+ LL+ + I + S G A++F F G +R K
Sbjct: 1811 HLVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTLPGAHTR-----K 1865
Query: 148 VVIVVTDGRPQDSVQDVSARARASGVELFAIGVG-----------SVDKATLRQIASEPQ 196
+ + G+ D+ +A +E+ + + ++D Q+ P
Sbjct: 1866 IATFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPS 1925
Query: 197 DEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLN 256
DY+ + +E+L R FC D+C D C+Q SY
Sbjct: 1926 G--ADYIPA---LERLQRC---TFCY--DVCKP-DASCDQARPPPVQSYM---------- 1964
Query: 257 SDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLA---- 312
D FL+D S+++ FE ++ F+ ++D +++ +
Sbjct: 1965 ------------------DAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVT 2006
Query: 313 --QVGLVQYS----------SSVRQEFPLGRFHTKKDIKAAV-RNMSYMEKGTMTGAALK 359
+V L+ ++ S VR EF L + +K+ +K V ++ + G AL+
Sbjct: 2007 GDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQ 2066
Query: 360 YLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKK----AKDLGFKMFAVGVGNAV 415
+ +DN F + R KV V + G + + KK AK G+ +F +G
Sbjct: 2067 WTLDNVFLSTPNLR--RNKVIFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIW 2124
Query: 416 ED-ELREIASEPVAEH 430
+D EL ++AS P+ H
Sbjct: 2125 DDKELEDLASHPLDHH 2140
Score = 60.8 bits (146), Expect = 3e-09
Identities = 46/182 (25%), Positives = 85/182 (46%), Gaps = 27/182 (14%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGP------NATRVGMVNYA-------- 86
D F++D+SR++ EFE ++ FL +++ ++ P RV ++++A
Sbjct: 1965 DAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNT 2024
Query: 87 --STVKQEFSLRAHVSKAALLQAVRR-IQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSP 143
S V+ EF+L + SK + + V ++ L+ G A+Q+ + F R
Sbjct: 2025 QKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRR--- 2081
Query: 144 DISKVVIVVTDGRPQ----DSVQDVSARARASGVELFAIGVGSV-DKATLRQIASEPQDE 198
+KV+ V++ G + ++ S RA+ G LF +G + D L +AS P D
Sbjct: 2082 --NKVIFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDDKELEDLASHPLDH 2139
Query: 199 HV 200
H+
Sbjct: 2140 HL 2141
>gi|21359974 vitrin [Homo sapiens]
Length = 693
Score = 184 bits (466), Expect = 2e-46
Identities = 132/459 (28%), Positives = 215/459 (46%), Gaps = 61/459 (13%)
Query: 8 SLMLCSLLLLLQALCSPGLAPQSRGHL-CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQ 66
S++L L+ + L + L P S G C+ DL F++D S S+ F K L+
Sbjct: 277 SVLLDEGLVPKEELSTQSLEPVSLGDPNCKI---DLSFLIDGSTSIGKRRFRIQKQLLAD 333
Query: 67 VIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQF 126
V ++LD+GP +G+V Y F+L+ H + L A+ +I + G AI F
Sbjct: 334 VAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGGLSNVGRAISF 393
Query: 127 AITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV-GSVDK 185
F A G RS +P+ VV+V+ DG P D V++ S AR SG+ +F I + G+ +
Sbjct: 394 VTKNFFSKANGNRSGAPN---VVVVMVDGWPTDKVEEASRLARESGINIFFITIEGAAEN 450
Query: 186 ATLRQIASEPQDEHVD----------YVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCE 235
+Q EP + +V+S+ + K + +V +C T C
Sbjct: 451 E--KQYVVEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQP------LVKRVCDTDRLACS 502
Query: 236 QVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVK 295
+ C++S D+ F+IDGS SV NF V
Sbjct: 503 KTCLNS--------------------------------ADIGFVIDGSSSVGTGNFRTVL 530
Query: 296 KFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTG 355
+F++ + ++SD ++G VQY+ R EF ++ +K DI A++ + Y GT TG
Sbjct: 531 QFVTNLTKEFEISDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSGGTSTG 590
Query: 356 AALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAV 415
AA+ + ++ F S +P +K+ I+ TDGRS D + A A G +A+GV A
Sbjct: 591 AAINFALEQLFKKS---KPNKRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAA 647
Query: 416 EDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVE 454
++EL IA+ P +H F+ +F ++Q ++ + IC E
Sbjct: 648 QEELEVIATHPARDHSFFVDEFDNLHQYVPRIIQNICTE 686
Score = 86.7 bits (213), Expect = 5e-17
Identities = 54/202 (26%), Positives = 98/202 (48%), Gaps = 10/202 (4%)
Query: 268 GGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEF 327
G + DL FLIDGS S+ F + K+ ++ + LD+ +G+VQY + F
Sbjct: 301 GDPNCKIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHF 360
Query: 328 PLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGR 387
L +D+K A+ ++ + G A+ ++ N F+ ++G R GA V +V DG
Sbjct: 361 NLKTHTNSRDLKTAIEKITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPNVVVVMVDGW 420
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAE------HYFYTADFKTIN 441
D + +A++ A++ G +F + + A E+E + + A + FY+ ++
Sbjct: 421 PTDKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWF 480
Query: 442 QIGKKLQ---KKICVEEDPCAC 460
+ K LQ K++C + D AC
Sbjct: 481 GLHKTLQPLVKRVC-DTDRLAC 501
>gi|205277471 cochlin precursor [Homo sapiens]
Length = 550
Score = 160 bits (404), Expect = 3e-39
Identities = 118/428 (27%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+ F++D S ++ F K F+ +V L +G VG+V + K EF L+ S
Sbjct: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
+L A++ + + TG A++ K F G R P KVV+V DG P D
Sbjct: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIP---KVVVVFIDGWPSDD 281
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAF 220
+++ AR GV +F + V ++P E + V+ + ++K + F
Sbjct: 282 IEEAGIVAREFGVNVFIVSV------------AKPIPEELGMVQDVTFVDKAVCRNNGFF 329
Query: 221 C---------------VVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVC 265
+V LC C + C +S
Sbjct: 330 SYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNS------------------------ 365
Query: 266 SGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQ 325
++ FLIDGS SV NF L+ +F+S I T ++SD A++ VQ++ R
Sbjct: 366 --------VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
Query: 326 EFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQK-VGIVFT 384
EF + TK+++ A +RN+ YM GT TG A+ + + N F R K ++ T
Sbjct: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVT 474
Query: 385 DGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIG 444
DG+S D + A A D G +F+VGV A D+L+++AS+P H F+T +F + I
Sbjct: 475 DGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIV 534
Query: 445 KKLQKKIC 452
+ + IC
Sbjct: 535 SDVIRGIC 542
Score = 97.1 bits (240), Expect = 3e-20
Identities = 67/232 (28%), Positives = 107/232 (46%), Gaps = 15/232 (6%)
Query: 190 QIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSP--GSYTC 247
++ S P E+ V++ + ++ ++ +F V +T + + V + P G
Sbjct: 91 RVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLK 150
Query: 248 ACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDV 307
E T N D K D+ FLIDGS ++ F L K F+ ++ L +
Sbjct: 151 KTPEKKTGNKDCKA-------------DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
Query: 308 SDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFT 367
+ VGLVQ S + EF L F + KD+ A++ + + + TG ALK+ FT
Sbjct: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFT 257
Query: 368 VSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDEL 419
V +G R G KV +VF DG D I +A A++ G +F V V + +EL
Sbjct: 258 VDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
>gi|4758022 cochlin precursor [Homo sapiens]
Length = 550
Score = 160 bits (404), Expect = 3e-39
Identities = 118/428 (27%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+ F++D S ++ F K F+ +V L +G VG+V + K EF L+ S
Sbjct: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
+L A++ + + TG A++ K F G R P KVV+V DG P D
Sbjct: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIP---KVVVVFIDGWPSDD 281
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAF 220
+++ AR GV +F + V ++P E + V+ + ++K + F
Sbjct: 282 IEEAGIVAREFGVNVFIVSV------------AKPIPEELGMVQDVTFVDKAVCRNNGFF 329
Query: 221 C---------------VVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVC 265
+V LC C + C +S
Sbjct: 330 SYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNS------------------------ 365
Query: 266 SGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQ 325
++ FLIDGS SV NF L+ +F+S I T ++SD A++ VQ++ R
Sbjct: 366 --------VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
Query: 326 EFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQK-VGIVFT 384
EF + TK+++ A +RN+ YM GT TG A+ + + N F R K ++ T
Sbjct: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVT 474
Query: 385 DGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIG 444
DG+S D + A A D G +F+VGV A D+L+++AS+P H F+T +F + I
Sbjct: 475 DGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIV 534
Query: 445 KKLQKKIC 452
+ + IC
Sbjct: 535 SDVIRGIC 542
Score = 97.1 bits (240), Expect = 3e-20
Identities = 67/232 (28%), Positives = 107/232 (46%), Gaps = 15/232 (6%)
Query: 190 QIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSP--GSYTC 247
++ S P E+ V++ + ++ ++ +F V +T + + V + P G
Sbjct: 91 RVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLK 150
Query: 248 ACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDV 307
E T N D K D+ FLIDGS ++ F L K F+ ++ L +
Sbjct: 151 KTPEKKTGNKDCKA-------------DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
Query: 308 SDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFT 367
+ VGLVQ S + EF L F + KD+ A++ + + + TG ALK+ FT
Sbjct: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFT 257
Query: 368 VSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDEL 419
V +G R G KV +VF DG D I +A A++ G +F V V + +EL
Sbjct: 258 VDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
Length = 1626
Score = 160 bits (404), Expect = 3e-39
Identities = 86/199 (43%), Positives = 127/199 (63%), Gaps = 12/199 (6%)
Query: 266 SGGGGSSAT---------DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGL 316
SGGGG A DLVFL+D S SV E+FE V+++++ +VDT +V +VG+
Sbjct: 20 SGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGV 79
Query: 317 VQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP-- 374
V+YS F LG F +++++KAA R ++Y T TG AL+Y+ SF+ +G RP
Sbjct: 80 VRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRD 139
Query: 375 -GAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFY 433
++V I+ TDGRSQD + DAA A G ++FAVGVG A+++EL EIASEP + H F+
Sbjct: 140 RAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFH 199
Query: 434 TADFKTINQIGKKLQKKIC 452
+DF I++I KL++++C
Sbjct: 200 VSDFNAIDKIRGKLRRRLC 218
Score = 137 bits (344), Expect = 3e-32
Identities = 75/207 (36%), Positives = 120/207 (57%)
Query: 15 LLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVG 74
LL + L S G Q++ C++ DLVF++D+S SV +FEKV+ +++ ++++ +VG
Sbjct: 12 LLWMLLLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVG 71
Query: 75 PNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGD 134
P+ TRVG+V Y+ F L S+ + A RR+ T TG A+++ ++F
Sbjct: 72 PDRTRVGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSP 131
Query: 135 AEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASE 194
GGR R +V I++TDGR QD V D +A A +G+ +FA+GVG K L +IASE
Sbjct: 132 HAGGRPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASE 191
Query: 195 PQDEHVDYVESYSVIEKLSRKFQEAFC 221
P+ HV +V ++ I+K+ K + C
Sbjct: 192 PKSAHVFHVSDFNAIDKIRGKLRRRLC 218
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 157 bits (396), Expect = 3e-38
Identities = 113/388 (29%), Positives = 192/388 (49%), Gaps = 36/388 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++DSS VRP F ++ F+S+++ L++GP+ RVG+V +++ V EF L+ + S
Sbjct: 1230 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 1289
Query: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
+A +L A+RR++ + TG A++F F + G R + + +++V G+ QD
Sbjct: 1290 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIED-GVPQHLVLVLGGKSQD 1348
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V + R+SG+ +G ++D+ L+ I ++P+ V V + + + + +
Sbjct: 1349 DVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR--LVFTVREFRELPNIEERIMNS 1406
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
F P + T A G + D+VFL
Sbjct: 1407 F--------------------GPSAATPA-PPGVDTPPPSRP--------EKKKADIVFL 1437
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
+DGS + R ++F+ V +F+S+IVDT+ QVGLVQY+S EF L F TK+ I
Sbjct: 1438 LDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQII 1497
Query: 340 AAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
A+ + Y + T L++L N F +G+R ++ V T G+S + D +
Sbjct: 1498 DAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVS 1557
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIAS 424
G K+FAVGV N +E+ +IAS
Sbjct: 1558 LALTQRGVKVFAVGVRNIDSEEVGKIAS 1585
Score = 145 bits (366), Expect = 8e-35
Identities = 123/451 (27%), Positives = 215/451 (47%), Gaps = 50/451 (11%)
Query: 2 RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61
RV T L L +LQ L SPG+ + D+VF++D S+S P EF+ V+
Sbjct: 998 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 1046
Query: 62 VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT- 120
+ ++++ LDVG + TRV ++ ++ K EF L AH SK + AV+R++P +
Sbjct: 1047 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 1106
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
G A+++ F G R + + +++++ G+ D V D + + GV F I
Sbjct: 1107 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA- 1164
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVC-I 239
+ D+ L +I+ P+ YV S S +L Q+ ++ L + EQ+ +
Sbjct: 1165 RNADQEELVKISLSPE-----YVFSVSTFRELPSLEQKLLTPITTLTS------EQIQKL 1213
Query: 240 SSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFIS 299
+ Y E S A D+VFLID S+ VRP+ F ++ F+S
Sbjct: 1214 LASTRYPPPAVE-------------------SDAADIVFLIDSSEGVRPDGFAHIRDFVS 1254
Query: 300 QIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTM-TGAAL 358
+IV L++ +VG+VQ+S+ V EF L + ++ + A+R + + TG AL
Sbjct: 1255 RIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKAL 1314
Query: 359 KYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVE 416
+++ N F S+G+R G + ++ G+SQD ++ A+ + G VG N
Sbjct: 1315 EFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDR 1374
Query: 417 DELREIASEPVAEHYFYTADFKTINQIGKKL 447
EL+ I ++P F +F+ + I +++
Sbjct: 1375 TELQTITNDP--RLVFTVREFRELPNIEERI 1403
Score = 142 bits (359), Expect = 5e-34
Identities = 108/403 (26%), Positives = 191/403 (47%), Gaps = 40/403 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S + V F + FL ++E L +G RVG+V ++ + FSL + +
Sbjct: 36 DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
KA +L AV+ + + G + GLA+ F + F A G R + +V+++++ G
Sbjct: 96 KAQVLGAVKALG-FAGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 153
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D ++ + + V F +G + +A L+ IA++ D V V + L K
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKLLP 211
Query: 219 AFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVF 278
V+ + + P T + D+VF
Sbjct: 212 YIVGVAQ---------RHIVLKPPTIVTQVIEV--------------------NKRDIVF 242
Query: 279 LIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDI 338
L+DGS ++ NF ++ FI++++ L++ L QV + QY+ +VR EF TK+++
Sbjct: 243 LVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREV 302
Query: 339 KAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDYINDA 395
AVR M ++ + TG+AL ++ +N FT S+G A G K+ ++ T G+S D I+
Sbjct: 303 ITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQP 362
Query: 396 AKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438
A++ K FA+G A + EL EIA + + F A+F+
Sbjct: 363 AQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 403
Score = 132 bits (333), Expect = 6e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F+ D S ++ +F V+ FL ++I+ L+V P TR+ + Y+ VK E H S
Sbjct: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
K +L V+R++ + TG G A+ +A F + G R + +V++V GR
Sbjct: 690 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 747
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V ++ + SGV F + D A L QI P
Sbjct: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 784
Query: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277
AF + ++ L GD + V + + H G G+ D+V
Sbjct: 785 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 825
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+DGS+ VR F L+K+F+ ++V++LDV +V +VQYS R EF L + K+D
Sbjct: 826 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 884
Query: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
+ AVR ++ + T TGAAL++++ N S+G+R G ++ IV T RS D + +
Sbjct: 885 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 944
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
+ K G +G+GNA E++ I+ P
Sbjct: 945 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
Score = 129 bits (325), Expect = 5e-30
Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S +V F V+ F+ ++ SLD+G + RVG+V ++ T EFSL + +
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K+ +L +R++Q +G TG A+ + F +A G R R + ++++++T G+ +D
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 551
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
S + +G+ F +G +KA L QIA P V ++ +S + L ++
Sbjct: 552 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 605
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
++ L E+V ++ P S D++FL
Sbjct: 606 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 635
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
DGS ++ + F +V+ F+ +I+D L+V + ++ + QYS V+ E +K +I
Sbjct: 636 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 694
Query: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
V+ M K G AL Y F S+G+R G + ++ GRS D ++ A
Sbjct: 695 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 754
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426
K G F NA EL +I P
Sbjct: 755 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+ D++FL+DGS +V NF V+ F+ +V++LD+ + +VGLVQ+S + EF L
Sbjct: 429 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 488
Query: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387
+ TK DI +R + G TG+AL Y+ N FT + G+ R ++ ++ T G+
Sbjct: 489 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
S+D AA G F VG A + EL +IA P + DF ++ + ++L
Sbjct: 549 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 606
Query: 448 QKKIC------VEEDPCA 459
+ + VEE P A
Sbjct: 607 IQPLTTYVSGGVEEVPLA 624
Score = 77.0 bits (188), Expect = 4e-14
Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 5/178 (2%)
Query: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRF 332
+ D++FLIDGS + NF ++ F+ +++ L + + +VG+VQ+S R F L +
Sbjct: 34 SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
Query: 333 HTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQ 389
TK + AV+ + + + G AL ++++N FT + G+R G +V ++ + G S
Sbjct: 94 STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
Query: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
D I K F +G A EL+ IA++ F +F++ + +KL
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDD--NLVFTVPEFRSFGDLQEKL 209
Score = 74.7 bits (182), Expect = 2e-13
Identities = 103/452 (22%), Positives = 182/452 (40%), Gaps = 80/452 (17%)
Query: 38 RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRA 97
+ D+VF++D S + R F++V F+S++++++ ++ +VG+V Y S EF L+
Sbjct: 1430 KKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKD 1489
Query: 98 HVSKAALLQAVRR-IQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGR 156
+K ++ A+ + + T + ++ F E G + ++ V+T G+
Sbjct: 1490 FSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF-VPEAGSRLDQRVPQIAFVITGGK 1548
Query: 157 PQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKF 216
+ QDVS GV++FA+GV ++D + +IAS V + + +LS +
Sbjct: 1549 SVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAF--RVGNVQELSELSEQV 1606
Query: 217 QEAFCVVSDLCATGDHDC--EQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSAT 274
E HD E +C PG + K CN+
Sbjct: 1607 LETL-----------HDAMHETLC---PG-----------VTDAAKACNL---------- 1631
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSS--------SVRQE 326
D++ DGS R +N + +K VD + ++++Q+ V S SV
Sbjct: 1632 DVILGFDGS---RDQNVFVAQKGFESKVDA--ILNRISQMHRVSCSGGRSPTVRVSVVAN 1686
Query: 327 FPLGRFHT------KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVG 380
P G + ++ RNM +T LK + N F SS P + KV
Sbjct: 1687 TPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYL-NKFRQSS---PDSVKVV 1742
Query: 381 IVFTDGRSQDY--INDAAKKAKDLGFK-MFAVGVGNAVEDELREIASEPVAEHYFY---- 433
I FTDG D ++ A++ + G + + VG+ V L + + Y
Sbjct: 1743 IHFTDGADGDLADLHRASENLRQEGVRALILVGLERVV--NLERLMHLEFGRGFMYDRPL 1800
Query: 434 -----TADFKTINQIGKKLQKKICVEEDPCAC 460
D++ Q+ +K C PC C
Sbjct: 1801 RLNLLDLDYELAEQLDNIAEKACC--GVPCKC 1830
Score = 70.9 bits (172), Expect = 3e-12
Identities = 98/451 (21%), Positives = 178/451 (39%), Gaps = 61/451 (13%)
Query: 6 GTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLS 65
G S+ C+L+ ++ C P C PT+L F +D+S V F +++ +
Sbjct: 2165 GDSIDQCALIQSIKDKCPCCYGPLE----CPVFPTELAFALDTSEGVNQDTFGRMRDVVL 2220
Query: 66 QVIESLDVG----PNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTG 121
++ L + P RV +V Y + V E K+ LL ++ +Q T
Sbjct: 2221 SIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQS 2280
Query: 122 L--AIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIG 179
L A+ F F R R+ + + V V P + S + R + ++L G
Sbjct: 2281 LETAMSFVARNTFK-----RVRNGFLMRKVAVFFSNTPTRA----SPQLREAVLKLSDAG 2331
Query: 180 VGSV--DKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQV 237
+ + + RQ+ + Q + ++++ R + V H C +
Sbjct: 2332 ITPLFLTRQEDRQLINALQINNT--AVGHALVLPAGRDLTDFLENVLTC-----HVCLDI 2384
Query: 238 CISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKF 297
C P + F G D+ F++D +++ F +KK+
Sbjct: 2385 CNIDPSCGFGSWRPSFRDRR---------AAGSDVDIDMAFILDSAETTTLFQFNEMKKY 2435
Query: 298 ISQIVDTLDV------SDKLAQVGLVQYSSS----------VRQEFPLGRFHTK-KDIKA 340
I+ +V LD+ S A+V +VQ++ S V+ EF L + +K K +
Sbjct: 2436 IAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDF 2495
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKK-- 398
R M+ ++ G+A++Y I+N F S P K+ ++ G + + A++
Sbjct: 2496 LSRGMTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVI 2553
Query: 399 --AKDLGFKMFAVGVGNAVE-DELREIASEP 426
AK G+ +G+G V E+ ASEP
Sbjct: 2554 LQAKCKGYFFVVLGIGRKVNIKEVYTFASEP 2584
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/178 (27%), Positives = 84/178 (47%), Gaps = 25/178 (14%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNA------TRVGMVNYAST------ 88
D+ F++DS+ + +F ++K +++ ++ LD+ P+ RV +V +A +
Sbjct: 2413 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2472
Query: 89 ----VKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT-GLAIQFAITKAFGDAEGGRSRSP 143
VK EFSL + SK L+ + R GT G AI++ I F A R
Sbjct: 2473 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR---- 2528
Query: 144 DISKVVIVVTDGRPQ---DSVQDVSARARASGVELFAIGVG-SVDKATLRQIASEPQD 197
D+ VV+++T P+ + Q V +A+ G +G+G V+ + ASEP D
Sbjct: 2529 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPND 2586
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 157 bits (396), Expect = 3e-38
Identities = 113/388 (29%), Positives = 192/388 (49%), Gaps = 36/388 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++DSS VRP F ++ F+S+++ L++GP+ RVG+V +++ V EF L+ + S
Sbjct: 1436 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 1495
Query: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
+A +L A+RR++ + TG A++F F + G R + + +++V G+ QD
Sbjct: 1496 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIED-GVPQHLVLVLGGKSQD 1554
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V + R+SG+ +G ++D+ L+ I ++P+ V V + + + + +
Sbjct: 1555 DVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR--LVFTVREFRELPNIEERIMNS 1612
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
F P + T A G + D+VFL
Sbjct: 1613 F--------------------GPSAATPA-PPGVDTPPPSRP--------EKKKADIVFL 1643
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
+DGS + R ++F+ V +F+S+IVDT+ QVGLVQY+S EF L F TK+ I
Sbjct: 1644 LDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQII 1703
Query: 340 AAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
A+ + Y + T L++L N F +G+R ++ V T G+S + D +
Sbjct: 1704 DAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVS 1763
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIAS 424
G K+FAVGV N +E+ +IAS
Sbjct: 1764 LALTQRGVKVFAVGVRNIDSEEVGKIAS 1791
Score = 149 bits (375), Expect = 7e-36
Identities = 110/424 (25%), Positives = 195/424 (45%), Gaps = 36/424 (8%)
Query: 27 APQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYA 86
A Q + + D++F+VDSS ++ F+ V+ FL V++SL VG N +V +
Sbjct: 25 AQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFN 84
Query: 87 STVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDIS 146
EF L + +K +L + + + TG +++ + A G R+ +
Sbjct: 85 GNPHTEFLLNTYRTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRA-GDGVP 143
Query: 147 KVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESY 206
+V++V+TDG +D + SA +++ V +FAIGV D+ L++IASEP + H+ +E++
Sbjct: 144 QVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFNLENF 203
Query: 207 SVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCS 266
T HD G+ H + G T +
Sbjct: 204 ----------------------TSLHDI-------VGNLVSCVHSSVSPERAGDTETLKD 234
Query: 267 GGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQE 326
SA D++FLIDGS + NF ++ F+ +++ L + + +VG+VQ+S R
Sbjct: 235 ITAQDSA-DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTM 293
Query: 327 FPLGRFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVF 383
F L + TK + AV+ + + + G AL ++++N FT + G+R G +V ++
Sbjct: 294 FSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLI 353
Query: 384 TDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQI 443
+ G S D I K F +G A EL+ IA++ F +F++ +
Sbjct: 354 SAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDD--NLVFTVPEFRSFGDL 411
Query: 444 GKKL 447
+KL
Sbjct: 412 QEKL 415
Score = 145 bits (366), Expect = 8e-35
Identities = 123/451 (27%), Positives = 215/451 (47%), Gaps = 50/451 (11%)
Query: 2 RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61
RV T L L +LQ L SPG+ + D+VF++D S+S P EF+ V+
Sbjct: 1204 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 1252
Query: 62 VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT- 120
+ ++++ LDVG + TRV ++ ++ K EF L AH SK + AV+R++P +
Sbjct: 1253 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 1312
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
G A+++ F G R + + +++++ G+ D V D + + GV F I
Sbjct: 1313 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA- 1370
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVC-I 239
+ D+ L +I+ P+ YV S S +L Q+ ++ L + EQ+ +
Sbjct: 1371 RNADQEELVKISLSPE-----YVFSVSTFRELPSLEQKLLTPITTLTS------EQIQKL 1419
Query: 240 SSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFIS 299
+ Y E S A D+VFLID S+ VRP+ F ++ F+S
Sbjct: 1420 LASTRYPPPAVE-------------------SDAADIVFLIDSSEGVRPDGFAHIRDFVS 1460
Query: 300 QIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTM-TGAAL 358
+IV L++ +VG+VQ+S+ V EF L + ++ + A+R + + TG AL
Sbjct: 1461 RIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKAL 1520
Query: 359 KYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVE 416
+++ N F S+G+R G + ++ G+SQD ++ A+ + G VG N
Sbjct: 1521 EFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDR 1580
Query: 417 DELREIASEPVAEHYFYTADFKTINQIGKKL 447
EL+ I ++P F +F+ + I +++
Sbjct: 1581 TELQTITNDP--RLVFTVREFRELPNIEERI 1609
Score = 142 bits (359), Expect = 5e-34
Identities = 108/403 (26%), Positives = 191/403 (47%), Gaps = 40/403 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S + V F + FL ++E L +G RVG+V ++ + FSL + +
Sbjct: 242 DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 301
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
KA +L AV+ + + G + GLA+ F + F A G R + +V+++++ G
Sbjct: 302 KAQVLGAVKALG-FAGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 359
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D ++ + + V F +G + +A L+ IA++ D V V + L K
Sbjct: 360 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKLLP 417
Query: 219 AFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVF 278
V+ + + P T + D+VF
Sbjct: 418 YIVGVAQ---------RHIVLKPPTIVTQVIEV--------------------NKRDIVF 448
Query: 279 LIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDI 338
L+DGS ++ NF ++ FI++++ L++ L QV + QY+ +VR EF TK+++
Sbjct: 449 LVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREV 508
Query: 339 KAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDYINDA 395
AVR M ++ + TG+AL ++ +N FT S+G A G K+ ++ T G+S D I+
Sbjct: 509 ITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQP 568
Query: 396 AKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438
A++ K FA+G A + EL EIA + + F A+F+
Sbjct: 569 AQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 609
Score = 132 bits (333), Expect = 6e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F+ D S ++ +F V+ FL ++I+ L+V P TR+ + Y+ VK E H S
Sbjct: 837 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 895
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
K +L V+R++ + TG G A+ +A F + G R + +V++V GR
Sbjct: 896 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 953
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V ++ + SGV F + D A L QI P
Sbjct: 954 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 990
Query: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277
AF + ++ L GD + V + + H G G+ D+V
Sbjct: 991 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 1031
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+DGS+ VR F L+K+F+ ++V++LDV +V +VQYS R EF L + K+D
Sbjct: 1032 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 1090
Query: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
+ AVR ++ + T TGAAL++++ N S+G+R G ++ IV T RS D + +
Sbjct: 1091 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 1150
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
+ K G +G+GNA E++ I+ P
Sbjct: 1151 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 1182
Score = 129 bits (325), Expect = 5e-30
Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S +V F V+ F+ ++ SLD+G + RVG+V ++ T EFSL + +
Sbjct: 639 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 698
Query: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K+ +L +R++Q +G TG A+ + F +A G R R + ++++++T G+ +D
Sbjct: 699 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 757
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
S + +G+ F +G +KA L QIA P V ++ +S + L ++
Sbjct: 758 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 811
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
++ L E+V ++ P S D++FL
Sbjct: 812 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 841
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
DGS ++ + F +V+ F+ +I+D L+V + ++ + QYS V+ E +K +I
Sbjct: 842 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 900
Query: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
V+ M K G AL Y F S+G+R G + ++ GRS D ++ A
Sbjct: 901 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 960
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426
K G F NA EL +I P
Sbjct: 961 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 990
Score = 113 bits (283), Expect = 3e-25
Identities = 65/200 (32%), Positives = 116/200 (58%), Gaps = 7/200 (3%)
Query: 247 CACHEGF-TLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTL 305
C GF T ++ + +V +G +A D++FL+D S ++ E+F+LV++F+ +V +L
Sbjct: 14 CLFLSGFPTTHAQQQQADVKNG----AAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSL 69
Query: 306 DVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNS 365
V + LVQ++ + EF L + TK+++ + + NMSY+ TG L+Y++ +
Sbjct: 70 AVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSH 129
Query: 366 FTVSSGAR--PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIA 423
T ++G+R G +V +V TDG S+D + + + K +FA+GV +A E L+EIA
Sbjct: 130 LTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIA 189
Query: 424 SEPVAEHYFYTADFKTINQI 443
SEP+ H F +F +++ I
Sbjct: 190 SEPLNMHMFNLENFTSLHDI 209
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+ D++FL+DGS +V NF V+ F+ +V++LD+ + +VGLVQ+S + EF L
Sbjct: 635 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 694
Query: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387
+ TK DI +R + G TG+AL Y+ N FT + G+ R ++ ++ T G+
Sbjct: 695 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 754
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
S+D AA G F VG A + EL +IA P + DF ++ + ++L
Sbjct: 755 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 812
Query: 448 QKKIC------VEEDPCA 459
+ + VEE P A
Sbjct: 813 IQPLTTYVSGGVEEVPLA 830
Score = 74.7 bits (182), Expect = 2e-13
Identities = 103/452 (22%), Positives = 182/452 (40%), Gaps = 80/452 (17%)
Query: 38 RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRA 97
+ D+VF++D S + R F++V F+S++++++ ++ +VG+V Y S EF L+
Sbjct: 1636 KKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKD 1695
Query: 98 HVSKAALLQAVRR-IQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGR 156
+K ++ A+ + + T + ++ F E G + ++ V+T G+
Sbjct: 1696 FSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF-VPEAGSRLDQRVPQIAFVITGGK 1754
Query: 157 PQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKF 216
+ QDVS GV++FA+GV ++D + +IAS V + + +LS +
Sbjct: 1755 SVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAF--RVGNVQELSELSEQV 1812
Query: 217 QEAFCVVSDLCATGDHDC--EQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSAT 274
E HD E +C PG + K CN+
Sbjct: 1813 LETL-----------HDAMHETLC---PG-----------VTDAAKACNL---------- 1837
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSS--------SVRQE 326
D++ DGS R +N + +K VD + ++++Q+ V S SV
Sbjct: 1838 DVILGFDGS---RDQNVFVAQKGFESKVDA--ILNRISQMHRVSCSGGRSPTVRVSVVAN 1892
Query: 327 FPLGRFHT------KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVG 380
P G + ++ RNM +T LK + N F SS P + KV
Sbjct: 1893 TPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYL-NKFRQSS---PDSVKVV 1948
Query: 381 IVFTDGRSQDY--INDAAKKAKDLGFK-MFAVGVGNAVEDELREIASEPVAEHYFY---- 433
I FTDG D ++ A++ + G + + VG+ V L + + Y
Sbjct: 1949 IHFTDGADGDLADLHRASENLRQEGVRALILVGLERVV--NLERLMHLEFGRGFMYDRPL 2006
Query: 434 -----TADFKTINQIGKKLQKKICVEEDPCAC 460
D++ Q+ +K C PC C
Sbjct: 2007 RLNLLDLDYELAEQLDNIAEKACC--GVPCKC 2036
Score = 70.9 bits (172), Expect = 3e-12
Identities = 98/451 (21%), Positives = 178/451 (39%), Gaps = 61/451 (13%)
Query: 6 GTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLS 65
G S+ C+L+ ++ C P C PT+L F +D+S V F +++ +
Sbjct: 2371 GDSIDQCALIQSIKDKCPCCYGPLE----CPVFPTELAFALDTSEGVNQDTFGRMRDVVL 2426
Query: 66 QVIESLDVG----PNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTG 121
++ L + P RV +V Y + V E K+ LL ++ +Q T
Sbjct: 2427 SIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQS 2486
Query: 122 L--AIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIG 179
L A+ F F R R+ + + V V P + S + R + ++L G
Sbjct: 2487 LETAMSFVARNTFK-----RVRNGFLMRKVAVFFSNTPTRA----SPQLREAVLKLSDAG 2537
Query: 180 VGSV--DKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQV 237
+ + + RQ+ + Q + ++++ R + V H C +
Sbjct: 2538 ITPLFLTRQEDRQLINALQINNT--AVGHALVLPAGRDLTDFLENVLTC-----HVCLDI 2590
Query: 238 CISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKF 297
C P + F G D+ F++D +++ F +KK+
Sbjct: 2591 CNIDPSCGFGSWRPSFRDRR---------AAGSDVDIDMAFILDSAETTTLFQFNEMKKY 2641
Query: 298 ISQIVDTLDV------SDKLAQVGLVQYSSS----------VRQEFPLGRFHTK-KDIKA 340
I+ +V LD+ S A+V +VQ++ S V+ EF L + +K K +
Sbjct: 2642 IAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDF 2701
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKK-- 398
R M+ ++ G+A++Y I+N F S P K+ ++ G + + A++
Sbjct: 2702 LSRGMTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVI 2759
Query: 399 --AKDLGFKMFAVGVGNAVE-DELREIASEP 426
AK G+ +G+G V E+ ASEP
Sbjct: 2760 LQAKCKGYFFVVLGIGRKVNIKEVYTFASEP 2790
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/178 (27%), Positives = 84/178 (47%), Gaps = 25/178 (14%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNA------TRVGMVNYAST------ 88
D+ F++DS+ + +F ++K +++ ++ LD+ P+ RV +V +A +
Sbjct: 2619 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2678
Query: 89 ----VKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT-GLAIQFAITKAFGDAEGGRSRSP 143
VK EFSL + SK L+ + R GT G AI++ I F A R
Sbjct: 2679 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR---- 2734
Query: 144 DISKVVIVVTDGRPQ---DSVQDVSARARASGVELFAIGVG-SVDKATLRQIASEPQD 197
D+ VV+++T P+ + Q V +A+ G +G+G V+ + ASEP D
Sbjct: 2735 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPND 2792
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 157 bits (396), Expect = 3e-38
Identities = 113/388 (29%), Positives = 192/388 (49%), Gaps = 36/388 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++DSS VRP F ++ F+S+++ L++GP+ RVG+V +++ V EF L+ + S
Sbjct: 829 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 888
Query: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
+A +L A+RR++ + TG A++F F + G R + + +++V G+ QD
Sbjct: 889 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIED-GVPQHLVLVLGGKSQD 947
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V + R+SG+ +G ++D+ L+ I ++P+ V V + + + + +
Sbjct: 948 DVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR--LVFTVREFRELPNIEERIMNS 1005
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
F P + T A G + D+VFL
Sbjct: 1006 F--------------------GPSAATPA-PPGVDTPPPSRP--------EKKKADIVFL 1036
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
+DGS + R ++F+ V +F+S+IVDT+ QVGLVQY+S EF L F TK+ I
Sbjct: 1037 LDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQII 1096
Query: 340 AAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
A+ + Y + T L++L N F +G+R ++ V T G+S + D +
Sbjct: 1097 DAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVS 1156
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIAS 424
G K+FAVGV N +E+ +IAS
Sbjct: 1157 LALTQRGVKVFAVGVRNIDSEEVGKIAS 1184
Score = 145 bits (366), Expect = 8e-35
Identities = 123/451 (27%), Positives = 215/451 (47%), Gaps = 50/451 (11%)
Query: 2 RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61
RV T L L +LQ L SPG+ + D+VF++D S+S P EF+ V+
Sbjct: 597 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 645
Query: 62 VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT- 120
+ ++++ LDVG + TRV ++ ++ K EF L AH SK + AV+R++P +
Sbjct: 646 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 705
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
G A+++ F G R + + +++++ G+ D V D + + GV F I
Sbjct: 706 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA- 763
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVC-I 239
+ D+ L +I+ P+ YV S S +L Q+ ++ L + EQ+ +
Sbjct: 764 RNADQEELVKISLSPE-----YVFSVSTFRELPSLEQKLLTPITTLTS------EQIQKL 812
Query: 240 SSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFIS 299
+ Y E S A D+VFLID S+ VRP+ F ++ F+S
Sbjct: 813 LASTRYPPPAVE-------------------SDAADIVFLIDSSEGVRPDGFAHIRDFVS 853
Query: 300 QIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTM-TGAAL 358
+IV L++ +VG+VQ+S+ V EF L + ++ + A+R + + TG AL
Sbjct: 854 RIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKAL 913
Query: 359 KYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVE 416
+++ N F S+G+R G + ++ G+SQD ++ A+ + G VG N
Sbjct: 914 EFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDR 973
Query: 417 DELREIASEPVAEHYFYTADFKTINQIGKKL 447
EL+ I ++P F +F+ + I +++
Sbjct: 974 TELQTITNDP--RLVFTVREFRELPNIEERI 1002
Score = 132 bits (333), Expect = 6e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F+ D S ++ +F V+ FL ++I+ L+V P TR+ + Y+ VK E H S
Sbjct: 230 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 288
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
K +L V+R++ + TG G A+ +A F + G R + +V++V GR
Sbjct: 289 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 346
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V ++ + SGV F + D A L QI P
Sbjct: 347 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 383
Query: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277
AF + ++ L GD + V + + H G G+ D+V
Sbjct: 384 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 424
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+DGS+ VR F L+K+F+ ++V++LDV +V +VQYS R EF L + K+D
Sbjct: 425 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 483
Query: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
+ AVR ++ + T TGAAL++++ N S+G+R G ++ IV T RS D + +
Sbjct: 484 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 543
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
+ K G +G+GNA E++ I+ P
Sbjct: 544 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 575
Score = 128 bits (322), Expect = 1e-29
Identities = 103/407 (25%), Positives = 175/407 (42%), Gaps = 48/407 (11%)
Query: 24 PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMV 83
P Q + + D+VF+VD S ++ F ++ F+++VI+ L++G + +V +
Sbjct: 21 PTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
Query: 84 NYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRS 142
YA TV+ EF H +K ++ AVR+++PL + TG A+ F F + G R+ +
Sbjct: 81 QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRA-A 139
Query: 143 PDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDY 202
I K+++++T G+ D + + + S + FAIG D+A L +IA +
Sbjct: 140 EGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS------ 193
Query: 203 VESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
+ P + A +G L
Sbjct: 194 -----------------------------------LVFIPAEFRAAPLQGM-LPGLLAPL 217
Query: 263 NVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSS 322
SG S D++FL DGS ++ + F +V+ F+ +I+D L+V + ++ + QYS
Sbjct: 218 RTLSGTPEESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDD 276
Query: 323 VRQEFPLGRFHTKKDIKAAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKV 379
V+ E +K +I V+ M K G AL Y F S+G+R G +
Sbjct: 277 VKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQF 336
Query: 380 GIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
++ GRS D ++ A K G F NA EL +I P
Sbjct: 337 LVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 383
Score = 99.4 bits (246), Expect = 7e-21
Identities = 58/167 (34%), Positives = 97/167 (58%), Gaps = 5/167 (2%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+VFL+DGS ++ NF ++ FI++++ L++ L QV + QY+ +VR EF T
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 335 KKDIKAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDY 391
K+++ AVR M ++ + TG+AL ++ +N FT S+G A G K+ ++ T G+S D
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
Query: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438
I+ A++ K FA+G A + EL EIA + + F A+F+
Sbjct: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 202
Score = 74.7 bits (182), Expect = 2e-13
Identities = 103/452 (22%), Positives = 182/452 (40%), Gaps = 80/452 (17%)
Query: 38 RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRA 97
+ D+VF++D S + R F++V F+S++++++ ++ +VG+V Y S EF L+
Sbjct: 1029 KKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKD 1088
Query: 98 HVSKAALLQAVRR-IQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGR 156
+K ++ A+ + + T + ++ F E G + ++ V+T G+
Sbjct: 1089 FSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF-VPEAGSRLDQRVPQIAFVITGGK 1147
Query: 157 PQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKF 216
+ QDVS GV++FA+GV ++D + +IAS V + + +LS +
Sbjct: 1148 SVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAF--RVGNVQELSELSEQV 1205
Query: 217 QEAFCVVSDLCATGDHDC--EQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSAT 274
E HD E +C PG + K CN+
Sbjct: 1206 LETL-----------HDAMHETLC---PG-----------VTDAAKACNL---------- 1230
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSS--------SVRQE 326
D++ DGS R +N + +K VD + ++++Q+ V S SV
Sbjct: 1231 DVILGFDGS---RDQNVFVAQKGFESKVDA--ILNRISQMHRVSCSGGRSPTVRVSVVAN 1285
Query: 327 FPLGRFHT------KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVG 380
P G + ++ RNM +T LK + N F SS P + KV
Sbjct: 1286 TPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYL-NKFRQSS---PDSVKVV 1341
Query: 381 IVFTDGRSQDY--INDAAKKAKDLGFK-MFAVGVGNAVEDELREIASEPVAEHYFY---- 433
I FTDG D ++ A++ + G + + VG+ V L + + Y
Sbjct: 1342 IHFTDGADGDLADLHRASENLRQEGVRALILVGLERVV--NLERLMHLEFGRGFMYDRPL 1399
Query: 434 -----TADFKTINQIGKKLQKKICVEEDPCAC 460
D++ Q+ +K C PC C
Sbjct: 1400 RLNLLDLDYELAEQLDNIAEKACC--GVPCKC 1429
Score = 70.9 bits (172), Expect = 3e-12
Identities = 98/451 (21%), Positives = 178/451 (39%), Gaps = 61/451 (13%)
Query: 6 GTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLS 65
G S+ C+L+ ++ C P C PT+L F +D+S V F +++ +
Sbjct: 1764 GDSIDQCALIQSIKDKCPCCYGPLE----CPVFPTELAFALDTSEGVNQDTFGRMRDVVL 1819
Query: 66 QVIESLDVG----PNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTG 121
++ L + P RV +V Y + V E K+ LL ++ +Q T
Sbjct: 1820 SIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQS 1879
Query: 122 L--AIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIG 179
L A+ F F R R+ + + V V P + S + R + ++L G
Sbjct: 1880 LETAMSFVARNTFK-----RVRNGFLMRKVAVFFSNTPTRA----SPQLREAVLKLSDAG 1930
Query: 180 VGSV--DKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQV 237
+ + + RQ+ + Q + ++++ R + V H C +
Sbjct: 1931 ITPLFLTRQEDRQLINALQINNT--AVGHALVLPAGRDLTDFLENVLTC-----HVCLDI 1983
Query: 238 CISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKF 297
C P + F G D+ F++D +++ F +KK+
Sbjct: 1984 CNIDPSCGFGSWRPSFRDRR---------AAGSDVDIDMAFILDSAETTTLFQFNEMKKY 2034
Query: 298 ISQIVDTLDV------SDKLAQVGLVQYSSS----------VRQEFPLGRFHTK-KDIKA 340
I+ +V LD+ S A+V +VQ++ S V+ EF L + +K K +
Sbjct: 2035 IAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDF 2094
Query: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKK-- 398
R M+ ++ G+A++Y I+N F S P K+ ++ G + + A++
Sbjct: 2095 LSRGMTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVI 2152
Query: 399 --AKDLGFKMFAVGVGNAVE-DELREIASEP 426
AK G+ +G+G V E+ ASEP
Sbjct: 2153 LQAKCKGYFFVVLGIGRKVNIKEVYTFASEP 2183
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/178 (27%), Positives = 84/178 (47%), Gaps = 25/178 (14%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNA------TRVGMVNYAST------ 88
D+ F++DS+ + +F ++K +++ ++ LD+ P+ RV +V +A +
Sbjct: 2012 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2071
Query: 89 ----VKQEFSLRAHVSKAALLQAVRRIQPLSTGTMT-GLAIQFAITKAFGDAEGGRSRSP 143
VK EFSL + SK L+ + R GT G AI++ I F A R
Sbjct: 2072 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR---- 2127
Query: 144 DISKVVIVVTDGRPQ---DSVQDVSARARASGVELFAIGVG-SVDKATLRQIASEPQD 197
D+ VV+++T P+ + Q V +A+ G +G+G V+ + ASEP D
Sbjct: 2128 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPND 2185
>gi|93141047 collagen, type XII, alpha 1 long isoform precursor
[Homo sapiens]
Length = 3063
Score = 150 bits (380), Expect = 2e-36
Identities = 74/182 (40%), Positives = 118/182 (64%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+ TDLVFL+DGS SV NF+ + FI+ +V D+ ++ +VG+VQYSS R EF L
Sbjct: 136 SAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLN 195
Query: 331 RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD 390
+++ + ++ AA++ + Y TMTG A+ YL+ N+FT S+GAR G KV I+ TDG+SQD
Sbjct: 196 QYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFPKVAIIITDGKSQD 255
Query: 391 YINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKK 450
+ A++ +++G ++F++G+ A EL++IAS P H F A+F I I ++ +
Sbjct: 256 EVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQ 315
Query: 451 IC 452
+C
Sbjct: 316 VC 317
Score = 145 bits (366), Expect = 8e-35
Identities = 72/178 (40%), Positives = 109/178 (61%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+V L+DGS S+ NF V+ FIS+IV+ D+ K Q+ L QYS R E+ L
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYIND 394
KK + AV N+ Y T+TG AL ++ +F +G RP A+K+G++ TDG+SQD +
Sbjct: 1259 KKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDVEA 1318
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC 452
+KK KD G ++FA+G+ NA E EL+ IA++P H + ADF+++++I L +C
Sbjct: 1319 PSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLC 1376
Score = 127 bits (320), Expect = 2e-29
Identities = 81/230 (35%), Positives = 114/230 (49%), Gaps = 16/230 (6%)
Query: 265 CSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVR 324
CS G A D+VFL+DGS S+ NF V+ F+ +V + ++S Q+ LVQYS
Sbjct: 431 CSRGVDIKA-DIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPH 489
Query: 325 QEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFT 384
EF L +F +DI A+ Y T TG A+ Y+ + F S G+R KV I+ T
Sbjct: 490 TEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILIT 549
Query: 385 DGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIG 444
DG+S D D A K ++ ++FAVGV +AV EL IAS P H F DF +I
Sbjct: 550 DGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRIS 609
Query: 445 KKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENT 494
+L + IC+ ++E L A+ +K K L+ E T
Sbjct: 610 FELTQSICL---------------RIEQELAAIKKKAYVPPKDLSFSEVT 644
Score = 119 bits (299), Expect = 5e-27
Identities = 67/192 (34%), Positives = 108/192 (56%), Gaps = 9/192 (4%)
Query: 40 TDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHV 99
TDLVF+VD S SV F+ + F++ ++ + D+G TRVG+V Y+S + EF+L +
Sbjct: 139 TDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYY 198
Query: 100 SKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
+ LL A+++I TMTG AI + + F ++ G R P KV I++TDG+ QD
Sbjct: 199 QRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFP---KVAIIITDGKSQD 255
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V+ + R GVE+F++G+ + D L+QIAS P HV V ++ I + +
Sbjct: 256 EVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNE---- 311
Query: 220 FCVVSDLCATGD 231
++S +C+ D
Sbjct: 312 --IISQVCSGVD 321
Score = 119 bits (298), Expect = 6e-27
Identities = 63/184 (34%), Positives = 103/184 (55%), Gaps = 4/184 (2%)
Query: 30 SRGHLCRTRP-TDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYAST 88
S G C TR D+V +VD S S+ F V+ F+S+++E D+GP ++ + Y+
Sbjct: 1187 SSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGD 1246
Query: 89 VKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKV 148
+ E+ L AH K +LLQAV + T+TG+A+ F + F G R R+ K+
Sbjct: 1247 PRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRA---RKI 1303
Query: 149 VIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSV 208
+++TDG+ QD V+ S + + GVELFAIG+ + D+ L+ IA++P D H V +
Sbjct: 1304 GVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFES 1363
Query: 209 IEKL 212
+ ++
Sbjct: 1364 LSRI 1367
Score = 119 bits (297), Expect = 8e-27
Identities = 73/191 (38%), Positives = 99/191 (51%), Gaps = 5/191 (2%)
Query: 263 NVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLD-VSDKLAQVGLVQYSS 321
+VC G + D+VFL D S S+ +NF V KFI V D +S QV VQYS
Sbjct: 2315 DVCKG----AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSD 2370
Query: 322 SVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGI 381
V+ EF L ++ K A++N+ Y T TG AL ++ + T SG R KV +
Sbjct: 2371 EVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLV 2430
Query: 382 VFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTIN 441
V TDGRSQD + AA + GF +F VGV + +EL IAS+P H F DF++
Sbjct: 2431 VVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFE 2490
Query: 442 QIGKKLQKKIC 452
+I L +C
Sbjct: 2491 KIEDNLITFVC 2501
Score = 113 bits (283), Expect = 3e-25
Identities = 58/182 (31%), Positives = 102/182 (56%), Gaps = 3/182 (1%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF+VD S S+ F KV+ FL +++S ++ PN ++ +V Y+ EF+L+
Sbjct: 440 DIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTK 499
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
+++A+ T TG A+ + K F ++G RS P KV+I++TDG+ D+
Sbjct: 500 VEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVP---KVMILITDGKSSDA 556
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAF 220
+D + + R S VE+FA+GV ++ L IAS P + HV VE + +++S + ++
Sbjct: 557 FRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSI 616
Query: 221 CV 222
C+
Sbjct: 617 CL 618
Score = 109 bits (272), Expect = 7e-24
Identities = 72/224 (32%), Positives = 108/224 (48%), Gaps = 14/224 (6%)
Query: 24 PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD-VGPNATRVGM 82
P P +R +C+ D+VF+ D+S S+ F KV F+ + D + P +V
Sbjct: 2307 PPTIPPARD-VCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSF 2365
Query: 83 VNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRS 142
V Y+ VK EF L + KA L A++ I+ T TG A+ F K G R
Sbjct: 2366 VQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNV 2425
Query: 143 PDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDY 202
P KV++VVTDGR QD V+ + + SG +F +GV VD L IAS+P + HV
Sbjct: 2426 P---KVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFI 2482
Query: 203 VESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCI---SSPG 243
V+ + EK+ +++ +C T C + + +SPG
Sbjct: 2483 VDDFESFEKIEDN------LITFVCETATSSCPLIYLDGYTSPG 2520
>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
Length = 957
Score = 150 bits (380), Expect = 2e-36
Identities = 84/205 (40%), Positives = 127/205 (61%), Gaps = 9/205 (4%)
Query: 255 LNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQV 314
L DG+ + C ++ TDLVF++DGS SV PENFE+VKK++ I D+ K QV
Sbjct: 21 LAEDGEVRSSCR----TAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQV 76
Query: 315 GLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP 374
G+VQYS E PLG + + + + AAV ++ Y+ T TG A+++ +D F SS
Sbjct: 77 GVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRF-- 134
Query: 375 GAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVED-ELREIASEPVAEHYFY 433
K+ +V TDG+SQD + DAA+ A+D +FA+GVG+ ED ELR IA++P + + FY
Sbjct: 135 -LTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFY 193
Query: 434 TADFKTINQIGKKLQKKICVEEDPC 458
D+ I++I + +++K+C EE C
Sbjct: 194 VEDYIAISKIREVMKQKLC-EESVC 217
Score = 135 bits (340), Expect = 9e-32
Identities = 89/223 (39%), Positives = 122/223 (54%), Gaps = 15/223 (6%)
Query: 11 LCSLLLLL---QALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQV 67
LC +L+LL L G S CRT PTDLVF++D S SV P FE VK +L +
Sbjct: 8 LCMVLVLLLQNSVLAEDGEVRSS----CRTAPTDLVFILDGSYSVGPENFEIVKKWLVNI 63
Query: 68 IESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFA 127
++ D+GP +VG+V Y+ E L ++ S L AV I L T TG AIQFA
Sbjct: 64 TKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFA 123
Query: 128 ITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGS-VDKA 186
+ F + S ++K+ +V+TDG+ QD V+D + AR S + LFAIGVGS + A
Sbjct: 124 LDYLFAKS------SRFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDA 177
Query: 187 TLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCAT 229
LR IA++P +V YVE Y I K+ ++ C S +C T
Sbjct: 178 ELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEES-VCPT 219
>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
Length = 1796
Score = 149 bits (376), Expect = 6e-36
Identities = 76/183 (41%), Positives = 115/183 (62%), Gaps = 2/183 (1%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+V L+DGS S+ NF LV+ F+ +V DV + ++GL QYS R E+ L F T
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYIND 394
K ++ AVRN+ Y T+TG AL Y+ +NSF +G+R G K+GI+ TDG+SQD I
Sbjct: 218 KDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIP 277
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC-- 452
++ ++ G ++FA+GV NA +EL+EIASEP + H + A+F ++ + + L + +C
Sbjct: 278 PSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLCSR 337
Query: 453 VEE 455
VEE
Sbjct: 338 VEE 340
Score = 130 bits (327), Expect = 3e-30
Identities = 70/183 (38%), Positives = 106/183 (57%), Gaps = 1/183 (0%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLD-VSDKLAQVGLVQYSSSVRQEFPL 329
++ DLVF++DGS S+ ENF + F+ V L+ + QV +VQ++ R EF L
Sbjct: 1028 AAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKL 1087
Query: 330 GRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQ 389
+ TK+ + A++++SY T TG A+KY+ D FT SG R G KV +V TDGRSQ
Sbjct: 1088 NAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRSQ 1147
Query: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQK 449
D +N +++ + G+ +FA+GV +A EL I S+P A H F+ DF +I +L
Sbjct: 1148 DDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELIT 1207
Query: 450 KIC 452
+C
Sbjct: 1208 FVC 1210
Score = 117 bits (294), Expect = 2e-26
Identities = 69/193 (35%), Positives = 108/193 (55%), Gaps = 8/193 (4%)
Query: 27 APQSRGHLCRTRP-TDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNY 85
+P+ +C+T D+V +VD S S+ F V+ FL ++ + DVG TR+G+ Y
Sbjct: 143 SPEEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQY 202
Query: 86 ASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDI 145
+ + E+ L A +K +++AVR + T+TGLA+ + +F G R+ +
Sbjct: 203 SGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRT---GV 259
Query: 146 SKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVES 205
SK+ I++TDG+ QD + S R SGVELFAIGV + D L++IASEP HV V
Sbjct: 260 SKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAE 319
Query: 206 Y----SVIEKLSR 214
+ +V+E L+R
Sbjct: 320 FDLMHTVVESLTR 332
Score = 115 bits (289), Expect = 7e-26
Identities = 69/205 (33%), Positives = 106/205 (51%), Gaps = 10/205 (4%)
Query: 34 LCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD-VGPNATRVGMVNYASTVKQE 92
+C+ DLVF+VD S S+ F K+ FL + +L+ +G + T+V MV + + E
Sbjct: 1025 VCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTE 1084
Query: 93 FSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVV 152
F L A+ +K LL A++ I T TG AI++ F AE G R I KV++V+
Sbjct: 1085 FKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLF-TAESGTRRG--IPKVIVVI 1141
Query: 153 TDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKL 212
TDGR QD V +S + G +FAIGV D + L I S+P HV +V+ + +K+
Sbjct: 1142 TDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKI 1201
Query: 213 SRKFQEAFCVVSDLCATGDHDCEQV 237
+ +++ +C T C V
Sbjct: 1202 EDE------LITFVCETASATCPVV 1220
>gi|93141049 collagen, type XII, alpha 1 short isoform precursor
[Homo sapiens]
Length = 1899
Score = 145 bits (366), Expect = 8e-35
Identities = 72/178 (40%), Positives = 109/178 (61%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+V L+DGS S+ NF V+ FIS+IV+ D+ K Q+ L QYS R E+ L
Sbjct: 35 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYIND 394
KK + AV N+ Y T+TG AL ++ +F +G RP A+K+G++ TDG+SQD +
Sbjct: 95 KKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDVEA 154
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC 452
+KK KD G ++FA+G+ NA E EL+ IA++P H + ADF+++++I L +C
Sbjct: 155 PSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLC 212
Score = 119 bits (298), Expect = 6e-27
Identities = 62/185 (33%), Positives = 104/185 (56%), Gaps = 4/185 (2%)
Query: 29 QSRGHLCRTRP-TDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYAS 87
++ G C TR D+V +VD S S+ F V+ F+S+++E D+GP ++ + Y+
Sbjct: 22 EAEGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSG 81
Query: 88 TVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISK 147
+ E+ L AH K +LLQAV + T+TG+A+ F + F G R R+ K
Sbjct: 82 DPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRA---RK 138
Query: 148 VVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYS 207
+ +++TDG+ QD V+ S + + GVELFAIG+ + D+ L+ IA++P D H V +
Sbjct: 139 IGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFE 198
Query: 208 VIEKL 212
+ ++
Sbjct: 199 SLSRI 203
Score = 119 bits (297), Expect = 8e-27
Identities = 73/191 (38%), Positives = 99/191 (51%), Gaps = 5/191 (2%)
Query: 263 NVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLD-VSDKLAQVGLVQYSS 321
+VC G + D+VFL D S S+ +NF V KFI V D +S QV VQYS
Sbjct: 1151 DVCKG----AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSD 1206
Query: 322 SVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGI 381
V+ EF L ++ K A++N+ Y T TG AL ++ + T SG R KV +
Sbjct: 1207 EVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLV 1266
Query: 382 VFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTIN 441
V TDGRSQD + AA + GF +F VGV + +EL IAS+P H F DF++
Sbjct: 1267 VVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFE 1326
Query: 442 QIGKKLQKKIC 452
+I L +C
Sbjct: 1327 KIEDNLITFVC 1337
Score = 109 bits (272), Expect = 7e-24
Identities = 72/224 (32%), Positives = 108/224 (48%), Gaps = 14/224 (6%)
Query: 24 PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD-VGPNATRVGM 82
P P +R +C+ D+VF+ D+S S+ F KV F+ + D + P +V
Sbjct: 1143 PPTIPPARD-VCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSF 1201
Query: 83 VNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRS 142
V Y+ VK EF L + KA L A++ I+ T TG A+ F K G R
Sbjct: 1202 VQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNV 1261
Query: 143 PDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDY 202
P KV++VVTDGR QD V+ + + SG +F +GV VD L IAS+P + HV
Sbjct: 1262 P---KVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFI 1318
Query: 203 VESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCI---SSPG 243
V+ + EK+ +++ +C T C + + +SPG
Sbjct: 1319 VDDFESFEKIEDN------LITFVCETATSSCPLIYLDGYTSPG 1356
>gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
sapiens]
Length = 1237
Score = 142 bits (359), Expect = 5e-34
Identities = 108/403 (26%), Positives = 191/403 (47%), Gaps = 40/403 (9%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S + V F + FL ++E L +G RVG+V ++ + FSL + +
Sbjct: 36 DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
KA +L AV+ + + G + GLA+ F + F A G R + +V+++++ G
Sbjct: 96 KAQVLGAVKALG-FAGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 153
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D ++ + + V F +G + +A L+ IA++ D V V + L K
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKLLP 211
Query: 219 AFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVF 278
V+ + + P T + D+VF
Sbjct: 212 YIVGVAQ---------RHIVLKPPTIVTQVIEV--------------------NKRDIVF 242
Query: 279 LIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDI 338
L+DGS ++ NF ++ FI++++ L++ L QV + QY+ +VR EF TK+++
Sbjct: 243 LVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREV 302
Query: 339 KAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDYINDA 395
AVR M ++ + TG+AL ++ +N FT S+G A G K+ ++ T G+S D I+
Sbjct: 303 ITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQP 362
Query: 396 AKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438
A++ K FA+G A + EL EIA + + F A+F+
Sbjct: 363 AQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 403
Score = 139 bits (351), Expect = 5e-33
Identities = 118/413 (28%), Positives = 199/413 (48%), Gaps = 43/413 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++D S VR F +K F+ +V+ESLDVG + RV +V Y+ + EF L ++++
Sbjct: 823 DVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
Query: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K ++ AVR++ L T TG A++F + + G R + + +++IV+T R D
Sbjct: 882 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI-TEGVPQLLIVLTADRSGD 940
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V++ S + G IG+G+ D ++ I+ P D+ + +L Q
Sbjct: 941 DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-----DFAVAIPTFRQLGTVQQVI 995
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
V+ L + V P G GG D+VFL
Sbjct: 996 SERVTQLTREELSRLQPVLQPLPSP----------------------GVGGKR--DVVFL 1031
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
IDGS+S PE F+ V+ I ++VD LDV +V ++Q+S + EF L +K +++
Sbjct: 1032 IDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQ 1090
Query: 340 AAVRNMSYMEKG---TMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
AV+ + KG G AL+Y+ N F G+R G + ++ + G+S D ++D
Sbjct: 1091 NAVQRL--RPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDD 1148
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
A + K G F + NA ++EL +I+ P E+ F + F+ + + +KL
Sbjct: 1149 PAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 1198
Score = 132 bits (333), Expect = 6e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F+ D S ++ +F V+ FL ++I+ L+V P TR+ + Y+ VK E H S
Sbjct: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
K +L V+R++ + TG G A+ +A F + G R + +V++V GR
Sbjct: 690 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 747
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V ++ + SGV F + D A L QI P
Sbjct: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 784
Query: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277
AF + ++ L GD + V + + H G G+ D+V
Sbjct: 785 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 825
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+DGS+ VR F L+K+F+ ++V++LDV +V +VQYS R EF L + K+D
Sbjct: 826 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 884
Query: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
+ AVR ++ + T TGAAL++++ N S+G+R G ++ IV T RS D + +
Sbjct: 885 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 944
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
+ K G +G+GNA E++ I+ P
Sbjct: 945 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
Score = 129 bits (325), Expect = 5e-30
Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S +V F V+ F+ ++ SLD+G + RVG+V ++ T EFSL + +
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K+ +L +R++Q +G TG A+ + F +A G R R + ++++++T G+ +D
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 551
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
S + +G+ F +G +KA L QIA P V ++ +S + L ++
Sbjct: 552 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 605
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
++ L E+V ++ P S D++FL
Sbjct: 606 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 635
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
DGS ++ + F +V+ F+ +I+D L+V + ++ + QYS V+ E +K +I
Sbjct: 636 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 694
Query: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
V+ M K G AL Y F S+G+R G + ++ GRS D ++ A
Sbjct: 695 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 754
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426
K G F NA EL +I P
Sbjct: 755 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+ D++FL+DGS +V NF V+ F+ +V++LD+ + +VGLVQ+S + EF L
Sbjct: 429 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 488
Query: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387
+ TK DI +R + G TG+AL Y+ N FT + G+ R ++ ++ T G+
Sbjct: 489 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
S+D AA G F VG A + EL +IA P + DF ++ + ++L
Sbjct: 549 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 606
Query: 448 QKKIC------VEEDPCA 459
+ + VEE P A
Sbjct: 607 IQPLTTYVSGGVEEVPLA 624
Score = 81.3 bits (199), Expect = 2e-15
Identities = 62/215 (28%), Positives = 108/215 (50%), Gaps = 16/215 (7%)
Query: 2 RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61
RV T L L +LQ L SPG+ + D+VF++D S+S P EF+ V+
Sbjct: 998 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 1046
Query: 62 VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-T 120
+ ++++ LDVG + TRV ++ ++ K EF L AH SK + AV+R++P +
Sbjct: 1047 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 1106
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
G A+++ F G R + + +++++ G+ D V D + + GV F I
Sbjct: 1107 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-A 1164
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRK 215
+ D+ L +I+ P E+V V ++ + L +K
Sbjct: 1165 RNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 1197
Score = 77.0 bits (188), Expect = 4e-14
Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 5/178 (2%)
Query: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRF 332
+ D++FLIDGS + NF ++ F+ +++ L + + +VG+VQ+S R F L +
Sbjct: 34 SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
Query: 333 HTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQ 389
TK + AV+ + + + G AL ++++N FT + G+R G +V ++ + G S
Sbjct: 94 STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
Query: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
D I K F +G A EL+ IA++ F +F++ + +KL
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDD--NLVFTVPEFRSFGDLQEKL 209
>gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
sapiens]
Length = 1036
Score = 139 bits (351), Expect = 5e-33
Identities = 118/413 (28%), Positives = 199/413 (48%), Gaps = 43/413 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D+VF++D S VR F +K F+ +V+ESLDVG + RV +V Y+ + EF L ++++
Sbjct: 622 DVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
Query: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K ++ AVR++ L T TG A++F + + G R + + +++IV+T R D
Sbjct: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI-TEGVPQLLIVLTADRSGD 739
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
V++ S + G IG+G+ D ++ I+ P D+ + +L Q
Sbjct: 740 DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-----DFAVAIPTFRQLGTVQQVI 794
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
V+ L + V P G GG D+VFL
Sbjct: 795 SERVTQLTREELSRLQPVLQPLPSP----------------------GVGGKR--DVVFL 830
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
IDGS+S PE F+ V+ I ++VD LDV +V ++Q+S + EF L +K +++
Sbjct: 831 IDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQ 889
Query: 340 AAVRNMSYMEKG---TMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
AV+ + KG G AL+Y+ N F G+R G + ++ + G+S D ++D
Sbjct: 890 NAVQRL--RPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDD 947
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
A + K G F + NA ++EL +I+ P E+ F + F+ + + +KL
Sbjct: 948 PAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 997
Score = 132 bits (333), Expect = 6e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F+ D S ++ +F V+ FL ++I+ L+V P TR+ + Y+ VK E H S
Sbjct: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
Query: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
K +L V+R++ + TG G A+ +A F + G R + +V++V GR
Sbjct: 489 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 546
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V ++ + SGV F + D A L QI P
Sbjct: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 583
Query: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277
AF + ++ L GD + V + + H G G+ D+V
Sbjct: 584 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 624
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+DGS+ VR F L+K+F+ ++V++LDV +V +VQYS R EF L + K+D
Sbjct: 625 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 683
Query: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394
+ AVR ++ + T TGAAL++++ N S+G+R G ++ IV T RS D + +
Sbjct: 684 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 743
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426
+ K G +G+GNA E++ I+ P
Sbjct: 744 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
Score = 129 bits (325), Expect = 5e-30
Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S +V F V+ F+ ++ SLD+G + RVG+V ++ T EFSL + +
Sbjct: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
Query: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159
K+ +L +R++Q +G TG A+ + F +A G R R + ++++++T G+ +D
Sbjct: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 350
Query: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219
S + +G+ F +G +KA L QIA P V ++ +S + L ++
Sbjct: 351 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 404
Query: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279
++ L E+V ++ P S D++FL
Sbjct: 405 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 434
Query: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339
DGS ++ + F +V+ F+ +I+D L+V + ++ + QYS V+ E +K +I
Sbjct: 435 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 493
Query: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396
V+ M K G AL Y F S+G+R G + ++ GRS D ++ A
Sbjct: 494 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 553
Query: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426
K G F NA EL +I P
Sbjct: 554 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
Score = 99.4 bits (246), Expect = 7e-21
Identities = 58/167 (34%), Positives = 97/167 (58%), Gaps = 5/167 (2%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+VFL+DGS ++ NF ++ FI++++ L++ L QV + QY+ +VR EF T
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 335 KKDIKAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDY 391
K+++ AVR M ++ + TG+AL ++ +N FT S+G A G K+ ++ T G+S D
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
Query: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438
I+ A++ K FA+G A + EL EIA + + F A+F+
Sbjct: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 202
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+ D++FL+DGS +V NF V+ F+ +V++LD+ + +VGLVQ+S + EF L
Sbjct: 228 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 287
Query: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387
+ TK DI +R + G TG+AL Y+ N FT + G+ R ++ ++ T G+
Sbjct: 288 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 347
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447
S+D AA G F VG A + EL +IA P + DF ++ + ++L
Sbjct: 348 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 405
Query: 448 QKKIC------VEEDPCA 459
+ + VEE P A
Sbjct: 406 IQPLTTYVSGGVEEVPLA 423
Score = 91.7 bits (226), Expect = 1e-18
Identities = 50/170 (29%), Positives = 91/170 (53%), Gaps = 2/170 (1%)
Query: 24 PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMV 83
P Q + + D+VF+VD S ++ F ++ F+++VI+ L++G + +V +
Sbjct: 21 PTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
Query: 84 NYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRS 142
YA TV+ EF H +K ++ AVR+++PL + TG A+ F F + G R+ +
Sbjct: 81 QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRA-A 139
Query: 143 PDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIA 192
I K+++++T G+ D + + + S + FAIG D+A L +IA
Sbjct: 140 EGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
Score = 81.3 bits (199), Expect = 2e-15
Identities = 62/215 (28%), Positives = 108/215 (50%), Gaps = 16/215 (7%)
Query: 2 RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61
RV T L L +LQ L SPG+ + D+VF++D S+S P EF+ V+
Sbjct: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 845
Query: 62 VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-T 120
+ ++++ LDVG + TRV ++ ++ K EF L AH SK + AV+R++P +
Sbjct: 846 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 905
Query: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180
G A+++ F G R + + +++++ G+ D V D + + GV F I
Sbjct: 906 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-A 963
Query: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRK 215
+ D+ L +I+ P E+V V ++ + L +K
Sbjct: 964 RNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 996
>gi|38348304 von Willebrand factor A domain containing 2 [Homo
sapiens]
Length = 725
Score = 131 bits (329), Expect = 2e-30
Identities = 113/414 (27%), Positives = 179/414 (43%), Gaps = 56/414 (13%)
Query: 11 LCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIES 70
LC L +A C+ L+ + R DL+F++DSS F + KVF+ + + +
Sbjct: 321 LCPLAFGGEANCALKLSLECR--------VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRA 372
Query: 71 LDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITK 130
+ + RVG+ Y+ + + + L+ ++ I T+TG A++ A +
Sbjct: 373 VLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAER 432
Query: 131 AFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGS-VDKATLR 189
FG A P +VV+++T+ +D V + ARA EL +GVGS +A L
Sbjct: 433 GFGSATRTGQDRP--RRVVVLLTESHSEDEVAGPARHARAR--ELLLLGVGSEAVRAELE 488
Query: 190 QIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCAC 249
+I P+ +V YS + L + E
Sbjct: 489 EITGSPK-----HVMVYSDPQDLFNQIPEL------------------------------ 513
Query: 250 HEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSD 309
GK C+ G + A DLVF++D S SV PENF ++ F+ +V+
Sbjct: 514 --------QGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
Query: 310 KLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVS 369
+ QVGLV Y S V+ F L T+ + A+ Y+ G AL ++ D TV
Sbjct: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQ 625
Query: 370 SGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIA 423
GARPG K +V T GR + A+K ++ G + VGVG + + LR +A
Sbjct: 626 RGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
Score = 130 bits (327), Expect = 3e-30
Identities = 127/491 (25%), Positives = 209/491 (42%), Gaps = 79/491 (16%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
D++F++D S SV FE+ K F V + LD+ P RVG ++ST EF L + +
Sbjct: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
+ + ++R+ T T LA+++ + + GGR+ S + +++I+VTDG+ Q
Sbjct: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGL---PGGRNAS--VPQILIIVTDGKSQGD 165
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEK--LSRKFQE 218
V S + + GV +FA+GV L +ASEP+ +HV E S
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSS 225
Query: 219 AFC-VVSDLCATGDHDCE-------------------------------------QVCIS 240
A C + C H CE +V ++
Sbjct: 226 AICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLT 285
Query: 241 SPGS---YTC-------ACHEGFTLNSDGK-----TCNVCSGGGGSSA--------TDLV 277
P + TC C G T +G C + GG + A DL+
Sbjct: 286 HPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLL 345
Query: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
FL+D S + F K F+ + V + D A+VG+ YS + P+G + D
Sbjct: 346 FLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPD 405
Query: 338 IKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPG---AQKVGIVFTDGRSQDYIND 394
+ ++ + + T+TG+AL+ + F S R G ++V ++ T+ S+D +
Sbjct: 406 LVWSLDGIPFRGGPTLTGSALRQAAERGF--GSATRTGQDRPRRVVVLLTESHSEDEVAG 463
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTI-NQIGKKLQKKICV 453
A+ A+ + VG AV EL EI P +H +D + + NQI +LQ K+C
Sbjct: 464 PARHARARELLLLGVG-SEAVRAELEEITGSP--KHVMVYSDPQDLFNQI-PELQGKLCS 519
Query: 454 EEDP-CACESL 463
+ P C ++L
Sbjct: 520 RQRPGCRTQAL 530
Score = 107 bits (268), Expect = 2e-23
Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%)
Query: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
S+A D++FL+DGS SV +FE K F + D LD+S + +VG Q+SS+ EFPL
Sbjct: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
Query: 331 RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD 390
F T++++KA ++ M + T T ALKYL+ + G ++ I+ TDG+SQ
Sbjct: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRG--LPGGRNASVPQILIIVTDGKSQG 164
Query: 391 YINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEH 430
+ +K+ K+ G +FAVGV +EL +ASEP +H
Sbjct: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQH 204
Score = 89.0 bits (219), Expect = 9e-18
Identities = 55/173 (31%), Positives = 92/173 (53%), Gaps = 5/173 (2%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFS 94
CRT+ DLVF++D+S SV P F +++ F+ +V P+ T+VG+V Y S V+ F
Sbjct: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
Query: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTD 154
L ++AA+L+A+ + L G A+ K G R P + K V+V+T
Sbjct: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR---PGVPKAVVVLTG 641
Query: 155 GRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYS 207
GR + + + R +G+ + +GVG V LR++A P+D + +V +Y+
Sbjct: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PRDSLI-HVAAYA 692
>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
Length = 1284
Score = 130 bits (328), Expect = 2e-30
Identities = 71/178 (39%), Positives = 103/178 (57%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
D+VFL+DGS S+ +F+ VK F++ ++ ++ QVGL QYS + E+ L T
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYIND 394
K+ + AAVR + Y T TG AL +++ + ++G RP A KV I+ TDG+SQD ++
Sbjct: 239 KEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHT 298
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC 452
AA+ KDLG +FAVGV NA E ELR +AS P DF + + L + IC
Sbjct: 299 AARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLIC 356
Score = 114 bits (286), Expect = 2e-25
Identities = 66/183 (36%), Positives = 103/183 (56%), Gaps = 3/183 (1%)
Query: 39 PTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAH 98
P D+VF+VD S S+ F++VK FL+ VI ++GP+ +VG+ Y+ + E+ L +
Sbjct: 177 PADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSL 236
Query: 99 VSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158
+K +L AVRR++ T TGLA+ + + A G R P+ +KVVI+VTDG+ Q
Sbjct: 237 STKEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLR---PEAAKVVILVTDGKSQ 293
Query: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218
D V + + GV +FA+GV + D+A LR +AS P+D V V + + L+
Sbjct: 294 DDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSR 353
Query: 219 AFC 221
C
Sbjct: 354 LIC 356
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 125 bits (315), Expect = 7e-29
Identities = 68/182 (37%), Positives = 107/182 (58%), Gaps = 3/182 (1%)
Query: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLD--VSDKLAQVGLVQYSSSVRQEFPLG 330
A D+VFL+DGS S+ NF V+ F+ +V S + + VQYS R EF L
Sbjct: 36 AADIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLD 95
Query: 331 RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD 390
+ D+ A+R +SY T TGAA+ ++ D+ F + ARPG KV I+ TDG+SQD
Sbjct: 96 ALGSGGDVIRAIRELSYKGGNTRTGAAILHVADHVF-LPQLARPGVPKVCILITDGKSQD 154
Query: 391 YINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKK 450
++ AA++ K G K+FAVG+ NA +EL+ +AS+P ++ +F+ DF + + + ++
Sbjct: 155 LVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRR 214
Query: 451 IC 452
+C
Sbjct: 215 VC 216
Score = 94.0 bits (232), Expect = 3e-19
Identities = 64/222 (28%), Positives = 106/222 (47%), Gaps = 14/222 (6%)
Query: 13 SLLLLLQALCS------PGLAPQSRGHLCRTR--PTDLVFVVDSSRSVRPVEFEKVKVFL 64
+L LL+ ALC+ P + Q R + TR D+VF++D S S+ F +V+ FL
Sbjct: 2 TLRLLVAALCAGILAEAPRVRAQHRERVTCTRLYAADIVFLLDGSSSIGRSNFREVRSFL 61
Query: 65 SQVIESLDVGPNA--TRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGL 122
++ +A R V Y+ + EF L A S +++A+R + T TG
Sbjct: 62 EGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGDVIRAIRELSYKGGNTRTGA 121
Query: 123 AIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGS 182
AI F + P + KV I++TDG+ QD V + R + GV+LFA+G+ +
Sbjct: 122 AILHVADHVFLP----QLARPGVPKVCILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKN 177
Query: 183 VDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVS 224
D L+++AS+P + +V +S++ L C +
Sbjct: 178 ADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRVCTTA 219
Score = 43.5 bits (101), Expect = 4e-04
Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 11/185 (5%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLD-VSDKLAQVGLVQYSSSVRQEFPLGRFH 333
D+VFL ++ E ++ + ++V L + + QVGL+ YS FPL H
Sbjct: 1054 DVVFLPHATQD-NAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPLFPLNGSH 1112
Query: 334 TKKDIKAAVRNMSYMEK-----GTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRS 388
I +R+M YM+ GT A +Y++ + G R V ++ D
Sbjct: 1113 DLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPD---APGRRQHVPGVMVLLVDEPL 1169
Query: 389 QDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIA-SEPVAEHYFYTADFKTINQIGKKL 447
+ I ++A+ G + +G+ A ++LR +A + +F D +++Q L
Sbjct: 1170 RGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQAVSGL 1229
Query: 448 QKKIC 452
+C
Sbjct: 1230 ATALC 1234
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/162 (23%), Positives = 74/162 (45%), Gaps = 7/162 (4%)
Query: 34 LCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLD-VGPNATRVGMVNYASTVKQE 92
+C D+VF+ +++ E + L +++ +L +GP A +VG+++Y+
Sbjct: 1047 VCPRGLADVVFLPHATQD-NAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPL 1105
Query: 93 FSLRAHVSKAALLQAVRRIQPLS-TGTMTGLAIQFAITKAFG-DAEGGRSRSPDISKVVI 150
F L +LQ +R + + +G G A+ A DA G R P V++
Sbjct: 1106 FPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGRRQHVPG---VMV 1162
Query: 151 VVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIA 192
++ D + + A+ASG+ + +G+ D LR++A
Sbjct: 1163 LLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLA 1204
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 111 bits (278), Expect = 1e-24
Identities = 71/207 (34%), Positives = 112/207 (54%), Gaps = 20/207 (9%)
Query: 264 VCSGGGGSSAT--DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSS 321
+C G T +LVF+ID S+SV PENF+++K F+ + D + + A++G++ YS
Sbjct: 785 ICGCGPKCKETPLELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSH 844
Query: 322 SVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGI 381
V + L +F +K D K AV NM Y+ +GT T AL+ D + ARPG +KV +
Sbjct: 845 KVEKVANLKQFSSKDDFKLAVDNMQYLGEGTYTATALQAAND----MFEDARPGVKKVAL 900
Query: 382 VFTDG----RSQDYINDAAKKAKDLGFKMFAVGV-------GNAVEDELREIASEPVAEH 430
V TDG R ++ + + K A D ++F +GV E+ IA++P EH
Sbjct: 901 VITDGQTDSRDKEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDP--EH 958
Query: 431 YFYTADFKTI-NQIGKKLQKKICVEED 456
+ DF T+ + + +KL +KIC + D
Sbjct: 959 VYQFDDFFTLQDTLKQKLFQKICEDFD 985
Score = 86.7 bits (213), Expect = 5e-17
Identities = 62/202 (30%), Positives = 103/202 (50%), Gaps = 21/202 (10%)
Query: 32 GHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQ 91
G C+ P +LVFV+DSS SV P F+ +K F+ + + + + R+G++NY+ V++
Sbjct: 789 GPKCKETPLELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEK 848
Query: 92 EFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIV 151
+L+ SK AV +Q L GT T A+Q A F DA P + KV +V
Sbjct: 849 VANLKQFSSKDDFKLAVDNMQYLGEGTYTATALQ-AANDMFEDAR------PGVKKVALV 901
Query: 152 VTDG----RPQDSVQDVSARARASGVELFAIGV-------GSVDKATLRQIASEPQDEHV 200
+TDG R ++ + +V A + VE+F IGV + + IA++P EHV
Sbjct: 902 ITDGQTDSRDKEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDP--EHV 959
Query: 201 -DYVESYSVIEKLSRKFQEAFC 221
+ + +++ + L +K + C
Sbjct: 960 YQFDDFFTLQDTLKQKLFQKIC 981
Score = 53.9 bits (128), Expect = 3e-07
Identities = 57/215 (26%), Positives = 99/215 (46%), Gaps = 23/215 (10%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVF---LSQVIESLDVGPNA---TRVGMVNYASTVKQEFS 94
D+VF+VDSS S + F+K K F LS I L G + ++ + ++S+V+ +
Sbjct: 48 DIVFIVDSSESSKIALFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLAALQFSSSVQIDPP 107
Query: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFA--ITKAFGDAEGGRSRSPDISKVVIVV 152
+ Q V+ + + GT + AI A + K G +G KVV+++
Sbjct: 108 FSSWKDLQTFKQKVKSMNLIGQGTFSYYAISNATRLLKREGRKDG--------VKVVLLM 159
Query: 153 TDG--RPQD-SVQDVSARARASGVELFAIGVGS-VDKATLRQIASEPQDEHVDYVESYSV 208
TDG P++ VQ +S AR SG+ I + + V++A LR I+ + E + ++
Sbjct: 160 TDGIDHPKNPDVQSISEDARISGISFITIALSTVVNEAKLRLISGDSSSEPTLLLSDPTL 219
Query: 209 IEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPG 243
++K+ + F C +CE+ PG
Sbjct: 220 VDKIQDRLDILF---EKKCERKICECEKGDPGDPG 251
Score = 50.4 bits (119), Expect = 4e-06
Identities = 52/205 (25%), Positives = 96/205 (46%), Gaps = 27/205 (13%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVD---------TLDVSDKLAQVGLVQYSSSVRQ 325
D+VF++D S+S + F+ K F+ + D +L+ KLA +Q+SSSV+
Sbjct: 48 DIVFIVDSSESSKIALFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLA---ALQFSSSVQI 104
Query: 326 EFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSF-TVSSGARPGAQKVGIVFT 384
+ P + + K V++M+ + +GT + Y I N+ + R KV ++ T
Sbjct: 105 DPPFSSWKDLQTFKQKVKSMNLIGQGTFS----YYAISNATRLLKREGRKDGVKVVLLMT 160
Query: 385 DG----RSQDYINDAAKKAKDLGFKMFAVGVGNAV-EDELREIASEPVAEHYFYTADFKT 439
DG ++ D + ++ A+ G + + V E +LR I+ + +E +D
Sbjct: 161 DGIDHPKNPD-VQSISEDARISGISFITIALSTVVNEAKLRLISGDSSSEPTLLLSDPTL 219
Query: 440 INQIGKKLQ---KKICVEEDPCACE 461
+++I +L +K C E C CE
Sbjct: 220 VDKIQDRLDILFEKKC-ERKICECE 243
>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
Length = 2813
Score = 110 bits (274), Expect = 4e-24
Identities = 103/442 (23%), Positives = 187/442 (42%), Gaps = 48/442 (10%)
Query: 17 LLQALCSPGLAPQSR-GHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGP 75
+ Q PGL S G + D+ FV++ S + +F + K F+ +VI+ +DVG
Sbjct: 1473 MAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQ 1532
Query: 76 NATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTG-TMTGLAIQFAITKAFGD 134
++ V ++ Y+ V E+ SK +LQ VR I+ T TGLA+++ +F
Sbjct: 1533 DSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLV 1592
Query: 135 AEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASE 194
++G R ++P++ V +VT D ++ + +++ IGVG A ++++
Sbjct: 1593 SQGDREQAPNL---VYMVTGNPASDEIKRLPG-----DIQVVPIGVGP--NANVQEL--- 1639
Query: 195 PQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFT 254
E + + + +I+ +EA +V C +G+ Q+ SP
Sbjct: 1640 ---ERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEG--LQIPTLSPAP---------- 1684
Query: 255 LNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQV 314
C S D++ L+DGS S F+ +K F + ++ +L QV
Sbjct: 1685 ------DC--------SQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQV 1730
Query: 315 GLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP 374
++QY S + P K + + V M + G AL + + + GARP
Sbjct: 1731 SVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARP 1790
Query: 375 GAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFY- 433
GA K ++ S D ++ AA A+ +F +G+G+ + I + P +
Sbjct: 1791 GASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVK 1850
Query: 434 ---TADFKTINQIGKKLQKKIC 452
D T+ +G K+C
Sbjct: 1851 LQRIEDLPTMVTLGNSFLHKLC 1872
Score = 91.7 bits (226), Expect = 1e-18
Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 36/396 (9%)
Query: 37 TRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLR 96
+R DLVF++D S + EFE +K F+ ++E L + RV +V Y L+
Sbjct: 1273 SRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLK 1332
Query: 97 AHVSKAALLQAVRRIQPL-STGTMTGLAIQFAITKAFGDAEGGRSRSPDISKV-VIVVTD 154
+ L + +++ S T +++ + + F + P+ S++ ++++
Sbjct: 1333 DRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKID-----RPEASRITLLLMAS 1387
Query: 155 GRPQDSVQDVSARARA-SGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLS 213
PQ ++ + ++ I VG A L+QI + + S +++L
Sbjct: 1388 QEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELE 1447
Query: 214 RKFQEAFCVVSDLCA-----TGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGG 268
++ E + DL T D QV + PG +++ G N
Sbjct: 1448 QQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVG-PGL--------LGVSTLGPKRN----- 1493
Query: 269 GGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFP 328
S D+ F+++GS + +F K+F+ +++ +DV V ++QYS V E+P
Sbjct: 1494 --SMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYP 1551
Query: 329 LGRFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGR 387
+K DI VR + Y T TG AL+YL D+SF VS G R A + + T
Sbjct: 1552 FSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNP 1611
Query: 388 SQDYINDAAKKAKDLGFKMFAVGVG-NAVEDELREI 422
+ D I K ++ +GVG NA EL I
Sbjct: 1612 ASDEI-----KRLPGDIQVVPIGVGPNANVQELERI 1642
Score = 73.2 bits (178), Expect = 5e-13
Identities = 61/216 (28%), Positives = 95/216 (43%), Gaps = 17/216 (7%)
Query: 16 LLLQALCS------PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIE 69
L+LQ CS P L+P C ++P D++ ++D S S F+++K F I
Sbjct: 1664 LVLQRCCSGEGLQIPTLSPAPD---C-SQPLDVILLLDGSSSFPASYFDEMKSFAKAFIS 1719
Query: 70 SLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAIT 129
++GP T+V ++ Y S + KA LL V +Q + G A+ FA+
Sbjct: 1720 KANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVR 1779
Query: 130 KAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGS-VDKATL 188
+ G R P SK V+++ DSV + AR++ V +F IG+G D A L
Sbjct: 1780 YLTSEMHGAR---PGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQL 1836
Query: 189 RQIASEPQDEHV---DYVESYSVIEKLSRKFQEAFC 221
R +A D +V +E + L F C
Sbjct: 1837 RILAGPAGDSNVVKLQRIEDLPTMVTLGNSFLHKLC 1872
>gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens]
Length = 1028
Score = 94.0 bits (232), Expect = 3e-19
Identities = 112/448 (25%), Positives = 190/448 (42%), Gaps = 76/448 (16%)
Query: 12 CSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESL 71
C +L ++ +CS C+ P DL+FV+DSS S+ FE K F+ +VI+ L
Sbjct: 594 CEILDIIMKMCSCCE--------CKCGPIDLLFVLDSSESIGLQNFEIAKDFVVKVIDRL 645
Query: 72 D------VGPNATRVGMVNYA-STVKQEFSLRAHVSK--AALLQAVRRIQPLSTGTMTGL 122
P + G+V Y+ S +++ SLR+ + L +A++ +Q ++ GT TG
Sbjct: 646 SRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGE 705
Query: 123 AIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARAS-GVELFAIGVG 181
A+Q+ + + R + +V+TDGR S G+++ ++G+
Sbjct: 706 ALQYTRDQLLPPSPNNR--------IALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIK 757
Query: 182 SV-----DKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQ 236
V L I+ + V E + ++AF + ++ A Q
Sbjct: 758 DVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENYAELLEDAF--LKNVTA-------Q 808
Query: 237 VCISSP-GSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVK 295
+CI YTC SS D+ L+DGS SV NF+ K
Sbjct: 809 ICIDKKCPDYTCPI-------------------TFSSPADITILLDGSASVGSHNFDTTK 849
Query: 296 KFISQIVDTLDVSDKL-----AQVGLVQYSSSVRQ---EFPLGRFHTKKDIKAAVRNMSY 347
+F ++ + + + +V +VQYS + +Q L + +AV M +
Sbjct: 850 RFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDAMDF 909
Query: 348 MEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD----YINDAAKKAKDLG 403
+ T AL Y+ SSGA A+K ++F+DG SQ I A ++A+ G
Sbjct: 910 INDATDVNDALGYVTRFYREASSGA---AKKRLLLFSDGNSQGATPAAIEKAVQEAQRAG 966
Query: 404 FKMFAVGVGNAV-EDELREIASEPVAEH 430
++F V VG V E +R + + AE+
Sbjct: 967 IEIFVVVVGRQVNEPHIRVLVTGKTAEY 994
Score = 48.1 bits (113), Expect = 2e-05
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 23/184 (12%)
Query: 275 DLVFLIDGSKSV----RPEN--FELVKKFISQIVDTLDVS------DKLAQVGLVQYSSS 322
DL F++D S+SV +P + VK F + +D L + + G + YS
Sbjct: 37 DLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDE 96
Query: 323 VRQEFPLGRFHTKKD-IKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGI 381
V L R +D +K++V + Y KGT T A+K ++ + G+ K I
Sbjct: 97 VEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQ--LLVGGSHLKENKYLI 154
Query: 382 VFTDGRSQD-------YINDAAKKAKDLGFKMFAVGV-GNAVEDELREIASEPVAEHYFY 433
V TDG + + DA +AK LG K+F+V + + +E L IA++ F
Sbjct: 155 VVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFT 214
Query: 434 TADF 437
AD+
Sbjct: 215 AADW 218
Score = 38.9 bits (89), Expect = 0.011
Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 25/162 (15%)
Query: 39 PTDLVFVVDSSRSV----RP--VEFEKVKVFLSQVIESL-DVGPNATR-----VGMVNYA 86
P DL FV+D+S SV +P +KVK F + I++L D R G ++Y+
Sbjct: 35 PVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYS 94
Query: 87 STVKQEFSL-RAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDI 145
V+ L R + AL +V ++ GT T AI+ + + GG
Sbjct: 95 DEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLL---VGGSHLKE-- 149
Query: 146 SKVVIVVTDGRPQD-------SVQDVSARARASGVELFAIGV 180
+K +IVVTDG P + ++D A+ GV++F++ +
Sbjct: 150 NKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAI 191
>gi|40068485 von Willebrand factor A domain containing 1 isoform 1
[Homo sapiens]
Length = 445
Score = 94.0 bits (232), Expect = 3e-19
Identities = 62/177 (35%), Positives = 89/177 (50%), Gaps = 1/177 (0%)
Query: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
DL+FL+D S SV F V++F+ Q+V L + + LV S EFP G+ +
Sbjct: 34 DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93
Query: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYIND 394
+ + AVR + T TG AL Y + F +SGARPG KV + TDG S D +
Sbjct: 94 GEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGP 153
Query: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
++ KDLG +F V G EL AS P AE + + D ++ I ++L+ I
Sbjct: 154 PMQELKDLGVTVFIVSTGRGNFLELSAAASAP-AEKHLHFVDVDDLHIIVQELRGSI 209
Score = 90.9 bits (224), Expect = 2e-18
Identities = 56/164 (34%), Positives = 83/164 (50%), Gaps = 3/164 (1%)
Query: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
DL+F++DSS SV EF +V+ F+ Q++ L +G A R +V+ S EF H S
Sbjct: 34 DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93
Query: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
A AVR T TGLA+ +A + F +A G R P + KV++ VTDG D
Sbjct: 94 GEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGAR---PGVPKVLVWVTDGGSSDP 150
Query: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVE 204
V + GV +F + G + L AS P ++H+ +V+
Sbjct: 151 VGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVD 194
>gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens]
Length = 1153
Score = 93.6 bits (231), Expect = 4e-19
Identities = 63/218 (28%), Positives = 109/218 (50%), Gaps = 19/218 (8%)
Query: 274 TDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFH 333
+D+ FLIDGS S+ P +F +K+F+S +++ L S L L+QYS R F F
Sbjct: 149 SDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTL--FSLMQYSEEFRIHFTFKEFQ 206
Query: 334 TKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRS----- 388
+ ++ V+ ++ + T T ++ ++ F +++GAR A K+ +V TDG
Sbjct: 207 NNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPL 266
Query: 389 --QDYINDAAKKAKDLGFKMFAVGVGNAV-----EDELREIASEPVAEHYFYTADFKTIN 441
+D I +A ++ G + +GVG+A EL IAS+P +H F +F+ +
Sbjct: 267 GYEDVIPEADRE----GVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALK 322
Query: 442 QIGKKLQKKI-CVEEDPCACESLVKFQAKVEGLLQALT 478
I +L++KI +E S + + EG A+T
Sbjct: 323 TIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT 360
Score = 70.5 bits (171), Expect = 3e-12
Identities = 49/192 (25%), Positives = 88/192 (45%), Gaps = 13/192 (6%)
Query: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFS 94
C +D+ F++D S S+ P +F ++K F+S V+E L + T ++ Y+ + F+
Sbjct: 144 CPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLK--KSKTLFSLMQYSEEFRIHFT 201
Query: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTD 154
+ + V+ I L T T I+ + + F G R + K+++V+TD
Sbjct: 202 FKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNA---FKILVVITD 258
Query: 155 GRPQDS---VQDVSARARASGVELFAIGVGSV-----DKATLRQIASEPQDEHVDYVESY 206
G +DV A GV + IGVG + L IAS+P +HV V ++
Sbjct: 259 GEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNF 318
Query: 207 SVIEKLSRKFQE 218
++ + + +E
Sbjct: 319 EALKTIQNQLRE 330
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,847,782
Number of Sequences: 37866
Number of extensions: 701319
Number of successful extensions: 3196
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 1907
Number of HSP's gapped (non-prelim): 1086
length of query: 496
length of database: 18,247,518
effective HSP length: 106
effective length of query: 390
effective length of database: 14,233,722
effective search space: 5551151580
effective search space used: 5551151580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.