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Search of human proteins with 41327734
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327734 epidermal growth factor receptor isoform c
precursor [Homo sapiens]
(405 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327734 epidermal growth factor receptor isoform c precursor... 850 0.0
gi|29725609 epidermal growth factor receptor isoform a precursor... 847 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 847 0.0
gi|41327732 epidermal growth factor receptor isoform b precursor... 847 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 390 e-109
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 390 e-109
gi|54792096 erbB-2 isoform a [Homo sapiens] 363 e-100
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 352 3e-97
gi|54792098 erbB-2 isoform b [Homo sapiens] 351 8e-97
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 115 7e-26
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 115 7e-26
gi|54792102 erbB-3 isoform s precursor [Homo sapiens] 106 3e-23
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 94 3e-19
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 82 7e-16
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 55 1e-07
gi|108773804 Fraser syndrome 1 [Homo sapiens] 53 6e-07
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 51 2e-06
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 51 2e-06
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 51 2e-06
gi|28626521 zinc finger, NFX1-type containing 1 [Homo sapiens] 40 0.003
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 40 0.005
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 40 0.005
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 40 0.005
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 40 0.005
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 37 0.024
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 37 0.024
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 37 0.024
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu... 37 0.032
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu... 37 0.032
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 37 0.032
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 850 bits (2196), Expect = 0.0
Identities = 405/405 (100%), Positives = 405/405 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGLS 405
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGLS
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGLS 405
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 847 bits (2188), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 94.4 bits (233), Expect = 2e-19
Identities = 78/279 (27%), Positives = 117/279 (41%), Gaps = 51/279 (18%)
Query: 29 KVCQGTSNKLTQ---LGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD------ 75
K C+G K+ +G F+D LS+ + F NC + G+L I V D
Sbjct: 327 KKCEGPCRKVCNGIGIGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP 385
Query: 76 ------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYD 126
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 386 PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS--- 442
Query: 127 ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQ 181
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 443 ---LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSC 499
Query: 182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC---RGK-----SPSDC-- 231
G Q C C CWG +C + ++C +C G+ S+C
Sbjct: 500 KATG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQ 557
Query: 232 CHNQCA-----AGCTGPRESDCLVCRKFRDEATCKDTCP 265
CH +C CTG +C+ C + D C TCP
Sbjct: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCP 596
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 847 bits (2188), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 94.4 bits (233), Expect = 2e-19
Identities = 78/279 (27%), Positives = 117/279 (41%), Gaps = 51/279 (18%)
Query: 29 KVCQGTSNKLTQ---LGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD------ 75
K C+G K+ +G F+D LS+ + F NC + G+L I V D
Sbjct: 327 KKCEGPCRKVCNGIGIGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP 385
Query: 76 ------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYD 126
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 386 PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS--- 442
Query: 127 ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQ 181
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 443 ---LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSC 499
Query: 182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC---RGK-----SPSDC-- 231
G Q C C CWG +C + ++C +C G+ S+C
Sbjct: 500 KATG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQ 557
Query: 232 CHNQCA-----AGCTGPRESDCLVCRKFRDEATCKDTCP 265
CH +C CTG +C+ C + D C TCP
Sbjct: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCP 596
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 847 bits (2188), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 94.4 bits (233), Expect = 2e-19
Identities = 78/279 (27%), Positives = 117/279 (41%), Gaps = 51/279 (18%)
Query: 29 KVCQGTSNKLTQ---LGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD------ 75
K C+G K+ +G F+D LS+ + F NC + G+L I V D
Sbjct: 327 KKCEGPCRKVCNGIGIGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP 385
Query: 76 ------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYD 126
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 386 PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS--- 442
Query: 127 ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQ 181
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 443 ---LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSC 499
Query: 182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC---RGK-----SPSDC-- 231
G Q C C CWG +C + ++C +C G+ S+C
Sbjct: 500 KATG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQ 557
Query: 232 CHNQCA-----AGCTGPRESDCLVCRKFRDEATCKDTCP 265
CH +C CTG +C+ C + D C TCP
Sbjct: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCP 596
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 390 bits (1003), Expect = e-109
Identities = 179/380 (47%), Positives = 250/380 (65%), Gaps = 5/380 (1%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITG 403
+DP++L++ +TV+EITG
Sbjct: 381 IEAIDPEKLNVFRTVREITG 400
Score = 68.9 bits (167), Expect = 8e-12
Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 40/245 (16%)
Query: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
Query: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
Query: 160 ESIQWRDI---VSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
+I W + ++ + + +N C+ C + CWG G + C +
Sbjct: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
Query: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQC------AAGCTGPRESDCLVCRKFRDEATC 260
IC + C+ G R ++ S C C QC C GP +C C F+D C
Sbjct: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNC 589
Query: 261 KDTCP 265
+ CP
Sbjct: 590 VEKCP 594
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 390 bits (1003), Expect = e-109
Identities = 179/380 (47%), Positives = 250/380 (65%), Gaps = 5/380 (1%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITG 403
+DP++L++ +TV+EITG
Sbjct: 381 IEAIDPEKLNVFRTVREITG 400
Score = 68.9 bits (167), Expect = 8e-12
Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 40/245 (16%)
Query: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
Query: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
Query: 160 ESIQWRDI---VSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
+I W + ++ + + +N C+ C + CWG G + C +
Sbjct: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
Query: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQC------AAGCTGPRESDCLVCRKFRDEATC 260
IC + C+ G R ++ S C C QC C GP +C C F+D C
Sbjct: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNC 589
Query: 261 KDTCP 265
+ CP
Sbjct: 590 VEKCP 594
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 363 bits (931), Expect = e-100
Identities = 177/401 (44%), Positives = 244/401 (60%), Gaps = 14/401 (3%)
Query: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
Query: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
Query: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
Query: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
Query: 304 HGSCVRACGADSYEM-EEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
Query: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
I G L LP +F GD ++T PL P++L + +T++EITG
Sbjct: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITG 408
Score = 84.7 bits (208), Expect = 1e-16
Identities = 57/246 (23%), Positives = 101/246 (41%), Gaps = 43/246 (17%)
Query: 55 FNNCEVVLGNLEITYVQRNYD--------------LSFLKTIQEVAGYVLIAL---NTVE 97
F C+ + G+L ++ ++D L +T++E+ GY+ I+ + +
Sbjct: 364 FAGCKKIFGSL--AFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPD 421
Query: 98 RIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALC 157
+NLQ+IRG + + +Y+L + G+ L +R+L+E+ G +N LC
Sbjct: 422 LSVFQNLQVIRGRILHNGAYSLTLQG------LGISWLGLRSLRELGSGLALIHHNTHLC 475
Query: 158 NVESIQWRDIVSSD---FLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
V ++ W + + L + +G C C G CWG G C ++ +
Sbjct: 476 FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFL 535
Query: 215 CAQQCSGRCR--------GKSPSDC--CHNQC-----AAGCTGPRESDCLVCRKFRDEAT 259
Q+C CR + C CH +C + C GP C+ C ++D
Sbjct: 536 RGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPF 595
Query: 260 CKDTCP 265
C CP
Sbjct: 596 CVARCP 601
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 352 bits (903), Expect = 3e-97
Identities = 167/394 (42%), Positives = 241/394 (61%), Gaps = 8/394 (2%)
Query: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
Query: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
Query: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
Query: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
Query: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
Query: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
AC D E++++G++ C+ C G C K C G G G +++++NI F NCT I G+L
Sbjct: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSG--SRFQTVDSSNIDGFVNCTKILGNL 361
Query: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
L GD + P LDP++L++ +TV+EITG
Sbjct: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITG 395
Score = 88.6 bits (218), Expect = 9e-18
Identities = 73/282 (25%), Positives = 106/282 (37%), Gaps = 51/282 (18%)
Query: 18 LCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD-- 75
LCP K C+GT + F+ S F NC +LGNL+ N D
Sbjct: 326 LCP--------KACEGTGSG----SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPW 373
Query: 76 ----------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVL 122
L+ +T++E+ GY+ I + NL I G Y ++L ++
Sbjct: 374 HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIM 433
Query: 123 SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN 182
N + G R+L+EI G + S N LC S+ W ++ + +
Sbjct: 434 KNLNVTSLGF-----RSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNR 488
Query: 183 HLGSC----QKCDPSCPNGSCWGAGEENCQKLTKI----ICAQQC---SGRCRG-KSPSD 230
C + CDP C +G CWG G C +C C +G R ++
Sbjct: 489 PRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAE 548
Query: 231 C--CHNQC-----AAGCTGPRESDCLVCRKFRDEATCKDTCP 265
C CH +C A C G C C FRD C +CP
Sbjct: 549 CFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCP 590
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 351 bits (900), Expect = 8e-97
Identities = 165/370 (44%), Positives = 230/370 (62%), Gaps = 12/370 (3%)
Query: 45 EDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENL 104
E H L+ ++ C+VV GNLE+TY+ N LSFL+ IQEV GYVLIA N V ++PL+ L
Sbjct: 10 ETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRL 69
Query: 105 QIIRGNMYYENSYALAVLSNYD----------ANKTGLKELPMRNLQEILHGAVRFSNNP 154
+I+RG +E++YALAVL N D A+ GL+EL +R+L EIL G V NP
Sbjct: 70 RIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNP 129
Query: 155 ALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
LC ++I W+DI + +++ N +C C P C CWG E+CQ LT+ +
Sbjct: 130 QLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTV 189
Query: 215 CAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTT 274
CA C+ RC+G P+DCCH QCAAGCTGP+ SDCL C F C+ CP L+ YN T
Sbjct: 190 CAGGCA-RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDT 248
Query: 275 YQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEM-EEDGVRKCKKCEGPC 333
++ NPEG+Y+FGA+CV CP NY+ TD GSC C + E+ EDG ++C+KC PC
Sbjct: 249 FESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPC 308
Query: 334 RKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELD 393
+VC G+G+ ++ ++ + NI+ F C I G L LP +F GD ++T PL P++L
Sbjct: 309 ARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQ 368
Query: 394 ILKTVKEITG 403
+ +T++EITG
Sbjct: 369 VFETLEEITG 378
Score = 84.7 bits (208), Expect = 1e-16
Identities = 57/246 (23%), Positives = 101/246 (41%), Gaps = 43/246 (17%)
Query: 55 FNNCEVVLGNLEITYVQRNYD--------------LSFLKTIQEVAGYVLIAL---NTVE 97
F C+ + G+L ++ ++D L +T++E+ GY+ I+ + +
Sbjct: 334 FAGCKKIFGSL--AFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPD 391
Query: 98 RIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALC 157
+NLQ+IRG + + +Y+L + G+ L +R+L+E+ G +N LC
Sbjct: 392 LSVFQNLQVIRGRILHNGAYSLTLQG------LGISWLGLRSLRELGSGLALIHHNTHLC 445
Query: 158 NVESIQWRDIVSSD---FLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
V ++ W + + L + +G C C G CWG G C ++ +
Sbjct: 446 FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFL 505
Query: 215 CAQQCSGRCR--------GKSPSDC--CHNQC-----AAGCTGPRESDCLVCRKFRDEAT 259
Q+C CR + C CH +C + C GP C+ C ++D
Sbjct: 506 RGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPF 565
Query: 260 CKDTCP 265
C CP
Sbjct: 566 CVARCP 571
>gi|119395738 insulin receptor isoform Short precursor [Homo
sapiens]
Length = 1370
Score = 115 bits (288), Expect = 7e-26
Identities = 121/408 (29%), Positives = 172/408 (42%), Gaps = 76/408 (18%)
Query: 1 MRPSGTAGAA----LLALLAALCPASRALEEKKVCQGTS--NKLTQLGTFEDHFLSLQRM 54
M G GAA L+A+ A L A+ L +VC G N LT+L E
Sbjct: 1 MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELE--------- 51
Query: 55 FNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIP--LENLQII 107
NC V+ G+L+I + + DLSF K I +L + +E + NL +I
Sbjct: 52 --NCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVI 109
Query: 108 RGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDI 167
RG+ + N YAL + LKEL + NL I G+VR N LC + +I W I
Sbjct: 110 RGSRLFFN-YALVIFE-----MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI 163
Query: 168 VSS--DFLSNMSMDFQNHLG----SCQKCDPSCP----NGS----CWGAGEENCQKLTKI 213
+ S D ++ D G K +CP NG CW +CQK+
Sbjct: 164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW--THSHCQKVCPT 221
Query: 214 ICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYNP 272
IC S C + CCH++C C+ P + + C+ CR F + C +TCPP P
Sbjct: 222 ICK---SHGCTAEGL--CCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPP-----P 271
Query: 273 TTYQMD---VNPEGKYSFGATCVKKCPR------NYVVTDHGSCVRACGADSYEMEEDGV 323
+ D VN +SF KC + V + C+ C Y M +
Sbjct: 272 YYHFQDWRCVN----FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPEC-PSGYTMNSSNL 326
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHI 371
C C GPC KVC+ + + DS+ T+ + + CT I+G L I
Sbjct: 327 -LCTPCLGPCPKVCHLLEGEKTIDSV----TSAQELRGCTVINGSLII 369
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 115 bits (288), Expect = 7e-26
Identities = 121/408 (29%), Positives = 172/408 (42%), Gaps = 76/408 (18%)
Query: 1 MRPSGTAGAA----LLALLAALCPASRALEEKKVCQGTS--NKLTQLGTFEDHFLSLQRM 54
M G GAA L+A+ A L A+ L +VC G N LT+L E
Sbjct: 1 MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELE--------- 51
Query: 55 FNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIP--LENLQII 107
NC V+ G+L+I + + DLSF K I +L + +E + NL +I
Sbjct: 52 --NCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVI 109
Query: 108 RGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDI 167
RG+ + N YAL + LKEL + NL I G+VR N LC + +I W I
Sbjct: 110 RGSRLFFN-YALVIFE-----MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI 163
Query: 168 VSS--DFLSNMSMDFQNHLG----SCQKCDPSCP----NGS----CWGAGEENCQKLTKI 213
+ S D ++ D G K +CP NG CW +CQK+
Sbjct: 164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW--THSHCQKVCPT 221
Query: 214 ICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYNP 272
IC S C + CCH++C C+ P + + C+ CR F + C +TCPP P
Sbjct: 222 ICK---SHGCTAEGL--CCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPP-----P 271
Query: 273 TTYQMD---VNPEGKYSFGATCVKKCPR------NYVVTDHGSCVRACGADSYEMEEDGV 323
+ D VN +SF KC + V + C+ C Y M +
Sbjct: 272 YYHFQDWRCVN----FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPEC-PSGYTMNSSNL 326
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHI 371
C C GPC KVC+ + + DS+ T+ + + CT I+G L I
Sbjct: 327 -LCTPCLGPCPKVCHLLEGEKTIDSV----TSAQELRGCTVINGSLII 369
>gi|54792102 erbB-3 isoform s precursor [Homo sapiens]
Length = 183
Score = 106 bits (265), Expect = 3e-23
Identities = 53/131 (40%), Positives = 81/131 (61%), Gaps = 1/131 (0%)
Query: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
Query: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
Query: 131 -GLKELPMRNL 140
L++L + L
Sbjct: 129 HALRQLRLTQL 139
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 93.6 bits (231), Expect = 3e-19
Identities = 89/351 (25%), Positives = 139/351 (39%), Gaps = 67/351 (19%)
Query: 53 RMFNNCEVVLGNLEITYVQ-----RNYDLSFLKTIQEVAGYVLIALNTVERIP--LENLQ 105
+ NC V+ G L I + R+Y L I E +L + +E + NL
Sbjct: 47 KRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYL--LLFRVAGLESLGDLFPNLT 104
Query: 106 IIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWR 165
+IRG + N YAL + T LK++ + NL+ I GA+R N LC + ++ W
Sbjct: 105 VIRGWKLFYN-YALVIFE-----MTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWS 158
Query: 166 ---DIVSSDFLSNMSMDFQNHLGSCQKCDPSCP------------------NGSCWGAGE 204
D VS++++ ++C CP N CW
Sbjct: 159 LILDAVSNNYIVGNKPP--------KECGDLCPGTMEEKPMCEKTTINNEYNYRCWTT-- 208
Query: 205 ENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP-RESDCLVCRKFRDEATCKDT 263
CQK+ C C R ++ ++CCH +C C+ P ++ C+ CR + C
Sbjct: 209 NRCQKM----CPSTCGKRACTEN-NECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPA 263
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCV---KKCPRNYVVTDHGSCVRACGADSYEMEE 320
CP P TY+ + F A + +V+ D G C++ C +
Sbjct: 264 CP------PNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD-GECMQECPSGFIRNGS 316
Query: 321 DGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHI 371
+ C CEGPC KVC E K + T+ + + CT G+L I
Sbjct: 317 QSM-YCIPCEGPCPKVCE----EEKKTKTIDSVTSAQMLQGCTIFKGNLLI 362
Score = 30.0 bits (66), Expect = 3.9
Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 25/120 (20%)
Query: 51 LQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGN 110
L+ EVV G ++I + LSFLK + ++I G
Sbjct: 374 LENFMGLIEVVTGYVKIRHSHALVSLSFLKNL----------------------RLILGE 411
Query: 111 MYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSS 170
E +Y+ VL N N L + RNL I G + F+ NP LC E + ++ +
Sbjct: 412 EQLEGNYSFYVLDN--QNLQQLWDWDHRNL-TIKAGKMYFAFNPKLCVSEIYRMEEVTGT 468
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 82.4 bits (202), Expect = 7e-16
Identities = 97/380 (25%), Positives = 148/380 (38%), Gaps = 71/380 (18%)
Query: 53 RMFNNCEVVLGNLEITYV-----QRNYDLSFLKTIQEVAGYVLIALNTVERIP--LENLQ 105
R NC VV G+L+I + + LSF + Q +L + +E + NL
Sbjct: 43 RQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLA 102
Query: 106 IIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWR 165
+IRG + YAL + L+++ + L +L GAVR N LC++ +I W
Sbjct: 103 VIRGTRLFLG-YALVIFE-----MPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWG 156
Query: 166 DIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLT-------KIICAQQ 218
+ + +++ N LG ++C CP GA E C K T + +
Sbjct: 157 LLQPAPGANHI---VGNKLG--EECADVCP--GVLGAAGEPCAKTTFSGHTDYRCWTSSH 209
Query: 219 CSGRC------RGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYN 271
C C + +CCH +C GC+ P + C+ CR + C CP
Sbjct: 210 CQRVCPCPHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACP------ 263
Query: 272 PTTYQMDVNPEGKYSFGATCVKKCPRNYVV--------TDHGSCVRACGADSYEMEEDGV 323
P TYQ + S+ ++C + V GSC+ C + +
Sbjct: 264 PGTYQYE-------SWRCVTAERCASLHSVPGRASTFGIHQGSCLAQC-PSGFTRNSSSI 315
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
C KCEG C K C +G K SI A + CT + G L + +
Sbjct: 316 -FCHKCEGLCPKECK-VGT---KTIDSIQAA--QDLVGCTHVEGSLIL--------NLRQ 360
Query: 384 TPPLDPQELDILKTVKEITG 403
L+PQ L V+ ITG
Sbjct: 361 GYNLEPQLQHSLGLVETITG 380
Score = 35.4 bits (80), Expect = 0.093
Identities = 36/152 (23%), Positives = 65/152 (42%), Gaps = 15/152 (9%)
Query: 17 ALCPASRALEEKKV----CQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQR 72
A CP+ + C+G K ++GT + + C V G+L I +++
Sbjct: 302 AQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSL-ILNLRQ 360
Query: 73 NYDLS-----FLKTIQEVAGYVLI--ALNTVERIPLENLQIIRGNMYYENSYALAVLSNY 125
Y+L L ++ + G++ I + V +NL++IRG+ + +Y L VL N
Sbjct: 361 GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ 420
Query: 126 DANKTGLKELPMRNLQEILHGAVRFSNNPALC 157
+ + G + G + F+ NP LC
Sbjct: 421 NLQQLGSWVAAGLTIPV---GKIYFAFNPRLC 449
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 54.7 bits (130), Expect = 1e-07
Identities = 54/202 (26%), Positives = 74/202 (36%), Gaps = 56/202 (27%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQ----CSGRCRGKSPSDCCHNQCAAGCTG 242
C+KC P+C SC+G+ + C + C C S D N C C+
Sbjct: 686 CRKCAPNCE--SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRK-CS- 741
Query: 243 PRESDCLVCRKFRDEATCKD-----------TCPPLMLYNPTTYQMDVNPEGKYSFGATC 291
+C C +F + C+D +C +N D P + F ATC
Sbjct: 742 ---ENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNG----QDCQP--CHRFCATC 792
Query: 292 VK-------KCPRNYVVTDHGSCVRACGADSY--EMEEDGVRKCKKCEGPCRKVCNGIGI 342
C Y + D G CV++C Y E+G + CKKC+ C CNG G
Sbjct: 793 AGAGADGCINCTEGYFMED-GRCVQSCSISYYFDHSSENGYKSCKKCDISC-LTCNGPG- 849
Query: 343 GEFKDSLSINATNIKHFKNCTS 364
FKNCTS
Sbjct: 850 ----------------FKNCTS 855
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 52.8 bits (125), Expect = 6e-07
Identities = 55/200 (27%), Positives = 76/200 (38%), Gaps = 27/200 (13%)
Query: 159 VESIQWRDIVSSDFLSNMSMDFQ-NHLGSCQKCDPSCPNGSCWGAGEENCQKL--TKIIC 215
VE + I S + L+ F G C+ C SC C G NC + ++
Sbjct: 682 VEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFR--CAGKSPHNCTDCGPSHVLL 739
Query: 216 AQQCSGRCRG---KSPSDC--CHNQCAAGCTGPRESDCLVCRKF--RDEATCKDTCPPLM 268
QC +C C CH C C GP ESDC+ C C+ +C
Sbjct: 740 DGQCLSQCPDGYFHQEGSCTECHPTCRQ-CHGPLESDCISCYPHISLTNGNCRTSCREEQ 798
Query: 269 LYNPTTYQMDVN------PEGKYSFGATCVKKCPRNYVVT-DHGSCVRACGADSYEMEED 321
N Y D + ++ G+ C++ +Y++ DH CV C + Y E
Sbjct: 799 FLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDH--CVPDCPSGYY--AER 854
Query: 322 GVRKCKKCEGPCRKVCNGIG 341
G CKKC CR C G G
Sbjct: 855 GA--CKKCHSSCR-TCQGRG 871
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/174 (26%), Positives = 61/174 (35%), Gaps = 54/174 (31%)
Query: 174 SNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCRGKSPSDC 231
S+ F N G+C CD SC SC G C T+ ++ +C C G +D
Sbjct: 545 SSCGKGFYNRQGTCSACDQSC--DSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYYADA 601
Query: 232 ------CHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKY 285
CHN CA+ C+GP S C C PP L
Sbjct: 602 TGRCKVCHNSCAS-CSGPTPSHCTAC------------SPPKALRQ-------------- 634
Query: 286 SFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
C+ +C + +DHG C +AC + C C GP C G
Sbjct: 635 ---GHCLPRCGEGF-YSDHGVC-KACHS-----------SCLACMGPAPSHCTG 672
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/180 (23%), Positives = 58/180 (32%), Gaps = 50/180 (27%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC-----RGKSPSDCCHNQCAAGCT 241
C C P C +C E + + ++ QC C + + CH CA GC
Sbjct: 465 CLACQPQC--STCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCA-GCW 521
Query: 242 GPRESDCLVCRK------------------FRDEATCK------DTCPPLMLYNPTTYQM 277
GP E CL CR + + TC D+C P T +
Sbjct: 522 GPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEK 581
Query: 278 DVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVC 337
V +GK C+ +CP Y G C + C C C GP C
Sbjct: 582 TVLHDGK------CMSECPGGYYADATGRC-KVCH-----------NSCASCSGPTPSHC 623
Score = 43.9 bits (102), Expect = 3e-04
Identities = 47/182 (25%), Positives = 63/182 (34%), Gaps = 37/182 (20%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT--KIICAQQCSGRCRGKSPSD-----CCHNQCA 237
G C+ C SC SC G +C + K + C RC SD CH+ C
Sbjct: 603 GRCKVCHNSC--ASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCL 660
Query: 238 AGCTGPRESDCLVCRKFRD-------------EATCKDTCPPLMLYNPT-----TYQMDV 279
A C GP S C C+K + C C T +Q
Sbjct: 661 A-CMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCF 719
Query: 280 NPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRK----CKKCEGPCRK 335
GK T C ++V+ D G C+ C D Y +E + C++C GP
Sbjct: 720 RCAGKSPHNCT---DCGPSHVLLD-GQCLSQC-PDGYFHQEGSCTECHPTCRQCHGPLES 774
Query: 336 VC 337
C
Sbjct: 775 DC 776
Score = 42.4 bits (98), Expect = 8e-04
Identities = 39/159 (24%), Positives = 61/159 (38%), Gaps = 46/159 (28%)
Query: 182 NHLGSCQKCDPSCPNGSCWG-AGEENCQKLTKIICAQQCSGR-CRGKSPSDCCHNQC--- 236
NH+ CQ C+ C GSC A +C+ K++ +C C + D N C
Sbjct: 903 NHV--CQPCNTHC--GSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC 958
Query: 237 ---AAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
+ C+GP ++DCL C +G CV+
Sbjct: 959 DWSCSACSGPLKTDCLQCM-----------------------------DGYVLQDGACVE 989
Query: 294 KCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGP 332
+C ++ D G C DSY ++ G +C +C+GP
Sbjct: 990 QCLSSFY-QDSG----LCKCDSYCLQCQGPHECTRCKGP 1023
Score = 31.2 bits (69), Expect = 1.8
Identities = 51/190 (26%), Positives = 65/190 (34%), Gaps = 35/190 (18%)
Query: 190 CDPS-CPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCH-NQCAAGCTGPRESD 247
C P+ C N C E Q I A QC C ++P C H + T S
Sbjct: 58 CKPAVCRNPQCAFEKGEVLQ-----IAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSP 112
Query: 248 CLVCRKFRDEATC-KDTCPPLM--------------------LYNPTTYQMDVNPEGKYS 286
C VC E C CPPL L P +Y+ V +G+
Sbjct: 113 CSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDW 172
Query: 287 FGATCVKKCPRNYVVTDHGSCVRA-CGADSYEMEEDGVRKCKKCEGPC-RKVCNGIG-IG 343
+ C K RN V C A C +E VR KC C + C+ G +
Sbjct: 173 RLSRCAKCLCRNGV----AQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVY 228
Query: 344 EFKDSLSINA 353
E + S NA
Sbjct: 229 EHGEQWSENA 238
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/174 (26%), Positives = 67/174 (38%), Gaps = 27/174 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCEG 282
Score = 38.5 bits (88), Expect = 0.011
Identities = 41/206 (19%), Positives = 61/206 (29%), Gaps = 63/206 (30%)
Query: 190 CDPSCPNG----------------SCWGAGEENCQKLTKI-------ICAQQC-SGRCRG 225
C SCP G C G ++C+ + +C ++C +G
Sbjct: 346 CHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYE 405
Query: 226 KSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYN------- 271
K +C CH C T C C+K R + C P ++
Sbjct: 406 KQTKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCK 462
Query: 272 -----------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEE 320
P Q P TCVK CP Y + + C +
Sbjct: 463 PCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHS------- 515
Query: 321 DGVRKCKKCEGPCRKVCNGIGIGEFK 346
C+ CEG + C+ G F+
Sbjct: 516 ----SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 34.3 bits (77), Expect = 0.21
Identities = 41/180 (22%), Positives = 65/180 (36%), Gaps = 50/180 (27%)
Query: 189 KCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT---GPRE 245
+C CP GS A + C++ C+ C C G + + CH+ C G G +
Sbjct: 254 RCYSKCPEGSY--AEDGICER-----CSSPCR-TCEGNATN--CHS-CEGGHVLHHGVCQ 302
Query: 246 SDCL---------------VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGAT 290
+C +C+ E TCK+ P L++ +Q P G Y+
Sbjct: 303 ENCPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFLHDDMCHQS--CPRGFYADSHH 360
Query: 291 CV-----------------KKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
CV + C + V G C+ C A +Y E ++C+ C C
Sbjct: 361 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTY--YEKQTKECRDCHKSC 418
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 18/78 (23%)
Query: 281 PEGKYSFGATCVKKCPRNYVVTDH--------------GSCVRACGADSYEMEEDGVRKC 326
PE YS C K C N D GSCVR CG Y +E G +C
Sbjct: 65 PEKTYSEAVEC-KACDSNCSSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMG--EC 121
Query: 327 KKCEGPCRKVCNGIGIGE 344
+ C C + C G G E
Sbjct: 122 ESCHRAC-ETCTGPGHDE 138
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/174 (26%), Positives = 67/174 (38%), Gaps = 27/174 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCEG 282
Score = 42.7 bits (99), Expect = 6e-04
Identities = 44/179 (24%), Positives = 63/179 (35%), Gaps = 47/179 (26%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKII---CAQQCSGRCRG-KSPSDC--CHNQCAAGC 240
C+ CD +C GSC G C++ ++ C ++C G + +C CH C C
Sbjct: 75 CKACDSNC--GSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACET-C 131
Query: 241 TGPRESDCLVCRK-------------------------FRDEATCKDTCPPLMLYNPTTY 275
TGP +C C++ R C +C N +
Sbjct: 132 TGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTC---NGSAT 188
Query: 276 QMDVNPEGKYSFGATCVKKCPR-NYVVTDHGS---CVRACGADSYEMEEDGVRKCKKCE 330
P+G Y CV CP+ + GS C AC S G CKKC+
Sbjct: 189 LCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICS------GADLCKKCQ 241
Score = 38.9 bits (89), Expect = 0.008
Identities = 44/224 (19%), Positives = 67/224 (29%), Gaps = 74/224 (33%)
Query: 183 HLGSCQKCDP-----------SCPNG----------------SCWGAGEENCQKLTKI-- 213
H +C++C P SCP G C G ++C+ +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 214 -----ICAQQC-SGRCRGKSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATC 260
+C ++C +G K +C CH C T C C+K R
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMA 444
Query: 261 KDTCPPLMLYN------------------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVT 302
+ C P ++ P Q P TCVK CP Y
Sbjct: 445 NEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYAD 504
Query: 303 DHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK 346
+ + C + C+ CEG + C+ G F+
Sbjct: 505 EDSNRCAHCHS-----------SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 35.4 bits (80), Expect = 0.093
Identities = 41/180 (22%), Positives = 66/180 (36%), Gaps = 50/180 (27%)
Query: 189 KCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT---GPRE 245
+C CP GS A + C++ C+ C C G + + CH+ C G G +
Sbjct: 254 RCYSKCPEGSY--AEDGICER-----CSSPCR-TCEGNATN--CHS-CEGGHVLHHGVCQ 302
Query: 246 SDCL---------------VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGAT 290
+C +C+ E TCK+ P L++ +Q P G Y+
Sbjct: 303 ENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQS--CPRGFYADSRH 360
Query: 291 CV-----------------KKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
CV + C + V G C+ C A +Y +E ++C+ C C
Sbjct: 361 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKE--TKECRDCHKSC 418
Score = 33.1 bits (74), Expect = 0.46
Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 18/78 (23%)
Query: 281 PEGKYSFGATCVKKCPRNYVVTDH--------------GSCVRACGADSYEMEEDGVRKC 326
PE YS C K C N D GSCVR CG Y +E G +C
Sbjct: 65 PEKTYSEAVEC-KACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMG--EC 121
Query: 327 KKCEGPCRKVCNGIGIGE 344
+ C C + C G G E
Sbjct: 122 ESCHRAC-ETCTGPGHDE 138
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/174 (26%), Positives = 67/174 (38%), Gaps = 27/174 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCEG 282
Score = 42.7 bits (99), Expect = 6e-04
Identities = 44/179 (24%), Positives = 63/179 (35%), Gaps = 47/179 (26%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKII---CAQQCSGRCRG-KSPSDC--CHNQCAAGC 240
C+ CD +C GSC G C++ ++ C ++C G + +C CH C C
Sbjct: 75 CKACDSNC--GSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACET-C 131
Query: 241 TGPRESDCLVCRK-------------------------FRDEATCKDTCPPLMLYNPTTY 275
TGP +C C++ R C +C N +
Sbjct: 132 TGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTC---NGSAT 188
Query: 276 QMDVNPEGKYSFGATCVKKCPR-NYVVTDHGS---CVRACGADSYEMEEDGVRKCKKCE 330
P+G Y CV CP+ + GS C AC S G CKKC+
Sbjct: 189 LCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICS------GADLCKKCQ 241
Score = 38.9 bits (89), Expect = 0.008
Identities = 44/224 (19%), Positives = 67/224 (29%), Gaps = 74/224 (33%)
Query: 183 HLGSCQKCDP-----------SCPNG----------------SCWGAGEENCQKLTKI-- 213
H +C++C P SCP G C G ++C+ +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 214 -----ICAQQC-SGRCRGKSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATC 260
+C ++C +G K +C CH C T C C+K R
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMA 444
Query: 261 KDTCPPLMLYN------------------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVT 302
+ C P ++ P Q P TCVK CP Y
Sbjct: 445 NEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYAD 504
Query: 303 DHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK 346
+ + C + C+ CEG + C+ G F+
Sbjct: 505 EDSNRCAHCHS-----------SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 35.4 bits (80), Expect = 0.093
Identities = 41/180 (22%), Positives = 66/180 (36%), Gaps = 50/180 (27%)
Query: 189 KCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT---GPRE 245
+C CP GS A + C++ C+ C C G + + CH+ C G G +
Sbjct: 254 RCYSKCPEGSY--AEDGICER-----CSSPCR-TCEGNATN--CHS-CEGGHVLHHGVCQ 302
Query: 246 SDCL---------------VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGAT 290
+C +C+ E TCK+ P L++ +Q P G Y+
Sbjct: 303 ENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQS--CPRGFYADSRH 360
Query: 291 CV-----------------KKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
CV + C + V G C+ C A +Y +E ++C+ C C
Sbjct: 361 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKE--TKECRDCHKSC 418
Score = 33.5 bits (75), Expect = 0.35
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 260 CKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKK----CPRNYVVTDHGSCVRACGADS 315
C TCP TY +V + S +C + C + + GSCVR CG
Sbjct: 60 CYKTCPE------KTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLG-GSCVRKCGPGF 112
Query: 316 YEMEEDGVRKCKKCEGPCRKVCNGIGIGE 344
Y +E G +C+ C C + C G G E
Sbjct: 113 YGDQEMG--ECESCHRAC-ETCTGPGHDE 138
>gi|28626521 zinc finger, NFX1-type containing 1 [Homo sapiens]
Length = 1918
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/128 (27%), Positives = 49/128 (38%), Gaps = 18/128 (14%)
Query: 185 GSCQKCDPSCPNGSCWGAGE----ENCQKLTK--IICAQQCSGRCRGKSP-------SDC 231
G+ C CP GSC E E CQ+ K +IC+ +C C G+ P + C
Sbjct: 1436 GTILDCGHPCP-GSCHSCFEGRFHERCQQPCKRLLICSHKCQEPCIGECPPCQRTCQNRC 1494
Query: 232 CHNQC----AAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSF 287
H+QC C+ E C+ ++ C + C Y P T +
Sbjct: 1495 VHSQCKKKCGELCSPCVEPCVWRCQHYQCTKLCSEPCNRPPCYVPCTKLLVCGHPCIGLC 1554
Query: 288 GATCVKKC 295
G C KKC
Sbjct: 1555 GEPCPKKC 1562
Score = 30.0 bits (66), Expect = 3.9
Identities = 16/60 (26%), Positives = 24/60 (40%), Gaps = 9/60 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
+G C C +C N ++ C +L C + C RC+ H QC C+ P
Sbjct: 1480 IGECPPCQRTCQNRCVHSQCKKKCGELCS-PCVEPCVWRCQ--------HYQCTKLCSEP 1530
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
Score = 36.2 bits (82), Expect = 0.054
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
Score = 30.4 bits (67), Expect = 3.0
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 834 ECHHTCGT-CVGPGREECIHCAK 855
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
Score = 36.2 bits (82), Expect = 0.054
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
Score = 30.4 bits (67), Expect = 3.0
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 847 ECHHTCGT-CVGPGREECIHCAK 868
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
Score = 36.2 bits (82), Expect = 0.054
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
Score = 30.4 bits (67), Expect = 3.0
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 847 ECHHTCGT-CVGPGREECIHCAK 868
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
Score = 36.2 bits (82), Expect = 0.054
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
Score = 30.4 bits (67), Expect = 3.0
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 834 ECHHTCGT-CVGPGREECIHCAK 855
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 37.4 bits (85), Expect = 0.024
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 23/131 (17%)
Query: 206 NCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP 265
NC + I+ QC CRG HN CA GP+ + C+ + +ATC+
Sbjct: 372 NCSEKDHILPENQCCRVCRG-------HNFCA---EGPKCGENSECKNWNTKATCECKSG 421
Query: 266 PLMLYNPTTYQMDVNP-EGKYSF---GATCVK-------KCPRNYVVTDHGSCVR--ACG 312
+ + + Y D++ K + CV C Y+ D SC CG
Sbjct: 422 YISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
Query: 313 ADSYEMEEDGV 323
+ + +E+ +
Sbjct: 482 SGQHNCDENAI 492
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 37.4 bits (85), Expect = 0.024
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 23/131 (17%)
Query: 206 NCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP 265
NC + I+ QC CRG HN CA GP+ + C+ + +ATC+
Sbjct: 372 NCSEKDHILPENQCCRVCRG-------HNFCA---EGPKCGENSECKNWNTKATCECKSG 421
Query: 266 PLMLYNPTTYQMDVNP-EGKYSF---GATCVK-------KCPRNYVVTDHGSCVR--ACG 312
+ + + Y D++ K + CV C Y+ D SC CG
Sbjct: 422 YISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
Query: 313 ADSYEMEEDGV 323
+ + +E+ +
Sbjct: 482 SGQHNCDENAI 492
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 37.4 bits (85), Expect = 0.024
Identities = 37/148 (25%), Positives = 55/148 (37%), Gaps = 28/148 (18%)
Query: 182 NHLGSCQKCDPSCPNGSCWGA-----GEENC-QKLTKIICAQQCSGRCRGKSPSDCCHNQ 235
N +CQ +CPN C G+++C ++ C C+ S C
Sbjct: 1144 NSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTA-----SQFKCASGD 1198
Query: 236 CAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYN------------PTTYQMDVNPE- 282
G T R C DEA C T PP M ++ P ++ D +P+
Sbjct: 1199 KCIGVTN-RCDGVFDCSDNSDEAGCP-TRPPGMCHSDEFQCQEDGICIPNFWECDGHPDC 1256
Query: 283 --GKYSFGATCVKKCPRNYVVTDHGSCV 308
G A K CP +Y D+G+C+
Sbjct: 1257 LYGSDEHNACVPKTCPSSYFHCDNGNCI 1284
Score = 31.2 bits (69), Expect = 1.8
Identities = 46/195 (23%), Positives = 62/195 (31%), Gaps = 52/195 (26%)
Query: 186 SCQKCDPSCPNGSCW--------------GAGEENCQKLT--KIIC--------AQQCSG 221
+C +C NG C GA E +CQ T ++ C +Q+C
Sbjct: 107 TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDW 166
Query: 222 RCRGKSPSD-------CCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTT 274
+ + SD C HN+ + G G VC D C+D PT
Sbjct: 167 KVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDND---CQDGSDEHACNYPTC 222
Query: 275 YQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC- 333
G Y F + +N+V C D E V KC E C
Sbjct: 223 --------GGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCP 274
Query: 334 --------RKVCNGI 340
KVC+GI
Sbjct: 275 ESGRCISIYKVCDGI 289
>gi|33598931 scavenger receptor class F, member 1 isoform 3
precursor [Homo sapiens]
Length = 569
Score = 37.0 bits (84), Expect = 0.032
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 10/118 (8%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT-KIICAQQCSGRCRGKS-PSDCCHNQ-CAAGCT 241
GSC+ C+P C ++ C T C QQC G++ D H Q C G
Sbjct: 279 GSCESCEPGWNGTQC----QQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWL 334
Query: 242 GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNY 299
GPR D F ++ C TCP + + T D Y +G +C CP +
Sbjct: 335 GPRCEDPCPTGTFGED--CGSTCPTCVQGSCDTVTGDCVCSAGY-WGPSCNASCPAGF 389
Score = 32.3 bits (72), Expect = 0.79
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 13/56 (23%)
Query: 287 FGATCVKKCPRNYVVTD---------HGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
FGA C +CP Y D HG C A GA + + G R CE PC
Sbjct: 82 FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGAR----CEFPC 133
Score = 29.6 bits (65), Expect = 5.1
Identities = 27/110 (24%), Positives = 38/110 (34%), Gaps = 25/110 (22%)
Query: 185 GSCQKCDPS---------CPNG--------SCWGAGEENCQKLT-KIICAQQCSG-RCRG 225
G CQ+CDP CP G +C + +C +T +C+ G C
Sbjct: 324 GHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNA 383
Query: 226 KSPSDCCHNQCAAGCTGPR------ESDCLVCRKFRDEATCKDTCPPLML 269
P+ N C+ C P C RD A + PL+L
Sbjct: 384 SCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLL 433
>gi|33598929 scavenger receptor class F, member 1 isoform 1
precursor [Homo sapiens]
Length = 830
Score = 37.0 bits (84), Expect = 0.032
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 10/118 (8%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT-KIICAQQCSGRCRGKS-PSDCCHNQ-CAAGCT 241
GSC+ C+P C ++ C T C QQC G++ D H Q C G
Sbjct: 279 GSCESCEPGWNGTQC----QQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWL 334
Query: 242 GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNY 299
GPR D F ++ C TCP + + T D Y +G +C CP +
Sbjct: 335 GPRCEDPCPTGTFGED--CGSTCPTCVQGSCDTVTGDCVCSAGY-WGPSCNASCPAGF 389
Score = 32.3 bits (72), Expect = 0.79
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 13/56 (23%)
Query: 287 FGATCVKKCPRNYVVTD---------HGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
FGA C +CP Y D HG C A GA + + G R CE PC
Sbjct: 82 FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGAR----CEFPC 133
Score = 29.6 bits (65), Expect = 5.1
Identities = 27/110 (24%), Positives = 38/110 (34%), Gaps = 25/110 (22%)
Query: 185 GSCQKCDPS---------CPNG--------SCWGAGEENCQKLT-KIICAQQCSG-RCRG 225
G CQ+CDP CP G +C + +C +T +C+ G C
Sbjct: 324 GHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNA 383
Query: 226 KSPSDCCHNQCAAGCTGPR------ESDCLVCRKFRDEATCKDTCPPLML 269
P+ N C+ C P C RD A + PL+L
Sbjct: 384 SCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLL 433
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 37.0 bits (84), Expect = 0.032
Identities = 37/140 (26%), Positives = 52/140 (37%), Gaps = 24/140 (17%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLT---KIICAQQCSGRCRGKSPSDCCHNQCAAGCTG 242
+C+K + +C + C G +C ++ + C SG +C N CAAG T
Sbjct: 343 NCEKAEHACTSNPCANGG--SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTC 400
Query: 243 PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNP-EGKYSFGATCVKKCPRNYVV 301
+ D C CP + T Q+DVN G+ G TC K Y
Sbjct: 401 VDQVDGFEC-----------ICPEQWV--GATCQLDVNDCRGQCQHGGTC-KDLVNGYQC 446
Query: 302 TDHGSCVRACGADSYEMEED 321
C R G E+E D
Sbjct: 447 V----CPRGFGGRHCELERD 462
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,804,770
Number of Sequences: 37866
Number of extensions: 809425
Number of successful extensions: 2253
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 116
Number of HSP's that attempted gapping in prelim test: 1919
Number of HSP's gapped (non-prelim): 343
length of query: 405
length of database: 18,247,518
effective HSP length: 105
effective length of query: 300
effective length of database: 14,271,588
effective search space: 4281476400
effective search space used: 4281476400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.