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Search of human proteins with 126012573
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126012573 low density lipoprotein-related protein 2 [Homo
sapiens]
(4655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 1.009e+04 0.0
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 2860 0.0
gi|93102379 low density lipoprotein-related protein 1B precursor... 2638 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 1065 0.0
gi|148727288 low density lipoprotein receptor-related protein 6 ... 686 0.0
gi|119709832 low density lipoprotein receptor-related protein 5 ... 680 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 521 e-147
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 521 e-147
gi|61744471 low density lipoprotein receptor-related protein 8 i... 506 e-142
gi|65301119 low density lipoprotein receptor-related protein 8 i... 506 e-142
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 487 e-136
gi|4507157 sortilin-related receptor containing LDLR class A rep... 481 e-135
gi|61744467 low density lipoprotein receptor-related protein 8 i... 403 e-111
gi|66082554 low density lipoprotein receptor-related protein 8 i... 379 e-104
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 235 9e-61
gi|134031945 SCO-spondin [Homo sapiens] 199 4e-50
gi|29244926 corin [Homo sapiens] 196 5e-49
gi|115298674 nidogen 1 precursor [Homo sapiens] 154 3e-36
gi|11415040 matriptase [Homo sapiens] 148 1e-34
gi|32698824 low density lipoprotein receptor-related protein 5-l... 144 3e-33
gi|209447022 low density lipoprotein receptor-related protein 5-... 144 3e-33
gi|167555125 low density lipoprotein receptor-related protein 3 ... 127 3e-28
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 127 3e-28
gi|144953895 nidogen 2 precursor [Homo sapiens] 126 4e-28
gi|208973262 low density lipoprotein-related protein 12 isoform ... 126 6e-28
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 126 6e-28
gi|28557796 low density lipoprotein receptor class A domain cont... 121 1e-26
gi|24430141 fibrillin 1 precursor [Homo sapiens] 119 7e-26
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 112 9e-24
gi|66346695 fibrillin 2 precursor [Homo sapiens] 109 7e-23
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 1.009e+04 bits (26189), Expect = 0.0
Identities = 4655/4655 (100%), Positives = 4655/4655 (100%)
Query: 1 MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI 60
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI
Sbjct: 1 MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI 60
Query: 61 GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC 120
GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC
Sbjct: 61 GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC 120
Query: 121 IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT 180
IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT
Sbjct: 121 IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT 180
Query: 181 EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV 240
EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV
Sbjct: 181 EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV 240
Query: 241 CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN 300
CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
Sbjct: 241 CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN 300
Query: 301 TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ 360
TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ
Sbjct: 301 TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ 360
Query: 361 KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES 420
KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES
Sbjct: 361 KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES 420
Query: 421 QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK 480
QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK
Sbjct: 421 QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK 480
Query: 481 IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER 540
IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER
Sbjct: 481 IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER 540
Query: 541 AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL 600
AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
Sbjct: 541 AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL 600
Query: 601 IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT 660
IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT
Sbjct: 601 IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT 660
Query: 661 NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR 720
NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR
Sbjct: 661 NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR 720
Query: 721 GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA 780
GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA
Sbjct: 721 GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA 780
Query: 781 NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL 840
NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL
Sbjct: 781 NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL 840
Query: 841 FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900
FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
Sbjct: 841 FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900
Query: 901 GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL 960
GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL
Sbjct: 901 GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL 960
Query: 961 KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE 1020
KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE
Sbjct: 961 KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE 1020
Query: 1021 PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI 1080
PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI
Sbjct: 1021 PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI 1080
Query: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE
Sbjct: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
Query: 1141 KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC 1200
KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
Sbjct: 1141 KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC 1200
Query: 1201 IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS 1260
IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS
Sbjct: 1201 IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS 1260
Query: 1261 DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL 1320
DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
Sbjct: 1261 DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL 1320
Query: 1321 GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL 1380
GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL
Sbjct: 1321 GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL 1380
Query: 1381 LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV 1440
LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV
Sbjct: 1381 LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV 1440
Query: 1441 ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR 1500
ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
Sbjct: 1441 ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR 1500
Query: 1501 RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD 1560
RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD
Sbjct: 1501 RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD 1560
Query: 1561 PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD 1620
PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD
Sbjct: 1561 PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD 1620
Query: 1621 YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM 1680
YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM
Sbjct: 1621 YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM 1680
Query: 1681 YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC 1740
YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC
Sbjct: 1681 YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC 1740
Query: 1741 LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE 1800
LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
Sbjct: 1741 LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE 1800
Query: 1801 IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL 1860
IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
Sbjct: 1801 IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL 1860
Query: 1861 IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH 1920
IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH
Sbjct: 1861 IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH 1920
Query: 1921 LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY 1980
LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY
Sbjct: 1921 LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY 1980
Query: 1981 EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL 2040
EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL
Sbjct: 1981 EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL 2040
Query: 2041 FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV 2100
FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
Sbjct: 2041 FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV 2100
Query: 2101 DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY 2160
DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY
Sbjct: 2101 DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY 2160
Query: 2161 FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL 2220
FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL
Sbjct: 2161 FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL 2220
Query: 2221 DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP 2280
DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP
Sbjct: 2221 DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP 2280
Query: 2281 YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE 2340
YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE
Sbjct: 2281 YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE 2340
Query: 2341 VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS 2400
VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
Sbjct: 2341 VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS 2400
Query: 2401 LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV 2460
LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV
Sbjct: 2401 LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV 2460
Query: 2461 IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY 2520
IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY
Sbjct: 2461 IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY 2520
Query: 2521 LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL 2580
LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL
Sbjct: 2521 LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL 2580
Query: 2581 TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 2640
TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI
Sbjct: 2581 TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 2640
Query: 2641 NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC 2700
NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
Sbjct: 2641 NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC 2700
Query: 2701 GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC
Sbjct: 2701 GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
Query: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR 2820
DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR
Sbjct: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR 2820
Query: 2821 TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH 2880
TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH
Sbjct: 2821 TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH 2880
Query: 2881 WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR 2940
WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR
Sbjct: 2881 WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR 2940
Query: 2941 HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC 3000
HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
Sbjct: 2941 HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC 3000
Query: 3001 GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG 3060
GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
Sbjct: 3001 GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG 3060
Query: 3061 SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS 3120
SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS
Sbjct: 3061 SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS 3120
Query: 3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP 3180
GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP
Sbjct: 3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP 3180
Query: 3181 GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR 3240
GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR
Sbjct: 3181 GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR 3240
Query: 3241 LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN 3300
LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
Sbjct: 3241 LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN 3300
Query: 3301 GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII 3360
GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII
Sbjct: 3301 GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII 3360
Query: 3361 STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI 3420
STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI
Sbjct: 3361 STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI 3420
Query: 3421 YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC 3480
YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC
Sbjct: 3421 YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC 3480
Query: 3481 LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD 3540
LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD
Sbjct: 3481 LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD 3540
Query: 3541 GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ 3600
GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
Sbjct: 3541 GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ 3600
Query: 3601 CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC 3660
CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC
Sbjct: 3601 CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC 3660
Query: 3661 GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH 3720
GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH
Sbjct: 3661 GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH 3720
Query: 3721 PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH 3780
PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH
Sbjct: 3721 PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH 3780
Query: 3781 YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA 3840
YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA
Sbjct: 3781 YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA 3840
Query: 3841 YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH 3900
YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
Sbjct: 3841 YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH 3900
Query: 3901 EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL 3960
EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL
Sbjct: 3901 EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL 3960
Query: 3961 GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH 4020
GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH
Sbjct: 3961 GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH 4020
Query: 4021 CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD 4080
CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD
Sbjct: 4021 CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD 4080
Query: 4081 EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY 4140
EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY
Sbjct: 4081 EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY 4140
Query: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 4201 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD 4260
WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD
Sbjct: 4201 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD 4260
Query: 4261 GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI 4320
GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI
Sbjct: 4261 GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI 4320
Query: 4321 FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP 4380
FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP
Sbjct: 4321 FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP 4380
Query: 4381 CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL 4440
CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL
Sbjct: 4381 CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL 4440
Query: 4441 AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI 4500
AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
Sbjct: 4441 AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI 4500
Query: 4501 DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE 4560
DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE
Sbjct: 4501 DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE 4560
Query: 4561 IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP 4620
IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP
Sbjct: 4561 IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP 4620
Query: 4621 AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV 4655
AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV
Sbjct: 4621 AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV 4655
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 2860 bits (7414), Expect = 0.0
Identities = 1648/4344 (37%), Positives = 2335/4344 (53%), Gaps = 288/4344 (6%)
Query: 221 TCGGYQFTCPSG-RCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRC 279
TC QF C CI + W CDGE DC D DE +C P E +C + C
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 280 ISIYKVCDGILDCPGREDENNTSTGKYCSMTL--CSALNCQYQCHETPYGGACFCPPGYI 337
+ + ++C+G+ DC DE G +C CS L CQ+ C T G C+C +
Sbjct: 86 VPMSRLCNGVQDCMDGSDE-----GPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
Query: 338 INHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEAS- 395
+ D +TC +FD+C ++G C Q C + G +C C EGY+L+ + CKA + +
Sbjct: 141 LQA-DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPP 199
Query: 396 -IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWT----DTVQNKVFS 450
++ +N +++L + G + + R + F Y + V W Q ++
Sbjct: 200 VLLIANSQNILATYLSGAQVSTITPTSTRQTTA-MDFSYANETVCWVHVGDSAAQTQLKC 258
Query: 451 VDINGLN---IQEVLNVSVETP--ENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLI 505
+ GL + +N+S+ E +A+DW+ Y V+ +RI + N +G VTL+
Sbjct: 259 ARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLL 318
Query: 506 TENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLD 565
L +P+GIA+DP +G +FF+D+ + PK+ER MDG NR LV +K+ +P G+TLD
Sbjct: 319 DLELYNPKGIALDPAMGKVFFTDYGQI---PKVERCDMDGQNRTKLVDSKIVFPHGITLD 375
Query: 566 MISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD------W 619
++S+ VYW D+ DYIE V Y+G R+T++ G LI H +G+++FE ++ T+
Sbjct: 376 LVSRLVYWADAYLDYIEVVDYEGKGRQTIIQG-ILIEHLYGLTVFENYLYATNSDNANAQ 434
Query: 620 TKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNN-----GGCEQVC 674
K +V++ N+F T QV + + + +YH RQP + +N+ GGC +C
Sbjct: 435 QKTSVIRVNRFNSTEYQVVTRVD-KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDIC 493
Query: 675 VLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN--FLIFSS--QVAIRGIPFTLSTQE 730
+L+ N C+C GF L +D + C ++ FL++ IRG+ +
Sbjct: 494 LLA----NSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPD 549
Query: 731 DVMVPVSG--NPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVES 788
+ M+P+ NP +DF A+ I+F+D + ++I +QKIDGT RE + + + NVE
Sbjct: 550 EHMIPIENLMNPR---ALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEG 606
Query: 789 LAFDWISKNLYWTDSH-YKSISVMRL--ADKTRRTVVQ-YLNNPRSVVVHPFAGYLFFTD 844
+A DW+ NLYWTD K+ISV RL A +TR+T+++ + +PR++VV P G++++TD
Sbjct: 607 VAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTD 666
Query: 845 W------FRPAKIMRAWSDGSHL-LPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHS 897
W R ++ RAW DGSH + V + T+ WPNGL++D A RLYWVDA++D+IE
Sbjct: 667 WEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETI 726
Query: 898 TFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGE---MTVIRSGI 954
+G DR+ + ++ H FGL G +LF+T++R G++ R+ + GG +T++RS
Sbjct: 727 LLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSER 786
Query: 955 AYILHLKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC 1013
I ++ YD Q G+N C NG CS C P R C C L ++ +TC
Sbjct: 787 PPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATPG-SRQCACAEDQVLDADGVTC 842
Query: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
+P+ PP QC F C N RC+ + CDG +DC DNSDE +TC S F
Sbjct: 843 LANPSYVPPP-QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFK 901
Query: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDND 1133
C + CIP W CD NDC + DE N T + +C Q++C + +CI +W CD D+D
Sbjct: 902 CENNRCIPNRWLCDGDNDCGNSEDESNA-TCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
Query: 1134 CGDGSDEKNCNSTETCQP-SQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQF 1192
CGD SDE + TC P +QF C N RCI++++ CD D DC D SDE GC +C+++QF
Sbjct: 961 CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF 1020
Query: 1193 KCASGDKCIGVTNRCDGVFDCSDNSDE--AGCP---TRPPGMCHSDEFQCQEDGICIPNF 1247
KC SG +CI CDG DC D SDE A C TRPPG CH+DEFQC+ DG+CIP
Sbjct: 1021 KCNSG-RCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
Query: 1248 WECDGHPDCLYGSDEHNA-CVPKTC-PSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKD 1304
W CDG DC+ SDE + V C PS F C D+ CI +AW+CD DNDC D SDE++
Sbjct: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
Query: 1305 CPTQPFRCPSWQWQCLGH-NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE 1363
C + R PS C + ++C+ +CDG DC +G+DE LC+ CS NGGC+H
Sbjct: 1140 CESLACRPPSHP--CANNTSVCLPPDKLCDGNDDCGDGSDEGELCD--QCSLNNGGCSHN 1195
Query: 1364 CVQEPF-GAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLE 1422
C P G C CPLG L D+ TC+ C CSQ C + S +CSC G++LE
Sbjct: 1196 CSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLE 1255
Query: 1423 SDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFW 1482
DG +C+ ++ +++++I + +++ LV +A+DF ++W
Sbjct: 1256 PDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSV--LVPGLRNTIALDFHLSQSALYW 1313
Query: 1483 SDATQGKTWSA--FQNG--TDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKI 1538
+D + K + NG T VV + E +A+DW+ N+YW + L+ IEV+K+
Sbjct: 1314 TDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKL 1373
Query: 1539 DGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH-PRIERASMDGSMRTVIVQDKI 1597
DG+ RT L++ ++ +PR +ALDPR + +LFW+DW PRIE ASM G+ R + ++
Sbjct: 1374 DGTLRTTLLAGDIEHPRAIALDPR--DGILFWTDWDASLPRIEAASMSGAGRRTVHRETG 1431
Query: 1598 F--WPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655
WP GLT+DY + + ++D+ D + Y+G +V+ + HP+A+TL+ V
Sbjct: 1432 SGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEV 1491
Query: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSH 1711
YWTD T + +ANKW G N +VV P + HPS+QP + NPC + CSH
Sbjct: 1492 YWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSH 1551
Query: 1712 LCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAM 1771
LCL++ SC CP L D C + + FL+ RQ I G+ L+ +
Sbjct: 1552 LCLINYN--RTVSCACPHLMKLHKDNTTCY-EFKKFLLYARQMEIRGVDLDAPYYNYIIS 1608
Query: 1772 VPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDW 1830
+ I N +++D EQ +YW + I R +GT S + + LA+DW
Sbjct: 1609 FTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPN-AHGLAVDW 1667
Query: 1831 ISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQ 1890
+SRNL+ T+ T ++ D ++ ++ G+ P G+ V P RGKLYW+D
Sbjct: 1668 VSRNLFWTSYDTNKKQINVARLDGSFKNAVVQ------GLEQPHGLVVHPLRGKLYWTDG 1721
Query: 1891 GTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1950
I+ ANMDG++ LF+G + + +D E KLYW +G I R N+DG
Sbjct: 1722 DN-------ISMANMDGSNRTLLFSGQKGPVG-LAIDFPESKLYWISSGNHTINRCNLDG 1773
Query: 1951 TDRMILV---HQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGL 2007
+ ++ QL +A+ L++ D+ E + KA G+ +VLR++ + +
Sbjct: 1774 SGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHM 1833
Query: 2008 QVYHRRNAAE--SSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFI 2065
+VY + +N CS N C Q+CLP SC C G+ L ++C SF+
Sbjct: 1834 KVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFL 1893
Query: 2066 VVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIR 2125
+ S+ IRG L+ +D S+ +VPV+G A+ +D + IYW D S S
Sbjct: 1894 LYSVHEGIRGIPLDPNDKSDALVPVSGTSL-AVGIDFHAENDTIYWVDMGLSTIS----- 1947
Query: 2126 RIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLL 2185
R K D + ++VT+GIG V GIAVDW+AGN+Y+T+ +IEV R+N ++R V++
Sbjct: 1948 RAKRDQTWREDVVTNGIGR--VEGIAVDWIAGNIYWTDQGFD--VIEVARLNGSFRYVVI 2003
Query: 2186 KVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSD 2245
+D PR I V P+ YLFW ++GQ P+IERS LD T R VLV+ I P G++VD D
Sbjct: 2004 SQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQD 2063
Query: 2246 GYVYWVDDSLDIIARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQAS 2304
G +YW D D I RI + GEN EV+ S + ++VFE+ I W DR
Sbjct: 2064 GKLYWCDARTDKIERIDLETGENREVV-LSSNNMDMFSVSVFEDFIYWSDRTHANGSIKR 2122
Query: 2305 KEPENTEPPTVIRDNIN-WLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGL 2363
+N +R I L+D+ +F++ Q N C NGGC LC G
Sbjct: 2123 GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQK------GTNVCAVANGGCQQLCL-YRGR 2175
Query: 2364 HTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHS----PPFQTINVER 2419
C CA G L DG +C +L+++ L+S+HL E + PF+ +
Sbjct: 2176 GQRACACAHGMLAEDGASCR-EYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMK 2234
Query: 2420 TVMSLDYD-------SVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIA 2472
V++L +D +RI+F+ + QI+ G T++ + +G+ +G+A
Sbjct: 2235 NVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN----DDGSRRITIVEN-VGSVEGLA 2289
Query: 2473 FDWITRRIYYSDYLNQMINSMAEDGSN------RTVIARV--PKPRAIVLDPCQGYLYWA 2524
+ +Y++ Y I D + TVI PRA VLD CQ ++W
Sbjct: 2290 YHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWT 2349
Query: 2525 DW-DTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGV 2583
+W + H I RA L G + ++ + P+GL +D+ + LY+ DA+L +IER G
Sbjct: 2350 NWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGS 2409
Query: 2584 DREVIVNAA-VHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINT 2642
R VI+ + VH FGL +YG++I+WTD + + RANK+ GS + ++ QP GI
Sbjct: 2410 HRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGI-I 2468
Query: 2643 VVKNQKQQCN-NPCEQFNGGCSHICAPGPNG-AECQCPHEGNWYLANNRKHCIVDNGERC 2700
V N C +PC NGGC +C G C C G L ++ C N
Sbjct: 2469 AVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC--RGGRILQDDLT-CRAVNSSCR 2525
Query: 2701 GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
F C+NG CI+ CD C D SDE S C C T C+NGRCV C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR 2820
+ +DCGDGSDE C C EF C + CI CN +C D SDE NC
Sbjct: 2586 NGADDCGDGSDEIPCNKTACGVG-EFRCRDGTCIGNSSRCNQFVDCED--ASDEMNCSAT 2642
Query: 2821 TCQSGYT---------KCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHT-CSSSEFQ 2870
C S + C +++C ++CDG NDCGD SDE C + F
Sbjct: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFA 2702
Query: 2871 CASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDND 2930
C SGRCIP W CD+E DC DE H + C +F+C RCI +W+CDG +D
Sbjct: 2703 CPSGRCIPMSWTCDKEDDCEHGEDET----HCNKFCSEAQFECQNHRCISKQWLCDGSDD 2758
Query: 2931 CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN--QNC 2988
CGD SDE C+ + C S F C P C+P+ W+CDGD DC DG DE+ C
Sbjct: 2759 CGDGSDEAAH--CEGKTCGPSSFSC----PGTHVCVPERWLCDGDKDCADGADESIAAGC 2812
Query: 2989 T-RRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERG-CLYQTCQQNQFTCQNGRCIS 3046
TC + EF C CIPK F CD DC D SDE C Y TC ++F C NGRC+S
Sbjct: 2813 LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLS 2872
Query: 3047 -KTFVCDEDNDCGDGSDELMHL--CHTPEPTC-PPHEFKCDNGRCIEMMKLCNHLDDCLD 3102
+ + CD +NDC D SDE C + E C +F C +GRC+ LCN DDC D
Sbjct: 2873 SRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGD 2932
Query: 3103 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFV 3162
+SDE+GC INEC +SGC +C D F C CRPG++L D RTC D+DEC+ F
Sbjct: 2933 SSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTT-FP 2991
Query: 3163 CSQKCENVIGSYICKCAPGYL-REPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSL 3221
CSQ+C N GSY C C GY R D +C+ ++ EP+LIF+NRYYLR L +DG Y+L
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051
Query: 3222 ILEGLDNVVALDFDRVEKRLYWID--TQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
+ +GL+N VALDFD E+ +YW D TQ +I RM LN +N + + L + LAVDW
Sbjct: 3052 LKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3111
Query: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
V LYW D D + VS LNG +R +L + PR L + Q GYLYW D
Sbjct: 3112 VGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLR--------EPRALVVDVQNGYLYWTD 3163
Query: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
WG + IGR+GMDG+++SVI+ TK+ WPNG+T+DY + +YWADA YIE++ L+G +R
Sbjct: 3164 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
Query: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
H V +PH FA+T+FED +YWTDW T+++ + +K G+N+ L++T HRP D+HV+H
Sbjct: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 3283
Query: 3460 YRQPIVSN-PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFL 3518
RQP V N PC NNGGCS+LCL+ PGG G C CP +F L G T C+ C+++QF+
Sbjct: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPGG-GHKCACPTNF-YLGSDGRT-CVSNCTASQFV 3340
Query: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNC 3578
C N+KCIP WWKCD + DC D SDE CP+ CR GQFQCS G CT+P +C+ +C
Sbjct: 3341 C-KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDC 3399
Query: 3579 PDGSDEDRLLCENHHCDSNEWQCAN-KRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRP 3637
D SDE C+ H C ++++C N RCIP ++C+ ++C D ED C TC P
Sbjct: 3400 QDNSDEAN--CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDG--EDERDCPEVTCAP 3455
Query: 3638 GQFRCA-NGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKW 3696
QF+C+ RCIP+ W CD DNDC D SDEP + + EF CK + RCIP
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEP----ANCTQMTCGVDEFRCKDSGRCIPAR 3511
Query: 3697 AVCNGVDDCRDNSDE--QGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
C+G DDC D SDE + C+ERTC P FRCKN+ C+P RWQCD NDCGDNSDEE+C
Sbjct: 3512 WKCDGEDDCGDGSDEPKEECDERTCEPY-QFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
Query: 3755 APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSE 3814
PR C+ESEF C N +CI RW CD +DC D SDE+DC R C + FQC SGHC+
Sbjct: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPR-CDMDQFQCKSGHCIPLR 3629
Query: 3815 LKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
+CD ADC+D SDE C T C F+C N +C P WKCDG+DDCGD SDE
Sbjct: 3630 WRCDADADCMDGSDEEACGTGV---RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN 3686
Query: 3875 LHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPC---TE 3930
C C FRC N+R C++ C+G D+CGDGTD EE C PT +
Sbjct: 3687 PEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTD--EEDCEPPTAHTTHCKDK 3744
Query: 3931 YEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN-KGKERTCAEN--IC--EQNCTQLNEG 3985
E+ C N C+ C+ DDCGD SDE C+ K +CA N IC E C + +
Sbjct: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKA 3804
Query: 3986 GFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGK 4045
+ C+C +GF T V + C DINEC +FGTC Q C NTKG + C CA F +
Sbjct: 3805 AY-CACRSGFHT-VPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFM----KTHN 3858
Query: 4046 RCAAEGSS-PLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYT 4104
C AEGS +L + D+ IR S Y Q + ++V D + VY+T
Sbjct: 3859 TCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWT 3917
Query: 4105 VRGEGS-RFGAIKRAYIPNFESGRNNLVQE--VDLKLKYVMQPDGIAVDWVGRHIYWSDV 4161
G+ + ++ A P + + L + + P GIA+DWV ++YW+D
Sbjct: 3918 NWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDS 3977
Query: 4162 KNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRN 4221
IEVA++ G RK LIS +D+P AI V+P G M+W+DWG PKIE+A M+G R
Sbjct: 3978 GRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRE 4037
Query: 4222 ILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIA---KEAMNPYSLD 4278
LV +++ WPTGL++DY +N+R+YW+D K VI +I+ +GTD V A + +P+S+D
Sbjct: 4038 TLVQDNIQWPTGLAVDY-HNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSID 4096
Query: 4279 IFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLC-KQI 4337
+FED +Y ++ V+K +KFG + V ++HQ + V N C ++
Sbjct: 4097 VFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK-QPEVTNPCDRKK 4155
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP---------CRCMHGGN 4388
C LCLL P G C CP G G+ + +P PPP +C +GG+
Sbjct: 4156 CEWLCLLSPSGPVCTCPNGKRLDNGT------CVPVPSPTPPPDAPRPGTCNLQCFNGGS 4209
Query: 4389 CYFDETDLPKCKCPSGYTGKYCEM 4412
C+ + PKC+C YTG CE+
Sbjct: 4210 CFLNARRQPKCRCQPRYTGDKCEL 4233
Score = 745 bits (1924), Expect = 0.0
Identities = 495/1474 (33%), Positives = 677/1474 (45%), Gaps = 200/1474 (13%)
Query: 2353 CSHLCFALPGLHTPKCDCAFGTLQSDGKNCAIST--ENFLIFALSNSLRSLHLDPENHSP 2410
CS C G + C + D +C T E FLIFA LR L+LD N++
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051
Query: 2411 PFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADG 2470
Q +N ++LD+D IY+T G I L+ G + + +G+ DG
Sbjct: 3052 LKQGLN---NAVALDFDYREQMIYWTDVTTQG-SMIRRMHLN-GSNVQVLHRTGLSNPDG 3106
Query: 2471 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWADWDT 2528
+A DW+ +Y+ D I +G+ RTV+ + +PRA+V+D GYLYW DW
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
Query: 2529 HAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVI 2588
H+ I R + G+ R IV++ + P+GLTLDY + +YW DA IE ++L G +R V+
Sbjct: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226
Query: 2589 VNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTV-VKN 2646
++ + H F LTL+ Y+YWTD T+ I RA+K G+ + + + L +P ++
Sbjct: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTL-HRPMDLHVFHALR 3285
Query: 2647 QKQQCNNPCEQFNGGCSHICAPGPNGA-ECQCPHEGNWYLANNRKHCIVDNGERCGASSF 2705
Q N+PC+ NGGCS++C P G +C CP N+YL ++ + C+ C AS F
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPT--NFYLGSDGRTCV----SNCTASQF 3339
Query: 2706 TCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYND 2765
C N +CI WKCD ++DCGD SDE C C P F C+ G C ++ CD ND
Sbjct: 3340 VCKNDKCIPFWWKCDTEDDCGDHSDEPPD-CPEFKCRPGQFQCSTGICTNPAFICDGDND 3398
Query: 2766 CGDGSDEAGCLFRDCNATTEFMCNN-RRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQS 2824
C D SDEA C C ++F C N RCIP F CNG DNC D DE++CP+ TC
Sbjct: 3399 CQDNSDEANCDIHVC-LPSQFKCTNTNRCIPGIFRCNGQDNCGDGE--DERDCPEVTCAP 3455
Query: 2825 GYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCIPQHWYC 2883
+C + CIPRV++CD DNDC D SDE P CT TC EF+C SGRCIP W C
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDE-PANCTQMTCGVDEFRCKDSGRCIPARWKC 3514
Query: 2884 DQETDCFDASDEPAS-CGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQ 2942
D E DC D SDEP C ERTC +F+C RC+P W CD DNDCGD SDE+
Sbjct: 3515 DGEDDCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEES--- 3569
Query: 2943 CQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGY 3002
C + CS+SEF C N R CI W CDGD DC DG DE ++CT R C ++F C
Sbjct: 3570 CTPRPCSESEFSCANGR-----CIAGRWKCDGDHDCADGSDE-KDCTPR-CDMDQFQCKS 3622
Query: 3003 GLCIPKIFRCDRHNDCGDYSDERGCL--YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG 3060
G CIP +RCD DC D SDE C +TC ++F C N C + CD ++DCGD
Sbjct: 3623 GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDN 3682
Query: 3061 SDELMHLCH----------------------------------TPEPTCPP--------- 3077
SDE C T E C P
Sbjct: 3683 SDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCK 3742
Query: 3078 --HEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINE-----CHDPSISGCDHNCTDTL 3130
EF C N RC+ CN DDC D SDE+ C I+ + SI G + C T
Sbjct: 3743 DKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTE 3802
Query: 3131 TSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKT 3190
+ YC+CR G+ + + C DI+EC CSQ C N G ++C CA +++ + T
Sbjct: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFG-TCSQLCNNTKGGHLCSCARNFMKTHN--T 3859
Query: 3191 CRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDN-----VVALDFDRVEKRLYWID 3245
C+ + L ++ +R+L G+ +S + + A+D R+YW +
Sbjct: 3860 CKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTN 3918
Query: 3246 TQRQVIERMFLNKTNKETIIN-HR--------------LPAAESLAVDWVSRKLYWLDAR 3290
I L T N HR L +A+DWV+ +YW D+
Sbjct: 3919 WHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSG 3978
Query: 3291 LDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVG 3350
D + V+ + G +R+ L +D P + + P G +YW+DWG+ I
Sbjct: 3979 RDVIEVAQMKGENRKTLISGMID--------EPHAIVVDPLRGTMYWSDWGNHPKIETAA 4030
Query: 3351 MDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDG--ALP 3408
MDGT + ++ ++WP G+ +DY N+ LYWADA L I L G D L
Sbjct: 4031 MDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLS 4090
Query: 3409 HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNP 3468
HPF+I +FED IY + V K +K+ S L D+ +YH ++QP V+NP
Sbjct: 4091 HPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNP 4150
Query: 3469 CGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSST-----------QF 3517
C C LCL+ P G C CP+ R L T C+P+ S T
Sbjct: 4151 CDRKK--CEWLCLLSPSGP--VCTCPNGKR---LDNGT-CVPVPSPTPPPDAPRPGTCNL 4202
Query: 3518 LCANNEKCI------PIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCT-SPQT 3570
C N C P KC Q + EL C + CR G G C SP
Sbjct: 4203 QCFNGGSCFLNARRQP---KCRCQPRYTGDKCELDQCWEH-CRNG------GTCAASPSG 4252
Query: 3571 LCNAHQNCPDGSDEDRLL--------CENHHCDSNEWQCANKRCIPE-----------SW 3611
+ CP G + N C N+ RC+P S
Sbjct: 4253 MPTCR--CPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSG 4310
Query: 3612 QCDTFNDCEDNSDE----------DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCG 3661
C+ F C+ +D + S C C RC G C+ DV +C
Sbjct: 4311 YCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCT 4366
Query: 3662 DHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPK 3695
D P C++ C N SC N + +P+
Sbjct: 4367 DGRVAP--SCLTCVGHCSN--GGSCTMNSKMMPE 4396
Score = 638 bits (1645), Expect = 0.0
Identities = 374/1072 (34%), Positives = 538/1072 (50%), Gaps = 96/1072 (8%)
Query: 17 VACLAPAS---GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGY 71
V CLA S +C F C + CI W+CDG DC D++DE C TC
Sbjct: 840 VTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDR 899
Query: 72 FKCQSEGQCIPNSWVCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCIPSEYRCDHV 130
FKC++ +CIPN W+CD D DC + DE CS TC +Q +C++G+CIP + CD
Sbjct: 900 FKCENN-RCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLD 958
Query: 131 RDCPDGADEN-DCQYPTC---EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHN 186
DC D +DE+ C YPTC Q TC+NG C N + +CD DC D+SDE C+ C
Sbjct: 959 DDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSST 1018
Query: 187 EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT--------CGGYQFTCP-SGRCIYQ 237
+F C +G CIP + CD DNDC D SDE N C +F C G CI
Sbjct: 1019 QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPL 1078
Query: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPR-EWSCPESGRCISIYKVCDGILDCPGRE 296
W CDG+ DC D+ DE CE H C P ++ C +S RCIS VCDG DC
Sbjct: 1079 RWRCDGDTDCMDSSDEKSCEG---VTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNS 1135
Query: 297 DE----------------NNTST--------------------GKYCSMTLCSALNCQYQ 320
DE NNTS G+ C + C +
Sbjct: 1136 DEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHN 1195
Query: 321 CHETPYGG-ACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYIL 379
C P G C CP G + D+ TC C C QKC+ C C EG++L
Sbjct: 1196 CSVAPGEGIVCSCPLGMELG-PDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVL 1254
Query: 380 E-RGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
E G+ C++ D F + IIFSN ++ D+H + +LV +A+ FH +
Sbjct: 1255 EPDGESCRSLDPF-KPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD--FHLSQSAL 1311
Query: 439 FWTDTVQNKVFSVDI--NG--LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMV 494
+WTD V++K++ + NG + + V+ + TPE LAVDW+ IY VE+ +++I++
Sbjct: 1312 YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVA 1371
Query: 495 NLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKT 554
LDG+ R TL+ ++ HPR IA+DP G LF++DW+ + P++E A M G+ R+ + +
Sbjct: 1372 KLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWD--ASLPRIEAASMSGAGRRTVHRE 1429
Query: 555 --KLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEG 612
GWP G+T+D + KR+ W+D+R D I + YDG V+ G + HPF V+L+ G
Sbjct: 1430 TGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGG 1489
Query: 613 QVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN--NGGC 670
+V++TDW + KANK+T N V + + +P+ + VYH RQP A NPC+ N G C
Sbjct: 1490 EVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPC 1549
Query: 671 EQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQE 730
+C++++ C C +L D C + FL+++ Q+ IRG+
Sbjct: 1550 SHLCLINYNRT-----VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604
Query: 731 DVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLA 790
++ + +D+DA++ +++SD+ I + I+GTG E + + + N LA
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
Query: 791 FDWISKNLYWT--DSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRP 848
DW+S+NL+WT D++ K I+V RL + VVQ L P +VVHP G L++TD
Sbjct: 1665 VDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTD---G 1721
Query: 849 AKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDG-----LD 903
I A DGS+ + + G P GLAID+ S+LYW+ + I DG +D
Sbjct: 1722 DNISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVID 1780
Query: 904 RRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSY 963
R Q+ LAI G+ L++ D + KADG V+R+ ++H+K Y
Sbjct: 1781 AMR----SQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
Query: 964 DVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEG 1015
D +IQ N + NGDCS C P R C C G L S CEG
Sbjct: 1837 DESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEG 1888
Score = 457 bits (1176), Expect = e-127
Identities = 267/755 (35%), Positives = 371/755 (49%), Gaps = 91/755 (12%)
Query: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFK-------- 73
P + C FRC G CI RC+ DC D +DE+ C+ C YF+
Sbjct: 2599 PCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC-SSYFRLGVKGVLF 2657
Query: 74 --CQSEGQCIPNSWVCDQDQDCDDGSDERQDC---SQSTCSSHQITCSNGQCIPSEYRCD 128
C+ C SWVCD DC D SDER DC + C + C +G+CIP + CD
Sbjct: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDER-DCPGVKRPRCPLNYFACPSGRCIPMSWTCD 2716
Query: 129 HVRDCPDGADENDC-QYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEI---------- 177
DC G DE C ++ + Q C N C + CD DC D SDE
Sbjct: 2717 KEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGP 2776
Query: 178 ----------------------NCTE--------ICLHN------EFSCGNGECIPRAYV 201
+C + CL+N EF C N +CIP+ +V
Sbjct: 2777 SSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFV 2836
Query: 202 CDHDNDCQDGSDEH-ACNYPTCGGYQFTCPSGRCI-YQNWVCDGEDDCKDNGDEDGCESG 259
CDHD DC DGSDE C YPTCG +F C +GRC+ + W CDGE+DC D DE
Sbjct: 2837 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE--APKN 2894
Query: 260 PH---DVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALN 316
PH HKC+ SGRC++ +C+G DC DE + S L
Sbjct: 2895 PHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLS---G 2951
Query: 317 CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEG 376
C C + G C C PG+ + +D RTC + D+C C Q+C + G + C C EG
Sbjct: 2952 CSQDCEDLKIGFKCRCRPGFRLK-DDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEG 3010
Query: 377 YILERG--QYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYH 434
Y G CKA E +IF+N L ++ G ++ +L + N VA+ F Y
Sbjct: 3011 YAPRGGDPHSCKAVTD-EEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALD--FDYR 3067
Query: 435 LQRVFWTD--TVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRID 492
Q ++WTD T + + + +NG N+Q + + P+ LAVDWV +Y + + I+
Sbjct: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127
Query: 493 MVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLV 552
+ L+G+YR L++ L PR + VD GYL+++DW S + R MDGS+R +V
Sbjct: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS---LIGRIGMDGSSRSVIV 3184
Query: 553 KTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEG 612
TK+ WP G+TLD +++R+YW D+R DYIE + DG R V+ IPH F ++LFE
Sbjct: 3185 DTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVL--SQDIPHIFALTLFED 3242
Query: 613 QVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATN-PCKDNNGGCE 671
V++TDW ++ +A+K T TN + RP + V+H+LRQP N PCK NNGGC
Sbjct: 3243 YVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCS 3302
Query: 672 QVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIA 706
+C+LS G G +C C F L +D R C++
Sbjct: 3303 NLCLLS-----PGGGHKCACPTNFYLGSDGRTCVS 3332
Score = 365 bits (937), Expect = e-100
Identities = 270/879 (30%), Positives = 414/879 (47%), Gaps = 93/879 (10%)
Query: 1227 PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHR 1286
P C +F C++ CI W CDG DC GSDE P+ CP S +
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDE----APEICPQS-----------K 68
Query: 1287 AWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESP 1346
A C +E +C LG +CV +S +C+G+ DC +G+DE P
Sbjct: 69 AQRC--------QPNEHNC--------------LGTELCVPMSRLCNGVQDCMDGSDEGP 106
Query: 1347 LCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYN 1406
C + GC H CV G C C F L D KTC+D DEC + G+CSQ C N
Sbjct: 107 HCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTN 166
Query: 1407 MRGSFRCSCDTGYMLESDGRTCKV---TASESLLLLVASQNKIIADSVT-SQVHNIYSLV 1462
GSF C C GY+L+ D R+CK +LL+A+ I+A ++ +QV I
Sbjct: 167 TDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTI--TP 224
Query: 1463 ENGSYIVAVDFDSISGRIFW----SDATQGKTWSAFQNG-----TDRRVVFDSSIILTET 1513
+ A+DF + + W A Q + A G + + S+ E
Sbjct: 225 TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQ 284
Query: 1514 IAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDW 1573
+AIDW+ N Y+ D + I V +G L+ L NP+G+ALDP M + +F++D+
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGK--VFFTDY 342
Query: 1574 GHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRR 1633
G P++ER MDG RT +V KI +P G+T+D +RL+Y+ D+YLDY++ DY G R
Sbjct: 343 GQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG-KGR 401
Query: 1634 QVIASDLIIRHPYALTLFEDSVYWT--DRATRR----VMRANKWHGGNQSVVMYNIQWPL 1687
Q I ++I H Y LT+FE+ +Y T D A + V+R N+++ VV +
Sbjct: 402 QTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-RVDKGG 460
Query: 1688 GIVAVHPSKQPN-SVNPCAFSR------CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC 1740
+ H +QP + C + CS +CLL++ +C C SG+SL D +C
Sbjct: 461 ALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLAN-SHKARTCRCRSGFSLGSDGKSC 519
Query: 1741 LRDDQPFLITV---RQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVEN 1797
+ + + R II G+ + +V ++ M+PI + N ++F +IY+ +
Sbjct: 520 KKPEHELFLVYGKGRPGIIRGMDMGAKV-PDEHMIPIENLMNPRALDFHAETGFIYFADT 578
Query: 1798 PGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNP-RTQSIEVLTLHGDIR 1855
I R K DGT R + +A+DW+ NLY T+ ++I V L +
Sbjct: 579 TSYLIGRQKIDGTERETILKDGIHNVE-GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQ 637
Query: 1856 YRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTD--SGVPAKIASANMDGTSVKTL 1913
RKTLI T P I VDP G +YW+D D ++ A MDG S + +
Sbjct: 638 TRKTLIEGKMT-----HPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDG-SHRDI 691
Query: 1914 FTGNLEHL--ECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH--QLSHPWGIAVH 1969
F + L ++LDI +LYW IE ++GTDR I+ +L+H +G+ H
Sbjct: 692 FVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHH 751
Query: 1970 DSFLYYTDEQYEVIERVDKATGA---NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNM 2026
++L++T+ + + R+++ G +LR P + +++Y + +N C N
Sbjct: 752 GNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNN 811
Query: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFI 2065
C +CL PG CACA L+ D +C S++
Sbjct: 812 GGCSSLCLATPGSR-QCACAEDQVLDADGVTCLANPSYV 849
Score = 246 bits (628), Expect = 4e-64
Identities = 139/373 (37%), Positives = 180/373 (48%), Gaps = 46/373 (12%)
Query: 28 CDSAHFRC-GSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
C + F+C + CIP +RC+G +C D DE C VTC F+C +CIP WV
Sbjct: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWV 3472
Query: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITC-SNGQCIPSEYRCDHVRDCPDGADE--NDCQ 143
CD+D DC DGSDE +C+Q TC + C +G+CIP+ ++CD DC DG+DE +C
Sbjct: 3473 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 3532
Query: 144 YPTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-EICLHNEFSCGNGECIPRAY 200
TCE Q C N C +CD+ DC D+SDE +CT C +EFSC NG CI +
Sbjct: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
Query: 201 VCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
CD D+DC DGSDE C P C QF C SG CI W CD + DC D DE+ C +G
Sbjct: 3593 KCDGDHDCADGSDEKDCT-PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTG- 3650
Query: 261 HDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQ 320
V C E+ C + C + CDG DC DEN ++
Sbjct: 3651 --VRTCPLDEFQC-NNTLCKPLAWKCDGEDDCGDNSDENPEECARF-------------- 3693
Query: 321 CHETPYGGACFCPPGYIINHNDSRTCVEF-------DDCQIWGICDQKCESRPGRHLCHC 373
CPP + R C+ D+C G ++ CE P H HC
Sbjct: 3694 ----------VCPPNRPFRCKNDRVCLWIGRQCDGTDNCGD-GTDEEDCEP-PTAHTTHC 3741
Query: 374 -EEGYILERGQYC 385
++ L R Q C
Sbjct: 3742 KDKKEFLCRNQRC 3754
Score = 194 bits (494), Expect = 1e-48
Identities = 115/339 (33%), Positives = 157/339 (46%), Gaps = 40/339 (11%)
Query: 33 FRCGSGHCIPADWRCDGTKDCSDDADE--IGCAVVTCQQGYFKCQSEGQCIPNSWVCDQD 90
F C +G CI CDG C D +DE C C++ + +C S G+C+ N C+
Sbjct: 2530 FECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC-SNGRCVSNMLWCNGA 2588
Query: 91 QDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQL 150
DC DGSDE C+++ C + C +G CI + RC+ DC D +DE +C C
Sbjct: 2589 DDCGDGSDE-IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSY 2647
Query: 151 -----------TCD-NGACYNTSQKCDWKVDCRDSSDEINCTEI----CLHNEFSCGNGE 194
C+ CY S CD DC D SDE +C + C N F+C +G
Sbjct: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR 2707
Query: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDED 254
CIP ++ CD ++DC+ G DE CN C QF C + RCI + W+CDG DDC D DE
Sbjct: 2708 CIPMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2766
Query: 255 G-CESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
CE C P +SCP + C+ +CDG DC DE+ + Y S
Sbjct: 2767 AHCEG-----KTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDR 2821
Query: 314 ALNCQ-YQCHETPYGGACFCPPGYIINHNDSRTCVEFDD 351
CQ QC P ++ +H+ R C + D
Sbjct: 2822 EFMCQNRQC----------IPKHFVCDHD--RDCADGSD 2848
Score = 185 bits (469), Expect = 1e-45
Identities = 105/260 (40%), Positives = 131/260 (50%), Gaps = 13/260 (5%)
Query: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPS 123
V C F C+++ +CIP W CD + DC D SDE DC + C Q CS G C
Sbjct: 3331 VSNCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNP 3389
Query: 124 EYRCDHVRDCPDGADENDCQYPTC--EQLTCDN-GACYNTSQKCDWKVDCRDSSDEINCT 180
+ CD DC D +DE +C C Q C N C +C+ + +C D DE +C
Sbjct: 3390 AFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCP 3449
Query: 181 EI-CLHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHA-CNYPTCGGYQFTC-PSGRCIY 236
E+ C N+F C CIPR +VCD DNDC DGSDE A C TCG +F C SGRCI
Sbjct: 3450 EVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIP 3509
Query: 237 QNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE 296
W CDGEDDC D DE E D C P ++ C ++ RC+ CD DC
Sbjct: 3510 ARWKCDGEDDCGDGSDEPKEEC---DERTCEPYQFRC-KNNRCVPGRWQCDYDNDCGDNS 3565
Query: 297 DENNTSTGKYCSMTLCSALN 316
DE + T + CS + S N
Sbjct: 3566 DE-ESCTPRPCSESEFSCAN 3584
Score = 171 bits (434), Expect = 1e-41
Identities = 121/388 (31%), Positives = 158/388 (40%), Gaps = 72/388 (18%)
Query: 68 QQGYFKCQ-SEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEY- 125
Q G KC+ + G C + C D+ D TC ++ QC P E+
Sbjct: 801 QVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFA 860
Query: 126 -----------RCDHVRDCPDGADEND--CQYPTC--EQLTCDNGACYNTSQKCDWKVDC 170
+CD DC D +DE C TC ++ C+N C CD DC
Sbjct: 861 CANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDC 920
Query: 171 RDSSDEINCT---EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA-CNYPTCGGY- 225
+S DE N T C N+FSC +G CIP ++ CD D+DC D SDE A C YPTC
Sbjct: 921 GNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLT 980
Query: 226 QFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKV 285
QFTC +GRCI NW CD ++DC DN DE GC H CS ++ C SGRCI +
Sbjct: 981 QFTCNNGRCININWRCDNDNDCGDNSDEAGCS------HSCSSTQFKC-NSGRCIPEHWT 1033
Query: 286 CDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQC------------------------ 321
CDG DC DE + + + ++QC
Sbjct: 1034 CDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSD 1093
Query: 322 HETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICD-----------QKCES---RPG 367
++ G C P DS C+ + W +CD + CES RP
Sbjct: 1094 EKSCEGVTHVCDPSVKFGCKDSARCIS----KAW-VCDGDNDCEDNSDEENCESLACRPP 1148
Query: 368 RHLCHCEEGYILERGQYCKANDSFGEAS 395
H C L + C ND G+ S
Sbjct: 1149 SHPCANNTSVCLPPDKLCDGNDDCGDGS 1176
Score = 169 bits (427), Expect = 8e-41
Identities = 99/270 (36%), Positives = 130/270 (48%), Gaps = 28/270 (10%)
Query: 58 DEIGCAVV--TCQ-QGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQSTCSSHQI 113
D++ C V +C+ Q F+C + G+CI S CD C D SDE+ C+ C
Sbjct: 2513 DDLTCRAVNSSCRAQDEFEC-ANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFR 2571
Query: 114 TCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCR 171
CSNG+C+ + C+ DC DG+DE C C + C +G C S +C+ VDC
Sbjct: 2572 QCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCE 2631
Query: 172 DSSDEINCTEICLHNEFSCG-----------NGECIPRAYVCDHDNDCQDGSDEHAC--- 217
D+SDE+NC+ + F G C ++VCD NDC D SDE C
Sbjct: 2632 DASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGV 2691
Query: 218 NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESG 277
P C F CPSGRCI +W CD EDDC+ DE C CS ++ C ++
Sbjct: 2692 KRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNK------FCSEAQFEC-QNH 2744
Query: 278 RCISIYKVCDGILDCPGREDENNTSTGKYC 307
RCIS +CDG DC DE GK C
Sbjct: 2745 RCISKQWLCDGSDDCGDGSDEAAHCEGKTC 2774
Score = 138 bits (347), Expect = 1e-31
Identities = 88/247 (35%), Positives = 113/247 (45%), Gaps = 38/247 (15%)
Query: 21 APASGQECDSAHFRCGSGH-CIPADWRCDGTKDCSDDADE---IGCAV-VTCQQGYFKCQ 75
A G+ C + F C H C+P W CDG KDC+D ADE GC TC F CQ
Sbjct: 2767 AHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQ 2826
Query: 76 SEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPS-EYRCDHVRDCP 134
+ QCIP +VCD D+DC DGSDE +C TC + C+NG+C+ S ++ CD DC
Sbjct: 2827 NR-QCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCH 2885
Query: 135 DGADENDCQYPTC----------EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC-TEIC 183
D +DE + P C Q C +G C + C+ + DC DSSDE C C
Sbjct: 2886 DQSDEAP-KNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINEC 2944
Query: 184 LHNEFS-CGNG----------ECIPRAYVCDHDNDCQDGSDEHACNYP-------TCGGY 225
L + S C C P + D C D DE + +P T G Y
Sbjct: 2945 LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD-VDECSTTFPCSQRCINTHGSY 3003
Query: 226 QFTCPSG 232
+ C G
Sbjct: 3004 KCLCVEG 3010
Score = 104 bits (259), Expect = 2e-21
Identities = 61/180 (33%), Positives = 84/180 (46%), Gaps = 21/180 (11%)
Query: 153 DNGACYNT-------SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHD 205
+NG C N KC + SD C C ++F C N +CIP + CD +
Sbjct: 3297 NNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTE 3356
Query: 206 NDCQDGSDEHA-CNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVH 264
+DC D SDE C C QF C +G C ++CDG++DC+DN DE C D+H
Sbjct: 3357 DDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC-----DIH 3411
Query: 265 KCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHET 324
C P ++ C + RCI C+G +C EDE + C C+ Q+QC T
Sbjct: 3412 VCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERD------CPEVTCAP--NQFQCSIT 3463
Score = 100 bits (250), Expect = 3e-20
Identities = 72/254 (28%), Positives = 99/254 (38%), Gaps = 69/254 (27%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA--VVTCQQGYFKCQSEGQCIPNSW 85
CD F+C SGHCIP WRCD DC D +DE C V TC F+C + C P +W
Sbjct: 3613 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNT-LCKPLAW 3671
Query: 86 VCDQDQDCDDGSDER-QDCSQSTCSSH--------------------------------- 111
CD + DC D SDE ++C++ C +
Sbjct: 3672 KCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731
Query: 112 --------------QITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGAC 157
+ C N +C+ S RC+ DC DG+DE DC +LT +C
Sbjct: 3732 EPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSID--PKLT----SC 3785
Query: 158 YNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNG-ECIPRAYVCDHDNDC-QDGSDEH 215
+ C DE C +C +G +P C N+C + G+
Sbjct: 3786 ATNASIC---------GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQ 3836
Query: 216 ACNYPTCGGYQFTC 229
CN T GG+ +C
Sbjct: 3837 LCN-NTKGGHLCSC 3849
Score = 78.6 bits (192), Expect = 1e-13
Identities = 46/109 (42%), Positives = 57/109 (52%), Gaps = 10/109 (9%)
Query: 3631 ASRTCRPGQFRCANG-RCIPQAWKCDVDNDCGDHSDEPIEEC-MSSAHLCDNFTEFSCKT 3688
A +TC P QF C + CI + W+CD + DC D SDE E C S A C E +C
Sbjct: 23 APKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQP-NEHNCLG 81
Query: 3689 NYRCIPKWAVCNGVDDCRDNSDE-QGCEE--RTCHPVGDFRCKNHHCIP 3734
C+P +CNGV DC D SDE C E C +G C+ HHC+P
Sbjct: 82 TELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLG---CQ-HHCVP 126
Score = 73.2 bits (178), Expect = 6e-12
Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 26/139 (18%)
Query: 1144 NSTETCQPSQFNCPNH-RCIDLSFVCDGDKDCVDGSDEVGCVL------NCTASQFKCAS 1196
++ +TC P QF C + CI + CDG++DC DGSDE + C ++ C
Sbjct: 22 DAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLG 81
Query: 1197 GDKCIGVTNRCDGVFDCSDNSDEA-------------GC-----PTRPPGMCH-SDEFQC 1237
+ C+ ++ C+GV DC D SDE GC PT C+ + FQ
Sbjct: 82 TELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQL 141
Query: 1238 QEDGICIPNFWECDGHPDC 1256
Q DG +F EC + C
Sbjct: 142 QADGKTCKDFDECSVYGTC 160
Score = 72.8 bits (177), Expect = 8e-12
Identities = 54/170 (31%), Positives = 77/170 (45%), Gaps = 39/170 (22%)
Query: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQS---TCSSHQITCSNGQ-C 120
TC F C+ + CI W CD ++DC DGSDE + C QS C ++ C + C
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 121 IPSEYRCDHVRDCPDGADENDCQYPTCEQL---------------TCDNGACYNTSQ--- 162
+P C+ V+DC DG+DE P C +L T D CY S
Sbjct: 86 VPMSRLCNGVQDCMDGSDEG----PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQL 141
Query: 163 KCDWKVDCRDSSDEIN----CTEICLHNE--FSCGNGECIPRAYVCDHDN 206
+ D K C+D DE + C+++C + + F CG C+ Y+ DN
Sbjct: 142 QADGKT-CKD-FDECSVYGTCSQLCTNTDGSFICG---CV-EGYLLQPDN 185
Score = 64.7 bits (156), Expect = 2e-09
Identities = 44/149 (29%), Positives = 60/149 (40%), Gaps = 13/149 (8%)
Query: 2820 RTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYC---TTHTCSSSEFQC-ASGR 2875
+TC C + CI + + CDG+ DC D SDE P C C +E C +
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
Query: 2876 CIPQHWYCDQETDCFDASDEPASCGHSERTC--LADEFKC----DGGRC-IPSEWICDGD 2928
C+P C+ DC D SDE C + C L + C DG C S + D
Sbjct: 85 CVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQAD 144
Query: 2929 NDCGDMSDEDKRHQCQNQNC--SDSEFLC 2955
DE + +Q C +D F+C
Sbjct: 145 GKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
Score = 56.2 bits (134), Expect = 7e-07
Identities = 49/193 (25%), Positives = 64/193 (33%), Gaps = 49/193 (25%)
Query: 156 ACYNTSQKCDWKVDCRDSSDEINCTEICL-----HNEFSCGNGECIPRAYVCDHDNDCQD 210
A N + C+ CR ++ C ++CL H SC G + C N
Sbjct: 2469 AVANDTNSCELS-PCRINNG--GCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCR 2525
Query: 211 GSDEHACNYPTCGGYQFT-----------------------------CPSGRCIYQNWVC 241
DE C C + T C +GRC+ C
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
Query: 242 DGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNT 301
+G DDC D DE C C E+ C G CI C+ +DC DE N
Sbjct: 2586 NGADDCGDGSDEIPCNK-----TACGVGEFRC-RDGTCIGNSSRCNQFVDCEDASDEMN- 2638
Query: 302 STGKYCSMTLCSA 314
CS T CS+
Sbjct: 2639 -----CSATDCSS 2646
Score = 47.4 bits (111), Expect = 3e-04
Identities = 48/204 (23%), Positives = 84/204 (41%), Gaps = 45/204 (22%)
Query: 4332 NLCKQICSHLCLL--RPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNC 4389
N C + C++ + G +C C G + S C C +GG+C
Sbjct: 4342 NKCSRCLEGACVVNKQSGDVTCNCTDGR--VAPSCLTCVG------------HCSNGGSC 4387
Query: 4390 YFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYR 4449
+ +P+C+CP TG CE PG A ++L+ +LL++++ +A F++ R
Sbjct: 4388 TMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIA-SILIPLLLLLLLVLVAGVVFWYKR 4446
Query: 4450 RTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIG------VSGFGPETAIDRS 4503
R V+ ++ +GA +N++IG G P+ D
Sbjct: 4447 R-----------------VQGAKGFQHQRMTNGA-MNVEIGNPTYKMYEGGEPD---DVG 4485
Query: 4504 MAMSEDFVMEMGKQPIIFENPMYS 4527
+ DF ++ K P F NP+Y+
Sbjct: 4486 GLLDADFALDPDK-PTNFTNPVYA 4508
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 2638 bits (6838), Expect = 0.0
Identities = 1573/4377 (35%), Positives = 2289/4377 (52%), Gaps = 344/4377 (7%)
Query: 222 CGGYQFTCPSG-RCIYQNWVCDGEDDCKDNGDEDGCESGPHDVH-KCSPREWSCPESGRC 279
C +F C C+ Q+W+CDG+ DC D+ DE ++ P +V KC +C + +C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES-LDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 280 ISIYKVCDGILDCPGREDENNTSTGKYCSMTL--CSALNCQYQCHETPYGGACFCPPGYI 337
+ + ++C+G+LDCP DE G +C L C LNCQY+C C+C G+
Sbjct: 91 VHLSQLCNGVLDCPDGYDE-----GVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFE 145
Query: 338 INHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEAS- 395
I D R+C + D+C ++G C Q C + G + C C EGY+++ + CKA +
Sbjct: 146 ITE-DGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
Query: 396 -IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQ--NKVFSVD 452
++ +N + + ++G L S N + F Y+ + W ++ + N++ +
Sbjct: 205 ILLIANFETIEVFYLNGSKMATL-SSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQ 263
Query: 453 IN---GLNIQEVLNV--SVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITE 507
I GL + +N+ S + +A+DW+ +Y V+ +RI + N +GS VTLI
Sbjct: 264 ITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDL 323
Query: 508 NLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMI 567
L +P+ IAVDP G LFF+D+ +++ K+ER MDG NR ++ +K PA + LD++
Sbjct: 324 ELHNPKAIAVDPIAGKLFFTDYGNVA---KVERCDMDGMNRTRIIDSKTEQPAALALDLV 380
Query: 568 SKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKA 627
+K VYWVD DY+ V Y G R TV+ G + H +G+++FE ++ T+ +++
Sbjct: 381 NKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRI 439
Query: 628 NKFTETNPQVYYQASLRPYGVTVYHSLRQPYA-TNPCKDNN----GGCEQVCVLSHRTDN 682
N+F T+ + +G+ +Y QP ++ C+ + GGC +C+LS
Sbjct: 440 NRFNGTDIHSLIKIE-NAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKT 498
Query: 683 DGLGFRCKCTFGFQLDTDERHCIAVQN--FLIFSS--QVAIRGIPFTLSTQEDVMVPVSG 738
C+C GF L +D R C +N FL + +RG+ ++ M+P+
Sbjct: 499 R----TCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIEN 554
Query: 739 --NPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISK 796
NP +DF A+ + I+F+D + +I +QKIDGT RE + + ++NVE +A DWI
Sbjct: 555 LVNPR---ALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGN 611
Query: 797 NLYWT-DSHYKSISVMRL--ADKTRRTVVQ-YLNNPRSVVVHPFAGYLFFTDWFRP---- 848
NLYWT D H K+I+V RL A ++R+T+++ +++PR +VV P G++++TDW
Sbjct: 612 NLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDD 671
Query: 849 --AKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRR 906
+I +AW DG + + + + WPNGL +D+ + LYW DAY+D IE +G R+
Sbjct: 672 SVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKI 731
Query: 907 LGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVN 966
+ ++ HPFGL+ G ++F+TD+ G+I ++ E+T++R + L+ YD
Sbjct: 732 VYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS-EVTLLRHERPPLFGLQIYDPR 790
Query: 967 IQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQC 1026
Q G N C NG CS C +P RVC C L N TC +P P C
Sbjct: 791 KQQGDNMCRVN---NGGCSTLCLAIPG-GRVCACADNQLLDENGTTCTFNPGEALP-HIC 845
Query: 1027 GLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRC 1086
F CKN C+ + CDG DDC D SDE N++C F C + CIP W C
Sbjct: 846 KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLC 905
Query: 1087 DKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNST 1146
D NDC DE N T +C Q++C N +CI + W+CD ++DCGD +DE
Sbjct: 906 DGANDCGSNEDESN-QTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEF 964
Query: 1147 ETCQP-SQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTN 1205
TC+P +QF C + RCI + CD D DC DGSDEVGCV +C +QF+C+SG +CI
Sbjct: 965 PTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSG-RCIPGHW 1023
Query: 1206 RCDGVFDCSDNSDEA--GCPTRP---PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS 1260
CDG DC D SDEA C P C+ +EFQC DG C+P+ W CDG DC GS
Sbjct: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
Query: 1261 DEH--NACVPKTCPSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
DE N + + F C G CI++AW+CD D DC D SDE DC + F C +
Sbjct: 1084 DEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS--FLCGPPKH 1141
Query: 1318 QCLGH-NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPF-GAKCLC 1375
C ++C+ +C+G DCP+G+DE LC+ CS NGGC++ C P G C C
Sbjct: 1142 PCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCD--ECSLNNGGCSNHCSVVPGRGIVCSC 1199
Query: 1376 PLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASES 1435
P G L D+KTCE +D C CSQ C + + +CSC G+ L+ DG +C
Sbjct: 1200 PEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFE 1259
Query: 1436 LLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTW---- 1491
++ + +++I + + +++ LV +A+DF ++W+D + + +
Sbjct: 1260 AFIIFSIRHEIRRIDLHKRDYSL--LVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKL 1317
Query: 1492 SAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNL 1551
S + VV + + E + +DW+ N+YW D L+ IEV+K+DGS RT LI+ +
Sbjct: 1318 SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAM 1377
Query: 1552 TNPRGLALDPRMNEHLLFWSDW-GHHPRIERASMDGSMRTVIVQDKIF--WPCGLTIDYP 1608
+PR +ALDPR +LFW+DW + PRIE ASM G+ R I +D WP GLT+D+
Sbjct: 1378 EHPRAIALDPRYG--ILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHF 1435
Query: 1609 NRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRA 1668
+ + + D+ D + Y+G + ++I + HP+A++L+ VYWTD T + +A
Sbjct: 1436 EKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKA 1495
Query: 1669 NKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCLLSSQGPHFYS 1724
NKW G N SV+ P + HPS+QP + NPCA + CSH+CL++ +
Sbjct: 1496 NKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHN--RSAA 1553
Query: 1725 CVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVE 1784
C CP LS D C + + FL+ R+ I G+ ++ + + I + ++
Sbjct: 1554 CACPHLMKLSSDKKTCY-EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVID 1612
Query: 1785 FDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY--STNPR 1841
FD +E+ +YW + + I R +GT S + LA+DW+SRNLY S+
Sbjct: 1613 FDASEERLYWTDIKTQTIKRAFINGTGLETVISRD-IQSIRGLAVDWVSRNLYWISSEFD 1671
Query: 1842 TQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIA 1901
I V L G + KT I + G+ P + P RGKLYW+D T I
Sbjct: 1672 ETQINVARLDGSL---KTSIIH-----GIDKPQCLAAHPVRGKLYWTDGNT-------IN 1716
Query: 1902 SANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV---H 1958
ANMDG++ K LF E + +++D E KLYW +G G I R N+DG + ++
Sbjct: 1717 MANMDGSNSKILFQNQKEPVG-LSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKE 1775
Query: 1959 QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAES 2018
+L+ + + D L++ D+ + K G N +LR+ + ++VY + A +
Sbjct: 1776 ELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKE-AQQG 1834
Query: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSL 2078
SN C N C Q+CLP +C C G+ L + SC SF++ S+ IRG L
Sbjct: 1835 SNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPL 1894
Query: 2079 ELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIV 2138
E SD + ++P++G A+ +D + IYW D N I R K D + +I+
Sbjct: 1895 EPSDKMDALMPISGTSF-AVGIDFHAENDTIYWTDMGF-----NKISRAKRDQTWKEDII 1948
Query: 2139 THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVD 2198
T+G+G V GIAVDW+AGN+Y+T+ + LIEV R+N ++R V++ +D PR I V
Sbjct: 1949 TNGLGR--VEGIAVDWIAGNIYWTDHGFN--LIEVARLNGSFRYVIISQGLDQPRSIAVH 2004
Query: 2199 PKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDII 2258
P+ LFW ++GQ P I ++ LD + + VLVS GI P G+++D + +YW D D I
Sbjct: 2005 PEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKI 2064
Query: 2259 ARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDR-NLKKIFQASKEPENTEPPTVI 2316
RI + G N E++ GS + + VF I W DR + + + + TE T+
Sbjct: 2065 ERIDLETGGNREMVLSGSNVDM-FSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMR 2123
Query: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQ 2376
L++V IF++ E N C +NGGC LC G C CA G L
Sbjct: 2124 TGLGVNLKEVKIFNRV------REKGTNVCARDNGGCKQLCL-YRGNSRRTCACAHGYLA 2176
Query: 2377 SDGKNCAISTENFLIFALSNSLRSLHLDPENH--SP--PFQTINVERTVMSLDYD----- 2427
DG C + E +L+++ L+S+HL E + SP P++ + V++L +D
Sbjct: 2177 EDGVTC-LRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRR 2235
Query: 2428 SVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLN 2487
++RI+++ + G I + VI +G+ +G+A+ +Y++
Sbjct: 2236 KGTNRIFYSD---AHFGNIQL--IKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTT 2290
Query: 2488 QMINSMAEDGS-----NRTVIARVPK---PRAIVLDPCQGYLYWADW-DTHAKIERATLG 2538
I D + +R + + + P + LD CQ ++W +W + H I R+TL
Sbjct: 2291 SSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLT 2350
Query: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF-G 2597
G +V++ ++ P+GLT+DY + LY+ D SL +IER G R VIV + F
Sbjct: 2351 GKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS 2410
Query: 2598 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCN-NPCE 2656
L +Y YI+W+D + I R+NKY G + +++ QP GI V N C +PC
Sbjct: 2411 LAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGI-IAVANDTNSCELSPCA 2469
Query: 2657 QFNGGCSHICAPGPNG-AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISE 2715
NGGC +C PNG C C + L +NR C+ N S F C NG CI
Sbjct: 2470 LLNGGCHDLCLLTPNGRVNCSCRGD-RILLEDNR--CVTKNSSCNAYSEFECGNGECIDY 2526
Query: 2716 EWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
+ CD C D SDE C +C C N RC+ + CD NDCGD SDE C
Sbjct: 2527 QLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC 2586
Query: 2776 LFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQ---------SGY 2826
C AT EF C + CIPR CN +C D SDEKNC + C +G+
Sbjct: 2587 KVSTC-ATVEFRCADGTCIPRSARCNQNIDCAD--ASDEKNCNNTDCTHFYKLGVKTTGF 2643
Query: 2827 TKCHNSNICIPRVYLCDGDNDCGDNSDE-NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQ 2885
+C+++++C+ ++CDG NDCGD SDE H C + F C SGRCI W CD
Sbjct: 2644 IRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDG 2703
Query: 2886 ETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN 2945
+ DC D DE H + +C ++F C +CI WICDG++DCGD DE C
Sbjct: 2704 QKDCEDGRDE----FHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI-CGA 2758
Query: 2946 QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE--NQNCT-RRTCSENEFTCGY 3002
C+ F C R C+P+ W+CDG+ DC DG DE C TC EN F C
Sbjct: 2759 ITCAADMFSCQGSRA----CVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
Query: 3003 GLCIPKIFRCDRHNDCGDYSDERG-CLYQTCQQNQFTCQNGRCISKT-FVCDEDNDCGDG 3060
+CIPK F CD +DCGD SDE C Y+ C +F+C +GRC+ T + CD D DC D
Sbjct: 2815 KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDH 2874
Query: 3061 SDE--LMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPS 3118
SDE L C + E +C F C NGRCI LC++ DDC D SDE+ C INEC
Sbjct: 2875 SDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKK 2934
Query: 3119 ISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKC 3178
+SGC +C D S+ C C PG++L D +TCVDIDEC+ F CSQ+C N G+Y C C
Sbjct: 2935 VSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSS-GFPCSQQCINTYGTYKCLC 2993
Query: 3179 APGYLREPDGKT-CRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRV 3237
GY +PD C+ S+ EP+LI ++ + +R ++ DG Y+L+ +GL+NV+A+DFD
Sbjct: 2994 TDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYR 3053
Query: 3238 EKRLYWIDTQR---QVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGL 3294
E+ +YWID+ R I RM LN ++ + + N +P A LAVDW+ + LYW D +
Sbjct: 3054 EEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA--LAVDWIGKNLYWSDTEKRII 3111
Query: 3295 FVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGT 3354
VS LNG + +L + PR L+L PQ GYLYW D +IGRVGMDGT
Sbjct: 3112 EVSKLNGLYPTILVSKRLKF--------PRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGT 3163
Query: 3355 NKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAIT 3414
N+SV+I TK+ P +TIDY N LYWAD + +IE+S+++G HRH V + +P A+T
Sbjct: 3164 NQSVVIETKISRPMALTIDYVNRRLYWADEN--HIEFSNMDGSHRHKVPNQDIPGVIALT 3221
Query: 3415 IFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVS-NPCGTNN 3473
+FED IYWTD T+++ + +K G++R +L+ + H DI VYH YRQP VS + C NN
Sbjct: 3222 LFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINN 3281
Query: 3474 GGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCD 3533
GGCSHLCL+ P GK TC CP +F + + C+ C+++QF C +KCIP WWKCD
Sbjct: 3282 GGCSHLCLLAP-GKTHTCACPTNF--YLAADNRTCLSNCTASQFRC-KTDKCIPFWWKCD 3337
Query: 3534 GQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH 3593
DC DGSDE CP+ C+ G+FQC G C P +C+ +C D SDE L C+ H
Sbjct: 3338 TVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDE--LNCDTHV 3395
Query: 3594 CDSNEWQCA-NKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGR-CIPQA 3651
C S +++C N++CIP + +C+ +DC D +ED C +C P F+C + CI +
Sbjct: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGD--EEDERDCPENSCSPDYFQCKTTKHCISKL 3453
Query: 3652 WKCDVDNDCGDHSDEPIEECMSSAHLCDNFT----EFSCKTNYRCIPKWAVCNGVDDCRD 3707
W CD D DC D SDE CD T EF CK N CIP C+ +DC D
Sbjct: 3454 WVCDEDPDCADASDEA---------NCDKKTCGPHEFQCKNN-NCIPDHWRCDSQNDCSD 3503
Query: 3708 NSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV 3767
NSDE+ C+ +TC + DF C N C+ R+ CDG DC D SDE NC C++ +FRC
Sbjct: 3504 NSDEENCKPQTC-TLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC-ETSCSKDQFRCS 3561
Query: 3768 NQQCIPSRWICDHYNDCGDNSDERDCE--MRTCHPEYFQCTSGHCVHSELKCDGSADCLD 3825
N QCIP++W CD + DC DE+ CE TC + C S C+ + LKC+G DC D
Sbjct: 3562 NGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCAD 3621
Query: 3826 ASDEADCPTRFPD------------------------------------GAYCQATMFEC 3849
SDE DC T + G C+A F C
Sbjct: 3622 GSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLC 3681
Query: 3850 KNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDD 3908
N +C +W CDG+DDCGD SDE +C+ C S RC NNR C+ S ++CNG+D+
Sbjct: 3682 NNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDE 3741
Query: 3909 CGDGTDETEEHC-RKPTPK--PCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN-K 3964
CGD +D E+HC K T K PC + E+ C N CIP D CD DDCGD SDE GC
Sbjct: 3742 CGDNSD--EDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIA 3799
Query: 3965 GKERTCAENI--C--EQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH 4020
E TC +N+ C + C Q+ F C C GF+ N+ +R C D+NEC FGTC
Sbjct: 3800 PTEYTCEDNVNPCGDDAYCNQIKTSVF-CRCKPGFQRNMKNR-QCEDLNECLVFGTCSHQ 3857
Query: 4021 CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVR-----IRKYNLSSERFS 4075
C N +GSY+CVC F ++ C AEGS +L N I +N S +
Sbjct: 3858 CINVEGSYKCVCDQNFQERNN----TCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQ 3913
Query: 4076 -EYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEV 4134
+++ I +D + +D+ +++ T G F KR + GR
Sbjct: 3914 ISHIEHNSRITGMDVYYQ-RDM---IIWSTQFNPGGIF--YKRIH------GREKRQANS 3961
Query: 4135 DLKLKYVMQPDGIAVDWVGRHIYWSDVKNKR---------------IEVAKLDGRYRKWL 4179
L +P IAVDWV +IYW+D I V +L+G L
Sbjct: 3962 GLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRL 4021
Query: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYL 4239
++ +P AIAVNPK G+M+WT G IE A M+G R ILV ++L PTGL++DY
Sbjct: 4022 LTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYF 4081
Query: 4240 NNDRIYWSDFKEDVIETIKYDGTDRRVIAKE---AMNPYSLDIFEDQLYWISKEKGEVWK 4296
++RIYW+DF+ +I ++ YDG++ V ++P+ +DIFED +Y + G V++
Sbjct: 4082 -SERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFR 4139
Query: 4297 QNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI-CSHLCLLRPGGYSCACPQ 4355
KFG G E + V I H+ + +PN C + C LCLL P G +C CP+
Sbjct: 4140 VQKFGHGSVEYLALNIDKTKGVLISHRYK-QLDLPNPCLDLACEFLCLLNPSGATCVCPE 4198
Query: 4356 GSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEM 4412
G I G+ + D+ ++ L C +GG C +E +C C Y+G+ CE+
Sbjct: 4199 GKYLINGTCND-DSLLDDSCKL----TCENGGRCILNEKGDLRCHCWPSYSGERCEV 4250
Score = 639 bits (1647), Expect = 0.0
Identities = 364/1065 (34%), Positives = 537/1065 (50%), Gaps = 110/1065 (10%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADE--IGCAVVTCQQGYFKCQSEGQCIPNSW 85
C + FRC + HCI A W+CDG DC D +DE + C +C FKCQ+ +CIP W
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN-RCIPKRW 903
Query: 86 VCDQDQDCDDGSDE-RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADEN-DCQ 143
+CD DC DE Q C+ TC Q +C NG+CIP + CD DC D DE C+
Sbjct: 904 LCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCE 963
Query: 144 YPTCEQLT---CDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAY 200
+PTCE LT C +G C ++ CD DC D SDE+ C C N+F C +G CIP +
Sbjct: 964 FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHW 1023
Query: 201 VCDHDNDCQDGSDEHACNYPT--------CGGYQFTC-PSGRCIYQNWVCDGEDDCKDNG 251
CD DNDC D SDE N C G +F C P G C+ W CDGE DC+D
Sbjct: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
Query: 252 DEDGCESGPHDVHKCSPR-EWSCPESGRCISIYKVCDGILDCPGREDE------------ 298
DE GC + C + ++SC +GRCI+ VCDG +DC + DE
Sbjct: 1084 DEKGCNG---TIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
Query: 299 ----NNTST--------------------GKYCSMTLCSALNCQYQCHETPYGG-ACFCP 333
N+TS G C + C C P G C CP
Sbjct: 1141 HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP 1200
Query: 334 PGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILE-RGQYCKANDSFG 392
G +N D++TC D C C Q CE C C EG+ L+ G+ C + D F
Sbjct: 1201 EGLQLN-KDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPF- 1258
Query: 393 EASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVD 452
EA IIFS ++ D+H R + +LV +A+ FH++ ++WTD V+++++
Sbjct: 1259 EAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD--FHFNQSLLYWTDVVEDRIYRGK 1316
Query: 453 INGLNIQEVLNVSVE----TPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN 508
++ + V VE TPE L VDW+ IY +++ +++I++ LDGS R TLI
Sbjct: 1317 LSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGA 1376
Query: 509 LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKT-KLG-WPAGVTLDM 566
+ HPR IA+DP G LF++DW++ P++E A M G+ RK + K K G WP G+T+D
Sbjct: 1377 MEHPRAIALDPRYGILFWTDWDA--NFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDH 1434
Query: 567 ISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLK 626
KR+ W D+R D I + YDG ++ G + HPF VSL+ +V++TDW + K
Sbjct: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494
Query: 627 ANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPC--KDNNGGCEQVCVLSHRTDNDG 684
ANK+T N V + S +P+ + +YH RQP A NPC D G C +C+++H
Sbjct: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNR---- 1550
Query: 685 LGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGI-----------PFTLSTQEDVM 733
C C +L +D++ C ++ FL+++ + IRG+ FT+ +DV
Sbjct: 1551 -SAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVT 1609
Query: 734 VPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDW 793
V IDFDA + ++++D+ I + I+GTG E + + ++++ LA DW
Sbjct: 1610 V-----------IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDW 1658
Query: 794 ISKNLYWTDSHY--KSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKI 851
+S+NLYW S + I+V RL + +++ ++ P+ + HP G L++TD I
Sbjct: 1659 VSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTI 1715
Query: 852 MRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHI- 910
A DGS+ ++ P GL+ID+ ++LYW+ + I DG + + +
Sbjct: 1716 NMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMK 1774
Query: 911 EQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTG 970
E++T L I + L++ D L + K DG T++R+ + ++H+K YD Q G
Sbjct: 1775 EELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQG 1834
Query: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEG 1015
SN+C NG CS C P R C C G L N ++C+G
Sbjct: 1835 SNSCQL---NNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQG 1876
Score = 364 bits (934), Expect = 1e-99
Identities = 264/869 (30%), Positives = 401/869 (46%), Gaps = 95/869 (10%)
Query: 1225 RPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPK----TCPSSYFHCDN 1280
R +C EF C + C+ W CDG PDC SDE P+ CP ++ C
Sbjct: 27 RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLG 86
Query: 1281 GN-CIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCP 1339
N C+H + LC+ DC P
Sbjct: 87 TNKCVHLSQLCNGVLDC------------------------------------------P 104
Query: 1340 NGTDESPLCNG--NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDIL 1397
+G DE C ++C N C ++C +C C GF + D ++C+D DEC +
Sbjct: 105 DGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVY 162
Query: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKV---TASESLLLLVASQNKIIADSVTSQ 1454
G+CSQ C N GS+ CSC GY+++ D R+CK +LL+A+ I +
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
Query: 1455 VHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFD-------SS 1507
S V NG+ I +DF I W ++ + T + D S
Sbjct: 223 KMATLSSV-NGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQS 281
Query: 1508 IILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHL 1567
+ +AIDW+ RNLY+ D+ + I V +GS LI L NP+ +A+DP +
Sbjct: 282 FHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGK-- 339
Query: 1568 LFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY 1627
LF++D+G+ ++ER MDG RT I+ K P L +D N+L+Y++D YLDY+ DY
Sbjct: 340 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDY 399
Query: 1628 NGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGN-QSVVMYNIQWP 1686
G +R VI +RH Y +T+FED +Y T+ ++R N+++G + S++ W
Sbjct: 400 QGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW- 457
Query: 1687 LGIVAVHPSKQPN------SVNPCAF-SRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLN 1739
GI QP V+P CSH+CLLSS +C C +G++L D +
Sbjct: 458 -GIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSS-SYKTRTCRCRTGFNLGSDGRS 515
Query: 1740 CLRDDQPFLITV---RQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE 1796
C R + R I+ G+ LN ++ +++ M+PI + N ++F YIY+ +
Sbjct: 516 CKRPKNELFLFYGKGRPGIVRGMDLNTKI-ADEYMIPIENLVNPRALDFHAETNYIYFAD 574
Query: 1797 NPG-EIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNP-RTQSIEVLTLHGDI 1854
I R K DGT R + +A+DWI NLY TN ++I V L
Sbjct: 575 TTSFLIGRQKIDGTERETILKDDLDNVE-GIAVDWIGNNLYWTNDGHRKTINVARLEKAS 633
Query: 1855 RYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTD--SGVPAKIASANMDGTSVKT 1912
+ RKTL+ + + P GI VDP G +YW+D D +I A MDG + +
Sbjct: 634 QSRKTLLEGE-----MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQI 688
Query: 1913 LFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV--HQLSHPWGIAVHD 1970
T + +TLD LYW IE+ ++GT R I+ +L+HP+G++ H
Sbjct: 689 FVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHG 748
Query: 1971 SFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQ 2030
+++++TD I ++D T + +LR P L GLQ+Y R + N C N C
Sbjct: 749 NYVFWTDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQIYDPRK-QQGDNMCRVNNGGCS 806
Query: 2031 QICLPVPGGLFSCACATGFKLNPDNRSCS 2059
+CL +PGG CACA L+ + +C+
Sbjct: 807 TLCLAIPGGRV-CACADNQLLDENGTTCT 834
Score = 348 bits (893), Expect = 7e-95
Identities = 226/787 (28%), Positives = 360/787 (45%), Gaps = 127/787 (16%)
Query: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
+ C C + CIP CDG DC D++DE+ C V TC F+C ++G CIP S
Sbjct: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRC-ADGTCIPRSA 2608
Query: 86 VCDQDQDCDDGSDERQDCSQSTCSSHQ---------ITC-SNGQCIPSEYRCDHVRDCPD 135
C+Q+ DC D SDE+ +C+ + C+ I C S C+ + CD DC D
Sbjct: 2609 RCNQNIDCADASDEK-NCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGD 2667
Query: 136 GADENDCQYPT---CEQ--LTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSC 190
+DE C CE+ +C +G C + CD + DC D DE +C C N+F+C
Sbjct: 2668 YSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFAC 2727
Query: 191 GNGECIPRAYVCDHDNDCQDGSDE--HACNYPTCGGYQFTCPSGR-CIYQNWVCDGEDDC 247
+CI + ++CD ++DC DG DE C TC F+C R C+ ++W+CDGE DC
Sbjct: 2728 SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDC 2787
Query: 248 KDNGDE--------------------------------------DGCESGPH-DVHKCSP 268
D DE DG + P +C
Sbjct: 2788 PDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGT 2847
Query: 269 REWSCPESGRC-ISIYKVCDGILDCPGREDE----------------------------- 298
E+SC + GRC ++ CDG DCP DE
Sbjct: 2848 EEFSCAD-GRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPS 2906
Query: 299 ----------NNTSTGKYCSMTLC---SALNCQYQCHETPYGGACFCPPGYIINHNDSRT 345
+ S + C + C C C + P C C PG+ + +D +T
Sbjct: 2907 GGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLK-DDGKT 2965
Query: 346 CVEFDDCQIWGICDQKCESRPGRHLCHCEEGYIL--ERGQYCKANDSFGEASIIFSNGRD 403
CV+ D+C C Q+C + G + C C +GY + + CK+ S E +I ++ +
Sbjct: 2966 CVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSL-SDEEPFLILADHHE 3024
Query: 404 LLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQ---NKVFSVDINGLNIQE 460
+ G ++ +L + N +A+ F Y + ++W D+ + +++ + +NG +I+
Sbjct: 3025 IRKISTDGSNYTLLKQGLNNVIAID--FDYREEFIYWIDSSRPNGSRINRMCLNGSDIKV 3082
Query: 461 VLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPT 520
V N +V P LAVDW+ +Y +T+ I++ L+G Y L+++ L PR +++DP
Sbjct: 3083 VHNTAV--PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQ 3140
Query: 521 VGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDY 580
GYL+ W P + R MDG+N+ +++TK+ P +T+D +++R+YW D ++
Sbjct: 3141 AGYLY---WIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADE--NH 3195
Query: 581 IETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQ 640
IE DG R V + IP ++LFE +++TD ++ +A+K + +
Sbjct: 3196 IEFSNMDGSHRHKVPNQD--IPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 3253
Query: 641 ASLRPYGVTVYHSLRQP-YATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDT 699
+ + VYHS RQP + + C NNGGC +C+L+ G C C F L
Sbjct: 3254 SWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLA-----PGKTHTCACPTNFYLAA 3308
Query: 700 DERHCIA 706
D R C++
Sbjct: 3309 DNRTCLS 3315
Score = 326 bits (836), Expect = 3e-88
Identities = 226/748 (30%), Positives = 335/748 (44%), Gaps = 105/748 (14%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87
C F+C + +CIP WRCD DCSD++DE C TC F C + G C+ + + C
Sbjct: 3476 CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLC-ANGDCVSSRFWC 3534
Query: 88 DQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ--YP 145
D D DC DGSDER +++CS Q CSNGQCIP++++CD DC G DE C+ P
Sbjct: 3535 DGDFDCADGSDERN--CETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
Query: 146 TCE--QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN-GECIPRAYVC 202
TC + C + C + S KC+ + DC D SDE++C C ++F C N CIP ++C
Sbjct: 3593 TCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLC 3652
Query: 203 DHDNDCQDGSDEHACNYP--TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE--DGCES 258
D +DC DGSDE C C +F C + C WVCDGEDDC DN DE D C
Sbjct: 3653 DGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVK 3712
Query: 259 GPHDVHKC-SPREWSCPESGRCISIYKVCDGILDC------------------PGREDEN 299
C S R C + C+ ++C+GI +C P ++DE
Sbjct: 3713 -----FLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEF 3767
Query: 300 NTSTGKYCSMTL----------------CSALNCQYQCHET--PYGGA-----------C 330
S K M L C +Y C + P G C
Sbjct: 3768 ACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFC 3827
Query: 331 FCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDS 390
C PG+ N + R C + ++C ++G C +C + G + C C++ + ER C A S
Sbjct: 3828 RCKPGFQRNMKN-RQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNF-QERNNTCIAEGS 3885
Query: 391 FGEASIIFSNGRDLLIGDIHGRSF----RILVESQNRGVAVGVAFHYHLQRVFW-TDTVQ 445
+ I +N D+L G I+ ++ + + ++ G+ +Y + W T
Sbjct: 3886 EDQVLYI-ANDTDIL-GFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNP 3943
Query: 446 NKVFSVDINGLNIQE----VLNVSVETPENLAVDWVNNKIYLVE--------------TK 487
+F I+G ++ ++ + P ++AVDWV IY + T
Sbjct: 3944 GGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTS 4003
Query: 488 VN-RIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGS 546
+ I++ L+G L+T G P IAV+P G ++ W + +E A MDG+
Sbjct: 4004 LRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMY---WTVVGDHSHIEEAAMDGT 4060
Query: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
R+ LV+ L P G+ +D S+R+YW D I +V YDG V + HP
Sbjct: 4061 LRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHR 4120
Query: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
+ +FE ++ K V + KF + + + GV + H +Q NPC D
Sbjct: 4121 IDIFEDYIYGAG-PKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL 4179
Query: 667 NGGCEQVCVLSHRTDNDGLGFRCKCTFG 694
CE +C+L+ G C C G
Sbjct: 4180 --ACEFLCLLNPS------GATCVCPEG 4199
Score = 236 bits (602), Expect = 4e-61
Identities = 118/321 (36%), Positives = 150/321 (46%), Gaps = 51/321 (15%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIP----- 82
C F+CG+G C + CDG DC D++DE+ C C G FKC +CIP
Sbjct: 3357 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRC 3416
Query: 83 -----------------NS------------------WVCDQDQDCDDGSDERQDCSQST 107
NS WVCD+D DC D SDE +C + T
Sbjct: 3417 NGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDE-ANCDKKT 3475
Query: 108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCD 165
C H+ C N CIP +RCD DC D +DE +C+ TC + C NG C ++ CD
Sbjct: 3476 CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCD 3535
Query: 166 WKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACN--YPTCG 223
DC D SDE NC C ++F C NG+CIP + CD DC+ G DE +C PTC
Sbjct: 3536 GDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCS 3595
Query: 224 GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
++ C S CI + C+GE DC D DE C V +C ++ C CI I
Sbjct: 3596 SREYICASDGCISASLKCNGEYDCADGSDEMDC------VTECKEDQFRCKNKAHCIPIR 3649
Query: 284 KVCDGILDCPGREDENNTSTG 304
+CDGI DC DE N G
Sbjct: 3650 WLCDGIHDCVDGSDEENCERG 3670
Score = 209 bits (533), Expect = 4e-53
Identities = 115/330 (34%), Positives = 165/330 (50%), Gaps = 33/330 (10%)
Query: 31 AHFRCGSGHCIPADWRCDGTKDCSDDADE--IGCAVVTCQQGYFKCQSEGQCIPNSWVCD 88
+ F CG+G CI CDG C D +DE + C +C++G+ C + +CIP+ +CD
Sbjct: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR-RCIPHGKLCD 2572
Query: 89 QDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148
+ DC D SDE DC STC++ + C++G CIP RC+ DC D +DE +C C
Sbjct: 2573 GENDCGDNSDE-LDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
Query: 149 Q-----------LTCDN-GACYNTSQKCDWKVDCRDSSDEINC----TEICLHNEFSCGN 192
+ C++ C + CD DC D SDE+ C C N FSC +
Sbjct: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS 2691
Query: 193 GECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252
G CI ++CD DC+DG DE C+ +C QF C + +CI ++W+CDGEDDC D D
Sbjct: 2692 GRCILNTWICDGQKDCEDGRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLD 2750
Query: 253 EDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLC 312
E G C+ +SC S C+ + +CDG DCP DE +T+ C+
Sbjct: 2751 ESDSICG---AITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAG---CAPNNT 2804
Query: 313 SALNCQYQCHETPYGGACFCPPGYIINHND 342
N + CH C P ++ +H+D
Sbjct: 2805 CDENA-FMCHNK----VCI-PKQFVCDHDD 2828
Score = 207 bits (528), Expect = 1e-52
Identities = 125/392 (31%), Positives = 167/392 (42%), Gaps = 74/392 (18%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGT------------------------------------- 50
C ++ FRC + CIP W+CD
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC 3376
Query: 51 ---KDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST 107
DC D++DE+ C C G FKC +CIP + C+ DC D DER DC +++
Sbjct: 3377 DGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDER-DCPENS 3435
Query: 108 CSSHQITC-SNGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKC 164
CS C + CI + CD DC D +DE +C TC + C N C +C
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRC 3495
Query: 165 DWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCG 223
D + DC D+SDE NC + C +F C NG+C+ + CD D DC DGSDE C +C
Sbjct: 3496 DSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCE-TSCS 3554
Query: 224 GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
QF C +G+CI W CDG +DCK DE CE CS RE+ C G CIS
Sbjct: 3555 KDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPAS---PTCSSREYICASDG-CISAS 3610
Query: 284 KVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDS 343
C+G DC DE + T C C+ + H P C +
Sbjct: 3611 LKCNGEYDCADGSDEMDCVT--ECKE---DQFRCKNKAHCIPIRWLC----------DGI 3655
Query: 344 RTCVEFDDCQIWGICDQKCESRPGRHLCHCEE 375
CV+ D ++ CE G ++C +E
Sbjct: 3656 HDCVDGSD-------EENCER--GGNICRADE 3678
Score = 182 bits (463), Expect = 5e-45
Identities = 96/266 (36%), Positives = 131/266 (49%), Gaps = 13/266 (4%)
Query: 57 ADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCS 116
AD C + C F+C+++ +CIP W CD DC DGSDE DC + C + C
Sbjct: 3308 ADNRTC-LSNCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCG 3365
Query: 117 NGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTC-DNGACYNTSQKCDWKVDCRDS 173
G C + CD DC D +DE +C C Q C N C + +C+ + DC D
Sbjct: 3366 TGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDE 3425
Query: 174 SDEINCTE-ICLHNEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS 231
DE +C E C + F C + CI + +VCD D DC D SDE C+ TCG ++F C +
Sbjct: 3426 EDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKN 3485
Query: 232 GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
CI +W CD ++DC DN DE+ C+ C+ +++ C +G C+S CDG D
Sbjct: 3486 NNCIPDHWRCDSQNDCSDNSDEENCKP-----QTCTLKDFLC-ANGDCVSSRFWCDGDFD 3539
Query: 292 CPGREDENNTSTGKYCSMTLCSALNC 317
C DE N T CS C
Sbjct: 3540 CADGSDERNCETSCSKDQFRCSNGQC 3565
Score = 177 bits (450), Expect = 2e-43
Identities = 137/511 (26%), Positives = 224/511 (43%), Gaps = 40/511 (7%)
Query: 3870 GSDEELHLCLDVPCNSPNRFRC-DNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPC 3928
G+D + LC P F C D+ C+ +C+G DC D +DE+ + C + C
Sbjct: 24 GADRDQQLC------DPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKC 77
Query: 3929 TEYEYKC-GNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGF 3987
C G C+ +C+ DC D DE + C + C+ CT +
Sbjct: 78 PLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTR 137
Query: 3988 ICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
C C GFE D SC D +EC +GTC Q CRNT GSY C C +G+ D +
Sbjct: 138 -CYCEDGFEITE-DGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKA 195
Query: 4048 AAEGSS--PLLLLPDNVRIRKYNLSSERFSEYLQ-DEEYIQAVDYDWDPKDIGLSVVYYT 4104
E + P+LL+ + I + L+ + + + I +D+ ++ + +
Sbjct: 196 KIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNED----MICWIE 251
Query: 4105 VRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLK-LKYVMQPDGIAVDWVGRHIYWSDVKN 4163
R ++ I+ + L E + L+ +A+DW+ R++Y+ D
Sbjct: 252 SRESSNQLKCIQ-------ITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVG 304
Query: 4164 KRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNIL 4223
RI V +G LI +L P AIAV+P G +F+TD+G K+E M+G +R +
Sbjct: 305 DRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRI 364
Query: 4224 VFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVI--AKEAMNPYSLDIFE 4281
+ P L++D L N +YW D D + + Y G +R + ++ + Y + +FE
Sbjct: 365 IDSKTEQPAALALD-LVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFE 423
Query: 4282 DQLYWISKEKGEVWKQNKF-GQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI--- 4337
D LY + + + + N+F G + N W +RI+ Q R +V + ++
Sbjct: 424 DYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW--GIRIY-QKRTQPTVRSHACEVDPY 480
Query: 4338 -----CSHLCLLRPGGYSCACPQGSSFIEGS 4363
CSH+CLL + C + F GS
Sbjct: 481 GMPGGCSHICLLSSSYKTRTCRCRTGFNLGS 511
Score = 166 bits (421), Expect = 4e-40
Identities = 108/344 (31%), Positives = 153/344 (44%), Gaps = 45/344 (13%)
Query: 72 FKCQSEGQCIPNSWVCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCIPSEYRCDHV 130
F+C G+CI CD C D SDE+ C +C C N +CIP CD
Sbjct: 2516 FEC-GNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
Query: 131 RDCPDGADENDCQYPTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI-CLH-- 185
DC D +DE DC+ TC + C +G C S +C+ +DC D+SDE NC C H
Sbjct: 2575 NDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFY 2634
Query: 186 -------NEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHAC---NYPTCGGYQFTCPSGRC 234
C + C+ ++CD NDC D SDE C N C F+CPSGRC
Sbjct: 2635 KLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRC 2694
Query: 235 IYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPG 294
I W+CDG+ DC+D DE C+S CS +++C + +CIS + +CDG DC
Sbjct: 2695 ILNTWICDGQKDCEDGRDEFHCDS------SCSWNQFAC-SAQKCISKHWICDGEDDCGD 2747
Query: 295 REDENNTSTGKYCSMTLCSALNC---QYQCHETPYGGACFCPPGYIINHNDSRTCVEFDD 351
DE++ ++C A+ C + C G+ C P + + + R C + D
Sbjct: 2748 GLDESD---------SICGAITCAADMFSCQ-----GSRACVPRHWLCDGE-RDCPDGSD 2792
Query: 352 CQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEAS 395
C +CH + + C +D G+ S
Sbjct: 2793 ELSTAGCAPNNTCDENAFMCH--NKVCIPKQFVCDHDDDCGDGS 2834
Score = 122 bits (307), Expect = 6e-27
Identities = 87/276 (31%), Positives = 122/276 (44%), Gaps = 53/276 (19%)
Query: 25 GQECDSAHFRCGSGHCIPADWRCDGT-------------KDCSDDADEI---GCAV-VTC 67
G D + CG+ C + C G+ +DC D +DE+ GCA TC
Sbjct: 2746 GDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTC 2805
Query: 68 QQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC-IPSEYR 126
+ F C ++ CIP +VCD D DC DGSDE C C + + +C++G+C + ++++
Sbjct: 2806 DENAFMCHNK-VCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ 2864
Query: 127 CDHVRDCPDGADENDCQYPTCEQ---------LTCDNGACYNTSQKCDWKVDCRDSSDEI 177
CD DCPD +DE P C+ C NG C + CD K DC D SDE
Sbjct: 2865 CDGDFDCPDHSDEAPLN-PKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDER 2923
Query: 178 NC-TEICLHNEFSCGNGEC--IPRAYVC---------DHDNDCQDGSDEHACNYP----- 220
NC CL + S + +C +P +Y C D C D DE + +P
Sbjct: 2924 NCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD-IDECSSGFPCSQQC 2982
Query: 221 --TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDED 254
T G Y+ C G I D + CK DE+
Sbjct: 2983 INTYGTYKCLCTDGYEIQP----DNPNGCKSLSDEE 3014
Score = 110 bits (275), Expect = 3e-23
Identities = 147/592 (24%), Positives = 220/592 (37%), Gaps = 106/592 (17%)
Query: 2334 QPRSPAEVNNNPCLENN-----GGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTEN 2388
+P + N C + N G CSH C + G + CD F Q C
Sbjct: 3830 KPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNF---QERNNTCIAEGSE 3886
Query: 2389 FLIFALSNSLRSL-HLDPENHSPPFQTIN-VERTVMSLDYDSVSDRIYFTQNLASGVGQI 2446
+ ++N L + P N+S Q I+ +E D R + G I
Sbjct: 3887 DQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGI 3946
Query: 2447 SYATL--------SSGIHTPTVIASGIGTADGIAFDWITRRIYYSDY------------- 2485
Y + +SG+ P IA DW+ IY++D+
Sbjct: 3947 FYKRIHGREKRQANSGLICPE-----FKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHW 4001
Query: 2486 --LNQMINSMAEDGSN--RTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
L IN +G N R + +P AI ++P +G +YW H+ IE A + G
Sbjct: 4002 TSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTL 4061
Query: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AVHAFGL 2598
R +V +L P+GL +DY + +YW D L I G + V V++ +H +
Sbjct: 4062 RRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRI 4121
Query: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQF 2658
++ YIY ++R K+ G G + + + +G+ + ++ NPC
Sbjct: 4122 DIFEDYIYGAG-PKNGVFRVQKF-GHGSVEYLALNIDKTKGVLISHRYKQLDLPNPC--L 4177
Query: 2659 NGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSN-GRCISEE- 2716
+ C +C P+GA C CP EG YL N + D+ + TC N GRCI E
Sbjct: 4178 DLACEFLCLLNPSGATCVCP-EGK-YLINGTCN---DDSLLDDSCKLTCENGGRCILNEK 4232
Query: 2717 -------W------KCDND---NDCGDGSDEMESVCALHTCS-PTAFT------------ 2747
W +C+ + N C +G + SV TCS FT
Sbjct: 4233 GDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
Query: 2748 CAN-GRCV-----------QYSY---RCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRR 2792
C N G C+ Q Y RC YY + C D + + E +C R
Sbjct: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGD-DGSVECVCPTRY 4351
Query: 2793 CIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDG 2844
P+ + V CH + K+ D C C N I LCDG
Sbjct: 4352 EGPKCEVDKCV-RCHGGHCIINKDSEDIFC-----NCTNGKIA-SSCQLCDG 4396
Score = 107 bits (267), Expect = 3e-22
Identities = 74/270 (27%), Positives = 97/270 (35%), Gaps = 75/270 (27%)
Query: 100 RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
R +CS C +I + +C+ C+ + C NG C +
Sbjct: 2486 RVNCS---CRGDRILLEDNRCVTKNSSCN-----------------AYSEFECGNGECID 2525
Query: 160 TSQKCDWKVDCRDSSDE--INCTEICLHNEFS-CGNGECIPRAYVCDHDNDCQDGSDEHA 216
CD C+D SDE + C F C N CIP +CD +NDC D SDE
Sbjct: 2526 YQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELD 2585
Query: 217 CNYPTCGGYQFTCPSGRCIYQN-------------------------------------- 238
C TC +F C G CI ++
Sbjct: 2586 CKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIR 2645
Query: 239 -----------WVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCD 287
W+CDG +DC D DE C + HKC +SCP SGRCI +CD
Sbjct: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCP--VQNKHKCEENYFSCP-SGRCILNTWICD 2702
Query: 288 GILDCPGREDENNTSTGKYCSMTLCSALNC 317
G DC DE + + + CSA C
Sbjct: 2703 GQKDCEDGRDEFHCDSSCSWNQFACSAQKC 2732
Score = 97.1 bits (240), Expect = 4e-19
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 11/159 (6%)
Query: 173 SSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE-HACNYPTCGGYQFTCPS 231
++D C C ++F C +CIP + CD +DC DGSDE C C +F C +
Sbjct: 3307 AADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
Query: 232 GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
G C ++CDGE+DC DN DE C D H C ++ C ++ +CI + C+G D
Sbjct: 3367 GLCALPAFICDGENDCGDNSDELNC-----DTHVCLSGQFKCTKNQKCIPVNLRCNGQDD 3421
Query: 292 CPGRED-----ENNTSTGKYCSMTLCSALNCQYQCHETP 325
C ED EN+ S + T ++ + C E P
Sbjct: 3422 CGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP 3460
Score = 94.0 bits (232), Expect = 3e-18
Identities = 155/642 (24%), Positives = 237/642 (36%), Gaps = 93/642 (14%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERH--CIAV---QNFLIFSSQV 717
C+D N C SH+ N ++C C FQ ER+ CIA L ++
Sbjct: 3842 CEDLNE-CLVFGTCSHQCINVEGSYKCVCDQNFQ----ERNNTCIAEGSEDQVLYIANDT 3896
Query: 718 AIRGI--PFTLSTQEDVMVPVSGNPSFFVGID-FDAQDSTIFFSDMSKHMIFKQKIDGTG 774
I G PF S + + N S G+D + +D I+ + + IF ++I G
Sbjct: 3897 DILGFIYPFNYSGDHQQISHIEHN-SRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHG-- 3953
Query: 775 REILAAN------RVENVESLAFDWISKNLYWTD-------SHYK--------SISVMRL 813
RE AN + +A DW++ N+YWTD S+Y SI+V +L
Sbjct: 3954 REKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQL 4013
Query: 814 -ADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWP 872
R + P ++ V+P G +++T + I A DG+ ++ L P
Sbjct: 4014 NGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRP 4073
Query: 873 NGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR-RRLGHIEQMTHPFGLAIFGEHLFFTDW 931
GLA+D+ + R+YW D I +DG + + + + HP + IF ++++
Sbjct: 4074 TGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGP 4133
Query: 932 RLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNG----DCSHF 987
+ G + RV+K G + + I K+ V I S+ Q PN C
Sbjct: 4134 KNG-VFRVQKFGHGSVEYLALNID-----KTKGVLI---SHRYKQLDLPNPCLDLACEFL 4184
Query: 988 CFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKN-GRCVPN----- 1041
C P+ C CP G L + TC D + + C L C+N GRC+ N
Sbjct: 4185 CLLNPS-GATCVCPEGKYLING--TCNDDSLLD---DSCKL---TCENGGRCILNEKGDL 4235
Query: 1042 ---YYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-----TCGHGECIPAHWRCDKRNDCV 1093
+ + C N C TC S +C G P + + C
Sbjct: 4236 RCHCWPSYSGERCEVNHCSNYCQN-GGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQ 4294
Query: 1094 DGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ 1153
+G + P +YT D Q + C C G D S E P++
Sbjct: 4295 NGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDD----GSVECVCPTR 4350
Query: 1154 FNCPNHRC-IDLSFVCDGDKDCVDGSDEVGCVLNCTASQFK---------CASGDKCIGV 1203
+ P +C +D C G C+ D NCT + C +G C
Sbjct: 4351 YEGP--KCEVDKCVRCHGG-HCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLD 4407
Query: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIP 1245
V CS N C P SD + I +P
Sbjct: 4408 PETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVP 4449
Score = 90.9 bits (224), Expect = 3e-17
Identities = 53/142 (37%), Positives = 69/142 (48%), Gaps = 12/142 (8%)
Query: 182 ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA--CNYPTCGGYQFTCPSGRCIYQNW 239
IC EF C N CI + CD D+DC DGSDE + C +C QF C + RCI + W
Sbjct: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRW 903
Query: 240 VCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDEN 299
+CDG +DC N DE + C ++SC +GRCI +CD DC + DE
Sbjct: 904 LCDGANDCGSNEDE---SNQTCTARTCQVDQFSC-GNGRCIPRAWLCDREDDCGDQTDEM 959
Query: 300 NTSTGKYCSMTLCSALNCQYQC 321
+ C C L Q+ C
Sbjct: 960 AS-----CEFPTCEPLT-QFVC 975
Score = 86.3 bits (212), Expect = 7e-16
Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 33/220 (15%)
Query: 25 GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGY-FKCQSEGQCI 81
G C + F C + C W CDG DC D++DE C C +C++ C+
Sbjct: 3671 GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICL 3730
Query: 82 PNSWVCDQDQDCDDGSDERQDCSQST-----CSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
+ +C+ +C D SDE + T C + CSN +CIP + +CD + DC DG
Sbjct: 3731 QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDG 3790
Query: 137 ADENDCQYP----TCEQLT--CDNGACYN---TSQKCDWKV---------DCRDSSDEI- 177
+DE C+ TCE C + A N TS C K C D ++ +
Sbjct: 3791 SDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLV 3850
Query: 178 --NCTEICLHNEFSCGNGECIPRAYVCDHDNDC-QDGSDE 214
C+ C++ E G+ +C+ + +N C +GS++
Sbjct: 3851 FGTCSHQCINVE---GSYKCVCDQNFQERNNTCIAEGSED 3887
Score = 71.6 bits (174), Expect = 2e-11
Identities = 52/152 (34%), Positives = 69/152 (45%), Gaps = 22/152 (14%)
Query: 3511 MCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQRF---CRLGQFQCSDGN-C 3565
+C +FLC ++ C+ W CDG DC D SDE L CP+ C L C N C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 3566 TSPQTLCNAHQNCPDGSDE----DRLL--CENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
LCN +CPDG DE LL C+ +C +++C R + D F
Sbjct: 91 VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDGFEIT 147
Query: 3620 ED-NSDEDSSHCA-----SRTCR--PGQFRCA 3643
ED S +D CA S+TCR G + C+
Sbjct: 148 EDGRSCKDQDECAVYGTCSQTCRNTHGSYTCS 179
Score = 70.9 bits (172), Expect = 3e-11
Identities = 47/151 (31%), Positives = 64/151 (42%), Gaps = 31/151 (20%)
Query: 26 QECDSAHFRCGSG-HCIPADWRCDGTKDCSDDADEI--GC---AVVTCQQGYFKCQSEGQ 79
Q CD F C C+ W CDG DC DD+DE C + C + C +
Sbjct: 30 QLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNK 89
Query: 80 CIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRD-----CP 134
C+ S +C+ DC DG DE C + + Q+ C +Y+C VR+ C
Sbjct: 90 CVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC--------QYKCTMVRNSTRCYCE 141
Query: 135 DG----------ADENDCQ-YPTCEQLTCDN 154
DG D+++C Y TC Q TC N
Sbjct: 142 DGFEITEDGRSCKDQDECAVYGTCSQ-TCRN 171
Score = 70.1 bits (170), Expect = 5e-11
Identities = 50/163 (30%), Positives = 67/163 (41%), Gaps = 27/163 (16%)
Query: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQST---CSSHQITC-SNGQCI 121
C G F C C+ SW+CD D DC D SDE D C + C + I C +C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 122 PSEYRCDHVRDCPDGADEN-DCQ--YPTCEQLTCD-NGACYNTSQKC------DWKVDCR 171
C+ V DCPDG DE CQ C+QL C S +C + D R
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
Query: 172 DSSDEI------NCTEIC--LHNEFSCGNGECIPRAYVCDHDN 206
D+ C++ C H ++C C+ Y+ DN
Sbjct: 152 SCKDQDECAVYGTCSQTCRNTHGSYTC---SCV-EGYLMQPDN 190
Score = 41.6 bits (96), Expect = 0.019
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 4383 CMHGGNCYFD-ETDLPKCKCPSGYTGKYCEM---AFSKGISPGTTAVAVLLTILLIVVIG 4438
C +GG C D ET++P C C + ++G CE SK T ++A+++ ++L+V +
Sbjct: 4398 CYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLI 4457
Query: 4439 ALAIAGFFHYRR 4450
+ G +R
Sbjct: 4458 TTLVIGLVLCKR 4469
Score = 35.8 bits (81), Expect = 1.0
Identities = 43/170 (25%), Positives = 58/170 (34%), Gaps = 37/170 (21%)
Query: 19 CLAPASGQECDSAH---FRCGSGHCIPADW---RCD----------GTKDCSDDADEIGC 62
C SG+ C+ H + G C+P+ C G C D G
Sbjct: 4239 CWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGT 4298
Query: 63 AVVTC-QQGYFKCQSEG-----QCIPNSWVCDQDQDCDDGSDERQDCSQST------CSS 110
+VT Q Y CQ E Q C + C G D +C T C
Sbjct: 4299 CIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEV 4358
Query: 111 HQ-ITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
+ + C G CI ++ D +C +G + CQ CD G CYN
Sbjct: 4359 DKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQ-------LCD-GYCYN 4400
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 1065 bits (2755), Expect = 0.0
Identities = 614/1686 (36%), Positives = 904/1686 (53%), Gaps = 93/1686 (5%)
Query: 1022 PTEQCGLFSFPCKNGR-----CVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGH 1076
P CG F C C+P + CDG +DC D+SDE C + TCS F C +
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC--ILPTCSPLDFHCDN 80
Query: 1077 GECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGD 1136
G+CI W CD NDC D SDE +CP P C + ++ C N CI W CD DNDCGD
Sbjct: 81 GKCIRRSWVCDGDNDCEDDSDEQDCP---PRECEEDEFPCQNGYCIRSLWHCDGDNDCGD 137
Query: 1137 GSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC-----VLNCTASQ 1191
SDE+ C+ + C +F C + CI + CDGD DC DGSDE C C +
Sbjct: 138 NSDEQ-CDMRK-CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEE 195
Query: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECD 1251
F+CA G +CI CDG DC D SDE+ C + P C S EF C + G+CI W CD
Sbjct: 196 FQCAYG-RCILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMC-DSGLCINAGWRCD 251
Query: 1252 GHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP-TQPF 1310
G DC SDE N C C + F C +G C+ +W CD ++DC D SDE++C T
Sbjct: 252 GDADCDDQSDERN-CTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSP 310
Query: 1311 RCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCN------GNSCSDFNGGCTHEC 1364
+C Q+ C C+ +C+G+ DC + +DESP N +C+ NGGC +C
Sbjct: 311 QCALDQFLCWNGR-CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKC 369
Query: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424
+C C G+ L D TC+D++EC G CSQ C N G+F+C C+TGY L D
Sbjct: 370 QMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPD 429
Query: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
R+CK E +LL N+I V L+ N +A+DF +FWSD
Sbjct: 430 RRSCKALGPEPVLLFA---NRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSD 486
Query: 1485 ATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRT 1544
T + A NG++ V + + +A+DWV LYWTD IEV+ +DG+HR
Sbjct: 487 VTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRK 546
Query: 1545 VLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLT 1604
VL+ +NL PR +AL P E ++W+DWG+ PRIE +SMDGS R +I +FWP GLT
Sbjct: 547 VLLWQNLEKPRAIALHPM--EGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLT 604
Query: 1605 IDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRR 1664
IDY R +Y++D+ ++ + +G HR+ VI+ L HP+A+T+FEDS+YWTD T+
Sbjct: 605 IDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGL--PHPFAITVFEDSLYWTDWHTKS 662
Query: 1665 VMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGPHF 1722
+ ANK+ G NQ ++ + +P+ I +HP +QP N C + C+HLCL S Q
Sbjct: 663 INSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN--- 719
Query: 1723 YSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLD 1782
Y+C CP+G+ C + FL+ R+ I IS + E S+D ++P+A +++ +
Sbjct: 720 YTCACPTGFRKISSHA-CAQSLDKFLLFARRMDIRRISFDTEDLSDD-VIPLADVRSAVA 777
Query: 1783 VEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPR 1841
+++D + ++YW + + I R K DGT + V S+ P+ LA+DW++ LY T+
Sbjct: 778 LDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPA-GLAIDWVTNKLYWTDAG 836
Query: 1842 TQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIA 1901
T IEV G +R T++ + + P I V+P G +YW TD G KI
Sbjct: 837 TDRIEVANTDGSMR---TVLIWEN----LDRPRDIVVEPMGGYMYW----TDWGASPKIE 885
Query: 1902 SANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILV-HQL 1960
A MD + + + + NL + +D Q+LYWA G IE +DG+ R +L+ QL
Sbjct: 886 RAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 945
Query: 1961 SHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSN 2020
HP+G+ ++ +Y+TD Q + I+ D+ TG ++ L++N+ NL + V+HRR S+
Sbjct: 946 PHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTP 1005
Query: 2021 GCSNNMNACQQICL--PVPGGLFSCACATGFKLNPDNRSCSP-YNSFIVVSMLSAIRGFS 2077
C+ C +CL P P G FSC C TG L D ++CSP NSF++ + IR S
Sbjct: 1006 -CAMENGGCSHLCLRSPNPSG-FSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVS 1063
Query: 2078 LELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNI 2137
L++ ++ +VP+ +N + + VD G +YW D ++ + I R DGS +I
Sbjct: 1064 LDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSD-----STLHRISRANLDGSQHEDI 1118
Query: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197
+T G+ G+AVD + +Y+T+ + IEV ++ + R+VL+ +D PR IV+
Sbjct: 1119 ITTGLQTTD--GLAVDAIGRKVYWTDTGTNR--IEVGNLDGSMRKVLVWQNLDSPRAIVL 1174
Query: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257
+ +++W D+G+ K+ERS +D ++R VL++ + P GL VD++ + W D +
Sbjct: 1175 YHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTER 1234
Query: 2258 IARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIR 2317
I +NG N + S PYG+T+ ++ I W D + I +A K + ++R
Sbjct: 1235 IEAADLNGANRHTLV--SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV--ILVR 1290
Query: 2318 DNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGT-LQ 2376
N+ L D+ D+ QP + N C NGGCSHLC P + C C G L+
Sbjct: 1291 SNLPGLMDMQAVDR-AQP-----LGFNKCGSRNGGCSHLCLPRPSGFS--CACPTGIQLK 1342
Query: 2377 SDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFT 2436
DGK C S E +L+F+ S+R + LD +H+ + V+SLDYDSV ++Y+T
Sbjct: 1343 GDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYT 1402
Query: 2437 QNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAED 2496
+ + +G + TVI G+ T DG+A DW+ R +Y++D I + D
Sbjct: 1403 DVFLDVIRRADL----NGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLD 1458
Query: 2497 GSNRTVIAR--VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPS 2554
GS R V+ + +PRAI + P +GYL+W DW AKIERA L G+ R ++N+ L P+
Sbjct: 1459 GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPN 1518
Query: 2555 GLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQR 2614
GLTLDY+ +YWVDA L RIE + L G R+V+V+ H F LT ++IYWTD T+
Sbjct: 1519 GLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKS 1578
Query: 2615 IYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAE 2674
I R +KY G + + N+ I VV Q+Q N C NGGC+H+C +
Sbjct: 1579 IQRVDKYSGRNKETVLANVEGLMDII--VVSPQRQTGTNACGVNNGGCTHLCFARASDFV 1636
Query: 2675 CQCPHE 2680
C CP E
Sbjct: 1637 CACPDE 1642
Score = 673 bits (1736), Expect = 0.0
Identities = 362/1010 (35%), Positives = 537/1010 (53%), Gaps = 47/1010 (4%)
Query: 19 CLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEG 78
C+ P C F C +G CI W CDG DC DD+DE C C++ F CQ+ G
Sbjct: 66 CILPT----CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN-G 120
Query: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGAD 138
CI + W CD D DC D SDE+ C CS + CS+G CI + CD DC DG+D
Sbjct: 121 YCIRSLWHCDGDNDCGDNSDEQ--CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
Query: 139 ENDCQY----PTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT--EICLHNEFSC 190
E +C P C E+ C G C CD DC D SDE +C+ + C EF C
Sbjct: 179 EENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC 238
Query: 191 GNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDN 250
+G CI + CD D DC D SDE C C QF C SGRC+ +W CDGEDDC DN
Sbjct: 239 DSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADN 298
Query: 251 GDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK-YCSM 309
DE+ CE+ +C+ ++ C +GRCI K+C+G+ DC DE+ +
Sbjct: 299 SDEENCENTGSP--QCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGE 355
Query: 310 TLCSALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPG 367
C+ N C +C C C GY + D TC + ++C G C Q C + G
Sbjct: 356 ENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTE-DGHTCQDVNECAEEGYCSQGCTNSEG 414
Query: 368 RHLCHCEEGYILERGQY-CKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVA 426
C CE GY L + CKA E ++F+N D+ H + +L+ + +A
Sbjct: 415 AFQCWCETGYELRPDRRSCKALGP--EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIA 472
Query: 427 VGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVET 486
+ FH+ + VFW+D +++ ++NG N++EV++ +E+P LAVDWV++K+Y ++
Sbjct: 473 LD--FHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDS 530
Query: 487 KVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGS 546
+RI++ NLDG++R L+ +NL PR IA+ P G ++++DW P++E + MDGS
Sbjct: 531 GTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW---GNTPRIEASSMDGS 587
Query: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
R+ + T L WP G+T+D +R+YWVD++ IE DG RK V+ G +PHPF
Sbjct: 588 GRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFA 645
Query: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
+++FE +++TDW ++ ANKFT N ++ P + H RQP N C DN
Sbjct: 646 ITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN 705
Query: 667 NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTL 726
NGGC +C+ S G + C C GF+ + ++ FL+F+ ++ IR I F
Sbjct: 706 NGGCTHLCLPS------GQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDT 759
Query: 727 STQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENV 786
D ++P++ S V +D+D++D ++++D+S I + K DGTG+E++ +E+
Sbjct: 760 EDLSDDVIPLADVRS-AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESP 818
Query: 787 ESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYLFFTD 844
LA DW++ LYWTD+ I V D + RTV+ + L+ PR +VV P GY+++TD
Sbjct: 819 AGLAIDWVTNKLYWTDAGTDRIEVAN-TDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTD 877
Query: 845 WFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 904
W KI RA D S +I++ L WPNGLAID+ + RLYW DA IE + DG +
Sbjct: 878 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDG-SK 936
Query: 905 RRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYD 964
R++ Q+ HPFGL ++GE +++TDW+ +I + G + ++ + ++ + +
Sbjct: 937 RKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH 996
Query: 965 VNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRV-CGCPYGMRLASNHLTC 1013
S C NG CSH C PN C CP G+ L S+ TC
Sbjct: 997 RRRPPVSTPC---AMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
Score = 585 bits (1509), Expect = e-166
Identities = 303/740 (40%), Positives = 398/740 (53%), Gaps = 88/740 (11%)
Query: 2818 PDRTCQSGYTKCHNSNI----CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCAS 2873
P+ C + C S + CIP + CDGDNDCGD+SDE+ C TCS +F C +
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG--CILPTCSPLDFHCDN 80
Query: 2874 GRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGD 2933
G+CI + W CD + DC D SDE C R C DEF C G CI S W CDGDNDCGD
Sbjct: 81 GKCIRRSWVCDGDNDCEDDSDEQ-DC--PPRECEEDEFPCQNGYCIRSLWHCDGDNDCGD 137
Query: 2934 MSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRT- 2992
SDE QC + CSD EF C D CI + W CDGD DC DG DE +NC
Sbjct: 138 NSDE----QCDMRKCSDKEFRC-----SDGSCIAEHWYCDGDTDCKDGSDE-ENCPSAVP 187
Query: 2993 ---CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCL-YQTCQQNQFTCQNGRCISKT 3048
C+ EF C YG CI I+ CD +DCGD+SDE C +Q C+ +F C +G CI+
Sbjct: 188 APPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAG 247
Query: 3049 FVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKG 3108
+ CD D DC D SDE C T C +F+C +GRC+ + C+ DDC DNSDE+
Sbjct: 248 WRCDGDADCDDQSDE--RNCTTS--MCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEEN 303
Query: 3109 C----------------------------GINECHDPSIS-------------------- 3120
C G+N+C D S
Sbjct: 304 CENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNG 363
Query: 3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP 3180
GC C + C+C GY+L D TC D++EC E + CSQ C N G++ C C
Sbjct: 364 GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY-CSQGCTNSEGAFQCWCET 422
Query: 3181 GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR 3240
GY PD ++C+ EP L+F+NR +R + Y+L+L L+N +ALDF +
Sbjct: 423 GYELRPDRRSCKALGP-EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRREL 481
Query: 3241 LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN 3300
++W D I R LN +N E +++ L + LAVDWV KLYW D+ + V++L+
Sbjct: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541
Query: 3301 GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII 3360
G HR++L ++ PR +ALHP G +YW DWG+ I MDG+ + +I
Sbjct: 542 GAHRKVLLWQNLE--------KPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIA 593
Query: 3361 STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI 3420
T L WPNG+TIDY +YW DA IE ++L+G HR V LPHPFAIT+FED++
Sbjct: 594 DTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSL 653
Query: 3421 YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC 3480
YWTDW+T+++ NK+ G N++ + N H P DIH HP RQP N CG NNGGC+HLC
Sbjct: 654 YWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLC 713
Query: 3481 LIKPGGKGFTCECPDDFRTL 3500
L P G+ +TC CP FR +
Sbjct: 714 L--PSGQNYTCACPTGFRKI 731
Score = 481 bits (1237), Expect = e-135
Identities = 279/752 (37%), Positives = 382/752 (50%), Gaps = 68/752 (9%)
Query: 3627 SSHCASRTCRPGQFRCANGR-----CIPQAWKCDVDNDCGDHSDEP---IEECMSSAHLC 3678
S CA C F CA CIP W+CD DNDCGDHSDE + C C
Sbjct: 22 SPECA---CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHC 78
Query: 3679 DNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQ 3738
DN +CI + VC+G +DC D+SDEQ C R C +F C+N +CI W
Sbjct: 79 DNG---------KCIRRSWVCDGDNDCEDDSDEQDCPPRECEE-DEFPCQNGYCIRSLWH 128
Query: 3739 CDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT- 3797
CDG NDCGDNSDE+ C R+C++ EFRC + CI W CD DC D SDE +C
Sbjct: 129 CDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVP 187
Query: 3798 ---CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVC 3854
C+ E FQC G C+ CDG DC D SDE+DC + P C++ F C + +C
Sbjct: 188 APPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP----CRSGEFMCDSGLC 243
Query: 3855 IPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTD 3914
I W+CDGD DC D SDE C C + +FRC + RC+ C+G DDC D +D
Sbjct: 244 INAGWRCDGDADCDDQSDERN--CTTSMCTA-EQFRCHSGRCVRLSWRCDGEDDCADNSD 300
Query: 3915 ETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENI 3974
E E+C C ++ C NG CI +C+ +DCGD SDE + RT EN
Sbjct: 301 E--ENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENC 358
Query: 3975 ------CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSY 4028
C Q C Q+ G C+C G+ D +C D+NEC + G C Q C N++G++
Sbjct: 359 NVNNGGCAQKC-QMVRGAVQCTCHTGYRLTE-DGHTCQDVNECAEEGYCSQGCTNSEGAF 416
Query: 4029 ECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVD 4088
+C C G+ DR + C A G P+LL + + IR+ ++ L + E A+D
Sbjct: 417 QCWCETGYELRPDR--RSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALD 474
Query: 4089 YDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIA 4148
+ + + S V I RA + +N+ + V L+ P G+A
Sbjct: 475 FHHRRELVFWSDV---------TLDRILRANL-----NGSNVEEVVSTGLE---SPGGLA 517
Query: 4149 VDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEP 4208
VDWV +YW+D RIEVA LDG +RK L+ +L++P AIA++P G ++WTDWG P
Sbjct: 518 VDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTP 577
Query: 4209 KIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIA 4268
+IE++ M+G R I+ L WP GL+IDY R+YW D K VIE DG+ R+ +
Sbjct: 578 RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR-RMYWVDAKHHVIERANLDGSHRKAVI 636
Query: 4269 KEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYN 4327
+ + +P+++ +FED LYW + NKF +E + + H R
Sbjct: 637 SQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQR-Q 695
Query: 4328 KSVPNLCKQI---CSHLCLLRPGGYSCACPQG 4356
+ N C C+HLCL Y+CACP G
Sbjct: 696 PAGKNRCGDNNGGCTHLCLPSGQNYTCACPTG 727
Score = 390 bits (1003), Expect = e-107
Identities = 216/667 (32%), Positives = 356/667 (53%), Gaps = 26/667 (3%)
Query: 356 GICDQKCESRPGRHLCHCEEGYILERGQYCKAN-DSFGEASIIFSNGRDL--LIGDIHGR 412
G C C + C C G+ C + D F ++F+ D+ + D
Sbjct: 707 GGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKF----LLFARRMDIRRISFDTEDL 762
Query: 413 SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENL 472
S ++ + R AV + + V+WTD + + +G + V++ S+E+P L
Sbjct: 763 SDDVIPLADVRS-AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGL 821
Query: 473 AVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESL 532
A+DWV NK+Y + +RI++ N DGS R LI ENL PR I V+P GY++++DW
Sbjct: 822 AIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW--- 878
Query: 533 SGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRK 592
PK+ERA MD S R+ ++ + L WP G+ +D S+R+YW D+ IE DG +RK
Sbjct: 879 GASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRK 938
Query: 593 TVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYH 652
++ GS +PHPFG++L+ ++++TDW ++ A++ T + + + + V+H
Sbjct: 939 VLI--GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH 996
Query: 653 SLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN-FL 711
R P +T PC NGGC +C+ S GF C C G L +D + C N FL
Sbjct: 997 RRRPPVST-PCAMENGGCSHLCLRSPNPS----GFSCTCPTGINLLSDGKTCSPGMNSFL 1051
Query: 712 IFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKID 771
IF+ ++ IR + + DV+VP++ + I D Q+ +++SD + H I + +D
Sbjct: 1052 IFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLD 1111
Query: 772 GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRS 830
G+ E + ++ + LA D I + +YWTD+ I V L R+ +V Q L++PR+
Sbjct: 1112 GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRA 1171
Query: 831 VVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAY 890
+V++ G++++TDW AK+ R+ DGS +IN LGWPNGL +D A+S+L W DA+
Sbjct: 1172 IVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAH 1231
Query: 891 FDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVI 950
++IE + +G +R L + + HP+GL + ++++TDW+ +I R K G + ++
Sbjct: 1232 TERIEAADLNGANRHTL--VSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILV 1289
Query: 951 RSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNH 1010
RS + ++ +++ D G N C NG CSH C P P+ C CP G++L +
Sbjct: 1290 RSNLPGLMDMQAVDRAQPLGFNKCGSR---NGGCSHLCLPRPSGFS-CACPTGIQLKGDG 1345
Query: 1011 LTCEGDP 1017
TC+ P
Sbjct: 1346 KTCDPSP 1352
Score = 361 bits (927), Expect = 8e-99
Identities = 212/654 (32%), Positives = 348/654 (53%), Gaps = 32/654 (4%)
Query: 356 GICDQKC--ESRPGRHLCHCEEGY-ILERGQYCKAN-DSFGEASIIFSNGRDLLIGDIHG 411
G C C P C C G +L G+ C +SF +IF+ D+ + +
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF----LIFARRIDIRMVSLDI 1066
Query: 412 RSFRILVESQNRGVAVGVAFHYHLQ--RVFWTDTVQNKVFSVDINGLNIQEVLNVSVETP 469
F +V N + +A Q +V+W+D+ +++ +++G ++++ ++T
Sbjct: 1067 PYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTT 1126
Query: 470 ENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDW 529
+ LAVD + K+Y +T NRI++ NLDGS R L+ +NL PR I + +G+++++DW
Sbjct: 1127 DGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186
Query: 530 ESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGI 589
KLER+ MDGS+R L+ LGWP G+T+D S ++ W D+ + IE +G
Sbjct: 1187 GE---NAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGA 1243
Query: 590 QRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVT 649
R T+V S + HP+G++L + +++TDW ++ +A+K T +N + +++L
Sbjct: 1244 NRHTLV---SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNV-ILVRSNLPGLMDM 1299
Query: 650 VYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI-AVQ 708
QP N C NGGC +C+ GF C C G QL D + C + +
Sbjct: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPE 1353
Query: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
+L+FSS+ +IR I S DV VPV + + +D+D+ D ++++D+ +I +
Sbjct: 1354 TYLLFSSRGSIRRISLDTSDHTDVHVPVP-ELNNVISLDYDSVDGKVYYTDVFLDVIRRA 1412
Query: 769 KIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQY-LNN 827
++G+ E + ++ + LA DW+++NLYWTD+ +I RL R+ ++ L+
Sbjct: 1413 DLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472
Query: 828 PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWV 887
PR++ V P GYLF+TDW AKI RA DGS +INT LGWPNGL +D+ R+YWV
Sbjct: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
Query: 888 DAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEM 947
DA+ D+IE + +G R+ L + ++HPF L +++TDW+ +I RV K G
Sbjct: 1533 DAHLDRIESADLNGKLRQVL--VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
Query: 948 TVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCP 1001
+ + + ++ + QTG+NAC NG C+H CF + VC CP
Sbjct: 1591 ETVLANVEGLMDIIVVSPQRQTGTNACGV---NNGGCTHLCFARAS-DFVCACP 1640
Score = 265 bits (676), Expect = 1e-69
Identities = 138/354 (38%), Positives = 205/354 (57%), Gaps = 17/354 (4%)
Query: 3146 DKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSN 3205
D+ + ++C CS C + C C G + DGKTC + + E YL+FS+
Sbjct: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--DPSPETYLLFSS 1360
Query: 3206 RYYLRNLTIDGYFYSLI---LEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKE 3262
R +R +++D ++ + + L+NV++LD+D V+ ++Y+ D VI R LN +N E
Sbjct: 1361 RGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNME 1420
Query: 3263 TIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDN 3322
T+I L + LAVDWV+R LYW D + + S L+G R++L NN+ D
Sbjct: 1421 TVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLI------NNSL--DE 1472
Query: 3323 PRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWA 3382
PR +A+ P+ GYL+W DWGH A I R +DG+ + V+I+T L WPNG+T+DY +YW
Sbjct: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
Query: 3383 DAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
DAHL IE +DL G R + + HPFA+T + IYWTDW T+++++ +KY G N++
Sbjct: 1533 DAHLDRIESADLNGKLRQVLVSH-VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKE 1591
Query: 3443 TLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDD 3496
T++ DI V P RQ +N CG NNGGC+HLC + F C CPD+
Sbjct: 1592 TVLANVEGLMDIIVVSPQRQT-GTNACGVNNGGCTHLCFAR--ASDFVCACPDE 1642
Score = 259 bits (663), Expect = 3e-68
Identities = 132/355 (37%), Positives = 194/355 (54%), Gaps = 17/355 (4%)
Query: 3163 CSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYS-- 3220
C+ C +Y C C G+ R+ C Q+ ++ +L+F+ R +R ++ D S
Sbjct: 709 CTHLCLPSGQNYTCACPTGF-RKISSHACAQS--LDKFLLFARRMDIRRISFDTEDLSDD 765
Query: 3221 -LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
+ L + + VALD+D + +YW D I R + T +E +++ L + LA+DW
Sbjct: 766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
Query: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
V+ KLYW DA D + V++ +G R +L +D PR + + P GY+YW D
Sbjct: 826 VTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLD--------RPRDIVVEPMGGYMYWTD 877
Query: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
WG I R GMD + + VIIS+ L WPNG+ IDY + LYWADA + IE++ L+G R
Sbjct: 878 WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Query: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
+ LPHPF +T++ + IYWTDW T++++ ++ G +R+TL DIHV+H
Sbjct: 938 KVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH- 996
Query: 3460 YRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSS 3514
R+P VS PC NGGCSHLCL P GF+C CP LS C P +S
Sbjct: 997 RRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINL--LSDGKTCSPGMNS 1049
Score = 258 bits (658), Expect = 1e-67
Identities = 139/338 (41%), Positives = 170/338 (50%), Gaps = 21/338 (6%)
Query: 3502 LSGSTYCMPMCSSTQFLCANNE----KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQ 3557
L+ S C C + F CA + CIP W+CDG DC D SDE C C
Sbjct: 19 LASSPECA--CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG-CILPTCSPLD 75
Query: 3558 FQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFN 3617
F C +G C +C+ +C D SDE C C+ +E+ C N CI W CD N
Sbjct: 76 FHCDNGKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQNGYCIRSLWHCDGDN 133
Query: 3618 DCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSS--A 3675
DC DNSDE C R C +FRC++G CI + W CD D DC D SDE E C S+ A
Sbjct: 134 DCGDNSDEQ---CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE--ENCPSAVPA 188
Query: 3676 HLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPL 3735
C N EF C RCI C+G DDC D SDE C G+F C + CI
Sbjct: 189 PPC-NLEEFQCAYG-RCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
Query: 3736 RWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE- 3794
W+CDG DC D SDE NC CT +FRC + +C+ W CD +DC DNSDE +CE
Sbjct: 247 GWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCEN 306
Query: 3795 --MRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
C + F C +G C+ C+G DC D SDE+
Sbjct: 307 TGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDES 344
Score = 230 bits (586), Expect = 3e-59
Identities = 130/360 (36%), Positives = 195/360 (54%), Gaps = 28/360 (7%)
Query: 3163 CSQKC---ENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID-GYF 3218
CS C N G + C C G DGKTC N +LIF+ R +R +++D YF
Sbjct: 1013 CSHLCLRSPNPSG-FSCTCPTGINLLSDGKTCSPGMN--SFLIFARRIDIRMVSLDIPYF 1069
Query: 3219 YSLILE---GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESL 3275
+++ + N +A+ D E ++YW D+ I R L+ + E II L + L
Sbjct: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGL 1129
Query: 3276 AVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYL 3335
AVD + RK+YW D + + V +L+G R++L +D+ PR + L+ + G++
Sbjct: 1130 AVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDS--------PRAIVLYHEMGFM 1181
Query: 3336 YWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLE 3395
YW DWG A + R GMDG++++V+I+ L WPNG+T+D + L WADAH IE +DL
Sbjct: 1182 YWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLN 1241
Query: 3396 GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIH 3455
G +RHT+ + HP+ +T+ + IYWTDW TR++ + +K GSN + + D+
Sbjct: 1242 GANRHTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQ 1300
Query: 3456 VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECP------DDFRTLQLSGSTYCM 3509
QP+ N CG+ NGGCSHLCL +P GF+C CP D +T S TY +
Sbjct: 1301 AV-DRAQPLGFNKCGSRNGGCSHLCLPRP--SGFSCACPTGIQLKGDGKTCDPSPETYLL 1357
Score = 182 bits (461), Expect = 9e-45
Identities = 103/295 (34%), Positives = 139/295 (47%), Gaps = 23/295 (7%)
Query: 1013 CEGD-PTNEPPTEQCGLFS-----FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTL--N 1064
C+GD + EQC + F C +G C+ ++ CDG DC D SDE+ C +
Sbjct: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPA 188
Query: 1065 NTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISK 1124
C+ F C +G CI + CD +DC D SDE +C +H P C ++ CD+ CI+
Sbjct: 189 PPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMCDSGLCINA 246
Query: 1125 NWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC- 1183
W CD D DC D SDE+NC +T C QF C + RC+ LS+ CDG+ DC D SDE C
Sbjct: 247 GWRCDGDADCDDQSDERNC-TTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCE 305
Query: 1184 ---VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEA---GC-PTRPPGMCHSDEFQ 1236
C QF C +G +CIG C+GV DC DNSDE+ C P C+ +
Sbjct: 306 NTGSPQCALDQFLCWNG-RCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGG 364
Query: 1237 CQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYF---HCDNGNCIHRAW 1288
C + + +C H D H C + C N + W
Sbjct: 365 CAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCW 419
Score = 180 bits (456), Expect = 3e-44
Identities = 118/364 (32%), Positives = 176/364 (48%), Gaps = 28/364 (7%)
Query: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
N C + G C C + +Y C C GF +S A+ LL + IR+
Sbjct: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSH----ACAQSLDKFLLFARRMDIRRI 755
Query: 4068 NLSSERFSE-YLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESG 4126
+ +E S+ + + AV DWD +D VY+T + I RA ++
Sbjct: 756 SFDTEDLSDDVIPLADVRSAVALDWDSRD---DHVYWTDVSTDT----ISRA---KWDGT 805
Query: 4127 RNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQ 4186
+V + L+ P G+A+DWV +YW+D RIEVA DG R LI +LD+
Sbjct: 806 GQEVVVDTSLE-----SPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 860
Query: 4187 PAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYW 4246
P I V P G M+WTDWG PKIE A M+ R +++ +L WP GL+IDY + R+YW
Sbjct: 861 PRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY-GSQRLYW 919
Query: 4247 SDFKEDVIETIKYDGTDRRV-IAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKK 4305
+D IE DG+ R+V I + +P+ L ++ +++YW + + ++ G
Sbjct: 920 ADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRL-TGLD 978
Query: 4306 EKTLVVN-PWLTQVRIFHQLRYNKSVPNLCKQ-ICSHLCLL--RPGGYSCACPQGSSFIE 4361
+TL N L + +FH+ R S P + CSHLCL P G+SC CP G + +
Sbjct: 979 RETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLS 1038
Query: 4362 GSTT 4365
T
Sbjct: 1039 DGKT 1042
Score = 179 bits (454), Expect = 6e-44
Identities = 116/357 (32%), Positives = 173/357 (48%), Gaps = 22/357 (6%)
Query: 4001 DRTSCLDINEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLP 4059
DR L N+C + G C C + C C G D GK C + LL
Sbjct: 1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGD--GKTCDPSPET-YLLFS 1359
Query: 4060 DNVRIRKYNL-SSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRA 4118
IR+ +L +S+ ++ E + D+D D VYYT I+RA
Sbjct: 1360 SRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVD---GKVYYT----DVFLDVIRRA 1412
Query: 4119 YIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKW 4178
+ +N+ + LK DG+AVDWV R++YW+D IE ++LDG RK
Sbjct: 1413 -----DLNGSNMETVIGRGLKTT---DGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKV 1464
Query: 4179 LISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 4238
LI+ LD+P AIAV P+ G +FWTDWG KIE A ++G +R +L+ DLGWP GL++DY
Sbjct: 1465 LINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Query: 4239 LNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQN 4298
+ RIYW D D IE+ +G R+V+ +P++L + +YW + + + +
Sbjct: 1525 -DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVD 1583
Query: 4299 KFGQGKKEKTLV-VNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACP 4354
K+ KE L V + + + Q + + + C+HLC R + CACP
Sbjct: 1584 KYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACP 1640
Score = 170 bits (431), Expect = 3e-41
Identities = 112/366 (30%), Positives = 176/366 (48%), Gaps = 31/366 (8%)
Query: 4015 GTCPQHCRNTKG--SYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSE 4072
G C C + + C C G +SD GK C+ G + L+ + IR +L
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSD--GKTCSP-GMNSFLIFARRIDIRMVSLDIP 1067
Query: 4073 RFSEYLQDEEYIQ--AVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNL 4130
F++ + + DP++ VY++ S I RA +
Sbjct: 1068 YFADVVVPINITMKNTIAIGVDPQE---GKVYWS----DSTLHRISRANLDGS------- 1113
Query: 4131 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAI 4190
Q D+ + DG+AVD +GR +YW+D RIEV LDG RK L+ +LD P AI
Sbjct: 1114 -QHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAI 1172
Query: 4191 AVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFK 4250
+ ++G M+WTDWG+ K+E + M+G DR +L+ +LGWP GL++D ++ ++ W+D
Sbjct: 1173 VLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASS-QLLWADAH 1231
Query: 4251 EDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
+ IE +G +R + +PY L + + +YW + + + +K G G +
Sbjct: 1232 TERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK-GTGSNVILVR 1290
Query: 4311 VN-PWLTQVRIFHQ---LRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTE 4366
N P L ++ + L +NK CSHLCL RP G+SCACP G ++G
Sbjct: 1291 SNLPGLMDMQAVDRAQPLGFNKCGSR--NGGCSHLCLPRPSGFSCACPTGIQ-LKGDGKT 1347
Query: 4367 CDAAIE 4372
CD + E
Sbjct: 1348 CDPSPE 1353
Score = 169 bits (427), Expect = 8e-41
Identities = 105/292 (35%), Positives = 136/292 (46%), Gaps = 23/292 (7%)
Query: 2682 NWYLANNRKHCIVDNG-----------ERCGASSFTCSNGRCISEEWKCDNDNDCGDGSD 2730
N Y + HC DN +C F CS+G CI+E W CD D DC DGSD
Sbjct: 119 NGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
Query: 2731 EMESVCALHT--CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC 2788
E A+ C+ F CA GRC+ Y CD +DCGD SDE+ C + EFMC
Sbjct: 179 EENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC 238
Query: 2789 NNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDC 2848
++ CI + C+G +C D SDE+NC C + +CH S C+ + CDG++DC
Sbjct: 239 DSGLCINAGWRCDGDADCDDQ--SDERNCTTSMCTAEQFRCH-SGRCVRLSWRCDGEDDC 295
Query: 2849 GDNSD-ENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCL 2907
DNSD EN + C+ +F C +GRCI Q C+ DC D SDE RT
Sbjct: 296 ADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTG- 354
Query: 2908 ADEFKCDGGRCIPSEWICDGDNDC----GDMSDEDKRHQCQNQNCSDSEFLC 2955
+ + G C + G C G ED H CQ+ N E C
Sbjct: 355 EENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTED-GHTCQDVNECAEEGYC 405
Score = 111 bits (278), Expect = 1e-23
Identities = 72/223 (32%), Positives = 101/223 (45%), Gaps = 39/223 (17%)
Query: 183 CLHNEFSC-----GNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQ 237
C + F+C G CIP + CD DNDC D SDE C PTC F C +G+CI +
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR 86
Query: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
+WVCDG++DC+D+ DE C +C E+ C ++G CI CDG DC D
Sbjct: 87 SWVCDGDNDCEDDSDEQDCPP-----RECEEDEFPC-QNGYCIRSLWHCDGDNDCGDNSD 140
Query: 298 ENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGI 357
E C M CS + +++C + G+C Y C DC+ G
Sbjct: 141 EQ-------CDMRKCS--DKEFRCSD----GSCIAEHWY---------CDGDTDCKD-GS 177
Query: 358 CDQKCESRPGRHLCHCEE-----GYILERGQYCKANDSFGEAS 395
++ C S C+ EE G + +C +D G+ S
Sbjct: 178 DEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWS 220
Score = 76.3 bits (186), Expect = 7e-13
Identities = 61/201 (30%), Positives = 85/201 (42%), Gaps = 27/201 (13%)
Query: 3468 PCGTNNGGC-SHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCI 3526
PC + C S LC+ G+ C+ D Q MC++ QF C ++ +C+
Sbjct: 230 PCRSGEFMCDSGLCI----NAGWRCDGDADCDD-QSDERNCTTSMCTAEQFRC-HSGRCV 283
Query: 3527 PIWWKCDGQKDCSDGSDELAL----CPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGS 3582
+ W+CDG+ DC+D SDE PQ C L QF C +G C + LCN +C D S
Sbjct: 284 RLSWRCDGEDDCADNSDEENCENTGSPQ--CALDQFLCWNGRCIGQRKLCNGVNDCGDNS 341
Query: 3583 DED-----RLLCENHHCDSNEWQCANK-RCIPESWQCDTFNDCEDNSD----EDSSHCAS 3632
DE R +C+ N CA K + + + QC D +D + CA
Sbjct: 342 DESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAE 401
Query: 3633 R-TCRPGQFRCANGRCIPQAW 3652
C G C N Q W
Sbjct: 402 EGYCSQG---CTNSEGAFQCW 419
Score = 47.4 bits (111), Expect = 3e-04
Identities = 24/80 (30%), Positives = 33/80 (41%)
Query: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESV 2735
+C E + ++ ++C +C F C NGRCI + C+ NDCGD SDE
Sbjct: 288 RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
Query: 2736 CALHTCSPTAFTCANGRCVQ 2755
NG C Q
Sbjct: 348 NCRPRTGEENCNVNNGGCAQ 367
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 686 bits (1771), Expect = 0.0
Identities = 452/1401 (32%), Positives = 727/1401 (51%), Gaps = 82/1401 (5%)
Query: 1437 LLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQN 1496
LLL A++ + T+ N +V AVDF G I+WSD ++ N
Sbjct: 22 LLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFN 81
Query: 1497 GTDR-RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPR 1555
T+ + V S ++ + +A DW+G LYWTD IEVS +DGS R VL + L PR
Sbjct: 82 KTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141
Query: 1556 GLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFM 1615
+ALDP + ++W+DWG P+IERA MDGS R +I+ +I+WP GLT+DY + LY+
Sbjct: 142 AIALDP--SSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 199
Query: 1616 DSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGN 1675
D+ L+++ + +G +R+ V+ L HP+ALTLFED +YWTD +T ++ NK+ G
Sbjct: 200 DAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWSTHSILACNKYTGEG 257
Query: 1676 QSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSL 1733
+ +I P+ I A +QPN+ NPC CSHLCL+S P FY C CP+G L
Sbjct: 258 LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKP-FYQCACPTGVKL 316
Query: 1734 SPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIY 1793
+ C L+ R+ + ISL+ D ++ + I++ + +++D E YIY
Sbjct: 317 LENGKTCKDGATELLLLARRTDLRRISLDTP-DFTDIVLQLEDIRHAIAIDYDPVEGYIY 375
Query: 1794 WVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHG 1852
W ++ I R DG+ + + P +A+DW++RNLY T+ T IEV L+G
Sbjct: 376 WTDDEVRAIRRSFIDGSGSQFVVTAQIAHPD-GIAVDWVARNLYWTDTGTDRIEVTRLNG 434
Query: 1853 DIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKT 1912
+ RK LI+ D + P I +DP G +YW+D G +P KI A +DG+
Sbjct: 435 TM--RKILISED-----LEEPRAIVLDPMVGYMYWTDWGE---IP-KIERAALDGSDRVV 483
Query: 1913 LFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH-QLSHPWGIAVHDS 1971
L +L + LD +E K+YW IE N DGT R +LV ++ H +G +
Sbjct: 484 LVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD 543
Query: 1972 FLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQ 2031
++Y+TD Q IERV K + ++++ D +P+L GL+ + SN C+ C
Sbjct: 544 YVYWTDWQRRSIERVHKRSAEREVII-DQLPDLMGLKATNVHRVI-GSNPCAEENGGCSH 601
Query: 2032 ICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVA 2091
+CL P GL CAC GF+L D ++C +F++ S + IR SLE ++++ +P+
Sbjct: 602 LCLYRPQGL-RCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLE-TNNNNVAIPLT 659
Query: 2092 GQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIA 2151
G + A +D DV+ IYW D S I R +GS+L ++V G+ + G+A
Sbjct: 660 GV-KEASALDFDVTDNRIYWTDISL-----KTISRAFMNGSALEHVVEFGL--DYPEGMA 711
Query: 2152 VDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQ 2211
VDW+ NLY+ + + IEV +++ +R+VL+ +D PR + +DP +++W ++G
Sbjct: 712 VDWLGKNLYWADTGTNR--IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGG 769
Query: 2212 RPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVI 2271
+PKI+R+ +D + RT LV + GL +D + +YW D ++I + G N EVI
Sbjct: 770 KPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI 828
Query: 2272 RYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDK 2331
P P+G+T +++ I W D + + I +A+K + + T+I+ +++++ D+ +F
Sbjct: 829 --ADDLPHPFGLTQYQDYIYWTDWSRRSIERANK--TSGQNRTIIQGHLDYVMDILVF-- 882
Query: 2332 QVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDC-AFGTLQSDGKNCAISTENFL 2390
S + N C +NG CSHLC A+P + C C A +L +D + C+ T FL
Sbjct: 883 ----HSSRQSGWNECASSNGHCSHLCLAVP-VGGFVCGCPAHYSLNADNRTCSAPT-TFL 936
Query: 2391 IFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYAT 2450
+F+ +++ + +D + I+ R V ++DYD + ++Y+ + + + +
Sbjct: 937 LFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQ--- 993
Query: 2451 LSSGIHTPTVIASGIGTAD------GIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIA 2504
G TV+ S + + + ++ D +R IY++ +IN DG + V+
Sbjct: 994 -EDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVL 1052
Query: 2505 R--VPKPRAIVLDPCQGYLYWADWDTHA-KIERATLGGNFRVPIVNSSLVMPSGLTLDYE 2561
+ +PRA+V++P +GY+Y+ + + KIERA L G R + S L P L LD
Sbjct: 1053 KGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSR 1112
Query: 2562 EDLLYWVDASLQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANK 2620
L+W D+ L+RIE S L+G +R V+ ++ + GLT++ ++YW D Q I + +
Sbjct: 1113 LGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM 1172
Query: 2621 YDGSGQIAMTTNLLSQPRGINTVVK-NQKQQCNNPCEQFNGGCSHIC-APGPNGAECQCP 2678
G+ + ++Q I+ V + N ++ +PC Q NGGCSHIC G C CP
Sbjct: 1173 TGREGRTKVQAR-IAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCP 1231
Query: 2679 HEGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDNDNDCGDGSDEMESVC 2736
+L + C FTC G CI W+CD +C D SDE+ C
Sbjct: 1232 ----MHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN--C 1285
Query: 2737 ALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPR 2796
+ CS + F CA+G+C+ + RC+ +C D SDE C +F C N +CI +
Sbjct: 1286 PV--CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGK 1341
Query: 2797 EFICNGVDNCHDNNTSDEKNC 2817
C+ +C D SDE +C
Sbjct: 1342 HKKCDHNVDCSDK--SDELDC 1360
Score = 488 bits (1257), Expect = e-137
Identities = 310/983 (31%), Positives = 512/983 (52%), Gaps = 53/983 (5%)
Query: 1398 GSCSQHCYN--MRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQV 1455
G CS C ++ ++C+C TG L +G+TCK A+E LLL + + I+ T
Sbjct: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLD-TPDF 349
Query: 1456 HNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIA 1515
+I +E+ + +A+D+D + G I+W+D +F +G+ + V + I + IA
Sbjct: 350 TDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIA 409
Query: 1516 IDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH 1575
+DWV RNLYWTD + IEV++++G+ R +LIS++L PR + LDP + ++W+DWG
Sbjct: 410 VDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVG--YMYWTDWGE 467
Query: 1576 HPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQV 1635
P+IERA++DGS R V+V + WP GL +DY +Y+ D+ D ++ + +G RR +
Sbjct: 468 IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL 527
Query: 1636 IASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPS 1695
+ I H + TL D VYWTD R + R +K + V++ + +G+ A +
Sbjct: 528 VEDK--IPHIFGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVH 584
Query: 1696 KQPNSVNPCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
+ S NPCA CSHLCL QG C CP G+ L D+ C+ + FL+ R+
Sbjct: 585 RVIGS-NPCAEENGGCSHLCLYRPQG---LRCACPIGFELISDMKTCI-VPEAFLLFSRR 639
Query: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRT 1812
I ISL E +N+ +P+ G++ ++FD + IYW + + I R +G+
Sbjct: 640 ADIRRISL--ETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALE 697
Query: 1813 VFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGF 1872
+ P +A+DW+ +NLY + T IEV L G ++R+ L+ D +
Sbjct: 698 HVVEFGLDYPE-GMAVDWLGKNLYWADTGTNRIEVSKLDG--QHRQVLVWKD-----LDS 749
Query: 1873 PIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQK 1932
P + +DPA G +YW++ G G P KI A MDG S +T N+ +T+D +++
Sbjct: 750 PRALALDPAEGFMYWTEWG---GKP-KIDRAAMDG-SERTTLVPNVGRANGLTIDYAKRR 804
Query: 1933 LYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGA 1992
LYW +IE N+ G +R ++ L HP+G+ + ++Y+TD IER +K +G
Sbjct: 805 LYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQ 864
Query: 1993 NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLN 2052
N+ +++ ++ + + V+H + N C+++ C +CL VP G F C C + LN
Sbjct: 865 NRTIIQGHLDYVMDILVFH-SSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLN 923
Query: 2053 PDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWC 2112
DNR+CS +F++ S SAI ++ + ++P+ RN +D D +YW
Sbjct: 924 ADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSL-RNVRAIDYDPLDKQLYWI 982
Query: 2113 DFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVR----GIAVDWVAGNLYFTNAFVSE 2168
D + N IR+ + DGS +V + + +++D + +Y+T +
Sbjct: 983 D-----SRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT--CEAT 1035
Query: 2169 TLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTV 2227
+I V R++ V+LK D PR +VV+P+ Y+++ + +R PKIER+ LD T R V
Sbjct: 1036 NVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREV 1095
Query: 2228 LVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFE 2287
L G+ P LA+D G ++W D L I ++G N ++ S P G+TVFE
Sbjct: 1096 LFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN-RIVLEDSNILQPVGLTVFE 1154
Query: 2288 NSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCL 2347
N + W+D+ + I + + E T ++ I L D+ V+ + E +PC
Sbjct: 1155 NWLYWIDKQQQMIEKI--DMTGREGRTKVQARIAQLSDI----HAVKELNLQEYRQHPCA 1208
Query: 2348 ENNGGCSHLCFALPGLHTPKCDC 2370
++NGGCSH+C + G T +C C
Sbjct: 1209 QDNGGCSHICL-VKGDGTTRCSC 1230
Score = 383 bits (983), Expect = e-105
Identities = 210/623 (33%), Positives = 351/623 (56%), Gaps = 23/623 (3%)
Query: 396 IIFSNGRDL-LIGDIHGR-SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDI 453
++++N RDL L+ +G+ + I+V AV F + L ++W+D + + +
Sbjct: 23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL--IYWSDVSEEAIKRTEF 80
Query: 454 NGL-NIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHP 512
N ++Q V+ + +P+ LA DW+ K+Y +++ NRI++ NLDGS R L + L P
Sbjct: 81 NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
Query: 513 RGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVY 572
R IA+DP+ G+++++DW + PK+ERA MDGS+R ++ +++ WP G+TLD +++Y
Sbjct: 141 RAIALDPSSGFMYWTDWGEV---PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLY 197
Query: 573 WVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632
W D++ ++I DG R+ VV G +PHPF ++LFE +++TDW+ ++L NK+T
Sbjct: 198 WADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTG 255
Query: 633 TNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCT 692
+ + P + + RQP ATNPC +NGGC +C++S ++C C
Sbjct: 256 EGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPF----YQCACP 311
Query: 693 FGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQ 751
G +L + + C L+ + + +R I D+++ + + + ID+D
Sbjct: 312 TGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLE-DIRHAIAIDYDPV 370
Query: 752 DSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVM 811
+ I+++D I + IDG+G + + ++ + + +A DW+++NLYWTD+ I V
Sbjct: 371 EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVT 430
Query: 812 RLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870
RL R+ ++ + L PR++V+ P GY+++TDW KI RA DGS + ++NT+LG
Sbjct: 431 RLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLG 490
Query: 871 WPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTD 930
WPNGLA+D+ ++YW DA DKIE DG RR L +++ H FG + G+++++TD
Sbjct: 491 WPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTLLGDYVYWTD 549
Query: 931 WRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFP 990
W+ +I RV K E VI + ++ LK+ +V+ GSN C NG CSH C
Sbjct: 550 WQRRSIERVHKR-SAEREVIIDQLPDLMGLKATNVHRVIGSNPC---AEENGGCSHLCLY 605
Query: 991 VPNFQRVCGCPYGMRLASNHLTC 1013
P R C CP G L S+ TC
Sbjct: 606 RPQGLR-CACPIGFELISDMKTC 627
Score = 381 bits (978), Expect = e-104
Identities = 254/822 (30%), Positives = 404/822 (49%), Gaps = 68/822 (8%)
Query: 356 GICDQKCESRPGRHLCHCEEGY-ILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSF 414
G C C RP C C G+ ++ + C ++F ++FS D+
Sbjct: 597 GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAF----LLFSRRADIR--------- 643
Query: 415 RILVESQNRGVAVGVA---------FHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVS 465
RI +E+ N VA+ + F R++WTD + +NG ++ V+
Sbjct: 644 RISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFG 703
Query: 466 VETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLF 525
++ PE +AVDW+ +Y +T NRI++ LDG +R L+ ++L PR +A+DP G+++
Sbjct: 704 LDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMY 763
Query: 526 FSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVT 585
+++W G+PK++RA MDGS R LV +G G+T+D +R+YW D + IE+
Sbjct: 764 WTEW---GGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSN 819
Query: 586 YDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRP 645
G+ R+ + +PHPFG++ ++ +++TDW++ ++ +ANK + N +
Sbjct: 820 MLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYV 876
Query: 646 YGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705
+ V+HS RQ N C +NG C +C+ GF C C + L+ D R C
Sbjct: 877 MDILVFHSSRQS-GWNECASSNGHCSHLCLAVPVG-----GFVCGCPAHYSLNADNRTCS 930
Query: 706 AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
A FL+FS + AI + D+++P+ + ID+D D +++ D ++MI
Sbjct: 931 APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRN-VRAIDYDPLDKQLYWIDSRQNMI 989
Query: 766 FKQKIDGTGREILAANRV--ENVE----SLAFDWISKNLYWTDSHYKSISVMRLADKTRR 819
K + DG+ + + V +N+E L+ D S+ +YWT I+V RL ++
Sbjct: 990 RKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG 1049
Query: 820 TVVQ-YLNNPRSVVVHPFAGYLFFTD-WFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAI 877
V++ + PR+VVV+P GY++FT+ R KI RA DG+ + + L P LA+
Sbjct: 1050 VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
Query: 878 DWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAII 937
D +L+W D+ +IE S G +R L + P GL +F L++ D + I
Sbjct: 1110 DSRLGKLFWADSDLRRIESSDLSGANRIVL-EDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
Query: 938 RVRKADGGEMTVIRSGIAYILHLKSY-DVNIQT-GSNACNQPTHPNGDCSHFCFPVPNFQ 995
++ T +++ IA + + + ++N+Q + C Q NG CSH C +
Sbjct: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQ---DNGGCSHICLVKGDGT 1225
Query: 996 RVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGR--CVPNYYLCDGVDDCHD 1053
C CP + L + L+C EPPT C F C G C+P + CDG +C D
Sbjct: 1226 TRCSCPMHLVLLQDELSC-----GEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECED 1278
Query: 1054 NSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQ 1113
+SDE C CS S F C G+CI RC+ +C D SDE NC CL Q
Sbjct: 1279 HSDELNC----PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC----EVLCLIDQ 1330
Query: 1114 YTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFN 1155
+ C N QCI K+ CD + DC D SDE +C TE P N
Sbjct: 1331 FRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATN 1372
Score = 327 bits (838), Expect = 2e-88
Identities = 227/735 (30%), Positives = 365/735 (49%), Gaps = 90/735 (12%)
Query: 1342 TDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCS 1401
T+ + N C++ NGGC+H C+ P G +C CP+GF L +D KTC + E +L
Sbjct: 581 TNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC-IVPEAFLL---- 635
Query: 1402 QHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL 1461
++ R R + + + N +A +T
Sbjct: 636 ---FSRRADIR------------------------RISLETNNNNVAIPLTG-------- 660
Query: 1462 VENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGR 1521
V+ S A+DFD RI+W+D + AF NG+ V + + E +A+DW+G+
Sbjct: 661 VKEAS---ALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGK 717
Query: 1522 NLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIER 1581
NLYW D IEVSK+DG HR VL+ K+L +PR LALDP E ++W++WG P+I+R
Sbjct: 718 NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPA--EGFMYWTEWGGKPKIDR 775
Query: 1582 ASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLI 1641
A+MDGS RT +V + + GLTIDY R LY+ D + ++ + G + R+VIA DL
Sbjct: 776 AAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIADDL- 832
Query: 1642 IRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSV 1701
HP+ LT ++D +YWTD + R + RANK G N++++ ++ + + I+ H S+Q +
Sbjct: 833 -PHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGW 890
Query: 1702 NPCAFS--RCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGI 1759
N CA S CSHLCL G + C CP+ +SL+ D C FL+ ++ I +
Sbjct: 891 NECASSNGHCSHLCLAVPVGG--FVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947
Query: 1760 SLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASIS 1818
++ E +S D ++PI ++N +++D ++ +YW+++ I + + DG+ F +
Sbjct: 948 VID-EQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQG--FTVVV 1004
Query: 1819 MVGPSMN-------LALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVG 1871
PS N L++D SR +Y T T I V L DG ++GV
Sbjct: 1005 SSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRL-------------DGRSVGVV 1051
Query: 1872 F------PIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVT 1925
P + V+P +G +Y+++ S KI A +DGT + LF L +
Sbjct: 1052 LKGEQDRPRAVVVNPEKGYMYFTNLQERS---PKIERAALDGTEREVLFFSGLSKPIALA 1108
Query: 1926 LDIEEQKLYWAVTGRGVIERGNVDGTDRMILV-HQLSHPWGIAVHDSFLYYTDEQYEVIE 1984
LD KL+WA + IE ++ G +R++L + P G+ V +++LY+ D+Q ++IE
Sbjct: 1109 LDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
Query: 1985 RVDKATGANKIVLRDNVPNLRGLQVYHRRNAAE-SSNGCSNNMNACQQICLPVPGGLFSC 2043
++D + ++ + L + N E + C+ + C ICL G C
Sbjct: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRC 1228
Query: 2044 ACATGFKLNPDNRSC 2058
+C L D SC
Sbjct: 1229 SCPMHLVLLQDELSC 1243
Score = 256 bits (655), Expect = 3e-67
Identities = 122/306 (39%), Positives = 184/306 (60%), Gaps = 11/306 (3%)
Query: 3199 PYLIFSNRYYLR--NLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL 3256
P L+++NR LR + T ++++ GL++ A+DF +YW D + I+R
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
Query: 3257 NKTNK-ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDAN 3315
NKT + ++ L + + LA DW+ KLYW D+ + + VS+L+G R++L +D
Sbjct: 81 NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELD-- 138
Query: 3316 NTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYT 3375
PR +AL P G++YW DWG I R GMDG+++ +II++++ WPNG+T+DY
Sbjct: 139 ------QPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYE 192
Query: 3376 NDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNK 3435
LYWADA L +I S+L+G +R V G+LPHPFA+T+FED +YWTDW+T ++ NK
Sbjct: 193 EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNK 252
Query: 3436 YDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPD 3495
Y G + + + P DIH + RQP +NPCG +NGGCSHLCL+ P + C CP
Sbjct: 253 YTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPT 312
Query: 3496 DFRTLQ 3501
+ L+
Sbjct: 313 GVKLLE 318
Score = 248 bits (633), Expect = 1e-64
Identities = 160/486 (32%), Positives = 241/486 (49%), Gaps = 33/486 (6%)
Query: 3154 DECTEMPFVCSQKCENV-IGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL 3212
+EC CS C V +G ++C C Y D +TC + +L+FS + + +
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTT---FLLFSQKSAINRM 947
Query: 3213 TIDGYFYS---LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRL 3269
ID L + L NV A+D+D ++K+LYWID+++ +I + + + T++ +
Sbjct: 948 VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
Query: 3270 PAAE------SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNP 3323
P+ L++D SR +YW + + V+ L+G ++ + D P
Sbjct: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQD--------RP 1059
Query: 3324 RGLALHPQYGYLYWADWGHRA-YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWA 3382
R + ++P+ GY+Y+ + R+ I R +DGT + V+ + L P + +D L+WA
Sbjct: 1060 RAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWA 1119
Query: 3383 DAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
D+ L IE SDL G +R + D + P +T+FE+ +YW D + +EK + R
Sbjct: 1120 DSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRT 1179
Query: 3443 TLVNTTHRPFDIHVYHPYR-QPIVSNPCGTNNGGCSHLCLIKPGGKGFT-CECPDDFRTL 3500
+ + DIH Q +PC +NGGCSH+CL+K G G T C CP L
Sbjct: 1180 KVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVK--GDGTTRCSCPMHLVLL 1237
Query: 3501 QLSGSTYCMPMCSSTQFLCANNE-KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQ 3559
Q S P CS QF C E CIP+ W+CDG +C D SDEL CP C QFQ
Sbjct: 1238 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN-CP--VCSESQFQ 1294
Query: 3560 CSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
C+ G C CN NC D SDE CE C ++++CAN +CI + +CD DC
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKN--CE-VLCLIDQFRCANGQCIGKHKKCDHNVDC 1351
Query: 3620 EDNSDE 3625
D SDE
Sbjct: 1352 SDKSDE 1357
Score = 229 bits (583), Expect = 6e-59
Identities = 138/419 (32%), Positives = 204/419 (48%), Gaps = 64/419 (15%)
Query: 3110 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 3169
G N C + + GC H C C+C G++L+SD +TC+ +P
Sbjct: 588 GSNPCAEEN-GGCSHLCLYRPQGLRCACPIGFELISDMKTCI-------VP--------- 630
Query: 3170 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID--GYFYSLILEGLD 3227
E +L+FS R +R ++++ ++ L G+
Sbjct: 631 ----------------------------EAFLLFSRRADIRRISLETNNNNVAIPLTGVK 662
Query: 3228 NVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWL 3287
ALDFD + R+YW D + I R F+N + E ++ L E +AVDW+ + LYW
Sbjct: 663 EASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
Query: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347
D + + VS L+G HR++L + D+PR LAL P G++YW +WG + I
Sbjct: 723 DTGTNRIEVSKLDGQHRQVLVWKDL--------DSPRALALDPAEGFMYWTEWGGKPKID 774
Query: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGAL 3407
R MDG+ ++ ++ + NG+TIDY LYW D IE S++ G +R + D L
Sbjct: 775 RAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD-L 832
Query: 3408 PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSN 3467
PHPF +T ++D IYWTDW+ R++E+ NK G NR + DI V+H RQ N
Sbjct: 833 PHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQS-GWN 891
Query: 3468 PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCI 3526
C ++NG CSHLCL P G GF C CP + +L T P T FL + + I
Sbjct: 892 ECASSNGHCSHLCLAVPVG-GFVCGCPAHY-SLNADNRTCSAP----TTFLLFSQKSAI 944
Score = 224 bits (572), Expect = 1e-57
Identities = 115/343 (33%), Positives = 184/343 (53%), Gaps = 19/343 (5%)
Query: 3163 CSQKC--ENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYS 3220
CS C V Y C C G +GKTC+ + L+ + R LR +++D ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGAT--ELLLLARRTDLRRISLDTPDFT 350
Query: 3221 ---LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAV 3277
L LE + + +A+D+D VE +YW D + + I R F++ + + ++ ++ + +AV
Sbjct: 351 DIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
Query: 3278 DWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYW 3337
DWV+R LYW D D + V+ LNG R++L ++ PR + L P GY+YW
Sbjct: 411 DWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLE--------EPRAIVLDPMVGYMYW 462
Query: 3338 ADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGH 3397
DWG I R +DG+++ V+++T L WPNG+ +DY +YW DA IE + +G
Sbjct: 463 TDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGT 522
Query: 3398 HRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVY 3457
R + + +PH F T+ D +YWTDW R++E+ +K + R+ +++ +
Sbjct: 523 GRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKAT 581
Query: 3458 HPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
+ +R I SNPC NGGCSHLCL +P +G C CP F +
Sbjct: 582 NVHR-VIGSNPCAEENGGCSHLCLYRP--QGLRCACPIGFELI 621
Score = 207 bits (528), Expect = 1e-52
Identities = 131/358 (36%), Positives = 195/358 (54%), Gaps = 29/358 (8%)
Query: 4015 GTCPQHCRNT--KGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSE 4072
G C C + K Y+C C G + + GK C +G++ LLLL +R+ +L +
Sbjct: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLEN--GKTCK-DGATELLLLARRTDLRRISLDTP 347
Query: 4073 RFSEY-LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLV 4131
F++ LQ E+ A+ D+DP + +Y+T AI+R++I SG +V
Sbjct: 348 DFTDIVLQLEDIRHAIAIDYDPVE---GYIYWT----DDEVRAIRRSFIDG--SGSQFVV 398
Query: 4132 QEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIA 4191
+ PDGIAVDWV R++YW+D RIEV +L+G RK LIS DL++P AI
Sbjct: 399 TA------QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIV 452
Query: 4192 VNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE 4251
++P +G M+WTDWG+ PKIE A ++G DR +LV LGWP GL++DY + +IYW D K
Sbjct: 453 LDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY-DEGKIYWGDAKT 511
Query: 4252 DVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
D IE + DGT RRV+ ++ + + + + D +YW ++ + + +K ++E +
Sbjct: 512 DKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIID 570
Query: 4311 VNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 4365
P L ++ + R S P C + CSHLCL RP G CACP G I T
Sbjct: 571 QLPDLMGLKATNVHRVIGSNP--CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKT 626
Score = 185 bits (469), Expect = 1e-45
Identities = 106/268 (39%), Positives = 152/268 (56%), Gaps = 19/268 (7%)
Query: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173
AIKR ES +N +V + + PDG+A DW+G +YW+D + RIEV+ LDG
Sbjct: 74 AIKRTEFNKTESVQNVVVSGL-------LSPDGLACDWLGEKLYWTDSETNRIEVSNLDG 126
Query: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233
RK L +LDQP AIA++P G M+WTDWG+ PKIE A M+G R I++ ++ WP G
Sbjct: 127 SLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNG 186
Query: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292
L++DY ++YW+D K + I DGT+R+ + K ++ +P++L +FED LYW
Sbjct: 187 LTLDY-EEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTH 245
Query: 4293 EVWKQNKF-GQGKKE-KTLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRP- 4346
+ NK+ G+G +E + + +P + F Q R + N C CSHLCL+ P
Sbjct: 246 SILACNKYTGEGLREIHSDIFSP--MDIHAFSQQR-QPNATNPCGIDNGGCSHLCLMSPV 302
Query: 4347 -GGYSCACPQGSSFIEGSTTECDAAIEL 4373
Y CACP G +E T D A EL
Sbjct: 303 KPFYQCACPTGVKLLENGKTCKDGATEL 330
Score = 176 bits (446), Expect = 5e-43
Identities = 117/353 (33%), Positives = 183/353 (51%), Gaps = 32/353 (9%)
Query: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
N C E+ G C C C C GF +SD K C + LL IR+
Sbjct: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM--KTCIVPEA--FLLFSRRADIRRI 645
Query: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
+L + + + +A D+D D + +Y+T I RA++
Sbjct: 646 SLETNNNNVAIPLTGVKEASALDFDVTD---NRIYWT----DISLKTISRAFMNG----- 693
Query: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
+ L V+ L Y P+G+AVDW+G+++YW+D RIEV+KLDG++R+ L+ DLD P
Sbjct: 694 SALEHVVEFGLDY---PEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSP 750
Query: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
A+A++P G M+WT+WG +PKI+ A M+G +R LV ++G GL+IDY R+YW+
Sbjct: 751 RALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR-RLYWT 808
Query: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307
D ++IE+ G +R VIA + +P+ L ++D +YW + + + NK + +
Sbjct: 809 DLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANK--TSGQNR 866
Query: 4308 TLVVN--PWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRP-GGYSCACP 4354
T++ ++ + +FH R +S N C CSHLCL P GG+ C CP
Sbjct: 867 TIIQGHLDYVMDILVFHSSR--QSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Score = 162 bits (409), Expect = 9e-39
Identities = 99/312 (31%), Positives = 163/312 (52%), Gaps = 10/312 (3%)
Query: 711 LIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKI 770
L+++++ +R + T + +E+ + V G +DF I++SD+S+ I + +
Sbjct: 23 LLYANRRDLRLVDAT-NGKENATIVVGGLEDA-AAVDFVFSHGLIYWSDVSEEAIKRTEF 80
Query: 771 DGTGR-EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNP 828
+ T + + + + + + LA DW+ + LYWTDS I V L R+ + Q L+ P
Sbjct: 81 NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
Query: 829 RSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVD 888
R++ + P +G++++TDW KI RA DGS +IN+ + WPNGL +D+ +LYW D
Sbjct: 141 RAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWAD 200
Query: 889 AYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMT 948
A + I S DG +R+ + + HPF L +F + L++TDW +I+ K G +
Sbjct: 201 AKLNFIHKSNLDGTNRQAVVK-GSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLR 259
Query: 949 VIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCF--PVPNFQRVCGCPYGMRL 1006
I S I + + ++ Q NA N NG CSH C PV F + C CP G++L
Sbjct: 260 EIHSDIFSPMDIHAFSQQRQP--NATNPCGIDNGGCSHLCLMSPVKPFYQ-CACPTGVKL 316
Query: 1007 ASNHLTCEGDPT 1018
N TC+ T
Sbjct: 317 LENGKTCKDGAT 328
Score = 119 bits (297), Expect = 9e-26
Identities = 105/415 (25%), Positives = 174/415 (41%), Gaps = 73/415 (17%)
Query: 3975 CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCAD 4034
C C + GGF+C C A + N +RT C
Sbjct: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRT--------------------------CSAPT 933
Query: 4035 GFTSMSDRPG--KRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWD 4092
F S + + E SP ++LP + ++A+DYD
Sbjct: 934 TFLLFSQKSAINRMVIDEQQSPDIILP------------------IHSLRNVRAIDYD-- 973
Query: 4093 PKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWV 4152
P D L + SR I++A + G +V V + +QP +++D
Sbjct: 974 PLDKQLYWI-------DSRQNMIRKAQ-EDGSQGFTVVVSSVPSQ-NLEIQPYDLSIDIY 1024
Query: 4153 GRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD-WGKEPKIE 4211
R+IYW+ I V +LDGR ++ + D+P A+ VNP+ G M++T+ + PKIE
Sbjct: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
Query: 4212 SAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIA-KE 4270
A ++G +R +L F L P L++D +++W+D IE+ G +R V+
Sbjct: 1085 RAALDGTEREVLFFSGLSKPIALALD-SRLGKLFWADSDLRRIESSDLSGANRIVLEDSN 1143
Query: 4271 AMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSV 4330
+ P L +FE+ LYWI K++ + K + G+ + K L+ + +L +
Sbjct: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR 1203
Query: 4331 PNLCKQI---CSHLCLLRPGGYS-CACPQGSSFIEGSTTECDAAIELPINLPPPC 4381
+ C Q CSH+CL++ G + C+CP ++ EL PP C
Sbjct: 1204 QHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD---------ELSCGEPPTC 1249
Score = 114 bits (284), Expect = 3e-24
Identities = 68/171 (39%), Positives = 83/171 (48%), Gaps = 14/171 (8%)
Query: 1060 CGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH 1119
C N CS G G RC V DE +C P +C Q+TC
Sbjct: 1207 CAQDNGGCSHICLVKGDGTT-----RCSCPMHLVLLQDELSCGE--PPTCSPQQFTCFTG 1259
Query: 1120 Q--CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDG 1177
+ CI W CD +C D SDE NC C SQF C + +CID + C+GD +C D
Sbjct: 1260 EIDCIPVAWRCDGFTECEDHSDELNC---PVCSESQFQCASGQCIDGALRCNGDANCQDK 1316
Query: 1178 SDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC-PTRPP 1227
SDE C + C QF+CA+G +CIG +CD DCSD SDE C PT P
Sbjct: 1317 SDEKNCEVLCLIDQFRCANG-QCIGKHKKCDHNVDCSDKSDELDCYPTEEP 1366
Score = 112 bits (279), Expect = 1e-23
Identities = 53/126 (42%), Positives = 72/126 (57%), Gaps = 3/126 (2%)
Query: 98 DERQDCSQSTCSSHQITCSNGQ--CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNG 155
DE TCS Q TC G+ CIP +RCD +C D +DE +C + Q C +G
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG 1298
Query: 156 ACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEH 215
C + + +C+ +C+D SDE NC +CL ++F C NG+CI + CDH+ DC D SDE
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDEL 1358
Query: 216 ACNYPT 221
C YPT
Sbjct: 1359 DC-YPT 1363
Score = 110 bits (276), Expect = 2e-23
Identities = 58/132 (43%), Positives = 76/132 (57%), Gaps = 8/132 (6%)
Query: 3710 DEQGC-EERTCHPVGDFRCKNHH--CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 3766
DE C E TC P F C CIP+ W+CDG +C D+SDE NC C+ES+F+C
Sbjct: 1239 DELSCGEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQC 1295
Query: 3767 VNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDA 3826
+ QCI C+ +C D SDE++CE+ C + F+C +G C+ KCD + DC D
Sbjct: 1296 ASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDK 1354
Query: 3827 SDEADC-PTRFP 3837
SDE DC PT P
Sbjct: 1355 SDELDCYPTEEP 1366
Score = 110 bits (274), Expect = 4e-23
Identities = 61/151 (40%), Positives = 80/151 (52%), Gaps = 15/151 (9%)
Query: 4 GPAAVACTLLLALV----ACLAPASGQECDSAHFRCGSGH--CIPADWRCDGTKDCSDDA 57
G +C + L L+ +C P + C F C +G CIP WRCDG +C D +
Sbjct: 1224 GTTRCSCPMHLVLLQDELSCGEPPT---CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHS 1280
Query: 58 DEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSN 117
DE+ C V C + F+C S GQCI + C+ D +C D SDE+ + C Q C+N
Sbjct: 1281 DELNCPV--CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKN--CEVLCLIDQFRCAN 1335
Query: 118 GQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148
GQCI +CDH DC D +DE DC YPT E
Sbjct: 1336 GQCIGKHKKCDHNVDCSDKSDELDC-YPTEE 1365
Score = 103 bits (258), Expect = 3e-21
Identities = 51/127 (40%), Positives = 67/127 (52%), Gaps = 11/127 (8%)
Query: 3750 DEENCA-PRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCT 3806
DE +C P C+ +F C + CIP W CD + +C D+SDE +C + C FQC
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCA 1296
Query: 3807 SGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDD 3866
SG C+ L+C+G A+C D SDE +C C F C N CI + KCD + D
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCE------VLCLIDQFRCANGQCIGKHKKCDHNVD 1350
Query: 3867 CGDGSDE 3873
C D SDE
Sbjct: 1351 CSDKSDE 1357
Score = 99.8 bits (247), Expect = 6e-20
Identities = 61/176 (34%), Positives = 80/176 (45%), Gaps = 19/176 (10%)
Query: 2937 EDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVC-DGDVDCTDGYDENQNCTRRTCSE 2995
E ++H C N S V R P V ++ C + TCS
Sbjct: 1201 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP---------PTCSP 1251
Query: 2996 NEFTCGYGL--CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDE 3053
+FTC G CIP +RCD +C D+SDE C C ++QF C +G+CI C+
Sbjct: 1252 QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCIDGALRCNG 1309
Query: 3054 DNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
D +C D SDE E C +F+C NG+CI K C+H DC D SDE C
Sbjct: 1310 DANCQDKSDE-----KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 99.8 bits (247), Expect = 6e-20
Identities = 62/188 (32%), Positives = 88/188 (46%), Gaps = 32/188 (17%)
Query: 138 DENDC-QYPTC--EQLTCDNGA--CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
DE C + PTC +Q TC G C + +CD +C D SDE+NC +C ++F C +
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCAS 1297
Query: 193 GECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252
G+CI A C+ D +CQD SDE C C QF C +G+CI ++ CD DC D D
Sbjct: 1298 GQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
Query: 253 EDGCESGPHDVHKCSPREWSCPESGRCI--------------SIYKVCDGILDCPGREDE 298
E C P E P++ + ++Y +C +L CP + +
Sbjct: 1357 E----------LDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRML-CPRMKGD 1405
Query: 299 NNTSTGKY 306
T T Y
Sbjct: 1406 GETMTNDY 1413
Score = 97.8 bits (242), Expect = 2e-19
Identities = 54/129 (41%), Positives = 67/129 (51%), Gaps = 9/129 (6%)
Query: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIP 3007
CS +F C + CIP +W CDG +C D DE NC CSE++F C G CI
Sbjct: 1249 CSPQQFTCFTG---EIDCIPVAWRCDGFTECEDHSDE-LNCP--VCSESQFQCASGQCID 1302
Query: 3008 KIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHL 3067
RC+ +C D SDE+ C C +QF C NG+CI K CD + DC D SDEL
Sbjct: 1303 GALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD-- 1359
Query: 3068 CHTPEPTCP 3076
C+ E P
Sbjct: 1360 CYPTEEPAP 1368
Score = 97.1 bits (240), Expect = 4e-19
Identities = 56/134 (41%), Positives = 69/134 (51%), Gaps = 12/134 (8%)
Query: 1179 DEVGC--VLNCTASQFKCASGD-KCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEF 1235
DE+ C C+ QF C +G+ CI V RCDG +C D+SDE CP +C +F
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-----VCSESQF 1293
Query: 1236 QCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDND 1295
QC G CI C+G +C SDE N V C F C NG CI + CD + D
Sbjct: 1294 QCAS-GQCIDGALRCNGDANCQDKSDEKNCEV--LCLIDQFRCANGQCIGKHKKCDHNVD 1350
Query: 1296 CGDMSDEKDC-PTQ 1308
C D SDE DC PT+
Sbjct: 1351 CSDKSDELDCYPTE 1364
Score = 94.0 bits (232), Expect = 3e-18
Identities = 52/127 (40%), Positives = 67/127 (52%), Gaps = 10/127 (7%)
Query: 2813 DEKNCPDR-TCQSGYTKCHNSNI-CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQ 2870
DE +C + TC C I CIP + CDG +C D+SDE CS S+FQ
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCPVCSESQFQ 1294
Query: 2871 CASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDND 2930
CASG+CI C+ + +C D SDE + E CL D+F+C G+CI CD + D
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEK----NCEVLCLIDQFRCANGQCIGKHKKCDHNVD 1350
Query: 2931 CGDMSDE 2937
C D SDE
Sbjct: 1351 CSDKSDE 1357
Score = 92.0 bits (227), Expect = 1e-17
Identities = 59/167 (35%), Positives = 83/167 (49%), Gaps = 24/167 (14%)
Query: 143 QYPTCEQLTCDNGACYNT-------SQKCDWKVDCRDSSDEINCTE--ICLHNEFSCGNG 193
Q+P C Q DNG C + + +C + DE++C E C +F+C G
Sbjct: 1204 QHP-CAQ---DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTG 1259
Query: 194 E--CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNG 251
E CIP A+ CD +C+D SDE C P C QF C SG+CI C+G+ +C+D
Sbjct: 1260 EIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCIDGALRCNGDANCQDKS 1317
Query: 252 DEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
DE CE C ++ C +G+CI +K CD +DC + DE
Sbjct: 1318 DEKNCEV------LCLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 89.0 bits (219), Expect = 1e-16
Identities = 47/112 (41%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 3683 EFSCKTN-YRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDG 3741
+F+C T CIP C+G +C D+SDE C C F+C + CI +C+G
Sbjct: 1253 QFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSE-SQFQCASGQCIDGALRCNG 1309
Query: 3742 QNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
+C D SDE+NC C +FRC N QCI CDH DC D SDE DC
Sbjct: 1310 DANCQDKSDEKNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 86.3 bits (212), Expect = 7e-16
Identities = 52/132 (39%), Positives = 66/132 (50%), Gaps = 15/132 (11%)
Query: 2898 SCGHSERTCLADEFKCDGGR--CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLC 2955
SCG TC +F C G CIP W CDG +C D SDE CS+S+F C
Sbjct: 1242 SCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-----LNCPVCSESQFQC 1295
Query: 2956 VNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRH 3015
+ +CI + C+GD +C D DE +NC C ++F C G CI K +CD +
Sbjct: 1296 ASG-----QCIDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348
Query: 3016 NDCGDYSDERGC 3027
DC D SDE C
Sbjct: 1349 VDCSDKSDELDC 1360
Score = 84.3 bits (207), Expect = 3e-15
Identities = 59/171 (34%), Positives = 77/171 (45%), Gaps = 26/171 (15%)
Query: 3807 SGHCVHSEL-KCDGSADC------LDASDEADC---PTRFPDGAYCQATMFECKNHVCIP 3856
+G C H L K DG+ C + DE C PT P C +C IP
Sbjct: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDC-----IP 1265
Query: 3857 PYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDET 3916
W+CDG +C D SDE L+ P S ++F+C + +CI CNG +C D +DE
Sbjct: 1266 VAWRCDGFTECEDHSDE-----LNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDE- 1319
Query: 3917 EEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKE 3967
K C +++C NG CI CD DC D SDEL C +E
Sbjct: 1320 -----KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEE 1365
Score = 79.0 bits (193), Expect = 1e-13
Identities = 52/146 (35%), Positives = 62/146 (42%), Gaps = 18/146 (12%)
Query: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGI-CIPNFWECDGHPDCLYGSDE 1262
T RC DE C P C +F C I CIP W CDG +C SDE
Sbjct: 1225 TTRCSCPMHLVLLQDELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
Query: 1263 HNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT----QPFRCPSWQWQ 1318
N V C S F C +G CI A C+ D +C D SDEK+C FRC + Q
Sbjct: 1283 LNCPV---CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQ-- 1337
Query: 1319 CLGHNICVNLSVVCDGIFDCPNGTDE 1344
C+ CD DC + +DE
Sbjct: 1338 ------CIGKHKKCDHNVDCSDKSDE 1357
Score = 68.2 bits (165), Expect = 2e-10
Identities = 37/94 (39%), Positives = 49/94 (52%), Gaps = 3/94 (3%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87
C + F+C SG CI RC+G +C D +DE C V+ C F+C + GQCI C
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL-CLIDQFRC-ANGQCIGKHKKC 1345
Query: 88 DQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCI 121
D + DC D SDE DC + + Q T + G I
Sbjct: 1346 DHNVDCSDKSDE-LDCYPTEEPAPQATNTVGSVI 1378
Score = 67.8 bits (164), Expect = 2e-10
Identities = 53/168 (31%), Positives = 71/168 (42%), Gaps = 25/168 (14%)
Query: 2986 QNCTRRTCSENEFTCGYGLCIPK---IFRCDRHNDCGDYSDERGCLYQ-TCQQNQFTCQN 3041
Q + C+++ C + +C+ K RC DE C TC QFTC
Sbjct: 1200 QEYRQHPCAQDNGGCSH-ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFT 1258
Query: 3042 GR--CISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDD 3099
G CI + CD +C D SDEL C P C +F+C +G+CI+ CN +
Sbjct: 1259 GEIDCIPVAWRCDGFTECEDHSDELN--C----PVCSESQFQCASGQCIDGALRCNGDAN 1312
Query: 3100 CLDNSDEKGCGI------NECHDPSISG----CDHN--CTDTLTSFYC 3135
C D SDEK C + C + G CDHN C+D C
Sbjct: 1313 CQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 51.6 bits (122), Expect = 2e-05
Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 4172 DGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWP 4231
+G+ ++ L+ AA+ GL++W+D +E + + E +V L P
Sbjct: 38 NGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSP 97
Query: 4232 TGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMN---PYSLDIFEDQLYWIS 4288
GL+ D+L +++YW+D + + IE DG+ R+V+ + ++ +LD +YW
Sbjct: 98 DGLACDWL-GEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYW-- 154
Query: 4289 KEKGEVWKQNKFGQGKKEKTLVVN 4312
+ GEV K + G + +++N
Sbjct: 155 TDWGEVPKIERAGMDGSSRFIIIN 178
Score = 42.0 bits (97), Expect = 0.014
Identities = 24/57 (42%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 3493 CPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCP 3549
C D S C +C QF CAN + CI KCD DCSD SDEL P
Sbjct: 1307 CNGDANCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
Score = 38.1 bits (87), Expect = 0.21
Identities = 28/118 (23%), Positives = 43/118 (36%), Gaps = 40/118 (33%)
Query: 1353 CSDFNGGCTHECVQEPFGA-KCLCPLGFLLANDSKTCED---------------ID---- 1392
C+ NGGC+H C+ + G +C CP+ +L D +C + ID
Sbjct: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
Query: 1393 --ECDILGSCSQHCYNMR------------------GSFRCSCDTGYMLESDGRTCKV 1430
CD C H + G+ RC+ D +SD + C+V
Sbjct: 1267 AWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV 1324
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 680 bits (1755), Expect = 0.0
Identities = 464/1435 (32%), Positives = 720/1435 (50%), Gaps = 100/1435 (6%)
Query: 1428 CKVTASESLLLLVASQNKII---ADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
C A+ S LLL A++ + A V + + S +E+ + AVDF G ++W+D
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAA---AVDFQFSKGAVYWTD 81
Query: 1485 ATQGKTWSAFQNGTDRRV--VFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSH 1542
++ + N T V V S ++ + +A DWVG+ LYWTD IEV+ ++G+
Sbjct: 82 VSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTS 141
Query: 1543 RTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCG 1602
R VL ++L PR +ALDP ++W+DWG PRIERA MDGS R +IV I+WP G
Sbjct: 142 RKVLFWQDLDQPRAIALDPAHG--YMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNG 199
Query: 1603 LTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRAT 1662
LTID + LY+ D+ L ++ + +G R++V+ L HP+ALTL D++YWTD T
Sbjct: 200 LTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSL--THPFALTLSGDTLYWTDWQT 257
Query: 1663 RRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGP 1720
R + NK GG + ++ + P+ I + +QP C CSHLCLLS P
Sbjct: 258 RSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEP 317
Query: 1721 HFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNG 1780
FY+C CP+G L + C + L+ R+ + ISL+ D ++ + I++
Sbjct: 318 -FYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP-DFTDIVLQVDDIRHA 375
Query: 1781 LDVEFDDAEQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTN 1839
+ +++D E Y+YW ++ I R DG+ + + P +A+DW++RNLY T+
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD-GIAVDWVARNLYWTD 434
Query: 1840 PRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAK 1899
T IEV L+G RK L++ D + P I + P G +YW+D G + K
Sbjct: 435 TGTDRIEVTRLNG--TSRKILVSED-----LDEPRAIALHPVMGLMYWTDWGEN----PK 483
Query: 1900 IASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH- 1958
I AN+DG + L +L + LD++E KLYW IE NVDGT R L+
Sbjct: 484 IECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLED 543
Query: 1959 QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAES 2018
+L H +G + F+Y+TD Q IERV K + +++ D +P+L GL+ +
Sbjct: 544 KLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVV-G 601
Query: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSL 2078
+N C++ C +C P C C G +L D ++C +F+V + +AI SL
Sbjct: 602 TNPCADRNGGCSHLCFFTPHAT-RCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
Query: 2079 ELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIV 2138
E +++++ +P+ G + A +D DVS+ IYW D S I R +GSS+ ++V
Sbjct: 661 E-TNNNDVAIPLTGV-KEASALDFDVSNNHIYWTDVSL-----KTISRAFMNGSSVEHVV 713
Query: 2139 THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVD 2198
G+ + G+AVDW+ NLY+ + + IEV R++ +R+VL+ +D PR + +D
Sbjct: 714 EFGL--DYPEGMAVDWMGKNLYWADTGTNR--IEVARLDGQFRQVLVWRDLDNPRSLALD 769
Query: 2199 PKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDII 2258
P Y++W ++G +P+I R+F+D TN LV + + L +D +D +YW D ++I
Sbjct: 770 PTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMI 828
Query: 2259 ARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRD 2318
+ G+ VI P P+G+T + + I W D NL I +A K T+I+
Sbjct: 829 ESSNMLGQERVVI--ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNR--TLIQG 884
Query: 2319 NINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCA-FGTLQS 2377
+++++ D+ +F S + N C+ NNG C LC A+PG H +C CA TL
Sbjct: 885 HLDFVMDILVF------HSSRQDGLNDCMHNNGQCGQLCLAIPGGH--RCGCASHYTLDP 936
Query: 2378 DGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFT- 2436
+NC+ T FL+F+ +++ + D ++ ++ R V ++DYD + IY+
Sbjct: 937 SSRNCSPPT-TFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD 995
Query: 2437 --QNLA----SGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMI 2490
QN+ G +LS G + ++ D +R ++++ I
Sbjct: 996 GRQNIKRAKDDGTQPFVLTSLSQGQNPDR-------QPHDLSIDIYSRTLFWTCEATNTI 1048
Query: 2491 NSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWADW-DTHAKIERATLGGNFRVPIVN 2547
N G V+ R KPRAIV++ +GYLY+ + D AKIERA L G R +
Sbjct: 1049 NVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFT 1108
Query: 2548 SSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA-AVHAFGLTLYGQYIY 2606
+ L+ P L +D L+WVDA L+RIE L+G +R + +A V GLT+ G+++Y
Sbjct: 1109 TGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLY 1168
Query: 2607 WTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCN-NPCEQFNGGCSHI 2665
W D Q I R K G + + ++ GI+ V + ++ + +PC + NGGCSHI
Sbjct: 1169 WIDRQQQMIERVEKTTGDKRTRI-QGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHI 1227
Query: 2666 C-APGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDND 2722
C A G C CP + L N C C F C+ G CI W+CD
Sbjct: 1228 CIAKGDGTPRCSCP--VHLVLLQNLLTC--GEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
Query: 2723 NDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNA 2782
+C D SDE CS F CA G+CV RCD DC D SDEA DC+A
Sbjct: 1284 PECDDQSDEE----GCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEA-----DCDA 1334
Query: 2783 ---TTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNI 2834
+F C + +C+ + C+ +C D SDE C S + H+S I
Sbjct: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDG--SDELMCEITKPPSDDSPAHSSAI 1387
Score = 488 bits (1256), Expect = e-137
Identities = 310/982 (31%), Positives = 514/982 (52%), Gaps = 54/982 (5%)
Query: 1398 GSCSQHCYNMRGS--FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQV 1455
G CS C + C+C TG L+ +GRTCK A E LLL + + I+ T
Sbjct: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLD-TPDF 362
Query: 1456 HNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIA 1515
+I V++ + +A+D+D + G ++W+D A+ +G+ + + ++ I + IA
Sbjct: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIA 422
Query: 1516 IDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH 1575
+DWV RNLYWTD + IEV++++G+ R +L+S++L PR +AL P M L++W+DWG
Sbjct: 423 VDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMG--LMYWTDWGE 480
Query: 1576 HPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQV 1635
+P+IE A++DG R V+V + WP GL +D LY+ D+ D ++ + +G RR +
Sbjct: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
Query: 1636 IASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPS 1695
+ L H + TL D +YWTD R + R +K ++ V++ + +G+ AV+ +
Sbjct: 541 LEDKL--PHIFGFTLLGDFIYWTDWQRRSIERVHKVK-ASRDVIIDQLPDLMGLKAVNVA 597
Query: 1696 KQPNSVNPCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
K + NPCA CSHLC + PH C CP G L D+ C+ + FL+ +
Sbjct: 598 KVVGT-NPCADRNGGCSHLCFFT---PHATRCGCPIGLELLSDMKTCI-VPEAFLVFTSR 652
Query: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRT 1812
I ISL E +ND +P+ G++ ++FD + +IYW + + I R +G++
Sbjct: 653 AAIHRISL--ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVE 710
Query: 1813 VFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGF 1872
+ P +A+DW+ +NLY + T IEV L G ++R+ L+ D +
Sbjct: 711 HVVEFGLDYPE-GMAVDWMGKNLYWADTGTNRIEVARLDG--QFRQVLVWRD-----LDN 762
Query: 1873 PIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQK 1932
P + +DP +G +YW++ G G P +I A MDGT+ TL + +T+D +Q+
Sbjct: 763 PRSLALDPTKGYIYWTEWG---GKP-RIVRAFMDGTNCMTL-VDKVGRANDLTIDYADQR 817
Query: 1933 LYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGA 1992
LYW +IE N+ G +R+++ L HP+G+ + ++Y+TD IER DK +G
Sbjct: 818 LYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGR 877
Query: 1993 NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLN 2052
N+ +++ ++ + + V+H + + N C +N C Q+CL +PGG C CA+ + L+
Sbjct: 878 NRTLIQGHLDFVMDILVFH-SSRQDGLNDCMHNNGQCGQLCLAIPGG-HRCGCASHYTLD 935
Query: 2053 PDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWC 2112
P +R+CSP +F++ S SAI + + ++P+ G RN +D D FIYW
Sbjct: 936 PSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGL-RNVKAIDYDPLDKFIYWV 994
Query: 2113 DFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSET 2169
D + I+R K DG+ + + G+N R +++D + L++T +
Sbjct: 995 DGRQN------IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWT--CEATN 1046
Query: 2170 LIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVL 2228
I V R++ V+L+ D PR IVV+ + YL++ + R KIER+ LD T R VL
Sbjct: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Query: 2229 VSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFEN 2288
+ G++ P L VD + G ++WVD L I ++G N + + P G+T+
Sbjct: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLE-DANIVQPLGLTILGK 1165
Query: 2289 SIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLE 2348
+ W+DR + I + K + T I+ + L + V+ S E + +PC
Sbjct: 1166 HLYWIDRQQQMIERVEK--TTGDKRTRIQGRVAHLTGI----HAVEEVSLEEFSAHPCAR 1219
Query: 2349 NNGGCSHLCFALPGLHTPKCDC 2370
+NGGCSH+C A G TP+C C
Sbjct: 1220 DNGGCSHICIA-KGDGTPRCSC 1240
Score = 386 bits (992), Expect = e-106
Identities = 258/823 (31%), Positives = 399/823 (48%), Gaps = 68/823 (8%)
Query: 356 GICDQKCESRPGRHLCHCEEGY-ILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSF 414
G C C P C C G +L + C ++F ++F++ IH
Sbjct: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF----LVFTSR-----AAIH---- 656
Query: 415 RILVESQNRGVAVGVA---------FHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVS 465
RI +E+ N VA+ + F ++WTD + +NG +++ V+
Sbjct: 657 RISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFG 716
Query: 466 VETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLF 525
++ PE +AVDW+ +Y +T NRI++ LDG +R L+ +L +PR +A+DPT GY++
Sbjct: 717 LDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
Query: 526 FSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVT 585
+++W G+P++ RAFMDG+N LV K+G +T+D +R+YW D + IE+
Sbjct: 777 WTEW---GGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSN 832
Query: 586 YDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRP 645
G +R + +PHPFG++ + +++TDW ++ +A+K + N +
Sbjct: 833 MLGQERVVIADD---LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFV 889
Query: 646 YGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705
+ V+HS RQ N C NNG C Q+C+ G RC C + LD R+C
Sbjct: 890 MDILVFHSSRQD-GLNDCMHNNGQCGQLCLAIPG------GHRCGCASHYTLDPSSRNCS 942
Query: 706 AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
FL+FS + AI + D+++P+ G + ID+D D I++ D + I
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRN-VKAIDYDPLDKFIYWVD-GRQNI 1000
Query: 766 FKQKIDGTGREILAA-----NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRT 820
+ K DGT +L + N L+ D S+ L+WT +I+V RL+ +
Sbjct: 1001 KRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGV 1060
Query: 821 VVQ-YLNNPRSVVVHPFAGYLFFTDW-FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAID 878
V++ + PR++VV+ GYL+FT+ R AKI RA DG+ + T L P L +D
Sbjct: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
Query: 879 WAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIR 938
+L+WVDA +IE G +R L + P GL I G+HL++ D + I R
Sbjct: 1121 NTLGKLFWVDADLKRIESCDLSGANRLTL-EDANIVQPLGLTILGKHLYWIDRQQQMIER 1179
Query: 939 VRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVC 998
V K G + T I+ +A++ + + + + + + NG CSH C + C
Sbjct: 1180 VEKTTGDKRTRIQGRVAHLTGIHAVE-EVSLEEFSAHPCARDNGGCSHICIAKGDGTPRC 1238
Query: 999 GCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGR--CVPNYYLCDGVDDCHDNSD 1056
CP + L N LTC EPPT C F C G C+P + CDG +C D SD
Sbjct: 1239 SCPVHLVLLQNLLTC-----GEPPT--CSPDQFACATGEIDCIPGAWRCDGFPECDDQSD 1291
Query: 1057 EQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC 1116
E+ C CS++ F C G+C+ RCD DC D SDE +C A CL Q+ C
Sbjct: 1292 EEGC----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC----DAICLPNQFRC 1343
Query: 1117 DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNH 1159
+ QC+ CD+ DC DGSDE C E +P + P H
Sbjct: 1344 ASGQCVLIKQQCDSFPDCIDGSDELMC---EITKPPSDDSPAH 1383
Score = 374 bits (960), Expect = e-102
Identities = 208/623 (33%), Positives = 335/623 (53%), Gaps = 22/623 (3%)
Query: 396 IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDIN- 454
++F+N RD+ + D G + A V F + V+WTD + + +N
Sbjct: 35 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQ 94
Query: 455 -GLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPR 513
G +Q V+ + +P+ LA DWV K+Y +++ NRI++ NL+G+ R L ++L PR
Sbjct: 95 TGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPR 154
Query: 514 GIAVDPTVGYLFFSDWESLSGE-PKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVY 572
IA+DP GY++++DW GE P++ERA MDGS RK +V + + WP G+T+D+ +++Y
Sbjct: 155 AIALDPAHGYMYWTDW----GETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLY 210
Query: 573 WVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632
W D++ +I DG R+ VV G + HPF ++L +++TDW ++ NK T
Sbjct: 211 WADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKRTG 268
Query: 633 TNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCT 692
+ A P + V RQP+ C+++NGGC +C+LS + C C
Sbjct: 269 GKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPF----YTCACP 324
Query: 693 FGFQLDTDERHCIA-VQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQ 751
G QL + R C A + L+ + + +R I D+++ V + + ID+D
Sbjct: 325 TGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVD-DIRHAIAIDYDPL 383
Query: 752 DSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVM 811
+ ++++D I + +DG+G + L + + + +A DW+++NLYWTD+ I V
Sbjct: 384 EGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVT 443
Query: 812 RLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870
RL +R+ +V + L+ PR++ +HP G +++TDW KI A DG ++N +LG
Sbjct: 444 RLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLG 503
Query: 871 WPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTD 930
WPNGLA+D +LYW DA DKIE DG RR L +++ H FG + G+ +++TD
Sbjct: 504 WPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE-DKLPHIFGFTLLGDFIYWTD 562
Query: 931 WRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFP 990
W+ +I RV K VI + ++ LK+ +V G+N C NG CSH CF
Sbjct: 563 WQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVVGTNPC---ADRNGGCSHLCFF 618
Query: 991 VPNFQRVCGCPYGMRLASNHLTC 1013
P+ R CGCP G+ L S+ TC
Sbjct: 619 TPHATR-CGCPIGLELLSDMKTC 640
Score = 305 bits (780), Expect = 9e-82
Identities = 221/755 (29%), Positives = 359/755 (47%), Gaps = 91/755 (12%)
Query: 1322 HNICVNLSVVCDGIFDCPN--GTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGF 1379
H + + V+ D + D + + + N C+D NGGC+H C P +C CP+G
Sbjct: 572 HKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGL 631
Query: 1380 LLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLL 1439
L +D KTC E+ L+
Sbjct: 632 ELLSDMKTC------------------------------------------IVPEAFLVF 649
Query: 1440 V--ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNG 1497
A+ ++I ++ + V + V+ S A+DFD + I+W+D + AF NG
Sbjct: 650 TSRAAIHRISLETNNNDVAIPLTGVKEAS---ALDFDVSNNHIYWTDVSLKTISRAFMNG 706
Query: 1498 TDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGL 1557
+ V + + E +A+DW+G+NLYW D IEV+++DG R VL+ ++L NPR L
Sbjct: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
Query: 1558 ALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDS 1617
ALDP + ++W++WG PRI RA MDG+ +V DK+ LTIDY ++ LY+ D
Sbjct: 767 ALDP--TKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDL 823
Query: 1618 YLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQS 1677
+ ++ + G R VIA DL HP+ LT + D +YWTD + RA+K G N++
Sbjct: 824 DTNMIESSNMLG-QERVVIADDL--PHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRT 880
Query: 1678 VVMYNIQWPLGIVAVHPSKQPNSVNPCAFS--RCSHLCLLSSQGPHFYSCVCPSGWSLSP 1735
++ ++ + + I+ H S+Q + +N C + +C LCL G + C C S ++L P
Sbjct: 881 LIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLAIPGG---HRCGCASHYTLDP 936
Query: 1736 DLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWV 1795
NC FL+ ++ I + + + S D ++P+ G++N +++D +++IYWV
Sbjct: 937 SSRNC-SPPTTFLLFSQKSAISRM-IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV 994
Query: 1796 ENPGEIHRVKTDGTNRTVFASISM-VGPSM---NLALDWISRNLYSTNPRTQSIEVLTLH 1851
+ I R K DGT V S+S P +L++D SR L+ T T +I V L
Sbjct: 995 DGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLS 1054
Query: 1852 GDIRYRKTLIANDGTALGVGF------PIGITVDPARGKLYWSDQGTDSGVPAKIASANM 1905
G+ A+GV P I V+ RG LY+++ + AKI A +
Sbjct: 1055 GE-------------AMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA---AKIERAAL 1098
Query: 1906 DGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH-QLSHPW 1964
DGT + LFT L + +D KL+W IE ++ G +R+ L + P
Sbjct: 1099 DGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPL 1158
Query: 1965 GIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAE-SSNGCS 2023
G+ + LY+ D Q ++IERV+K TG + ++ V +L G+ + E S++ C+
Sbjct: 1159 GLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCA 1218
Query: 2024 NNMNACQQICLPVPGGLFSCACATGFKLNPDNRSC 2058
+ C IC+ G C+C L + +C
Sbjct: 1219 RDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC 1253
Score = 253 bits (647), Expect = 2e-66
Identities = 122/320 (38%), Positives = 186/320 (58%), Gaps = 13/320 (4%)
Query: 3191 CRQNSNIEPYLIFSNRYYLRNLTIDGYFY--SLILEGLDNVVALDFDRVEKRLYWIDTQR 3248
C + P L+F+NR +R + G ++++ GL++ A+DF + +YW D
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 3249 QVIERMFLNKTNK--ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRM 3306
+ I++ +LN+T + ++ L + + LA DWV +KLYW D+ + + V++LNG R++
Sbjct: 85 EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 144
Query: 3307 LAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEW 3366
L +D PR +AL P +GY+YW DWG I R GMDG+ + +I+ + + W
Sbjct: 145 LFWQDLD--------QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYW 196
Query: 3367 PNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWN 3426
PNG+TID LYWADA L +I ++L+G R V +G+L HPFA+T+ DT+YWTDW
Sbjct: 197 PNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQ 256
Query: 3427 TRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGG 3486
TR++ NK G R+ +++ + P DI V RQP C +NGGCSHLCL+ P
Sbjct: 257 TRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSE 316
Query: 3487 KGFTCECPDDFRTLQLSGST 3506
+TC CP + LQ +G T
Sbjct: 317 PFYTCACPTGVQ-LQDNGRT 335
Score = 231 bits (589), Expect = 1e-59
Identities = 157/486 (32%), Positives = 233/486 (47%), Gaps = 34/486 (6%)
Query: 3153 IDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYL-RN 3211
+++C C Q C + G + C CA Y +P + C + +L+FS + + R
Sbjct: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTT---FLLFSQKSAISRM 959
Query: 3212 LTIDGYFYSLIL--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIIN--- 3266
+ D + LIL GL NV A+D+D ++K +YW+D RQ I+R + T + +
Sbjct: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDG-RQNIKRAKDDGTQPFVLTSLSQ 1018
Query: 3267 ----HRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDN 3322
R P L++D SR L+W + + V L+G ++ + D
Sbjct: 1019 GQNPDRQP--HDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRD--------K 1068
Query: 3323 PRGLALHPQYGYLYWADWGHRAY-IGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYW 3381
PR + ++ + GYLY+ + RA I R +DGT + V+ +T L P + +D T L+W
Sbjct: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
Query: 3382 ADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNR 3441
DA L IE DL G +R T+ D + P +TI +YW D + +E+ K G R
Sbjct: 1129 VDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKR 1188
Query: 3442 QTLVNTTHRPFDIH-VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
+ IH V + ++PC +NGGCSH+C+ K G C CP L
Sbjct: 1189 TRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTP-RCSCPVHLVLL 1247
Query: 3501 QLSGSTYCMPMCSSTQFLCANNE-KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQ 3559
Q + P CS QF CA E CIP W+CDG +C D SDE CP C QF
Sbjct: 1248 QNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEG-CP--VCSAAQFP 1304
Query: 3560 CSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
C+ G C + C+ +C D SDE + C N+++CA+ +C+ QCD+F DC
Sbjct: 1305 CARGQCVDLRLRCDGEADCQDRSDEADC---DAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
Query: 3620 EDNSDE 3625
D SDE
Sbjct: 1362 IDGSDE 1367
Score = 217 bits (552), Expect = 2e-55
Identities = 109/324 (33%), Positives = 174/324 (53%), Gaps = 17/324 (5%)
Query: 3174 YICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNV---V 3230
Y C C G + +G+TC+ + E L+ + R LR +++D ++ I+ +D++ +
Sbjct: 319 YTCACPTGVQLQDNGRTCKAGA--EEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAI 376
Query: 3231 ALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDAR 3290
A+D+D +E +YW D + + I R +L+ + +T++N + + +AVDWV+R LYW D
Sbjct: 377 AIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTG 436
Query: 3291 LDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVG 3350
D + V+ LNG R++L +D PR +ALHP G +YW DWG I
Sbjct: 437 TDRIEVTRLNGTSRKILVSEDLD--------EPRAIALHPVMGLMYWTDWGENPKIECAN 488
Query: 3351 MDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHP 3410
+DG + V+++ L WPNG+ +D LYW DA IE +++G R T+ + LPH
Sbjct: 489 LDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHI 548
Query: 3411 FAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCG 3470
F T+ D IYWTDW R++E+ +K S R +++ + + + + +NPC
Sbjct: 549 FGFTLLGDFIYWTDWQRRSIERVHKVKAS-RDVIIDQLPDLMGLKAVN-VAKVVGTNPCA 606
Query: 3471 TNNGGCSHLCLIKPGGKGFTCECP 3494
NGGCSHLC P C CP
Sbjct: 607 DRNGGCSHLCFFTP--HATRCGCP 628
Score = 214 bits (544), Expect = 2e-54
Identities = 139/422 (32%), Positives = 198/422 (46%), Gaps = 65/422 (15%)
Query: 3107 KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK 3166
K G N C D + GC H C T + C C G +L+SD +TC+ +P
Sbjct: 598 KVVGTNPCADRN-GGCSHLCFFTPHATRCGCPIGLELLSDMKTCI-------VP------ 643
Query: 3167 CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID--GYFYSLILE 3224
E +L+F++R + ++++ ++ L
Sbjct: 644 -------------------------------EAFLVFTSRAAIHRISLETNNNDVAIPLT 672
Query: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKL 3284
G+ ALDFD +YW D + I R F+N ++ E ++ L E +AVDW+ + L
Sbjct: 673 GVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNL 732
Query: 3285 YWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA 3344
YW D + + V+ L+G R++L + DNPR LAL P GY+YW +WG +
Sbjct: 733 YWADTGTNRIEVARLDGQFRQVLVWRDL--------DNPRSLALDPTKGYIYWTEWGGKP 784
Query: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
I R MDGTN ++ K+ N +TIDY + LYW D IE S++ G R + D
Sbjct: 785 RIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD 843
Query: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPI 3464
LPHPF +T + D IYWTDWN ++E+ +K G NR + DI V+H RQ
Sbjct: 844 D-LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
Query: 3465 VSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEK 3524
+ N C NNG C LCL PG G C C + TL S S C P T FL + +
Sbjct: 903 L-NDCMHNNGQCGQLCLAIPG--GHRCGCASHY-TLDPS-SRNCSP---PTTFLLFSQKS 954
Query: 3525 CI 3526
I
Sbjct: 955 AI 956
Score = 200 bits (509), Expect = 2e-50
Identities = 128/377 (33%), Positives = 195/377 (51%), Gaps = 34/377 (9%)
Query: 3996 ETNVFDRTSCLDINECEQFGTCPQHCRNTKGS--YECVCADGFTSMSDRPGKRCAAEGSS 4053
E F T C + N G C C + Y C C G + G+ C A G+
Sbjct: 290 ERQPFFHTRCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDN--GRTCKA-GAE 341
Query: 4054 PLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRF 4112
+LLL +R+ +L + F++ LQ ++ A+ D+DP + VY+T
Sbjct: 342 EVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLE---GYVYWT----DDEV 394
Query: 4113 GAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLD 4172
AI+RAY+ SG LV + PDGIAVDWV R++YW+D RIEV +L+
Sbjct: 395 RAIRRAYLDG--SGAQTLVNTE------INDPDGIAVDWVARNLYWTDTGTDRIEVTRLN 446
Query: 4173 GRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPT 4232
G RK L+S DLD+P AIA++P +GLM+WTDWG+ PKIE A ++G++R +LV LGWP
Sbjct: 447 GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPN 506
Query: 4233 GLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEK 4291
GL++D L ++YW D K D IE I DGT RR + ++ + + + + D +YW ++
Sbjct: 507 GLALD-LQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQR 565
Query: 4292 GEVWKQNKFGQGKKEKTLVVN--PWLTQVRIFHQLRYNKSVPNLCKQ-ICSHLCLLRPGG 4348
+ + +K K + ++++ P L ++ + + + P + CSHLC P
Sbjct: 566 RSIERVHKV---KASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHA 622
Query: 4349 YSCACPQGSSFIEGSTT 4365
C CP G + T
Sbjct: 623 TRCGCPIGLELLSDMKT 639
Score = 178 bits (452), Expect = 1e-43
Identities = 116/333 (34%), Positives = 169/333 (50%), Gaps = 26/333 (7%)
Query: 4048 AAEGSSPLLLLPDNVRIRKYNLSSERFSEYL--QDEEYIQAVDYDWDPKDIGLSVVYYTV 4105
A +SPLLL + +R + + + E AVD+ + VY+T
Sbjct: 27 APAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSK-----GAVYWTD 81
Query: 4106 RGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKR 4165
E AIK+ Y+ + N+V + ++ PDG+A DWVG+ +YW+D + R
Sbjct: 82 VSEE----AIKQTYLNQTGAAVQNVV------ISGLVSPDGLACDWVGKKLYWTDSETNR 131
Query: 4166 IEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVF 4225
IEVA L+G RK L DLDQP AIA++P G M+WTDWG+ P+IE A M+G R I+V
Sbjct: 132 IEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVD 191
Query: 4226 EDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDR-RVIAKEAMNPYSLDIFEDQL 4284
D+ WP GL+ID L ++YW+D K I DG+ R +V+ +P++L + D L
Sbjct: 192 SDIYWPNGLTID-LEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTL 250
Query: 4285 YWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHL 4341
YW + + NK GK+++ L +++ Q R C++ CSHL
Sbjct: 251 YWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQER-QPFFHTRCEEDNGGCSHL 309
Query: 4342 CLLRPGG--YSCACPQGSSFIEGSTTECDAAIE 4372
CLL P Y+CACP G + T C A E
Sbjct: 310 CLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAE 341
Score = 155 bits (391), Expect = 1e-36
Identities = 87/274 (31%), Positives = 143/274 (52%), Gaps = 9/274 (3%)
Query: 746 IDFDAQDSTIFFSDMSKHMIFKQKIDGTGREI--LAANRVENVESLAFDWISKNLYWTDS 803
+DF ++++D+S+ I + ++ TG + + + + + + LA DW+ K LYWTDS
Sbjct: 68 VDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDS 127
Query: 804 HYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLL 862
I V L +R+ + Q L+ PR++ + P GY+++TDW +I RA DGS
Sbjct: 128 ETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRK 187
Query: 863 PVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIF 922
++++ + WPNGL ID +LYW DA I + DG R+++ +THPF L +
Sbjct: 188 IIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVE-GSLTHPFALTLS 246
Query: 923 GEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNA-CNQPTHPN 981
G+ L++TDW+ +I K GG+ I S + + ++ Q + C + N
Sbjct: 247 GDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEED---N 303
Query: 982 GDCSHFCFPVPNFQ-RVCGCPYGMRLASNHLTCE 1014
G CSH C P+ C CP G++L N TC+
Sbjct: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK 337
Score = 151 bits (381), Expect = 2e-35
Identities = 103/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
N C ++ G C C T + C C G +SD K C + L+ I +
Sbjct: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDM--KTCIVPEA--FLVFTSRAAIHRI 658
Query: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
+L + + +A D+D + + +Y+T I RA++
Sbjct: 659 SLETNNNDVAIPLTGVKEASALDFD---VSNNHIYWT----DVSLKTISRAFMNG----- 706
Query: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
+++ V+ L Y P+G+AVDW+G+++YW+D RIEVA+LDG++R+ L+ DLD P
Sbjct: 707 SSVEHVVEFGLDY---PEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNP 763
Query: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
++A++P G ++WT+WG +P+I A+M+G + LV + +G L+IDY + R+YW+
Sbjct: 764 RSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYA-DQRLYWT 821
Query: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307
D ++IE+ G +R VIA + +P+ L + D +YW + + +K + +
Sbjct: 822 DLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADK--TSGRNR 879
Query: 4308 TLVVN--PWLTQVRIFHQLR---YNKSVPNLCKQICSHLCLLRPGGYSCAC 4353
TL+ ++ + +FH R N + N C LCL PGG+ C C
Sbjct: 880 TLIQGHLDFVMDILVFHSSRQDGLNDCMHN--NGQCGQLCLAIPGGHRCGC 928
Score = 109 bits (272), Expect = 7e-23
Identities = 57/148 (38%), Positives = 75/148 (50%), Gaps = 18/148 (12%)
Query: 1094 DGSDEHNCPTHA-----------PASCLDTQYTCDNHQ--CISKNWVCDTDNDCGDGSDE 1140
DG+ +CP H P +C Q+ C + CI W CD +C D SDE
Sbjct: 1233 DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE 1292
Query: 1141 KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC 1200
+ C C +QF C +C+DL CDG+ DC D SDE C C +QF+CASG +C
Sbjct: 1293 EGC---PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASG-QC 1348
Query: 1201 IGVTNRCDGVFDCSDNSDEAGCP-TRPP 1227
+ + +CD DC D SDE C T+PP
Sbjct: 1349 VLIKQQCDSFPDCIDGSDELMCEITKPP 1376
Score = 109 bits (272), Expect = 7e-23
Identities = 48/113 (42%), Positives = 63/113 (55%), Gaps = 2/113 (1%)
Query: 107 TCSSHQITCSNGQ--CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKC 164
TCS Q C+ G+ CIP +RCD +C D +DE C + Q C G C + +C
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRC 1317
Query: 165 DWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
D + DC+D SDE +C ICL N+F C +G+C+ CD DC DGSDE C
Sbjct: 1318 DGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 105 bits (263), Expect = 8e-22
Identities = 54/125 (43%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 3715 EERTCHPVGDFRCKNHH--CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCI 3772
E TC P F C CIP W+CDG +C D SDEE C C+ ++F C QC+
Sbjct: 1255 EPPTCSP-DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCV 1311
Query: 3773 PSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
R CD DC D SDE DC+ C P F+C SG CV + +CD DC+D SDE C
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 3833 PTRFP 3837
P
Sbjct: 1371 EITKP 1375
Score = 103 bits (258), Expect = 3e-21
Identities = 56/138 (40%), Positives = 73/138 (52%), Gaps = 10/138 (7%)
Query: 8 VACTLLLALVACLAPASGQECDSAHFRCGSGH--CIPADWRCDGTKDCSDDADEIGCAVV 65
V LL L+ C P + C F C +G CIP WRCDG +C D +DE GC V
Sbjct: 1242 VHLVLLQNLLTCGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV- 1297
Query: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEY 125
C F C + GQC+ CD + DC D SDE DC + C +Q C++GQC+ +
Sbjct: 1298 -CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDE-ADC-DAICLPNQFRCASGQCVLIKQ 1353
Query: 126 RCDHVRDCPDGADENDCQ 143
+CD DC DG+DE C+
Sbjct: 1354 QCDSFPDCIDGSDELMCE 1371
Score = 102 bits (254), Expect = 9e-21
Identities = 50/120 (41%), Positives = 60/120 (50%), Gaps = 10/120 (8%)
Query: 3756 PRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHS 3813
P C+ +F C + CIP W CD + +C D SDE C + C F C G CV
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDL 1313
Query: 3814 ELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE 3873
L+CDG ADC D SDEADC A C F C + C+ +CD DC DGSDE
Sbjct: 1314 RLRCDGEADCQDRSDEADC------DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 100 bits (248), Expect = 4e-20
Identities = 48/124 (38%), Positives = 67/124 (54%), Gaps = 9/124 (7%)
Query: 2992 TCSENEFTCGYGL--CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTF 3049
TCS ++F C G CIP +RCD +C D SDE GC C QF C G+C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDLRL 1315
Query: 3050 VCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
CD + DC D SDE + C P++F+C +G+C+ + + C+ DC+D SDE C
Sbjct: 1316 RCDGEADCQDRSDEA-----DCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Query: 3110 GINE 3113
I +
Sbjct: 1371 EITK 1374
Score = 95.1 bits (235), Expect = 1e-18
Identities = 55/157 (35%), Positives = 75/157 (47%), Gaps = 20/157 (12%)
Query: 153 DNGACYNT-------SQKCDWKVDCRDSSDEINCTE--ICLHNEFSCGNGE--CIPRAYV 201
DNG C + + +C V + + C E C ++F+C GE CIP A+
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
Query: 202 CDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPH 261
CD +C D SDE C P C QF C G+C+ CDGE DC+D DE C++
Sbjct: 1280 CDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA--- 1334
Query: 262 DVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
C P ++ C SG+C+ I + CD DC DE
Sbjct: 1335 ---ICLPNQFRC-ASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 94.4 bits (233), Expect = 2e-18
Identities = 50/117 (42%), Positives = 61/117 (52%), Gaps = 7/117 (5%)
Query: 66 TCQQGYFKCQS-EGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSE 124
TC F C + E CIP +W CD +CDD SDE + C CS+ Q C+ GQC+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE-EGCP--VCSAAQFPCARGQCVDLR 1314
Query: 125 YRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC 179
RCD DC D +DE DC C Q C +G C Q+CD DC D SDE+ C
Sbjct: 1315 LRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 92.4 bits (228), Expect = 9e-18
Identities = 49/132 (37%), Positives = 64/132 (48%), Gaps = 13/132 (9%)
Query: 3794 EMRTCHPEYFQCTSGH--CVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKN 3851
E TC P+ F C +G C+ +CDG +C D SDE CP C A F C
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-------CSAAQFPCAR 1307
Query: 3852 HVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGD 3911
C+ +CDG+ DC D SDE D C PN+FRC + +C+ + C+ DC D
Sbjct: 1308 GQCVDLRLRCDGEADCQDRSDEA---DCDAIC-LPNQFRCASGQCVLIKQQCDSFPDCID 1363
Query: 3912 GTDETEEHCRKP 3923
G+DE KP
Sbjct: 1364 GSDELMCEITKP 1375
Score = 88.2 bits (217), Expect = 2e-16
Identities = 51/123 (41%), Positives = 65/123 (52%), Gaps = 12/123 (9%)
Query: 3634 TCRPGQFRCANGR--CIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691
TC P QF CA G CIP AW+CD +C D SDE E C +C + +F C +
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC----PVC-SAAQFPCARG-Q 1309
Query: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
C+ C+G DC+D SDE C + C P FRC + C+ ++ QCD DC D SDE
Sbjct: 1310 CVDLRLRCDGEADCQDRSDEADC-DAICLP-NQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Query: 3752 ENC 3754
C
Sbjct: 1368 LMC 1370
Score = 87.0 bits (214), Expect = 4e-16
Identities = 47/118 (39%), Positives = 61/118 (51%), Gaps = 9/118 (7%)
Query: 2821 TCQSGYTKCHNSNI-CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQ 2879
TC C I CIP + CDG +C D SDE CS+++F CA G+C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDL 1313
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
CD E DC D SDE A C + CL ++F+C G+C+ + CD DC D SDE
Sbjct: 1314 RLRCDGEADCQDRSDE-ADC---DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 86.7 bits (213), Expect = 5e-16
Identities = 84/357 (23%), Positives = 148/357 (41%), Gaps = 28/357 (7%)
Query: 4008 INEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRK 4066
+N+C G C Q C G + C CA +T D + C+ + LL I +
Sbjct: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTL--DPSSRNCSPP--TTFLLFSQKSAISR 958
Query: 4067 YNLSSERFSEY---LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNF 4123
+ + L ++A+DYD L Y V G + IKRA
Sbjct: 959 MIPDDQHSPDLILPLHGLRNVKAIDYD------PLDKFIYWVDGRQN----IKRA---KD 1005
Query: 4124 ESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTD 4183
+ + ++ + QP +++D R ++W+ I V +L G ++ D
Sbjct: 1006 DGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGD 1065
Query: 4184 LDQPAAIAVNPKLGLMFWTDW-GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNND 4242
D+P AI VN + G +++T+ + KIE A ++G +R +L L P L +D
Sbjct: 1066 RDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDN-TLG 1124
Query: 4243 RIYWSDFKEDVIETIKYDGTDRRVIA-KEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFG 4301
+++W D IE+ G +R + + P L I LYWI +++ + + K
Sbjct: 1125 KLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTT 1184
Query: 4302 QGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGY-SCACP 4354
K+ + LT + ++ + + C + CSH+C+ + G C+CP
Sbjct: 1185 GDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Score = 85.9 bits (211), Expect = 9e-16
Identities = 50/124 (40%), Positives = 59/124 (47%), Gaps = 18/124 (14%)
Query: 1227 PGMCHSDEFQCQEDGI-CIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
P C D+F C I CIP W CDG P+C SDE V C ++ F C G C+
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQFPCARGQCVD 1312
Query: 1286 RAWLCDRDNDCGDMSDEKDC-----PTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPN 1340
CD + DC D SDE DC P Q FRC S Q CV + CD DC +
Sbjct: 1313 LRLRCDGEADCQDRSDEADCDAICLPNQ-FRCASGQ--------CVLIKQQCDSFPDCID 1363
Query: 1341 GTDE 1344
G+DE
Sbjct: 1364 GSDE 1367
Score = 85.1 bits (209), Expect = 1e-15
Identities = 46/117 (39%), Positives = 58/117 (49%), Gaps = 6/117 (5%)
Query: 145 PTC--EQLTCDNGA--CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAY 200
PTC +Q C G C + +CD +C D SDE C +C +F C G+C+
Sbjct: 1257 PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP-VCSAAQFPCARGQCVDLRL 1315
Query: 201 VCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCE 257
CD + DCQD SDE C+ C QF C SG+C+ CD DC D DE CE
Sbjct: 1316 RCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE 1371
Score = 82.4 bits (202), Expect = 1e-14
Identities = 48/120 (40%), Positives = 59/120 (49%), Gaps = 9/120 (7%)
Query: 1187 CTASQFKCASGD-KCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIP 1245
C+ QF CA+G+ CI RCDG +C D SDE GCP +C + +F C G C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP-----VCSAAQFPCAR-GQCVD 1312
Query: 1246 NFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
CDG DC SDE A C + F C +G C+ CD DC D SDE C
Sbjct: 1313 LRLRCDGEADCQDRSDE--ADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 80.1 bits (196), Expect = 5e-14
Identities = 50/132 (37%), Positives = 63/132 (47%), Gaps = 15/132 (11%)
Query: 2898 SCGHSERTCLADEFKCDGGR--CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLC 2955
+CG TC D+F C G CIP W CDG +C D SDE+ C CS ++F C
Sbjct: 1252 TCGEPP-TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE---GC--PVCSAAQFPC 1305
Query: 2956 VNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRH 3015
+C+ CDG+ DC D DE +C C N+F C G C+ +CD
Sbjct: 1306 ARG-----QCVDLRLRCDGEADCQDRSDE-ADCD-AICLPNQFRCASGQCVLIKQQCDSF 1358
Query: 3016 NDCGDYSDERGC 3027
DC D SDE C
Sbjct: 1359 PDCIDGSDELMC 1370
Score = 79.7 bits (195), Expect = 6e-14
Identities = 44/127 (34%), Positives = 61/127 (48%), Gaps = 19/127 (14%)
Query: 3594 CDSNEWQCANKR--CIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQA 3651
C +++ CA CIP +W+CD F +C+D SDE+ C QF CA G+C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCARGQCVDLR 1314
Query: 3652 WKCDVDNDCGDHSDEPIEECMSSAHLCDNF---TEFSCKTNYRCIPKWAVCNGVDDCRDN 3708
+CD + DC D SDE CD +F C + +C+ C+ DC D
Sbjct: 1315 LRCDGEADCQDRSDEAD---------CDAICLPNQFRCASG-QCVLIKQQCDSFPDCIDG 1364
Query: 3709 SDEQGCE 3715
SDE CE
Sbjct: 1365 SDELMCE 1371
Score = 76.6 bits (187), Expect = 5e-13
Identities = 44/130 (33%), Positives = 58/130 (44%), Gaps = 16/130 (12%)
Query: 3833 PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD 3892
PT PD C +C IP W+CDG +C D SDEE P S +F C
Sbjct: 1257 PTCSPDQFACATGEIDC-----IPGAWRCDGFPECDDQSDEE-----GCPVCSAAQFPCA 1306
Query: 3893 NNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADD 3952
+C+ C+G DC D +DE + C +++C +G C+ CD D
Sbjct: 1307 RGQCVDLRLRCDGEADCQDRSDEAD------CDAICLPNQFRCASGQCVLIKQQCDSFPD 1360
Query: 3953 CGDWSDELGC 3962
C D SDEL C
Sbjct: 1361 CIDGSDELMC 1370
Score = 62.0 bits (149), Expect = 1e-08
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 10/98 (10%)
Query: 1268 PKTCPSSYFHCDNG--NCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNIC 1325
P TC F C G +CI AW CD +C D SDE+ CP C + Q+ C C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPC-ARGQC 1310
Query: 1326 VNLSVVCDGIFDCPNGTDES---PLCNGNSCSDFNGGC 1360
V+L + CDG DC + +DE+ +C N +G C
Sbjct: 1311 VDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQC 1348
Score = 53.5 bits (127), Expect = 5e-06
Identities = 42/141 (29%), Positives = 58/141 (41%), Gaps = 22/141 (15%)
Query: 3851 NHVCIPPYWKCDGDDDCGDGSD----EELHLCLDVPCNSPNRFRCDNNR--CIYSHEVCN 3904
+H+CI K DG C + L C + P SP++F C CI C+
Sbjct: 1225 SHICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCD 1281
Query: 3905 GVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
G +C D +DE E C C+ ++ C G C+ CD DC D SDE C+
Sbjct: 1282 GFPECDDQSDE--EGC-----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA 1334
Query: 3965 ---GKERTCAENIC---EQNC 3979
+ CA C +Q C
Sbjct: 1335 ICLPNQFRCASGQCVLIKQQC 1355
Score = 39.7 bits (91), Expect = 0.071
Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 4/50 (8%)
Query: 19 CLAPASGQECDSA----HFRCGSGHCIPADWRCDGTKDCSDDADEIGCAV 64
C + +CD+ FRC SG C+ +CD DC D +DE+ C +
Sbjct: 1323 CQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
Score = 39.3 bits (90), Expect = 0.092
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 11/92 (11%)
Query: 1349 NGNSCSDFNGGCTHECVQEPFGA-KCLCPLGFLLANDSKTCEDIDEC--DILGSCSQHCY 1405
+ + C+ NGGC+H C+ + G +C CP+ +L + TC + C D +
Sbjct: 1213 SAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEID 1272
Query: 1406 NMRGSFRC----SCDTGYMLESDGRTCKVTAS 1433
+ G++RC CD +SD C V ++
Sbjct: 1273 CIPGAWRCDGFPECDD----QSDEEGCPVCSA 1300
Score = 39.3 bits (90), Expect = 0.092
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 9/99 (9%)
Query: 3068 CHTPEPTCPPHEFKCDNGR--CIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHN 3125
C P PTC P +F C G CI C+ +C D SDE+GC + C
Sbjct: 1253 CGEP-PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQ 1309
Query: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCS 3164
C D C + SD+ C I C F C+
Sbjct: 1310 CVD--LRLRCDGEADCQDRSDEADCDAI--CLPNQFRCA 1344
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 521 bits (1342), Expect = e-147
Identities = 286/733 (39%), Positives = 391/733 (53%), Gaps = 47/733 (6%)
Query: 2784 TEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCD 2843
++F C N RCI + C+G ++C D SDEKNC +TC C+N C+P + CD
Sbjct: 36 SQFQCTNGRCITLLWKCDGDEDCVDG--SDEKNCVKKTCAESDFVCNNGQ-CVPSRWKCD 92
Query: 2844 GDNDCGDNSDENPTYCTTHTCSSSEFQCA--SGRCIPQHWYCDQETDCFDASDEPASCGH 2901
GD DC D SDE+P C TC E C S +CIP W CD E DC D+ ++ +CG+
Sbjct: 93 GDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDEENCGN 151
Query: 2902 SERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPP 2961
TC DEF C GRCI ++C+G +DC D SDE C C EF C
Sbjct: 152 I--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE---LDCAPPTCGAHEFQCSTSS-- 204
Query: 2962 DRRCIPQSWVCDGDVDCTDGYDEN-QNCTRRT-----CSENEFTCGYGLCIPKIFRCDRH 3015
CIP SWVCD D DC+D DE+ + C R+ C +E CG G CI K +RCD
Sbjct: 205 ---CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGD 261
Query: 3016 NDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
DC D SDE C +TC+ +QF C++G CI + C+ DC DGSDE+ C
Sbjct: 262 PDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVN--CKNVNQCL 319
Query: 3076 PPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE--KGCGINECHDPSISGCDHNCTDTLTSF 3133
P +FKC +G CI++ K+CN DC D SDE K C INEC + GC H C D + +
Sbjct: 320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGY 378
Query: 3134 YCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQ 3193
C C G++L+ D++TC DIDEC + P +CSQ C N+ G Y C+C+ GY + C+
Sbjct: 379 ECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA 436
Query: 3194 NSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWID-TQRQVIE 3252
EP LIF+NR +R + ++ Y ++E L N VALD D ++L+W D +Q+ +
Sbjct: 437 VGK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFS 495
Query: 3253 RMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCV 3312
+K + + + ++AVDWV + +YW DA + V+ L+G R+ L +
Sbjct: 496 ASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDL 555
Query: 3313 DANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
P +A+ P G++YW+DWG A I + GM+G ++ +++ ++WPNGIT+
Sbjct: 556 R--------EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
Query: 3373 DYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTV 3430
D LYW D+ L + DL G R V L HP A+TIFED +YW D V
Sbjct: 608 DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
Query: 3431 EKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPC--GTNNGGCSHLCL----IKP 3484
NK+ GS TLVN + DI VYH QP N C NGGC +LCL I
Sbjct: 668 YGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIND 727
Query: 3485 GGKGFTCECPDDF 3497
+TC CP +
Sbjct: 728 HSPKYTCSCPSGY 740
Score = 505 bits (1301), Expect = e-142
Identities = 283/747 (37%), Positives = 396/747 (53%), Gaps = 34/747 (4%)
Query: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
E T +C F C NGRC+ + CDG +DC D SDE+ C + TC+ S F
Sbjct: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFV 78
Query: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH--QCISKNWVCDTD 1131
C +G+C+P+ W+CD DC DGSDE H +C + +C H QCI +W CD +
Sbjct: 79 CNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM-RTCRIHEISCGAHSTQCIPVSWRCDGE 137
Query: 1132 NDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL-NCTAS 1190
NDC G DE+NC + TC P +F C + RCI +FVC+G DC DGSDE+ C C A
Sbjct: 138 NDCDSGEDEENCGNI-TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH 196
Query: 1191 QFKCASGDKCIGVTNRCDGVFDCSDNSDEA--GCPTRPP--GMCHSDEFQCQEDGICIPN 1246
+F+C++ CI ++ CD DCSD SDE+ C +P C + E QC G CI
Sbjct: 197 EFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS-GECIHK 254
Query: 1247 FWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
W CDG PDC GSDE N C +TC F C++G+CIH + C+ DC D SDE +C
Sbjct: 255 KWRCDGDPDCKDGSDEVN-CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
Query: 1307 TQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--CNGNSCSDFNGGCTHEC 1364
+++C C+++S VC+ DC + +DE PL C+ N C NGGC+H C
Sbjct: 314 NVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDE-PLKECHINECLVNNGGCSHIC 371
Query: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424
G +C C GF L D KTC DIDEC G CSQ C N++G ++C C GY ++
Sbjct: 372 KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLA 430
Query: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
CK E L+ N+ + + LVE VA+D D + ++FW+D
Sbjct: 431 TGVCKAVGKEPSLIFT---NRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
Query: 1485 ATQGKTWSA-FQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
+Q +SA + R V ++ IA+DWV + +YWTD A +TI V+ +DG+ R
Sbjct: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Query: 1544 TVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGL 1603
L + +L P +A+DP ++WSDWG +IE+A M+G R +V I WP G+
Sbjct: 548 KFLFNSDLREPASIAVDPLSG--FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGI 605
Query: 1604 TIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATR 1663
T+D LY++DS L + D NG RR V+ S + HP ALT+FED VYW D
Sbjct: 606 TLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENE 665
Query: 1664 RVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCL----L 1715
V ANK+ G + ++ N+ I+ H QP+ N C C +LCL +
Sbjct: 666 AVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQI 725
Query: 1716 SSQGPHFYSCVCPSGWSLSPDLLNCLR 1742
+ P Y+C CPSG+++ + +C R
Sbjct: 726 NDHSPK-YTCSCPSGYNVEENGRDCQR 751
Score = 482 bits (1241), Expect = e-135
Identities = 283/764 (37%), Positives = 399/764 (52%), Gaps = 78/764 (10%)
Query: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIP 3694
C P QF+C NGRCI WKCD D DC D SDE + C+ C ++F C N +C+P
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNCVKKT--CAE-SDFVCN-NGQCVP 86
Query: 3695 KWAVCNGVDDCRDNSDE--QGCEERTCHPVGDFRCKNH--HCIPLRWQCDGQNDCGDNSD 3750
C+G DC D SDE + C RTC + + C H CIP+ W+CDG+NDC D
Sbjct: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCR-IHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 3751 EENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHC 3810
EENC C+ EF C + +CI ++C+ +DC D SDE DC TC FQC++ C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSC 205
Query: 3811 VHSELKCDGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCG 3868
+ CD ADC D SDE+ C + C A+ +C + CI W+CDGD DC
Sbjct: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
Query: 3869 DGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETE----EHCRKPT 3924
DGSDE C C P++F C++ CI+ CNG+ DC DG+DE C P
Sbjct: 266 DGSDEVN--CPSRTCR-PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
Query: 3925 PKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQN---CTQ 3981
++KC +G CI VC+ DC DWSDE + C N C N C+
Sbjct: 323 -------KFKCRSGECIDISKVCNQEQDCRDWSDE------PLKECHINECLVNNGGCSH 369
Query: 3982 LNEG---GFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTS 4038
+ + G+ C C AGFE + DR +C DI+EC+ G C Q C N KG Y+C C+ G+
Sbjct: 370 ICKDLVIGYECDCAAGFE--LIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGY-- 425
Query: 4039 MSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGL 4098
D C A G P L+ + IRK L + + + ++ A+D DI
Sbjct: 426 QMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD-----ADIAA 480
Query: 4099 SVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYW 4158
+++ + + F A + + V+ +D V P IAVDWV + IYW
Sbjct: 481 QKLFWADLSQKAIFSA-------SIDDKVGRHVKMID----NVYNPAAIAVDWVYKTIYW 529
Query: 4159 SDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGE 4218
+D +K I VA LDG RK+L ++DL +PA+IAV+P G ++W+DWG+ KIE A MNG
Sbjct: 530 TDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGF 589
Query: 4219 DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKE---AMNPY 4275
DR LV D+ WP G+++D + + R+YW D K ++ ++ +G DRR++ K +P
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKS-RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPL 648
Query: 4276 SLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQ-VRIFHQLRYNKSVPNLC 4334
+L IFED++YWI E V+ NKF G + TLV N Q + ++H+L S N C
Sbjct: 649 ALTIFEDRVYWIDGENEAVYGANKF-TGSELATLVNNLNDAQDIIVYHEL-VQPSGKNWC 706
Query: 4335 KQI-----CSHLCLLRP------GGYSCACPQGSSFIEGSTTEC 4367
++ C +LCL P Y+C+CP G + +E + +C
Sbjct: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYN-VEENGRDC 749
Score = 454 bits (1169), Expect = e-127
Identities = 264/760 (34%), Positives = 381/760 (50%), Gaps = 86/760 (11%)
Query: 12 LLLALVACLAP----ASGQ----ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63
L L L C AP A+G +C+ + F+C +G CI W+CDG +DC D +DE C
Sbjct: 9 LWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
Query: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER-QDCSQSTCSSHQITCS--NGQC 120
TC + F C + GQC+P+ W CD D DC+DGSDE + C TC H+I+C + QC
Sbjct: 69 KKTCAESDFVCNN-GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQC 127
Query: 121 IPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEIN 178
IP +RCD DC G DE +C TC ++ TC +G C + + C+ + DC D SDE++
Sbjct: 128 IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
Query: 179 CTE-ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACN-----YPTCGGYQFTCP 230
C C +EF C CIP ++VCD D DC D SDE C + C + C
Sbjct: 188 CAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 231 SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGIL 290
SG CI++ W CDG+ DCKD DE C S C P ++ C E G CI + C+GI
Sbjct: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPS-----RTCRPDQFEC-EDGSCIHGSRQCNGIR 301
Query: 291 DCPGREDENNTST-------GKY------------------------------CSMTLCS 313
DC DE N GK+ C + C
Sbjct: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
Query: 314 ALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLC 371
N C + C + G C C G+ + D +TC + D+CQ GIC Q C + G + C
Sbjct: 362 VNNGGCSHICKDLVIGYECDCAAGFELI--DRKTCGDIDECQNPGICSQICINLKGGYKC 419
Query: 372 HCEEGYILERGQ-YCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVA 430
C GY ++ CKA E S+IF+N RD+ + + + LVE VA+
Sbjct: 420 ECSRGYQMDLATGVCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDAD 477
Query: 431 FHYHLQRVFWTDTVQNKVFSVDIN---GLNIQEVLNVSVETPENLAVDWVNNKIYLVETK 487
Q++FW D Q +FS I+ G +++ + NV P +AVDWV IY +
Sbjct: 478 IA--AQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVY--NPAAIAVDWVYKTIYWTDAA 533
Query: 488 VNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEP-KLERAFMDGS 546
I + LDG+ R L +L P IAVDP G++++SDW GEP K+E+A M+G
Sbjct: 534 SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW----GEPAKIEKAGMNGF 589
Query: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
+R+ LV + WP G+TLD+I R+YW+DS+ + +V +G R+ V+ + HP
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
Query: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
+++FE +V++ D AV ANKFT + + VYH L QP N C+++
Sbjct: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
Query: 667 --NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
NGGCE +C+ + + ++ + C C G+ ++ + R C
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 243 bits (621), Expect = 2e-63
Identities = 145/416 (34%), Positives = 205/416 (49%), Gaps = 36/416 (8%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C +QF C N +CI + WKCDG +DC DGSDE C ++ C F C++G C +
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRWK 90
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA--NKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ +C DGSDE C C +E C + +CIP SW+CD NDC+ S ED +
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD--SGEDEEN 148
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTN 3689
C + TC P +F C++GRCI + + C+ +DC D SDE + A EF C T+
Sbjct: 149 CGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE-----LDCAPPTCGAHEFQCSTS 203
Query: 3690 YRCIPKWAVCNGVDDCRDNSDE--QGCEER----TCHPVGDFRCKNHHCIPLRWQCDGQN 3743
CIP VC+ DC D SDE + C + T P + +C + CI +W+CDG
Sbjct: 204 -SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDP 262
Query: 3744 DCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE-MRTC-HPE 3801
DC D SDE NC R C +F C + CI C+ DC D SDE +C+ + C P
Sbjct: 263 DCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
Query: 3802 YFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVC--IPPYW 3859
F+C SG C+ C+ DC D SDE P + C C +H+C + +
Sbjct: 323 KFKCRSGECIDISKVCNQEQDCRDWSDE---PLKECHINECLVNNGGC-SHICKDLVIGY 378
Query: 3860 KCD--------GDDDCGDGSD-EELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGV 3906
+CD CGD + + +C + N ++C+ +R Y ++ GV
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG-YQMDLATGV 433
Score = 234 bits (596), Expect = 2e-60
Identities = 134/350 (38%), Positives = 181/350 (51%), Gaps = 31/350 (8%)
Query: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESV 2735
+C + + ++ K+C+ + C S F C+NG+C+ WKCD D DC DGSDE
Sbjct: 51 KCDGDEDCVDGSDEKNCVK---KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQ 107
Query: 2736 CALHTCSPTAFTCA--NGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRC 2793
C + TC +C + +C+ S+RCD NDC G DE C C + EF C++ RC
Sbjct: 108 CHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITC-SPDEFTCSSGRC 166
Query: 2794 IPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSD 2853
I R F+CNG D+C D SDE +C TC + +C S+ CIP ++CD D DC D SD
Sbjct: 167 ISRNFVCNGQDDCSDG--SDELDCAPPTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSD 223
Query: 2854 ENPTYC----TTHT-CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLA 2908
E+ C HT C +SE QC SG CI + W CD + DC D SDE +C RTC
Sbjct: 224 ESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE-VNC--PSRTCRP 280
Query: 2909 DEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQN--CSDSEFLCVNDRPPDRRCI 2966
D+F+C+ G CI C+G DC D SDE C+N N +F C + CI
Sbjct: 281 DQFECEDGSCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSG-----ECI 332
Query: 2967 PQSWVCDGDVDCTDGYDEN-QNCTRRTCSENEFTCGYGLCIPKI--FRCD 3013
S VC+ + DC D DE + C C N C + +C + + CD
Sbjct: 333 DISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECD 381
Score = 218 bits (555), Expect = 1e-55
Identities = 124/342 (36%), Positives = 169/342 (49%), Gaps = 20/342 (5%)
Query: 3492 ECPDDFRTLQLSGSTYCMPM-CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCP 3549
+C D + S C+ C+ + F+C NN +C+P WKCDG DC DGSDE C
Sbjct: 51 KCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCH 109
Query: 3550 QRFCRLGQFQCS--DGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCI 3607
R CR+ + C C C+ +C G DE+ C N C +E+ C++ RCI
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN--CGNITCSPDEFTCSSGRCI 167
Query: 3608 PESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEP 3667
++ C+ +DC D SDE CA TC +F+C+ CIP +W CD D DC D SDE
Sbjct: 168 SRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDES 225
Query: 3668 IEEC--MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDF 3725
+E+C H +E C + CI K C+G DC+D SDE C RTC P F
Sbjct: 226 LEQCGRQPVIHTKCPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRP-DQF 283
Query: 3726 RCKNHHCIPLRWQCDGQNDCGDNSDEENCA-PRECT-ESEFRCVNQQCIPSRWICDHYND 3783
C++ CI QC+G DC D SDE NC +C +F+C + +CI +C+ D
Sbjct: 284 ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQD 343
Query: 3784 CGDNSDERDCEMRTCHPEYFQCTSGHCVH--SELKCDGSADC 3823
C D SDE ++ CH +G C H +L DC
Sbjct: 344 CRDWSDE---PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
Score = 189 bits (481), Expect = 4e-47
Identities = 118/308 (38%), Positives = 150/308 (48%), Gaps = 31/308 (10%)
Query: 3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKC 3817
+C S+F+C N +CI W CD DC D SDE++C +TC F C +G CV S KC
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
Query: 3818 DGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNH--VCIPPYWKCDGDDDCGDGSDE 3873
DG DC D SDE+ C R C+ C H CIP W+CDG++DC G DE
Sbjct: 92 DGDPDCEDGSDESPEQCHMR-----TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
Query: 3874 ELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEY 3933
E C ++ C SP+ F C + RCI + VCNG DDC DG+DE + C PT C +E+
Sbjct: 147 E--NCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPT---CGAHEF 198
Query: 3934 KCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFI----- 3988
+C CIP VCDD DC D SDE G++ C + Q G I
Sbjct: 199 QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ-PVIHTKCPASEIQCGSGECIHKKWR 257
Query: 3989 C----SCTAGF-ETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRP 4043
C C G E N RT D ECE G+C R G +CV DG ++ +
Sbjct: 258 CDGDPDCKDGSDEVNCPSRTCRPDQFECED-GSCIHGSRQCNGIRDCV--DGSDEVNCKN 314
Query: 4044 GKRCAAEG 4051
+C G
Sbjct: 315 VNQCLGPG 322
Score = 178 bits (452), Expect = 1e-43
Identities = 110/361 (30%), Positives = 178/361 (49%), Gaps = 24/361 (6%)
Query: 666 NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723
N G C Q+C+ N G++C+C+ G+Q+D C AV + LIF+++ IR I
Sbjct: 402 NPGICSQICI------NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
Query: 724 FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANR 782
++ + V +D D +F++D+S+ IF ID GR + +
Sbjct: 456 LERKEYIQLVEQLRNT----VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN 511
Query: 783 VENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYL 840
V N ++A DW+ K +YWTD+ K+ISV L D T+R + L P S+ V P +G++
Sbjct: 512 VYNPAAIAVDWVYKTIYWTDAASKTISVATL-DGTKRKFLFNSDLREPASIAVDPLSGFV 570
Query: 841 FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900
+++DW PAKI +A +G P++ + WPNG+ +D SRLYW+D+ + +
Sbjct: 571 YWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630
Query: 901 GLDRR-RLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILH 959
G DRR L +E + HP L IF + +++ D A+ K G E+ + + +
Sbjct: 631 GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD 690
Query: 960 LKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013
+ Y +Q +G N C + NG C + C P P + C CP G + N C
Sbjct: 691 IIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Query: 1014 E 1014
+
Sbjct: 750 Q 750
Score = 163 bits (413), Expect = 3e-39
Identities = 108/407 (26%), Positives = 183/407 (44%), Gaps = 65/407 (15%)
Query: 2340 EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNC----------------- 2382
E + N CL NNGGCSH+C L + +CDCA G D K C
Sbjct: 354 ECHINECLVNNGGCSHICKDL--VIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICI 411
Query: 2383 ------------------------AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
A+ E LIF +R + L+ + + Q +
Sbjct: 412 NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY---IQLVEQL 468
Query: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
R ++LD D + ++++ + A++ + + + IA DW+ +
Sbjct: 469 RNTVALDADIAAQKLFWADLSQKAIFS---ASIDDKVGRHVKMIDNVYNPAAIAVDWVYK 525
Query: 2479 RIYYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
IY++D ++ I+ DG+ R + + + +P +I +DP G++YW+DW AKIE+A
Sbjct: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
Query: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AV 2593
+ G R P+V + + P+G+TLD + LYW+D+ L + L G DR +++ +
Sbjct: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
Query: 2594 HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNN 2653
H LT++ +YW D + +Y ANK+ GS ++A N L+ + I + + N
Sbjct: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGS-ELATLVNNLNDAQDIIVYHELVQPSGKN 704
Query: 2654 PCEQ--FNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
CE+ NGGC ++C P P + C CP + + N + C
Sbjct: 705 WCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP--SGYNVEENGRDC 749
Score = 152 bits (385), Expect = 6e-36
Identities = 100/373 (26%), Positives = 189/373 (50%), Gaps = 40/373 (10%)
Query: 2025 NMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS--FIVVSMLSAIRGFSLELSD 2082
N C QIC+ + GG + C C+ G++++ C ++ + IR LE +
Sbjct: 402 NPGICSQICINLKGG-YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 2083 HSETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-----SSVASDNAIRRIKPDGSSLMNI 2137
+ + + Q RN + +D D+++ ++W D S S+ D R +K + N+
Sbjct: 461 Y----IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK----MIDNV 512
Query: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197
IAVDWV +Y+T+A + I V ++ T R+ L + P I V
Sbjct: 513 YNPA-------AIAVDWVYKTIYWTDA--ASKTISVATLDGTKRKFLFNSDLREPASIAV 563
Query: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257
DP + +++W+D+G+ KIE++ ++ +R LV+ I P G+ +D +YW+D L +
Sbjct: 564 DPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
Query: 2258 IARIRINGENSEVIRYGSRY-PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVI 2316
++ + +NG++ ++ + P +T+FE+ + W+D + ++ A+K +E T++
Sbjct: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKF-TGSELATLV 682
Query: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLEN--NGGCSHLCFALPGL--HTPK--CDC 2370
+N+N +D+ ++ + VQP N C E+ NGGC +LC P + H+PK C C
Sbjct: 683 -NNLNDAQDIIVYHELVQPS-----GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
Query: 2371 AFG-TLQSDGKNC 2382
G ++ +G++C
Sbjct: 737 PSGYNVEENGRDC 749
Score = 136 bits (343), Expect = 4e-31
Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLR-DDQPFLITVRQHIIFGISLNPEVKS 1767
CS +C+ G Y C C G+ + C +P LI + I I L +
Sbjct: 406 CSQICINLKGG---YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL----ER 458
Query: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNL 1826
+ + + ++N + ++ D A Q ++W + + I D I V +
Sbjct: 459 KEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1827 ALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLY 1886
A+DW+ + +Y T+ +++I V TL G RK L +D + P I VDP G +Y
Sbjct: 519 AVDWVYKTIYWTDAASKTISVATLDGT--KRKFLFNSD-----LREPASIAVDPLSGFVY 571
Query: 1887 WSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERG 1946
WSD G PAKI A M+G + L T +++ +TLD+ + +LYW + ++
Sbjct: 572 WSDWGE----PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 1947 NVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPN 2003
+++G DR I++ L+HP + + + +Y+ D + E + +K TG+ L +N+ +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 2004 LRGLQVYHRRNAAESSNGCSNNM--NACQQICLPVP-----GGLFSCACATGFKLNPDNR 2056
+ + VYH N C +M C+ +CLP P ++C+C +G+ + + R
Sbjct: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
Query: 2057 SCSPYNSFIVVSMLS 2071
C N VS +S
Sbjct: 748 DCQRINVTTAVSEVS 762
Score = 135 bits (341), Expect = 7e-31
Identities = 74/237 (31%), Positives = 117/237 (49%), Gaps = 25/237 (10%)
Query: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQR-----FCRLGQFQCSDG 3563
P C + +F C+ + CIPI W CD DCSD SDE L C ++ C + QC G
Sbjct: 191 PTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG 249
Query: 3564 NCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNS 3623
C + C+ +C DGSDE + C + C ++++C + CI S QC+ DC D S
Sbjct: 250 ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
Query: 3624 DEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECM---------SS 3674
DE + ++ PG+F+C +G CI + C+ + DC D SDEP++EC
Sbjct: 308 DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
Query: 3675 AHLCDNFT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCK 3728
+H+C + E C + I + C +D+C++ C + + G ++C+
Sbjct: 368 SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGI---CSQICINLKGGYKCE 420
Score = 103 bits (258), Expect = 3e-21
Identities = 56/142 (39%), Positives = 74/142 (52%), Gaps = 12/142 (8%)
Query: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYS 3899
A C+ + F+C N CI WKCDGD+DC DGSDE+ C+ C + + F C+N +C+ S
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTC-AESDFVCNNGQCVPS 87
Query: 3900 HEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWS 3957
C+G DC DG+DE+ E C T C +E CG + CIP CD +DC
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
Query: 3958 DELGCN----KGKERTCAENIC 3975
DE C E TC+ C
Sbjct: 145 DEENCGNITCSPDEFTCSSGRC 166
Score = 36.6 bits (83), Expect = 0.60
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 17/89 (19%)
Query: 2644 VKNQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKH 2691
V NQ+Q C N C NGGCSHIC G EC C + L + +
Sbjct: 337 VCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDC--AAGFELIDRKTC 394
Query: 2692 CIVDNGERCGASSFTCSNGRCISEEWKCD 2720
+D + G S C N + +KC+
Sbjct: 395 GDIDECQNPGICSQICIN---LKGGYKCE 420
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 521 bits (1342), Expect = e-147
Identities = 286/733 (39%), Positives = 391/733 (53%), Gaps = 47/733 (6%)
Query: 2784 TEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCD 2843
++F C N RCI + C+G ++C D SDEKNC +TC C+N C+P + CD
Sbjct: 36 SQFQCTNGRCITLLWKCDGDEDCVDG--SDEKNCVKKTCAESDFVCNNGQ-CVPSRWKCD 92
Query: 2844 GDNDCGDNSDENPTYCTTHTCSSSEFQCA--SGRCIPQHWYCDQETDCFDASDEPASCGH 2901
GD DC D SDE+P C TC E C S +CIP W CD E DC D+ ++ +CG+
Sbjct: 93 GDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDEENCGN 151
Query: 2902 SERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPP 2961
TC DEF C GRCI ++C+G +DC D SDE C C EF C
Sbjct: 152 I--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE---LDCAPPTCGAHEFQCSTSS-- 204
Query: 2962 DRRCIPQSWVCDGDVDCTDGYDEN-QNCTRRT-----CSENEFTCGYGLCIPKIFRCDRH 3015
CIP SWVCD D DC+D DE+ + C R+ C +E CG G CI K +RCD
Sbjct: 205 ---CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGD 261
Query: 3016 NDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
DC D SDE C +TC+ +QF C++G CI + C+ DC DGSDE+ C
Sbjct: 262 PDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVN--CKNVNQCL 319
Query: 3076 PPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE--KGCGINECHDPSISGCDHNCTDTLTSF 3133
P +FKC +G CI++ K+CN DC D SDE K C INEC + GC H C D + +
Sbjct: 320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGY 378
Query: 3134 YCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQ 3193
C C G++L+ D++TC DIDEC + P +CSQ C N+ G Y C+C+ GY + C+
Sbjct: 379 ECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA 436
Query: 3194 NSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWID-TQRQVIE 3252
EP LIF+NR +R + ++ Y ++E L N VALD D ++L+W D +Q+ +
Sbjct: 437 VGK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFS 495
Query: 3253 RMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCV 3312
+K + + + ++AVDWV + +YW DA + V+ L+G R+ L +
Sbjct: 496 ASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDL 555
Query: 3313 DANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
P +A+ P G++YW+DWG A I + GM+G ++ +++ ++WPNGIT+
Sbjct: 556 R--------EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
Query: 3373 DYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTV 3430
D LYW D+ L + DL G R V L HP A+TIFED +YW D V
Sbjct: 608 DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
Query: 3431 EKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPC--GTNNGGCSHLCL----IKP 3484
NK+ GS TLVN + DI VYH QP N C NGGC +LCL I
Sbjct: 668 YGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIND 727
Query: 3485 GGKGFTCECPDDF 3497
+TC CP +
Sbjct: 728 HSPKYTCSCPSGY 740
Score = 504 bits (1298), Expect = e-142
Identities = 282/745 (37%), Positives = 395/745 (53%), Gaps = 34/745 (4%)
Query: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
E T +C F C NGRC+ + CDG +DC D SDE+ C + TC+ S F
Sbjct: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFV 78
Query: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH--QCISKNWVCDTD 1131
C +G+C+P+ W+CD DC DGSDE H +C + +C H QCI +W CD +
Sbjct: 79 CNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM-RTCRIHEISCGAHSTQCIPVSWRCDGE 137
Query: 1132 NDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL-NCTAS 1190
NDC G DE+NC + TC P +F C + RCI +FVC+G DC DGSDE+ C C A
Sbjct: 138 NDCDSGEDEENCGNI-TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH 196
Query: 1191 QFKCASGDKCIGVTNRCDGVFDCSDNSDEA--GCPTRPP--GMCHSDEFQCQEDGICIPN 1246
+F+C++ CI ++ CD DCSD SDE+ C +P C + E QC G CI
Sbjct: 197 EFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS-GECIHK 254
Query: 1247 FWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
W CDG PDC GSDE N C +TC F C++G+CIH + C+ DC D SDE +C
Sbjct: 255 KWRCDGDPDCKDGSDEVN-CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
Query: 1307 TQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--CNGNSCSDFNGGCTHEC 1364
+++C C+++S VC+ DC + +DE PL C+ N C NGGC+H C
Sbjct: 314 NVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDE-PLKECHINECLVNNGGCSHIC 371
Query: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424
G +C C GF L D KTC DIDEC G CSQ C N++G ++C C GY ++
Sbjct: 372 KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLA 430
Query: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
CK E L+ N+ + + LVE VA+D D + ++FW+D
Sbjct: 431 TGVCKAVGKEPSLIFT---NRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
Query: 1485 ATQGKTWSA-FQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
+Q +SA + R V ++ IA+DWV + +YWTD A +TI V+ +DG+ R
Sbjct: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Query: 1544 TVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGL 1603
L + +L P +A+DP ++WSDWG +IE+A M+G R +V I WP G+
Sbjct: 548 KFLFNSDLREPASIAVDPLSG--FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGI 605
Query: 1604 TIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATR 1663
T+D LY++DS L + D NG RR V+ S + HP ALT+FED VYW D
Sbjct: 606 TLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENE 665
Query: 1664 RVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCL----L 1715
V ANK+ G + ++ N+ I+ H QP+ N C C +LCL +
Sbjct: 666 AVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQI 725
Query: 1716 SSQGPHFYSCVCPSGWSLSPDLLNC 1740
+ P Y+C CPSG+++ + +C
Sbjct: 726 NDHSPK-YTCSCPSGYNVEENGRDC 749
Score = 483 bits (1242), Expect = e-135
Identities = 283/766 (36%), Positives = 400/766 (52%), Gaps = 78/766 (10%)
Query: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIP 3694
C P QF+C NGRCI WKCD D DC D SDE + C+ C ++F C N +C+P
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNCVKKT--CAE-SDFVCN-NGQCVP 86
Query: 3695 KWAVCNGVDDCRDNSDE--QGCEERTCHPVGDFRCKNH--HCIPLRWQCDGQNDCGDNSD 3750
C+G DC D SDE + C RTC + + C H CIP+ W+CDG+NDC D
Sbjct: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCR-IHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 3751 EENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHC 3810
EENC C+ EF C + +CI ++C+ +DC D SDE DC TC FQC++ C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSC 205
Query: 3811 VHSELKCDGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCG 3868
+ CD ADC D SDE+ C + C A+ +C + CI W+CDGD DC
Sbjct: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
Query: 3869 DGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETE----EHCRKPT 3924
DGSDE C C P++F C++ CI+ CNG+ DC DG+DE C P
Sbjct: 266 DGSDEVN--CPSRTCR-PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
Query: 3925 PKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQN---CTQ 3981
++KC +G CI VC+ DC DWSDE + C N C N C+
Sbjct: 323 -------KFKCRSGECIDISKVCNQEQDCRDWSDE------PLKECHINECLVNNGGCSH 369
Query: 3982 LNEG---GFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTS 4038
+ + G+ C C AGFE + DR +C DI+EC+ G C Q C N KG Y+C C+ G+
Sbjct: 370 ICKDLVIGYECDCAAGFE--LIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGY-- 425
Query: 4039 MSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGL 4098
D C A G P L+ + IRK L + + + ++ A+D DI
Sbjct: 426 QMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD-----ADIAA 480
Query: 4099 SVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYW 4158
+++ + + F A + + V+ +D V P IAVDWV + IYW
Sbjct: 481 QKLFWADLSQKAIFSA-------SIDDKVGRHVKMID----NVYNPAAIAVDWVYKTIYW 529
Query: 4159 SDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGE 4218
+D +K I VA LDG RK+L ++DL +PA+IAV+P G ++W+DWG+ KIE A MNG
Sbjct: 530 TDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGF 589
Query: 4219 DRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKE---AMNPY 4275
DR LV D+ WP G+++D + + R+YW D K ++ ++ +G DRR++ K +P
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKS-RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPL 648
Query: 4276 SLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQ-VRIFHQLRYNKSVPNLC 4334
+L IFED++YWI E V+ NKF G + TLV N Q + ++H+L S N C
Sbjct: 649 ALTIFEDRVYWIDGENEAVYGANKF-TGSELATLVNNLNDAQDIIVYHEL-VQPSGKNWC 706
Query: 4335 KQI-----CSHLCLLRP------GGYSCACPQGSSFIEGSTTECDA 4369
++ C +LCL P Y+C+CP G + +E + +C +
Sbjct: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYN-VEENGRDCQS 751
Score = 455 bits (1171), Expect = e-127
Identities = 265/770 (34%), Positives = 385/770 (50%), Gaps = 86/770 (11%)
Query: 12 LLLALVACLAP----ASGQ----ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63
L L L C AP A+G +C+ + F+C +G CI W+CDG +DC D +DE C
Sbjct: 9 LWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
Query: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER-QDCSQSTCSSHQITCS--NGQC 120
TC + F C + GQC+P+ W CD D DC+DGSDE + C TC H+I+C + QC
Sbjct: 69 KKTCAESDFVCNN-GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQC 127
Query: 121 IPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEIN 178
IP +RCD DC G DE +C TC ++ TC +G C + + C+ + DC D SDE++
Sbjct: 128 IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
Query: 179 CTE-ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACN-----YPTCGGYQFTCP 230
C C +EF C CIP ++VCD D DC D SDE C + C + C
Sbjct: 188 CAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 231 SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGIL 290
SG CI++ W CDG+ DCKD DE C S C P ++ C E G CI + C+GI
Sbjct: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPS-----RTCRPDQFEC-EDGSCIHGSRQCNGIR 301
Query: 291 DCPGREDENNTST-------GKY------------------------------CSMTLCS 313
DC DE N GK+ C + C
Sbjct: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
Query: 314 ALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLC 371
N C + C + G C C G+ + D +TC + D+CQ GIC Q C + G + C
Sbjct: 362 VNNGGCSHICKDLVIGYECDCAAGFELI--DRKTCGDIDECQNPGICSQICINLKGGYKC 419
Query: 372 HCEEGYILERGQ-YCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVA 430
C GY ++ CKA E S+IF+N RD+ + + + LVE VA+
Sbjct: 420 ECSRGYQMDLATGVCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDAD 477
Query: 431 FHYHLQRVFWTDTVQNKVFSVDIN---GLNIQEVLNVSVETPENLAVDWVNNKIYLVETK 487
Q++FW D Q +FS I+ G +++ + NV P +AVDWV IY +
Sbjct: 478 IA--AQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVY--NPAAIAVDWVYKTIYWTDAA 533
Query: 488 VNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEP-KLERAFMDGS 546
I + LDG+ R L +L P IAVDP G++++SDW GEP K+E+A M+G
Sbjct: 534 SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW----GEPAKIEKAGMNGF 589
Query: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
+R+ LV + WP G+TLD+I R+YW+DS+ + +V +G R+ V+ + HP
Sbjct: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
Query: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
+++FE +V++ D AV ANKFT + + VYH L QP N C+++
Sbjct: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
Query: 667 --NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFS 714
NGGCE +C+ + + ++ + C C G+ ++ + R C + + +S
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYS 759
Score = 243 bits (621), Expect = 2e-63
Identities = 145/416 (34%), Positives = 205/416 (49%), Gaps = 36/416 (8%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C +QF C N +CI + WKCDG +DC DGSDE C ++ C F C++G C +
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRWK 90
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA--NKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ +C DGSDE C C +E C + +CIP SW+CD NDC+ S ED +
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD--SGEDEEN 148
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTN 3689
C + TC P +F C++GRCI + + C+ +DC D SDE + A EF C T+
Sbjct: 149 CGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE-----LDCAPPTCGAHEFQCSTS 203
Query: 3690 YRCIPKWAVCNGVDDCRDNSDE--QGCEER----TCHPVGDFRCKNHHCIPLRWQCDGQN 3743
CIP VC+ DC D SDE + C + T P + +C + CI +W+CDG
Sbjct: 204 -SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDP 262
Query: 3744 DCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE-MRTC-HPE 3801
DC D SDE NC R C +F C + CI C+ DC D SDE +C+ + C P
Sbjct: 263 DCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
Query: 3802 YFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVC--IPPYW 3859
F+C SG C+ C+ DC D SDE P + C C +H+C + +
Sbjct: 323 KFKCRSGECIDISKVCNQEQDCRDWSDE---PLKECHINECLVNNGGC-SHICKDLVIGY 378
Query: 3860 KCD--------GDDDCGDGSD-EELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGV 3906
+CD CGD + + +C + N ++C+ +R Y ++ GV
Sbjct: 379 ECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG-YQMDLATGV 433
Score = 234 bits (596), Expect = 2e-60
Identities = 134/350 (38%), Positives = 181/350 (51%), Gaps = 31/350 (8%)
Query: 2676 QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESV 2735
+C + + ++ K+C+ + C S F C+NG+C+ WKCD D DC DGSDE
Sbjct: 51 KCDGDEDCVDGSDEKNCVK---KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQ 107
Query: 2736 CALHTCSPTAFTCA--NGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRC 2793
C + TC +C + +C+ S+RCD NDC G DE C C + EF C++ RC
Sbjct: 108 CHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITC-SPDEFTCSSGRC 166
Query: 2794 IPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSD 2853
I R F+CNG D+C D SDE +C TC + +C S+ CIP ++CD D DC D SD
Sbjct: 167 ISRNFVCNGQDDCSDG--SDELDCAPPTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSD 223
Query: 2854 ENPTYC----TTHT-CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLA 2908
E+ C HT C +SE QC SG CI + W CD + DC D SDE +C RTC
Sbjct: 224 ESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE-VNC--PSRTCRP 280
Query: 2909 DEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQN--CSDSEFLCVNDRPPDRRCI 2966
D+F+C+ G CI C+G DC D SDE C+N N +F C + CI
Sbjct: 281 DQFECEDGSCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSG-----ECI 332
Query: 2967 PQSWVCDGDVDCTDGYDEN-QNCTRRTCSENEFTCGYGLCIPKI--FRCD 3013
S VC+ + DC D DE + C C N C + +C + + CD
Sbjct: 333 DISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECD 381
Score = 218 bits (555), Expect = 1e-55
Identities = 124/342 (36%), Positives = 169/342 (49%), Gaps = 20/342 (5%)
Query: 3492 ECPDDFRTLQLSGSTYCMPM-CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCP 3549
+C D + S C+ C+ + F+C NN +C+P WKCDG DC DGSDE C
Sbjct: 51 KCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCH 109
Query: 3550 QRFCRLGQFQCS--DGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCI 3607
R CR+ + C C C+ +C G DE+ C N C +E+ C++ RCI
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEEN--CGNITCSPDEFTCSSGRCI 167
Query: 3608 PESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEP 3667
++ C+ +DC D SDE CA TC +F+C+ CIP +W CD D DC D SDE
Sbjct: 168 SRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDES 225
Query: 3668 IEEC--MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDF 3725
+E+C H +E C + CI K C+G DC+D SDE C RTC P F
Sbjct: 226 LEQCGRQPVIHTKCPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRP-DQF 283
Query: 3726 RCKNHHCIPLRWQCDGQNDCGDNSDEENCA-PRECT-ESEFRCVNQQCIPSRWICDHYND 3783
C++ CI QC+G DC D SDE NC +C +F+C + +CI +C+ D
Sbjct: 284 ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQD 343
Query: 3784 CGDNSDERDCEMRTCHPEYFQCTSGHCVH--SELKCDGSADC 3823
C D SDE ++ CH +G C H +L DC
Sbjct: 344 CRDWSDE---PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
Score = 189 bits (481), Expect = 4e-47
Identities = 118/308 (38%), Positives = 150/308 (48%), Gaps = 31/308 (10%)
Query: 3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKC 3817
+C S+F+C N +CI W CD DC D SDE++C +TC F C +G CV S KC
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
Query: 3818 DGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNH--VCIPPYWKCDGDDDCGDGSDE 3873
DG DC D SDE+ C R C+ C H CIP W+CDG++DC G DE
Sbjct: 92 DGDPDCEDGSDESPEQCHMR-----TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
Query: 3874 ELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEY 3933
E C ++ C SP+ F C + RCI + VCNG DDC DG+DE + C PT C +E+
Sbjct: 147 E--NCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPT---CGAHEF 198
Query: 3934 KCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFI----- 3988
+C CIP VCDD DC D SDE G++ C + Q G I
Sbjct: 199 QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ-PVIHTKCPASEIQCGSGECIHKKWR 257
Query: 3989 C----SCTAGF-ETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRP 4043
C C G E N RT D ECE G+C R G +CV DG ++ +
Sbjct: 258 CDGDPDCKDGSDEVNCPSRTCRPDQFECED-GSCIHGSRQCNGIRDCV--DGSDEVNCKN 314
Query: 4044 GKRCAAEG 4051
+C G
Sbjct: 315 VNQCLGPG 322
Score = 179 bits (455), Expect = 4e-44
Identities = 111/365 (30%), Positives = 179/365 (49%), Gaps = 24/365 (6%)
Query: 666 NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723
N G C Q+C+ N G++C+C+ G+Q+D C AV + LIF+++ IR I
Sbjct: 402 NPGICSQICI------NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
Query: 724 FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANR 782
++ + V +D D +F++D+S+ IF ID GR + +
Sbjct: 456 LERKEYIQLVEQLRNT----VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN 511
Query: 783 VENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYL 840
V N ++A DW+ K +YWTD+ K+ISV L D T+R + L P S+ V P +G++
Sbjct: 512 VYNPAAIAVDWVYKTIYWTDAASKTISVATL-DGTKRKFLFNSDLREPASIAVDPLSGFV 570
Query: 841 FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900
+++DW PAKI +A +G P++ + WPNG+ +D SRLYW+D+ + +
Sbjct: 571 YWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630
Query: 901 GLDRR-RLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILH 959
G DRR L +E + HP L IF + +++ D A+ K G E+ + + +
Sbjct: 631 GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD 690
Query: 960 LKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013
+ Y +Q +G N C + NG C + C P P + C CP G + N C
Sbjct: 691 IIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Query: 1014 EGDPT 1018
+ T
Sbjct: 750 QSTAT 754
Score = 165 bits (417), Expect = 1e-39
Identities = 111/421 (26%), Positives = 188/421 (44%), Gaps = 73/421 (17%)
Query: 2340 EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNC----------------- 2382
E + N CL NNGGCSH+C L + +CDCA G D K C
Sbjct: 354 ECHINECLVNNGGCSHICKDL--VIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICI 411
Query: 2383 ------------------------AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
A+ E LIF +R + L+ + + Q +
Sbjct: 412 NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY---IQLVEQL 468
Query: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
R ++LD D + ++++ + A++ + + + IA DW+ +
Sbjct: 469 RNTVALDADIAAQKLFWADLSQKAIFS---ASIDDKVGRHVKMIDNVYNPAAIAVDWVYK 525
Query: 2479 RIYYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
IY++D ++ I+ DG+ R + + + +P +I +DP G++YW+DW AKIE+A
Sbjct: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
Query: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AV 2593
+ G R P+V + + P+G+TLD + LYW+D+ L + L G DR +++ +
Sbjct: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
Query: 2594 HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNN 2653
H LT++ +YW D + +Y ANK+ GS ++A N L+ + I + + N
Sbjct: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGS-ELATLVNNLNDAQDIIVYHELVQPSGKN 704
Query: 2654 PCEQ--FNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHCIVDNGERCGASSF 2705
CE+ NGGC ++C P P + C CP N + +NG C +++
Sbjct: 705 WCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYN----------VEENGRDCQSTAT 754
Query: 2706 T 2706
T
Sbjct: 755 T 755
Score = 152 bits (385), Expect = 6e-36
Identities = 100/373 (26%), Positives = 189/373 (50%), Gaps = 40/373 (10%)
Query: 2025 NMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS--FIVVSMLSAIRGFSLELSD 2082
N C QIC+ + GG + C C+ G++++ C ++ + IR LE +
Sbjct: 402 NPGICSQICINLKGG-YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 2083 HSETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-----SSVASDNAIRRIKPDGSSLMNI 2137
+ + + Q RN + +D D+++ ++W D S S+ D R +K + N+
Sbjct: 461 Y----IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK----MIDNV 512
Query: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197
IAVDWV +Y+T+A + I V ++ T R+ L + P I V
Sbjct: 513 YNPA-------AIAVDWVYKTIYWTDA--ASKTISVATLDGTKRKFLFNSDLREPASIAV 563
Query: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257
DP + +++W+D+G+ KIE++ ++ +R LV+ I P G+ +D +YW+D L +
Sbjct: 564 DPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
Query: 2258 IARIRINGENSEVIRYGSRY-PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVI 2316
++ + +NG++ ++ + P +T+FE+ + W+D + ++ A+K +E T++
Sbjct: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKF-TGSELATLV 682
Query: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLEN--NGGCSHLCFALPGL--HTPK--CDC 2370
+N+N +D+ ++ + VQP N C E+ NGGC +LC P + H+PK C C
Sbjct: 683 -NNLNDAQDIIVYHELVQPS-----GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
Query: 2371 AFG-TLQSDGKNC 2382
G ++ +G++C
Sbjct: 737 PSGYNVEENGRDC 749
Score = 135 bits (341), Expect = 7e-31
Identities = 74/237 (31%), Positives = 117/237 (49%), Gaps = 25/237 (10%)
Query: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQR-----FCRLGQFQCSDG 3563
P C + +F C+ + CIPI W CD DCSD SDE L C ++ C + QC G
Sbjct: 191 PTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG 249
Query: 3564 NCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNS 3623
C + C+ +C DGSDE + C + C ++++C + CI S QC+ DC D S
Sbjct: 250 ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
Query: 3624 DEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECM---------SS 3674
DE + ++ PG+F+C +G CI + C+ + DC D SDEP++EC
Sbjct: 308 DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
Query: 3675 AHLCDNFT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCK 3728
+H+C + E C + I + C +D+C++ C + + G ++C+
Sbjct: 368 SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGI---CSQICINLKGGYKCE 420
Score = 133 bits (334), Expect = 5e-30
Identities = 95/362 (26%), Positives = 168/362 (46%), Gaps = 30/362 (8%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLR-DDQPFLITVRQHIIFGISLNPEVKS 1767
CS +C+ G Y C C G+ + C +P LI + I I L +
Sbjct: 406 CSQICINLKGG---YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL----ER 458
Query: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNL 1826
+ + + ++N + ++ D A Q ++W + + I D I V +
Sbjct: 459 KEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1827 ALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLY 1886
A+DW+ + +Y T+ +++I V TL G RK L +D + P I VDP G +Y
Sbjct: 519 AVDWVYKTIYWTDAASKTISVATLDGT--KRKFLFNSD-----LREPASIAVDPLSGFVY 571
Query: 1887 WSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERG 1946
WSD G PAKI A M+G + L T +++ +TLD+ + +LYW + ++
Sbjct: 572 WSDWGE----PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 1947 NVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPN 2003
+++G DR I++ L+HP + + + +Y+ D + E + +K TG+ L +N+ +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 2004 LRGLQVYHRRNAAESSNGCSNNM--NACQQICLPVP-----GGLFSCACATGFKLNPDNR 2056
+ + VYH N C +M C+ +CLP P ++C+C +G+ + + R
Sbjct: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
Query: 2057 SC 2058
C
Sbjct: 748 DC 749
Score = 103 bits (258), Expect = 3e-21
Identities = 56/142 (39%), Positives = 74/142 (52%), Gaps = 12/142 (8%)
Query: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYS 3899
A C+ + F+C N CI WKCDGD+DC DGSDE+ C+ C + + F C+N +C+ S
Sbjct: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTC-AESDFVCNNGQCVPS 87
Query: 3900 HEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWS 3957
C+G DC DG+DE+ E C T C +E CG + CIP CD +DC
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
Query: 3958 DELGCN----KGKERTCAENIC 3975
DE C E TC+ C
Sbjct: 145 DEENCGNITCSPDEFTCSSGRC 166
Score = 36.6 bits (83), Expect = 0.60
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 17/89 (19%)
Query: 2644 VKNQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKH 2691
V NQ+Q C N C NGGCSHIC G EC C + L + +
Sbjct: 337 VCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDC--AAGFELIDRKTC 394
Query: 2692 CIVDNGERCGASSFTCSNGRCISEEWKCD 2720
+D + G S C N + +KC+
Sbjct: 395 GDIDECQNPGICSQICIN---LKGGYKCE 420
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 506 bits (1302), Expect = e-142
Identities = 265/710 (37%), Positives = 382/710 (53%), Gaps = 48/710 (6%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
Query: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1184 VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG-- 1241
C +F+C + C+ CDG DC D SDE GC C EF+C DG
Sbjct: 164 ATLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPA---CGPREFRCGGDGGG 219
Query: 1242 ICIPNFWECDGHPDCLYGSDEHN----------ACVPKTCPS-SYFHCDNGNCIHRAWLC 1290
CIP W CD DC SDE P C + S F C +G C+H W C
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 1291 DRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG 1350
D D DC D SDE DCP C ++QC G CV C+ DCP+G+DE+ G
Sbjct: 280 DGDRDCKDKSDEADCPLGT--CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 1351 -NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
N C NGGC+H C G +C CP GF L D KTC DIDEC +CSQ C N +G
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKG 395
Query: 1410 SFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYI 1468
F+C C GY ++ + CK A +S L+ +++++ D V + +++N +
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---V 452
Query: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLY 1524
VA+D + + RI+W D + K +SA+ + ++ V+ D + E +A+DWV +++Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1525 WTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
WTD +TI V+ +DG R L S+NL+ PR +A+DP ++WSDWG +IE++ +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGL 570
Query: 1585 DGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRH 1644
+G R +V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+S + H
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
Query: 1645 PYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPC 1704
P+ + +FED V+WTD + AN+ +G S++ N+ P IV H KQP + + C
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
Query: 1705 AFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745
S C +LCL +SS P Y+C CP L PD+ C R Q
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 739
Score = 481 bits (1238), Expect = e-135
Identities = 260/736 (35%), Positives = 366/736 (49%), Gaps = 85/736 (11%)
Query: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW 2923
C +FQC + RCIP W CD++ DC D SDE C ++TC +F CD G CI W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DC--PKKTCADSDFTCDNGHCIHERW 103
Query: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
CDG+ +C D SDE + C Q C + C P +C+P SW CDG+ DC G D
Sbjct: 104 KCDGEEECPDGSDESEA-TCTKQVCPAEKLSC---GPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 2984 ENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQN-- 3041
E T C+ +EF CG C+ +F CD +DCGD SDERGC C +F C
Sbjct: 160 EAGCAT--LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
Query: 3042 -GRCISKTFVCDEDNDCGDGSDELMHLCHTPEP--------------------------- 3073
G CI + +VCD DC D SDE LC P P
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 3074 --------------------TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GI 3111
TC EF+C +G C+ +K CN DC D SDE GC G+
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
Query: 3112 NECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVI 3171
NEC + GC H CTD F C+C G++L+ D++TC DIDEC + P CSQ C N
Sbjct: 338 NECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYK 394
Query: 3172 GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVA 3231
G + C+C PGY + K C+ + P LIF+NR+ +R + + YS ++ L NVVA
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVA 454
Query: 3232 LDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAESLAVDWVSRKLYWL 3287
LD + R+YW D + I +++K + +E +I+ +L + E LAVDWV + +YW
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347
D+ + V+ ++GG RR L + PR +A+ P G++YW+DWG +A I
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLS--------EPRAIAVDPLRGFMYWSDWGDQAKIE 566
Query: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA- 3406
+ G++G ++ ++S +EWPNGIT+D + LYW D+ L + D G +R T+
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 3407 -LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIV 3465
L HPF I +FED ++WTD + N+ +G L + P DI ++H +QP
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
Query: 3466 SNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFL 3518
+ C + NGGC +LCL I +TC CPD Y P +ST L
Sbjct: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTL 746
Query: 3519 CANNEKCIPIWWKCDG 3534
+ + +P + G
Sbjct: 747 ASTMTRTVPATTRAPG 762
Score = 431 bits (1108), Expect = e-120
Identities = 239/708 (33%), Positives = 367/708 (51%), Gaps = 47/708 (6%)
Query: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
++C+ F+C + CIP+ WRCD DC D +DE C TC F C + G CI W
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
Query: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142
CD +++C DGSDE + C++ C + +++C ++ +C+P+ +RCD +DC GADE C
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 143 QYPTC-EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE-ICLHNEFSCGN---GECIP 197
+ C N +C CD DC D SDE C + C EF CG G CIP
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIP 223
Query: 198 RAYVCDHDNDCQDGSDEHA--CNYPTCGGY----------QFTCPSGRCIYQNWVCDGED 245
+VCD DC+D SDE A C P G QF C SG C++ W CDG+
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 246 DCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK 305
DCKD DE C G C E+ C + G C+ K C+ DCP DE G
Sbjct: 284 DCKDKSDEADCPLGT-----CRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG- 336
Query: 306 YCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESR 365
+ L + C + C + G C CP G+ + D +TC + D+C+ C Q C +
Sbjct: 337 -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQICVNY 393
Query: 366 PGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNR 423
G C C GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+
Sbjct: 394 KGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 424 GVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVDWVNN 479
VA+ V R++W D K++S ++ + QEVL + + +PE LAVDWV+
Sbjct: 452 VVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 480 KIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLE 539
IY ++ I + +DG R TL + NL PR IAVDP G++++SDW + K+E
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQAKIE 566
Query: 540 RAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGS 599
++ ++G +R+ LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 600 LIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYA 659
+ HPFG+++FE +VF+TD A+ AN+ + + P+ + ++H L+QP A
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
Query: 660 TNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
+ C+ NGGCE +C+ + + + + C C L D + C
Sbjct: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 395 bits (1014), Expect = e-109
Identities = 249/761 (32%), Positives = 374/761 (49%), Gaps = 120/761 (15%)
Query: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE---PIEECMSSAHLCDNFTEFSCKT 3688
++ C QF+C N RCIP W+CD D+DC DHSDE P + C S CD
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--------- 94
Query: 3689 NYRCIPKWAVCNGVDDCRDNSDEQ--GCEERTCHPVGDFRC--KNHHCIPLRWQCDGQND 3744
N CI + C+G ++C D SDE C ++ C P C +H C+P W+CDG+ D
Sbjct: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKD 153
Query: 3745 CGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQ 3804
C +DE CA C EF+C N+ C+ + ++CD +DCGD SDER C C P F+
Sbjct: 154 CEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFR 212
Query: 3805 C---TSGHCVHSELKCDGSADCLDASDEAD--CPTRFP-----DGAYCQATMFECKNHVC 3854
C G C+ CD DC D SDEA C P A A+ F C++ C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 3855 IPPYWKCDGDDDCGDGSDEELHLCLDVPCNS--PNRFRCDNNRCIYSHEVCNGVDDCGDG 3912
+ W+CDGD DC D SDE D P + + F+C + C+ + + CN DC DG
Sbjct: 273 VHLGWRCDGDRDCKDKSDE-----ADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDG 327
Query: 3913 TDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAE 3972
+DE C + G C+ ++ C
Sbjct: 328 SDEA----------GCLQ-----GLNECLHNNGGC------------------------S 348
Query: 3973 NICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVC 4032
+IC T L G F C+C AGF+ + D+ +C DI+EC+ C Q C N KG ++C C
Sbjct: 349 HIC----TDLKIG-FECTCPAGFQ--LLDQKTCGDIDECKDPDACSQICVNYKGYFKCEC 401
Query: 4033 ADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDW 4091
G+ D K C AA G SP L+ + +R+ +L +S + + + A+D
Sbjct: 402 YPGYE--MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV-- 457
Query: 4092 DPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDW 4151
++ + +Y+ + ++ Y + + QEV L + + P+G+AVDW
Sbjct: 458 ---EVATNRIYWCDL-------SYRKIYSAYMDKASDPKEQEV-LIDEQLHSPEGLAVDW 506
Query: 4152 VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIE 4211
V +HIYW+D NK I VA +DG R+ L S +L +P AIAV+P G M+W+DWG + KIE
Sbjct: 507 VHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIE 566
Query: 4212 SAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEA 4271
+ +NG DR LV +++ WP G+++D L + R+YW D K + +I + G +R+ +
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWVDSKLHQLSSIDFSGGNRKTLISST 625
Query: 4272 ---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTL---VVNPWLTQVRIFHQLR 4325
+P+ + +FED+++W E ++ N+ G + L + NP + IFH+L+
Sbjct: 626 DFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGLEISILAENLNNP--HDIVIFHELK 682
Query: 4326 YNKSVPNLCKQI------CSHLCLLRP------GGYSCACP 4354
++ P+ C+ C +LCL P Y+CACP
Sbjct: 683 QPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Score = 237 bits (604), Expect = 2e-61
Identities = 198/706 (28%), Positives = 293/706 (41%), Gaps = 108/706 (15%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 2760 CDYYNDCGDGSD--EAGCLFRDCNATTEFMC--NNRRCIPREFICNGVDNCHDNNTSDEK 2815
CD +C DGSD EA C + C A + C + +C+P + C+G +C +DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPA-EKLSCGPTSHKCVPASWRCDGEKDCEGG--ADEA 161
Query: 2816 NCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQC---A 2872
C C +C N + C+ V++CDGD+DCGD SDE C C EF+C
Sbjct: 162 GCA-TLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDG 217
Query: 2873 SGRCIPQHWYCDQETDCFDASDEPAS-CGH-------SERTC-LADEFKCDGGRCIPSEW 2923
G CIP+ W CD++ DC D SDE A CG + C A +F C G C+ W
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
CDGD DC D SDE C C EF C D C+ C+ + DC DG D
Sbjct: 278 RCDGDRDCKDKSDE---ADCPLGTCRGDEFQC-----GDGTCVLAIKHCNQEQDCPDGSD 329
Query: 2984 ENQNCTR--RTCSENEFTCGYGLCIPKI-FRCDRHNDCGDYSDERGCLYQTCQQNQFTCQ 3040
E C + C N C + KI F C TC
Sbjct: 330 E-AGCLQGLNECLHNNGGCSHICTDLKIGFEC-------------------------TCP 363
Query: 3041 NGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDC 3100
G + C + ++C D D +C + FKC+ EM L
Sbjct: 364 AGFQLLDQKTCGDIDECKD-PDACSQICVNYK-----GYFKCECYPGYEMDLL------- 410
Query: 3101 LDNSDEKGCGINECHDPSISGCDHN---CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECT 3157
K C PS+ + + D + Y P M +D++ T
Sbjct: 411 -----TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNVVALDVEVAT 461
Query: 3158 EMPFVCSQKCENVIGSYICKCA---------PGYLREPDGKTCRQNSNIEPYLIFSNRYY 3208
+ C + +Y+ K + L P+G + Y S
Sbjct: 462 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAV-DWVHKHIYWTDSGNKT 520
Query: 3209 LRNLTID-GYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQV-IERMFLNKTNKETIIN 3266
+ T+D G +L L A+ D + +YW D Q IE+ LN +++T+++
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 3267 HRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGL 3326
+ + +D +S++LYW+D++L L D +GG+R+ L ++T +P G+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL------ISSTDFLSHPFGI 634
Query: 3327 ALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
A+ ++W D + A ++G S I++ L P+ I I
Sbjct: 635 AVFED--KVFWTDLENEAIFSANRLNGLEIS-ILAENLNNPHDIVI 677
Score = 217 bits (553), Expect = 2e-55
Identities = 128/384 (33%), Positives = 172/384 (44%), Gaps = 65/384 (16%)
Query: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
P + C QFQC + C C+ +C D SDED C C +++ C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIH 100
Query: 3609 ESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC--ANGRCIPQAWKCDVDNDCGDHSDE 3666
E W+CD +C D SDE + C + C + C + +C+P +W+CD + DC +DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFR 3726
+ + H EF C N C+ VC+G DDC D SDE+GC + C P +FR
Sbjct: 161 AGCATLCAPH------EFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP-REFR 212
Query: 3727 CKNH---HCIPLRWQCDGQNDCGDNSDE--ENC---------APREC-TESEFRCVNQQC 3771
C CIP RW CD Q DC D SDE E C AP C T S+F C + +C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEAD 3831
+ W CD DC D SDE DC + TC + FQC G CV + C+ DC D SDEA
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
Query: 3832 CPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPN 3887
C G ++C + H+C D+ C P
Sbjct: 333 C----------------------------LQGLNECLHNNGGCSHICTDLKIGFECTCPA 364
Query: 3888 RFRCDNNRCIYSHEVCNGVDDCGD 3911
F+ + + C +D+C D
Sbjct: 365 GFQ------LLDQKTCGDIDECKD 382
Score = 217 bits (552), Expect = 2e-55
Identities = 128/375 (34%), Positives = 171/375 (45%), Gaps = 45/375 (12%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE +
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC--K 3687
CA+ C P +F+C N C+ + CD D+DCGD SDE C A C EF C
Sbjct: 163 CAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE--RGCADPA--CGP-REFRCGGD 216
Query: 3688 TNYRCIPKWAVCNGVDDCRDNSDEQG-----------CEERTCHPVGDFRCKNHHCIPLR 3736
CIP+ VC+ DC D SDE C F C++ C+ L
Sbjct: 217 GGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG 276
Query: 3737 WQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMR 3796
W+CDG DC D SDE +C C EF+C + C+ + C+ DC D SDE C
Sbjct: 277 WRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3797 TCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP--DGAYCQATMFECK---- 3850
C+H+ C L E CP F D C + ECK
Sbjct: 337 L----------NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC-GDIDECKDPDA 385
Query: 3851 -NHVCI--PPYWKCD 3862
+ +C+ Y+KC+
Sbjct: 386 CSQICVNYKGYFKCE 400
Score = 175 bits (443), Expect = 1e-42
Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 380 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 432
Query: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 433 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 488
Query: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 489 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 548
Query: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 549 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 608
Query: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 609 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 668
Query: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 669 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
Query: 1004 MRLASNHLTCEGDPTNEPPT 1023
M L + C P + T
Sbjct: 725 MWLGPDMKRCYRAPQSTSTT 744
Score = 168 bits (425), Expect = 1e-40
Identities = 109/344 (31%), Positives = 156/344 (45%), Gaps = 41/344 (11%)
Query: 3493 CPDDFRTLQLSGSTYC-MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCPQ 3550
C +D L S C C+ + F C N CI WKCDG+++C DGSDE A C +
Sbjct: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH-CIHERWKCDGEEECPDGSDESEATCTK 124
Query: 3551 RFCRLGQFQC--SDGNCTSPQTLCNAHQNCPDGSDED--RLLCENHHCDSNEWQCANKRC 3606
+ C + C + C C+ ++C G+DE LC H E+QC N+ C
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPH-----EFQCGNRSC 179
Query: 3607 IPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC---ANGRCIPQAWKCDVDNDCGDH 3663
+ + CD +DC D SDE CA C P +FRC G CIP+ W CD DC D
Sbjct: 180 LAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
Query: 3664 SDEPIEEC-------MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEE 3716
SDE E C S+ C ++F+C++ C+ C+G DC+D SDE C
Sbjct: 238 SDEAAELCGRPGPGATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPL 296
Query: 3717 RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAP--RECTESEFRC-------- 3766
TC +F+C + C+ C+ + DC D SDE C EC + C
Sbjct: 297 GTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK 355
Query: 3767 VNQQC-IPSRWICDHYNDCGDNSDERD----CEMRTCHPEYFQC 3805
+ +C P+ + CGD + +D ++ + YF+C
Sbjct: 356 IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC 399
Score = 168 bits (425), Expect = 1e-40
Identities = 114/406 (28%), Positives = 193/406 (47%), Gaps = 66/406 (16%)
Query: 2344 NPCLENNGGCSHLCFALP-GLHTPKCDCAFGTLQSDGKNCA------------------- 2383
N CL NNGGCSH+C L G +C C G D K C
Sbjct: 338 NECLHNNGGCSHICTDLKIGF---ECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
Query: 2384 --------------ISTENF---------LIFALSNSLRSLHLDPENHSPPFQTINVERT 2420
+ T+N LIF + +R + L N+S + I + +
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKN 451
Query: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
V++LD + ++RIY+ + S +I + + +G+A DW+ + I
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 2481 YYSDYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLG 2538
Y++D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHA 2595
G R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
FG+ ++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + C
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDAC 690
Query: 2656 E---QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
E Q NGGC ++C P P + C CP +L + K C
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 734
Score = 162 bits (411), Expect = 6e-39
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 384 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
Query: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 443 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 492
Query: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 493 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
Query: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 611 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 668
Query: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 669 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 720
Score = 136 bits (343), Expect = 4e-31
Identities = 89/259 (34%), Positives = 118/259 (45%), Gaps = 31/259 (11%)
Query: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
CEG C F C N C+ ++CDG DDC D SDE+ C + C F
Sbjct: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREF 211
Query: 1073 TC---GHGECIPAHWRCDKRNDCVDGSDE--HNC------PTHAPASCLD-TQYTCDNHQ 1120
C G G CIP W CD++ DC D SDE C T APA+C +Q+ C + +
Sbjct: 212 RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE 271
Query: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
C+ W CD D DC D SDE +C TC+ +F C + C+ C+ ++DC DGSDE
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 1181 VGCV--LN-CTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC 1230
GC+ LN C + C+ D IG C F D DE P +C
Sbjct: 331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
Query: 1231 --HSDEFQCQEDGICIPNF 1247
+ F+C+ C P +
Sbjct: 391 VNYKGYFKCE----CYPGY 405
Score = 135 bits (339), Expect = 1e-30
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 386 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 439
Query: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 440 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 498 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 549
Query: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 550 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 605
Query: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 606 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 665
Query: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 666 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Query: 2050 KLNPDNRSC 2058
L PD + C
Sbjct: 726 WLGPDMKRC 734
Score = 110 bits (275), Expect = 3e-23
Identities = 55/162 (33%), Positives = 75/162 (46%), Gaps = 38/162 (23%)
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
+ C +++F C CIP ++RCD +DC D+SDE C +TC + FTC NG CI + +
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3051 CDEDNDCGDGSDELMHLC----------------HTPEPT-------------------- 3074
CD + +C DGSDE C H P
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3075 --CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINEC 3114
C PHEF+C N C+ + +C+ DDC D SDE+GC C
Sbjct: 165 TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC 206
Score = 86.7 bits (213), Expect = 5e-16
Identities = 56/162 (34%), Positives = 77/162 (47%), Gaps = 25/162 (15%)
Query: 3504 GSTYCMPMCSS-TQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD 3562
G+T C++ +QF C + E C+ + W+CDG +DC D SDE A CP CR +FQC D
Sbjct: 251 GATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQCGD 308
Query: 3563 GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCAN---------KRCIPESWQ- 3612
G C CN Q+CPDGSDE L + C N C++ + P +Q
Sbjct: 309 GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL 368
Query: 3613 -----CDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIP 3649
C ++C+D D S C + G F+C C P
Sbjct: 369 LDQKTCGDIDECKD-PDACSQICVN---YKGYFKC---ECYP 403
Score = 75.5 bits (184), Expect = 1e-12
Identities = 58/172 (33%), Positives = 72/172 (41%), Gaps = 27/172 (15%)
Query: 1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC-LGHNICVN 1327
K C F C N CI W CD D+DC D SDE DCP + C + C GH C++
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGH--CIH 100
Query: 1328 LSVVCDGIFDCPNGTDES-PLCNGNSCSDFNGGC---THECVQEPFGAKCLCPLGFLLAN 1383
CDG +CP+G+DES C C C +H+CV P +C +
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV--PASWRC---------D 149
Query: 1384 DSKTCE-DIDECDILGSCSQH---CYN---MRGSFRCSCDTGYMLESDGRTC 1428
K CE DE C+ H C N + F C D SD R C
Sbjct: 150 GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 37.4 bits (85), Expect = 0.35
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)
Query: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678
NQ+Q C N C NGGCSHIC G EC CP
Sbjct: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Score = 33.1 bits (74), Expect = 6.6
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 347 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 402
Query: 4391 FD-ETDL--PKCKCPSG 4404
E DL CK +G
Sbjct: 403 PGYEMDLLTKNCKAAAG 419
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 506 bits (1302), Expect = e-142
Identities = 265/710 (37%), Positives = 382/710 (53%), Gaps = 48/710 (6%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
Query: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1184 VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG-- 1241
C +F+C + C+ CDG DC D SDE GC C EF+C DG
Sbjct: 164 ATLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPA---CGPREFRCGGDGGG 219
Query: 1242 ICIPNFWECDGHPDCLYGSDEHN----------ACVPKTCPS-SYFHCDNGNCIHRAWLC 1290
CIP W CD DC SDE P C + S F C +G C+H W C
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 1291 DRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG 1350
D D DC D SDE DCP C ++QC G CV C+ DCP+G+DE+ G
Sbjct: 280 DGDRDCKDKSDEADCPLGT--CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 1351 -NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
N C NGGC+H C G +C CP GF L D KTC DIDEC +CSQ C N +G
Sbjct: 337 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKG 395
Query: 1410 SFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYI 1468
F+C C GY ++ + CK A +S L+ +++++ D V + +++N +
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---V 452
Query: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLY 1524
VA+D + + RI+W D + K +SA+ + ++ V+ D + E +A+DWV +++Y
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 1525 WTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
WTD +TI V+ +DG R L S+NL+ PR +A+DP ++WSDWG +IE++ +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGL 570
Query: 1585 DGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRH 1644
+G R +V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+S + H
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
Query: 1645 PYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPC 1704
P+ + +FED V+WTD + AN+ +G S++ N+ P IV H KQP + + C
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
Query: 1705 AFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745
S C +LCL +SS P Y+C CP L PD+ C R Q
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 739
Score = 481 bits (1238), Expect = e-135
Identities = 260/736 (35%), Positives = 366/736 (49%), Gaps = 85/736 (11%)
Query: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW 2923
C +FQC + RCIP W CD++ DC D SDE C ++TC +F CD G CI W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DC--PKKTCADSDFTCDNGHCIHERW 103
Query: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
CDG+ +C D SDE + C Q C + C P +C+P SW CDG+ DC G D
Sbjct: 104 KCDGEEECPDGSDESEA-TCTKQVCPAEKLSC---GPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 2984 ENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQN-- 3041
E T C+ +EF CG C+ +F CD +DCGD SDERGC C +F C
Sbjct: 160 EAGCAT--LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
Query: 3042 -GRCISKTFVCDEDNDCGDGSDELMHLCHTPEP--------------------------- 3073
G CI + +VCD DC D SDE LC P P
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 3074 --------------------TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GI 3111
TC EF+C +G C+ +K CN DC D SDE GC G+
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
Query: 3112 NECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVI 3171
NEC + GC H CTD F C+C G++L+ D++TC DIDEC + P CSQ C N
Sbjct: 338 NECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYK 394
Query: 3172 GSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVA 3231
G + C+C PGY + K C+ + P LIF+NR+ +R + + YS ++ L NVVA
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVA 454
Query: 3232 LDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAESLAVDWVSRKLYWL 3287
LD + R+YW D + I +++K + +E +I+ +L + E LAVDWV + +YW
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347
D+ + V+ ++GG RR L + PR +A+ P G++YW+DWG +A I
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLS--------EPRAIAVDPLRGFMYWSDWGDQAKIE 566
Query: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA- 3406
+ G++G ++ ++S +EWPNGIT+D + LYW D+ L + D G +R T+
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 3407 -LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIV 3465
L HPF I +FED ++WTD + N+ +G L + P DI ++H +QP
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
Query: 3466 SNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFL 3518
+ C + NGGC +LCL I +TC CPD Y P +ST L
Sbjct: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTL 746
Query: 3519 CANNEKCIPIWWKCDG 3534
+ + +P + G
Sbjct: 747 ASTMTRTVPATTRAPG 762
Score = 431 bits (1108), Expect = e-120
Identities = 239/708 (33%), Positives = 367/708 (51%), Gaps = 47/708 (6%)
Query: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
++C+ F+C + CIP+ WRCD DC D +DE C TC F C + G CI W
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
Query: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142
CD +++C DGSDE + C++ C + +++C ++ +C+P+ +RCD +DC GADE C
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 143 QYPTC-EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE-ICLHNEFSCGN---GECIP 197
+ C N +C CD DC D SDE C + C EF CG G CIP
Sbjct: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIP 223
Query: 198 RAYVCDHDNDCQDGSDEHA--CNYPTCGGY----------QFTCPSGRCIYQNWVCDGED 245
+VCD DC+D SDE A C P G QF C SG C++ W CDG+
Sbjct: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
Query: 246 DCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK 305
DCKD DE C G C E+ C + G C+ K C+ DCP DE G
Sbjct: 284 DCKDKSDEADCPLGT-----CRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG- 336
Query: 306 YCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESR 365
+ L + C + C + G C CP G+ + D +TC + D+C+ C Q C +
Sbjct: 337 -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQICVNY 393
Query: 366 PGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNR 423
G C C GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+
Sbjct: 394 KGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
Query: 424 GVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVDWVNN 479
VA+ V R++W D K++S ++ + QEVL + + +PE LAVDWV+
Sbjct: 452 VVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 480 KIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLE 539
IY ++ I + +DG R TL + NL PR IAVDP G++++SDW + K+E
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQAKIE 566
Query: 540 RAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGS 599
++ ++G +R+ LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
Query: 600 LIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYA 659
+ HPFG+++FE +VF+TD A+ AN+ + + P+ + ++H L+QP A
Sbjct: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
Query: 660 TNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
+ C+ NGGCE +C+ + + + + C C L D + C
Sbjct: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 395 bits (1014), Expect = e-109
Identities = 249/761 (32%), Positives = 374/761 (49%), Gaps = 120/761 (15%)
Query: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE---PIEECMSSAHLCDNFTEFSCKT 3688
++ C QF+C N RCIP W+CD D+DC DHSDE P + C S CD
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--------- 94
Query: 3689 NYRCIPKWAVCNGVDDCRDNSDEQ--GCEERTCHPVGDFRC--KNHHCIPLRWQCDGQND 3744
N CI + C+G ++C D SDE C ++ C P C +H C+P W+CDG+ D
Sbjct: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKD 153
Query: 3745 CGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQ 3804
C +DE CA C EF+C N+ C+ + ++CD +DCGD SDER C C P F+
Sbjct: 154 CEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFR 212
Query: 3805 C---TSGHCVHSELKCDGSADCLDASDEAD--CPTRFP-----DGAYCQATMFECKNHVC 3854
C G C+ CD DC D SDEA C P A A+ F C++ C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 3855 IPPYWKCDGDDDCGDGSDEELHLCLDVPCNS--PNRFRCDNNRCIYSHEVCNGVDDCGDG 3912
+ W+CDGD DC D SDE D P + + F+C + C+ + + CN DC DG
Sbjct: 273 VHLGWRCDGDRDCKDKSDE-----ADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDG 327
Query: 3913 TDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAE 3972
+DE C + G C+ ++ C
Sbjct: 328 SDEA----------GCLQ-----GLNECLHNNGGC------------------------S 348
Query: 3973 NICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVC 4032
+IC T L G F C+C AGF+ + D+ +C DI+EC+ C Q C N KG ++C C
Sbjct: 349 HIC----TDLKIG-FECTCPAGFQ--LLDQKTCGDIDECKDPDACSQICVNYKGYFKCEC 401
Query: 4033 ADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDW 4091
G+ D K C AA G SP L+ + +R+ +L +S + + + A+D
Sbjct: 402 YPGYE--MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV-- 457
Query: 4092 DPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDW 4151
++ + +Y+ + ++ Y + + QEV L + + P+G+AVDW
Sbjct: 458 ---EVATNRIYWCDL-------SYRKIYSAYMDKASDPKEQEV-LIDEQLHSPEGLAVDW 506
Query: 4152 VGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIE 4211
V +HIYW+D NK I VA +DG R+ L S +L +P AIAV+P G M+W+DWG + KIE
Sbjct: 507 VHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIE 566
Query: 4212 SAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEA 4271
+ +NG DR LV +++ WP G+++D L + R+YW D K + +I + G +R+ +
Sbjct: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWVDSKLHQLSSIDFSGGNRKTLISST 625
Query: 4272 ---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTL---VVNPWLTQVRIFHQLR 4325
+P+ + +FED+++W E ++ N+ G + L + NP + IFH+L+
Sbjct: 626 DFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGLEISILAENLNNP--HDIVIFHELK 682
Query: 4326 YNKSVPNLCKQI------CSHLCLLRP------GGYSCACP 4354
++ P+ C+ C +LCL P Y+CACP
Sbjct: 683 QPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
Score = 237 bits (604), Expect = 2e-61
Identities = 198/706 (28%), Positives = 293/706 (41%), Gaps = 108/706 (15%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 2760 CDYYNDCGDGSD--EAGCLFRDCNATTEFMC--NNRRCIPREFICNGVDNCHDNNTSDEK 2815
CD +C DGSD EA C + C A + C + +C+P + C+G +C +DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPA-EKLSCGPTSHKCVPASWRCDGEKDCEGG--ADEA 161
Query: 2816 NCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQC---A 2872
C C +C N + C+ V++CDGD+DCGD SDE C C EF+C
Sbjct: 162 GCA-TLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDG 217
Query: 2873 SGRCIPQHWYCDQETDCFDASDEPAS-CGH-------SERTC-LADEFKCDGGRCIPSEW 2923
G CIP+ W CD++ DC D SDE A CG + C A +F C G C+ W
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
CDGD DC D SDE C C EF C D C+ C+ + DC DG D
Sbjct: 278 RCDGDRDCKDKSDE---ADCPLGTCRGDEFQC-----GDGTCVLAIKHCNQEQDCPDGSD 329
Query: 2984 ENQNCTR--RTCSENEFTCGYGLCIPKI-FRCDRHNDCGDYSDERGCLYQTCQQNQFTCQ 3040
E C + C N C + KI F C TC
Sbjct: 330 E-AGCLQGLNECLHNNGGCSHICTDLKIGFEC-------------------------TCP 363
Query: 3041 NGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDC 3100
G + C + ++C D D +C + FKC+ EM L
Sbjct: 364 AGFQLLDQKTCGDIDECKD-PDACSQICVNYK-----GYFKCECYPGYEMDLL------- 410
Query: 3101 LDNSDEKGCGINECHDPSISGCDHN---CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECT 3157
K C PS+ + + D + Y P M +D++ T
Sbjct: 411 -----TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNVVALDVEVAT 461
Query: 3158 EMPFVCSQKCENVIGSYICKCA---------PGYLREPDGKTCRQNSNIEPYLIFSNRYY 3208
+ C + +Y+ K + L P+G + Y S
Sbjct: 462 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAV-DWVHKHIYWTDSGNKT 520
Query: 3209 LRNLTID-GYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQV-IERMFLNKTNKETIIN 3266
+ T+D G +L L A+ D + +YW D Q IE+ LN +++T+++
Sbjct: 521 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVS 580
Query: 3267 HRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGL 3326
+ + +D +S++LYW+D++L L D +GG+R+ L ++T +P G+
Sbjct: 581 DNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL------ISSTDFLSHPFGI 634
Query: 3327 ALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
A+ ++W D + A ++G S I++ L P+ I I
Sbjct: 635 AVFED--KVFWTDLENEAIFSANRLNGLEIS-ILAENLNNPHDIVI 677
Score = 217 bits (553), Expect = 2e-55
Identities = 128/384 (33%), Positives = 172/384 (44%), Gaps = 65/384 (16%)
Query: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
P + C QFQC + C C+ +C D SDED C C +++ C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIH 100
Query: 3609 ESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC--ANGRCIPQAWKCDVDNDCGDHSDE 3666
E W+CD +C D SDE + C + C + C + +C+P +W+CD + DC +DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFR 3726
+ + H EF C N C+ VC+G DDC D SDE+GC + C P +FR
Sbjct: 161 AGCATLCAPH------EFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP-REFR 212
Query: 3727 CKNH---HCIPLRWQCDGQNDCGDNSDE--ENC---------APREC-TESEFRCVNQQC 3771
C CIP RW CD Q DC D SDE E C AP C T S+F C + +C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEAD 3831
+ W CD DC D SDE DC + TC + FQC G CV + C+ DC D SDEA
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
Query: 3832 CPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPN 3887
C G ++C + H+C D+ C P
Sbjct: 333 C----------------------------LQGLNECLHNNGGCSHICTDLKIGFECTCPA 364
Query: 3888 RFRCDNNRCIYSHEVCNGVDDCGD 3911
F+ + + C +D+C D
Sbjct: 365 GFQ------LLDQKTCGDIDECKD 382
Score = 217 bits (552), Expect = 2e-55
Identities = 128/375 (34%), Positives = 171/375 (45%), Gaps = 45/375 (12%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE +
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC--K 3687
CA+ C P +F+C N C+ + CD D+DCGD SDE C A C EF C
Sbjct: 163 CAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE--RGCADPA--CGP-REFRCGGD 216
Query: 3688 TNYRCIPKWAVCNGVDDCRDNSDEQG-----------CEERTCHPVGDFRCKNHHCIPLR 3736
CIP+ VC+ DC D SDE C F C++ C+ L
Sbjct: 217 GGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG 276
Query: 3737 WQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMR 3796
W+CDG DC D SDE +C C EF+C + C+ + C+ DC D SDE C
Sbjct: 277 WRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
Query: 3797 TCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP--DGAYCQATMFECK---- 3850
C+H+ C L E CP F D C + ECK
Sbjct: 337 L----------NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC-GDIDECKDPDA 385
Query: 3851 -NHVCI--PPYWKCD 3862
+ +C+ Y+KC+
Sbjct: 386 CSQICVNYKGYFKCE 400
Score = 175 bits (443), Expect = 1e-42
Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 380 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 432
Query: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 433 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 488
Query: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 489 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 548
Query: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 549 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 608
Query: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 609 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 668
Query: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 669 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
Query: 1004 MRLASNHLTCEGDPTNEPPT 1023
M L + C P + T
Sbjct: 725 MWLGPDMKRCYRAPQSTSTT 744
Score = 168 bits (425), Expect = 1e-40
Identities = 109/344 (31%), Positives = 156/344 (45%), Gaps = 41/344 (11%)
Query: 3493 CPDDFRTLQLSGSTYC-MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCPQ 3550
C +D L S C C+ + F C N CI WKCDG+++C DGSDE A C +
Sbjct: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH-CIHERWKCDGEEECPDGSDESEATCTK 124
Query: 3551 RFCRLGQFQC--SDGNCTSPQTLCNAHQNCPDGSDED--RLLCENHHCDSNEWQCANKRC 3606
+ C + C + C C+ ++C G+DE LC H E+QC N+ C
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPH-----EFQCGNRSC 179
Query: 3607 IPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC---ANGRCIPQAWKCDVDNDCGDH 3663
+ + CD +DC D SDE CA C P +FRC G CIP+ W CD DC D
Sbjct: 180 LAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
Query: 3664 SDEPIEEC-------MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEE 3716
SDE E C S+ C ++F+C++ C+ C+G DC+D SDE C
Sbjct: 238 SDEAAELCGRPGPGATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPL 296
Query: 3717 RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAP--RECTESEFRC-------- 3766
TC +F+C + C+ C+ + DC D SDE C EC + C
Sbjct: 297 GTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK 355
Query: 3767 VNQQC-IPSRWICDHYNDCGDNSDERD----CEMRTCHPEYFQC 3805
+ +C P+ + CGD + +D ++ + YF+C
Sbjct: 356 IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC 399
Score = 168 bits (425), Expect = 1e-40
Identities = 114/406 (28%), Positives = 193/406 (47%), Gaps = 66/406 (16%)
Query: 2344 NPCLENNGGCSHLCFALP-GLHTPKCDCAFGTLQSDGKNCA------------------- 2383
N CL NNGGCSH+C L G +C C G D K C
Sbjct: 338 NECLHNNGGCSHICTDLKIGF---ECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
Query: 2384 --------------ISTENF---------LIFALSNSLRSLHLDPENHSPPFQTINVERT 2420
+ T+N LIF + +R + L N+S + I + +
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKN 451
Query: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
V++LD + ++RIY+ + S +I + + +G+A DW+ + I
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 2481 YYSDYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLG 2538
Y++D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
Query: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHA 2595
G R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
Query: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
FG+ ++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + C
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDAC 690
Query: 2656 E---QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
E Q NGGC ++C P P + C CP +L + K C
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 734
Score = 162 bits (411), Expect = 6e-39
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 384 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
Query: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 443 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 492
Query: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 493 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
Query: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 611 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 668
Query: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 669 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 720
Score = 136 bits (343), Expect = 4e-31
Identities = 89/259 (34%), Positives = 118/259 (45%), Gaps = 31/259 (11%)
Query: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
CEG C F C N C+ ++CDG DDC D SDE+ C + C F
Sbjct: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREF 211
Query: 1073 TC---GHGECIPAHWRCDKRNDCVDGSDE--HNC------PTHAPASCLD-TQYTCDNHQ 1120
C G G CIP W CD++ DC D SDE C T APA+C +Q+ C + +
Sbjct: 212 RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE 271
Query: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
C+ W CD D DC D SDE +C TC+ +F C + C+ C+ ++DC DGSDE
Sbjct: 272 CVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 1181 VGCV--LN-CTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC 1230
GC+ LN C + C+ D IG C F D DE P +C
Sbjct: 331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
Query: 1231 --HSDEFQCQEDGICIPNF 1247
+ F+C+ C P +
Sbjct: 391 VNYKGYFKCE----CYPGY 405
Score = 135 bits (339), Expect = 1e-30
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 386 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 439
Query: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 440 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
Query: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 498 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 549
Query: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 550 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 605
Query: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 606 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 665
Query: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 666 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
Query: 2050 KLNPDNRSC 2058
L PD + C
Sbjct: 726 WLGPDMKRC 734
Score = 110 bits (275), Expect = 3e-23
Identities = 55/162 (33%), Positives = 75/162 (46%), Gaps = 38/162 (23%)
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
+ C +++F C CIP ++RCD +DC D+SDE C +TC + FTC NG CI + +
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3051 CDEDNDCGDGSDELMHLC----------------HTPEPT-------------------- 3074
CD + +C DGSDE C H P
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3075 --CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINEC 3114
C PHEF+C N C+ + +C+ DDC D SDE+GC C
Sbjct: 165 TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC 206
Score = 86.7 bits (213), Expect = 5e-16
Identities = 56/162 (34%), Positives = 77/162 (47%), Gaps = 25/162 (15%)
Query: 3504 GSTYCMPMCSS-TQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD 3562
G+T C++ +QF C + E C+ + W+CDG +DC D SDE A CP CR +FQC D
Sbjct: 251 GATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQCGD 308
Query: 3563 GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCAN---------KRCIPESWQ- 3612
G C CN Q+CPDGSDE L + C N C++ + P +Q
Sbjct: 309 GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL 368
Query: 3613 -----CDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIP 3649
C ++C+D D S C + G F+C C P
Sbjct: 369 LDQKTCGDIDECKD-PDACSQICVN---YKGYFKC---ECYP 403
Score = 75.5 bits (184), Expect = 1e-12
Identities = 58/172 (33%), Positives = 72/172 (41%), Gaps = 27/172 (15%)
Query: 1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC-LGHNICVN 1327
K C F C N CI W CD D+DC D SDE DCP + C + C GH C++
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGH--CIH 100
Query: 1328 LSVVCDGIFDCPNGTDES-PLCNGNSCSDFNGGC---THECVQEPFGAKCLCPLGFLLAN 1383
CDG +CP+G+DES C C C +H+CV P +C +
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV--PASWRC---------D 149
Query: 1384 DSKTCE-DIDECDILGSCSQH---CYN---MRGSFRCSCDTGYMLESDGRTC 1428
K CE DE C+ H C N + F C D SD R C
Sbjct: 150 GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 37.4 bits (85), Expect = 0.35
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)
Query: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678
NQ+Q C N C NGGCSHIC G EC CP
Sbjct: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Score = 33.1 bits (74), Expect = 6.6
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 347 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 402
Query: 4391 FD-ETDL--PKCKCPSG 4404
E DL CK +G
Sbjct: 403 PGYEMDLLTKNCKAAAG 419
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 487 bits (1253), Expect = e-136
Identities = 265/704 (37%), Positives = 376/704 (53%), Gaps = 60/704 (8%)
Query: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCAS--GRCIPQ 2879
C+ +C + CI ++CDG +C D SDE+ C + TC S +F C RCIPQ
Sbjct: 27 CERNEFQCQDGK-CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK 2939
W CD + DC + SDE G +TC DEF+C G+CI +++CD D DC D SDE
Sbjct: 86 FWRCDGQVDCDNGSDEQ---GCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
Query: 2940 RHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE-NQNCT--------R 2990
C C + F C + CIPQ W CD D DC DG DE Q C
Sbjct: 143 ---CPVLTCGPASFQCNSST-----CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDS 194
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
CS EF C G CI +RCD DC D SDE C TC+ ++F C +G CI +
Sbjct: 195 SPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQ 254
Query: 3051 CDEDNDCGDGSDEL----MHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
CD + DC D SDE+ + LC P ++FKC +G CI + K+CN DC D SDE
Sbjct: 255 CDREYDCKDMSDEVGCVNVTLCEGP------NKFKCHSGECITLDKVCNMARDCRDWSDE 308
Query: 3107 --KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCS 3164
K CG NEC D + GC H C D + C C G++L++ +R C DIDEC + P CS
Sbjct: 309 PIKECGTNECLDNN-GGCSHVCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-PDTCS 365
Query: 3165 QKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILE 3224
Q C N+ G Y C+C G+ +P K C+ +I YL F+NR+ +R +T+D Y+ ++
Sbjct: 366 QLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIA-YLFFTNRHEVRKMTLDRSEYTSLIP 424
Query: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNK----TNKETIINHRLPAAESLAVDWV 3280
L NVVALD + R+YW D +++I L++ ++ +T+I+ + A + LAVDW+
Sbjct: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWI 484
Query: 3281 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 3340
+YW D+ L + V+D G R+ L + N + PR + + P +G++YW DW
Sbjct: 485 HSNIYWTDSVLGTVSVADTKGVKRKTLFRE----NGS----KPRAIVVDPVHGFMYWTDW 536
Query: 3341 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 3400
G A I + G++G + +++ ++WPNGIT+D + LYW D+ L I D+ G +R
Sbjct: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
Query: 3401 TVYDG--ALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYH 3458
T+ + L HPF++ +FED ++WTD + N+ GS+ L P D+ ++H
Sbjct: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
Query: 3459 PYRQPIVSNPC---GTNNGGCSHLCL----IKPGGKGFTCECPD 3495
QP N C +NGGC +LCL I P FTC CPD
Sbjct: 657 NLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Score = 449 bits (1154), Expect = e-125
Identities = 255/721 (35%), Positives = 366/721 (50%), Gaps = 55/721 (7%)
Query: 1063 LNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDN--HQ 1120
+ + C + F C G+CI W CD +C DGSDE T +C ++C ++
Sbjct: 23 VGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ-ETCLSVTCKSGDFSCGGRVNR 81
Query: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
CI + W CD DC +GSDE+ C +TC +F C + +CI FVCD D+DC+DGSDE
Sbjct: 82 CIPQFWRCDGQVDCDNGSDEQGC-PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
Query: 1181 VGC-VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGM---------C 1230
C VL C + F+C S CI CD DC D SDE P R G+ C
Sbjct: 141 ASCPVLTCGPASFQCNSST-CIPQLWACDNDPDCEDGSDE--WPQRCRGLYVFQGDSSPC 197
Query: 1231 HSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLC 1290
+ EF C G CI + W CDG PDC SDE N C TC F C +GNCIH + C
Sbjct: 198 SAFEFHCLS-GECIHSSWRCDGGPDCKDKSDEEN-CAVATCRPDEFQCSDGNCIHGSRQC 255
Query: 1291 DRDNDCGDMSDEKDCPT-------QPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTD 1343
DR+ DC DMSDE C F+C S + C+ L VC+ DC + +D
Sbjct: 256 DREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGE--------CITLDKVCNMARDCRDWSD 307
Query: 1344 ESPL--CNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCS 1401
E P+ C N C D NGGC+H C G +CLCP GF L + CEDIDEC +CS
Sbjct: 308 E-PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQDPDTCS 365
Query: 1402 QHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL 1461
Q C N+ G ++C C+ G+ L+ + CK S + L N+ +T SL
Sbjct: 366 QLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFT---NRHEVRKMTLDRSEYTSL 422
Query: 1462 VENGSYIVAVDFDSISGRIFWSDATQGKTWSA----FQNGTDRRVVFDSSIILTETIAID 1517
+ N +VA+D + S RI+WSD +Q S + V I + +A+D
Sbjct: 423 IPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVD 482
Query: 1518 WVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHP 1577
W+ N+YWTD L T+ V+ G R L +N + PR + +DP ++W+DWG
Sbjct: 483 WIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHG--FMYWTDWGTPA 540
Query: 1578 RIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIA 1637
+I++ ++G +V + I WP G+T+D + LY++DS L + D NG +R+ ++
Sbjct: 541 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE 600
Query: 1638 SDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQ 1697
+ + HP++L +FED V+WTD + AN+ G + +++ N+ P +V H Q
Sbjct: 601 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ 660
Query: 1698 PNSVNPC-----AFSRCSHLCLLSSQ-GPHF--YSCVCPSGWSLSPDLLNCLRDDQPFLI 1749
P VN C + C +LCL + Q PH ++C CP G L+ D+ +CL + + +
Sbjct: 661 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA 720
Query: 1750 T 1750
T
Sbjct: 721 T 721
Score = 425 bits (1093), Expect = e-118
Identities = 243/718 (33%), Positives = 364/718 (50%), Gaps = 48/718 (6%)
Query: 16 LVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGYFK 73
L+A A G C+ F+C G CI W CDG+ +C D +DE C VTC+ G F
Sbjct: 15 LLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFS 74
Query: 74 CQSE-GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRD 132
C +CIP W CD DCD+GSDE Q C TCS + C +G+CI ++ CD RD
Sbjct: 75 CGGRVNRCIPQFWRCDGQVDCDNGSDE-QGCPPKTCSQDEFRCHDGKCISRQFVCDSDRD 133
Query: 133 CPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEI--NCTEI------ 182
C DG+DE C TC C++ C CD DC D SDE C +
Sbjct: 134 CLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGD 193
Query: 183 ---CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNW 239
C EF C +GECI ++ CD DC+D SDE C TC +F C G CI+ +
Sbjct: 194 SSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSR 253
Query: 240 VCDGEDDCKDNGDEDGCESGPHDVHKCS-PREWSCPESGRCISIYKVCDGILDCPGREDE 298
CD E DCKD DE GC + V C P ++ C SG CI++ KVC+ DC DE
Sbjct: 254 QCDREYDCKDMSDEVGCVN----VTLCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDE 308
Query: 299 NNTSTGKYCSMTLCSALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWG 356
K C C N C + C++ G C CP G+ + R C + D+CQ
Sbjct: 309 PI----KECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ--RRCEDIDECQDPD 362
Query: 357 ICDQKCESRPGRHLCHCEEGYILE-RGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFR 415
C Q C + G + C CEEG+ L+ + CKA S A + F+N ++ + +
Sbjct: 363 TCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSI--AYLFFTNRHEVRKMTLDRSEYT 420
Query: 416 ILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLN----IQEVLNVSVETPEN 471
L+ + VA+ + R++W+D Q + S ++ + V++ ++ P+
Sbjct: 421 SLIPNLRNVVALDTEVASN--RIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWES 531
LAVDW+++ IY ++ + + + + G R TL EN PR I VDP G+++++DW
Sbjct: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW-- 536
Query: 532 LSGEP-KLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQ 590
G P K+++ ++G + LV + WP G+TLD++S R+YWVDS+ I ++ +G
Sbjct: 537 --GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGN 594
Query: 591 RKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTV 650
RKT++ + HPF +++FE +VF+TD A+ AN+ T ++ + + L P + +
Sbjct: 595 RKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL 654
Query: 651 YHSLRQPYATNPCKD---NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705
+H+L QP N C+ +NGGC+ +C+ + + + F C C G L D R C+
Sbjct: 655 FHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
Score = 388 bits (996), Expect = e-107
Identities = 246/728 (33%), Positives = 358/728 (49%), Gaps = 78/728 (10%)
Query: 3683 EFSCKTNYRCIPKWAVCNGVDDCRDNSDE--QGCEERTCHPVGDFRC--KNHHCIPLRWQ 3738
EF C+ +CI VC+G +C+D SDE + C TC GDF C + + CIP W+
Sbjct: 31 EFQCQDG-KCISYKWVCDGSAECQDGSDESQETCLSVTCKS-GDFSCGGRVNRCIPQFWR 88
Query: 3739 CDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTC 3798
CDGQ DC + SDE+ C P+ C++ EFRC + +CI +++CD DC D SDE C + TC
Sbjct: 89 CDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTC 148
Query: 3799 HPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTR-----FPDGAYCQATMFECKNHV 3853
P FQC S C+ CD DC D SDE R D + C A F C +
Sbjct: 149 GPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGE 208
Query: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT 3913
CI W+CDG DC D SDEE C C P+ F+C + CI+ C+ DC D +
Sbjct: 209 CIHSSWRCDGGPDCKDKSDEE--NCAVATCR-PDEFQCSDGNCIHGSRQCDREYDCKDMS 265
Query: 3914 DE----TEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSD----ELGCNKG 3965
DE C P ++KC +G CI D VC+ A DC DWSD E G N+
Sbjct: 266 DEVGCVNVTLCEGPN-------KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNE- 317
Query: 3966 KERTCAENI--CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRN 4023
C +N C C L + G+ C C GF+ + + C DI+EC+ TC Q C N
Sbjct: 318 ----CLDNNGGCSHVCNDL-KIGYECLCPDGFQ--LVAQRRCEDIDECQDPDTCSQLCVN 370
Query: 4024 TKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEY 4083
+G Y+C C +GF D K C A GS L + +RK L ++ + +
Sbjct: 371 LEGGYKCQCEEGF--QLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRN 428
Query: 4084 IQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKL-KYVM 4142
+ A+D ++ + +Y++ + + I + + R + V D + + +
Sbjct: 429 VVALD-----TEVASNRIYWS---------DLSQRMICSTQLDRAHGVSSYDTVISRDIQ 474
Query: 4143 QPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWT 4202
PDG+AVDW+ +IYW+D + VA G RK L + +P AI V+P G M+WT
Sbjct: 475 APDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT 534
Query: 4203 DWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
DWG KI+ +NG D LV E++ WP G+++D L+ R+YW D K I +I +G
Sbjct: 535 DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSG-RLYWVDSKLHSISSIDVNGG 593
Query: 4263 DRRVI---AKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQ-V 4318
+R+ I K +P+SL +FED+++W ++ N+ G L N + +
Sbjct: 594 NRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRL-TGSDVNLLAENLLSPEDM 652
Query: 4319 RIFHQLRYNKSVPNLCKQI------CSHLCLLRP------GGYSCACPQG---SSFIEGS 4363
+FH L + V N C++ C +LCL P ++CACP G + +
Sbjct: 653 VLFHNLTQPRGV-NWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Query: 4364 TTECDAAI 4371
TE +AA+
Sbjct: 712 LTEAEAAV 719
Score = 239 bits (610), Expect = 5e-62
Identities = 186/636 (29%), Positives = 273/636 (42%), Gaps = 82/636 (12%)
Query: 2697 GERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCAN--GRCV 2754
G+RC + F C +G+CIS +W CD +C DGSDE + C TC F+C RC+
Sbjct: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCI 83
Query: 2755 QYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDE 2814
+RCD DC +GSDE GC + C + EF C++ +CI R+F+C+ +C D SDE
Sbjct: 84 PQFWRCDGQVDCDNGSDEQGCPPKTC-SQDEFRCHDGKCISRQFVCDSDRDCLDG--SDE 140
Query: 2815 KNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYC--------TTHTCSS 2866
+CP TC +C NS+ CIP+++ CD D DC D SDE P C + CS+
Sbjct: 141 ASCPVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSA 199
Query: 2867 SEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICD 2926
EF C SG CI W CD DC D SDE +C + TC DEF+C G CI CD
Sbjct: 200 FEFHCLSGECIHSSWRCDGGPDCKDKSDE-ENC--AVATCRPDEFQCSDGNCIHGSRQCD 256
Query: 2927 GDNDCGDMSDEDKRHQCQNQNCSD--SEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE 2984
+ DC DMSDE C N + ++F C + CI VC+ DC D DE
Sbjct: 257 REYDCKDMSDE---VGCVNVTLCEGPNKFKCHSG-----ECITLDKVCNMARDCRDWSDE 308
Query: 2985 N-QNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGR 3043
+ C C +N C + C D CL C +G
Sbjct: 309 PIKECGTNECLDNNGGCSH--------------VCNDLKIGYECL----------CPDGF 344
Query: 3044 CISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDN 3103
+ C++ ++C D D LC E +KC +C E +L H C
Sbjct: 345 QLVAQRRCEDIDECQD-PDTCSQLCVNLE-----GGYKC---QCEEGFQLDPHTKACKAV 395
Query: 3104 SDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVC 3163
H+ D + TS + R L ++ + +C
Sbjct: 396 GSIAYLFFTNRHEVRKMTLDRS---EYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMIC 452
Query: 3164 SQKCENVIG-SYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL--------TI 3214
S + + G S ++ PDG + I SN Y+ ++ T
Sbjct: 453 STQLDRAHGVSSYDTVISRDIQAPDG--------LAVDWIHSNIYWTDSVLGTVSVADTK 504
Query: 3215 DGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQV-IERMFLNKTNKETIINHRLPAAE 3273
+L E A+ D V +YW D I++ LN + +++ +
Sbjct: 505 GVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564
Query: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQ 3309
+ +D +S +LYW+D++L + D+NGG+R+ + +
Sbjct: 565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE 600
Score = 218 bits (555), Expect = 1e-55
Identities = 135/417 (32%), Positives = 190/417 (45%), Gaps = 73/417 (17%)
Query: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK--RCIPES 3610
C +FQC DG C S + +C+ C DGSDE + C + C S ++ C + RCIP+
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 3611 WQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE---P 3667
W+CD DC++ SDE C +TC +FRC +G+CI + + CD D DC D SDE P
Sbjct: 87 WRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP 144
Query: 3668 IEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDE--QGC--------EER 3717
+ C ++ C++ T CIP+ C+ DC D SDE Q C +
Sbjct: 145 VLTCGPASFQCNSST---------CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
Query: 3718 TCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWI 3777
C +F C + CI W+CDG DC D SDEENCA C EF+C + CI
Sbjct: 196 PCSAF-EFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQ 254
Query: 3778 CDHYNDCGDNSDERDC-EMRTCH-PEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTR 3835
CD DC D SDE C + C P F+C SG C+ + C+ + DC D SDE
Sbjct: 255 CDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE------ 308
Query: 3836 FPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPNRFRC 3891
P +C G ++C D + H+C D+ C P+ F+
Sbjct: 309 ---------------------PIKEC-GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ- 345
Query: 3892 DNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCI-PHDNVC 3947
+ + C +D+C D + C + Y+ +C G + PH C
Sbjct: 346 -----LVAQRRCEDIDECQD-----PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKAC 392
Score = 196 bits (499), Expect = 3e-49
Identities = 117/336 (34%), Positives = 156/336 (46%), Gaps = 29/336 (8%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQRFCRLGQFQCSD--GNCTSP 3568
C +F C + KCI W CDG +C DGSDE C C+ G F C C
Sbjct: 27 CERNEFQCQDG-KCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 3569 QTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSS 3628
C+ +C +GSDE C C +E++C + +CI + CD+ DC D SDE S
Sbjct: 86 FWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS- 142
Query: 3629 HCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEEC------MSSAHLCDNFT 3682
C TC P F+C + CIPQ W CD D DC D SDE + C + C F
Sbjct: 143 -CPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAF- 200
Query: 3683 EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQ 3742
EF C + CI C+G DC+D SDE+ C TC P +F+C + +CI QCD +
Sbjct: 201 EFHCLSG-ECIHSSWRCDGGPDCKDKSDEENCAVATCRP-DEFQCSDGNCIHGSRQCDRE 258
Query: 3743 NDCGDNSDEENCAPRECTE--SEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHP 3800
DC D SDE C E ++F+C + +CI +C+ DC D SDE
Sbjct: 259 YDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE---------- 308
Query: 3801 EYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRF 3836
+C + C+ + C + L E CP F
Sbjct: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGF 344
Score = 190 bits (483), Expect = 2e-47
Identities = 125/381 (32%), Positives = 168/381 (44%), Gaps = 49/381 (12%)
Query: 3490 TCECPDDFRTLQLSGSTYCMPMCSSTQFLCANN-EKCIPIWWKCDGQKDCSDGSDELALC 3548
+ EC D Q T C S F C +CIP +W+CDGQ DC +GSDE C
Sbjct: 49 SAECQDGSDESQ---ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQG-C 104
Query: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
P + C +F+C DG C S Q +C++ ++C DGSDE C C +QC + CIP
Sbjct: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE--ASCPVLTCGPASFQCNSSTCIP 162
Query: 3609 ESWQCDTFNDCEDNSDEDSSHCA--------SRTCRPGQFRCANGRCIPQAWKCDVDNDC 3660
+ W CD DCED SDE C S C +F C +G CI +W+CD DC
Sbjct: 163 QLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDC 222
Query: 3661 GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERT-C 3719
D SDE E C + D EF C ++ CI C+ DC+D SDE GC T C
Sbjct: 223 KDKSDE--ENCAVATCRPD---EFQC-SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLC 276
Query: 3720 HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICD 3779
F+C + CI L C+ DC D SDE +EC +E C+ + C
Sbjct: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDE---PIKECGTNE-------CLDNNGGCS 326
Query: 3780 HYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDG 3839
H C D +C C G + ++ +C+ +C D + G
Sbjct: 327 HV--CNDLKIGYEC----------LCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGG 374
Query: 3840 AYCQATMFECKNHVCIPPYWK 3860
CQ C+ + P+ K
Sbjct: 375 YKCQ-----CEEGFQLDPHTK 390
Score = 179 bits (454), Expect = 6e-44
Identities = 114/402 (28%), Positives = 194/402 (48%), Gaps = 53/402 (13%)
Query: 660 TNPCKDNNGGCEQVC-----------------VLSHRTDN-----------------DGL 685
TN C DNNGGC VC V R ++ +G
Sbjct: 315 TNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG- 373
Query: 686 GFRCKCTFGFQLDTDERHCIAVQN--FLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFF 743
G++C+C GFQLD + C AV + +L F+++ +R + S ++P N
Sbjct: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS-LIPNLRN---V 429
Query: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDG----TGREILAANRVENVESLAFDWISKNLY 799
V +D + + I++SD+S+ MI ++D + + + + ++ + LA DWI N+Y
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489
Query: 800 WTDSHYKSISVMRLADKTRRTVVQYLNN-PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDG 858
WTDS ++SV R+T+ + + PR++VV P G++++TDW PAKI + +G
Sbjct: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549
Query: 859 SHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIE-QMTHPF 917
+ ++ + WPNG+ +D + RLYWVD+ I +G +R+ + E ++ HPF
Sbjct: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609
Query: 918 GLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSY-DVNIQTGSNACNQ 976
LA+F + +F+TD AI + G ++ ++ + + + ++ G N C +
Sbjct: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCER 669
Query: 977 PTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013
T NG C + C P P + C CP GM LA + +C
Sbjct: 670 TTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 166 bits (420), Expect = 5e-40
Identities = 124/423 (29%), Positives = 188/423 (44%), Gaps = 87/423 (20%)
Query: 2340 EVNNNPCLENNGGCSH---------------------------------------LCFAL 2360
E N CL+NNGGCSH LC L
Sbjct: 312 ECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
Query: 2361 PGLHTPKCDCAFG-TLQSDGKNC-AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
G + KC C G L K C A+ + +L F + +R + LD ++ +
Sbjct: 372 EGGY--KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNL--- 426
Query: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIASGIGTADGIAFDWIT 2477
R V++LD + S+RIY++ +L+ + + + G+ + TVI+ I DG+A DWI
Sbjct: 427 RNVVALDTEVASNRIYWS-DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
Query: 2478 RRIYYSDYLNQMINSMAEDGSNRTVIARV--PKPRAIVLDPCQGYLYWADWDTHAKIERA 2535
IY++D + ++ G R + R KPRAIV+DP G++YW DW T AKI++
Sbjct: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
Query: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIV---NAA 2592
L G +V ++ P+G+TLD LYWVD+ L I + G +R+ I+
Sbjct: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRL 605
Query: 2593 VHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLS-----------QPRGIN 2641
H F L ++ ++WTD+ + I+ AN+ GS + NLLS QPRG+N
Sbjct: 606 AHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN 665
Query: 2642 TVVKNQKQQCNNPCEQ---FNGGCSHICAPGPN------GAECQCPHEGNWYLANNRKHC 2692
CE+ NGGC ++C P P C CP LA + + C
Sbjct: 666 W------------CERTTLSNGGCQYLCLPAPQINPHSPKFTCACP--DGMLLARDMRSC 711
Query: 2693 IVD 2695
+ +
Sbjct: 712 LTE 714
Score = 164 bits (415), Expect = 2e-39
Identities = 111/390 (28%), Positives = 193/390 (49%), Gaps = 24/390 (6%)
Query: 2006 GLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS-- 2063
G Q+ +R E + C + + C Q+C+ + GG + C C GF+L+P ++C S
Sbjct: 343 GFQLVAQRRC-EDIDECQDP-DTCSQLCVNLEGG-YKCQCEEGFQLDPHTKACKAVGSIA 399
Query: 2064 FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNA 2123
++ + +R +L+ S+++ +++P RN + +D +V+S IYW D S +
Sbjct: 400 YLFFTNRHEVRKMTLDRSEYT-SLIPNL---RNVVALDTEVASNRIYWSDLSQRMICSTQ 455
Query: 2124 IRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRV 2183
+ R SS +++ I G+AVDW+ N+Y+T++ + + V R+
Sbjct: 456 LDRAH-GVSSYDTVISRDI--QAPDGLAVDWIHSNIYWTDSVLGT--VSVADTKGVKRKT 510
Query: 2184 LLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDR 2243
L + PR IVVDP + +++W D+G KI++ L+ + LV+E I P G+ +D
Sbjct: 511 LFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDL 570
Query: 2244 SDGYVYWVDDSLDIIARIRINGENSE-VIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQ 2302
G +YWVD L I+ I +NG N + ++ R P+ + VFE+ + W D + IF
Sbjct: 571 LSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFS 630
Query: 2303 ASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPG 2362
A++ ++ +N+ D+ +F QPR +NGGC +LC P
Sbjct: 631 ANR--LTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTL--SNGGCQYLCLPAPQ 686
Query: 2363 L--HTPK--CDCAFGTLQS-DGKNCAISTE 2387
+ H+PK C C G L + D ++C E
Sbjct: 687 INPHSPKFTCACPDGMLLARDMRSCLTEAE 716
Score = 134 bits (337), Expect = 2e-30
Identities = 80/228 (35%), Positives = 107/228 (46%), Gaps = 29/228 (12%)
Query: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE--QLCGTL------NN 1065
+G P CG SF C + C+P + CD DC D SDE Q C L ++
Sbjct: 136 DGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
Query: 1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKN 1125
CS+ F C GECI + WRCD DC D SDE NC A A+C ++ C + CI +
Sbjct: 196 PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC---AVATCRPDEFQCSDGNCIHGS 252
Query: 1126 WVCDTDNDCGDGSDEKNCNSTETCQ-PSQFNCPNHRCIDLSFVCDGDKDCVDGSDEV--- 1181
CD + DC D SDE C + C+ P++F C + CI L VC+ +DC D SDE
Sbjct: 253 RQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE 312
Query: 1182 -----------GC--VLNCTASQFKCASGDKC-IGVTNRCDGVFDCSD 1215
GC V N ++C D + RC+ + +C D
Sbjct: 313 CGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
Score = 130 bits (328), Expect = 2e-29
Identities = 102/368 (27%), Positives = 171/368 (46%), Gaps = 38/368 (10%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ-PFLITVRQHIIFGISLNPEVKS 1767
CS LC+ G Y C C G+ L P C +L +H + ++L+ +
Sbjct: 364 CSQLCVNLEGG---YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT 420
Query: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG------EIHRVKTDGTNRTVFASISMVG 1821
+ ++P ++N + ++ + A IYW + ++ R + TV S +
Sbjct: 421 S--LIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVI-SRDIQA 475
Query: 1822 PSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPA 1881
P LA+DWI N+Y T+ ++ V G RKTL +G+ P I VDP
Sbjct: 476 PD-GLAVDWIHSNIYWTDSVLGTVSVADTKGV--KRKTLFRENGSK-----PRAIVVDPV 527
Query: 1882 RGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRG 1941
G +YW+D GT PAKI ++G + +L T N++ +TLD+ +LYW +
Sbjct: 528 HGFMYWTDWGT----PAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLH 583
Query: 1942 VIERGNVDGTDRMILVH---QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLR 1998
I +V+G +R ++ +L+HP+ +AV + +++TD E I ++ TG++ +L
Sbjct: 584 SISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLA 643
Query: 1999 DNVPNLRGLQVYHRRNAAESSNGCSN---NMNACQQICLPVP-----GGLFSCACATGFK 2050
+N+ + + ++H N C + CQ +CLP P F+CAC G
Sbjct: 644 ENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGML 703
Query: 2051 LNPDNRSC 2058
L D RSC
Sbjct: 704 LARDMRSC 711
Score = 102 bits (253), Expect = 1e-20
Identities = 53/126 (42%), Positives = 68/126 (53%), Gaps = 8/126 (6%)
Query: 3839 GAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDN--NRC 3896
G C+ F+C++ CI W CDG +C DGSDE CL V C S + F C NRC
Sbjct: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGD-FSCGGRVNRC 82
Query: 3897 IYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDW 3956
I C+G DC +G+D E+ C PK C++ E++C +G CI VCD DC D
Sbjct: 83 IPQFWRCDGQVDCDNGSD--EQGC---PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
Query: 3957 SDELGC 3962
SDE C
Sbjct: 138 SDEASC 143
Score = 98.2 bits (243), Expect = 2e-19
Identities = 62/190 (32%), Positives = 86/190 (45%), Gaps = 17/190 (8%)
Query: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
C G + + C F F C +G C+ + + CDG DC D SDE+ C TC F
Sbjct: 184 CRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVA--TCRPDEF 241
Query: 1073 TCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDN 1132
C G CI +CD+ DC D SDE C + ++ C + +CI+ + VC+
Sbjct: 242 QCSDGNCIHGSRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHSGECITLDKVCNMAR 300
Query: 1133 DCGDGSDE--KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTAS 1190
DC D SDE K C + E C + C +H C DL + C DG V +
Sbjct: 301 DCRDWSDEPIKECGTNE-CLDNNGGC-SHVCNDLKI--GYECLCPDGFQLV--------A 348
Query: 1191 QFKCASGDKC 1200
Q +C D+C
Sbjct: 349 QRRCEDIDEC 358
Score = 61.2 bits (147), Expect = 2e-08
Identities = 45/152 (29%), Positives = 62/152 (40%), Gaps = 22/152 (14%)
Query: 1013 CEGDPTNEPPTEQ-------CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNN 1065
C+G P + +++ C F C +G C+ CD DC D SDE C +
Sbjct: 216 CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTL 275
Query: 1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE--HNCPTHAPASCLDTQYTCDNHQC-- 1121
+ F C GECI C+ DC D SDE C T+ CLD C +H C
Sbjct: 276 CEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN---ECLDNNGGC-SHVCND 331
Query: 1122 ISKNWVCDTDNDCGDGSD---EKNCNSTETCQ 1150
+ + C C DG ++ C + CQ
Sbjct: 332 LKIGYEC----LCPDGFQLVAQRRCEDIDECQ 359
Score = 37.0 bits (84), Expect = 0.46
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Query: 3466 SNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFR 3498
+N C NNGGCSH+C G+ C CPD F+
Sbjct: 315 TNECLDNNGGCSHVC--NDLKIGYECLCPDGFQ 345
Score = 35.8 bits (81), Expect = 1.0
Identities = 15/31 (48%), Positives = 17/31 (54%)
Query: 2648 KQQCNNPCEQFNGGCSHICAPGPNGAECQCP 2678
K+ N C NGGCSH+C G EC CP
Sbjct: 311 KECGTNECLDNNGGCSHVCNDLKIGYECLCP 341
Score = 32.7 bits (73), Expect = 8.6
Identities = 19/68 (27%), Positives = 25/68 (36%), Gaps = 9/68 (13%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLP 4397
CSH+C GY C CP G + E + P C + GG
Sbjct: 325 CSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY--------- 375
Query: 4398 KCKCPSGY 4405
KC+C G+
Sbjct: 376 KCQCEEGF 383
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 481 bits (1239), Expect = e-135
Identities = 324/901 (35%), Positives = 418/901 (46%), Gaps = 138/901 (15%)
Query: 3125 NCTDTLTSFYCSCRPGYKLMSDK--RTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGY 3182
NC+ T + C G+K+ D CV E + + C +GS + GY
Sbjct: 674 NCSCTREDYECDF--GFKMSEDLSLEVCVPDPEFSGKSYSPPVPCP--VGSTYRRTR-GY 728
Query: 3183 LREPDGKTC-------RQNSNIEPY-LIFSNRYYLRNLTIDGYFYSLI--------LEGL 3226
R+ G TC R + P L N + L + Y Y L L GL
Sbjct: 729 -RKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGL 787
Query: 3227 DNVVALDFDRVEKRLYWIDTQRQVIERMFLN-KTNKETIINHRLPAAESLAVDWVSRKLY 3285
VALDFD LYW D VI+R+ LN T +E IIN L E+LA + +S+ LY
Sbjct: 788 RAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLY 847
Query: 3286 WLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH-RA 3344
W+DA + V++ +G R + N+ D PR L L PQ G ++W DWG +
Sbjct: 848 WVDAGFKKIEVANPDGDFRLTIV-------NSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
Query: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
I R MDG+ ++S ++WPNGI++D + +YW DA+L IE G R + D
Sbjct: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD 958
Query: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPI 3464
LPHP+AI +F++ IYW DW+ ++ + +KY GS + L N D+ +++ +
Sbjct: 959 N-LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNT- 1016
Query: 3465 VSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQL-SGSTYC--------------- 3508
SN C CS LCL K +C CP+D + L SG C
Sbjct: 1017 GSNACVPRP--CSLLCLPKANNSR-SCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVK 1073
Query: 3509 -MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG-QFQCSD-GNC 3565
C Q+ C+N IWW CD DC D SDE CP C L QF+C + G C
Sbjct: 1074 EENTCLRNQYRCSNGNCINSIWW-CDFDNDCGDMSDERN-CPTTICDLDTQFRCQESGTC 1131
Query: 3566 TSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
C+ +C D SDE CE H C S+E+ C++ CI SW CD NDC D SDE
Sbjct: 1132 IPLSYKCDLEDDCGDNSDESH--CEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Query: 3626 DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEEC-------------- 3671
+ TC F+C NG CIPQ W CD D DC D SDE C
Sbjct: 1190 ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTC 1249
Query: 3672 -MSSAH------------------LCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
SS H LC +F +F CK +C+ VC+G+ CRD SDE
Sbjct: 1250 IPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDED 1309
Query: 3713 ----GCEE-----RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC-----APRE 3758
GC + + C G F+C+N CI L W+CDG +DCGD SDE NC AP
Sbjct: 1310 AAFAGCSQDPEFHKVCDEFG-FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNC 1368
Query: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC-----------EMRTCHPEYFQCTS 3807
+FRC N CIP+RW CD NDCGD SDE+DC TC P Y++C+S
Sbjct: 1369 SRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSS 1428
Query: 3808 GHCVHSELKCDGSADCLDASDEADCPTRFPDGA--------YCQATMFEC-KNHVCIPPY 3858
G CV CDG DC D SDE CP A C FEC + CIP +
Sbjct: 1429 GTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNW 1488
Query: 3859 WKCDGDDDCGDGSDE---ELHLCLDVPCNSPNRFRC-DNNRCIYSHEVCNGVDDCGDGTD 3914
+CDG DC DG DE H L C S F+C D CI E C+G DC D +D
Sbjct: 1489 KRCDGHQDCQDGRDEANCPTHSTL--TCMS-REFQCEDGEACIVLSERCDGFLDCSDESD 1545
Query: 3915 E 3915
E
Sbjct: 1546 E 1546
Score = 396 bits (1017), Expect = e-109
Identities = 263/788 (33%), Positives = 385/788 (48%), Gaps = 93/788 (11%)
Query: 2382 CAISTEN-FLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLA 2440
C ++ EN F+++A+ S+ D + + + R ++LD+D + +Y++ +LA
Sbjct: 752 CPLAEENEFILYAVRKSI--YRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWS-DLA 808
Query: 2441 SGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR 2500
V I L+ +I SG+ T + +AF+ +++ +Y+ D + I DG R
Sbjct: 809 LDV--IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Query: 2501 TVIAR---VPKPRAIVLDPCQGYLYWADW-DTHAKIERATLGGNFRVPIVNSSLVMPSGL 2556
I + +PRA+VL P +G ++W DW D I R+ + G+ +V+ + P+G+
Sbjct: 867 LTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGI 926
Query: 2557 TLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 2616
++D + +YW DA L+ IER T +G R VI++ H + + ++ IYW D I+
Sbjct: 927 SVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIF 984
Query: 2617 RANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGA-EC 2675
RA+KY GS Q+ + N L+ + K K +N C CS +C P N + C
Sbjct: 985 RASKYSGS-QMEILANQLTGLMDMKIFYKG-KNTGSNAC--VPRPCSLLCLPKANNSRSC 1040
Query: 2676 QCPHE----------------GNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKC 2719
+CP + + L NN C+ + C + + CSNG CI+ W C
Sbjct: 1041 RCPEDVSSSVLPSGDLMCDCPQGYQLKNNT--CVKEE-NTCLRNQYRCSNGNCINSIWWC 1097
Query: 2720 DNDNDCGDGSDEMESVCALHTCS-PTAFTC-ANGRCVQYSYRCDYYNDCGDGSDEAGCLF 2777
D DNDCGD SDE C C T F C +G C+ SY+CD +DCGD SDE+ C
Sbjct: 1098 DFDNDCGDMSDERN--CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEM 1155
Query: 2778 RDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPD--RTCQSGYTKCHNSNIC 2835
C + E+ C++ CI ++C+G ++C D SDE NC TC++ +C N + C
Sbjct: 1156 HQCR-SDEYNCSSGMCIRSSWVCDGDNDCRD--WSDEANCTAIYHTCEASNFQCRNGH-C 1211
Query: 2836 IPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
IP+ + CDGD DC D SDE+P C + F+C +G CIP +CD DC D SDE
Sbjct: 1212 IPQRWACDGDTDCQDGSDEDPVNCEK---KCNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1268
Query: 2896 PASCGHSERTCL-ADEFKC-DGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQN------ 2947
H E C +F C + +C+ +CDG C D SDED +Q+
Sbjct: 1269 Q----HCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKV 1324
Query: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSEN-----EFTCGY 3002
C + F C N CI W CDG DC D Y + NC T + N +F C
Sbjct: 1325 CDEFGFQCQNG-----VCISLIWKCDGMDDCGD-YSDEANCENPTEAPNCSRYFQFRCEN 1378
Query: 3003 GLCIPKIFRCDRHNDCGDYSDERGC-----------LYQTCQQNQFTCQNGRCISKTFVC 3051
G CIP ++CDR NDCGD+SDE+ C TC N + C +G C+ T+VC
Sbjct: 1379 GHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVC 1438
Query: 3052 DEDNDCGDGSDE-----LMHLCHTPEPT----CPPHEFKCDNGR-CIEMMKLCNHLDDCL 3101
D DC DGSDE L ++ PT C EF+C + CI K C+ DC
Sbjct: 1439 DGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQ 1498
Query: 3102 DNSDEKGC 3109
D DE C
Sbjct: 1499 DGRDEANC 1506
Score = 364 bits (934), Expect = 1e-99
Identities = 234/708 (33%), Positives = 327/708 (46%), Gaps = 155/708 (21%)
Query: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANRVENVESLAFDWISKNLYWTD 802
V +DFD + + +++SD++ +I + ++G TG+E++ + +E VE+LAF+ +S+ LYW D
Sbjct: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
Query: 803 SHYKSISVMRLADKTRRTVVQ--YLNNPRSVVVHPFAGYLFFTDW--FRPAKIMRAWSDG 858
+ +K I V R T+V L+ PR++V+ P G +F+TDW +P I R+ DG
Sbjct: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG-IYRSNMDG 909
Query: 859 SHLLPVINTTLGWPNGLAID--WAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHP 916
S +++ + WPNG+++D W +YW DAY + IE TF G R + ++ + HP
Sbjct: 910 SAAYHLVSEDVKWPNGISVDDQW----IYWTDAYLECIERITFSGQQRSVI--LDNLPHP 963
Query: 917 FGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQ 976
+ +A+F +++ DW +I R K G +M ++ + + ++ +K + TGSNAC
Sbjct: 964 YAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVP 1023
Query: 977 PTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNG 1036
CS C P N R C CP + S+ + GD + P + KN
Sbjct: 1024 RP-----CSLLCLPKANNSRSCRCPEDV---SSSVLPSGDLMCDCPQ------GYQLKNN 1069
Query: 1037 RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGS 1096
CV NTC + + C +G CI + W CD NDC D S
Sbjct: 1070 TCVKE----------------------ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMS 1107
Query: 1097 DEHNCPTH----------------APAS----------------------CLDTQYTCDN 1118
DE NCPT P S C +Y C +
Sbjct: 1108 DERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSS 1167
Query: 1119 HQCISKNWVCDTDNDCGDGSDEKNCNST-ETCQPSQFNCPNHRCIDLSFVCDGDKDCVDG 1177
CI +WVCD DNDC D SDE NC + TC+ S F C N CI + CDGD DC DG
Sbjct: 1168 GMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDG 1227
Query: 1178 SDE--VGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDE---------------- 1219
SDE V C C F+C +G CI + CDG+ DCSD SDE
Sbjct: 1228 SDEDPVNCEKKCNG--FRCPNG-TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCK 1284
Query: 1220 ----------------------------AGCPTRPP--GMCHSDEFQCQEDGICIPNFWE 1249
AGC P +C FQCQ +G+CI W+
Sbjct: 1285 NRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCISLIWK 1343
Query: 1250 CDGHPDCLYGSDEHNACVPKTCPSS----YFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
CDG DC SDE N P P+ F C+NG+CI W CDR+NDCGD SDEKDC
Sbjct: 1344 CDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Query: 1306 PTQ---------PFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
P C ++C CV + VCDG DC +G+DE
Sbjct: 1404 GDSHILPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDGYRDCADGSDE 1450
Score = 273 bits (697), Expect = 4e-72
Identities = 156/368 (42%), Positives = 191/368 (51%), Gaps = 38/368 (10%)
Query: 3614 DTFNDCEDNSDEDSSHCASR--TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEEC 3671
D DC ++ C TC Q+RC+NG CI W CD DNDCGD SDE C
Sbjct: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNC 1112
Query: 3672 MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHH 3731
++ +CD T+F C+ + CIP C+ DDC DNSDE CE C ++ C +
Sbjct: 1113 PTT--ICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRS-DEYNCSSGM 1169
Query: 3732 CIPLRWQCDGQNDCGDNSDEENCAP--RECTESEFRCVNQQCIPSRWICDHYNDCGDNSD 3789
CI W CDG NDC D SDE NC C S F+C N CIP RW CD DC D SD
Sbjct: 1170 CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSD 1229
Query: 3790 ER--DCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCP---TRFPDGAYCQA 3844
E +CE + C+ F+C +G C+ S CDG DC D SDE C T F D
Sbjct: 1230 EDPVNCEKK-CNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMD------ 1280
Query: 3845 TMFECKNHV-CIPPYWKCDGDDDCGDGSDEELHL--CLDVP-----CNSPNRFRCDNNRC 3896
F CKN C+ CDG C DGSDE+ C P C+ F+C N C
Sbjct: 1281 --FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFG-FQCQNGVC 1337
Query: 3897 IYSHEVCNGVDDCGDGTDETEEHCRKPTPKP-CTEY-EYKCGNGHCIPHDNVCDDADDCG 3954
I C+G+DDCGD +DE +C PT P C+ Y +++C NGHCIP+ CD +DCG
Sbjct: 1338 ISLIWKCDGMDDCGDYSDEA--NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCG 1395
Query: 3955 DWSDELGC 3962
DWSDE C
Sbjct: 1396 DWSDEKDC 1403
Score = 242 bits (618), Expect = 5e-63
Identities = 140/367 (38%), Positives = 184/367 (50%), Gaps = 43/367 (11%)
Query: 1015 GDPTNEPPTE--QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
GD ++E E QC + C +G C+ + ++CDG +DC D SDE C + +TC +S F
Sbjct: 1145 GDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF 1204
Query: 1073 TCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDN 1132
C +G CIP W CD DC DGSDE P + C + C N CI + CD
Sbjct: 1205 QCRNGHCIPQRWACDGDTDCQDGSDED--PVNCEKKC--NGFRCPNGTCIPSSKHCDGLR 1260
Query: 1133 DCGDGSDEKNCNSTETCQPSQFNCPN-HRCIDLSFVCDGDKDCVDGSDE----VGCVLN- 1186
DC DGSDE++C T F C N +C+ S VCDG C DGSDE GC +
Sbjct: 1261 DCSDGSDEQHCEPLCT-HFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDP 1319
Query: 1187 -----CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC--PTRPPGMCHSDEFQCQE 1239
C F+C +G CI + +CDG+ DC D SDEA C PT P +F+C E
Sbjct: 1320 EFHKVCDEFGFQCQNG-VCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRC-E 1377
Query: 1240 DGICIPNFWECDGHPDCLYGSDE----------HNACVPKTCPSSYFHCDNGNCIHRAWL 1289
+G CIPN W+CD DC SDE + P TC +Y+ C +G C+ W+
Sbjct: 1378 NGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWV 1437
Query: 1290 CDRDNDCGDMSDEKDC-----------PTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDC 1338
CD DC D SDE+ C PTQ RC ++++C C+ CDG DC
Sbjct: 1438 CDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDC 1497
Query: 1339 PNGTDES 1345
+G DE+
Sbjct: 1498 QDGRDEA 1504
Score = 223 bits (567), Expect = 5e-57
Identities = 129/382 (33%), Positives = 164/382 (42%), Gaps = 89/382 (23%)
Query: 27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQCIPNS 84
+C S + C SG CI + W CDG DC D +DE C + TC+ F+C++ G CIP
Sbjct: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN-GHCIPQR 1215
Query: 85 WVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ- 143
W CD D DC DGSDE + C+ + C NG CIPS CD +RDC DG+DE C+
Sbjct: 1216 WACDGDTDCQDGSDEDPVNCEKKCNGFR--CPNGTCIPSSKHCDGLRDCSDGSDEQHCEP 1273
Query: 144 --------------------------------------YPTCEQ------------LTCD 153
+ C Q C
Sbjct: 1274 LCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ 1333
Query: 154 NGACYNTSQKCDWKVDCRDSSDEINC------TEICLHNEFSCGNGECIPRAYVCDHDND 207
NG C + KCD DC D SDE NC + +F C NG CIP + CD +ND
Sbjct: 1334 NGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDREND 1393
Query: 208 CQDGSDEHAC-----------NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
C D SDE C TC + C SG C+ WVCDG DC D DE+ C
Sbjct: 1394 CGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Query: 257 --------ESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCS 308
S P + +C E+ C + CI +K CDG DC DE N T + +
Sbjct: 1454 PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPT--HST 1511
Query: 309 MTLCSALNCQYQCHETPYGGAC 330
+T S ++QC + G AC
Sbjct: 1512 LTCMSR---EFQCED---GEAC 1527
Score = 218 bits (554), Expect = 1e-55
Identities = 119/301 (39%), Positives = 147/301 (48%), Gaps = 58/301 (19%)
Query: 3715 EERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECT-ESEFRCVNQ-QCI 3772
EE TC +RC N +CI W CD NDCGD SDE NC C +++FRC CI
Sbjct: 1074 EENTCLR-NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCI 1132
Query: 3773 PSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
P + CD +DCGDNSDE CEM C + + C+SG C+ S CDG DC D SDEA+C
Sbjct: 1133 PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Query: 3833 PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD 3892
+ C+A+ F+C+N CIP W CDGD DC DGSDE+ C + CN FRC
Sbjct: 1193 TAIYHT---CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC-EKKCNG---FRCP 1245
Query: 3893 NNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTP--------------------------- 3925
N CI S + C+G+ DC DG+DE +HC
Sbjct: 1246 NGTCIPSSKHCDGLRDCSDGSDE--QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
Query: 3926 -------------------KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGK 3966
K C E+ ++C NG CI CD DDCGD+SDE C
Sbjct: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
Query: 3967 E 3967
E
Sbjct: 1364 E 1364
Score = 215 bits (548), Expect = 7e-55
Identities = 117/286 (40%), Positives = 146/286 (51%), Gaps = 18/286 (6%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQ-QGYFKCQSEGQCIPNSWV 86
C +RC +G+CI + W CD DC D +DE C C F+CQ G CIP S+
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ--Y 144
CD + DC D SDE C C S + CS+G CI S + CD DC D +DE +C Y
Sbjct: 1138 CDLEDDCGDNSDE-SHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIY 1196
Query: 145 PTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE--INCTEICLHNEFSCGNGECIPRAY 200
TCE C NG C CD DC+D SDE +NC + C N F C NG CIP +
Sbjct: 1197 HTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSK 1254
Query: 201 VCDHDNDCQDGSDEHACNYPTCGGY-QFTCPS-GRCIYQNWVCDGEDDCKDNGDED---- 254
CD DC DGSDE C P C + F C + +C++ + VCDG C+D DED
Sbjct: 1255 HCDGLRDCSDGSDEQHCE-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFA 1313
Query: 255 GCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN 300
GC P C + C ++G CIS+ CDG+ DC DE N
Sbjct: 1314 GCSQDPEFHKVCDEFGFQC-QNGVCISLIWKCDGMDDCGDYSDEAN 1358
Score = 206 bits (523), Expect = 6e-52
Identities = 121/330 (36%), Positives = 157/330 (47%), Gaps = 51/330 (15%)
Query: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQD 92
FRC +G CIP+ CDG +DCSD +DE C + F C++ QC+ +S VCD
Sbjct: 1242 FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQ 1301
Query: 93 CDDGSDER---QDCSQ-----STCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQY 144
C DGSDE CSQ C C NG CI ++CD + DC D +DE +C+
Sbjct: 1302 CRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCEN 1361
Query: 145 PT----CE---QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE------------ICLH 185
PT C Q C+NG C KCD + DC D SDE +C + CL
Sbjct: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
Query: 186 NEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC---------NYPT----CGGYQFTCPSG 232
N + C +G C+ +VCD DC DGSDE AC + PT C ++F C
Sbjct: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
Query: 233 RCIYQNWV-CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
+ NW CDG DC+D DE C + H C RE+ C + CI + + CDG LD
Sbjct: 1482 KTCIPNWKRCDGHQDCQDGRDEANCPT--HSTLTCMSREFQCEDGEACIVLSERCDGFLD 1539
Query: 292 CPGREDENNTSTGKYCS--MTLCSALNCQY 319
C DE K CS +T+ N Q+
Sbjct: 1540 CSDESDE------KACSDELTVYKVQNLQW 1563
Score = 199 bits (507), Expect = 4e-50
Identities = 119/318 (37%), Positives = 151/318 (47%), Gaps = 46/318 (14%)
Query: 993 NFQRVCG---CPYGMRLASNHLTCEG-----DPTNEPPTEQ-CGLF-SFPCKNGR-CVPN 1041
N ++ C CP G + S+ C+G D ++E E C F F CKN + C+ +
Sbjct: 1234 NCEKKCNGFRCPNGTCIPSSK-HCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFH 1292
Query: 1042 YYLCDGVDDCHDNSDEQLCGT-------LNNTCSSSAFTCGHGECIPAHWRCDKRNDCVD 1094
+CDG+ C D SDE + C F C +G CI W+CD +DC D
Sbjct: 1293 SMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGD 1352
Query: 1095 GSDEHNC--PTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTE----- 1147
SDE NC PT AP Q+ C+N CI W CD +NDCGD SDEK+C +
Sbjct: 1353 YSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFS 1412
Query: 1148 -----TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL--------------NCT 1188
TC P+ + C + C+ ++VCDG +DC DGSDE C L C
Sbjct: 1413 TPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCD 1472
Query: 1189 ASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFW 1248
+F+C CI RCDG DC D DEA CPT C S EFQC++ CI
Sbjct: 1473 RFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSE 1532
Query: 1249 ECDGHPDCLYGSDEHNAC 1266
CDG DC SDE AC
Sbjct: 1533 RCDGFLDCSDESDE-KAC 1549
Score = 169 bits (429), Expect = 5e-41
Identities = 108/318 (33%), Positives = 148/318 (46%), Gaps = 36/318 (11%)
Query: 92 DCDDGSDERQDC---SQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148
DC G + + ++TC +Q CSNG CI S + CD DC D +DE +C C+
Sbjct: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD 1118
Query: 149 ---QLTC-DNGACYNTSQKCDWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAYVCD 203
Q C ++G C S KCD + DC D+SDE +C C +E++C +G CI ++VCD
Sbjct: 1119 LDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCD 1178
Query: 204 HDNDCQDGSDEHACN--YPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDED--GCESG 259
DNDC+D SDE C Y TC F C +G CI Q W CDG+ DC+D DED CE
Sbjct: 1179 GDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK- 1237
Query: 260 PHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQY 319
KC+ + CP +G CI K CDG+ DC DE + C+ + +
Sbjct: 1238 -----KCN--GFRCP-NGTCIPSSKHCDGLRDCSDGSDEQHCE--PLCTHFMDFVCKNRQ 1287
Query: 320 QC--HETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGY 377
QC H G C G + D+ D + +CD+ C+ G
Sbjct: 1288 QCLFHSMVCDGIIQCRDG---SDEDAAFAGCSQDPEFHKVCDE--------FGFQCQNGV 1336
Query: 378 ILERGQYCKANDSFGEAS 395
+ C D G+ S
Sbjct: 1337 CISLIWKCDGMDDCGDYS 1354
Score = 169 bits (429), Expect = 5e-41
Identities = 108/291 (37%), Positives = 138/291 (47%), Gaps = 44/291 (15%)
Query: 3503 SGSTYCMPMCSS-TQFLCANNEKCIPIWWKCDGQKDCSDGSDE---LALCPQ-----RFC 3553
S +C P+C+ F+C N ++C+ CDG C DGSDE A C Q + C
Sbjct: 1266 SDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVC 1325
Query: 3554 RLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSN-----EWQCANKRCIP 3608
FQC +G C S C+ +C D SDE CEN N +++C N CIP
Sbjct: 1326 DEFGFQCQNGVCISLIWKCDGMDDCGDYSDEAN--CENPTEAPNCSRYFQFRCENGHCIP 1383
Query: 3609 ESWQCDTFNDCEDNSDEDS---SHC------ASRTCRPGQFRCANGRCIPQAWKCDVDND 3659
W+CD NDC D SDE SH TC P +RC++G C+ W CD D
Sbjct: 1384 NRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRD 1443
Query: 3660 CGDHSDEPIEECMSSAHL-----------CDNFTEFSCKTNYRCIPKWAVCNGVDDCRDN 3708
C D SDE E C A++ CD F EF C CIP W C+G DC+D
Sbjct: 1444 CADGSDE--EACPLLANVTAASTPTQLGRCDRF-EFECHQPKTCIPNWKRCDGHQDCQDG 1500
Query: 3709 SDEQGCEER---TCHPVGDFRCKNHH-CIPLRWQCDGQNDCGDNSDEENCA 3755
DE C TC +F+C++ CI L +CDG DC D SDE+ C+
Sbjct: 1501 RDEANCPTHSTLTCMS-REFQCEDGEACIVLSERCDGFLDCSDESDEKACS 1550
Score = 150 bits (379), Expect = 3e-35
Identities = 86/234 (36%), Positives = 114/234 (48%), Gaps = 39/234 (16%)
Query: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT----CQQGY-FKCQS 76
P + CD F+C +G CI W+CDG DC D +DE C T C + + F+C++
Sbjct: 1319 PEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN 1378
Query: 77 EGQCIPNSWVCDQDQDCDDGSDERQDCSQ-----------STCSSHQITCSNGQCIPSEY 125
G CIPN W CD++ DC D SDE+ DC STC + CS+G C+ +
Sbjct: 1379 -GHCIPNRWKCDRENDCGDWSDEK-DCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTW 1436
Query: 126 RCDHVRDCPDGADENDC-------------QYPTCEQLTCD---NGACYNTSQKCDWKVD 169
CD RDC DG+DE C Q C++ + C ++CD D
Sbjct: 1437 VCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQD 1496
Query: 170 CRDSSDEINC----TEICLHNEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHACN 218
C+D DE NC T C+ EF C +GE CI + CD DC D SDE AC+
Sbjct: 1497 CQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACS 1550
Score = 142 bits (358), Expect = 8e-33
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 33/258 (12%)
Query: 2934 MSDEDKRHQCQNQNCSDSEFLCVND--RPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRR 2991
M D + +Q +N C E C+ + R + CI W CD D DC D DE +NC
Sbjct: 1057 MCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE-RNCPTT 1115
Query: 2992 TCS-ENEFTCGY-GLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTF 3049
C + +F C G CIP ++CD +DCGD SDE C C+ +++ C +G CI ++
Sbjct: 1116 ICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSW 1175
Query: 3050 VCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
VCD DNDC D SDE C TC F+C NG CI C+ DC D SDE
Sbjct: 1176 VCDGDNDCRDWSDEAN--CTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE--- 1230
Query: 3110 GINECHDPSISGCDHNCTDTLTSFYC---SCRPGYKLMSDKRTCVDIDE-------CTE- 3158
DP NC F C +C P K R C D + CT
Sbjct: 1231 ------DPV------NCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF 1278
Query: 3159 MPFVCSQKCENVIGSYIC 3176
M FVC + + + S +C
Sbjct: 1279 MDFVCKNRQQCLFHSMVC 1296
Score = 141 bits (355), Expect = 2e-32
Identities = 97/285 (34%), Positives = 128/285 (44%), Gaps = 41/285 (14%)
Query: 128 DHVRDCPDGAD--ENDC--QYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC-T 180
D + DCP G N C + TC Q C NG C N+ CD+ DC D SDE NC T
Sbjct: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPT 1114
Query: 181 EIC-LHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQN 238
IC L +F C +G CIP +Y CD ++DC D SDE C C ++ C SG CI +
Sbjct: 1115 TICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSS 1174
Query: 239 WVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
WVCDG++DC+D DE C + H C + C +G CI CDG DC DE
Sbjct: 1175 WVCDGDNDCRDWSDEANCTA---IYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDE 1230
Query: 299 NNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGIC 358
+ +NC+ +C+ CP G I S+ C DC G
Sbjct: 1231 D--------------PVNCEKKCN------GFRCPNGTCI--PSSKHCDGLRDCSD-GSD 1267
Query: 359 DQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRD 403
+Q CE LC ++ + Q C + + I +G D
Sbjct: 1268 EQHCEP-----LCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
Score = 139 bits (350), Expect = 7e-32
Identities = 84/269 (31%), Positives = 141/269 (52%), Gaps = 13/269 (4%)
Query: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNG-TDRRVVFDSSIILTETIAIDWVGRNLYWTD 1527
VA+DFD ++WSD NG T + V+ +S + E +A + + + LYW D
Sbjct: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
Query: 1528 YALETIEVSKIDGSHR-TVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMD 1585
+ IEV+ DG R T++ S L PR L L P+ E ++FW+DWG P I R++MD
Sbjct: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQ--EGVMFWTDWGDLKPGIYRSNMD 908
Query: 1586 GSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHP 1645
GS +V + + WP G+++D ++ +Y+ D+YL+ ++ ++G R ++ + + HP
Sbjct: 909 GSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHP 963
Query: 1646 YALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCA 1705
YA+ +F++ +YW D + + RA+K+ G ++ + + + + K S N C
Sbjct: 964 YAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS-NACV 1022
Query: 1706 FSRCSHLCLLSSQGPHFYSCVCPSGWSLS 1734
CS LCL + SC CP S S
Sbjct: 1023 PRPCSLLCLPKANNSR--SCRCPEDVSSS 1049
Score = 130 bits (327), Expect = 3e-29
Identities = 63/214 (29%), Positives = 128/214 (59%), Gaps = 9/214 (4%)
Query: 426 AVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVL-NVSVETPENLAVDWVNNKIYLV 484
AV + F Y ++W+D + + + +NG QEV+ N +ET E LA + ++ +Y V
Sbjct: 790 AVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWV 849
Query: 485 ETKVNRIDMVNLDGSYRVTLITEN-LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFM 543
+ +I++ N DG +R+T++ + L PR + + P G +F++DW L +P + R+ M
Sbjct: 850 DAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDL--KPGIYRSNM 907
Query: 544 DGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPH 603
DGS LV + WP G+++D + +YW D+ + IE +T+ G QR ++ +PH
Sbjct: 908 DGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPH 962
Query: 604 PFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV 637
P+ +++F+ ++++ DW+++++ +A+K++ + ++
Sbjct: 963 PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEI 996
Score = 124 bits (310), Expect = 3e-27
Identities = 75/230 (32%), Positives = 126/230 (54%), Gaps = 11/230 (4%)
Query: 4145 DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTD-LDQPAAIAVNPKLGLMFWTD 4203
+ +A + + + +YW D K+IEVA DG +R ++++ LD+P A+ + P+ G+MFWTD
Sbjct: 835 EALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTD 894
Query: 4204 WGK-EPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
WG +P I + M+G LV ED+ WP G+S+D + IYW+D + IE I + G
Sbjct: 895 WGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD---DQWIYWTDAYLECIERITFSGQ 951
Query: 4263 DRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH 4322
R VI +PY++ +F++++YW + +++ +K+ + E L ++IF+
Sbjct: 952 QRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY 1011
Query: 4323 QLRYNKSVPNLC-KQICSHLCLLRP-GGYSCACPQ--GSSFIEGSTTECD 4368
+ + S N C + CS LCL + SC CP+ SS + CD
Sbjct: 1012 KGKNTGS--NACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCD 1059
Score = 111 bits (277), Expect = 2e-23
Identities = 93/312 (29%), Positives = 155/312 (49%), Gaps = 30/312 (9%)
Query: 2062 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
N FI+ ++ +I + +L+ + +P+ G R A+ +D D +YW D + V
Sbjct: 758 NEFILYAVRKSI--YRYDLASGATEQLPLTGL-RAAVALDFDYEHNCLYWSDLALDV--- 811
Query: 2122 NAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYR 2181
I+R+ +GS+ ++ + G V +A + ++ LY+ +A + IEV + +R
Sbjct: 812 --IQRLCLNGSTGQEVIINS-GLETVEALAFEPLSQLLYWVDAGFKK--IEVANPDGDFR 866
Query: 2182 RVLLKVTV-DMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLVSEGIVTPRGL 2239
++ +V D PR +V+ P+ +FW D+G +P I RS +D + LVSE + P G+
Sbjct: 867 LTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGI 926
Query: 2240 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 2299
+VD D ++YW D L+ I RI +G+ VI P PY I VF+N I W D +
Sbjct: 927 SVD--DQWIYWTDAYLECIERITFSGQQRSVIL--DNLPHPYAIAVFKNEIYWDDWSQLS 982
Query: 2300 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 2359
IF+ASK + ++ + + L D+ IF K +N C+ CS LC
Sbjct: 983 IFRASK--YSGSQMEILANQLTGLMDMKIFYK------GKNTGSNACVPR--PCSLLC-- 1030
Query: 2360 LPGLHTPK-CDC 2370
LP + + C C
Sbjct: 1031 LPKANNSRSCRC 1042
Score = 103 bits (257), Expect = 4e-21
Identities = 56/145 (38%), Positives = 72/145 (49%), Gaps = 13/145 (8%)
Query: 1017 PTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT--- 1073
P + P C + C +G CV + ++CDG DC D SDE+ C L N ++S T
Sbjct: 1410 PFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469
Query: 1074 -CGHGE--------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC-DNHQCIS 1123
C E CIP RCD DC DG DE NCPTH+ +C+ ++ C D CI
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529
Query: 1124 KNWVCDTDNDCGDGSDEKNCNSTET 1148
+ CD DC D SDEK C+ T
Sbjct: 1530 LSERCDGFLDCSDESDEKACSDELT 1554
Score = 88.6 bits (218), Expect = 1e-16
Identities = 91/387 (23%), Positives = 165/387 (42%), Gaps = 33/387 (8%)
Query: 1733 LSPDLLNC-LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQY 1791
L +L+ C L ++ F++ + I+ L +P+ G++ + ++FD
Sbjct: 745 LEGELVPCPLAEENEFILYAVRKSIYRYDL---ASGATEQLPLTGLRAAVALDFDYEHNC 801
Query: 1792 IYWVENPGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTL 1850
+YW + + I R+ +G+ S + LA + +S+ LY + + IEV
Sbjct: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
Query: 1851 HGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSV 1910
GD R I N + P + + P G ++W+D G + I +NMDG++
Sbjct: 862 DGDFRLT---IVNSSV---LDRPRALVLVPQEGVMFWTDWGD---LKPGIYRSNMDGSAA 912
Query: 1911 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHD 1970
L + +++ +++D +Q +YW IER G R +++ L HP+ IAV
Sbjct: 913 YHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFK 970
Query: 1971 SFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQ 2030
+ +Y+ D I R K +G+ +L + + L +++++ + SN C C
Sbjct: 971 NEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY-KGKNTGSNACV--PRPCS 1027
Query: 2031 QICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPV 2090
+CLP SC C P++ S S S + M +G+ L+ + T V
Sbjct: 1028 LLCLPKANNSRSCRC-------PEDVSSSVLPSGDL--MCDCPQGYQLK----NNTCVKE 1074
Query: 2091 AGQG-RNALHVDVDVSSGFIYWCDFSS 2116
RN I+WCDF +
Sbjct: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDN 1101
Score = 87.8 bits (216), Expect = 2e-16
Identities = 60/180 (33%), Positives = 84/180 (46%), Gaps = 17/180 (9%)
Query: 1196 SGDKCIGVTNRCDGVFDCS-----DNSDEAGCPTRP------PGMCHSDEFQCQEDGICI 1244
SG + + N+ G+ D N+ C RP P +S +C ED +
Sbjct: 990 SGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPED-VSS 1048
Query: 1245 PNFWECDGHPDCLYGSD-EHNACVPK--TCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSD 1301
D DC G ++N CV + TC + + C NGNCI+ W CD DNDCGDMSD
Sbjct: 1049 SVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD 1108
Query: 1302 EKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCT 1361
E++CPT + Q++C C+ LS CD DC + +DES C + C C+
Sbjct: 1109 ERNCPTTICDLDT-QFRCQESGTCIPLSYKCDLEDDCGDNSDESH-CEMHQCRSDEYNCS 1166
Score = 68.6 bits (166), Expect = 1e-10
Identities = 38/96 (39%), Positives = 45/96 (46%), Gaps = 4/96 (4%)
Query: 9 ACTLLLALVACLAPASGQECDSAHFRCGSGH-CIPADWRCDGTKDCSDDADEIGC---AV 64
AC LL + A P CD F C CIP RCDG +DC D DE C +
Sbjct: 1452 ACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHST 1511
Query: 65 VTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER 100
+TC F+C+ CI S CD DC D SDE+
Sbjct: 1512 LTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEK 1547
Score = 60.8 bits (146), Expect = 3e-08
Identities = 33/82 (40%), Positives = 37/82 (45%), Gaps = 7/82 (8%)
Query: 2699 RCGASSFTCSNGRCISEEWK-CDNDNDCGDGSDEMESVCALH---TCSPTAFTCANGR-C 2753
RC F C + WK CD DC DG DE C H TC F C +G C
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEAN--CPTHSTLTCMSREFQCEDGEAC 1527
Query: 2754 VQYSYRCDYYNDCGDGSDEAGC 2775
+ S RCD + DC D SDE C
Sbjct: 1528 IVLSERCDGFLDCSDESDEKAC 1549
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 403 bits (1035), Expect = e-111
Identities = 209/569 (36%), Positives = 313/569 (55%), Gaps = 38/569 (6%)
Query: 2946 QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLC 3005
++C +F C N+R CIP W CD D DC D DE+ +C ++TC++++FTC G C
Sbjct: 45 KDCEKDQFQCRNER-----CIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
Query: 3006 IPKIFRCDRHNDCGDYSDERG--CLYQTCQQNQFTC--QNGRCISKTFVCDEDNDCGDGS 3061
I + ++CD +C D SDE C Q C + +C + +C+ ++ CD + DC G+
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
Query: 3062 DELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GINECHDPSI 3119
DE C T TC EF+C +G C+ +K CN DC D SDE GC G+NEC +
Sbjct: 159 DEAG--CATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN- 215
Query: 3120 SGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCA 3179
GC H CTD F C+C G++L+ D++TC DIDEC + P CSQ C N G + C+C
Sbjct: 216 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGYFKCECY 273
Query: 3180 PGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEK 3239
PGY + K C+ + P LIF+NR+ +R + + YS ++ L NVVALD +
Sbjct: 274 PGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATN 333
Query: 3240 RLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAESLAVDWVSRKLYWLDARLDGLF 3295
R+YW D + I +++K + +E +I+ +L + E LAVDWV + +YW D+ +
Sbjct: 334 RIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTIS 393
Query: 3296 VSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTN 3355
V+ ++GG RR L + PR +A+ P G++YW+DWG +A I + G++G +
Sbjct: 394 VATVDGGRRRTLFSRNLS--------EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 445
Query: 3356 KSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA--LPHPFAI 3413
+ ++S +EWPNGIT+D + LYW D+ L + D G +R T+ L HPF I
Sbjct: 446 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 505
Query: 3414 TIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTN- 3472
+FED ++WTD + N+ +G L + P DI ++H +QP + C +
Sbjct: 506 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 565
Query: 3473 --NGGCSHLCL----IKPGGKGFTCECPD 3495
NGGC +LCL I +TC CPD
Sbjct: 566 QPNGGCEYLCLPAPQISSHSPKYTCACPD 594
Score = 389 bits (1000), Expect = e-107
Identities = 208/580 (35%), Positives = 315/580 (54%), Gaps = 31/580 (5%)
Query: 1182 GCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG 1241
G +C QF+C + ++CI RCD DC D+SDE CP + C +F C ++G
Sbjct: 42 GPAKDCEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDCPKKT---CADSDFTC-DNG 96
Query: 1242 ICIPNFWECDGHPDCLYGSDEHNA-CVPKTCPSSYFHCD--NGNCIHRAWLCDRDNDCGD 1298
CI W+CDG +C GSDE A C + CP+ C + C+ +W CD + DC
Sbjct: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 1299 MSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG-NSCSDFN 1357
+DE C T C ++QC G CV C+ DCP+G+DE+ G N C N
Sbjct: 157 GADEAGCATSLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN 215
Query: 1358 GGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDT 1417
GGC+H C G +C CP GF L D KTC DIDEC +CSQ C N +G F+C C
Sbjct: 216 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
Query: 1418 GYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYIVAVDFDSI 1476
GY ++ + CK A +S L+ +++++ D V + +++N +VA+D +
Sbjct: 275 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---VVALDVEVA 331
Query: 1477 SGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLYWTDYALET 1532
+ RI+W D + K +SA+ + ++ V+ D + E +A+DWV +++YWTD +T
Sbjct: 332 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 391
Query: 1533 IEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVI 1592
I V+ +DG R L S+NL+ PR +A+DP ++WSDWG +IE++ ++G R +
Sbjct: 392 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGLNGVDRQTL 449
Query: 1593 VQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFE 1652
V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+S + HP+ + +FE
Sbjct: 450 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFE 509
Query: 1653 DSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS----- 1707
D V+WTD + AN+ +G S++ N+ P IV H KQP + + C S
Sbjct: 510 DKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNG 569
Query: 1708 RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRD 1743
C +LCL +SS P Y+C CP L PD+ C RD
Sbjct: 570 GCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRD 608
Score = 329 bits (843), Expect = 4e-89
Identities = 186/578 (32%), Positives = 301/578 (52%), Gaps = 32/578 (5%)
Query: 141 DCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE-ICLHNEFSCGNGECIPRA 199
DC+ +Q C N C + +CD DC D SDE +C + C ++F+C NG CI
Sbjct: 46 DCEK---DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
Query: 200 YVCDHDNDCQDGSDEH--ACNYPTCGGYQFTC--PSGRCIYQNWVCDGEDDCKDNGDEDG 255
+ CD + +C DGSDE C C + +C S +C+ +W CDGE DC+ DE G
Sbjct: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
Query: 256 CESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSAL 315
C + + C E+ C + G C+ K C+ DCP DE G + L +
Sbjct: 163 CATS---LGTCRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG--LNECLHNNG 216
Query: 316 NCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEE 375
C + C + G C CP G+ + D +TC + D+C+ C Q C + G C C
Sbjct: 217 GCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
Query: 376 GYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHY 433
GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+ VA+ V
Sbjct: 275 GYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV--EV 330
Query: 434 HLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVDWVNNKIYLVETKVN 489
R++W D K++S ++ + QEVL + + +PE LAVDWV+ IY ++
Sbjct: 331 ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNK 390
Query: 490 RIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRK 549
I + +DG R TL + NL PR IAVDP G++++SDW + K+E++ ++G +R+
Sbjct: 391 TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQAKIEKSGLNGVDRQ 447
Query: 550 DLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSL 609
LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++ + HPFG+++
Sbjct: 448 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 507
Query: 610 FEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCK---DN 666
FE +VF+TD A+ AN+ + + P+ + ++H L+QP A + C+
Sbjct: 508 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQP 567
Query: 667 NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
NGGCE +C+ + + + + C C L D + C
Sbjct: 568 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 323 bits (829), Expect = 2e-87
Identities = 197/619 (31%), Positives = 310/619 (50%), Gaps = 91/619 (14%)
Query: 3757 RECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELK 3816
++C + +F+C N++CIPS W CD +DC D+SDE DC +TC F C +GHC+H K
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3817 CDGSADCLDASDEADCPTRFPDGAYCQATMFEC--KNHVCIPPYWKCDGDDDCGDGSDEE 3874
CDG +C D SDE++ C A C +H C+P W+CDG+ DC G+DE
Sbjct: 105 CDGEEECPDGSDESEATC---TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3875 LHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYK 3934
C + F+C + C+ + + CN DC DG+DE C +
Sbjct: 162 GCATSLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEA----------GCLQ---- 206
Query: 3935 CGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAG 3994
G C+ ++ C +IC T L G F C+C AG
Sbjct: 207 -GLNECLHNNGGC------------------------SHIC----TDLKIG-FECTCPAG 236
Query: 3995 FETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGSS 4053
F+ + D+ +C DI+EC+ C Q C N KG ++C C G+ D K C AA G S
Sbjct: 237 FQ--LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYE--MDLLTKNCKAAAGKS 292
Query: 4054 PLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFG 4113
P L+ + +R+ +L +S + + + A+D ++ + +Y+
Sbjct: 293 PSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV-----EVATNRIYWCDL------- 340
Query: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173
+ ++ Y + + QEV L + + P+G+AVDWV +HIYW+D NK I VA +DG
Sbjct: 341 SYRKIYSAYMDKASDPKEQEV-LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDG 399
Query: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233
R+ L S +L +P AIAV+P G M+W+DWG + KIE + +NG DR LV +++ WP G
Sbjct: 400 GRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNG 459
Query: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISKE 4290
+++D L + R+YW D K + +I + G +R+ + +P+ + +FED+++W E
Sbjct: 460 ITLDLL-SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLE 518
Query: 4291 KGEVWKQNKFGQGKKEKTL---VVNPWLTQVRIFHQLRYNKSVPNLCKQI------CSHL 4341
++ N+ G + L + NP + IFH+L+ ++ P+ C+ C +L
Sbjct: 519 NEAIFSANRL-NGLEISILAENLNNP--HDIVIFHELKQPRA-PDACELSVQPNGGCEYL 574
Query: 4342 CLLRP------GGYSCACP 4354
CL P Y+CACP
Sbjct: 575 CLPAPQISSHSPKYTCACP 593
Score = 175 bits (443), Expect = 1e-42
Identities = 107/377 (28%), Positives = 189/377 (50%), Gaps = 34/377 (9%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 251 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 303
Query: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 304 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 359
Query: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 419
Query: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 420 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 479
Query: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 480 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 539
Query: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 540 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 595
Query: 1004 MRLASNHLTCEGDPTNE 1020
M L + C D +
Sbjct: 596 MWLGPDMKRCYRDANED 612
Score = 170 bits (431), Expect = 3e-41
Identities = 123/452 (27%), Positives = 207/452 (45%), Gaps = 83/452 (18%)
Query: 2344 NPCLENNGGCSHLCFALP-GLHTPKCDCAFGTLQSDGKNCA------------------- 2383
N CL NNGGCSH+C L G +C C G D K C
Sbjct: 209 NECLHNNGGCSHICTDLKIGF---ECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 265
Query: 2384 --------------ISTENF---------LIFALSNSLRSLHLDPENHSPPFQTINVERT 2420
+ T+N LIF + +R + L N+S + I + +
Sbjct: 266 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKN 322
Query: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
V++LD + ++RIY+ + S +I + + +G+A DW+ + I
Sbjct: 323 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
Query: 2481 YYSDYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLG 2538
Y++D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L
Sbjct: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
Query: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHA 2595
G R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H
Sbjct: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 502
Query: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
FG+ ++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + C
Sbjct: 503 FGIAVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDAC 561
Query: 2656 E---QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHCIVDNGE--RCGAS- 2703
E Q NGGC ++C P P + C CP +L + K C D E + G++
Sbjct: 562 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRCYRDANEDSKMGSTV 619
Query: 2704 --------------SFTCSNGRCISEEWKCDN 2721
+ C +G I WK N
Sbjct: 620 TAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN 651
Score = 162 bits (411), Expect = 6e-39
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 255 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 313
Query: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 314 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 363
Query: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 364 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 421
Query: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 422 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 481
Query: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 482 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 539
Query: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 540 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 591
Score = 151 bits (382), Expect = 1e-35
Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA--NKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEP-----IEECMSS----AHLCDN 3680
+ TCR +F+C +G C+ C+ + DC D SDE + EC+ + +H+C +
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
Query: 3681 FT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIP 3734
E +C ++ + + C +D+C+ D C + + G F+C+ C P
Sbjct: 225 LKIGFECTCPAGFQLLDQ-KTCGDIDECK---DPDACSQICVNYKGYFKCE---CYP 274
Score = 151 bits (382), Expect = 1e-35
Identities = 67/162 (41%), Positives = 93/162 (57%), Gaps = 10/162 (6%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
Query: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1184 VLN---CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
+ C +F+C G C+ C+ DC D SDEAGC
Sbjct: 164 ATSLGTCRGDEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 150 bits (379), Expect = 3e-35
Identities = 77/209 (36%), Positives = 109/209 (52%), Gaps = 28/209 (13%)
Query: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYR 126
C++ F+C++E +CIP+ W CD+D DC D SDE DC + TC+ TC NG CI ++
Sbjct: 47 CEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 127 CDHVRDCPDGADEND--CQYPTC--EQLTC--DNGACYNTSQKCDWKVDCRDSSDEINCT 180
CD +CPDG+DE++ C C E+L+C + C S +CD + DC +DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 181 E---ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC---------NYPTCG----- 223
C +EF CG+G C+ C+ + DC DGSDE C N C
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
Query: 224 ---GYQFTCPSGRCIYQNWVCDGEDDCKD 249
G++ TCP+G + C D+CKD
Sbjct: 225 LKIGFECTCPAGFQLLDQKTCGDIDECKD 253
Score = 144 bits (362), Expect = 3e-33
Identities = 84/241 (34%), Positives = 117/241 (48%), Gaps = 22/241 (9%)
Query: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIP 1081
P + C F C+N RC+P+ + CD DDC D+SDE C TC+ S FTC +G CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIH 100
Query: 1082 AHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSD 1139
W+CD +C DGSDE T C + +C +H+C+ +W CD + DC G+D
Sbjct: 101 ERWKCDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1140 EKNC-NSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCV--LN-CTASQFKCA 1195
E C S TC+ +F C + C+ C+ ++DC DGSDE GC+ LN C + C+
Sbjct: 160 EAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
Query: 1196 --SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC--HSDEFQCQEDGICIPN 1246
D IG C F D DE P +C + F+C+ C P
Sbjct: 220 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE----CYPG 275
Query: 1247 F 1247
+
Sbjct: 276 Y 276
Score = 135 bits (339), Expect = 1e-30
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 257 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 310
Query: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 311 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
Query: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 369 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 420
Query: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 421 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 476
Query: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 477 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 536
Query: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 537 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 596
Query: 2050 KLNPDNRSC 2058
L PD + C
Sbjct: 597 WLGPDMKRC 605
Score = 134 bits (337), Expect = 2e-30
Identities = 82/249 (32%), Positives = 112/249 (44%), Gaps = 39/249 (15%)
Query: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE---PIEECMSSAHLCDNFTEFSCKT 3688
++ C QF+C N RCIP W+CD D+DC DHSDE P + C S CD
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--------- 94
Query: 3689 NYRCIPKWAVCNGVDDCRDNSDEQ--GCEERTCHPVGDFRC--KNHHCIPLRWQCDGQND 3744
N CI + C+G ++C D SDE C ++ C P C +H C+P W+CDG+ D
Sbjct: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKD 153
Query: 3745 CGDNSDEENCAPR--ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEY 3802
C +DE CA C EF+C + C+ + C+ DC D SDE C
Sbjct: 154 CEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL----- 208
Query: 3803 FQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP--DGAYCQATMFECK-----NHVCI 3855
C+H+ C L E CP F D C + ECK + +C+
Sbjct: 209 -----NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC-GDIDECKDPDACSQICV 262
Query: 3856 --PPYWKCD 3862
Y+KC+
Sbjct: 263 NYKGYFKCE 271
Score = 128 bits (322), Expect = 1e-28
Identities = 74/218 (33%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFIC 2800
C F C N RC+ +RCD +DC D SDE C + C A ++F C+N CI + C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTCDNGHCIHERWKC 105
Query: 2801 NGVDNCHDNNTSDEKNCPDRTCQSGYTKCH-NSNICIPRVYLCDGDNDCGDNSDENPTYC 2859
+G + C D + E C + C + C S+ C+P + CDG+ DC +DE
Sbjct: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Query: 2860 TTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCD----- 2914
+ TC EFQC G C+ +C+QE DC D SDE A C CL + C
Sbjct: 166 SLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE-AGCLQGLNECLHNNGGCSHICTD 224
Query: 2915 ---GGRC-IPSEWICDGDNDCGDMSDEDKRHQCQNQNC 2948
G C P+ + CGD+ DE K +Q C
Sbjct: 225 LKIGFECTCPAGFQLLDQKTCGDI-DECKDPDACSQIC 261
Score = 115 bits (288), Expect = 1e-24
Identities = 72/232 (31%), Positives = 101/232 (43%), Gaps = 23/232 (9%)
Query: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
P + C QFQC + C C+ +C D SDED C C +++ C N CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIH 100
Query: 3609 ESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC--ANGRCIPQAWKCDVDNDCGDHSDE 3666
E W+CD +C D SDE + C + C + C + +C+P +W+CD + DC +DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEE--RTC----- 3719
C +S C EF C C+ CN DC D SDE GC + C
Sbjct: 161 --AGCATSLGTCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG 216
Query: 3720 ---HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 3768
H D + P +Q Q CGD + ++ P C++ CVN
Sbjct: 217 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD--PDACSQI---CVN 263
Score = 109 bits (273), Expect = 6e-23
Identities = 78/245 (31%), Positives = 113/245 (46%), Gaps = 41/245 (16%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 2760 CDYYNDCGDGSD--EAGCLFRDCNATTEFMC--NNRRCIPREFICNGVDNCHDNNTSDEK 2815
CD +C DGSD EA C + C A + C + +C+P + C+G +C +DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPA-EKLSCGPTSHKCVPASWRCDGEKDCEGG--ADEA 161
Query: 2816 NCPDR--TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE------------NPTYCTT 2861
C TC+ +C C+ + C+ + DC D SDE N C +
Sbjct: 162 GCATSLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC-S 219
Query: 2862 HTCSSSE--FQCASGRCIPQHWYCDQETDCFDASD--EPASCGHSERTCL--ADEFKCDG 2915
H C+ + F+C C DQ+T C D + +P +C + C+ FKC+
Sbjct: 220 HICTDLKIGFECT---CPAGFQLLDQKT-CGDIDECKDPDAC---SQICVNYKGYFKCE- 271
Query: 2916 GRCIP 2920
C P
Sbjct: 272 --CYP 274
Score = 83.6 bits (205), Expect = 4e-15
Identities = 64/219 (29%), Positives = 81/219 (36%), Gaps = 61/219 (27%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVC----------------------- 2736
C S FTC NG CI E WKCD + +C DGSDE E+ C
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
Query: 2737 --------------------ALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCL 2776
+L TC F C +G CV C+ DC DGSDEAGCL
Sbjct: 146 WRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
Query: 2777 --FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS---DEKNCPDRTCQ----- 2823
+C N +C + + I E C D T DE PD Q
Sbjct: 206 QGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNY 264
Query: 2824 SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862
GY KC C P + +C + ++P+ T+
Sbjct: 265 KGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 299
Score = 72.4 bits (176), Expect = 1e-11
Identities = 52/165 (31%), Positives = 68/165 (41%), Gaps = 15/165 (9%)
Query: 1037 RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGS 1096
+CVP + CDG DC +DE C T TC F CG G C+ A C++ DC DGS
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
Query: 1097 DEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCG-DGSDEKNCNSTETCQP---- 1151
DE C CL C +H C + G D+K C + C+
Sbjct: 200 DEAGC-LQGLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC 257
Query: 1152 SQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCAS 1196
SQ C N++ F C +C G + NC A+ K S
Sbjct: 258 SQI-CVNYKGY---FKC----ECYPGYEMDLLTKNCKAAAGKSPS 294
Score = 48.1 bits (113), Expect = 2e-04
Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 3071 PEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDH 3124
P C +F+C N RCI + C+ DDCLD+SDE C C D + CD+
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT-CDN 95
Score = 37.4 bits (85), Expect = 0.35
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)
Query: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678
NQ+Q C N C NGGCSHIC G EC CP
Sbjct: 190 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 234
Score = 36.6 bits (83), Expect = 0.60
Identities = 17/34 (50%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 3467 NPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
N C NNGGCSH+C GF C CP F+ L
Sbjct: 209 NECLHNNGGCSHICTDLK--IGFECTCPAGFQLL 240
Score = 33.1 bits (74), Expect = 6.6
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 273
Query: 4391 FD-ETDL--PKCKCPSG 4404
E DL CK +G
Sbjct: 274 PGYEMDLLTKNCKAAAG 290
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 379 bits (973), Expect = e-104
Identities = 200/537 (37%), Positives = 294/537 (54%), Gaps = 27/537 (5%)
Query: 1226 PPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
P C D+FQC+ + CIP+ W CD DCL SDE + C KTC S F CDNG+CIH
Sbjct: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIH 100
Query: 1286 RAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC--LGHNICVNLSVVCDGIFDCPNGTD 1343
W CD + +C D SDE + CP+ + C H CV S CDG DC G D
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK-CVPASWRCDGEKDCEGGAD 159
Query: 1344 ESPLCNG-NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQ 1402
E+ N C NGGC+H C G +C CP GF L D KTC DIDEC +CSQ
Sbjct: 160 EAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQ 218
Query: 1403 HCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSL 1461
C N +G F+C C GY ++ + CK A +S L+ +++++ D V + +
Sbjct: 219 ICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM 278
Query: 1462 VENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAID 1517
++N +VA+D + + RI+W D + K +SA+ + ++ V+ D + E +A+D
Sbjct: 279 LKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
Query: 1518 WVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHP 1577
WV +++YWTD +TI V+ +DG R L S+NL+ PR +A+DP ++WSDWG
Sbjct: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQA 393
Query: 1578 RIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIA 1637
+IE++ ++G R +V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+
Sbjct: 394 KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLIS 453
Query: 1638 SDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQ 1697
S + HP+ + +FED V+WTD + AN+ +G S++ N+ P IV H KQ
Sbjct: 454 STDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQ 513
Query: 1698 PNSVNPCAFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745
P + + C S C +LCL +SS P Y+C CP L PD+ C R Q
Sbjct: 514 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 569
Score = 375 bits (964), Expect = e-103
Identities = 195/561 (34%), Positives = 296/561 (52%), Gaps = 30/561 (5%)
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
+ C +++F C CIP ++RCD +DC D+SDE C +TC + FTC NG CI + +
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3051 CDEDNDCGDGSDELMHLCHTPEPTCPPHEFKC--DNGRCIEMMKLCNHLDDCLDNSDEKG 3108
CD + +C DGSDE C + CP + C + +C+ C+ DC +DE G
Sbjct: 105 CDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
Query: 3109 CG--INECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK 3166
C +NEC + GC H CTD F C+C G++L+ D++TC DIDEC + P CSQ
Sbjct: 163 CATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQI 219
Query: 3167 CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGL 3226
C N G + C+C PGY + K C+ + P LIF+NR+ +R + + YS ++ L
Sbjct: 220 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 279
Query: 3227 DNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAESLAVDWVSR 3282
NVVALD + R+YW D + I +++K + +E +I+ +L + E LAVDWV +
Sbjct: 280 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 339
Query: 3283 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 3342
+YW D+ + V+ ++GG RR L + PR +A+ P G++YW+DWG
Sbjct: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNL--------SEPRAIAVDPLRGFMYWSDWGD 391
Query: 3343 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTV 3402
+A I + G++G ++ ++S +EWPNGIT+D + LYW D+ L + D G +R T+
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
Query: 3403 YDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 3460
L HPF I +FED ++WTD + N+ +G L + P DI ++H
Sbjct: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511
Query: 3461 RQPIVSNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSGSTYCMPMCS 3513
+QP + C + NGGC +LCL I +TC CPD Y P +
Sbjct: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
Query: 3514 STQFLCANNEKCIPIWWKCDG 3534
ST L + + +P + G
Sbjct: 572 STTTLASTMTRTVPATTRAPG 592
Score = 324 bits (830), Expect = 1e-87
Identities = 176/532 (33%), Positives = 281/532 (52%), Gaps = 24/532 (4%)
Query: 183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCD 242
C ++F C N CIP + CD D+DC D SDE C TC FTC +G CI++ W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 243 GEDDCKDNGDEDGCESGPHDVHKCSPREWSC-PESGRCISIYKVCDGILDCPGREDENNT 301
GE++C D DE C + SC P S +C+ CDG DC G DE
Sbjct: 107 GEEECPDGSDESEATCTKQ---VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 302 STGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQK 361
+T + + L + C + C + G C CP G+ + D +TC + D+C+ C Q
Sbjct: 164 AT--WLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQI 219
Query: 362 CESRPGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVE 419
C + G C C GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+
Sbjct: 220 CVNYKGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP 277
Query: 420 SQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVD 475
VA+ V R++W D K++S ++ + QEVL + + +PE LAVD
Sbjct: 278 MLKNVVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
Query: 476 WVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGE 535
WV+ IY ++ I + +DG R TL + NL PR IAVDP G++++SDW +
Sbjct: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQ 392
Query: 536 PKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVV 595
K+E++ ++G +R+ LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++
Sbjct: 393 AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 452
Query: 596 HGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLR 655
+ HPFG+++FE +VF+TD A+ AN+ + + P+ + ++H L+
Sbjct: 453 SSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK 512
Query: 656 QPYATNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
QP A + C+ NGGCE +C+ + + + + C C L D + C
Sbjct: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 297 bits (761), Expect = 1e-79
Identities = 179/535 (33%), Positives = 278/535 (51%), Gaps = 51/535 (9%)
Query: 3842 CQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHE 3901
C+ F+C+N CIP W+CD DDDC D SDE+ C C + + F CDN CI+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTC-ADSDFTCDNGHCIHERW 103
Query: 3902 VCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWSDE 3959
C+G ++C DG+DE+E C K C + CG + C+P CD DC +DE
Sbjct: 104 KCDGEEECPDGSDESEATCTKQV---CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 3960 LGCNKGKERTCAENI-CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCP 4018
GC N C CT L G F C+C AGF+ + D+ +C DI+EC+ C
Sbjct: 161 AGCATWLNECLHNNGGCSHICTDLKIG-FECTCPAGFQ--LLDQKTCGDIDECKDPDACS 217
Query: 4019 QHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKYNLSSERFSEY 4077
Q C N KG ++C C G+ D K C AA G SP L+ + +R+ +L +S
Sbjct: 218 QICVNYKGYFKCECYPGYEM--DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL 275
Query: 4078 LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLK 4137
+ + + A+D + + + +Y+ + ++ Y + + QEV +
Sbjct: 276 IPMLKNVVALDVE-----VATNRIYWCDL-------SYRKIYSAYMDKASDPKEQEVLID 323
Query: 4138 LKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLG 4197
+ + P+G+AVDWV +HIYW+D NK I VA +DG R+ L S +L +P AIAV+P G
Sbjct: 324 -EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG 382
Query: 4198 LMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 4257
M+W+DWG + KIE + +NG DR LV +++ WP G+++D L + R+YW D K + +I
Sbjct: 383 FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWVDSKLHQLSSI 441
Query: 4258 KYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTL---VV 4311
+ G +R+ + +P+ + +FED+++W E ++ N+ G + L +
Sbjct: 442 DFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGLEISILAENLN 500
Query: 4312 NPWLTQVRIFHQLRYNKSVPNLCKQI------CSHLCLLRP------GGYSCACP 4354
NP + IFH+L+ ++ P+ C+ C +LCL P Y+CACP
Sbjct: 501 NP--HDIVIFHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 552
Score = 175 bits (443), Expect = 1e-42
Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 210 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 262
Query: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 263 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 318
Query: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 319 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 378
Query: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 379 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 438
Query: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 439 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 498
Query: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 499 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 554
Query: 1004 MRLASNHLTCEGDPTNEPPT 1023
M L + C P + T
Sbjct: 555 MWLGPDMKRCYRAPQSTSTT 574
Score = 168 bits (425), Expect = 1e-40
Identities = 114/406 (28%), Positives = 193/406 (47%), Gaps = 66/406 (16%)
Query: 2344 NPCLENNGGCSHLCFALP-GLHTPKCDCAFGTLQSDGKNCA------------------- 2383
N CL NNGGCSH+C L G +C C G D K C
Sbjct: 168 NECLHNNGGCSHICTDLKIGF---ECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 224
Query: 2384 --------------ISTENF---------LIFALSNSLRSLHLDPENHSPPFQTINVERT 2420
+ T+N LIF + +R + L N+S + I + +
Sbjct: 225 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKN 281
Query: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
V++LD + ++RIY+ + S +I + + +G+A DW+ + I
Sbjct: 282 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
Query: 2481 YYSDYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLG 2538
Y++D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L
Sbjct: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401
Query: 2539 GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHA 2595
G R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H
Sbjct: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 461
Query: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
FG+ ++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + C
Sbjct: 462 FGIAVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDAC 520
Query: 2656 E---QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
E Q NGGC ++C P P + C CP +L + K C
Sbjct: 521 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 564
Score = 162 bits (411), Expect = 6e-39
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 214 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 272
Query: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 273 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 322
Query: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 323 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 380
Query: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 381 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 440
Query: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 441 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 498
Query: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 499 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 550
Score = 149 bits (376), Expect = 6e-35
Identities = 135/525 (25%), Positives = 209/525 (39%), Gaps = 80/525 (15%)
Query: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW 2923
C +FQC + RCIP W CD++ DC D SDE C ++TC +F CD G CI W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DC--PKKTCADSDFTCDNGHCIHERW 103
Query: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
CDG+ +C D SDE + C Q C + C P +C+P SW CDG+ DC G D
Sbjct: 104 KCDGEEECPDGSDESEA-TCTKQVCPAEKLSC---GPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 2984 ENQNCT-RRTCSENEFTCGYGLCIPKI-FRCDRHNDCGDYSDERGCLYQTCQQNQFTCQN 3041
E T C N C + KI F C TC
Sbjct: 160 EAGCATWLNECLHNNGGCSHICTDLKIGFEC-------------------------TCPA 194
Query: 3042 GRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCL 3101
G + C + ++C D D +C + FKC+ EM L
Sbjct: 195 GFQLLDQKTCGDIDECKD-PDACSQICVNYK-----GYFKCECYPGYEMDLL-------- 240
Query: 3102 DNSDEKGCGINECHDPSISGCDHN---CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE 3158
K C PS+ + + D + Y P M +D++ T
Sbjct: 241 ----TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNVVALDVEVATN 292
Query: 3159 MPFVCSQKCENVIGSYICKCA---------PGYLREPDGKTCRQNSNIEPYLIFSNRYYL 3209
+ C + +Y+ K + L P+G + Y S +
Sbjct: 293 RIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAV-DWVHKHIYWTDSGNKTI 351
Query: 3210 RNLTID-GYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQV-IERMFLNKTNKETIINH 3267
T+D G +L L A+ D + +YW D Q IE+ LN +++T+++
Sbjct: 352 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSD 411
Query: 3268 RLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLA 3327
+ + +D +S++LYW+D++L L D +GG+R+ L ++T +P G+A
Sbjct: 412 NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL------ISSTDFLSHPFGIA 465
Query: 3328 LHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
+ ++W D + A ++G S I++ L P+ I I
Sbjct: 466 VFED--KVFWTDLENEAIFSANRLNGLEIS-ILAENLNNPHDIVI 507
Score = 135 bits (339), Expect = 1e-30
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 216 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 269
Query: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 270 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 327
Query: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 328 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 379
Query: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 380 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 435
Query: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 436 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 495
Query: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 496 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 555
Query: 2050 KLNPDNRSC 2058
L PD + C
Sbjct: 556 WLGPDMKRC 564
Score = 127 bits (319), Expect = 3e-28
Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 22/196 (11%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
Query: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 1184 VL---NCTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC--H 1231
C + C+ D IG C F D DE P +C +
Sbjct: 164 ATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNY 223
Query: 1232 SDEFQCQEDGICIPNF 1247
F+C+ C P +
Sbjct: 224 KGYFKCE----CYPGY 235
Score = 122 bits (305), Expect = 1e-26
Identities = 68/192 (35%), Positives = 95/192 (49%), Gaps = 35/192 (18%)
Query: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYR 126
C++ F+C++E +CIP+ W CD+D DC D SDE DC + TC+ TC NG CI ++
Sbjct: 47 CEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 127 CDHVRDCPDGADEND--CQYPTC--EQLTC--DNGACYNTSQKCDWKVDCRDSSDEINCT 180
CD +CPDG+DE++ C C E+L+C + C S +CD + DC +DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 181 ---EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQ 237
CLHN NG C H C G++ TCP+G +
Sbjct: 165 TWLNECLHN-----NGGC------------------SHICTDLKI-GFECTCPAGFQLLD 200
Query: 238 NWVCDGEDDCKD 249
C D+CKD
Sbjct: 201 QKTCGDIDECKD 212
Score = 117 bits (292), Expect = 3e-25
Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 27/194 (13%)
Query: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
++C+ F+C + CIP+ WRCD DC D +DE C TC F C + G CI W
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
Query: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142
CD +++C DGSDE + C++ C + +++C ++ +C+P+ +RCD +DC GADE C
Sbjct: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Query: 143 QYPTCEQLTCDNGACYN--TSQKCDWKVDC---------------RDSSDEINCTEICLH 185
E L +NG C + T K ++ C + D C++IC++
Sbjct: 164 ATWLNECLH-NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN 222
Query: 186 NE--FSCGNGECIP 197
+ F C EC P
Sbjct: 223 YKGYFKC---ECYP 233
Score = 115 bits (289), Expect = 8e-25
Identities = 62/183 (33%), Positives = 89/183 (48%), Gaps = 19/183 (10%)
Query: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDC 3784
F+C+N CIP W+CD +DC D+SDE++C + C +S+F C N CI RW CD +C
Sbjct: 52 FQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEEC 111
Query: 3785 GDNSDERD--CEMRTCHPEYFQC--TSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA 3840
D SDE + C + C E C TS CV + +CDG DC +DEA C T +
Sbjct: 112 PDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNE-- 169
Query: 3841 YCQATMFECKNHVC----------IPPYWKCDGDDDCGDGSD-EELHLCLDVPCNSPNRF 3889
C C +H+C P ++ CGD + ++ C + N F
Sbjct: 170 -CLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 3890 RCD 3892
+C+
Sbjct: 228 KCE 230
Score = 115 bits (287), Expect = 1e-24
Identities = 65/186 (34%), Positives = 93/186 (50%), Gaps = 21/186 (11%)
Query: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
C+ +++QC N+RCIP W+CD +DC D+SDED C +TC F C NG CI + WK
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC-KTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
CD + +C D SDE E + +C + SC T+++C+P C+G DC +DE
Sbjct: 105 CDGEEECPDGSDE--SEATCTKQVCP-AEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
Query: 3713 GCEE--RTC--------HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTES 3762
GC C H D + P +Q Q CGD + ++ P C++
Sbjct: 162 GCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD--PDACSQI 219
Query: 3763 EFRCVN 3768
CVN
Sbjct: 220 ---CVN 222
Score = 114 bits (286), Expect = 2e-24
Identities = 68/200 (34%), Positives = 92/200 (46%), Gaps = 21/200 (10%)
Query: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIP 1081
P + C F C+N RC+P+ + CD DDC D+SDE C TC+ S FTC +G CI
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIH 100
Query: 1082 AHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSD 1139
W+CD +C DGSDE T C + +C +H+C+ +W CD + DC G+D
Sbjct: 101 ERWKCDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1140 EKNCNS-TETCQPSQFNCPNHRCIDL--SFVCDGDKDCVDG---SDEVGCVLNCTASQFK 1193
E C + C + C +H C DL F C C G D+ C +
Sbjct: 160 EAGCATWLNECLHNNGGC-SHICTDLKIGFEC----TCPAGFQLLDQKTC-----GDIDE 209
Query: 1194 CASGDKCIGVTNRCDGVFDC 1213
C D C + G F C
Sbjct: 210 CKDPDACSQICVNYKGYFKC 229
Score = 111 bits (278), Expect = 1e-23
Identities = 66/228 (28%), Positives = 101/228 (44%), Gaps = 46/228 (20%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
Query: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE +
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
Query: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFT---EFSC 3686
CA+ W N+C + +H+C + E +C
Sbjct: 163 CAT-------------------WL----NEC-------LHNNGGCSHICTDLKIGFECTC 192
Query: 3687 KTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIP 3734
++ + + C +D+C+ D C + + G F+C+ C P
Sbjct: 193 PAGFQLLDQ-KTCGDIDECK---DPDACSQICVNYKGYFKCE---CYP 233
Score = 108 bits (269), Expect = 2e-22
Identities = 64/196 (32%), Positives = 92/196 (46%), Gaps = 32/196 (16%)
Query: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE---PIEECMSSAHLCDNFTEFSCKT 3688
++ C QF+C N RCIP W+CD D+DC DHSDE P + C S CD
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--------- 94
Query: 3689 NYRCIPKWAVCNGVDDCRDNSDEQ--GCEERTCHPVGDFRC--KNHHCIPLRWQCDGQND 3744
N CI + C+G ++C D SDE C ++ C P C +H C+P W+CDG+ D
Sbjct: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGEKD 153
Query: 3745 CGDNSDEENCAP--RECTESEFRC--------VNQQC-IPSRWICDHYNDCGDNSDERD- 3792
C +DE CA EC + C + +C P+ + CGD + +D
Sbjct: 154 CEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP 213
Query: 3793 ---CEMRTCHPEYFQC 3805
++ + YF+C
Sbjct: 214 DACSQICVNYKGYFKC 229
Score = 106 bits (264), Expect = 6e-22
Identities = 50/123 (40%), Positives = 73/123 (59%), Gaps = 8/123 (6%)
Query: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI 2877
P + C+ +C N CIP V+ CD D+DC D+SDE+ C TC+ S+F C +G CI
Sbjct: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCI 99
Query: 2878 PQHWYCDQETDCFDASDE-PASCGHSERTCLADEFKC--DGGRCIPSEWICDGDNDCGDM 2934
+ W CD E +C D SDE A+C +++ C A++ C +C+P+ W CDG+ DC
Sbjct: 100 HERWKCDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 2935 SDE 2937
+DE
Sbjct: 158 ADE 160
Score = 94.0 bits (232), Expect = 3e-18
Identities = 60/178 (33%), Positives = 79/178 (44%), Gaps = 20/178 (11%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTC--ANGRCVQYS 2757
C S FTC NG CI E WKCD + +C DGSDE E+ C C +C + +CV S
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
Query: 2758 YRCDYYNDCGDGSDEAGCL--FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS 2812
+RCD DC G+DEAGC +C N +C + + I E C D T
Sbjct: 146 WRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTC 204
Query: 2813 ---DEKNCPDRTCQ-----SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862
DE PD Q GY KC C P + +C + ++P+ T+
Sbjct: 205 GDIDECKDPDACSQICVNYKGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 258
Score = 93.6 bits (231), Expect = 4e-18
Identities = 50/141 (35%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
Query: 2760 CDYYNDCGDGSD--EAGCLFRDCNATTEFMC--NNRRCIPREFICNGVDNCHDNNTSDEK 2815
CD +C DGSD EA C + C A + C + +C+P + C+G +C E
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPA-EKLSCGPTSHKCVPASWRCDGEKDC-------EG 156
Query: 2816 NCPDRTCQSGYTKC-HNSNIC 2835
+ C + +C HN+ C
Sbjct: 157 GADEAGCATWLNECLHNNGGC 177
Score = 90.1 bits (222), Expect = 5e-17
Identities = 61/199 (30%), Positives = 90/199 (45%), Gaps = 31/199 (15%)
Query: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFIC 2800
C F C N RC+ +RCD +DC D SDE C + C A ++F C+N CI + C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTCDNGHCIHERWKC 105
Query: 2801 NGVDNCHDNNTSDEKNCPDRTCQSGYTKCH-NSNICIPRVYLCDGDNDCGDNSDE----- 2854
+G + C D + E C + C + C S+ C+P + CDG+ DC +DE
Sbjct: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Query: 2855 -------NPTYCTTHTCSSSE--FQCASGRCIPQHWYCDQETDCFDASD--EPASCGHSE 2903
N C +H C+ + F+C C DQ+T C D + +P +C
Sbjct: 166 WLNECLHNNGGC-SHICTDLKIGFECT---CPAGFQLLDQKT-CGDIDECKDPDAC---S 217
Query: 2904 RTCL--ADEFKCDGGRCIP 2920
+ C+ FKC+ C P
Sbjct: 218 QICVNYKGYFKCE---CYP 233
Score = 62.0 bits (149), Expect = 1e-08
Identities = 48/176 (27%), Positives = 72/176 (40%), Gaps = 27/176 (15%)
Query: 3493 CPDDFRTLQLSGSTYC-MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCPQ 3550
C +D L S C C+ + F C N CI WKCDG+++C DGSDE A C +
Sbjct: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH-CIHERWKCDGEEECPDGSDESEATCTK 124
Query: 3551 RFCRLGQFQC--SDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCAN----- 3603
+ C + C + C C+ ++C G+DE + C N C++
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDL 184
Query: 3604 ----KRCIPESWQ------CDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIP 3649
+ P +Q C ++C+D D S C + G F+C C P
Sbjct: 185 KIGFECTCPAGFQLLDQKTCGDIDECKD-PDACSQICVN---YKGYFKC---ECYP 233
Score = 33.1 bits (74), Expect = 6.6
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 177 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 232
Query: 4391 FD-ETDL--PKCKCPSG 4404
E DL CK +G
Sbjct: 233 PGYEMDLLTKNCKAAAG 249
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 235 bits (599), Expect = 9e-61
Identities = 181/671 (26%), Positives = 288/671 (42%), Gaps = 101/671 (15%)
Query: 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLD----NSDEKGC-GINECHDPSISGCDHNCTDT 3129
C + C + C + ++ +HL C + + D K C +NEC + GC C +T
Sbjct: 318 CKLRKGNCSSTVCGQDLQ--SHLCMCAEGYALSRDRKYCEDVNECAFWN-HGCTLGCKNT 374
Query: 3130 LTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGK 3189
S+YC+C G+ L+ D + C + C CS C +C C G + E DGK
Sbjct: 375 PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGK 434
Query: 3190 TCR---------------------------------------QNSNIEPYLIFSNRYYLR 3210
TC S +P+L+F+N +R
Sbjct: 435 TCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIR 494
Query: 3211 NLTIDGYFYSLIL-EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRL 3269
++ DG Y +L + + V ALD D VE ++Y+ T + IER ++ + +E +I +
Sbjct: 495 HMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
Query: 3270 PAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALH 3329
E LAVDW+ R+ YW D + SDLNG +++ + + PRG+A+H
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENIS--------QPRGIAVH 606
Query: 3330 PQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYI 3389
P L+W D G I + G + VI S+ L WP+GITID+ D LYW DA I
Sbjct: 607 PMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 3390 EYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTH 3449
E ++L+G R + + HPFA+ +FED ++++DW +V + NK G +R L +
Sbjct: 667 EMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSML 726
Query: 3450 RPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCM 3509
+P + V HP +P ++PC NGGC H+C + G C C + F ++ S C+
Sbjct: 727 KPSSLVVVHPLAKP-GADPCLYQNGGCEHICKKRLGTA--WCSCREGF--MKASDGKTCL 781
Query: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQ 3569
+ DG + + G +L L + + S+ N T Q
Sbjct: 782 AL---------------------DGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQ 820
Query: 3570 TLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
+ A D D + C + +E + A +C+ D + SD D
Sbjct: 821 HMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLK-----GFAGDGKLCSDIDECE 875
Query: 3630 CASRTCRPGQFRCANG------RCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLC-DNFT 3682
C P +C N RC + ++ D G H + I+EC H C +N +
Sbjct: 876 MGVPVCPPASSKCINTEGGYVCRC-SEGYQGD-----GIHCLD-IDECQLGEHSCGENAS 928
Query: 3683 EFSCKTNYRCI 3693
+ + Y C+
Sbjct: 929 CTNTEGGYTCM 939
Score = 205 bits (522), Expect = 7e-52
Identities = 122/396 (30%), Positives = 198/396 (50%), Gaps = 14/396 (3%)
Query: 1352 SCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG-S 1410
SC C+H+CV G C CP G +L D KTC D G CSQ C + S
Sbjct: 400 SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDN-GGCSQLCVPLSPVS 458
Query: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVA 1470
+ C C GY L+ D ++C + + LL SQ+ + + S + + A
Sbjct: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS--QQMGMVYA 516
Query: 1471 VDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYAL 1530
+D D + +I+++ A +G+ R + + + + E +A+DW+GR YWTD
Sbjct: 517 LDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK 576
Query: 1531 ETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRT 1590
I S ++G ++ +N++ PRG+A+ P LFW+D G +PRIE +S+ G R
Sbjct: 577 SLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKR--LFWTDTGINPRIESSSLQGLGRL 634
Query: 1591 VIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTL 1650
VI + WP G+TID+ LY+ D+ ++ + +G RR++ +D + HP+A+ +
Sbjct: 635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAV 692
Query: 1651 FEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR-- 1708
FED V+++D A VMR NK G ++ + ++ P +V VHP +P + +PC +
Sbjct: 693 FEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGG 751
Query: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDD 1744
C H+C G + C C G+ + D CL D
Sbjct: 752 CEHIC-KKRLGTAW--CSCREGFMKASDGKTCLALD 784
Score = 187 bits (476), Expect = 2e-46
Identities = 132/501 (26%), Positives = 223/501 (44%), Gaps = 52/501 (10%)
Query: 217 CNYPTCG----GYQFTCPSGRCIYQNW-VCDGEDDCK--DNGDEDGCESGPHDVHKCSPR 269
C+ CG + C G + ++ C+ ++C ++G GC++ P +
Sbjct: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYY----- 379
Query: 270 EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGA 329
+CP + K C ++ CP E C + C T G
Sbjct: 380 -CTCPVGFVLLPDGKRCHQLVSCPRNVSE------------------CSHDCVLTSEGPL 420
Query: 330 CFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCES-RPGRHLCHCEEGYILERGQY-CKA 387
CFCP G ++ D +TC G C Q C P C C GY L+ + C A
Sbjct: 421 CFCPEGSVLER-DGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA 478
Query: 388 NDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNK 447
+ + ++F+N +D+ G + L+ SQ G+ + ++++ T
Sbjct: 479 SGP--QPFLLFANSQDIRHMHFDGTDYGTLL-SQQMGMVYALDHDPVENKIYFAHTALKW 535
Query: 448 VFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITE 507
+ +++G + ++ V+ PE LAVDW+ + Y + + I +L+G + E
Sbjct: 536 IERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKE 595
Query: 508 NLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMI 567
N+ PRGIAV P LF W P++E + + G R + + L WP+G+T+D +
Sbjct: 596 NISQPRGIAVHPMAKRLF---WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFL 652
Query: 568 SKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKA 627
+ ++YW D++ IE DG +R+ + + HPF V++FE V+F+DW +V++
Sbjct: 653 TDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRV 710
Query: 628 NKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGF 687
NK T + + L+P + V H L +P A +PC NGGCE +C LG
Sbjct: 711 NKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGGCEHIC-------KKRLGT 762
Query: 688 R-CKCTFGFQLDTDERHCIAV 707
C C GF +D + C+A+
Sbjct: 763 AWCSCREGFMKASDGKTCLAL 783
Score = 170 bits (431), Expect = 3e-41
Identities = 112/356 (31%), Positives = 178/356 (50%), Gaps = 16/356 (4%)
Query: 2349 NNGGCSHLCFALPGLHTPKCDCAFG-TLQSDGKNCAIS-TENFLIFALSNSLRSLHLDPE 2406
+NGGCS LC L + +CDC G LQ D K+CA S + FL+FA S +R +H D
Sbjct: 443 DNGGCSQLCVPLSPVSW-ECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
Query: 2407 NHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIG 2466
++ V +LD+D V ++IYF + + + G +I G+
Sbjct: 502 DYGTLLS--QQMGMVYALDHDPVENKIYFAHTALKWIERANM----DGSQRERLIEEGVD 555
Query: 2467 TADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWA 2524
+G+A DWI RR Y++D +I +G +I + + +PR I + P L+W
Sbjct: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
Query: 2525 DWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVD 2584
D + +IE ++L G R+ I +S L+ PSG+T+D+ D LYW DA IE + L G
Sbjct: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
Query: 2585 REVIV-NAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTV 2643
R + N H F + ++ Y++++D + R NK G ++ + ++L +P + V
Sbjct: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSML-KPSSL-VV 733
Query: 2644 VKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGER 2699
V + +PC NGGC HIC A C C EG + A++ K C+ +G +
Sbjct: 734 VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC-REG-FMKASDGKTCLALDGHQ 787
Score = 166 bits (421), Expect = 4e-40
Identities = 131/460 (28%), Positives = 215/460 (46%), Gaps = 68/460 (14%)
Query: 3935 CGNGHCIPHDN-VCDDADDCGDWSDELGCNKGKERT------------------------ 3969
C G+ + D C+D ++C W+ GC G + T
Sbjct: 341 CAEGYALSRDRKYCEDVNECAFWNH--GCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
Query: 3970 --CAENI--CEQNCTQLNEGGFICSCTAGFETNVFDRT--SCLDINECEQFGTCPQHCRN 4023
C N+ C +C +EG +C C G +V +R +C + + G C Q C
Sbjct: 399 VSCPRNVSECSHDCVLTSEGP-LCFCPEG---SVLERDGKTCSGCSSPDN-GGCSQLCVP 453
Query: 4024 TKG-SYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYL-QDE 4081
S+EC C G+ D K CAA G P LL ++ IR + + L Q
Sbjct: 454 LSPVSWECDCFPGYDLQLDE--KSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQM 511
Query: 4082 EYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE-VDLKLKY 4140
+ A+D+D P + + + ++ I+RA + S R L++E VD+
Sbjct: 512 GMVYALDHD--PVENKIYFAHTALKW-------IERANMDG--SQRERLIEEGVDV---- 556
Query: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
P+G+AVDW+GR YW+D I + L+G+ K + ++ QP IAV+P +F
Sbjct: 557 ---PEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
Query: 4201 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD 4260
WTD G P+IES+ + G R ++ DL WP+G++ID+L D++YW D K+ VIE D
Sbjct: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFL-TDKLYWCDAKQSVIEMANLD 672
Query: 4261 GTDRRVIAK-EAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWL--TQ 4317
G+ RR + + + +P+++ +FED +++ V + NK + K++ + L +
Sbjct: 673 GSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNK--RTGKDRVRLQGSMLKPSS 730
Query: 4318 VRIFHQLRYNKSVPNLCKQ-ICSHLCLLRPGGYSCACPQG 4356
+ + H L + P L + C H+C R G C+C +G
Sbjct: 731 LVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG 770
Score = 164 bits (416), Expect = 1e-39
Identities = 107/351 (30%), Positives = 168/351 (47%), Gaps = 16/351 (4%)
Query: 666 NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723
+NGGC Q+CV + + C C G+ L DE+ C A Q FL+F++ IR +
Sbjct: 443 DNGGCSQLCV-----PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
Query: 724 FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRV 783
F + D +S +D D ++ I+F+ + I + +DG+ RE L V
Sbjct: 498 FDGT---DYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
Query: 784 ENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFF 842
+ E LA DWI + YWTD I L K + + + ++ PR + VHP A LF+
Sbjct: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 843 TDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGL 902
TD +I + G L + ++ L WP+G+ ID+ +LYW DA IE + DG
Sbjct: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
Query: 903 DRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKS 962
RRRL + HPF +A+F ++++F+DW + +++RV K G + ++ + L
Sbjct: 675 KRRRLTQ-NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVV 733
Query: 963 YDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC 1013
+ G++ C + NG C H C C C G AS+ TC
Sbjct: 734 VHPLAKPGADPC---LYQNGGCEHICKKRLG-TAWCSCREGFMKASDGKTC 780
Score = 139 bits (350), Expect = 7e-32
Identities = 178/786 (22%), Positives = 310/786 (39%), Gaps = 173/786 (22%)
Query: 1414 SCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDF 1473
SC G + + TC A L+ + N I + ++ N LV + V +DF
Sbjct: 27 SCPEGTLAGNGNSTCVGPAP---FLIFSHGNSIFR--IDTEGTNYEQLVVDAGVSVIMDF 81
Query: 1474 DSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETI 1533
RI+W D + F NG+ + V + ++ +AI+W+ + W++ I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG-MAINWINEEVIWSNQQEGII 140
Query: 1534 EVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIV 1593
V+ + G++ +L+S L P +A+DP E +FWS + RA +DG ++
Sbjct: 141 TVTDMKGNNSHILLSA-LKYPANVAVDP--VERFIFWSS-EVAGSLYRADLDGVGVKALL 196
Query: 1594 Q--DKIFWPCGLTIDYPNRLLYFM----DSYLDYMDFCDYNGHHRRQVIASDLIIRHP-- 1645
+ +KI +++D ++ L+++ + + CDY+G S I +HP
Sbjct: 197 ETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-------GSVHISKHPTQ 246
Query: 1646 ---YALTLFEDSVYWTDRATRRVMRANKWHGGNQ-SVVMYNIQWPLG-IVAVHPSKQPNS 1700
+A++LF D ++++ + + ANK G + + +++ PLG + VHP QP +
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
Query: 1701 --------------------------------------------------VNPCAFSRCS 1710
VN CAF +
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAF--WN 364
Query: 1711 HLCLLSSQG-PHFYSCVCPSGWSLSPD------LLNCLRD----DQPFLITVRQHIIF-- 1757
H C L + P Y C CP G+ L PD L++C R+ ++T + F
Sbjct: 365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424
Query: 1758 -------------GISLNPEVKSNDAMVPIAGIQ------NGLDVEFDD------AEQYI 1792
G S + VP++ + G D++ D+ Q
Sbjct: 425 EGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPF 484
Query: 1793 YWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHG 1852
N +I + DGT+ S M G L D + +Y + + IE + G
Sbjct: 485 LLFANSQDIRHMHFDGTDYGTLLSQQM-GMVYALDHDPVENKIYFAHTALKWIERANMDG 543
Query: 1853 DIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQG--------------------- 1891
R R LI GV P G+ VD + YW+D+G
Sbjct: 544 SQRER--LIEE-----GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKEN 596
Query: 1892 ------------------TDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKL 1933
TD+G+ +I S+++ G + + +L +T+D KL
Sbjct: 597 ISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKL 656
Query: 1934 YWAVTGRGVIERGNVDGTDRMILV-HQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGA 1992
YW + VIE N+DG+ R L + + HP+ +AV + +++++D + RV+K TG
Sbjct: 657 YWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGK 716
Query: 1993 NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLN 2052
+++ L+ ++ L V H A ++ C C+ IC G + C+C GF
Sbjct: 717 DRVRLQGSMLKPSSLVVVHPL-AKPGADPCLYQNGGCEHICKKRLGTAW-CSCREGFMKA 774
Query: 2053 PDNRSC 2058
D ++C
Sbjct: 775 SDGKTC 780
Score = 130 bits (328), Expect = 2e-29
Identities = 96/370 (25%), Positives = 160/370 (43%), Gaps = 27/370 (7%)
Query: 2017 ESSNGCSNNMNA-CQQICLPVPGGLFSCACATGFKLNPDNRSC--SPYNSFIVVSMLSAI 2073
++ +GCS+ N C Q+C+P+ + C C G+ L D +SC S F++ + I
Sbjct: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDI 493
Query: 2074 RGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSS 2133
R + +D+ + G +D D IY+ + I R DGS
Sbjct: 494 RHMHFDGTDYGTLLSQQMGM---VYALDHDPVENKIYFAH-----TALKWIERANMDGSQ 545
Query: 2134 LMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPR 2193
++ G+ + G+AVDW+ Y+T+ ++LI +N +++ K + PR
Sbjct: 546 RERLIEEGV--DVPEGLAVDWIGRRFYWTDR--GKSLIGRSDLNGKRSKIITKENISQPR 601
Query: 2194 HIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDD 2253
I V P + LFW D G P+IE S L R V+ S ++ P G+ +D +YW D
Sbjct: 602 GIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDA 661
Query: 2254 SLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPP 2313
+I ++G + P+ + VFE+ + + D + + + +K
Sbjct: 662 KQSVIEMANLDGSKRRRLTQND-VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTG----- 715
Query: 2314 TVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFG 2373
+D + + V A+ +PCL NGGC H+C L T C C G
Sbjct: 716 ---KDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHIC--KKRLGTAWCSCREG 770
Query: 2374 TLQ-SDGKNC 2382
++ SDGK C
Sbjct: 771 FMKASDGKTC 780
Score = 117 bits (293), Expect = 3e-25
Identities = 119/499 (23%), Positives = 208/499 (41%), Gaps = 65/499 (13%)
Query: 3173 SYICKCAPGYLREPDGKTCRQNSNIE-----PYLIFSNRYYLRNLTIDGYFYSLILEGLD 3227
S++ AP + P+G T N N P+LIFS+ + + +G Y ++
Sbjct: 16 SFVSLSAPQHWSCPEG-TLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAG 74
Query: 3228 NVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWL 3287
V +DF EKR+YW+D +RQ+++R+FLN + +E + N +A++W++ ++ W
Sbjct: 75 VSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWS 133
Query: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347
+ + + V+D+ G + +L P +A+ P +++W+ +
Sbjct: 134 NQQEGIITVTDMKGNNSHILLS---------ALKYPANVAVDPVERFIFWSS-EVAGSLY 183
Query: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYW----ADAHLGYIEYSDLEGHHRHTVY 3403
R +DG ++ T E +++D + L+W + I D +G H
Sbjct: 184 RADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISK 242
Query: 3404 DGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPF----DIHVYHP 3459
+ FA+++F D I+++ W +T+ NK+ G + + H F ++ V HP
Sbjct: 243 HPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRI--NLHSSFVPLGELKVVHP 300
Query: 3460 YRQPIVSNP--------CGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPM 3511
QP + C G CS + + C C + + + YC +
Sbjct: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYALSR--DRKYCEDV 357
Query: 3512 --CSSTQFLCANNEKCIPIWWKCD---GQKDCSDGS--DELALCPQRFCRLGQFQCS-DG 3563
C+ C K P + C G DG +L CP+ +CS D
Sbjct: 358 NECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVS-----ECSHDC 412
Query: 3564 NCTSPQTLCNAHQNCPDGS--DEDRLLCENHHCDSNEWQCANKRCI---PESWQCDTFND 3618
TS LC CP+GS + D C C S + ++ C+ P SW+CD F
Sbjct: 413 VLTSEGPLC----FCPEGSVLERDGKTCSG--CSSPDNGGCSQLCVPLSPVSWECDCFPG 466
Query: 3619 CEDNSDEDSSHCASRTCRP 3637
+ DE S CA+ +P
Sbjct: 467 YDLQLDEKS--CAASGPQP 483
Score = 109 bits (273), Expect = 6e-23
Identities = 98/353 (27%), Positives = 164/353 (46%), Gaps = 47/353 (13%)
Query: 373 CEEGYILERGQY-CKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAF 431
C EG + G C F +IFS+G + D G ++ LV + GV+V + F
Sbjct: 28 CPEGTLAGNGNSTCVGPAPF----LIFSHGNSIFRIDTEGTNYEQLVV--DAGVSVIMDF 81
Query: 432 HYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRI 491
HY+ +R++W D + + V +NG + V N+ + +A++W+N ++ + I
Sbjct: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGII 140
Query: 492 DMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDL 551
+ ++ G+ L++ L +P +AVDP ++F+S ++G L RA +DG K L
Sbjct: 141 TVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWS--SEVAG--SLYRADLDGVGVKAL 195
Query: 552 VKTKLGWPAGVTLDMISKRVYWV----DSRFDYIETVTYDGIQRKTVVHGGSLIPHP--- 604
++T A V+LD++ KR++W+ + I + YDG VH + HP
Sbjct: 196 LETSEKITA-VSLDVLDKRLFWIQYNREGSNSLICSCDYDG----GSVH---ISKHPTQH 247
Query: 605 --FGVSLFEGQVFFTDWTKMAVLKANKFT-ETNPQVYYQASLRPYG-VTVYHSLRQPYAT 660
F +SLF ++F++ W + ANK T + ++ +S P G + V H L QP A
Sbjct: 248 NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAE 307
Query: 661 NP--------CKDNNGGCEQ-VCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
+ CK G C VC D C C G+ L D ++C
Sbjct: 308 DDTWEPEQKLCKLRKGNCSSTVC------GQDLQSHLCMCAEGYALSRDRKYC 354
Score = 74.3 bits (181), Expect = 3e-12
Identities = 77/376 (20%), Positives = 150/376 (39%), Gaps = 44/376 (11%)
Query: 691 CTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDA 750
C G C+ FLIFS +I I + E ++V + V +DF
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVS----VIMDFHY 83
Query: 751 QDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISV 810
+ I++ D+ + ++ + ++G+ +E + N +NV +A +WI++ + W++ I+V
Sbjct: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIITV 142
Query: 811 MRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870
+ ++ L P +V V P ++F++ + RA DG + ++ T+
Sbjct: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEV-AGSLYRADLDGVGVKALLETS-E 200
Query: 871 WPNGLAIDWAASRLYWV----DAYFDKIEHSTFDGLDRRRLGHIEQMTHP-----FGLAI 921
+++D RL+W+ + I +DG G + HP F +++
Sbjct: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG------GSVHISKHPTQHNLFAMSL 254
Query: 922 FGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYI-----------LHLKSYDVNIQTG 970
FG+ +F++ W++ I K G +M I +++ K+ D +
Sbjct: 255 FGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
Query: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFS 1030
C G+CS +C C G L+ + CE +C ++
Sbjct: 315 QKLCKL---RKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCE-------DVNECAFWN 364
Query: 1031 FPCKNG-RCVPNYYLC 1045
C G + P Y C
Sbjct: 365 HGCTLGCKNTPGSYYC 380
Score = 66.2 bits (160), Expect = 7e-10
Identities = 99/476 (20%), Positives = 175/476 (36%), Gaps = 72/476 (15%)
Query: 2358 FALPGLHTPK-CDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTIN 2416
F+ L P+ C GTL +G + + FLIF+ NS+ + + N+ Q +
Sbjct: 15 FSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYE---QLVV 71
Query: 2417 VERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWI 2476
+ +D+ RIY+ Q+ +G V + G+A +WI
Sbjct: 72 DAGVSVIMDFHYNEKRIYWVDL----ERQLLQRVFLNGSRQERV-CNIEKNVSGMAINWI 126
Query: 2477 TRRIYYSDYLNQMINSMAEDGSNRTVIARVPK-PRAIVLDPCQGYLYWADWDTHAKIERA 2535
+ +S+ +I G+N ++ K P + +DP + +++W+ + + RA
Sbjct: 127 NEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSS-EVAGSLYRA 185
Query: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWV----DASLQRIERSTLTGVDREVIVNA 2591
L G ++ +S + + ++LD + L+W+ + S I G + +
Sbjct: 186 DLDGVGVKALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHP 244
Query: 2592 AVH-AFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQ 2650
H F ++L+G I+++ + I+ ANK+ G + + + P G VV Q
Sbjct: 245 TQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQP 304
Query: 2651 C---------NNPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC 2700
C+ G CS +C C C + L+ +RK+C ++ C
Sbjct: 305 KAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAE--GYALSRDRKYC--EDVNEC 360
Query: 2701 ---------------GASSFTCSNGRCISEEWK-CDNDNDCGDGSDEMESVCALHTCSPT 2744
G+ TC G + + K C C E C L + P
Sbjct: 361 AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL 420
Query: 2745 AF------------TCA------NGRCVQ-------YSYRCDYYNDCGDGSDEAGC 2775
F TC+ NG C Q S+ CD + DE C
Sbjct: 421 CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
Score = 57.0 bits (136), Expect = 4e-07
Identities = 73/329 (22%), Positives = 128/329 (38%), Gaps = 76/329 (23%)
Query: 4146 GIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG 4205
G+A++W+ + WS+ + I V + G L+S L PA +AV+P +FW+
Sbjct: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-E 177
Query: 4206 KEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED----VIETIKYDG 4261
+ A ++G L+ E T +S+D L+ R++W + + +I + YDG
Sbjct: 178 VAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDK-RLFWIQYNREGSNSLICSCDYDG 235
Query: 4262 TDRRVIAKEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPW---LTQ 4317
+ N +++ +F D++++ + + +W NK GK + ++ L +
Sbjct: 236 GSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGE 294
Query: 4318 VRIFHQLRYNKSVPN-------LCK--------QIC-----SHLCLL------------- 4344
+++ H L K+ + LCK +C SHLC+
Sbjct: 295 LKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Query: 4345 -------------------RPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMH 4385
PG Y C CP G + C + P N+ C H
Sbjct: 355 EDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDG-KRCHQLVSCPRNV---SECSH 410
Query: 4386 GGNCYFDETDLPKCKCPSGYT----GKYC 4410
+C ++ P C CP G GK C
Sbjct: 411 --DCVL-TSEGPLCFCPEGSVLERDGKTC 436
Score = 54.3 bits (129), Expect = 3e-06
Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 37/352 (10%)
Query: 2044 ACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVD 2103
+C G N +C F++ S ++I E +++ + +V ++ +D
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV----SVIMDFH 82
Query: 2104 VSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTN 2163
+ IYW D + ++R+ +GS + E V G+A++W+ + ++N
Sbjct: 83 YNEKRIYWVDLERQL-----LQRVFLNGSRQERVCNI---EKNVSGMAINWINEEVIWSN 134
Query: 2164 AFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCT 2223
E +I V + +LL + P ++ VDP R++FW+ + R+ LD
Sbjct: 135 Q--QEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGV 190
Query: 2224 NRTVLV--SEGIVTPRGLAVDRSDGYVYWV----DDSLDIIARIRINGENSEVIRYGSRY 2277
L+ SE I +++D D ++W+ + S +I +G + + S++
Sbjct: 191 GVKALLETSEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI----SKH 243
Query: 2278 PTP---YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQ 2334
PT + +++F + I + +K I+ A+K + + L ++ + Q
Sbjct: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
Query: 2335 PRSPA---EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFG-TLQSDGKNC 2382
P++ E C G CS L + C CA G L D K C
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCG-QDLQSHLCMCAEGYALSRDRKYC 354
Score = 53.1 bits (126), Expect = 6e-06
Identities = 44/135 (32%), Positives = 58/135 (42%), Gaps = 26/135 (19%)
Query: 3092 KLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV 3151
KLC+ +D+C E P C +T + C C GY+ D C+
Sbjct: 866 KLCSDIDEC------------EMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCL 911
Query: 3152 DIDECTEMPFVCSQK--CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY- 3208
DIDEC C + C N G Y C CA G L EP G C +S P+L + +Y
Sbjct: 912 DIDECQLGEHSCGENASCTNTEGGYTCMCA-GRLSEP-GLIC-PDSTPPPHLREDDHHYS 968
Query: 3209 LRN------LTIDGY 3217
+RN L+ DGY
Sbjct: 969 VRNSDSECPLSHDGY 983
Score = 50.8 bits (120), Expect = 3e-05
Identities = 29/76 (38%), Positives = 35/76 (46%), Gaps = 10/76 (13%)
Query: 1359 GCTH--ECVQEPFGAKCLCPLGFLLANDSKTCEDIDECD----ILGSCSQHCYNMRGSFR 1412
GC+ C+ E A C C GF A D K C DIDEC+ + S C N G +
Sbjct: 839 GCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYV 896
Query: 1413 CSCDTGYMLESDGRTC 1428
C C GY + DG C
Sbjct: 897 CRCSEGY--QGDGIHC 910
Score = 49.3 bits (116), Expect = 9e-05
Identities = 30/82 (36%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 3984 EGGFICSCTAGFETNVFDRTSCLDINECEQFG--TCPQH--CRNTKGSYECVCADGFTSM 4039
EGG++C C+ G++ D CLDI+EC Q G +C ++ C NT+G Y C+CA +
Sbjct: 892 EGGYVCRCSEGYQG---DGIHCLDIDEC-QLGEHSCGENASCTNTEGGYTCMCAGRLS-- 945
Query: 4040 SDRPGKRCAAEGSSPLLLLPDN 4061
PG C P L D+
Sbjct: 946 --EPGLICPDSTPPPHLREDDH 965
Score = 42.7 bits (99), Expect = 0.008
Identities = 39/152 (25%), Positives = 57/152 (37%), Gaps = 41/152 (26%)
Query: 4342 CLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP-----------------CR-- 4382
C GGY+C C S + + P + PPP C
Sbjct: 929 CTNTEGGYTCMCAGRLS---------EPGLICPDSTPPPHLREDDHHYSVRNSDSECPLS 979
Query: 4383 ----CMHGGNC-YFDETDLPKCKCPSGYTGKYCEMAFSK-------GISPGTTAVAVLLT 4430
C+H G C Y + D C C GY G+ C+ K G + V +
Sbjct: 980 HDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVC 1039
Query: 4431 ILLIVVIGALAIAGFFHYRRTGSLLPALPKLP 4462
++++V++ L++ G HY RT LL PK P
Sbjct: 1040 VVVLVMLLLLSLWG-AHYYRTQKLLSKNPKNP 1070
Score = 42.0 bits (97), Expect = 0.014
Identities = 26/72 (36%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 3970 CAENICEQNCTQLNEG-GFICSCTAGFETNVFDRTSCLDINECEQ-FGTCP---QHCRNT 4024
CA C ++EG C C GF D C DI+ECE CP C NT
Sbjct: 835 CAPVGCSMYARCISEGEDATCQCLKGFAG---DGKLCSDIDECEMGVPVCPPASSKCINT 891
Query: 4025 KGSYECVCADGF 4036
+G Y C C++G+
Sbjct: 892 EGGYVCRCSEGY 903
Score = 39.3 bits (90), Expect = 0.092
Identities = 19/45 (42%), Positives = 24/45 (53%)
Query: 1353 CSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDIL 1397
C NGGC H C + A C C GF+ A+D KTC +D +L
Sbjct: 745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLL 789
Score = 38.9 bits (89), Expect = 0.12
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 13/72 (18%)
Query: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLL-------------LLVASQN 1444
G C C G+ CSC G+M SDG+TC LL L + S+
Sbjct: 750 GGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKT 809
Query: 1445 KIIADSVTSQVH 1456
++ D++T H
Sbjct: 810 RVSEDNITESQH 821
Score = 36.2 bits (82), Expect = 0.78
Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 9/72 (12%)
Query: 312 CSALNCQY--QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW-GIC---DQKCESR 365
C+ + C +C C C G+ D + C + D+C++ +C KC +
Sbjct: 835 CAPVGCSMYARCISEGEDATCQCLKGFA---GDGKLCSDIDECEMGVPVCPPASSKCINT 891
Query: 366 PGRHLCHCEEGY 377
G ++C C EGY
Sbjct: 892 EGGYVCRCSEGY 903
Score = 34.3 bits (77), Expect = 3.0
Identities = 58/247 (23%), Positives = 83/247 (33%), Gaps = 63/247 (25%)
Query: 2974 GDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC-LYQTC 3032
G+VD + ++ SE+ T + + +I D+ +DC GC +Y C
Sbjct: 792 GEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQ-DDCAPV----GCSMYARC 846
Query: 3033 --QQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNG----- 3085
+ TCQ C+ K F D C D + C P CPP KC N
Sbjct: 847 ISEGEDATCQ---CL-KGFAGD-GKLCSDIDE-----CEMGVPVCPPASSKCINTEGGYV 896
Query: 3086 -RCIEMMK----LCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCR-- 3138
RC E + C +D+C E CG N +CT+T + C C
Sbjct: 897 CRCSEGYQGDGIHCLDIDEC--QLGEHSCGENA-----------SCTNTEGGYTCMCAGR 943
Query: 3139 ------------PGYKLMSDKRTCVDIDECTEMPFVCSQKCEN--------VIGSYICKC 3178
P L D + +E P C + + Y C C
Sbjct: 944 LSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNC 1003
Query: 3179 APGYLRE 3185
GY+ E
Sbjct: 1004 VVGYIGE 1010
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 199 bits (507), Expect = 4e-50
Identities = 122/381 (32%), Positives = 157/381 (41%), Gaps = 73/381 (19%)
Query: 35 CGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCD 94
CG+ C W C G D V C +G CQ G C+P+ W+CD DC
Sbjct: 1350 CGNCTCQEGQWHCGG------DGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCG 1403
Query: 95 DGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQ--LTC 152
DGSDE + C+ C Q+TCS+G C+P CD DC DG DE YP C Q L C
Sbjct: 1404 DGSDE-EGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP--SYP-CPQGLLAC 1459
Query: 153 DNGACYNTSQKCDWKVDCRDSSDEINC--TEICLHNEFSCGNGECIPRAYVCDHDNDCQD 210
+G C + CD DC D++DE +C C+ E SC +G C+ +CD DC D
Sbjct: 1460 ADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPD 1519
Query: 211 GSDE----------------------------------HACNYPTCGGYQFTCPSGRCIY 236
G+DE A P CG ++F C SG C
Sbjct: 1520 GADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTP 1579
Query: 237 QNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE 296
+ W CD E+DC D DE GC GP C+P C C+S ++CDG+ CP
Sbjct: 1580 RGWRCDQEEDCADGSDERGC-GGP-----CAPHHAPCARGPHCVSPEQLCDGVRQCPDGS 1633
Query: 297 DENNTS------------TGKYCSMTLCSALNC---QYQCHETPYGGACFCPPGYIINHN 341
DE + TG C C C Q C P G PG +
Sbjct: 1634 DEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGR----PGQVGPSP 1689
Query: 342 DSRTCVEFDDCQIWGICDQKC 362
+ + C + WG C + C
Sbjct: 1690 EEQGCGAWGPWSPWGPCSRTC 1710
Score = 187 bits (474), Expect = 3e-46
Identities = 140/476 (29%), Positives = 180/476 (37%), Gaps = 84/476 (17%)
Query: 3532 CDGQKDCSDGSDELALCPQRFCRLG-------QFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
CD DC +A R G Q CS C Q CP
Sbjct: 1236 CDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSL-QCEGGQVYEACGPTCPP---- 1290
Query: 3585 DRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCR----PG-- 3638
C H + W C C+ E C + + + C R PG
Sbjct: 1291 ---TCHEQHPEPG-WHCQVVACV-EGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSV 1345
Query: 3639 -QFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWA 3697
Q C N C W C D G H +E + C LC N C+P
Sbjct: 1346 LQKDCGNCTCQEGQWHCGGD---GGHCEELVPACAEGEALCQE--------NGHCVPHGW 1394
Query: 3698 VCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPR 3757
+C+ DDC D SDE+GC C G C + HC+PL CD Q+DCGD +DE +
Sbjct: 1395 LCDNQDDCGDGSDEEGCAAPGCGE-GQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYP-- 1451
Query: 3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMR-TCHPEYFQCTSGHCVHSELK 3816
C + C + +C+P +CD + DC D +DE C + TC P C G C+ +
Sbjct: 1452 -CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQL 1510
Query: 3817 CDGSADCLDASDEAD--CP---------------------------TRFPDGAYCQATMF 3847
CDG DC D +DE CP C F
Sbjct: 1511 CDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEF 1570
Query: 3848 ECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNN-RCIYSHEVCNGV 3906
C + C P W+CD ++DC DGSDE PC +P+ C C+ ++C+GV
Sbjct: 1571 RCGSGECTPRGWRCDQEEDCADGSDER---GCGGPC-APHHAPCARGPHCVSPEQLCDGV 1626
Query: 3907 DDCGDGTDETEEHCR--------KPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCG 3954
C DG+DE + C T PC EY C NG CI VCD DCG
Sbjct: 1627 RQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYT--CPNGTCIGFQLVCDGQPDCG 1680
Score = 179 bits (455), Expect = 4e-44
Identities = 120/375 (32%), Positives = 155/375 (41%), Gaps = 81/375 (21%)
Query: 2788 CNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT--CQSGYTKCHNSNICIPRVYLCDGD 2845
C N C ++ C G D +C + C G C + C+P +LCD
Sbjct: 1350 CGNCTCQEGQWHCGG----------DGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQ 1399
Query: 2846 NDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERT 2905
+DCGD SDE C C + C+SG C+P CD++ DC D +DEP+
Sbjct: 1400 DDCGDGSDEEG--CAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSY------P 1451
Query: 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQ-NCSDSEFLCVNDRPPDRR 2964
C C GRC+P +CDG DC D +DE+ C Q C E CV D
Sbjct: 1452 CPQGLLACADGRCLPPALLCDGHPDCLDAADEES---CLGQVTCVPGEVSCV-----DGT 1503
Query: 2965 CIPQSWVCDGDVDCTDGYDENQ-NCTRRT------------------------------- 2992
C+ +CDG DC DG DE +C +
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563
Query: 2993 -CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNG-RCISKTFV 3050
C EF CG G C P+ +RCD+ DC D SDERGC C + C G C+S +
Sbjct: 1564 PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPCARGPHCVSPEQL 1622
Query: 3051 CDEDNDCGDGSDELMHLCHT------PEPT---CPPHEFKCDNGRCIEMMKLCNHLDDC- 3100
CD C DGSDE C P T CP E+ C NG CI +C+ DC
Sbjct: 1623 CDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCP--EYTCPNGTCIGFQLVCDGQPDCG 1680
Query: 3101 -----LDNSDEKGCG 3110
+ +E+GCG
Sbjct: 1681 RPGQVGPSPEEQGCG 1695
Score = 171 bits (432), Expect = 2e-41
Identities = 132/465 (28%), Positives = 176/465 (37%), Gaps = 111/465 (23%)
Query: 19 CLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEG 78
C AP C C SGHC+P CD DC D DE C QG C ++G
Sbjct: 1411 CAAPG----CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS---YPCPQGLLAC-ADG 1462
Query: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGAD 138
+C+P + +CD DC D +DE Q TC +++C +G C+ + CD V DCPDGAD
Sbjct: 1463 RCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGAD 1522
Query: 139 E--NDCQYPTCE----------------------------------QLTCDNGACYNTSQ 162
E C P+ + C +G C
Sbjct: 1523 EGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGW 1582
Query: 163 KCDWKVDCRDSSDEINCTEICLHNEFSCGNG-ECIPRAYVCDHDNDCQDGSDE--HAC-N 218
+CD + DC D SDE C C + C G C+ +CD C DGSDE AC
Sbjct: 1583 RCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642
Query: 219 YPTCGG--------YQFTCPSGRCIYQNWVCDGEDDCKDNG------DEDGCES-GPHD- 262
P GG ++TCP+G CI VCDG+ DC G +E GC + GP
Sbjct: 1643 LPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSP 1702
Query: 263 ----VHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNT---------------ST 303
C P W S RC + + + +CPG E ++ S
Sbjct: 1703 WGPCSRTCGP--WGQGRSRRCSPLGLLV--LQNCPGPEHQSQACFTAACPVDGEWSTWSP 1758
Query: 304 GKYCSMTLCSALNCQYQCHETPYGG-ACFCPPGYIINHNDSRTCVEFDDC---------- 352
CS + Q QCH GG C PG + + ++ C + D C
Sbjct: 1759 WSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQ-DGCPNATCSGELM 1817
Query: 353 -QIWGICDQKCESRPGRHL-----------CHCEEGYILERGQYC 385
Q C C+ G+ C C EG +L +C
Sbjct: 1818 FQPCAPCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWC 1862
Score = 168 bits (425), Expect = 1e-40
Identities = 116/385 (30%), Positives = 159/385 (41%), Gaps = 40/385 (10%)
Query: 1034 KNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCV 1093
+NG CVP+ +LCD DDC D SDE+ C C TC G C+P CD+++DC
Sbjct: 1385 ENGHCVPHGWLCDNQDDCGDGSDEEGCAAPG--CGEGQMTCSSGHCLPLALLCDRQDDCG 1442
Query: 1094 DGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ 1153
DG+DE + P C C + +C+ +CD DC D +DE++C TC P +
Sbjct: 1443 DGTDEPSYP------CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGE 1496
Query: 1154 FNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDC 1213
+C + C+ +CDG DC DG+DE +C G + G D
Sbjct: 1497 VSCVDGTCLGAIQLCDGVWDCPDGADEGPG--HCPLPSLPTPPASTLPGPS---PGSLDT 1551
Query: 1214 SDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPS 1273
+ + + P P C EF+C G C P W CD DC GSDE P C
Sbjct: 1552 ASSPLASASPAPP---CGPFEFRC-GSGECTPRGWRCDQEEDCADGSDERGCGGP--CAP 1605
Query: 1274 SYFHCDNG-NCIHRAWLCDRDNDCGDMSDE--KDCPTQP---------FRCPSWQWQCLG 1321
+ C G +C+ LCD C D SDE C P CP ++ C
Sbjct: 1606 HHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCP--EYTC-P 1662
Query: 1322 HNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFN-----GGCTHECVQEPFGAKCLC- 1375
+ C+ +VCDG DC P C + G C+ C G C
Sbjct: 1663 NGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCS 1722
Query: 1376 PLGFLLANDSKTCEDIDECDILGSC 1400
PLG L+ + E + +C
Sbjct: 1723 PLGLLVLQNCPGPEHQSQACFTAAC 1747
Score = 166 bits (419), Expect = 7e-40
Identities = 118/400 (29%), Positives = 156/400 (39%), Gaps = 72/400 (18%)
Query: 3606 CIPESWQCDTFNDCE----------DNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCD 3655
C+ ++ CD+ DCE D H R+ +C G+ + +A
Sbjct: 1229 CLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQ-VYEACGPT 1287
Query: 3656 VDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE 3715
C + EP C A C C P+ + +G C + +
Sbjct: 1288 CPPTCHEQHPEPGWHCQVVA----------CVEGCFC-PEGTLLHG-GACLEPASCPCEW 1335
Query: 3716 ERTCHPVGDFR---CKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQC 3771
R P G C N C +W C G D E P C E E C N C
Sbjct: 1336 GRNSFPPGSVLQKDCGNCTCQEGQWHCGG-----DGGHCEELVPA-CAEGEALCQENGHC 1389
Query: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEAD 3831
+P W+CD+ +DCGD SDE C C C+SGHC+ L CD DC D +DE
Sbjct: 1390 VPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS 1449
Query: 3832 CPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRC 3891
P C + C + C+PP CDG DC D +DEE CL P C
Sbjct: 1450 YP--------CPQGLLACADGRCLPPALLCDGHPDCLDAADEES--CLGQVTCVPGEVSC 1499
Query: 3892 DNNRCIYSHEVCNGVDDCGDGTDETEEHC---RKPTPK---------------------- 3926
+ C+ + ++C+GV DC DG DE HC PTP
Sbjct: 1500 VDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASA 1559
Query: 3927 ----PCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
PC +E++CG+G C P CD +DC D SDE GC
Sbjct: 1560 SPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC 1599
Score = 163 bits (412), Expect = 4e-39
Identities = 125/424 (29%), Positives = 167/424 (39%), Gaps = 76/424 (17%)
Query: 982 GDCSHFCFPVPNFQRVCGCP-YGMRLASNHLT---CEGDPTNE------PPT--EQCGLF 1029
GDC C + + C + +R S L CEG E PPT EQ
Sbjct: 1240 GDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACGPTCPPTCHEQHPEP 1299
Query: 1030 SFPCKNGRCVPNYYLCDGV----DDCHDNSDEQLCGTLNNTCSSSAFT--CGHGECIPAH 1083
+ C+ CV + +G C + + N+ S CG+ C
Sbjct: 1300 GWHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQ 1359
Query: 1084 WRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC-DNHQCISKNWVCDTDNDCGDGSDEKN 1142
W C G D +C PA C + + C +N C+ W+CD +DCGDGSDE+
Sbjct: 1360 WHC--------GGDGGHCEELVPA-CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEG 1410
Query: 1143 CNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIG 1202
C + C Q C + C+ L+ +CD DC DG+DE C CA G +C+
Sbjct: 1411 C-AAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS--YPCPQGLLACADG-RCLP 1466
Query: 1203 VTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDE 1262
CDG DC D +DE C + C E C DG C+ CDG DC G+DE
Sbjct: 1467 PALLCDGHPDCLDAADEESCLGQV--TCVPGEVSC-VDGTCLGAIQLCDGVWDCPDGADE 1523
Query: 1263 ---------------------------------HNACVPKTCPSSYFHCDNGNCIHRAWL 1289
+A C F C +G C R W
Sbjct: 1524 GPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWR 1583
Query: 1290 CDRDNDCGDMSDEKDC--PTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESP- 1346
CD++ DC D SDE+ C P P P C CV+ +CDG+ CP+G+DE P
Sbjct: 1584 CDQEEDCADGSDERGCGGPCAPHHAP-----CARGPHCVSPEQLCDGVRQCPDGSDEGPD 1638
Query: 1347 LCNG 1350
C G
Sbjct: 1639 ACGG 1642
Score = 162 bits (409), Expect = 9e-39
Identities = 105/322 (32%), Positives = 135/322 (41%), Gaps = 59/322 (18%)
Query: 3509 MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSP 3568
+P C+ + LC N C+P W CD Q DC DGSDE C C GQ CS G+C
Sbjct: 1373 VPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEG-CAAPGCGEGQMTCSSGHCLPL 1431
Query: 3569 QTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSS 3628
LC+ +C DG+DE ++ C CA+ RC+P + CD DC D +DE+S
Sbjct: 1432 ALLCDRQDDCGDGTDE-----PSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEES- 1485
Query: 3629 HCASR-TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEEC---------------- 3671
C + TC PG+ C +G C+ CD DC D +DE C
Sbjct: 1486 -CLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGP 1544
Query: 3672 --------------MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEER 3717
S A C F EF C + C P+ C+ +DC D SDE+GC
Sbjct: 1545 SPGSLDTASSPLASASPAPPCGPF-EFRCGSG-ECTPRGWRCDQEEDCADGSDERGC-GG 1601
Query: 3718 TCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTE--------------SE 3763
C P + HC+ CDG C D SDE P C E
Sbjct: 1602 PCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDE---GPDACGGLPALGGPNRTGLPCPE 1658
Query: 3764 FRCVNQQCIPSRWICDHYNDCG 3785
+ C N CI + +CD DCG
Sbjct: 1659 YTCPNGTCIGFQLVCDGQPDCG 1680
Score = 148 bits (373), Expect = 1e-34
Identities = 104/344 (30%), Positives = 134/344 (38%), Gaps = 86/344 (25%)
Query: 2707 CSNGRCISEEWK----------------------------------CDNDNDCGDGSDEM 2732
C N C +W CDN +DCGDGSD
Sbjct: 1350 CGNCTCQEGQWHCGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSD-- 1407
Query: 2733 ESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRR 2792
E CA C TC++G C+ + CD +DCGDG+DE C C + R
Sbjct: 1408 EEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS---YPCPQGL-LACADGR 1463
Query: 2793 CIPREFICNGVDNCHDNNTSDEKNCPDR-TCQSGYTKCHNSNICIPRVYLCDGDNDCGDN 2851
C+P +C+G +C D +DE++C + TC G C + C+ + LCDG DC D
Sbjct: 1464 CLPPALLCDGHPDCLD--AADEESCLGQVTCVPGEVSCVDGT-CLGAIQLCDGVWDCPDG 1520
Query: 2852 SDENPTYCTTHT--------------------------------CSSSEFQCASGRCIPQ 2879
+DE P +C + C EF+C SG C P+
Sbjct: 1521 ADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPR 1580
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKC-DGGRCIPSEWICDGDNDCGDMSDED 2938
W CDQE DC D SDE CG C C G C+ E +CDG C D SDE
Sbjct: 1581 GWRCDQEEDCADGSDE-RGCG---GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEG 1636
Query: 2939 KRHQCQNQNC----SDSEFLCVNDRPPDRRCIPQSWVCDGDVDC 2978
C + + C P+ CI VCDG DC
Sbjct: 1637 P-DACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 144 bits (363), Expect = 2e-33
Identities = 101/335 (30%), Positives = 135/335 (40%), Gaps = 78/335 (23%)
Query: 2814 EKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA- 2872
+K+C + TCQ G + C GD G + +E C+ E C
Sbjct: 1347 QKDCGNCTCQEGQ-------------WHCGGD---GGHCEE-----LVPACAEGEALCQE 1385
Query: 2873 SGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCG 2932
+G C+P W CD + DC D SDE G + C + C G C+P +CD +DCG
Sbjct: 1386 NGHCVPHGWLCDNQDDCGDGSDEE---GCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCG 1442
Query: 2933 DMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRT 2992
D +DE + C C D RC+P + +CDG DC D DE + T
Sbjct: 1443 DGTDEP------SYPCPQGLLACA-----DGRCLPPALLCDGHPDCLDAADEESCLGQVT 1491
Query: 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE----------------------RGCL-- 3028
C E +C G C+ I CD DC D +DE G L
Sbjct: 1492 CVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDT 1551
Query: 3029 ----------YQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPH 3078
C +F C +G C + + CD++ DC DGSDE C P C PH
Sbjct: 1552 ASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDE--RGCGGP---CAPH 1606
Query: 3079 EFKCDNG-RCIEMMKLCNHLDDCLDNSDE--KGCG 3110
C G C+ +LC+ + C D SDE CG
Sbjct: 1607 HAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACG 1641
Score = 114 bits (285), Expect = 2e-24
Identities = 99/343 (28%), Positives = 126/343 (36%), Gaps = 93/343 (27%)
Query: 2826 YTKCH-------NSNICIPRVYLCDGDNDCGDNSDENPTY---CTTH----------TCS 2865
+T CH + C+ CD DC TY C H CS
Sbjct: 1213 FTLCHAEVPPQQHYEWCLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCS 1272
Query: 2866 SSEFQCASGR------------CIPQH----WYCDQETDCFDASDEPASCGHSERTCLAD 2909
QC G+ C QH W+C Q C + C E T L
Sbjct: 1273 ---LQCEGGQVYEACGPTCPPTCHEQHPEPGWHC-QVVACVEG------CFCPEGTLL-- 1320
Query: 2910 EFKCDGGRCI-----PSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRR 2964
GG C+ P EW G N S K C N C + ++ C D
Sbjct: 1321 ----HGGACLEPASCPCEW---GRNSFPPGSVLQK--DCGNCTCQEGQWHCGGDGGHCEE 1371
Query: 2965 CIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE 3024
+P C +G C EN G C+P + CD +DCGD SDE
Sbjct: 1372 LVPA---------CAEG--------EALCQEN------GHCVPHGWLCDNQDDCGDGSDE 1408
Query: 3025 RGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDN 3084
GC C + Q TC +G C+ +CD +DCGDG+DE P CP C +
Sbjct: 1409 EGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDE-------PSYPCPQGLLACAD 1461
Query: 3085 GRCIEMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNC 3126
GRC+ LC+ DCLD +DE+ C G C +S D C
Sbjct: 1462 GRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTC 1504
Score = 106 bits (264), Expect = 6e-22
Identities = 113/422 (26%), Positives = 142/422 (33%), Gaps = 91/422 (21%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
C CA+ +C+P CDG DC D +DE + Q C G+ C DG C L
Sbjct: 1452 CPQGLLACADG-RCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQL 1510
Query: 3572 CNAHQNCPDGSDEDRLLC--------------------------------ENHHCDSNEW 3599
C+ +CPDG+DE C C E+
Sbjct: 1511 CDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEF 1570
Query: 3600 QCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANG-RCIPQAWKCDVDN 3658
+C + C P W+CD DC D SDE C P CA G C+ CD
Sbjct: 1571 RCGSGECTPRGWRCDQEEDCADGSDERG---CGGPCAPHHAPCARGPHCVSPEQLCDGVR 1627
Query: 3659 DCGDHSDEPIEECMSSAHL-CDNFT-----EFSCKTNYRCIPKWAVCNGVDDC------R 3706
C D SDE + C L N T E++C N CI VC+G DC
Sbjct: 1628 QCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTC-PNGTCIGFQLVCDGQPDCGRPGQVG 1686
Query: 3707 DNSDEQGCE-----------ERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA 3755
+ +EQGC RTC P G R + C PL QN G + C
Sbjct: 1687 PSPEEQGCGAWGPWSPWGPCSRTCGPWGQGR--SRRCSPLGLLV-LQNCPGPEHQSQACF 1743
Query: 3756 PREC-TESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCH-PEYFQCTSG----- 3808
C + E+ S W ++ C + R CH P+ T
Sbjct: 1744 TAACPVDGEW---------STW--SPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGG 1792
Query: 3809 -HCVHSELKCDGSADCLDASDEADC--PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDD 3865
H C D A C F A C T + V PP W C G
Sbjct: 1793 LHSTRQTKPCP-----QDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPC-GSP 1846
Query: 3866 DC 3867
C
Sbjct: 1847 GC 1848
Score = 99.8 bits (247), Expect = 6e-20
Identities = 65/208 (31%), Positives = 83/208 (39%), Gaps = 45/208 (21%)
Query: 127 CDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI---C 183
C CP N + Q C N C C D +C E+ C
Sbjct: 1325 CLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHC--------GGDGGHCEELVPAC 1376
Query: 184 LHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCD 242
E C NG C+P ++CD+ +DC DGSDE C P CG Q TC SG C+ +CD
Sbjct: 1377 AEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCD 1436
Query: 243 GEDDCKDNGDE-------------DG--------CESGPHDVH-----------KCSPRE 270
+DDC D DE DG C+ P + C P E
Sbjct: 1437 RQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGE 1496
Query: 271 WSCPESGRCISIYKVCDGILDCPGREDE 298
SC + G C+ ++CDG+ DCP DE
Sbjct: 1497 VSCVD-GTCLGAIQLCDGVWDCPDGADE 1523
Score = 86.3 bits (212), Expect = 7e-16
Identities = 101/414 (24%), Positives = 148/414 (35%), Gaps = 82/414 (19%)
Query: 4 GPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63
GP+ + + +A +PA C FRCGSG C P WRCD +DC+D +DE GC
Sbjct: 1543 GPSPGSLDTASSPLASASPAP--PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG 1600
Query: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDC----------SQSTCSSHQI 113
C + C C+ +CD + C DGSDE D +++ +
Sbjct: 1601 -GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEY 1659
Query: 114 TCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDS 173
TC NG CI + CD DC P+ E+ C ++ C
Sbjct: 1660 TCPNGTCIGFQLVCDGQPDCGRPGQVG----PSPEEQGCGAWGPWSPWGPCSRTCGPWGQ 1715
Query: 174 SDEINCTEICLHNEFSCGNGECIPRA---YVCDHDNDCQDGSDEHACNYPTCGGY--QFT 228
C+ + L +C E +A C D + S C+ P G Q
Sbjct: 1716 GRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQ 1775
Query: 229 CPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDG 288
C S + +G C G H + P CP+ G
Sbjct: 1776 CHSPQ--------NGGRTCA------ALPGGLHSTRQTKP----CPQDG----------- 1806
Query: 289 ILDCPGREDENNTSTGKY-------CSMTLCSALNCQYQC-HETPYGG-ACFCPPGYIIN 339
CP N T +G+ C +T C ++ Q C + P G C+CP G ++
Sbjct: 1807 ---CP-----NATCSGELMFQPCAPCPLT-CDDISGQVTCPPDWPCGSPGCWCPEGQVLG 1857
Query: 340 HND----SRTC-VEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKAN 388
R C D + W K + + LC C++G R + C+ N
Sbjct: 1858 SEGWCVWPRQCPCLVDGARYWPGQRIKADCQ----LCICQDG----RPRRCRLN 1903
Score = 80.1 bits (196), Expect = 5e-14
Identities = 58/201 (28%), Positives = 72/201 (35%), Gaps = 47/201 (23%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHT------------------- 2740
C +C +G C+ CD DC DG+DE C L +
Sbjct: 1492 CVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDT 1551
Query: 2741 -------------CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFM 2787
C P F C +G C +RCD DC DGSDE GC C
Sbjct: 1552 ASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPC 1610
Query: 2788 CNNRRCIPREFICNGVDNCHDNNTSDEKNC--------PDRT---CQSGYTKCHNSNICI 2836
C+ E +C+GV C D + C P+RT C YT C N CI
Sbjct: 1611 ARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPE-YT-CPNGT-CI 1667
Query: 2837 PRVYLCDGDNDCGDNSDENPT 2857
+CDG DCG P+
Sbjct: 1668 GFQLVCDGQPDCGRPGQVGPS 1688
Score = 70.5 bits (171), Expect = 4e-11
Identities = 94/390 (24%), Positives = 129/390 (33%), Gaps = 137/390 (35%)
Query: 1106 PASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN--------------------- 1144
P C Q C+ C+ + VCD DC DGSDE++C
Sbjct: 2388 PVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPF 2447
Query: 1145 ------------STETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQF 1192
S C PSQ +C + C+ CD DC DGSDE GCV +C + +
Sbjct: 2448 MMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCV-DCVLAPW 2506
Query: 1193 KCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDG 1252
S +R G+ + E P P G C D F+ Q
Sbjct: 2507 SVWSS------CSRSCGL-GLTFQRQELLRPPLPGGSCPRDRFRSQ-------------- 2545
Query: 1253 HPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAW-LCDRDNDCGDMSDEKDCPTQPFR 1311
+C + CP + + AW C G S ++ C P +
Sbjct: 2546 ------------SCFVQACPVA-----GAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPK 2588
Query: 1312 -----CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTD--------ESPLCNGN------- 1351
CP + C G+ C GTD + LC
Sbjct: 2589 NGGAPCPGASQE----------RAPC-GLQPCSGGTDCELGRVYVSADLCQKGLVPPCPP 2637
Query: 1352 SCSD--FNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECD-------------- 1395
SC D N C+ CV+ C CP G LL +D++ C + EC
Sbjct: 2638 SCLDPKANRSCSGHCVE-----GCRCPPGLLL-HDTR-CLPLSECPCLVGEELKWPGVSF 2690
Query: 1396 ILGSCSQHCYNMRGSFRCSCDTGYMLESDG 1425
+LG+CSQ C C+ G +L G
Sbjct: 2691 LLGNCSQ----------CVCEKGELLCQPG 2710
Score = 68.9 bits (167), Expect = 1e-10
Identities = 39/112 (34%), Positives = 45/112 (40%), Gaps = 32/112 (28%)
Query: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCG-------------------- 1061
P QCG PC+ CV +CDG +DC D SDE+ C
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 1062 ------------TLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
CS S +CG GEC+ A RCD R DC DGSDE C
Sbjct: 2447 FMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 62.8 bits (151), Expect = 8e-09
Identities = 35/111 (31%), Positives = 49/111 (44%), Gaps = 34/111 (30%)
Query: 65 VTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQ----------------------- 101
V C G C+ G C+ + VCD +DC DGSDER
Sbjct: 2389 VQCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPF 2447
Query: 102 ----------DCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
S++ CS Q++C +G+C+ +E RCD DC DG+DE+ C
Sbjct: 2448 MMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 58.9 bits (141), Expect = 1e-07
Identities = 36/114 (31%), Positives = 46/114 (40%), Gaps = 34/114 (29%)
Query: 2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE----------MESVCALHT-------- 2740
+CG C C+ + CD DC DGSDE + S+ AL
Sbjct: 2390 QCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMM 2449
Query: 2741 --------------CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDC 2780
CSP+ +C +G C+ RCD DC DGSDE GC+ DC
Sbjct: 2450 PTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCV--DC 2501
Score = 56.6 bits (135), Expect = 6e-07
Identities = 74/320 (23%), Positives = 95/320 (29%), Gaps = 96/320 (30%)
Query: 3756 PRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRT------------------ 3797
P +C + C C+ +CD DC D SDER C
Sbjct: 2388 PVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPF 2447
Query: 3798 ----------------CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY 3841
C P C SG C+ +E +CD DC D SDE DG
Sbjct: 2448 MMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE--------DG-- 2497
Query: 3842 CQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCL--DVPCNSPNRFRCDNNRCIYS 3899
C + V P CG G + L +P S R R + C
Sbjct: 2498 -------CVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQ 2550
Query: 3900 HEVCNGV-----------DDCGDGTDETEEHCRKPTPK----PC---TEYEYKCGNGHCI 3941
G CG G + C P PK PC ++ CG
Sbjct: 2551 ACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGL---- 2606
Query: 3942 PHDNVCDDADDCGDWSDELG--------CNKGKERTCAENICEQNCTQLNEGGFI--CSC 3991
C DC ELG C KG C + + + G + C C
Sbjct: 2607 ---QPCSGGTDC-----ELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVEGCRC 2658
Query: 3992 TAGFETNVFDRTSCLDINEC 4011
G + T CL ++EC
Sbjct: 2659 PPGL---LLHDTRCLPLSEC 2675
Score = 55.8 bits (133), Expect = 1e-06
Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 35/104 (33%)
Query: 149 QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE--------------------------- 181
Q C+ C +Q CD + DC D SDE +C
Sbjct: 2395 QTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMAL 2454
Query: 182 --------ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
+C ++ SCG+GEC+ CD DCQDGSDE C
Sbjct: 2455 PGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 54.7 bits (130), Expect = 2e-06
Identities = 32/114 (28%), Positives = 42/114 (36%), Gaps = 9/114 (7%)
Query: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQ 3612
C GQ C C +C+ ++C DGSDE HC N +P W
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDE-------RHCARNLLMWLPS--LPALWA 2441
Query: 3613 CDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
T + C P Q C +G C+ +CD+ DC D SDE
Sbjct: 2442 ASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Score = 54.3 bits (129), Expect = 3e-06
Identities = 36/108 (33%), Positives = 45/108 (41%), Gaps = 38/108 (35%)
Query: 1074 CGHGE-------CIPAHWRCDKRNDCVDGSDEHNC------------------------P 1102
CG G+ C+ CD R DC+DGSDE +C P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 1103 THA----PAS---CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
T A PAS C +Q +C + +C+S CD DC DGSDE C
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 52.8 bits (125), Expect = 8e-06
Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 25/139 (17%)
Query: 2654 PCEQFNGGC-SHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNG-R 2711
PC F C S C P +C E + ++ + C G C C+ G
Sbjct: 1564 PCGPFEFRCGSGECTP----RGWRCDQEEDCADGSDERGC----GGPCAPHHAPCARGPH 1615
Query: 2712 CISEEWKCDNDNDCGDGSDEMESVC----ALHTCSPTA-----FTCANGRCVQYSYRCDY 2762
C+S E CD C DGSDE C AL + T +TC NG C+ + CD
Sbjct: 1616 CVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDG 1675
Query: 2763 YNDC------GDGSDEAGC 2775
DC G +E GC
Sbjct: 1676 QPDCGRPGQVGPSPEEQGC 1694
Score = 52.8 bits (125), Expect = 8e-06
Identities = 34/108 (31%), Positives = 42/108 (38%), Gaps = 30/108 (27%)
Query: 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE-------LMHLCHTPE-----------P 3073
C Q C+ C+ + VCD DC DGSDE LM L P P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 3074 T------------CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
T C P + C +G C+ + C+ DC D SDE GC
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 52.8 bits (125), Expect = 8e-06
Identities = 30/97 (30%), Positives = 38/97 (39%), Gaps = 33/97 (34%)
Query: 2965 CIPQSWVCDGDVDCTDGYDENQ---------------------------------NCTRR 2991
C+ Q+ VCDG DC DG DE +R
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRA 2462
Query: 2992 TCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCL 3028
CS ++ +CG G C+ RCD DC D SDE GC+
Sbjct: 2463 LCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCV 2499
Score = 52.4 bits (124), Expect = 1e-05
Identities = 79/355 (22%), Positives = 108/355 (30%), Gaps = 122/355 (34%)
Query: 108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC----------------------QYP 145
C Q C C+ CD DC DG+DE C P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 146 TC--------------EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL------- 184
T QL+C +G C + ++CD + DC+D SDE C + L
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWS 2510
Query: 185 HNEFSCGNGECIPRAYV---------CDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCI 235
SCG G R + C D AC P G + G C
Sbjct: 2511 SCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQAC--PVAGAWAMWEAWGPCS 2568
Query: 236 YQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGR 295
C G + D P + +P + E C G+ C G
Sbjct: 2569 VS---CGGGHQSRQRSCVD-----PPPKNGGAPCPGASQERAPC--------GLQPCSGG 2612
Query: 296 EDENNTSTGK-YCSMTLC----------------SALNCQYQCHETPYGGACFCPPGYII 338
D G+ Y S LC + +C C E C CPPG ++
Sbjct: 2613 TD---CELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVE-----GCRCPPGLLL 2664
Query: 339 NHNDSRTCVEFDDCQ--------------IWGICDQKCESRPGRHLCHCEEGYIL 379
+D+R C+ +C + G C Q C CE+G +L
Sbjct: 2665 --HDTR-CLPLSECPCLVGEELKWPGVSFLLGNCSQ----------CVCEKGELL 2706
Score = 48.1 bits (113), Expect = 2e-04
Identities = 20/41 (48%), Positives = 24/41 (58%)
Query: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
PAS C + CGSG C+ A+ RCD DC D +DE GC
Sbjct: 2458 PASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 47.4 bits (111), Expect = 3e-04
Identities = 36/126 (28%), Positives = 44/126 (34%), Gaps = 11/126 (8%)
Query: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI 2877
P C G T C C+ + +CDG DC D SDE H + S +
Sbjct: 2387 PPVQCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDER------HCARNLLMWLPS---L 2436
Query: 2878 PQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
P W P S C + C G C+ +E CD DC D SDE
Sbjct: 2437 PALWAASTVPFMMPTMALPGLPA-SRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Query: 2938 DKRHQC 2943
D C
Sbjct: 2496 DGCVDC 2501
Score = 45.8 bits (107), Expect = 0.001
Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 4/49 (8%)
Query: 208 CQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
C+ GS P C G C SG C+ + CDG DC+D DE+GC
Sbjct: 2224 CEPGSPPA----PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 45.1 bits (105), Expect = 0.002
Identities = 32/113 (28%), Positives = 39/113 (34%), Gaps = 34/113 (30%)
Query: 1226 PPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN------------------ACV 1267
PP C + C+ G C+ CDG DCL GSDE + + V
Sbjct: 2387 PPVQCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTV 2445
Query: 1268 P---------------KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
P C S C +G C+ CD DC D SDE C
Sbjct: 2446 PFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 44.3 bits (103), Expect = 0.003
Identities = 27/94 (28%), Positives = 35/94 (37%), Gaps = 33/94 (35%)
Query: 3525 CIPIWWKCDGQKDCSDGSDE-----------------------------LAL----CPQR 3551
C+ CDG++DC DGSDE +AL +
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRA 2462
Query: 3552 FCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDED 3585
C Q C G C S + C+ +C DGSDED
Sbjct: 2463 LCSPSQLSCGSGECLSAERRCDLRPDCQDGSDED 2496
Score = 43.9 bits (102), Expect = 0.004
Identities = 20/42 (47%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Query: 1187 CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPG 1228
C +CASG+ C+ CDGV DC D SDE GC P G
Sbjct: 2234 CPGVGLRCASGE-CVLRGGPCDGVLDCEDGSDEEGCVLLPEG 2274
Score = 43.1 bits (100), Expect = 0.006
Identities = 18/45 (40%), Positives = 22/45 (48%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYF 72
C RC SG C+ CDG DC D +DE GC ++ G F
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRF 2278
Score = 42.7 bits (99), Expect = 0.008
Identities = 109/483 (22%), Positives = 142/483 (29%), Gaps = 86/483 (17%)
Query: 972 NACNQPTHPNGDCS-----HFCFPVPNFQRVCGCPYGMRLASN-----------HLTCEG 1015
+AC P G C+ C +P Q C CP G+ + H + G
Sbjct: 4430 HACGSPCA--GLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNCWHTSAAG 4487
Query: 1016 DPTNEPPTE--QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
P + Q G C+ G C G+ + S+ CG SA
Sbjct: 4488 AGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGPC---LPPSALA 4544
Query: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQ----YTCDNHQC---ISKNW 1126
+ HW D + H CLD +T H C +S+
Sbjct: 4545 PASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGAPHLCTAPLSQQR 4604
Query: 1127 VCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGD------KDCVDGSDE 1180
+C C D CQ R + +C G ++ +G
Sbjct: 4605 LCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQESCNGGPC 4664
Query: 1181 VGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRP--PGMCHSDEFQCQ 1238
C T CA N+C C+D D C P PG C Q
Sbjct: 4665 PECEAQDTVFTLDCA---------NQCP--HSCADLWDRVQCLQGPCRPG-CRCPPGQLV 4712
Query: 1239 EDGICIPNFWECDGHPDCLYGSDEHNA-------------CVPKTCPSSYFHCDNGNCI- 1284
+DG C+P C G NA C TC + C + C
Sbjct: 4713 QDGRCVPI-------SSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPV 4765
Query: 1285 ---HRAWL-CDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPN 1340
AW C G M + C P P C NL C +CP
Sbjct: 4766 LGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQEC-NLQP-CP---ECPP 4820
Query: 1341 GTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC 1400
G S C ++ CVQEP C CP G LL N TC C C
Sbjct: 4821 GQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNG--TCVPPTAC----PC 4874
Query: 1401 SQH 1403
+QH
Sbjct: 4875 TQH 4877
Score = 42.0 bits (97), Expect = 0.014
Identities = 54/220 (24%), Positives = 78/220 (35%), Gaps = 45/220 (20%)
Query: 21 APASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQC 80
A ASG C HFR +G C+P D C + +G + + C+S C
Sbjct: 4959 ARASGCVCQPGHFRSQAGPCVPED-HC--------ECWHLGRPHLPGSEWQEACES-CLC 5008
Query: 81 IPNSWVCDQDQDCDDGSDERQDCSQSTCS-SHQITCSNGQCIPSEYRCDHVRDCPDGADE 139
+ VC Q CS TC+ ++ G C PS C A E
Sbjct: 5009 LSGRPVC------------TQHCSPLTCAQGEEMVLEPGSCCPS---------CRREAPE 5047
Query: 140 NDCQYPTCEQLT----CDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGEC 195
Q P+C+ LT G CY + + SS + E L ++ C +
Sbjct: 5048 E--QSPSCQLLTELRNFTKGTCYLDQVEVSYCSGYCPSSTHVMPEEPYLQSQCDCCSYRL 5105
Query: 196 IPRAYVCDHDNDCQDGSDE-------HACNYPTCGGYQFT 228
P + V + C G E H+C +C G F+
Sbjct: 5106 DPESPVRILNLRCLGGHTEPVVLPVIHSCQCSSCQGGDFS 5145
Score = 41.6 bits (96), Expect = 0.019
Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 6/73 (8%)
Query: 3071 PEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTL 3130
P P CP +C +G C+ C+ + DC D SDE+GC + P +G H+ TL
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLL----PEGTGRFHSTAKTL 2285
Query: 3131 TSFYCSCRPGYKL 3143
S +PG L
Sbjct: 2286 A--LSSAQPGQLL 2296
Score = 40.8 bits (94), Expect = 0.032
Identities = 16/42 (38%), Positives = 24/42 (57%)
Query: 3071 PEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGIN 3112
P C P + C+ C+E ++C+ +DCLD SDE+ C N
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARN 2428
Score = 40.0 bits (92), Expect = 0.054
Identities = 19/46 (41%), Positives = 21/46 (45%)
Query: 1015 GDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
G PP C C +G CV CDGV DC D SDE+ C
Sbjct: 2223 GCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 40.0 bits (92), Expect = 0.054
Identities = 17/36 (47%), Positives = 19/36 (52%)
Query: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCL 2776
C CA+G CV CD DC DGSDE GC+
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 39.7 bits (91), Expect = 0.071
Identities = 26/102 (25%), Positives = 39/102 (38%), Gaps = 12/102 (11%)
Query: 3487 KGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELA 3546
+G+ C+ +D S C C+ CA C+ CDG + C DGSDE
Sbjct: 1580 RGWRCDQEED--CADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGP 1637
Query: 3547 LCPQRFCRLG----------QFQCSDGNCTSPQTLCNAHQNC 3578
LG ++ C +G C Q +C+ +C
Sbjct: 1638 DACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 39.7 bits (91), Expect = 0.071
Identities = 83/369 (22%), Positives = 117/369 (31%), Gaps = 87/369 (23%)
Query: 3466 SNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKC 3525
S PCG GG GG G D Q C P C Q L A C
Sbjct: 4776 SAPCG---GGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPC-PECPPGQVLSACATSC 4831
Query: 3526 IPIWWKCDG-----QKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL-CNAH---- 3575
+ W Q+ C G CP G +G C P C H
Sbjct: 4832 PCLCWHLQPGAICVQEPCQPGCG----CP------GGQLLHNGTCVPPTACPCTQHSLPW 4881
Query: 3576 ----------QNCPDGSDEDRLLCENHHCDSNEWQCANKRC-IP--ESWQ---------- 3612
Q P G+ R C C + C+ C +P E+WQ
Sbjct: 4882 GLTLTLEEQAQELPPGTVLTRN-CTRCVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLC 4940
Query: 3613 ---CDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIP----QAWKCDVDNDCGDHSD 3665
C N + S+ S+ + C+PG FR G C+P + W + G
Sbjct: 4941 EQTCLEMNATKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDHCECWHLGRPHLPGSEWQ 5000
Query: 3666 EPIEE--CMSSAHLC-DNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ---GCE---- 3715
E E C+S +C + + +C + + C CR + E+ C+
Sbjct: 5001 EACESCLCLSGRPVCTQHCSPLTCAQGEEMVLEPGSC--CPSCRREAPEEQSPSCQLLTE 5058
Query: 3716 -----ERTCH--PVGDFRCKNH-----HCIPLRWQCDGQNDCGDNSDEENCAPRECTESE 3763
+ TC+ V C + H +P Q DC C+ R ES
Sbjct: 5059 LRNFTKGTCYLDQVEVSYCSGYCPSSTHVMPEEPYLQSQCDC--------CSYRLDPESP 5110
Query: 3764 FRCVNQQCI 3772
R +N +C+
Sbjct: 5111 VRILNLRCL 5119
Score = 39.3 bits (90), Expect = 0.092
Identities = 15/28 (53%), Positives = 18/28 (64%)
Query: 190 CGNGECIPRAYVCDHDNDCQDGSDEHAC 217
C +GEC+ R CD DC+DGSDE C
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.5 bits (88), Expect = 0.16
Identities = 63/288 (21%), Positives = 87/288 (30%), Gaps = 60/288 (20%)
Query: 3544 ELALCPQRFCRLGQFQCSD---GNCTSPQTLCNAHQNCPDGS-DEDRLLCENHHCDSNEW 3599
E+ C R R +CSD G +C CP GS ++D HCD +
Sbjct: 4067 EVVTCANRCPR----RCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDA 4122
Query: 3600 QCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDND 3659
Q P S D N+C +C+ GQ C C P
Sbjct: 4123 Q--GHSWAPGSQHQDACNNC--------------SCQAGQLSCTAQPCPPPT-------H 4159
Query: 3660 CGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTC 3719
C C S + F T+ WA +CR+ E+
Sbjct: 4160 CAWSHWSAWSPCSHSCGPRGQQSRFRSSTS----GSWA-----PECRE-------EQSQS 4203
Query: 3720 HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQC-IPSRW-I 3777
P C C PL Q GD+ + C CT C + +C +P W +
Sbjct: 4204 QP-----CPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAVPEAWTL 4258
Query: 3778 CDHYNDC------GDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDG 3819
++DC G+ R C H C + C G
Sbjct: 4259 WSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPG 4306
Score = 38.1 bits (87), Expect = 0.21
Identities = 17/37 (45%), Positives = 19/37 (51%)
Query: 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL 1185
C C + C+ CDG DC DGSDE GCVL
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVL 2270
Score = 37.7 bits (86), Expect = 0.27
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 1/46 (2%)
Query: 3499 TLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE 3544
T+ L G +CS +Q C + E C+ +CD + DC DGSDE
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGE-CLSAERRCDLRPDCQDGSDE 2495
Score = 37.7 bits (86), Expect = 0.27
Identities = 41/185 (22%), Positives = 68/185 (36%), Gaps = 42/185 (22%)
Query: 53 CSDDADEIGCAV-VTCQQGYFKC-----QSEGQCIPNSWVCD----QDQDCDDGSDERQD 102
CSD + I C CQ+G +C + +G C+P CD Q GS +
Sbjct: 4079 CSDLQEGIVCQDDQVCQKGC-RCPKGSLEQDGGCVPIGH-CDCTDAQGHSWAPGSQHQDA 4136
Query: 103 CSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNG--ACYNT 160
C+ +C + Q++C+ C P + C A + + C G + + +
Sbjct: 4137 CNNCSCQAGQLSCTAQPCPPPTH-C---------AWSHWSAWSPCSHSCGPRGQQSRFRS 4186
Query: 161 SQKCDWKVDCRDSSDEI------NCTEICLHNEFS-----------CGNGECIPRAYVCD 203
S W +CR+ + +C +CL S C C P +C+
Sbjct: 4187 STSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVICE 4246
Query: 204 HDNDC 208
D +C
Sbjct: 4247 -DTEC 4250
Score = 37.4 bits (85), Expect = 0.35
Identities = 14/35 (40%), Positives = 20/35 (57%)
Query: 108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
C + C++G+C+ CD V DC DG+DE C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 36.6 bits (83), Expect = 0.60
Identities = 20/47 (42%), Positives = 23/47 (48%), Gaps = 6/47 (12%)
Query: 3713 GCEERT-----CHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
GCE + C VG RC + C+ CDG DC D SDEE C
Sbjct: 2223 GCEPGSPPAPLCPGVG-LRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 36.6 bits (83), Expect = 0.60
Identities = 16/39 (41%), Positives = 19/39 (48%)
Query: 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQP 1309
CP C +G C+ R CD DC D SDE+ C P
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLP 2272
Score = 36.6 bits (83), Expect = 0.60
Identities = 105/450 (23%), Positives = 138/450 (30%), Gaps = 121/450 (26%)
Query: 19 CLAPASGQ---ECDSAHFRCGSGHCIP-ADWRCDGTKDCSDDADEIGCAVVTCQQGYFKC 74
C P SG A CG G P A C+G C Q F
Sbjct: 4627 CQVPCSGGFRLRWREAEALCGGGCREPWAQESCNGGP----------CPECEAQDTVFTL 4676
Query: 75 QSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCP 134
QC P+S C D D R C Q C C GQ + + RC + C
Sbjct: 4677 DCANQC-PHS--------CADLWD-RVQCLQGPCRPG-CRCPPGQLV-QDGRCVPISSCR 4724
Query: 135 DGADENDCQYPTCE----QLTCDNGACYNTSQKCDWKVDC-------RDSSDEINCTEIC 183
G + + QL C N C N S C + +C SS C
Sbjct: 4725 CGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQ-ECPVLGPWSAWSSCSAPCGGGT 4783
Query: 184 LHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGR--------CI 235
+ +C G P C QD CN C CP G+ C
Sbjct: 4784 MERHRTCEGG---PGVAPC----QAQDTEQRQECNLQPCP----ECPPGQVLSACATSCP 4832
Query: 236 YQNWVCDGEDDCKDNGDEDGCE-SGPHDVHK--CSPREWSCPES------GRCISIYK-- 284
W C + GC G +H C P +CP + G +++ +
Sbjct: 4833 CLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVP-PTACPCTQHSLPWGLTLTLEEQA 4891
Query: 285 ----------------VCDG------ILDC--PGREDENNTSTGK--YCSMTL--CSALN 316
VC G ++DC P E + G+ C T +A
Sbjct: 4892 QELPPGTVLTRNCTRCVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLCEQTCLEMNATK 4951
Query: 317 CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGI---------CDQKCES--- 364
Q C G C C PG+ + + CV D C+ W + + CES
Sbjct: 4952 TQSNCSSARASG-CVCQPGHF--RSQAGPCVPEDHCECWHLGRPHLPGSEWQEACESCLC 5008
Query: 365 RPGRHLC--HCE-------EGYILERGQYC 385
GR +C HC E +LE G C
Sbjct: 5009 LSGRPVCTQHCSPLTCAQGEEMVLEPGSCC 5038
Score = 36.2 bits (82), Expect = 0.78
Identities = 15/35 (42%), Positives = 16/35 (45%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
C C GEC+ CD DC DGSDE C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 35.8 bits (81), Expect = 1.0
Identities = 16/39 (41%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 3925 PKP-CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
P P C +C +G C+ CD DC D SDE GC
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 35.8 bits (81), Expect = 1.0
Identities = 17/36 (47%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 3804 QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDG 3839
+C SG CV CDG DC D SDE C P+G
Sbjct: 2240 RCASGECVLRGGPCDGVLDCEDGSDEEGC-VLLPEG 2274
Score = 35.4 bits (80), Expect = 1.3
Identities = 16/35 (45%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE 3544
P+C CA+ E C+ CDG DC DGSDE
Sbjct: 2232 PLCPGVGLRCASGE-CVLRGGPCDGVLDCEDGSDE 2265
Score = 35.4 bits (80), Expect = 1.3
Identities = 73/350 (20%), Positives = 105/350 (30%), Gaps = 105/350 (30%)
Query: 2649 QQCNNPCEQFNGGCSHICAPGPNGAE--CQCP-----HEGNWYLANNRKHC--------- 2692
Q C C+ + G +C PG G + C CP +G L HC
Sbjct: 3540 QPCPRSCQDLSPGS--VCQPGSVGCQPTCGCPLGQLSQDG---LCVPPAHCRCQYQPGAM 3594
Query: 2693 -IVDNGERCGASSFT--------------CSNGRCISEEWKCDNDNDCGD---------- 2727
I +N R S F+ C N C++ +C DC D
Sbjct: 3595 GIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPW 3654
Query: 2728 --------GSDEMES-VCALHTCSPTA---FTCANGRCVQYSYRCD-YYNDCGDGSDEAG 2774
G +++ S CA C A TC+ C + Y +C G G
Sbjct: 3655 EDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPGE---G 3711
Query: 2775 CLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNI 2834
C F + T + C + C + CH CP+ T Q C
Sbjct: 3712 CPFSCAHVTQQVGCFSEGC---------EEGCH---------CPEGTFQHRLA-CVQECP 3752
Query: 2835 CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2894
C+ +L + P S + + G C
Sbjct: 3753 CVLTAWLLQ-ELGATIGDPGQPLGPGDELDSGQTLRTSCGNC------------------ 3793
Query: 2895 EPASCGHSERTCLADE-FKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQC 2943
SC H + +C D+ F+ DGG S W CG + + QC
Sbjct: 3794 ---SCAHGKLSCSLDDCFEADGGFGPWSPW-GPCSRSCGGLGTRTRSRQC 3839
Score = 34.7 bits (78), Expect = 2.3
Identities = 24/72 (33%), Positives = 31/72 (43%), Gaps = 14/72 (19%)
Query: 3650 QAWKCDVDNDCGDHSDEPI-------EECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGV 3702
+ W DV HSD P+ E A LC C + C+ + C+GV
Sbjct: 2204 RVWPHDVH-----HSDVPLQVELLGCEPGSPPAPLCPG-VGLRCASG-ECVLRGGPCDGV 2256
Query: 3703 DDCRDNSDEQGC 3714
DC D SDE+GC
Sbjct: 2257 LDCEDGSDEEGC 2268
Score = 34.7 bits (78), Expect = 2.3
Identities = 97/435 (22%), Positives = 134/435 (30%), Gaps = 76/435 (17%)
Query: 3484 PGGKGFTCE---CPDDFRTLQLSGSTY--CMPMCSSTQFLCANNEKCIPIWWKCDGQKDC 3538
P +G C+ CP T + G+ Y C P C + C + C+ W+C C
Sbjct: 3294 PRAQGEVCQALPCPVTNCTA-IEGAEYSPCGPPCPRS---CDDLVHCV---WRCQPGCYC 3346
Query: 3539 SDG---SDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCD 3595
G S A+C Q G C D T + A PDG C + C
Sbjct: 3347 PPGQVLSSNGAICVQP----GHCSCLD-LLTGQRHHPGARLARPDG-------CNHCTCL 3394
Query: 3596 SNEWQCANKRC-IPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCI---PQA 3651
C + C +P W C + + C S+ CR GQ R + C PQ
Sbjct: 3395 EGRLNCTDLPCPVPGGW-CPW---------SEWTMC-SQPCR-GQTRSRSRACACPTPQH 3442
Query: 3652 WKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDE 3711
+ G+ + E C ++ +C + P W + D C S
Sbjct: 3443 GGAPCTGEAGEAGAQHQREA------CPSYA--TCPVDGAWGP-WGPWSPCDMCLGQSHR 3493
Query: 3712 QGCEERTCHPVGDFRCKNHH-----CIPLRWQCDGQNDCGDNSDEENCA---PRECTESE 3763
R P G C +H C QC DCG C PR C +
Sbjct: 3494 SRACSRPPTPEGGRPCPGNHTQSRPCQENSTQC---TDCGGGQSLHPCGQPCPRSCQDLS 3550
Query: 3764 FRCVNQQCIPSRWICDHYNDC--GDNSDERDCEMRT-CHPEYFQCTSGHCVHSELKCDGS 3820
V C P C C G S + C C +Y G +
Sbjct: 3551 PGSV---CQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSR 3607
Query: 3821 ADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPP--YWKC-----DGDDDCGDGSDE 3873
++ + + T D C A + +C+ P W D CG G
Sbjct: 3608 FSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQL 3667
Query: 3874 ELHLCLDVPCNSPNR 3888
C PC P R
Sbjct: 3668 RSRRCARPPCPGPAR 3682
Score = 34.3 bits (77), Expect = 3.0
Identities = 16/43 (37%), Positives = 18/43 (41%)
Query: 3832 CPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
C P C C + C+ CDG DC DGSDEE
Sbjct: 2224 CEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEE 2266
Score = 33.9 bits (76), Expect = 3.9
Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 15/96 (15%)
Query: 289 ILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVE 348
+ +C E + G C + ++C ++C C+CPPG +++ N + CV+
Sbjct: 3308 VTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQP-----GCYCPPGQVLSSNGA-ICVQ 3361
Query: 349 FDDCQIWGICDQKCESRPGRHL--------CHCEEG 376
C + + PG L C C EG
Sbjct: 3362 PGHCSCLDLLTGQ-RHHPGARLARPDGCNHCTCLEG 3396
Score = 33.9 bits (76), Expect = 3.9
Identities = 78/377 (20%), Positives = 111/377 (29%), Gaps = 120/377 (31%)
Query: 3735 LRWQ-----CDGQNDCGDNSDEENCAPRECTESEFR-------CVNQQCIPSRWICDHYN 3782
LRW+ C G C + +E+C C E E + C NQ C H
Sbjct: 4637 LRWREAEALCGG--GCREPWAQESCNGGPCPECEAQDTVFTLDCANQ--------CPH-- 4684
Query: 3783 DCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYC 3842
C D D C C P +C G V +C + C A+ A
Sbjct: 4685 SCADLWDRVQCLQGPCRPGC-RCPPGQLVQDG-RCVPISSCRCGLPSANASWEL---APA 4739
Query: 3843 QATMFECKNHVCIPPYWKCDGDD---------------DCGDGSDEELHLCLDVPCNSP- 3886
QA +C+N C+ C + CG G+ E C P +P
Sbjct: 4740 QAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPC 4799
Query: 3887 ------NRFRCDNNRC---------------------------IYSHEVCNGVDDCGDGT 3913
R C+ C I E C C G
Sbjct: 4800 QAQDTEQRQECNLQPCPECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQ 4859
Query: 3914 DETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAEN 3973
C PT PCT+ H +P W L + +
Sbjct: 4860 LLHNGTCVPPTACPCTQ--------HSLP-------------WGLTLTLEEQAQELPPGT 4898
Query: 3974 ICEQNCTQ--LNEGGFICSC-------------TAGFETNVFDRTSCLDINECEQFGTCP 4018
+ +NCT+ + G F CS A E + ++T CL++N + C
Sbjct: 4899 VLTRNCTRCVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLCEQT-CLEMNATKTQSNC- 4956
Query: 4019 QHCRNTKGSYECVCADG 4035
++ + CVC G
Sbjct: 4957 ----SSARASGCVCQPG 4969
Score = 33.5 bits (75), Expect = 5.1
Identities = 25/100 (25%), Positives = 38/100 (38%), Gaps = 23/100 (23%)
Query: 2646 NQKQQCNNPCEQ--FNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGE---RC 2700
+Q++ C + ++ G C+ AP G C P + L + + C + E C
Sbjct: 1585 DQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQ----LCDGVRQCPDGSDEGPDAC 1640
Query: 2701 GA--------------SSFTCSNGRCISEEWKCDNDNDCG 2726
G +TC NG CI + CD DCG
Sbjct: 1641 GGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCG 1680
Score = 33.5 bits (75), Expect = 5.1
Identities = 39/130 (30%), Positives = 43/130 (33%), Gaps = 19/130 (14%)
Query: 50 TKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCS 109
TK C D GC TC G Q C CDD S + C
Sbjct: 1799 TKPCPQD----GCPNATCS-GELMFQPCAPC---------PLTCDDISGQVTCPPDWPCG 1844
Query: 110 SHQITCSNGQCIPSEYRCDHVRDCP---DGADENDCQ--YPTCEQLTCDNGACYNTSQKC 164
S C GQ + SE C R CP DGA Q C+ C +G
Sbjct: 1845 SPGCWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRPRRCRLNP 1904
Query: 165 DWKVDCRDSS 174
D VDC SS
Sbjct: 1905 DCAVDCGWSS 1914
Score = 33.5 bits (75), Expect = 5.1
Identities = 16/43 (37%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 1102 PTHAPAS-CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
P PA C C + +C+ + CD DC DGSDE+ C
Sbjct: 2226 PGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 33.5 bits (75), Expect = 5.1
Identities = 13/32 (40%), Positives = 16/32 (50%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
C C++G C+ CD DC DGSDE
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 33.1 bits (74), Expect = 6.6
Identities = 22/67 (32%), Positives = 27/67 (40%), Gaps = 6/67 (8%)
Query: 255 GCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN-----TSTGKYCSM 309
GCE G C C SG C+ CDG+LDC DE TG++ S
Sbjct: 2223 GCEPGSPPAPLCPGVGLRCA-SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHST 2281
Query: 310 TLCSALN 316
AL+
Sbjct: 2282 AKTLALS 2288
Score = 33.1 bits (74), Expect = 6.6
Identities = 14/32 (43%), Positives = 17/32 (53%)
Query: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
C +CASG C+ + CD DC D SDE
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 33.1 bits (74), Expect = 6.6
Identities = 29/111 (26%), Positives = 38/111 (34%), Gaps = 23/111 (20%)
Query: 3469 CGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIP- 3527
C G C LCL + G G C + +C P C+ L +N C+P
Sbjct: 2898 CHQEGGPCPRLCLTQ--GPGIEC-------------TGFCAPGCTCPPGLFLHNASCLPR 2942
Query: 3528 --IWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCT-----SPQTL 3571
+ GQ S L C C G+ C+ C SP TL
Sbjct: 2943 SQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTL 2993
Score = 33.1 bits (74), Expect = 6.6
Identities = 25/91 (27%), Positives = 38/91 (41%), Gaps = 17/91 (18%)
Query: 2634 LSQPRGINTVVKNQKQQCNNPCEQFNGGC--SHICAPGPNGAECQCPHEGNWY-----LA 2686
LS PRG N Q C+ C +G +++C P +C C HEG+ Y +
Sbjct: 3109 LSAPRGTN-------QTCHPGCHCPSGMLLLNNVCVPTQ---DCPCAHEGHLYPPGSTVV 3158
Query: 2687 NNRKHCIVDNGERCGASSFTCSNGRCISEEW 2717
++C +G SS+ C+ G W
Sbjct: 3159 RPCENCSCVSGLIANCSSWPCAEGEPTWSPW 3189
Score = 33.1 bits (74), Expect = 6.6
Identities = 66/271 (24%), Positives = 90/271 (33%), Gaps = 66/271 (24%)
Query: 22 PASGQECDSAHFR-------------CGSGHCI-PADWRCDGTKDCSD-------DADEI 60
P G+ C H + CG G + P C + C D +
Sbjct: 3503 PEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQPCP--RSCQDLSPGSVCQPGSV 3560
Query: 61 GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCS--------QSTCSSHQ 112
GC TC + +G C+P + Q Q G E Q S +S
Sbjct: 3561 GCQP-TCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEV 3619
Query: 113 IT--CSNGQCIPSEYRCDHVRDCPD------GADENDCQYPTC---EQL---TCDNGAC- 157
+T C N C+ +C V DCPD DC +C EQL C C
Sbjct: 3620 VTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSV-SCGGGEQLRSRRCARPPCP 3678
Query: 158 --YNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEH 215
S+ C +V CR E C L+ E G G A+V +G +E
Sbjct: 3679 GPARQSRTCSTQV-CR----EAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEE- 3732
Query: 216 ACNYPTCGGYQF------TCPSGRCIYQNWV 240
C+ P G +Q CP C+ W+
Sbjct: 3733 GCHCPE-GTFQHRLACVQECP---CVLTAWL 3759
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 196 bits (498), Expect = 5e-49
Identities = 154/520 (29%), Positives = 213/520 (40%), Gaps = 129/520 (24%)
Query: 3540 DGSDELALCPQR-FCRLGQFQCSDG----NCTSPQTL-CNAHQNCPDGSDEDRLLCENHH 3593
DG D L P R FC + C N + P L C+ +N + S+ R+
Sbjct: 202 DGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQ 261
Query: 3594 -------CDSNE-WQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANG 3645
C E + CA+ CIP QC+ +NDC+D SDE +HC C F C G
Sbjct: 262 ENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDE--AHC---NCSENLFHCHTG 316
Query: 3646 RCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDC 3705
+C+ + CD +DCGD SDE + C C+ TE C RCI VC+G DC
Sbjct: 317 KCLNYSLVCDGYDDCGDLSDE--QNCD-----CNPTTEHRCGDG-RCIAMEWVCDGDHDC 368
Query: 3706 RDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA--PRECTESE 3763
D SDE C +CH G C+N CIP +QCDG DC D SDEENC+ C E +
Sbjct: 369 VDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGD 425
Query: 3764 FRCVNQQCIPSRWICDHYNDCGDNSDERDCEM---------------RTCHPEYF----- 3803
RC+ C+ S C + C N+ +C T +P YF
Sbjct: 426 QRCLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQ 482
Query: 3804 ----------------------------------QC---TSGH-------CVHSELKCDG 3819
+C T H C HS+ +C+
Sbjct: 483 KEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCES 542
Query: 3820 SADC--LDASDEADCPTRFPDG--------------AYCQATMFECKNHVCIPPYWKCDG 3863
L ++ DC ++FP+ C + F+C++ C+ +CDG
Sbjct: 543 VLGIVGLQWPEDTDC-SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDG 601
Query: 3864 DDDCGDGSDEELHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRK 3922
DC D SDEE + C + + C +N+ C+ +C+G DC D DE ++C
Sbjct: 602 QADCDDDSDEE-----NCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNCSF 654
Query: 3923 PTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
C + E +C N C+ D CD DC D SDE C
Sbjct: 655 -----CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 181 bits (459), Expect = 2e-44
Identities = 141/453 (31%), Positives = 189/453 (41%), Gaps = 95/453 (20%)
Query: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
FLCA+ CIP +C+G DC D SDE A C C F C G C + +C+ +
Sbjct: 275 FLCASGI-CIPGKLQCNGYNDCDDWSDE-AHCN---CSENLFHCHTGKCLNYSLVCDGYD 329
Query: 3577 NCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCR 3636
+C D SDE C + E +C + RCI W CD +DC D SDE + C S+
Sbjct: 330 DCGDLSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQ--- 382
Query: 3637 PGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKT-NYRCI-- 3693
G C NG+CIP ++CD D DC D SDE E C + + SC+ + RC+
Sbjct: 383 -GLVECRNGQCIPSTFQCDGDEDCKDGSDE--ENC--------SVIQTSCQEGDQRCLYN 431
Query: 3694 PKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEE- 3752
P C G C N+ C + C P+ C N +P N G + +E
Sbjct: 432 PCLDSCGGSSLCDPNNSLNNCSQ--CEPITLELCMN---LPYN-STSYPNYFGHRTQKEA 485
Query: 3753 ---------------NCAPR----ECTESEFRC---VNQQCIPSRWICDHY--------- 3781
NC CT +C + P R +C+H
Sbjct: 486 SISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLG 545
Query: 3782 ---------NDCG----DNSDERDCEM-----RTCHPEYFQCTSGHCVHSELKCDGSADC 3823
DC +NSD + C M C P +F+C SG CV + +CDG ADC
Sbjct: 546 IVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADC 605
Query: 3824 LDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVP 3882
D SDE +C + D C + +C H I CDG DC D DE+ C D
Sbjct: 606 DDDSDEENCGCKERDLWECPSNK-QCLKHTVI-----CDGFPDCPDYMDEKNCSFCQD-- 657
Query: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
+ C N+ C+ C+G DC D +DE
Sbjct: 658 ----DELECANHACVSRDLWCDGEADCSDSSDE 686
Score = 162 bits (410), Expect = 7e-39
Identities = 128/439 (29%), Positives = 176/439 (40%), Gaps = 67/439 (15%)
Query: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCG-CPYGMRLASNHLTCEGDPTNEPPTEQCGLF 1029
S C P NG C NF G C G + + C D ++ C
Sbjct: 253 SRICFSPQQENGK-QLLCGRGENFLCASGICIPGKLQCNGYNDC--DDWSDEAHCNCSEN 309
Query: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKR 1089
F C G+C+ +CDG DDC D SDEQ C + ++ CG G CI W CD
Sbjct: 310 LFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC----DCNPTTEHRCGDGRCIAMEWVCDGD 365
Query: 1090 NDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET- 1148
+DCVD SDE NC H+ C N QCI + CD D DC DGSDE+NC+ +T
Sbjct: 366 HDCVDKSDEVNCSCHSQG-----LVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
Query: 1149 CQPSQFNCPNHRCIDL---SFVCDGDKDCVDGSDEVGCVLN-CTASQFKCASGDKCIGVT 1204
CQ C + C+D S +CD + + S L C + S G
Sbjct: 421 CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR 480
Query: 1205 NRCDG-----------------------------VFDCSDNSDEAGCPTRPPGMCHSDEF 1235
+ + V C N+ E P R +C +
Sbjct: 481 TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCR--ALCEHSKE 538
Query: 1236 QCQE----DGICIPNFWECDGHPDCLYGSDEHNACVP----KTCPSSYFHCDNGNCIHRA 1287
+C+ G+ P +C P+ SD +P + C S+F C +G C+ +
Sbjct: 539 RCESVLGIVGLQWPEDTDCSQFPE--ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLAS 596
Query: 1288 WLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL 1347
CD DC D SDE++C + W+C + C+ +V+CDG DCP+ DE
Sbjct: 597 RRCDGQADCDDDSDEENCGCKERDL----WECPSNKQCLKHTVICDGFPDCPDYMDEK-- 650
Query: 1348 CNGNSCSDFNGGC-THECV 1365
N + C D C H CV
Sbjct: 651 -NCSFCQDDELECANHACV 668
Score = 151 bits (382), Expect = 1e-35
Identities = 145/528 (27%), Positives = 207/528 (39%), Gaps = 119/528 (22%)
Query: 2651 CNNPCEQFNGGCSHICA----PGPNGAECQCPHEGNWYLANNRKHCIV---DNGER--CG 2701
C + CE GC + P+ C +N + C +NG++ CG
Sbjct: 212 CRSFCEAAKEGCESVLGMVNYSWPDFLRCS-QFRNQTESSNVSRICFSPQQENGKQLLCG 270
Query: 2702 -ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
+F C++G CI + +C+ NDC D SDE CS F C G+C+ YS C
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC-----NCSENLFHCHTGKCLNYSLVC 325
Query: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNT--------- 2811
D Y+DCGD SDE C DCN TTE C + RCI E++C+G +C D +
Sbjct: 326 DGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQ 382
Query: 2812 --------------------------SDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCD 2843
SDE+NC +CQ G +C + P + C
Sbjct: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRC----LYNPCLDSCG 438
Query: 2844 GDNDCG-DNSDENPTYC---TTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPA-- 2897
G + C +NS N + C T C + + S H + + +++S PA
Sbjct: 439 GSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
Query: 2898 --SCGHSER--TCLADEFKCD---GGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSD 2950
+C +C KCD G P +C E + +C+
Sbjct: 499 QTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALC-----------EHSKERCE------ 541
Query: 2951 SEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN---QNCTR-----RTCSENEFTCGY 3002
S V + P+ D DC+ +EN Q C CS + F C
Sbjct: 542 SVLGIVGLQWPE------------DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRS 589
Query: 3003 GLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC-QNGRCISKTFVCDEDNDCGDGS 3061
G C+ RCD DC D SDE C + +++ + C N +C+ T +CD DC D
Sbjct: 590 GQCVLASRRCDGQADCDDDSDEENCGCK--ERDLWECPSNKQCLKHTVICDGFPDCPDYM 647
Query: 3062 DELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
DE C C E +C N C+ C+ DC D+SDE C
Sbjct: 648 DEKN--CSF----CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 149 bits (376), Expect = 6e-35
Identities = 123/414 (29%), Positives = 167/414 (40%), Gaps = 73/414 (17%)
Query: 2780 CNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRV 2839
C F+C + CIP + CNG ++C D SDE +C C CH C+
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDD--WSDEAHC---NCSENLFHCHTGK-CLNYS 322
Query: 2840 YLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASC 2899
+CDG +DCGD SDE C T E +C GRCI W CD + DC D SDE
Sbjct: 323 LVCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Query: 2900 GHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDR 2959
HS+ +C G+CIPS + CDGD DC D SDE+ NCS + C +
Sbjct: 379 CHSQGLV-----ECRNGQCIPSTFQCDGDEDCKDGSDEE--------NCSVIQTSC---Q 422
Query: 2960 PPDRRCI--PQSWVCDGDVDCTDGYDENQNC------TRRTC-----SENEFTCGYGLCI 3006
D+RC+ P C G C D + NC T C + + +G
Sbjct: 423 EGDQRCLYNPCLDSCGGSSLC-DPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRT 481
Query: 3007 PK---------IFRCDRHNDCGDYSDERGC--LYQTCQQN--------QFTCQNG--RCI 3045
K +F +C Y C L C N + C++ RC
Sbjct: 482 QKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCE 541
Query: 3046 SKTFVCD----EDNDCGDGSDELM--HLCHTPEP---TCPPHEFKCDNGRCIEMMKLCNH 3096
S + ED DC +E C P+ C P FKC +G+C+ + C+
Sbjct: 542 SVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDG 601
Query: 3097 LDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
DC D+SDE+ CG C + + C N + C P D++ C
Sbjct: 602 QADCDDDSDEENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
Score = 148 bits (374), Expect = 1e-34
Identities = 117/415 (28%), Positives = 175/415 (42%), Gaps = 76/415 (18%)
Query: 3491 CECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL-ALCP 3549
C+ DD L + C P +T+ C + +CI + W CDG DC D SDE+ C
Sbjct: 325 CDGYDDCGDLSDEQNCDCNP---TTEHRCGDG-RCIAMEWVCDGDHDCVDKSDEVNCSCH 380
Query: 3550 QRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPE 3609
+ G +C +G C C+ ++C DGSDE+ C + +C C+
Sbjct: 381 SQ----GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS 436
Query: 3610 ---SWQCD---TFNDCED--------------NSDEDSSHCASRTCRPGQFRCANG---- 3645
S CD + N+C NS ++ RT + +
Sbjct: 437 CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPA 496
Query: 3646 -------------RCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRC 3692
C KCDV+ G+H I C + LC++ E C++
Sbjct: 497 LVQTNCYKYLMFFSCTILVPKCDVNT--GEH----IPPCRA---LCEHSKE-RCESVLGI 546
Query: 3693 I----PKWAVCNGVDDCRDNSDEQGC-----EERTCHPVGDFRCKNHHCIPLRWQCDGQN 3743
+ P+ C+ + +NSD Q C C P F+C++ C+ +CDGQ
Sbjct: 547 VGLQWPEDTDCSQFPE--ENSDNQTCLMPDEYVEECSP-SHFKCRSGQCVLASRRCDGQA 603
Query: 3744 DCGDNSDEENCAPRECTESEFRC-VNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEY 3802
DC D+SDEENC +E + C N+QC+ ICD + DC D DE++C C +
Sbjct: 604 DCDDDSDEENCGCKE--RDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDE 659
Query: 3803 FQCTSGHCVHSELKCDGSADCLDASDEADCPT---RFPDGAYCQATMFECKNHVC 3854
+C + CV +L CDG ADC D+SDE DC T ++ ++HVC
Sbjct: 660 LECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVC 714
Score = 147 bits (370), Expect = 3e-34
Identities = 103/366 (28%), Positives = 138/366 (37%), Gaps = 109/366 (29%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87
C F C +G C+ CDG DC D +DE C C +G+CI WVC
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVC 362
Query: 88 DQDQDCDDGSDERQDCSQSTCSSHQ---ITCSNGQCIPSEYRCDHVRDCPDGADENDCQY 144
D D DC D SDE CS H + C NGQCIPS ++CD DC DG+DE +C
Sbjct: 363 DGDHDCVDKSDE------VNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Query: 145 --PTCEQ-----------------LTCDNGACYNTSQKCD-------------------- 165
+C++ CD N +C+
Sbjct: 417 IQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNY 476
Query: 166 ------------WKVDCRDSSDEINCTEICLHNEFSC---------GNGECIPRAY-VCD 203
W+ + + NC + + FSC GE IP +C+
Sbjct: 477 FGHRTQKEASISWESSLFPALVQTNCYKYLMF--FSCTILVPKCDVNTGEHIPPCRALCE 534
Query: 204 H------------------DNDC----QDGSDEHACNYPT-----CGGYQFTCPSGRCIY 236
H D DC ++ SD C P C F C SG+C+
Sbjct: 535 HSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVL 594
Query: 237 QNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE 296
+ CDG+ DC D+ DE+ C D+ W CP + +C+ +CDG DCP
Sbjct: 595 ASRRCDGQADCDDDSDEENCGCKERDL-------WECPSNKQCLKHTVICDGFPDCPDYM 647
Query: 297 DENNTS 302
DE N S
Sbjct: 648 DEKNCS 653
Score = 139 bits (351), Expect = 5e-32
Identities = 127/497 (25%), Positives = 193/497 (38%), Gaps = 139/497 (27%)
Query: 2648 KQQCN--NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHC----------IVD 2695
K QCN N C+ ++ + A C C + N HC + D
Sbjct: 286 KLQCNGYNDCDDWS-----------DEAHCNC--------SENLFHCHTGKCLNYSLVCD 326
Query: 2696 NGERCG------------ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSP 2743
+ CG + C +GRCI+ EW CD D+DC D SDE+ C+ H S
Sbjct: 327 GYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVN--CSCH--SQ 382
Query: 2744 TAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFI--CN 2801
C NG+C+ +++CD DC DGSDE C T ++RC+ + C
Sbjct: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV----IQTSCQEGDQRCLYNPCLDSCG 438
Query: 2802 GVDNCHDNNTSDE------------KNCP-DRTCQSGY---------------------- 2826
G C NN+ + N P + T Y
Sbjct: 439 GSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
Query: 2827 -TKCH------NSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGR-CIP 2878
T C+ + I +P+ C N+ E+ C C S+ +C S +
Sbjct: 499 QTNCYKYLMFFSCTILVPK---------CDVNTGEHIPPCRA-LCEHSKERCESVLGIVG 548
Query: 2879 QHWYCDQETDCFDASDEPASCGHSERTCLADE----------FKCDGGRCIPSEWICDGD 2928
W ++TDC +E + +TCL + FKC G+C+ + CDG
Sbjct: 549 LQW--PEDTDCSQFPEENSD----NQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQ 602
Query: 2929 NDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC 2988
DC D SDE +N C + + + P +++C+ + +CDG DC D DE +NC
Sbjct: 603 ADCDDDSDE------ENCGCKERDLW---ECPSNKQCLKHTVICDGFPDCPDYMDE-KNC 652
Query: 2989 TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKT 3048
+ C ++E C C+ + CD DC D SDE C+ + N + +
Sbjct: 653 S--FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVN-----SSSFLMVH 705
Query: 3049 FVCDEDNDCGDGSDELM 3065
E + C DG E++
Sbjct: 706 RAATEHHVCADGWQEIL 722
Score = 130 bits (327), Expect = 3e-29
Identities = 100/374 (26%), Positives = 150/374 (40%), Gaps = 68/374 (18%)
Query: 981 NGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQ--CGLFS---FPCKN 1035
N DC+ P + CG R + C+GD +++ C S C+N
Sbjct: 339 NCDCN------PTTEHRCG---DGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRN 389
Query: 1036 GRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDG 1095
G+C+P+ + CDG +DC D SDE+ C + +C C + C+ + C + C
Sbjct: 390 GQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPN 446
Query: 1096 SDEHNCPTHAPAS---CLDTQYTCDNH-----QCISKNWVCDTDNDCGDGSDEKNC---- 1143
+ +NC P + C++ Y ++ K ++ + NC
Sbjct: 447 NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYL 506
Query: 1144 --------------NSTETCQPSQFNCPN--HRCIDLSFVC----DGDKDC----VDGSD 1179
N+ E P + C + RC + + D DC + SD
Sbjct: 507 MFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSD 566
Query: 1180 EVGCVL------NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSD 1233
C++ C+ S FKC SG +C+ + RCDG DC D+SDE C G D
Sbjct: 567 NQTCLMPDEYVEECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENC-----GCKERD 620
Query: 1234 EFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRD 1293
++C + C+ + CDG PDC DE N C C N C+ R CD +
Sbjct: 621 LWECPSNKQCLKHTVICDGFPDCPDYMDEKNC---SFCQDDELECANHACVSRDLWCDGE 677
Query: 1294 NDCGDMSDEKDCPT 1307
DC D SDE DC T
Sbjct: 678 ADCSDSSDEWDCVT 691
Score = 125 bits (314), Expect = 1e-27
Identities = 73/210 (34%), Positives = 97/210 (46%), Gaps = 19/210 (9%)
Query: 53 CSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQ 112
C E G ++ + F C S G CIP C+ DCDD SDE + CS +
Sbjct: 256 CFSPQQENGKQLLCGRGENFLCAS-GICIPGKLQCNGYNDCDDWSDE----AHCNCSENL 310
Query: 113 ITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRD 172
C G+C+ CD DC D +DE +C + C +G C CD DC D
Sbjct: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVD 370
Query: 173 SSDEINCTEICLHNE--FSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCP 230
SDE+NC+ H++ C NG+CIP + CD D DC+DGSDE C+ Q +C
Sbjct: 371 KSDEVNCS---CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV-----IQTSCQ 422
Query: 231 SG--RCIYQNWV--CDGEDDCKDNGDEDGC 256
G RC+Y + C G C N + C
Sbjct: 423 EGDQRCLYNPCLDSCGGSSLCDPNNSLNNC 452
Score = 123 bits (308), Expect = 5e-27
Identities = 83/237 (35%), Positives = 108/237 (45%), Gaps = 32/237 (13%)
Query: 2889 CFDASDEPAS---CGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN 2945
CF E CG E F C G CIP + C+G NDC D SDE +
Sbjct: 256 CFSPQQENGKQLLCGRGEN------FLCASGICIPGKLQCNGYNDCDDWSDE------AH 303
Query: 2946 QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLC 3005
NCS++ F C + C+ S VCDG DC D DE QNC +E+ CG G C
Sbjct: 304 CNCSENLFHCHTGK-----CLNYSLVCDGYDDCGDLSDE-QNCDCNPTTEHR--CGDGRC 355
Query: 3006 IPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELM 3065
I + CD +DC D SDE C + Q C+NG+CI TF CD D DC DGSDE
Sbjct: 356 IAMEWVCDGDHDCVDKSDEVNCSCHS--QGLVECRNGQCIPSTFQCDGDEDCKDGSDE-- 411
Query: 3066 HLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGC 3122
C + +C + +C C++ C C N+ C ++C ++ C
Sbjct: 412 ENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNC--SQCEPITLELC 463
Score = 123 bits (308), Expect = 5e-27
Identities = 68/187 (36%), Positives = 98/187 (52%), Gaps = 13/187 (6%)
Query: 32 HFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQ 91
+F C SG CIP +C+G DC D +DE C C + F C + G+C+ S VCD
Sbjct: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHT-GKCLNYSLVCDGYD 329
Query: 92 DCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLT 151
DC D SDE Q+C + + H+ C +G+CI E+ CD DC D +DE +C + +
Sbjct: 330 DCGDLSDE-QNCDCNPTTEHR--CGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVE 386
Query: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPR---AYVCDHD 205
C NG C ++ +CD DC+D SDE NC+ I C + C C+ + +CD +
Sbjct: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPN 446
Query: 206 NDCQDGS 212
N + S
Sbjct: 447 NSLNNCS 453
Score = 106 bits (264), Expect = 6e-22
Identities = 59/148 (39%), Positives = 73/148 (49%), Gaps = 17/148 (11%)
Query: 1053 DNSDEQLC---GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASC 1109
+NSD Q C CS S F C G+C+ A RCD + DC D SDE NC C
Sbjct: 563 ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC------GC 616
Query: 1110 LDTQ-YTC-DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFV 1167
+ + C N QC+ +CD DC D DEKNC+ CQ + C NH C+
Sbjct: 617 KERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF---CQDDELECANHACVSRDLW 673
Query: 1168 CDGDKDCVDGSDEVGCV---LNCTASQF 1192
CDG+ DC D SDE CV +N +S F
Sbjct: 674 CDGEADCSDSSDEWDCVTLSINVNSSSF 701
Score = 102 bits (254), Expect = 9e-21
Identities = 49/125 (39%), Positives = 70/125 (56%), Gaps = 6/125 (4%)
Query: 19 CLAPASG-QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE 77
CL P +EC +HF+C SG C+ A RCDG DC DD+DE C ++ ++C S
Sbjct: 570 CLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK--ERDLWECPSN 627
Query: 78 GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGA 137
QC+ ++ +CD DC D DE+ +C S C ++ C+N C+ + CD DC D +
Sbjct: 628 KQCLKHTVICDGFPDCPDYMDEK-NC--SFCQDDELECANHACVSRDLWCDGEADCSDSS 684
Query: 138 DENDC 142
DE DC
Sbjct: 685 DEWDC 689
Score = 100 bits (249), Expect = 3e-20
Identities = 76/221 (34%), Positives = 99/221 (44%), Gaps = 21/221 (9%)
Query: 1174 CVDGSDEVGCVLNCTASQ-FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 1232
C E G L C + F CASG CI +C+G DC D SDEA C C
Sbjct: 256 CFSPQQENGKQLLCGRGENFLCASGI-CIPGKLQCNGYNDCDDWSDEAHC------NCSE 308
Query: 1233 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDR 1292
+ F C G C+ CDG+ DC SDE N P++ C +G CI W+CD
Sbjct: 309 NLFHC-HTGKCLNYSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDG 364
Query: 1293 DNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCN--G 1350
D+DC D SDE +C C S + C+ + CDG DC +G+DE C+
Sbjct: 365 DHDCVDKSDEVNC-----SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEEN-CSVIQ 418
Query: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDI 1391
SC + + C + + G LC L N S+ CE I
Sbjct: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ-CEPI 458
Score = 97.8 bits (242), Expect = 2e-19
Identities = 49/115 (42%), Positives = 60/115 (52%), Gaps = 11/115 (9%)
Query: 188 FSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDC 247
F C +G CIP C+ NDC D SDE CN C F C +G+C+ + VCDG DDC
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTGKCLNYSLVCDGYDDC 331
Query: 248 KDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTS 302
D DE C+ P H+C GRCI++ VCDG DC + DE N S
Sbjct: 332 GDLSDEQNCDCNPTTEHRCG--------DGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Score = 97.8 bits (242), Expect = 2e-19
Identities = 81/315 (25%), Positives = 130/315 (41%), Gaps = 66/315 (20%)
Query: 35 CGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQCIPNSWVCDQDQD 92
C +G CIP+ ++CDG +DC D +DE C+V+ +CQ+G +C C+ + C
Sbjct: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYN-PCLDS---CGGSSL 442
Query: 93 CDDGSDERQDCSQSTCSSHQITCS---NGQCIPSEYRCDHVRDC---------PDGADEN 140
CD ++ +CSQ + ++ + N P+ + ++ P N
Sbjct: 443 CDP-NNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTN 501
Query: 141 DCQY----------PTCEQLTCDN-----GACYNTSQKCD---------WK--VDC---- 170
+Y P C+ T ++ C ++ ++C+ W DC
Sbjct: 502 CYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFP 561
Query: 171 RDSSDEINC------TEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGG 224
++SD C E C + F C +G+C+ + CD DC D SDE C
Sbjct: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL 621
Query: 225 YQFTCPSGR-CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
++ CPS + C+ +CDG DC D DE C D +C+ + C+S
Sbjct: 622 WE--CPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECA--------NHACVSRD 671
Query: 284 KVCDGILDCPGREDE 298
CDG DC DE
Sbjct: 672 LWCDGEADCSDSSDE 686
Score = 94.4 bits (233), Expect = 2e-18
Identities = 61/170 (35%), Positives = 84/170 (49%), Gaps = 19/170 (11%)
Query: 28 CDSAHFRCGSG-HCIPADWRCDGTKDCS----DDADEIGCA-----VVTCQQGYFKCQSE 77
C+ + RC S + W D DCS +++D C V C +FKC+S
Sbjct: 533 CEHSKERCESVLGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRS- 589
Query: 78 GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQI-TC-SNGQCIPSEYRCDHVRDCPD 135
GQC+ S CD DCDD SDE ++C C + C SN QC+ CD DCPD
Sbjct: 590 GQCVLASRRCDGQADCDDDSDE-ENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPD 645
Query: 136 GADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLH 185
DE +C + ++L C N AC + CD + DC DSSDE +C + ++
Sbjct: 646 YMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSIN 695
Score = 90.9 bits (224), Expect = 3e-17
Identities = 51/160 (31%), Positives = 68/160 (42%), Gaps = 12/160 (7%)
Query: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQ--------STCSSHQITCSNG 118
C+ +C+S + W +D DC +E D CS C +G
Sbjct: 533 CEHSKERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSG 590
Query: 119 QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTC-DNGACYNTSQKCDWKVDCRDSSDEI 177
QC+ + RCD DC D +DE +C + C N C + CD DC D DE
Sbjct: 591 QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK 650
Query: 178 NCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
NC+ C +E C N C+ R CD + DC D SDE C
Sbjct: 651 NCS-FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 66.6 bits (161), Expect = 5e-10
Identities = 44/152 (28%), Positives = 61/152 (40%), Gaps = 28/152 (18%)
Query: 3007 PKIFRCDRHNDCGDYSDERGCLYQTCQQN----------QFTCQNGRCISKTFVCDEDND 3056
P RC + + + S+ + Q+N F C +G CI C+ ND
Sbjct: 235 PDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYND 294
Query: 3057 CGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGIN---- 3112
C D SDE C+ C + F C G+C+ +C+ DDC D SDE+ C N
Sbjct: 295 CDDWSDEAH--CN-----CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTE 347
Query: 3113 -ECHDPS------ISGCDHNCTDTLTSFYCSC 3137
C D + DH+C D CSC
Sbjct: 348 HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSC 379
Score = 56.2 bits (134), Expect = 7e-07
Identities = 51/191 (26%), Positives = 72/191 (37%), Gaps = 25/191 (13%)
Query: 222 CG-GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCI 280
CG G F C SG CI C+G +DC D DE C CS + C +G+C+
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC--------NCSENLFHC-HTGKCL 319
Query: 281 SIYKVCDGILDCPGREDEN----NTSTGKYCSMTLCSAL----NCQYQCHETPYGGACFC 332
+ VCDG DC DE N +T C C A+ + + C + C C
Sbjct: 320 NYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSC 379
Query: 333 PPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKAN---D 389
++ + + C D+ C+ C + E Q C N D
Sbjct: 380 HSQGLVECRNGQCIPSTFQCD----GDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD 435
Query: 390 SFGEASIIFSN 400
S G +S+ N
Sbjct: 436 SCGGSSLCDPN 446
Score = 47.8 bits (112), Expect = 3e-04
Identities = 31/104 (29%), Positives = 43/104 (41%), Gaps = 12/104 (11%)
Query: 1000 CPYGMRLASNHLTCEGDPT-----NEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDN 1054
CP + + + C+G P +E C C N CV CDG DC D+
Sbjct: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDS 683
Query: 1055 SDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
SDE C TL+ +SS+F + H + + C DG E
Sbjct: 684 SDEWDCVTLSINVNSSSF-------LMVHRAATEHHVCADGWQE 720
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 154 bits (388), Expect = 3e-36
Identities = 155/604 (25%), Positives = 231/604 (38%), Gaps = 128/604 (21%)
Query: 2979 TDGYDENQNCTRRTCSENEFTCGYGL--------------CIPKIFRCDRHNDCGDYSDE 3024
T G D N C R +FTC + C + C H C ++
Sbjct: 676 THGCDTNAAC--RPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGT 733
Query: 3025 RGCLYQTCQQNQFTCQNGRCISKTFVCDED--NDCGDGSDELMHLCHTPEPTCPPHEFKC 3082
C C + G C++ V D+ N C G +H C P+
Sbjct: 734 FRC---ECVEGYQFSDEGTCVA---VVDQRPINYCETG----LHNCDIPQ---------- 773
Query: 3083 DNGRCIEMMKLCNHLDDCLD--NSDEKGC-GINECHDPSISGCDHNCTDTLTSFYCSCRP 3139
+CI ++ CL + D + C ++EC PS D C +T SF C C+P
Sbjct: 774 -RAQCIYTGG-SSYTCSCLPGFSGDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
Query: 3140 GYKLMSDKRTCVD---------------------------------IDECTEMPFVCSQK 3166
GY+ D CV + EC +
Sbjct: 831 GYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQ 888
Query: 3167 CENVIGSYICKCAPGYLREPDGKTCRQN------SNIEP-------------------YL 3201
C G C C RE +G R S + P +L
Sbjct: 889 CHGSTG--YCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHL 946
Query: 3202 IFSNRYYLRNLTIDGYFY------SLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMF 3255
+F+ + L ++G + + ++ L FD V+K +YW D I R
Sbjct: 947 LFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRAS 1006
Query: 3256 LNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDAN 3315
L+ TII L + E +AVD + R ++W D+ LD + V+ L+G RR+L + +
Sbjct: 1007 LHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDL--- 1063
Query: 3316 NTFCFDNPRGLALHPQYGYLYWADWGH-RAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
NPRG+ G LYW DW I MDGTN+ +++ L PNG+T D
Sbjct: 1064 -----VNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDA 1118
Query: 3375 TNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN 3434
+ L W DA E + R +G L +PFA+T + +Y+TDW +V +
Sbjct: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALD 1177
Query: 3435 KYDGSNRQTLVNTTHRPFDIH-VYHPYRQ-PIVSNPCGTNNGGCSHLCLIKPGGKGFTCE 3492
+++T H+ ++ + Q P N C NNGGC+HLCL PG + TC
Sbjct: 1178 L--AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCR 1233
Query: 3493 CPDD 3496
CPD+
Sbjct: 1234 CPDN 1237
Score = 141 bits (356), Expect = 1e-32
Identities = 150/602 (24%), Positives = 239/602 (39%), Gaps = 84/602 (13%)
Query: 136 GADEND-CQYPTCEQLTCDNGACYNTSQKCDWKVD-CRDSSDEINCTEICLHNE--FSCG 191
G D N C+ Q TC+ + + + +D C + IC ++ F C
Sbjct: 678 GCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC- 736
Query: 192 NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS-GRCIY---QNWVCDGEDDC 247
EC+ Y + C D+ NY G + P +CIY ++ C C
Sbjct: 737 --ECV-EGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS----C 789
Query: 248 KD--NGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDC---PGREDENNTS 302
+GD C+ DV +C P C C + G C PG + +
Sbjct: 790 LPGFSGDGQACQ----DVDECQPSR--CHPDAFCYNT----PGSFTCQCKPGYQGD---- 835
Query: 303 TGKYCSMTLCSALNCQYQC-HETPYGGACF----CPPGYIINHNDSRTCVEFDDCQ-IWG 356
G C CQ++ H GA PPG + D+ C G
Sbjct: 836 -GFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTG 894
Query: 357 ICDQKCESRPGRHLCHCEEGYILERGQY----------CKANDSFGEASIIFSNGRDLLI 406
C C R GR + EG G + A I G LL
Sbjct: 895 YC--WCVDRDGREV----EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLF 948
Query: 407 GDIHGRSFRILVESQNRG-------------VAVGVAFHYHLQRVFWTDTVQNKVFSVDI 453
G+ R+ +E V +G+AF + V+WTD + + +
Sbjct: 949 AQT-GKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
Query: 454 NGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPR 513
+G ++ + +PE +AVD + I+ ++ ++RI++ LDG+ R L +L +PR
Sbjct: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPR 1067
Query: 514 GIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYW 573
GI D G L+++DW PK+E ++MDG+NR+ LV+ LG P G+T D S ++ W
Sbjct: 1068 GIVTDSVRGNLYWTDWN--RDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCW 1125
Query: 574 VDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTET 633
VD+ + E + R+ + G + +PF V+ + ++FTDW +V+ +
Sbjct: 1126 VDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISK 1182
Query: 634 NPQVYY-QASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSH-----RTDNDGLGF 687
+ R YG+T S + P N C NNGGC +C+ + R ++ LG
Sbjct: 1183 ETDAFQPHKQTRLYGITTALS-QCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGV 1241
Query: 688 RC 689
C
Sbjct: 1242 DC 1243
Score = 131 bits (330), Expect = 1e-29
Identities = 79/264 (29%), Positives = 138/264 (52%), Gaps = 11/264 (4%)
Query: 1468 IVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTD 1527
I+ + FD + ++W+D T+ A +G + + + E IA+D +GRN++WTD
Sbjct: 980 IIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD 1039
Query: 1528 YALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
L+ IEV+K+DG+ R VL +L NPRG+ D L+W+DW +P+IE + MDG
Sbjct: 1040 SNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN--LYWTDWNRDNPKIETSYMDG 1097
Query: 1587 SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPY 1646
+ R ++VQD + P GLT D + L ++D+ + + + + RR+ + +++P+
Sbjct: 1098 TNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPF 1154
Query: 1647 ALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAF 1706
A+T + ++Y+TD V+ + + Q L + S+ P N C+
Sbjct: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSV 1214
Query: 1707 SR--CSHLCLLSSQGPHFYSCVCP 1728
+ C+HLCL + P +C CP
Sbjct: 1215 NNGGCTHLCLAT---PGSRTCRCP 1235
Score = 130 bits (328), Expect = 2e-29
Identities = 76/264 (28%), Positives = 137/264 (51%), Gaps = 15/264 (5%)
Query: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDS 803
+G+ FD D ++++D+++ I + + G + + + E +A D + +N++WTDS
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 804 HYKSISVMRLADKTRRTVVQY-LNNPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGSHL 861
+ I V +L RR + + L NPR +V G L++TDW R KI ++ DG++
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 862 LPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAI 921
++ LG PNGL D +S+L WVDA ++ E RR+ +E + +PF +
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA--LEGLQYPFAVTS 1158
Query: 922 FGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNAC----NQP 977
+G++L+FTDW++ +++ + ++ + + A+ H ++ I T + C N
Sbjct: 1159 YGKNLYFTDWKMNSVVAL------DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
Query: 978 THPNGDCSHFCFPVPNFQRVCGCP 1001
+ NG C+H C P R C CP
Sbjct: 1213 SVNNGGCTHLCLATPG-SRTCRCP 1235
Score = 126 bits (316), Expect = 6e-28
Identities = 81/263 (30%), Positives = 126/263 (47%), Gaps = 8/263 (3%)
Query: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
+ ++ L +D V +Y+T +G+ A+L G T T+I +G+ +GIA D + R
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGR---ASLHGGEPT-TIIRQDLGSPEGIAVDHLGR 1033
Query: 2479 RIYYSDYLNQMINSMAEDGSNRTVIARVP--KPRAIVLDPCQGYLYWADWDT-HAKIERA 2535
I+++D I DG+ R V+ PR IV D +G LYW DW+ + KIE +
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
Query: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHA 2595
+ G R +V L +P+GLT D L WVDA R E + R + +
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYP 1153
Query: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
F +T YG+ +Y+TD + + A + ++ GI T + +Q Q +N C
Sbjct: 1154 FAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTAL-SQCPQGHNYC 1212
Query: 2656 EQFNGGCSHICAPGPNGAECQCP 2678
NGGC+H+C P C+CP
Sbjct: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
Score = 124 bits (311), Expect = 2e-27
Identities = 77/224 (34%), Positives = 114/224 (50%), Gaps = 18/224 (8%)
Query: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
P+GIAVD +GR+I+W+D RIEVAKLDG R+ L TDL P I + G ++WTD
Sbjct: 1023 PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTD 1082
Query: 4204 WGKE-PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
W ++ PKIE+++M+G +R ILV +DLG P GL+ D ++ ++ W D + E +
Sbjct: 1083 WNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS-QLCWVDAGTNRAECLNPSQP 1141
Query: 4263 DRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK---FGQGKKEKTLVVNPWLTQVR 4319
RR + P+++ + LY+ WK N ++T P Q R
Sbjct: 1142 SRRKALEGLQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH-KQTR 1194
Query: 4320 IFHQLRYNKSVP---NLCKQI---CSHLCLLRPGGYSCACPQGS 4357
++ P N C C+HLCL PG +C CP +
Sbjct: 1195 LYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNT 1238
Score = 110 bits (274), Expect = 4e-23
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 29/281 (10%)
Query: 2103 DVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFT 2162
D +YW D + + +I R G I+ +G GIAVD + N+++T
Sbjct: 986 DCVDKMVYWTDIT-----EPSIGRASLHGGEPTTIIRQDLGSP--EGIAVDHLGRNIFWT 1038
Query: 2163 NAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLD 2221
++ + IEV +++ T RRVL + + PR IV D L+W D+ + PKIE S++D
Sbjct: 1039 DSNLDR--IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
Query: 2222 CTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPY 2281
TNR +LV + + P GL D + WVD + + + + G +Y P+
Sbjct: 1097 GTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY--PF 1154
Query: 2282 GITVFENSIIWVDRNLKKI----FQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
+T + ++ + D + + SKE + +P R L +T S
Sbjct: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR-----LYGIT------TALS 1203
Query: 2338 PAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSD 2378
+N C NNGGC+HLC A PG T C C TL D
Sbjct: 1204 QCPQGHNYCSVNNGGCTHLCLATPGSRT--CRCPDNTLGVD 1242
Score = 85.9 bits (211), Expect = 9e-16
Identities = 73/277 (26%), Positives = 112/277 (40%), Gaps = 22/277 (7%)
Query: 1781 LDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTN 1839
+ + FD ++ +YW + I R G T + P +A+D + RN++ T+
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPE-GIAVDHLGRNIFWTD 1039
Query: 1840 PRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAK 1899
IEV L G R+ L D + P GI D RG LYW+D D+ K
Sbjct: 1040 SNLDRIEVAKLDGT--QRRVLFETD-----LVNPRGIVTDSVRGNLYWTDWNRDN---PK 1089
Query: 1900 IASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQ 1959
I ++ MDGT+ + L +L +T D +L W G E N R +
Sbjct: 1090 IETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG 1149
Query: 1960 LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDN-VPNLRGLQVYHRRNAAES 2018
L +P+ + + LY+TD + + +D A + + L G+ +
Sbjct: 1150 LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQG 1208
Query: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDN 2055
N CS N C +CL PG +C C PDN
Sbjct: 1209 HNYCSVNNGGCTHLCLATPGSR-TCRC-------PDN 1237
Score = 81.3 bits (199), Expect = 2e-14
Identities = 109/458 (23%), Positives = 167/458 (36%), Gaps = 95/458 (20%)
Query: 3915 ETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELG----CNK------ 3964
+T CR P P T++ +C G C D D+C + G CN
Sbjct: 680 DTNAACR---PGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
Query: 3965 ---------GKERTCAE-------NICEQN-----------CTQLNEGGFICSCTAGFET 3997
E TC N CE C + CSC GF
Sbjct: 736 CECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG 795
Query: 3998 NVFDRTSCLDINECEQFGTCPQ-HCRNTKGSYECVCADGFTSMSDR--PGK----RC--- 4047
D +C D++EC+ P C NT GS+ C C G+ R PG+ RC
Sbjct: 796 ---DGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHE 852
Query: 4048 ------AAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEE-YIQAVDYDWDPKDIGLSV 4100
AA + P +P + + + + Y VD D
Sbjct: 853 REHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDG--------- 903
Query: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
V G +R G P + + Q + + P G H+ ++
Sbjct: 904 --REVEGTRTRPGMTP----PCLSTVAPPIHQGPAVPTAVIPLPPG-------THLLFA- 949
Query: 4161 VKNKRIEVAKLDGR-YRKWLISTDLDQPAAIAVNPKLG----LMFWTDWGKEPKIESAWM 4215
+ +IE L+G RK L PA + + +++WTD EP I A +
Sbjct: 950 -QTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDI-TEPSIGRASL 1007
Query: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAK-EAMNP 4274
+G + ++ +DLG P G+++D+L + I+W+D D IE K DGT RRV+ + + +NP
Sbjct: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRN-IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
Query: 4275 YSL--DIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
+ D LYW + + + G + LV
Sbjct: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
Score = 50.1 bits (118), Expect = 5e-05
Identities = 56/197 (28%), Positives = 75/197 (38%), Gaps = 38/197 (19%)
Query: 1251 DGHPDCL--------YGSDEHNACVPK-----TCPSSY-FHCDNGNCIHRAWLCDRDNDC 1296
+G PD L +G D + AC P TC S F D C ++ + C
Sbjct: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC 721
Query: 1297 GDMSDEKDCPTQP--FRCPSWQ-WQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSC 1353
G + C P FRC + +Q CV + V I C G + C
Sbjct: 722 GSHTI---CNNHPGTFRCECVEGYQFSDEGTCVAV-VDQRPINYCETGLHNCDIPQRAQC 777
Query: 1354 SDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC--SQHCYNMRGSF 1411
+ GG ++ C C GF + D + C+D+DEC C CYN GSF
Sbjct: 778 I-YTGGSSYTCS---------CLPGF--SGDGQACQDVDECQP-SRCHPDAFCYNTPGSF 824
Query: 1412 RCSCDTGYMLESDGRTC 1428
C C GY + DG C
Sbjct: 825 TCQCKPGY--QGDGFRC 839
Score = 40.0 bits (92), Expect = 0.054
Identities = 78/310 (25%), Positives = 105/310 (33%), Gaps = 90/310 (29%)
Query: 972 NACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC-EGDPTNEPPTEQCGLFS 1030
N C TH D + C P P Q C C G R + TC + D +E P+ CG +
Sbjct: 670 NPCYIGTH-GCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPS-VCGSHT 725
Query: 1031 FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKR- 1089
C N P + C+ V+ + SDE G C+ D+R
Sbjct: 726 I-CNNH---PGTFRCECVEG-YQFSDE-------------------GTCVAV---VDQRP 758
Query: 1090 -NDCVDGSDEHNCPTHAPASCLDT---QYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNS 1145
N C G HNC A C+ T YTC C+ G D + C
Sbjct: 759 INYCETGL--HNCDIPQRAQCIYTGGSSYTC---SCLP-----------GFSGDGQACQD 802
Query: 1146 TETCQPSQFNCPNHRCIDLSFVCDGDKDCVD--GSDEVGCVLNCTASQFKCASGDKCIGV 1203
+ CQPS+ C D C + GS C F+C G+
Sbjct: 803 VDECQPSR--------------CHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEV---E 845
Query: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH----PDCLYG 1259
RC + + A P RP G+ +P ECD H P +G
Sbjct: 846 KTRCQHEREHILGAAGATDPQRP-----------IPPGLFVP---ECDAHGHYAPTQCHG 891
Query: 1260 SDEHNACVPK 1269
S + CV +
Sbjct: 892 STGYCWCVDR 901
Score = 39.3 bits (90), Expect = 0.092
Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 3/113 (2%)
Query: 2191 MPRHIVVDPKNRYLFWADYG--QRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYV 2248
+P ++ P +L +A G +R +E + + T + GLA D D V
Sbjct: 933 VPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMV 992
Query: 2249 YWVDDSLDIIARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKI 2300
YW D + I R ++ GE + +IR P + +I W D NL +I
Sbjct: 993 YWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
Score = 36.6 bits (83), Expect = 0.60
Identities = 48/190 (25%), Positives = 69/190 (36%), Gaps = 36/190 (18%)
Query: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNW-VCDGEDDCKDNGDE 253
C + CD + C+ G QFTC + C D+C E
Sbjct: 672 CYIGTHGCDTNAACRPGPRT-----------QFTCECSIGFRGDGRTCYDIDECS----E 716
Query: 254 DGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
G H + P + C C+ Y+ D C D+ + YC L +
Sbjct: 717 QPSVCGSHTICNNHPGTFRC----ECVEGYQFSDEGT-CVAVVDQRPIN---YCETGLHN 768
Query: 314 A-LNCQYQCHETPYGGA---CFCPPGYIINHNDSRTCVEFDDCQIWGIC--DQKCESRPG 367
+ + QC T GG+ C C PG+ D + C + D+CQ C D C + PG
Sbjct: 769 CDIPQRAQCIYT--GGSSYTCSCLPGF---SGDGQACQDVDECQP-SRCHPDAFCYNTPG 822
Query: 368 RHLCHCEEGY 377
C C+ GY
Sbjct: 823 SFTCQCKPGY 832
Score = 36.6 bits (83), Expect = 0.60
Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 8/46 (17%)
Query: 1331 VCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCP 1376
+ + CP G N CS NGGCTH C+ P C CP
Sbjct: 1198 ITTALSQCPQGH--------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 148 bits (373), Expect = 1e-34
Identities = 77/188 (40%), Positives = 99/188 (52%), Gaps = 20/188 (10%)
Query: 3781 YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA 3840
Y D G ++ + P F C +G C+ EL+CDG ADC D SDE +C
Sbjct: 435 YTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS------- 487
Query: 3841 YCQAT-MFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNR-FRCDNNRCIY 3898
C A F CKN C P +W CD +DCGD SDE+ C+ P + FRC N +C+
Sbjct: 488 -CDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQ-------GCSCPAQTFRCSNGKCLS 539
Query: 3899 SHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDN-VCDDADDCGDWS 3957
+ CNG DDCGDG+DE C K CT++ Y+C NG C+ N CD +DC D S
Sbjct: 540 KSQQCNGKDDCGDGSDEAS--CPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGS 597
Query: 3958 DELGCNKG 3965
DE C+ G
Sbjct: 598 DEKDCDCG 605
Score = 139 bits (350), Expect = 7e-32
Identities = 76/171 (44%), Positives = 98/171 (57%), Gaps = 17/171 (9%)
Query: 3628 SHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCK 3687
S+ +S C PGQF C GRCI + +CD DC DHSDE C CD +F+CK
Sbjct: 446 SYDSSDPC-PGQFTCRTGRCIRKELRCDGWADCTDHSDEL--NCS-----CDAGHQFTCK 497
Query: 3688 TNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGD 3747
+ C P + VC+ V+DC DNSDEQGC +C P FRC N C+ QC+G++DCGD
Sbjct: 498 NKF-CKPLFWVCDSVNDCGDNSDEQGC---SC-PAQTFRCSNGKCLSKSQQCNGKDDCGD 552
Query: 3748 NSDEENCAPRE---CTESEFRCVNQQCIPS-RWICDHYNDCGDNSDERDCE 3794
SDE +C CT+ +RC+N C+ CD DC D SDE+DC+
Sbjct: 553 GSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 136 bits (343), Expect = 4e-31
Identities = 68/154 (44%), Positives = 86/154 (55%), Gaps = 11/154 (7%)
Query: 3683 EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQ 3742
+F+C+T RCI K C+G DC D+SDE C +C F CKN C PL W CD
Sbjct: 456 QFTCRTG-RCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 3743 NDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC---EMRTCH 3799
NDCGDNSDE+ C+ C FRC N +C+ C+ +DCGD SDE C + TC
Sbjct: 512 NDCGDNSDEQGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 3800 PEYFQCTSGHCV-HSELKCDGSADCLDASDEADC 3832
++C +G C+ +CDG DC D SDE DC
Sbjct: 569 KHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 134 bits (336), Expect = 3e-30
Identities = 65/154 (42%), Positives = 88/154 (57%), Gaps = 10/154 (6%)
Query: 3723 GDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTES-EFRCVNQQCIPSRWICDHY 3781
G F C+ CI +CDG DC D+SDE NC+ C +F C N+ C P W+CD
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 3782 NDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAY 3841
NDCGDNSDE+ C +C + F+C++G C+ +C+G DC D SDEA CP +
Sbjct: 512 NDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPK--VNVVT 566
Query: 3842 CQATMFECKNHVCIPP-YWKCDGDDDCGDGSDEE 3874
C + C N +C+ +CDG +DC DGSDE+
Sbjct: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK 600
Score = 132 bits (333), Expect = 6e-30
Identities = 70/156 (44%), Positives = 82/156 (52%), Gaps = 15/156 (9%)
Query: 1072 FTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTD 1131
FTC G CI RCD DC D SDE NC A Q+TC N C WVCD+
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA-----GHQFTCKNKFCKPLFWVCDSV 511
Query: 1132 NDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC----VLNC 1187
NDCGD SDE+ C+ C F C N +C+ S C+G DC DGSDE C V+ C
Sbjct: 512 NDCGDNSDEQGCS----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 1188 TASQFKCASGDKCIGVTN-RCDGVFDCSDNSDEAGC 1222
T ++C +G C+ N CDG DCSD SDE C
Sbjct: 568 TKHTYRCLNG-LCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 126 bits (317), Expect = 4e-28
Identities = 66/157 (42%), Positives = 83/157 (52%), Gaps = 15/157 (9%)
Query: 1031 FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSS-AFTCGHGECIPAHWRCDKR 1089
F C+ GRC+ CDG DC D+SDE LN +C + FTC + C P W CD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDE-----LNCSCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 1090 NDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTE-- 1147
NDC D SDE C SC + C N +C+SK+ C+ +DCGDGSDE +C
Sbjct: 512 NDCGDNSDEQGC------SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 1148 TCQPSQFNCPNHRCIDL-SFVCDGDKDCVDGSDEVGC 1183
TC + C N C+ + CDG +DC DGSDE C
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 126 bits (316), Expect = 6e-28
Identities = 79/243 (32%), Positives = 118/243 (48%), Gaps = 34/243 (13%)
Query: 3481 LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCD-GQKDCS 3539
L++PG TC P D+ ++++G YC +QF+ +N I + + D D
Sbjct: 387 LLEPGVPAGTC--PKDY--VEINGEKYCG---ERSQFVVTSNSNKITVRFHSDQSYTDTG 439
Query: 3540 DGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEW 3599
++ L+ C GQF C G C + C+ +C D SDE C+ H ++
Sbjct: 440 FLAEYLSYDSSDPCP-GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH----QF 494
Query: 3600 QCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDND 3659
C NK C P W CD+ NDC DNSDE C ++T FRC+NG+C+ ++ +C+ +D
Sbjct: 495 TCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQT-----FRCSNGKCLSKSQQCNGKDD 549
Query: 3660 CGDHSDEPIEECMSSAHLCDNFTEFSC-KTNYRCIPKWAV------CNGVDDCRDNSDEQ 3712
CGD SDE C +C K YRC+ + C+G +DC D SDE+
Sbjct: 550 CGDGSDEA---------SCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK 600
Query: 3713 GCE 3715
C+
Sbjct: 601 DCD 603
Score = 126 bits (316), Expect = 6e-28
Identities = 62/152 (40%), Positives = 82/152 (53%), Gaps = 6/152 (3%)
Query: 112 QITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCR 171
Q TC G+CI E RCD DC D +DE +C Q TC N C CD DC
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCG 515
Query: 172 DSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC---NYPTCGGYQFT 228
D+SDE C+ C F C NG+C+ ++ C+ +DC DGSDE +C N TC + +
Sbjct: 516 DNSDEQGCS--CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYR 573
Query: 229 CPSGRCIYQ-NWVCDGEDDCKDNGDEDGCESG 259
C +G C+ + N CDG++DC D DE C+ G
Sbjct: 574 CLNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605
Score = 119 bits (299), Expect = 5e-26
Identities = 66/149 (44%), Positives = 83/149 (55%), Gaps = 12/149 (8%)
Query: 2964 RCIPQSWVCDGDVDCTDGYDENQNCTRRTCSE-NEFTCGYGLCIPKIFRCDRHNDCGDYS 3022
RCI + CDG DCTD DE NC+ C ++FTC C P + CD NDCGD S
Sbjct: 463 RCIRKELRCDGWADCTDHSDE-LNCS---CDAGHQFTCKNKFCKPLFWVCDSVNDCGDNS 518
Query: 3023 DERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEP-TCPPHEFK 3081
DE+GC +C F C NG+C+SK+ C+ +DCGDGSDE C TC H ++
Sbjct: 519 DEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEAS--CPKVNVVTCTKHTYR 573
Query: 3082 CDNGRCIEMMKL-CNHLDDCLDNSDEKGC 3109
C NG C+ C+ +DC D SDEK C
Sbjct: 574 CLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 119 bits (298), Expect = 7e-26
Identities = 67/164 (40%), Positives = 86/164 (52%), Gaps = 13/164 (7%)
Query: 70 GYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDH 129
G F C++ G+CI CD DC D SDE +CS + HQ TC N C P + CD
Sbjct: 455 GQFTCRT-GRCIRKELRCDGWADCTDHSDEL-NCSCD--AGHQFTCKNKFCKPLFWVCDS 510
Query: 130 VRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI----CLH 185
V DC D +DE C P + C NG C + SQ+C+ K DC D SDE +C ++ C
Sbjct: 511 VNDCGDNSDEQGCSCP-AQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTK 569
Query: 186 NEFSCGNGECIPRAY-VCDHDNDCQDGSDEHACNYPTCGGYQFT 228
+ + C NG C+ + CD DC DGSDE C+ CG FT
Sbjct: 570 HTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD---CGLRSFT 610
Score = 119 bits (298), Expect = 7e-26
Identities = 66/152 (43%), Positives = 83/152 (54%), Gaps = 10/152 (6%)
Query: 1113 QYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPS-QFNCPNHRCIDLSFVCDGD 1171
Q+TC +CI K CD DC D SDE NC +C QF C N C L +VCD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNC----SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 1172 KDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCH 1231
DC D SDE GC +C A F+C++G KC+ + +C+G DC D SDEA CP C
Sbjct: 512 NDCGDNSDEQGC--SCPAQTFRCSNG-KCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 1232 SDEFQCQEDGICI-PNFWECDGHPDCLYGSDE 1262
++C +G+C+ ECDG DC GSDE
Sbjct: 569 KHTYRCL-NGLCLSKGNPECDGKEDCSDGSDE 599
Score = 119 bits (298), Expect = 7e-26
Identities = 65/154 (42%), Positives = 86/154 (55%), Gaps = 15/154 (9%)
Query: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGY-FKCQSEGQCIPNSWVCDQDQ 91
F C +G CI + RCDG DC+D +DE+ C +C G+ F C+++ C P WVCD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNK-FCKPLFWVCDSVN 512
Query: 92 DCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC---QYPTCE 148
DC D SDE Q CS C + CSNG+C+ +C+ DC DG+DE C TC
Sbjct: 513 DCGDNSDE-QGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 149 QLT--CDNGACYNT-SQKCDWKVDCRDSSDEINC 179
+ T C NG C + + +CD K DC D SDE +C
Sbjct: 569 KHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 117 bits (294), Expect = 2e-25
Identities = 77/216 (35%), Positives = 107/216 (49%), Gaps = 26/216 (12%)
Query: 2696 NGER-CGASS--FTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGR 2752
NGE+ CG S SN I+ + D E S + C P FTC GR
Sbjct: 405 NGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPC-PGQFTCRTGR 463
Query: 2753 CVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTS 2812
C++ RCD + DC D SDE C C+A +F C N+ C P ++C+ V++C DN S
Sbjct: 464 CIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDSVNDCGDN--S 518
Query: 2813 DEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE------NPTYCTTHTCSS 2866
DE+ C +C + +C N C+ + C+G +DCGD SDE N CT HT
Sbjct: 519 DEQGC---SCPAQTFRCSNGK-CLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHT--- 571
Query: 2867 SEFQCASGRCIPQ-HWYCDQETDCFDASDE-PASCG 2900
++C +G C+ + + CD + DC D SDE CG
Sbjct: 572 --YRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605
Score = 115 bits (288), Expect = 1e-24
Identities = 59/146 (40%), Positives = 79/146 (54%), Gaps = 11/146 (7%)
Query: 1005 RLASNHLTCEG--DPTNEPPTEQCGL---FSFPCKNGRCVPNYYLCDGVDDCHDNSDEQL 1059
R L C+G D T+ C F CKN C P +++CD V+DC DNSDEQ
Sbjct: 463 RCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQG 522
Query: 1060 CGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH 1119
C +C + F C +G+C+ +C+ ++DC DGSDE +CP +C Y C N
Sbjct: 523 C-----SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNG 577
Query: 1120 QCISK-NWVCDTDNDCGDGSDEKNCN 1144
C+SK N CD DC DGSDEK+C+
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 112 bits (281), Expect = 7e-24
Identities = 62/165 (37%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 141 DCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAY 200
D P Q TC G C +CD DC D SDE+NC+ H +F+C N C P +
Sbjct: 448 DSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH-QFTCKNKFCKPLFW 506
Query: 201 VCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
VCD NDC D SDE C +C F C +G+C+ ++ C+G+DDC D DE C
Sbjct: 507 VCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPK-- 561
Query: 261 HDVHKCSPREWSCPESGRCISI-YKVCDGILDCPGREDENNTSTG 304
+V C+ + C +G C+S CDG DC DE + G
Sbjct: 562 VNVVTCTKHTYRC-LNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605
Score = 111 bits (278), Expect = 1e-23
Identities = 72/179 (40%), Positives = 90/179 (50%), Gaps = 19/179 (10%)
Query: 1133 DCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTAS-Q 1191
D G ++ + +S++ C P QF C RCI CDG DC D SDE+ C +C A Q
Sbjct: 437 DTGFLAEYLSYDSSDPC-PGQFTCRTGRCIRKELRCDGWADCTDHSDELNC--SCDAGHQ 493
Query: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECD 1251
F C C + CD V DC DNSDE GC C + F+C +G C+ +C+
Sbjct: 494 FTC-KNKFCKPLFWVCDSVNDCGDNSDEQGC------SCPAQTFRC-SNGKCLSKSQQCN 545
Query: 1252 GHPDCLYGSDEHNACVPK----TCPSSYFHCDNGNCIHRA-WLCDRDNDCGDMSDEKDC 1305
G DC GSDE A PK TC + C NG C+ + CD DC D SDEKDC
Sbjct: 546 GKDDCGDGSDE--ASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 110 bits (275), Expect = 3e-23
Identities = 83/234 (35%), Positives = 108/234 (46%), Gaps = 35/234 (14%)
Query: 2814 EKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCAS 2873
EK C +R S + NSN R + D G + E +Y ++ C +F C +
Sbjct: 407 EKYCGER---SQFVVTSNSNKITVRFHSDQSYTDTGFLA-EYLSYDSSDPCPG-QFTCRT 461
Query: 2874 GRCIPQHWYCDQETDCFDASDE-PASC--GHSERTCLADEFKCDGGRCIPSEWICDGDND 2930
GRCI + CD DC D SDE SC GH +F C C P W+CD ND
Sbjct: 462 GRCIRKELRCDGWADCTDHSDELNCSCDAGH--------QFTCKNKFCKPLFWVCDSVND 513
Query: 2931 CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTR 2990
CGD SDE Q +C F C N + C+ +S C+G DC DG DE +C +
Sbjct: 514 CGDNSDE------QGCSCPAQTFRCSNGK-----CLSKSQQCNGKDDCGDGSDE-ASCPK 561
Query: 2991 R---TCSENEFTCGYGLCIPKIF-RCDRHNDCGDYSDERGCLYQTCQQNQFTCQ 3040
TC+++ + C GLC+ K CD DC D SDE+ C C FT Q
Sbjct: 562 VNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC---DCGLRSFTRQ 612
Score = 109 bits (273), Expect = 6e-23
Identities = 57/154 (37%), Positives = 81/154 (52%), Gaps = 11/154 (7%)
Query: 2785 EFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDG 2844
+F C RCI +E C+G +C D+ SDE NC +C +G+ + C P ++CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDH--SDELNC---SCDAGHQFTCKNKFCKPLFWVCDS 510
Query: 2845 DNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSER 2904
NDCGDNSDE C T F+C++G+C+ + C+ + DC D SDE + +
Sbjct: 511 VNDCGDNSDEQGCSCPAQT-----FRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 2905 TCLADEFKCDGGRCI-PSEWICDGDNDCGDMSDE 2937
TC ++C G C+ CDG DC D SDE
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 109 bits (273), Expect = 6e-23
Identities = 67/161 (41%), Positives = 79/161 (49%), Gaps = 24/161 (14%)
Query: 2910 EFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCS---DSEFLCVNDRPPDRRCI 2966
+F C GRCI E CDG DC D SDE NCS +F C N + C
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDE--------LNCSCDAGHQFTCKN-----KFCK 502
Query: 2967 PQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERG 3026
P WVCD DC D DE Q C+ C F C G C+ K +C+ +DCGD SDE
Sbjct: 503 PLFWVCDSVNDCGDNSDE-QGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEAS 558
Query: 3027 C---LYQTCQQNQFTCQNGRCISK-TFVCDEDNDCGDGSDE 3063
C TC ++ + C NG C+SK CD DC DGSDE
Sbjct: 559 CPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 106 bits (264), Expect = 6e-22
Identities = 59/156 (37%), Positives = 81/156 (51%), Gaps = 14/156 (8%)
Query: 1191 QFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWEC 1250
QF C +G +CI RCDG DC+D+SDE C +F C+ C P FW C
Sbjct: 456 QFTCRTG-RCIRKELRCDGWADCTDHSDELNCSCDA-----GHQFTCKNK-FCKPLFWVC 508
Query: 1251 DGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP-TQP 1309
D DC SDE +CP+ F C NG C+ ++ C+ +DCGD SDE CP
Sbjct: 509 DSVNDCGDNSDEQGC----SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNV 564
Query: 1310 FRCPSWQWQCLGHNICVNL-SVVCDGIFDCPNGTDE 1344
C ++CL + +C++ + CDG DC +G+DE
Sbjct: 565 VTCTKHTYRCL-NGLCLSKGNPECDGKEDCSDGSDE 599
Score = 104 bits (259), Expect = 2e-21
Identities = 55/129 (42%), Positives = 67/129 (51%), Gaps = 17/129 (13%)
Query: 2982 YDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQ-NQFTCQ 3040
YD + C +FTC G CI K RCD DC D+SDE C +C +QFTC+
Sbjct: 447 YDSSDPCP------GQFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCK 497
Query: 3041 NGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDC 3100
N C +VCD NDCGD SDE +CP F+C NG+C+ + CN DDC
Sbjct: 498 NKFCKPLFWVCDSVNDCGDNSDE-------QGCSCPAQTFRCSNGKCLSKSQQCNGKDDC 550
Query: 3101 LDNSDEKGC 3109
D SDE C
Sbjct: 551 GDGSDEASC 559
Score = 93.2 bits (230), Expect = 5e-18
Identities = 57/159 (35%), Positives = 81/159 (50%), Gaps = 13/159 (8%)
Query: 3516 QFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG-QFQCSDGNCTSPQTLCNA 3574
QF C +CI +CDG DC+D SDEL C G QF C + C +C++
Sbjct: 456 QFTCRTG-RCIRKELRCDGWADCTDHSDELNCS----CDAGHQFTCKNKFCKPLFWVCDS 510
Query: 3575 HQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASR- 3633
+C D SDE + C + ++C+N +C+ +S QC+ +DC D SDE S +
Sbjct: 511 VNDCGDNSDE-----QGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 3634 TCRPGQFRCANGRCIPQAW-KCDVDNDCGDHSDEPIEEC 3671
TC +RC NG C+ + +CD DC D SDE +C
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 90.5 bits (223), Expect = 3e-17
Identities = 47/127 (37%), Positives = 63/127 (49%), Gaps = 13/127 (10%)
Query: 3847 FECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGV 3906
F C+ CI +CDG DC D SDE L+ C++ ++F C N C VC+ V
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDE-----LNCSCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 3907 DDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGK 3966
+DCGD +DE C T ++C NG C+ C+ DDCGD SDE C K
Sbjct: 512 NDCGDNSDEQGCSCPAQT--------FRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563
Query: 3967 ERTCAEN 3973
TC ++
Sbjct: 564 VVTCTKH 570
Score = 83.6 bits (205), Expect = 4e-15
Identities = 45/121 (37%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 3516 QFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAH 3575
QF C N+ C P++W CD DC D SDE C F+CS+G C S CN
Sbjct: 493 QFTC-KNKFCKPLFWVCDSVNDCGDNSDEQGCS----CPAQTFRCSNGKCLSKSQQCNGK 547
Query: 3576 QNCPDGSDEDRLLCENH-HCDSNEWQCANKRCIPE-SWQCDTFNDCEDNSDEDSSHCASR 3633
+C DGSDE N C + ++C N C+ + + +CD DC D SDE C R
Sbjct: 548 DDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLR 607
Query: 3634 T 3634
+
Sbjct: 608 S 608
Score = 79.3 bits (194), Expect = 8e-14
Identities = 57/176 (32%), Positives = 82/176 (46%), Gaps = 34/176 (19%)
Query: 1234 EFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSY-FHCDNGNCIHRAWLCDR 1292
+F C+ G CI CDG DC SDE N +C + + F C N C W+CD
Sbjct: 456 QFTCRT-GRCIRKELRCDGWADCTDHSDELNC----SCDAGHQFTCKNKFCKPLFWVCDS 510
Query: 1293 DNDCGDMSDEK--DCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDES--PLC 1348
NDCGD SDE+ CP Q FRC + + C++ S C+G DC +G+DE+ P
Sbjct: 511 VNDCGDNSDEQGCSCPAQTFRCSNGK--------CLSKSQQCNGKDDCGDGSDEASCPKV 562
Query: 1349 NGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHC 1404
N +C+ T+ C+ G L+ + C+ ++C GS + C
Sbjct: 563 NVVTCTKH----TYRCLN-----------GLCLSKGNPECDGKEDCSD-GSDEKDC 602
Score = 75.9 bits (185), Expect = 9e-13
Identities = 37/88 (42%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 2695 DNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEME-SVCALHTCSPTAFTCANGRC 2753
+ G C A +F CSNG+C+S+ +C+ +DCGDGSDE + TC+ + C NG C
Sbjct: 520 EQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLC 579
Query: 2754 V-QYSYRCDYYNDCGDGSDEAGCLFRDC 2780
+ + + CD DC DGSDE C DC
Sbjct: 580 LSKGNPECDGKEDCSDGSDEKDC---DC 604
Score = 65.9 bits (159), Expect = 9e-10
Identities = 33/83 (39%), Positives = 47/83 (56%), Gaps = 6/83 (7%)
Query: 25 GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA---VVTCQQGYFKCQSEGQCI 81
G C + FRC +G C+ +C+G DC D +DE C VVTC + ++C + G C+
Sbjct: 522 GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLN-GLCL 580
Query: 82 -PNSWVCDQDQDCDDGSDERQDC 103
+ CD +DC DGSDE+ DC
Sbjct: 581 SKGNPECDGKEDCSDGSDEK-DC 602
Score = 43.9 bits (102), Expect = 0.004
Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 2646 NQKQQCNNPCEQF---NGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGA 2702
+ +Q C+ P + F NG C QC + + ++ C N C
Sbjct: 518 SDEQGCSCPAQTFRCSNGKCL--------SKSQQCNGKDDCGDGSDEASCPKVNVVTCTK 569
Query: 2703 SSFTCSNGRCISE-EWKCDNDNDCGDGSDEMESVCALHT 2740
++ C NG C+S+ +CD DC DGSDE + C L +
Sbjct: 570 HTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/158 (26%), Positives = 60/158 (37%), Gaps = 26/158 (16%)
Query: 3918 EHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL--GCNKGKERTCAENIC 3975
E+ + PC ++ C G CI + CD DC D SDEL C+ G + TC C
Sbjct: 443 EYLSYDSSDPCPG-QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFC 501
Query: 3976 EQ---NCTQLNEGGFI-----CSCTAGFETNVFDRTSCL----------DINECEQFGTC 4017
+ C +N+ G CSC A +T CL D + +C
Sbjct: 502 KPLFWVCDSVNDCGDNSDEQGCSCPA--QTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Query: 4018 PQHCRNTKGSYECVCADGFTSMSDRP---GKRCAAEGS 4052
P+ T + C +G P GK ++GS
Sbjct: 560 PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGS 597
Score = 43.5 bits (101), Expect = 0.005
Identities = 29/97 (29%), Positives = 38/97 (39%), Gaps = 17/97 (17%)
Query: 3077 PHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHD---------PSISGCD--HN 3125
P +F C GRCI C+ DC D+SDE C + H P CD ++
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVND 513
Query: 3126 CTDTLTSFYCSCR------PGYKLMSDKRTCVDIDEC 3156
C D CSC K +S + C D+C
Sbjct: 514 CGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDC 550
Score = 33.5 bits (75), Expect = 5.1
Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 6/49 (12%)
Query: 1026 CGLFSFPCKNGRCVPNYYL-CDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
C ++ C NG C+ CDG +DC D SDE+ C C +FT
Sbjct: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC-----DCGLRSFT 610
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 144 bits (362), Expect = 3e-33
Identities = 75/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)
Query: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
+E +YW D + I R +L+ + +T+IN ++ + +AV+WV+R LYW + + V
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
+ LN ++L +D PR +ALHP+ G YW DWG I R +D
Sbjct: 61 TCLNSTSHKILVSEDMD--------EPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
Query: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
V+++ L WPNG+ +D LYW DA IE ++ R T+ LPH F T+
Sbjct: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
Query: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGC 3476
D IYWT W ++++ +K +NR +++ + + + + +NP NGG
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVN-VDKVVGTNPHADRNGGA 230
Query: 3477 SHLCLIKPGGKG 3488
+ +P G
Sbjct: 231 ATCASSRPTQPG 242
Score = 132 bits (331), Expect = 1e-29
Identities = 67/187 (35%), Positives = 109/187 (58%), Gaps = 10/187 (5%)
Query: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173
AI+RAY+ SG L+ + PD IAV+WV R +YW+ + IEV L+
Sbjct: 14 AIRRAYLDG--SGAQTLINTK------INDPDDIAVNWVARSLYWTHTGTEHIEVTCLNS 65
Query: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233
K L+S D+D+P AIA++P++GL +W DWG+ P+I+ A ++ ++ +LV LGWP G
Sbjct: 66 TSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNG 125
Query: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292
L++D L ++YW D K D IE I D T R+ + K+ + + + + D +YW + +
Sbjct: 126 LALD-LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 4293 EVWKQNK 4299
+ + +K
Sbjct: 185 SIKRVHK 191
Score = 122 bits (307), Expect = 6e-27
Identities = 70/239 (29%), Positives = 128/239 (53%), Gaps = 15/239 (6%)
Query: 755 IFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLA 814
++++D I + +DG+G + L ++ + + +A +W++++LYWT + + I V L
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 815 DKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPN 873
+ + +V + ++ PR++ +HP G ++ DW +I RA D L ++N +LGWPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 874 GLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRL 933
GLA+D +LYW DA DKIE + D R+ L +++ H F + G+ +++T W+
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTLLGDFIYWTAWQH 183
Query: 934 GAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSN------------ACNQPTHP 980
+I RV K VI + ++ LK+ +V+ G+N A ++PT P
Sbjct: 184 HSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQP 241
Score = 120 bits (301), Expect = 3e-26
Identities = 66/221 (29%), Positives = 118/221 (53%), Gaps = 5/221 (2%)
Query: 1476 ISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEV 1535
+ G ++W+D A+ +G+ + + ++ I + IA++WV R+LYWT E IEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
+ ++ + +L+S+++ PR +AL P M L +W DWG +P I+RA++D V+V
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMG--LTYWIDWGENPEIKRANLDRQELRVLVNA 118
Query: 1596 KIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655
+ WP GL +D LY+ D+ D ++ + +RQ + D + H + TL D +
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDK-LPHIFRFTLLGDFI 176
Query: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
YWT + R +K N+ V++ + +G+ AV+ K
Sbjct: 177 YWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNVDK 216
Score = 120 bits (300), Expect = 4e-26
Identities = 68/243 (27%), Positives = 123/243 (50%), Gaps = 8/243 (3%)
Query: 438 VFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLD 497
V+WTD + ++G Q ++N + P+++AV+WV +Y T I++ L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 498 GSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLG 557
+ L++E++ PR IA+ P +G ++ DW P+++RA +D + LV LG
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDW---GENPEIKRANLDRQELRVLVNASLG 121
Query: 558 WPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFT 617
WP G+ LD+ ++YW D++ D IE ++ D +R+T++ +PH F +L +++T
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWT 179
Query: 618 DWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLS 677
W ++ + +K + N V G+ ++ + TNP D NGG C S
Sbjct: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAV-NVDKVVGTNPHADRNGGA-ATCASS 236
Query: 678 HRT 680
T
Sbjct: 237 RPT 239
Score = 101 bits (251), Expect = 2e-20
Identities = 66/220 (30%), Positives = 104/220 (47%), Gaps = 6/220 (2%)
Query: 2454 GIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRA 2511
G T+I + I D IA +W+ R +Y++ + I + ++ ++ + +PRA
Sbjct: 22 GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRA 81
Query: 2512 IVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDAS 2571
I L P G YW DW + +I+RA L +VN+SL P+GL LD +E LYW DA
Sbjct: 82 IALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAK 141
Query: 2572 LQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMT 2630
+IE ++ R+ ++ + H F TL G +IYWT I R +K + + +
Sbjct: 142 TDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVII- 200
Query: 2631 TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGP 2670
+ L G+ V K NP NGG + + P
Sbjct: 201 -DQLPDLMGLK-AVNVDKVVGTNPHADRNGGAATCASSRP 238
Score = 99.4 bits (246), Expect = 8e-20
Identities = 79/263 (30%), Positives = 119/263 (45%), Gaps = 22/263 (8%)
Query: 2107 GFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFV 2166
G +YW D AIRR DGS ++ I N IAV+WVA +LY+T+
Sbjct: 3 GHVYWTDDEVW-----AIRRAYLDGSGAQTLINTKI--NDPDDIAVNWVARSLYWTHTGT 55
Query: 2167 SETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRT 2226
IEV +N+T ++L+ +D PR I + P+ +W D+G+ P+I+R+ LD
Sbjct: 56 EH--IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELR 113
Query: 2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVF 2286
VLV+ + P GLA+D +G +YW D D I I ++ E + P + T+
Sbjct: 114 VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDKLPHIFRFTLL 172
Query: 2287 ENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPC 2346
+ I W I + K N + ++ L+ V + DK V NP
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNV-DK--------VVGTNPH 223
Query: 2347 LENNGG---CSHLCFALPGLHTP 2366
+ NGG C+ PGL P
Sbjct: 224 ADRNGGAATCASSRPTQPGLAAP 246
Score = 94.7 bits (234), Expect = 2e-18
Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 15/222 (6%)
Query: 1789 EQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEV 1847
E ++YW ++ I R DG+ + + P ++A++W++R+LY T+ T+ IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPD-DIAVNWVARSLYWTHTGTEHIEV 60
Query: 1848 LTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDG 1907
L+ K L++ D + P I + P G YW D G + +I AN+D
Sbjct: 61 TCLNSTSH--KILVSED-----MDEPRAIALHPEMGLTYWIDWGENP----EIKRANLDR 109
Query: 1908 TSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRM-ILVHQLSHPWGI 1966
++ L +L + LD++E KLYW IE +VD T R +L +L H +
Sbjct: 110 QELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRF 169
Query: 1967 AVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQ 2008
+ F+Y+T Q+ I+RV K AN+ V+ D +P+L GL+
Sbjct: 170 TLLGDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLK 210
Score = 40.8 bits (94), Expect = 0.032
Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 4/95 (4%)
Query: 2518 QGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIER 2577
+G++YW D + A I RA L G+ ++N+ + P + +++ LYW + IE
Sbjct: 2 EGHVYWTDDEVWA-IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 2578 STLTGVDREVIVNAAV---HAFGLTLYGQYIYWTD 2609
+ L +++V+ + A L YW D
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWID 95
Score = 33.5 bits (75), Expect = 5.1
Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLP 3270
G N +ALD E +LYW D + IE + +++T ++T++ +LP
Sbjct: 121 GWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP 164
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 144 bits (362), Expect = 3e-33
Identities = 75/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)
Query: 3237 VEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFV 3296
+E +YW D + I R +L+ + +T+IN ++ + +AV+WV+R LYW + + V
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 3297 SDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK 3356
+ LN ++L +D PR +ALHP+ G YW DWG I R +D
Sbjct: 61 TCLNSTSHKILVSEDMD--------EPRAIALHPEMGLTYWIDWGENPEIKRANLDRQEL 112
Query: 3357 SVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIF 3416
V+++ L WPNG+ +D LYW DA IE ++ R T+ LPH F T+
Sbjct: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
Query: 3417 EDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGC 3476
D IYWT W ++++ +K +NR +++ + + + + +NP NGG
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVN-VDKVVGTNPHADRNGGA 230
Query: 3477 SHLCLIKPGGKG 3488
+ +P G
Sbjct: 231 ATCASSRPTQPG 242
Score = 132 bits (331), Expect = 1e-29
Identities = 67/187 (35%), Positives = 109/187 (58%), Gaps = 10/187 (5%)
Query: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173
AI+RAY+ SG L+ + PD IAV+WV R +YW+ + IEV L+
Sbjct: 14 AIRRAYLDG--SGAQTLINTK------INDPDDIAVNWVARSLYWTHTGTEHIEVTCLNS 65
Query: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233
K L+S D+D+P AIA++P++GL +W DWG+ P+I+ A ++ ++ +LV LGWP G
Sbjct: 66 TSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNG 125
Query: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292
L++D L ++YW D K D IE I D T R+ + K+ + + + + D +YW + +
Sbjct: 126 LALD-LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHH 184
Query: 4293 EVWKQNK 4299
+ + +K
Sbjct: 185 SIKRVHK 191
Score = 122 bits (307), Expect = 6e-27
Identities = 70/239 (29%), Positives = 128/239 (53%), Gaps = 15/239 (6%)
Query: 755 IFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLA 814
++++D I + +DG+G + L ++ + + +A +W++++LYWT + + I V L
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 815 DKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPN 873
+ + +V + ++ PR++ +HP G ++ DW +I RA D L ++N +LGWPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 874 GLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRL 933
GLA+D +LYW DA DKIE + D R+ L +++ H F + G+ +++T W+
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTLLGDFIYWTAWQH 183
Query: 934 GAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSN------------ACNQPTHP 980
+I RV K VI + ++ LK+ +V+ G+N A ++PT P
Sbjct: 184 HSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQP 241
Score = 120 bits (301), Expect = 3e-26
Identities = 66/221 (29%), Positives = 118/221 (53%), Gaps = 5/221 (2%)
Query: 1476 ISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEV 1535
+ G ++W+D A+ +G+ + + ++ I + IA++WV R+LYWT E IEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1536 SKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQD 1595
+ ++ + +L+S+++ PR +AL P M L +W DWG +P I+RA++D V+V
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMG--LTYWIDWGENPEIKRANLDRQELRVLVNA 118
Query: 1596 KIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655
+ WP GL +D LY+ D+ D ++ + +RQ + D + H + TL D +
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDK-LPHIFRFTLLGDFI 176
Query: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSK 1696
YWT + R +K N+ V++ + +G+ AV+ K
Sbjct: 177 YWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNVDK 216
Score = 120 bits (300), Expect = 4e-26
Identities = 68/243 (27%), Positives = 123/243 (50%), Gaps = 8/243 (3%)
Query: 438 VFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLD 497
V+WTD + ++G Q ++N + P+++AV+WV +Y T I++ L+
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 498 GSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLG 557
+ L++E++ PR IA+ P +G ++ DW P+++RA +D + LV LG
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDW---GENPEIKRANLDRQELRVLVNASLG 121
Query: 558 WPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFT 617
WP G+ LD+ ++YW D++ D IE ++ D +R+T++ +PH F +L +++T
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWT 179
Query: 618 DWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLS 677
W ++ + +K + N V G+ ++ + TNP D NGG C S
Sbjct: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAV-NVDKVVGTNPHADRNGGA-ATCASS 236
Query: 678 HRT 680
T
Sbjct: 237 RPT 239
Score = 101 bits (251), Expect = 2e-20
Identities = 66/220 (30%), Positives = 104/220 (47%), Gaps = 6/220 (2%)
Query: 2454 GIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRA 2511
G T+I + I D IA +W+ R +Y++ + I + ++ ++ + +PRA
Sbjct: 22 GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRA 81
Query: 2512 IVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDAS 2571
I L P G YW DW + +I+RA L +VN+SL P+GL LD +E LYW DA
Sbjct: 82 IALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAK 141
Query: 2572 LQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMT 2630
+IE ++ R+ ++ + H F TL G +IYWT I R +K + + +
Sbjct: 142 TDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVII- 200
Query: 2631 TNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGP 2670
+ L G+ V K NP NGG + + P
Sbjct: 201 -DQLPDLMGLK-AVNVDKVVGTNPHADRNGGAATCASSRP 238
Score = 99.4 bits (246), Expect = 8e-20
Identities = 79/263 (30%), Positives = 119/263 (45%), Gaps = 22/263 (8%)
Query: 2107 GFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFV 2166
G +YW D AIRR DGS ++ I N IAV+WVA +LY+T+
Sbjct: 3 GHVYWTDDEVW-----AIRRAYLDGSGAQTLINTKI--NDPDDIAVNWVARSLYWTHTGT 55
Query: 2167 SETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRT 2226
IEV +N+T ++L+ +D PR I + P+ +W D+G+ P+I+R+ LD
Sbjct: 56 EH--IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELR 113
Query: 2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVF 2286
VLV+ + P GLA+D +G +YW D D I I ++ E + P + T+
Sbjct: 114 VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVD-ETKRQTLLKDKLPHIFRFTLL 172
Query: 2287 ENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPC 2346
+ I W I + K N + ++ L+ V + DK V NP
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNV-DK--------VVGTNPH 223
Query: 2347 LENNGG---CSHLCFALPGLHTP 2366
+ NGG C+ PGL P
Sbjct: 224 ADRNGGAATCASSRPTQPGLAAP 246
Score = 94.7 bits (234), Expect = 2e-18
Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 15/222 (6%)
Query: 1789 EQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEV 1847
E ++YW ++ I R DG+ + + P ++A++W++R+LY T+ T+ IEV
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPD-DIAVNWVARSLYWTHTGTEHIEV 60
Query: 1848 LTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDG 1907
L+ K L++ D + P I + P G YW D G + +I AN+D
Sbjct: 61 TCLNSTSH--KILVSED-----MDEPRAIALHPEMGLTYWIDWGENP----EIKRANLDR 109
Query: 1908 TSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRM-ILVHQLSHPWGI 1966
++ L +L + LD++E KLYW IE +VD T R +L +L H +
Sbjct: 110 QELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRF 169
Query: 1967 AVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQ 2008
+ F+Y+T Q+ I+RV K AN+ V+ D +P+L GL+
Sbjct: 170 TLLGDFIYWTAWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLK 210
Score = 40.8 bits (94), Expect = 0.032
Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 4/95 (4%)
Query: 2518 QGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIER 2577
+G++YW D + A I RA L G+ ++N+ + P + +++ LYW + IE
Sbjct: 2 EGHVYWTDDEVWA-IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 2578 STLTGVDREVIVNAAV---HAFGLTLYGQYIYWTD 2609
+ L +++V+ + A L YW D
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWID 95
Score = 33.5 bits (75), Expect = 5.1
Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLP 3270
G N +ALD E +LYW D + IE + +++T ++T++ +LP
Sbjct: 121 GWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP 164
>gi|167555125 low density lipoprotein receptor-related protein 3 [Homo
sapiens]
Length = 770
Score = 127 bits (319), Expect = 3e-28
Identities = 110/386 (28%), Positives = 145/386 (37%), Gaps = 69/386 (17%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANG-------- 2751
C A F C NG+C+ W+C+ ++CGDGSDE C+ P C G
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGN--CSAPASEPPGSLCPGGTFPCSGAR 223
Query: 2752 --RCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDN 2809
RC+ RCD DCGDGSDEAGC C + G + H
Sbjct: 224 STRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
Query: 2810 NTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEF 2869
D ++ Q ++ + +VY +G + GD + +Y + H S E
Sbjct: 284 WLVDTQDSRRVLLQLELRLGYDDYV---QVY--EGLGERGDRLLQTLSYRSNHRPVSLE- 337
Query: 2870 QCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDN 2929
A GR T + A S GH + G C+P E
Sbjct: 338 -AAQGRL----------TVAYHA--RARSAGHGFNATYQVK-----GYCLPWE------Q 373
Query: 2930 DCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCT 2989
CG SD D D+ C + CDG C G DE Q C
Sbjct: 374 PCGSSSDSD------------------GGSLGDQGCFSEPQRCDGWWHCASGRDE-QGCP 414
Query: 2990 RRTCSENEFTC--GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISK 3047
C +++ C G GLC RC+ C D +DE+ C +CQ F C CI +
Sbjct: 415 --ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQPGTFHCGTNLCIFE 470
Query: 3048 TFVCDEDNDCGDGSDELMHLCHTPEP 3073
T+ CD DC DGSDE H C P
Sbjct: 471 TWRCDGQEDCQDGSDE--HGCLAAVP 494
Score = 100 bits (250), Expect = 3e-20
Identities = 94/368 (25%), Positives = 135/368 (36%), Gaps = 78/368 (21%)
Query: 3550 QRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH-----CDSNEWQCA-- 3602
Q C+ +F+C +G C CN C DGSDE C + C+
Sbjct: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
Query: 3603 -NKRCIPESWQCDTFNDCEDNSDEDSSHCASRTC------------RPGQFRCANGRCIP 3649
+ RC+P +CD DC D SDE + C C P F A G P
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDE--AGCPDLACGRRLGSFYGSFASPDLFGAARG---P 277
Query: 3650 QAWKCDVDNDCGDHS------------DEPIEECMSSAHLCDNFTE-FSCKTNYRCIPKW 3696
C D D D+ ++ D + S ++N+R +
Sbjct: 278 SDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLE 337
Query: 3697 AVCNGVD---DCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEEN 3753
A + R S G ++ K + C+P W+ CG +SD +
Sbjct: 338 AAQGRLTVAYHARARSAGHGFN-------ATYQVKGY-CLP--WE----QPCGSSSDSDG 383
Query: 3754 CAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCT--SGHCV 3811
+ + Q C CD + C DE+ C C P+ + C SG C
Sbjct: 384 GSLGD----------QGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCY 431
Query: 3812 HSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGS 3871
+C+ C D +DE +C + CQ F C ++CI W+CDG +DC DGS
Sbjct: 432 TPADRCNNQKSCPDGADEKNCFS-------CQPGTFHCGTNLCIFETWRCDGQEDCQDGS 484
Query: 3872 DEELHLCL 3879
DE H CL
Sbjct: 485 DE--HGCL 490
Score = 100 bits (249), Expect = 3e-20
Identities = 97/345 (28%), Positives = 131/345 (37%), Gaps = 75/345 (21%)
Query: 2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRD-------CNATTEFMCN--- 2789
+C F C NG+C+ ++C+ ++CGDGSDE C C T F C+
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGT-FPCSGAR 223
Query: 2790 NRRCIPREFICNGVDNCHDNNTSDEKNCPDRTC-------------------QSGYTKCH 2830
+ RC+P E C+G+ +C D SDE CPD C G + H
Sbjct: 224 STRCLPVERRCDGLQDCGDG--SDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
Query: 2831 NSNICIPR------------------VYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
+ + + V + +G + GD + +Y + H S E A
Sbjct: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLE--AA 339
Query: 2873 SGR-CIPQHWYCDQETDCFDASDE-PASCGHSERTCLADEFKCDGGR-----CIPSEWIC 2925
GR + H F+A+ + C E+ C DGG C C
Sbjct: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPC-GSSSDSDGGSLGDQGCFSEPQRC 398
Query: 2926 DGDNDCGDMSDEDKRHQC--QNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
DG C DE C C LC P DR C+ C DG D
Sbjct: 399 DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYT--PADR--------CNNQKSCPDGAD 448
Query: 2984 ENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCL 3028
E +NC +C F CG LCI + +RCD DC D SDE GCL
Sbjct: 449 E-KNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
Score = 94.0 bits (232), Expect = 3e-18
Identities = 85/333 (25%), Positives = 115/333 (34%), Gaps = 66/333 (19%)
Query: 3683 EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD------FRC---KNHHCI 3733
EF C N +C+P CN VD+C D SDE C P G F C ++ C+
Sbjct: 170 EFRCD-NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCL 228
Query: 3734 PLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPS-------------RWICDH 3780
P+ +CDG DCGD SDE C C P W+ D
Sbjct: 229 PVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDT 288
Query: 3781 ----------------------YNDCGDNSDE--RDCEMRTCH-PEYFQCTSGHCV---H 3812
Y G+ D + R+ H P + G H
Sbjct: 289 QDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYH 348
Query: 3813 SELKCDGSADCLDASDEADC-PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGS 3871
+ + G + C P P G+ + + C +CDG C G
Sbjct: 349 ARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGR 408
Query: 3872 DEELHLCLDVPCNSPNRFRCDNNR--CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCT 3929
DE+ P P+++ C+ C + CN C DG DE ++C C
Sbjct: 409 DEQ-----GCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS-----CQ 456
Query: 3930 EYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
+ CG CI CD +DC D SDE GC
Sbjct: 457 PGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 91.7 bits (226), Expect = 2e-17
Identities = 83/329 (25%), Positives = 119/329 (36%), Gaps = 57/329 (17%)
Query: 1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPAS------CLDTQYTCD-- 1117
+C + F C +G+C+P W+C+ ++C DGSDE NC APAS C + C
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC--SAPASEPPGSLCPGGTFPCSGA 222
Query: 1118 -NHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKD--- 1173
+ +C+ CD DCGDGSDE C + + DL G D
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC 282
Query: 1174 --CVDGSDEVGCVLN----------CTASQFKCASGDKCIGV----TNRCDGVFDCSDNS 1217
VD D +L + GD+ + +N + +
Sbjct: 283 TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGR 342
Query: 1218 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPK-------- 1269
R H Q G C+P C D GS C +
Sbjct: 343 LTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWW 402
Query: 1270 ------------TCPSSYFHCDNGN--CIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSW 1315
CP + C+ G+ C A C+ C D +DEK+C F C
Sbjct: 403 HCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPG 458
Query: 1316 QWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
+ C G N+C+ + CDG DC +G+DE
Sbjct: 459 TFHC-GTNLCIFETWRCDGQEDCQDGSDE 486
Score = 90.1 bits (222), Expect = 5e-17
Identities = 50/130 (38%), Positives = 65/130 (50%), Gaps = 13/130 (10%)
Query: 1057 EQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC 1116
EQ CG+ +++ S G C RCD C G DE CP +C QY C
Sbjct: 372 EQPCGSSSDSDGGSL---GDQGCFSEPQRCDGWWHCASGRDEQGCP-----ACPPDQYPC 423
Query: 1117 DNHQ--CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDC 1174
+ C + C+ C DG+DEKNC S CQP F+C + CI ++ CDG +DC
Sbjct: 424 EGGSGLCYTPADRCNNQKSCPDGADEKNCFS---CQPGTFHCGTNLCIFETWRCDGQEDC 480
Query: 1175 VDGSDEVGCV 1184
DGSDE GC+
Sbjct: 481 QDGSDEHGCL 490
Score = 89.0 bits (219), Expect = 1e-16
Identities = 88/340 (25%), Positives = 116/340 (34%), Gaps = 76/340 (22%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGT-----LNNTCSSSAFTCGHG--- 1077
C F C NG+C+P + C+ VD+C D SDE C + C F C
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 1078 ECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQY----------TCDNHQCISKNWV 1127
C+P RCD DC DGSDE CP A L + Y + W+
Sbjct: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWL 285
Query: 1128 CDTDN------------------DCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCD 1169
DT + +G E+ +T NHR + L
Sbjct: 286 VDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRS----NHRPVSLE-AAQ 340
Query: 1170 GDKDCV--DGSDEVGCVLNCTAS-QFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC---P 1223
G + G N T + C ++ G ++ DG + + GC P
Sbjct: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDG-----GSLGDQGCFSEP 395
Query: 1224 TRPPGMCH----SDEFQCQEDGICIPNFWECDG--------------HPDCLYGSDEHNA 1265
R G H DE C C P+ + C+G C G+DE N
Sbjct: 396 QRCDGWWHCASGRDEQGCP---ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC 452
Query: 1266 CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
+C FHC CI W CD DC D SDE C
Sbjct: 453 F---SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 88.6 bits (218), Expect = 1e-16
Identities = 82/337 (24%), Positives = 116/337 (34%), Gaps = 102/337 (30%)
Query: 2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE-PASCGHSE---RTCLADEFKCDGG-- 2916
+C + EF+C +G+C+P W C+ +C D SDE S SE C F C G
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 2917 -RCIPSEWICDGDNDCGDMSDEDKRHQCQNQNC-----------SDSEFLCVNDRPPDRR 2964
RC+P E CDG DCGD SDE C + C + + P D
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDE---AGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
Query: 2965 CIPQSWVCDG--------DVDCTDGYDE-----------------------NQNCTRRTC 2993
C +W+ D ++ GYD+ N
Sbjct: 282 C---TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEA 338
Query: 2994 SENEFTCGY------------------GLCIPKIFRCDRHNDC-GDYSDERGCLYQ---- 3030
++ T Y G C+P C +D G ++GC +
Sbjct: 339 AQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRC 398
Query: 3031 ----------------TCQQNQFTCQ--NGRCISKTFVCDEDNDCGDGSDELMHLCHTPE 3072
C +Q+ C+ +G C + C+ C DG+DE
Sbjct: 399 DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF----- 453
Query: 3073 PTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
+C P F C CI C+ +DC D SDE GC
Sbjct: 454 -SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 87.0 bits (214), Expect = 4e-16
Identities = 89/372 (23%), Positives = 118/372 (31%), Gaps = 91/372 (24%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT-------CQQGYFKCQS--EG 78
C + FRC +G C+P W+C+ +C D +DE C+ C G F C
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTC------------SSHQITCSNGQCIPSEYR 126
+C+P CD QDC DGSDE C C S + G PS+
Sbjct: 226 RCLPVERRCDGLQDCGDGSDE-AGCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLH 281
Query: 127 CDHVRDCPDG-----------------------ADENDCQYPTCEQLTCDNGACYNTSQ- 162
C + D D + D T + +Q
Sbjct: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
Query: 163 --KCDWKVDCRDSSDEINCT----EICLHNEFSCGNGE-----------CIPRAYVCDHD 205
+ R + N T CL E CG+ C CD
Sbjct: 342 RLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGW 401
Query: 206 NDCQDGSDEHACNYPTCGGYQFTCP--SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDV 263
C G DE C P C Q+ C SG C C+ + C D DE C S
Sbjct: 402 WHCASGRDEQGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS----- 454
Query: 264 HKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTST-------------GKYCSMT 310
C P + C + CI CDG DC DE+ C +
Sbjct: 455 --CQPGTFHC-GTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLL 511
Query: 311 LCSALNCQYQCH 322
L AL C ++ +
Sbjct: 512 LVIALGCAFKLY 523
Score = 79.7 bits (195), Expect = 6e-14
Identities = 78/313 (24%), Positives = 115/313 (36%), Gaps = 58/313 (18%)
Query: 1107 ASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET------CQPSQFNCP--- 1157
ASC ++ CDN +C+ W C+T ++CGDGSDE NC++ + C F C
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
Query: 1158 NHRCIDLSFVCDGDKDCVDGSDEVGCV-LNC---TASQFKCASGDKCIGVTN-----RCD 1208
+ RC+ + CDG +DC DGSDE GC L C S + + G C
Sbjct: 224 STRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
Query: 1209 GVFDCSDNSDEAGCPTRPPGMCHSDEFQCQE------DGICIPNFWECDGHPDCLYGSDE 1262
+ D D+ + + D Q E D + + + P L +
Sbjct: 284 WLVDTQDS--RRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
Query: 1263 HNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSD-------EKDCPTQPFRCPSW 1315
S H N + + + CG SD ++ C ++P RC W
Sbjct: 342 RLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGW 401
Query: 1316 QWQCL--------------------GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSD 1355
W C G +C + C+ CP+G DE N SC
Sbjct: 402 -WHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK---NCFSCQP 457
Query: 1356 FNGGC-THECVQE 1367
C T+ C+ E
Sbjct: 458 GTFHCGTNLCIFE 470
Score = 75.1 bits (183), Expect = 2e-12
Identities = 79/314 (25%), Positives = 113/314 (35%), Gaps = 78/314 (24%)
Query: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQ-------STCSSHQITCSNG 118
+CQ F+C + G+C+P W C+ +C DGSDE +CS S C CS
Sbjct: 165 SCQADEFRCDN-GKCLPGPWQCNTVDECGDGSDEG-NCSAPASEPPGSLCPGGTFPCSGA 222
Query: 119 Q---CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN--------------TS 161
+ C+P E RCD ++DC DG+DE C C + G+ Y +
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRL---GSFYGSFASPDLFGAARGPSD 279
Query: 162 QKCDWKVDCRDSSDEINCTEICL----HNEFSCGNGECIPR-----AYVCDHDNDCQDGS 212
C W VD +DS + E+ L + + G GE R +Y +H + +
Sbjct: 280 LHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAA 339
Query: 213 D------EHACNYPTCGGYQFTCP-SGRCIYQNWVCDGEDD------------------- 246
HA G+ T G C+ C D
Sbjct: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCD 399
Query: 247 ----CKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTS 302
C DE GC + P D + C SG C + C+ CP DE N
Sbjct: 400 GWWHCASGRDEQGCPACPPDQYPCE------GGSGLCYTPADRCNNQKSCPDGADEKNCF 453
Query: 303 TGK----YCSMTLC 312
+ + +C LC
Sbjct: 454 SCQPGTFHCGTNLC 467
Score = 71.6 bits (174), Expect = 2e-11
Identities = 48/153 (31%), Positives = 61/153 (39%), Gaps = 26/153 (16%)
Query: 1077 GECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGD 1136
G C+P C +D GS + C S+ CD C
Sbjct: 366 GYCLPWEQPCGSSSDSDGGS-------------------LGDQGCFSEPQRCDGWWHCAS 406
Query: 1137 GSDEKNCNSTETCQPSQFNCPNHR--CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKC 1194
G DE+ C + C P Q+ C C + C+ K C DG+DE C +C F C
Sbjct: 407 GRDEQGCPA---CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC-FSCQPGTFHC 462
Query: 1195 ASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
+ + CI T RCDG DC D SDE GC P
Sbjct: 463 GT-NLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 70.9 bits (172), Expect = 3e-11
Identities = 34/83 (40%), Positives = 44/83 (53%), Gaps = 9/83 (10%)
Query: 3887 NRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKP----CTEYEYKCGNGH--- 3939
+ FRCDN +C+ CN VD+CGDG+DE +C P +P C + C
Sbjct: 169 DEFRCDNGKCLPGPWQCNTVDECGDGSDEG--NCSAPASEPPGSLCPGGTFPCSGARSTR 226
Query: 3940 CIPHDNVCDDADDCGDWSDELGC 3962
C+P + CD DCGD SDE GC
Sbjct: 227 CLPVERRCDGLQDCGDGSDEAGC 249
Score = 70.5 bits (171), Expect = 4e-11
Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 6/119 (5%)
Query: 25 GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQS-EGQCIPN 83
G DS G C RCDG C+ DE GC C + C+ G C
Sbjct: 376 GSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSGLCYTP 433
Query: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
+ C+ + C DG+DE+ S C C CI +RCD DC DG+DE+ C
Sbjct: 434 ADRCNNQKSCPDGADEKNCFS---CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 70.1 bits (170), Expect = 5e-11
Identities = 37/92 (40%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 3025 RGCLYQ-TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEP---TCPPHEF 3080
RG L Q +CQ ++F C NG+C+ + C+ ++CGDGSDE EP CP F
Sbjct: 158 RGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
Query: 3081 KCDNG---RCIEMMKLCNHLDDCLDNSDEKGC 3109
C RC+ + + C+ L DC D SDE GC
Sbjct: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGC 249
Score = 68.9 bits (167), Expect = 1e-10
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 2903 ERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK----RHQCQNQNCSDSEFLCVND 2958
+ +C ADEF+CD G+C+P W C+ ++CGD SDE + C F C
Sbjct: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
Query: 2959 RPPDRRCIPQSWVCDGDVDCTDGYDE 2984
R RC+P CDG DC DG DE
Sbjct: 223 R--STRCLPVERRCDGLQDCGDGSDE 246
Score = 67.8 bits (164), Expect = 2e-10
Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 7/92 (7%)
Query: 3797 TCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC--PTRFPDGAYCQATMFEC---KN 3851
+C + F+C +G C+ +C+ +C D SDE +C P P G+ C F C ++
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 3852 HVCIPPYWKCDGDDDCGDGSDEELHLCLDVPC 3883
C+P +CDG DCGDGSDE C D+ C
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEA--GCPDLAC 254
Score = 66.6 bits (161), Expect = 5e-10
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 12/95 (12%)
Query: 100 RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQ--LTCDNGA- 156
R Q++C + + C NG+C+P ++C+ V +C DG+DE +C P E C G
Sbjct: 158 RGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
Query: 157 ---------CYNTSQKCDWKVDCRDSSDEINCTEI 182
C ++CD DC D SDE C ++
Sbjct: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
Score = 65.9 bits (159), Expect = 9e-10
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 13/86 (15%)
Query: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSP-------NRFRCD 3892
A CQA F C N C+P W+C+ D+CGDGSDE P + P F C
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG---NCSAPASEPPGSLCPGGTFPCS 220
Query: 3893 ---NNRCIYSHEVCNGVDDCGDGTDE 3915
+ RC+ C+G+ DCGDG+DE
Sbjct: 221 GARSTRCLPVERRCDGLQDCGDGSDE 246
Score = 65.5 bits (158), Expect = 1e-09
Identities = 33/108 (30%), Positives = 46/108 (42%), Gaps = 6/108 (5%)
Query: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSD 3789
C +CDG C DE+ C C ++ C C C++ C D +D
Sbjct: 391 CFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
Query: 3790 ERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
E++C +C P F C + C+ +CDG DC D SDE C P
Sbjct: 449 EKNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
Score = 65.5 bits (158), Expect = 1e-09
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDNDNDCGDGSDEMESVCA 2737
+G W+ A+ R C + C G C + +C+N C DG+DE
Sbjct: 399 DGWWHCASGRDE---QGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF-- 453
Query: 2738 LHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCL 2776
+C P F C C+ ++RCD DC DGSDE GCL
Sbjct: 454 --SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
Score = 63.2 bits (152), Expect = 6e-09
Identities = 40/144 (27%), Positives = 55/144 (38%), Gaps = 27/144 (18%)
Query: 3525 CIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
C+P C D GS D C S C+ +C G DE
Sbjct: 368 CLPWEQPCGSSSDSDGGS-----------------LGDQGCFSEPQRCDGWWHCASGRDE 410
Query: 3585 DRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC 3642
C +++ C + C + +C+ C D +DE +C S C+PG F C
Sbjct: 411 QGCPA----CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS--CQPGTFHC 462
Query: 3643 ANGRCIPQAWKCDVDNDCGDHSDE 3666
CI + W+CD DC D SDE
Sbjct: 463 GTNLCIFETWRCDGQEDCQDGSDE 486
Score = 62.4 bits (150), Expect = 1e-08
Identities = 31/83 (37%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 1026 CGLFSFPCKNGR--CVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAH 1083
C +PC+ G C C+ C D +DE+ C + C F CG CI
Sbjct: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS----CQPGTFHCGTNLCIFET 471
Query: 1084 WRCDKRNDCVDGSDEHNCPTHAP 1106
WRCD + DC DGSDEH C P
Sbjct: 472 WRCDGQEDCQDGSDEHGCLAAVP 494
Score = 57.4 bits (137), Expect = 3e-07
Identities = 38/124 (30%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 111 HQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDC 170
H S+GQ +R ++R + CQ ++ CDNG C +C+ +C
Sbjct: 140 HSDASSSGQA--QGFRLSYIRG---KLGQASCQ---ADEFRCDNGKCLPGPWQCNTVDEC 191
Query: 171 RDSSDEINCT--------EICLHNEFSCGNGE---CIPRAYVCDHDNDCQDGSDEHACNY 219
D SDE NC+ +C F C C+P CD DC DGSDE C
Sbjct: 192 GDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPD 251
Query: 220 PTCG 223
CG
Sbjct: 252 LACG 255
Score = 54.7 bits (130), Expect = 2e-06
Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 10/82 (12%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE------LALCPQRFCRLGQFQCSDG-- 3563
C + +F C +N KC+P W+C+ +C DGSDE + P C G F CS
Sbjct: 166 CQADEFRC-DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 3564 -NCTSPQTLCNAHQNCPDGSDE 3584
C + C+ Q+C DGSDE
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDE 246
Score = 50.8 bits (120), Expect = 3e-05
Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 14/127 (11%)
Query: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLT 3131
+ +C EF+CDNG+C+ CN +D+C D SDE C +P S C
Sbjct: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA-PASEPPGSLCPGG------ 215
Query: 3132 SFYCSCRPGYKLMSDKRTCVDIDECTE-------MPFVCSQKCENVIGSYICKCAPGYLR 3184
+F CS + + +R C + +C + C ++ + GS+ G R
Sbjct: 216 TFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAAR 275
Query: 3185 EPDGKTC 3191
P C
Sbjct: 276 GPSDLHC 282
Score = 47.8 bits (112), Expect = 3e-04
Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 17/90 (18%)
Query: 2666 CAPGPNGAEC------QCPHEGNWYLA-------NNRKHCIVDNGER----CGASSFTCS 2708
CA G + C Q P EG L NN+K C E+ C +F C
Sbjct: 404 CASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCG 463
Query: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
CI E W+CD DC DGSDE + A+
Sbjct: 464 TNLCIFETWRCDGQEDCQDGSDEHGCLAAV 493
Score = 46.6 bits (109), Expect = 6e-04
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 8/62 (12%)
Query: 3511 MCSSTQFLC--ANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFC--RLGQFQCSDGNCT 3566
+C F C A + +C+P+ +CDG +DC DGSDE A CP C RLG F G+
Sbjct: 211 LCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDE-AGCPDLACGRRLGSFY---GSFA 266
Query: 3567 SP 3568
SP
Sbjct: 267 SP 268
Score = 45.8 bits (107), Expect = 0.001
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 1017 PTNEPPTEQCGLFSFPC---KNGRCVPNYYLCDGVDDCHDNSDEQLCGTL 1063
P +EPP C +FPC ++ RC+P CDG+ DC D SDE C L
Sbjct: 203 PASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
Score = 42.7 bits (99), Expect = 0.008
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN 3963
C E++C NG C+P C+ D+CGD SDE C+
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCS 201
Score = 37.7 bits (86), Expect = 0.27
Identities = 25/94 (26%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 968 QTGSNACNQPTHPNGDCSHFCF-PVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQC 1026
+ G AC +P S C+ P CP D +E C
Sbjct: 410 EQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCP--------------DGADEKNCFSC 455
Query: 1027 GLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
+F C C+ + CDG +DC D SDE C
Sbjct: 456 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 127 bits (318), Expect = 3e-28
Identities = 69/205 (33%), Positives = 90/205 (43%), Gaps = 49/205 (23%)
Query: 1067 CSSSAFTC-GHGECIPAHWRCDKRNDCVDGSDEHNCP----------------------- 1102
C+ + F C + EC+ +RCD+R DC D SDE NC
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 1103 ----------THAPAS----------CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKN 1142
THAP C + C N CI ++++CD DC DGSDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 1143 CNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLN-----CTASQFKCASG 1197
C C+P++F C N C + CDGD DC D +DE C C +QF+C S
Sbjct: 319 CGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVST 378
Query: 1198 DKCIGVTNRCDGVFDCSDNSDEAGC 1222
+ CI + CD DC D SDE GC
Sbjct: 379 NMCIPASFHCDEESDCPDRSDEFGC 403
Score = 120 bits (300), Expect = 4e-26
Identities = 59/145 (40%), Positives = 76/145 (52%), Gaps = 3/145 (2%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWR 1085
CG C+NG C+P YLCDG +DC D SDE CG C + F CG+G C WR
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGP-PPPCEPNEFPCGNGHCALKLWR 343
Query: 1086 CDKRNDCVDGSDEHNCPTHAPAS-CLDTQYTC-DNHQCISKNWVCDTDNDCGDGSDEKNC 1143
CD DC D +DE NCPT P C TQ+ C + CI ++ CD ++DC D SDE C
Sbjct: 344 CDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Query: 1144 NSTETCQPSQFNCPNHRCIDLSFVC 1168
+ P + + R ++F C
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTC 428
Score = 119 bits (299), Expect = 5e-26
Identities = 67/199 (33%), Positives = 87/199 (43%), Gaps = 50/199 (25%)
Query: 3724 DFRCKNHH-CIPLRWQCDGQNDCGDNSDEENCA--------------------------- 3755
+F C +++ C+ L ++CD + DC D SDE NC
Sbjct: 203 EFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTI 262
Query: 3756 -------------------PRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC-EM 3795
P C E C N CIP ++CD DC D SDE DC
Sbjct: 263 MRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPP 322
Query: 3796 RTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFEC-KNHVC 3854
C P F C +GHC +CDG DC D +DEA+CPT+ P+ C T F C ++C
Sbjct: 323 PPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPE-EVCGPTQFRCVSTNMC 381
Query: 3855 IPPYWKCDGDDDCGDGSDE 3873
IP + CD + DC D SDE
Sbjct: 382 IPASFHCDEESDCPDRSDE 400
Score = 118 bits (295), Expect = 2e-25
Identities = 71/230 (30%), Positives = 97/230 (42%), Gaps = 52/230 (22%)
Query: 1106 PASCLDTQYTCDNH-QCISKNWVCDTDNDCGDGSDEKNCNS------------TET---- 1148
P +C + ++ C ++ +C++ + CD DC D SDE NC ET
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 1149 -----------------------------CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSD 1179
C P + C N CI ++CDG +DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 1180 EVGC--VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPT-RPPGMCHSDEFQ 1236
E+ C C ++F C +G C RCDG FDC D +DEA CPT RP +C +F+
Sbjct: 316 ELDCGPPPPCEPNEFPCGNGH-CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFR 374
Query: 1237 CQEDGICIPNFWECDGHPDCLYGSDEHNACVPK--TCPSSYFHCDNGNCI 1284
C +CIP + CD DC SDE P+ T P G +
Sbjct: 375 CVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTV 424
Score = 117 bits (292), Expect = 3e-25
Identities = 68/203 (33%), Positives = 91/203 (44%), Gaps = 46/203 (22%)
Query: 1187 CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC--------------------PTRP 1226
CT ++F C S ++C+ + RCD DC D SDE C P RP
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 1227 -----------------------PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEH 1263
P C E C+ +G CIP + CDG DC GSDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-NGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 1264 NACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR--CPSWQWQCLG 1321
+ P C + F C NG+C + W CD D DC D +DE +CPT+ C Q++C+
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS 377
Query: 1322 HNICVNLSVVCDGIFDCPNGTDE 1344
N+C+ S CD DCP+ +DE
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDE 400
Score = 112 bits (280), Expect = 9e-24
Identities = 64/191 (33%), Positives = 80/191 (41%), Gaps = 51/191 (26%)
Query: 157 CYNTSQKCDWKVDCRDSSDEINCTEI---------------------------------- 182
C +CD + DCRD SDE+NC E
Sbjct: 212 CVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHA 271
Query: 183 -------------CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACN-YPTCGGYQFT 228
C E +C NG CIPR Y+CD DC+DGSDE C P C +F
Sbjct: 272 PQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFP 331
Query: 229 CPSGRCIYQNWVCDGEDDCKDNGDEDGCES-GPHDVHKCSPREWSCPESGRCISIYKVCD 287
C +G C + W CDG+ DC+D DE C + P +V C P ++ C + CI CD
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEV--CGPTQFRCVSTNMCIPASFHCD 389
Query: 288 GILDCPGREDE 298
DCP R DE
Sbjct: 390 EESDCPDRSDE 400
Score = 111 bits (278), Expect = 1e-23
Identities = 75/242 (30%), Positives = 101/242 (41%), Gaps = 10/242 (4%)
Query: 3479 LCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDC 3538
L +I G P F+ +L C+ +F C + +C+ + ++CD + DC
Sbjct: 166 LRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDC 225
Query: 3539 SDGSDELALCPQRFCRLGQFQCSDGNCTS--PQTLCNAHQNCPDGSDEDRLLCENHH--- 3593
D SDEL C + + TS P+ + P LL +
Sbjct: 226 RDMSDELN-CEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLP 284
Query: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCA-SRTCRPGQFRCANGRCIPQAW 3652
C E C N CIP + CD DCED SDE C C P +F C NG C + W
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE--LDCGPPPPCEPNEFPCGNGHCALKLW 342
Query: 3653 KCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
+CD D DC D +DE +C T+F C + CIP C+ DC D SDE
Sbjct: 343 RCDGDFDCEDRTDEANCPTKRPEEVCGP-TQFRCVSTNMCIPASFHCDEESDCPDRSDEF 401
Query: 3713 GC 3714
GC
Sbjct: 402 GC 403
Score = 111 bits (278), Expect = 1e-23
Identities = 65/209 (31%), Positives = 84/209 (40%), Gaps = 56/209 (26%)
Query: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST------------------- 107
C + F C S +C+ + CD+ DC D SDE +C +
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDEL-NCEEPVLGISPTFSLLVETTSLPPR 257
Query: 108 ---------------------------CSSHQITCSNGQCIPSEYRCDHVRDCPDGADEN 140
C + C NG CIP +Y CD DC DG+DE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 141 DC-QYPTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDEINC-----TEICLHNEFSC-G 191
DC P CE + C NG C +CD DC D +DE NC E+C +F C
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS 377
Query: 192 NGECIPRAYVCDHDNDCQDGSDEHACNYP 220
CIP ++ CD ++DC D SDE C P
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDEFGCMPP 406
Score = 110 bits (275), Expect = 3e-23
Identities = 80/248 (32%), Positives = 101/248 (40%), Gaps = 32/248 (12%)
Query: 2820 RTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE----------NPTYCTTHTCSSSEF 2869
R C CH+ N C+ Y CD DC D SDE +PT+ +S
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 2870 QCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDN 2929
+ + + Q S P CG E C G CIP +++CDG
Sbjct: 257 RPET-TIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-------NGHCIPRDYLCDGQE 308
Query: 2930 DCGDMSDEDKRHQC-QNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC 2988
DC D SDE C C +EF C N C + W CDGD DC D DE
Sbjct: 309 DCEDGSDE---LDCGPPPPCEPNEFPCGNG-----HCALKLWRCDGDFDCEDRTDEANCP 360
Query: 2989 TRR---TCSENEFTC-GYGLCIPKIFRCDRHNDCGDYSDERGCL-YQTCQQNQFTCQNGR 3043
T+R C +F C +CIP F CD +DC D SDE GC+ Q + + Q R
Sbjct: 361 TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR 420
Query: 3044 CISKTFVC 3051
+ TF C
Sbjct: 421 GQTVTFTC 428
Score = 108 bits (271), Expect = 9e-23
Identities = 68/212 (32%), Positives = 92/212 (43%), Gaps = 17/212 (8%)
Query: 3633 RTCRPGQFRCAN-GRCIPQAWKCDVDNDCGDHSDE-----PIEECMSSAHLCDNFTEFSC 3686
R C +F C + C+ ++CD DC D SDE P+ + L T
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 3687 KTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCG 3746
+ + + V + S C P + C+N HCIP + CDGQ DC
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGS----VRPLPCGPQ-EAACRNGHCIPRDYLCDGQEDCE 311
Query: 3747 DNSDEENCAPRE-CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMR----TCHPE 3801
D SDE +C P C +EF C N C W CD DC D +DE +C + C P
Sbjct: 312 DGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPT 371
Query: 3802 YFQCTSGH-CVHSELKCDGSADCLDASDEADC 3832
F+C S + C+ + CD +DC D SDE C
Sbjct: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 108 bits (269), Expect = 2e-22
Identities = 67/207 (32%), Positives = 85/207 (41%), Gaps = 60/207 (28%)
Query: 108 CSSHQITC-SNGQCIPSEYRCDHVRDCPDGADENDCQYPTC------------------- 147
C+ + C S +C+ EYRCD DC D +DE +C+ P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 148 -----------------------------EQLTCDNGACYNTSQKCDWKVDCRDSSDEIN 178
++ C NG C CD + DC D SDE++
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 179 C--TEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT------CGGYQFTCP 230
C C NEF CGNG C + + CD D DC+D +DE C PT CG QF C
Sbjct: 319 CGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC--PTKRPEEVCGPTQFRCV 376
Query: 231 S-GRCIYQNWVCDGEDDCKDNGDEDGC 256
S CI ++ CD E DC D DE GC
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 107 bits (266), Expect = 4e-22
Identities = 80/235 (34%), Positives = 97/235 (41%), Gaps = 38/235 (16%)
Query: 2864 CSSSEFQCAS-GRCIPQHWYCDQETDCFDASDEPASC-----GHSERTCLADEFKCDGGR 2917
C+ +EF C S C+ + CD+ DC D SDE +C G S L E R
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDE-LNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 2918 CIPSEWICDGDNDCGDMSDEDKRHQCQNQ--------NCSDSEFLCVNDRPPDRRCIPQS 2969
P I M H Q C E C N CIP+
Sbjct: 258 --PETTI---------MRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGH-----CIPRD 301
Query: 2970 WVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC-- 3027
++CDG DC DG DE C NEF CG G C K++RCD DC D +DE C
Sbjct: 302 YLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPT 361
Query: 3028 --LYQTCQQNQFTC-QNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHE 3079
+ C QF C CI +F CDE++DC D SDE C P+ PP E
Sbjct: 362 KRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFG--CMPPQVVTPPRE 414
Score = 106 bits (265), Expect = 5e-22
Identities = 73/215 (33%), Positives = 89/215 (41%), Gaps = 17/215 (7%)
Query: 2904 RTCLADEFKCDG-GRCIPSEWICDGDNDCGDMSDEDKRHQCQNQ--NCSDSEFLCVNDRP 2960
R C EF C C+ E+ CD DC DMSDE C+ S + L V
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDE---LNCEEPVLGISPTFSLLVETTS 253
Query: 2961 ----PDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHN 3016
P+ + Q V G + C E C G CIP+ + CD
Sbjct: 254 LPPRPETTIMRQPPVTHAPQPLLPG-----SVRPLPCGPQEAACRNGHCIPRDYLCDGQE 308
Query: 3017 DCGDYSDERGC-LYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
DC D SDE C C+ N+F C NG C K + CD D DC D +DE PE C
Sbjct: 309 DCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVC 368
Query: 3076 PPHEFKC-DNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
P +F+C CI C+ DC D SDE GC
Sbjct: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 105 bits (263), Expect = 8e-22
Identities = 72/229 (31%), Positives = 103/229 (44%), Gaps = 14/229 (6%)
Query: 3594 CDSNEWQCAN-KRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAW 3652
C E+ C + C+ ++CD DC D SDE + P +P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3653 KCDVDNDCG-DHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDE 3711
+ + H+ +P+ C E +C+ N CIP+ +C+G +DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGP-QEAACR-NGHCIPRDYLCDGQEDCEDGSDE 316
Query: 3712 QGC-EERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRE----CTESEFRC 3766
C C P +F C N HC W+CDG DC D +DE NC + C ++FRC
Sbjct: 317 LDCGPPPPCEP-NEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 3767 VN-QQCIPSRWICDHYNDCGDNSDERDC---EMRTCHPEYFQCTSGHCV 3811
V+ CIP+ + CD +DC D SDE C ++ T E Q + G V
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTV 424
Score = 103 bits (257), Expect = 4e-21
Identities = 68/214 (31%), Positives = 86/214 (40%), Gaps = 63/214 (29%)
Query: 3756 PRECTESEFRCVN-QQCIPSRWICDHYNDCGDNSDERDCE-------------------- 3794
PR CTE+EF C + +C+ + CD DC D SDE +CE
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 3795 -------MR-------------------TCHPEYFQCTSGHCVHSELKCDGSADCLDASD 3828
MR C P+ C +GHC+ + CDG DC D SD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 3829 EADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCN---- 3884
E DC P C+ F C N C W+CDGD DC D +DE + P
Sbjct: 316 ELDCGPPPP----CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE-----ANCPTKRPEE 366
Query: 3885 --SPNRFRC-DNNRCIYSHEVCNGVDDCGDGTDE 3915
P +FRC N CI + C+ DC D +DE
Sbjct: 367 VCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 100 bits (249), Expect = 3e-20
Identities = 49/124 (39%), Positives = 62/124 (50%), Gaps = 8/124 (6%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA-VVTCQQGYFKCQSEGQCIPNSWV 86
C C +GHCIP D+ CDG +DC D +DE+ C C+ F C G C W
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPC-GNGHCALKLWR 343
Query: 87 CDQDQDCDDGSDERQDC----SQSTCSSHQITC-SNGQCIPSEYRCDHVRDCPDGADEND 141
CD D DC+D +DE +C + C Q C S CIP+ + CD DCPD +DE
Sbjct: 344 CDGDFDCEDRTDE-ANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFG 402
Query: 142 CQYP 145
C P
Sbjct: 403 CMPP 406
Score = 98.2 bits (243), Expect = 2e-19
Identities = 61/204 (29%), Positives = 82/204 (40%), Gaps = 51/204 (25%)
Query: 2700 CGASSFTC-SNGRCISEEWKCDNDNDCGDGSDEM---ESVCALHT--------------- 2740
C + F C S C++ E++CD DC D SDE+ E V +
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 2741 --------------------------CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAG 2774
C P C NG C+ Y CD DC DGSDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 2775 CLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP----DRTCQSGYTKCH 2830
C EF C N C + + C+G +C D +DE NCP + C +C
Sbjct: 319 CGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDR--TDEANCPTKRPEEVCGPTQFRCV 376
Query: 2831 NSNICIPRVYLCDGDNDCGDNSDE 2854
++N+CIP + CD ++DC D SDE
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDE 400
Score = 97.8 bits (242), Expect = 2e-19
Identities = 70/210 (33%), Positives = 84/210 (40%), Gaps = 46/210 (21%)
Query: 3796 RTCHPEYFQCTS-GHCVHSELKCDGSADCLDASDEADC--------PT------------ 3834
R C F C S CV E +CD DC D SDE +C PT
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 3835 -------RFPDGAY--------------CQATMFECKNHVCIPPYWKCDGDDDCGDGSDE 3873
R P + C C+N CIP + CDG +DC DGSDE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 3874 ELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEY 3933
L PC PN F C N C C+G DC D TDE ++P + C ++
Sbjct: 317 -LDCGPPPPCE-PNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRP-EEVCGPTQF 373
Query: 3934 KC-GNGHCIPHDNVCDDADDCGDWSDELGC 3962
+C CIP CD+ DC D SDE GC
Sbjct: 374 RCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 91.3 bits (225), Expect = 2e-17
Identities = 59/212 (27%), Positives = 77/212 (36%), Gaps = 55/212 (25%)
Query: 22 PASGQECDSAHFRCGS-GHCIPADWRCDGTKDCSDDADEIGC------------------ 62
P + C A F C S C+ ++RCD DC D +DE+ C
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 63 ----------------------------AVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCD 94
+ C C++ G CIP ++CD +DC+
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN-GHCIPRDYLCDGQEDCE 311
Query: 95 DGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCE------ 148
DGSDE C ++ C NG C +RCD DC D DE +C E
Sbjct: 312 DGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPT 371
Query: 149 QLTC-DNGACYNTSQKCDWKVDCRDSSDEINC 179
Q C C S CD + DC D SDE C
Sbjct: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 89.7 bits (221), Expect = 6e-17
Identities = 48/123 (39%), Positives = 60/123 (48%), Gaps = 9/123 (7%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCA-LHTCSPTAFTCANGRCVQYSY 2758
CG C NG CI ++ CD DC DGSDE++ C C P F C NG C +
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD--CGPPPPCEPNEFPCGNGHCALKLW 342
Query: 2759 RCDYYNDCGDGSDEAGCLFR---DCNATTEFMC-NNRRCIPREFICNGVDNCHDNNTSDE 2814
RCD DC D +DEA C + + T+F C + CIP F C+ +C D SDE
Sbjct: 343 RCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDR--SDE 400
Query: 2815 KNC 2817
C
Sbjct: 401 FGC 403
Score = 77.4 bits (189), Expect = 3e-13
Identities = 47/168 (27%), Positives = 65/168 (38%), Gaps = 52/168 (30%)
Query: 183 CLHNEFSCGN-GECIPRAYVCDHDNDCQDGSDEHACNYPT-------------------- 221
C EF+C + EC+ Y CD DC+D SDE C P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 222 --------------------------CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDG 255
CG + C +G CI ++++CDG++DC+D DE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 256 CESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTST 303
C P C P E+ C + +++ CDG DC R DE N T
Sbjct: 319 CGPPP----PCEPNEFPCGNGHCALKLWR-CDGDFDCEDRTDEANCPT 361
Score = 73.6 bits (179), Expect = 4e-12
Identities = 41/119 (34%), Positives = 55/119 (46%), Gaps = 11/119 (9%)
Query: 2669 GPNGAECQCPH-EGNWYLANNRKHCIVDNGER-------CGASSFTCSNGRCISEEWKCD 2720
GP A C+ H YL + ++ C + E C + F C NG C + W+CD
Sbjct: 286 GPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCD 345
Query: 2721 NDNDCGDGSDEMESVCAL--HTCSPTAFTCAN-GRCVQYSYRCDYYNDCGDGSDEAGCL 2776
D DC D +DE C PT F C + C+ S+ CD +DC D SDE GC+
Sbjct: 346 GDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCM 404
Score = 72.0 bits (175), Expect = 1e-11
Identities = 42/123 (34%), Positives = 54/123 (43%), Gaps = 12/123 (9%)
Query: 990 PVPNFQRVCGCPYGMRLASNHLTCEGDPTNEP--------PTEQCGLFSFPCKNGRCVPN 1041
P+P + C G + ++L C+G E P C FPC NG C
Sbjct: 282 PLPCGPQEAACRNGHCIPRDYL-CDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALK 340
Query: 1042 YYLCDGVDDCHDNSDEQLCGTL--NNTCSSSAFTC-GHGECIPAHWRCDKRNDCVDGSDE 1098
+ CDG DC D +DE C T C + F C CIPA + CD+ +DC D SDE
Sbjct: 341 LWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Query: 1099 HNC 1101
C
Sbjct: 401 FGC 403
Score = 57.8 bits (138), Expect = 3e-07
Identities = 41/139 (29%), Positives = 52/139 (37%), Gaps = 16/139 (11%)
Query: 3842 CQATMFECKNH-VCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH 3900
C F C ++ C+ ++CD DC D SDE + C P +
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDE-------LNCEEPVLGISPTFSLLVET 251
Query: 3901 EVCNGVDDCGDGTDETEEHCRKPT------PKPCTEYEYKCGNGHCIPHDNVCDDADDCG 3954
+ H +P P PC E C NGHCIP D +CD +DC
Sbjct: 252 TSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCE 311
Query: 3955 DWSDELGCNKGKERTCAEN 3973
D SDEL C G C N
Sbjct: 312 DGSDELDC--GPPPPCEPN 328
Score = 57.0 bits (136), Expect = 4e-07
Identities = 47/197 (23%), Positives = 67/197 (34%), Gaps = 58/197 (29%)
Query: 3030 QTCQQNQFTCQN-GRCISKTFVCDEDNDCGDGSDELM----------------------- 3065
+ C + +F C + C++ + CD DC D SDEL
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 3066 ----------HLCHTPEPT---------CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
+ H P+P C P E C NG CI LC+ +DC D SDE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 3107 KGCGINECHDPSISGC--------------DHNCTDTLTSFYC-SCRPGYKLMSDKRTCV 3151
CG +P+ C D +C D C + RP + CV
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 3152 DIDECTEMPFVCSQKCE 3168
+ C F C ++ +
Sbjct: 377 STNMCIPASFHCDEESD 393
Score = 44.7 bits (104), Expect = 0.002
Identities = 30/82 (36%), Positives = 36/82 (43%), Gaps = 7/82 (8%)
Query: 3468 PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIP 3527
PCG NG C+ L L + G F CE D +C TQF C + CIP
Sbjct: 331 PCG--NGHCA-LKLWRCDGD-FDCEDRTDEANCPTKRPE---EVCGPTQFRCVSTNMCIP 383
Query: 3528 IWWKCDGQKDCSDGSDELALCP 3549
+ CD + DC D SDE P
Sbjct: 384 ASFHCDEESDCPDRSDEFGCMP 405
Score = 39.7 bits (91), Expect = 0.071
Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 3925 PKPCTEYEYKCGN-GHCIPHDNVCDDADDCGDWSDELGCNK 3964
P+ CTE E+ C + C+ + CD DC D SDEL C +
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEE 236
Score = 39.7 bits (91), Expect = 0.071
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 3/36 (8%)
Query: 4379 PPCR---CMHGGNCYFDETDLPKCKCPSGYTGKYCE 4411
P CR C +GG C+ E+ C CP+G+TG CE
Sbjct: 3846 PTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCE 3881
Score = 37.7 bits (86), Expect = 0.27
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 16/88 (18%)
Query: 4335 KQICSHLCLLRPGG---YSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYF 4391
+Q C H P G + C C G +G E + E P L PC +HGG C
Sbjct: 4110 RQPCQHGATCMPAGEYEFQCLCRDG---FKGDLCEHE---ENPCQLREPC--LHGGTCQG 4161
Query: 4392 DETDLPKCKCPSGYTGKYCEMAFSKGIS 4419
+C C G++G C+ GI+
Sbjct: 4162 T-----RCLCLPGFSGPRCQQGSGHGIA 4184
Score = 33.5 bits (75), Expect = 5.1
Identities = 36/149 (24%), Positives = 53/149 (35%), Gaps = 34/149 (22%)
Query: 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFY 3134
C P + +G + +LC +C +SD CH P C C +
Sbjct: 1544 CAPGYTRTGSGLYLGHCELC----ECNGHSDL-------CH-PETGACSQ-CQHNAAGEF 1590
Query: 3135 CS-CRPGYKLMSDKRTCVDIDEC----TEMPFVCSQKCENV--------------IGSYI 3175
C C PGY + T D C T + S+ CE++ G Y
Sbjct: 1591 CELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYC 1650
Query: 3176 CKCAPGYLREP--DGKTCRQNSNIEPYLI 3202
+C PGY+ P G C +N P ++
Sbjct: 1651 EQCGPGYVGNPSVQGGQCLPETNQAPLVV 1679
Score = 32.7 bits (73), Expect = 8.6
Identities = 55/242 (22%), Positives = 76/242 (31%), Gaps = 30/242 (12%)
Query: 133 CPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
CP G CQ +G T ++C E + C H+
Sbjct: 1128 CPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRC 1187
Query: 193 GECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252
+C P Y D Q G+ + C C G + + + DG C
Sbjct: 1188 EQCQPGYY-----GDAQRGTPQD-CQLCPCYGDPAAGQAAHTCFLD--TDGHPTC----- 1234
Query: 253 EDGCESGPHDVH--KCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMT 310
D C G H +C+P + P G + C PG N G S
Sbjct: 1235 -DACSPGHSGRHCERCAPGYYGNPSQG------QPCQRDSQVPGPIGCNCDPQGSVSSQ- 1286
Query: 311 LCSALNCQYQCHETPYGGAC-FCPPGYI-INHNDSRTCVEFDDCQIWGICDQKCESRPGR 368
C A Q QC G C C P + ++ ++ C+ C GI Q S R
Sbjct: 1287 -CDAAG-QCQCKAQVEGLTCSHCRPHHFHLSASNPDGCL---PCFCMGITQQCASSAYTR 1341
Query: 369 HL 370
HL
Sbjct: 1342 HL 1343
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 126 bits (317), Expect = 4e-28
Identities = 80/237 (33%), Positives = 119/237 (50%), Gaps = 16/237 (6%)
Query: 3229 VVALDFDRVEKRLYWIDTQRQVIERMFLNK-TNKETIINHRLPAAESLAVDWVSRKLYWL 3287
+V +D+D E+ +YW D + I R L ETI+N L + E LA+D + R +YW
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT 1203
Query: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFD--NPRGLALHPQYGYLYWADWGHRA- 3344
D+ LD + + L+G R++L F D NPR +A+ P G LYW DW A
Sbjct: 1204 DSVLDKIESALLDGSERKVL----------FYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
Query: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
I +DG N+ ++I+T + PNG+T D + LL WADA +E + +G R + +
Sbjct: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN 1313
Query: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGS-NRQTLVNTTHRPFDIHVYHPY 3460
L +PF+I + D Y TDW V NK+ G + L + I +PY
Sbjct: 1314 N-LKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPY 1369
Score = 124 bits (311), Expect = 2e-27
Identities = 79/235 (33%), Positives = 127/235 (54%), Gaps = 10/235 (4%)
Query: 1464 NGSYIVAVDFDSISGRIFWSDATQGKTWS--AFQNGTDRRVVFDSSIILTETIAIDWVGR 1521
+GS IV +D+D ++W+D G+T S + G + + +S +I E +AID + R
Sbjct: 1140 HGSIIVGIDYDCRERMVYWTDVA-GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRR 1198
Query: 1522 NLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH-PRIE 1580
+YWTD L+ IE + +DGS R VL +L NPR +A+DP L+W+DW P+IE
Sbjct: 1199 TMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN--LYWTDWNREAPKIE 1256
Query: 1581 RASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDL 1640
+S+DG R +++ I P GLT D ++LL + D+ ++ C R+VI ++L
Sbjct: 1257 TSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLE-CTLPDGTGRRVIQNNL 1315
Query: 1641 IIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPL-GIVAVHP 1694
++P+++ + D Y TD V+ NK G + + L GI AV+P
Sbjct: 1316 --KYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYP 1368
Score = 123 bits (309), Expect = 4e-27
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 6/206 (2%)
Query: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
++ +DYD +Y+T IS A L G T++ SG+ + +G+A D I R +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGR---TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTM 1200
Query: 2481 YYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHA-KIERATL 2537
Y++D + I S DGS R V+ + PRAI +DP +G LYW DW+ A KIE ++L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 2538 GGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFG 2597
G R ++N+ + +P+GLT D LL W DA +++E + G R VI N + F
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS 1320
Query: 2598 LTLYGQYIYWTDLYTQRIYRANKYDG 2623
+ Y + Y TD + NK+ G
Sbjct: 1321 IVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 123 bits (308), Expect = 5e-27
Identities = 79/245 (32%), Positives = 129/245 (52%), Gaps = 9/245 (3%)
Query: 706 AVQNFLIFSSQVAIRGIPF--TLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKH 763
+V FL+++ I +P T ++ +S + S VGID+D ++ ++++D++
Sbjct: 1105 SVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGR 1164
Query: 764 MIFKQKID-GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV 822
I + ++ G E + + + + E LA D I + +YWTDS I L D + R V+
Sbjct: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIE-SALLDGSERKVL 1223
Query: 823 QY--LNNPRSVVVHPFAGYLFFTDWFRPA-KIMRAWSDGSHLLPVINTTLGWPNGLAIDW 879
Y L NPR++ V P G L++TDW R A KI + DG + +INT +G PNGL D
Sbjct: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
Query: 880 AASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRV 939
+ L W DA K+E + DG RR + + + +PF + + +H + TDWR ++ V
Sbjct: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQN--NLKYPFSIVSYADHFYHTDWRRDGVVSV 1341
Query: 940 RKADG 944
K G
Sbjct: 1342 NKHSG 1346
Score = 122 bits (307), Expect = 6e-27
Identities = 68/235 (28%), Positives = 120/235 (51%), Gaps = 7/235 (2%)
Query: 420 SQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDIN-GLNIQEVLNVSVETPENLAVDWVN 478
S + + VG+ + + V+WTD + + G + ++N + +PE LA+D +
Sbjct: 1138 SLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIR 1197
Query: 479 NKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKL 538
+Y ++ +++I+ LDGS R L +L +PR IAVDP G L+++DW + PK+
Sbjct: 1198 RTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREA--PKI 1255
Query: 539 ERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGG 598
E + +DG NR+ L+ T +G P G+T D SK + W D+ +E DG R+ + +
Sbjct: 1256 ETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN- 1314
Query: 599 SLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYY-QASLRPYGVTVYH 652
+ +PF + + + TDW + V+ NK + Y + YG+T +
Sbjct: 1315 --LKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVY 1367
Score = 117 bits (293), Expect = 3e-25
Identities = 64/160 (40%), Positives = 93/160 (58%), Gaps = 2/160 (1%)
Query: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
++ P+G+A+D + R +YW+D +IE A LDG RK L TDL P AIAV+P G ++
Sbjct: 1185 LISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLY 1244
Query: 4201 WTDWGKE-PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKY 4259
WTDW +E PKIE++ ++GE+R IL+ D+G P GL+ D + + W+D +E
Sbjct: 1245 WTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK-LLCWADAGTKKLECTLP 1303
Query: 4260 DGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 4299
DGT RRVI P+S+ + D Y + V NK
Sbjct: 1304 DGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
Score = 84.0 bits (206), Expect = 3e-15
Identities = 67/249 (26%), Positives = 113/249 (45%), Gaps = 15/249 (6%)
Query: 1747 FLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGL--DVEFDDAEQYIYWVENPGE-IHR 1803
FL+ + I + LN DA + + + +++D E+ +YW + G I R
Sbjct: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
Query: 1804 VKTD-GTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIA 1862
+ G + ++ P LA+D I R +Y T+ IE L G RK L
Sbjct: 1169 AGLELGAEPETIVNSGLISPE-GLAIDHIRRTMYWTDSVLDKIESALLDGS--ERKVLFY 1225
Query: 1863 NDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLE 1922
D + P I VDP RG LYW+D ++ KI ++++DG + + L ++
Sbjct: 1226 TD-----LVNPRAIAVDPIRGNLYWTDWNREA---PKIETSSLDGENRRILINTDIGLPN 1277
Query: 1923 CVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEV 1982
+T D + L WA G +E DGT R ++ + L +P+ I + Y+TD + +
Sbjct: 1278 GLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDG 1337
Query: 1983 IERVDKATG 1991
+ V+K +G
Sbjct: 1338 VVSVNKHSG 1346
Score = 75.1 bits (183), Expect = 2e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 11/198 (5%)
Query: 2082 DHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHG 2141
D ++T++ + G + +D D +YW D + S + G+ IV G
Sbjct: 1131 DAAKTLLSL--HGSIIVGIDYDCRERMVYWTDVAGRTISRAGLEL----GAEPETIVNSG 1184
Query: 2142 IGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKN 2201
+ G+A+D + +Y+T++ + + IE ++ + R+VL + PR I VDP
Sbjct: 1185 L--ISPEGLAIDHIRRTMYWTDSVLDK--IESALLDGSERKVLFYTDLVNPRAIAVDPIR 1240
Query: 2202 RYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
L+W D+ + PKIE S LD NR +L++ I P GL D + W D +
Sbjct: 1241 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLEC 1300
Query: 2261 IRINGENSEVIRYGSRYP 2278
+G VI+ +YP
Sbjct: 1301 TLPDGTGRRVIQNNLKYP 1318
Score = 60.1 bits (144), Expect = 5e-08
Identities = 46/157 (29%), Positives = 62/157 (39%), Gaps = 34/157 (21%)
Query: 3051 CDEDNDCGDGSDELMHLCHTPEPTC------------PPHEFKCDNGRCIEMMKLCNHLD 3098
C ++N+C G H C P C +EF D CI + N +
Sbjct: 799 CVDENECATG----FHRCG-PNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCE 853
Query: 3099 DCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE 3158
D G + C + C H+ T F C+C PGY D C D+DEC+E
Sbjct: 854 D----------GSHTCAPAGQARCVHHGGST---FSCACLPGYA--GDGHQCTDVDECSE 898
Query: 3159 MPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNS 3195
+ C N GS+ C+C PGY DG C +S
Sbjct: 899 NRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCIPDS 933
Score = 52.8 bits (125), Expect = 8e-06
Identities = 59/211 (27%), Positives = 75/211 (35%), Gaps = 53/211 (25%)
Query: 1243 CIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE 1302
C CD C G+ C C S Y D NC+ DE
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTC---ECASGY-QGDGRNCV----------------DE 802
Query: 1303 KDCPTQPFRCPSWQWQCLGHNICVNL--SVVCDGIFDCPNG---TDESPLC-----NGNS 1352
+C T RC +++C+NL S C+ C +G D+ C N
Sbjct: 803 NECATGFHRCGP-------NSVCINLPGSYRCE----CRSGYEFADDRHTCILITPPANP 851
Query: 1353 CSDFNGGCTH----ECVQEPFGA-KCLCPLGFLLANDSKTCEDIDECDILGSC--SQHCY 1405
C D + C CV C C G+ A D C D+DEC C + CY
Sbjct: 852 CEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSE-NRCHPAATCY 908
Query: 1406 NMRGSFRCSCDTGYMLESDGRTCKVTASESL 1436
N GSF C C GY DG C ++ SL
Sbjct: 909 NTPGSFSCRCQPGYY--GDGFQCIPDSTSSL 937
Score = 49.7 bits (117), Expect = 7e-05
Identities = 50/207 (24%), Positives = 72/207 (34%), Gaps = 50/207 (24%)
Query: 3867 CGDGSDEELHLC-----------LDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
C DGS H+C +D C + ++ D C+ +E G CG +
Sbjct: 763 CYDGS----HMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNS-- 816
Query: 3916 TEEHCRKPTPKPC---TEYEYKCGNGHCI---PHDNVCDDADDCGDWSDELGCNKGKERT 3969
P C + YE+ CI P N C+D T
Sbjct: 817 --VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGS----------------HT 858
Query: 3970 CAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH-CRNTKGSY 4028
CA + C F C+C G+ D C D++EC + P C NT GS+
Sbjct: 859 CAP-AGQARCVHHGGSTFSCACLPGYAG---DGHQCTDVDECSENRCHPAATCYNTPGSF 914
Query: 4029 ECVCADGFTSMSDRPGKRCAAEGSSPL 4055
C C G+ G +C + +S L
Sbjct: 915 SCRCQPGYYG----DGFQCIPDSTSSL 937
Score = 49.7 bits (117), Expect = 7e-05
Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 4/90 (4%)
Query: 864 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAI-- 921
++N+ L P GLAID +YW D+ DKIE + DG +R+ L + + + +P +A+
Sbjct: 1180 IVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTD-LVNPRAIAVDP 1238
Query: 922 FGEHLFFTDW-RLGAIIRVRKADGGEMTVI 950
+L++TDW R I DG ++
Sbjct: 1239 IRGNLYWTDWNREAPKIETSSLDGENRRIL 1268
Score = 47.4 bits (111), Expect = 3e-04
Identities = 31/89 (34%), Positives = 38/89 (42%), Gaps = 16/89 (17%)
Query: 3112 NECHDPSISGCDHNCTDTL-------TSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVC- 3163
N C+D S H C T + C C GY+ D R CVD +EC C
Sbjct: 761 NPCYDGS-----HMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCG 813
Query: 3164 -SQKCENVIGSYICKCAPGYLREPDGKTC 3191
+ C N+ GSY C+C GY D TC
Sbjct: 814 PNSVCINLPGSYRCECRSGYEFADDRHTC 842
Score = 46.6 bits (109), Expect = 6e-04
Identities = 49/219 (22%), Positives = 73/219 (33%), Gaps = 49/219 (22%)
Query: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHG-------ECIPA 1082
S P C ++CD CH + ++ TC ++ G G EC
Sbjct: 755 SDPTPGNPCYDGSHMCDTTARCHPGTG------VDYTCECASGYQGDGRNCVDENECATG 808
Query: 1083 HWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKN 1142
RC + C++ + C + ++ D H CI + N C DGS
Sbjct: 809 FHRCGPNSVCINLPGSYRCECRS-----GYEFADDRHTCI---LITPPANPCEDGS---- 856
Query: 1143 CNSTETCQPS-QFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCI 1201
TC P+ Q C +H +F C C+ +C D+C
Sbjct: 857 ----HTCAPAGQARCVHHG--GSTFSC-------------ACLPGYAGDGHQCTDVDEC- 896
Query: 1202 GVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQED 1240
NRC C + C +P + D FQC D
Sbjct: 897 -SENRCHPAATCYNTPGSFSCRCQPG--YYGDGFQCIPD 932
Score = 44.7 bits (104), Expect = 0.002
Identities = 53/189 (28%), Positives = 69/189 (36%), Gaps = 44/189 (23%)
Query: 206 NDCQDGSDEHACN-----YPTCG-GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESG 259
N C DGS H C+ +P G Y C SG YQ D ++ DE+ C +G
Sbjct: 761 NPCYDGS--HMCDTTARCHPGTGVDYTCECASG---YQG-------DGRNCVDENECATG 808
Query: 260 PHDVHKCSPREW--SCPESGRCI--SIYKVCDGILDC-----PGREDENNTSTGKYCSMT 310
H+C P + P S RC S Y+ D C P E+ + T
Sbjct: 809 ---FHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
Query: 311 LCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQK--CESRPGR 368
C H +C C PGY D C + D+C C C + PG
Sbjct: 866 RC--------VHHGGSTFSCACLPGYA---GDGHQCTDVDECSE-NRCHPAATCYNTPGS 913
Query: 369 HLCHCEEGY 377
C C+ GY
Sbjct: 914 FSCRCQPGY 922
Score = 43.1 bits (100), Expect = 0.006
Identities = 28/92 (30%), Positives = 38/92 (41%), Gaps = 8/92 (8%)
Query: 1343 DESPLCNGNSCSDFNGGCTHECVQEP---FGAKCLCPLGFLLANDSKTCEDIDECDI-LG 1398
++S GN C D + C P C C G+ D + C D +EC
Sbjct: 753 EDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFH 810
Query: 1399 SCSQH--CYNMRGSFRCSCDTGYMLESDGRTC 1428
C + C N+ GS+RC C +GY D TC
Sbjct: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
Score = 39.7 bits (91), Expect = 0.071
Identities = 58/214 (27%), Positives = 69/214 (32%), Gaps = 59/214 (27%)
Query: 2723 NDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNA 2782
N C DGS H C TA C G V DY +C G G R+C
Sbjct: 761 NPCYDGS---------HMCDTTA-RCHPGTGV------DYTCECASGYQGDG---RNCVD 801
Query: 2783 TTEFMCNNRRCIPREFICN--GVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICI---P 2837
E RC P N G C C+SGY + + CI P
Sbjct: 802 ENECATGFHRCGPNSVCINLPGSYRCE--------------CRSGYEFADDRHTCILITP 847
Query: 2838 RVYLC-DGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEP 2896
C DG + C + C H S F CA C+P Y C D +
Sbjct: 848 PANPCEDGSHTC---APAGQARCVHH--GGSTFSCA---CLP--GYAGDGHQCTDVDECS 897
Query: 2897 ASCGHSERTC--LADEFKC--------DGGRCIP 2920
+ H TC F C DG +CIP
Sbjct: 898 ENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIP 931
Score = 36.2 bits (82), Expect = 0.78
Identities = 61/271 (22%), Positives = 83/271 (30%), Gaps = 69/271 (25%)
Query: 3606 CIPESWQCDTFNDCEDNSDED-SSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHS 3664
C S CDT C + D + CAS G+ C +C ++ C +
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
Query: 3665 DEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
EC S D+ + CI + + C D S TC P G
Sbjct: 823 GSYRCECRSGYEFADD--------RHTCI---LITPPANPCEDGS-------HTCAPAGQ 864
Query: 3725 FRCKNH-------HCIP----LRWQCDGQNDCGDNSDEENCAPREC---TESEFRCVNQ- 3769
RC +H C+P QC ++C +N C P T F C Q
Sbjct: 865 ARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSEN----RCHPAATCYNTPGSFSCRCQP 920
Query: 3770 -------QCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVH---------- 3812
QCIP S CE + H + G H
Sbjct: 921 GYYGDGFQCIPD-----------STSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNF 969
Query: 3813 SELKCDGSAD---CLDASDEADCPTRFPDGA 3840
L+C GS C+D T+ P G+
Sbjct: 970 LPLQCHGSTGFCWCVDPDGHEVPGTQTPPGS 1000
Score = 35.8 bits (81), Expect = 1.0
Identities = 34/137 (24%), Positives = 45/137 (32%), Gaps = 33/137 (24%)
Query: 27 ECDSAHFRCGSGH-CI--PADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPN 83
EC + RCG CI P +RC+ C+ GY CI
Sbjct: 804 ECATGFHRCGPNSVCINLPGSYRCE------------------CRSGYEFADDRHTCI-- 843
Query: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ 143
+ C+DGS Q+ C H + + C+P H D EN C
Sbjct: 844 -LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRC- 901
Query: 144 YPTCEQLTCDNGACYNT 160
+P CYNT
Sbjct: 902 HPA--------ATCYNT 910
Score = 35.0 bits (79), Expect = 1.7
Identities = 55/236 (23%), Positives = 78/236 (33%), Gaps = 50/236 (21%)
Query: 157 CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA 216
CY+ S CD C + ++ T C G C +N+C G H
Sbjct: 763 CYDGSHMCDTTARCHPGTG-VDYTCECASGYQGDGRN--------CVDENECATGF--HR 811
Query: 217 C-------NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPR 269
C N P G Y+ C SG + D + CE G H C+P
Sbjct: 812 CGPNSVCINLP--GSYRCECRSG----YEFADDRHTCILITPPANPCEDGSHT---CAPA 862
Query: 270 EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQ--YQCHETPYG 327
RC+ PG + + T + CS C C+ TP
Sbjct: 863 G-----QARCVHHGGSTFSCACLPGYAGDGHQCT----DVDECSENRCHPAATCYNTPGS 913
Query: 328 GACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCE------SRPGR--HLCHCEE 375
+C C PGY + D C+ D C+Q+ + PG H+ C+E
Sbjct: 914 FSCRCQPGY---YGDGFQCIP-DSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDE 965
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 126 bits (316), Expect = 6e-28
Identities = 89/342 (26%), Positives = 128/342 (37%), Gaps = 82/342 (23%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-TCGHGE------ 1078
C F C NG+C+P + C+ +D+C D+SDE++C N +++AF C + +
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 1079 ------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCI--------SK 1124
C+P +CD DC+D DE +C L Y N +
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
Query: 1125 NWVCDTDN----------------------DCGDGSDEK-----------NCNSTETCQP 1151
W+ DT + DG +E + ++ T
Sbjct: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
Query: 1152 SQFNCPNHRCIDLSFVCDG-------DKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT 1204
S H C D G D C+ G C Q +C
Sbjct: 327 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRC---------- 376
Query: 1205 NRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN 1264
DG + C + DE C MC +EF C +G+C P C+ C GSDE N
Sbjct: 377 ---DGYWHCPNGRDETNCT-----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 428
Query: 1265 ACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
C FHC N C+ +W+CD +DCGD SDE++CP
Sbjct: 429 CFF---CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
Score = 123 bits (308), Expect = 5e-27
Identities = 101/337 (29%), Positives = 136/337 (40%), Gaps = 68/337 (20%)
Query: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPI-----EECMSSAHLCDNFTEFSCKTN 3689
C QFRC NG+CIP+AWKC+ ++CGD SDE I ++A + +F C +
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 3690 ----YRCIPKWAVCNGVDDCRDNSDEQGCEERTC-----HPVGDFRCKNH-HCIPLRWQC 3739
Y C+P+ C+G DC D DE C+ TC + G F N+ P C
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
Query: 3740 DGQNDCGDNSD-------------------------EENCAP--RECTESEFRCVNQQCI 3772
D GD+ EEN R T +
Sbjct: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
Query: 3773 PSRWICDHYNDCGDNSDERDCEMRT------CHPEYFQCTSGH-CVHSELKCDGSADCLD 3825
S I H+ C D + T C P C C + +CDG C +
Sbjct: 327 SSGQIRVHF--CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 384
Query: 3826 ASDEADCPTRFPDGAYCQATMFEC-KNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVPC 3883
DE +C CQ F C +N VC P +C+ + C +GSDE+ C
Sbjct: 385 GRDETNC-------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC----- 432
Query: 3884 NSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
P F C NNRC++ VC+ DDCGDG+D EE+C
Sbjct: 433 -QPGNFHCKNNRCVFESWVCDSQDDCGDGSD--EENC 466
Score = 111 bits (278), Expect = 1e-23
Identities = 98/351 (27%), Positives = 139/351 (39%), Gaps = 86/351 (24%)
Query: 2770 SDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT-------- 2821
S+E C A +F C N +CIP + CN +D C D +SDE+ C
Sbjct: 142 SEEPNC------ACDQFRCGNGKCIPEAWKCNNMDECGD--SSDEEICAKEANPPTAAAF 193
Query: 2822 ---------CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
C S +TK + C+P CDG+ DC D DE C TC
Sbjct: 194 QPCAYNQFQCLSRFTKVYT---CLPESLKCDGNIDCLDLGDE--IDCDVPTC-------- 240
Query: 2873 SGRCIPQHWYCDQETDCFDASDEPASC-------GHSERTCLADEFKCDGGRCIPSEWIC 2925
G+ + + + D ++C H + +FK DG I
Sbjct: 241 -GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 299
Query: 2926 DGDND-------------------CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCI 2966
DG + S + + H C ++ + F D C+
Sbjct: 300 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCL 357
Query: 2967 P------QSWVC-------DGDVDCTDGYDENQNCTRRTCSENEFTCG-YGLCIPKIFRC 3012
P +W C DG C +G DE NCT C + EF C G+C P+ RC
Sbjct: 358 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT--MCQKEEFPCSRNGVCYPRSDRC 414
Query: 3013 DRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
+ N C + SDE+ C + CQ F C+N RC+ +++VCD +DCGDGSDE
Sbjct: 415 NYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
Score = 105 bits (263), Expect = 8e-22
Identities = 101/353 (28%), Positives = 129/353 (36%), Gaps = 66/353 (18%)
Query: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH--------CDSNEWQCANK 3604
C QF+C +G C CN C D SDE+ E + C N++QC ++
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 3605 -----RCIPESWQCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAW 3652
C+PES +CD DC D DE C TC G F N P
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
Query: 3653 KCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
C D GDH + FT+F G D D
Sbjct: 265 NCTWLIDTGDHRKVILR-----------FTDFKLDGT-----------GYGDYVKIYD-- 300
Query: 3713 GCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA---------PRECTESE 3763
G EE + + H GQ +D+ N A C E
Sbjct: 301 GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWE 360
Query: 3764 FRCV-NQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCT-SGHCVHSELKCDGSA 3821
C N C + CD Y C + DE +C M C E F C+ +G C +C+
Sbjct: 361 IPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQN 418
Query: 3822 DCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
C + SDE +C +CQ F CKN+ C+ W CD DDCGDGSDEE
Sbjct: 419 HCPNGSDEKNC-------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEE 464
Score = 103 bits (258), Expect = 3e-21
Identities = 96/327 (29%), Positives = 133/327 (40%), Gaps = 59/327 (18%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC------PTHAPAS-CLDTQYTCDN- 1118
C+ F CG+G+CIP W+C+ ++C D SDE C PT A C Q+ C +
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 1119 ----HQCISKNWVCDTDNDCGDGSDEKNCNSTETCQP------SQFNCPN---------- 1158
+ C+ ++ CD + DC D DE +C+ TC FN PN
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCD-VPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
Query: 1159 ---------HRCIDLSFVC-----DGDKDCV---DGSDEVGCVLNCTASQFKCASGDKCI 1201
HR + L F G D V DG +E L + F + +
Sbjct: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
Query: 1202 GVTNRCDGVFDCSDNSDEA---GCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLY 1258
+ + F C+D + A + G C E C + C CDG+ C
Sbjct: 326 SSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 384
Query: 1259 GSDEHNACVPKTCPSSYFHCD-NGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
G DE N + C F C NG C R+ C+ N C + SDEK+C F C +
Sbjct: 385 GRDETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGNF 437
Query: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDE 1344
C +N CV S VCD DC +G+DE
Sbjct: 438 HCK-NNRCVFESWVCDSQDDCGDGSDE 463
Score = 102 bits (254), Expect = 9e-21
Identities = 45/104 (43%), Positives = 60/104 (57%), Gaps = 4/104 (3%)
Query: 154 NGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDNDCQDGS 212
N CY Q+CD C + DE NCT +C EF C NG C PR+ C++ N C +GS
Sbjct: 366 NWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGS 424
Query: 213 DEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
DE C + C F C + RC++++WVCD +DDC D DE+ C
Sbjct: 425 DEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 101 bits (252), Expect = 2e-20
Identities = 98/350 (28%), Positives = 129/350 (36%), Gaps = 91/350 (26%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTA----------FTCA 2749
C F C NG+CI E WKC+N ++CGD SD E +CA PTA F C
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSD--EEICAKEANPPTAAAFQPCAYNQFQCL 204
Query: 2750 NG-----RCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC---------------- 2788
+ C+ S +CD DC D DE C C ++
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
Query: 2789 ---------NNRRCIPR--EFICNGV---------DNCHDNN-------TSDEKNCP-DR 2820
++R+ I R +F +G D +N T+ + + P
Sbjct: 265 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 324
Query: 2821 TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG-RCIPQ 2879
SG + H C +V G N TY C E C C +
Sbjct: 325 VSSSGQIRVH---FCADKVNAARG---------FNATYQVDGFCLPWEIPCGGNWGCYTE 372
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCD-GGRCIPSEWICDGDNDCGDMSDED 2938
CD C + DE +C C +EF C G C P C+ N C + SDE
Sbjct: 373 QQRCDGYWHCPNGRDE-TNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK 427
Query: 2939 KRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC 2988
CQ N F C N+ RC+ +SWVCD DC DG DE +NC
Sbjct: 428 NCFFCQPGN-----FHCKNN-----RCVFESWVCDSQDDCGDGSDE-ENC 466
Score = 100 bits (248), Expect = 4e-20
Identities = 94/345 (27%), Positives = 132/345 (38%), Gaps = 63/345 (18%)
Query: 2812 SDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDEN--------PTYCTTHT 2863
S+E NC C +C N CIP + C+ ++CGD+SDE PT
Sbjct: 142 SEEPNC---ACDQ--FRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
Query: 2864 CSSSEFQCASG-----RCIPQHWYCDQETDCFDASDE----PASCGHSERTCLAD----- 2909
C+ ++FQC S C+P+ CD DC D DE +CG +
Sbjct: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 255
Query: 2910 --EFKCDGGRCIPSEWICD-GDN------------DCGDMSDEDKRHQCQNQNCSDS-EF 2953
+F G C W+ D GD+ D D K + +N
Sbjct: 256 YPDFYPPGSNCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 312
Query: 2954 LCVNDRPPDRRCIPQSW-----VCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIP 3007
L D + S C V+ G++ C E CG C
Sbjct: 313 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG-FCLPWEIPCGGNWGCYT 371
Query: 3008 KIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC-QNGRCISKTFVCDEDNDCGDGSDELMH 3066
+ RCD + C + DE C CQ+ +F C +NG C ++ C+ N C +GSDE
Sbjct: 372 EQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
Query: 3067 LCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGI 3111
C P F C N RC+ +C+ DDC D SDE+ C +
Sbjct: 430 FF------CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 468
Score = 98.2 bits (243), Expect = 2e-19
Identities = 98/374 (26%), Positives = 129/374 (34%), Gaps = 117/374 (31%)
Query: 3497 FRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG 3556
FR SG + P C+ QF C N KCIP WKC+ +C D SDE
Sbjct: 133 FRLAYFSGKSE-EPNCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDE------------ 178
Query: 3557 QFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-----RCIPESW 3611
+C N P + C N++QC ++ C+PES
Sbjct: 179 -------------EICAKEANPPTAA-------AFQPCAYNQFQCLSRFTKVYTCLPESL 218
Query: 3612 QCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAWKCDVDNDCGDH- 3663
+CD DC D DE C TC G F N P C D GDH
Sbjct: 219 KCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHR 276
Query: 3664 -----------------------------------------SDEPIEECMSS----AHLC 3678
S P+ SS H C
Sbjct: 277 KVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFC 336
Query: 3679 DNFTEFSCKTNYR------CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVG--------- 3723
+ + N C+P C G C +++Q C+ P G
Sbjct: 337 ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGC--YTEQQRCDGYWHCPNGRDETNCTMC 394
Query: 3724 ---DFRC-KNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICD 3779
+F C +N C P +C+ QN C + SDE+NC C F C N +C+ W+CD
Sbjct: 395 QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF--FCQPGNFHCKNNRCVFESWVCD 452
Query: 3780 HYNDCGDNSDERDC 3793
+DCGD SDE +C
Sbjct: 453 SQDDCGDGSDEENC 466
Score = 92.8 bits (229), Expect = 7e-18
Identities = 86/327 (26%), Positives = 118/327 (36%), Gaps = 82/327 (25%)
Query: 3715 EERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAP----------RECTESEF 3764
EE C FRC N CIP W+C+ ++CGD+SDEE CA + C ++F
Sbjct: 143 EEPNC-ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
Query: 3765 RCVNQ-----QCIPSRWICDHYNDCGDNSDERDCEMRTCHP--EYFQCTSGHCVHSELKC 3817
+C+++ C+P CD DC D DE DC++ TC +YF T + +
Sbjct: 202 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYP 261
Query: 3818 DGSADC---LDASDEADCPTRFPD--------GAYCQA-TMFECKNHVCIPPYWKCDGDD 3865
GS +C +D D RF D G Y + E H + D
Sbjct: 262 PGS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 320
Query: 3866 D---CGDGSDEELHLCLDVPCNSPNRFR---------------CDNN-RCIYSHEVCNGV 3906
+H C D N+ F C N C + C+G
Sbjct: 321 PLTVVSSSGQIRVHFCAD-KVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGY 379
Query: 3907 DDCGDGTDET---------------------------EEHCRKPTPKP----CTEYEYKC 3935
C +G DET + HC + + C + C
Sbjct: 380 WHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHC 439
Query: 3936 GNGHCIPHDNVCDDADDCGDWSDELGC 3962
N C+ VCD DDCGD SDE C
Sbjct: 440 KNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 89.0 bits (219), Expect = 1e-16
Identities = 86/332 (25%), Positives = 117/332 (35%), Gaps = 72/332 (21%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT----------CQQGYFKCQSE 77
C FRCG+G CIP W+C+ +C D +DE CA C F+C S
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
Query: 78 GQ----CIPNSWVCDQDQDCDDGSDERQDCSQSTCSS---HQITCSNGQCIPSEY----R 126
C+P S CD + DC D DE DC TC + N P Y
Sbjct: 207 FTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
Query: 127 CDHVRDCPD--------------------------GADENDCQYPTCEQLTCDNGACYNT 160
C + D D G +EN + LT + T
Sbjct: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENP--HKLLRVLTAFDSHAPLT 323
Query: 161 SQKCDWKVDCRDSSDEINCTE----------ICLHNEFSCG-NGECIPRAYVCDHDNDCQ 209
++ +D++N CL E CG N C CD C
Sbjct: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCP 383
Query: 210 DGSDEHACNYPTCGGYQFTCP-SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSP 268
+G DE C C +F C +G C ++ C+ ++ C + DE C C P
Sbjct: 384 NGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-------FFCQP 434
Query: 269 REWSCPESGRCISIYKVCDGILDCPGREDENN 300
+ C ++ RC+ VCD DC DE N
Sbjct: 435 GNFHC-KNNRCVFESWVCDSQDDCGDGSDEEN 465
Score = 80.1 bits (196), Expect = 5e-14
Identities = 44/111 (39%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCA-NGRCVQYSYRCDYYNDCG 2767
N C +E+ +CD C +G DE C + C F C+ NG C S RC+Y N C
Sbjct: 366 NWGCYTEQQRCDGYWHCPNGRDETN--CTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCP 421
Query: 2768 DGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP 2818
+GSDE C F C F C N RC+ ++C+ D+C D SDE+NCP
Sbjct: 422 NGSDEKNCFF--CQ-PGNFHCKNNRCVFESWVCDSQDDCGDG--SDEENCP 467
Score = 79.0 bits (193), Expect = 1e-13
Identities = 41/110 (37%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 3729 NHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDN 3787
N C + +CDG C + DE NC C + EF C N C P C++ N C +
Sbjct: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
Query: 3788 SDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
SDE++C C P F C + CV CD DC D SDE +CP P
Sbjct: 424 SDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
Score = 76.3 bits (186), Expect = 7e-13
Identities = 38/107 (35%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 36 GSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDD 95
G+ C RCDG C + DE C + CQ+ F C G C P S C+ C +
Sbjct: 365 GNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPN 422
Query: 96 GSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
GSDE+ +C C C N +C+ + CD DC DG+DE +C
Sbjct: 423 GSDEK-NC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 75.1 bits (183), Expect = 2e-12
Identities = 48/159 (30%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 2855 NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDC--FDASDEPASCGH---------SE 2903
N + T T + E A G IP + Q+ F + D + G E
Sbjct: 85 NLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 144
Query: 2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN-------QNCSDSEFLCV 2956
C D+F+C G+CIP W C+ ++CGD SDE+ + N Q C+ ++F C+
Sbjct: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
Query: 2957 NDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSE 2995
+ C+P+S CDG++DC D DE +C TC +
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDE-IDCDVPTCGQ 242
Score = 73.9 bits (180), Expect = 3e-12
Identities = 83/323 (25%), Positives = 110/323 (34%), Gaps = 114/323 (35%)
Query: 137 ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-----------EICLH 185
++E +C C+Q C NG C + KC+ +C DSSDE C + C +
Sbjct: 142 SEEPNC---ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
Query: 186 NEFSCGNG-----ECIPRAYVCDHDNDCQDGSDEHACNYPTCGGY--------------Q 226
N+F C + C+P + CD + DC D DE C+ PTCG +
Sbjct: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPD 258
Query: 227 FTCPSGRCIYQNWVCDGED---------DCKDNGD--------EDGCESGPHD------- 262
F P C W+ D D D K +G DG E PH
Sbjct: 259 FYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 315
Query: 263 -----------------VHKCSPR------------------EWSCPESGR--CISIYKV 285
VH C+ + W P G C + +
Sbjct: 316 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQR 375
Query: 286 CDGILDCPGREDENNTSTGKY----CSMT-LC--SALNCQYQCHETPYG----GACFCPP 334
CDG CP DE N + + CS +C + C YQ H P G FC P
Sbjct: 376 CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNH-CPNGSDEKNCFFCQP 434
Query: 335 GYIINHN-----DSRTCVEFDDC 352
G N +S C DDC
Sbjct: 435 GNFHCKNNRCVFESWVCDSQDDC 457
Score = 73.6 bits (179), Expect = 4e-12
Identities = 51/166 (30%), Positives = 70/166 (42%), Gaps = 22/166 (13%)
Query: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRL 1006
+TV+ S +H + VN G NA Q FC P ++ CG +G
Sbjct: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQ-------VDGFCLP---WEIPCGGNWGCYT 371
Query: 1007 ASNHLTCEG-----DPTNEPPTEQCGLFSFPC-KNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
C+G + +E C FPC +NG C P C+ + C + SDE+ C
Sbjct: 372 EQQR--CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
Query: 1061 GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAP 1106
C F C + C+ W CD ++DC DGSDE NCP P
Sbjct: 430 FF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
Score = 72.8 bits (177), Expect = 8e-12
Identities = 40/119 (33%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 75 QSEGQCIP------NSWVCDQDQDCDDG----SDERQDCSQSTCSSHQITCS-NGQCIPS 123
Q +G C+P +W C +Q DG + R + + + C + CS NG C P
Sbjct: 351 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPR 410
Query: 124 EYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI 182
RC++ CP+G+DE +C + C N C S CD + DC D SDE NC I
Sbjct: 411 SDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
Score = 72.4 bits (176), Expect = 1e-11
Identities = 39/97 (40%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCS-NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
+G W+ N R N C F CS NG C +C+ N C +GSDE
Sbjct: 377 DGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-- 431
Query: 2739 HTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
C P F C N RCV S+ CD +DCGDGSDE C
Sbjct: 432 --CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 71.6 bits (174), Expect = 2e-11
Identities = 84/345 (24%), Positives = 117/345 (33%), Gaps = 74/345 (21%)
Query: 973 ACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFP 1032
AC+Q NG C + N CG + + E +P + C F
Sbjct: 148 ACDQFRCGNGKCIPEAWKCNNMDE-CGDSSDEEICAK----EANPPTAAAFQPCAYNQFQ 202
Query: 1033 C-----KNGRCVPNYYLCDGVDDCHDNSDEQLC-------------GTLNN--------- 1065
C K C+P CDG DC D DE C GT N+
Sbjct: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
Query: 1066 --TCSSSAFTCGHGECIP--AHWRCDKRN-----DCVDGSDEHN---------CPTHAPA 1107
C+ T H + I ++ D DG +E+ +HAP
Sbjct: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 322
Query: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET----CQPSQFNCP-NHRCI 1162
+ + + H C K + + N+T C P + C N C
Sbjct: 323 TVVSSSGQIRVHFCADKV------------NAARGFNATYQVDGFCLPWEIPCGGNWGCY 370
Query: 1163 DLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
CDG C +G DE C + C +F C+ C ++RC+ C + SDE C
Sbjct: 371 TEQQRCDGYWHCPNGRDETNCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
Query: 1223 PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACV 1267
C F C+ + C+ W CD DC GSDE N V
Sbjct: 430 -----FFCQPGNFHCKNNR-CVFESWVCDSQDDCGDGSDEENCPV 468
Score = 70.1 bits (170), Expect = 5e-11
Identities = 48/150 (32%), Positives = 63/150 (42%), Gaps = 11/150 (7%)
Query: 1080 IPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCD-NHQCISKNWVCDTDNDCGDGS 1138
I H+ DK V+ + N CL + C N C ++ CD C +G
Sbjct: 331 IRVHFCADK----VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386
Query: 1139 DEKNCNSTETCQPSQFNCP-NHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
DE NC CQ +F C N C S C+ C +GSDE C C F C +
Sbjct: 387 DETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCKN- 441
Query: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
++C+ + CD DC D SDE CP P
Sbjct: 442 NRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
Score = 69.7 bits (169), Expect = 6e-11
Identities = 69/303 (22%), Positives = 98/303 (32%), Gaps = 69/303 (22%)
Query: 54 SDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST------ 107
S ++E CA C Q F+C G+CIP +W C+ +C D SDE ++
Sbjct: 139 SGKSEEPNCA---CDQ--FRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 192
Query: 108 ---CSSHQITCSNG-----QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
C+ +Q C + C+P +CD DC D DE DC PTC Q +N
Sbjct: 193 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFN 252
Query: 160 T---------SQKCDWKVDCRDSSDEI--------------------------------N 178
+ C W +D D I
Sbjct: 253 SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 312
Query: 179 CTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSG-RCIYQ 237
T H + + R + C + G + C ++ C C +
Sbjct: 313 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 372
Query: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
CDG C + DE C C E+ C +G C C+ CP D
Sbjct: 373 QQRCDGYWHCPNGRDETNCT-------MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSD 425
Query: 298 ENN 300
E N
Sbjct: 426 EKN 428
Score = 63.5 bits (153), Expect = 5e-09
Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 14/90 (15%)
Query: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC---------NSTETCQPSQFNCPN 1158
+C Q+ C N +CI + W C+ ++CGD SDE+ C + + C +QF C +
Sbjct: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
Query: 1159 -----HRCIDLSFVCDGDKDCVDGSDEVGC 1183
+ C+ S CDG+ DC+D DE+ C
Sbjct: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
Score = 58.9 bits (141), Expect = 1e-07
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 13/97 (13%)
Query: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCP--TRPPGM-----CHSDEFQC- 1237
NC QF+C +G KCI +C+ + +C D+SDE C PP C ++FQC
Sbjct: 146 NCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
Query: 1238 ---QEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
+ C+P +CDG+ DCL DE + VP TC
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP-TC 240
Score = 58.5 bits (140), Expect = 1e-07
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 17/100 (17%)
Query: 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC------PT----QPFRCPSWQWQCL 1320
C F C NG CI AW C+ ++CGD SDE+ C PT QP C Q+QCL
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP--CAYNQFQCL 204
Query: 1321 GH----NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDF 1356
C+ S+ CDG DC + DE C+ +C +
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEID-CDVPTCGQW 243
Score = 57.8 bits (138), Expect = 3e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 14/89 (15%)
Query: 3887 NRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRK----PTP---KPCTEYEYKCGNGH 3939
++FRC N +CI CN +D+CGD +DE E C K PT +PC +++C +
Sbjct: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCLSRF 207
Query: 3940 -----CIPHDNVCDDADDCGDWSDELGCN 3963
C+P CD DC D DE+ C+
Sbjct: 208 TKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
Score = 55.1 bits (131), Expect = 2e-06
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISG---CDHN--- 3125
EP C +F+C NG+CI CN++D+C D+SDE+ C E + P+ + C +N
Sbjct: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICA-KEANPPTAAAFQPCAYNQFQ 202
Query: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDI-DECTEMPFVCSQKCENVIGSYICKCAPGYLR 3184
C T Y +C P C+D+ DE C Q + G++ P +
Sbjct: 203 CLSRFTKVY-TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 260
Query: 3185 EPDGKTC 3191
P G C
Sbjct: 261 -PPGSNC 266
Score = 55.1 bits (131), Expect = 2e-06
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 2637 PRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNR----KHC 2692
P G N ++Q+C+ NG C E C G Y ++R HC
Sbjct: 362 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK-EEFPCSRNGVCYPRSDRCNYQNHC 420
Query: 2693 IVDNGER----CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
+ E+ C +F C N RC+ E W CD+ +DCGDGSDE
Sbjct: 421 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
Score = 44.7 bits (104), Expect = 0.002
Identities = 22/54 (40%), Positives = 28/54 (51%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
C +F CKN RCV ++CD DDC D SDE+ C + T +A G C
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 485
Score = 44.3 bits (103), Expect = 0.003
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
C +++CGNG CIP C++ D+CGD SDE C K
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 183
Score = 41.2 bits (95), Expect = 0.024
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
C +F C + C+ W CD DC D +DE C V+
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
Score = 39.7 bits (91), Expect = 0.071
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 11/81 (13%)
Query: 1312 CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGA 1371
C W+ C G+ C CDG + CPNG DE+ N C C+ V P
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSD 412
Query: 1372 KC----LCPLGFLLANDSKTC 1388
+C CP G +D K C
Sbjct: 413 RCNYQNHCPNG----SDEKNC 429
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 126 bits (316), Expect = 6e-28
Identities = 89/342 (26%), Positives = 128/342 (37%), Gaps = 82/342 (23%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-TCGHGE------ 1078
C F C NG+C+P + C+ +D+C D+SDE++C N +++AF C + +
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 1079 ------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCI--------SK 1124
C+P +CD DC+D DE +C L Y N +
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
Query: 1125 NWVCDTDN----------------------DCGDGSDEK-----------NCNSTETCQP 1151
W+ DT + DG +E + ++ T
Sbjct: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
Query: 1152 SQFNCPNHRCIDLSFVCDG-------DKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT 1204
S H C D G D C+ G C Q +C
Sbjct: 346 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRC---------- 395
Query: 1205 NRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN 1264
DG + C + DE C MC +EF C +G+C P C+ C GSDE N
Sbjct: 396 ---DGYWHCPNGRDETNCT-----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 447
Query: 1265 ACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
C FHC N C+ +W+CD +DCGD SDE++CP
Sbjct: 448 CFF---CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
Score = 123 bits (308), Expect = 5e-27
Identities = 101/337 (29%), Positives = 136/337 (40%), Gaps = 68/337 (20%)
Query: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPI-----EECMSSAHLCDNFTEFSCKTN 3689
C QFRC NG+CIP+AWKC+ ++CGD SDE I ++A + +F C +
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 3690 ----YRCIPKWAVCNGVDDCRDNSDEQGCEERTC-----HPVGDFRCKNH-HCIPLRWQC 3739
Y C+P+ C+G DC D DE C+ TC + G F N+ P C
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
Query: 3740 DGQNDCGDNSD-------------------------EENCAP--RECTESEFRCVNQQCI 3772
D GD+ EEN R T +
Sbjct: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
Query: 3773 PSRWICDHYNDCGDNSDERDCEMRT------CHPEYFQCTSGH-CVHSELKCDGSADCLD 3825
S I H+ C D + T C P C C + +CDG C +
Sbjct: 346 SSGQIRVHF--CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403
Query: 3826 ASDEADCPTRFPDGAYCQATMFEC-KNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVPC 3883
DE +C CQ F C +N VC P +C+ + C +GSDE+ C
Sbjct: 404 GRDETNC-------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC----- 451
Query: 3884 NSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
P F C NNRC++ VC+ DDCGDG+D EE+C
Sbjct: 452 -QPGNFHCKNNRCVFESWVCDSQDDCGDGSD--EENC 485
Score = 111 bits (278), Expect = 1e-23
Identities = 98/351 (27%), Positives = 139/351 (39%), Gaps = 86/351 (24%)
Query: 2770 SDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT-------- 2821
S+E C A +F C N +CIP + CN +D C D +SDE+ C
Sbjct: 161 SEEPNC------ACDQFRCGNGKCIPEAWKCNNMDECGD--SSDEEICAKEANPPTAAAF 212
Query: 2822 ---------CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
C S +TK + C+P CDG+ DC D DE C TC
Sbjct: 213 QPCAYNQFQCLSRFTKVYT---CLPESLKCDGNIDCLDLGDE--IDCDVPTC-------- 259
Query: 2873 SGRCIPQHWYCDQETDCFDASDEPASC-------GHSERTCLADEFKCDGGRCIPSEWIC 2925
G+ + + + D ++C H + +FK DG I
Sbjct: 260 -GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 318
Query: 2926 DGDND-------------------CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCI 2966
DG + S + + H C ++ + F D C+
Sbjct: 319 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCL 376
Query: 2967 P------QSWVC-------DGDVDCTDGYDENQNCTRRTCSENEFTCG-YGLCIPKIFRC 3012
P +W C DG C +G DE NCT C + EF C G+C P+ RC
Sbjct: 377 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT--MCQKEEFPCSRNGVCYPRSDRC 433
Query: 3013 DRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
+ N C + SDE+ C + CQ F C+N RC+ +++VCD +DCGDGSDE
Sbjct: 434 NYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
Score = 105 bits (263), Expect = 8e-22
Identities = 101/353 (28%), Positives = 129/353 (36%), Gaps = 66/353 (18%)
Query: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH--------CDSNEWQCANK 3604
C QF+C +G C CN C D SDE+ E + C N++QC ++
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 3605 -----RCIPESWQCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAW 3652
C+PES +CD DC D DE C TC G F N P
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
Query: 3653 KCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
C D GDH + FT+F G D D
Sbjct: 284 NCTWLIDTGDHRKVILR-----------FTDFKLDGT-----------GYGDYVKIYD-- 319
Query: 3713 GCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA---------PRECTESE 3763
G EE + + H GQ +D+ N A C E
Sbjct: 320 GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWE 379
Query: 3764 FRCV-NQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCT-SGHCVHSELKCDGSA 3821
C N C + CD Y C + DE +C M C E F C+ +G C +C+
Sbjct: 380 IPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQN 437
Query: 3822 DCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
C + SDE +C +CQ F CKN+ C+ W CD DDCGDGSDEE
Sbjct: 438 HCPNGSDEKNC-------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEE 483
Score = 103 bits (258), Expect = 3e-21
Identities = 96/327 (29%), Positives = 133/327 (40%), Gaps = 59/327 (18%)
Query: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC------PTHAPAS-CLDTQYTCDN- 1118
C+ F CG+G+CIP W+C+ ++C D SDE C PT A C Q+ C +
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 1119 ----HQCISKNWVCDTDNDCGDGSDEKNCNSTETCQP------SQFNCPN---------- 1158
+ C+ ++ CD + DC D DE +C+ TC FN PN
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCD-VPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
Query: 1159 ---------HRCIDLSFVC-----DGDKDCV---DGSDEVGCVLNCTASQFKCASGDKCI 1201
HR + L F G D V DG +E L + F + +
Sbjct: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
Query: 1202 GVTNRCDGVFDCSDNSDEA---GCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLY 1258
+ + F C+D + A + G C E C + C CDG+ C
Sbjct: 345 SSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403
Query: 1259 GSDEHNACVPKTCPSSYFHCD-NGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
G DE N + C F C NG C R+ C+ N C + SDEK+C F C +
Sbjct: 404 GRDETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGNF 456
Query: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDE 1344
C +N CV S VCD DC +G+DE
Sbjct: 457 HCK-NNRCVFESWVCDSQDDCGDGSDE 482
Score = 102 bits (254), Expect = 9e-21
Identities = 45/104 (43%), Positives = 60/104 (57%), Gaps = 4/104 (3%)
Query: 154 NGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDNDCQDGS 212
N CY Q+CD C + DE NCT +C EF C NG C PR+ C++ N C +GS
Sbjct: 385 NWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGS 443
Query: 213 DEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
DE C + C F C + RC++++WVCD +DDC D DE+ C
Sbjct: 444 DEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 101 bits (252), Expect = 2e-20
Identities = 98/350 (28%), Positives = 129/350 (36%), Gaps = 91/350 (26%)
Query: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTA----------FTCA 2749
C F C NG+CI E WKC+N ++CGD SD E +CA PTA F C
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSD--EEICAKEANPPTAAAFQPCAYNQFQCL 223
Query: 2750 NG-----RCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC---------------- 2788
+ C+ S +CD DC D DE C C ++
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
Query: 2789 ---------NNRRCIPR--EFICNGV---------DNCHDNN-------TSDEKNCP-DR 2820
++R+ I R +F +G D +N T+ + + P
Sbjct: 284 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 343
Query: 2821 TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG-RCIPQ 2879
SG + H C +V G N TY C E C C +
Sbjct: 344 VSSSGQIRVH---FCADKVNAARG---------FNATYQVDGFCLPWEIPCGGNWGCYTE 391
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCD-GGRCIPSEWICDGDNDCGDMSDED 2938
CD C + DE +C C +EF C G C P C+ N C + SDE
Sbjct: 392 QQRCDGYWHCPNGRDE-TNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK 446
Query: 2939 KRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC 2988
CQ N F C N+ RC+ +SWVCD DC DG DE +NC
Sbjct: 447 NCFFCQPGN-----FHCKNN-----RCVFESWVCDSQDDCGDGSDE-ENC 485
Score = 100 bits (248), Expect = 4e-20
Identities = 94/345 (27%), Positives = 132/345 (38%), Gaps = 63/345 (18%)
Query: 2812 SDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDEN--------PTYCTTHT 2863
S+E NC C +C N CIP + C+ ++CGD+SDE PT
Sbjct: 161 SEEPNC---ACDQ--FRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 214
Query: 2864 CSSSEFQCASG-----RCIPQHWYCDQETDCFDASDE----PASCGHSERTCLAD----- 2909
C+ ++FQC S C+P+ CD DC D DE +CG +
Sbjct: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 274
Query: 2910 --EFKCDGGRCIPSEWICD-GDN------------DCGDMSDEDKRHQCQNQNCSDS-EF 2953
+F G C W+ D GD+ D D K + +N
Sbjct: 275 YPDFYPPGSNCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 331
Query: 2954 LCVNDRPPDRRCIPQSW-----VCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGL-CIP 3007
L D + S C V+ G++ C E CG C
Sbjct: 332 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG-FCLPWEIPCGGNWGCYT 390
Query: 3008 KIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC-QNGRCISKTFVCDEDNDCGDGSDELMH 3066
+ RCD + C + DE C CQ+ +F C +NG C ++ C+ N C +GSDE
Sbjct: 391 EQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
Query: 3067 LCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGI 3111
C P F C N RC+ +C+ DDC D SDE+ C +
Sbjct: 449 FF------CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 487
Score = 98.2 bits (243), Expect = 2e-19
Identities = 98/374 (26%), Positives = 129/374 (34%), Gaps = 117/374 (31%)
Query: 3497 FRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG 3556
FR SG + P C+ QF C N KCIP WKC+ +C D SDE
Sbjct: 152 FRLAYFSGKSE-EPNCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDE------------ 197
Query: 3557 QFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-----RCIPESW 3611
+C N P + C N++QC ++ C+PES
Sbjct: 198 -------------EICAKEANPPTAA-------AFQPCAYNQFQCLSRFTKVYTCLPESL 237
Query: 3612 QCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAWKCDVDNDCGDH- 3663
+CD DC D DE C TC G F N P C D GDH
Sbjct: 238 KCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHR 295
Query: 3664 -----------------------------------------SDEPIEECMSS----AHLC 3678
S P+ SS H C
Sbjct: 296 KVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFC 355
Query: 3679 DNFTEFSCKTNYR------CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVG--------- 3723
+ + N C+P C G C +++Q C+ P G
Sbjct: 356 ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGC--YTEQQRCDGYWHCPNGRDETNCTMC 413
Query: 3724 ---DFRC-KNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICD 3779
+F C +N C P +C+ QN C + SDE+NC C F C N +C+ W+CD
Sbjct: 414 QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF--FCQPGNFHCKNNRCVFESWVCD 471
Query: 3780 HYNDCGDNSDERDC 3793
+DCGD SDE +C
Sbjct: 472 SQDDCGDGSDEENC 485
Score = 92.8 bits (229), Expect = 7e-18
Identities = 86/327 (26%), Positives = 118/327 (36%), Gaps = 82/327 (25%)
Query: 3715 EERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAP----------RECTESEF 3764
EE C FRC N CIP W+C+ ++CGD+SDEE CA + C ++F
Sbjct: 162 EEPNC-ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
Query: 3765 RCVNQ-----QCIPSRWICDHYNDCGDNSDERDCEMRTCHP--EYFQCTSGHCVHSELKC 3817
+C+++ C+P CD DC D DE DC++ TC +YF T + +
Sbjct: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYP 280
Query: 3818 DGSADC---LDASDEADCPTRFPD--------GAYCQA-TMFECKNHVCIPPYWKCDGDD 3865
GS +C +D D RF D G Y + E H + D
Sbjct: 281 PGS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 339
Query: 3866 D---CGDGSDEELHLCLDVPCNSPNRFR---------------CDNN-RCIYSHEVCNGV 3906
+H C D N+ F C N C + C+G
Sbjct: 340 PLTVVSSSGQIRVHFCAD-KVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGY 398
Query: 3907 DDCGDGTDET---------------------------EEHCRKPTPKP----CTEYEYKC 3935
C +G DET + HC + + C + C
Sbjct: 399 WHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHC 458
Query: 3936 GNGHCIPHDNVCDDADDCGDWSDELGC 3962
N C+ VCD DDCGD SDE C
Sbjct: 459 KNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 89.0 bits (219), Expect = 1e-16
Identities = 86/332 (25%), Positives = 117/332 (35%), Gaps = 72/332 (21%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT----------CQQGYFKCQSE 77
C FRCG+G CIP W+C+ +C D +DE CA C F+C S
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
Query: 78 GQ----CIPNSWVCDQDQDCDDGSDERQDCSQSTCSS---HQITCSNGQCIPSEY----R 126
C+P S CD + DC D DE DC TC + N P Y
Sbjct: 226 FTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
Query: 127 CDHVRDCPD--------------------------GADENDCQYPTCEQLTCDNGACYNT 160
C + D D G +EN + LT + T
Sbjct: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENP--HKLLRVLTAFDSHAPLT 342
Query: 161 SQKCDWKVDCRDSSDEINCTE----------ICLHNEFSCG-NGECIPRAYVCDHDNDCQ 209
++ +D++N CL E CG N C CD C
Sbjct: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCP 402
Query: 210 DGSDEHACNYPTCGGYQFTCP-SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSP 268
+G DE C C +F C +G C ++ C+ ++ C + DE C C P
Sbjct: 403 NGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-------FFCQP 453
Query: 269 REWSCPESGRCISIYKVCDGILDCPGREDENN 300
+ C ++ RC+ VCD DC DE N
Sbjct: 454 GNFHC-KNNRCVFESWVCDSQDDCGDGSDEEN 484
Score = 80.1 bits (196), Expect = 5e-14
Identities = 44/111 (39%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCA-NGRCVQYSYRCDYYNDCG 2767
N C +E+ +CD C +G DE C + C F C+ NG C S RC+Y N C
Sbjct: 385 NWGCYTEQQRCDGYWHCPNGRDETN--CTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCP 440
Query: 2768 DGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP 2818
+GSDE C F C F C N RC+ ++C+ D+C D SDE+NCP
Sbjct: 441 NGSDEKNCFF--CQ-PGNFHCKNNRCVFESWVCDSQDDCGDG--SDEENCP 486
Score = 79.0 bits (193), Expect = 1e-13
Identities = 41/110 (37%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 3729 NHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDN 3787
N C + +CDG C + DE NC C + EF C N C P C++ N C +
Sbjct: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
Query: 3788 SDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
SDE++C C P F C + CV CD DC D SDE +CP P
Sbjct: 443 SDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 76.3 bits (186), Expect = 7e-13
Identities = 38/107 (35%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 36 GSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDD 95
G+ C RCDG C + DE C + CQ+ F C G C P S C+ C +
Sbjct: 384 GNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPN 441
Query: 96 GSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
GSDE+ +C C C N +C+ + CD DC DG+DE +C
Sbjct: 442 GSDEK-NC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 75.1 bits (183), Expect = 2e-12
Identities = 48/159 (30%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 2855 NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDC--FDASDEPASCGH---------SE 2903
N + T T + E A G IP + Q+ F + D + G E
Sbjct: 104 NLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
Query: 2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN-------QNCSDSEFLCV 2956
C D+F+C G+CIP W C+ ++CGD SDE+ + N Q C+ ++F C+
Sbjct: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
Query: 2957 NDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSE 2995
+ C+P+S CDG++DC D DE +C TC +
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDE-IDCDVPTCGQ 261
Score = 73.9 bits (180), Expect = 3e-12
Identities = 83/323 (25%), Positives = 110/323 (34%), Gaps = 114/323 (35%)
Query: 137 ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-----------EICLH 185
++E +C C+Q C NG C + KC+ +C DSSDE C + C +
Sbjct: 161 SEEPNC---ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 217
Query: 186 NEFSCGNG-----ECIPRAYVCDHDNDCQDGSDEHACNYPTCGGY--------------Q 226
N+F C + C+P + CD + DC D DE C+ PTCG +
Sbjct: 218 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPD 277
Query: 227 FTCPSGRCIYQNWVCDGED---------DCKDNGD--------EDGCESGPHD------- 262
F P C W+ D D D K +G DG E PH
Sbjct: 278 FYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 334
Query: 263 -----------------VHKCSPR------------------EWSCPESGR--CISIYKV 285
VH C+ + W P G C + +
Sbjct: 335 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQR 394
Query: 286 CDGILDCPGREDENNTSTGKY----CSMT-LC--SALNCQYQCHETPYG----GACFCPP 334
CDG CP DE N + + CS +C + C YQ H P G FC P
Sbjct: 395 CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNH-CPNGSDEKNCFFCQP 453
Query: 335 GYIINHN-----DSRTCVEFDDC 352
G N +S C DDC
Sbjct: 454 GNFHCKNNRCVFESWVCDSQDDC 476
Score = 73.6 bits (179), Expect = 4e-12
Identities = 51/166 (30%), Positives = 70/166 (42%), Gaps = 22/166 (13%)
Query: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRL 1006
+TV+ S +H + VN G NA Q FC P ++ CG +G
Sbjct: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQ-------VDGFCLP---WEIPCGGNWGCYT 390
Query: 1007 ASNHLTCEG-----DPTNEPPTEQCGLFSFPC-KNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
C+G + +E C FPC +NG C P C+ + C + SDE+ C
Sbjct: 391 EQQR--CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
Query: 1061 GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAP 1106
C F C + C+ W CD ++DC DGSDE NCP P
Sbjct: 449 FF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 72.8 bits (177), Expect = 8e-12
Identities = 40/119 (33%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 75 QSEGQCIP------NSWVCDQDQDCDDG----SDERQDCSQSTCSSHQITCS-NGQCIPS 123
Q +G C+P +W C +Q DG + R + + + C + CS NG C P
Sbjct: 370 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPR 429
Query: 124 EYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI 182
RC++ CP+G+DE +C + C N C S CD + DC D SDE NC I
Sbjct: 430 SDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
Score = 72.4 bits (176), Expect = 1e-11
Identities = 39/97 (40%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCS-NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
+G W+ N R N C F CS NG C +C+ N C +GSDE
Sbjct: 396 DGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-- 450
Query: 2739 HTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
C P F C N RCV S+ CD +DCGDGSDE C
Sbjct: 451 --CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 71.6 bits (174), Expect = 2e-11
Identities = 84/345 (24%), Positives = 117/345 (33%), Gaps = 74/345 (21%)
Query: 973 ACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFP 1032
AC+Q NG C + N CG + + E +P + C F
Sbjct: 167 ACDQFRCGNGKCIPEAWKCNNMDE-CGDSSDEEICAK----EANPPTAAAFQPCAYNQFQ 221
Query: 1033 C-----KNGRCVPNYYLCDGVDDCHDNSDEQLC-------------GTLNN--------- 1065
C K C+P CDG DC D DE C GT N+
Sbjct: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
Query: 1066 --TCSSSAFTCGHGECIP--AHWRCDKRN-----DCVDGSDEHN---------CPTHAPA 1107
C+ T H + I ++ D DG +E+ +HAP
Sbjct: 282 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 341
Query: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET----CQPSQFNCP-NHRCI 1162
+ + + H C K + + N+T C P + C N C
Sbjct: 342 TVVSSSGQIRVHFCADKV------------NAARGFNATYQVDGFCLPWEIPCGGNWGCY 389
Query: 1163 DLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
CDG C +G DE C + C +F C+ C ++RC+ C + SDE C
Sbjct: 390 TEQQRCDGYWHCPNGRDETNCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
Query: 1223 PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACV 1267
C F C+ + C+ W CD DC GSDE N V
Sbjct: 449 -----FFCQPGNFHCKNNR-CVFESWVCDSQDDCGDGSDEENCPV 487
Score = 70.1 bits (170), Expect = 5e-11
Identities = 48/150 (32%), Positives = 63/150 (42%), Gaps = 11/150 (7%)
Query: 1080 IPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCD-NHQCISKNWVCDTDNDCGDGS 1138
I H+ DK V+ + N CL + C N C ++ CD C +G
Sbjct: 350 IRVHFCADK----VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 405
Query: 1139 DEKNCNSTETCQPSQFNCP-NHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
DE NC CQ +F C N C S C+ C +GSDE C C F C +
Sbjct: 406 DETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCKN- 460
Query: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
++C+ + CD DC D SDE CP P
Sbjct: 461 NRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
Score = 69.7 bits (169), Expect = 6e-11
Identities = 69/303 (22%), Positives = 98/303 (32%), Gaps = 69/303 (22%)
Query: 54 SDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST------ 107
S ++E CA C Q F+C G+CIP +W C+ +C D SDE ++
Sbjct: 158 SGKSEEPNCA---CDQ--FRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 211
Query: 108 ---CSSHQITCSNG-----QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
C+ +Q C + C+P +CD DC D DE DC PTC Q +N
Sbjct: 212 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFN 271
Query: 160 T---------SQKCDWKVDCRDSSDEI--------------------------------N 178
+ C W +D D I
Sbjct: 272 SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 331
Query: 179 CTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSG-RCIYQ 237
T H + + R + C + G + C ++ C C +
Sbjct: 332 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 391
Query: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
CDG C + DE C C E+ C +G C C+ CP D
Sbjct: 392 QQRCDGYWHCPNGRDETNCT-------MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSD 444
Query: 298 ENN 300
E N
Sbjct: 445 EKN 447
Score = 63.5 bits (153), Expect = 5e-09
Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 14/90 (15%)
Query: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC---------NSTETCQPSQFNCPN 1158
+C Q+ C N +CI + W C+ ++CGD SDE+ C + + C +QF C +
Sbjct: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
Query: 1159 -----HRCIDLSFVCDGDKDCVDGSDEVGC 1183
+ C+ S CDG+ DC+D DE+ C
Sbjct: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
Score = 58.9 bits (141), Expect = 1e-07
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 13/97 (13%)
Query: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCP--TRPPGM-----CHSDEFQC- 1237
NC QF+C +G KCI +C+ + +C D+SDE C PP C ++FQC
Sbjct: 165 NCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
Query: 1238 ---QEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
+ C+P +CDG+ DCL DE + VP TC
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP-TC 259
Score = 58.5 bits (140), Expect = 1e-07
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 17/100 (17%)
Query: 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC------PT----QPFRCPSWQWQCL 1320
C F C NG CI AW C+ ++CGD SDE+ C PT QP C Q+QCL
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP--CAYNQFQCL 223
Query: 1321 GH----NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDF 1356
C+ S+ CDG DC + DE C+ +C +
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEID-CDVPTCGQW 262
Score = 57.8 bits (138), Expect = 3e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 14/89 (15%)
Query: 3887 NRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRK----PTP---KPCTEYEYKCGNGH 3939
++FRC N +CI CN +D+CGD +DE E C K PT +PC +++C +
Sbjct: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCLSRF 226
Query: 3940 -----CIPHDNVCDDADDCGDWSDELGCN 3963
C+P CD DC D DE+ C+
Sbjct: 227 TKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
Score = 55.1 bits (131), Expect = 2e-06
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISG---CDHN--- 3125
EP C +F+C NG+CI CN++D+C D+SDE+ C E + P+ + C +N
Sbjct: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICA-KEANPPTAAAFQPCAYNQFQ 221
Query: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDI-DECTEMPFVCSQKCENVIGSYICKCAPGYLR 3184
C T Y +C P C+D+ DE C Q + G++ P +
Sbjct: 222 CLSRFTKVY-TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 279
Query: 3185 EPDGKTC 3191
P G C
Sbjct: 280 -PPGSNC 285
Score = 55.1 bits (131), Expect = 2e-06
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 2637 PRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNR----KHC 2692
P G N ++Q+C+ NG C E C G Y ++R HC
Sbjct: 381 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK-EEFPCSRNGVCYPRSDRCNYQNHC 439
Query: 2693 IVDNGER----CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
+ E+ C +F C N RC+ E W CD+ +DCGDGSDE
Sbjct: 440 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
Score = 44.7 bits (104), Expect = 0.002
Identities = 22/54 (40%), Positives = 28/54 (51%)
Query: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
C +F CKN RCV ++CD DDC D SDE+ C + T +A G C
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 504
Score = 44.3 bits (103), Expect = 0.003
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
C +++CGNG CIP C++ D+CGD SDE C K
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
Score = 41.2 bits (95), Expect = 0.024
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
C +F C + C+ W CD DC D +DE C V+
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
Score = 39.7 bits (91), Expect = 0.071
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 11/81 (13%)
Query: 1312 CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGA 1371
C W+ C G+ C CDG + CPNG DE+ N C C+ V P
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSD 431
Query: 1372 KC----LCPLGFLLANDSKTC 1388
+C CP G +D K C
Sbjct: 432 RCNYQNHCPNG----SDEKNC 448
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 121 bits (304), Expect = 1e-26
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 3/127 (2%)
Query: 1023 TEQCGL-FSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHG-ECI 1080
T +C + +F C NGRC+P + CDG+ DC D SDE+ C + C + F C G CI
Sbjct: 26 TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCI 85
Query: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
+RC+ DC DGSDE NC T P C +Y C N CI K+++CD N+C D SDE
Sbjct: 86 IGRFRCNGFEDCPDGSDEENC-TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Query: 1141 KNCNSTE 1147
++C S++
Sbjct: 145 ESCESSQ 151
Score = 112 bits (280), Expect = 9e-24
Identities = 58/122 (47%), Positives = 71/122 (58%), Gaps = 10/122 (8%)
Query: 3637 PGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKW 3696
PG F C+NGRCIP AW+CD DC D SDE +EC + C T F C + CI
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGP-TFFPCASGIHCIIGR 88
Query: 3697 AVCNGVDDCRDNSDEQGCEERTCHPV----GDFRCKNHHCIPLRWQCDGQNDCGDNSDEE 3752
CNG +DC D SDE+ C T +P+ + CKN CI + CDGQN+C DNSDEE
Sbjct: 89 FRCNGFEDCPDGSDEENC---TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEE 145
Query: 3753 NC 3754
+C
Sbjct: 146 SC 147
Score = 107 bits (267), Expect = 3e-22
Identities = 50/114 (43%), Positives = 65/114 (57%), Gaps = 3/114 (2%)
Query: 1072 FTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH-QCISKNWVCDT 1130
F C +G CIP W+CD DC D SDE CP A + C T + C + CI + C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPK-AKSKCGPTFFPCASGIHCIIGRFRCNG 93
Query: 1131 DNDCGDGSDEKNCNSTET-CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
DC DGSDE+NC + C ++++C N CID SF+CDG +C D SDE C
Sbjct: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 105 bits (263), Expect = 8e-22
Identities = 55/146 (37%), Positives = 72/146 (49%), Gaps = 11/146 (7%)
Query: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDER 3791
C+ L + Q G+N E P F C N +CIP W CD DC D SDE+
Sbjct: 8 CLLLSSAAESQLLPGNNFTNECNIP-----GNFMCSNGRCIPGAWQCDGLPDCFDKSDEK 62
Query: 3792 DCEMRT--CHPEYFQCTSG-HCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFE 3848
+C C P +F C SG HC+ +C+G DC D SDE +C + C +
Sbjct: 63 ECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTA---NPLLCSTARYH 119
Query: 3849 CKNHVCIPPYWKCDGDDDCGDGSDEE 3874
CKN +CI + CDG ++C D SDEE
Sbjct: 120 CKNGLCIDKSFICDGQNNCQDNSDEE 145
Score = 100 bits (249), Expect = 3e-20
Identities = 49/127 (38%), Positives = 65/127 (51%), Gaps = 5/127 (3%)
Query: 3719 CHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC--APRECTESEFRCVNQ-QCIPSR 3775
C+ G+F C N CIP WQCDG DC D SDE+ C A +C + F C + CI R
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
Query: 3776 WICDHYNDCGDNSDERDCEMR--TCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCP 3833
+ C+ + DC D SDE +C C + C +G C+ CDG +C D SDE C
Sbjct: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
Query: 3834 TRFPDGA 3840
+ G+
Sbjct: 149 SSQEPGS 155
Score = 100 bits (249), Expect = 3e-20
Identities = 52/118 (44%), Positives = 68/118 (57%), Gaps = 5/118 (4%)
Query: 3599 WQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANG-RCIPQAWKCDVD 3657
+ C+N RCIP +WQCD DC D SDE A C P F CA+G CI ++C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 3658 NDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE 3715
DC D SDE E C ++ LC + CK N CI K +C+G ++C+DNSDE+ CE
Sbjct: 95 EDCPDGSDE--ENCTANPLLCST-ARYHCK-NGLCIDKSFICDGQNNCQDNSDEESCE 148
Score = 98.2 bits (243), Expect = 2e-19
Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 6/122 (4%)
Query: 27 ECD-SAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC--AVVTCQQGYFKCQSEGQCIPN 83
EC+ +F C +G CIP W+CDG DC D +DE C A C +F C S CI
Sbjct: 28 ECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
Query: 84 SWVCDQDQDCDDGSDERQDCSQS--TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADEND 141
+ C+ +DC DGSDE ++C+ + CS+ + C NG CI + CD +C D +DE
Sbjct: 88 RFRCNGFEDCPDGSDE-ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 142 CQ 143
C+
Sbjct: 147 CE 148
Score = 96.3 bits (238), Expect = 6e-19
Identities = 48/114 (42%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Query: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQ--FQCSDG-NCTSPQTLCN 3573
F+C+N +CIP W+CDG DC D SDE CP+ + G F C+ G +C + CN
Sbjct: 35 FMCSNG-RCIPGAWQCDGLPDCFDKSDEKE-CPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
Query: 3574 AHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDS 3627
++CPDGSDE+ C + + C N CI +S+ CD N+C+DNSDE+S
Sbjct: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Score = 95.1 bits (235), Expect = 1e-18
Identities = 47/115 (40%), Positives = 64/115 (55%), Gaps = 3/115 (2%)
Query: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECD 1251
F C++G +CI +CDG+ DC D SDE CP + C F C CI + C+
Sbjct: 35 FMCSNG-RCIPGAWQCDGLPDCFDKSDEKECP-KAKSKCGPTFFPCASGIHCIIGRFRCN 92
Query: 1252 GHPDCLYGSDEHNACV-PKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
G DC GSDE N P C ++ +HC NG CI ++++CD N+C D SDE+ C
Sbjct: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 94.7 bits (234), Expect = 2e-18
Identities = 49/127 (38%), Positives = 68/127 (53%), Gaps = 5/127 (3%)
Query: 2779 DCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYT--KCHNSNICI 2836
+CN FMC+N RCIP + C+G+ +C D SDEK CP + G T C + CI
Sbjct: 28 ECNIPGNFMCSNGRCIPGAWQCDGLPDCFDK--SDEKECPKAKSKCGPTFFPCASGIHCI 85
Query: 2837 PRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEP 2896
+ C+G DC D SDE CS++ + C +G CI + + CD + +C D SDE
Sbjct: 86 IGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE- 144
Query: 2897 ASCGHSE 2903
SC S+
Sbjct: 145 ESCESSQ 151
Score = 94.4 bits (233), Expect = 2e-18
Identities = 48/125 (38%), Positives = 67/125 (53%), Gaps = 8/125 (6%)
Query: 140 NDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNG-EC 195
N+C P C NG C + +CD DC D SDE C + C F C +G C
Sbjct: 27 NECNIPG--NFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHC 84
Query: 196 IPRAYVCDHDNDCQDGSDEHAC--NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
I + C+ DC DGSDE C N C ++ C +G CI ++++CDG+++C+DN DE
Sbjct: 85 IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Query: 254 DGCES 258
+ CES
Sbjct: 145 ESCES 149
Score = 93.6 bits (231), Expect = 4e-18
Identities = 51/119 (42%), Positives = 63/119 (52%), Gaps = 8/119 (6%)
Query: 2911 FKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSW 2970
F C GRCIP W CDG DC D SDE + + +++ C + F C + CI +
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK-CGPTFFPCASGI----HCIIGRF 89
Query: 2971 VCDGDVDCTDGYDENQNCTRRT--CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
C+G DC DG DE +NCT CS + C GLCI K F CD N+C D SDE C
Sbjct: 90 RCNGFEDCPDGSDE-ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 92.0 bits (227), Expect = 1e-17
Identities = 52/125 (41%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 1144 NSTETCQ-PSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL---NCTASQFKCASGDK 1199
N T C P F C N RCI ++ CDG DC D SDE C C + F CASG
Sbjct: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
Query: 1200 CIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYG 1259
CI RC+G DC D SDE C T P +C + + C ++G+CI + CDG +C
Sbjct: 84 CIIGRFRCNGFEDCPDGSDEENC-TANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQDN 141
Query: 1260 SDEHN 1264
SDE +
Sbjct: 142 SDEES 146
Score = 92.0 bits (227), Expect = 1e-17
Identities = 49/116 (42%), Positives = 61/116 (52%), Gaps = 11/116 (9%)
Query: 2953 FLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC--TRRTCSENEFTCGYGL-CIPKI 3009
F+C N R CIP +W CDG DC D DE + C + C F C G+ CI
Sbjct: 35 FMCSNGR-----CIPGAWQCDGLPDCFDKSDEKE-CPKAKSKCGPTFFPCASGIHCIIGR 88
Query: 3010 FRCDRHNDCGDYSDERGCLYQT--CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
FRC+ DC D SDE C C ++ C+NG CI K+F+CD N+C D SDE
Sbjct: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 89.4 bits (220), Expect = 8e-17
Identities = 50/122 (40%), Positives = 61/122 (50%), Gaps = 5/122 (4%)
Query: 3847 FECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNN-RCIYSHEVCNG 3905
F C N CIP W+CDG DC D SDE+ C P F C + CI CNG
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCG-PTFFPCASGIHCIIGRFRCNG 93
Query: 3906 VDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKG 3965
+DC DG+DE E+C P C+ Y C NG CI +CD ++C D SDE C
Sbjct: 94 FEDCPDGSDE--ENCTA-NPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
Query: 3966 KE 3967
+E
Sbjct: 151 QE 152
Score = 87.4 bits (215), Expect = 3e-16
Identities = 52/137 (37%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 2809 NNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSE 2868
NN ++E N P G C N CIP + CDG DC D SDE C +
Sbjct: 23 NNFTNECNIP------GNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF 75
Query: 2869 FQCASG-RCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDG 2927
F CASG CI + C+ DC D SDE +C + C + C G CI +ICDG
Sbjct: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEE-NCTANPLLCSTARYHCKNGLCIDKSFICDG 134
Query: 2928 DNDCGDMSDEDKRHQCQ 2944
N+C D SDE+ Q
Sbjct: 135 QNNCQDNSDEESCESSQ 151
Score = 85.5 bits (210), Expect = 1e-15
Identities = 42/112 (37%), Positives = 64/112 (57%), Gaps = 4/112 (3%)
Query: 1235 FQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT-CPSSYFHCDNG-NCIHRAWLCDR 1292
F C +G CIP W+CDG PDC SDE K+ C ++F C +G +CI + C+
Sbjct: 35 FMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
Query: 1293 DNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
DC D SDE++C P C + ++ C + +C++ S +CDG +C + +DE
Sbjct: 94 FEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDE 144
Score = 84.7 bits (208), Expect = 2e-15
Identities = 49/132 (37%), Positives = 64/132 (48%), Gaps = 8/132 (6%)
Query: 178 NCTEIC-LHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT--CGGYQFTCPSG-R 233
N T C + F C NG CIP A+ CD DC D SDE C CG F C SG
Sbjct: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
Query: 234 CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCP 293
CI + C+G +DC D DE+ C + P CS + C ++G CI +CDG +C
Sbjct: 84 CIIGRFRCNGFEDCPDGSDEENCTANPL---LCSTARYHC-KNGLCIDKSFICDGQNNCQ 139
Query: 294 GREDENNTSTGK 305
DE + + +
Sbjct: 140 DNSDEESCESSQ 151
Score = 84.7 bits (208), Expect = 2e-15
Identities = 47/126 (37%), Positives = 59/126 (46%), Gaps = 5/126 (3%)
Query: 2987 NCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG-R 3043
N T F C G CIP ++CD DC D SDE+ C C F C +G
Sbjct: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
Query: 3044 CISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDN 3103
CI F C+ DC DGSDE C C + C NG CI+ +C+ ++C DN
Sbjct: 84 CIIGRFRCNGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDN 141
Query: 3104 SDEKGC 3109
SDE+ C
Sbjct: 142 SDEESC 147
Score = 83.2 bits (204), Expect = 6e-15
Identities = 43/120 (35%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 3556 GQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-RCIPESWQCD 3614
G F CS+G C C+ +C D SDE C + CA+ CI ++C+
Sbjct: 33 GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
Query: 3615 TFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSS 3674
F DC D SDE++ C ++ C NG CI +++ CD N+C D+SDE E C SS
Sbjct: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE--ESCESS 150
Score = 73.2 bits (178), Expect = 6e-12
Identities = 45/132 (34%), Positives = 62/132 (46%), Gaps = 10/132 (7%)
Query: 2646 NQKQQCNNPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASS 2704
N +CN P N CS+ C PG QC + + ++ K C +CG +
Sbjct: 24 NFTNECNIPG---NFMCSNGRCIPGA----WQCDGLPDCFDKSDEKECPKAKS-KCGPTF 75
Query: 2705 FTCSNG-RCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYY 2763
F C++G CI ++C+ DC DGSDE CS + C NG C+ S+ CD
Sbjct: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
Query: 2764 NDCGDGSDEAGC 2775
N+C D SDE C
Sbjct: 136 NNCQDNSDEESC 147
Score = 72.0 bits (175), Expect = 1e-11
Identities = 41/127 (32%), Positives = 59/127 (46%), Gaps = 15/127 (11%)
Query: 990 PVPNFQRVCGCPYGMRLASNHLT-----CEGDPT-------NEPPT--EQCGLFSFPCKN 1035
P NF C P ++ C+G P E P +CG FPC +
Sbjct: 21 PGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCAS 80
Query: 1036 G-RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVD 1094
G C+ + C+G +DC D SDE+ C CS++ + C +G CI + CD +N+C D
Sbjct: 81 GIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQD 140
Query: 1095 GSDEHNC 1101
SDE +C
Sbjct: 141 NSDEESC 147
Score = 68.6 bits (166), Expect = 1e-10
Identities = 37/97 (38%), Positives = 47/97 (48%), Gaps = 4/97 (4%)
Query: 1276 FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGI 1335
F C NG CI AW CD DC D SDEK+CP +C + C C+ C+G
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 1336 FDCPNGTDESPLCNGNS--CSDFNGGCTHE-CVQEPF 1369
DCP+G+DE C N CS C + C+ + F
Sbjct: 95 EDCPDGSDEEN-CTANPLLCSTARYHCKNGLCIDKSF 130
Score = 68.2 bits (165), Expect = 2e-10
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 5/104 (4%)
Query: 22 PASGQECDSAHFRCGSG-HCIPADWRCDGTKDCSDDADEIGCAV--VTCQQGYFKCQSEG 78
P + +C F C SG HCI +RC+G +DC D +DE C + C + C++ G
Sbjct: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKN-G 123
Query: 79 QCIPNSWVCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCI 121
CI S++CD +C D SDE + SQ S S Q +
Sbjct: 124 LCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
Score = 65.1 bits (157), Expect = 2e-09
Identities = 37/93 (39%), Positives = 43/93 (46%), Gaps = 8/93 (8%)
Query: 217 CNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPES 276
CN P F C +GRCI W CDG DC D DE C P KC P + C
Sbjct: 29 CNIPG----NFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC---PKAKSKCGPTFFPCASG 81
Query: 277 GRCISIYKVCDGILDCP-GREDENNTSTGKYCS 308
CI C+G DCP G ++EN T+ CS
Sbjct: 82 IHCIIGRFRCNGFEDCPDGSDEENCTANPLLCS 114
Score = 61.2 bits (147), Expect = 2e-08
Identities = 34/81 (41%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNG-HCI 3941
CN P F C N RCI C+G+ DC D +DE E C K K C + C +G HCI
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPKAKSK-CGPTFFPCASGIHCI 85
Query: 3942 PHDNVCDDADDCGDWSDELGC 3962
C+ +DC D SDE C
Sbjct: 86 IGRFRCNGFEDCPDGSDEENC 106
Score = 59.3 bits (142), Expect = 9e-08
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSD-ELALCPQRFCRLGQFQCSDGNCTSPQT 3570
C T F CA+ CI ++C+G +DC DGSD E C ++ C +G C
Sbjct: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSF 130
Query: 3571 LCNAHQNCPDGSDEDRLLCEN 3591
+C+ NC D SDE+ CE+
Sbjct: 131 ICDGQNNCQDNSDEES--CES 149
Score = 50.4 bits (119), Expect = 4e-05
Identities = 42/131 (32%), Positives = 58/131 (44%), Gaps = 26/131 (19%)
Query: 3077 PHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GINECHDPSISGCDHNCTDTLTSFY 3134
P F C NGRCI C+ L DC D SDEK C ++C P+ C + F
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC-GPTFFPCASGIHCIIGRFR 90
Query: 3135 CSCRPGYKLMSDKRTCVDIDECTEMPFVCS---QKCEN---VIGSYICKCAPGYLREPDG 3188
C+ G++ D D + CT P +CS C+N + S+IC DG
Sbjct: 91 CN---GFEDCPDGS---DEENCTANPLLCSTARYHCKNGLCIDKSFIC----------DG 134
Query: 3189 K-TCRQNSNIE 3198
+ C+ NS+ E
Sbjct: 135 QNNCQDNSDEE 145
Score = 50.1 bits (118), Expect = 5e-05
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 10/81 (12%)
Query: 1000 CPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQL 1059
CP G S+ C +P C + CKNG C+ ++CDG ++C DNSDE+
Sbjct: 97 CPDG----SDEENCTANPL------LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 1060 CGTLNNTCSSSAFTCGHGECI 1080
C + S F + +
Sbjct: 147 CESSQEPGSGQVFVTSENQLV 167
Score = 42.4 bits (98), Expect = 0.011
Identities = 26/107 (24%), Positives = 42/107 (39%), Gaps = 6/107 (5%)
Query: 2655 CEQFNGGCSHICAPGPNGAEC-----QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSN 2709
C + C P +G C +C + ++ ++C N C + + C N
Sbjct: 64 CPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTA-NPLLCSTARYHCKN 122
Query: 2710 GRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY 2756
G CI + + CD N+C D SDE + S F + + V Y
Sbjct: 123 GLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYY 169
Score = 40.8 bits (94), Expect = 0.032
Identities = 38/132 (28%), Positives = 46/132 (34%), Gaps = 23/132 (17%)
Query: 3933 YKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKER------TCAENICEQNCTQLNEGG 3986
+ C NG CIP CD DC D SDE C K K + CA I +C G
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGI---HCI---IGR 88
Query: 3987 FICSCTAGFETNVFDRTSCLDINECEQ----FGTCPQHCRNTKGSYECVCADGFTSMSDR 4042
F C+ GFE D D C T HC+N + DG + D
Sbjct: 89 FRCN---GFE----DCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDN 141
Query: 4043 PGKRCAAEGSSP 4054
+ P
Sbjct: 142 SDEESCESSQEP 153
Score = 35.4 bits (80), Expect = 1.3
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 8/85 (9%)
Query: 3463 PIVSNPCGTNNGGCS---HLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLC 3519
P + CG C+ H + + GF +CPD + + +CS+ ++ C
Sbjct: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFE-DCPDGSDEENCTANPL---LCSTARYHC 120
Query: 3520 ANNEKCIPIWWKCDGQKDCSDGSDE 3544
N CI + CDGQ +C D SDE
Sbjct: 121 KNG-LCIDKSFICDGQNNCQDNSDE 144
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 119 bits (298), Expect = 7e-26
Identities = 130/502 (25%), Positives = 195/502 (38%), Gaps = 97/502 (19%)
Query: 1000 CPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRC--VPNYYLCDGVDDCHDNSDE 1057
CP G A+ +T G P + E C + C +G+C + C +S+E
Sbjct: 1008 CPRGPGFATKEIT-NGKPFFKDINE-CKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEE 1065
Query: 1058 QLCGTLNNTCSSSAFTCGHGECI--PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYT 1115
+ C ++ C S CG G+C+ P + C C +G + +C+D
Sbjct: 1066 RNCTDIDE-CRISPDLCGRGQCVNTPGDFECK----CDEG---YESGFMMMKNCMDID-E 1116
Query: 1116 CDNHQCISKNWVCDTDN-----DCGDGS----DEKNCNSTETCQPSQFNCPNHRCIDL-- 1164
C + + VC +C G + C C+ S CPN RC++L
Sbjct: 1117 CQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIG 1176
Query: 1165 SFVCDGDKD---------CVDGSD----EVGCVLNCTASQ----FKCASGDKCIGVTNRC 1207
+ C + CVD + GC CT S+ C G + C
Sbjct: 1177 KYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSC 1236
Query: 1208 DGVFDCSDNSD--EAGCPTRPPG----MCHSDEFQCQEDGICIPNFWECDGHPD-CLYGS 1260
+ +C DN + + G T PG +C+ D F ED + ECD +P+ CL G+
Sbjct: 1237 TDIDECEDNPNICDGGQCTNIPGEYRCLCY-DGFMASEDMKTCVDVNECDLNPNICLSGT 1295
Query: 1261 DEHNACVPKTCPSSYFHCDNG--------------NCIHRAWLCDRDNDCGDMSDEKDCP 1306
E+ T S HCD G C A C + C + + C
Sbjct: 1296 CEN------TKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCS 1349
Query: 1307 TQPFRCPSWQW---QCLGHNICVNLSVVCDGIFDCPNGTDESPLC--------NGNSCSD 1355
P W +C + C N + +C DC N T S C +G +C+D
Sbjct: 1350 CSP----GWIGDGIKCTDLDECSNGTHMCSQHADCKN-TMGSYRCLCKEGYTGDGFTCTD 1404
Query: 1356 FNGGCTH--------ECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC-SQHCYN 1406
+ C+ +C+ P G +C C +GF+ + D K CEDIDEC + C C+N
Sbjct: 1405 LDE-CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHN 1463
Query: 1407 MRGSFRCSCDTGYMLESDGRTC 1428
+ G FRC C+ GY L+ G C
Sbjct: 1464 LPGLFRCECEIGYELDRSGGNC 1485
Score = 117 bits (292), Expect = 3e-25
Identities = 165/730 (22%), Positives = 248/730 (33%), Gaps = 217/730 (29%)
Query: 2653 NPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGR 2711
N C+ C+H C +C+C + + L + ++C + + C S C G+
Sbjct: 1030 NECKMIPSLCTHGKCRNTIGSFKCRC--DSGFALDSEERNCT--DIDECRISPDLCGRGQ 1085
Query: 2712 CISE--EWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRC--VQYSYRCDYYNDCG 2767
C++ +++C D G M++ + C C G C + SYRC+
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQ 1145
Query: 2768 DGSDEAGCL-FRDCNATTEFMCNNRRCI-----------------PREFICNGVDNCHDN 2809
+ + C+ +C + +C N RC+ P C +D C
Sbjct: 1146 LSPNISACIDINECELSAH-LCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIM 1204
Query: 2810 NTSDEKNCPDR------TCQSGYT------------KCH-NSNIC-------IPRVYLC- 2842
N E C + +CQ G+ +C N NIC IP Y C
Sbjct: 1205 NGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCL 1264
Query: 2843 --------DGDNDCGD--NSDENPTYCTTHTCSSSE--FQCASGRCIPQHWYCDQ----- 2885
+ C D D NP C + TC +++ F C +CD
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFIC----------HCDMGYSGK 1314
Query: 2886 --ETDCFDASD---EPASCG-HSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK 2939
+T C D ++ +CG H+ T A FKC C P WI DG C D+ +
Sbjct: 1315 KGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCS---CSPG-WIGDGIK-CTDLDE--- 1366
Query: 2940 RHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFT 2999
C N S+ + RC+ + CTD DE CSEN
Sbjct: 1367 ---CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTD-LDE--------CSENLNL 1414
Query: 3000 CGYGLCI--PKIFRCDRH------------NDCGDYSDERGCLYQTCQQ----------- 3034
CG G C+ P +RC+ D + S C++ TC
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEI 1474
Query: 3035 ------------------NQFTCQNGRCISK--TFVCDE--------------------- 3053
+ TC +G C++ +++CD
Sbjct: 1475 GYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNC 1534
Query: 3054 ---------------DNDCGDGSDELMHLCH------TPEPTCPP-----HEFKCDNGRC 3087
N+ G G + C TP CP ++ C G
Sbjct: 1535 YLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEG 1594
Query: 3088 IEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDK 3147
+ L+D I+EC + C +T SF C C GY L D
Sbjct: 1595 FRPNPITVILED-----------IDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDT 1643
Query: 3148 RTCVDIDECTEMPFVCSQ-KCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNR 3206
R C D++EC E P +C C N +G+Y C C P Y++ G C ++ L + N
Sbjct: 1644 RVCDDVNEC-ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNC---MDMRRSLCYRN- 1698
Query: 3207 YYLRNLTIDG 3216
YY N T DG
Sbjct: 1699 YYADNQTCDG 1708
Score = 108 bits (270), Expect = 1e-22
Identities = 172/670 (25%), Positives = 251/670 (37%), Gaps = 165/670 (24%)
Query: 3443 TLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQL 3502
TL + F I +Y P+ + C G C + I G F CECP F
Sbjct: 1746 TLCGSQRPGFVIDIYTGL--PVDIDECREIPGVCENGVCINMVGS-FRCECPVGFFYNDK 1802
Query: 3503 SGSTYCMPMCSSTQFLCANNEKCIPIW--WKCDGQKDCSDGSDELALCPQRFCRLGQFQC 3560
+ C + +C N +CI ++CD C G RF GQ C
Sbjct: 1803 LLVCEDIDECQNGP-VCQRNAECINTAGSYRCD----CKPG--------YRFTSTGQ--C 1847
Query: 3561 SDGN-CTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
+D N C +C+ H C D LC +++ C N+C
Sbjct: 1848 NDRNECQEIPNICS-HGQCIDTVGSFYCLCHTGFKTNDD-----------QTMCLDINEC 1895
Query: 3620 EDNSDEDSSHCASRTCRP--GQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMS-SAH 3676
E ++ C + TCR G F C RC + +NDC D ++EC S + +
Sbjct: 1896 ERDA------CGNGTCRNTIGSFNC---RC-NHGFILSHNNDCID-----VDECASGNGN 1940
Query: 3677 LCDN------FTEFSCKTN--YRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPV-GDFRC 3727
LC N F C+ N Y P C +++C + + C TC + G +RC
Sbjct: 1941 LCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECL--LEPRKCAPGTCQNLDGSYRC 1998
Query: 3728 KNHHCIP----LRWQCDGQNDCGDNSDEENCAPREC--TESEFRCVNQQCIPSRWICDHY 3781
C P +C+ ++C + + E CA C TE F+C+ C +
Sbjct: 1999 I---CPPGYSLQNEKCEDIDECVE--EPEICALGTCSNTEGSFKCL---CPEGFSLSSSG 2050
Query: 3782 NDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDA------SDEAD-CPT 3834
C +D M C+ ++ G C + + +C A D + CPT
Sbjct: 2051 RRC------QDLRMSYCYAKF---EGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPT 2101
Query: 3835 RFPDGAYCQATMFECKNHVCIPPYWK--CDGDDDCGDGSDE--ELHLCLDVPC-NSPNRF 3889
PD A+ Q I PY G DD DE E +C C N+ +
Sbjct: 2102 E-PDEAFRQ-----------ICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSY 2149
Query: 3890 RCD--------NNRCIYSHEVCNGVDDCGDGTDE--------TEEHCRKPTPKPCTE--- 3930
RC+ N C+ + E C+ + CG+GT + T E +P P E
Sbjct: 2150 RCECPFGYILAGNECVDTDE-CSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDIN 2208
Query: 3931 -------------------YEYKCGNGHCIPHDN-VCDDADDCGDWSDELGCNKGKERTC 3970
YE KC G+ + D +C D D+C +GK C
Sbjct: 2209 ECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDEC---------EEGKH-DC 2258
Query: 3971 AENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECE-QFGTCPQ-HCRNTKGSY 4028
E + C L G ++C C G++ D C+D NEC+ + G C C NT+GSY
Sbjct: 2259 TEK--QMECKNLI-GTYMCICGPGYQRRP-DGEGCVDENECQTKPGICENGRCLNTRGSY 2314
Query: 4029 ECVCADGFTS 4038
C C DGFT+
Sbjct: 2315 TCECNDGFTA 2324
Score = 102 bits (255), Expect = 7e-21
Identities = 156/632 (24%), Positives = 222/632 (35%), Gaps = 137/632 (21%)
Query: 3489 FTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALC 3548
+TC CP D+ +Q++G CM M S LC N CDG+ + + ++ C
Sbjct: 1670 YTCICPPDY--MQVNGGNNCMDMRRS---LCYRNYYADN--QTCDGEL-LFNMTKKMCCC 1721
Query: 3549 PQRFCRLGQFQCSDGNCTSPQT-----LCNAHQ---------NCPDGSDEDRLL---CEN 3591
R C C P T LC + + P DE R + CEN
Sbjct: 1722 SYNIGRAWNKPCEQ--CPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCEN 1779
Query: 3592 HHCDS--NEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCR----PGQFRCANG 3645
C + ++C C + D CED + + R G +RC
Sbjct: 1780 GVCINMVGSFRC---ECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCD-- 1834
Query: 3646 RCIPQAWKCDVDNDCGDHSD-EPIEECMSSAHLCDNFTEFSC--KTNYRCIPKWAVCNGV 3702
C P ++ C D ++ + I S D F C T ++ +C +
Sbjct: 1835 -CKP-GYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDI 1892
Query: 3703 DDCRDNSDEQGCEERTC-HPVGDFRCKNHHCIPLRWQCDGQNDCGD-----NSDEENCAP 3756
++C + C TC + +G F C+ +H L NDC D + + C
Sbjct: 1893 NEC----ERDACGNGTCRNTIGSFNCRCNHGFIL----SHNNDCIDVDECASGNGNLCRN 1944
Query: 3757 REC--TESEFRCV---NQQCIPSRWICDHYNDCGDNSDERDCEMRTCH----PEYFQCTS 3807
+C T F+C + P C N+C + R C TC C
Sbjct: 1945 GQCINTVGSFQCQCNEGYEVAPDGRTCVDINEC--LLEPRKCAPGTCQNLDGSYRCICPP 2002
Query: 3808 GHCVHSELKCDGSADCLD--------------ASDEADCPTRFP---DGAYCQ-ATMFEC 3849
G+ + +E KC+ +C++ S + CP F G CQ M C
Sbjct: 2003 GYSLQNE-KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYC 2061
Query: 3850 ----KNHVCIPPYWKCDGDDDC-----GDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH 3900
+ C P + +C G+G + LC P FR C Y
Sbjct: 2062 YAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELC---PTEPDEAFR---QICPYGS 2115
Query: 3901 EVCNGVDDCGDGTDETEEHCRKPTPKPCTE---------YEYKCGNGHCIPHDNVCDDAD 3951
+ G DD DE +E P C Y +C G+ + N C D D
Sbjct: 2116 GIIVGPDDSAVDMDECKE------PDVCKHGQCINTDGSYRCECPFGYILA-GNECVDTD 2168
Query: 3952 DCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC 4011
+C + C G TC I GGF C+C GFE +C DINEC
Sbjct: 2169 ECSVGNP---CGNG---TCKNVI----------GGFECTCEEGFEPGPM--MTCEDINEC 2210
Query: 4012 EQFGT-CPQHCRNTKGSYECVCADGFTSMSDR 4042
Q C C NT GSYEC C G+ DR
Sbjct: 2211 AQNPLLCAFRCVNTYGSYECKCPVGYVLREDR 2242
Score = 97.1 bits (240), Expect = 4e-19
Identities = 110/437 (25%), Positives = 156/437 (35%), Gaps = 53/437 (12%)
Query: 1017 PTNEPP-------TEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSS 1069
P+ EPP T+ C L + C+NGRC+P C +C+ L G +
Sbjct: 437 PSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCR--CECNKGFQLDLRGECIDVDEC 494
Query: 1070 SAFTCGHGECI--PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISK--N 1125
C GECI + C R C CL C+N +CI+ +
Sbjct: 495 EKNPCAGGECINNQGSYTCQCRAGYQSTLTRTEC--RDIDECLQNGRICNNGRCINTDGS 552
Query: 1126 WVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCI--DLSFVCDGDKDCVDGSDEVGC 1183
+ C + D KNC + C C N CI D SF C SD C
Sbjct: 553 FHCVCNAGFHVTRDGKNCEDMDECSIRNM-CLNGMCINEDGSFKCICKPGFQLASDGRYC 611
Query: 1184 V-LNCTASQFKCASGDKCIGV--TNRCDGVFDCSDNSDEAGC-PTRPPGMCHSDEFQCQE 1239
+N + C +G +C+ + RC+ + D C T C+ +
Sbjct: 612 KDINECETPGICMNG-RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGG----YK 666
Query: 1240 DGICIPNFWECDGHPDCLYGSDEHNACVP-KTCPSSYFHCDNGNCIHRAWLCDRDNDCGD 1298
G CI + +C S E+ P + CP+ + ++A
Sbjct: 667 RGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPA------QNSAEYQALCSSGPGMTSA 720
Query: 1299 MSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNG 1358
SD +C P CP + IC NL G + C + G +C D N
Sbjct: 721 GSDINECALDPDICP--------NGICENLR----GTYKCICNSGYEVDSTGKNCVDINE 768
Query: 1359 GCTH-------ECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSF 1411
+ +C P C CP GF+ D KTCEDIDEC+ + C N GSF
Sbjct: 769 CVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSF 828
Query: 1412 RCSCDTGYMLESDGRTC 1428
C C + L+ C
Sbjct: 829 ICECSSESTLDPTKTIC 845
Score = 96.3 bits (238), Expect = 6e-19
Identities = 151/642 (23%), Positives = 211/642 (32%), Gaps = 121/642 (18%)
Query: 2650 QCNNPCEQFNGGC-----SHIC------APGPNGAECQCPH-EGNWYLANNRKHCI---- 2693
+C P NG C S+ C A G +G C H Y R CI
Sbjct: 616 ECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLF 675
Query: 2694 --VDNGERCGASSFTCSNGRCISEEWKCDNDND------CGDGSDEMESVCALHTCSPTA 2745
V E C AS+ C C N C G + ++ C+
Sbjct: 676 GAVTKSECCCASTEYAFGEPC----QPCPAQNSAEYQALCSSGPGMTSAGSDINECALDP 731
Query: 2746 FTCANGRC--VQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRC--IPREFICN 2801
C NG C ++ +Y+C + S C+ + +C+N +C P F+C
Sbjct: 732 DICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCT 791
Query: 2802 ---GVDNCHDNNTSDE-KNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPT 2857
G D T ++ C C +G C NS P ++C+ ++ D T
Sbjct: 792 CPKGFIYKPDLKTCEDIDECESSPCINGV--CKNS----PGSFICECSSE--STLDPTKT 843
Query: 2858 YCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGR 2917
C + GRC ++ C S A+ G C D C G
Sbjct: 844 ICIETIKGTCWQTVIDGRCEININGATLKSQC--CSSLGAAWGSPCTLCQVDPI-CGKGY 900
Query: 2918 CIPSEWICDGDNDCGDMSDEDKRHQCQNQN-------------------CSDSEFLCVND 2958
C+ ++C K C N C D
Sbjct: 901 SRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFL 960
Query: 2959 RPPDRRC-IPQSW-----VCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRC 3012
R D C +P + C V G +E + C R E E C G P
Sbjct: 961 RYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRG---PGFATK 1017
Query: 3013 DRHNDCGDYSDERGCLYQTCQQNQFTCQNG------RCISKTFVCDEDNDCGDGSDELM- 3065
+ N + D C C+N RC S + E+ +C D DE
Sbjct: 1018 EITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTD-IDECRI 1076
Query: 3066 --HLCHTPEPTCPPHEF--KCDNG--RCIEMMKLCNHLDDCLDNSDEKGCGINECHD--- 3116
LC + P +F KCD G MMK C +D+C D C CH+
Sbjct: 1077 SPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDEC--QRDPLLCRGGVCHNTEG 1134
Query: 3117 -------------PSISGC--------------DHNCTDTLTSFYCSCRPGYKLMSDKRT 3149
P+IS C + C + + + C+C PGY D+
Sbjct: 1135 SYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLF 1194
Query: 3150 CVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTC 3191
CVDIDEC+ M C C N GSY C C PG+ PD ++C
Sbjct: 1195 CVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSC 1236
Score = 95.9 bits (237), Expect = 8e-19
Identities = 134/593 (22%), Positives = 196/593 (33%), Gaps = 159/593 (26%)
Query: 2655 CEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCI 2713
C + G C + +C C+CP G +Y N K + ++ + C N CI
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECP-VGFFY---NDKLLVCEDIDECQNGPVCQRNAECI 1825
Query: 2714 SE--EWKCD--------NDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY--SYRCD 2761
+ ++CD + C D ++ C C++G+C+ S+ C
Sbjct: 1826 NTAGSYRCDCKPGYRFTSTGQCNDRNE----------CQEIPNICSHGQCIDTVGSFYCL 1875
Query: 2762 YYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT 2821
+ D+ CL D N C N C NT NC
Sbjct: 1876 CHTGFKTNDDQTMCL--DINECERDACGNGTC---------------RNTIGSFNC---R 1915
Query: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSS--EFQCASGRCIPQ 2879
C G+ HN N CI D + + N C C ++ FQC +C
Sbjct: 1916 CNHGFILSHN-NDCI----------DVDECASGNGNLCRNGQCINTVGSFQC---QCNEG 1961
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK 2939
+ C D ++ CL + KC G C DG C
Sbjct: 1962 YEVAPDGRTCVDINE-----------CLLEPRKCAPGTCQN----LDGSYRCICPPG--- 2003
Query: 2940 RHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENE-- 2997
+ QN+ C D + C+ +E + C TCS E
Sbjct: 2004 -YSLQNEKCEDID-----------ECV----------------EEPEICALGTCSNTEGS 2035
Query: 2998 FTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDC 3057
F C LC P+ F S R C + G+C S +C
Sbjct: 2036 FKC---LC-PEGFSLS--------SSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQEC 2083
Query: 3058 -----GDGSDELMHLCHTPEPT------CP--------PHEFKCDNGRCIEMMKLCNHLD 3098
G+G + LC T EP CP P + D C E +C H
Sbjct: 2084 CCALKGEGWGDPCELCPT-EPDEAFRQICPYGSGIIVGPDDSAVDMDECKEP-DVCKH-G 2140
Query: 3099 DCLDNSDEKGCGI--------NECHDPSISGCDH-----NCTDTLTSFYCSCRPGYKLMS 3145
C++ C NEC D + C + + F C+C G++
Sbjct: 2141 QCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFE-PG 2199
Query: 3146 DKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
TC DI+EC + P +C+ +C N GSY CKC GY+ D + C+ E
Sbjct: 2200 PMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECE 2252
Score = 95.9 bits (237), Expect = 8e-19
Identities = 163/719 (22%), Positives = 232/719 (32%), Gaps = 201/719 (27%)
Query: 2650 QCN--NPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCI-VDNGERCGASSF 2705
QCN N C++ CSH C C C H G + +++ C+ ++ ER +
Sbjct: 1846 QCNDRNECQEIPNICSHGQCIDTVGSFYCLC-HTG-FKTNDDQTMCLDINECERDACGNG 1903
Query: 2706 TCSNG------RCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY--S 2757
TC N RC + + ++NDC D + CA S C NG+C+ S
Sbjct: 1904 TCRNTIGSFNCRC-NHGFILSHNNDCIDVDE-----CA----SGNGNLCRNGQCINTVGS 1953
Query: 2758 YRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIP--------------------RE 2797
++C C +G + A R C E + R+C P +
Sbjct: 1954 FQCQ----CNEGYEVAPD-GRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQN 2008
Query: 2798 FICNGVDNCHD----------NNT---------------SDEKNCPDRTCQSGYTKCHNS 2832
C +D C + +NT S + C D Y K
Sbjct: 2009 EKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGG 2068
Query: 2833 NICIPRVYLCDGDNDC----GDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETD 2888
P+ C G+ + C T + C G I D
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVG--PDDSAV 2126
Query: 2889 CFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNC 2948
D EP C H + ++C+ P +I G N+C D + + C N C
Sbjct: 2127 DMDECKEPDVCKHGQCINTDGSYRCE----CPFGYILAG-NECVDTDECSVGNPCGNGTC 2181
Query: 2949 SDS----EFLCVNDRPPD--------RRCIPQSWVC---------DGDVDCTDGYDENQN 2987
+ E C P C +C + C GY ++
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLRED 2241
Query: 2988 CTRRTCS-ENEFTCGYGLCIPKIFRCDRHNDCGDYS-----------DERGCLYQT-CQQ 3034
RR C E+E G C K C N G Y D GC+ + CQ
Sbjct: 2242 --RRMCKDEDECEEGKHDCTEKQMECK--NLIGTYMCICGPGYQRRPDGEGCVDENECQT 2297
Query: 3035 NQFTCQNGRCI----SKTFVCDEDNDCGDGSDE-------------LMHLCHTPEPTCPP 3077
C+NGRC+ S T C++ DE L ++C P
Sbjct: 2298 KPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNP 2357
Query: 3078 ---HEFKCDNGR-------------CIEMMKLCNH----------LDDCLDNSDEKGCGI 3111
E CD GR + KLC H +D+C D C
Sbjct: 2358 VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDV--CRN 2415
Query: 3112 NEC--------------HDPSISG---------------CDHNCTDTLTSFYCSCRPGYK 3142
EC + P I+G C+ C +T S+ CSC GY
Sbjct: 2416 GECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYI 2475
Query: 3143 LMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREP----DGKTCRQNSNI 3197
L D R+C D+DEC C C N IG + CKC PG+ + D C + N+
Sbjct: 2476 LQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINL 2534
Score = 92.0 bits (227), Expect = 1e-17
Identities = 106/404 (26%), Positives = 146/404 (36%), Gaps = 71/404 (17%)
Query: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIP-QH 2880
CQ C N CIP C + + G D C + CA G CI Q
Sbjct: 453 CQLVRYLCQNGR-CIPTPGSCRCECNKGFQLDLRGECIDVDECEKNP--CAGGECINNQG 509
Query: 2881 WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW----IC--------DGD 2928
Y Q + ++ C + CL + C+ GRCI ++ +C DG
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDE-CLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGK 568
Query: 2929 NDCGDMSDEDKRHQCQNQNC--SDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD--- 2983
N C DM + R+ C N C D F C+ C G+
Sbjct: 569 N-CEDMDECSIRNMCLNGMCINEDGSFKCI---------------------CKPGFQLAS 606
Query: 2984 ENQNCTRRTCSENEFTCGYGLCIPK--IFRCDRHNDCGDYSDERGC----LYQTCQQNQF 3037
+ + C E C G C+ +RC+ D R C + TC
Sbjct: 607 DGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGY- 665
Query: 3038 TCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHL 3097
+ G+CI F ++C S E EP C P C E LC+
Sbjct: 666 --KRGQCIKPLFGAVTKSECCCASTEYAF----GEP-CQP----CPAQNSAEYQALCSSG 714
Query: 3098 DDCLDNSDEKGCGINECH-DPSISGCDHNCTDTLTSFY-CSCRPGYKLMSDKRTCVDIDE 3155
G INEC DP I C + + L Y C C GY++ S + CVDI+E
Sbjct: 715 P----GMTSAGSDINECALDPDI--CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINE 768
Query: 3156 CTEMPFVCSQ-KCENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
C +C +C N GS++C C G++ +PD KTC E
Sbjct: 769 CVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECE 812
Score = 90.5 bits (223), Expect = 3e-17
Identities = 143/606 (23%), Positives = 200/606 (33%), Gaps = 141/606 (23%)
Query: 2641 NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPH----------EGNWYLANNRK 2690
N V + NPC NG C ++ G EC C E A N
Sbjct: 2162 NECVDTDECSVGNPCG--NGTCKNVIG----GFECTCEEGFEPGPMMTCEDINECAQNPL 2215
Query: 2691 HCIVDNGERCGASSFTCSNGRCISEEWK-CDNDNDCGDGSDEMESVCALHTCSPTAFTCA 2749
C G+ C G + E+ + C ++++C +G H C+ C
Sbjct: 2216 LCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGK---------HDCTEKQMECK 2266
Query: 2750 NGRCVQYSYRCDYYNDCGDG----SDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDN 2805
N + +Y C CG G D GC+ + T +C N RC+
Sbjct: 2267 N---LIGTYMCI----CGPGYQRRPDGEGCVDENECQTKPGICENGRCL----------- 2308
Query: 2806 CHDNNTSDEKNCPDRTCQSGYTKCHNSNICIP-RVYLCDGD---NDCG-DNSDENPTYCT 2860
NT C C G+T N + C+ R C + N C +S+ NP
Sbjct: 2309 ----NTRGSYTCE---CNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPV--- 2358
Query: 2861 THTCSSSEFQCASGRCIPQHWYCD----QETDCFDASDEPASCGHSERTCLADEFK---- 2912
+ SE C GR H C+ Q T F P G DE K
Sbjct: 2359 ----TKSECCCDGGRGWGPH--CEICPFQGTVAFKKLC-PHGRGFMTNGADIDECKVIHD 2411
Query: 2913 -CDGGRCIPSEW----ICDGD-------NDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRP 2960
C G C+ IC C D+++ C NQ F+C N
Sbjct: 2412 VCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNE------C-NQAPKPCNFICKNTEG 2464
Query: 2961 PDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKI--FRC------ 3012
+ P+ ++ D DE C+ + C + LC+ I F C
Sbjct: 2465 SYQCSCPKGYILQEDGRSCKDLDE--------CATKQHNCQF-LCVNTIGGFTCKCPPGF 2515
Query: 3013 -DRHNDCGDYSD---------ERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSD 3062
H C D ++ +G T CQ G + +T ED D +G+
Sbjct: 2516 TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNH 2575
Query: 3063 ELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGC 3122
H C + C G + C+D NEC I G
Sbjct: 2576 RCQHGCQN---IIGGYRCSCPQGYLQHYQ-----WNQCVDE--------NECLSAHICG- 2618
Query: 3123 DHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGY 3182
+C +TL S+ C C G++ C DI+EC CS C N G Y+C C PGY
Sbjct: 2619 GASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Query: 3183 LREPDG 3188
R G
Sbjct: 2679 FRIGQG 2684
Score = 87.4 bits (215), Expect = 3e-16
Identities = 161/679 (23%), Positives = 239/679 (35%), Gaps = 190/679 (27%)
Query: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGS---------DELAL----CPQRFCR--LG 3556
C+ST++ + P + Q CS G +E AL CP C G
Sbjct: 685 CASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRG 744
Query: 3557 QFQCSDGNCTSPQTLCNAHQNCPDGSD--EDRLLCENHHCDSNEWQCANKRCIPESWQCD 3614
++C C S + + +NC D ++ + LLC+N C R P S+ C
Sbjct: 745 TYKCI---CNSGYEVDSTGKNCVDINECVLNSLLCDNGQC----------RNTPGSFVCT 791
Query: 3615 T---------FNDCEDNSDEDSSHCASRTCR--PGQFRCA-------------------- 3643
CED + +SS C + C+ PG F C
Sbjct: 792 CPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKG 851
Query: 3644 -------NGRC----------------IPQAWK-----CDVDNDCGDHSD-------EPI 3668
+GRC + AW C VD CG E I
Sbjct: 852 TCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDI 911
Query: 3669 EECMSSAHLCDNFTEFSCKTNYRC-IPKWAVCNGVDDCRDNSDEQGC------EERTCHP 3721
+EC +C N + + +++C P + + + C EE T
Sbjct: 912 DECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPI 971
Query: 3722 VGDFRCKNHHC-IPLRWQCDGQNDCGDNSD---EENC------APRECTESE--FRCVNQ 3769
G R C + W + +C + EE C A +E T + F+ +N+
Sbjct: 972 AGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINE 1031
Query: 3770 -QCIPSRWICDH---YNDCGD-----------NSDERDC-EMRTCHPEYFQCTSGHCVHS 3813
+ IPS +C H N G +S+ER+C ++ C C G CV++
Sbjct: 1032 CKMIPS--LCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNT 1089
Query: 3814 ----ELKCDGSAD--------CLDASDEADCPTRFPDGAYCQAT--MFECKNHVCIPPYW 3859
E KCD + C+D DE G C T + C+ C P +
Sbjct: 1090 PGDFECKCDEGYESGFMMMKNCMDI-DECQRDPLLCRGGVCHNTEGSYRCE---CPPGHQ 1145
Query: 3860 KCDGDDDCGDGSDEEL--HLCLDVPC-NSPNRFRCDNNRCIYSHE---VCNGVDDCGDGT 3913
C D ++ EL HLC + C N +++C N +S C +D+C
Sbjct: 1146 LSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMN 1205
Query: 3914 DETEEHCRKPTPKPCTEYEYKCGNGHCI-PHDNVCDDADDCGDWSDELGCNKGKERTCAE 3972
E C YE C G + P C D D+C D
Sbjct: 1206 GGCETFCTNSEGS----YECSCQPGFALMPDQRSCTDIDECED---------------NP 1246
Query: 3973 NICEQN-CTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQ------FGTCPQHCRNTK 4025
NIC+ CT + G + C C GF + D +C+D+NEC+ GTC NTK
Sbjct: 1247 NICDGGQCTNI-PGEYRCLCYDGFMASE-DMKTCVDVNECDLNPNICLSGTC----ENTK 1300
Query: 4026 GSYECVCADGFTSMSDRPG 4044
GS+ C C G++ + G
Sbjct: 1301 GSFICHCDMGYSGKKGKTG 1319
Score = 87.4 bits (215), Expect = 3e-16
Identities = 113/479 (23%), Positives = 170/479 (35%), Gaps = 97/479 (20%)
Query: 982 GDCSHFCFPVPN--FQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCV 1039
GD C P+ F+++C G+ + + + D EP CK+G+C+
Sbjct: 2093 GDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDV---------CKHGQCI 2143
Query: 1040 ----------PNYYLCDGVDDCHDNSDEQL---CG--TLNNTCSSSAFTCGHGECIPAHW 1084
P Y+ G ++C D + + CG T N TC G
Sbjct: 2144 NTDGSYRCECPFGYILAG-NECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMM 2202
Query: 1085 RCDKRNDCVDGSDEHNCPTHAPASCLDT--QYTCD---NHQCISKNWVCDTDNDCGDGSD 1139
C+ N+C P C++T Y C + +C +++C +G
Sbjct: 2203 TCEDINECAQN------PLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKH 2256
Query: 1140 EKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCV--LNCTASQFKCASG 1197
+ C Q C N + +++C D GCV C C +G
Sbjct: 2257 D--------CTEKQMECKN---LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENG 2305
Query: 1198 DKCIGV----TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH 1253
+C+ T C+ F S N DE C G C ++ Q
Sbjct: 2306 -RCLNTRGSYTCECNDGFTASPNQDE--CLDNREGYCFTEVLQNM--------------- 2347
Query: 1254 PDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAW--LCDRDNDCGDMSDEKDCPT-QPF 1310
C GS N C CD G R W C+ G ++ +K CP + F
Sbjct: 2348 --CQIGSSNRNPVTKSECC-----CDGG----RGWGPHCEICPFQGTVAFKKLCPHGRGF 2396
Query: 1311 RCPSWQW-QC-LGHNICVNLSVVCD-GIFDCPNGTDESPLCNGNSCSDFNG------GCT 1361
+C + H++C N V D G + C T +P G SC D N C
Sbjct: 2397 MTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCN 2456
Query: 1362 HECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDI-LGSCSQHCYNMRGSFRCSCDTGY 1419
C +C CP G++L D ++C+D+DEC +C C N G F C C G+
Sbjct: 2457 FICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF 2515
Score = 86.3 bits (212), Expect = 7e-16
Identities = 121/496 (24%), Positives = 177/496 (35%), Gaps = 136/496 (27%)
Query: 998 CGCPYGMRLASNHLTCEGDPTNEPPTEQ-CG-------LFSFPCKNGRCVPNYYLCDGVD 1049
C CP G L + C D NE T CG + ++ C C P+Y +G +
Sbjct: 1631 CRCPTGYYLNEDTRVC--DDVNECETPGICGPGTCYNTVGNYTCI---CPPDYMQVNGGN 1685
Query: 1050 DCHDN----------SDEQLC-GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
+C D +D Q C G L + C + I W + +DE
Sbjct: 1686 NCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYN--IGRAWNKPCEQCPIPSTDE 1743
Query: 1099 HN--CPTHAPA--------------SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKN 1142
C + P C + C+N CI N V +C G +
Sbjct: 1744 FATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCI--NMVGSFRCECPVGFFYND 1801
Query: 1143 ----CNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCT-----ASQFK 1193
C + CQ N P VC + +C++ + C +C S +
Sbjct: 1802 KLLVCEDIDECQ----NGP---------VCQRNAECINTAGSYRC--DCKPGYRFTSTGQ 1846
Query: 1194 CASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH 1253
C ++C + N C C D C +CH+ F+ +D + EC
Sbjct: 1847 CNDRNECQEIPNICSHG-QCIDTVGSFYC------LCHTG-FKTNDDQTMCLDINEC--- 1895
Query: 1254 PDCLYGSDEHNACVPKTCPSSY--FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR 1311
E +AC TC ++ F+C C H ++ +NDC D+ +
Sbjct: 1896 --------ERDACGNGTCRNTIGSFNC---RCNH-GFILSHNNDCIDVDE---------- 1933
Query: 1312 CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGA 1371
C S + C+N G F C +G +C D N EC+ EP
Sbjct: 1934 CASGNGNLCRNGQCINTV----GSFQCQCNEGYEVAPDGRTCVDIN-----ECLLEPRKC 1984
Query: 1372 ------------KCLCPLGFLLANDSKTCEDIDECD------ILGSCSQHCYNMRGSFRC 1413
+C+CP G+ L N+ CEDIDEC LG+CS N GSF+C
Sbjct: 1985 APGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTCS----NTEGSFKC 2038
Query: 1414 SCDTGYMLESDGRTCK 1429
C G+ L S GR C+
Sbjct: 2039 LCPEGFSLSSSGRRCQ 2054
Score = 85.5 bits (210), Expect = 1e-15
Identities = 141/589 (23%), Positives = 201/589 (34%), Gaps = 120/589 (20%)
Query: 2668 PG-PNGAECQCPHEGNWYLANNRKH---CIVDNGERCGASSFTCSNGRCISEEWKCDNDN 2723
PG P G + P YL +R+ V+ + C + C NGRCI C +
Sbjct: 417 PGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCEC 476
Query: 2724 DCGDGSDEMESVCALHTCSPTAFTCANGRCV--QYSYRCDYYNDCGDGSDEAGCLFRDCN 2781
+ G D + C CA G C+ Q SY C C D
Sbjct: 477 NKGFQLDLRGECIDVDECEKNP--CAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDEC 534
Query: 2782 ATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPD-------RTCQSGYTKCHNSN- 2833
+CNN RCI + + V N + T D KNC D C +G C N +
Sbjct: 535 LQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGM--CINEDG 592
Query: 2834 ----ICIPRVYLCDGDNDCGD-NSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETD 2888
IC P L C D N E P C C +++ S RC +
Sbjct: 593 SFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTD---GSYRC-----------E 638
Query: 2889 CFDASDEPASCGHSERTCLADEFK--CDGG----RCIPSEWICDGDNDCGDMSDE----D 2938
CF + G R C+ + C GG +CI + ++C S E +
Sbjct: 639 CFPG----LAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGE 694
Query: 2939 KRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEF 2998
C QN ++ + LC + G + G D N+ C+ +
Sbjct: 695 PCQPCPAQNSAEYQALCSS----------------GPGMTSAGSDINE------CALDPD 732
Query: 2999 TCGYGLC--IPKIFRCDRHNDCGDYSDERGCL-YQTCQQNQFTCQNGRCISK--TFVCD- 3052
C G+C + ++C ++ S + C+ C N C NG+C + +FVC
Sbjct: 733 ICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTC 792
Query: 3053 -------------EDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGR----------CIE 3089
ED D + S + +C P F C+ CIE
Sbjct: 793 PKGFIYKPDLKTCEDIDECESSPCINGVCKNS-----PGSFICECSSESTLDPTKTICIE 847
Query: 3090 MMKLCNHLDDCLDNSDEKGCGIN------ECHDPSISGCDHNCTDTLTSFYCSCRPGYKL 3143
+K C + C IN + S G TL C GY
Sbjct: 848 TIK-----GTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSR 902
Query: 3144 MSDKRTCVDIDECTEMPFVCSQK-CENVIGSYICKCAPGYLREPDGKTC 3191
+ + C DIDEC P VC C N GS+ C+C G + G+ C
Sbjct: 903 IKGTQ-CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950
Score = 85.1 bits (209), Expect = 1e-15
Identities = 110/411 (26%), Positives = 155/411 (37%), Gaps = 82/411 (19%)
Query: 28 CDSAHFRCGSGHCIPA--DWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPN-- 83
C + C +G CIP RC+ K D V C++ C G+CI N
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKN--PCAG-GECINNQG 509
Query: 84 SWVCDQDQDCDDGSDE---RQDCSQ-STCSSHQITCSNGQCIPSE--YRCD-----HV-R 131
S+ C C G R +C C + C+NG+CI ++ + C HV R
Sbjct: 510 SYTCQ----CRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTR 565
Query: 132 DCPDGADENDCQYPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEINCTEICLHNEFS 189
D + D ++C C NG C N S KC K + +SD C +I NE
Sbjct: 566 DGKNCEDMDECSIRNM----CLNGMCINEDGSFKCICKPGFQLASDGRYCKDI---NECE 618
Query: 190 ----CGNGECIPR--AYVCDHDNDCQDGSDEHAC----NYPTC-GGYQFTCPSGRCIYQN 238
C NG C+ +Y C+ G D C TC GGY+ G+CI
Sbjct: 619 TPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYK----RGQCIKPL 674
Query: 239 WVCDGEDDCKDNGDEDG-------------------CESGP------HDVHKCSPREWSC 273
+ + +C E C SGP D+++C+ C
Sbjct: 675 FGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDIC 734
Query: 274 PESGRCISIYKVCDGILDCPGREDENNTSTGKYC----SMTLCSALNCQYQCHETPYGGA 329
P +G C ++ G C STGK C L S L QC TP
Sbjct: 735 P-NGICENLR----GTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFV 789
Query: 330 CFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILE 380
C CP G+I D +TC + D+C+ + C++ PG +C C L+
Sbjct: 790 CTCPKGFIYKP-DLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLD 839
Score = 84.7 bits (208), Expect = 2e-15
Identities = 161/654 (24%), Positives = 234/654 (35%), Gaps = 138/654 (21%)
Query: 3480 CLIKPGGKGFTCECPDDFRT-LQLSGSTYCMPMCSSTQFLCA-----NNE-----KCIPI 3528
C+ PG F C+C + + + + + + C LC N E +C P
Sbjct: 1086 CVNTPGD--FECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPG 1143
Query: 3529 WWKCDGQKDCSDGSD-ELA--LCPQRFC--RLGQFQCS--DGNCTSPQTL-CNAHQNCPD 3580
C D ++ EL+ LCP C +G++QC+ G ++P L C C
Sbjct: 1144 HQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSI 1203
Query: 3581 GSDEDRLLCENHHCDSNEWQCA-NKRCIPESWQCDTFNDCEDNSDE-DSSHCASRTCRPG 3638
+ C N S E C +P+ C ++CEDN + D C T PG
Sbjct: 1204 MNGGCETFCTNSE-GSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQC---TNIPG 1259
Query: 3639 QFRCA--NGRCIPQAWKCDVD-NDCGDHSDEPIEECMSSAHLCDNFTEFS----CKTNYR 3691
++RC +G + K VD N+C D C+S C+N T+ S C Y
Sbjct: 1260 EYRCLCYDGFMASEDMKTCVDVNEC----DLNPNICLSGT--CEN-TKGSFICHCDMGYS 1312
Query: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCK--------NHHCIPLRWQCDGQN 3743
C +++C + G + G F+C C L +G +
Sbjct: 1313 GKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTH 1372
Query: 3744 DCGDNSDEEN------CAPRE--------------CTESEFRCVNQQCI--PSRWICDHY 3781
C ++D +N C +E C+E+ C N QC+ P + C+
Sbjct: 1373 MCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECD 1432
Query: 3782 NDCGDNSDERDCE------------MRTCH--PEYFQCTSGHCVHSELKCDGSADCLDAS 3827
++D + CE TCH P F+C + EL G +C D +
Sbjct: 1433 MGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECE--IGYELDRSGG-NCTDVN 1489
Query: 3828 DEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHL----CLDVP- 3882
+ D PT G N V P + CD D EL+ C+D
Sbjct: 1490 ECLD-PTTCISG-----------NCVNTPGSYICDCPPDF------ELNPTRVGCVDTRS 1531
Query: 3883 --CNSPNRFRCDNNRCIYSHEVCNGVDD---CGDGTDETEEHCRKPTPKPCTEYEYKCGN 3937
C R R DN S+E+ GV C C +EY+ C
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPG 1591
Query: 3938 GHCI---PHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAG 3994
G P + +D D+C + C GK C G F C C G
Sbjct: 1592 GEGFRPNPITVILEDIDECQELPGL--CQGGK---CINTF----------GSFQCRCPTG 1636
Query: 3995 FETNVFDRTSCLDINECEQFGTC-PQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
+ N D C D+NECE G C P C NT G+Y C+C + M G C
Sbjct: 1637 YYLNE-DTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDY--MQVNGGNNC 1687
Score = 84.0 bits (206), Expect = 3e-15
Identities = 157/694 (22%), Positives = 234/694 (33%), Gaps = 174/694 (25%)
Query: 3467 NPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPM------------CSS 3514
N C CSH I G F C C F+T T C+ + C +
Sbjct: 1851 NECQEIPNICSHGQCIDTVGS-FYCLCHTGFKTND--DQTMCLDINECERDACGNGTCRN 1907
Query: 3515 T----------QFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGN 3564
T F+ ++N CI + +C+ G+ L Q +G FQC
Sbjct: 1908 TIGSFNCRCNHGFILSHNNDCIDV-------DECASGNGNLCRNGQCINTVGSFQCQ--- 1957
Query: 3565 CTSPQTLCN-AHQNCPDGS---DEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFND 3618
CN ++ PDG D + L E C Q + RCI
Sbjct: 1958 -------CNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK 2010
Query: 3619 CEDNSD--EDSSHCASRTCR--PGQFRCA---------------------------NGRC 3647
CED + E+ CA TC G F+C G+C
Sbjct: 2011 CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKC 2070
Query: 3648 IPQAWKCDVDNDC-----GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGV 3702
+ +C G+ +P E C + + F + C + G
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPD--EAFRQI-------CPYGSGIIVGP 2121
Query: 3703 DDCRDNSDE----QGCEERTC-HPVGDFRCK--------NHHCIPLRWQCDGQNDCGDNS 3749
DD + DE C+ C + G +RC+ + C+ +C N CG+ +
Sbjct: 2122 DDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTD-ECSVGNPCGNGT 2180
Query: 3750 DEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEY----FQC 3805
+ ECT C C+ N+C N C R C Y +C
Sbjct: 2181 CKNVIGGFECT-----CEEGFEPGPMMTCEDINECAQNP--LLCAFR-CVNTYGSYECKC 2232
Query: 3806 TSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHV------CIPPYW 3859
G+ + + + DE +C D C ECKN + C P Y
Sbjct: 2233 PVGYVLREDRRM--------CKDEDECEEGKHD---CTEKQMECKNLIGTYMCICGPGYQ 2281
Query: 3860 KCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGV------DDCGDG- 3912
+ + C D ++ C P N RC N R Y+ E +G D+C D
Sbjct: 2282 RRPDGEGCVDENE-----CQTKPGICENG-RCLNTRGSYTCECNDGFTASPNQDECLDNR 2335
Query: 3913 -----TDETEEHCR--KPTPKPCTEYEYKCGNGHCI-PHDNVCDDADDCGDWSDELGCNK 3964
T+ + C+ P T+ E C G PH +C G + + C
Sbjct: 2336 EGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQ---GTVAFKKLCPH 2392
Query: 3965 GK----------ERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQF 4014
G+ E ++C + G + C C G+ ++ TSC+D+NEC Q
Sbjct: 2393 GRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITG-TSCVDLNECNQA 2451
Query: 4015 GT-CPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
C C+NT+GSY+C C G+ D G+ C
Sbjct: 2452 PKPCNFICKNTEGSYQCSCPKGYILQED--GRSC 2483
Score = 83.2 bits (204), Expect = 6e-15
Identities = 76/284 (26%), Positives = 101/284 (35%), Gaps = 62/284 (21%)
Query: 2913 CDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQ-NCSDSEFLCVNDRPPDRRCIPQSWV 2971
C G+ PS CG S + +C N +CSD LC P V
Sbjct: 102 CPSGQIAPS---------CGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQP---V 149
Query: 2972 CDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQT 3031
C+ C +G R + N C YG P+ R R C + C
Sbjct: 150 CESG--CLNG--------GRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMC---- 195
Query: 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMM 3091
Q Q + VC + C H C CP C G +
Sbjct: 196 --QGQLS---------GIVCTKTLCCATVGRAWGHPCEM----CPAQPHPCRRGFIPNIR 240
Query: 3092 K-LCNHLDDCLDNSDEKGCGINECHDPSISGCDH--NCTDTLTSFYCSCRPGYKLMSDKR 3148
C +D+C +I G NC +T+ SF C C G+KL +
Sbjct: 241 TGACQDVDEC----------------QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQ 284
Query: 3149 TCVDIDECTEMPFVC-SQKCENVIGSYICKCAPGYLREPDGKTC 3191
C DIDEC+ +P +C +C N + SY CKC PG+ PDG C
Sbjct: 285 KCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328
Score = 82.4 bits (202), Expect = 1e-14
Identities = 143/629 (22%), Positives = 221/629 (35%), Gaps = 120/629 (19%)
Query: 3466 SNPCGTNNGGCSHLCLIKPGGKGFTCE-CPDD----FRTLQLSGSTYCMPMCSSTQFL-- 3518
S+P N+ C +K G G CE CP + FR + GS + S +
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130
Query: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD----------GNCTSP 3568
C + C GQ +DGS CP + G +C D GN T
Sbjct: 2131 CKEPDVCK------HGQCINTDGSYRCE-CPFGYILAGN-ECVDTDECSVGNPCGNGTCK 2182
Query: 3569 QTLCNAHQNCPDGSDEDRLL-CEN-HHCDSNEWQCANKRCIPE--SWQCDT------FND 3618
+ C +G + ++ CE+ + C N CA RC+ S++C D
Sbjct: 2183 NVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAF-RCVNTYGSYECKCPVGYVLRED 2241
Query: 3619 CEDNSDEDSSHCASRTCRPGQFRCAN------GRCIPQAWKCDVDNDCGDHSDEPIEECM 3672
DED C Q C N C P + C D + EC
Sbjct: 2242 RRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDEN-----ECQ 2296
Query: 3673 SSAHLCDNFTEFSCKTNY--RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNH 3730
+ +C+N + + +Y C + D+C DN E C + N
Sbjct: 2297 TKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNR-EGYCFTEVLQNMCQIGSSNR 2355
Query: 3731 HCIPL-RWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSD 3789
+ + CDG G + + C Q + + +C H N
Sbjct: 2356 NPVTKSECCCDGGRGWGPHCEI--------------CPFQGTVAFKKLCPHGRGFMTNGA 2401
Query: 3790 ERDCEMRTCHPEYFQCTSGHCV------HSELKCDGSAD-----CLDASDEADCPTRFPD 3838
+ D C + C +G CV H K + D C+D ++ P P
Sbjct: 2402 DID----ECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK--PC 2455
Query: 3839 GAYCQAT--MFEC---KNHVCIPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPNRF 3889
C+ T ++C K ++ C D+C LC++ C P F
Sbjct: 2456 NFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF 2515
Query: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHD-NVCD 3948
+ CI ++E + ++ CG ++ C+ TP T +C G + + C+
Sbjct: 2516 TQHHTSCIDNNECTSDINLCG-----SKGICQN-TPGSFT---CECQRGFSLDQTGSSCE 2566
Query: 3949 DADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDI 4008
D D+C +G R C+ C + GG+ CSC G+ + + C+D
Sbjct: 2567 DVDEC----------EGNHR------CQHGCQNII-GGYRCSCPQGYLQH-YQWNQCVDE 2608
Query: 4009 NECEQFGTCP-QHCRNTKGSYECVCADGF 4036
NEC C C NT GSY+C+C GF
Sbjct: 2609 NECLSAHICGGASCHNTLGSYKCMCPAGF 2637
Score = 81.3 bits (199), Expect = 2e-14
Identities = 125/530 (23%), Positives = 181/530 (34%), Gaps = 116/530 (21%)
Query: 3553 CRLGQFQCSDGNCTSP----QTLCNAH--------QNCPDGSD--EDRLLCENHHCDSNE 3598
CR+ C G C + + C+ +NC D + D LLC C + E
Sbjct: 1074 CRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTE 1133
Query: 3599 --WQCANKRCIPESWQCDTFNDCED-NSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCD 3655
++C C P + C D N E S+H C NGRC+ K
Sbjct: 1134 GSYRC---ECPPGHQLSPNISACIDINECELSAHL-----------CPNGRCVNLIGKYQ 1179
Query: 3656 VDNDCGDHSDEP------IEECMSSAHLCDNFT-------EFSCKTNYRCIPKWAVCNGV 3702
+ G HS I+EC C+ F E SC+ + +P C +
Sbjct: 1180 CACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239
Query: 3703 DDCRDNSDEQGCEERTCHPV-GDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTE 3761
D+C DN + C+ C + G++RC C + C D EC
Sbjct: 1240 DECEDNPNI--CDGGQCTNIPGEYRCL---CYDGFMASEDMKTCVD--------VNECDL 1286
Query: 3762 SEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSA 3821
+ C++ C ++ + D G + + +T + +C G H+ C A
Sbjct: 1287 NPNICLSGTCENTKGSFICHCDMGYSGKKG----KTGCTDINECEIG--AHN---CGKHA 1337
Query: 3822 DCLDASDEADC---PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLC 3878
C + + C P DG C + EC N + C DC + LC
Sbjct: 1338 VCTNTAGSFKCSCSPGWIGDGIKC-TDLDECSNGTHM-----CSQHADCKNTMGSYRCLC 1391
Query: 3879 LDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNG 3938
+ + D C E ++ CG+G C Y +C G
Sbjct: 1392 KE-------GYTGDGFTCTDLDECSENLNLCGNG------QCLNAP----GGYRCECDMG 1434
Query: 3939 HCIPHD-NVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFET 3997
D C+D D+C NIC G F C C G+E
Sbjct: 1435 FVPSADGKACEDIDECS----------------LPNICVFGTCHNLPGLFRCECEIGYE- 1477
Query: 3998 NVFDRT--SCLDINECEQFGTC-PQHCRNTKGSYECVCADGFTSMSDRPG 4044
DR+ +C D+NEC TC +C NT GSY C C F R G
Sbjct: 1478 --LDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVG 1525
Score = 80.9 bits (198), Expect = 3e-14
Identities = 110/451 (24%), Positives = 164/451 (36%), Gaps = 99/451 (21%)
Query: 27 ECDSAHFRCGSGHCI--PADWRC---DG-------TKDCSD----DADEIGCAVVTCQ-- 68
EC + CG G C+ P D+ C +G K+C D D + C C
Sbjct: 1073 ECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNT 1132
Query: 69 QGYFKCQSEG--QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIP--SE 124
+G ++C+ Q PN C +C+ S+H C NG+C+ +
Sbjct: 1133 EGSYRCECPPGHQLSPNISACIDINECE-------------LSAH--LCPNGRCVNLIGK 1177
Query: 125 YRCDHVRDCPDGADENDCQYPTCEQLTCDNGAC--YNTSQKCDWKVDCRDS----SDEIN 178
Y+C D C ++ + NG C + T+ + ++ C+ D+ +
Sbjct: 1178 YQCACNPGYHSTPDRLFCV--DIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRS 1235
Query: 179 CTEI--CLHNEFSCGNGEC--IPRAYVCDHDNDCQDGSDEHAC-NYPTCGGYQFTCPSGR 233
CT+I C N C G+C IP Y C + D C + C C SG
Sbjct: 1236 CTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGT 1295
Query: 234 C--IYQNWVCD---------GEDDCKDNGDEDGCESGPHDVHK--------------CSP 268
C +++C G+ C D + CE G H+ K CSP
Sbjct: 1296 CENTKGSFICHCDMGYSGKKGKTGCTDINE---CEIGAHNCGKHAVCTNTAGSFKCSCSP 1352
Query: 269 REW-----SCPESGRCISIYKVCDGILDCPGRED-------ENNTSTGKYCS-MTLCSA- 314
W C + C + +C DC E T G C+ + CS
Sbjct: 1353 G-WIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSEN 1411
Query: 315 --LNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICD-QKCESRPGRHLC 371
L QC P G C C G++ + D + C + D+C + IC C + PG C
Sbjct: 1412 LNLCGNGQCLNAPGGYRCECDMGFVPSA-DGKACEDIDECSLPNICVFGTCHNLPGLFRC 1470
Query: 372 HCEEGYILER--GQYCKANDSFGEASIIFSN 400
CE GY L+R G N+ + I N
Sbjct: 1471 ECEIGYELDRSGGNCTDVNECLDPTTCISGN 1501
Score = 79.7 bits (195), Expect = 6e-14
Identities = 111/427 (25%), Positives = 158/427 (37%), Gaps = 81/427 (18%)
Query: 22 PASGQECDSAHFRCGSGHCIP--ADWRCDGTKDCSDDADEIGCAVVT-CQQGYFKCQSEG 78
P EC C +G CI +RC+ + + C + CQ G CQ
Sbjct: 1764 PVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPV-CQRNA 1822
Query: 79 QCI--PNSWVCDQDQDCDDG---SDERQDCSQSTCSSHQITCSNGQCIPS--EYRCDHVR 131
+CI S+ CD C G + Q ++ C CS+GQCI + + C
Sbjct: 1823 ECINTAGSYRCD----CKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL--- 1875
Query: 132 DCPDGADENDCQ-----YPTCEQLTCDNGACYNT----SQKCDWKVDCRDSSDEINCTEI 182
C G ND Q CE+ C NG C NT + +C+ ++D I+ E
Sbjct: 1876 -CHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDEC 1934
Query: 183 CLHNEFSCGNGECI-----------------PRAYVCDHDNDCQDGSDEHACNYPTC--- 222
N C NG+CI P C N+C + C TC
Sbjct: 1935 ASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECL--LEPRKCAPGTCQNL 1992
Query: 223 -GGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWS----CPESG 277
G Y+ CP G + QN C+ D+C + + + C G CS E S CPE
Sbjct: 1993 DGSYRCICPPGYSL-QNEKCEDIDECVE--EPEICALGT-----CSNTEGSFKCLCPEGF 2044
Query: 278 RCISIYKVCDGILD--CPGREDENNTSTGK---YCSMTLCSALN-------CQYQCHETP 325
S + C + C + + S+ K + C AL C+ E
Sbjct: 2045 SLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPD 2104
Query: 326 YGGACFCP--PGYIINHNDSRTCVEFDDCQIWGICDQ-KCESRPGRHLCHCEEGYILERG 382
CP G I+ +DS V+ D+C+ +C +C + G + C C GYIL G
Sbjct: 2105 EAFRQICPYGSGIIVGPDDS--AVDMDECKEPDVCKHGQCINTDGSYRCECPFGYIL-AG 2161
Query: 383 QYCKAND 389
C D
Sbjct: 2162 NECVDTD 2168
Score = 79.7 bits (195), Expect = 6e-14
Identities = 142/648 (21%), Positives = 227/648 (35%), Gaps = 139/648 (21%)
Query: 3480 CLIKPGGKGFTCEC-PDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCD-GQKD 3537
CL++P +C P + L S C P S C + ++C+ C G
Sbjct: 1977 CLLEPR------KCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCS 2030
Query: 3538 CSDGSDELALCPQRFCRLGQFQ-CSD------------GNCTSPQTLCNAHQNC-----P 3579
++GS + LCP+ F + C D G C+SP++ ++ Q C
Sbjct: 2031 NTEGSFK-CLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKG 2089
Query: 3580 DGSDEDRLLCENHHCDSNEWQCANKRCI---PESWQCDTFNDCEDNSDEDSSHCASRTCR 3636
+G + LC ++ C I P+ D ++C++ C +
Sbjct: 2090 EGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVD-MDECKEPDVCKHGQCINTD-- 2146
Query: 3637 PGQFRC--------ANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFT---EFS 3685
G +RC A C+ +C V N CG+ + C N E +
Sbjct: 2147 -GSYRCECPFGYILAGNECVDTD-ECSVGNPCGNGT-------------CKNVIGGFECT 2191
Query: 3686 CKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDC 3745
C+ + P C +++C N C R + G + CK LR + + C
Sbjct: 2192 CEEGFEPGPMMT-CEDINECAQNP--LLCAFRCVNTYGSYECKCPVGYVLR---EDRRMC 2245
Query: 3746 GDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC-EMRTCHPEYFQ 3804
D + E +CTE + C N + ++C D C + C +
Sbjct: 2246 KDEDECEE-GKHDCTEKQMECKN---LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGI 2301
Query: 3805 CTSGHCVHSE--LKCDGSADCLDASDEADCPTRFPDGAYCQATMFECK-NHVCIPPYWKC 3861
C +G C+++ C+ + + ++ +C + + C+ P K
Sbjct: 2302 CENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKS 2361
Query: 3862 DGDDDCGDGSDEELHLCLDVPCNSPNRFR-------------CDNNRCIYSHEVC-NG-- 3905
+ D G G +C P F+ D + C H+VC NG
Sbjct: 2362 ECCCDGGRGWGPHCEIC---PFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGEC 2418
Query: 3906 VDDCGD--------------GTDETEEHCRKPTPKPCT--------EYEYKCGNGHCIPH 3943
V+D G GT + + PKPC Y+ C G+ +
Sbjct: 2419 VNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQE 2478
Query: 3944 DN-VCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDR 4002
D C D D+C K+ C + +C GGF C C GF +
Sbjct: 2479 DGRSCKDLDECAT----------KQHNC-QFLCVNTI-----GGFTCKCPPGFTQH---H 2519
Query: 4003 TSCLDINEC-EQFGTCPQH--CRNTKGSYECVCADGFTSMSDRPGKRC 4047
TSC+D NEC C C+NT GS+ C C GF+ D+ G C
Sbjct: 2520 TSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFS--LDQTGSSC 2565
Score = 79.0 bits (193), Expect = 1e-13
Identities = 104/443 (23%), Positives = 156/443 (35%), Gaps = 105/443 (23%)
Query: 27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDA--DEIGCAVVTCQQGY-----FKCQSEGQ 79
EC + G+ C+ D C C + + IG TC++G+ C+ +
Sbjct: 2152 ECPFGYILAGN-ECVDTD-ECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINE 2209
Query: 80 CIPNSWVC---------DQDQDCDDGSDERQD---------CSQST--CSSHQITCSNGQ 119
C N +C + C G R+D C + C+ Q+ C N
Sbjct: 2210 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKN-- 2267
Query: 120 CIPSEYRC---DHVRDCPDG---ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDS 173
+ Y C + PDG DEN+CQ + C+NG C NT + + +C D
Sbjct: 2268 -LIGTYMCICGPGYQRRPDGEGCVDENECQ---TKPGICENGRCLNT--RGSYTCECNDG 2321
Query: 174 SDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEH------------------ 215
+ CL N G C N CQ GS
Sbjct: 2322 FTASPNQDECLDNR----EGYCFTEVL----QNMCQIGSSNRNPVTKSECCCDGGRGWGP 2373
Query: 216 ---ACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCK------DNGDEDGCESGPHDVHKC 266
C + ++ CP GR N D+CK NG+ H + K
Sbjct: 2374 HCEICPFQGTVAFKKLCPHGRGFMTNGA--DIDECKVIHDVCRNGECVNDRGSYHCICKT 2431
Query: 267 SPRE----WSCPESGRCISIYKVCDGILDCPGREDENNTST---------GKYCS-MTLC 312
SC + C K C+ I C E S G+ C + C
Sbjct: 2432 GYTPDITGTSCVDLNECNQAPKPCNFI--CKNTEGSYQCSCPKGYILQEDGRSCKDLDEC 2489
Query: 313 SAL--NCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDC-QIWGICDQK--CESRPG 367
+ NCQ+ C T G C CPPG+ +H +C++ ++C +C K C++ PG
Sbjct: 2490 ATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT---SCIDNNECTSDINLCGSKGICQNTPG 2546
Query: 368 RHLCHCEEGYILER-GQYCKAND 389
C C+ G+ L++ G C+ D
Sbjct: 2547 SFTCECQRGFSLDQTGSSCEDVD 2569
Score = 77.8 bits (190), Expect = 2e-13
Identities = 113/497 (22%), Positives = 169/497 (34%), Gaps = 107/497 (21%)
Query: 2748 CANGRCVQY--SYRCDYY-------NDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPRE- 2797
C +G+C+ SYRC+ N+C D +DE N T + + C E
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNECVD-TDECSVGNPCGNGTCKNVIGGFECTCEEG 2195
Query: 2798 ------FICNGVDNCHDN---------NTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLC 2842
C ++ C N NT C C GY + +C
Sbjct: 2196 FEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECK---CPVGYVLREDRRMCKDEDECE 2252
Query: 2843 DGDNDCGDNSDENPTYCTTHTCSSSEFQCASG-RCIPQHWYCDQETDCFDASDEPASCGH 2901
+G +DC + E T+ C C G + P C E +C +P C +
Sbjct: 2253 EGKHDCTEKQMECKNLIGTYMCI-----CGPGYQRRPDGEGCVDENEC---QTKPGICEN 2304
Query: 2902 SERTCLADEFKC---DGGRCIPSEWICDGDNDCGDMSDEDKRHQCQ----NQN-CSDSEF 2953
+ C DG P++ C DN G E ++ CQ N+N + SE
Sbjct: 2305 GRCLNTRGSYTCECNDGFTASPNQDECL-DNREGYCFTEVLQNMCQIGSSNRNPVTKSEC 2363
Query: 2954 LCVNDR---PPDRRCIPQSWVC------DGDVDCTDGYDENQNCTRRTCSENEFTCGYGL 3004
C R P C Q V G T+G D ++ C C G
Sbjct: 2364 CCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDE------CKVIHDVCRNGE 2417
Query: 3005 CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
C+ ND G Y C+ +T T + C + N+C
Sbjct: 2418 CV---------NDRGSYH----CICKTGYTPDITGTS---------CVDLNECNQAPKPC 2455
Query: 3065 MHLCHTPEPTCPPHEFKCDNGRCI-EMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCD 3123
+C E + ++ C G + E + C LD+C C
Sbjct: 2456 NFICKNTEGS---YQCSCPKGYILQEDGRSCKDLDECATKQHN---------------CQ 2497
Query: 3124 HNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK--CENVIGSYICKCAPG 3181
C +T+ F C C PG+ +C+D +ECT +C K C+N GS+ C+C G
Sbjct: 2498 FLCVNTIGGFTCKCPPGFT--QHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRG 2555
Query: 3182 YLREPDGKTCRQNSNIE 3198
+ + G +C E
Sbjct: 2556 FSLDQTGSSCEDVDECE 2572
Score = 77.0 bits (188), Expect = 4e-13
Identities = 59/192 (30%), Positives = 75/192 (39%), Gaps = 33/192 (17%)
Query: 1257 LYGSDEHNACVPKT----CPSSYFHCDNGNCIHRAWLC----------DRDNDCGDMSDE 1302
LY S E +P C + C NG CI C D +C D+ +
Sbjct: 435 LYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDEC 494
Query: 1303 KDCPTQPFRC----PSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNG 1358
+ P C S+ QC C I +C L NG C+ NG
Sbjct: 495 EKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDEC--------LQNGRICN--NG 544
Query: 1359 GCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC-SQHCYNMRGSFRCSCDT 1417
C+ C+C GF + D K CED+DEC I C + C N GSF+C C
Sbjct: 545 ----RCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKP 600
Query: 1418 GYMLESDGRTCK 1429
G+ L SDGR CK
Sbjct: 601 GFQLASDGRYCK 612
Score = 75.5 bits (184), Expect = 1e-12
Identities = 90/419 (21%), Positives = 150/419 (35%), Gaps = 76/419 (18%)
Query: 27 ECDSAHFRCGSGHCIPA--DWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNS 84
EC+ C +G C+ ++C + DA C + + + + + E +P +
Sbjct: 913 ECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIA 972
Query: 85 WVCDQDQDCDD-----GSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADE 139
D C G++E ++C ++ C G P + P D
Sbjct: 973 GRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRG---PGFATKEITNGKPFFKDI 1029
Query: 140 NDCQYPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEINCTEI--CLHNEFSCGNGEC 195
N+C+ C +G C NT S KC S+E NCT+I C + CG G+C
Sbjct: 1030 NECKMIPS---LCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQC 1086
Query: 196 I--PRAYVCDHDNDCQDG--SDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNG 251
+ P + C D + G ++ + C C G C N +C
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVC--HNTEGSYRCECPPGH 1144
Query: 252 DEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYC-SMT 310
S D+++C CP +GRC+++ G C ++T +C +
Sbjct: 1145 QLSPNISACIDINECELSAHLCP-NGRCVNLI----GKYQCACNPGYHSTPDRLFCVDID 1199
Query: 311 LCSALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW-GICDQ------- 360
CS +N C+ C + C C PG+ + D R+C + D+C+ ICD
Sbjct: 1200 ECSIMNGGCETFCTNSEGSYECSCQPGFALMP-DQRSCTDIDECEDNPNICDGGQCTNIP 1258
Query: 361 ------------------------------------KCESRPGRHLCHCEEGYILERGQ 383
CE+ G +CHC+ GY ++G+
Sbjct: 1259 GEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGK 1317
Score = 73.9 bits (180), Expect = 3e-12
Identities = 124/530 (23%), Positives = 192/530 (36%), Gaps = 106/530 (20%)
Query: 3593 HCDSNEWQCANKRCIP----------ESWQCDTFNDCEDNSDEDSSHCASRTC--RPGQF 3640
+C + C N RCIP + +Q D +C D + + + CA C G +
Sbjct: 452 YCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSY 511
Query: 3641 RCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCN 3700
C +C +C D I+EC+ + +C+N + ++ C VCN
Sbjct: 512 TC---QCRAGYQSTLTRTECRD-----IDECLQNGRICNNGRCINTDGSFHC-----VCN 558
Query: 3701 -GVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCI--PLRWQCDGQNDCGDNSDEENCAPR 3757
G RD + + +E + + C N CI ++C + SD C
Sbjct: 559 AGFHVTRDGKNCEDMDECSIRNM----CLNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614
Query: 3758 ECTESEFRCVNQQCI--PSRWICDHYNDCGDNSDERDC---EMR-TCHPEYFQCTSGHCV 3811
E+ C+N +C+ + C+ + D R C MR TC+ Y G C+
Sbjct: 615 NECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGY---KRGQCI 671
Query: 3812 HSELKCDGSADCLDASDE-------ADCPTR-----------FPDGAYCQATMFECKNHV 3853
++C AS E CP + P + + EC
Sbjct: 672 KPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDP 731
Query: 3854 CIPPYWKCD---GDDDCGDGSDEELHL----CLDVPCNSPNRFRCDNNRCIYSHEVCNGV 3906
I P C+ G C S E+ C+D+ N CDN +C + + V
Sbjct: 732 DICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQC--RNTPGSFV 789
Query: 3907 DDCGDGTDETEEHCRKPTPKPCTEYE----YKCGNGHC--IPHDNVCDDADDCGDWSDEL 3960
C G KP K C + + C NG C P +C+ + + +
Sbjct: 790 CTCPKG------FIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKT 843
Query: 3961 GCNKGKERTCAENICEQNCTQLNEGGF-----ICS---------CT-------AGFETNV 3999
C + + TC + + + C ++N G CS CT G +
Sbjct: 844 ICIETIKGTCWQTVIDGRC-EININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSR 902
Query: 4000 FDRTSCLDINECEQF-GTCPQH-CRNTKGSYECVCADGFTSMSDRPGKRC 4047
T C DI+ECE F G C C NT+GS++C C G T D G+ C
Sbjct: 903 IKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMT--LDATGRIC 950
Score = 73.6 bits (179), Expect = 4e-12
Identities = 62/225 (27%), Positives = 86/225 (38%), Gaps = 23/225 (10%)
Query: 1223 PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVP-KTCPSSYFHCDNG 1281
P C + CQ +G CIP C + + D C+ C + C G
Sbjct: 446 PVNVTDYCQLVRYLCQ-NGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKN--PCAGG 502
Query: 1282 NCIHR--AWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHN-ICVNLSVV-CDGIFD 1337
CI+ ++ C +C +CL + IC N + DG F
Sbjct: 503 ECINNQGSYTCQCRAGYQSTLTRTECRDID--------ECLQNGRICNNGRCINTDGSFH 554
Query: 1338 CPNGTDESPLCNGNSCSDF------NGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDI 1391
C +G +C D N C+ E KC+C GF LA+D + C+DI
Sbjct: 555 CVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614
Query: 1392 DECDILGSCSQ-HCYNMRGSFRCSCDTGYMLESDGRTCKVTASES 1435
+EC+ G C C N GS+RC C G + DGR C T S
Sbjct: 615 NECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRS 659
Score = 73.6 bits (179), Expect = 4e-12
Identities = 104/466 (22%), Positives = 154/466 (33%), Gaps = 82/466 (17%)
Query: 998 CGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
C CP G L + C+ + E C CKN + Y+C D
Sbjct: 2230 CKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKN---LIGTYMCICGPGYQRRPDG 2286
Query: 1058 QLCGTLNNTCSSSAFTCGHGECIPAH--WRCDKRNDCVDGSDEHNCPTHAPASCLDT--- 1112
+ C N C + C +G C+ + C+ + ++ C + C
Sbjct: 2287 EGCVD-ENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQ 2345
Query: 1113 ---QYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHR--------- 1160
Q N ++K+ C D G G + C T + CP+ R
Sbjct: 2346 NMCQIGSSNRNPVTKSECC-CDGGRGWGPHCEICPFQGTVAFKKL-CPHGRGFMTNGADI 2403
Query: 1161 --CIDLSFVCDGDKDCVDGSDEVGCVLNC----TASQFKCASGDKCIGVTNRCDGVFDCS 1214
C + VC +CV+ C+ + C ++C C+ + +
Sbjct: 2404 DECKVIHDVCRNG-ECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNT 2462
Query: 1215 DNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNA---CVPKTC 1271
+ S + CP + QEDG + EC + +HN CV T
Sbjct: 2463 EGSYQCSCPKG---------YILQEDGRSCKDLDEC--------ATKQHNCQFLCV-NTI 2504
Query: 1272 PSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVV 1331
C G H C +N+C SD C ++ IC N
Sbjct: 2505 GGFTCKCPPGFTQHHT-SCIDNNEC--TSDINLCGSK--------------GICQNTP-- 2545
Query: 1332 CDGIFDCPNGTDESPLCNGNSCSDF-----NGGCTHECVQEPFGAKCLCPLGFLLANDSK 1386
G F C S G+SC D N C H C G +C CP G+L
Sbjct: 2546 --GSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWN 2603
Query: 1387 TCEDIDEC---DILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCK 1429
C D +EC I G S C+N GS++C C G+ E C+
Sbjct: 2604 QCVDENECLSAHICGGAS--CHNTLGSYKCMCPAGFQYEQFSGGCQ 2647
Score = 72.0 bits (175), Expect = 1e-11
Identities = 58/219 (26%), Positives = 86/219 (39%), Gaps = 34/219 (15%)
Query: 3032 CQQNQFTCQNGRCI----------SKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFK 3081
CQ ++ CQNGRCI +K F D +C D + + C E +
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYT 512
Query: 3082 CDNGRCIEMMKL---CNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCR 3138
C + C +D+CL N G C +T SF+C C
Sbjct: 513 CQCRAGYQSTLTRTECRDIDECLQNGRICNNG--------------RCINTDGSFHCVCN 558
Query: 3139 PGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
G+ + D + C D+DEC+ + C N GS+ C C PG+ DG+ C+ + E
Sbjct: 559 AGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECE 618
Query: 3199 PYLIFSNRYYLRNLTIDGYF----YSLILEGLDNVVALD 3233
I N R + DG + + + GLD V +D
Sbjct: 619 TPGICMNG---RCVNTDGSYRCECFPGLAVGLDGRVCVD 654
Score = 71.2 bits (173), Expect = 2e-11
Identities = 121/522 (23%), Positives = 181/522 (34%), Gaps = 120/522 (22%)
Query: 967 IQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCE-----GDPTNEP 1021
+ T S C P GD N C G+ ++ C G P
Sbjct: 1527 VDTRSGNCYLDIRPRGD---------NGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMC 1577
Query: 1022 PTEQCGLFSFPCKNG---RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGE 1078
P + C G R P + + +D+C ++L G C G+
Sbjct: 1578 PAVNTSEYKILCPGGEGFRPNPITVILEDIDEC-----QELPGL-----------CQGGK 1621
Query: 1079 CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGS 1138
CI GS + CPT + DT+ D ++C +T CG G+
Sbjct: 1622 CINTF-----------GSFQCRCPTGYYLN-EDTRVCDDVNEC-------ETPGICGPGT 1662
Query: 1139 DEKNC-NSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASG 1197
N T C P +G +C+D + C N A C G
Sbjct: 1663 CYNTVGNYTCICPPDYMQV------------NGGNNCMDMRRSL-CYRNYYADNQTC-DG 1708
Query: 1198 DKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMC---HSDEFQC----QEDGICIPNFW-- 1248
+ +T + + CS N A +P C +DEF Q G I +
Sbjct: 1709 ELLFNMTKK---MCCCSYNIGRAW--NKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGL 1763
Query: 1249 -----ECDGHPDCLYGSDEHNACVPKT------CPSSYFH------CDNGNCIHRAWLCD 1291
EC P G E+ C+ CP +F+ C++ + +C
Sbjct: 1764 PVDIDECREIP----GVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQ 1819
Query: 1292 RDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCD--------GIFDCPNGTD 1343
R+ +C + + C +P + QC N C + +C G F C T
Sbjct: 1820 RNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTG 1879
Query: 1344 ESPLCNGNSCSDFN----GGCTHECVQEPFGA-KCLCPLGFLLANDSKTCEDIDECDILG 1398
+ C D N C + + G+ C C GF+L++++ C D+DEC
Sbjct: 1880 FKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNND-CIDVDECASGN 1938
Query: 1399 S--CSQ-HCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLL 1437
C C N GSF+C C+ GY + DGRTC V +E LL
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC-VDINECLL 1979
Score = 67.4 bits (163), Expect = 3e-10
Identities = 107/493 (21%), Positives = 161/493 (32%), Gaps = 121/493 (24%)
Query: 13 LLALVACLAPASGQECDSAHFRCGSGHCIPADWRC--------DGTKDCSDDADE----I 60
LL C+ EC +C G+ + D R +G DC++ E I
Sbjct: 2215 LLCAFRCVNTYGSYEC-----KCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLI 2269
Query: 61 GCAVVTCQQGYFK------CQSEGQCIPNSWVCDQDQ----------DCDDG------SD 98
G + C GY + C E +C +C+ + +C+DG D
Sbjct: 2270 GTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQD 2329
Query: 99 ERQDCSQSTCSSH------QITCSNGQCIP-SEYRCD-------HVRDCP---------- 134
E D + C + QI SN + SE CD H CP
Sbjct: 2330 ECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKL 2389
Query: 135 ---------DGADENDCQYPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEINCTEIC 183
+GAD ++C+ C NG C N S C K +C ++
Sbjct: 2390 CPHGRGFMTNGADIDECKVI---HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLN 2446
Query: 184 LHNE------FSCGNGE-----CIPRAYVCDHDN-DCQD----GSDEHACNY---PTCGG 224
N+ F C N E P+ Y+ D C+D + +H C + T GG
Sbjct: 2447 ECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGG 2506
Query: 225 YQFTCPSGRCIYQNWVCDGEDDCKDN---GDEDGCESGPHDVHKCSPREWSCPESGRCIS 281
+ CP G + D + D G + C++ P R +S ++G
Sbjct: 2507 FTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCE 2566
Query: 282 IYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQ------------------CHE 323
C+G C + N G CS + Q+ CH
Sbjct: 2567 DVDECEGNHRC--QHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHN 2624
Query: 324 TPYGGACFCPPGYIINHNDSRTCVEFDDC-QIWGICDQKCESRPGRHLCHCEEGYILERG 382
T C CP G+ S C + ++C C C + G +LC C GY
Sbjct: 2625 TLGSYKCMCPAGFQYEQF-SGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQ 2683
Query: 383 QYCKANDSFGEAS 395
+C + G +
Sbjct: 2684 GHCVSGMGMGRGN 2696
Score = 63.9 bits (154), Expect = 3e-09
Identities = 93/400 (23%), Positives = 138/400 (34%), Gaps = 85/400 (21%)
Query: 27 ECDSAHFRCGSGHCIP--ADWRCDGTKDCSDDADEIGCAVVT-CQQGYFKCQSEGQCIPN 83
EC+ + C +G C+ ++C D + C + C C++
Sbjct: 1158 ECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEG 1217
Query: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC--IPSEYRCDHVRDCPDG----- 136
S+ C D+R C + C GQC IP EYRC C DG
Sbjct: 1218 SYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCL----CYDGFMASE 1273
Query: 137 -----ADENDCQYPTCEQLTCDNGACYNTSQK----CDW-------KVDCRDSSDEINCT 180
D N+C C +G C NT CD K C D IN
Sbjct: 1274 DMKTCVDVNECDL---NPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTD----INEC 1326
Query: 181 EICLHN--------------EFSCGNGECIPRAYVCDHDNDCQDGS---DEHACNYPTCG 223
EI HN + SC G I C ++C +G+ +HA T G
Sbjct: 1327 EIGAHNCGKHAVCTNTAGSFKCSCSPG-WIGDGIKCTDLDECSNGTHMCSQHADCKNTMG 1385
Query: 224 GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Y+ C G + C D+C +N ++ C +G+C++
Sbjct: 1386 SYRCLCKEGYT-GDGFTCTDLDECSEN------------LNLCG--------NGQCLN-- 1422
Query: 284 KVCDGILDCPGREDENNTSTGKYCS-MTLCSALN-CQY-QCHETPYGGACFCPPGYIINH 340
G C ++ GK C + CS N C + CH P C C GY ++
Sbjct: 1423 --APGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDR 1480
Query: 341 NDSRTCVEFDDCQIWGIC-DQKCESRPGRHLCHCEEGYIL 379
+ C + ++C C C + PG ++C C + L
Sbjct: 1481 SGGN-CTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL 1519
Score = 60.8 bits (146), Expect = 3e-08
Identities = 55/216 (25%), Positives = 82/216 (37%), Gaps = 36/216 (16%)
Query: 177 INCTEICLHNEFSCGNGECIP----------RAYVCDHDNDCQDGSDEHACNYPTCGGYQ 226
+N T+ C + C NG CIP + + D +C D + C C G
Sbjct: 447 VNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDE---CEKNPCAG-- 501
Query: 227 FTCPSGRCIYQ--NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYK 284
G CI ++ C C+ + D+ +C C +GRCI+
Sbjct: 502 -----GECINNQGSYTC----QCRAGYQSTLTRTECRDIDECLQNGRIC-NNGRCIN--- 548
Query: 285 VCDGILDCPGREDENNTSTGKYC-SMTLCSALN--CQYQCHETPYGGACFCPPGYIINHN 341
DG C + T GK C M CS N C C C PG+ + +
Sbjct: 549 -TDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQL-AS 606
Query: 342 DSRTCVEFDDCQIWGIC-DQKCESRPGRHLCHCEEG 376
D R C + ++C+ GIC + +C + G + C C G
Sbjct: 607 DGRYCKDINECETPGICMNGRCVNTDGSYRCECFPG 642
Score = 60.1 bits (144), Expect = 5e-08
Identities = 86/375 (22%), Positives = 126/375 (33%), Gaps = 69/375 (18%)
Query: 19 CLAPASGQECDSAHFRCGSG-HCIPADWRCDGTKDCSDDAD---EIGCAVVTCQQGY--- 71
C A +C + G G C D +GT CS AD +G C++GY
Sbjct: 1339 CTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGD 1398
Query: 72 -FKCQSEGQCIPNSWVCDQDQ----------DCDDG---SDERQDCSQSTCSSHQITCSN 117
F C +C N +C Q +CD G S + + C S C
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVF 1458
Query: 118 GQC--IPSEYRCD----HVRDCPDG--ADENDCQYPTCEQLTCDNGACYNT--SQKCDWK 167
G C +P +RC+ + D G D N+C PT TC +G C NT S CD
Sbjct: 1459 GTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPT----TCISGNCVNTPGSYICDCP 1514
Query: 168 VDCRDSSDEINCTEICLHN------------EFSCGN--GECIPRAYVCDHDNDCQDGSD 213
D + + C + N + +C N G + +A C G+
Sbjct: 1515 PDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAW-GTP 1573
Query: 214 EHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSC 273
C Y+ CP G N + +D + + G G ++ + C
Sbjct: 1574 CEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRC 1633
Query: 274 PESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCP 333
P +VCD + +C T C C+ T C CP
Sbjct: 1634 PTGYYLNEDTRVCDDVNEC---------ETPGICG---------PGTCYNTVGNYTCICP 1675
Query: 334 PGYIINHNDSRTCVE 348
P Y + N C++
Sbjct: 1676 PDY-MQVNGGNNCMD 1689
Score = 53.1 bits (126), Expect = 6e-06
Identities = 82/379 (21%), Positives = 132/379 (34%), Gaps = 79/379 (20%)
Query: 27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
EC C G CI + G C GY+ + ++ V
Sbjct: 1609 ECQELPGLCQGGKCI----------------NTFGSFQCRCPTGYYLNE-------DTRV 1645
Query: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCI--PSEYRCDHVRDCPDGADENDCQY 144
CD +C+ C TC + T N CI P + + +C D +
Sbjct: 1646 CDDVNECETPGI----CGPGTCYN---TVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRN 1698
Query: 145 PTCEQLTCDNGACYNTSQK---CDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYV 201
+ TCD +N ++K C + + + C I +EF+ G P +V
Sbjct: 1699 YYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCP-IPSTDEFATLCGSQRP-GFV 1756
Query: 202 CD-------HDNDCQD--GSDEHACNYPTCGGYQFTCPSGRCIYQN---WVCDGEDDCKD 249
D ++C++ G E+ G ++ CP G + N VC+
Sbjct: 1757 IDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVG--FFYNDKLLVCE------- 1807
Query: 250 NGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSM 309
D D C++GP C + CI+ G C + TSTG+
Sbjct: 1808 --DIDECQNGP-----------VCQRNAECINTA----GSYRCDCKPGYRFTSTGQCNDR 1850
Query: 310 TLCSALN--CQY-QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRP 366
C + C + QC +T C C G+ N +D C++ ++C+ + C +
Sbjct: 1851 NECQEIPNICSHGQCIDTVGSFYCLCHTGFKTN-DDQTMCLDINECERDACGNGTCRNTI 1909
Query: 367 GRHLCHCEEGYILERGQYC 385
G C C G+IL C
Sbjct: 1910 GSFNCRCNHGFILSHNNDC 1928
Score = 52.4 bits (124), Expect = 1e-05
Identities = 68/294 (23%), Positives = 93/294 (31%), Gaps = 60/294 (20%)
Query: 1165 SFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPT 1224
++ C G K G+ C + + GD N C C C +
Sbjct: 65 AYCCPGWKTLPGGNQ-------CIVPICRHSCGDGFCSRPNMCT----CPSGQIAPSCGS 113
Query: 1225 RPPGMCHSDEFQCQEDGICIPNFWECD--------GHPDCLYGSDEHNACV-PKTCPSSY 1275
R C+ +C G C + C G P C G CV P C +Y
Sbjct: 114 RSIQHCN---IRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTY 170
Query: 1276 F----HCDN----GNCIH-----------RAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQ 1316
C+ G C +C + C + P + CP+
Sbjct: 171 GFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE--MCPAQP 228
Query: 1317 WQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCP 1376
C I + C + +C LC G +C + G +C CP
Sbjct: 229 HPCRRGFIPNIRTGACQDVDECQAIPG---LCQGGNCINTVGSF-----------ECKCP 274
Query: 1377 LGFLLANDSKTCEDIDECD-ILGSC-SQHCYNMRGSFRCSCDTGYMLESDGRTC 1428
G L S+ CEDIDEC I G C C N S+ C C G+ DG C
Sbjct: 275 AGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328
Score = 52.0 bits (123), Expect = 1e-05
Identities = 81/359 (22%), Positives = 124/359 (34%), Gaps = 76/359 (21%)
Query: 1000 CPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPN---YYL------------ 1044
CP+G G TN ++C + C+NG CV + Y+
Sbjct: 2390 CPHG----------RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITG 2439
Query: 1045 --CDGVDDCHDNSDEQLCGTL-NNTCSSSAFTCGHGECIPAHWR-CDKRNDCVDGSDEHN 1100
C +++C N + C + NT S +C G + R C ++C + +HN
Sbjct: 2440 TSCVDLNEC--NQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECA--TKQHN 2495
Query: 1101 CPTHAPASCLDT--QYTCDNHQCISKNWV-CDTDNDCGDGSDEKNCNSTETCQ--PSQFN 1155
C C++T +TC +++ C +N+C SD C S CQ P F
Sbjct: 2496 CQF----LCVNTIGGFTCKCPPGFTQHHTSCIDNNECT--SDINLCGSKGICQNTPGSFT 2549
Query: 1156 CPNHRCIDLSFV---------CDGDKDCVDGSDEVGCVLNCTASQF--------KCASGD 1198
C R L C+G+ C G + C+ Q +C +
Sbjct: 2550 CECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDEN 2609
Query: 1199 KCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWEC-DGHPDCL 1257
+C+ + C G C + C MC + Q G C + EC C
Sbjct: 2610 ECLSA-HICGGA-SCHNTLGSYKC------MCPAGFQYEQFSGGC-QDINECGSAQAPCS 2660
Query: 1258 YGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDND----CGDMSDEKDCPTQPFRC 1312
YG CP YF G+C+ + R N G+M D P + C
Sbjct: 2661 YGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGM-GRGNPEPPVSGEMDDNSLSPEACYEC 2718
Score = 50.1 bits (118), Expect = 5e-05
Identities = 80/337 (23%), Positives = 106/337 (31%), Gaps = 93/337 (27%)
Query: 3741 GQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHP 3800
G N CG + C + +C+ +P IC H CGD R M TC
Sbjct: 55 GPNVCGSRYNAYCCPGWKTLPGGNQCI----VP---ICRH--SCGDGFCSRP-NMCTCPS 104
Query: 3801 EYF--QCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMF--ECKNHVCIP 3856
C S H ++C C D D CQ C VC
Sbjct: 105 GQIAPSCGSRSIQHCNIRCMNGGSCSD------------DHCLCQKGYIGTHCGQPVC-- 150
Query: 3857 PYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNN----RC-----------IYSHE 3901
+ C +G C +PNR C +C + S++
Sbjct: 151 -------ESGCLNGGR----------CVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQ 193
Query: 3902 VCNGVDDCGDGTDETEEHCRKPTPKP-------CTEYEYKCGNGHCIPH--DNVCDDADD 3952
+C G G T+ C + C + C G IP+ C D D+
Sbjct: 194 MCQGQLS---GIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGF-IPNIRTGACQDVDE 249
Query: 3953 CGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECE 4012
C +C+ G F C C AG + N + C DI+EC
Sbjct: 250 C---------------QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQ-KCEDIDECS 293
Query: 4013 QF-GTCPQ-HCRNTKGSYECVCADGFTSMSDRPGKRC 4047
G C C NT SY C C GF + D G RC
Sbjct: 294 TIPGICEGGECTNTVSSYFCKCPPGFYTSPD--GTRC 328
Score = 49.3 bits (116), Expect = 9e-05
Identities = 111/515 (21%), Positives = 156/515 (30%), Gaps = 104/515 (20%)
Query: 2636 QPRGINTVVKNQKQQCNNPCEQFNGGC-----SHIC------APGPNGAECQCPHEGNWY 2684
+P G V +N+ Q CE NG C S+ C PN EC EG +
Sbjct: 2283 RPDGEGCVDENECQTKPGICE--NGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCF 2340
Query: 2685 LANNRKHCIVDNGER--CGASSFTCSNGRCISEEWK-CDNDND------CGDGSDEMESV 2735
+ C + + R S C GR + C C G M +
Sbjct: 2341 TEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG 2400
Query: 2736 CALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDG--SDEAGCLFRDCNATTEFMCNNRRC 2793
+ C C NG CV + R Y+ C G D G D N N+
Sbjct: 2401 ADIDECKVIHDVCRNGECV--NDRGSYHCICKTGYTPDITGTSCVDLNEC------NQAP 2452
Query: 2794 IPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSD 2853
P FIC NT C +C GY + C D D
Sbjct: 2453 KPCNFICK--------NTEGSYQC---SCPKGYILQEDGRSC--------KDLDECATKQ 2493
Query: 2854 ENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKC 2913
N + +T +C G H C +C + S G + T + +C
Sbjct: 2494 HNCQFLCVNTIGGFTCKCPPG-FTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCEC 2552
Query: 2914 DGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCD 2973
G + + C D+ + + H+CQ+ C N R PQ ++
Sbjct: 2553 QRGFSLDQT-----GSSCEDVDECEGNHRCQHG--------CQNIIGGYRCSCPQGYL-- 2597
Query: 2974 GDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQT-C 3032
Y NQ C CG C HN G Y C+
Sbjct: 2598 ------QHYQWNQCVDENECLSAHI-CGGASC---------HNTLGSYK----CMCPAGF 2637
Query: 3033 QQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPT----CPPHEFKCDNGRCI 3088
Q QF+ C + N+CG + C E CPP F+ G C+
Sbjct: 2638 QYEQFSGG----------CQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCV 2687
Query: 3089 EMMKL--CNHLDDCLDNSDEKGCGINECHDPSISG 3121
M + N D+ C++ I+G
Sbjct: 2688 SGMGMGRGNPEPPVSGEMDDNSLSPEACYECKING 2722
Score = 47.8 bits (112), Expect = 3e-04
Identities = 105/458 (22%), Positives = 151/458 (32%), Gaps = 105/458 (22%)
Query: 3467 NPCGTNNGGCSH-LCLIKPGGKGFTCECPDDFRTLQLSGST------YCMP-----MC-- 3512
N C T G C + CL G +TCEC D F YC MC
Sbjct: 2293 NECQTKPGICENGRCLNTRGS--YTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQI 2350
Query: 3513 -SSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELA---------LCPQRF---------- 3552
SS + +E C CDG + + LCP
Sbjct: 2351 GSSNRNPVTKSECC------CDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADID 2404
Query: 3553 -CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRC----- 3606
C++ C +G C + + + H C G D + D NE A K C
Sbjct: 2405 ECKVIHDVCRNGECVNDRG--SYHCICKTGYTPD--ITGTSCVDLNECNQAPKPCNFICK 2460
Query: 3607 -IPESWQCDTFNDC----EDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCG 3661
S+QC + S +D CA++ QF C N + C
Sbjct: 2461 NTEGSYQCSCPKGYILQEDGRSCKDLDECATKQ-HNCQFLCVN---TIGGFTCKCPPGFT 2516
Query: 3662 DHSDEPIE--ECMSSAHLCDN----------FTEFSCKTNYRCIPKWAVCNGVDDCRDNS 3709
H I+ EC S +LC + FT C+ + + C VD+C N
Sbjct: 2517 QHHTSCIDNNECTSDINLCGSKGICQNTPGSFT-CECQRGFSLDQTGSSCEDVDECEGNH 2575
Query: 3710 D-EQGCEERTCHPVGDFRCK--NHHCIPLRW-QCDGQNDCGDNSDEENCAPREC--TESE 3763
+ GC+ + +G +RC + +W QC +N+C C C T
Sbjct: 2576 RCQHGCQ----NIIGGYRCSCPQGYLQHYQWNQCVDENEC---LSAHICGGASCHNTLGS 2628
Query: 3764 FRCVNQQCIPSRWI---CDHYNDCGDN--------SDERDCEMRTCHPEYFQCTSGHCVH 3812
++C+ C N+CG S+ + C P YF+ GHCV
Sbjct: 2629 YKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVS 2688
Query: 3813 SELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECK 3850
G+ + S E D + P+ Y ECK
Sbjct: 2689 GMGMGRGNPE-PPVSGEMDDNSLSPEACY------ECK 2719
Score = 47.0 bits (110), Expect = 4e-04
Identities = 107/498 (21%), Positives = 163/498 (32%), Gaps = 162/498 (32%)
Query: 27 ECDSAHFRCGSGHCI--PADWRCD---------GTKDCSDDADEIG----CAVVTCQQ-- 69
EC CG+G C+ P +RC+ K C +D DE C TC
Sbjct: 1407 ECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKAC-EDIDECSLPNICVFGTCHNLP 1465
Query: 70 GYFKCQSE-GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCI--PSEYR 126
G F+C+ E G + S +C D ++ C T TC +G C+ P Y
Sbjct: 1466 GLFRCECEIGYELDRS-----GGNCTDVNE----CLDPT------TCISGNCVNTPGSYI 1510
Query: 127 CDHVRDCPDGADENDCQYPTCEQLTCDNGACY--------NTSQKCDWKVDCRDSSDEIN 178
CD CP + N + + + G CY N C ++ S
Sbjct: 1511 CD----CPPDFELNPTRVGCVDTRS---GNCYLDIRPRGDNGDTACSNEIGVGVSKASCC 1563
Query: 179 CT---------EIC-----LHNEFSCGNGECI---PRAYVCDHDNDCQD--GSDEHACNY 219
C+ E+C + C GE P + + ++CQ+ G +
Sbjct: 1564 CSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCI 1623
Query: 220 PTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCES----GPHDVHK--------CS 267
T G +Q CP+G Y N +D + D + CE+ GP + C
Sbjct: 1624 NTFGSFQCRCPTG--YYLN------EDTRVCDDVNECETPGICGPGTCYNTVGNYTCICP 1675
Query: 268 PREWSCPESGRCISIYK------------VCDGIL------------------------D 291
P C+ + + CDG L
Sbjct: 1676 PDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQ 1735
Query: 292 CPGREDENNTSTGKYCSMTLCSALNCQY-------------QCHETP---YGGACF---- 331
CP ST ++ TLC + + +C E P G C
Sbjct: 1736 CP------IPSTDEFA--TLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVG 1787
Query: 332 -----CPPGYIINHNDSRTCVEFDDCQIWGICDQ--KCESRPGRHLCHCEEGYILERGQY 384
CP G+ N + C + D+CQ +C + +C + G + C C+ GY
Sbjct: 1788 SFRCECPVGFFYN-DKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQ 1846
Query: 385 CKANDSFGEASIIFSNGR 402
C + E I S+G+
Sbjct: 1847 CNDRNECQEIPNICSHGQ 1864
Score = 43.9 bits (102), Expect = 0.004
Identities = 90/447 (20%), Positives = 145/447 (32%), Gaps = 145/447 (32%)
Query: 52 DCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSH 111
+C+ D D + +G +KC +C+ + D D ++ C +
Sbjct: 726 ECALDPDICPNGICENLRGTYKC-----------ICNSGYEVDSTGKNCVDINE--CVLN 772
Query: 112 QITCSNGQC--IPSEYRCDHVRDCPDG----ADENDCQ-YPTCEQLTCDNGACYNT--SQ 162
+ C NGQC P + C CP G D C+ CE C NG C N+ S
Sbjct: 773 SLLCDNGQCRNTPGSFVCT----CPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSF 828
Query: 163 KCDWKVDCR---------------------DSSDEINCTEICLHNEFS------------ 189
C+ + D EIN L ++
Sbjct: 829 ICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCT 888
Query: 190 -------CGNGECIPRAYVCDHDNDCQ--DGSDEHACNYPTCGGYQFTCPSGRCI----- 235
CG G + C+ ++C+ G ++ T G ++ CPSG +
Sbjct: 889 LCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGR 948
Query: 236 -------------YQNWVCD--------------------GEDDCKD------NGDEDGC 256
Y++ C G ++C++ E+ C
Sbjct: 949 ICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELC 1008
Query: 257 ESGP--------------HDVHKCSPREWSCPESGRC---ISIYKV-CDG--ILDCPGRE 296
GP D+++C C G+C I +K CD LD
Sbjct: 1009 PRGPGFATKEITNGKPFFKDINECKMIPSLCTH-GKCRNTIGSFKCRCDSGFALD----S 1063
Query: 297 DENNTSTGKYCSMT--LCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQI 354
+E N + C ++ LC + QC TP C C GY + C++ D+CQ
Sbjct: 1064 EERNCTDIDECRISPDLCG----RGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQR 1119
Query: 355 WGICDQ--KCESRPGRHLCHCEEGYIL 379
+ + C + G + C C G+ L
Sbjct: 1120 DPLLCRGGVCHNTEGSYRCECPPGHQL 1146
Score = 42.7 bits (99), Expect = 0.008
Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 1375 CPLGFLLANDSKTCEDIDECDILGSCSQ--HCYNMRGSFRCSCDTGYMLESDGRTCK 1429
C GF+ + C+D+DEC + Q +C N GSF C C G+ L + C+
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCE 287
Score = 42.4 bits (98), Expect = 0.011
Identities = 72/307 (23%), Positives = 108/307 (35%), Gaps = 64/307 (20%)
Query: 125 YRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN----TSQKCDWKVDCRDSSDEINCT 180
Y C + P G N C P C +C +G C T C S + +C
Sbjct: 66 YCCPGWKTLPGG---NQCIVPICRH-SCGDGFCSRPNMCTCPSGQIAPSCGSRSIQ-HCN 120
Query: 181 EICLHNEFSCGNGECI-PRAYVCDH------DNDCQDGSDEHACNYPTCGGYQFTCP--- 230
C+ N SC + C+ + Y+ H ++ C +G A N C Y FT P
Sbjct: 121 IRCM-NGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACT-YGFTGPQCE 178
Query: 231 ----SGRC--IYQNWVCDGEDD---------CKDNGDEDG--CESGPHDVHKC------S 267
+G C + N +C G+ C G G CE P H C +
Sbjct: 179 RDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPN 238
Query: 268 PREWSCPESGRCISIYKVCDG----------ILDCPGREDENNTSTGKYCSMTLCSALN- 316
R +C + C +I +C G CP N S K + CS +
Sbjct: 239 IRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQ-KCEDIDECSTIPG 297
Query: 317 -CQY-QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW-----GICDQKCESRPGRH 369
C+ +C T C CPPG+ + + +R C++ + G C + +
Sbjct: 298 ICEGGECTNTVSSYFCKCPPGFYTSPDGTR-CIDVRPGYCYTALTNGRCSNQLPQSITKM 356
Query: 370 LCHCEEG 376
C C+ G
Sbjct: 357 QCCCDAG 363
Score = 40.8 bits (94), Expect = 0.032
Identities = 75/313 (23%), Positives = 103/313 (32%), Gaps = 62/313 (19%)
Query: 1132 NDCGDGSDEK----NCNSTE---TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCV 1184
+ CGDG + C S + +C N RC++ D C G +G
Sbjct: 87 HSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGY--IGTH 144
Query: 1185 LNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEF-QCQEDGI- 1242
+ C +G +C+ NRC + + E T P S++ Q Q GI
Sbjct: 145 CGQPVCESGCLNGGRCVA-PNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIV 203
Query: 1243 -----CIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCG 1297
C GHP C + CP+ C G + R C
Sbjct: 204 CTKTLCCATVGRAWGHP-----------C--EMCPAQPHPCRRGFIPNI-----RTGACQ 245
Query: 1298 DMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDC--PNG---TDESPLCNG-N 1351
D+ + C + C G N C+N G F+C P G + S C +
Sbjct: 246 DVDE----------CQAIPGLCQGGN-CINTV----GSFECKCPAGHKLNEVSQKCEDID 290
Query: 1352 SCSDFNGGCTH-ECVQEPFGAKCLCPLGFLLANDSKTCEDI--DECDIL---GSCSQHCY 1405
CS G C EC C CP GF + D C D+ C G CS
Sbjct: 291 ECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLP 350
Query: 1406 NMRGSFRCSCDTG 1418
+C CD G
Sbjct: 351 QSITKMQCCCDAG 363
Score = 37.7 bits (86), Expect = 0.27
Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 16/84 (19%)
Query: 4327 NKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHG 4386
N+ + +C+ C RP C CP G C + N+ RCM+G
Sbjct: 78 NQCIVPICRHSCGDGFCSRPN--MCTCPSGQI-----APSCGSRSIQHCNI----RCMNG 126
Query: 4387 GNCYFDETDLPKCKCPSGYTGKYC 4410
G+C D C C GY G +C
Sbjct: 127 GSCSDDH-----CLCQKGYIGTHC 145
Score = 37.4 bits (85), Expect = 0.35
Identities = 47/199 (23%), Positives = 69/199 (34%), Gaps = 48/199 (24%)
Query: 3464 IVSNPCGT--NNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCAN 3521
I +N C + N G +C PG FTCEC F +L +GS+ C
Sbjct: 2523 IDNNECTSDINLCGSKGICQNTPGS--FTCECQRGF-SLDQTGSS-----CEDVD----- 2569
Query: 3522 NEKCIPIWWKCDGQKDCSDGSDEL-----ALCPQRFCRLGQF-QCSDGNCTSPQTLCNAH 3575
+C+G C G + CPQ + + Q+ QC D N +C
Sbjct: 2570 ---------ECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGG- 2619
Query: 3576 QNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRT- 3634
+C + + +C A + S C N+C S C++
Sbjct: 2620 ASCHNTLGSYKCMCP-----------AGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEG 2668
Query: 3635 -----CRPGQFRCANGRCI 3648
C PG FR G C+
Sbjct: 2669 GYLCGCPPGYFRIGQGHCV 2687
Score = 35.8 bits (81), Expect = 1.0
Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 9/53 (16%)
Query: 2018 SSNGCSNNMNACQQI--------CLPVPGGLFSCACATGFKLNPDNRSCSPYN 2062
+S G N+ N CQ+I C+ G F C C TGFK N D C N
Sbjct: 1842 TSTGQCNDRNECQEIPNICSHGQCIDTVGS-FYCLCHTGFKTNDDQTMCLDIN 1893
Score = 34.7 bits (78), Expect = 2.3
Identities = 15/38 (39%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 2022 CSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCS 2059
CS C+ C G + C+C GF L PD RSC+
Sbjct: 1201 CSIMNGGCETFCTNSEGS-YECSCQPGFALMPDQRSCT 1237
Score = 34.7 bits (78), Expect = 2.3
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 6/42 (14%)
Query: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
C NGGCE C T+++G + C C GF L D+R C
Sbjct: 1201 CSIMNGGCETFC-----TNSEG-SYECSCQPGFALMPDQRSC 1236
Score = 34.7 bits (78), Expect = 2.3
Identities = 28/129 (21%), Positives = 48/129 (37%), Gaps = 1/129 (0%)
Query: 2006 GLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFI 2065
G + H + + S N N C+ G F C C G+++ PD R+C N +
Sbjct: 1919 GFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECL 1978
Query: 2066 VVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIR 2125
+ A G L + P +N D+D C + ++ + +
Sbjct: 1979 LEPRKCA-PGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFK 2037
Query: 2126 RIKPDGSSL 2134
+ P+G SL
Sbjct: 2038 CLCPEGFSL 2046
Score = 34.3 bits (77), Expect = 3.0
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 2022 CSNNMNACQQ-ICLPVPGGLFSCACATGFKLNPDNRSC 2058
CS N+N C CL PGG + C C GF + D ++C
Sbjct: 1408 CSENLNLCGNGQCLNAPGG-YRCECDMGFVPSADGKAC 1444
Score = 34.3 bits (77), Expect = 3.0
Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 2019 SNGCSNNMNAC--QQICLPVPGGLFSCACATGFKLNPDNRSC 2058
+N C++++N C + IC PG F+C C GF L+ SC
Sbjct: 2525 NNECTSDINLCGSKGICQNTPGS-FTCECQRGFSLDQTGSSC 2565
Score = 34.3 bits (77), Expect = 3.0
Identities = 23/78 (29%), Positives = 33/78 (42%), Gaps = 10/78 (12%)
Query: 4332 NLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYF 4391
NLC +C PG ++C C +G S ++ + + C+ E N RC HG
Sbjct: 2533 NLCGS--KGICQNTPGSFTCECQRGFS-LDQTGSSCEDVDECEGN----HRCQHGCQNII 2585
Query: 4392 DETDLPKCKCPSGYTGKY 4409
+C CP GY Y
Sbjct: 2586 GGY---RCSCPQGYLQHY 2600
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 112 bits (280), Expect = 9e-24
Identities = 122/497 (24%), Positives = 180/497 (36%), Gaps = 84/497 (16%)
Query: 980 PNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC--EGDPTN-EPPTEQCGLFSFPCKNG 1036
P C H C C C G L + TC EG P E P E F
Sbjct: 612 PGELCQHLCINTVGSYH-CACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVAS 670
Query: 1037 RCVPNYYLCDGVDDCHDNSD-EQLCGTLNNTCSSSAF----------TC-GHGECIPAHW 1084
+P + C DN +Q+C T+ + S F +C EC+
Sbjct: 671 NTIP--LPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAH 728
Query: 1085 RCDKRNDCVDGSDEHNCPTH----APASCLDTQYTC-DNHQCISKNWVCDTDNDCGDGSD 1139
C +R CV+ C H A L+ C D ++C++ C C +
Sbjct: 729 DCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLG 788
Query: 1140 EKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDK 1199
+C TC+P + + C D+ G C + G + T F C + +
Sbjct: 789 SFHCYKALTCEPG-YALKDGECEDVDECAMGTHTC-----QPGFLCQNTKGSFYCQARQR 842
Query: 1200 CIG-----VTNRCDGVFDCSDNSDEAGCPTRPPGMCHSD--EFQCQEDG-ICIPNFWECD 1251
C+ C + +C+ S+ P RP C + + CQ + IC +
Sbjct: 843 CMDGFLQDPEGNCVDINECTSLSE----PCRPGFSCINTVGSYTCQRNPLICARGY---- 894
Query: 1252 GHPDCLYGSDEHNACVP-KTCPSSYFHCDNGNCIHR---AWLCD------RDNDCGDMSD 1301
+ SD+ CV C + C G H ++ CD RD D
Sbjct: 895 ------HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 948
Query: 1302 EKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNG--- 1358
+C P R L + C N G + C + +G C D N
Sbjct: 949 VNECWASPGR--------LCQHTCENTL----GSYRCSCASGFLLAADGKRCEDVNECEA 996
Query: 1359 -GCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDEC----DILGSCSQHCYNMRGSFRC 1413
C+ EC +C C G+ LA D TC DIDEC IL C+ C N+ GS++C
Sbjct: 997 QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL--CTFRCLNVPGSYQC 1054
Query: 1414 SC-DTGYMLESDGRTCK 1429
+C + GY + ++GR+CK
Sbjct: 1055 ACPEQGYTMTANGRSCK 1071
Score = 103 bits (257), Expect = 4e-21
Identities = 107/384 (27%), Positives = 142/384 (36%), Gaps = 72/384 (18%)
Query: 2821 TCQSGYT------KCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG 2874
+C GY C + + C+ + C C + YC HT CA G
Sbjct: 703 SCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGS--FYCVNHTVL-----CADG 755
Query: 2875 RCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGG-RCIPSEWICDGDNDCGD 2933
+ H C +C + H T F C C P + DG+ C D
Sbjct: 756 YILNAHRKCVDINECVTDLHTCSRGEHCVNTL--GSFHCYKALTCEPGYALKDGE--CED 811
Query: 2934 MSD-EDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGY--DENQNCTR 2990
+ + H CQ FLC N + S+ C C DG+ D NC
Sbjct: 812 VDECAMGTHTCQ------PGFLCQNTKG--------SFYCQARQRCMDGFLQDPEGNCV- 856
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
NE T C P F C N G Y TCQ+N C G S
Sbjct: 857 ---DINECTSLSEPCRPG-FSCI--NTVGSY---------TCQRNPLICARGYHASDDGT 901
Query: 3051 -CDEDNDCGDGSDELMHLCHTPEPTCP--PHEFKCDNGRCIEMMKLCNHLDDCLDNSDEK 3107
C + N+C G +H C + C P ++CD C + C+D
Sbjct: 902 KCVDVNECETG----VHRCGEGQ-VCHNLPGSYRCD---CKAGFQRDAFGRGCID----- 948
Query: 3108 GCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKC 3167
+NEC C H C +TL S+ CSC G+ L +D + C D++EC CSQ+C
Sbjct: 949 ---VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQEC 1003
Query: 3168 ENVIGSYICKCAPGYLREPDGKTC 3191
N+ GSY C C GY DG TC
Sbjct: 1004 ANIYGSYQCYCRQGYQLAEDGHTC 1027
Score = 90.1 bits (222), Expect = 5e-17
Identities = 103/428 (24%), Positives = 153/428 (35%), Gaps = 88/428 (20%)
Query: 2780 CNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRV 2839
C E + C R+F N + + + N + C D + + KC + N C+ +
Sbjct: 717 CEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHT--VLCADGYILNAHRKCVDINECVTDL 774
Query: 2840 YLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG-RCIPQHWYCDQETDCFDASDEPAS 2898
+ C C +T S F C C P Y ++ +C D +
Sbjct: 775 HTCSRGEHC------------VNTLGS--FHCYKALTCEP--GYALKDGECEDVDE---- 814
Query: 2899 CGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQN-CSDSEFLCVN 2957
C TC F C + + C C D +D C + N C+ C
Sbjct: 815 CAMGTHTC-QPGFLCQNTK---GSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPC-- 868
Query: 2958 DRPPDRRCIPQ--SWVCD-GDVDCTDGYDENQNCTR----RTCSENEFTCGYG-LC--IP 3007
P CI S+ C + C GY + + T+ C CG G +C +P
Sbjct: 869 --RPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLP 926
Query: 3008 KIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHL 3067
+RCD + RGC+ + N+C L
Sbjct: 927 GSYRCDCKAGFQRDAFGRGCI------------------------DVNECWASPGRLCQ- 961
Query: 3068 CHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC-GINECHDPSISGCDHNC 3126
HT E T + C +G + +D K C +NEC C C
Sbjct: 962 -HTCENTLGSYRCSCASGFLLA--------------ADGKRCEDVNEC---EAQRCSQEC 1003
Query: 3127 TDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE-MPFVCSQKCENVIGSYICKC-APGYLR 3184
+ S+ C CR GY+L D TC DIDEC + +C+ +C NV GSY C C GY
Sbjct: 1004 ANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTM 1063
Query: 3185 EPDGKTCR 3192
+G++C+
Sbjct: 1064 TANGRSCK 1071
Score = 85.5 bits (210), Expect = 1e-15
Identities = 116/449 (25%), Positives = 160/449 (35%), Gaps = 64/449 (14%)
Query: 3607 IPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
+P S D ++C E H T G + CA C P D C
Sbjct: 596 LPNSLPGDDQDECLLLPGELCQHLCINTV--GSYHCA---CFPGFSLQDDGRTCRPEGHP 650
Query: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFR 3726
P E L F++ + T +P+ + C+DN G ++ C VG
Sbjct: 651 PQPEAPQEPALKSEFSQVASNTIPLPLPQ------PNTCKDN----GPCKQVCSTVGGSA 700
Query: 3727 CKNHHCIP-LRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCG 3785
+ C P DG + C D DE +C+ +F CVN + S + +H C
Sbjct: 701 ICS--CFPGYAIMADGVS-CEDQ-DECLMGAHDCSRRQF-CVNT--LGSFYCVNHTVLCA 753
Query: 3786 D----NSDERDCEMRTCHPEYFQCTSG-HCVHSELKCDGSADCLDASDEADCPTRFPDGA 3840
D N+ + ++ C + C+ G HCV++ GS C A + DG
Sbjct: 754 DGYILNAHRKCVDINECVTDLHTCSRGEHCVNTL----GSFHCYKALT-CEPGYALKDGE 808
Query: 3841 YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH 3900
H C P + C G + C+D P D N C
Sbjct: 809 CEDVDECAMGTHTCQPGFL-CQNTK--GSFYCQARQRCMDGFLQDPEGNCVDINECTSLS 865
Query: 3901 EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL 3960
E C C + C C G+ + DD C D ++
Sbjct: 866 EPCRPGFSCINTVGSYT----------CQRNPLICARGY-----HASDDGTKCVDVNE-- 908
Query: 3961 GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINEC--EQFGTCP 4018
C G R C E Q C L G + C C AGF+ + F R C+D+NEC C
Sbjct: 909 -CETGVHR-CGEG---QVCHNL-PGSYRCDCKAGFQRDAFGR-GCIDVNECWASPGRLCQ 961
Query: 4019 QHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
C NT GSY C CA GF +D GKRC
Sbjct: 962 HTCENTLGSYRCSCASGFLLAAD--GKRC 988
Score = 82.8 bits (203), Expect = 7e-15
Identities = 102/411 (24%), Positives = 134/411 (32%), Gaps = 93/411 (22%)
Query: 2835 CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASD 2894
C P L D C SEF + IP Q C D
Sbjct: 631 CFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLP--LPQPNTCKDNGP 688
Query: 2895 EPASCGHSERTCLADEFK-----CDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCS 2949
C + + F DG C + G +DC +R C N S
Sbjct: 689 CKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCS------RRQFCVNTLGS 742
Query: 2950 DSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGY---------DENQNCTR-RTCSENEF- 2998
F CVN V C DGY D N+ T TCS E
Sbjct: 743 ---FYCVNHT----------------VLCADGYILNAHRKCVDINECVTDLHTCSRGEHC 783
Query: 2999 --TCGYGLCIPKIFRCD-----RHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVC 3051
T G C K C+ + +C D DE TCQ F CQN + +F C
Sbjct: 784 VNTLGSFHCY-KALTCEPGYALKDGECEDV-DECAMGTHTCQPG-FLCQNTK---GSFYC 837
Query: 3052 DEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC-- 3109
C DG PE C D C + + C C++ C
Sbjct: 838 QARQRCMDG------FLQDPEGNC------VDINECTSLSEPCRPGFSCINTVGSYTCQR 885
Query: 3110 -------------------GINECHDPSISGCDHN--CTDTLTSFYCSCRPGYKLMSDKR 3148
+NEC + + C C + S+ C C+ G++ + R
Sbjct: 886 NPLICARGYHASDDGTKCVDVNEC-ETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGR 944
Query: 3149 TCVDIDECTEMPF-VCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
C+D++EC P +C CEN +GSY C CA G+L DGK C + E
Sbjct: 945 GCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECE 995
Score = 80.1 bits (196), Expect = 5e-14
Identities = 93/396 (23%), Positives = 145/396 (36%), Gaps = 61/396 (15%)
Query: 3685 SCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNH-------HCIPLRW 3737
SC Y + C D+C + + + + +G F C NH + +
Sbjct: 703 SCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHR 762
Query: 3738 QCDGQNDCGDNSDEENCAPRE-C--TESEFRCVNQ-QCIPSRWICDHYNDCGDNSDERDC 3793
+C N+C +D C+ E C T F C C P + D G+ D +C
Sbjct: 763 KCVDINECV--TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD-----GECEDVDEC 815
Query: 3794 EM--RTCHPEYF-QCTSG--HCVHSELKCDG-----SADCLDASDEADCPTRFPDGAYCQ 3843
M TC P + Q T G +C + DG +C+D ++ G C
Sbjct: 816 AMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCI 875
Query: 3844 ATM--FECKNH--VCIPPYWKCDGDDDCGDGSDEE--LHLCLD--VPCNSPNRFRCDNNR 3895
T+ + C+ + +C Y D C D ++ E +H C + V N P +RCD
Sbjct: 876 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKA 935
Query: 3896 CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNV-CDDADDCG 3954
G D + C+ Y C +G + D C+D ++C
Sbjct: 936 GFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC- 994
Query: 3955 DWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQF 4014
C Q C + G + C C G++ D +C DI+EC Q
Sbjct: 995 ----------------EAQRCSQECANIY-GSYQCYCRQGYQL-AEDGHTCTDIDECAQG 1036
Query: 4015 G--TCPQHCRNTKGSYECVCAD-GFTSMSDRPGKRC 4047
C C N GSY+C C + G+T ++ G+ C
Sbjct: 1037 AGILCTFRCLNVPGSYQCACPEQGYTMTAN--GRSC 1070
Score = 75.9 bits (185), Expect = 9e-13
Identities = 89/411 (21%), Positives = 156/411 (37%), Gaps = 75/411 (18%)
Query: 41 IPADWRCDGTKDCSDDADEIG-CAVVTCQQGY------FKCQSEGQCIPNSWVCDQDQDC 93
+P C C +G A+ +C GY C+ + +C+ + C + Q C
Sbjct: 677 LPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFC 736
Query: 94 DDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ---------- 143
+ C +H + C++G + + +C + +C D + C
Sbjct: 737 VN------TLGSFYCVNHTVLCADGYILNAHRKCVDINECV--TDLHTCSRGEHCVNTLG 788
Query: 144 -YPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNE--FSCGNGECIPRAY 200
+ + LTC+ G + C+ +C + +C + + F C + +
Sbjct: 789 SFHCYKALTCEPGYALKDGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF 847
Query: 201 VCDHDNDCQDGSDEHACNYPTCGGYQF--TCPSGRCIYQNWVCDGEDDCKDNG----DED 254
+ D + +C D ++ + + P G+ T S C +C D+G D +
Sbjct: 848 LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVN 907
Query: 255 GCESGPHDVHKCSPRE--WSCPESGRCI--------SIYKVCDGILDC---PGREDENN- 300
CE+G VH+C + + P S RC + + C + +C PGR ++
Sbjct: 908 ECETG---VHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTC 964
Query: 301 -----------------TSTGKYCS-MTLCSALNCQYQCHETPYGGACFCPPGYIINHND 342
+ GK C + C A C +C C+C GY + D
Sbjct: 965 ENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-D 1023
Query: 343 SRTCVEFDDC-QIWGI-CDQKCESRPGRHLCHC-EEGYIL-ERGQYCKAND 389
TC + D+C Q GI C +C + PG + C C E+GY + G+ CK D
Sbjct: 1024 GHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1074
Score = 61.6 bits (148), Expect = 2e-08
Identities = 117/501 (23%), Positives = 177/501 (35%), Gaps = 111/501 (22%)
Query: 2653 NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLA------------------NNRKHCIV 2694
N C+ NG C +C+ A C C G +A + R+ C+
Sbjct: 681 NTCKD-NGPCKQVCSTVGGSAICSC-FPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVN 738
Query: 2695 DNGE-RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRC 2753
G C + C++G ++ KC + N+C V LHTCS C N
Sbjct: 739 TLGSFYCVNHTVLCADGYILNAHRKCVDINEC---------VTDLHTCS-RGEHCVNTLG 788
Query: 2754 VQYSYR---CD--YYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHD 2808
+ Y+ C+ Y G+ D C F+C N + F C C D
Sbjct: 789 SFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTK---GSFYCQARQRCMD 845
Query: 2809 NNTSD-EKNCPD-RTCQSGYTKCHNSNICIPRV--YLCDGDN---DCGDNSDENPTYCT- 2860
D E NC D C S C CI V Y C + G ++ ++ T C
Sbjct: 846 GFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVD 905
Query: 2861 THTCSSSEFQCASGRC---IPQHWYCDQET---------DCFDASDEPASCGH-SERTC- 2906
+ C + +C G+ +P + CD + C D ++ AS G + TC
Sbjct: 906 VNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCE 965
Query: 2907 -LADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRC 2965
++C C + C D+ ++C+ Q CS C N
Sbjct: 966 NTLGSYRCS---CASGFLLAADGKRCEDV------NECEAQRCSQE---CAN-------- 1005
Query: 2966 IPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYS--- 3022
I S+ C C GY ++ TC++ + C G I FRC N G Y
Sbjct: 1006 IYGSYQC----YCRQGYQLAED--GHTCTDID-ECAQGAGILCTFRC--LNVPGSYQCAC 1056
Query: 3023 DERGCLYQTCQQNQFTCQN-GRCISKTFVCDEDNDCGD--GSDELMHLCHTPEPTCPPH- 3078
E+G T N +C++ C T C E C + GS + CPP+
Sbjct: 1057 PEQG---YTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF------ECPPNY 1107
Query: 3079 ----EFKCDNGRCIEMMKLCN 3095
+ KC+ C + ++ N
Sbjct: 1108 VQVSKTKCERTTCHDFLECQN 1128
Score = 56.2 bits (134), Expect = 7e-07
Identities = 82/352 (23%), Positives = 124/352 (35%), Gaps = 94/352 (26%)
Query: 36 GSGHCIPADWRCD---GTKDCS-DDADEIGCAVVTCQQGY--------FKCQS------- 76
GS HC A C+ KD +D DE TCQ G+ F CQ+
Sbjct: 788 GSFHCYKA-LTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDG 846
Query: 77 -----EGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSE-YRCDHV 130
EG C+ + + C G TC + + C+ G + +C V
Sbjct: 847 FLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDV 906
Query: 131 RDCPDGADENDCQYPTCEQLTCDNG-ACYNT--SQKCDWKVDCRDSSDEINCTEICLHNE 187
+C G C G C+N S +CD K + + C ++ NE
Sbjct: 907 NECETGVHR------------CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDV---NE 951
Query: 188 FSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDC 247
G +C H C++ T G Y+ +C SG + DG+
Sbjct: 952 CWASPGR------LCQHT--CEN----------TLGSYRCSCASGFLL----AADGKR-- 987
Query: 248 KDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYC 307
CE DV++C + S C +IY G C R+ G C
Sbjct: 988 --------CE----DVNECEAQRCS----QECANIY----GSYQCYCRQGYQLAEDGHTC 1027
Query: 308 S-MTLCS---ALNCQYQCHETPYGGACFCPP-GYIINHNDSRTCVEFDDCQI 354
+ + C+ + C ++C P C CP GY + N R+C + D+C +
Sbjct: 1028 TDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTAN-GRSCKDVDECAL 1078
Score = 53.1 bits (126), Expect = 6e-06
Identities = 31/102 (30%), Positives = 40/102 (39%), Gaps = 32/102 (31%)
Query: 3122 CDHNCTDTLTSFYCSCRPGYKLMSDKRTC-----VDIDECTEMPFV-------------- 3162
C H C +T+ S++C+C PG+ L D RTC E + P +
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 3163 -------------CSQKCENVIGSYICKCAPGYLREPDGKTC 3191
C Q C V GS IC C PGY DG +C
Sbjct: 676 PLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSC 717
Score = 47.4 bits (111), Expect = 3e-04
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 3152 DIDECTEMPF-VCSQKCENVIGSYICKCAPGYLREPDGKTCR 3192
D DEC +P +C C N +GSY C C PG+ + DG+TCR
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCR 645
Score = 45.1 bits (105), Expect = 0.002
Identities = 21/43 (48%), Positives = 28/43 (65%), Gaps = 2/43 (4%)
Query: 1389 EDIDECDIL-GSCSQH-CYNMRGSFRCSCDTGYMLESDGRTCK 1429
+D DEC +L G QH C N GS+ C+C G+ L+ DGRTC+
Sbjct: 603 DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCR 645
Score = 35.4 bits (80), Expect = 1.3
Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 1/32 (3%)
Query: 2029 CQQICLPVPGGLFSCACATGFKLNPDNRSCSP 2060
CQ +C+ G + CAC GF L D R+C P
Sbjct: 616 CQHLCINTVGS-YHCACFPGFSLQDDGRTCRP 646
Score = 33.9 bits (76), Expect = 3.9
Identities = 22/76 (28%), Positives = 29/76 (38%), Gaps = 22/76 (28%)
Query: 4336 QICSHLCLLRPGGYSCACPQGSSF--------IEGSTTECDAAIE--------------L 4373
++C HLC+ G Y CAC G S EG + +A E +
Sbjct: 614 ELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTI 673
Query: 4374 PINLPPPCRCMHGGNC 4389
P+ LP P C G C
Sbjct: 674 PLPLPQPNTCKDNGPC 689
Score = 32.7 bits (73), Expect = 8.6
Identities = 44/183 (24%), Positives = 65/183 (35%), Gaps = 46/183 (25%)
Query: 47 CDGTKDCSDDADEIGCAVVTC-QQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQ 105
C ++C ++A E G TC QQG C EG Q DC G R
Sbjct: 38 CPPLENCIEEALEPGACCATCVQQG---CACEGY---------QYYDCLQGGFVRGRVPA 85
Query: 106 STCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCD 165
S+ + + +C CP G + CQ+ C +L C
Sbjct: 86 G--QSYFVDFGSTEC-----------SCPPGGGKISCQFMLCPEL----------PPNCI 122
Query: 166 WKVDCRDSSDEINCTEI-CLH--NEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC-NYPT 221
V DS + C ++ C+H ++++ G+ +P C C D E C P
Sbjct: 123 EAVVVADSCPQ--CGQVGCVHAGHKYAAGHTVHLPPCRAC----HCPDAGGELICYQLPG 176
Query: 222 CGG 224
C G
Sbjct: 177 CHG 179
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 109 bits (272), Expect = 7e-23
Identities = 140/604 (23%), Positives = 218/604 (36%), Gaps = 98/604 (16%)
Query: 2655 CEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCS-NGRC 2712
C++ G C++ +C C+CP ++ N + ++ + C C N C
Sbjct: 1812 CKEIPGICANGVCINQIGSFRCECPTGFSY----NDLLLVCEDIDECSNGDNLCQRNADC 1867
Query: 2713 ISE--EWKCDNDNDCGDGSDEMESVCAL--HTCSPTAFTCANGRCV--QYSYRCDYYNDC 2766
I+ ++C+ C G + + + C C++G CV Q SY+C +N
Sbjct: 1868 INSPGSYRCE----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923
Query: 2767 GDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICN-----GVDNCHDNNTSDEKNCPD-- 2819
D+ C+ D + C N C N G + H+N+ D C
Sbjct: 1924 KASQDQTMCM--DVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFF 1981
Query: 2820 -RTCQSGYTKCHNSN-----ICIPRVYLCDGDNDCGDNSD--ENPTYCTTHTCSSSEFQC 2871
+ C++G +C N +C L +C D ++ P C+ TC + E
Sbjct: 1982 GQVCRNG--RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLE--- 2036
Query: 2872 ASGRCIPQHWYCDQETDCFDASD---EPASCGHSERTCLADEFKCDGGRCIPSEWICDGD 2928
S RCI Y + +C D ++ +P C T F+C C P + D
Sbjct: 2037 GSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQC---LCPPGFVLSDNG 2093
Query: 2929 NDCGDMSDEDKRHQCQNQNCSDSEFL-------CVNDRP------PDRRCIPQSWVCDGD 2975
C D +N CS + C + P P C V D
Sbjct: 2094 RRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQD 2153
Query: 2976 VDCTDGYDE--NQNCTRRT---CSENEFTCGYGLCIPK--IFRCD------------RHN 3016
+ C G+ + + TR C E+ C G CI FRC+ R
Sbjct: 2154 L-CPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCV 2212
Query: 3017 DCGDYSDERGCLYQTCQQN----QFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPE 3072
D + S C TC + C G C++ N+C C
Sbjct: 2213 DTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMN-- 2270
Query: 3073 PTCPPHEFKCDNGRCI-EMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLT 3131
T +E C G + E K+C LD+C + G+++C + C + +
Sbjct: 2271 -TFGSYECTCPIGYALREDQKMCKDLDECAE-------GLHDCESRGMM-----CKNLIG 2317
Query: 3132 SFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQ-KCENVIGSYICKCAPGYLREPDGKT 3190
+F C C PG D CVD +EC P +C +C N+IGSY C+C G+ G
Sbjct: 2318 TFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTE 2377
Query: 3191 CRQN 3194
C N
Sbjct: 2378 CLDN 2381
Score = 108 bits (270), Expect = 1e-22
Identities = 73/237 (30%), Positives = 107/237 (45%), Gaps = 36/237 (15%)
Query: 2978 CTDGYD---ENQNCTR-RTCSENEFTCGYGLCI--PKIFRCDRHNDC-GDYSDERGCL-Y 3029
C G+ E +NCT C + CG G+C+ P F C+ + + C+
Sbjct: 1100 CNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDI 1159
Query: 3030 QTCQQNQFTCQNGRCISK--TFVCD---------EDNDCGDGSDELMHLCHTPEPTCPPH 3078
C++N C+ G C++ +F CD DC D ++ C
Sbjct: 1160 DECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINE------------CSLS 1207
Query: 3079 EFKCDNGRCIEMMKL--CNHLDDCLDNSDEKGC-GINECHDPSISGCDHNCTDTLTSFYC 3135
+ C NG+C+ M+ C+ D +GC I+EC + GCD CT++ S+ C
Sbjct: 1208 DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN-GGCDTQCTNSEGSYEC 1266
Query: 3136 SCRPGYKLMSDKRTCVDIDECTEMPFVC-SQKCENVIGSYICKCAPGYLREPDGKTC 3191
SC GY LM D R+C DIDEC P +C +C N+ G Y C C G++ D KTC
Sbjct: 1267 SCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Score = 108 bits (270), Expect = 1e-22
Identities = 161/650 (24%), Positives = 224/650 (34%), Gaps = 166/650 (25%)
Query: 2663 SHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDND 2722
S IC P EC+C EG K+C+ + + C + C G C++ E D
Sbjct: 1128 SGICVNTPGSFECEC-FEGYESGFMMMKNCM--DIDECERNPLLCRGGTCVNTEGSFQCD 1184
Query: 2723 NDCG-DGSDEMESVCALHTCSPTAFTCANGRCVQY--SYRCDYYNDCGDGSDEAGCLFRD 2779
G + S E ++ CS + C NG+CV +Y+C D GC D
Sbjct: 1185 CPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDID 1244
Query: 2780 ----CNATTEFMCNNRR------------CIPREFICNGVDNCHDN----------NTSD 2813
N + C N +P C +D C +N N
Sbjct: 1245 ECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPG 1304
Query: 2814 EKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCAS 2873
E C C G+ + CI N+C D N C C +++ S
Sbjct: 1305 EYRC---LCYDGFMASMDMKTCIDV-------NEC----DLNSNICMFGECENTK---GS 1347
Query: 2874 GRCIPQHWYCDQE--TDCFDASDEPASCGHS---ERTCL--ADEFKCDGGRCIPSEWICD 2926
C Q Y ++ T C D DE H+ +CL FKC WI +
Sbjct: 1348 FICHCQLGYSVKKGTTGCTDV-DECEIGAHNCDMHASCLNIPGSFKCS----CREGWIGN 1402
Query: 2927 GDNDCGDMSD-EDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN 2985
G C D+ + + HQC CVN P RC C+D DE
Sbjct: 1403 GIK-CIDLDECSNGTHQCS------INAQCVNT-PGSYRCACSEGFTGDGFTCSD-VDE- 1452
Query: 2986 QNCTRRTCSENEFTCGYGLC--IPKIFRCDRHNDCGDYSDERGC------------LYQT 3031
C+EN C G C +P +RC+ SD R C ++ T
Sbjct: 1453 -------CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT 1505
Query: 3032 CQQN----QFTCQNGRCISKTFV-CDEDNDCGDGSDELMHLC-HTP---EPTCPPHEFKC 3082
C C +G + +T C + ++C D + + LC +TP E CPP +F+
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPP-DFQL 1564
Query: 3083 --------DN--GRCIEMMKLCNHLDDCLDNSDEKGCGI--------------NECHD-P 3117
DN G C +K D L + E G G+ N C P
Sbjct: 1565 NPTGVGCVDNRVGNCY--LKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCP 1622
Query: 3118 SISGCDH-----------------------------------NCTDTLTSFYCSCRPGYK 3142
++ ++ NC +T SF C C GY
Sbjct: 1623 PVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1682
Query: 3143 LMSDKRTCVDIDECTEMPFVCSQ-KCENVIGSYICKCAPGYLREPDGKTC 3191
L D R C DIDEC P VC C N +G+Y C C P Y++ G C
Sbjct: 1683 LSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC 1732
Score = 103 bits (258), Expect = 3e-21
Identities = 117/501 (23%), Positives = 189/501 (37%), Gaps = 94/501 (18%)
Query: 1000 CPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNS---- 1055
CP G A+ G P + E C F C G+C G C NS
Sbjct: 1052 CPRGAGFANRGDVLTGRPFYKDINE-CKAFPGMCTYGKCRNTI----GSFKCRCNSGFAL 1106
Query: 1056 --DEQLCGTLNNTCSSSAFTCGHGECI--PAHWRCDKRNDCVDGSDEHNCPTHAPASCLD 1111
+E+ C ++ C S CG G C+ P + C+ C +G + +C+D
Sbjct: 1107 DMEERNCTDIDE-CRISPDLCGSGICVNTPGSFECE----CFEG---YESGFMMMKNCMD 1158
Query: 1112 TQYTCDNHQCISKNWVC-DTDN----DCGDGSD----EKNCNSTETCQPSQFNCPNHRCI 1162
C+ + + + C +T+ DC G + ++C C S C N +C+
Sbjct: 1159 ID-ECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCV 1217
Query: 1163 DL----------SFVCDGDKDCVDGSDEV-----GCVLNCTASQ----FKCASGDKCIGV 1203
++ + D+ DE GC CT S+ C+ G +
Sbjct: 1218 NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPD 1277
Query: 1204 TNRCDGVFDCSDNSD--EAGCPTRPPG----MCHSDEFQCQEDGICIPNFWECDGHPD-C 1256
C + +C +N D + G T PG +C+ + CI + ECD + + C
Sbjct: 1278 GRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCI-DVNECDLNSNIC 1336
Query: 1257 LYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWL-CDRDNDCGDMSDEKDCPTQPFRCPSW 1315
++G E+ T S HC G + + C ++C + D P
Sbjct: 1337 MFGECEN------TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG- 1389
Query: 1316 QWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--------------CN------GNSCSD 1355
++C + + C + +C NGT + + C+ G +CSD
Sbjct: 1390 SFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSD 1449
Query: 1356 FNGGCTH-------ECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC-SQHCYNM 1407
+ + +C+ P +C C +GF A+DS++C+DIDEC C C N+
Sbjct: 1450 VDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNL 1509
Query: 1408 RGSFRCSCDTGYMLESDGRTC 1428
G F C CD GY L+ G C
Sbjct: 1510 PGMFHCICDDGYELDRTGGNC 1530
Score = 103 bits (256), Expect = 5e-21
Identities = 125/544 (22%), Positives = 192/544 (35%), Gaps = 117/544 (21%)
Query: 3536 KDCSDGSDELALCPQRFCR--LGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHH 3593
KD ++ +C CR +G F+C C S L +NC D +
Sbjct: 1072 KDINECKAFPGMCTYGKCRNTIGSFKC---RCNSGFALDMEERNCTDIDE---------- 1118
Query: 3594 CDSNEWQCANKRCI--PESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQ- 3650
C + C + C+ P S++C+ F E + C C G C+
Sbjct: 1119 CRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTE 1178
Query: 3651 -AWKCDVD---------NDCGDHSDEPIEECMSSAHLCDNFT--------EFSCKTNYRC 3692
+++CD DC D I EC S +LC N + SC Y+
Sbjct: 1179 GSFQCDCPLGHELSPSREDCVD-----INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233
Query: 3693 IPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRC---KNHHCIPLRWQCDGQNDCGDNS 3749
P C +D+C + GC+ + + G + C + + +P C ++C +N
Sbjct: 1234 TPDRQGCTDIDECMIMNG--GCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNP 1291
Query: 3750 DEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC-EMRTCHPEYFQCTSG 3808
D C +CT IP + C Y+ + D + C ++ C C G
Sbjct: 1292 DI--CDGGQCTN----------IPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFG 1339
Query: 3809 HCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCG 3868
C +++ GS C +CQ K C D+C
Sbjct: 1340 ECENTK----GSFIC-----------------HCQLGYSVKKGTT------GCTDVDECE 1372
Query: 3869 DGSDE-ELHL-CLDVPCNSPNRFRCDNNRCIYSHEV-CNGVDDCGDGTDETEEHCRKPTP 3925
G+ ++H CL++P F+C + + C +D+C +GT + C
Sbjct: 1373 IGAHNCDMHASCLNIP----GSFKCSCREGWIGNGIKCIDLDECSNGTHQ----CSINAQ 1424
Query: 3926 KPCTEYEYKCGNGHCIPHDN-VCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNE 3984
T Y+C D C D D+C + N+CE
Sbjct: 1425 CVNTPGSYRCACSEGFTGDGFTCSDVDECAE---------------NINLCENGQCLNVP 1469
Query: 3985 GGFICSCTAGFETNVFDRTSCLDINECEQFGTCP-QHCRNTKGSYECVCADGFTSMSDRP 4043
G + C C GF T D SC DI+EC C C N G + C+C DG+ DR
Sbjct: 1470 GAYRCECEMGF-TPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE--LDRT 1526
Query: 4044 GKRC 4047
G C
Sbjct: 1527 GGNC 1530
Score = 101 bits (251), Expect = 2e-20
Identities = 151/666 (22%), Positives = 241/666 (36%), Gaps = 154/666 (23%)
Query: 2653 NPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCI-VDNGERCGASSFTCSNG 2710
N C + CSH +C +C C H G + + ++ C+ VD ER + TC N
Sbjct: 1894 NECLEIPNVCSHGLCVDLQGSYQCIC-HNG-FKASQDQTMCMDVDECERHPCGNGTCKNT 1951
Query: 2711 ----RCISEE-WKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY--SYRC--- 2760
C+ ++ ++NDC D DE S C NGRC S++C
Sbjct: 1952 VGSYNCLCYPGFELTHNNDCLD-IDECSSFFGQ--------VCRNGRCFNEIGSFKCLCN 2002
Query: 2761 DYYNDCGDG-----SDEAGCLFRDCN-ATTEFMCNNRRCIPREFICNGVDNCHDNNTSDE 2814
+ Y DG ++E L C+ T + + + RCI +NC D N DE
Sbjct: 2003 EGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDE 2062
Query: 2815 KN--CPDRTCQS--GYTKCHNSNICIPRVYLCDGDNDCGDNSD-------ENPTYCTTHT 2863
C +C + G +C +C P L D C D EN
Sbjct: 2063 DPNICLFGSCTNTPGGFQC----LCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA 2118
Query: 2864 CSSSEFQCASGRCIPQHW-----YCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRC 2918
++++ +C + + W C ++ + A + GH L D + D C
Sbjct: 2119 FNTTKAKCCCSKMPGEGWGDPCELCPKDDEV--AFQDLCPYGHGTVPSLHDTRE-DVNEC 2175
Query: 2919 IPSEWICDGDNDCGDMSDEDKRHQCQ----------NQNCSDSEFLCVNDRPPDRRCIPQ 2968
+ S IC G + D +C+ C D++ + + + C
Sbjct: 2176 LESPGICSN----GQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCT-- 2229
Query: 2969 SWVCDGDVDCTDGYDEN--QNCTR-RTCSENEFTC-----------------GYGL---- 3004
+ + + +C +G++ NC C++N C GY L
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
Query: 3005 --------CIPKIFRCDRH-----NDCGDYS-----------DERGCLYQT-CQQNQFTC 3039
C + C+ N G + D GC+ + C+ C
Sbjct: 2290 KMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC 2349
Query: 3040 QNGRCI----SKTFVCDED-------NDCGDG------SDELMHLCHTPEPT---CPPHE 3079
+NGRC+ S C+E +C D ++ L +C + E
Sbjct: 2350 ENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSE 2409
Query: 3080 FKCDNGR-------------CIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNC 3126
CD GR + K+C H + G I+EC + C
Sbjct: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTD----GRDIDECKVMPNLCTNGQC 2465
Query: 3127 TDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREP 3186
+T+ SF C C+ GY +C+D+DEC++ P C+ C+N GSY C C GY+ +
Sbjct: 2466 INTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE 2525
Query: 3187 DGKTCR 3192
DGKTC+
Sbjct: 2526 DGKTCK 2531
Score = 97.1 bits (240), Expect = 4e-19
Identities = 140/594 (23%), Positives = 202/594 (34%), Gaps = 146/594 (24%)
Query: 2651 CNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNG 2710
C N F C+ PGP C+ +E A N C G+ TC G
Sbjct: 2228 CTNVIGSFECNCNEGFEPGPM-MNCEDINE----CAQNPLLCAFRCMNTFGSYECTCPIG 2282
Query: 2711 RCISEEWK-CDNDNDCGDGSDEMES--------------VCAL--------------HTC 2741
+ E+ K C + ++C +G + ES +C + C
Sbjct: 2283 YALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENEC 2342
Query: 2742 SPTAFTCANGRCVQY--SYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREF- 2798
C NGRCV SYRC+ C +G F+ ++ TE + N + E
Sbjct: 2343 RTKPGICENGRCVNIIGSYRCE----CNEG-------FQSSSSGTECLDNRQGLCFAEVL 2391
Query: 2799 --ICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNIC-IPRV------------YLCD 2843
IC + + T E C C G H +C +P Y D
Sbjct: 2392 QTICQMASSSRNLVTKSE--C---CCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTD 2446
Query: 2844 GDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQ--ETDCFDASDEPASCGH 2901
G + D P CT C ++ S RC + Y T C D + C
Sbjct: 2447 GRDI--DECKVMPNLCTNGQCINT---MGSFRCFCKVGYTTDISGTSCIDLDE----CSQ 2497
Query: 2902 SERTCLADEFKCDGG-RC-IPSEWICDGDND-CGDMSD-EDKRHQCQNQNCSDSEFLCVN 2957
S + C +G +C P ++ D C D+ + + K+H CQ FLCVN
Sbjct: 2498 SPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQ--------FLCVN 2549
Query: 2958 DRPPDRRCIPQSWVCDGDVDCTDGYDENQNCT--RRTCSENEFTCGY-GLCIPKIFRCDR 3014
+ C C G+ ++ C CG G+C
Sbjct: 2550 TLG--------GFTCK----CPPGFTQHHTACIDNNECGSQPSLCGAKGIC--------- 2588
Query: 3015 HNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPT 3074
N G +S E CQ G + T + ED D DG+ H C
Sbjct: 2589 QNTPGSFSCE--------------CQRGFSLDATGLNCEDVDECDGNHRCQHGCQN---I 2631
Query: 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFY 3134
+ C G + C+D NEC +P+ G +C +TL S+
Sbjct: 2632 LGGYRCGCPQGYIQHYQ-----WNQCVDE--------NECSNPNACG-SASCYNTLGSYK 2677
Query: 3135 CSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDG 3188
C+C G+ C D++EC+ C+ C N G Y+C C PGY R G
Sbjct: 2678 CACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG 2731
Score = 94.4 bits (233), Expect = 2e-18
Identities = 106/429 (24%), Positives = 154/429 (35%), Gaps = 92/429 (21%)
Query: 1063 LNNT---CSSSAFTCGHGECIP--AHWRC--------DKRNDCVDGSDEHNCPTHAPASC 1109
LN T C A C +G CIP + +RC D DC+D + C
Sbjct: 491 LNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDE-----------C 539
Query: 1110 LDTQYTCDNHQCISK--NWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFV 1167
T C N C++ ++ C ++ C + C + C N RC++
Sbjct: 540 --TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNT--- 594
Query: 1168 CDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRC--------DGVFDCSDNSDE 1219
DG C+ + T C D+C TN C DG F C +
Sbjct: 595 -DGSFQCICNAG-----FELTTDGKNCVDHDECT-TTNMCLNGMCINEDGSFKCIC---K 644
Query: 1220 AGCPTRPPGMCHSDEFQCQEDGICIPNF-------WECDGHPDCLYGSDEHNACVPKTCP 1272
G P G +D +CQ GIC+ + CD P G D CV
Sbjct: 645 PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGR-VCVDTHMR 703
Query: 1273 SS-YFHCDNGNCIH-------RAWLCDRDNDCGDMSDEKDCPTQPFR-----CPSWQW-- 1317
S+ Y G C+ ++ C + D G + CP + C S
Sbjct: 704 STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT 763
Query: 1318 -------QC-LGHNICVNLSVVCD---GIFDCPNGTDESPLCNGNSCSDFNGGCTHE--- 1363
+C L +IC N +C+ G + C + P +G +C D + +
Sbjct: 764 VDGRDINECALDPDICAN--GICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLC 821
Query: 1364 ----CVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGY 1419
C P C CP G++ +++TCEDI+EC+ + C N GSF C C G
Sbjct: 822 DNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGS 881
Query: 1420 MLESDGRTC 1428
L S G C
Sbjct: 882 KLSSTGLIC 890
Score = 91.3 bits (225), Expect = 2e-17
Identities = 151/658 (22%), Positives = 221/658 (33%), Gaps = 187/658 (28%)
Query: 3489 FTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKC---IPIWWKCDGQKDCSDGSDEL 3545
+TC CP ++ +Q++G CM M S + N C +P + + +
Sbjct: 1715 YTCICPPEY--MQVNGGHNCMDMRKSFCYRSYNGTTCENELPF-----------NVTKRM 1761
Query: 3546 ALCPQRFCRLGQFQCSDGNCTSP-----QTLCNAHQNCPDGSDEDRL--LCENHHCDSNE 3598
C + C C +P +T+C N P + + + C
Sbjct: 1762 CCCTYNVGKAWNKPCEP--CPTPGTADFKTICG---NIPGFTFDIHTGKAVDIDECKEIP 1816
Query: 3599 WQCANKRCIPE--SWQCD-----TFND----CED-----NSDEDSSHCASRTCRPGQFRC 3642
CAN CI + S++C+ ++ND CED N D A PG +RC
Sbjct: 1817 GICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRC 1876
Query: 3643 ANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGV 3702
+K + C D + EC+ ++C + + +Y+CI NG
Sbjct: 1877 E----CAAGFKLSPNGACVDRN-----ECLEIPNVCSHGLCVDLQGSYQCICH----NGF 1923
Query: 3703 DDCRDNSDEQGCEERTCHPVGDFRCKN----HHCIPL-RWQCDGQNDC------------ 3745
+D + +E HP G+ CKN ++C+ ++ NDC
Sbjct: 1924 KASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQ 1983
Query: 3746 ---------------------------GDNSDEEN--------CAPREC--TESEFRCVN 3768
G N + N C+P C E FRC+
Sbjct: 1984 VCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI- 2042
Query: 3769 QQCIPSRWI----CDHYNDCGDNSDERDCEMRTC--HPEYFQCTSGHCVHSELKCDGSAD 3822
C P + C N+C + D C +C P FQC C + D
Sbjct: 2043 --CPPGYEVKSENCIDINEC--DEDPNICLFGSCTNTPGGFQCL---CPPGFVLSDNGRR 2095
Query: 3823 CLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVP 3882
C D + ++ C T F +G F KC G+G + LC P
Sbjct: 2096 CFD-TRQSFCFTNFENGKCSVPKAFNTTKA-------KCCCSKMPGEGWGDPCELC---P 2144
Query: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIP 3942
+ F+ + C Y H + D + +E C E C NG CI
Sbjct: 2145 KDDEVAFQ---DLCPYGHGTVPSLHDTREDVNE------------CLESPGICSNGQCIN 2189
Query: 3943 HDNV-----------------CDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEG 3985
D C D D+C + C G TC I G
Sbjct: 2190 TDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP---CGNG---TCTNVI----------G 2233
Query: 3986 GFICSCTAGFETNVFDRTSCLDINECEQFG-TCPQHCRNTKGSYECVCADGFTSMSDR 4042
F C+C GFE +C DINEC Q C C NT GSYEC C G+ D+
Sbjct: 2234 SFECNCNEGFEPG--PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
Score = 89.7 bits (221), Expect = 6e-17
Identities = 108/410 (26%), Positives = 151/410 (36%), Gaps = 83/410 (20%)
Query: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI--PQ 2879
C+ C N CIP V + + G D N C+S+ C +G C+ P
Sbjct: 498 CKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--CTNGDCVNTPG 554
Query: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW----IC--------DG 2927
+YC F + +C + C+ + C GRC+ ++ IC DG
Sbjct: 555 SYYCKCHAG-FQRTPTKQACIDIDE-CIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDG 612
Query: 2928 DNDCGDMSDEDKRHQCQNQNC--SDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN 2985
N C D + + C N C D F C+ C P + CTD DE
Sbjct: 613 KN-CVDHDECTTTNMCLNGMCINEDGSFKCI--------CKPGFVLAPNGRYCTD-VDEC 662
Query: 2986 QN---CTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNG 3042
Q C C +E + FRCD D R C+ + TC G
Sbjct: 663 QTPGICMNGHCINSEGS----------FRCDCPPGLAVGMDGRVCVDTHMRS---TCYGG 709
Query: 3043 -----------RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMM 3091
++K+ C + D G G EP C P C E
Sbjct: 710 IKKGVCVRPFPGAVTKSECCCANPDYGFG-----------EP-CQP----CPAKNSAEFH 753
Query: 3092 KLCNH-LDDCLDNSDEKGCGINECH-DPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRT 3149
LC+ + +D D INEC DP I + C + S+ C+C GY+ + R
Sbjct: 754 GLCSSGVGITVDGRD-----INECALDPDICA-NGICENLRGSYRCNCNSGYEPDASGRN 807
Query: 3150 CVDIDECTEMPFVCSQK-CENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
C+DIDEC +C C N GSY C C PGY+ + +TC + E
Sbjct: 808 CIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE 857
Score = 88.6 bits (218), Expect = 1e-16
Identities = 149/656 (22%), Positives = 230/656 (35%), Gaps = 164/656 (25%)
Query: 3477 SHLCLIKPGGKGFTCECPDDFRT-LQLSGSTYCMPMCSSTQFLCANNEKCIPIW--WKCD 3533
S +C+ PG F CEC + + + + + + C LC C+ ++CD
Sbjct: 1128 SGICVNTPGS--FECECFEGYESGFMMMKNCMDIDECERNPLLCRGGT-CVNTEGSFQCD 1184
Query: 3534 ---------GQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSP----QTLCN-AHQNCP 3579
++DC D ++ C L C +G C + Q CN +Q P
Sbjct: 1185 CPLGHELSPSREDCVDINE---------CSLSDNLCRNGKCVNMIGTYQCSCNPGYQATP 1235
Query: 3580 DG---SDEDRLLCENHHCDSNEWQCANKR------------CIPESWQCDTFNDCEDNSD 3624
D +D D + N CD+ QC N +P+ C ++CE+N D
Sbjct: 1236 DRQGCTDIDECMIMNGGCDT---QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPD 1292
Query: 3625 E-DSSHCASRTCRPGQFRCA--NGRCIPQAWKCDVD-NDCGDHSDEPIEECMSSAHLCDN 3680
D C T PG++RC +G K +D N+C +S+ CM C+N
Sbjct: 1293 ICDGGQC---TNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNI----CMFGE--CEN 1343
Query: 3681 FTEFS----CKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHH----- 3731
T+ S C+ Y C VD+C + + G F+C
Sbjct: 1344 -TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGN 1402
Query: 3732 ---CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDN 3787
CI L +G + C N+ N T +RC ++ + C ++C +N
Sbjct: 1403 GIKCIDLDECSNGTHQCSINAQCVN------TPGSYRCACSEGFTGDGFTCSDVDECAEN 1456
Query: 3788 SDERDCEMRTCHPEYFQCTSGHCVH--SELKCDGSADCLDASDEADCPTRFPDGAYCQAT 3845
+ C +G C++ +C+ ASD C + ++
Sbjct: 1457 IN--------------LCENGQCLNVPGAYRCECEMGFTPASDSRSCQD-IDECSFQNIC 1501
Query: 3846 MFECKNH-------VCIPPY------WKCDGDDDCGDGSDEELHLCLDVP----CNSPNR 3888
+F N+ +C Y C D+C D + LC++ P CN P
Sbjct: 1502 VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPD 1561
Query: 3889 FR-------CDNNR---CIYSHEV-------CNGVDDCGDGTDETEEHCR--KPTPKPC- 3928
F+ C +NR C CN + G G + C K PC
Sbjct: 1562 FQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCN--TEIGVGVSRSSCCCSLGKAWGNPCE 1619
Query: 3929 -------TEYEYKCGNGHCI---PHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQN 3978
TEY C G P + +D D+C + +C+
Sbjct: 1620 TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQE---------------LPGLCQGG 1664
Query: 3979 CTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQF-GTC-PQHCRNTKGSYECVC 4032
G F C C G+ + D C DI+EC G C P C NT G+Y C+C
Sbjct: 1665 NCINTFGSFQCECPQGYYLSE-DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCIC 1719
Score = 88.6 bits (218), Expect = 1e-16
Identities = 133/586 (22%), Positives = 211/586 (36%), Gaps = 137/586 (23%)
Query: 2653 NPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCI----------VDNGERCG 2701
N C++ C C P G +C CP + L++N + C +NG+
Sbjct: 2058 NECDEDPNICLFGSCTNTPGGFQCLCPP--GFVLSDNGRRCFDTRQSFCFTNFENGKCSV 2115
Query: 2702 ASSFTCSNGRCI-----SEEWK-----CDNDND------CGDGSDEMESVCA----LHTC 2741
+F + +C E W C D++ C G + S+ ++ C
Sbjct: 2116 PKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNEC 2175
Query: 2742 SPTAFTCANGRCVQY--SYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFI 2799
+ C+NG+C+ S+RC+ G D G RC+
Sbjct: 2176 LESPGICSNGQCINTDGSFRCEC--PMGYNLDYTGV----------------RCVD---- 2213
Query: 2800 CNGVDNCHDNNTSDEKNCPDRTCQS--GYTKCHNSNICIPRVYL-CDGDNDCGDNSDENP 2856
D C N C + TC + G +C+ + P + C+ N+C +NP
Sbjct: 2214 ---TDECSIGNP-----CGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECA----QNP 2261
Query: 2857 TYCT---THTCSSSEFQCASGRCIPQHW-YCDQETDCFDASDEPASCGHSERTCLADEFK 2912
C +T S E C G + + C +C + + S G + L F
Sbjct: 2262 LLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN-LIGTFM 2320
Query: 2913 C---DGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQS 2969
C G P C +N+C K C+N C + I S
Sbjct: 2321 CICPPGMARRPDGEGCVDENEC-----RTKPGICENGRCVN---------------IIGS 2360
Query: 2970 WVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLY 3029
+ C+ C +G+ + + T C +N GLC ++ + C S R +
Sbjct: 2361 YRCE----CNEGFQSSSSGTE--CLDNR----QGLCFAEVLQ----TICQMASSSRNLV- 2405
Query: 3030 QTCQQNQFTCQNGRCIS-KTFVCDEDNDCGDGSDELMHLC-HTPEPT--------CPPHE 3079
+++ C GR + +C G+ + +C H P T C
Sbjct: 2406 ---TKSECCCDGGRGWGHQCELCPLP-----GTAQYKKICPHGPGYTTDGRDIDECKVMP 2457
Query: 3080 FKCDNGRCIEMM---KLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCS 3136
C NG+CI M + + D S ++EC S C++ C +T S+ CS
Sbjct: 2458 NLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQ-SPKPCNYICKNTEGSYQCS 2516
Query: 3137 CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGY 3182
C GY L D +TC D+DEC C C N +G + CKC PG+
Sbjct: 2517 CPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF 2562
Score = 88.2 bits (217), Expect = 2e-16
Identities = 124/546 (22%), Positives = 173/546 (31%), Gaps = 151/546 (27%)
Query: 998 CGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCV-----------------P 1040
C CP G L+ + C +C L C+NG+CV P
Sbjct: 1183 CDCPLGHELSPSREDCVD-------INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATP 1235
Query: 1041 NYYLCDGVDDC---HDNSDEQLC---GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVD 1094
+ C +D+C + D Q G+ +CS G C+ D D
Sbjct: 1236 DRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICD 1295
Query: 1095 GSDEHNCPTHAPASCLDT-QYTCDNHQCISKNWVCDTDNDCGDGSDEKN----------- 1142
G N P C D + D CI N N C G E
Sbjct: 1296 GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLG 1355
Query: 1143 ---------CNSTETCQPSQFNCPNHR-CIDL--SFVC--------DGDK-----DCVDG 1177
C + C+ NC H C+++ SF C +G K +C +G
Sbjct: 1356 YSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNG 1415
Query: 1178 SDEVGCVLNC--TASQFKCASGDKCIGVTNRCDGVFDCSDNSD--EAGCPTRPPGMCHSD 1233
+ + C T ++CA + G C V +C++N + E G PG +
Sbjct: 1416 THQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCE 1475
Query: 1234 EFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPS--SYFHCDNGNCIHRAWLCD 1291
C+ + C +C + N CV TC + FHC +CD
Sbjct: 1476 ---CEMGFTPASDSRSCQDIDECSF----QNICVFGTCNNLPGMFHC----------ICD 1518
Query: 1292 R----DNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL 1347
D G+ +D +C P C + +CVN G ++C D
Sbjct: 1519 DGYELDRTGGNCTDIDEC-ADPINCVN--------GLCVNTP----GRYECNCPPDFQLN 1565
Query: 1348 CNGNSCSDFNGG---------------CTHECVQEPFGAKCLCPLGFLLANDSKTC---- 1388
G C D G C E + C C LG N +TC
Sbjct: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
Query: 1389 -----------------------EDIDECDILGSCSQ--HCYNMRGSFRCSCDTGYMLES 1423
EDIDEC L Q +C N GSF+C C GY L
Sbjct: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
Query: 1424 DGRTCK 1429
D R C+
Sbjct: 1686 DTRICE 1691
Score = 86.3 bits (212), Expect = 7e-16
Identities = 112/477 (23%), Positives = 174/477 (36%), Gaps = 73/477 (15%)
Query: 982 GDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPN 1041
G+ C PV + + CP G N +T + +E C C+ G C+
Sbjct: 1615 GNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDE-----CQELPGLCQGGNCINT 1669
Query: 1042 Y--YLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPA--HWRCDKRNDCVDGSD 1097
+ + C+ + + D ++C ++ C + CG G C ++ C + + +
Sbjct: 1670 FGSFQCECPQGYYLSEDTRICEDIDE-CFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNG 1728
Query: 1098 EHNCPTHAPASCLDTQY--TCDNHQC--ISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQ 1153
HNC + C + TC+N ++K C T N K N + C+P
Sbjct: 1729 GHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNV------GKAWN--KPCEP-- 1778
Query: 1154 FNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRC-DGVFD 1212
CP D +C + G K D+C + C +GV
Sbjct: 1779 --CPTPGTADFKTICGN----IPG-------FTFDIHTGKAVDIDECKEIPGICANGVCI 1825
Query: 1213 CSDNSDEAGCPTRPPGMCHSDEFQ-CQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
S CPT G ++D C++ C C + DC+ + C
Sbjct: 1826 NQIGSFRCECPT---GFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRC----EC 1878
Query: 1272 PSSYFHCDNGNCIHRAWLCDRDNDCG-----DMSDEKDCPTQP-FRCPSWQWQCL----- 1320
+ + NG C+ R + N C D+ C F+ Q C+
Sbjct: 1879 AAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC 1938
Query: 1321 -----GHNICVNL----SVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE--CVQEPF 1369
G+ C N + +C F+ + D + + CS F G C E
Sbjct: 1939 ERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDI---DECSSFFGQVCRNGRCFNEIG 1995
Query: 1370 GAKCLCPLGFLLANDSKTCEDIDECDIL-GSCSQ-HCYNMRGSFRCSCDTGYMLESD 1424
KCLC G+ L D K C D +EC L GSCS C N+ GSFRC C GY ++S+
Sbjct: 1996 SFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE 2052
Score = 85.9 bits (211), Expect = 9e-16
Identities = 110/427 (25%), Positives = 153/427 (35%), Gaps = 91/427 (21%)
Query: 27 ECDSAHFRCGSGHCI--PADWRCDG----------TKDCSDDADEIGCAVVTCQQGYFKC 74
EC + CGSG C+ P + C+ K+C D + C++ C
Sbjct: 1118 ECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMD--------IDECERNPLLC 1169
Query: 75 QSEGQCI--PNSWVCDQDQDCDDG---SDERQDCSQ-STCSSHQITCSNGQCIP--SEYR 126
+ G C+ S+ CD C G S R+DC + CS C NG+C+ Y+
Sbjct: 1170 RG-GTCVNTEGSFQCD----CPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQ 1224
Query: 127 CDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSS------DEINCT 180
C D C ++ NG C + +C S D +C
Sbjct: 1225 CSCNPGYQATPDRQGCT--DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1282
Query: 181 EI--CLHNEFSCGNGEC--IPRAYVCDHDNDCQDGSDEHAC-NYPTCGGYQFTCPSGRC- 234
+I C +N C G+C IP Y C + D C + C C G C
Sbjct: 1283 DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECE 1342
Query: 235 -IYQNWVCD---------GEDDCKDNGDEDGCESGPH--DVH----------KCSPREWS 272
+++C G C D D CE G H D+H KCS RE
Sbjct: 1343 NTKGSFICHCQLGYSVKKGTTGCTD---VDECEIGAHNCDMHASCLNIPGSFKCSCREGW 1399
Query: 273 CPESGRCISIYKVCDGILDC---------PGRE----DENNTSTGKYCSMTLCSALNCQY 319
+CI + + +G C PG E T G CS A N
Sbjct: 1400 IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINL 1459
Query: 320 ----QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICD-QKCESRPGRHLCHCE 374
QC P C C G+ +DSR+C + D+C IC C + PG C C+
Sbjct: 1460 CENGQCLNVPGAYRCECEMGFT-PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICD 1518
Query: 375 EGYILER 381
+GY L+R
Sbjct: 1519 DGYELDR 1525
Score = 85.5 bits (210), Expect = 1e-15
Identities = 141/587 (24%), Positives = 206/587 (35%), Gaps = 145/587 (24%)
Query: 3536 KDCSDGSDELALCPQRFCR--LGQFQCSDGNCTSPQTLCNAHQNCPDGSD--EDRLLCEN 3591
+D ++ + + +C C G ++C NC S + +NC D + +RLLC+N
Sbjct: 767 RDINECALDPDICANGICENLRGSYRC---NCNSGYEPDASGRNCIDIDECLVNRLLCDN 823
Query: 3592 HHCDSN--EWQCANKRCIP------ESWQCDTFNDCEDNSDEDSSHCASRTCRP--GQFR 3641
C + + C C P E+ C+ N+CE N C + CR G F
Sbjct: 824 GLCRNTPGSYSCT---CPPGYVFRTETETCEDINECESNP------CVNGACRNNLGSFN 874
Query: 3642 CANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNG 3701
C C P + C I+ + L N + C+ N + C
Sbjct: 875 C---ECSPGSKLSSTGLIC-------IDSLKGTCWL--NIQDSRCEVNINGATLKSECCA 922
Query: 3702 VDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTE 3761
S + CE T P G R K C+ N+C P C
Sbjct: 923 TLGAAWGSPCERCELDTACPRGLARIKGV-------TCEDVNEC-------EVFPGVCPN 968
Query: 3762 SEFRCVNQQCIPSRWICDHYNDCGDNSDERDC---EMRTCHPEYFQCTSGHCVHSELKCD 3818
RCVN + + C+ + R C M C+ ++ + H V + + D
Sbjct: 969 G--RCVNSK---GSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMD 1023
Query: 3819 GSADCLDASDEADCP-----------TRFPDGAYCQ------------ATMFECKNHVCI 3855
+ A+ +C T P GA + ECK +
Sbjct: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGM 1083
Query: 3856 PPYWKCD---GDDDC----GDGSDEELHLCLDVP--------------CNSPNRFRCDNN 3894
Y KC G C G D E C D+ N+P F C+
Sbjct: 1084 CTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECE-- 1141
Query: 3895 RCIYSHEV-------CNGVDDCGDGTDETEEHCRKPTPKPCTE----YEYKCGNGHCI-P 3942
C +E C +D+C + CR T C ++ C GH + P
Sbjct: 1142 -CFEGYESGFMMMKNCMDIDEC----ERNPLLCRGGT---CVNTEGSFQCDCPLGHELSP 1193
Query: 3943 HDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDR 4002
C D ++C SD L C GK C I G + CSC G++ DR
Sbjct: 1194 SREDCVDINECS-LSDNL-CRNGK---CVNMI----------GTYQCSCNPGYQATP-DR 1237
Query: 4003 TSCLDINECEQF-GTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCA 4048
C DI+EC G C C N++GSYEC C++G+ M D G+ CA
Sbjct: 1238 QGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPD--GRSCA 1282
Score = 84.3 bits (207), Expect = 3e-15
Identities = 62/214 (28%), Positives = 87/214 (40%), Gaps = 34/214 (15%)
Query: 1240 DGICIPNFWECDGHPDCLYGSDEHNACVP-KTCPSSYFHCDNGNCIHR--AWLCDRDNDC 1296
+G CIP + Y D + C+ C S+ C NG+C++ ++ C
Sbjct: 507 NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN--PCTNGDCVNTPGSYYCK----- 559
Query: 1297 GDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVC--------DGIFDCPNGTDESPLC 1348
C R P+ Q C+ + C+ V+C DG F C
Sbjct: 560 --------CHAGFQRTPTKQ-ACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
Query: 1349 NGNSCSDFNGGCTHE------CVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQ 1402
+G +C D + T C+ E KC+C GF+LA + + C D+DEC G C
Sbjct: 611 DGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMN 670
Query: 1403 -HCYNMRGSFRCSCDTGYMLESDGRTCKVTASES 1435
HC N GSFRC C G + DGR C T S
Sbjct: 671 GHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
Score = 84.3 bits (207), Expect = 3e-15
Identities = 161/691 (23%), Positives = 245/691 (35%), Gaps = 164/691 (23%)
Query: 3467 NPCGTNNGGCSH-LCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCAN---- 3521
N C CSH LC+ G + C C + F+ Q T CM + + C N
Sbjct: 1894 NECLEIPNVCSHGLCVDLQGS--YQCICHNGFKASQ--DQTMCMDVDECERHPCGNGTCK 1949
Query: 3522 ------NEKCIPIWWKCDGQKDCSDGSDELALCPQRFCR-------LGQFQCSDGNCTSP 3568
N C P ++ DC D DE + + CR +G F+C C
Sbjct: 1950 NTVGSYNCLCYP-GFELTHNNDCLD-IDECSSFFGQVCRNGRCFNEIGSFKCL---CNEG 2004
Query: 3569 QTLCNAHQNCPDGSDEDRL--LCENHHCDSNEWQCANKRCI------PESWQCDTFNDCE 3620
L +NC D ++ L C C + E + RCI +S C N+C
Sbjct: 2005 YELTPDGKNCIDTNECVALPGSCSPGTCQNLE---GSFRCICPPGYEVKSENCIDINEC- 2060
Query: 3621 DNSDEDSSHCASRTCR--PGQFRCA---------------------------NGRC-IPQ 3650
DED + C +C PG F+C NG+C +P+
Sbjct: 2061 ---DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPK 2117
Query: 3651 AW-----KCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDC 3705
A+ KC G+ +P E C + F + C + +P ++ + +D
Sbjct: 2118 AFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVA--FQDL-CPYGHGTVP--SLHDTREDV 2172
Query: 3706 RDNSDEQG-CEERTC-HPVGDFRCKNHHCIPLRWQCDGQN----DCGDNSDEENCAPREC 3759
+ + G C C + G FRC+ P+ + D D + S C C
Sbjct: 2173 NECLESPGICSNGQCINTDGSFRCE----CPMGYNLDYTGVRCVDTDECSIGNPCGNGTC 2228
Query: 3760 TE--SEFRC-VNQQCIPSRWI-CDHYNDCGDNSDERDCEMRTCHP-EYFQCTS--GHCVH 3812
T F C N+ P + C+ N+C N C R + ++CT G+ +
Sbjct: 2229 TNVIGSFECNCNEGFEPGPMMNCEDINECAQNP--LLCAFRCMNTFGSYECTCPIGYALR 2286
Query: 3813 SELK-CDGSADCLDASDEAD----------------CP---TRFPDGA------YCQATM 3846
+ K C +C + + + CP R PDG C+
Sbjct: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
Query: 3847 FECKNHVCIPPY--WKCDGDDDCGDGS------DEELHLCLDVPCNSPNRFRCDNNRCIY 3898
C+N C+ ++C+ ++ S D LC + + + +
Sbjct: 2347 GICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVT 2406
Query: 3899 SHEVCNGVDDCGDGTDETEEHCRKPTPKPCT-EYEYKCGNGHCIPHDNVCDDADDCGDWS 3957
E C D G G E C P P T +Y+ C +G D D D+C
Sbjct: 2407 KSECCC---DGGRGWGHQCELC----PLPGTAQYKKICPHGPGYTTDG--RDIDEC---- 2453
Query: 3958 DELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGT- 4016
N+C G F C C G+ T++ TSC+D++EC Q
Sbjct: 2454 -----------KVMPNLCTNGQCINTMGSFRCFCKVGYTTDI-SGTSCIDLDECSQSPKP 2501
Query: 4017 CPQHCRNTKGSYECVCADGFTSMSDRPGKRC 4047
C C+NT+GSY+C C G+ D GK C
Sbjct: 2502 CNYICKNTEGSYQCSCPRGYVLQED--GKTC 2530
Score = 83.6 bits (205), Expect = 4e-15
Identities = 113/457 (24%), Positives = 155/457 (33%), Gaps = 130/457 (28%)
Query: 3635 CRPGQFRCANGRCIP----------QAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEF 3684
C+ C NGRCIP +K D + DC D ++EC S+ C N
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCID-----VDECTSNP--CTNGDCV 550
Query: 3685 SCKTNYRC--------IPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLR 3736
+ +Y C P C +D+C N CKN C+
Sbjct: 551 NTPGSYYCKCHAGFQRTPTKQACIDIDECIQNG---------------VLCKNGRCV--- 592
Query: 3737 WQCDGQNDCGDN------SDEENCAPR-ECTESEFRCVNQQCIPS----RWICDHYNDCG 3785
DG C N +D +NC ECT + C+N CI + IC
Sbjct: 593 -NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNM-CLNGMCINEDGSFKCICKPGFVLA 650
Query: 3786 DN----SDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP---D 3838
N +D +C+ C +GHC++SE GS C DCP D
Sbjct: 651 PNGRYCTDVDECQTPGI------CMNGHCINSE----GSFRC-------DCPPGLAVGMD 693
Query: 3839 GAYCQATMFE------CKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD 3892
G C T K VC+ P+ +C + + PC C
Sbjct: 694 GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPD---YGFGEPCQP-----CP 745
Query: 3893 NNRCIYSHEVC-NGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDAD 3951
H +C +GV DG D E C C NG C +N+
Sbjct: 746 AKNSAEFHGLCSSGVGITVDGRDINE----------CALDPDICANGIC---ENL----- 787
Query: 3952 DCGDWSDELGCNKGKE-----RTCAE--------NICEQNCTQLNEGGFICSCTAGFETN 3998
S CN G E R C + +C+ + G + C+C G+
Sbjct: 788 ---RGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFR 844
Query: 3999 VFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADG 4035
+ +C DINECE CRN GS+ C C+ G
Sbjct: 845 T-ETETCEDINECESNPCVNGACRNNLGSFNCECSPG 880
Score = 83.6 bits (205), Expect = 4e-15
Identities = 134/604 (22%), Positives = 219/604 (36%), Gaps = 143/604 (23%)
Query: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
F C+ E I KC +CS+G+ + ++ Q G ++C+
Sbjct: 1391 FKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA--------------- 1435
Query: 3577 NCPDGSDEDRLLCEN-HHCDSNEWQCANKRC--IPESWQCDT---FNDCEDN-SDEDSSH 3629
C +G D C + C N C N +C +P +++C+ F D+ S +D
Sbjct: 1436 -CSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE 1494
Query: 3630 CASR------TCR--PGQFRCANGRCIPQAWKCD----VDNDCGDHSDEPIEECMSSAH- 3676
C+ + TC PG F C CD +D G+ +D I+EC +
Sbjct: 1495 CSFQNICVFGTCNNLPGMFHCI----------CDDGYELDRTGGNCTD--IDECADPINC 1542
Query: 3677 ---LCDNFT---EFSCKTNYRCIPKWAVC--NGVDDCRDNSDEQGCEERTCH-PVGDFRC 3727
LC N E +C +++ P C N V +C +G +C+ +G
Sbjct: 1543 VNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVS 1602
Query: 3728 KNHHCIPL--RWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCI---PSRWICDHYN 3782
++ C L W N C E C P TE C + P I + +
Sbjct: 1603 RSSCCCSLGKAW----GNPC------ETCPPVNSTEYYTLCPGGEGFRPNPITIILEDID 1652
Query: 3783 DCGDNSDERDCEMRTCHPEY----FQCTSGHCVHSELK-CDGSADCLDASDEADCPTRFP 3837
+C + C+ C + +C G+ + + + C+ +C A P
Sbjct: 1653 ECQELPGL--CQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECF-----AHPGVCGP 1705
Query: 3838 DGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLD-VPCNSPNRFRCDNNRC 3896
Y + C +C P Y + +G +C D + + C + F C
Sbjct: 1706 GTCYNTLGNYTC---ICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMC 1762
Query: 3897 IYSHEV-------CN-----GVDD----CGDGTDET-EEHCRKPTP-KPCTEYEYKCGNG 3938
++ V C G D CG+ T + H K C E C NG
Sbjct: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANG 1822
Query: 3939 HCIPHDN-----------------VCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQ 3981
CI VC+D D+C + +N+C++N
Sbjct: 1823 VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSN---------------GDNLCQRNADC 1867
Query: 3982 LNE-GGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH--CRNTKGSYECVCADGFTS 4038
+N G + C C AGF+ + +C+D NEC + H C + +GSY+C+C +GF +
Sbjct: 1868 INSPGSYRCECAAGFKLS--PNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKA 1925
Query: 4039 MSDR 4042
D+
Sbjct: 1926 SQDQ 1929
Score = 83.6 bits (205), Expect = 4e-15
Identities = 119/487 (24%), Positives = 166/487 (34%), Gaps = 102/487 (20%)
Query: 987 FCFPVPNFQR-VCGCPYGMRLASNHLTCE-------GDPTNEPPTEQCGLFSFPCKNGRC 1038
FCF NF+ C P C GDP P + F C G
Sbjct: 2103 FCFT--NFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160
Query: 1039 VPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
V HD ++ N C S C +G+CI DGS
Sbjct: 2161 T--------VPSLHDTREDV------NECLESPGICSNGQCINT-----------DGSFR 2195
Query: 1099 HNCPT-----HAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEK-----NCNSTET 1148
CP + C+DT C N CG+G+ CN E
Sbjct: 2196 CECPMGYNLDYTGVRCVDTDE-------------CSIGNPCGNGTCTNVIGSFECNCNEG 2242
Query: 1149 CQPS-QFNCPN-HRCIDLSFVCDGDKDCVDGSDEVGCVLNCTA--SQFKCASGDKCIGVT 1204
+P NC + + C +C GS E C + Q C D+C
Sbjct: 2243 FEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL 2302
Query: 1205 NRCD----------GVFDCSDNSDEAGCPTRPPGMCHSDEFQCQ-EDGICIPNFWECDGH 1253
+ C+ G F C G RP G DE +C+ + GIC +G
Sbjct: 2303 HDCESRGMMCKNLIGTFMCIC---PPGMARRPDGEGCVDENECRTKPGICE------NGR 2353
Query: 1254 PDCLYGSDEHNACVPKTCPSSYFHC-DN--GNCIHRAW--LCDRDNDCGDMSDEKDCPTQ 1308
+ GS SS C DN G C +C + ++ + +C
Sbjct: 2354 CVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCD 2413
Query: 1309 PFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNG----TDESPLCNGNSCSDFNGGCTH-E 1363
R W QC +C L CP+G TD + + C CT+ +
Sbjct: 2414 GGR--GWGHQC---ELCP-LPGTAQYKKICPHGPGYTTDGRDI---DECKVMPNLCTNGQ 2464
Query: 1364 CVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGS-CSQHCYNMRGSFRCSCDTGYMLE 1422
C+ +C C +G+ +C D+DEC C+ C N GS++CSC GY+L+
Sbjct: 2465 CINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQ 2524
Query: 1423 SDGRTCK 1429
DG+TCK
Sbjct: 2525 EDGKTCK 2531
Score = 81.3 bits (199), Expect = 2e-14
Identities = 153/702 (21%), Positives = 238/702 (33%), Gaps = 191/702 (27%)
Query: 2648 KQQCNN--PCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSF 2705
+Q C + C NGGC C EC C EG + + R +D C +
Sbjct: 1237 RQGCTDIDECMIMNGGCDTQCTNSEGSYECSCS-EGYALMPDGRSCADIDE---CENNPD 1292
Query: 2706 TCSNGRC--ISEEWKCDNDNDCGDG---SDEMESVCALHTCSPTAFTCANGRC------- 2753
C G+C I E++C C DG S +M++ ++ C + C G C
Sbjct: 1293 ICDGGQCTNIPGEYRCL----CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSF 1348
Query: 2754 -----VQYS------------------YRCDYYNDCGD--GSDEAGCL------------ 2776
+ YS + CD + C + GS + C
Sbjct: 1349 ICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCID 1408
Query: 2777 FRDCNATTEFMCNNRRCIPRE---------------FICNGVDNCHDN-NTSDEKNCPDR 2820
+C+ T N +C+ F C+ VD C +N N + C +
Sbjct: 1409 LDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNV 1468
Query: 2821 T------CQSGYT------------KCHNSNICI-------PRVYLCDGDNDCGDNSDEN 2855
C+ G+T +C NIC+ P ++ C D+ G D
Sbjct: 1469 PGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD--GYELDRT 1526
Query: 2856 PTYCTTHTCSSSEFQCASGRCI--PQHWYCDQETD---------CFD------------A 2892
CT + C +G C+ P + C+ D C D
Sbjct: 1527 GGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPR 1586
Query: 2893 SDEPASC------GHSERTCLADEFKCDGGRCIP------SEW--ICDGDNDCGD----- 2933
D SC G S +C K G C +E+ +C G
Sbjct: 1587 GDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITI 1646
Query: 2934 -MSDEDKRHQ----CQNQNCSDS--EFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE-- 2984
+ D D+ + CQ NC ++ F C C PQ + D + DE
Sbjct: 1647 ILEDIDECQELPGLCQGGNCINTFGSFQC--------EC-PQGYYLSEDTRICEDIDECF 1697
Query: 2985 --NQNCTRRTCSEN--EFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQ 3040
C TC +TC +C P+ + + ++C D + Y++ N TC+
Sbjct: 1698 AHPGVCGPGTCYNTLGNYTC---ICPPEYMQVNGGHNCMDM--RKSFCYRS--YNGTTCE 1750
Query: 3041 NGRCISKTF-VCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDD 3099
N + T +C + G ++ C TP +FK +C ++
Sbjct: 1751 NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTA----DFKT----------ICGNIPG 1796
Query: 3100 -CLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE 3158
D K I+EC + + C + + SF C C G+ C DIDEC+
Sbjct: 1797 FTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSN 1856
Query: 3159 MPFVCSQK--CENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
+C + C N GSY C+CA G+ P+G +N +E
Sbjct: 1857 GDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLE 1898
Score = 80.5 bits (197), Expect = 4e-14
Identities = 106/462 (22%), Positives = 155/462 (33%), Gaps = 76/462 (16%)
Query: 998 CGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
C CP G L + C+ C CKN + ++C D
Sbjct: 2277 CTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN---LIGTFMCICPPGMARRPDG 2333
Query: 1058 QLCGTLNNTCSSSAFTCGHGECIP--AHWRCDKRNDCVDGSDEHNCPTHAPASCL-DTQY 1114
+ C N C + C +G C+ +RC+ S C + C +
Sbjct: 2334 EGCVD-ENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQ 2392
Query: 1115 TCDNHQCISKNWV----CDTDNDCGDGSDEKNCNSTETCQPSQFNCPN-----------H 1159
T S+N V C D G G + C T Q + CP+
Sbjct: 2393 TICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI-CPHGPGYTTDGRDID 2451
Query: 1160 RCIDLSFVCDGDKDCVD--GSDEVGCVLNCTA--SQFKCASGDKCIGVTNRCDGVFDCSD 1215
C + +C + C++ GS C + T S C D+C C+ + ++
Sbjct: 2452 ECKVMPNLCTNGQ-CINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTE 2510
Query: 1216 NSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNA---CVPKTCP 1272
S + CP + QEDG + EC + +HN CV T
Sbjct: 2511 GSYQCSCPRG---------YVLQEDGKTCKDLDECQ--------TKQHNCQFLCV-NTLG 2552
Query: 1273 SSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVC 1332
C G H C +N+CG +QP C + IC N
Sbjct: 2553 GFTCKCPPGFTQHHT-ACIDNNECG---------SQPSLCGA-------KGICQNTP--- 2592
Query: 1333 DGIFDCPNGTDESPLCNGNSCSDF-----NGGCTHECVQEPFGAKCLCPLGFLLANDSKT 1387
G F C S G +C D N C H C G +C CP G++
Sbjct: 2593 -GSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQ 2651
Query: 1388 CEDIDECDILGSC-SQHCYNMRGSFRCSCDTGYMLESDGRTC 1428
C D +EC +C S CYN GS++C+C +G+ + C
Sbjct: 2652 CVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSAC 2693
Score = 79.7 bits (195), Expect = 6e-14
Identities = 124/544 (22%), Positives = 189/544 (34%), Gaps = 98/544 (18%)
Query: 2700 CGASSFTCSNGRCIS--EEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY- 2756
C + C NGRCI ++C+ C G + + + T+ C NG CV
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCE----CNMGYKQDANGDCIDVDECTSNPCTNGDCVNTP 553
Query: 2757 -SYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK 2815
SY C + + C+ D +C N RC+ + + N T+D K
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
Query: 2816 NCPDRTCQSGYTKCHNSNICIPRVYLC-DGDNDC----GDNSDENPTYCTTHTCSSSEFQ 2870
NC D + +C +N+C+ + + DG C G N YCT +
Sbjct: 614 NCVD------HDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGI 667
Query: 2871 CASGRCIPQH--WYCDQETDCFDASDEPASCG-HSERTCLADEFKCDGGRCI-PSEWICD 2926
C +G CI + CD D H TC K G C+ P
Sbjct: 668 CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKK---GVCVRPFPGAVT 724
Query: 2927 GDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCT-DGYDEN 2985
C D CQ C P + +C V T DG D N
Sbjct: 725 KSECCCANPDYGFGEPCQP---------C-----PAKNSAEFHGLCSSGVGITVDGRDIN 770
Query: 2986 QNCTRRTCSENEFTCGYGLC--IPKIFRCDRHNDCGDYSDERGCL-YQTCQQNQFTCQNG 3042
+ C+ + C G+C + +RC+ ++ + R C+ C N+ C NG
Sbjct: 771 E------CALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG 824
Query: 3043 RCIS-----------------KTFVCDEDNDCGDGSDELMHLCHTPEPT----CPPHEFK 3081
C + +T C++ N+C + + + C + C P
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESNPCVNGACRNNLGSFNCECSPGSKL 883
Query: 3082 CDNGR-CIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCD--HNCTDTLTSFYCS-- 3136
G CI+ +K C N + C +N I+G C TL + + S
Sbjct: 884 SSTGLICIDSLK-----GTCWLNIQDSRCEVN------INGATLKSECCATLGAAWGSPC 932
Query: 3137 --------CRPGYKLMSDKRTCVDIDECTEMPFVCSQ-KCENVIGSYICKCAPGYLREPD 3187
C G + TC D++EC P VC +C N GS+ C+C G +
Sbjct: 933 ERCELDTACPRGLARIKGV-TCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGT 991
Query: 3188 GKTC 3191
G+ C
Sbjct: 992 GRVC 995
Score = 78.2 bits (191), Expect = 2e-13
Identities = 157/655 (23%), Positives = 222/655 (33%), Gaps = 138/655 (21%)
Query: 3480 CLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKC-IPIWW-----KCD 3533
C PGG F C CP F + C S F N KC +P + KC
Sbjct: 2072 CTNTPGG--FQCLCPPGF--VLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCC 2127
Query: 3534 GQKDCSDG-SDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSD--EDRLLCE 3590
K +G D LCP+ Q C G+ T P + H D ++ E +C
Sbjct: 2128 CSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP----SLHDTREDVNECLESPGICS 2183
Query: 3591 NHHCDSNEWQCANKRC-IPESWQCD-TFNDCEDNSDEDS--SHCASRTCRP--GQFRCAN 3644
N C + + + RC P + D T C D +DE S + C + TC G F C
Sbjct: 2184 NGQCINTD---GSFRCECPMGYNLDYTGVRCVD-TDECSIGNPCGNGTCTNVIGSFEC-- 2237
Query: 3645 GRCIPQAWKCDVDNDCGDHSD-EPIEECMSSAHLCD-------NFTEFSCKTNYRCIPKW 3696
C+ + G + E I EC + LC E +C Y
Sbjct: 2238 --------NCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
Query: 3697 AVCNGVDDCRDNSDEQGCEERTC---HPVGDFRCKNHHCIP-LRWQCDGQNDCGDNSDEE 3752
+C +D+C + + CE R + +G F C C P + + DG+ DE
Sbjct: 2290 KMCKDLDECAEGLHD--CESRGMMCKNLIGTFMCI---CPPGMARRPDGEGCV----DEN 2340
Query: 3753 NCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC---EMRTCHPEYFQC---- 3805
C + RCVN I + C+ +S +C C E Q
Sbjct: 2341 ECRTKPGICENGRCVN---IIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQM 2397
Query: 3806 ---TSGHCVHSELKCDGSA----DCL------DASDEADCP------TRFPDGAYCQATM 3846
+ SE CDG C A + CP T D C+
Sbjct: 2398 ASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMP 2457
Query: 3847 FECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDV--------PCN-----SPNRFRCDN 3893
C N CI G +D C+D+ PCN + ++C
Sbjct: 2458 NLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSC 2517
Query: 3894 NRCIYSHE---VCNGVDDCGDGTDETEEH-CRKPTPKPCTEYEYKCGNGHCIPHDNVCDD 3949
R E C +D+C +T++H C+ + KC G H C D
Sbjct: 2518 PRGYVLQEDGKTCKDLDEC-----QTKQHNCQFLCVNTLGGFTCKCPPGFT-QHHTACID 2571
Query: 3950 ADDCGDWSDELGCNKGKERTCAENICE-----------QNCTQLNE-------------- 3984
++CG G + T CE NC ++E
Sbjct: 2572 NNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNI 2631
Query: 3985 -GGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQ-HCRNTKGSYECVCADGFT 4037
GG+ C C G+ + + C+D NEC C C NT GSY+C C GF+
Sbjct: 2632 LGGYRCGCPQGYIQH-YQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFS 2685
Score = 77.0 bits (188), Expect = 4e-13
Identities = 102/440 (23%), Positives = 167/440 (37%), Gaps = 84/440 (19%)
Query: 9 ACTLLLALVACLAPASGQECDSAHFRCGSGHCIPA--DWRCDGTKDCSDDADEIGCAVVT 66
AC LA + + EC+ C +G C+ + + C+ + + D C +
Sbjct: 940 ACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIR 999
Query: 67 CQQGYFKCQSEGQCI---PNSWVCDQDQDCDDGS---DERQDCSQSTCSSHQITCSNGQC 120
+Q Y K E +CI P + D C G+ E ++C + ++ C G
Sbjct: 1000 MEQCYLKWD-EDECIHPVPGKFRMDACC-CAVGAAWGTECEECPKPGTKEYETLCPRGAG 1057
Query: 121 IPSEYRCDHVRDCPDGADENDCQ-YPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEI 177
+ R D + P D N+C+ +P C G C NT S KC +E
Sbjct: 1058 FAN--RGDVLTGRPFYKDINECKAFPGM----CTYGKCRNTIGSFKCRCNSGFALDMEER 1111
Query: 178 NCTEI--CLHNEFSCGNGECI--PRAYVCDHDNDCQDG--------------SDEHACNY 219
NCT+I C + CG+G C+ P ++ C+ + G + C
Sbjct: 1112 NCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG 1171
Query: 220 PTC----GGYQFTCPSGR--------CIYQNWVCDGEDDCKDNGD--------EDGCESG 259
TC G +Q CP G C+ N C D+ NG + C G
Sbjct: 1172 GTCVNTEGSFQCDCPLGHELSPSREDCVDIN-ECSLSDNLCRNGKCVNMIGTYQCSCNPG 1230
Query: 260 PHDVHKCSPREWSCPESGRCISIYKVCD-------GILDCPGREDENNTSTGKYCS---- 308
++ +P C + C+ + CD G +C E G+ C+
Sbjct: 1231 ----YQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDE 1286
Query: 309 ----MTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQI-WGICD-QKC 362
+C QC P C C G++ + D +TC++ ++C + IC +C
Sbjct: 1287 CENNPDICDG----GQCTNIPGEYRCLCYDGFMASM-DMKTCIDVNECDLNSNICMFGEC 1341
Query: 363 ESRPGRHLCHCEEGYILERG 382
E+ G +CHC+ GY +++G
Sbjct: 1342 ENTKGSFICHCQLGYSVKKG 1361
Score = 76.3 bits (186), Expect = 7e-13
Identities = 146/666 (21%), Positives = 220/666 (33%), Gaps = 176/666 (26%)
Query: 2648 KQQCNNPCEQFNGGCSHICAPG-----PNGAECQCPHEGNWYLANNRKHCIVDNGERCGA 2702
KQ N C + S+ C G P C+C H G + K +D E C
Sbjct: 526 KQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKC-HAG--FQRTPTKQACIDIDE-CIQ 581
Query: 2703 SSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY--SYRC 2760
+ C NGRC++ + + G C H T C NG C+ S++C
Sbjct: 582 NGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC 641
Query: 2761 ------------DYYNDCGDGSDEAGCLFRDC-NATTEFMCNNRRCIPREFICNGVDN-- 2805
Y D + C+ C N+ F C+ C P + G+D
Sbjct: 642 ICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCD---CPPG--LAVGMDGRV 696
Query: 2806 CHDNNTSDEKNCPDRTCQSGYTKCHNSNIC-------IPRVYLCDGDNDCG--------- 2849
C D + TC G K +C + + C + D G
Sbjct: 697 CVDTHMRS-------TCYGGIKK----GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCP 745
Query: 2850 -DNSDENPTYCTT-----------HTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPA 2897
NS E C++ + C+ CA+G C ++ +C ++ EP
Sbjct: 746 AKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGIC--ENLRGSYRCNC-NSGYEPD 802
Query: 2898 SCGHS---ERTCLADEFKCDGGRC--IPSEWIC---------DGDNDCGDMSDEDKRHQC 2943
+ G + CL + CD G C P + C C D+ +E + + C
Sbjct: 803 ASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI-NECESNPC 861
Query: 2944 QNQNC-----------------SDSEFLCVNDRPPDRRCIPQSWVCDGDVD--------- 2977
N C S + +C++ Q C+ +++
Sbjct: 862 VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECC 921
Query: 2978 CTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQF 3037
T G C R E + C GL K C+ N+C +
Sbjct: 922 ATLGAAWGSPCER---CELDTACPRGLARIKGVTCEDVNECEVFPG-------------- 964
Query: 3038 TCQNGRCISK--TFVCDEDNDCGDG----------SDELMHLCHT--PEPTC---PPHEF 3080
C NGRC++ +F C +C +G D M C+ E C P +F
Sbjct: 965 VCPNGRCVNSKGSFHC----ECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF 1020
Query: 3081 KCDNGRCIEMMKLCNHLDDC-------LDNSDEKGCG----------------INECHDP 3117
+ D C ++C + +G G INEC
Sbjct: 1021 RMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF 1080
Query: 3118 SISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVC-SQKCENVIGSYIC 3176
C +T+ SF C C G+ L ++R C DIDEC P +C S C N GS+ C
Sbjct: 1081 PGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFEC 1140
Query: 3177 KCAPGY 3182
+C GY
Sbjct: 1141 ECFEGY 1146
Score = 75.1 bits (183), Expect = 2e-12
Identities = 138/535 (25%), Positives = 191/535 (35%), Gaps = 96/535 (17%)
Query: 967 IQTGSNACNQPT-----HPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEP 1021
I TG NQ H N + C P + R C C G + +N GD +
Sbjct: 484 IITGLTILNQTIDICKHHANLCLNGRCIPTVSSYR-CECNMGYKQDAN-----GDCID-- 535
Query: 1022 PTEQCGLFSFPCKNGRCV--PNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
++C S PC NG CV P Y C +Q C ++ C + C +G C
Sbjct: 536 -VDECT--SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDE-CIQNGVLCKNGRC 591
Query: 1080 I--PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKN--WVCDTDNDCG 1135
+ ++C +D NC H + T C N CI+++ + C
Sbjct: 592 VNTDGSFQCICNAGFELTTDGKNCVDHDECT---TTNMCLNGMCINEDGSFKCICKPGFV 648
Query: 1136 DGSDEKNCNSTETCQPSQFNCPNHRCIDL--SFVCDGDKDCVDGSDEVGCVLNCTASQFK 1193
+ + C + CQ C N CI+ SF CD G D CV T +
Sbjct: 649 LAPNGRYCTDVDECQTPGI-CMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--DTHMRST 705
Query: 1194 CASGDK---CI----GVTNRCDGVFDCSDNSDEA-GCPTRPPGMCHSDEFQ--CQED-GI 1242
C G K C+ G + + C N D G P +P +S EF C GI
Sbjct: 706 CYGGIKKGVCVRPFPGAVTKSEC---CCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGI 762
Query: 1243 CIP--NFWECDGHPD-CLYGSDEH-NACVPKTCPSSYF------HC-DNGNCIHRAWLCD 1291
+ + EC PD C G E+ C S Y +C D C+ LCD
Sbjct: 763 TVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCD 822
Query: 1292 RDNDCGDMSDEKDCPTQP---FRCPSWQWQCLGH---NICVNLSVVCD-GIFDCPNGTDE 1344
+ C + C P FR + + + N CVN + + G F+C
Sbjct: 823 -NGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGS 881
Query: 1345 SPLCNGNSCSD-FNGGC------------------THEC---VQEPFGAKC-------LC 1375
G C D G C EC + +G+ C C
Sbjct: 882 KLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTAC 941
Query: 1376 PLGFLLANDSKTCEDIDECDIL-GSCSQ-HCYNMRGSFRCSCDTGYMLESDGRTC 1428
P G L TCED++EC++ G C C N +GSF C C G L+ GR C
Sbjct: 942 PRG-LARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
Score = 73.2 bits (178), Expect = 6e-12
Identities = 73/288 (25%), Positives = 98/288 (34%), Gaps = 57/288 (19%)
Query: 2913 CDGGRCI-PSEWICDG---DNDCGDMSDEDKRHQCQNQN-CSDSEFLCVNDRPPDRRCIP 2967
C G C P+ C + CG S + +C N C+D C
Sbjct: 119 CGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYI------- 171
Query: 2968 QSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
C G C +G C N C YG P+ R R C + + C
Sbjct: 172 -GTYC-GQPVCENGCQNGGRCI----GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMC 225
Query: 3028 LYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRC 3087
Q Q T VC + C H C CP C G
Sbjct: 226 ------QGQLT---------GIVCTKTLCCATIGRAWGHPCEM----CPAQPQPCRRGFI 266
Query: 3088 IEMMK-LCNHLDDCLDNSDEKGCGINECHDPSISGCDH--NCTDTLTSFYCSCRPGYKLM 3144
+ C +D+C +I G NC +T+ SF C C G+K
Sbjct: 267 PNIRTGACQDVDEC----------------QAIPGICQGGNCINTVGSFECRCPAGHKQS 310
Query: 3145 SDKRTCVDIDECTEMPFVC-SQKCENVIGSYICKCAPGYLREPDGKTC 3191
+ C DIDEC+ +P +C + +C N +GSY C C GY+ DG C
Sbjct: 311 ETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
Score = 73.2 bits (178), Expect = 6e-12
Identities = 83/320 (25%), Positives = 113/320 (35%), Gaps = 61/320 (19%)
Query: 115 CSNGQCIPS--EYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRD 172
C+NG CI +RC+ CP G ND CE D C N C DC +
Sbjct: 1819 CANGVCINQIGSFRCE----CPTGFSYNDLLL-VCE----DIDECSNGDNLCQRNADCIN 1869
Query: 173 SSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSG 232
S C C NG C+ R + N C H G YQ C +G
Sbjct: 1870 SPGSYRCE--CAAGFKLSPNGACVDRNECLEIPNVCS-----HGLCVDLQGSYQCICHNG 1922
Query: 233 -RCIYQNWVCDGEDDCKDNGDEDG------------CESGPH--------DVHKCSPREW 271
+ +C D+C+ + +G C G D+ +CS
Sbjct: 1923 FKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFG 1982
Query: 272 SCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTL-CSAL--NCQY-QCHETPYG 327
+GRC + G C E T GK C T C AL +C C
Sbjct: 1983 QVCRNGRCFNEI----GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGS 2038
Query: 328 GACFCPPGYIINHNDSRTCVEFDDC-QIWGIC-DQKCESRPGRHLCHCEEGYILE----- 380
C CPPGY + S C++ ++C + IC C + PG C C G++L
Sbjct: 2039 FRCICPPGYEVK---SENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRR 2095
Query: 381 ----RGQYCKANDSFGEASI 396
R +C N G+ S+
Sbjct: 2096 CFDTRQSFCFTNFENGKCSV 2115
Score = 69.7 bits (169), Expect = 6e-11
Identities = 102/447 (22%), Positives = 157/447 (35%), Gaps = 107/447 (23%)
Query: 27 ECDSAHFRCGSGHCIPADW-----------------RCDGTKDCSDD--------ADEIG 61
EC + C +G CI D RC T +CS + IG
Sbjct: 2174 ECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIG 2233
Query: 62 CAVVTCQQGY-----FKCQSEGQCIPNSWVC---------DQDQDCDDGSDERQD----- 102
C +G+ C+ +C N +C + C G R+D
Sbjct: 2234 SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCK 2293
Query: 103 ----CSQST--CSSHQITCSNGQCIPSEYRC---DHVRDCPDG---ADENDCQYPTCEQL 150
C++ C S + C N + + C + PDG DEN+C+ +
Sbjct: 2294 DLDECAEGLHDCESRGMMCKN---LIGTFMCICPPGMARRPDGEGCVDENECR---TKPG 2347
Query: 151 TCDNGACYNT--SQKCDWKVDCRDSSDEINCTE----ICLHN------EFSCGNGECIPR 198
C+NG C N S +C+ + SS C + +C + + + + +
Sbjct: 2348 ICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTK 2407
Query: 199 AYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGED--DCK------DN 250
+ C D G C P Y+ CP G + DG D +CK N
Sbjct: 2408 SECCC-DGGRGWGHQCELCPLPGTAQYKKICPHG----PGYTTDGRDIDECKVMPNLCTN 2462
Query: 251 GD--------EDGCESG-PHDVHKCSPREWS-CPESGR-CISIYKVCDGILDCPGREDEN 299
G C+ G D+ S + C +S + C I K +G C
Sbjct: 2463 GQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYV 2522
Query: 300 NTSTGKYCS-MTLCSAL--NCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW- 355
GK C + C NCQ+ C T G C CPPG+ +H C++ ++C
Sbjct: 2523 LQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT---ACIDNNECGSQP 2579
Query: 356 GICDQK--CESRPGRHLCHCEEGYILE 380
+C K C++ PG C C+ G+ L+
Sbjct: 2580 SLCGAKGICQNTPGSFSCECQRGFSLD 2606
Score = 64.7 bits (156), Expect = 2e-09
Identities = 76/306 (24%), Positives = 109/306 (35%), Gaps = 73/306 (23%)
Query: 1132 NDCGDGSDEK----NCNS---TETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCV 1184
N CGDG + C+S + TC + RC++ D C G +G
Sbjct: 117 NSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGY--IGTY 174
Query: 1185 LNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICI 1244
+ C +G +CIG NRC V+ T P QC+ D
Sbjct: 175 CGQPVCENGCQNGGRCIG-PNRCACVYGF----------TGP---------QCERDYRTG 214
Query: 1245 PNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKD 1304
P F + + G C C ++ I RAW + C +
Sbjct: 215 PCFTQVNNQ--MCQGQLTGIVCTKTLCCAT---------IGRAW----GHPC------EM 253
Query: 1305 CPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHEC 1364
CP QP C + C ++ C I +C G +C + G
Sbjct: 254 CPAQPQPCRRGFIPNIRTGACQDVDE-CQAI---------PGICQGGNCINTVGSF---- 299
Query: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDIL-GSC-SQHCYNMRGSFRCSCDTGYMLE 1422
+C CP G + ++ CEDIDEC I+ G C + C N GS+ C C GY+
Sbjct: 300 -------ECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTS 352
Query: 1423 SDGRTC 1428
+DG C
Sbjct: 353 TDGSRC 358
Score = 64.7 bits (156), Expect = 2e-09
Identities = 105/455 (23%), Positives = 154/455 (33%), Gaps = 88/455 (19%)
Query: 10 CTLLLALVACLAPAS------GQEC-DSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
C L+ C+ P G+ C D R G C + RC + IG
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC--ENGRC---------VNIIGS 2360
Query: 63 AVVTCQQGYFKCQSEGQCIPN-SWVCDQD---QDCDDGSDERQDCSQSTCSSHQITCSNG 118
C +G+ S +C+ N +C + C S R ++S C
Sbjct: 2361 YRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH 2420
Query: 119 QC--IPSEYRCDHVRDCP-------DGADENDCQYPTCEQLTCDNGACYNT--SQKCDWK 167
QC P + + CP DG D ++C+ C NG C NT S +C K
Sbjct: 2421 QCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPN---LCTNGQCINTMGSFRCFCK 2477
Query: 168 V---------DCRD----SSDEINCTEICLHNEFSCGNGEC-IPRAYVCDHDND-CQDGS 212
V C D S C IC + E G+ +C PR YV D C+D
Sbjct: 2478 VGYTTDISGTSCIDLDECSQSPKPCNYICKNTE---GSYQCSCPRGYVLQEDGKTCKDLD 2534
Query: 213 D----EHACNY---PTCGGYQFTCPSGRCIYQNWVCDGEDDCKDN----GDEDGCESGPH 261
+ +H C + T GG+ CP G + C ++C G + C++ P
Sbjct: 2535 ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT-ACIDNNECGSQPSLCGAKGICQNTPG 2593
Query: 262 DVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTL---------- 311
R +S +G CDG C + N G C
Sbjct: 2594 SFSCECQRGFSLDATGLNCEDVDECDGNHRC--QHGCQNILGGYRCGCPQGYIQHYQWNQ 2651
Query: 312 ------CSALNC--QYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW-GICDQKC 362
CS N C+ T C CP G+ + S C + ++C C+ C
Sbjct: 2652 CVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSS-ACHDVNECSSSKNPCNYGC 2710
Query: 363 ESRPGRHLCHCEEGYILERGQYCKANDSFGEASII 397
+ G +LC C GY +C + F + +
Sbjct: 2711 SNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYL 2745
Score = 63.9 bits (154), Expect = 3e-09
Identities = 89/384 (23%), Positives = 138/384 (35%), Gaps = 75/384 (19%)
Query: 19 CLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEG 78
C+ S C+ C G+ A+ C +C+ + G V T Y KC +
Sbjct: 510 CIPTVSSYRCE-----CNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGF 564
Query: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSE--YRC------DHV 130
Q P C D D+ C + + C NG+C+ ++ ++C +
Sbjct: 565 QRTPTKQACI---DIDE------------CIQNGVLCKNGRCVNTDGSFQCICNAGFELT 609
Query: 131 RDCPDGADENDCQYPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEINCTEIC-LHNE 187
D + D ++C C NG C N S KC K + + CT++
Sbjct: 610 TDGKNCVDHDECTTTNM----CLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTP 665
Query: 188 FSCGNGECIPR--AYVCDHDNDCQDGSDEHAC----NYPTCGGYQFTCPSGRCI--YQNW 239
C NG CI ++ CD G D C TC G G C+ +
Sbjct: 666 GICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYG---GIKKGVCVRPFPGA 722
Query: 240 VCDGEDDCK--DNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGI-LDCPGRE 296
V E C D G + C+ P + S G C S G+ + GR+
Sbjct: 723 VTKSECCCANPDYGFGEPCQP--------CPAKNSAEFHGLCSS------GVGITVDGRD 768
Query: 297 DENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWG 356
C+ +C L Y+C+ C GY + + R C++ D+C +
Sbjct: 769 INECALDPDICANGICENLRGSYRCN---------CNSGYEPDAS-GRNCIDIDECLVNR 818
Query: 357 I-CDQK-CESRPGRHLCHCEEGYI 378
+ CD C + PG + C C GY+
Sbjct: 819 LLCDNGLCRNTPGSYSCTCPPGYV 842
Score = 62.0 bits (149), Expect = 1e-08
Identities = 47/146 (32%), Positives = 62/146 (42%), Gaps = 8/146 (5%)
Query: 3905 GVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELG-CN 3963
GV G G T T C + C NG CIP + + G D G C
Sbjct: 475 GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCI 534
Query: 3964 KGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH--C 4021
E C N C G + C C AGF+ + +C+DI+EC Q G ++ C
Sbjct: 535 DVDE--CTSNPCTNGDCVNTPGSYYCKCHAGFQRTP-TKQACIDIDECIQNGVLCKNGRC 591
Query: 4022 RNTKGSYECVCADGFTSMSDRPGKRC 4047
NT GS++C+C GF +D GK C
Sbjct: 592 VNTDGSFQCICNAGFELTTD--GKNC 615
Score = 61.6 bits (148), Expect = 2e-08
Identities = 62/276 (22%), Positives = 88/276 (31%), Gaps = 93/276 (33%)
Query: 108 CSSHQITCSNGQCIP--SEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNT--SQK 163
C H C NG+CIP S YRC+ A+ + C C NG C NT S
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYY 557
Query: 164 CDWKVDCRDSSDEINCTEI--CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT 221
C + + + C +I C+ N C NG C+ DGS + CN
Sbjct: 558 CKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVN-----------TDGSFQCICN--- 603
Query: 222 CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCIS 281
G++ T C+ D D C
Sbjct: 604 -AGFELTTDGKNCV----------------DHDEC------------------------- 621
Query: 282 IYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHN 341
+T C +C + ++C C PG+++ N
Sbjct: 622 --------------------TTTNMCLNGMCINEDGSFKC---------ICKPGFVLAPN 652
Query: 342 DSRTCVEFDDCQIWGIC-DQKCESRPGRHLCHCEEG 376
R C + D+CQ GIC + C + G C C G
Sbjct: 653 -GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPG 687
Score = 61.6 bits (148), Expect = 2e-08
Identities = 120/493 (24%), Positives = 163/493 (33%), Gaps = 114/493 (23%)
Query: 998 CGCPYGMRLASNHLTC----EGDPTNEPPTEQC----GLFSFPCKNGRCV-PNYYLCDGV 1048
C C G L ++ C E TN C G F CK G + PN C V
Sbjct: 600 CICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDV 659
Query: 1049 DDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAH--WRCDKRNDCVDGSDEHNC-PTHA 1105
D+C C +G CI + +RCD G D C TH
Sbjct: 660 DECQTPG-----------------ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHM 702
Query: 1106 PASCLD--TQYTCDNH--QCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRC 1161
++C + C ++K+ C + D G G E CQP CP
Sbjct: 703 RSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG---------EPCQP----CPAKNS 749
Query: 1162 IDLSFVCD-GDKDCVDGSDEVGCVL-------------------NCTASQFKCASGDKCI 1201
+ +C G VDG D C L NC + ASG CI
Sbjct: 750 AEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI 809
Query: 1202 GV----TNR--CDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPD 1255
+ NR CD C + C T PPG E + ED EC+ +P
Sbjct: 810 DIDECLVNRLLCDNGL-CRNTPGSYSC-TCPPGYVFRTETETCED------INECESNP- 860
Query: 1256 CLYGSDEHNA------CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDC-----GDMSDEKD 1304
C+ G+ +N C P + SS + WL +D+ C G +
Sbjct: 861 CVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSEC 920
Query: 1305 CPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTD--ESPLCNG-NSCSDFNGGCT 1361
C T +W C C+ CP G + C N C F G C
Sbjct: 921 CATLG---AAWGSPCER----------CELDTACPRGLARIKGVTCEDVNECEVFPGVCP 967
Query: 1362 H-ECVQEPFGAKCLCPLGFLLANDSKTCEDI--DECDILGSCSQHCYNMRGSFR---CSC 1415
+ CV C CP G L + C DI ++C + + + + G FR C C
Sbjct: 968 NGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCC 1027
Query: 1416 DTGYMLESDGRTC 1428
G ++ C
Sbjct: 1028 AVGAAWGTECEEC 1040
Score = 59.7 bits (143), Expect = 7e-08
Identities = 107/460 (23%), Positives = 151/460 (32%), Gaps = 111/460 (24%)
Query: 19 CLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEG 78
C+ C+ C +G + + C +C + + + QG ++C
Sbjct: 1867 CINSPGSYRCE-----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICH- 1920
Query: 79 QCIPNSWVCDQDQD-CDDGSD-ERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDG 136
N + QDQ C D + ER C TC + + N C P + H DC D
Sbjct: 1921 ----NGFKASQDQTMCMDVDECERHPCGNGTCKN-TVGSYNCLCYPG-FELTHNNDCLD- 1973
Query: 137 ADENDCQYPTCEQLTCDNGACYNT--SQKCDWKVDCRDSSDEINC--TEICLHNEFSCGN 192
DE + C NG C+N S KC + D NC T C+ SC
Sbjct: 1974 IDECSSFFGQ----VCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSP 2029
Query: 193 GEC----------IPRAYV-----CDHDNDCQDGSDEHACNYPTC----GGYQFTCPSGR 233
G C P Y C N+C + D + C + +C GG+Q CP G
Sbjct: 2030 GTCQNLEGSFRCICPPGYEVKSENCIDINECDE--DPNICLFGSCTNTPGGFQCLCPPGF 2087
Query: 234 CIYQNW---VCDGEDDCKDNGDEDGCESGPHDVH----KCS----PRE-WS-----CPES 276
+ N + C N + C S P + KC P E W CP+
Sbjct: 2088 VLSDNGRRCFDTRQSFCFTNFENGKC-SVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKD 2146
Query: 277 GRCISIYKVCD-GILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPG 335
++ +C G P D S +CS QC T C CP G
Sbjct: 2147 DE-VAFQDLCPYGHGTVPSLHDTREDVNECLESPGICS----NGQCINTDGSFRCECPMG 2201
Query: 336 YIINHNDSRTCVEFDDCQIWG--------------------------------------- 356
Y +++ R CV+ D+C I
Sbjct: 2202 YNLDYTGVR-CVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQN 2260
Query: 357 --ICDQKCESRPGRHLCHCEEGYILERGQ-YCKANDSFGE 393
+C +C + G + C C GY L Q CK D E
Sbjct: 2261 PLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE 2300
Score = 57.8 bits (138), Expect = 3e-07
Identities = 100/420 (23%), Positives = 148/420 (35%), Gaps = 76/420 (18%)
Query: 27 ECDSAHFRCGSGHCIP--ADWRCDGTKDCSDDADEIGCAVVT-CQQGYFKCQSEGQCIPN 83
EC + C +G C+ ++C D GC + C C ++
Sbjct: 1203 ECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262
Query: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC--IPSEYRCDHVRDCPDG----- 136
S+ C + D R C ++ C GQC IP EYRC C DG
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCL----CYDGFMASM 1318
Query: 137 -----ADENDCQYPTCEQLTCDNGACYNTSQK--CDWKVDCRDSSDEINCT-----EICL 184
D N+C C G C NT C ++ CT EI
Sbjct: 1319 DMKTCIDVNECDL---NSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
Query: 185 HN---EFSC----GNGEC------IPRAYVCDHDNDCQDGSDEHACNYP---TCGGYQFT 228
HN SC G+ +C I C ++C +G+ + + N T G Y+
Sbjct: 1376 HNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA 1435
Query: 229 CPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP----HDVHKC--------SPREWSCPES 276
C G + C D+C +N + CE+G ++C + SC +
Sbjct: 1436 CSEG-FTGDGFTCSDVDECAENINL--CENGQCLNVPGAYRCECEMGFTPASDSRSCQDI 1492
Query: 277 GRC----ISIYKVCD---GILDCPGREDENNTSTGKYCS-MTLCS-ALNC-QYQCHETPY 326
C I ++ C+ G+ C + TG C+ + C+ +NC C TP
Sbjct: 1493 DECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPG 1552
Query: 327 GGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESR-PGRHLCHCEEGYILERGQYC 385
C CPP + +N T V D ++ G C K R G C+ E G + R C
Sbjct: 1553 RYECNCPPDFQLN----PTGVGCVDNRV-GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC 1607
Score = 54.7 bits (130), Expect = 2e-06
Identities = 78/379 (20%), Positives = 126/379 (33%), Gaps = 75/379 (19%)
Query: 18 ACLAPASGQECDSAHFRCGSG-HCIPADWRCDGTKDCSDDADEI---GCAVVTCQQGY-- 71
+CL +C G+G CI D +GT CS +A + G C +G+
Sbjct: 1383 SCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTG 1442
Query: 72 --FKCQSEGQCIPNSWVCDQDQ----------DCDDG---SDERQDCSQSTCSSHQITCS 116
F C +C N +C+ Q +C+ G + + + C S Q C
Sbjct: 1443 DGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICV 1502
Query: 117 NGQC--IPSEYRCDHVRDCPDG----------ADENDCQYPTCEQLTCDNGACYNTSQK- 163
G C +P + C C DG D ++C P + C NG C NT +
Sbjct: 1503 FGTCNNLPGMFHCI----CDDGYELDRTGGNCTDIDECADP----INCVNGLCVNTPGRY 1554
Query: 164 -CDWKVDCRDSSDEINCTEICLHN-----------EFSCGN--GECIPRAYVCDHDNDCQ 209
C+ D + + + C + + N SC G + R+ C
Sbjct: 1555 ECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAW 1614
Query: 210 DGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPR 269
G+ C Y CP G N + +D + + G G + ++
Sbjct: 1615 -GNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSF 1673
Query: 270 EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGA 329
+ CP+ ++C+ I +C T C+ T
Sbjct: 1674 QCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-----------------CYNTLGNYT 1716
Query: 330 CFCPPGYIINHNDSRTCVE 348
C CPP Y + N C++
Sbjct: 1717 CICPPEY-MQVNGGHNCMD 1734
Score = 51.6 bits (122), Expect = 2e-05
Identities = 77/317 (24%), Positives = 100/317 (31%), Gaps = 53/317 (16%)
Query: 3741 GQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHP 3800
G N CG C + +C+ C N CGD R M TC
Sbjct: 85 GPNVCGSRFHSYCCPGWKTLPGGNQCIVPIC---------RNSCGDGFCSRP-NMCTCSS 134
Query: 3801 EYFQCTSGH--CVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFE--CKNHVCIP 3856
T G ++C C D D C + G YC + E C+N
Sbjct: 135 GQISSTCGSKSIQQCSVRCMNGGTCAD--DHCQCQKGYI-GTYCGQPVCENGCQNG---- 187
Query: 3857 PYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCI--YSHEVCNGVDDCGDGTD 3914
+C G + C C P + +N C + VC C
Sbjct: 188 --GRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGR 245
Query: 3915 ETEEHCRKPTPKPCTEYEYKCGNGHCIPH--DNVCDDADDCGDWSDELGCNKGKERTCAE 3972
C C C G IP+ C D D+C
Sbjct: 246 AWGHPCEM-----CPAQPQPCRRGF-IPNIRTGACQDVDEC---------------QAIP 284
Query: 3973 NICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQF-GTCPQ-HCRNTKGSYEC 4030
IC+ G F C C AG + + + C DI+EC G C C NT GSY C
Sbjct: 285 GICQGGNCINTVGSFECRCPAGHKQSETTQ-KCEDIDECSIIPGICETGECSNTVGSYFC 343
Query: 4031 VCADGFTSMSDRPGKRC 4047
VC G+ + +D G RC
Sbjct: 344 VCPRGYVTSTD--GSRC 358
Score = 50.4 bits (119), Expect = 4e-05
Identities = 94/380 (24%), Positives = 123/380 (32%), Gaps = 103/380 (27%)
Query: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCT------THTCSSSEFQCASGR 2875
C G+ N CI V +C N CGD P CT + TC S Q S R
Sbjct: 97 CCPGWKTLPGGNQCI--VPICR--NSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVR 152
Query: 2876 CIPQHWYCDQETDCFDASDEPASCGH--SERTCLADEFKCDGGRCIPSEWICDGDNDCGD 2933
C+ D C CG E C +GGRCI G N C
Sbjct: 153 CMNGGTCADDHCQC-QKGYIGTYCGQPVCENGCQ------NGGRCI-------GPNRCAC 198
Query: 2934 MSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQ--SWVCDGDVDC-TDGYDENQNCTR 2990
+ QC+ + F VN ++ C Q VC + C T G C
Sbjct: 199 VYG-FTGPQCERDYRTGPCFTQVN----NQMCQGQLTGIVCTKTLCCATIGRAWGHPC-- 251
Query: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
C C G IP I R C D + CQ CQ G CI+
Sbjct: 252 EMCPAQPQPCRRGF-IPNI----RTGACQDVDE--------CQAIPGICQGGNCIN---- 294
Query: 3051 CDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNG-RCIEMMKLCNHLDDC--LDNSDEK 3107
T E +C G + E + C +D+C + E
Sbjct: 295 -----------------------TVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICET 331
Query: 3108 GCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFV----- 3162
G C++T+ S++C C GY +D C ID+ T M F
Sbjct: 332 G----------------ECSNTVGSYFCVCPRGYVTSTDGSRC--IDQRTGMCFSGLVNG 373
Query: 3163 -CSQKCENVIGSYICKCAPG 3181
C+Q+ + C C PG
Sbjct: 374 RCAQELPGRMTKMQCCCEPG 393
Score = 48.9 bits (115), Expect = 1e-04
Identities = 76/312 (24%), Positives = 106/312 (33%), Gaps = 74/312 (23%)
Query: 125 YRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICL 184
Y C + P G N C P C +C +G C + C SS +I+ T C
Sbjct: 96 YCCPGWKTLPGG---NQCIVPICRN-SCGDGFCSRPNM-------CTCSSGQISST--CG 142
Query: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTC------GG-----------YQF 227
+ C+ D CQ G C P C GG Y F
Sbjct: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGF 202
Query: 228 TCP-------SGRCIYQ--NWVCDGEDD---------CKDNGDEDG--CESGPHDVHKC- 266
T P +G C Q N +C G+ C G G CE P C
Sbjct: 203 TGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCR 262
Query: 267 -----SPREWSCPESGRCISIYKVCDG----------ILDCPGREDENNTSTGKYCSMTL 311
+ R +C + C +I +C G CP ++ T T K +
Sbjct: 263 RGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSET-TQKCEDIDE 321
Query: 312 CSALN--CQY-QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKC-ESRPG 367
CS + C+ +C T C CP GY+ + + SR + G+ + +C + PG
Sbjct: 322 CSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPG 381
Query: 368 RHL---CHCEEG 376
R C CE G
Sbjct: 382 RMTKMQCCCEPG 393
Score = 47.8 bits (112), Expect = 3e-04
Identities = 91/397 (22%), Positives = 142/397 (35%), Gaps = 81/397 (20%)
Query: 27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
EC C G+CI + G C QGY+ + C
Sbjct: 1653 ECQELPGLCQGGNCI----------------NTFGSFQCECPQGYYLSEDTRIC------ 1690
Query: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCI-PSEY-RCDHVRDCPDGADENDCQY 144
+D D+ C TC + T N CI P EY + + +C D ++ C Y
Sbjct: 1691 ----EDIDECFAHPGVCGPGTCYN---TLGNYTCICPPEYMQVNGGHNCMD-MRKSFC-Y 1741
Query: 145 PTCEQLTCDNGACYNTSQK---CDWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAY 200
+ TC+N +N +++ C + V + C T + CGN IP
Sbjct: 1742 RSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN---IPGFT 1798
Query: 201 VCDHDNDCQDGSD----EHACNYPTC----GGYQFTCPSGRCIYQNW--VCDGEDDCKDN 250
H D + C C G ++ CP+G Y + VC+ D+C N
Sbjct: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFS-YNDLLLVCEDIDECS-N 1856
Query: 251 GDEDGCESGPHDVHKCSPREWSCP-ESGRCISIYKVCDGILDCPGREDENNTSTGKYCSM 309
GD + C+ ++ SP + C +G +S C +C CS
Sbjct: 1857 GD-NLCQRNADCIN--SPGSYRCECAAGFKLSPNGACVDRNEC--------LEIPNVCSH 1905
Query: 310 TLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRH 369
LC L YQC C G+ + D C++ D+C+ + C++ G +
Sbjct: 1906 GLCVDLQGSYQC---------ICHNGFKASQ-DQTMCMDVDECERHPCGNGTCKNTVGSY 1955
Query: 370 LCHCEEGYILERGQYC----KANDSFGEASIIFSNGR 402
C C G+ L C + + FG+ + NGR
Sbjct: 1956 NCLCYPGFELTHNNDCLDIDECSSFFGQ---VCRNGR 1989
Score = 47.4 bits (111), Expect = 3e-04
Identities = 80/395 (20%), Positives = 133/395 (33%), Gaps = 85/395 (21%)
Query: 942 ADGGEMTVIRSGIAY------ILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPN-- 993
+ G E R G+ + I + S N+ T S C G C P+P
Sbjct: 2373 SSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC-PLPGTA 2431
Query: 994 -FQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNY---------- 1042
++++C P+G G T+ ++C + C NG+C+
Sbjct: 2432 QYKKIC--PHG----------PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVG 2479
Query: 1043 -------YLCDGVDDCHDNSDEQLCGTL-NNTCSSSAFTCGHGECIPAHWR-CDKRNDCV 1093
C +D+C + + C + NT S +C G + + C ++C
Sbjct: 2480 YTTDISGTSCIDLDEC--SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQ 2537
Query: 1094 DGSDEHNCPTHAPASCLDTQ--YTCDNHQCISKNWV-CDTDNDCGDGSDEKNCNSTETCQ 1150
+ +HNC C++T +TC +++ C +N+CG S C + CQ
Sbjct: 2538 --TKQHNCQF----LCVNTLGGFTCKCPPGFTQHHTACIDNNECG--SQPSLCGAKGICQ 2589
Query: 1151 --PSQFNCPNHRCIDLSFV---------CDGDKDCVDGSDEV--GCVLNCTASQFKCASG 1197
P F+C R L CDG+ C G + G C +
Sbjct: 2590 NTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQW 2649
Query: 1198 DKCIGVTNRCDGVFDCSD-------NSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWEC 1250
++C+ N C C S + CP+ F + + EC
Sbjct: 2650 NQCVD-ENECSNPNACGSASCYNTLGSYKCACPSG---------FSFDQFSSACHDVNEC 2699
Query: 1251 DGHPD-CLYGSDEHNACVPKTCPSSYFHCDNGNCI 1284
+ C YG CP Y+ G+C+
Sbjct: 2700 SSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCV 2734
Score = 47.0 bits (110), Expect = 4e-04
Identities = 96/427 (22%), Positives = 147/427 (34%), Gaps = 114/427 (26%)
Query: 3467 NPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMP---------------- 3510
N C T G C + + G + CEC + F++ S T C+
Sbjct: 2340 NECRTKPGICENGRCVNIIGS-YRCECNEGFQSS--SSGTECLDNRQGLCFAEVLQTICQ 2396
Query: 3511 MCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCP-------QRFCRLGQFQCSDG 3563
M SS++ L +E C CDG + + LCP ++ C G +DG
Sbjct: 2397 MASSSRNLVTKSECC------CDGGRGWGH---QCELCPLPGTAQYKKICPHGPGYTTDG 2447
Query: 3564 N----CTSPQTLCNAHQNCPDGSDEDRLLCENHHC---------DSNEWQCANKRC---- 3606
C LC Q C + R C+ + D +E + K C
Sbjct: 2448 RDIDECKVMPNLCTNGQ-CINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYIC 2506
Query: 3607 --IPESWQCDT------FNDCEDNSDEDSSHCASRTCRPGQFRCANG------RCIPQAW 3652
S+QC D + D D C QF C N +C P
Sbjct: 2507 KNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC---QFLCVNTLGGFTCKCPPGFT 2563
Query: 3653 K----CDVDNDCGDHSDEPIEECMSSAHLCDNFT-EFSCKTN--YRCIPKWAVCNGVDDC 3705
+ C +N+CG + +C N FSC+ + C VD+C
Sbjct: 2564 QHHTACIDNNECGSQPS-----LCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC 2618
Query: 3706 RDNSD-EQGCEERTCHPVGDFRC--KNHHCIPLRW-QCDGQNDCGDNSDEENCAPREC-- 3759
N + GC+ + +G +RC + +W QC +N+C S+ C C
Sbjct: 2619 DGNHRCQHGCQ----NILGGYRCGCPQGYIQHYQWNQCVDENEC---SNPNACGSASCYN 2671
Query: 3760 TESEFRCVNQQCIPSRWICDHYND-CGD----NSDERDCE----------MRTCHPEYFQ 3804
T ++C PS + D ++ C D +S + C + C P Y++
Sbjct: 2672 TLGSYKCA----CPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYR 2727
Query: 3805 CTSGHCV 3811
GHCV
Sbjct: 2728 VGQGHCV 2734
Score = 45.8 bits (107), Expect = 0.001
Identities = 60/278 (21%), Positives = 87/278 (31%), Gaps = 68/278 (24%)
Query: 1165 SFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPT 1224
S+ C G K G+ C + + GD N C CS + C +
Sbjct: 95 SYCCPGWKTLPGGNQ-------CIVPICRNSCGDGFCSRPNMCT----CSSGQISSTCGS 143
Query: 1225 RPPGMCHSDEFQCQEDGICIPNFWECD--------GHPDCLYGSDEHNACV-PKTCPSSY 1275
+ C +C G C + +C G P C G C+ P C Y
Sbjct: 144 KSIQQC---SVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVY 200
Query: 1276 FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVN--LSVVCD 1333
C+RD G C TQ + + +C +VC
Sbjct: 201 GFTGPQ--------CERDYRTGP------CFTQ-----------VNNQMCQGQLTGIVCT 235
Query: 1334 GIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDE 1393
LC C+ H C P + C GF+ + C+D+DE
Sbjct: 236 -----------KTLC----CATIGRAWGHPCEMCPAQPQP-CRRGFIPNIRTGACQDVDE 279
Query: 1394 CDILGSCSQ--HCYNMRGSFRCSCDTGYMLESDGRTCK 1429
C + Q +C N GSF C C G+ + C+
Sbjct: 280 CQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCE 317
Score = 42.4 bits (98), Expect = 0.011
Identities = 116/597 (19%), Positives = 192/597 (32%), Gaps = 143/597 (23%)
Query: 3465 VSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEK 3524
+ NPCG NG C+++ F C C + F + + C+ LCA +
Sbjct: 2219 IGNPCG--NGTCTNVI------GSFECNCNEGFEPGPMMNCED-INECAQNPLLCAF--R 2267
Query: 3525 CIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDG--NCTSPQTLCNAHQN----- 3577
C+ + G +C+ Q+ C+ +C++G +C S +C
Sbjct: 2268 CMNTF----GSYECTCPIGYALREDQKMCK-DLDECAEGLHDCESRGMMCKNLIGTFMCI 2322
Query: 3578 CPDGS----DEDRLLCENHHCDSNEWQCANKRCIP--ESWQCDTFNDCEDNS------DE 3625
CP G D + + EN C + C N RC+ S++C+ + +S D
Sbjct: 2323 CPPGMARRPDGEGCVDENE-CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDN 2381
Query: 3626 DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCG-DHSDE------------------ 3666
C + + ++ R + +C D G H E
Sbjct: 2382 RQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGP 2441
Query: 3667 -------PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAV--------CNGVDDCR----- 3706
I+EC +LC N + ++RC K C +D+C
Sbjct: 2442 GYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKP 2501
Query: 3707 --------DNSDEQGC--------EERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSD 3750
+ S + C + +TC + + + K H+C L G C
Sbjct: 2502 CNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTC----- 2556
Query: 3751 EENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGH 3809
C P T+ C+ N +C +C C + CE C + +G
Sbjct: 2557 --KCPPG-FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCE---CQRGFSLDATGL 2610
Query: 3810 CVHSELKCDGSADCLDASDE------ADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDG 3863
+CDG+ C CP Y Q + + C+ +C
Sbjct: 2611 NCEDVDECDGNHRCQHGCQNILGGYRCGCPQ-----GYIQHYQW----NQCVDEN-ECSN 2660
Query: 3864 DDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEH--CR 3921
+ CG S C S F ++ C +E + + C G TE C
Sbjct: 2661 PNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCG 2720
Query: 3922 KPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQN 3978
C Y+ G GHC+ +G NKG+ + + E+N
Sbjct: 2721 ------CPPGYYRVGQGHCV----------------SGMGFNKGQYLSLDTEVDEEN 2755
Score = 40.4 bits (93), Expect = 0.041
Identities = 51/203 (25%), Positives = 73/203 (35%), Gaps = 56/203 (27%)
Query: 3464 IVSNPCGTNNG--GCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCAN 3521
I +N CG+ G +C PG F+CEC F +L +G C
Sbjct: 2570 IDNNECGSQPSLCGAKGICQNTPGS--FSCECQRGF-SLDATGLN-----CEDVD----- 2616
Query: 3522 NEKCIPIWWKCDGQKDCSDGSDEL-----ALCPQRFCRLGQF-QCSDGN-CTSP------ 3568
+CDG C G + CPQ + + Q+ QC D N C++P
Sbjct: 2617 ---------ECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSA 2667
Query: 3569 ---QTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
TL + CP G D+ H D NE + C ++ C ++ E
Sbjct: 2668 SCYNTLGSYKCACPSGFSFDQFSSACH--DVNECSSSKNPC---NYGC--------SNTE 2714
Query: 3626 DSSHCASRTCRPGQFRCANGRCI 3648
C C PG +R G C+
Sbjct: 2715 GGYLCG---CPPGYYRVGQGHCV 2734
Score = 38.9 bits (89), Expect = 0.12
Identities = 25/85 (29%), Positives = 34/85 (40%), Gaps = 18/85 (21%)
Query: 4327 NKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEG-STTECDAAIELPINLPPPCRCMH 4385
N+ + +C+ C RP +C+ Q SS S +C RCM+
Sbjct: 108 NQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSV------------RCMN 155
Query: 4386 GGNCYFDETDLPKCKCPSGYTGKYC 4410
GG C D C+C GY G YC
Sbjct: 156 GGTCADDH-----CQCQKGYIGTYC 175
Score = 37.7 bits (86), Expect = 0.27
Identities = 21/53 (39%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 2017 ESSNGCSNNMNACQQI--CLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVV 2067
E + CSN N CQ+ C+ PG + C CA GFKL+P N +C N + +
Sbjct: 1849 EDIDECSNGDNLCQRNADCINSPGS-YRCECAAGFKLSP-NGACVDRNECLEI 1899
Score = 36.2 bits (82), Expect = 0.78
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 10/81 (12%)
Query: 4329 SVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGN 4388
S P+LC +C PG +SC C +G S ++ + C+ E N RC HG
Sbjct: 2577 SQPSLCG--AKGICQNTPGSFSCECQRGFS-LDATGLNCEDVDECDGN----HRCQHGCQ 2629
Query: 4389 CYFDETDLPKCKCPSGYTGKY 4409
+C CP GY Y
Sbjct: 2630 NILGGY---RCGCPQGYIQHY 2647
Score = 35.8 bits (81), Expect = 1.0
Identities = 17/38 (44%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 2022 CSNNMNACQQ-ICLPVPGGLFSCACATGFKLNPDNRSC 2058
C+ N+N C+ CL VPG + C C GF D+RSC
Sbjct: 1453 CAENINLCENGQCLNVPGA-YRCECEMGFTPASDSRSC 1489
Score = 34.7 bits (78), Expect = 2.3
Identities = 22/84 (26%), Positives = 34/84 (40%), Gaps = 3/84 (3%)
Query: 320 QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGY-I 378
+C T C C GY + N C++ D+C + C + PG + C C G+
Sbjct: 509 RCIPTVSSYRCECNMGYKQDANGD--CIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQR 566
Query: 379 LERGQYCKANDSFGEASIIFSNGR 402
Q C D + ++ NGR
Sbjct: 567 TPTKQACIDIDECIQNGVLCKNGR 590
Score = 33.9 bits (76), Expect = 3.9
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 9/70 (12%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIEG-STTECDAAIELPINLPPPCRCMHGGNCYFDETDL 4396
C H C GGY C CPQG +I+ +C E + P C G ++
Sbjct: 2624 CQHGCQNILGGYRCGCPQG--YIQHYQWNQC--VDENECSNPNAC----GSASCYNTLGS 2675
Query: 4397 PKCKCPSGYT 4406
KC CPSG++
Sbjct: 2676 YKCACPSGFS 2685
Score = 33.5 bits (75), Expect = 5.1
Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 16/107 (14%)
Query: 3457 YHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQ 3516
++ + Q + N C N S C G + C CP F Q S + + + CSS++
Sbjct: 2646 HYQWNQCVDENECSNPNACGSASCYNTLGS--YKCACPSGFSFDQFSSACHDVNECSSSK 2703
Query: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDG 3563
C N C +G C CP + R+GQ C G
Sbjct: 2704 NPC--NYGCS----NTEGGYLCG--------CPPGYYRVGQGHCVSG 2736
Score = 33.5 bits (75), Expect = 5.1
Identities = 34/99 (34%), Positives = 42/99 (42%), Gaps = 25/99 (25%)
Query: 4329 SVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGST-----TECDAAIELPINLPPPCRC 4383
S PN C S C G Y CACP G SF + S+ EC ++ + P N C
Sbjct: 2659 SNPNACG---SASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSS-KNPCNY--GCSN 2712
Query: 4384 MHGGNCYFDETDLPKCKCPSGY--TGK-YC--EMAFSKG 4417
GG C CP GY G+ +C M F+KG
Sbjct: 2713 TEGGYL---------CGCPPGYYRVGQGHCVSGMGFNKG 2742
Score = 33.1 bits (74), Expect = 6.6
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 8/65 (12%)
Query: 4342 CLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKC 4401
C+ PG Y CAC +G + + ++ D E INL +C++ Y +C+C
Sbjct: 1425 CVNTPGSYRCACSEGFTGDGFTCSDVDECAE-NINLCENGQCLNVPGAY-------RCEC 1476
Query: 4402 PSGYT 4406
G+T
Sbjct: 1477 EMGFT 1481
Score = 32.7 bits (73), Expect = 8.6
Identities = 23/81 (28%), Positives = 35/81 (43%), Gaps = 15/81 (18%)
Query: 4328 KSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPC---RCM 4384
+++P +C+ C+ G + C CP G E +T +C+ E I +P C C
Sbjct: 281 QAIPGICQ---GGNCINTVGSFECRCPAGHKQSE-TTQKCEDIDECSI-IPGICETGECS 335
Query: 4385 HGGNCYFDETDLPKCKCPSGY 4405
+ YF C CP GY
Sbjct: 336 NTVGSYF-------CVCPRGY 349
Score = 32.7 bits (73), Expect = 8.6
Identities = 21/71 (29%), Positives = 28/71 (39%), Gaps = 11/71 (15%)
Query: 4338 CSHLCLLRPGGYSCACPQGSSFIEGSTT--ECDAAIELPINLPPPCRCMHGGNCYFDETD 4395
C+++C G Y C+CP+G E T + D N C GG
Sbjct: 2502 CNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF------- 2554
Query: 4396 LPKCKCPSGYT 4406
CKCP G+T
Sbjct: 2555 --TCKCPPGFT 2563
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.459
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 210,894,141
Number of Sequences: 37866
Number of extensions: 11245894
Number of successful extensions: 53362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 325
Number of HSP's that attempted gapping in prelim test: 25298
Number of HSP's gapped (non-prelim): 11972
length of query: 4655
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4531
effective length of database: 13,552,134
effective search space: 61404719154
effective search space used: 61404719154
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.