Guide to the Human Genome
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Name: EGFR Sequence: fasta or formatted (1210aa) NCBI GI: 29725609
Description:

epidermal growth factor receptor isoform a precursor

Referenced in:

Common Drug Targets
Epidermal Growth Factor
Retroviral Oncogene Homologs

Other entries for this name:
alt prot [628aa] epidermal growth factor receptor isoform b precursor
alt prot [405aa] epidermal growth factor receptor isoform c precursor
alt prot [705aa] epidermal growth factor receptor isoform d precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.0         72           2
 C cysteine            5.0         60           2
 D aspartate           5.0         61           2
 E glutamate           6.4         77           2
 F phenylalanine       3.0         36           2
 G glycine             7.0         85           2
 H histidine           2.6         31           1
 I isoleucine          5.7         69           2
 K lysine              5.5         66           2
 L leucine             9.2        111           5
 M methionine          2.1         25           1
 N asparagine          5.5         66           2
 P proline             6.2         75           2
 Q glutamine           4.0         49           2
 R arginine            5.0         60           3
 S serine              6.9         84           2
 T threonine           5.3         64           2
 V valine              5.8         70           2
 W tryptophan          1.1         13           1
 Y tyrosine            3.0         36           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   epidermal growth factor receptor isoform a precursor... 
EGFR                  0.525   epidermal growth factor receptor isoform d precursor...
EGFR                  0.525   epidermal growth factor receptor isoform b precursor...
ERBB4                 0.498   v-erb-a erythroblastic leukemia viral oncogene homo...
ERBB4                 0.497   v-erb-a erythroblastic leukemia viral oncogene homolo...
ERBB2                 0.471   erbB-2 isoform a 
ERBB2                 0.466   erbB-2 isoform b 
ERBB3                 0.385   erbB-3 isoform 1 precursor 
EGFR                  0.330   epidermal growth factor receptor isoform c precursor...
TNK2                  0.076   tyrosine kinase, non-receptor, 2 isoform 1 
TNK2                  0.076   tyrosine kinase, non-receptor, 2 isoform 2 
EPHA2                 0.074   ephrin receptor EphA2 
EPHA3                 0.072   ephrin receptor EphA3 isoform a precursor 
PTK2                  0.072   PTK2 protein tyrosine kinase 2 isoform b 
PTK2                  0.072   PTK2 protein tyrosine kinase 2 isoform a 
SYK                   0.071   spleen tyrosine kinase isoform 2 
SYK                   0.071   spleen tyrosine kinase isoform 1 
EPHB1                 0.071   ephrin receptor EphB1 precursor 
ABL2                  0.071   arg tyrosine kinase isoform c 
ABL2                  0.071   arg tyrosine kinase isoform b 
ABL2                  0.071   arg tyrosine kinase isoform e 
ABL2                  0.071   arg tyrosine kinase isoform d 
ABL2                  0.071   arg tyrosine kinase isoform a 
EPHA1                 0.070   ephrin receptor EphA1 
EPHA5                 0.070   ephrin receptor EphA5 isoform b precursor 
RET                   0.070   ret proto-oncogene isoform c 
RET                   0.070   ret proto-oncogene isoform a 
PTK2B                 0.069   PTK2B protein tyrosine kinase 2 beta isoform a [Homo...
PTK2B                 0.069   PTK2B protein tyrosine kinase 2 beta isoform b [Homo...
PTK2B                 0.069   PTK2B protein tyrosine kinase 2 beta isoform a [Homo...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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