Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4502231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502231 aryl hydrocarbon receptor nuclear translocator
isoform 1 [Homo sapiens]
(789 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 1602 0.0
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 1561 0.0
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 857 0.0
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 661 0.0
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 298 2e-80
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 144 4e-34
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 135 2e-31
gi|4758010 clock [Homo sapiens] 130 6e-30
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 127 5e-29
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 127 5e-29
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 112 1e-24
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 112 2e-24
gi|21614542 single-minded homolog 1 [Homo sapiens] 106 1e-22
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 101 3e-21
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 100 4e-21
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 100 9e-21
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 93 8e-19
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 91 5e-18
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 77 8e-14
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 77 8e-14
gi|194097341 period 1 [Homo sapiens] 75 2e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 74 4e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 74 4e-13
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 74 4e-13
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 74 4e-13
gi|12707562 period 2 [Homo sapiens] 73 9e-13
gi|8567388 period 3 [Homo sapiens] 70 6e-12
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 1602 bits (4147), Expect = 0.0
Identities = 789/789 (100%), Positives = 789/789 (100%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 360
PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 360
Query: 361 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420
TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG
Sbjct: 361 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420
Query: 421 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 480
QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ
Sbjct: 421 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 480
Query: 481 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK
Sbjct: 481 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
Query: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF
Sbjct: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
Query: 601 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 660
RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT
Sbjct: 601 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 660
Query: 661 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 720
RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA
Sbjct: 661 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 720
Query: 721 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 780
EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD
Sbjct: 721 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 780
Query: 781 LTMFPPFSE 789
LTMFPPFSE
Sbjct: 781 LTMFPPFSE 789
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 1561 bits (4043), Expect = 0.0
Identities = 773/789 (97%), Positives = 773/789 (97%), Gaps = 15/789 (1%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
RCDDDQMSND KER ARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61 RCDDDQMSND---------------KERFARENHSEIERRRRNKMTAYITELSDMVPTCS 105
Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 106 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 165
Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 166 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 225
Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 226 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 285
Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 360
PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP
Sbjct: 286 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 345
Query: 361 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420
TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG
Sbjct: 346 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 405
Query: 421 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 480
QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ
Sbjct: 406 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 465
Query: 481 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK
Sbjct: 466 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
Query: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF
Sbjct: 526 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 585
Query: 601 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 660
RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT
Sbjct: 586 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 645
Query: 661 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 720
RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA
Sbjct: 646 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 705
Query: 721 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 780
EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD
Sbjct: 706 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 765
Query: 781 LTMFPPFSE 789
LTMFPPFSE
Sbjct: 766 LTMFPPFSE 774
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 857 bits (2213), Expect = 0.0
Identities = 470/797 (58%), Positives = 570/797 (71%), Gaps = 104/797 (13%)
Query: 8 PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
PEM SD+P + P A+G ++ GA+ R KRR G+DFDD DGEG SKF
Sbjct: 10 PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63
Query: 62 CDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSA 121
+RENHSEIERRRRNKMT YITELSDMVPTCSA
Sbjct: 64 ----------------------------SRENHSEIERRRRNKMTQYITELSDMVPTCSA 95
Query: 122 LARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSC 181
LARKPDKLTILRMAVSHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+
Sbjct: 96 LARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155
Query: 182 ETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKT 241
ETGRV+YVSDSVTPVLNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKT
Sbjct: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215
Query: 242 GTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEP 301
GTVKKEGQQSSMRMCMGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE
Sbjct: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275
Query: 302 HFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPT 361
+ VVHCTGYIKAWPPAG+++P++D + GQGSK+CLVAIGRLQVTSSP C DM+ + PT
Sbjct: 276 QYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPT 335
Query: 362 EFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQ 421
EF+SRHN +GI TFVD RC++ +GYQPQ+LLGK+I+EFCHPEDQ LR+SFQQVVKLKGQ
Sbjct: 336 EFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQ 395
Query: 422 VLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQR 481
VLSVM+RFR+KN+EW+ +RTSSFTFQNPYSDEIEYIICTNTNVK
Sbjct: 396 VLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVK---------------- 439
Query: 482 PQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTG-PEHSK 540
+ QQQQ EL+ V RDGL+SY+ SQV P G E K
Sbjct: 440 --------------------QLQQQQAELE-VHQRDGLSSYDLSQVPVPNLPAGVHEAGK 478
Query: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
+EK+D +F+Q+RDPRF+E++ I+A + K +SS++ TQQ++SQG+ F P+ + F
Sbjct: 479 SVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPF-PSGHSGKAF 537
Query: 601 RNSGL-APPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAK 659
+S + P V +Q S+S GQ ++QISR N +Q A WT +R F QQ+ +Q ++K
Sbjct: 538 SSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVA---WT-GSRPPFPGQQIPSQ-SSK 592
Query: 660 TRTSQFGVGSFQT----PSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQF 715
T++S FG+G+ T PSS+S +S P T+SP AY SL NR FA E+GQ++GQF
Sbjct: 593 TQSSPFGIGTSHTYPADPSSYSPLSSPA--TSSPSGNAYSSLANRTPGFA-ESGQSSGQF 649
Query: 716 QTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQ---SNS 772
Q R +E VW QWQ Q HH S EQH QQPGQ EVFQ+ML M GD + +
Sbjct: 650 QGRPSE---VWSQWQSQ--HHGQQSGEQHSH----QQPGQTEVFQDMLPMPGDPTQGTGN 700
Query: 773 YNNEEFPDLTMFPPFSE 789
YN E+F DL MFPPFSE
Sbjct: 701 YNIEDFADLGMFPPFSE 717
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 661 bits (1705), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327
PHFVVVHCTGYIKAWPPAGVSLPDDDP
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 90 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 30 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89
Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 90 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149
Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209
Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 328
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 260
Query: 329 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 387
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 261 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 320
Query: 388 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 447
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 321 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 380
Query: 448 NPYSDEIEYIICTNTNV 464
NP++ E+EYI+ TNT V
Sbjct: 381 NPWTKEVEYIVSTNTVV 397
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 90 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 328
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
Query: 329 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 387
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
Query: 388 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 447
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
Query: 448 NPYSDEIEYIICTNTNV 464
NP++ E+EYI+ TNT V
Sbjct: 424 NPWTKEVEYIVSTNTVV 440
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 90 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 328
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
Query: 329 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 387
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
Query: 388 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 447
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
Query: 448 NPYSDEIEYIICTNTNV 464
NP++ E+EYI+ TNT V
Sbjct: 424 NPWTKEVEYIVSTNTVV 440
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 298 bits (762), Expect = 2e-80
Identities = 161/386 (41%), Positives = 238/386 (61%), Gaps = 14/386 (3%)
Query: 86 KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 145
K + RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G
Sbjct: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
Query: 146 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
N+ +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN Q+
Sbjct: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223
Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 264
G +L+D +HP DV K++EQLS+ + + +++D KTG V R+ GSRRSF
Sbjct: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283
Query: 265 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 324
CR++ SV + C S K F +HCTGY+++WPP V + +
Sbjct: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
Query: 325 DDPEAGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 383
+ S F CLVAIGRLQ P + NV +PTEFI+R + G F +VD R A
Sbjct: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV-KPTEFITRFAVNGKFVYVDQRATAI 391
Query: 384 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 443
+GY PQELLG + E+ H +D L D + V++ K ++L+ ++FR+K+ ++ +++
Sbjct: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451
Query: 444 FTFQNPYSDEIEYIICTNTNVKNSSQ 469
F+F NP++ E+EYI+ NT V S+
Sbjct: 452 FSFTNPWTKELEYIVSVNTLVLGHSE 477
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 144 bits (362), Expect = 4e-34
Identities = 147/558 (26%), Positives = 239/558 (42%), Gaps = 78/558 (13%)
Query: 85 DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HMK 140
+K+R R + ++ E++RR++ I ELS M+P RK DK T+L + H +
Sbjct: 5 EKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNE 61
Query: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
T +KPSFL+++E L+LEA DGF+ V+ + G ++YVSDS+TP+L
Sbjct: 62 VSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHL 120
Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
S+ L + + + ++ + LS+ L T + E +S S
Sbjct: 121 PSDVMDQNLLNFLPEQEHSEVYKILSSHM---------LVTDSPSPEYLKSD------SD 165
Query: 261 RSFICRMRCGSSSVDPV-SVNRLSFVRN-RCRNGLGSVKDGEPHFVVVHCTGYIKAWP-P 317
F C + GS + + + FV N R N + S C G+ P
Sbjct: 166 LEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPS----------CNGFDNTLSRP 215
Query: 318 AGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFTFV 376
V L G + C +A RL +M V +P E F SRH++E F F+
Sbjct: 216 CRVPL---------GKEVCFIATVRLATPQF--LKEMCIVDEPLEEFTSRHSLEWKFLFL 264
Query: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
DHR +GY P E+LG + ++ H +D +LL Q +++ G+ S +RF +K Q+W
Sbjct: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
Query: 437 LWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
+W++T + + ++ + E+I+CT++ V + ++ P + L+
Sbjct: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKG 383
Query: 497 GQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH---SKPLEKSDGLFAQDR 553
L PRQ ++ G GL + +HS ++ H S+P L A+
Sbjct: 384 SSLEPRQHFNTLDV----GASGL-NTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEAS 438
Query: 554 DPRFSEIYHNINADQSKGISSSTVPATQQL----FSQGNTFP-PTPRPAENFRNSGLAPP 608
P S+T+P Q+L SQ T P P P P+ L P
Sbjct: 439 TPALPR--------------SATLP--QELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQ 482
Query: 609 VTIVQPSASAGQMLAQIS 626
+ A Q AQ S
Sbjct: 483 TVLQSTPAPMAQFSAQFS 500
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 135 bits (339), Expect = 2e-31
Identities = 100/385 (25%), Positives = 183/385 (47%), Gaps = 46/385 (11%)
Query: 77 SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
+D E+ + ER +E + R RR+K T EL+ +P +++ DK +I+R+A+
Sbjct: 3 ADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAI 61
Query: 137 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 196
S +++ + + ++ + DQ++ +L L+A +GF+ +V+ + G ++++S++++
Sbjct: 62 SFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENISKF 118
Query: 197 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 256
+ Q E G +++D HP D +++RE LS + G KK
Sbjct: 119 MGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS----------GFGKKSKD------- 161
Query: 257 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 316
M + R F RM+C V NR R +V + V+HCTG +K +
Sbjct: 162 MSTERDFFMRMKCT--------------VTNRGR----TVNLKSATWKVLHCTGQVKVYN 203
Query: 317 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376
+ P + G I + P+ D+ F+SRH+++ FT+
Sbjct: 204 ----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIP--LDSKTFLSRHSMDMKFTYC 257
Query: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
D R +GY P+ELLG++ EF H D + + S Q + KGQV+S +R +K+ +
Sbjct: 258 DDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHGGY 316
Query: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461
+W+ T NP + + + I+C N
Sbjct: 317 VWLETQGTVIYNPRNLQPQCIMCVN 341
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 130 bits (326), Expect = 6e-30
Identities = 114/450 (25%), Positives = 207/450 (46%), Gaps = 61/450 (13%)
Query: 85 DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRG 144
DK++ R + ++ E++RR++ I EL M+P ARK DK T+L+ ++ ++ +
Sbjct: 30 DKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKE 86
Query: 145 TGNTSTDGS-----YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQ 199
+D S +KP+FL+++E L+LEA DGF F+ G ++YVS+SVT +L
Sbjct: 87 I-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGF-FLAIMTDGSIIYVSESVTSLLEH 144
Query: 200 PQSEWFGSTLYDQVHPDDVDKLREQLST---SENALTGRILDLKTGTVKKEGQQSSMRMC 256
S+ ++++ + + ++ + LST ++LT L K
Sbjct: 145 LPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSK---------------- 188
Query: 257 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 316
++ F C M G+ +DP + +V+ +G+ K H G+
Sbjct: 189 --NQLEFCCHMLRGT--IDPKEPSTYEYVKF-----IGNFKSLNSVSSSAH-NGF----- 233
Query: 317 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFTF 375
G P + C VA RL +M V +P E F SRH++E F F
Sbjct: 234 -EGTIQRTHRPS--YEDRVCFVATVRLATPQF--IKEMCTVEEPNEEFTSRHSLEWKFLF 288
Query: 376 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE 435
+DHR +GY P E+LG + ++ H +D + L + +++ G+ S +RF +K Q+
Sbjct: 289 LDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQY-GKGKSCYYRFLTKGQQ 347
Query: 436 WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG 495
W+W++T + + ++ E+I+CT+T V + +R +LG +LP
Sbjct: 348 WIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAE-------RRRELGIEESLPETAA 400
Query: 496 SGQLAPRQQQQQTELDMVPGRDGLASYNHS 525
+ ++ V ++ L ++HS
Sbjct: 401 D---KSQDSGSDNRINTVSLKEALERFDHS 427
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 127 bits (318), Expect = 5e-29
Identities = 98/385 (25%), Positives = 182/385 (47%), Gaps = 62/385 (16%)
Query: 85 DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
DK++++ E E R RR+K + EL+ +P ++ DK +++R+ +S+++
Sbjct: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
Query: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V +
Sbjct: 69 VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT------ 163
Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 164 -QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY--- 201
Query: 319 GVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376
+ P+ G + CLV I P+ +++ F+SRH+++ F++
Sbjct: 202 --DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYC 255
Query: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K +
Sbjct: 256 DERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGY 314
Query: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461
+W+ T + N + + + I+C N
Sbjct: 315 VWVETQATVIYNTKNSQPQCIVCVN 339
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 127 bits (318), Expect = 5e-29
Identities = 98/385 (25%), Positives = 182/385 (47%), Gaps = 62/385 (16%)
Query: 85 DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
DK++++ E E R RR+K + EL+ +P ++ DK +++R+ +S+++
Sbjct: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
Query: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V +
Sbjct: 69 VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT------ 163
Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 164 -QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY--- 201
Query: 319 GVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376
+ P+ G + CLV I P+ +++ F+SRH+++ F++
Sbjct: 202 --DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYC 255
Query: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K +
Sbjct: 256 DERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGY 314
Query: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461
+W+ T + N + + + I+C N
Sbjct: 315 VWVETQATVIYNTKNSQPQCIVCVN 339
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 112 bits (281), Expect = 1e-24
Identities = 89/383 (23%), Positives = 173/383 (45%), Gaps = 48/383 (12%)
Query: 79 DEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 138
D Q L +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+
Sbjct: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
Query: 139 MKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
++ R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 62 LRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLG 116
Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 117 LSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT----------------- 158
Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 159 -ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPP 199
Query: 319 GVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDH 378
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D
Sbjct: 200 AQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD 254
Query: 379 RCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLW 438
R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW
Sbjct: 255 RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLW 313
Query: 439 MRTSSFTFQNPYSDEIEYIICTN 461
+T + + E I+C +
Sbjct: 314 TQTQATVVSGGRGPQSESIVCVH 336
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 112 bits (279), Expect = 2e-24
Identities = 88/381 (23%), Positives = 173/381 (45%), Gaps = 48/381 (12%)
Query: 81 QSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
Q + L +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++
Sbjct: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Query: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 66 MHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLS 120
Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 121 QLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------E 161
Query: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 162 RCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQ 203
Query: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D R
Sbjct: 204 TSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRI 258
Query: 381 VATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 440
GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +
Sbjct: 259 AEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQ 317
Query: 441 TSSFTFQNPYSDEIEYIICTN 461
T + + E I+C +
Sbjct: 318 TQATVVSGGRGPQSESIVCVH 338
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 106 bits (264), Expect = 1e-22
Identities = 94/376 (25%), Positives = 164/376 (43%), Gaps = 53/376 (14%)
Query: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 146
+E R RR K + EL+ ++P SA+ + DK +I+R+ S++K G G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 147 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
S P +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
G+++Y+ +HP D D++ L+ + + + + + RSF
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162
Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDD 325
RM+C + + G G + V+HC+GY+K SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKI---RQYSL-DM 198
Query: 326 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVG 385
P G LVA+G S P F+ R +++ F+D R G
Sbjct: 199 SPFDGCYQNVGLVAVGH----SLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTG 254
Query: 386 YQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFT 445
Y+PQ+L+ K + H D LR + ++ +KGQV + +RF +K+ W+W+++ +
Sbjct: 255 YEPQDLIEKTLYHHVHGCDTFHLRCA-HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATI 313
Query: 446 FQNPYSDEIEYIICTN 461
N S I+ N
Sbjct: 314 VHNSRSSRPHCIVSVN 329
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 101 bits (251), Expect = 3e-21
Identities = 143/622 (22%), Positives = 245/622 (39%), Gaps = 99/622 (15%)
Query: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 324
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
Query: 325 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 383
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 384 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 443
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 444 FTFQNPYSD-------------EIEY----IICTNTNVKNSSQEPRPTLSNTIQRPQLGP 486
N S EIEY + + S R LS + + +L
Sbjct: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK 371
Query: 487 TANLPLEMG-SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKP-LEK 544
N ++ P QQ ++D + + + P + P +P E
Sbjct: 372 PKNTKMKTKLRTNPYPPQQYSSFQMDKLE----CGQLGNWRASPPASAAAPPELQPHSES 427
Query: 545 SDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFP-------PTPRPA 597
SD L+ FS YH + + SS P F Q P + PA
Sbjct: 428 SDLLYTPSYSLPFS--YHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPA 485
Query: 598 ENFRNSGLAPPV--TIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQ 655
A P+ + P+ + + A +RHS P++ SG +V
Sbjct: 486 SGECQWHYANPLVPSSSSPAKNPPEPPANTARHS-----LVPSY--EGGSGLLVGKVGGL 538
Query: 656 ATAKTRTSQFGVGSFQT-PSSF 676
TA +R+S G +T PS F
Sbjct: 539 RTAGSRSSHGGGWQMETEPSRF 560
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 100 bits (250), Expect = 4e-21
Identities = 92/378 (24%), Positives = 165/378 (43%), Gaps = 57/378 (15%)
Query: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 324
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
Query: 325 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 383
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 384 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 443
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 444 FTFQNPYSDEIEYIICTN 461
N S I+ N
Sbjct: 312 TVVHNSRSSRPHCIVSVN 329
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 99.8 bits (247), Expect = 9e-21
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 42/419 (10%)
Query: 80 EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
+Q + +ERL +E + R RR K EL+ ++P +A+ + DK +I+R+ +
Sbjct: 9 QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
Query: 137 SHMK------------SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADG 174
S++K +LR G NTS G+ + PS L + + HL IL++ DG
Sbjct: 69 SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128
Query: 175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTG 234
F+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP D ++ EQL G
Sbjct: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM--KLPPG 185
Query: 235 RILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLG 294
R L L GT E SS S S ++ R F+R +
Sbjct: 186 RGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 242
Query: 295 SVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDM 354
V + V+H TG ++ VSL Q +VA P ++
Sbjct: 243 GVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPPTINEV 294
Query: 355 SNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQ 414
C F++R N++ + ++R + P +++GK F H ED + +R S
Sbjct: 295 RIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLD 352
Query: 415 VVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRP 473
++ KGQ ++ +R+ KN ++W+++S+ N + + II N + N + P
Sbjct: 353 LLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTP 410
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 93.2 bits (230), Expect = 8e-19
Identities = 76/330 (23%), Positives = 149/330 (45%), Gaps = 48/330 (14%)
Query: 132 LRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSD 191
+R+ +S+++ R G + + L L+A +GF+ +++ E G + Y+S+
Sbjct: 1 MRLTISYLRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSE 55
Query: 192 SVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS 251
+V+ L Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 56 NVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT---------- 104
Query: 252 SMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGY 311
R F RM+ +S R R N + + V++C+G+
Sbjct: 105 --------ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGH 138
Query: 312 IKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEG 371
++A+ P + P P++ + CLV I + P+ + F+SRH+++
Sbjct: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDM 193
Query: 372 IFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRS 431
FT+ D R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +
Sbjct: 194 KFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLA 252
Query: 432 KNQEWLWMRTSSFTFQNPYSDEIEYIICTN 461
++ +LW +T + + E I+C +
Sbjct: 253 RSGGYLWTQTQATVVSGGRGPQSESIVCVH 282
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 90.5 bits (223), Expect = 5e-18
Identities = 109/438 (24%), Positives = 185/438 (42%), Gaps = 61/438 (13%)
Query: 80 EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
+Q + +ERL +E + R RR K EL+ ++P +A+ + DK +I+R+ +
Sbjct: 9 QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
Query: 137 SHMK------------SLRGTG---NTSTDGSY----------------------KPSFL 159
S++K +LR G NTS G PS L
Sbjct: 69 SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSAL 128
Query: 160 TDQELK-HL---ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHP 215
+ + HL IL++ DGF+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP
Sbjct: 129 AIEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187
Query: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 275
D ++ EQL GR L L GT E SS S S
Sbjct: 188 GDHVEMAEQLGM--KLPPGRGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTT 242
Query: 276 PVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKF 335
++ R F+R + V + V+H TG ++ VSL Q
Sbjct: 243 DNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGL 298
Query: 336 CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKN 395
+VA P ++ C F++R N++ + ++R + P +++GK
Sbjct: 299 VVVA----HALPPPTINEVRIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKR 352
Query: 396 IVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIE 455
F H ED + +R S ++ KGQ ++ +R+ KN ++W+++S+ N + +
Sbjct: 353 CYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEK 411
Query: 456 YIICTNTNVKNSSQEPRP 473
II N + N + P
Sbjct: 412 NIIWVNYLLSNPEYKDTP 429
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 76.6 bits (187), Expect = 8e-14
Identities = 96/427 (22%), Positives = 176/427 (41%), Gaps = 68/427 (15%)
Query: 98 ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 151
E+RRR + + YI EL++++ KPDK IL+ V ++ ++ G T ++
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 152 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 204
S + L L+L+A DGFLF+V+ G +V+VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152
Query: 205 FGSTLYDQVHPDD-VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSF 263
+++Y+ +H +D D L+ ++ N + + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNGV--------SWTNETQRQKS---------HTF 195
Query: 264 ICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLP 323
CRM + +N +R R + + C +S P
Sbjct: 196 NCRMLMKTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 324 DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 383
E G+ + C++ + R T T SN P FI+RH++ G +D + +
Sbjct: 233 RAMMEEGEDLQSCMICVARRITTGER--TFPSN---PESFITRHDLSGKVVNIDTNSLRS 287
Query: 384 VGYQP--QELLGKNIVEFCHPED-QQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 440
+P ++++ + I F D Q + Q L G + ++RF + + +
Sbjct: 288 -SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQ 346
Query: 441 TSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQL 499
T S F+NP +++ + T+ + + P P RP P A +G +
Sbjct: 347 TKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRP---PMAGCNSSVGGMSM 403
Query: 500 APRQQQQ 506
+P Q Q
Sbjct: 404 SPNQGLQ 410
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 76.6 bits (187), Expect = 8e-14
Identities = 96/427 (22%), Positives = 176/427 (41%), Gaps = 68/427 (15%)
Query: 98 ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 151
E+RRR + + YI EL++++ KPDK IL+ V ++ ++ G T ++
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 152 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 204
S + L L+L+A DGFLF+V+ G +V+VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152
Query: 205 FGSTLYDQVHPDD-VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSF 263
+++Y+ +H +D D L+ ++ N + + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNGV--------SWTNETQRQKS---------HTF 195
Query: 264 ICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLP 323
CRM + +N +R R + + C +S P
Sbjct: 196 NCRMLMKTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 324 DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 383
E G+ + C++ + R T T SN P FI+RH++ G +D + +
Sbjct: 233 RAMMEEGEDLQSCMICVARRITTGER--TFPSN---PESFITRHDLSGKVVNIDTNSLRS 287
Query: 384 VGYQP--QELLGKNIVEFCHPED-QQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 440
+P ++++ + I F D Q + Q L G + ++RF + + +
Sbjct: 288 -SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQ 346
Query: 441 TSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQL 499
T S F+NP +++ + T+ + + P P RP P A +G +
Sbjct: 347 TKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRP---PMAGCNSSVGGMSM 403
Query: 500 APRQQQQ 506
+P Q Q
Sbjct: 404 SPNQGLQ 410
>gi|194097341 period 1 [Homo sapiens]
Length = 1290
Score = 75.5 bits (184), Expect = 2e-13
Identities = 109/481 (22%), Positives = 178/481 (37%), Gaps = 86/481 (17%)
Query: 157 SFLTDQELKHLI----LEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQ 212
S T +EL+H+ L+ D F VS TGR+VY+S+ +L + + G+ +
Sbjct: 198 STYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSEL 257
Query: 213 VHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSS 272
+ P DV + S G TG G + + +S CR+R G
Sbjct: 258 LAPQDVGVFYGSTAPSRLPTWG------TGASAGSGLRDFTQ-----EKSVFCRIRGGPD 306
Query: 273 SVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQG 332
+D P + T Y+ + + D P
Sbjct: 307 ------------------------RDPGPRYQPFRLTPYVTK-----IRVSDGAP----A 333
Query: 333 SKFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQEL 391
CL+ R+ +P + F +RH +F VD R +GY PQ+L
Sbjct: 334 QPCCLLIAERIHSGYEAPRIPPDKRI-----FTTRHTPSCLFQDVDERAAPLLGYLPQDL 388
Query: 392 LGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLS-VMFRFRSKNQEWLWMRTSSFTFQNPY 450
LG ++ F HPED+ L+ +++++L GQ RF ++N E++ M TS F +P+
Sbjct: 389 LGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPW 448
Query: 451 SDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTEL 510
S ++ +++ P + P P +L ++ +L+ + + +
Sbjct: 449 SRKVAFVL------GRHKVRTAPLNEDVFTPPAPSPAPSLDTDI--QELSEQIHRLLLQP 500
Query: 511 DMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDP------RFSEIYHNI 564
P GL V VT+ GP HS P SD P F +I ++
Sbjct: 501 VHSPSPTGLCG------VGAVTSPGPLHS-PGSSSDSNGGDAEGPGPPAPVTFQQICKDV 553
Query: 565 NADQSKGISSSTVPATQQLFSQGNTFPPT-PRPAENFRNSGLAPPVTIVQPSASAGQMLA 623
+ + +G QQLF + P + PR A P P AG
Sbjct: 554 HLVKHQG---------QQLFIESRARPQSRPRLPATGTFKAKALPCQSPDPELEAGSAPV 604
Query: 624 Q 624
Q
Sbjct: 605 Q 605
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 95 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 381 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 437
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 438 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 497 G 497
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 500 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 552
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 553 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 612
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 613 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 663
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 664 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 717
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 718 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 774
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 3.0
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 484 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 541 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 591
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 592 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 651
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 652 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 701
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 95 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 381 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 437
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 438 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 497 G 497
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 500 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 552
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 553 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 612
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 613 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 663
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 664 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 717
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 718 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 774
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 3.0
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 484 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 541 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 591
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 592 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 651
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 652 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 701
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 95 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 381 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 437
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 438 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 497 G 497
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 500 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 552
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 553 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 612
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 613 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 663
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 664 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 717
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 718 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 774
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 3.0
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 484 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 541 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 591
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 592 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 651
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 652 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 701
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 74.3 bits (181), Expect = 4e-13
Identities = 89/375 (23%), Positives = 160/375 (42%), Gaps = 63/375 (16%)
Query: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 140
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
Query: 141 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 192
LR G + G P+ L +Q L IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
Query: 193 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS- 251
V+ L Q E GS+++D +HP D ++ EQL L+T T S
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLG------------LRTPTPGPPTPPSV 213
Query: 252 SMRMCMGSRRSFICRMRCGSSSVDPVSV--NRLSFVRNR---CRNGLGSVKDGEPHFVVV 306
S S + + + V P S+ R FVR + + GL G + V+
Sbjct: 214 SSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASG---YKVI 270
Query: 307 HCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISR 366
H TG ++A V+L P A L G + + R
Sbjct: 271 HVTGRLRAHALGLVALGHTLPPAPLAE---LPLHGHM-------------------IVFR 308
Query: 367 HNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM 426
++ + R + P EL+G++ +F H +D +R S ++ KGQV++
Sbjct: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQVMTGY 367
Query: 427 FRFRSKNQEWLWMRT 441
+R+ + ++W+++
Sbjct: 368 YRWLQRAGGFVWLQS 382
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 73.2 bits (178), Expect = 9e-13
Identities = 88/428 (20%), Positives = 167/428 (39%), Gaps = 68/428 (15%)
Query: 46 GLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKM 105
G D DD G+ + D + S D + E + + + + S+++ + ++
Sbjct: 55 GSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSG-CSSDQSSKVDTHK--EL 111
Query: 106 TAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRG---------TGNTSTDGSYKP 156
+ EL +P K L L+ A+ +K ++ + G+ P
Sbjct: 112 IKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVP 171
Query: 157 SFLTDQELKHL----ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQ 212
S+ T +E++ + I++ AD F VS +G+++Y+SD V + + + + + +
Sbjct: 172 SY-TVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEF 230
Query: 213 VHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSS 272
+ P DV S + L G S + CM +SF CR+ S
Sbjct: 231 LAPHDVGVFHSFTSPYKLPLWSMC----------SGADSFTQECM-EEKSFFCRVSVRKS 279
Query: 273 SVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQG 332
+ + + P+ V V D + +
Sbjct: 280 HENEIRYHPFRMT---------------PYLVKVR------------------DQQGAES 306
Query: 333 SKFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQEL 391
CL+ R+ +P + F + H +F VD R V +GY PQ+L
Sbjct: 307 QLCCLLLAERVHSGYEAPRIPPEKRI-----FTTTHTPNCLFQDVDERAVPLLGYLPQDL 361
Query: 392 LGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWMRTSSFTFQNPY 450
+ ++ HP D+ L+ +++++ GQ RFR++N E++ + TS +F NP+
Sbjct: 362 IETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPW 421
Query: 451 SDEIEYII 458
S +I +II
Sbjct: 422 SRKISFII 429
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 70.5 bits (171), Expect = 6e-12
Identities = 88/392 (22%), Positives = 159/392 (40%), Gaps = 73/392 (18%)
Query: 86 KERLARENHSEIERRRR--NKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLR 143
+ +LA +HSE + R R ++ + E+ P S KP L L A+ + S++
Sbjct: 34 QRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFP--SERRNKPSTLDALNYALRCVHSVQ 91
Query: 144 GTGN----TSTDGSYKP--SFLTDQELKHLILEAA----DGFLFIVSCETGRVVYVSDSV 193
S +G+ + S + +EL + E D F+ + S +GR+V++S+
Sbjct: 92 ANSEFFQILSQNGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHISEQA 151
Query: 194 TPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSE----NALTGRILDLKTGTVKKEGQ 249
+LN+ + S D + P D+ + ++ N T R + VK
Sbjct: 152 ALILNRKKDVLASSHFVDLLAPQDMRVFYAHTARAQLPFWNNWTQRAARYECAPVKP--- 208
Query: 250 QSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCT 309
F CR+R G + +C + + P+ + VH
Sbjct: 209 -------------FFCRIRGGEDRK-----------QEKCHSPFRII----PYLIHVH-- 238
Query: 310 GYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHN 368
PA L + CL + ++ +P + F + H
Sbjct: 239 ------HPAQPEL--------ESEPCCLTVVEKIHSGYEAPRIPVNKRI-----FTTTHT 279
Query: 369 IEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQ--VLSVM 426
+F VD + V +GY PQ+L+G +I+ + HPED+ L+ Q+V+K G
Sbjct: 280 PGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSP 339
Query: 427 FRFRSKNQEWLWMRTSSFTFQNPYSDEIEYII 458
RF ++N +++ + +S +F NP+S +I +II
Sbjct: 340 IRFCTQNGDYIILDSSWSSFVNPWSRKISFII 371
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,243,263
Number of Sequences: 37866
Number of extensions: 1648932
Number of successful extensions: 6220
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 5686
Number of HSP's gapped (non-prelim): 637
length of query: 789
length of database: 18,247,518
effective HSP length: 110
effective length of query: 679
effective length of database: 14,082,258
effective search space: 9561853182
effective search space used: 9561853182
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.