Guide to the Human Genome
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Search of human proteins with 40353729

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40353729 Ras and Rab interactor 3 [Homo sapiens]
         (985 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40353729 Ras and Rab interactor 3 [Homo sapiens]                  1988   0.0  
gi|18466802 Ras and Rab interactor 2 [Homo sapiens]                   323   4e-88
gi|68989256 ras inhibitor RIN1 [Homo sapiens]                         164   4e-40
gi|38348206 Ras and Rab interactor-like [Homo sapiens]                130   5e-30
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    87   8e-17
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    84   5e-16
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    83   1e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    79   3e-14
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    78   5e-14
gi|150170670 piccolo isoform 2 [Homo sapiens]                          76   1e-13
gi|150378539 piccolo isoform 1 [Homo sapiens]                          76   1e-13
gi|163965366 nascent polypeptide-associated complex alpha subuni...    75   2e-13
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   75   3e-13
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   75   3e-13
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   75   3e-13
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    75   3e-13
gi|47132519 Ras association and pleckstrin homology domains 1 is...    74   7e-13
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    73   1e-12
gi|146134388 YLP motif containing 1 [Homo sapiens]                     71   4e-12
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    70   1e-11
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   69   2e-11
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                   69   2e-11
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        69   3e-11
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       68   4e-11
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       68   4e-11
gi|116284392 mucin 2 precursor [Homo sapiens]                          68   5e-11
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    67   8e-11
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             66   1e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    66   1e-10
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    66   2e-10

>gi|40353729 Ras and Rab interactor 3 [Homo sapiens]
          Length = 985

 Score = 1988 bits (5151), Expect = 0.0
 Identities = 985/985 (100%), Positives = 985/985 (100%)

Query: 1   MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTC 60
           MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTC
Sbjct: 1   MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTC 60

Query: 61  PVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEE 120
           PVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEE
Sbjct: 61  PVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEE 120

Query: 121 KSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFW 180
           KSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFW
Sbjct: 121 KSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFW 180

Query: 181 DSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFI 240
           DSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFI
Sbjct: 181 DSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFI 240

Query: 241 EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL 300
           EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL
Sbjct: 241 EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL 300

Query: 301 PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK 360
           PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK
Sbjct: 301 PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK 360

Query: 361 PGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSD 420
           PGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSD
Sbjct: 361 PGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSD 420

Query: 421 GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN 480
           GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN
Sbjct: 421 GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN 480

Query: 481 AELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGV 540
           AELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGV
Sbjct: 481 AELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGV 540

Query: 541 SVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRK 600
           SVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRK
Sbjct: 541 SVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRK 600

Query: 601 LYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTE 660
           LYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTE
Sbjct: 601 LYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTE 660

Query: 661 LKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVIL 720
           LKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVIL
Sbjct: 661 LKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVIL 720

Query: 721 ATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGK 780
           ATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGK
Sbjct: 721 ATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGK 780

Query: 781 PYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSY 840
           PYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSY
Sbjct: 781 PYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSY 840

Query: 841 DKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADT 900
           DKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADT
Sbjct: 841 DKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADT 900

Query: 901 QAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVY 960
           QAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVY
Sbjct: 901 QAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVY 960

Query: 961 RPLDGGGGGGGGSPPCLVVREPNFL 985
           RPLDGGGGGGGGSPPCLVVREPNFL
Sbjct: 961 RPLDGGGGGGGGSPPCLVVREPNFL 985


>gi|18466802 Ras and Rab interactor 2 [Homo sapiens]
          Length = 895

 Score =  323 bits (829), Expect = 4e-88
 Identities = 207/573 (36%), Positives = 304/573 (53%), Gaps = 34/573 (5%)

Query: 414 PPQGTSDGPEDTPRESTEQGQDT--EVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLA 471
           PP    +    +PR +  + Q +  E    + H    LP T K  P+PPPR K+ +  L 
Sbjct: 311 PPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGT-KPTPIPPPRLKKQASFLE 369

Query: 472 STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAG--TQHPPAQATAHSQSSPEFKG 529
           +   A   +         LE  T G P  G  P +  G  T+ PP      S+S P   G
Sbjct: 370 AEGGAKTLSGGRPGAGPELELGTAGSPG-GAPPEAAPGDCTRAPPPS----SESRPPCHG 424

Query: 530 SLASLSDSLGVSVMATDQDSYSTS--------STEEELEQFSSPS-----------VKKK 570
               LSD + +S  ++D   +  S         T   LE +   S            KK+
Sbjct: 425 GRQRLSD-MSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKR 483

Query: 571 PSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEM 630
            S  +     +      S +F +F++  +++ +++ EL++DK +YFG LVQDY  +  E 
Sbjct: 484 SSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQEN 543

Query: 631 MARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKP 690
                SST+MLQ IR  MTQ+K+YL QS+EL   ++ +L  E++++ ++E A++KC+LKP
Sbjct: 544 KECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIE-SLIPEDQIDVVLEKAMHKCILKP 602

Query: 691 LKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMH 750
           LK  + + L   H  DGS +QLKEN  ++      +LGV    P+   +EKI  KF +M 
Sbjct: 603 LKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQ 662

Query: 751 KAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYM 810
           K YSPEKK+ +LL+ CKLIY  M   N G+ YGADDFLPVL YV+A+ ++ E+   +EYM
Sbjct: 663 KMYSPEKKVMLLLRVCKLIYTVME-NNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYM 721

Query: 811 MELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKAR 870
           MEL+DP+L  GEG YYLT+ YGAL  IK++ +    R LS E +D++ +W +RRT N+  
Sbjct: 722 MELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTI 781

Query: 871 ASRSSVQDFICVSYLEPEQ--QARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVD 928
            S    Q+++ V++ E       +TL  R     + +C  CAEKF V  P+ + LF+ VD
Sbjct: 782 PSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVD 841

Query: 929 GRCFQLADDALPHCIKGYLLRSEPKRDFHFVYR 961
               QLA+D  P  IK  L        FHFVY+
Sbjct: 842 ETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYK 874



 Score =  154 bits (389), Expect = 4e-37
 Identities = 147/467 (31%), Positives = 210/467 (44%), Gaps = 71/467 (15%)

Query: 28  EEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLV 87
           EE+ ++ C   +  + L +R  +SIL++L+ T P+WLQLSL + E A +L     G+FLV
Sbjct: 64  EEEDVKTCARDSGYDSLSNR--LSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLV 121

Query: 88  RRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSR 147
            + +  ++ VL +  P   E  A + E+ IKE      LEGS + F D+FRLIAFYC+SR
Sbjct: 122 HKSTKMQKKVLSLRLPC--EFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISR 179

Query: 148 DLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLV 207
           D+LPFTL+LP AI  A S   LE +A +GL FW S    P +   P  PP  R      V
Sbjct: 180 DVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSS----PADSKPPNLPPPHRPLSSDGV 235

Query: 208 --SSLRPT-------AHDANCACEIELSVGNDRLWFVNPIFI----EDCSSAL--PTDQP 252
             +SLR         +       E+E S  N  L F+NP+F+    +D S  L  P+ + 
Sbjct: 236 CPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRT 295

Query: 253 PLGNCPARPLPPTSDATSPTSRWAPRRPPPP-------PPVLPLQPCSPAQPPVLPALAP 305
           P  N   R   P            P RPPPP        P L       + P  +     
Sbjct: 296 PNANGTERTRSP------------PPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKH 343

Query: 306 APACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCE----RLPCPTAGLGPLRE--EAM 359
                LP + P P P        PP    Q   +  E     L     G GP  E   A 
Sbjct: 344 GNVA-LPGTKPTPIP--------PPRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAG 394

Query: 360 KPGAA---SSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQ 416
            PG A   ++P     APP  ++   P    R+R+S+ +S+   S   + E D+ S+P  
Sbjct: 395 SPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSD-MSISTSSSD-SLEFDR-SMPLF 451

Query: 417 G----TSDGPEDTPRESTEQGQDTEVKASDPHS----MPELPRTAKQ 455
           G    T+   ED   ES ++     +K+    S    +P+L ++  Q
Sbjct: 452 GYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQ 498


>gi|68989256 ras inhibitor RIN1 [Homo sapiens]
          Length = 783

 Score =  164 bits (415), Expect = 4e-40
 Identities = 143/491 (29%), Positives = 225/491 (45%), Gaps = 41/491 (8%)

Query: 463 KKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQ 522
           K R+S + +S L  P               P P P   G  P+    T+  P       +
Sbjct: 246 KVRVSTETSSPLSPPAV------------PPPPVPVLPGAVPSQ---TERLPPCQLLRRE 290

Query: 523 SSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRL 582
           SS  ++    S   SL       + D  S SS+EEE      P  +  P+      R R 
Sbjct: 291 SSVGYRVPAGS-GPSLPPMPSLQEVDCGSPSSSEEE----GVPGSRGSPATSPHLGRRRP 345

Query: 583 SFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQ 642
              S S+ F + L+  R++ +    L QD+ +  G LVQD     L    R     + LQ
Sbjct: 346 LLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQD-----LLTQVRAGPEPQELQ 400

Query: 643 EIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQI 702
            IR  +++ ++ L      + L+ P     + LE ++E +L+  VLKPL+  + + L + 
Sbjct: 401 GIRQALSRARAMLSAELGPEKLLSP-----KRLEHVLEKSLHCSVLKPLRPILAARLRRR 455

Query: 703 HSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISIL 762
            + DGSL +L E   +  A      G   S+P    +E++ QK   + + YSP  ++  L
Sbjct: 456 LAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRL 515

Query: 763 LKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGE 822
           L+ CKL+Y ++     G+  GAD+FLP+L  VLA  +L E+LL  EYM EL++P+L  GE
Sbjct: 516 LQACKLLYMALRT-QEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGE 574

Query: 823 GSYYLTTTYGALEHIKSYDKI-TVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFIC 881
           G YYLT+   +L  +    +  T+      E++ S+  WE+RR       +    Q  + 
Sbjct: 575 GGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRL-----PATHCFQHLLR 629

Query: 882 VSYLEPEQ--QARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDAL 939
           V+Y +P     ++TLA   +     L   CA KF V +P    LF+  +    +L   AL
Sbjct: 630 VAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGAL 689

Query: 940 PHCI--KGYLL 948
            H +   GYL+
Sbjct: 690 AHRLPTTGYLV 700



 Score =  124 bits (310), Expect = 6e-28
 Identities = 104/327 (31%), Positives = 147/327 (44%), Gaps = 45/327 (13%)

Query: 45  PHRRG--ISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHF 102
           P R G  +S+ E+L+ T PVWLQL    A    +L     G FLVR+ ++ +   LC+  
Sbjct: 49  PQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRL 108

Query: 103 PSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILE 162
           P  +  S  V  + I E    + LEGS L+F D+ +LI  YC +RD+L   L+LP+AI  
Sbjct: 109 PEASGPSF-VSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHH 167

Query: 163 ASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACE 222
           A++  +LE I++LG+ FW SSLN   +RG PA        G P++  L+     A    E
Sbjct: 168 AATHKELEAISHLGIEFWSSSLNIKAQRG-PA--------GGPVLPQLK-----ARSPQE 213

Query: 223 IELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPP- 281
           ++   G   L F NP+F  D           LG         +      T   +P  PP 
Sbjct: 214 LDQGTG-AALCFFNPLFPGD-----------LGPTKREKFKRSFKVRVSTETSSPLSPPA 261

Query: 282 -PPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMT 340
            PPPPV           PVLP   P+    LP    +       +       P+ PPM +
Sbjct: 262 VPPPPV-----------PVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPS 310

Query: 341 CERLPCPTAGLGPLREEAMKPGAASSP 367
            + + C   G     EE   PG+  SP
Sbjct: 311 LQEVDC---GSPSSSEEEGVPGSRGSP 334


>gi|38348206 Ras and Rab interactor-like [Homo sapiens]
          Length = 452

 Score =  130 bits (328), Expect = 5e-30
 Identities = 82/243 (33%), Positives = 137/243 (56%), Gaps = 13/243 (5%)

Query: 637 STEMLQEIRTMMTQLKSYLLQSTELKALVD---PAL-HSEEELEAIVESALYKCVLKPLK 692
           +TE+LQ++R ++T L+ +L + + ++A+     P L   +E+    +E+A+ + VL PLK
Sbjct: 185 ATELLQDVRHLLTDLQDHLAKDSYIRAVFGSRGPGLPKKDEDPGPALETAVCQAVLAPLK 244

Query: 693 EAINSCLHQIHSKDGSLQQLKENQLVILATT----TTDLGVTTSVPEVPMMEKILQKFTS 748
            A+ + L  + + +  L++L+  Q  + A          G     P   +  +I ++   
Sbjct: 245 PALWTRLRTLRAPE--LRRLRRRQTALRAGAGPPGAQGPGPEGQSPAPALRSRIHERLAH 302

Query: 749 MHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARS-NLTEMLLNV 807
           +H A +P +K+++LL+ C+ +Y  +A G    P GAD FLP L   L  S ++ +  L+V
Sbjct: 303 LHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPDIGDTQLDV 362

Query: 808 EYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKIT--VTRQLSVEVQDSIHRWERRRT 865
           E++MEL+DP    GE  YYLTT +GAL HI  Y   T    R LS E + S+H+W RRRT
Sbjct: 363 EFLMELLDPDELRGEAGYYLTTWFGALHHIAHYQPETDRAPRGLSSEARASLHQWHRRRT 422

Query: 866 LNK 868
           L++
Sbjct: 423 LHR 425


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 126/447 (28%), Positives = 154/447 (34%), Gaps = 69/447 (15%)

Query: 157 PQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAE---PPRDRAPGF---PLVSSL 210
           PQA L +     LET          SSL PP  +  PA    PP +  P     PL ++ 
Sbjct: 500 PQAPLSSLIMPPLET---------QSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTAS 550

Query: 211 RP--TAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDA 268
            P  T H     C     +         P      S A P  Q P    PA   PP    
Sbjct: 551 APLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAP----PALASPPLQGL 606

Query: 269 TSPTSRWAPRRPPPPPPVLPLQPC-SPAQPPVLPALAPAPACPLPTSPPVPAPHV--TPH 325
            SP        PP  PP L L P  +P  PP  P L+P  A P P +P   A H+   P 
Sbjct: 607 PSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPL-ATPSPQAPNALAVHLLQAPF 665

Query: 326 APGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTA 385
           +P PP  P Q P       P   +   P       P  A+ PLQ  P+PP     +    
Sbjct: 666 SP-PPSPPVQAPFSPPASPPVSPSATPP---SQAPPSLAAPPLQVPPSPPASPPMSPSAT 721

Query: 386 PPRRRVSERVSLEDQSPGMAAEGDQL-SLPPQGTSDGPEDTPRESTE---QGQDTEVKAS 441
           PP              P +AA   Q+   PP      P  TP             +V  S
Sbjct: 722 PP----------PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPS 771

Query: 442 DPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMA-----LETPTPG 496
            P S+P  P  AK PP  PP       Q   + PA        + + +     L TP P 
Sbjct: 772 PPASLPMSP-LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830

Query: 497 ------------PPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLA-------SLSDS 537
                       PP    SP  QA  + PP      S S P    +LA       S S S
Sbjct: 831 APPVLAAPLLQVPPSPPASPTLQA-PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 889

Query: 538 LGVSVMATDQDSYSTSSTEEELEQFSS 564
             +S       S S +ST EEL  + S
Sbjct: 890 STLSGPDLAGHSSSATSTPEELRGYDS 916



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 87/289 (30%), Positives = 114/289 (39%), Gaps = 41/289 (14%)

Query: 248 PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQ--PCSPAQPPVLPALAP 305
           P   PP     A   PP S   SP++   P + PP     PLQ  P  PA PP+ P+  P
Sbjct: 664 PFSPPPSPPVQAPFSPPASPPVSPSAT-PPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 722

Query: 306 APACP---------LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERL---PCPTAGL-- 351
            P  P         +P SPP  +P ++P A  P   P  PP++    L   P P A L  
Sbjct: 723 PPQAPPPLAAPPLQVPPSPPA-SPPMSPSATPP---PRVPPLLAAPPLQVPPSPPASLPM 778

Query: 352 GPLREEAMK--PGAASSPLQQVPAPPLPAKKNLPTAPPRR-RVSERVSLEDQSPGMAAEG 408
            PL +   +  P  A+ PLQ +P+PP       P +P     +S   +   Q+P + A  
Sbjct: 779 SPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA-A 837

Query: 409 DQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISR 468
             L +PP   +      PR     G DT V      S P L       P PPP     SR
Sbjct: 838 PLLQVPPSPPASPTLQAPRRPPTPGPDTSV------SGPRLTLALAPGPPPPP-----SR 886

Query: 469 QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQA 517
             +STL  P    +L   + +  T TP   R   S         PP  A
Sbjct: 887 SPSSTLSGP----DLAGHSSS-ATSTPEELRGYDSGPEGGAAASPPPDA 930



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 98/342 (28%), Positives = 127/342 (37%), Gaps = 75/342 (21%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVL--PLQ--PCSPAQPPV 299
            S+  P+  PP    P   +PP+  A+ P S  A   P  PPP+   PLQ  P  PA PP+
Sbjct: 688  SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPM 747

Query: 300  LPALAPAPACP---------LPTSPPVPAPHVTPHAPGPPDHPNQ---PPMMTCERLPCP 347
             P+  P P  P         +P SPP   P ++P A  PP  P     PP+      P  
Sbjct: 748  SPSATPPPRVPPLLAAPPLQVPPSPPASLP-MSPLAKPPPQAPPALATPPLQALPSPPAS 806

Query: 348  TAGLGPLREEA------------MKPGAASSPLQQVP-----APPLPAKKNLPTAPPRRR 390
              G  P    A              P   ++PL QVP     +P L A +  PT  P   
Sbjct: 807  FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS 866

Query: 391  VS-ERVSLE---------DQSPGMAAEGDQLSLPPQGTSDGPEDTPRE--STEQGQDTEV 438
            VS  R++L           +SP     G  L+    G S     TP E    + G +   
Sbjct: 867  VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA----GHSSSATSTPEELRGYDSGPEGGA 922

Query: 439  KASDPHSMPELPRTAKQP------PVPPPRKKRISRQLASTLPAPLENAE-------LCT 485
             AS P   P+    A  P      P PP     ++ + A   P P   A        LCT
Sbjct: 923  AASPP---PDAELAACHPAAWSRGPAPP-----LAFRGAPGAPLPWPPATGPGSADGLCT 974

Query: 486  ----QAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQS 523
                +     TP PG    G SP +  G     A A A S+S
Sbjct: 975  IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS 1016



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 107/406 (26%), Positives = 145/406 (35%), Gaps = 65/406 (16%)

Query: 154 LRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPT 213
           L+ P +   +SS T L + A  G          P  RG P  P     P    + +LRP 
Sbjct: 234 LQRPASRSLSSSATPLSSPARSG----------PSARGTPRAPAHPSQPKPKGLQALRPP 283

Query: 214 AHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTS 273
                           D    + P+      S+ P   P      ARP+PP  +A +P  
Sbjct: 284 Q---------VTPPRKDAAPALGPL------SSSPLATPSPSGTKARPVPPPDNAATPL- 327

Query: 274 RWAPRRPPPPPPV---LPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
              P   PP PP+   LPL P SP+ PP L  L   PA P   +PP      TP    PP
Sbjct: 328 ---PATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPP---SMTTPPMQAPP 381

Query: 331 DHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS--PLQQVPAPPLPAKKNLPTAPPR 388
                PP+     L  P+    P       P A SS      + +P L A  +  T  PR
Sbjct: 382 SLQTIPPIQVPHSLTSPSLQAPP------SPLALSSLQATTSLGSPTLQATHSFLTMSPR 435

Query: 389 R------RVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASD 442
           +        S   S    SP + A     + PP  TS  P  +P  S       +  +S 
Sbjct: 436 QTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSL 495

Query: 443 PHSMPELPRTA-------KQPPVPPPRKKRIS--------RQLASTLPAPLENAELCTQA 487
               P+ P ++        Q  + PP  +             L S  P PL+ A      
Sbjct: 496 ASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTT 555

Query: 488 MALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLAS 533
             LETP    P   Q+P S   T  PP   ++ +   P+   +LAS
Sbjct: 556 PHLETPPCPAPCPLQAPPSPL-TTPPPETPSSIATPPPQAPPALAS 600



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 66/281 (23%), Positives = 94/281 (33%), Gaps = 47/281 (16%)

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKP 361
           A AP    P P   P P P VTP A                       G  PL E A   
Sbjct: 19  ARAPGLLTPRPPGSPRPPPPVTPAALRVLG-------------AAGAVGRKPLAERAGGI 65

Query: 362 GAASSPLQQVPAPPL----PAKKNLPTAPPRRRVSERV-SLEDQSPGMAAEGDQLS---L 413
           G A+ P     A P      + +N  + PP     ER    ++ SPG  +   + S    
Sbjct: 66  GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 414 PPQGTSDGPEDTPRESTEQGQDTEV-KASDPHSMPELPRTAKQPPVPPPRKKRISRQLAS 472
           P      G   +  E+  +G+ TE  K S   +      +   P  P P   R SR   +
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 473 T--LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGS 530
              LP P  +A             P PP EG   +  + ++H   + +  ++  P     
Sbjct: 186 EVGLPRPAPSAR------------PRPPTEGPRKSVSSASEHSTTEPSPAARRRP----- 228

Query: 531 LASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKP 571
                 S G  +      S S+S+T       S PS +  P
Sbjct: 229 ------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP 263



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 69/299 (23%), Positives = 100/299 (33%), Gaps = 44/299 (14%)

Query: 277 PRRPPPPPPVLP--LQPCSPA----QPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
           P  P PPPPV P  L+    A    + P+           +P S P   P  +       
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 331 DHPNQPPMMTCERL-PCPTAGLGPLREE-----AMKPGAASSPLQQVPAPPLPAKKNLPT 384
                P     ER  P      GP+          +PG       ++ A    A+     
Sbjct: 90  PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 149

Query: 385 APPR-------RRVSERVSLEDQSPGMA----AEGDQLSLPPQGTSDGPEDTPRESTEQG 433
           AP R       RR +   +    SP MA    A G ++ LP       P   PR  TE  
Sbjct: 150 APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP----RPAPSARPRPPTEGP 205

Query: 434 QDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETP 493
           + +   AS+  +    P   ++P      ++  SR L+S+             A  L +P
Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS-------------ATPLSSP 252

Query: 494 TPGPPREGQSPASQAGTQHPP---AQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDS 549
               P    +P + A    P     QA    Q +P  K +  +L   L  S +AT   S
Sbjct: 253 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPS 310


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 81/306 (26%), Positives = 112/306 (36%), Gaps = 36/306 (11%)

Query: 240  IEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQ--- 296
            ++   + +P   PP    P  P PP      P        PPPPPP +P Q  +PA    
Sbjct: 746  MQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPP--------PPPPPPSMP-QQAAPAMKSS 796

Query: 297  -PPVLPALAPAPACPLP----------TSP--PVPAPHVTPHAPGPPDHPNQPPMMTCER 343
             PP +    P     LP          T P   +P P + PH P PP+H + PP +    
Sbjct: 797  PPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEH-STPPHLNQHA 855

Query: 344  LPCPTAGLGPLREEAMKPGAASSPLQQVPAPP---LPAKKNLPTAP-PRRRVSERVSLED 399
            +  P A    L ++  +P   ++ L   PA P    PA    P  P P      +V LED
Sbjct: 856  VVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLED 915

Query: 400  Q---SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQP 456
            +   +P + +   QL L        P         Q Q        PH   +     + P
Sbjct: 916  EEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPP 975

Query: 457  PVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQ 516
            P PPP+ +   +Q     P P+    L     +     P PP+  Q P    G Q PP Q
Sbjct: 976  PPPPPQPQPPPQQQHQPPPRPV---HLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQ 1032

Query: 517  ATAHSQ 522
                 Q
Sbjct: 1033 PAKPQQ 1038



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 43/145 (29%), Positives = 59/145 (40%), Gaps = 16/145 (11%)

Query: 262 LPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL----PALAPAPACPLPTSPPV 317
           +P T+ A++P     P+  P PPPV       PA  P L    P +   P  PL T PPV
Sbjct: 196 VPNTTQASTPPQTQTPQ--PNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPV 253

Query: 318 PAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPA-PPL 376
           P     P AP P    + PP++     P  T   G  R+          P+ + P+ PP 
Sbjct: 254 PPQPQPPPAPAPQPVQSHPPIIAATPQPVKTK-KGVKRKADTTTPTTIDPIHEPPSLPPE 312

Query: 377 PAKKNL--------PTAPPRRRVSE 393
           P    L        P  PP++ V +
Sbjct: 313 PKTTKLGQRRESSRPVKPPKKDVPD 337



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 85/358 (23%), Positives = 114/358 (31%), Gaps = 45/358 (12%)

Query: 248  PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPV-----LPLQPCSPAQPP--VL 300
            P   P L   P  P PP   A  P        PP PP       L LQ     QPP  +L
Sbjct: 888  PAVSPALTQTPLLPQPPM--AQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLL 945

Query: 301  PALA----PAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR- 355
            P++     P P  P P  P V         P PP  P  PP    +  P P   L P++ 
Sbjct: 946  PSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRP-VHLQPMQF 1004

Query: 356  ----EEAMKPGAASSPLQ---QVPAPPLPAKKNLPTA---PPRRRVSERVS---LEDQSP 402
                ++   P     P     Q P PP PAK          PR   S+  S   L +   
Sbjct: 1005 STHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPS 1064

Query: 403  GMAAEGDQLSL---------PPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTA 453
             +     Q+S          P Q      ++    S  Q Q   V   +    P +    
Sbjct: 1065 PLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEP 1124

Query: 454  KQPPV-PPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQH 512
              P + P P K   S +    LP   E   +      +  P    P  G +P      Q 
Sbjct: 1125 FSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPG-APDKDKQKQE 1183

Query: 513  PPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
            P            +  GS ASL      +  +T        S+ +  EQF   + +K+
Sbjct: 1184 PKTPVAPKKDLKIKNMGSWASLVQKHPTTPSST------AKSSSDSFEQFRRAAREKE 1235



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 48/200 (24%), Positives = 67/200 (33%), Gaps = 27/200 (13%)

Query: 334 NQPPMMTCERLPCPTAGLGPLREEA--MKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRV 391
           N+ P    E +     G G  R+E    KPG ++ P     + P   +   P  PP +  
Sbjct: 162 NELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQAT 221

Query: 392 SERV-----SLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSM 446
                     L  Q+P M        +PPQ     P  TP     Q Q     A  P  +
Sbjct: 222 PHPFPAVTPDLIVQTPVMTV------VPPQ-----PLQTPPPVPPQPQPPPAPAPQP--V 268

Query: 447 PELPRTAKQPPVPPPRKKRISRQLASTLPAPLENA-ELCTQAMALETPTPGPPREGQSPA 505
              P      P P   KK + R+  +T P  ++   E  +     +T   G  RE   P 
Sbjct: 269 QSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPV 328

Query: 506 SQAGTQHPPAQATAHSQSSP 525
                  PP +    SQ  P
Sbjct: 329 K------PPKKDVPDSQQHP 342


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 102/367 (27%), Positives = 136/367 (37%), Gaps = 56/367 (15%)

Query: 184 LNPPQERGKPAEPPRDRAPGFPL--VSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIE 241
           L PP+E   P  PP + +P  P    S L P         E+  S   + L    P+  E
Sbjct: 441 LPPPEE--SPLSPPPEESPTSPPPEASRLSPPPE------ELPASPLPEALHLSRPL--E 490

Query: 242 DCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPP---PPPPVL--PLQP---CS 293
           +   + P ++ PL        PP S   SP    +P  PP   PP P L  PL P    S
Sbjct: 491 ESPLSPPPEESPLSP------PPESSPFSPLEE-SPLSPPEESPPSPALETPLSPPPEAS 543

Query: 294 PAQPPVLPALAPAPACPLPTSPP------VPAPHVTPHAPGPPDHPNQPPMMTCERLPCP 347
           P  PP   +    P   LPTSPP       P P  +P +P P + P  PP       P  
Sbjct: 544 PLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFP-- 601

Query: 348 TAGLGPLREEAMKPGAASSPLQQVPAPP--LPAKKNLPTAPPRRRVSERVSLEDQSPGMA 405
                P  E  + P    SPL   P      P  ++ P +PP          E       
Sbjct: 602 -----PFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPL 656

Query: 406 AEGDQLSLPPQGT--SDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRK 463
               +LS PP+ +  S  PE++P   T    +    +  P   P  P     P  PPP  
Sbjct: 657 PVVSRLSPPPEESPLSPPPEESP---TSPPPEASRLSPPPEDSPTSPPPEDSPASPPPED 713

Query: 464 KRISRQLAST--LPAPLENAELCTQAMALETP--TPGPPREGQSPASQAGTQHPPAQATA 519
             +S  L  +  LP P E  +LC ++   E P  +P P     SP  +     P A+   
Sbjct: 714 SLMSLPLEESPLLPLP-EEPQLCPRS---EGPHLSPRPEEPHLSPRPEEPHLSPQAE-EP 768

Query: 520 HSQSSPE 526
           H    PE
Sbjct: 769 HLSPQPE 775



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 98/367 (26%), Positives = 138/367 (37%), Gaps = 61/367 (16%)

Query: 179 FWDSSLNPPQERGKPAEPPR-DRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNP 237
           F +S L+PP E    + PP   R    P  S + P   ++  +   E S    RL+   P
Sbjct: 549 FEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEAS----RLF---P 601

Query: 238 IFIEDCSSALPTDQPPLGNCP--ARPLPPTSDAT-SPTSRWAPRRPPP------------ 282
            F E+   + P ++ PL   P  +R  PP  D+  SP    +P  PPP            
Sbjct: 602 PF-EESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660

Query: 283 ----PPPVLPLQPC---SPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQ 335
               PP   PL P    SP  PP   +    P    PTSPP   P  +P +P P D    
Sbjct: 661 RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPP---PEDSPASPPPEDSLMS 717

Query: 336 PPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPP-LPAKKNLPTAPPRRRVSER 394
            P+     LP P        E  + P +    L   P  P L  +   P   P+      
Sbjct: 718 LPLEESPLLPLP-------EEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAE-EPH 769

Query: 395 VSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAK 454
           +S + + P + A  ++  L PQ  ++GP  +P       Q  E+  S     P L    +
Sbjct: 770 LSPQPEEPCLCAVPEEPHLSPQ--AEGPHLSP-------QPEELHLSPQTEEPHLSPVPE 820

Query: 455 QPPV-PPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPRE------GQSPASQ 507
           +P + P P +  +S Q  S  P      E    +  LE P   P  E      GQ PA +
Sbjct: 821 EPCLSPQPEESHLSPQ--SEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPE 878

Query: 508 AGTQHPP 514
                PP
Sbjct: 879 ELPLFPP 885



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 93/371 (25%), Positives = 134/371 (36%), Gaps = 45/371 (12%)

Query: 162 EASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCAC 221
           E S  + L  ++ L     +S L+PP E   P  PP       P  S L P   D+  + 
Sbjct: 649 EVSRLSPLPVVSRLSPPPEESPLSPPPEE-SPTSPP-------PEASRLSPPPEDSPTSP 700

Query: 222 EIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPP 281
             E S  +           ED   +LP ++ PL   P  P         P S      P 
Sbjct: 701 PPEDSPASPP--------PEDSLMSLPLEESPLLPLPEEP------QLCPRSEGPHLSPR 746

Query: 282 PPPPVLPLQPCSPAQPPVL--PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMM 339
           P  P L  +P  P   P    P L+P P  P   + P   PH++P A GP   P    + 
Sbjct: 747 PEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVP-EEPHLSPQAEGPHLSPQPEELH 805

Query: 340 TCERLPCPTAGLGPLREE-AMKPGAAS---SPLQQVPA-PPLPAKKNLPTAPPRRRVSER 394
              +   P   L P+ EE  + P       SP  + P   P P + +L     +  +S R
Sbjct: 806 LSPQTEEP--HLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPR 863

Query: 395 VSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAK 454
                + PG     ++L L P      P   P  S   G+    +  +P   P LP   +
Sbjct: 864 PEKPPEEPGQCPAPEELPLFP------PPGEPSLSPLLGEPALSEPGEPPLSP-LP---E 913

Query: 455 QPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPP 514
           + P+ P  +  +S QL    P P   + + T   A   P   P  E + P    G   P 
Sbjct: 914 ELPLSPSGEPSLSPQLMPPDPLPPPLSPIIT---AAAPPALSPLGELEYPFGAKGDSDPE 970

Query: 515 AQATAHSQSSP 525
           +   A    +P
Sbjct: 971 SPLAAPILETP 981



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 89/350 (25%), Positives = 118/350 (33%), Gaps = 78/350 (22%)

Query: 247  LPTDQPPLGNCPARPLP------PTSDATSPTSRWAPRRPP---------PPPPVLPLQP 291
            +P     LG+ P    P      PT+ A   TS     +PP         P    L L P
Sbjct: 2106 IPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPP 2165

Query: 292  CSPAQPPVLPALAPAPACPL----PTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLP-- 345
              PAQ P       APA PL    PT+PP   P+     P P   P QPPM+     P  
Sbjct: 2166 QVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPY-----PSPTGAPAQPPMLGASSRPGA 2220

Query: 346  -----CPTAGLGPLREEAMKPGAASSP----LQQVPAPPLP----AKKNLPTAPPRRRVS 392
                   T   G  R +   P     P    L  +  P  P     K + P   P     
Sbjct: 2221 GQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGE 2280

Query: 393  ERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRT 452
             R +LE +   + A       P  G      D+P   T  G   E+K  D    P  PR 
Sbjct: 2281 SRKALEVKKEELGASSPSYGPPNLGF----VDSPSSGTHLG-GLELKTPDVFKAPLTPRA 2335

Query: 453  AKQPPVPP-----PRKKRISRQLASTLPA------PLENAELCTQAMALETPTPGPP--- 498
            ++  P  P     P++   ++ LA + P+      P    +   Q      P P PP   
Sbjct: 2336 SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESC 2395

Query: 499  --------------REGQSPASQAGTQHP------PAQATAHSQSSPEFK 528
                          R   SP SQ+ +Q P       A+A   S  +P F+
Sbjct: 2396 CALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQ 2445



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 70/285 (24%), Positives = 100/285 (35%), Gaps = 28/285 (9%)

Query: 248 PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPV-LPLQPCSPAQPPVLPALAPA 306
           PTD+P       +  P     TS        +P  P P+    +P   A   + P L   
Sbjct: 381 PTDEPDALYVACQGQPKGGHVTS-------MQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433

Query: 307 PACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS 366
               +P  PP   P  +P +P P + P  PP       P P         EA+     S 
Sbjct: 434 LNEEMPLLPP---PEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALH---LSR 487

Query: 367 PLQQVPAPPLPAKKNL---PTAPPRRRVSER-VSLEDQSPGMAAEGDQLSLPPQGT---- 418
           PL++ P  P P +  L   P + P   + E  +S  ++SP   A    LS PP+ +    
Sbjct: 488 PLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSP 547

Query: 419 --SDGPEDTPRESTEQGQDTEVK--ASDPHSMPELPRTAKQPPVPPPRKKRISRQL-AST 473
              + P   P E        E    +  P   P  P   + P  PPP   R+      S 
Sbjct: 548 PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESP 607

Query: 474 LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQAT 518
           L  P E + L     A    +P P     SP  +     PP + +
Sbjct: 608 LSPPPEESPLSPPPEASRL-SPPPEDSPMSPPPEESPMSPPPEVS 651



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 57/194 (29%), Positives = 70/194 (36%), Gaps = 30/194 (15%)

Query: 251  QPPLGNCPARPLPPTSD-ATSPTSRWAPRRPPPPP---------PVLPLQPCSPAQPPVL 300
            QP LG  P     P  +    P  +  PR P PP          PV P  P S  Q P  
Sbjct: 4260 QPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKR 4319

Query: 301  PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTA------GLGPL 354
            P+  P+P+  LPT   +P  H  P  P P     +PP           A      GLGP 
Sbjct: 4320 PSQLPSPSSQLPTEAQLPPTH--PGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPW 4377

Query: 355  -----REEAMKPGAAS---SPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAA 406
                   E  KP  +S     L QV    +P    L      R   E  +L  QS    A
Sbjct: 4378 DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPR--EEPCALGAQSVKREA 4435

Query: 407  EGDQLSLPPQGTSD 420
             G+ +  P  GTS+
Sbjct: 4436 NGEPIGAP--GTSN 4447



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 85/364 (23%), Positives = 126/364 (34%), Gaps = 67/364 (18%)

Query: 248  PTDQPPLGNCPAR---PL--PPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPA 302
            P ++P  G CPA    PL  PP   + SP         P  PP+ PL    P  P   P+
Sbjct: 867  PPEEP--GQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPS 924

Query: 303  LAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLG---------- 352
            L+P    P P  PP+ +P +T  AP        P +     L  P    G          
Sbjct: 925  LSPQLMPPDPLPPPL-SPIITAAAP--------PALSPLGELEYPFGAKGDSDPESPLAA 975

Query: 353  PLREEAMKPGAASSPLQQVPAPP--LPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQ 410
            P+ E  + P   ++     P PP  LP     P  P    + E +      P   +   Q
Sbjct: 976  PILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPL------PPQCSPLLQ 1029

Query: 411  LSLPPQGTSDG-------PEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRK 463
             SL PQ +          P   P   +  G+   V  SD   + E+    +   V  P  
Sbjct: 1030 HSLVPQNSPPSQCSPPALPLSVPSPLSPIGK--VVGVSDEAELHEM----ETEKVSEPEC 1083

Query: 464  KRISRQLASTLPAPLENAELCTQAMALETPTPGPPRE-----GQSPASQAGTQHP---PA 515
              +     S LP+P+ +       ++   P+P P  +     G+  A   G   P   P 
Sbjct: 1084 PALEPSATSPLPSPMGD-------LSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPE 1136

Query: 516  QATAHSQSSPEFKGSLA-----SLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
                    + E KGS        L+    + V    + +    S  EE E+  +P     
Sbjct: 1137 PGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTP 1196

Query: 571  PSMI 574
            P++I
Sbjct: 1197 PTLI 1200



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 66/289 (22%), Positives = 98/289 (33%), Gaps = 29/289 (10%)

Query: 261  PLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAP 320
            PL P +    P S     RP  PPP   L P  P+ P +          P   + P   P
Sbjct: 2330 PLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFR--------PGSYTDPYAQP 2381

Query: 321  HVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKK 380
             +TP        P  PP  +C  LP  +    P       P + SS    +   PL A+ 
Sbjct: 2382 PLTP-------RPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEA 2434

Query: 381  NLPT-APPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVK 439
              P+   PR +  +  S     P        L  PP+     P +   ++      +   
Sbjct: 2435 FCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPR---PQPPEVAFKAGSLAHTSLGA 2491

Query: 440  ASDPHSMPELPR---TAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPG 496
               P ++P  P     AK P   PP   R S    + +  P        QA+   +  P 
Sbjct: 2492 GGFPAALPAGPAGELHAKVPSGQPPNFVR-SPGTGAFVGTPSPMRFTFPQAVGEPSLKPP 2550

Query: 497  PPREGQSPASQAGTQHPPA------QATAHSQSSPEFKGSLASLSDSLG 539
             P+ G  P     +   P       Q+T ++ ++  F  S + L  S G
Sbjct: 2551 VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSG 2599



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 72/316 (22%), Positives = 105/316 (33%), Gaps = 30/316 (9%)

Query: 187  PQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSA 246
            P    +P EP     P  P +S      H +    E+ LS   +    ++P+  E C S 
Sbjct: 768  PHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEP-HLSPVPEEPCLSP 826

Query: 247  LPTDQ--PPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALA 304
             P +    P    P     P     SP     P  P P  P        P +P   PA  
Sbjct: 827  QPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKP--------PEEPGQCPAPE 878

Query: 305  PAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAA 364
              P  P P  P + +P +   A   P  P   P+   E LP   +G   L  + M P   
Sbjct: 879  ELPLFPPPGEPSL-SPLLGEPALSEPGEPPLSPLP--EELPLSPSGEPSLSPQLMPPDPL 935

Query: 365  SSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAE--GDQLSLPPQGTSDGP 422
              PL  +     P   + P          +   + +SP +AA      +S PP+     P
Sbjct: 936  PPPLSPIITAAAPPALS-PLGELEYPFGAKGDSDPESP-LAAPILETPISPPPEANCTDP 993

Query: 423  EDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAE 482
            E  P         + V  + P  M          P+PP     +   L   +P     ++
Sbjct: 994  EPVPPMILPPSPGSPVGPASPILM---------EPLPPQCSPLLQHSL---VPQNSPPSQ 1041

Query: 483  LCTQAMALETPTPGPP 498
                A+ L  P+P  P
Sbjct: 1042 CSPPALPLSVPSPLSP 1057



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 77/300 (25%), Positives = 103/300 (34%), Gaps = 43/300 (14%)

Query: 248  PTDQPPLGNCPARPL-PPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPA 306
            P   PP  +    P  PP   A+S      P      PP  P    S   P + P     
Sbjct: 2193 PPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSL 2252

Query: 307  PACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTC--ERLPCPTAGLGPLREEAMKPGAA 364
                +P SP V     +     PP        +    E L   +   GP        G  
Sbjct: 2253 DNLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGP-----PNLGFV 2307

Query: 365  SSPLQQVPAPPLPAK-KNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPE 423
             SP        L  K  ++  AP   R S+   +E QSPG+     Q   P Q  +  P 
Sbjct: 2308 DSPSSGTHLGGLELKTPDVFKAPLTPRASQ---VEPQSPGLGLR-PQEPPPAQALAPSPP 2363

Query: 424  DTPRESTEQGQDTEVKASDPHSMPEL-PRTAKQPPVP------PPR--------KKRISR 468
              P +    G  T     DP++ P L PR   QPP P      PPR        +   S 
Sbjct: 2364 SHP-DIFRPGSYT-----DPYAQPPLTPR--PQPPPPESCCALPPRSLPSDPFSRVPASP 2415

Query: 469  QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFK 528
            Q  S+  +PL    L  +A     P+P  PR  QSP   +    PP++  +    +P  K
Sbjct: 2416 QSQSSSQSPLTPRPLSAEAFC---PSPVTPR-FQSPDPYS---RPPSRPQSRDPFAPLHK 2468



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 32/99 (32%), Positives = 39/99 (39%), Gaps = 19/99 (19%)

Query: 248  PTDQPP--------LGNCPARPL--PPTSDATSPTSRWAPRRPPPPPPVLPLQPCSP-AQ 296
            P  +PP        + N   R L  PP  + + P S  AP    PP   L   P  P A+
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943

Query: 297  PPVLPALAPAPACPLPTSPPV--PAPHVTPHAPGPPDHP 333
            PPV     P+P  PL +SP    P P   P   G    P
Sbjct: 4944 PPV-----PSP-LPLASSPESARPKPRARPPEEGEDSRP 4976



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 30/81 (37%), Positives = 34/81 (41%), Gaps = 8/81 (9%)

Query: 261  PLPPTSDA-TSPTSRWAPRRPPPPPPVLPLQPCSPAQP-PVLPALAP---APACPLPTSP 315
            P PPT  + T   S    R+   PPP  P  P SP  P P  P   P    P  PL   P
Sbjct: 4886 PEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPL-AEP 4944

Query: 316  PVPAPHVTPHAPGPPDHPNQP 336
            PVP+P   P A  P     +P
Sbjct: 4945 PVPSP--LPLASSPESARPKP 4963



 Score = 30.8 bits (68), Expect = 6.5
 Identities = 54/248 (21%), Positives = 90/248 (36%), Gaps = 15/248 (6%)

Query: 278  RRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQP- 336
            R+P  P P++P QP + A   +   LAP+ A        +   H    A   P   +QP 
Sbjct: 3321 RQPGLPQPLMPTQPPAHA---LQQRLAPSMAMVSNQGHMLSGQH-GGQAGLVPQQSSQPV 3376

Query: 337  ----PMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLP---AKKNLPTAPPRR 389
                PM T     C       ++++        + L +  A  +    AK  +      +
Sbjct: 3377 LSQKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIK 3436

Query: 390  RVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL 449
            +V  + S+   +PGM  +  Q+SL  Q  S GP    +     G   E  A DP      
Sbjct: 3437 KVMAQGSI-GVAPGMNRQ--QVSLLAQRLSGGPSSDLQNHVAAGSGQERSAGDPSQPRPN 3493

Query: 450  PRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAG 509
            P T  Q  +    +++    L  T        ++  + + +   +       Q  A +AG
Sbjct: 3494 PPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAG 3553

Query: 510  TQHPPAQA 517
             + P A A
Sbjct: 3554 REFPEADA 3561


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 125/460 (27%), Positives = 162/460 (35%), Gaps = 95/460 (20%)

Query: 154 LRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPT 213
           L+ P +   +SS T L + A  G          P  RG P  P     P    + +LRP 
Sbjct: 234 LQRPASRSLSSSATPLSSPARSG----------PSARGTPRAPAHPSQPKPKGLQALRPP 283

Query: 214 A-----HDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDA 268
                  DA  A     S         +P+     S+AL +  PP        LP T  +
Sbjct: 284 QVTPPRKDAAPALGPLSS---------SPLATPSPSAALQSQAPPT-------LPATPHS 327

Query: 269 TSPTSRWA---PRRPPPP--PPVLPLQPCSPAQPP----------VLPA----LAPAPAC 309
           +S T + A   P  PP P  PP L   P  PA PP           L A    L   P  
Sbjct: 328 SSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS 387

Query: 310 PLPTSPPVPAPHVT-PHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPL 368
           PL T PP   P +  P    PP  P  PP+        P A   P    A+      +P 
Sbjct: 388 PLATPPPQAPPALALPPLQAPPSPPASPPL-------SPLATPSPQAPNALAVHLLQAPF 440

Query: 369 QQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRE 428
              P+PP+ A  + P +PP   VS   +   Q+P        L+ PP      P  +P  
Sbjct: 441 SPPPSPPVQAPFSPPASPP---VSPSATPPSQAP------PSLAAPPLQVPPSPPASPPM 491

Query: 429 STEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAM 488
           S       +  A  P + P L + AK PP  PP       Q   + PA        + + 
Sbjct: 492 SPSATPPPQ--APPPLAAPPL-QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 548

Query: 489 A-----LETPTPG------------PPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSL 531
           +     L TP P             PP    SP  QA  + PP      S S P    +L
Sbjct: 549 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA-PRRPPTPGPDTSVSGPRLTLAL 607

Query: 532 A-------SLSDSLGVSVMATDQDSYSTSSTEEELEQFSS 564
           A       S S S  +S       S S +ST EEL  + S
Sbjct: 608 APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 647



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 93/326 (28%), Positives = 117/326 (35%), Gaps = 67/326 (20%)

Query: 248 PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQ--PCSPAQPPVLPALAP 305
           P   PP     A   PP S   SP++   P + PP     PLQ  P  PA PP+ P+  P
Sbjct: 439 PFSPPPSPPVQAPFSPPASPPVSPSAT-PPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 497

Query: 306 APACPLP-TSPPV----PAPHVTPHAPGPP---------DHPNQPPMMTCERLPCPTAGL 351
            P  P P  +PP+    P P   P    PP           P Q P      LP      
Sbjct: 498 PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLAT 557

Query: 352 GPLREEAMKPGAASSPLQQVP-----APPLPAKKNLPTAPPRRRVS-ERVSLE------- 398
            P       P   ++PL QVP     +P L A +  PT  P   VS  R++L        
Sbjct: 558 PP----PQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613

Query: 399 --DQSPGMAAEGDQLSLPPQGTSDGPEDTPRE--STEQGQDTEVKASDPHSMPELPRTAK 454
              +SP     G  L+    G S     TP E    + G +    AS P   P+    A 
Sbjct: 614 PPSRSPSSTLSGPDLA----GHSSSATSTPEELRGYDSGPEGGAAASPP---PDAELAAC 666

Query: 455 QP------PVPPPRKKRISRQLASTLPAPLENAE-------LCT----QAMALETPTPGP 497
            P      P PP     ++ + A   P P   A        LCT    +     TP PG 
Sbjct: 667 HPAAWSRGPAPP-----LAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGA 721

Query: 498 PREGQSPASQAGTQHPPAQATAHSQS 523
              G SP +  G     A A A S+S
Sbjct: 722 LDPGPSPGTSGGKAAAGAGAGASSRS 747



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 66/281 (23%), Positives = 94/281 (33%), Gaps = 47/281 (16%)

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKP 361
           A AP    P P   P P P VTP A                       G  PL E A   
Sbjct: 19  ARAPGLLTPRPPGSPRPPPPVTPAALRVLG-------------AAGAVGRKPLAERAGGI 65

Query: 362 GAASSPLQQVPAPPL----PAKKNLPTAPPRRRVSERV-SLEDQSPGMAAEGDQLS---L 413
           G A+ P     A P      + +N  + PP     ER    ++ SPG  +   + S    
Sbjct: 66  GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 414 PPQGTSDGPEDTPRESTEQGQDTEV-KASDPHSMPELPRTAKQPPVPPPRKKRISRQLAS 472
           P      G   +  E+  +G+ TE  K S   +      +   P  P P   R SR   +
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 473 T--LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGS 530
              LP P  +A             P PP EG   +  + ++H   + +  ++  P     
Sbjct: 186 EVGLPRPAPSAR------------PRPPTEGPRKSVSSASEHSTTEPSPAARRRP----- 228

Query: 531 LASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKP 571
                 S G  +      S S+S+T       S PS +  P
Sbjct: 229 ------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP 263



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 68/294 (23%), Positives = 99/294 (33%), Gaps = 49/294 (16%)

Query: 277 PRRPPPPPPVLP--LQPCSPA----QPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
           P  P PPPPV P  L+    A    + P+           +P S P   P  +       
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 331 DHPNQPPMMTCERL-PCPTAGLGPLREE-----AMKPGAASSPLQQVPAPPLPAKKNLPT 384
                P     ER  P      GP+          +PG       ++ A    A+     
Sbjct: 90  PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 149

Query: 385 APPR-------RRVSERVSLEDQSPGMA----AEGDQLSLPPQGTSDGPEDTPRESTEQG 433
           AP R       RR +   +    SP MA    A G ++ LP       P   PR  TE  
Sbjct: 150 APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP----RPAPSARPRPPTEGP 205

Query: 434 QDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLAS-----------------TLPA 476
           + +   AS+  +    P   ++P      ++  SR L+S                 T  A
Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 477 PLENAELCTQAM-ALETPTPGPPREGQSPA----SQAGTQHPPAQATAHSQSSP 525
           P   ++   + + AL  P   PPR+  +PA    S +    P   A   SQ+ P
Sbjct: 266 PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 104/371 (28%), Positives = 132/371 (35%), Gaps = 72/371 (19%)

Query: 246 ALPTDQPPLGNCPARP---LPPTSDA--------TSPTSRWAPRRPPPP--PPVLPLQPC 292
           A P+   P G    RP    PP  DA        +SP +  +P  PP P  PP L   P 
Sbjct: 258 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317

Query: 293 SPAQPP----------VLPA----LAPAPACPLPTSPPVPAPHVT-PHAPGPPDHPNQPP 337
            PA PP           L A    L   P  PL T PP   P +  P    PP  P  PP
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 377

Query: 338 MMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSL 397
           +        P A   P    A+      +P    P+PP+ A  + P +PP   VS   + 
Sbjct: 378 L-------SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP---VSPSATP 427

Query: 398 EDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPP 457
             Q+P        L+ PP      P  +P  S       +  A  P + P L + AK PP
Sbjct: 428 PSQAP------PSLAAPPLQVPPSPPASPPMSPSATPPPQ--APPPLAAPPL-QLAKPPP 478

Query: 458 VPPPRKKRISRQLASTLPAPLENAELCTQAMA-----LETPTPG------------PPRE 500
             PP       Q   + PA        + + +     L TP P             PP  
Sbjct: 479 QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538

Query: 501 GQSPASQAGTQHPPAQATAHSQSSPEFKGSLA-------SLSDSLGVSVMATDQDSYSTS 553
             SP  QA  + PP      S S P    +LA       S S S  +S       S S +
Sbjct: 539 PASPTLQA-PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597

Query: 554 STEEELEQFSS 564
           ST EEL  + S
Sbjct: 598 STPEELRGYDS 608



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 102/373 (27%), Positives = 128/373 (34%), Gaps = 53/373 (14%)

Query: 186 PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
           PPQ     A PP    P  P    L P A  +  A    L+V   +  F  P      + 
Sbjct: 354 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNA-LAVHLLQAPFSPPPSPPVQAP 412

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAP 305
             P   PP+      P        +P  +  P  PP  PP+ P     P  PP L A   
Sbjct: 413 FSPPASPPVSPSATPPSQAPPSLAAPPLQ-VPPSPPASPPMSPSATPPPQAPPPLAAPPL 471

Query: 306 APACPLPTSPPVPAPHVTPHAPGPP-DHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAA 364
             A P P +PP  A       P PP   P Q P      LP       P       P   
Sbjct: 472 QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP----PQAPPVL 527

Query: 365 SSPLQQVP-----APPLPAKKNLPTAPPRRRVS-ERVSL---------EDQSPGMAAEGD 409
           ++PL QVP     +P L A +  PT  P   VS  R++L           +SP     G 
Sbjct: 528 AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 587

Query: 410 QLSLPPQGTSDGPEDTPRE--STEQGQDTEVKASDPHSMPELPRTAKQP------PVPPP 461
            L+    G S     TP E    + G +    AS P   P+    A  P      P PP 
Sbjct: 588 DLA----GHSSSATSTPEELRGYDSGPEGGAAASPP---PDAELAACHPAAWSRGPAPP- 639

Query: 462 RKKRISRQLASTLPAPLENAE-------LC----TQAMALETPTPGPPREGQSPASQAGT 510
               ++ + A   P P   A        LC    T+     TP PG    G SP +  G 
Sbjct: 640 ----LAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGK 695

Query: 511 QHPPAQATAHSQS 523
               A A A S+S
Sbjct: 696 AAAGAGAGASSRS 708



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 69/293 (23%), Positives = 101/293 (34%), Gaps = 42/293 (14%)

Query: 277 PRRPPPPPPVLP--LQPCSPA----QPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
           P  P PPPPV P  L+    A    + P+           +P S P   P  T   P   
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASG 89

Query: 331 DHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPR-- 388
                PP       P  + G         +PG       ++ A    A+     AP R  
Sbjct: 90  RGERAPPAKNTSPGPVSSPGRA---SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 146

Query: 389 -----RRVSERVSLEDQSPGMA----AEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVK 439
                RR +   +    SP MA    A G ++ LP       P   PR  TE  + +   
Sbjct: 147 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP----RPAPSARPRPPTEGPRKSVSS 202

Query: 440 ASDPHSMPELPRTAKQPPVPPPRKKRISRQLAS-----------------TLPAPLENAE 482
           AS+  +    P   ++P      ++  SR L+S                 T  AP   ++
Sbjct: 203 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 262

Query: 483 LCTQAM-ALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASL 534
              + + AL  P   PPR+  +PA    +  P A  +  +  SP    SL +L
Sbjct: 263 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL 315



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 68/279 (24%), Positives = 92/279 (32%), Gaps = 52/279 (18%)

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKP 361
           A AP    P P   P P P VTP A                       G  PL E A   
Sbjct: 19  ARAPGLLTPRPPGSPRPPPPVTPAALRVLG-------------AAGAVGRKPLAERAGGI 65

Query: 362 GAASSPLQQVPAPPL-----PAKKNLPTAPPRRRVSE-RVSLEDQSPGMAAEGDQLSLPP 415
           G A+ P     A P      PA      APP +  S   VS   ++ G    G      P
Sbjct: 66  GGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG------P 119

Query: 416 QGTSDGPEDTPRESTEQGQDTEV-KASDPHSMPELPRTAKQPPVPPPRKKRISRQLAST- 473
            G   G   +  E+  +G+ TE  K S   +      +   P  P P   R SR   +  
Sbjct: 120 LG-QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEV 178

Query: 474 -LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLA 532
            LP P  +A             P PP EG   +  + ++H   + +  ++  P       
Sbjct: 179 GLPRPAPSAR------------PRPPTEGPRKSVSSASEHSTTEPSPAARRRP------- 219

Query: 533 SLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKP 571
               S G  +      S S+S+T       S PS +  P
Sbjct: 220 ----SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP 254



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 38/160 (23%), Positives = 60/160 (37%), Gaps = 12/160 (7%)

Query: 424 DTPRESTEQGQDTEVKASDPHSM--PELPRTAKQPPVPPPRKKRISRQLASTLPAPL-EN 480
           D  R+  + G      A+    +  P  P + + PP   P   R+     +    PL E 
Sbjct: 2   DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61

Query: 481 AELCTQAMALET-PTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLG 539
           A     A   E+ P  GP R  + PAS  G + PPA+ T+    S   + S  +    LG
Sbjct: 62  AGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 121

Query: 540 VSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKAR 579
              +          S EE + +  +    K+ ++  G  R
Sbjct: 122 QKGLRI--------SAEETVARGKATEAPKRSALSAGARR 153


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 94/358 (26%), Positives = 132/358 (36%), Gaps = 60/358 (16%)

Query: 248 PTDQPPLGNCPARPLPPTSDATSPTSRWAPR-RPPPPPPVLPLQPCSPAQPPVLPALAPA 306
           PT  P   +     LP   DA+ P ++ A   R     P LP    SP++PP+       
Sbjct: 261 PTQTPQTDHAK---LPLQRDASRPQTKQADIVRGESVKPSLP----SPSKPPIQQ----- 308

Query: 307 PACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS 366
              P P  PP   P      PGP   P QP  +T              +  A +PG    
Sbjct: 309 ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLT--------------KPLAQQPGTVKP 351

Query: 367 PLQQVPAPPLPAKKNLPTAPPRRRV-SERVSLEDQSPGMAAEGDQLSLPPQ---GTSDGP 422
           P+Q       PA+   P  PP ++  SE+ S E   P   A+   +   P    G +  P
Sbjct: 352 PVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP 411

Query: 423 ED---TPRESTEQ-GQDTEVKASDPHSMP-ELPRTAKQPPVPPPRKKRISRQLAST---- 473
                TP+   +Q G  +  KA  P   P + P   K P       K  ++Q   T    
Sbjct: 412 TQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS 471

Query: 474 -LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLA 532
            LP P   A+   Q      P P  P   + P+ Q G+  PP Q    ++ SP+  GS  
Sbjct: 472 QLPGP---AKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTK 528

Query: 533 SLSDSLGVSVMATDQDSYSTSSTEEELEQFS-------------SPSVKKKPSMILGK 577
             S   G +  +  Q S +  S ++  +  S             SPS K+ PS  L K
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 76/314 (24%), Positives = 110/314 (35%), Gaps = 51/314 (16%)

Query: 258 PARPLPPTSDATSPTSRWAPR-RPPPPPPVL---PLQPCSPAQPPVLPALAPAPACPLPT 313
           PA+P    S  T P ++     +PP  PP     P QP  PA+PP     +  P+   P 
Sbjct: 328 PAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 387

Query: 314 SPPVPAP----HVTPHAPGPPDHPNQ-----PPMMTCERLPCPTAGLGPLREEAMKPGAA 364
              +  P          PGP   P Q      P+     L  P    GP +    +PG  
Sbjct: 388 PKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPG 447

Query: 365 SSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPED 424
             P QQ       A++  PT PP            Q PG A        PPQ    GP  
Sbjct: 448 KIPAQQAGPGKTSAQQTGPTKPP-----------SQLPGPAKP------PPQ--QPGPAK 488

Query: 425 TPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELC 484
            P +     +    +       P+ P  AK  P  P   K  S+Q  S  P         
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP--------- 539

Query: 485 TQAMALETPTPGPPREGQS--PASQAGT----QHPPAQATAHSQSSPEFKGSLASLSDSL 538
               + + P+P  P   QS  P SQ G+    Q P    +A    S     ++  L ++ 
Sbjct: 540 ----SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTT 595

Query: 539 GVSVMATDQDSYST 552
            + +   ++ +++T
Sbjct: 596 ELLLHVPEKANFNT 609



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 93/363 (25%), Positives = 128/363 (35%), Gaps = 91/363 (25%)

Query: 244  SSALPTDQP-PLGNCPARPLPPTSDATSPTSRWAPRRPPP--PPPVLPLQPCSPA-QPPV 299
            +SA+    P P    P +   P  D +       P++PPP    P L   P + A QPP 
Sbjct: 669  TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPE---PKKPPPLVKQPTLHGSPSAKAKQPPE 725

Query: 300  LPALA-PAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEA 358
              +L+ PAP    P  P VP+      AP   D P QP M+       PT  L       
Sbjct: 726  ADSLSKPAP----PKEPSVPSEQ--DKAPVADDKPKQPKMVK------PTTDLVSSSSAT 773

Query: 359  MKPGAASSPLQ----QVPAPPLPAKKNLPTA--PPRRRVSERVSLEDQS--PGMAAEGDQ 410
             KP   SS +Q    +   PPL      P+   PP     E+VS  D    P  A++   
Sbjct: 774  TKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPP---TGEKVSPFDSKAIPRPASDSKI 830

Query: 411  LSLP-PQGTSDGPEDT-PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPP------- 461
            +S P P   S G +   P +  E+ +  + K S       +P+ +  PP P P       
Sbjct: 831  ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890

Query: 462  ----------RKKRISRQLASTLPAPLEN----------------AELCTQAMAL----- 490
                      + +R S  L S   AP                   A + +QA  L     
Sbjct: 891  TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950

Query: 491  ---------------ETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLS 535
                           + P P  P   Q P    G Q PPA A    +S P  K + A  +
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTG-QAPPAPA----KSIPVKKETKAPAA 1005

Query: 536  DSL 538
            + L
Sbjct: 1006 EKL 1008



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 98/406 (24%), Positives = 140/406 (34%), Gaps = 53/406 (13%)

Query: 186 PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
           PPQ+ G PA+PP  + PG     S +P +             G  +     P   +  S+
Sbjct: 480 PPQQPG-PAKPPPQQ-PG-----SAKPPSQQPGSTKPPPQQPGPAK-----PSPQQPGST 527

Query: 246 ALPTDQP----PLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLP 301
             P+ QP    P    P+   P    +T P S+    +P  PP V P    S  QPP   
Sbjct: 528 KPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSP----SAKQPP--S 581

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGP-------- 353
              P   CPL  +  +   HV       P+  N      C+   C   G  P        
Sbjct: 582 QGLPKTICPLCNTTEL-LLHV-------PEKANFNTCTECQTTVCSLCGFNPNPHLTEVK 633

Query: 354 --LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGM-AAEGDQ 410
             L        A    L  VP+ P P  K  P              +  SP   AA    
Sbjct: 634 EWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQD 693

Query: 411 LSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISR 468
           LS  P+     P    ++ T  G  +  KA  P     L  P   K+P VP  + K    
Sbjct: 694 LSKAPEPKK--PPPLVKQPTLHGSPS-AKAKQPPEADSLSKPAPPKEPSVPSEQDK---A 747

Query: 469 QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEF- 527
            +A   P   +  +  T  ++  + T  P        SQA  +  P   T  ++ S  F 
Sbjct: 748 PVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFP 807

Query: 528 -KGSLASLSDSLGVSVMATDQD--SYSTSSTEEELEQFSSPSVKKK 570
             G   S  DS  +   A+D    S+   S+E + ++   P  KK+
Sbjct: 808 PTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 41/156 (26%), Positives = 60/156 (38%), Gaps = 15/156 (9%)

Query: 241  EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL 300
            E  +S LP+  P + + PA+P P    ++   S   P  PPPPPP  P  P  P  PP+ 
Sbjct: 2370 EKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPP-PPPPPPPPPPPLP 2428

Query: 301  PALAPAP----------ACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAG 350
            P  +P P          A P+ T+ P+     T            P    C   P P   
Sbjct: 2429 PPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPV-- 2486

Query: 351  LGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAP 386
              P +  ++  G   +   +   PP+  K  +P  P
Sbjct: 2487 --PPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 53/219 (24%), Positives = 78/219 (35%), Gaps = 18/219 (8%)

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSP-GMAAEGDQLSL 413
           +E+    G    PLQQ P  P+P K+  P   P ++     S+  Q P  + ++      
Sbjct: 198 KEQGKPEGIIKPPLQQQPPKPIP-KQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGK 256

Query: 414 PPQGTSDGPE----------DTPRESTEQ-----GQDTEVKASDPHSMPELPRTAKQPPV 458
           P QG +  P+          D  R  T+Q     G+  +     P   P    T  +PP 
Sbjct: 257 PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPA 316

Query: 459 PPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQAT 518
             P  ++     A     P    +   Q      P   PP   + PA   G   PPAQ T
Sbjct: 317 QQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQT 376

Query: 519 AHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEE 557
              + S E  G  A L+   GV      Q   +   T++
Sbjct: 377 GSEKPSSEQPGPKA-LAQPPGVGKTPAQQPGPAKPPTQQ 414



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 65/273 (23%), Positives = 87/273 (31%), Gaps = 49/273 (17%)

Query: 244  SSALPTDQPPLGNCPARP---LPPTSDATSP-TSRWAPR---------RPPPPPPVLPLQ 290
            S A     PPL    A+P    PPT +  SP  S+  PR          P P       +
Sbjct: 785  SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844

Query: 291  PCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAG 350
               P Q    P  A     P P + P+P    TP  PGP                 PTAG
Sbjct: 845  QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTP--PGPR----------------PTAG 886

Query: 351  -LGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSE----RVSLEDQSPGMA 405
               P  +++ KP   S            A K+ PT P      +      S+  Q+  + 
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 406  AEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP---PR 462
            +   Q   P   +  GP    +++    Q        P S      T + PP P    P 
Sbjct: 947  STAGQ---PGPHSQSGPGAPMKQAPAPSQ-------PPTSQGPPKSTGQAPPAPAKSIPV 996

Query: 463  KKRISRQLASTLPAPLENAELCTQAMALETPTP 495
            KK      A  L    E A    +    + P P
Sbjct: 997  KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPP 1029



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 53/203 (26%), Positives = 75/203 (36%), Gaps = 22/203 (10%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
            PP     P  PP    P  P  +S +PT          +L+V +  +    P+F  D  +
Sbjct: 2409 PPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK-----KLTVASP-VTTATPLF--DAVT 2460

Query: 246  ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQP-PVLPALA 304
             L T      N     LP T   T+     AP   PP P  +P       +P P  P +A
Sbjct: 2461 TLETTAVLRSN----GLPVTRICTT-----APPPVPPKPSSIPSGLVFTHRPEPSKPPIA 2511

Query: 305  PAPACP-LPTSPPVPAP-HVTPHAPGPPDHPNQPPMMTCE-RLPCPTAGLGPLREEAMKP 361
            P P  P LPT+   P   H  P             + + + +LP PT+ L P       P
Sbjct: 2512 PKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSP-HSNKSSP 2570

Query: 362  GAASSPLQQVPAPPLPAKKNLPT 384
              + S  +      LP++   PT
Sbjct: 2571 RFSKSLTETYVVITLPSEPGTPT 2593



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 44/184 (23%), Positives = 64/184 (34%), Gaps = 39/184 (21%)

Query: 245  SALPTDQPPLGNCPARPLP-PTSDATSPTSRWAPRRP----------------PPPPPVL 287
            S  P  +P     P  P P PT+  T PT + +P+                  P   P  
Sbjct: 863  SPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT 922

Query: 288  PLQPC------------SPAQPPVLPALAPAPACPLPTSPPV---PAPHVTPHAPGPPDH 332
            P +              S A   +  A  P P        P+   PAP   P + GPP  
Sbjct: 923  PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKS 982

Query: 333  PNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPL-----QQVPAPPLPAKKNLPTAPP 387
              Q P    + +P       P  E+ ++P A  +P       +   PP+   K+L TA P
Sbjct: 983  TGQAPPAPAKSIPVKKETKAPAAEK-LEPKAEQAPTVKRTETEKKPPPIKDSKSL-TAEP 1040

Query: 388  RRRV 391
            ++ V
Sbjct: 1041 QKAV 1044


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 94/358 (26%), Positives = 132/358 (36%), Gaps = 60/358 (16%)

Query: 248 PTDQPPLGNCPARPLPPTSDATSPTSRWAPR-RPPPPPPVLPLQPCSPAQPPVLPALAPA 306
           PT  P   +     LP   DA+ P ++ A   R     P LP    SP++PP+       
Sbjct: 261 PTQTPQTDHAK---LPLQRDASRPQTKQADIVRGESVKPSLP----SPSKPPIQQ----- 308

Query: 307 PACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS 366
              P P  PP   P      PGP   P QP  +T              +  A +PG    
Sbjct: 309 ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLT--------------KPLAQQPGTVKP 351

Query: 367 PLQQVPAPPLPAKKNLPTAPPRRRV-SERVSLEDQSPGMAAEGDQLSLPPQ---GTSDGP 422
           P+Q       PA+   P  PP ++  SE+ S E   P   A+   +   P    G +  P
Sbjct: 352 PVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP 411

Query: 423 ED---TPRESTEQ-GQDTEVKASDPHSMP-ELPRTAKQPPVPPPRKKRISRQLAST---- 473
                TP+   +Q G  +  KA  P   P + P   K P       K  ++Q   T    
Sbjct: 412 TQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS 471

Query: 474 -LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLA 532
            LP P   A+   Q      P P  P   + P+ Q G+  PP Q    ++ SP+  GS  
Sbjct: 472 QLPGP---AKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTK 528

Query: 533 SLSDSLGVSVMATDQDSYSTSSTEEELEQFS-------------SPSVKKKPSMILGK 577
             S   G +  +  Q S +  S ++  +  S             SPS K+ PS  L K
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 76/314 (24%), Positives = 110/314 (35%), Gaps = 51/314 (16%)

Query: 258 PARPLPPTSDATSPTSRWAPR-RPPPPPPVL---PLQPCSPAQPPVLPALAPAPACPLPT 313
           PA+P    S  T P ++     +PP  PP     P QP  PA+PP     +  P+   P 
Sbjct: 328 PAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 387

Query: 314 SPPVPAP----HVTPHAPGPPDHPNQ-----PPMMTCERLPCPTAGLGPLREEAMKPGAA 364
              +  P          PGP   P Q      P+     L  P    GP +    +PG  
Sbjct: 388 PKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPG 447

Query: 365 SSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPED 424
             P QQ       A++  PT PP            Q PG A        PPQ    GP  
Sbjct: 448 KIPAQQAGPGKTSAQQTGPTKPP-----------SQLPGPAKP------PPQ--QPGPAK 488

Query: 425 TPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELC 484
            P +     +    +       P+ P  AK  P  P   K  S+Q  S  P         
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP--------- 539

Query: 485 TQAMALETPTPGPPREGQS--PASQAGT----QHPPAQATAHSQSSPEFKGSLASLSDSL 538
               + + P+P  P   QS  P SQ G+    Q P    +A    S     ++  L ++ 
Sbjct: 540 ----SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTT 595

Query: 539 GVSVMATDQDSYST 552
            + +   ++ +++T
Sbjct: 596 ELLLHVPEKANFNT 609



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 93/363 (25%), Positives = 128/363 (35%), Gaps = 91/363 (25%)

Query: 244  SSALPTDQP-PLGNCPARPLPPTSDATSPTSRWAPRRPPP--PPPVLPLQPCSPA-QPPV 299
            +SA+    P P    P +   P  D +       P++PPP    P L   P + A QPP 
Sbjct: 669  TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPE---PKKPPPLVKQPTLHGSPSAKAKQPPE 725

Query: 300  LPALA-PAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEA 358
              +L+ PAP    P  P VP+      AP   D P QP M+       PT  L       
Sbjct: 726  ADSLSKPAP----PKEPSVPSEQ--DKAPVADDKPKQPKMVK------PTTDLVSSSSAT 773

Query: 359  MKPGAASSPLQ----QVPAPPLPAKKNLPTA--PPRRRVSERVSLEDQS--PGMAAEGDQ 410
             KP   SS +Q    +   PPL      P+   PP     E+VS  D    P  A++   
Sbjct: 774  TKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPP---TGEKVSPFDSKAIPRPASDSKI 830

Query: 411  LSLP-PQGTSDGPEDT-PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPP------- 461
            +S P P   S G +   P +  E+ +  + K S       +P+ +  PP P P       
Sbjct: 831  ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890

Query: 462  ----------RKKRISRQLASTLPAPLEN----------------AELCTQAMAL----- 490
                      + +R S  L S   AP                   A + +QA  L     
Sbjct: 891  TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950

Query: 491  ---------------ETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLS 535
                           + P P  P   Q P    G Q PPA A    +S P  K + A  +
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTG-QAPPAPA----KSIPVKKETKAPAA 1005

Query: 536  DSL 538
            + L
Sbjct: 1006 EKL 1008



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 98/406 (24%), Positives = 140/406 (34%), Gaps = 53/406 (13%)

Query: 186 PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
           PPQ+ G PA+PP  + PG     S +P +             G  +     P   +  S+
Sbjct: 480 PPQQPG-PAKPPPQQ-PG-----SAKPPSQQPGSTKPPPQQPGPAK-----PSPQQPGST 527

Query: 246 ALPTDQP----PLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLP 301
             P+ QP    P    P+   P    +T P S+    +P  PP V P    S  QPP   
Sbjct: 528 KPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSP----SAKQPP--S 581

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGP-------- 353
              P   CPL  +  +   HV       P+  N      C+   C   G  P        
Sbjct: 582 QGLPKTICPLCNTTEL-LLHV-------PEKANFNTCTECQTTVCSLCGFNPNPHLTEVK 633

Query: 354 --LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGM-AAEGDQ 410
             L        A    L  VP+ P P  K  P              +  SP   AA    
Sbjct: 634 EWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQD 693

Query: 411 LSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISR 468
           LS  P+     P    ++ T  G  +  KA  P     L  P   K+P VP  + K    
Sbjct: 694 LSKAPEPKK--PPPLVKQPTLHGSPS-AKAKQPPEADSLSKPAPPKEPSVPSEQDK---A 747

Query: 469 QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEF- 527
            +A   P   +  +  T  ++  + T  P        SQA  +  P   T  ++ S  F 
Sbjct: 748 PVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFP 807

Query: 528 -KGSLASLSDSLGVSVMATDQD--SYSTSSTEEELEQFSSPSVKKK 570
             G   S  DS  +   A+D    S+   S+E + ++   P  KK+
Sbjct: 808 PTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 41/156 (26%), Positives = 60/156 (38%), Gaps = 15/156 (9%)

Query: 241  EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL 300
            E  +S LP+  P + + PA+P P    ++   S   P  PPPPPP  P  P  P  PP+ 
Sbjct: 2370 EKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPP-PPPPPPPPPPPLP 2428

Query: 301  PALAPAP----------ACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAG 350
            P  +P P          A P+ T+ P+     T            P    C   P P   
Sbjct: 2429 PPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPV-- 2486

Query: 351  LGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAP 386
              P +  ++  G   +   +   PP+  K  +P  P
Sbjct: 2487 --PPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 53/219 (24%), Positives = 78/219 (35%), Gaps = 18/219 (8%)

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSP-GMAAEGDQLSL 413
           +E+    G    PLQQ P  P+P K+  P   P ++     S+  Q P  + ++      
Sbjct: 198 KEQGKPEGIIKPPLQQQPPKPIP-KQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGK 256

Query: 414 PPQGTSDGPE----------DTPRESTEQ-----GQDTEVKASDPHSMPELPRTAKQPPV 458
           P QG +  P+          D  R  T+Q     G+  +     P   P    T  +PP 
Sbjct: 257 PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPA 316

Query: 459 PPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQAT 518
             P  ++     A     P    +   Q      P   PP   + PA   G   PPAQ T
Sbjct: 317 QQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQT 376

Query: 519 AHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEE 557
              + S E  G  A L+   GV      Q   +   T++
Sbjct: 377 GSEKPSSEQPGPKA-LAQPPGVGKTPAQQPGPAKPPTQQ 414



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 65/273 (23%), Positives = 87/273 (31%), Gaps = 49/273 (17%)

Query: 244  SSALPTDQPPLGNCPARP---LPPTSDATSP-TSRWAPR---------RPPPPPPVLPLQ 290
            S A     PPL    A+P    PPT +  SP  S+  PR          P P       +
Sbjct: 785  SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844

Query: 291  PCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAG 350
               P Q    P  A     P P + P+P    TP  PGP                 PTAG
Sbjct: 845  QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTP--PGPR----------------PTAG 886

Query: 351  -LGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSE----RVSLEDQSPGMA 405
               P  +++ KP   S            A K+ PT P      +      S+  Q+  + 
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 406  AEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP---PR 462
            +   Q   P   +  GP    +++    Q        P S      T + PP P    P 
Sbjct: 947  STAGQ---PGPHSQSGPGAPMKQAPAPSQ-------PPTSQGPPKSTGQAPPAPAKSIPV 996

Query: 463  KKRISRQLASTLPAPLENAELCTQAMALETPTP 495
            KK      A  L    E A    +    + P P
Sbjct: 997  KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPP 1029



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 53/203 (26%), Positives = 75/203 (36%), Gaps = 22/203 (10%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
            PP     P  PP    P  P  +S +PT          +L+V +  +    P+F  D  +
Sbjct: 2409 PPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKK-----KLTVASP-VTTATPLF--DAVT 2460

Query: 246  ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQP-PVLPALA 304
             L T      N     LP T   T+     AP   PP P  +P       +P P  P +A
Sbjct: 2461 TLETTAVLRSN----GLPVTRICTT-----APPPVPPKPSSIPSGLVFTHRPEPSKPPIA 2511

Query: 305  PAPACP-LPTSPPVPAP-HVTPHAPGPPDHPNQPPMMTCE-RLPCPTAGLGPLREEAMKP 361
            P P  P LPT+   P   H  P             + + + +LP PT+ L P       P
Sbjct: 2512 PKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSP-HSNKSSP 2570

Query: 362  GAASSPLQQVPAPPLPAKKNLPT 384
              + S  +      LP++   PT
Sbjct: 2571 RFSKSLTETYVVITLPSEPGTPT 2593



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 44/184 (23%), Positives = 64/184 (34%), Gaps = 39/184 (21%)

Query: 245  SALPTDQPPLGNCPARPLP-PTSDATSPTSRWAPRRP----------------PPPPPVL 287
            S  P  +P     P  P P PT+  T PT + +P+                  P   P  
Sbjct: 863  SPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT 922

Query: 288  PLQPC------------SPAQPPVLPALAPAPACPLPTSPPV---PAPHVTPHAPGPPDH 332
            P +              S A   +  A  P P        P+   PAP   P + GPP  
Sbjct: 923  PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKS 982

Query: 333  PNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPL-----QQVPAPPLPAKKNLPTAPP 387
              Q P    + +P       P  E+ ++P A  +P       +   PP+   K+L TA P
Sbjct: 983  TGQAPPAPAKSIPVKKETKAPAAEK-LEPKAEQAPTVKRTETEKKPPPIKDSKSL-TAEP 1040

Query: 388  RRRV 391
            ++ V
Sbjct: 1041 QKAV 1044


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 99/377 (26%), Positives = 137/377 (36%), Gaps = 61/377 (16%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
            PP  +G PA PP   AP  P  +   P +     A        N  +  V P        
Sbjct: 1248 PPSPKGGPATPPPKGAPTPPAAT---PPSLKGGLATPPHKGAPNPAV--VTP----PSPK 1298

Query: 246  ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLP--LQPCSPAQPPVLPAL 303
              P   PP G     P PP   AT P+ + +P  PPP     P  + P SP   P LPA 
Sbjct: 1299 GGPATSPPKG----APTPPA--ATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPAT 1352

Query: 304  APA----PACPL----PTSPPV------------PAPHVTPHAPGPPDHPNQPPMMTCER 343
             P+    P  P     PT P              P+P   P  P P   P  P ++    
Sbjct: 1353 TPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSP 1412

Query: 344  LPCPTAGLGPLREEAMKPG------AASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSL 397
               P   +   RE A  P        A +P+    AP   A K  P  P  +      ++
Sbjct: 1413 KKAPATPV--TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAV 1470

Query: 398  EDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDT--EVKASDPHSMPELPRTAKQ 455
               SP       Q++     TS  P+  P      G  T   V  S P  +P  P + + 
Sbjct: 1471 TPPSPKEPPAPKQVA-----TSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525

Query: 456  PPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETP--TPGPPREGQSPASQAGTQ-- 511
            P    P    +S++  +TL AP E   L   AM + +P  TP  P   ++PA+ +  +  
Sbjct: 1526 PIA--PTATLLSKKTPATL-APKE--ALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEAS 1580

Query: 512  HPPAQATAHSQSSPEFK 528
             PPA   +  + +P  K
Sbjct: 1581 SPPAVTPSTYKGAPSPK 1597



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 92/325 (28%), Positives = 112/325 (34%), Gaps = 54/325 (16%)

Query: 247  LPTDQPPLGNCPARPLPPTSDATS-------PTSRWAPRRP---PPPPPVLPLQPCSPAQ 296
            +P    P G     P PP +   S       P+ +WAP  P   PP P   P  P SP  
Sbjct: 930  IPASPSPKG----APTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATP-SPKG 984

Query: 297  PPVLPALAP-----APACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGL 351
             P  PA  P      PA P P   P P P VTP  P P   P   P       P      
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPTP-PAVTP--PSPKGSPAATPFPKGASTPPAATPP 1041

Query: 352  GPLREEAMKP---GAASSPLQQVPA----PPLPAKKNLPTAPPRRRVSERVSLEDQSPGM 404
             P    A  P   GA ++P   +P+    P  P+ K  PT P     S +      SP  
Sbjct: 1042 SPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG 1101

Query: 405  AAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL--------PRT-AKQ 455
            A       +PP  T   P+        +G  T   A+ P     L        P T A  
Sbjct: 1102 A------PMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1155

Query: 456  PPVP-----PPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGT 510
            PP P      P  K      A+T P+P       +   A  TP   PP    SP     T
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP----SPKGGLAT 1211

Query: 511  QHPPAQATAHSQSSPEFKGSLASLS 535
              P    T  + + P  KG LA+ S
Sbjct: 1212 PSPKGAPTTPAATPPSPKGGLATPS 1236



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 95/362 (26%), Positives = 123/362 (33%), Gaps = 42/362 (11%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
            PP  +G PA P    AP  P  +   P    A           + +     P        
Sbjct: 947  PPSPKGGPATPSPKWAPTPPAATPPSPKGGPA---------TPSPKGAPTPPAATPPSPK 997

Query: 246  ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQP-CSPAQPPVLPALA 304
              P    P G      + P S   SP +   P+    PP   P  P  SPA  P+     
Sbjct: 998  GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAP 1057

Query: 305  PAPACPLPTSPPVPA-PHV----TPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAM 359
              PA  LP+    PA P +    TP A  PP     P   + +  P P A   P    + 
Sbjct: 1058 TTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPP----SP 1113

Query: 360  KPGAASSPLQQVPAPPL---PAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQ 416
            K G A+ P +  P  P    P+ K     PP +      +    SP    +G   + PP+
Sbjct: 1114 KGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP----KGGLATPPPK 1169

Query: 417  GTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-----PPRKKRISRQLA 471
            G    P  TP  S + G  T      P   P  P  A  PP P      P  K      A
Sbjct: 1170 GAPTTPAATP-PSPKGGLAT----PSPKGAPTTP--AATPPSPKGGLATPSPKGAPTTPA 1222

Query: 472  STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSL 531
            +T P+P       +   A  TP   PP    SP     T  P    T  + + P  KG L
Sbjct: 1223 ATPPSPKGGLATPSPKGAPTTPAATPP----SPKGGPATPPPKGAPTPPAATPPSLKGGL 1278

Query: 532  AS 533
            A+
Sbjct: 1279 AT 1280



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 85/310 (27%), Positives = 107/310 (34%), Gaps = 33/310 (10%)

Query: 245  SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPP-PVLPLQPCSPAQPPVLPAL 303
            SA+    P     P +  P  S    P  +  P  P P   P L +   SP +    PA 
Sbjct: 868  SAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAP 927

Query: 304  APAPACPLPTSPPVPAPHVTPHAP--GP-PDHPNQPPMMTCERLPCPTAG-LGPLREEAM 359
               PA P P   P P P  TP +P  GP    P   P       P P  G   P  + A 
Sbjct: 928  KGIPASPSPKGAPTP-PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAP 986

Query: 360  KPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTS 419
             P AA+ P  +   P  P+ K  PT P     S +      SP         S PP  T 
Sbjct: 987  TPPAATPPSPK-GGPATPSPKGAPTPPAVTPPSPK-----GSPAATPFPKGASTPPAATP 1040

Query: 420  DGPEDTPRES-TEQGQDTEVKAS--DPHSMPELPRTAKQPPVPP-------------PRK 463
              P+ +P  +   +G  T   A+   P   P  P + K  P PP             P  
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP-SLKGAPTPPAATPPSPKGGPATPSP 1099

Query: 464  KRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQS 523
            K      A+T P+P           A  TP   PP    SP     T  P    T  + +
Sbjct: 1100 KGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP----SPKGGLATPPPKGAPTTPAAT 1155

Query: 524  SPEFKGSLAS 533
             P  KG LA+
Sbjct: 1156 PPSPKGGLAT 1165



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 94/392 (23%), Positives = 122/392 (31%), Gaps = 61/392 (15%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSS 245
            PP  +G  A PP   AP  P  +   P            L+    +     P        
Sbjct: 1110 PPSPKGGLATPPHKGAPTTPAATPPSPKGG---------LATPPPKGAPTTPAATPPSPK 1160

Query: 246  ALPTDQPPLG---NCPARPLPPTSDATSPTSRWAPRRPP--PPPPVLPLQPCSPAQPPVL 300
                  PP G      A P  P     +P+ + AP  P   PP P   L   SP   P  
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 301  PALAP--------------APACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPC 346
            PA  P              AP  P  T P       TP   G P  P   P      L  
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT 1280

Query: 347  PTAGLGP----LREEAMKPGAASSPLQQVPAPPL---PAKKNLPTAPPRRRVSERVSLED 399
            P     P    +   + K G A+SP +  P PP    P+ K  P  PP +      ++  
Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP 1340

Query: 400  QSP----------------GMAAEGDQLSLPPQGT---SDGPEDTPRESTEQGQDTEVKA 440
             SP                       +   PP  T     GP  TP  S ++G       
Sbjct: 1341 PSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTP-PSPKRGPAIPSPK 1399

Query: 441  SDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGP--P 498
             DP S   +P + K+ P  P  ++  +      L  P        +A A   P  GP  P
Sbjct: 1400 GDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATP 1459

Query: 499  REGQSPASQAGT----QHPPAQATAHSQSSPE 526
                 P   A T    + PPA     + SSP+
Sbjct: 1460 SSKGDPTLPAVTPPSPKEPPAPKQVATSSSPK 1491



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 103/405 (25%), Positives = 139/405 (34%), Gaps = 74/405 (18%)

Query: 187  PQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCA-----CEIELSVGNDRLWFVNPI-FI 240
            P+    P+ PP    PG   V  +  T+  A  A     C  E S  +        + ++
Sbjct: 731  PKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYL 790

Query: 241  EDCSSAL------PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSP 294
             D  S L       T +PP     A P  P  + +SP S       P     LP    S 
Sbjct: 791  ADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVS-------PVEASFLPENSLSF 843

Query: 295  AQPPVLPALAPAPACPLPTSPPVPAPHVTPHAP-GPPDHPNQPPMMTCERLPCPTAG-LG 352
                  PA   +P  P P   P P+  VTP +P G    P + P  +   LP P  G   
Sbjct: 844  QGSKDSPATTHSPTPPSPKGAPTPSA-VTPLSPKGVTLPPKETPTPSVVNLPFPKEGPAT 902

Query: 353  PLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSP--GMAAEGDQ 410
            P  ++A      SS  ++  A P P  K +P +P  +      +    SP  G A    +
Sbjct: 903  PAPKQAPALSMTSSSPKKARATPAP--KGIPASPSPKGAPTPPAATPPSPKGGPATPSPK 960

Query: 411  LS-LPPQGTSDGPEDTPRESTEQGQDTEVKASDPH----SMPELPRTAKQPP-VPPPRKK 464
             +  PP  T   P+  P   + +G  T   A+ P          P+ A  PP V PP  K
Sbjct: 961  WAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPK 1020

Query: 465  RISRQL-----ASTLPA-------------PLENAELCTQAMALETPTPGP--------- 497
                       AST PA             PL      T A  L +P  GP         
Sbjct: 1021 GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAP 1080

Query: 498  ---------PREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLAS 533
                     P+ G +  S  G   PPA       + P  KG LA+
Sbjct: 1081 TPPAATPPSPKGGPATPSPKGAPMPPA------ATPPSPKGGLAT 1119



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 51/376 (13%)

Query: 190  RGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVN-PIFIEDCSSALP 248
            +G PA P     P  P V+   P+  +     ++  S    +      P+      + +P
Sbjct: 1453 KGGPATPSSKGDPTLPAVTP--PSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIP 1510

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLP--LQPCSPAQPPVLPALAPA 306
            +    +   P+    P +   +  S+  P    P   ++P  +   SP + P +P    A
Sbjct: 1511 SSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEA 1570

Query: 307  PACPLP---TSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGA 363
            PA P     +SPP   P     AP P            + L  P A   P  +EA  P A
Sbjct: 1571 PATPSSKEASSPPAVTPSTYKGAPSP------------KELLIPPAVTSPSPKEAPTPPA 1618

Query: 364  ASSPLQQVPAPPLPAKKNLPTAPPRRRVSER--------------VSLEDQSPGMAAEGD 409
             + P  +   P  PA K  PT+PP    S +               ++   S G+ A+  
Sbjct: 1619 VTPPSPE-KGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKG 1677

Query: 410  QLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPV-PPPRKKRISR 468
              +L     +  PE TP  +    +  + K S          +A  PP+ P P  K  S+
Sbjct: 1678 PTALKEVLVAPAPESTPIITAPTRKGPQTKKS----------SATSPPICPDPSAKNGSK 1727

Query: 469  -QLASTLPAPLENAELCTQAMALETPTPGPPREGQS-PASQAGTQHPPAQATAHSQSSPE 526
              L++  PAPL   +  +   A        P+   + P S+A T   P  A A  +  P+
Sbjct: 1728 GPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKAST---PLTAAAFEKVLPK 1784

Query: 527  FKGSLASLSDSLGVSV 542
             + +  S + S  VS+
Sbjct: 1785 PESASVSAAPSPPVSL 1800



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 66/274 (24%), Positives = 104/274 (37%), Gaps = 57/274 (20%)

Query: 262  LPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPH 321
            +PP   + S      P+  P PP V P            P+    PA P P   P  +P 
Sbjct: 1601 IPPAVTSPS------PKEAPTPPAVTP------------PSPEKGPATPAPKGTPT-SPP 1641

Query: 322  VTPHAPGPPDHPNQPPMMTCE---RLPCPTAGL----GP--LREEAMKPGAASSPLQQVP 372
            VTP +    D P  P  +TC+    +P  + GL    GP  L+E  + P   S+P+   P
Sbjct: 1642 VTPSS--LKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAP 1699

Query: 373  APPLP-AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTE 431
                P  KK+  T+PP           D S    ++G   ++ P       +D+ +  T 
Sbjct: 1700 TRKGPQTKKSSATSPP--------ICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSK--TA 1749

Query: 432  QGQDTEVKASDPHSMPE------LPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCT 485
            +G+D       P + PE      L   A +  +P P    +S   +  +  PL  + + T
Sbjct: 1750 KGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPT 1809

Query: 486  QAMALETPTPGPPREGQSPASQAGTQHPPAQATA 519
                       PP++   P+S       P++  A
Sbjct: 1810 L----------PPKQQFLPSSPGLVLESPSKPLA 1833



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 80/360 (22%), Positives = 122/360 (33%), Gaps = 41/360 (11%)

Query: 246  ALPTDQPPLGNCPARPLPPTSDA--TSPTSRWAPRRPPPPPPVLPLQPCSPAQPPV-LPA 302
            A+ +  P     P    PP+ +    +P  +  P  PP  P  L   P SPA     + A
Sbjct: 1604 AVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGA 1663

Query: 303  LAPAPACPLPTSPPVPAPHVTPHAPGPPDHP-NQPPMMTCERLPCPTAGLGPLREEAMKP 361
              P  +  LP      A      AP P   P    P     +    +A   P+  +    
Sbjct: 1664 TVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAK 1723

Query: 362  GAASSPLQQV-PAPPLPAKKNL---------------PTAPPRRRVSERVSLEDQSPGMA 405
              +  PL  V PAP LP +K+                P APP  + S        +P  A
Sbjct: 1724 NGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKAS--------TPLTA 1775

Query: 406  AEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHS--MPELPRTAKQPPVPPPRK 463
            A  +++   P+  S     +P  S      + V    P    +P  P    + P  P   
Sbjct: 1776 AAFEKVLPKPESASVSAAPSPPVSLPLA-PSPVPTLPPKQQFLPSSPGLVLESPSKPLAP 1834

Query: 464  KRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQS 523
                  L    P P+    +  Q++ +  PT   P+    P      + P  +    S +
Sbjct: 1835 ADEDELLPLIPPEPISGG-VPFQSVLVNMPT---PKSAGIPVPTPSAKQPVTKNNKGSGT 1890

Query: 524  SPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLS 583
              +   S+  L +    S  AT Q +   ++ E + E    P  K K S    KAR  +S
Sbjct: 1891 ESDSDESVPELEEQ--DSTQATTQQAQLAAAAEIDEE----PVSKAKQSRSEKKARKAMS 1944



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 76/301 (25%), Positives = 107/301 (35%), Gaps = 51/301 (16%)

Query: 264 PTSDATSPTSRWAPRRPPPPPPVLPL-QPC------------SPAQPPVLPALAPAP--- 307
           P S A S T+      P  PPP  P  Q C            SP+     P   P P   
Sbjct: 27  PMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSS 86

Query: 308 ---ACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAA 364
              A PL T+P   AP   P+  GPP  P    +     +  PT    P         ++
Sbjct: 87  SGTALPLGTAP--EAPTFLPNLIGPPISP--AALALASPMIAPTLKGTP---------SS 133

Query: 365 SSPLQQVPAPPLPAKK------NLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSL--PPQ 416
           S+PL  V   P   +K      NL T+PP   V+E  S+   S  +A    + +L   P 
Sbjct: 134 SAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPS 193

Query: 417 GTSDGPEDTPRE----STEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLAS 472
                P+ TP      ST         AS    +  LP+T     +     +     ++S
Sbjct: 194 EVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISS 253

Query: 473 TLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLA 532
            L +P     L  +        P  P    S ++Q+      +Q TA   + P+F  SL 
Sbjct: 254 VLISPQNPGSLSLKG-------PVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLG 306

Query: 533 S 533
           S
Sbjct: 307 S 307



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 98/414 (23%), Positives = 133/414 (32%), Gaps = 104/414 (25%)

Query: 206 LVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTD--------QPPLGNC 257
           L SS   T H    A     SVG   L   NP  I    +A PT          PP+ + 
Sbjct: 415 LKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTI----AAAPTTTFEVATCVSPPMSSG 470

Query: 258 PARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPV 317
           P   + PTS                 P  L + P +P +    P+   A    +P SPP+
Sbjct: 471 PISNIEPTS-----------------PAALVMAPVAPKE----PSTQVATTLRIPVSPPL 509

Query: 318 PAPHVTPHAPG------PPDHPNQPPMMTCERLPCPTAGLG----------PLREEAMKP 361
           P P    + P       P     Q    + E  P   A  G          PL + A K 
Sbjct: 510 PDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKN 569

Query: 362 GAASSPLQQVPAPPLP-----AKKNL------------PTAPPRRRVSERVSLEDQSPGM 404
             +       P  PL      AKK+L             T+P     S  V   D   G 
Sbjct: 570 SPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGP 629

Query: 405 AAEGDQLSLP---------PQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQ 455
            + G  L            P  ++D     P  +T +G  T    + P     +    K 
Sbjct: 630 DSAGPLLKSSLITPTVAAFPLESADPAGVAP--TTAKGTSTYTTTASPFLEGTVSLAPKN 687

Query: 456 PPVPPPRKKRI-----SRQLASTLPAPLEN-AELCTQAMALE----TPTPGPPREGQSPA 505
            PV       +     + +     P+P    A L T  +A E     P+P  P  G  P 
Sbjct: 688 HPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPG 747

Query: 506 SQA--GTQHPPAQATAHS------------QSSPEFKGSLASLSDS---LGVSV 542
           ++   G  H  A A   S             ++   KG+L  L+DS   LGVSV
Sbjct: 748 TKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSV 801


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 79/301 (26%), Positives = 105/301 (34%), Gaps = 25/301 (8%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTS-RWAPRRPPPPPPVLPLQ-PCSPAQPPVLPAL 303
           AL T + P    P  P   T    +PT+ + AP  P  P P      P +P +P      
Sbjct: 209 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 268

Query: 304 APAPACP---LPTSPPVPAPHVTPHAPGPPDHP----NQPPMMTCERLPCPTAGLGPLRE 356
            PAP  P    PT+   PAP  T  AP  P  P     + P  T  + P PT    P   
Sbjct: 269 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 328

Query: 357 EAMKPG-AASSPLQQVPAPPLPA--KKNLPT-----APPRRRVSERVSLEDQSPGMAAEG 408
              +P      P    P  P P   KK  PT     AP   +     + ++ SP    E 
Sbjct: 329 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 388

Query: 409 DQLSLPPQGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPE-LPRTAKQPPVPPPRKKR 465
                 P  T   P  T  P  +T +   T  K   P +  E  P T K+P    P+K  
Sbjct: 389 -----APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 443

Query: 466 ISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSP 525
            +         P E A   T+  A  TP    P   +  A     +  P      + ++P
Sbjct: 444 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 503

Query: 526 E 526
           E
Sbjct: 504 E 504



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/293 (25%), Positives = 104/293 (35%), Gaps = 20/293 (6%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALA 304
           SA  T + P    P +P P T    +PT+   P+ P P  P  P        P      A
Sbjct: 293 SAPTTPKEPAPTTPKKPAPTTPKEPAPTT---PKEPTPTTPKEPAPTTKEPAPTTPKEPA 349

Query: 305 P-APACPLPTSPPVPAPHVTPHAPGP-------PDHPNQPPMMTCERLPCPTAGLGP--L 354
           P AP  P PT+P  PAP  TP  P P       P  P +P   T +  P  T    P   
Sbjct: 350 PTAPKKPAPTTPKEPAP-TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 408

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLP 414
           +     P   S    + PAP  P K+  PT P +   +        +P   A        
Sbjct: 409 KSAPTTPKEPSPTTTKEPAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467

Query: 415 PQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-PPRKKRISRQLAST 473
           P    +    TP+E+      T  K   P +  +L  T  + P P  P +   +     T
Sbjct: 468 PTTPKEPAPTTPKETA----PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 523

Query: 474 LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P E A    +A A  TP    P   + PA     +  P      + ++P+
Sbjct: 524 PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 576



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 77/329 (23%), Positives = 119/329 (36%), Gaps = 22/329 (6%)

Query: 258 PARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPC--SPAQPPVLPALAPAPACPLPT 313
           P  P P T +  +PT+    AP  P  P P  P +P   +P +P        AP  P  T
Sbjct: 519 PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 578

Query: 314 SPPV---PAPHVTPHAPGP----PDHPNQPPMMTCERLPCPTA--GLGPLREEAMKPGAA 364
           +P     PAP  TP  P P    P    +P   TC++ P PT   G  P   +   P   
Sbjct: 579 APTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKEPAPTTP 636

Query: 365 SSPLQQVP--APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGP 422
             P    P    P   K+  PT P +    E      + P            P+ T+   
Sbjct: 637 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 696

Query: 423 EDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISRQL-ASTLPAPLE 479
              P  +T +        + P +  E+  P T K+P          + +L A   P  LE
Sbjct: 697 PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 756

Query: 480 NAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLG 539
           N+         +TP    P E  + A    T+         + ++P+     A+ ++   
Sbjct: 757 NSPKEPGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 815

Query: 540 VSVMATDQDSYSTSSTEEELEQFSSPSVK 568
            S + T   +  TS+T ++   F   ++K
Sbjct: 816 ESKI-TATTTQVTSTTTQDTTPFKITTLK 843



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 81/350 (23%), Positives = 122/350 (34%), Gaps = 42/350 (12%)

Query: 249 TDQPPLGNCPARPLPPTS--------DATSPTSRWAPRRPPPPPPVLPLQPC--SPAQPP 298
           T + P    P  P P T+        +    T++ AP  P  P P    +P   +P +P 
Sbjct: 376 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435

Query: 299 VLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
                 PAP  P    PT+P  PAP  T   P P       P    E  P     L P  
Sbjct: 436 PTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 494

Query: 356 EEAMKPGAASSPLQQVP---APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLS 412
            E + P     P    P   AP  P ++  PT P     +   +    +P   A      
Sbjct: 495 PEKLAPTTPEKPAPTTPEELAPTTP-EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 553

Query: 413 LPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQ-LA 471
             P    +    TP+E+      T  K + P ++ E   T  + P P       +++  +
Sbjct: 554 PAPTTPKEPAPTTPKETA----PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 609

Query: 472 STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQ----HPPAQATAHSQSSPEF 527
           +T   P       T     + P P  P+E  +P +  GT       PA  T    +  E 
Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKE-PAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 668

Query: 528 -----KGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPS 572
                KG  ++ SD        T +++  T+  E       +P+  KKP+
Sbjct: 669 APTTTKGPTSTTSDK---PAPTTPKETAPTTPKE------PAPTTPKKPA 709



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 75/292 (25%), Positives = 110/292 (37%), Gaps = 34/292 (11%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPCSPAQPPVLPA 302
           +A  T + P    P  P P T   T+PT+    AP  P  P P   L P +   P    +
Sbjct: 623 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGPTSTTS 681

Query: 303 LAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAM 359
             PAP  P    PT+P  PAP  TP  P P   P  PP  T E +  PT    P      
Sbjct: 682 DKPAPTTPKETAPTTPKEPAP-TTPKKPAPTT-PETPPPTTSE-VSTPTTTKEPTTIH-K 737

Query: 360 KPGAASSPLQQVPAPPLPAKKNLPTAP----PRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
            P  ++  L   P P   A +N P  P     +   + +  +   +     E D L   P
Sbjct: 738 SPDESTPELSAEPTP--KALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD-LRTTP 794

Query: 416 QGTSDGPEDTPRESTEQGQDTEVKA--------------SDPHSMPELPRTAKQPPVPPP 461
           + T+  P+ T   +T   + TE K               + P  +  L  T   P V   
Sbjct: 795 ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 854

Query: 462 RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHP 513
           +K   + ++   +  P E A+   +A   +  TP P +  ++P     T+ P
Sbjct: 855 KKTITTTEI---MNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 903



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 87/368 (23%), Positives = 126/368 (34%), Gaps = 55/368 (14%)

Query: 244 SSALPTDQPPLGNCPARPLPPTSDATSPTS--RWAP-----------RRPPPPPPVLP-- 288
           ++A  T + P    P  P P T    +PT+    AP           + P P  P  P  
Sbjct: 537 AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 596

Query: 289 --LQPCSPAQPPVLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCER 343
             L P +  +P       PAP  P    PT+P  PAP  TP  P P       P  T  +
Sbjct: 597 KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP-TTPKEPAPTTPKGTAP--TTLK 653

Query: 344 LPCPTAGLGPLREEAMKPGAASSPLQQV---PAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
            P PT    P  +E + P     P       PAP  P K+  PT P      E      +
Sbjct: 654 EPAPTTPKKPAPKE-LAPTTTKGPTSTTSDKPAPTTP-KETAPTTP-----KEPAPTTPK 706

Query: 401 SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPE---------LPR 451
            P           PP  TS+    TP   T   + T +  S   S PE         L  
Sbjct: 707 KPAPTTP----ETPPPTTSE--VSTP---TTTKEPTTIHKSPDESTPELSAEPTPKALEN 757

Query: 452 TAKQPPVPPPRKKRISR-QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGT 510
           + K+P VP  +    ++ ++ +T        +L T     ET T  P    ++  +   T
Sbjct: 758 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP---ETTTAAPKMTKETATTTEKT 814

Query: 511 QHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
                 AT    +S   + +      +L  + +A    +   + T  E+      + K K
Sbjct: 815 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 874

Query: 571 PSMILGKA 578
                 KA
Sbjct: 875 DRATNSKA 882



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 62/287 (21%), Positives = 98/287 (34%), Gaps = 48/287 (16%)

Query: 249 TDQPPLGNCPARPLPPTSDATSPTSRWAP----RRPPPPPPVLPLQPCSPAQPPVLPALA 304
           T + P    P  P P TS+ ++PT+   P    + P    P L  +P     P  L    
Sbjct: 704 TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP----TPKALENSP 759

Query: 305 PAPACPLPTSPPVPAPHVTPHAPG---------PPDHPNQPPMMTCERLPCPTAGLGPLR 355
             P  P   +P    P +T  A            P+     P MT E     T      +
Sbjct: 760 KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKE-TATTTEKTTESK 818

Query: 356 EEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
             A      S+  Q      +   K    AP      + ++  +                
Sbjct: 819 ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE---------------- 862

Query: 416 QGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP----PRKKRISRQ 469
               + PE+T  P++     + T  K   P   P+ P + K+P   P    P+     R+
Sbjct: 863 --IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRK 920

Query: 470 LASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQ 516
           + ST+P  L       +AM L+T T    R  Q+P S+    +P ++
Sbjct: 921 MTSTMP-ELNPTSRIAEAM-LQTTT----RPNQTPNSKLVEVNPKSE 961



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 27/144 (18%), Positives = 46/144 (31%), Gaps = 7/144 (4%)

Query: 378 AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTE 437
           AK   PT+    + + +     + P +    +     P+  +      P  +T +   T 
Sbjct: 184 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT 243

Query: 438 VKASDPHSMPELPRTAKQP-------PVPPPRKKRISRQLASTLPAPLENAELCTQAMAL 490
            K   P +    P T K+P       P P   K+          P   ++A    +  A 
Sbjct: 244 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 303

Query: 491 ETPTPGPPREGQSPASQAGTQHPP 514
            TP    P   + PA     +  P
Sbjct: 304 TTPKKPAPTTPKEPAPTTPKEPTP 327


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 79/301 (26%), Positives = 105/301 (34%), Gaps = 25/301 (8%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTS-RWAPRRPPPPPPVLPLQ-PCSPAQPPVLPAL 303
           AL T + P    P  P   T    +PT+ + AP  P  P P      P +P +P      
Sbjct: 250 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 309

Query: 304 APAPACP---LPTSPPVPAPHVTPHAPGPPDHP----NQPPMMTCERLPCPTAGLGPLRE 356
            PAP  P    PT+   PAP  T  AP  P  P     + P  T  + P PT    P   
Sbjct: 310 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 369

Query: 357 EAMKPG-AASSPLQQVPAPPLPA--KKNLPT-----APPRRRVSERVSLEDQSPGMAAEG 408
              +P      P    P  P P   KK  PT     AP   +     + ++ SP    E 
Sbjct: 370 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 429

Query: 409 DQLSLPPQGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPE-LPRTAKQPPVPPPRKKR 465
                 P  T   P  T  P  +T +   T  K   P +  E  P T K+P    P+K  
Sbjct: 430 -----APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 484

Query: 466 ISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSP 525
            +         P E A   T+  A  TP    P   +  A     +  P      + ++P
Sbjct: 485 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 544

Query: 526 E 526
           E
Sbjct: 545 E 545



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/293 (25%), Positives = 104/293 (35%), Gaps = 20/293 (6%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALA 304
           SA  T + P    P +P P T    +PT+   P+ P P  P  P        P      A
Sbjct: 334 SAPTTPKEPAPTTPKKPAPTTPKEPAPTT---PKEPTPTTPKEPAPTTKEPAPTTPKEPA 390

Query: 305 P-APACPLPTSPPVPAPHVTPHAPGP-------PDHPNQPPMMTCERLPCPTAGLGP--L 354
           P AP  P PT+P  PAP  TP  P P       P  P +P   T +  P  T    P   
Sbjct: 391 PTAPKKPAPTTPKEPAP-TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 449

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLP 414
           +     P   S    + PAP  P K+  PT P +   +        +P   A        
Sbjct: 450 KSAPTTPKEPSPTTTKEPAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508

Query: 415 PQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-PPRKKRISRQLAST 473
           P    +    TP+E+      T  K   P +  +L  T  + P P  P +   +     T
Sbjct: 509 PTTPKEPAPTTPKETA----PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 564

Query: 474 LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P E A    +A A  TP    P   + PA     +  P      + ++P+
Sbjct: 565 PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 617



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 77/329 (23%), Positives = 119/329 (36%), Gaps = 22/329 (6%)

Query: 258 PARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPC--SPAQPPVLPALAPAPACPLPT 313
           P  P P T +  +PT+    AP  P  P P  P +P   +P +P        AP  P  T
Sbjct: 560 PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 619

Query: 314 SPPV---PAPHVTPHAPGP----PDHPNQPPMMTCERLPCPTA--GLGPLREEAMKPGAA 364
           +P     PAP  TP  P P    P    +P   TC++ P PT   G  P   +   P   
Sbjct: 620 APTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKEPAPTTP 677

Query: 365 SSPLQQVP--APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGP 422
             P    P    P   K+  PT P +    E      + P            P+ T+   
Sbjct: 678 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 737

Query: 423 EDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISRQL-ASTLPAPLE 479
              P  +T +        + P +  E+  P T K+P          + +L A   P  LE
Sbjct: 738 PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 797

Query: 480 NAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLG 539
           N+         +TP    P E  + A    T+         + ++P+     A+ ++   
Sbjct: 798 NSPKEPGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 856

Query: 540 VSVMATDQDSYSTSSTEEELEQFSSPSVK 568
            S + T   +  TS+T ++   F   ++K
Sbjct: 857 ESKI-TATTTQVTSTTTQDTTPFKITTLK 884



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 81/350 (23%), Positives = 122/350 (34%), Gaps = 42/350 (12%)

Query: 249 TDQPPLGNCPARPLPPTS--------DATSPTSRWAPRRPPPPPPVLPLQPC--SPAQPP 298
           T + P    P  P P T+        +    T++ AP  P  P P    +P   +P +P 
Sbjct: 417 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476

Query: 299 VLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
                 PAP  P    PT+P  PAP  T   P P       P    E  P     L P  
Sbjct: 477 PTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 535

Query: 356 EEAMKPGAASSPLQQVP---APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLS 412
            E + P     P    P   AP  P ++  PT P     +   +    +P   A      
Sbjct: 536 PEKLAPTTPEKPAPTTPEELAPTTP-EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 594

Query: 413 LPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQ-LA 471
             P    +    TP+E+      T  K + P ++ E   T  + P P       +++  +
Sbjct: 595 PAPTTPKEPAPTTPKETA----PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 650

Query: 472 STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQ----HPPAQATAHSQSSPEF 527
           +T   P       T     + P P  P+E  +P +  GT       PA  T    +  E 
Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKE-PAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 709

Query: 528 -----KGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPS 572
                KG  ++ SD        T +++  T+  E       +P+  KKP+
Sbjct: 710 APTTTKGPTSTTSDK---PAPTTPKETAPTTPKE------PAPTTPKKPA 750



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 75/292 (25%), Positives = 110/292 (37%), Gaps = 34/292 (11%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPCSPAQPPVLPA 302
           +A  T + P    P  P P T   T+PT+    AP  P  P P   L P +   P    +
Sbjct: 664 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGPTSTTS 722

Query: 303 LAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAM 359
             PAP  P    PT+P  PAP  TP  P P   P  PP  T E +  PT    P      
Sbjct: 723 DKPAPTTPKETAPTTPKEPAP-TTPKKPAPTT-PETPPPTTSE-VSTPTTTKEPTTIH-K 778

Query: 360 KPGAASSPLQQVPAPPLPAKKNLPTAP----PRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
            P  ++  L   P P   A +N P  P     +   + +  +   +     E D L   P
Sbjct: 779 SPDESTPELSAEPTP--KALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD-LRTTP 835

Query: 416 QGTSDGPEDTPRESTEQGQDTEVKA--------------SDPHSMPELPRTAKQPPVPPP 461
           + T+  P+ T   +T   + TE K               + P  +  L  T   P V   
Sbjct: 836 ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 895

Query: 462 RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHP 513
           +K   + ++   +  P E A+   +A   +  TP P +  ++P     T+ P
Sbjct: 896 KKTITTTEI---MNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 944



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 87/368 (23%), Positives = 126/368 (34%), Gaps = 55/368 (14%)

Query: 244 SSALPTDQPPLGNCPARPLPPTSDATSPTS--RWAP-----------RRPPPPPPVLP-- 288
           ++A  T + P    P  P P T    +PT+    AP           + P P  P  P  
Sbjct: 578 AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 637

Query: 289 --LQPCSPAQPPVLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCER 343
             L P +  +P       PAP  P    PT+P  PAP  TP  P P       P  T  +
Sbjct: 638 KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP-TTPKEPAPTTPKGTAP--TTLK 694

Query: 344 LPCPTAGLGPLREEAMKPGAASSPLQQV---PAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
            P PT    P  +E + P     P       PAP  P K+  PT P      E      +
Sbjct: 695 EPAPTTPKKPAPKE-LAPTTTKGPTSTTSDKPAPTTP-KETAPTTP-----KEPAPTTPK 747

Query: 401 SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPE---------LPR 451
            P           PP  TS+    TP   T   + T +  S   S PE         L  
Sbjct: 748 KPAPTTP----ETPPPTTSE--VSTP---TTTKEPTTIHKSPDESTPELSAEPTPKALEN 798

Query: 452 TAKQPPVPPPRKKRISR-QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGT 510
           + K+P VP  +    ++ ++ +T        +L T     ET T  P    ++  +   T
Sbjct: 799 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP---ETTTAAPKMTKETATTTEKT 855

Query: 511 QHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
                 AT    +S   + +      +L  + +A    +   + T  E+      + K K
Sbjct: 856 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 915

Query: 571 PSMILGKA 578
                 KA
Sbjct: 916 DRATNSKA 923



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 62/287 (21%), Positives = 98/287 (34%), Gaps = 48/287 (16%)

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWAP----RRPPPPPPVLPLQPCSPAQPPVLPALA 304
            T + P    P  P P TS+ ++PT+   P    + P    P L  +P     P  L    
Sbjct: 745  TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP----TPKALENSP 800

Query: 305  PAPACPLPTSPPVPAPHVTPHAPG---------PPDHPNQPPMMTCERLPCPTAGLGPLR 355
              P  P   +P    P +T  A            P+     P MT E     T      +
Sbjct: 801  KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKE-TATTTEKTTESK 859

Query: 356  EEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
              A      S+  Q      +   K    AP      + ++  +                
Sbjct: 860  ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE---------------- 903

Query: 416  QGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP----PRKKRISRQ 469
                + PE+T  P++     + T  K   P   P+ P + K+P   P    P+     R+
Sbjct: 904  --IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRK 961

Query: 470  LASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQ 516
            + ST+P  L       +AM L+T T    R  Q+P S+    +P ++
Sbjct: 962  MTSTMP-ELNPTSRIAEAM-LQTTT----RPNQTPNSKLVEVNPKSE 1002



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 27/144 (18%), Positives = 46/144 (31%), Gaps = 7/144 (4%)

Query: 378 AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTE 437
           AK   PT+    + + +     + P +    +     P+  +      P  +T +   T 
Sbjct: 225 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT 284

Query: 438 VKASDPHSMPELPRTAKQP-------PVPPPRKKRISRQLASTLPAPLENAELCTQAMAL 490
            K   P +    P T K+P       P P   K+          P   ++A    +  A 
Sbjct: 285 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 344

Query: 491 ETPTPGPPREGQSPASQAGTQHPP 514
            TP    P   + PA     +  P
Sbjct: 345 TTPKKPAPTTPKEPAPTTPKEPTP 368


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 79/301 (26%), Positives = 105/301 (34%), Gaps = 25/301 (8%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTS-RWAPRRPPPPPPVLPLQ-PCSPAQPPVLPAL 303
           AL T + P    P  P   T    +PT+ + AP  P  P P      P +P +P      
Sbjct: 302 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 361

Query: 304 APAPACP---LPTSPPVPAPHVTPHAPGPPDHP----NQPPMMTCERLPCPTAGLGPLRE 356
            PAP  P    PT+   PAP  T  AP  P  P     + P  T  + P PT    P   
Sbjct: 362 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 421

Query: 357 EAMKPG-AASSPLQQVPAPPLPA--KKNLPT-----APPRRRVSERVSLEDQSPGMAAEG 408
              +P      P    P  P P   KK  PT     AP   +     + ++ SP    E 
Sbjct: 422 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 481

Query: 409 DQLSLPPQGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPE-LPRTAKQPPVPPPRKKR 465
                 P  T   P  T  P  +T +   T  K   P +  E  P T K+P    P+K  
Sbjct: 482 -----APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 536

Query: 466 ISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSP 525
            +         P E A   T+  A  TP    P   +  A     +  P      + ++P
Sbjct: 537 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 596

Query: 526 E 526
           E
Sbjct: 597 E 597



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/293 (25%), Positives = 104/293 (35%), Gaps = 20/293 (6%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALA 304
           SA  T + P    P +P P T    +PT+   P+ P P  P  P        P      A
Sbjct: 386 SAPTTPKEPAPTTPKKPAPTTPKEPAPTT---PKEPTPTTPKEPAPTTKEPAPTTPKEPA 442

Query: 305 P-APACPLPTSPPVPAPHVTPHAPGP-------PDHPNQPPMMTCERLPCPTAGLGP--L 354
           P AP  P PT+P  PAP  TP  P P       P  P +P   T +  P  T    P   
Sbjct: 443 PTAPKKPAPTTPKEPAP-TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 501

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLP 414
           +     P   S    + PAP  P K+  PT P +   +        +P   A        
Sbjct: 502 KSAPTTPKEPSPTTTKEPAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560

Query: 415 PQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-PPRKKRISRQLAST 473
           P    +    TP+E+      T  K   P +  +L  T  + P P  P +   +     T
Sbjct: 561 PTTPKEPAPTTPKETA----PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 616

Query: 474 LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P E A    +A A  TP    P   + PA     +  P      + ++P+
Sbjct: 617 PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 669



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 77/329 (23%), Positives = 119/329 (36%), Gaps = 22/329 (6%)

Query: 258 PARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPC--SPAQPPVLPALAPAPACPLPT 313
           P  P P T +  +PT+    AP  P  P P  P +P   +P +P        AP  P  T
Sbjct: 612 PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 671

Query: 314 SPPV---PAPHVTPHAPGP----PDHPNQPPMMTCERLPCPTA--GLGPLREEAMKPGAA 364
           +P     PAP  TP  P P    P    +P   TC++ P PT   G  P   +   P   
Sbjct: 672 APTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKEPAPTTP 729

Query: 365 SSPLQQVP--APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGP 422
             P    P    P   K+  PT P +    E      + P            P+ T+   
Sbjct: 730 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 789

Query: 423 EDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISRQL-ASTLPAPLE 479
              P  +T +        + P +  E+  P T K+P          + +L A   P  LE
Sbjct: 790 PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 849

Query: 480 NAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLG 539
           N+         +TP    P E  + A    T+         + ++P+     A+ ++   
Sbjct: 850 NSPKEPGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 908

Query: 540 VSVMATDQDSYSTSSTEEELEQFSSPSVK 568
            S + T   +  TS+T ++   F   ++K
Sbjct: 909 ESKI-TATTTQVTSTTTQDTTPFKITTLK 936



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 81/350 (23%), Positives = 122/350 (34%), Gaps = 42/350 (12%)

Query: 249 TDQPPLGNCPARPLPPTS--------DATSPTSRWAPRRPPPPPPVLPLQPC--SPAQPP 298
           T + P    P  P P T+        +    T++ AP  P  P P    +P   +P +P 
Sbjct: 469 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528

Query: 299 VLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
                 PAP  P    PT+P  PAP  T   P P       P    E  P     L P  
Sbjct: 529 PTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 587

Query: 356 EEAMKPGAASSPLQQVP---APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLS 412
            E + P     P    P   AP  P ++  PT P     +   +    +P   A      
Sbjct: 588 PEKLAPTTPEKPAPTTPEELAPTTP-EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 646

Query: 413 LPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQ-LA 471
             P    +    TP+E+      T  K + P ++ E   T  + P P       +++  +
Sbjct: 647 PAPTTPKEPAPTTPKETA----PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 702

Query: 472 STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQ----HPPAQATAHSQSSPEF 527
           +T   P       T     + P P  P+E  +P +  GT       PA  T    +  E 
Sbjct: 703 TTCDKPAPTTPKGTAPTTPKEPAPTTPKE-PAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 761

Query: 528 -----KGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPS 572
                KG  ++ SD        T +++  T+  E       +P+  KKP+
Sbjct: 762 APTTTKGPTSTTSDK---PAPTTPKETAPTTPKE------PAPTTPKKPA 802



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 75/292 (25%), Positives = 110/292 (37%), Gaps = 34/292 (11%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPCSPAQPPVLPA 302
           +A  T + P    P  P P T   T+PT+    AP  P  P P   L P +   P    +
Sbjct: 716 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGPTSTTS 774

Query: 303 LAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAM 359
             PAP  P    PT+P  PAP  TP  P P   P  PP  T E +  PT    P      
Sbjct: 775 DKPAPTTPKETAPTTPKEPAP-TTPKKPAPTT-PETPPPTTSE-VSTPTTTKEPTTIH-K 830

Query: 360 KPGAASSPLQQVPAPPLPAKKNLPTAP----PRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
            P  ++  L   P P   A +N P  P     +   + +  +   +     E D L   P
Sbjct: 831 SPDESTPELSAEPTP--KALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD-LRTTP 887

Query: 416 QGTSDGPEDTPRESTEQGQDTEVKA--------------SDPHSMPELPRTAKQPPVPPP 461
           + T+  P+ T   +T   + TE K               + P  +  L  T   P V   
Sbjct: 888 ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 947

Query: 462 RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHP 513
           +K   + ++   +  P E A+   +A   +  TP P +  ++P     T+ P
Sbjct: 948 KKTITTTEI---MNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 996



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 87/368 (23%), Positives = 126/368 (34%), Gaps = 55/368 (14%)

Query: 244 SSALPTDQPPLGNCPARPLPPTSDATSPTS--RWAP-----------RRPPPPPPVLP-- 288
           ++A  T + P    P  P P T    +PT+    AP           + P P  P  P  
Sbjct: 630 AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 689

Query: 289 --LQPCSPAQPPVLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCER 343
             L P +  +P       PAP  P    PT+P  PAP  TP  P P       P  T  +
Sbjct: 690 KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP-TTPKEPAPTTPKGTAP--TTLK 746

Query: 344 LPCPTAGLGPLREEAMKPGAASSPLQQV---PAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
            P PT    P  +E + P     P       PAP  P K+  PT P      E      +
Sbjct: 747 EPAPTTPKKPAPKE-LAPTTTKGPTSTTSDKPAPTTP-KETAPTTP-----KEPAPTTPK 799

Query: 401 SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPE---------LPR 451
            P           PP  TS+    TP   T   + T +  S   S PE         L  
Sbjct: 800 KPAPTTP----ETPPPTTSE--VSTP---TTTKEPTTIHKSPDESTPELSAEPTPKALEN 850

Query: 452 TAKQPPVPPPRKKRISR-QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGT 510
           + K+P VP  +    ++ ++ +T        +L T     ET T  P    ++  +   T
Sbjct: 851 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP---ETTTAAPKMTKETATTTEKT 907

Query: 511 QHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
                 AT    +S   + +      +L  + +A    +   + T  E+      + K K
Sbjct: 908 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 967

Query: 571 PSMILGKA 578
                 KA
Sbjct: 968 DRATNSKA 975



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 62/287 (21%), Positives = 98/287 (34%), Gaps = 48/287 (16%)

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWAP----RRPPPPPPVLPLQPCSPAQPPVLPALA 304
            T + P    P  P P TS+ ++PT+   P    + P    P L  +P     P  L    
Sbjct: 797  TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP----TPKALENSP 852

Query: 305  PAPACPLPTSPPVPAPHVTPHAPG---------PPDHPNQPPMMTCERLPCPTAGLGPLR 355
              P  P   +P    P +T  A            P+     P MT E     T      +
Sbjct: 853  KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKE-TATTTEKTTESK 911

Query: 356  EEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
              A      S+  Q      +   K    AP      + ++  +                
Sbjct: 912  ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE---------------- 955

Query: 416  QGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP----PRKKRISRQ 469
                + PE+T  P++     + T  K   P   P+ P + K+P   P    P+     R+
Sbjct: 956  --IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRK 1013

Query: 470  LASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQ 516
            + ST+P  L       +AM L+T T    R  Q+P S+    +P ++
Sbjct: 1014 MTSTMP-ELNPTSRIAEAM-LQTTT----RPNQTPNSKLVEVNPKSE 1054



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 27/144 (18%), Positives = 46/144 (31%), Gaps = 7/144 (4%)

Query: 378 AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTE 437
           AK   PT+    + + +     + P +    +     P+  +      P  +T +   T 
Sbjct: 277 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT 336

Query: 438 VKASDPHSMPELPRTAKQP-------PVPPPRKKRISRQLASTLPAPLENAELCTQAMAL 490
            K   P +    P T K+P       P P   K+          P   ++A    +  A 
Sbjct: 337 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 396

Query: 491 ETPTPGPPREGQSPASQAGTQHPP 514
            TP    P   + PA     +  P
Sbjct: 397 TTPKKPAPTTPKEPAPTTPKEPTP 420


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 79/301 (26%), Positives = 105/301 (34%), Gaps = 25/301 (8%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTS-RWAPRRPPPPPPVLPLQ-PCSPAQPPVLPAL 303
           AL T + P    P  P   T    +PT+ + AP  P  P P      P +P +P      
Sbjct: 343 ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 402

Query: 304 APAPACP---LPTSPPVPAPHVTPHAPGPPDHP----NQPPMMTCERLPCPTAGLGPLRE 356
            PAP  P    PT+   PAP  T  AP  P  P     + P  T  + P PT    P   
Sbjct: 403 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 462

Query: 357 EAMKPG-AASSPLQQVPAPPLPA--KKNLPT-----APPRRRVSERVSLEDQSPGMAAEG 408
              +P      P    P  P P   KK  PT     AP   +     + ++ SP    E 
Sbjct: 463 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 522

Query: 409 DQLSLPPQGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPE-LPRTAKQPPVPPPRKKR 465
                 P  T   P  T  P  +T +   T  K   P +  E  P T K+P    P+K  
Sbjct: 523 -----APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 577

Query: 466 ISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSP 525
            +         P E A   T+  A  TP    P   +  A     +  P      + ++P
Sbjct: 578 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 637

Query: 526 E 526
           E
Sbjct: 638 E 638



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 75/293 (25%), Positives = 104/293 (35%), Gaps = 20/293 (6%)

Query: 245 SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALA 304
           SA  T + P    P +P P T    +PT+   P+ P P  P  P        P      A
Sbjct: 427 SAPTTPKEPAPTTPKKPAPTTPKEPAPTT---PKEPTPTTPKEPAPTTKEPAPTTPKEPA 483

Query: 305 P-APACPLPTSPPVPAPHVTPHAPGP-------PDHPNQPPMMTCERLPCPTAGLGP--L 354
           P AP  P PT+P  PAP  TP  P P       P  P +P   T +  P  T    P   
Sbjct: 484 PTAPKKPAPTTPKEPAP-TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 542

Query: 355 REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLP 414
           +     P   S    + PAP  P K+  PT P +   +        +P   A        
Sbjct: 543 KSAPTTPKEPSPTTTKEPAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601

Query: 415 PQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-PPRKKRISRQLAST 473
           P    +    TP+E+      T  K   P +  +L  T  + P P  P +   +     T
Sbjct: 602 PTTPKEPAPTTPKETA----PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 657

Query: 474 LPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P E A    +A A  TP    P   + PA     +  P      + ++P+
Sbjct: 658 PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 710



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 77/329 (23%), Positives = 119/329 (36%), Gaps = 22/329 (6%)

Query: 258 PARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPC--SPAQPPVLPALAPAPACPLPT 313
           P  P P T +  +PT+    AP  P  P P  P +P   +P +P        AP  P  T
Sbjct: 653 PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 712

Query: 314 SPPV---PAPHVTPHAPGP----PDHPNQPPMMTCERLPCPTA--GLGPLREEAMKPGAA 364
           +P     PAP  TP  P P    P    +P   TC++ P PT   G  P   +   P   
Sbjct: 713 APTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKEPAPTTP 770

Query: 365 SSPLQQVP--APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGP 422
             P    P    P   K+  PT P +    E      + P            P+ T+   
Sbjct: 771 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 830

Query: 423 EDTPRESTEQGQDTEVKASDPHSMPEL--PRTAKQPPVPPPRKKRISRQL-ASTLPAPLE 479
              P  +T +        + P +  E+  P T K+P          + +L A   P  LE
Sbjct: 831 PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 890

Query: 480 NAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLG 539
           N+         +TP    P E  + A    T+         + ++P+     A+ ++   
Sbjct: 891 NSPKEPGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTT 949

Query: 540 VSVMATDQDSYSTSSTEEELEQFSSPSVK 568
            S + T   +  TS+T ++   F   ++K
Sbjct: 950 ESKI-TATTTQVTSTTTQDTTPFKITTLK 977



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 81/350 (23%), Positives = 122/350 (34%), Gaps = 42/350 (12%)

Query: 249 TDQPPLGNCPARPLPPTS--------DATSPTSRWAPRRPPPPPPVLPLQPC--SPAQPP 298
           T + P    P  P P T+        +    T++ AP  P  P P    +P   +P +P 
Sbjct: 510 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569

Query: 299 VLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
                 PAP  P    PT+P  PAP  T   P P       P    E  P     L P  
Sbjct: 570 PTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 628

Query: 356 EEAMKPGAASSPLQQVP---APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLS 412
            E + P     P    P   AP  P ++  PT P     +   +    +P   A      
Sbjct: 629 PEKLAPTTPEKPAPTTPEELAPTTP-EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 687

Query: 413 LPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQ-LA 471
             P    +    TP+E+      T  K + P ++ E   T  + P P       +++  +
Sbjct: 688 PAPTTPKEPAPTTPKETA----PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 743

Query: 472 STLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQ----HPPAQATAHSQSSPEF 527
           +T   P       T     + P P  P+E  +P +  GT       PA  T    +  E 
Sbjct: 744 TTCDKPAPTTPKGTAPTTPKEPAPTTPKE-PAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 802

Query: 528 -----KGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPS 572
                KG  ++ SD        T +++  T+  E       +P+  KKP+
Sbjct: 803 APTTTKGPTSTTSDK---PAPTTPKETAPTTPKE------PAPTTPKKPA 843



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 75/292 (25%), Positives = 110/292 (37%), Gaps = 34/292 (11%)

Query: 245  SALPTDQPPLGNCPARPLPPTSDATSPTS--RWAPRRPPPPPPVLPLQPCSPAQPPVLPA 302
            +A  T + P    P  P P T   T+PT+    AP  P  P P   L P +   P    +
Sbjct: 757  TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGPTSTTS 815

Query: 303  LAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAM 359
              PAP  P    PT+P  PAP  TP  P P   P  PP  T E +  PT    P      
Sbjct: 816  DKPAPTTPKETAPTTPKEPAP-TTPKKPAPTT-PETPPPTTSE-VSTPTTTKEPTTIH-K 871

Query: 360  KPGAASSPLQQVPAPPLPAKKNLPTAP----PRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
             P  ++  L   P P   A +N P  P     +   + +  +   +     E D L   P
Sbjct: 872  SPDESTPELSAEPTP--KALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD-LRTTP 928

Query: 416  QGTSDGPEDTPRESTEQGQDTEVKA--------------SDPHSMPELPRTAKQPPVPPP 461
            + T+  P+ T   +T   + TE K               + P  +  L  T   P V   
Sbjct: 929  ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 988

Query: 462  RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHP 513
            +K   + ++   +  P E A+   +A   +  TP P +  ++P     T+ P
Sbjct: 989  KKTITTTEI---MNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 1037



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 87/368 (23%), Positives = 126/368 (34%), Gaps = 55/368 (14%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTS--RWAP-----------RRPPPPPPVLP-- 288
            ++A  T + P    P  P P T    +PT+    AP           + P P  P  P  
Sbjct: 671  AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 730

Query: 289  --LQPCSPAQPPVLPALAPAPACP---LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCER 343
              L P +  +P       PAP  P    PT+P  PAP  TP  P P       P  T  +
Sbjct: 731  KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP-TTPKEPAPTTPKGTAP--TTLK 787

Query: 344  LPCPTAGLGPLREEAMKPGAASSPLQQV---PAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
             P PT    P  +E + P     P       PAP  P K+  PT P      E      +
Sbjct: 788  EPAPTTPKKPAPKE-LAPTTTKGPTSTTSDKPAPTTP-KETAPTTP-----KEPAPTTPK 840

Query: 401  SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPE---------LPR 451
             P           PP  TS+    TP   T   + T +  S   S PE         L  
Sbjct: 841  KPAPTTP----ETPPPTTSE--VSTP---TTTKEPTTIHKSPDESTPELSAEPTPKALEN 891

Query: 452  TAKQPPVPPPRKKRISR-QLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGT 510
            + K+P VP  +    ++ ++ +T        +L T     ET T  P    ++  +   T
Sbjct: 892  SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP---ETTTAAPKMTKETATTTEKT 948

Query: 511  QHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKK 570
                  AT    +S   + +      +L  + +A    +   + T  E+      + K K
Sbjct: 949  TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 1008

Query: 571  PSMILGKA 578
                  KA
Sbjct: 1009 DRATNSKA 1016



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 62/287 (21%), Positives = 98/287 (34%), Gaps = 48/287 (16%)

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWAP----RRPPPPPPVLPLQPCSPAQPPVLPALA 304
            T + P    P  P P TS+ ++PT+   P    + P    P L  +P     P  L    
Sbjct: 838  TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP----TPKALENSP 893

Query: 305  PAPACPLPTSPPVPAPHVTPHAPG---------PPDHPNQPPMMTCERLPCPTAGLGPLR 355
              P  P   +P    P +T  A            P+     P MT E     T      +
Sbjct: 894  KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKE-TATTTEKTTESK 952

Query: 356  EEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
              A      S+  Q      +   K    AP      + ++  +                
Sbjct: 953  ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE---------------- 996

Query: 416  QGTSDGPEDT--PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP----PRKKRISRQ 469
                + PE+T  P++     + T  K   P   P+ P + K+P   P    P+     R+
Sbjct: 997  --IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRK 1054

Query: 470  LASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQ 516
            + ST+P  L       +AM L+T T    R  Q+P S+    +P ++
Sbjct: 1055 MTSTMP-ELNPTSRIAEAM-LQTTT----RPNQTPNSKLVEVNPKSE 1095



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 27/144 (18%), Positives = 46/144 (31%), Gaps = 7/144 (4%)

Query: 378 AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTE 437
           AK   PT+    + + +     + P +    +     P+  +      P  +T +   T 
Sbjct: 318 AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTT 377

Query: 438 VKASDPHSMPELPRTAKQP-------PVPPPRKKRISRQLASTLPAPLENAELCTQAMAL 490
            K   P +    P T K+P       P P   K+          P   ++A    +  A 
Sbjct: 378 PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 437

Query: 491 ETPTPGPPREGQSPASQAGTQHPP 514
            TP    P   + PA     +  P
Sbjct: 438 TTPKKPAPTTPKEPAPTTPKEPTP 461


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 106/442 (23%), Positives = 153/442 (34%), Gaps = 93/442 (21%)

Query: 186  PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIE-DCS 244
            PP     P  PP    P  PL S   P+A  A                   P+F++    
Sbjct: 629  PPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA------------------APMFVKYSTI 670

Query: 245  SALPTDQPPLGNCPARPLPPTSDATS-------PTSRWAPRRPPPPPPVLPLQPCSPAQP 297
            + L       G     P PP   + S       P +   P  PPPPPP  P    +  +P
Sbjct: 671  TRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKP 730

Query: 298  -PVLPALAPAPACPLP-----------TSPPVPAPHVTPHAPGPPDHPNQP--------- 336
             P  P+L    A P P            +PP P P     AP PP  P +P         
Sbjct: 731  APCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTS 790

Query: 337  -----PMMTCERLPCPTAGLGPLREEAMKPGA---ASSPLQQVPAPP--LPAKKNLPTAP 386
                 P++T    P PT  + P +++   P +    S P   VP PP  LP +++    P
Sbjct: 791  TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKP 850

Query: 387  PRRRVS------ERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPR-ESTEQGQDTEVK 439
            P   +S      ++++ +   P      +   L P   +  P+  P  ++  + Q + + 
Sbjct: 851  PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIP 910

Query: 440  ASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTP---G 496
               P   P  P ++   P PPP          S +PAP              +PTP   G
Sbjct: 911  VPSPDFPPPPPESSLVFPPPPP----------SPVPAP------PPPPPPTASPTPDKSG 954

Query: 497  PPREGQSPASQAGTQHPP----AQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYST 552
             P +  S  S  G + PP      ++  S S  E         DSL VS      +S S 
Sbjct: 955  SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL-VSKFTPPAESGSP 1013

Query: 553  SSTEEELEQFSSPSVKKKPSMI 574
            S      E    P+   KP  +
Sbjct: 1014 SK-----ETLPPPAAPPKPGKL 1030



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 78/298 (26%), Positives = 109/298 (36%), Gaps = 41/298 (13%)

Query: 252 PPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPL 311
           PPL   P    P T+   SP     P  PPPPPP  P  P  P  PP+    AP+     
Sbjct: 607 PPLSPQPKIVTPYTASQPSP-----PLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAA 661

Query: 312 PT----SPPVPAPHVTPHAPGPPDHPNQPPMMTCE----RLPCPTAGLGPLREEAMKPGA 363
           P     S      + + H+ G    P  PP+M  +    ++  P  G+ P       P  
Sbjct: 662 PMFVKYSTITRLQNASQHS-GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720

Query: 364 ASSPLQQV-PAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQL--SLPPQGTSD 420
             S + Q+ PAP  P+       PP  ++ +   +   +P        +   LPPQ    
Sbjct: 721 PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780

Query: 421 GPEDTPR-ESTEQGQDTEVKASDPHSMPELPRTAKQP----------------PVPPPRK 463
                P   ST+       +A+ P   P +P   KQP                PVPPP  
Sbjct: 781 PLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL 840

Query: 464 KRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQS------PASQAGTQHPPA 515
            +     A   P+PL       + +A + P P  P   +S      PA+ A  Q PPA
Sbjct: 841 PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVA-PQSPPA 897



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 75/252 (29%), Positives = 93/252 (36%), Gaps = 53/252 (21%)

Query: 291 PCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQ--------PPMM--- 339
           P SP    V P  A  P+ PLP  PP P P   P  P PP  P+Q         PM    
Sbjct: 608 PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667

Query: 340 -TCERLPCPTAGLGPL---------REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRR 389
            T  RL   +   G L         + +++KP     P   VP PP       P  PP  
Sbjct: 668 STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPP-------PPPPPPT 720

Query: 390 RVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL 449
             S    L+      A    Q S PP          P +  +    T+V    P   P +
Sbjct: 721 PGSAMAQLKPAP--CAPSLPQFSAPP---------PPLKIHQVQHITQVAPPTPPPPPPI 769

Query: 450 PRTAKQPPVPPPRKKRISRQLASTLPAPLEN---AELCTQAMALETPTPGPPREGQSPAS 506
           P  A  PP  PP+          T+PAP      A + TQA A  TPTP  P   + PA 
Sbjct: 770 P--APLPPQAPPKP-------LVTIPAPTSTKTVAPVVTQA-APPTPTPPVPPAKKQPAF 819

Query: 507 QAGTQHPPAQAT 518
            A +  PP+  T
Sbjct: 820 PA-SYIPPSPPT 830



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 67/326 (20%), Positives = 102/326 (31%), Gaps = 45/326 (13%)

Query: 247  LPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSP------------ 294
            LP  Q      P  PL P        +   P  PPP PP +  QP  P            
Sbjct: 840  LPKQQSFCAKPPPSPLSPVPSVVKQIASQFP--PPPTPPAMESQPLKPVPANVAPQSPPA 897

Query: 295  --AQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLG 352
              A+P   P+  P P+   P  PP  +    P  P P   P  PP  T    P  +   G
Sbjct: 898  VKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPG 957

Query: 353  PLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLS 412
                +   PG    P        + +        P+R   + +  +   P  +    + +
Sbjct: 958  KKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKET 1017

Query: 413  LPPQGTSDGPEDTPRESTE-------------------QGQDTEVKASDPHSMPELPRTA 453
            LPP      P                            +G+D+ V+   P S  + P   
Sbjct: 1018 LPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPP 1077

Query: 454  KQPPVPPPR-------KKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPAS 506
             +  +P P            S ++A   P P + +++   ++    P   P R   +  +
Sbjct: 1078 PETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKM---SVKKAPPPTRPKRNDSTRLT 1134

Query: 507  QAGTQHPPAQATAHSQSSPEFKGSLA 532
            QA     P  AT   Q     K SL+
Sbjct: 1135 QAEISEQPTMATVVPQVPTSPKSSLS 1160


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 95/351 (27%), Positives = 127/351 (36%), Gaps = 60/351 (17%)

Query: 187  PQERGKP---AEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDC 243
            PQER +    AE P    P   +VS+  P A D   A  +    G      + P   +  
Sbjct: 701  PQERSQQPLSAEGPHLSVPASVIVSA-PPPAQDPAPATPVAKGAG------LGPQAPDSQ 753

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRW---APRRPPP----PPPVLPLQPCSPAQ 296
            +S  P  Q P    P +   P+S  + P       +P  P P    PP   P +P S ++
Sbjct: 754  ASPAPAPQIPAA-APLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSR 812

Query: 297  PPVLPALAPAPACPLPTSPP-VPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
            PP  P L P   CP P +PP +P   V  +  G P     PP       P PTA  GP  
Sbjct: 813  PPSEPPLHP---CPPPQAPPTLPGIFVIQNQLGVP-----PPASN----PAPTAP-GP-- 857

Query: 356  EEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPP 415
                 P     P  Q P  PLP   +LP +     V+       + P       QL  PP
Sbjct: 858  -----PQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPP 912

Query: 416  QGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLP 475
               S GP  +P              + P ++  +P  A  PP PPPR  ++       LP
Sbjct: 913  ---SQGPHKSP--------------TPPPTLHLVPEPAAPPP-PPPRTFQMVTTPFPALP 954

Query: 476  AP---LENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQS 523
             P   LE        + L+    G P   Q+  S      P A      Q+
Sbjct: 955  QPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQA 1005



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 105/420 (25%), Positives = 143/420 (34%), Gaps = 132/420 (31%)

Query: 244  SSALPTDQPPLGNCPARPLP-PTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQ-PPVLP 301
            S +LP  Q PLG+ P  P P PT   + P SR  P+    PP   PL PC P Q PP LP
Sbjct: 776  SPSLP-HQAPLGDSPHLPSPHPTRPPSRPPSR--PQSVSRPPSEPPLHPCPPPQAPPTLP 832

Query: 302  ALA--------------PAPACPLPTSPPV------------PAPHVTPHAP-------- 327
             +               PAP  P P  PP+            PAPH+ P +         
Sbjct: 833  GIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSS 892

Query: 328  ----------------------GPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAAS 365
                                  GP   P  PP  T   +P P A           P   +
Sbjct: 893  ETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPP--TLHLVPEPAA--------PPPPPPRT 942

Query: 366  SPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDT 425
              +   P P LP  K L       +V   + L++++ G  A       P   TS GP  +
Sbjct: 943  FQMVTTPFPALPQPKAL--LERFHQVPSGIILQNKAGGAPA------APQTSTSLGPLTS 994

Query: 426  PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCT 485
            P  S        V    P   P  P  A   P P P        +A+T   PL  AE   
Sbjct: 995  PAAS------VLVSGQAPSGTPTAPSHA---PAPAP--------MAATGLPPLLPAE--N 1035

Query: 486  QAMALETPT----------PGPPREGQSPASQAGTQHPPAQATAH-------------SQ 522
            +A A   PT          PG P   Q  +  +G + PP    +              S 
Sbjct: 1036 KAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSV 1095

Query: 523  SSPEFKGSLASLSDSLG--------VSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMI 574
              P++K +  S  D+L            + +  D +     +EE E  S+  +K+  +M+
Sbjct: 1096 LHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYH---KVDEEFETVSTQLLKRTQAML 1152



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 97/377 (25%), Positives = 137/377 (36%), Gaps = 69/377 (18%)

Query: 214 AHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPT--SDATSP 271
           AH A+      + VG   L F  P+ +   + +LPT   P    PA P   T     T P
Sbjct: 536 AHSAHILSAAPIQVGQPAL-FQMPVSL--AAGSLPTQSQP---APAGPAATTVLQGVTLP 589

Query: 272 TSRWAPRRPPPPPPVLPLQPCSPAQP-----PVLPALAPAPACPLPTSPPVPAPHVTPHA 326
            S  A    P       +QP +PA       PVL  + PAP  P   S P+P     P A
Sbjct: 590 PSAVAMLNTPDGL----VQPATPAAATGEAAPVL-TVQPAPQAPPAVSTPLPLGLQQPQA 644

Query: 327 PGPPDHPN----QPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNL 382
             PP  P      PP  T    P P+            PG ASSP + V   P       
Sbjct: 645 QQPPQAPTPQAAAPPQAT---TPQPS------------PGLASSPEKIVLGQP------- 682

Query: 383 PTAPPRRRVSER-----VSLEDQSPGMAAEGDQLSLPPQ--GTSDGPEDTPRESTEQGQD 435
           P+A P   +++      +  E     ++AEG  LS+P     ++  P   P  +T   + 
Sbjct: 683 PSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKG 742

Query: 436 TEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALET--- 492
             +    P S    P  A Q P   P K           P P  +  L  QA   ++   
Sbjct: 743 AGLGPQAPDSQAS-PAPAPQIPAAAPLKG----------PGPSSSPSLPHQAPLGDSPHL 791

Query: 493 PTPGPPREGQSPASQ-AGTQHPPAQATAHSQSSPEFKGSLAS---LSDSLGVSVMATDQD 548
           P+P P R    P S+      PP++   H    P+   +L     + + LGV   A++  
Sbjct: 792 PSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPA 851

Query: 549 SYSTSSTEEELEQFSSP 565
             +    +  L   S P
Sbjct: 852 PTAPGPPQPPLRPQSQP 868



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 58/217 (26%), Positives = 72/217 (33%), Gaps = 25/217 (11%)

Query: 263  PPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAP---APACP-LPTSPPV- 317
            PP   AT   +   PR PPPPPP   +       PP  P   P   AP CP LP      
Sbjct: 1333 PPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLRKTYR 1392

Query: 318  ------PAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK-------PGAA 364
                   AP  TP        P   P    E        L  + +E  +       P  A
Sbjct: 1393 ENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPA 1452

Query: 365  SSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQS-PGMAAEGDQLSLPPQGTSD--- 420
            +S  Q    P   A   LP  P +RR SE   ++  S    + + D L+   Q   D   
Sbjct: 1453 ASAAQGTGDPDWEA-PGLP--PAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSIL 1509

Query: 421  GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPP 457
              +  P  +          A  P S P L R    PP
Sbjct: 1510 NLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPP 1546



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 74/248 (29%), Positives = 91/248 (36%), Gaps = 56/248 (22%)

Query: 279  RPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPM 338
            +PPPPP  L +     A+PP  P          P  PP    + T   P PP  P + P+
Sbjct: 1332 QPPPPPATLKV-----AEPPPRPP---------PPPPPTGQMNGTVDHP-PPAAPERKPL 1376

Query: 339  MT---CERLPCPTAGLGPLREEAMKPGA-----ASSPLQQVPAPPLPAKKNLPTAPPRRR 390
             T   C RLP         RE    PGA     A       PA PLPAK +  T+   R 
Sbjct: 1377 GTAPHCPRLPLRKT----YRENVGGPGAPEGTPAGRARGGSPA-PLPAKVDEATSGLIRE 1431

Query: 391  VSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQ-DTEVKASDPHSMPEL 449
                         +AA  D+L    Q    GP   P  S  QG  D + +A  P   P  
Sbjct: 1432 -------------LAAVEDELY---QRMLKGPPPEPAASAAQGTGDPDWEA--PGLPPAK 1473

Query: 450  PRTAKQPPVPPPRKKRISRQLASTLPAPLENA---ELCTQAMALETPTPGPPREGQSPAS 506
             R ++ P V        S Q   TL   L++A    L  Q     TP P  P      A+
Sbjct: 1474 RRKSESPDVDQASFSSDSPQ-DDTLTEHLQSAIDSILNLQQAPGRTPAPSYPH-----AA 1527

Query: 507  QAGTQHPP 514
             AGT   P
Sbjct: 1528 SAGTPASP 1535



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 40/137 (29%), Positives = 51/137 (37%), Gaps = 15/137 (10%)

Query: 293 SPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQP---PMMTCERLPCPTA 349
           +P   P    LA AP   L +SP VPAP+V  H    P  P      P    +  P P A
Sbjct: 315 APTGTPSGQPLAVAPG--LGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFA 372

Query: 350 GLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGD 409
             G       +PGA    L Q P  P    +NL T     +  + V L    P  A + +
Sbjct: 373 PAGATLTIQGEPGA----LPQQPKAP----QNL-TFMAAGKAGQNVVLSG-FPAPALQAN 422

Query: 410 QLSLPPQGTSDGPEDTP 426
               PP  T+      P
Sbjct: 423 VFKQPPATTTGAAPPQP 439


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 97/368 (26%), Positives = 132/368 (35%), Gaps = 64/368 (17%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPP-----PPPVLPLQPCSPA-QPPV 299
           ALP   PP    P  P PP    + PTS   P  PP      PPPVLP    S A  PPV
Sbjct: 550 ALPATVPP----PGMP-PPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPV 604

Query: 300 LP-----ALAPAPACPL-PTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGP 353
           LP     + AP P  PL P S   P P + P  PG P     PP +T   +P  ++    
Sbjct: 605 LPPPSLSSTAPPPVMPLPPLSSATPPPGIPP--PGVPQ--GIPPQLTAAPVPPASSSQSS 660

Query: 354 LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLE---------DQSPGM 404
              E  +P    +P+    APP      L +A P  +V+ +  L              G+
Sbjct: 661 QVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALPYSSFSSDQGL 720

Query: 405 AAEGDQLSLPPQGTSDGP-------EDTPRESTEQGQ-----DTEVKASDPHSMPELPR- 451
                  S P     D P        D PR S  +       D   +  D  S  E PR 
Sbjct: 721 GESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYLESPRGPRFDGPRRFEDLGSRCEGPRP 780

Query: 452 -----TAKQPPVPPPRKK----RISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQ 502
                   +P  P PR +      ++     +P    +    T + +L     GP  +G 
Sbjct: 781 KGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPRGPASQFYITPSTSLSPRQSGPQWKGP 840

Query: 503 SPA-SQAGTQHPPAQ-----------ATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSY 550
            PA  Q   Q P +Q           A   S     FK   A+ S +  V  +   Q + 
Sbjct: 841 KPAFGQQHQQQPKSQAEPLSGNKEPLADTSSNQQKNFKMQSAAFSIAADVKDVKAAQSNE 900

Query: 551 STSSTEEE 558
           + S +++E
Sbjct: 901 NLSDSQQE 908



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 77/271 (28%), Positives = 96/271 (35%), Gaps = 40/271 (14%)

Query: 271 PTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
           P S+  P  P  PPPVLP     P  PP LPA  P P  P P  PP     V P      
Sbjct: 522 PYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPP------ 575

Query: 331 DHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRR 390
             P  PP ++       +AG  P+    + P + SS     P P LP      TAPP   
Sbjct: 576 --PGMPPSLS-------SAGPPPV----LPPPSLSS---AGPPPVLPPPSLSSTAPPPVM 619

Query: 391 VSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELP 450
               +S     PG+   G    +PPQ T+      P  S+ Q      K   P  +P   
Sbjct: 620 PLPPLSSATPPPGIPPPGVPQGIPPQLTA---APVPPASSSQSSQVPEKPR-PALLPTPV 675

Query: 451 RTAKQPPV---PPPRKKRISRQLASTLPAPLENAEL------CTQAMALETPTPGPPREG 501
                PP    PP +    S Q+ S   APL  + L        Q +   +  P  P   
Sbjct: 676 SFGSAPPTTYHPPLQSAGPSEQVNS--KAPLSKSALPYSSFSSDQGLGESSAAPSQPITA 733

Query: 502 --QSPASQAG-TQHPPAQATAHSQSSPEFKG 529
               P    G    PP  +   S   P F G
Sbjct: 734 VKDMPVRSGGLLPDPPRSSYLESPRGPRFDG 764



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 79/277 (28%), Positives = 107/277 (38%), Gaps = 35/277 (12%)

Query: 247 LPTDQPPL--GNCPARPLPPTSDATSPTSRWAPRRPPPP-PPVLPLQPCSPAQPPVLPAL 303
           LPT  PP+   + P   +PP   AT P     P  PPP  PP LP     P  PP L + 
Sbjct: 530 LPTMPPPVLPPSLPPPVMPPALPATVPP----PGMPPPVMPPSLPTSVPPPGMPPSLSSA 585

Query: 304 APAPACPLPT-----SPPV-PAPHVTPHAPGPPDHPNQPPMMTC---ERLPCP--TAGLG 352
            P P  P P+      PPV P P ++  AP PP  P  PP+ +      +P P    G+ 
Sbjct: 586 GPPPVLPPPSLSSAGPPPVLPPPSLSSTAP-PPVMP-LPPLSSATPPPGIPPPGVPQGIP 643

Query: 353 PLREEAMKPGAASSPLQQVPAPPLPAKKNLP----TAPPRRRVSERVSLEDQSPGMAAEG 408
           P    A  P A+SS   QVP  P PA    P    +APP    +    L+   P      
Sbjct: 644 PQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPP---TTYHPPLQSAGPSEQVN- 699

Query: 409 DQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISR 468
              S  P   S  P  +       G+ +   +    ++ ++P  +      PPR   +  
Sbjct: 700 ---SKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYLES 756

Query: 469 QLASTLPAPLENAELCTQAMALETPTP-GPPREGQSP 504
                   P    +L ++    E P P GP  EG  P
Sbjct: 757 PRGPRFDGPRRFEDLGSRC---EGPRPKGPRFEGNRP 790



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 65/265 (24%), Positives = 96/265 (36%), Gaps = 31/265 (11%)

Query: 263 PPTSDATSPTSRWAPRR---PPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPA 319
           PP S    P S   P +   PPP PP     P S    P LP     PA P P+  P   
Sbjct: 146 PPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTS--SQPYLP-----PAQPSPSQSPPSQ 198

Query: 320 PHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAK 379
            ++ P         +    ++  +   P++   P R     P    S  Q +  PP    
Sbjct: 199 SYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSR-----PSQGHSKSQLLAPPP---- 249

Query: 380 KNLPTAPPRRRVS-ERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEV 438
              P+APP  + + ++  LE  +   + E  Q +  P    D    TP+E  +      +
Sbjct: 250 ---PSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEP----DPSTMTPQEQQQYWYRQHL 302

Query: 439 KASDPHSMPELPRTAKQPPV----PPPRKKRISRQLASTLPAPLENAELCTQAMALETPT 494
            +    +   LP   K P V    P P K+ ++    S +P    + E        E P 
Sbjct: 303 LSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPPLPPPNEEVPP 362

Query: 495 PGPPREGQSPASQAGTQHPPAQATA 519
           P PP E QS   +   +    QA A
Sbjct: 363 PLPPEEPQSEDPEEDARLKQLQAAA 387



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 41/138 (29%), Positives = 51/138 (36%), Gaps = 16/138 (11%)

Query: 262  LPPTSDATSPTSRWAPRRPPP----PPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPV 317
            LPP       TS      PPP    PPP +   P S  +P   PA +  P     T PPV
Sbjct: 1489 LPPQESRLQNTSSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSVPV----TRPPV 1544

Query: 318  PAPHVTPHAPGPPDHPNQPPMMTC---ERLPCPT-AGLGPLREEAMKPGAASSPLQQVPA 373
            P P   P  P PP  P   P  +    ER    +  GL    +E        S    +P+
Sbjct: 1545 PIPPPPPPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPS 1604

Query: 374  ----PPLPAKKNLPTAPP 387
                PP P   ++P   P
Sbjct: 1605 APVLPPPPVHSSIPPPGP 1622



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 78/351 (22%), Positives = 111/351 (31%), Gaps = 83/351 (23%)

Query: 282 PPPPVLPLQPCSPAQPPV-LPALAPAPACPLPTSPPVPA--------------------- 319
           PPPPV       P  PPV LP  +P P     T+P  P+                     
Sbjct: 15  PPPPV-------PPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQM 67

Query: 320 ----------PHVTPHAPGPPD-----------HPNQPPMMTCERLPCPTAGLGPLREEA 358
                     PH  P  P PP             P  PPM      P P   L   +++ 
Sbjct: 68  HQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMP-----PPPGPALSYQKQQQ 122

Query: 359 MK-----------PGAASSPLQQVP-APPLPAKKNLPTA-----PPRRRVSERVSLEDQS 401
            K           PG     L+  P +PP+P    +P +     PP+   S       Q 
Sbjct: 123 YKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQP 182

Query: 402 PGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPP 461
               A+      PP  +   P  TP  S+         +   HS   LP +   P  P  
Sbjct: 183 YLPPAQPSPSQSPPSQSYLAP--TPSYSSSSSSSQSYLS---HSQSYLPSSQASPSRPSQ 237

Query: 462 RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHS 521
              + S+ LA   P+     +   Q   LE+       E Q    QA  +  P+  T   
Sbjct: 238 GHSK-SQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQ----QAAPEPDPSTMTPQE 292

Query: 522 QSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEEL-EQFSSPSVKKKP 571
           Q    ++  L SL     V +    +       T E + E+ + P+  + P
Sbjct: 293 QQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVP 343



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 33/117 (28%), Positives = 44/117 (37%), Gaps = 32/117 (27%)

Query: 252  PPLGNCPA---RPLPPTSDATSPTSRW-APRRPPPPPPVLPLQPCSPAQPPVLPALA--- 304
            PP+G  P    RP  P + ++ P +R   P  PPPPPP  PL P  P   P   A+    
Sbjct: 1516 PPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPP--PLPPPPPVIKPQTSAVEQER 1573

Query: 305  ----------------------PAPACPLPTSPPVPAPHVTPHAPGPPDHP-NQPPM 338
                                   +    +P++P +P P V    P P   P   PPM
Sbjct: 1574 WDEDSFYGLWDTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSIPPPGPVPMGMPPM 1630



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 27/80 (33%), Positives = 32/80 (40%), Gaps = 11/80 (13%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPAL 303
            +S+ P   PP G+   RP PP      P S   P  PP    V   +P  P  PP  P  
Sbjct: 1499 TSSRPGMYPPPGSY--RPPPPMGKP--PGSIVRPSAPPARSSVPVTRPPVPIPPPPPPP- 1553

Query: 304  APAPACPLPTSPPVPAPHVT 323
                  PLP  PPV  P  +
Sbjct: 1554 ------PLPPPPPVIKPQTS 1567


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 76/287 (26%), Positives = 101/287 (35%), Gaps = 32/287 (11%)

Query: 241 EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL 300
           ED  +  P     L N     +P  S  +S   +   R     PP  P    SP   P +
Sbjct: 508 EDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPI 567

Query: 301 PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK 360
               P P  P P   P       P AP PP  P          +P P      LRE   +
Sbjct: 568 TTSPPVPQEPAPVPSP-------PRAPTPPSTP----------VPLPEKRRSILREPTFR 610

Query: 361 PGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSL------- 413
             + +  L   P PP P     P+ PP    S R  L  ++P        L +       
Sbjct: 611 WTSLTRELP--PPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTP 668

Query: 414 PPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLAST 473
           PP G  + PE  P  + +   + E +A    +   LPR A  P V  P K  +S   A  
Sbjct: 669 PPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFA--PVVTTPVKAEVSPHGAPA 726

Query: 474 LP-APLENAELCTQAMALET---PTPGPPREGQSPASQAGTQHPPAQ 516
           L   P   A+L     AL+T   P   PP + Q     +  Q PP +
Sbjct: 727 LSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLE 773



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 76/289 (26%), Positives = 109/289 (37%), Gaps = 46/289 (15%)

Query: 271 PTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPP 330
           P +     + PPP    PL P +P+ PP LP   P+ + P P  PP P P   P  P PP
Sbjct: 392 PAAEKEEAKLPPP----PLTPPAPSPPPPLP--PPSTSPPPPLCPPPPPPVSPPPLPSPP 445

Query: 331 DHPNQ-------PPMM--TCERLPCPTAGLGPL--REEAMKPGAASSPLQQVPAPPLPA- 378
             P Q       PP++  TC R      G  PL   + A +  A + P    P  P P+ 
Sbjct: 446 PPPAQEEQEESPPPVVPATCSR----KRGRPPLTPSQRAEREAARAGPEGTSPPTPTPST 501

Query: 379 -----KKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQ-LSLPPQGTSDGPEDTPRESTEQ 432
                 ++ PT  P+     +   +   P ++A   + +  P +   + P   P+     
Sbjct: 502 ATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSP 561

Query: 433 GQDTEVKAS-----DPHSMPELPRTAKQP--PVPPPRKKRISRQLASTLPAPLENAELCT 485
                +  S     +P  +P  PR    P  PVP P K+R      S L  P       T
Sbjct: 562 VLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRR------SILREPTFRWTSLT 615

Query: 486 QAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASL 534
           + +    P P PP     P + A +   P    A     P+F  S A L
Sbjct: 616 RELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRA-----PQFTPSEAHL 659



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 75/298 (25%), Positives = 103/298 (34%), Gaps = 65/298 (21%)

Query: 193  PAEPPRDRA--PGFP--LVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALP 248
            PA+P R  A  PG P   V SL P       A    + V       +  +F++      P
Sbjct: 2156 PADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNK-----LGQVFVKMAGEGEP 2210

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWA-----------------PRRPPPPPPVLPLQP 291
               PP    P  PLPPT   T+PTS W                  P  PPPPPP+  +  
Sbjct: 2211 V--PPPVKQP--PLPPTISPTAPTS-WTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLS 2265

Query: 292  CSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGL 351
              PA PP         +     SPP P P+  P      +     P +       P  G 
Sbjct: 2266 SGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQV-------PGLGS 2318

Query: 352  GPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQL 411
            G      MK       L  +  P  PA +  P             L+++SP +    D  
Sbjct: 2319 GGFSRVRMKTPTVRGVL-DLDRPGEPAGEESPG-----------PLQERSPLLPLPEDG- 2365

Query: 412  SLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQ 469
              PPQ   DGP D   ES       E  +S+           ++PP P  ++ +  ++
Sbjct: 2366 --PPQ-VPDGPPDLLLESQWHHYSGEASSSE-----------EEPPSPDDKENQAPKR 2409



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 59/235 (25%), Positives = 82/235 (34%), Gaps = 46/235 (19%)

Query: 286 VLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLP 345
           ++P      A+ P  P   PAP+ P    PP+P P     +P PP  P  PP ++   LP
Sbjct: 390 MMPAAEKEEAKLPPPPLTPPAPSPP----PPLPPPST---SPPPPLCPPPPPPVSPPPLP 442

Query: 346 CPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMA 405
            P             P  A    ++ P P +PA  +     P    S+R   E    G  
Sbjct: 443 SP------------PPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPE 490

Query: 406 AEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMP----------ELPRTAKQ 455
                   P   T   PED+P  + +    T +K      MP          + PR    
Sbjct: 491 GTSPPTPTPSTATGGPPEDSPTVAPK--STTFLKNIRQFIMPVVSARSSRVIKTPRRFMD 548

Query: 456 PPVPPPRKKRISRQL----ASTLPAPLENAELCTQAMALETPTPGPPREGQSPAS 506
              P P K  +S  L     ++ P P E A           P P PPR    P++
Sbjct: 549 EDPPKPPKVEVSPVLRPPITTSPPVPQEPA-----------PVPSPPRAPTPPST 592



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 62/259 (23%), Positives = 100/259 (38%), Gaps = 32/259 (12%)

Query: 234 FVNPIFIEDCSSALPTDQPPLGNCPARP----LPPTSDATSPTSRWAPRRPPPPPPVLPL 289
           F+ P+     S  + T +  +   P +P    + P       TS   P+ P P P   P 
Sbjct: 527 FIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSP-PR 585

Query: 290 QPCSPAQPPVLP----ALAPAPAC-------PLPTSPPVPAPHVTPHAPGPPDHPNQPPM 338
            P  P+ P  LP    ++   P          LP  PP P P   P  P  P   ++ P+
Sbjct: 586 APTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPL 645

Query: 339 MTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRV--SERVS 396
           +       P+     + E  + P    +P  + P P  P   + P  P  R V  +  +S
Sbjct: 646 LLRAPQFTPSEAHLKIYESVLTPPPLGAP--EAPEPEPPPADDSPAEPEPRAVGRTNHLS 703

Query: 397 LEDQSPGMAAEGDQLSLPPQGT---SDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTA 453
           L   +P +     +  + P G    S+GP+ T  +  +  Q  + +   P ++P  P+  
Sbjct: 704 LPRFAP-VVTTPVKAEVSPHGAPALSNGPQ-TQAQLLQPLQALQTQLL-PQALPP-PQPQ 759

Query: 454 KQPP-----VPPPRKKRIS 467
            QPP     +PP  K RI+
Sbjct: 760 LQPPPSPQQMPPLEKARIA 778



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 48/186 (25%), Positives = 66/186 (35%), Gaps = 35/186 (18%)

Query: 325  HAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAAS--SPLQQVPAPPLPAKKNL 382
            H+P P   P             P     PL  + + PGA    SP+Q +  P  P   + 
Sbjct: 1806 HSPAPSSEP-------------PGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSA 1852

Query: 383  PTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASD 442
            P   PR     R+ + + SP           P  G S GP  +P   +           D
Sbjct: 1853 PPPAPRSFSGARIKVPNYSPSRR--------PLGGVSFGPLPSPGSPSSLTHHIPT-VGD 1903

Query: 443  PHSMPELPRTAKQP----PVPPPRK-----KRISRQLASTLPAPLENAELCTQA-MALET 492
            P   P  PR +++P    P PPP +      + S QL    P  +  A   T   +A   
Sbjct: 1904 P-DFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPG 1962

Query: 493  PTPGPP 498
            P P PP
Sbjct: 1963 PAPSPP 1968



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 73/285 (25%), Positives = 96/285 (33%), Gaps = 48/285 (16%)

Query: 261 PLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPP--VP 318
           P  P S A  P++   PRR    PP  P  PC   Q  V+ A A A   P P  PP  VP
Sbjct: 203 PQAPRSRACEPST---PRRSRGRPPGRPAGPCRRKQQAVVVAEA-AVTIPKPEPPPPVVP 258

Query: 319 APHVT-----PHAPGP-PDHPNQPPMMTCERLPCPTAGLG---------PLREEAMKPGA 363
             H T        PGP P  P +    +         G G           R + +K G 
Sbjct: 259 VKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQ 318

Query: 364 ASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPE 423
            S  L+         +       P+RRV    S +  SP    +  +L        D  E
Sbjct: 319 LSLGLESGQGQGQHEESWQDV--PQRRVG---SGQGGSPCWKKQEQKL--------DDEE 365

Query: 424 DTPRESTE---QGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN 480
           +  +E  E   +G++ E +A     MP   +   + P PP            T PAP   
Sbjct: 366 EEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPP-----------LTPPAPSPP 414

Query: 481 AELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSP 525
             L   + +   P   PP    SP        PPAQ        P
Sbjct: 415 PPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPP 459



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 75/317 (23%), Positives = 105/317 (33%), Gaps = 49/317 (15%)

Query: 245  SALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPP-----PVLPLQPCSPAQPP- 298
            S+L    P +G+ P  P PP       + R +P  P PPP     P L   P     PP 
Sbjct: 1892 SSLTHHIPTVGD-PDFPAPPRR-----SRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPT 1945

Query: 299  -VLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTA----GLGP 353
             V+ AL P        +PP PAP   P     PD  +   +          A    G  P
Sbjct: 1946 SVVTALTPTSG---ELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEP 2002

Query: 354  LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSL 413
             +EE +  GA  S      +   P   +   + P  R          +PG+A        
Sbjct: 2003 FQEEIVAAGAMGS------SHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLA-------- 2048

Query: 414  PPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLAST 473
             P  T   P     +  + G D+E +A       + PR    PP  P   +      A  
Sbjct: 2049 -PSATPGAPRIEQLDGVDDGTDSEAEA------VQQPRGQGTPPSGPGVVRAGVLGAAGD 2101

Query: 474  LPAPLENAELCTQAMALET------PTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEF 527
               P E+         L+          GP  E   PA        P+Q    S + P  
Sbjct: 2102 RARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADP-- 2159

Query: 528  KGSLASLSDSLGVSVMA 544
              + A L  + GV V++
Sbjct: 2160 TRTFAWLPGAPGVRVLS 2176



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 67/285 (23%), Positives = 98/285 (34%), Gaps = 33/285 (11%)

Query: 193 PAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQP 252
           P  PP    P  P  SS RP    A      E  +         P        A   + P
Sbjct: 625 PPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPL--GAPEAPEPEPP 682

Query: 253 PLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLP 312
           P  + PA P P     T+  S       P   PV+     +   P   PAL+  P     
Sbjct: 683 PADDSPAEPEPRAVGRTNHLSL------PRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQ 736

Query: 313 TSPPVPA--PHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQ 370
              P+ A    + P A  PP    QPP         P+    P  E+A   G  S PL  
Sbjct: 737 LLQPLQALQTQLLPQALPPPQPQLQPP---------PSPQQMPPLEKARIAGVGSLPLSG 787

Query: 371 VPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPREST 430
           V       ++ + +   R +V      + Q   +AA    + L P G  +      ++ +
Sbjct: 788 V-------EEKMFSLLKRAKVQLFKIDQQQQQKVAA---SMPLSPGGQMEEVAGAVKQIS 837

Query: 431 EQGQDTEVKASDPHSMPELPR-TAKQPPVPPPRKKRISRQLASTL 474
           ++G    V++ D     +  R +  + PV  PR K + R  A  L
Sbjct: 838 DRG---PVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVAL 879



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 40/127 (31%), Positives = 50/127 (39%), Gaps = 9/127 (7%)

Query: 248  PTDQPPLGNCPARPLPPTSDATSPTSRWAP-RRPPPPPPVLPLQPCSPAQPPVLPALAPA 306
            P  +P  G+ P       S A      ++P RRP       PL   SP  P  L    P 
Sbjct: 1843 PPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLP--SPGSPSSLTHHIPT 1900

Query: 307  PACPLPTSPPVPAPHVTPHAP-GPPDHPNQPPMMTCE--RLPCPTA---GLGPLREEAMK 360
               P   +PP  +   +P AP  PP     PP+ T    R+P PT+    L P   E   
Sbjct: 1901 VGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAP 1960

Query: 361  PGAASSP 367
            PG A SP
Sbjct: 1961 PGPAPSP 1967



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 65/287 (22%), Positives = 94/287 (32%), Gaps = 47/287 (16%)

Query: 254  LGNCPARPLPPTSDATSPTSRW-------------APRRPPPPPPVLPLQPCSPAQPPVL 300
            +G+    P   + + +SPTSR+             AP   P  P +  L           
Sbjct: 2013 MGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEA 2072

Query: 301  PALA-PAPACPLPTSPPVPAPHVT----PHAPGPPDHPNQPPMMTCERLPCPTAGLGPLR 355
             A+  P      P+ P V    V       A  P D P++      + L  P  G    R
Sbjct: 2073 EAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPR 2132

Query: 356  EEAMKPGA----ASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQL 411
            EE++ P       S P Q + A P    +     P              +PG+      L
Sbjct: 2133 EESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPG-------------APGVRV----L 2175

Query: 412  SLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLA 471
            SL P      P  +      +     VK +       +P   KQPP+PP      +   +
Sbjct: 2176 SLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGE--PVPPPVKQPPLPPTISP--TAPTS 2231

Query: 472  STLP-APLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQA 517
             TLP  PL         + +  P P PP    +    +G   PP QA
Sbjct: 2232 WTLPPGPLLGV---LPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQA 2275


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 79/292 (27%), Positives = 106/292 (36%), Gaps = 40/292 (13%)

Query: 248  PTDQPPLGNCPARPLPPTSDATSPTSRWAPR-----RPPPPPPVLPLQPCSPAQP----P 298
            P+    LG  P+   P TS   SPT    P      RP   P   P  P + + P    P
Sbjct: 1071 PSSSSGLGTSPSSS-PRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1129

Query: 299  VLPALAPAPACPL-PTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPT----AGLGP 353
              P     PA PL P  PP P P   P  P PP  P  P   +  R P PT     G+G 
Sbjct: 1130 ATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPP---SGARSPAPTRKEFGGIGA 1186

Query: 354  LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSL 413
                   PG A   ++   +P    K N+  + P    S +  L    P   +       
Sbjct: 1187 ----PPSPGVARREMEAPKSPGTTRKDNIGRSQP----SPQAGLAGPGPAGYSTARPTIP 1238

Query: 414  PPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPP-VPPPRKKRISRQLAS 472
            P  G    P+   R S   G+ T      P S  +   T+K    +P P K + +    S
Sbjct: 1239 PRAGVISAPQSHARASA--GRLT------PESQSKTSETSKGSTFLPEPLKPQAAFPPQS 1290

Query: 473  TLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSS 524
            +LP P +  +     +A   P  GP      P  +   Q PP   ++HS  S
Sbjct: 1291 SLPPPAQRLQEPLVPVAAPMPQSGP-----QPNLETPPQPPPRSRSSHSLPS 1337



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 89/392 (22%), Positives = 140/392 (35%), Gaps = 82/392 (20%)

Query: 253  PLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPA---- 308
            P+   PA PLP       P     P+RPPPP PV P    +P Q P  P+ A +PA    
Sbjct: 1124 PIDAQPATPLPQKD----PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1179

Query: 309  ----CPLPTSPPV-----------------------PAPHVTPHAPGPPDH----PNQPP 337
                   P SP V                       P+P      PGP  +    P  PP
Sbjct: 1180 EFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1239

Query: 338  MM------------------------TCERLPCPTAGLGPLREEAMKPGAAS--SPLQQV 371
                                      T E     T    PL+ +A  P  +S   P Q++
Sbjct: 1240 RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1299

Query: 372  PAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTE 431
              P +P    +P + P+  +        +S    +   + S  PQ  ++G  D  RES  
Sbjct: 1300 QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPL 1359

Query: 432  QGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALE 491
            +    E  + +  ++ +   + +  PVP P  KR+  QL S   + + ++  C   M   
Sbjct: 1360 KIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLI-QLPSATQSNVLSSVSCMPTM--- 1415

Query: 492  TPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYS 551
                 PP   +S + +     P    T  ++++P      +  + + G    A  ++S +
Sbjct: 1416 -----PPIPARSQSQENMRSSPNPFITGLTRTNP-----FSDRTAAPGNPFRAKSEESEA 1465

Query: 552  TSSTEEELEQFSSPSVKKKPSMILGKARHRLS 583
            TS   +E     SP    +P   LG  + R S
Sbjct: 1466 TSWFSKEEPVTISPFPSLQP---LGHNKSRAS 1494



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 90/393 (22%), Positives = 123/393 (31%), Gaps = 102/393 (25%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPC--------SPA 295
            ++ LP   P     P RP PP   A  PT    P+RPPPP       P         +P 
Sbjct: 1130 ATPLPQKDPAQPLEPKRPPPPRPVA-PPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPP 1188

Query: 296  QPPVLPALAPAPACPLPT-----SPPVPAPHVTPHAPGPPDH----PNQPPMMTCERLP- 345
             P V      AP  P  T         P+P      PGP  +    P  PP       P 
Sbjct: 1189 SPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQ 1248

Query: 346  -CPTAGLGPLREEA-----------------MKPGAASSPLQQVPAP------------- 374
                A  G L  E+                 +KP AA  P   +P P             
Sbjct: 1249 SHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAA 1308

Query: 375  ------PLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTP-- 426
                  P P  +  P  PPR R S  +  E  S        Q  +   G SDG  ++P  
Sbjct: 1309 PMPQSGPQPNLETPPQPPPRSRSSHSLPSEASS--------QPQVKTNGISDGKRESPLK 1360

Query: 427  --------------RESTEQGQDTEVKASDPHSMPELPRTAK---------QPPVPPPRK 463
                           ++    Q + V   DP  + +LP   +          P +PP   
Sbjct: 1361 IDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMPTMPPIPA 1420

Query: 464  KRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAG-----------TQH 512
            +  S++   + P P       T   +  T  PG P   +S  S+A            +  
Sbjct: 1421 RSQSQENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRAKSEESEATSWFSKEEPVTISPF 1480

Query: 513  PPAQATAHSQSSPEFKGSLASLSDSLGVSVMAT 545
            P  Q   H++S      SL    DS  +   +T
Sbjct: 1481 PSLQPLGHNKS--RASSSLDGFKDSFDLQGQST 1511


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 79/292 (27%), Positives = 106/292 (36%), Gaps = 40/292 (13%)

Query: 248  PTDQPPLGNCPARPLPPTSDATSPTSRWAPR-----RPPPPPPVLPLQPCSPAQP----P 298
            P+    LG  P+   P TS   SPT    P      RP   P   P  P + + P    P
Sbjct: 1071 PSSSSGLGTSPSSS-PRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1129

Query: 299  VLPALAPAPACPL-PTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPT----AGLGP 353
              P     PA PL P  PP P P   P  P PP  P  P   +  R P PT     G+G 
Sbjct: 1130 ATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPP---SGARSPAPTRKEFGGIGA 1186

Query: 354  LREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSL 413
                   PG A   ++   +P    K N+  + P    S +  L    P   +       
Sbjct: 1187 ----PPSPGVARREMEAPKSPGTTRKDNIGRSQP----SPQAGLAGPGPAGYSTARPTIP 1238

Query: 414  PPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPP-VPPPRKKRISRQLAS 472
            P  G    P+   R S   G+ T      P S  +   T+K    +P P K + +    S
Sbjct: 1239 PRAGVISAPQSHARASA--GRLT------PESQSKTSETSKGSTFLPEPLKPQAAFPPQS 1290

Query: 473  TLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSS 524
            +LP P +  +     +A   P  GP      P  +   Q PP   ++HS  S
Sbjct: 1291 SLPPPAQRLQEPLVPVAAPMPQSGP-----QPNLETPPQPPPRSRSSHSLPS 1337



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 61/234 (26%), Positives = 80/234 (34%), Gaps = 46/234 (19%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPAL 303
            ++ LP   P     P RP PP   A  PT    P+RPPPP         S A+ P  P  
Sbjct: 1130 ATPLPQKDPAQPLEPKRPPPPRPVA-PPTRPAPPQRPPPP---------SGARSPA-PTR 1178

Query: 304  APAPACPLPTSPPVPAPHV-TPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPG 362
                    P SP V    +  P +PG     N          P P AGL         PG
Sbjct: 1179 KEFGGIGAPPSPGVARREMEAPKSPGTTRKDN-----IGRSQPSPQAGLA-------GPG 1226

Query: 363  AASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGD------------Q 410
             A         P +P +  + +AP     +    L  +S    +E              Q
Sbjct: 1227 PAG---YSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQ 1283

Query: 411  LSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKK 464
             + PPQ +   P    +E         V A  P S P+     + PP PPPR +
Sbjct: 1284 AAFPPQSSLPPPAQRLQEPL-----VPVAAPMPQSGPQ--PNLETPPQPPPRSR 1330


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 60/199 (30%), Positives = 69/199 (34%), Gaps = 18/199 (9%)

Query: 277  PRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQP 336
            P  PP  PP  P  P  P QPP LP L   P  P P S P   PH   HA GP   P   
Sbjct: 1277 PAPPPYLPPQQPSLPPPPQQPPPLPQLGSIP--PPPASAPPVGPHRHFHAHGPVPGPQHY 1334

Query: 337  PMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVS 396
             +    R P   AG  P             PL Q P  PLP     P  PP  +   +  
Sbjct: 1335 TLGRPGRAPRRGAGGHP-----QFAPHGRHPLHQ-PTSPLPLYSPAPQHPPAHKQGPKHF 1388

Query: 397  LEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQP 456
            +    P M        +P  G + GP   P   +            PHS   +P     P
Sbjct: 1389 IFSHHPQM--------MPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHS--PIPPHPSYP 1438

Query: 457  PVPPPRKKRISRQLASTLP 475
            P+PPP        L  T P
Sbjct: 1439 PLPPPSPHTPHSPLPPTSP 1457



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 33/83 (39%), Positives = 36/83 (43%), Gaps = 14/83 (16%)

Query: 262  LPPTSDATSPTSRWAPRRPP------PPPPVLPLQPCSPAQP-PVLPALAPAPACPLPTS 314
            +P    A  P SR     PP      P  P  PL P SP  P P  P L P P+   P S
Sbjct: 1397 MPAAGAAGGPGSR-----PPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL-PPPSPHTPHS 1450

Query: 315  P-PVPAPHVTPHAPGPPDHPNQP 336
            P P  +PH   HA GPP   N P
Sbjct: 1451 PLPPTSPHGPLHASGPPGTANPP 1473



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 37/135 (27%), Positives = 49/135 (36%), Gaps = 17/135 (12%)

Query: 386 PPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHS 445
           P   ++ +R S E Q    A     L L    T       P++S E+   TE     P  
Sbjct: 491 PGSAQLEKRESKEQQEDSSATSFSDLPLYLDDT------VPQQSPERLPSTE---PPPQG 541

Query: 446 MPELPRTAKQPPVPPP-----RKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPRE 500
            PE    A  PPVPPP     R+     +     P  LE  +   +A  L   T  PP +
Sbjct: 542 RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSD 601

Query: 501 GQ---SPASQAGTQH 512
                S  S  G+ H
Sbjct: 602 SSVDLSDRSDRGSVH 616


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 107/419 (25%), Positives = 147/419 (35%), Gaps = 58/419 (13%)

Query: 191  GKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTD 250
            G PA PP    P     S  RP   + +   E E  VG+  L     +      SAL   
Sbjct: 701  GPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST-LGSYATLTRRPGRSALVRT 759

Query: 251  QPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACP 310
             P +   PAR  P +        R  P  PPPP  +  +   SP  PP+  +  P     
Sbjct: 760  SPSVTPTPARGTPRSQSFALRARRKGPP-PPPPKRLSSVSGPSPEPPPLDESPGPKEGAT 818

Query: 311  LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCP--------TAGLG-PLREEA--- 358
             P    +  P      PGPP  P  P   T E  P P        ++G G P  EE    
Sbjct: 819  GPRRRTLSEPAGPSEPPGPP-APAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 877

Query: 359  --MKPGAASSPLQQVPAPP-----LPAKKNLPTAPP-RRRVSERVSLEDQSPGMAAEGDQ 410
               +P  A  P ++ P PP     L     +   P  R R   + +L       A  G  
Sbjct: 878  IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPA 937

Query: 411  LSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQL 470
              LP     + P   P  S  Q + + + A    + P  P  A QPPVPP     +    
Sbjct: 938  APLPSPTPGESP---PASSLPQPEPSSLPAQGVPT-PLAPSPAMQPPVPPCPGPGLESSA 993

Query: 471  AS----------------------TLPAPLENAELCTQAMALETPTPGP---PREGQSPA 505
            AS                      T P P+  A  CTQ +A   P   P   PR    P 
Sbjct: 994  ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVA--CTQ-LAFSGPKLAPRLGPRPVPPPR 1050

Query: 506  SQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSS 564
             ++     P QA    Q   +   SLA+   +   S+   +Q+   ++ST+  L+  S+
Sbjct: 1051 PESTGTVGPGQA---QQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDIST 1106



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 79/341 (23%), Positives = 107/341 (31%), Gaps = 81/341 (23%)

Query: 261 PLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAP 320
           P P   D + P  R  P     PP +    P     P V      +P+ P P  PP  AP
Sbjct: 635 PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAP-GPPPGAP 693

Query: 321 HVTPHAPGPPDHPNQPPMMTCE----RLPCPTAG-------------LGPLREEAMKPG- 362
               +  GPP  P  PP           P PT G             LG       +PG 
Sbjct: 694 WAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGR 753

Query: 363 --------------AASSPLQQV---------PAPPLPAKKNLPTAP------------- 386
                         A  +P  Q          P PP P + +  + P             
Sbjct: 754 SALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGP 813

Query: 387 ------PRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKA 440
                 PRRR     +   + PG  A     S   +    GPE TP      G+      
Sbjct: 814 KEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS-DTEEEEPGPEGTPPSRGSSGEGLPFAE 872

Query: 441 SDPHSMPELPRTAKQP----PVPP------PRKKRISRQLASTLPAPLENAELCTQAMAL 490
               ++ + P+ A  P    PVPP           + R+       PL+ A L   A  +
Sbjct: 873 EGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALL---AFGV 929

Query: 491 ETPTPGP------PREGQSPASQAGTQHPPAQATAHSQSSP 525
            + TPGP      P  G+SP + +  Q  P+   A    +P
Sbjct: 930 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTP 970



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 78/275 (28%), Positives = 97/275 (35%), Gaps = 54/275 (19%)

Query: 284 PPVLPLQPC-SPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQP-----P 337
           P  LPL P  SP+Q  +      A +     S   PAP  +   P PP   N P     P
Sbjct: 603 PEPLPLPPARSPSQESI-----GARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP 657

Query: 338 MMTCERLPCPTAGLGPLREEAMKP-GAASSPLQQVPAPPLPAK------KNLPTAPPRRR 390
              C  LP    G GP     M P G+ SSP    P PP  A          P  PP   
Sbjct: 658 PKLCSSLP----GQGPPPYVFMYPQGSPSSP---APGPPPGAPWAFSYLAGPPATPPDPP 710

Query: 391 VSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRES-----TEQGQDTEVKAS---- 441
             +R S     PG   EGD      +G ++GP  +   S        G+   V+ S    
Sbjct: 711 RPKRRSHSLSRPG-PTEGD-----AEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT 764

Query: 442 ------DPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENA----ELCTQAMALE 491
                  P S     R  ++ P PPP K+  S    S  P PL+ +    E  T      
Sbjct: 765 PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRT 824

Query: 492 TPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P  P E   P + AG    PA  T   +  PE
Sbjct: 825 LSEPAGPSEPPGPPAPAG----PASDTEEEEPGPE 855


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 107/419 (25%), Positives = 147/419 (35%), Gaps = 58/419 (13%)

Query: 191  GKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTD 250
            G PA PP    P     S  RP   + +   E E  VG+  L     +      SAL   
Sbjct: 783  GPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST-LGSYATLTRRPGRSALVRT 841

Query: 251  QPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACP 310
             P +   PAR  P +        R  P  PPPP  +  +   SP  PP+  +  P     
Sbjct: 842  SPSVTPTPARGTPRSQSFALRARRKGPP-PPPPKRLSSVSGPSPEPPPLDESPGPKEGAT 900

Query: 311  LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCP--------TAGLG-PLREEA--- 358
             P    +  P      PGPP  P  P   T E  P P        ++G G P  EE    
Sbjct: 901  GPRRRTLSEPAGPSEPPGPP-APAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 959

Query: 359  --MKPGAASSPLQQVPAPP-----LPAKKNLPTAPP-RRRVSERVSLEDQSPGMAAEGDQ 410
               +P  A  P ++ P PP     L     +   P  R R   + +L       A  G  
Sbjct: 960  IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPA 1019

Query: 411  LSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQL 470
              LP     + P   P  S  Q + + + A    + P  P  A QPPVPP     +    
Sbjct: 1020 APLPSPTPGESP---PASSLPQPEPSSLPAQGVPT-PLAPSPAMQPPVPPCPGPGLESSA 1075

Query: 471  AS----------------------TLPAPLENAELCTQAMALETPTPGP---PREGQSPA 505
            AS                      T P P+  A  CTQ +A   P   P   PR    P 
Sbjct: 1076 ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVA--CTQ-LAFSGPKLAPRLGPRPVPPPR 1132

Query: 506  SQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSS 564
             ++     P QA    Q   +   SLA+   +   S+   +Q+   ++ST+  L+  S+
Sbjct: 1133 PESTGTVGPGQA---QQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDIST 1188



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 79/341 (23%), Positives = 107/341 (31%), Gaps = 81/341 (23%)

Query: 261  PLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAP 320
            P P   D + P  R  P     PP +    P     P V      +P+ P P  PP  AP
Sbjct: 717  PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAP-GPPPGAP 775

Query: 321  HVTPHAPGPPDHPNQPPMMTCE----RLPCPTAG-------------LGPLREEAMKPG- 362
                +  GPP  P  PP           P PT G             LG       +PG 
Sbjct: 776  WAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGR 835

Query: 363  --------------AASSPLQQV---------PAPPLPAKKNLPTAP------------- 386
                          A  +P  Q          P PP P + +  + P             
Sbjct: 836  SALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGP 895

Query: 387  ------PRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKA 440
                  PRRR     +   + PG  A     S   +    GPE TP      G+      
Sbjct: 896  KEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS-DTEEEEPGPEGTPPSRGSSGEGLPFAE 954

Query: 441  SDPHSMPELPRTAKQP----PVPP------PRKKRISRQLASTLPAPLENAELCTQAMAL 490
                ++ + P+ A  P    PVPP           + R+       PL+ A L   A  +
Sbjct: 955  EGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALL---AFGV 1011

Query: 491  ETPTPGP------PREGQSPASQAGTQHPPAQATAHSQSSP 525
             + TPGP      P  G+SP + +  Q  P+   A    +P
Sbjct: 1012 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTP 1052



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 78/275 (28%), Positives = 97/275 (35%), Gaps = 54/275 (19%)

Query: 284 PPVLPLQPC-SPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQP-----P 337
           P  LPL P  SP+Q  +      A +     S   PAP  +   P PP   N P     P
Sbjct: 685 PEPLPLPPARSPSQESI-----GARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP 739

Query: 338 MMTCERLPCPTAGLGPLREEAMKP-GAASSPLQQVPAPPLPAK------KNLPTAPPRRR 390
              C  LP    G GP     M P G+ SSP    P PP  A          P  PP   
Sbjct: 740 PKLCSSLP----GQGPPPYVFMYPQGSPSSP---APGPPPGAPWAFSYLAGPPATPPDPP 792

Query: 391 VSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRES-----TEQGQDTEVKAS---- 441
             +R S     PG   EGD      +G ++GP  +   S        G+   V+ S    
Sbjct: 793 RPKRRSHSLSRPG-PTEGD-----AEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT 846

Query: 442 ------DPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENA----ELCTQAMALE 491
                  P S     R  ++ P PPP K+  S    S  P PL+ +    E  T      
Sbjct: 847 PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRT 906

Query: 492 TPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPE 526
              P  P E   P + AG    PA  T   +  PE
Sbjct: 907 LSEPAGPSEPPGPPAPAG----PASDTEEEEPGPE 937


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 70/302 (23%), Positives = 96/302 (31%), Gaps = 42/302 (13%)

Query: 249  TDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPA 308
            T  PP    P+ P+  T+     T+   P   P PP   P  P +    P  P   P+P 
Sbjct: 1445 TTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPP-PTTTPSPP 1503

Query: 309  CPLPTSPP----------VPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEA 358
               P +PP           P+P  T     PP     PP  T    P  T  L P    +
Sbjct: 1504 TTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPS 1563

Query: 359  MKPGAASS-PLQQVPAPPLPAKKNLPT------------APPRRRVSERVSLEDQSP--- 402
              P   ++ P    P+PP     + PT            +PP    +        SP   
Sbjct: 1564 PPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTT 1623

Query: 403  -GMAAEGDQLSLPPQGTSDGP---EDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPV 458
              +       +LPP  T   P     TP  +T     T    S P +    P     P  
Sbjct: 1624 TPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSS 1683

Query: 459  P------PPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQH 512
            P      PP     +  + +  P    ++ + T      T TP PP    +  S   T  
Sbjct: 1684 PITTTPSPP-----TTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPS 1738

Query: 513  PP 514
            PP
Sbjct: 1739 PP 1740



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 86/357 (24%), Positives = 115/357 (32%), Gaps = 46/357 (12%)

Query: 253  PLGNCPARPLPPTSDATSP---TSRWAPRRPP---------PPPPVLPLQPCSPAQPPVL 300
            P+  C   P PPT+  + P   T+   P   P         PPP   P  P +    P  
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPP- 1449

Query: 301  PALAPAPACPLPTSPP---VPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREE 357
            P   P+P     T+PP    P+P  T   P PP     PP  T    P PT    P    
Sbjct: 1450 PTTTPSPPISTTTTPPPTTTPSPPTT--TPSPPTTTPSPP-TTTTTTPPPTTTPSPPTTT 1506

Query: 358  AMKPGAASS--PLQQVPAPP-----LPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQ 410
             + P A+++  P    P+PP      P     P+ P    ++   S     P        
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP---- 1562

Query: 411  LSLPPQGTSDGPEDT----PRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-----PP 461
             S PP  T+  P  T    P  +T            P + P  P T    P P     PP
Sbjct: 1563 -SPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPP 1621

Query: 462  RKKRISRQLASTL--PAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATA 519
                I+   ++T   P    +    T      T TP PP           T  PP   T 
Sbjct: 1622 TTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTP 1681

Query: 520  HS----QSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPS 572
             S      SP           +   S + T     ST++        ++PS    PS
Sbjct: 1682 SSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPS 1738



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 62/259 (23%), Positives = 82/259 (31%), Gaps = 32/259 (12%)

Query: 237  PIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPP-----PPPPVLPLQP 291
            PI     ++ LP    P         PP +   SP +   P  P      PPP   P  P
Sbjct: 1546 PITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605

Query: 292  CSPAQPPVLPALAPAPACPLPTSPPVPA---PHVTPHAPGPPDHPNQPPMMTCERLPCPT 348
             +    P  P   P+P    P +PP      P  T  +P PP     PP  T    P  T
Sbjct: 1606 TTTTTTPP-PTTTPSPPTTTPITPPTSTTTLPPTTTPSP-PPTTTTTPPPTTTPSPPTTT 1663

Query: 349  AGLGPLREEAMKPGAA--SSPLQQVPAPP-----LPAKKNLPTAPPRRRVSERVSLEDQS 401
                P+      P     SSP+   P+PP      P+    P++P     +   +     
Sbjct: 1664 TPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSP 1723

Query: 402  PGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPP 461
            P           P   T+  P  TP   T     T        +   L  T   P + PP
Sbjct: 1724 P-----------PTTMTTPSPTTTPSPPT----TTMTTLPPTTTSSPLTTTPLPPSITPP 1768

Query: 462  RKKRISRQLASTLPAPLEN 480
                 S    +T   PL N
Sbjct: 1769 TFSPFSTTTPTTPCVPLCN 1787



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 70/319 (21%), Positives = 94/319 (29%), Gaps = 63/319 (19%)

Query: 248  PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAP 307
            PT  P        P P  +   +PT+          P   P    +P   P+       P
Sbjct: 4104 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4163

Query: 308  A-----CPLPTSPPV-------PAPHVTPHAPGPPDHPNQPPMMTCERL-PCPTAGLGPL 354
                     PT+ P+       P P  T    GPP H +  P+       P P +     
Sbjct: 4164 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQT 4223

Query: 355  REEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLP 414
                  P   S+ L     P +      P + P             +P   + G  LS P
Sbjct: 4224 SRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPT------------APTTTSGGHTLS-P 4270

Query: 415  PQGTSDGPEDTPRESTEQG----------QDTEVKA----SDPHSMPELPRTAKQPPVPP 460
            P  T+  P  TP   T  G          Q T   A      P S P + RT    P   
Sbjct: 4271 PPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLSTPSIIRTTGLRPY-- 4328

Query: 461  PRKKRISRQLASTLPAPLENA-----------ELCTQAMALE----------TPTPGPPR 499
            P    I   L  T  AP E               C+ +  LE          +PTP P +
Sbjct: 4329 PSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSK 4388

Query: 500  EGQSPASQAGTQHPPAQAT 518
               +P+  + T   P   T
Sbjct: 4389 STPTPSKPSSTPSKPTPGT 4407



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 65/302 (21%), Positives = 86/302 (28%), Gaps = 28/302 (9%)

Query: 248  PTDQPPLGNCPARPLP-PTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPA 306
            PT  P        P P PT   T  T+         P P     P     P   P     
Sbjct: 4012 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT----PTGTQTPTTTPITTTT 4067

Query: 307  PACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCP---TAGLGPLREEAMKPGA 363
               P PT      P  TP        P   P  T      P   T  + P          
Sbjct: 4068 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 4127

Query: 364  ASSPLQQ---VPAPPLPAKKNLPTAPPRRRVSERVSLED----QSPGMAAEGDQLSLPPQ 416
             ++P+     V   P P     PT  P    +           Q+P         ++ P 
Sbjct: 4128 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 4187

Query: 417  GTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVP-----------PPRKKR 465
             T  G +  P   T      E+  S+P      P+T++    P           PP  + 
Sbjct: 4188 PTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEM 4247

Query: 466  ISRQLASTLPAPLENAELCTQAMALETPT--PGPPREGQSPASQAGTQHPPAQATAHSQS 523
             S    ST  AP   +   T +    T T  PG P  G +  S +       Q T  S  
Sbjct: 4248 TSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAW 4307

Query: 524  SP 525
            +P
Sbjct: 4308 TP 4309


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 83/292 (28%), Positives = 108/292 (36%), Gaps = 64/292 (21%)

Query: 247 LPTDQPPLGNCP-----ARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLP 301
           +P   P LGN       AR  PP  +        AP  P PPPP  PL P  P+  P+  
Sbjct: 145 IPPASPRLGNTSEAHGAARTAPPRPNVP------APPPPTPPPPPPPLPPPLPSSSPIKT 198

Query: 302 ALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKP 361
            L   P      + PV AP V P AP PP  P  P        P P      L ++A+KP
Sbjct: 199 PLVSPPGPLTKGNLPVVAPPV-PCAPPPPPPPPPP-------TPPPLPPASVLSDKAVKP 250

Query: 362 GAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDG 421
             A  PL   P PP      LP  PP              PG+ AE    + P Q   + 
Sbjct: 251 QLA--PLHLPPIPP-----PLPLLPP-----------CGYPGLKAEP---ASPAQDAQEP 289

Query: 422 PEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENA 481
           P   P                P  +P +  +++ PP  PP+        + +  AP + A
Sbjct: 290 PAPPPPLPPYASCSPRASLPAP-PLPGVNSSSETPPPLPPK--------SPSFQAPPQKA 340

Query: 482 ELCTQAMALETPTPGPP---------REGQSPASQAGTQHPPAQATAHSQSS 524
                A AL  P P PP         R G+ P +  G  +PP    A S ++
Sbjct: 341 ----GAQALPAP-PAPPGSQPFLQKKRHGR-PGAGGGKLNPPPAPPARSPTT 386



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 97/360 (26%), Positives = 130/360 (36%), Gaps = 56/360 (15%)

Query: 186 PPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGND--RLWFVNPIFIEDC 243
           PP   G P  PP    P     SSLR        A   ++  G    ++  +N       
Sbjct: 14  PPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQI 73

Query: 244 SSALPTDQPPLGNCPAR--PLPPTSD----ATSPTSRWAPRRPPP------------PPP 285
            S+  T++   G+   R    PPT         P  R A +R               P P
Sbjct: 74  ESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSP 133

Query: 286 VLPLQPCS-PAQPPVLPAL-----APAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMM 339
            LP +  S P  PP  P L     A   A   P  P VPAP   P  P PP  P  PP+ 
Sbjct: 134 RLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAP--PPPTPPPPPPPLPPPLP 191

Query: 340 TCERLPCP-TAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLE 398
           +   +  P  +  GPL +  +   A   P    P PP P     P  PP   +S++    
Sbjct: 192 SSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP-PPPPTPPPLPPASVLSDKAVKP 250

Query: 399 DQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPV 458
             +P        L LPP      P   P          + + + P       + A++PP 
Sbjct: 251 QLAP--------LHLPPI-----PPPLPLLPPCGYPGLKAEPASP------AQDAQEPPA 291

Query: 459 -PPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREG--QSPASQAGTQHPPA 515
            PPP     S    ++LPAP     L     + ETP P PP+    Q+P  +AG Q  PA
Sbjct: 292 PPPPLPPYASCSPRASLPAP----PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPA 347



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 64/266 (24%), Positives = 84/266 (31%), Gaps = 37/266 (13%)

Query: 280 PPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGP-------PDH 332
           PPPPPP LP        PP  P  AP P  P P++PPV     +     P        D 
Sbjct: 4   PPPPPPPLP--------PPPPPLGAPPP--PPPSAPPVSTDTSSLRRADPKGRSALLADI 53

Query: 333 PNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPA---KKNLPTAPPRR 389
                +    ++   +A      +   K G  S+  +    PP          P   P  
Sbjct: 54  QQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAG 113

Query: 390 RVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPEL 449
           +         Q PG  A   +L   P  T  GP   P  S   G  +E   +   + P  
Sbjct: 114 QRDVAGGKTGQGPGSRAPSPRL---PNKTISGPL-IPPASPRLGNTSEAHGAARTAPPRP 169

Query: 450 PRTAKQPPVPPPRKKRISRQLASTL---------PAPLENAELCTQAMALETPTPGPPRE 500
              A  PP PPP    +   L S+          P PL    L   A  +    P PP  
Sbjct: 170 NVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP-- 227

Query: 501 GQSPASQAGTQHPPAQATAHSQSSPE 526
              P        PPA   +     P+
Sbjct: 228 --PPPPPTPPPLPPASVLSDKAVKPQ 251



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 39/142 (27%), Positives = 48/142 (33%), Gaps = 28/142 (19%)

Query: 246 ALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAP 305
           A P   PP  +C                  +PR   P PP LP    S   PP LP  +P
Sbjct: 291 APPPPLPPYASC------------------SPRASLPAPP-LPGVNSSSETPPPLPPKSP 331

Query: 306 APACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAAS 365
           +   P       P        P PP  P   P +  +R   P AG G L      P  A 
Sbjct: 332 SFQAP-------PQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPP--AR 382

Query: 366 SPLQQVPAPPLPAKKNLPTAPP 387
           SP  ++ +    A    PT  P
Sbjct: 383 SPTTELSSKSQQATAWTPTQQP 404


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 80/288 (27%), Positives = 104/288 (36%), Gaps = 31/288 (10%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRW-APRRPPPPPPVLPL--QPCSPAQPPVL 300
            ++A+PT + P    PA  +PP  + TSP +    P  P  P   +P   +P SPA     
Sbjct: 1017 AAAVPTPEEPTS--PAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPT 1074

Query: 301  P--ALAPAPACPLPTSPPVPAPHV-TPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREE 357
            P    +PA A P P  P  PA  V TP  P  P      P       P   A   P  EE
Sbjct: 1075 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP-----EEPASPAAAVPTPEE 1129

Query: 358  AMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQG 417
               P AA+ P  + PA P PA   +PT       +  V   ++S   AA    +  P + 
Sbjct: 1130 PASP-AAAVPTPEEPAFPAPA---VPTPEESASAAVAVPTPEESASPAA---AVPTPAES 1182

Query: 418  TS-DGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPA 476
             S      T  E T         A+   ++ E    A   P            LA+ +  
Sbjct: 1183 ASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPT-----SEEPASLAAAVSN 1237

Query: 477  PLENAELCTQAMALETPTPG-----PPREGQSPASQAGTQHPPAQATA 519
            P E          LE PT        P E  SPA+   T   PA   A
Sbjct: 1238 PEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAA 1285



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 83/332 (25%), Positives = 122/332 (36%), Gaps = 36/332 (10%)

Query: 262  LPPTSDATSPTSRWAPR---RPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVP 318
            +P T +  +P     P      P  P    ++  +P +P    A  P P  P   +  VP
Sbjct: 962  VPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVP 1021

Query: 319  APHVTPHAPG----PPDHPNQP--PMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVP 372
             P   P +P     PP+ P  P   + T E    P A + P  EE   P AA+ P  + P
Sbjct: 1022 TPE-EPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAV-PTPEEPTSP-AAAVPTPEEP 1078

Query: 373  APPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQ 432
              P  A    P  P     +     E  SP  A    +    P      PE+ P      
Sbjct: 1079 TSPAAAVPT-PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEE-PASPAAA 1136

Query: 433  GQDTEVKASDPHSMPELPRTAKQP-PVPPPRKKRISRQLASTLPAPLENAELCTQAMALE 491
                E  A    ++P    +A     VP P +   S   A+ +P P E+A        LE
Sbjct: 1137 VPTPEEPAFPAPAVPTPEESASAAVAVPTPEE---SASPAAAVPTPAESASFAAVVATLE 1193

Query: 492  TPT------PGPP------REGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSL- 538
             PT      P P        E  SPA+   T   PA   A + S+PE   S A+   +L 
Sbjct: 1194 EPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAA-AVSNPEEPTSPAAAVPTLE 1252

Query: 539  ----GVSVMATDQDSYSTSSTEEELEQFSSPS 566
                  + + T ++  S +++    E+ +SP+
Sbjct: 1253 EPTSSAAAVLTPEELSSPAASVPTPEEPASPA 1284



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 74/280 (26%), Positives = 102/280 (36%), Gaps = 36/280 (12%)

Query: 244  SSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPAL 303
            ++A+PT + P    PA  +P   + TSP +         P P  P  P +    P  PA 
Sbjct: 1069 AAAVPTPEEPTS--PAAAVPTPEEPTSPAA-------AVPTPEEPTSPAAAVPTPEEPA- 1118

Query: 304  APAPACPLPTSPPVPAPHV-TPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPG 362
            +PA A P P  P  PA  V TP  P  P     P + T E        + P  EE+  P 
Sbjct: 1119 SPAAAVPTPEEPASPAAAVPTPEEPAFP----APAVPTPEESASAAVAV-PTPEESASPA 1173

Query: 363  AASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQG--TSD 420
            AA      VP P   A      A      S   S+   +  M A  ++ + P     TS+
Sbjct: 1174 AA------VPTPAESASFAAVVATLEEPTSPAASVPTPA-AMVATLEEFTSPAASVPTSE 1226

Query: 421  GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN 480
             P       +   + T   A+ P    E P ++    + P   + +S   AS +P P E 
Sbjct: 1227 EPASLAAAVSNPEEPTSPAAAVP--TLEEPTSSAAAVLTP---EELSSPAAS-VPTPEEP 1280

Query: 481  AELCTQAMALETPTP-----GPPREGQSPASQAGTQHPPA 515
            A        LE P         P     PA+   T   PA
Sbjct: 1281 ASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPA 1320



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 32/106 (30%), Positives = 37/106 (34%), Gaps = 18/106 (16%)

Query: 237  PIFIEDCSSALPTDQPPLGNCPARPLP----PTSDATS-----PTSRWAPRRPPPPPPVL 287
            P   E  S A     P     PA  +P    PTS A +       S  A   P P  P  
Sbjct: 1223 PTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPAS 1282

Query: 288  PLQPCSPAQPPVLPALA---------PAPACPLPTSPPVPAPHVTP 324
            P    S  + P  PA A         PA + P P  P +PA  V P
Sbjct: 1283 PAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPP 1328



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 26/111 (23%), Positives = 40/111 (36%), Gaps = 8/111 (7%)

Query: 237  PIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPP------PVLPLQ 290
            P   E  SSA     P   + PA  +P   +  SP +  +    P  P      P +   
Sbjct: 1249 PTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAI 1308

Query: 291  PCSPAQPPVLPALAPAPACPLPTSPPVPAPH--VTPHAPGPPDHPNQPPMM 339
            P +    P +PA+  A   P+    P+  P   V+ H    P      P++
Sbjct: 1309 PAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPVL 1359


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 76/294 (25%), Positives = 104/294 (35%), Gaps = 37/294 (12%)

Query: 281 PPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMT 340
           P  PP+ P+ P  P   PV P  AP+P    P  PP P P V    P     P+  PM +
Sbjct: 633 PRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSV-GSMPSAGPMPSAGPMPS 691

Query: 341 CERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
               P P+A  GP    A   G +   L  VP   LP  +N                 ++
Sbjct: 692 AG--PVPSARPGP-PTTANHLGLSVPGLVSVPPRLLPGPENHRAG------------SNE 736

Query: 401 SPGMAAEG-DQLSLPPQGTSDGPEDTP---RESTEQGQDTEVKASD---------PHSMP 447
            P +A  G    ++PP  T  G    P       E+  D E+             P  +P
Sbjct: 737 DPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLP 796

Query: 448 ELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQ 507
            LP        PPP         +  +PA  E  EL      L  P P PP     P   
Sbjct: 797 PLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPP-----PVPG 851

Query: 508 AGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQ 561
             T  PP       + +P   G  A   D   +++ ++D++       EEE E+
Sbjct: 852 PVTLPPPQLV---PEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEE 902



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 47/139 (33%), Positives = 59/139 (42%), Gaps = 35/139 (25%)

Query: 215 HDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSR 274
           +D   A ++E+S+ +D          +D    +P   PPL      P PP S AT P   
Sbjct: 768 YDKEEASDVEISLESDS---------DDSVVIVPEGLPPL------PPPPPSGATPPPI- 811

Query: 275 WAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPN 334
            AP  PP   P +P    +  +P  LPA AP    PLP  PP P P      PGP   P 
Sbjct: 812 -APTGPPTASPPVP----AKEEPEELPA-APG---PLPPPPPPPPP-----VPGPVTLP- 856

Query: 335 QPPMMTCERLPCPTAGLGP 353
            PP +  E  P    G GP
Sbjct: 857 -PPQLVPEGTP---GGGGP 871



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 60/228 (26%), Positives = 79/228 (34%), Gaps = 45/228 (19%)

Query: 252 PPLGNCP-ARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACP 310
           P  G  P ARP PPT+      S   P     PP +LP      A     P LAP+   P
Sbjct: 690 PSAGPVPSARPGPPTTANHLGLS--VPGLVSVPPRLLPGPENHRAGSNEDPILAPS-GTP 746

Query: 311 LPTSPP------------------------------------VPAPHVTPHAPGPPDHPN 334
            PT PP                                    V  P   P  P PP    
Sbjct: 747 PPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGA 806

Query: 335 QPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSER 394
            PP +     P  +  + P +EE  +  AA  PL   P PP P    + T PP + V E 
Sbjct: 807 TPPPIAPTGPPTASPPV-PAKEEPEELPAAPGPLPPPPPPPPPVPGPV-TLPPPQLVPEG 864

Query: 395 VSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASD 442
                   G  A  + L++    +SD  E+   E  E+ ++ E +  D
Sbjct: 865 T---PGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEED 909



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 48/185 (25%), Positives = 63/185 (34%), Gaps = 37/185 (20%)

Query: 281  PPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMT 340
            PPPP + P  P   + P V P   P P   L    P      T    G    P   P   
Sbjct: 977  PPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEP-----GTEEERGADTAPTLAP--- 1028

Query: 341  CERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQ 400
             E LP      G +  E   P A          PP    +  P+APP     E    ED 
Sbjct: 1029 -EALP----SQGEVEREGESPAAG--------PPPQELVEEEPSAPPTLLEEE---TEDG 1072

Query: 401  SPGMAAEGDQLSLPPQGTSDGPEDTPRES----TEQGQDTEVKASDPHSMPELPRTAKQP 456
            S       D++  PP+  ++   +T  E+     ++  DT    +D    P  P   K P
Sbjct: 1073 S-------DKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCP--PDDEKPP 1123

Query: 457  PVPPP 461
            P   P
Sbjct: 1124 PPTEP 1128



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 45/178 (25%), Positives = 60/178 (33%), Gaps = 38/178 (21%)

Query: 261  PLPPTSDATSPTSRWAPR--RPPPPPPVLPLQPCSPAQ-----PPVLPALAPAPACPLPT 313
            P PPT     P     P+    P P P L L+   P           P LAP     LP+
Sbjct: 977  PPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE---ALPS 1033

Query: 314  SPPVPAPHVTPHAPGPP-----DHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPL 368
               V     +P A  PP     + P+ PP                L EE  + G  S  +
Sbjct: 1034 QGEVEREGESPAAGPPPQELVEEEPSAPP---------------TLLEEETEDG--SDKV 1076

Query: 369  QQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTP 426
            Q  P P  PA++ + T      + E+    +Q    A   D +  PP      P   P
Sbjct: 1077 Q--PPPETPAEEEMETETEAEALQEK----EQDDTAAMLADFIDCPPDDEKPPPPTEP 1128


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 62/257 (24%), Positives = 88/257 (34%), Gaps = 44/257 (17%)

Query: 247 LPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPA---- 302
           +P  +P +G+ P    PP      P       R  PP P  P QP     PP  P     
Sbjct: 169 MPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGT 228

Query: 303 ------------LAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERL-PCPTA 349
                        + +P    P  PP P+  +    P PP      P +  E + P P  
Sbjct: 229 ALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQ 288

Query: 350 GLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPR--------RRVSERVSLEDQS 401
              P      +P A+S   Q  P PP P++   P  PP         R     +SL   +
Sbjct: 289 NNKPPVPSTPRPSASS---QAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSST 345

Query: 402 PGMAAEGDQLSLPPQGTS------------DGPEDTPRESTEQGQDTEVKASDP----HS 445
           P + + G    LPP  +              GP   P   +  G  +    + P     S
Sbjct: 346 PPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405

Query: 446 MPELPRTAKQPPVPPPR 462
             + PR+  +PP+PP R
Sbjct: 406 GVDSPRSGPRPPLPPDR 422



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 61/214 (28%), Positives = 80/214 (37%), Gaps = 31/214 (14%)

Query: 253 PLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPC--SPAQPPVLPALAPAPACP 310
           P  N P  PLPPT       SR    +PPPPPP +  +P     A PP  P     P   
Sbjct: 245 PFSNRP--PLPPTP------SRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP--- 293

Query: 311 LPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQ 370
           +P++P   A    P  P PP  P  PP      LP  ++G         +  + SS    
Sbjct: 294 VPSTPRPSASSQAPPPPPPPSRPGPPP------LPPSSSGNDETPRLPQRNLSLSSSTPP 347

Query: 371 VPAP----PLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTP 426
           +P+P    PLP   +    PP R    R       P ++  G         TS     TP
Sbjct: 348 LPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGS--------TSRALPATP 399

Query: 427 RESTEQGQDTEVKASDPHSMPELPRTAKQPPVPP 460
           +  +  G D+      P   P+ P     PP PP
Sbjct: 400 QLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPP 433



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 84/314 (26%), Positives = 112/314 (35%), Gaps = 57/314 (18%)

Query: 187 PQERGKPAEP--PRDRAPGF--PLVSSLRPTAHDANCACEIELSVGNDRLWFVN-PIFIE 241
           P  RG P  P  PR  +PG   P     R TA       +  LS  +    F N P    
Sbjct: 198 PHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSP---FSNRPPLPP 254

Query: 242 DCSSAL----PTDQPPLGNCP-----ARPLPPTSD-----ATSPTSRWAPRRPPPPPPVL 287
             S AL    P   PP+GN P     A P PP  +      ++P    + + PPPPPP  
Sbjct: 255 TPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP-- 312

Query: 288 PLQPCSPAQPPVLPALAPAPACPL------PTSPPVPAPHVTPHAPGPPDHPNQPPMM-- 339
           P +P  P  PP        P  P        ++PP+P+P  +   P PP     PP+   
Sbjct: 313 PSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDP 372

Query: 340 --TCERLPCP--------TAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRR 389
                 LP P        T+   P   +        SP +  P PPLP  +    APP  
Sbjct: 373 PGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSP-RSGPRPPLPPDRPSAGAPPPP 431

Query: 390 RVSERVSLEDQSPGMAAEGDQ-------LSLPP-----QGTSDGPEDTPRESTEQGQDTE 437
             S  +    Q      E +          LPP     Q T   P    R  +  G +  
Sbjct: 432 PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRR 491

Query: 438 VKASDPHSMPELPR 451
            + + P  +P +PR
Sbjct: 492 ERGAPP--LPPIPR 503



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 79/340 (23%), Positives = 112/340 (32%), Gaps = 72/340 (21%)

Query: 252 PPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPL 311
           P LG      +P      +  +     RPP  PP        P  PP  P   P P+   
Sbjct: 98  PGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGH 157

Query: 312 PTSPPVP------------------APHVTPHAPGP----PDHPNQPPMMTCERLPCP-- 347
            + PP P                   P   P  P P    P +   PP+    R P P  
Sbjct: 158 RSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGP 217

Query: 348 -----------TAGLGPLREEAMKPGAASSPL-QQVPAPPLPAK----KNLPTAPPRRRV 391
                        G G +R+    P ++SSP   + P PP P++    K  P  PP   V
Sbjct: 218 TPPPFPGNRGTALGGGSIRQ---SPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP---V 271

Query: 392 SERVSLEDQ----------------SPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQD 435
             R S+  +                +P  +A       PP  +  GP   P  S+   + 
Sbjct: 272 GNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDET 331

Query: 436 TEV---KASDPHSMPELPRTAKQPPVPPPRKKRISRQL------ASTLPAPLENAELCTQ 486
             +     S   S P LP   +  P+PPP  +R    +      +  LP P   +   + 
Sbjct: 332 PRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGST 391

Query: 487 AMALETPTPGPPREG-QSPASQAGTQHPPAQATAHSQSSP 525
           + AL      P R G  SP S      PP + +A +   P
Sbjct: 392 SRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPP 431


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,778,418
Number of Sequences: 37866
Number of extensions: 2918538
Number of successful extensions: 51665
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 1844
Number of HSP's that attempted gapping in prelim test: 21502
Number of HSP's gapped (non-prelim): 14181
length of query: 985
length of database: 18,247,518
effective HSP length: 112
effective length of query: 873
effective length of database: 14,006,526
effective search space: 12227697198
effective search space used: 12227697198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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