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Search of human proteins with 38348304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348304 von Willebrand factor A domain containing 2 [Homo
sapiens]
(725 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa... 1459 0.0
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens] 168 1e-41
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens] 168 2e-41
gi|156616290 collagen type VI alpha 6 [Homo sapiens] 144 2e-34
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens] 132 1e-30
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens] 131 3e-30
gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens] 130 4e-30
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 130 6e-30
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 130 6e-30
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 130 6e-30
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 124 3e-28
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 119 1e-26
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 119 1e-26
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens] 117 3e-26
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens] 116 6e-26
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [... 115 1e-25
gi|89191868 von Willebrand factor preproprotein [Homo sapiens] 114 4e-25
gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo ... 110 6e-24
gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo ... 110 6e-24
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ... 107 3e-23
gi|21359974 vitrin [Homo sapiens] 103 7e-22
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens] 101 2e-21
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 100 8e-21
gi|205277471 cochlin precursor [Homo sapiens] 95 3e-19
gi|4758022 cochlin precursor [Homo sapiens] 95 3e-19
gi|11321565 matrilin 3 precursor [Homo sapiens] 93 8e-19
gi|40068485 von Willebrand factor A domain containing 1 isoform ... 83 1e-15
gi|31657142 integrin, alpha 1 precursor [Homo sapiens] 71 3e-12
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 71 3e-12
gi|148886654 polydom [Homo sapiens] 64 6e-10
>gi|38348304 von Willebrand factor A domain containing 2 [Homo
sapiens]
Length = 725
Score = 1459 bits (3778), Expect = 0.0
Identities = 725/725 (100%), Positives = 725/725 (100%)
Query: 1 MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSN 60
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSN
Sbjct: 1 MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSN 60
Query: 61 SVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKR 120
SVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKR
Sbjct: 61 SVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKR 120
Query: 121 MVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTV 180
MVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTV
Sbjct: 121 MVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTV 180
Query: 181 FAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAH 240
FAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAH
Sbjct: 181 FAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAH 240
Query: 241 PCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCD 300
PCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCD
Sbjct: 241 PCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCD 300
Query: 301 SQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFL 360
SQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFL
Sbjct: 301 SQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFL 360
Query: 361 RAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPT 420
RAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPT
Sbjct: 361 RAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPT 420
Query: 421 LTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGS 480
LTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGS
Sbjct: 421 LTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGS 480
Query: 481 EAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSA 540
EAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSA
Sbjct: 481 EAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSA 540
Query: 541 SVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQ 600
SVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQ
Sbjct: 541 SVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQ 600
Query: 601 APYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
APYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI
Sbjct: 601 APYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
Query: 661 SVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGGEWGNPHPQGCPH 720
SVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGGEWGNPHPQGCPH
Sbjct: 661 SVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGGEWGNPHPQGCPH 720
Query: 721 GRPSA 725
GRPSA
Sbjct: 721 GRPSA 725
>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
Length = 540
Score = 168 bits (426), Expect = 1e-41
Identities = 141/491 (28%), Positives = 216/491 (43%), Gaps = 55/491 (11%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++D S SV FE + F + + GL++ P RVG Q+SS FPL +FS
Sbjct: 33 LDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFS 92
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
+++++ I+ +V T T LA++Y ++ A VP++ +IVTDG+ Q
Sbjct: 93 RREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
VA + Q + RG+ ++AVGV+ L A+AS P +HV L E + F
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQE--FGLQFQ 210
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFL 284
S +C A C H C+H + G C L C
Sbjct: 211 SRLC--AIDYCSFGNHSCQHECVST----PGGPRCHCREGHDLQPDGRSCQ--------- 255
Query: 285 THPATCYRTTCPG---PCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECR 341
R C G C+ Q CV EGL Y+CLCP G + K CR
Sbjct: 256 ------VRDLCNGVDHGCEFQ-------CVSEGL-SYRCLCP--EGRQLQADGKSCNRCR 299
Query: 342 ---VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
VDL+ L+D S F K FV + V + RVG+ +S + P+G
Sbjct: 300 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 359
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPR-----RVVVLLT 453
Y ++ ++ + + T+TG ALR E F A RPR RV ++ T
Sbjct: 360 RYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGA---RPRALNVPRVGLVFT 416
Query: 454 ESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPK--HVMVYSDPQDLFNQI 510
+ S+D+++ A A+ +++ VG +AV AEL EI P HV D + + +
Sbjct: 417 DGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLL 476
Query: 511 PELQGKLCSRQ 521
L+G +C +
Sbjct: 477 ENLRGSICPEE 487
Score = 112 bits (279), Expect = 2e-24
Identities = 77/212 (36%), Positives = 109/212 (51%), Gaps = 11/212 (5%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
VD++ L+DGS SV +FE K F + D LD+SPE RVG QFSS EFPL +
Sbjct: 303 VDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYG 362
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
T EVK + + + T T LAL++++ + A +VP++ ++ TDG+SQ
Sbjct: 363 TAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 422
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
D+++ + + KE G+ ++AVGV EL +ASEP HV A T+ L L
Sbjct: 423 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTH-LLENLRG 481
Query: 225 SAICSSATPDCRVEAH-PCEHRTLEMVREFAG 255
S IC E PCE E + EF G
Sbjct: 482 S-ICPEEGISAGTELRSPCE---CESLVEFQG 509
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/185 (34%), Positives = 98/185 (52%), Gaps = 8/185 (4%)
Query: 512 ELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVG 571
+ GK C+R CR +DLV ++D S SV P+NF ++ FV +V+P+ T+VG
Sbjct: 289 QADGKSCNR----CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVG 344
Query: 572 LVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP- 630
LV + S+V+T F L T A + +A+ Y+ G AL H+ + + +GARP
Sbjct: 345 LVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPR 404
Query: 631 --GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHV 688
VP+ +V T GR +D +V A + + GI + VGVG + LR +A + +HV
Sbjct: 405 ALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIAS-EPAELHV 463
Query: 689 AAYAD 693
+ D
Sbjct: 464 SYAPD 468
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/162 (36%), Positives = 80/162 (49%), Gaps = 3/162 (1%)
Query: 523 PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTA 582
P C T LDLVF++D+S SV P F M+ F+ V P+ T+VG++ Y SQVQ+
Sbjct: 26 PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSV 85
Query: 583 FGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVL 639
F L R M RAI L G A+ + + +V GARP VP+ V++
Sbjct: 86 FPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIV 145
Query: 640 TGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP 681
T GR + A A + R GI + VGV LR +A P
Sbjct: 146 TDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASP 187
>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
Length = 581
Score = 168 bits (425), Expect = 2e-41
Identities = 148/509 (29%), Positives = 230/509 (45%), Gaps = 50/509 (9%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++D S SV FE + F + + GL++ P RVG Q+SS FPL +FS
Sbjct: 33 LDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFS 92
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
+++++ I+ +V T T LA++Y ++ A VP++ +IVTDG+ Q
Sbjct: 93 RREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
VA + Q + RG+ ++AVGV+ L A+AS P +HV L E + F
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQE--FGLQFQ 210
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAP----CWRGSRRTLAVLAAHCPF--YS 278
S +C A C H CEH + + + + R A+ +C F +S
Sbjct: 211 SRLC--AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAI--DYCSFGNHS 266
Query: 279 WKRVFLTHPATCYRTTCPGPCDSQP----CQ-----NG------GTCVPEGLDGYQCLCP 323
+ ++ P R C D QP CQ NG CV EGL Y+CLCP
Sbjct: 267 CQHECVSTPGG-PRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGL-SYRCLCP 324
Query: 324 LAFGGEANCALKLSLECR---VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRA 380
G + K CR VDL+ L+D S F K FV + V +
Sbjct: 325 --EGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGT 382
Query: 381 RVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRT 440
RVG+ +S + P+G Y ++ ++ + + T+TG ALR E F A
Sbjct: 383 RVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGA 442
Query: 441 GQDRPR-----RVVVLLTESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSP 494
RPR RV ++ T+ S+D+++ A A+ +++ VG +AV AEL EI P
Sbjct: 443 ---RPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEP 499
Query: 495 K--HVMVYSDPQDLFNQIPELQGKLCSRQ 521
HV D + + + L+G +C +
Sbjct: 500 AELHVSYAPDFGTMTHLLENLRGSICPEE 528
Score = 112 bits (279), Expect = 2e-24
Identities = 77/212 (36%), Positives = 109/212 (51%), Gaps = 11/212 (5%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
VD++ L+DGS SV +FE K F + D LD+SPE RVG QFSS EFPL +
Sbjct: 344 VDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYG 403
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
T EVK + + + T T LAL++++ + A +VP++ ++ TDG+SQ
Sbjct: 404 TAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 463
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
D+++ + + KE G+ ++AVGV EL +ASEP HV A T+ L L
Sbjct: 464 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTH-LLENLRG 522
Query: 225 SAICSSATPDCRVEAH-PCEHRTLEMVREFAG 255
S IC E PCE E + EF G
Sbjct: 523 S-ICPEEGISAGTELRSPCE---CESLVEFQG 550
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/185 (34%), Positives = 98/185 (52%), Gaps = 8/185 (4%)
Query: 512 ELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVG 571
+ GK C+R CR +DLV ++D S SV P+NF ++ FV +V+P+ T+VG
Sbjct: 330 QADGKSCNR----CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVG 385
Query: 572 LVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP- 630
LV + S+V+T F L T A + +A+ Y+ G AL H+ + + +GARP
Sbjct: 386 LVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPR 445
Query: 631 --GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHV 688
VP+ +V T GR +D +V A + + GI + VGVG + LR +A + +HV
Sbjct: 446 ALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIAS-EPAELHV 504
Query: 689 AAYAD 693
+ D
Sbjct: 505 SYAPD 509
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/162 (36%), Positives = 80/162 (49%), Gaps = 3/162 (1%)
Query: 523 PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTA 582
P C T LDLVF++D+S SV P F M+ F+ V P+ T+VG++ Y SQVQ+
Sbjct: 26 PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSV 85
Query: 583 FGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVL 639
F L R M RAI L G A+ + + +V GARP VP+ V++
Sbjct: 86 FPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIV 145
Query: 640 TGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP 681
T GR + A A + R GI + VGV LR +A P
Sbjct: 146 TDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASP 187
>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
Length = 2263
Score = 144 bits (364), Expect = 2e-34
Identities = 98/368 (26%), Positives = 180/368 (48%), Gaps = 11/368 (2%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D+ L+D S T F K F+ V + RVG Y+ + + +Y +
Sbjct: 436 DIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSN 495
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVA 462
DL +++ I GG T TG+AL + + G P +VVL T S+D +
Sbjct: 496 KQDLGKAIENIRQMGGNTNTGAALNFTLSLLQKAKKQRGNKVPCHLVVL-TNGMSKDSIL 554
Query: 463 GPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSD---PQDLFNQIPELQGKLC 518
PA R + + +G EA + +L EI G K V D +D+ NQ+ + ++C
Sbjct: 555 EPANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQ---EIC 611
Query: 519 SRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQ 578
+ + C+ D++F++D+S S+GPENF++M++F+++ + ++ PD Q+G+V +
Sbjct: 612 TEE--ACKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDI 669
Query: 579 VQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVV 638
+ F L+ +++ + AI Q ++G G+AL + + + +GARP + K +++
Sbjct: 670 NKEEFQLNRFMSQSDISNAIDQMAHIGQTTLTGSALSFV-SQYFSPTKGARPNIRKFLIL 728
Query: 639 LTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQ 698
+T G + PA LR G+ + VGV L ++G + + +V + L+ +
Sbjct: 729 ITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIE 788
Query: 699 DVLIEWLC 706
D L+ +C
Sbjct: 789 DDLVFGIC 796
Score = 131 bits (329), Expect = 3e-30
Identities = 100/370 (27%), Positives = 175/370 (47%), Gaps = 10/370 (2%)
Query: 332 CALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSREL 391
C + E + D++FL+DSS + F + K F+K V R ++GV +S
Sbjct: 611 CTEEACKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDIN 670
Query: 392 LVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVL 451
+ + D+ ++D + G TLTGSAL ++ + S T+ + R+ ++L
Sbjct: 671 KEEFQLNRFMSQSDISNAIDQMAHIGQTTLTGSALSFVSQ--YFSPTKGARPNIRKFLIL 728
Query: 452 LTESHSEDEVAGPARHARARELLLLGVGSEAVRA-ELEEITGSPKHVMVYSDPQDLFNQI 510
+T+ ++D V PA R +++ VG +LEEI+G P+ V Y + D+ +I
Sbjct: 729 ITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVF-YVENFDILQRI 787
Query: 511 PE-LQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQ 569
+ L +CS + R + LD+VF++D+S S+ + + M+ F+ + +V + +
Sbjct: 788 EDDLVFGICSPREECKRIEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVR 847
Query: 570 VGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR 629
G + Y + F LD T+ ++ + +GG A L D + T RG+R
Sbjct: 848 FGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGSTYTAEA-LGFSDHMFTEARGSR 906
Query: 630 --PGVPKAVVVLTGGRG--AEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSL 685
GVP+ ++V+T G A+ A+ LR+ GI VL VG+ L +AG D
Sbjct: 907 LNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKY 966
Query: 686 IHVAAYADLR 695
V + L+
Sbjct: 967 FFVETFGGLK 976
Score = 109 bits (273), Expect = 8e-24
Identities = 90/378 (23%), Positives = 170/378 (44%), Gaps = 12/378 (3%)
Query: 339 ECR----VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVA 394
EC+ +D++F++DSS D + K F+ V+ ++ R G Y+ + V
Sbjct: 801 ECKRIEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVL 860
Query: 395 VPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSA--TRTGQDRPRRVVVLL 452
+ ++ +++ L GG T T AL ++ F A +R + P+ ++V+
Sbjct: 861 FYLDDFGTKLEVISVLQNDQAMGGSTYTAEALG-FSDHMFTEARGSRLNKGVPQVLIVIT 919
Query: 453 T-ESHSEDEVAGPARHARARELLLLGVGSEAVR-AELEEITGSPKHVMVYSDPQDLFNQI 510
ESH D++ A+ R + +L+L VG + EL + GS L
Sbjct: 920 DGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFVETFGGLKGIF 979
Query: 511 PELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQV 570
++ +C+ + C +DLVF++D S S+ P +F +M+ F+ S F+V+ + ++
Sbjct: 980 SDVTASVCNSSKVDCEIDKVDLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRI 1039
Query: 571 GLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR- 629
G + F L T + I + G G AL + + G+R
Sbjct: 1040 GAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFGNTHIGAALREV-EHYFRPDMGSRI 1098
Query: 630 -PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHV 688
G P+ ++VLT G+ ++ A A+ LR+ GI + VG+G V + L ++ G + + V
Sbjct: 1099 NTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGIGDVDDQQLIQITGTAEKKLTV 1158
Query: 689 AAYADLRYHQDVLIEWLC 706
+ +L+ ++ +C
Sbjct: 1159 HNFDELKKVNKRIVRNIC 1176
Score = 109 bits (272), Expect = 1e-23
Identities = 96/387 (24%), Positives = 171/387 (44%), Gaps = 21/387 (5%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S + + F K F++ V A+ +++ RVG+ YS E V + +
Sbjct: 229 DVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGIN 288
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGS--ATRTGQDRPRRVVVLLTESHSEDE 460
+++ + + R G TG+A+++ + F + +R Q P+ + VL+T SED
Sbjct: 289 KSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGSRKNQGVPQ-IAVLVTHRDSEDN 347
Query: 461 VAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMV-----YSDP--------QDL 506
V A + R + + +G E A +LE+I P V ++D + L
Sbjct: 348 VTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAAHNQTFLKKL 407
Query: 507 FNQIPELQGKLCSRQ---RPGC-RTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFE 562
NQI R + GC T+ D+ ++D S S +F +M++F+ F
Sbjct: 408 RNQITHTVSVFSERTETLKSGCVDTEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFN 467
Query: 563 VNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVM 622
+ P +VG V Y F ++ + + +AI +GG + G AL +
Sbjct: 468 IAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIENIRQMGGNTNTGAALNFTLSLLQ 527
Query: 623 TVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPR 682
++ VP +VVLT G + PA +LR I V +G+ LR +AG
Sbjct: 528 KAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQLREIAGEE 587
Query: 683 DSLIHVAAYADLRYHQDVLIEWLCGGE 709
+ +V + L+ ++ +++ +C E
Sbjct: 588 KRVYYVHDFDALKDIRNQVVQEICTEE 614
Score = 105 bits (262), Expect = 1e-22
Identities = 55/139 (39%), Positives = 87/139 (62%), Gaps = 3/139 (2%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
VD++FL+DGS S+ F++ K F +V D+S RVR+GA QFS T H EFPL +F
Sbjct: 999 VDLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFI 1058
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLP--GGR-NASVPQILIIVTDGKSQGDV 166
++E+ +I+ + G T AL+ + H P G R N PQ+L+++TDG+SQ +V
Sbjct: 1059 GEKEISFQIENIKQIFGNTHIGAALREVEHYFRPDMGSRINTGTPQVLLVLTDGQSQDEV 1118
Query: 167 ALPSKQLKERGVTVFAVGV 185
A ++ L+ RG+ +++VG+
Sbjct: 1119 AQAAEALRHRGIDIYSVGI 1137
Score = 99.0 bits (245), Expect = 1e-20
Identities = 92/382 (24%), Positives = 172/382 (45%), Gaps = 20/382 (5%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS F K+F+ + + ++ E + RV +A YS +L + ++
Sbjct: 27 DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKG 86
Query: 403 -VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPR--RVVVLLTESHSED 459
P L F GG G AL Q A R + SA G+D+ + ++V+L S SED
Sbjct: 87 RSPMLNHLRKNFGFIGGSLQIGKAL-QEAHRTYFSAPANGRDKKQFPPILVVLASSESED 145
Query: 460 EVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYS-DPQDLFNQ-------- 509
V ++ R + ++ VG +A L+ + S H + + +F+Q
Sbjct: 146 NVEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKD 205
Query: 510 -IPELQGKLCSRQRPGCRTQAL-DLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDV 567
I +G + C+ ++ D+VF+LD S + ENF ++ F+ ++ +
Sbjct: 206 VIKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENC 265
Query: 568 TQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRG 627
+VGLV Y ++ + L ++ +L+ I G G A+ + +V + + G
Sbjct: 266 MRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNG 325
Query: 628 AR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PRDS 684
+R GVP+ V++T ++ A LR G+++ +G+ L ++A P +
Sbjct: 326 SRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQ 385
Query: 685 LI-HVAAYADLRYHQDVLIEWL 705
+ + +ADL H ++ L
Sbjct: 386 YVSKLKTFADLAAHNQTFLKKL 407
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 9/194 (4%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++D S S+ + K F I + D+ +VR GA +++ P + F LD F
Sbjct: 808 LDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFG 867
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLH--RGLPGGR-NASVPQILIIVTDGKSQGDV 166
T+ EV + ++ GG T T AL + H G R N VPQ+LI++TDG+S
Sbjct: 868 TKLEVISVLQNDQAMGGSTYTAEALGFSDHMFTEARGSRLNKGVPQVLIVITDGESHDAD 927
Query: 167 AL--PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
L +K L+++G+ V AVG+ EL A+A + + G+FS +++
Sbjct: 928 KLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFV---ETFGGLKGIFSDVTA 984
Query: 225 SAICSSATPDCRVE 238
S +C+S+ DC ++
Sbjct: 985 S-VCNSSKVDCEID 997
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/187 (28%), Positives = 94/187 (50%), Gaps = 3/187 (1%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI L+DGS S F K F V +I+P +VRVGA Q++ + LEF ++ +S
Sbjct: 436 DIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSN 495
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLH--RGLPGGRNASVPQILIIVTDGKSQGDVAL 168
+Q++ I+ + GG T T AL + L + R VP L+++T+G S+ +
Sbjct: 496 KQDLGKAIENIRQMGGNTNTGAALNFTLSLLQKAKKQRGNKVPCHLVVLTNGMSKDSILE 555
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALA-SEPRGQHVLLAEQVEDATNGLFSTLSSSAI 227
P+ +L+E + V+A+G++ +L +A E R +V + ++D N + + +
Sbjct: 556 PANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEICTEEA 615
Query: 228 CSSATPD 234
C D
Sbjct: 616 CKEMKAD 622
Score = 87.0 bits (214), Expect = 5e-17
Identities = 50/151 (33%), Positives = 81/151 (53%), Gaps = 1/151 (0%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DIMFL+D S S+G +F + K F + I P+RV++G QFS EF L+ F +
Sbjct: 622 DIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMS 681
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGLP-GGRNASVPQILIIVTDGKSQGDVALP 169
Q ++ I +M G T T AL ++ P G ++ + LI++TDG++Q V P
Sbjct: 682 QSDISNAIDQMAHIGQTTLTGSALSFVSQYFSPTKGARPNIRKFLILITDGEAQDIVKEP 741
Query: 170 SKQLKERGVTVFAVGVRFPRWEELHALASEP 200
+ L++ GV +++VGV +L ++ P
Sbjct: 742 AVVLRQEGVIIYSVGVFGSNVTQLEEISGRP 772
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FLLD S + + +F+ K F LDI +RVG +S+ + L
Sbjct: 229 DVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGIN 288
Query: 111 QQEVKARIKRMVFKGGRTETELALKYL---LHRGLPGGR-NASVPQILIIVTDGKSQGDV 166
+ EV I+ + + G+ T A+K L + G R N VPQI ++VT S+ +V
Sbjct: 289 KSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDNV 348
Query: 167 ALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHV 205
+ L+ GVT+F +G+ +L +AS P Q+V
Sbjct: 349 TKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYV 387
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 5/153 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+D S+ +G SF K F + L I ++ RV Q+S H EF L +F
Sbjct: 27 DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKG 86
Query: 111 QQEVKARI-KRMVFKGGRTETELALK--YLLHRGLP--GGRNASVPQILIIVTDGKSQGD 165
+ + + K F GG + AL+ + + P G P IL+++ +S+ +
Sbjct: 87 RSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDN 146
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALAS 198
V SK L++ GV + +VGV+ E L A+A+
Sbjct: 147 VEEASKALRKDGVKIISVGVQKASEENLKAMAT 179
Score = 44.7 bits (104), Expect = 3e-04
Identities = 84/379 (22%), Positives = 145/379 (38%), Gaps = 52/379 (13%)
Query: 339 ECRV---DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVG----VATYSREL 391
EC V +L+F LD S T F R K + VR + ++ VG + +Y+
Sbjct: 1750 ECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHA 1809
Query: 392 LVAVPVGEYQDVPDLVWSLDGIPFRGGPTLT--GSALRQAAERGFGSATRTGQDRPRRVV 449
V + L+ ++ IP+ G A+R + F T G R++
Sbjct: 1810 RHLVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVF-KRTLPGA-HTRKIA 1867
Query: 450 VLLTESHSED--EVAGPARHARARELLLLGVGSEAV----RAELEEITGSPKHVMVYSDP 503
+ S D + A A E++ + + V RA + TG+ + ++V S
Sbjct: 1868 TFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGA 1927
Query: 504 QDLFNQIPELQ-----------GKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQS 552
D + LQ C + RP +D F+LD S ++G F +++
Sbjct: 1928 -DYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIRA 1986
Query: 553 FVRSCALQFEVNPD----VT--QVGLVVYG----------SQVQTAFGLDTKPTRAAMLR 596
F+ + FE+ P+ VT +V L+ + S V+ F L T ++ M R
Sbjct: 1987 FLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKR 2046
Query: 597 AISQA-PYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGR----GAEDAAVP 651
+ ++ L G G AL D V R K + V++ G E
Sbjct: 2047 HVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRN--KVIFVISAGETSHLDGEILKKE 2104
Query: 652 AQKLRNNGISVLVVGVGPV 670
+ + + G ++ V +GP+
Sbjct: 2105 SLRAKCQGYALFVFSLGPI 2123
Score = 36.2 bits (82), Expect = 0.11
Identities = 43/183 (23%), Positives = 80/183 (43%), Gaps = 30/183 (16%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERV------RVGAFQFS------- 96
+D FLLD S ++G FE + F + D +I+PE RV +
Sbjct: 1964 MDAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPN 2023
Query: 97 ---STPHLEFPLDSFSTQQEVKARIKRMVFK-GGRTETELALKYLLHRGLPGGRNASVPQ 152
S EF L ++ +++ +K + V + G AL++ L N +
Sbjct: 2024 TQKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNK 2083
Query: 153 ILIIVTDGKS---QGDVALPSKQLKER----GVTVFAVGVRFPRWE--ELHALASEPRGQ 203
++ +++ G++ G++ L + L+ + + VF++G P W+ EL LAS P
Sbjct: 2084 VIFVISAGETSHLDGEI-LKKESLRAKCQGYALFVFSLG---PIWDDKELEDLASHPLDH 2139
Query: 204 HVL 206
H++
Sbjct: 2140 HLV 2142
Score = 32.7 bits (73), Expect = 1.2
Identities = 21/86 (24%), Positives = 35/86 (40%), Gaps = 4/86 (4%)
Query: 522 RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVG----LVVYGS 577
+P C +LVF LD S V + F +M+ + +V + VG ++ Y S
Sbjct: 1748 KPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNS 1807
Query: 578 QVQTAFGLDTKPTRAAMLRAISQAPY 603
+ ++ +LR I PY
Sbjct: 1808 HARHLVRFSDAYKKSQLLREIETIPY 1833
>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
Length = 499
Score = 132 bits (332), Expect = 1e-30
Identities = 113/401 (28%), Positives = 181/401 (45%), Gaps = 55/401 (13%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQ 401
+DL+F++DSS F + F+ +R + + RVGV YS ++ P+ +
Sbjct: 33 LDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFS 92
Query: 402 DVPDLVWSL-DGIPFRGGPTLTGSALRQAAERGFGSA--TRTGQDRPRRVVVLLTESHSE 458
D+ ++ D +P G T+TG A++ A F A R ++R RV V++T+ +
Sbjct: 93 RREDMERAIRDLVPLAQG-TMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151
Query: 459 DEVAGPARHARARELLLLGVGSEAVRAELEEITGSP---KHVMVYSD------------- 502
D VA A ARAR + + VG + SP +HV +
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQS 211
Query: 503 ---PQDLFNQIP------------------------ELQGKLCSRQRPGCRTQALDLVFM 535
+DL N + + GK C+R CR +DLV +
Sbjct: 212 RLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR----CREGHVDLVLL 267
Query: 536 LDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAML 595
+D S SV P+NF ++ FV +V+P+ T+VGLV + S+V+T F L T A +
Sbjct: 268 VDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVK 327
Query: 596 RAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVLTGGRGAEDAAVPA 652
+A+ Y+ G AL H+ + + +GARP VP+ +V T GR +D +V A
Sbjct: 328 QAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWA 387
Query: 653 QKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYAD 693
+ + GI + VGVG + LR +A + +HV+ D
Sbjct: 388 ARAKEEGIVMYAVGVGKAVEAELREIAS-EPAELHVSYAPD 427
Score = 125 bits (314), Expect = 1e-28
Identities = 128/487 (26%), Positives = 203/487 (41%), Gaps = 88/487 (18%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++D S SV FE + F + + GL++ P RVG Q+SS FPL +FS
Sbjct: 33 LDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFS 92
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
+++++ I+ +V T T LA++Y ++ A VP++ +IVTDG+ Q
Sbjct: 93 RREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
VA + Q + RG+ ++AVGV+ L A+AS P +HV L E + F
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQE--FGLQFQ 210
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFL 284
S +C C H CE + +
Sbjct: 211 SRLC--VRDLCNGVDHGCEFQCVS------------------------------------ 232
Query: 285 THPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRV-- 342
YR CP + + Q G +G+ L L G ++ L R
Sbjct: 233 --EGLSYRCLCP---EGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVN 287
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
++ LD S T +V + +F V +E R G A ++ ++AV EY +
Sbjct: 288 QIVDFLDVSPEGT-------RVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAV---EYME 337
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPR-----RVVVLLTESHS 457
RG T+TG ALR E F A RPR RV ++ T+ S
Sbjct: 338 -------------RG--TMTGLALRHMVEHSFSEAQGA---RPRALNVPRVGLVFTDGRS 379
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPK--HVMVYSDPQDLFNQIPELQ 514
+D+++ A A+ +++ VG +AV AEL EI P HV D + + + L+
Sbjct: 380 QDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLR 439
Query: 515 GKLCSRQ 521
G +C +
Sbjct: 440 GSICPEE 446
Score = 112 bits (279), Expect = 2e-24
Identities = 77/212 (36%), Positives = 109/212 (51%), Gaps = 11/212 (5%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
VD++ L+DGS SV +FE K F + D LD+SPE RVG QFSS EFPL +
Sbjct: 262 VDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYG 321
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
T EVK + + + T T LAL++++ + A +VP++ ++ TDG+SQ
Sbjct: 322 TAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 381
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
D+++ + + KE G+ ++AVGV EL +ASEP HV A T+ L L
Sbjct: 382 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTH-LLENLRG 440
Query: 225 SAICSSATPDCRVEAH-PCEHRTLEMVREFAG 255
S IC E PCE E + EF G
Sbjct: 441 S-ICPEEGISAGTELRSPCE---CESLVEFQG 468
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/162 (36%), Positives = 80/162 (49%), Gaps = 3/162 (1%)
Query: 523 PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTA 582
P C T LDLVF++D+S SV P F M+ F+ V P+ T+VG++ Y SQVQ+
Sbjct: 26 PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSV 85
Query: 583 FGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVL 639
F L R M RAI L G A+ + + +V GARP VP+ V++
Sbjct: 86 FPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIV 145
Query: 640 TGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP 681
T GR + A A + R GI + VGV LR +A P
Sbjct: 146 TDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASP 187
>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
Length = 496
Score = 131 bits (329), Expect = 3e-30
Identities = 113/414 (27%), Positives = 179/414 (43%), Gaps = 56/414 (13%)
Query: 321 LCPLAFGGEANCALKLSLECR--------VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRA 372
LC L +A C+ L+ + R DL+F++DSS F + KVF+ + + +
Sbjct: 11 LCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIES 70
Query: 373 VLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAER 432
+ + RVG+ Y+ + + + L+ ++ I T+TG A++ A +
Sbjct: 71 LDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITK 130
Query: 433 GFGSATRTGQDRP--RRVVVLLTESHSEDEVAGPARHARAR--ELLLLGVGSEAVRAELE 488
FG A P +VV+++T+ +D V + ARA EL +GVGS +A L
Sbjct: 131 AFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGS-VDKATLR 189
Query: 489 EITGSPK-----HVMVYSDPQDLFNQIPEL------------------------------ 513
+I P+ +V YS + L + E
Sbjct: 190 QIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCAC 249
Query: 514 --------QGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
GK C+ G + A DLVF++D S SV PENF ++ F+ +V+
Sbjct: 250 HEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSD 309
Query: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQ 625
+ QVGLV Y S V+ F L T+ + A+ Y+ G AL ++ D TV
Sbjct: 310 KLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVS 369
Query: 626 RGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
GARPG K +V T GR + A+K ++ G + VGVG + + LR +A
Sbjct: 370 SGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIA 423
Score = 130 bits (327), Expect = 4e-30
Identities = 127/491 (25%), Positives = 209/491 (42%), Gaps = 79/491 (16%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++F++D S SV FE+ K F V + LD+ P RVG ++ST EF L + +
Sbjct: 41 DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGL---PGGRNAS--VPQILIIVTDGKSQGD 165
+ + ++R+ T T LA+++ + + GGR+ S + +++I+VTDG+ Q
Sbjct: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSS 225
V S + + GV +FA+GV L +ASEP+ +HV E S
Sbjct: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEK--LSRKFQE 218
Query: 226 AICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLT 285
A C + C H CE +V ++
Sbjct: 219 AFC-VVSDLCATGDHDCE-------------------------------------QVCIS 240
Query: 286 HPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLL 345
P + TC C G T +G C + GG + A DL+
Sbjct: 241 SPGS---YTC-------ACHEGFTLNSDGK-----TCNVCSGGGGSSA--------TDLV 277
Query: 346 FLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPD 405
FL+D S + F K F+ + V + D A+VG+ YS + P+G + D
Sbjct: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337
Query: 406 LVWSLDGIPFRGGPTLTGSALRQAAERGF--GSATRTGQDRPRRVVVLLTESHSEDEVAG 463
+ ++ + + T+TG+AL+ + F S R G ++V ++ T+ S+D +
Sbjct: 338 IKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPG---AQKVGIVFTDGRSQDYIND 394
Query: 464 PARHARARELLLLGVG-SEAVRAELEEITGSP--KHVMVYSDPQDLFNQI-PELQGKLCS 519
A+ A+ + VG AV EL EI P +H +D + + NQI +LQ K+C
Sbjct: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTI-NQIGKKLQKKICV 453
Query: 520 RQRPGCRTQAL 530
+ P C ++L
Sbjct: 454 EEDP-CACESL 463
Score = 107 bits (268), Expect = 3e-23
Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S+A D++FL+DGS SV +FE K F + D LD+S + +VG Q+SS+ EFPL
Sbjct: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRG--LPGGRNASVPQILIIVTDGKSQG 164
F T++++KA ++ M + T T ALKYL+ + G ++ I+ TDG+SQ
Sbjct: 331 RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD 390
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQH 204
+ +K+ K+ G +FAVGV +EL +ASEP +H
Sbjct: 391 YINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEH 430
Score = 89.0 bits (219), Expect = 1e-17
Identities = 55/173 (31%), Positives = 92/173 (53%), Gaps = 5/173 (2%)
Query: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
CRT+ DLVF++D+S SV P F +++ F+ +V P+ T+VG+V Y S V+ F
Sbjct: 35 CRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFS 94
Query: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR---PGVPKAVVVLTG 641
L ++AA+L+A+ + L G A+ K G R P + K V+V+T
Sbjct: 95 LRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTD 154
Query: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PRDSLI-HVAAYA 692
GR + + + R +G+ + +GVG V LR++A P+D + +V +Y+
Sbjct: 155 GRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYS 207
>gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]
Length = 2526
Score = 130 bits (327), Expect = 4e-30
Identities = 101/371 (27%), Positives = 177/371 (47%), Gaps = 17/371 (4%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D+ FL+D S+ F + K F+ + RVGV YS + V + +Y +
Sbjct: 442 DIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSN 501
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALR---QAAERGFGSATRTGQDRPRRV---VVLLTESH 456
DL ++ I G T TG AL Q + G +DR +V +++LT+
Sbjct: 502 DIDLRKAIFNIKQLTGGTYTGKALDYILQIIKNGM-------KDRMSKVPCYLIVLTDGM 554
Query: 457 SEDEVAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V PA+ RA ++ + VG A + EL+EI G + V + L + E+
Sbjct: 555 STDRVVEPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVR 614
Query: 516 KLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
++C+ + GC D++F++D+S S+G ENF +M+ F+++ + ++ D TQ+G+V +
Sbjct: 615 EICAEK--GCEDMKADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQF 672
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKA 635
+ + F L+ T+ + AI + + G A L+ + T +GAR G K
Sbjct: 673 SDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTLTGKA-LNFVGQYFTHSKGARLGAKKF 731
Query: 636 VVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLR 695
++++T G +D PA+ LR +++ VGV L ++G + HV + L+
Sbjct: 732 LILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSSLVFHVENFDHLK 791
Query: 696 YHQDVLIEWLC 706
+ LI +C
Sbjct: 792 ALERKLIFRVC 802
Score = 120 bits (302), Expect = 3e-27
Identities = 99/383 (25%), Positives = 185/383 (48%), Gaps = 15/383 (3%)
Query: 332 CALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSREL 391
CA K + + D++FL+DSS + F + K+F+K + + + ++GV +S +
Sbjct: 617 CAEKGCEDMKADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKT 676
Query: 392 LVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVL 451
+ Y ++ ++D + TLTG AL + + + ++ + ++ ++L
Sbjct: 677 KEEFQLNRYFTQQEISDAIDRMSLINEGTLTGKALNFVGQ--YFTHSKGARLGAKKFLIL 734
Query: 452 LTESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQI 510
+T+ ++D+V PAR R +++ + VG A R++LEEI+G V + F+ +
Sbjct: 735 ITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSSLVFHVEN----FDHL 790
Query: 511 PELQGKLCSR--QRPGC-RTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDV 567
L+ KL R C R LD+VF+LD S S+ + M + + +V D
Sbjct: 791 KALERKLIFRVCALHDCKRITLLDVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDR 850
Query: 568 TQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRG 627
Q G + Y Q F L+T R+A++ + + GG AL H + + T + G
Sbjct: 851 VQFGALKYSDQPNILFYLNTYSNRSAIIENLRKRRDTGGNTYTAKALKHA-NALFTEEHG 909
Query: 628 AR--PGVPKAVVVLTGGRGAEDAAV--PAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRD 683
+R V + ++V+T G + + A +LRN GI++ VGVG + L +AG ++
Sbjct: 910 SRIKQNVKQMLIVITDGESHDHDQLNDTALELRNKGITIFAVGVGKANQKELEGMAGNKN 969
Query: 684 SLIHVAAYADLRYHQDVLIEWLC 706
+ I+V + L+ ++ E +C
Sbjct: 970 NTIYVDNFDKLKDVFTLVQERMC 992
Score = 106 bits (265), Expect = 7e-23
Identities = 95/403 (23%), Positives = 182/403 (45%), Gaps = 28/403 (6%)
Query: 329 EANCALKLSLECR----VDLLFLLDSSAGTTLDGFLR-AKVFVKRFVRAVLSEDSRARVG 383
+A+ + + C+ DL+FL+D S GT G LR + F++ ++ +++ R+G
Sbjct: 218 DADMQVHFPISCQKDSLADLVFLVDESLGT--GGNLRHLQTFLENITSSMDVKENCMRLG 275
Query: 384 VATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSA--TRTG 441
+ +YS + + + + + G + TG+A+ Q GF + +R
Sbjct: 276 LMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSRRA 335
Query: 442 QDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMV- 499
Q P+ + VL+T S+DEV A + R ++ + + + A +LEEI P +
Sbjct: 336 QGVPQ-IAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTIS 394
Query: 500 ----YSDPQDLFNQ-IPELQGKLCSR----------QRPGC-RTQALDLVFMLDTSASVG 543
Y+D + + + +LQ ++ S+ + GC T+ D+ F++D S+S+
Sbjct: 395 TLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADIHFLIDGSSSIQ 454
Query: 544 PENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPY 603
+ F Q++ F+ F + PD +VG+V Y + F + + +AI
Sbjct: 455 EKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRKAIFNIKQ 514
Query: 604 LGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVL 663
L G G AL +I + + VP ++VLT G + PA++LR I+V
Sbjct: 515 LTGGTYTGKALDYILQIIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAKRLRAEQITVH 574
Query: 664 VVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLC 706
VG+G L+ +AG + + + L+ ++ ++ +C
Sbjct: 575 AVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVREIC 617
Score = 100 bits (249), Expect = 5e-21
Identities = 88/354 (24%), Positives = 158/354 (44%), Gaps = 14/354 (3%)
Query: 342 VDLLFLLDSSAGTTL---DGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
+D++F+LD S D + + + + +A + D R + G YS + + +
Sbjct: 813 LDVVFVLDHSGSIKKQYQDHMINLTIHLVK--KADVGRD-RVQFGALKYSDQPNILFYLN 869
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLT--ESH 456
Y + ++ +L GG T T AL+ A + +++++++T ESH
Sbjct: 870 TYSNRSAIIENLRKRRDTGGNTYTAKALKHANALFTEEHGSRIKQNVKQMLIVITDGESH 929
Query: 457 SEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPEL-Q 514
D++ A R + + + VG +A + ELE + G+ K+ +Y D D + L Q
Sbjct: 930 DHDQLNDTALELRNKGITIFAVGVGKANQKELEGMAGN-KNNTIYVDNFDKLKDVFTLVQ 988
Query: 515 GKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVV 574
++C+ C Q D++F+ D S V +F M +F+ F++ ++G+
Sbjct: 989 ERMCTEAPEVCHLQEADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQ 1048
Query: 575 YGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR--PGV 632
+GS Q+ L T+ I GG AL + + + G R GV
Sbjct: 1049 FGSNYQSIIELKNSLTKTQWKTQIQNVSKSGGFPRIDFALKKV-SNMFNLHAGGRRNAGV 1107
Query: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLI 686
P+ +VV+T G D A + L++ GI VLV+G+G V E L + G + +I
Sbjct: 1108 PQTLVVITSGDPRYDVADAVKTLKDLGICVLVLGIGDVYKEHLLPITGNSEKII 1161
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI FL+DGS+S+ + FE+ K F + V + I P++VRVG Q+S +EF + +S
Sbjct: 442 DIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSN 501
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGLPG--GRNASVPQILIIVTDGKSQGDVAL 168
+++ I + G T T AL Y+L G R + VP LI++TDG S V
Sbjct: 502 DIDLRKAIFNIKQLTGGTYTGKALDYILQIIKNGMKDRMSKVPCYLIVLTDGMSTDRVVE 561
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASE 199
P+K+L+ +TV AVG+ EL +A +
Sbjct: 562 PAKRLRAEQITVHAVGIGAANKIELQEIAGK 592
Score = 83.2 bits (204), Expect = 8e-16
Identities = 93/392 (23%), Positives = 172/392 (43%), Gaps = 27/392 (6%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS F K F+ + + ++ E ++ RV +A YS E + ++
Sbjct: 30 DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89
Query: 403 -VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPR--RVVVLLTESHSED 459
P L F GG G AL Q A R + SA G+DR + ++V+L + SED
Sbjct: 90 RSPMLNHLKKNFQFIGGSLQIGKAL-QEAHRTYFSAPINGRDRKQFPPILVVLASAESED 148
Query: 460 EVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDL--FNQIPELQGK 516
EV ++ + + ++ VG +A L+ + S H + + +DL F+Q K
Sbjct: 149 EVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRT-IRDLSTFSQNMTQIIK 207
Query: 517 LCSRQRPG-------------CRTQAL-DLVFMLDTSASVGPENFAQMQSFVRSCALQFE 562
++ + G C+ +L DLVF++D S G N +Q+F+ + +
Sbjct: 208 DVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTG-GNLRHLQTFLENITSSMD 266
Query: 563 VNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVM 622
V + ++GL+ Y + +T L + T++ + I G + G A+ +
Sbjct: 267 VKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGF 326
Query: 623 TVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG 680
+ G+R GVP+ V++T ++ A LR ++V + + + L +
Sbjct: 327 SESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEIVS 386
Query: 681 --PRDSLIHVAAYADLRYHQDVLIEWLCGGEW 710
P ++ + +YADL + ++ L W
Sbjct: 387 YPPEQTISTLKSYADLETYSTKFLKKLQNEIW 418
Score = 81.6 bits (200), Expect = 2e-15
Identities = 51/153 (33%), Positives = 79/153 (51%), Gaps = 7/153 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DIMFL+D S S+G +F + K F + + I ++ ++G QFS EF L+ + T
Sbjct: 628 DIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFT 687
Query: 111 QQEVKARIKRMVFKGGRTETELAL----KYLLHRGLPGGRNASVPQILIIVTDGKSQGDV 166
QQE+ I RM T T AL +Y H G + LI++TDG +Q DV
Sbjct: 688 QQEISDAIDRMSLINEGTLTGKALNFVGQYFTH---SKGARLGAKKFLILITDGVAQDDV 744
Query: 167 ALPSKQLKERGVTVFAVGVRFPRWEELHALASE 199
P++ L+ + VT+F+VGV +L ++ +
Sbjct: 745 RDPARILRGKDVTIFSVGVYNANRSQLEEISGD 777
Score = 79.3 bits (194), Expect = 1e-14
Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 7/140 (5%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL DGS+ V F F + D DI +R+++G QF S L + T
Sbjct: 1005 DVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGSNYQSIIELKNSLT 1064
Query: 111 QQEVKARIKRMVFKGGRTETELALK-----YLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ + K +I+ + GG + ALK + LH G G RNA VPQ L+++T G + D
Sbjct: 1065 KTQWKTQIQNVSKSGGFPRIDFALKKVSNMFNLHAG--GRRNAGVPQTLVVITSGDPRYD 1122
Query: 166 VALPSKQLKERGVTVFAVGV 185
VA K LK+ G+ V +G+
Sbjct: 1123 VADAVKTLKDLGICVLVLGI 1142
Score = 77.4 bits (189), Expect = 4e-14
Identities = 57/198 (28%), Positives = 102/198 (51%), Gaps = 17/198 (8%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F+LD S S+ K + + I + D+ +RV+ GA ++S P++ F L+++S
Sbjct: 813 LDVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYS 872
Query: 110 TQQEVKARIKRMVFKGGRTETELALKY--LLHRGLPGGR-NASVPQILIIVTDGKSQ--- 163
+ + +++ GG T T ALK+ L G R +V Q+LI++TDG+S
Sbjct: 873 NRSAIIENLRKRRDTGGNTYTAKALKHANALFTEEHGSRIKQNVKQMLIVITDGESHDHD 932
Query: 164 --GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQ-HVLLAEQVEDATNGLFS 220
D AL +L+ +G+T+FAVGV +EL +A +V ++++D
Sbjct: 933 QLNDTAL---ELRNKGITIFAVGVGKANQKELEGMAGNKNNTIYVDNFDKLKDV-----F 984
Query: 221 TLSSSAICSSATPDCRVE 238
TL +C+ A C ++
Sbjct: 985 TLVQERMCTEAPEVCHLQ 1002
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/154 (30%), Positives = 77/154 (50%), Gaps = 7/154 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+D S+ +G SF K F + + L I + RV Q+S H EF L +F
Sbjct: 30 DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89
Query: 111 QQEVKARIKR-MVFKGGRTETELALKYLLHR-----GLPGGRNASVPQILIIVTDGKSQG 164
+ + +K+ F GG + AL+ HR + G P IL+++ +S+
Sbjct: 90 RSPMLNHLKKNFQFIGGSLQIGKALQE-AHRTYFSAPINGRDRKQFPPILVVLASAESED 148
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALAS 198
+V SK L++ GV + +VGV+ E L A+A+
Sbjct: 149 EVEEASKALQKDGVKIISVGVQKASEENLKAMAT 182
Score = 60.1 bits (144), Expect = 7e-09
Identities = 39/162 (24%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 521 QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQ 580
Q PG D+VF++D+S +GP++F +++F+ + + +V L Y +
Sbjct: 20 QSPGPGPVYADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFH 79
Query: 581 TAFGLDTKPTRAAMLRAISQ-APYLGGVGSAGTALLHIYDKVMT--VQRGARPGVPKAVV 637
+ F L T R+ ML + + ++GG G AL + + + R P +V
Sbjct: 80 SEFHLSTFKGRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILV 139
Query: 638 VLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
VL ++ ++ L+ +G+ ++ VGV E L+ +A
Sbjct: 140 VLASAESEDEVEEASKALQKDGVKIISVGVQKASEENLKAMA 181
Score = 59.7 bits (143), Expect = 9e-09
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 5/167 (2%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+D S G G+ + F + +D+ +R+G +S++ L S +T
Sbjct: 236 DLVFLVDESLGTG-GNLRHLQTFLENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTT 294
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGLP---GGRNA-SVPQILIIVTDGKSQGDV 166
Q E + +IK + + G++ T A+ + G G R A VPQI ++VT S +V
Sbjct: 295 QSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDEV 354
Query: 167 ALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVED 213
+ L+ V VFA+ ++ +L + S P Q + + D
Sbjct: 355 HDAALNLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTISTLKSYAD 401
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/180 (22%), Positives = 79/180 (43%), Gaps = 25/180 (13%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERV------RVGAFQFS------- 96
+D+ FL+D S VG F+ K F +V D I+P + RV +S
Sbjct: 2290 MDVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPN 2349
Query: 97 ---STPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQI 153
+LEF L ++++ ++K ++ G AL++ + G N ++
Sbjct: 2350 TEECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQWTIDNVFVGTPNLRKNKV 2409
Query: 154 LIIVTDGKSQG-------DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVL 206
+ +++ G++ +V+L +K + + VF+ G + +EL LAS P H++
Sbjct: 2410 IFVISAGETNSLDKDVLRNVSLRAK-CQGYSIFVFSFGPKH-NDKELEELASHPLDHHLV 2467
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/176 (20%), Positives = 76/176 (43%), Gaps = 19/176 (10%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERV------RVGAFQFS------- 96
+D++FL+D S ++ K F+ K +V D +I+ + + R+ +S
Sbjct: 1962 MDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFNIASDPLISDSGDRIALLSYSPWESSRR 2021
Query: 97 --STPHLEFPLDSFSTQQEVKARIKRMVFK-GGRTETELALKYLLHRGLPGGRNASVPQI 153
T EF ++ Q +K I+ + G AL + P ++
Sbjct: 2022 KMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWTTENLFPETPYLRKHKV 2081
Query: 154 LIIVTDGKS---QGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVL 206
+ +V+ G++ + V + + + K +G +F + + R +++ LAS P QH++
Sbjct: 2082 IFVVSAGENYERKEFVKMMALRAKCQGYVIFVISLGSTRKDDMEELASYPLDQHLI 2137
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 130 bits (326), Expect = 6e-30
Identities = 109/385 (28%), Positives = 178/385 (46%), Gaps = 26/385 (6%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS G DGF + FV R VR + S+ RVGV +S ++ + Y+
Sbjct: 1230 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 1289
Query: 403 VPDLVWSLDGIPFRGG-PTLTGSALRQAAERGF-GSATRTGQDRPRRVVVLLTESHSEDE 460
++ ++ + RGG P TG AL A F SA +D + +VL+ S+D+
Sbjct: 1290 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDD 1349
Query: 461 VAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCS 519
V+ A+ R+ ++ LGVG + R EL+ IT P+ V + F ++P ++ ++ +
Sbjct: 1350 VSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVRE----FRELPNIEERIMN 1405
Query: 520 RQRPGCRTQA----------------LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563
P T A D+VF+LD S + ++F ++ FV
Sbjct: 1406 SFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYE 1465
Query: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVM 622
+ D QVGLV Y S F L T+ ++ AI++ Y GG + L H+
Sbjct: 1466 DGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF 1525
Query: 623 TVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG 680
+ G+R VP+ V+TGG+ EDA + L G+ V VGV + SE + ++A
Sbjct: 1526 VPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIAS 1585
Query: 681 PRDSLIHVAAYADLRYHQDVLIEWL 705
+ V +L + ++E L
Sbjct: 1586 NSATAFRVGNVQELSELSEQVLETL 1610
Score = 110 bits (274), Expect = 6e-24
Identities = 94/349 (26%), Positives = 160/349 (45%), Gaps = 32/349 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S T F F+ + + + RVGV +S E + Y
Sbjct: 36 DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
++ ++ + F GG G AL E F TR G R +V+VL++ S
Sbjct: 96 KAQVLGAVKALGFAGGELANIGLALDFVVENHF---TRAGGSRVEEGVPQVLVLISAGPS 152
Query: 458 EDEVAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
DE+ + + G+G++A RAEL+ I +V++ P+ F +LQ K
Sbjct: 153 SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDN--LVFTVPE--FRSFGDLQEK 208
Query: 517 LCS-----RQR------PGCRTQAL-----DLVFMLDTSASVGPENFAQMQSFVRSCALQ 560
L QR P TQ + D+VF++D S+++G NF ++ F+ +
Sbjct: 209 LLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
Query: 561 FEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAI-SQAPYLGGVGSAGTALLHIYD 619
E+ D+ QV + Y V+ F +T PT+ ++ A+ P G G+AL + +
Sbjct: 269 LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
Query: 620 KVMTVQRG--ARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666
+ T G A G+PK +V++TGG+ ++ + PAQ+L+ + I +G
Sbjct: 329 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIG 377
Score = 110 bits (274), Expect = 6e-24
Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S+ L F + F+ + ++ + +V VA Y+ + +
Sbjct: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
Query: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459
+++ ++ + P G TGSAL F S+ R + P+ ++VL+T S D
Sbjct: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 357
Query: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516
E++ PA+ + ++ +G++ A +AELEEI V + ++ L +P L
Sbjct: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 417
Query: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
L + P + D++F+LD SA+VG NF ++ FV + ++ D +VGLV +
Sbjct: 418 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 477
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632
T F L+T T++ +L + Q GG G + G+AL ++Y T G+ R V
Sbjct: 478 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 537
Query: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
P+ +++LT G+ + A L GI VG L ++A
Sbjct: 538 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 584
Score = 100 bits (250), Expect = 4e-21
Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E + D+LFL D SA + F + F+ + + + + R+ VA YS ++ V
Sbjct: 627 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456
E+Q P+++ + + + G L G AL A F SA +D + +VLL
Sbjct: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745
Query: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V GPA + + ++ + A AELE+I SP ++ + + P++
Sbjct: 746 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 805
Query: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573
L S P + D+VF+LD S V F ++ FV+ +V D +V +V
Sbjct: 806 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 864
Query: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630
Y + + F L++ + ++ A+ Q LGG + G AL + ++ G+R
Sbjct: 865 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 924
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690
GVP+ ++VLT R +D P+ ++ G + +G+G ++ ++ D + +
Sbjct: 925 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 984
Query: 691 YADLRYHQDVLIE 703
+ L Q V+ E
Sbjct: 985 FRQLGTVQQVISE 997
Score = 99.0 bits (245), Expect = 1e-20
Identities = 91/350 (26%), Positives = 161/350 (46%), Gaps = 34/350 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S + F + ++R V + RV V +S + V + +
Sbjct: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
++ ++ + +GG + G+AL R +R GS G + +VL++ S
Sbjct: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 1142
Query: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517
+DEV PA + + + A + EL +I+ SP++V S F ++P L+ KL
Sbjct: 1143 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVST----FRELPSLEQKL 1198
Query: 518 CSR------------------QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCAL 559
+ P + A D+VF++D+S V P+ FA ++ FV
Sbjct: 1199 LTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVR 1258
Query: 560 QFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIY 618
+ + P +VG+V + + V F L T ++A +L AI + GG + G AL +
Sbjct: 1259 RLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVA 1318
Query: 619 DKVMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666
+ G+R GVP+ +V++ GG+ +D + AQ +R++GI L VG
Sbjct: 1319 RNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVG 1368
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS +VGK +F + F + + + LDI + +RVG QFS TP EF L+++ T
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165
+ ++ ++++ +GG T + L+ Y H GG VPQ+L+++T G+S+
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
+ L G+ F VG EL +A P
Sbjct: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 587
Score = 90.9 bits (224), Expect = 4e-18
Identities = 79/253 (31%), Positives = 125/253 (49%), Gaps = 18/253 (7%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS + + SF+ F + D + + ++VG Q++S P EF L FST
Sbjct: 1433 DIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFST 1492
Query: 111 QQEVKARIKRMVFKGGR-TETELALKYL-LHRGLP--GGR-NASVPQILIIVTDGKSQGD 165
++++ I ++V+KGGR T++ L++L ++ +P G R + VPQI ++T GKS D
Sbjct: 1493 KRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVED 1552
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALAS-EPRGQHVLLAEQVEDATNGLFSTLSS 224
S L +RGV VFAVGVR EE+ +AS V +++ + + + TL
Sbjct: 1553 AQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETL-H 1611
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFL 284
A+ + P A C L+++ F G+ R V A F S L
Sbjct: 1612 DAMHETLCPGVTDAAKAC---NLDVILGFDGS--------RDQNVFVAQKGFESKVDAIL 1660
Query: 285 THPATCYRTTCPG 297
+ +R +C G
Sbjct: 1661 NRISQMHRVSCSG 1673
Score = 88.2 bits (217), Expect = 2e-17
Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD SA F + FV V ++ + RVG+ +S + + YQ
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
D++ L + +GG L TGSAL F T G R R ++++LLT S
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 549
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
ED A +L VG S+A +AELE+I +P V + D F+ +P L +
Sbjct: 550 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 605
Query: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
L + P + ++ D++F+ D SA++ + F ++ F+ + V P
Sbjct: 606 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 664
Query: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624
+ T++ + Y V+ D ++ +L + + G + G AL + +
Sbjct: 665 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 724
Query: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
G+R GV + +V+L GR ++ PA L+ +G+
Sbjct: 725 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 762
Score = 87.0 bits (214), Expect = 5e-17
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S G GF K FV+R V ++ R RV V YS + Y +
Sbjct: 823 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
Query: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
D+V ++ + GGPT TG+A LR GS G +++++LT S
Sbjct: 882 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 938
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501
D+V P+ + + +G+G A E++ I+ G+ + V+
Sbjct: 939 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 998
Query: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
Q ++ LQ L PG + D+VF++D S S GPE F +++ +
Sbjct: 999 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 1056
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620
+V D T+V ++ + + F L+ ++ + A+ + GG + G AL ++
Sbjct: 1057 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1116
Query: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665
+ G+R GVP+ +V+++ G+ ++ PA +L+ G++ +
Sbjct: 1117 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163
Score = 84.0 bits (206), Expect = 5e-16
Identities = 50/156 (32%), Positives = 83/156 (53%), Gaps = 5/156 (3%)
Query: 49 AVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSF 108
+ DI+FL+DGSN+ G +F F + + + L I +++RVG QFS P F LD++
Sbjct: 34 SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
Query: 109 STQQEVKARIKRMVFKGGR-TETELALKYLL--HRGLPGGRNA--SVPQILIIVTDGKSQ 163
ST+ +V +K + F GG LAL +++ H GG VPQ+L++++ G S
Sbjct: 94 STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
Query: 164 GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASE 199
++ LK+ V F +G + EL +A++
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 189
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLDGS V G F K F V + LD+ +RVRV Q+S EF L+
Sbjct: 819 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
Query: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161
S+ +Q+V ++++ GG T T AL+++L L G R VPQ+LI++T +
Sbjct: 878 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937
Query: 162 SQGDVALPSKQLKERGVTVFAVGV 185
S DV PS +K G +G+
Sbjct: 938 SGDDVRNPSVVVKRGGAVPIGIGI 961
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S G F+ + + D LD+ + RV QFS P +EF L++ S+
Sbjct: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
Query: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ EV+ ++R+ KGGR E + + R L VPQ L++++ GKS +
Sbjct: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
V P+ +LK+ GV F + R EEL ++ P
Sbjct: 1146 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/160 (34%), Positives = 82/160 (51%), Gaps = 5/160 (3%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S A DI+FL+D S V F + F + L+I P +VRVG QFS+ EF L
Sbjct: 1226 SDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLK 1285
Query: 107 SFSTQQEVKARIKRMVFKGGR-TETELALKYL---LHRGLPGGR-NASVPQILIIVTDGK 161
++ +Q V I+R+ +GG T AL+++ L G R VPQ L++V GK
Sbjct: 1286 TYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGK 1345
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPR 201
SQ DV+ ++ ++ G+ VG R EL + ++PR
Sbjct: 1346 SQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR 1385
Score = 74.7 bits (182), Expect = 3e-13
Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 23/184 (12%)
Query: 19 PPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVC 78
PP++ Q + V+K DI+FL+DGS+++G +F + F V
Sbjct: 225 PPTIVTQVIEVNKR------------------DIVFLVDGSSALGLANFNAIRDFIAKVI 266
Query: 79 DGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRM-VFKGGRTETELALKYL 137
L+I + ++V Q++ T EF ++ T++EV +++M G T AL ++
Sbjct: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
Query: 138 ---LHRGLPGGRNA-SVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEEL 193
L G R A +P++L+++T GKS +++ P+++LK + FA+G + EL
Sbjct: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
Query: 194 HALA 197
+A
Sbjct: 387 EEIA 390
Score = 63.9 bits (154), Expect = 5e-10
Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 521 QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQ 580
Q+ + D++F++D S + G NFA + F+ + + + +VG+V + + +
Sbjct: 26 QQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPR 85
Query: 581 TAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--PGVPKAVV 637
T F LDT T+A +L A+ + GG + + G AL + + T G+R GVP+ +V
Sbjct: 86 TMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLV 145
Query: 638 VLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVA 689
+++ G +++ V+ + V S GL A R L H+A
Sbjct: 146 LISAGPSSDEIR----------YGVVALKQASVFSFGLGAQAASRAELQHIA 187
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL DGS ++ G F + F + D L++ PE R+ Q+S +E D +
Sbjct: 631 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
Query: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ E+ +KRM K G+ + A +Y+ + V Q L+++ G+S
Sbjct: 690 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 749
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211
V P+ LK+ GV F + EL + P +L AE +
Sbjct: 750 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 793
Score = 35.0 bits (79), Expect = 0.25
Identities = 90/432 (20%), Positives = 159/432 (36%), Gaps = 76/432 (17%)
Query: 296 PGPCDSQPCQNGGTCVPEG--LDGYQCLCPLAFGGEANCALKLSLECRV---DLLFLLDS 350
PGP P N G + + + + CP +G LEC V +L F LD+
Sbjct: 2155 PGPAG--PKGNRGDSIDQCALIQSIKDKCPCCYG---------PLECPVFPTELAFALDT 2203
Query: 351 SAGTTLDGFLRAKVFVKRFVRAVLSEDSR----ARVGVATYSRELLVAVPVGEYQDVPDL 406
S G D F R + V V + +S ARV V TY+ E+ + + + L
Sbjct: 2204 SEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVL 2263
Query: 407 VWSLDG--IPFRGGPTLTGSALRQAAERGFGSATRTG----------QDRPRRVVVLLTE 454
+ + + +A+ A F R G + P R L E
Sbjct: 2264 LDKIKNLQVALTSKQQSLETAMSFVARNTF-KRVRNGFLMRKVAVFFSNTPTRASPQLRE 2322
Query: 455 SHSEDEVAG--PARHARARELLLLG--------VGSEAVRAELEEITGSPKHVMVYSDPQ 504
+ + AG P R + L+ VG V ++T ++V+
Sbjct: 2323 AVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCL 2382
Query: 505 DLFNQIPELQGKLCSRQRPGCRTQA-------LDLVFMLDTSASVGPENFAQMQSFVRSC 557
D+ N P RP R + +D+ F+LD++ + F +M+ ++
Sbjct: 2383 DICNIDPSCG---FGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYL 2439
Query: 558 ALQFEVNPD------VTQVGLVVYGSQ----------VQTAFGLDTKPTRAAMLRAISQA 601
Q +++PD +V +V + V+ F L ++ ++ +S+
Sbjct: 2440 VRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRG 2499
Query: 602 -PYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKL----R 656
L G + G+A+ + + V + P K VV++ G E AQ++ +
Sbjct: 2500 MTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAK 2557
Query: 657 NNGISVLVVGVG 668
G +V+G+G
Sbjct: 2558 CKGYFFVVLGIG 2569
Score = 33.5 bits (75), Expect = 0.71
Identities = 17/78 (21%), Positives = 36/78 (46%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEY 400
+ D++FLLD S D F FV V V + +VG+ Y+ + + ++
Sbjct: 1431 KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDF 1490
Query: 401 QDVPDLVWSLDGIPFRGG 418
++ +++ + ++GG
Sbjct: 1491 STKRQIIDAINKVVYKGG 1508
Score = 32.0 bits (71), Expect = 2.1
Identities = 43/179 (24%), Positives = 71/179 (39%), Gaps = 26/179 (14%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAV-LSEDSR-----ARVGVATYSRE----- 390
+D+ F+LDS+ TTL F K ++ VR + +S D + ARV V ++
Sbjct: 2412 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2471
Query: 391 -----LLVAVPVGEYQDVPDLVWSLD-GIPFRGGPTLTGSALRQAAERGFGSATRTGQDR 444
+ V + +Y LV L G+ G GSA+ E F SA R
Sbjct: 2472 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAP---NPR 2528
Query: 445 PRRVVVLLTESHSEDEVAGPARH------ARARELLLLGVGSEAVRAELEEITGSPKHV 497
++VVL+ ++ A+ + ++LG+G + E+ P V
Sbjct: 2529 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDV 2587
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 130 bits (326), Expect = 6e-30
Identities = 109/385 (28%), Positives = 178/385 (46%), Gaps = 26/385 (6%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS G DGF + FV R VR + S+ RVGV +S ++ + Y+
Sbjct: 1436 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 1495
Query: 403 VPDLVWSLDGIPFRGG-PTLTGSALRQAAERGF-GSATRTGQDRPRRVVVLLTESHSEDE 460
++ ++ + RGG P TG AL A F SA +D + +VL+ S+D+
Sbjct: 1496 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDD 1555
Query: 461 VAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCS 519
V+ A+ R+ ++ LGVG + R EL+ IT P+ V + F ++P ++ ++ +
Sbjct: 1556 VSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVRE----FRELPNIEERIMN 1611
Query: 520 RQRPGCRTQA----------------LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563
P T A D+VF+LD S + ++F ++ FV
Sbjct: 1612 SFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYE 1671
Query: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVM 622
+ D QVGLV Y S F L T+ ++ AI++ Y GG + L H+
Sbjct: 1672 DGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF 1731
Query: 623 TVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG 680
+ G+R VP+ V+TGG+ EDA + L G+ V VGV + SE + ++A
Sbjct: 1732 VPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIAS 1791
Query: 681 PRDSLIHVAAYADLRYHQDVLIEWL 705
+ V +L + ++E L
Sbjct: 1792 NSATAFRVGNVQELSELSEQVLETL 1816
Score = 111 bits (277), Expect = 3e-24
Identities = 95/364 (26%), Positives = 165/364 (45%), Gaps = 32/364 (8%)
Query: 328 GEANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATY 387
G+ ++ + D++FL+D S T F F+ + + + RVGV +
Sbjct: 227 GDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQF 286
Query: 388 SRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGFGSATRTGQDRPR 446
S E + Y ++ ++ + F GG G AL E F TR G R
Sbjct: 287 SDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHF---TRAGGSRVE 343
Query: 447 ----RVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYS 501
+V+VL++ S DE+ + + G+G++A RAEL+ I +V++
Sbjct: 344 EGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDN--LVFT 401
Query: 502 DPQDLFNQIPELQGKLCS-----RQR------PGCRTQAL-----DLVFMLDTSASVGPE 545
P+ F +LQ KL QR P TQ + D+VF++D S+++G
Sbjct: 402 VPE--FRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLA 459
Query: 546 NFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAI-SQAPYL 604
NF ++ F+ + E+ D+ QV + Y V+ F +T PT+ ++ A+ P
Sbjct: 460 NFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLD 519
Query: 605 GGVGSAGTALLHIYDKVMTVQRG--ARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISV 662
G G+AL + + + T G A G+PK +V++TGG+ ++ + PAQ+L+ + I
Sbjct: 520 GSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMA 579
Query: 663 LVVG 666
+G
Sbjct: 580 FAIG 583
Score = 110 bits (274), Expect = 6e-24
Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S+ L F + F+ + ++ + +V VA Y+ + +
Sbjct: 445 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 504
Query: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459
+++ ++ + P G TGSAL F S+ R + P+ ++VL+T S D
Sbjct: 505 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 563
Query: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516
E++ PA+ + ++ +G++ A +AELEEI V + ++ L +P L
Sbjct: 564 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 623
Query: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
L + P + D++F+LD SA+VG NF ++ FV + ++ D +VGLV +
Sbjct: 624 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 683
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632
T F L+T T++ +L + Q GG G + G+AL ++Y T G+ R V
Sbjct: 684 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 743
Query: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
P+ +++LT G+ + A L GI VG L ++A
Sbjct: 744 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 790
Score = 107 bits (267), Expect = 4e-23
Identities = 65/185 (35%), Positives = 97/185 (52%), Gaps = 7/185 (3%)
Query: 48 AAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDS 107
AA DI+FL+D S ++G+ F+ + F V L + QF+ PH EF L++
Sbjct: 36 AAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNT 95
Query: 108 FSTQQEVKARIKRMVFKGGRTETELALKYLL--HRGLPGGRNA--SVPQILIIVTDGKSQ 163
+ T+QEV + I M + GG +T L+Y++ H G A VPQ+++++TDG S+
Sbjct: 96 YRTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSK 155
Query: 164 GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAE---QVEDATNGLFS 220
+ALPS +LK V VFA+GV L +ASEP H+ E + D L S
Sbjct: 156 DGLALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVS 215
Query: 221 TLSSS 225
+ SS
Sbjct: 216 CVHSS 220
Score = 100 bits (250), Expect = 4e-21
Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E + D+LFL D SA + F + F+ + + + + R+ VA YS ++ V
Sbjct: 833 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 891
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456
E+Q P+++ + + + G L G AL A F SA +D + +VLL
Sbjct: 892 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 951
Query: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V GPA + + ++ + A AELE+I SP ++ + + P++
Sbjct: 952 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 1011
Query: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573
L S P + D+VF+LD S V F ++ FV+ +V D +V +V
Sbjct: 1012 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 1070
Query: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630
Y + + F L++ + ++ A+ Q LGG + G AL + ++ G+R
Sbjct: 1071 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 1130
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690
GVP+ ++VLT R +D P+ ++ G + +G+G ++ ++ D + +
Sbjct: 1131 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 1190
Query: 691 YADLRYHQDVLIE 703
+ L Q V+ E
Sbjct: 1191 FRQLGTVQQVISE 1203
Score = 99.0 bits (245), Expect = 1e-20
Identities = 91/350 (26%), Positives = 161/350 (46%), Gaps = 34/350 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S + F + ++R V + RV V +S + V + +
Sbjct: 1233 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1291
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
++ ++ + +GG + G+AL R +R GS G + +VL++ S
Sbjct: 1292 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 1348
Query: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517
+DEV PA + + + A + EL +I+ SP++V S F ++P L+ KL
Sbjct: 1349 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVST----FRELPSLEQKL 1404
Query: 518 CSR------------------QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCAL 559
+ P + A D+VF++D+S V P+ FA ++ FV
Sbjct: 1405 LTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVR 1464
Query: 560 QFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIY 618
+ + P +VG+V + + V F L T ++A +L AI + GG + G AL +
Sbjct: 1465 RLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVA 1524
Query: 619 DKVMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666
+ G+R GVP+ +V++ GG+ +D + AQ +R++GI L VG
Sbjct: 1525 RNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVG 1574
Score = 97.4 bits (241), Expect = 4e-20
Identities = 85/368 (23%), Positives = 169/368 (45%), Gaps = 34/368 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS + F + F+ V+++ ++ + ++ + Y+
Sbjct: 39 DIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRT 98
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSA--TRTGQDRPRRVVVLLTESHSEDE 460
+++ + + + GG TG L + A +R G P+ V+V+LT+ HS+D
Sbjct: 99 KQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGDGVPQ-VIVVLTDGHSKDG 157
Query: 461 VAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCS 519
+A P+ ++ ++ + +G E A L+EI P ++ +++ + F + ++ G L S
Sbjct: 158 LALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFN--LENFTSLHDIVGNLVS 215
Query: 520 -------RQRPG--------CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVN 564
+R G + D++F++D S + G NFA + F+ + + +
Sbjct: 216 CVHSSVSPERAGDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIG 275
Query: 565 PDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMT 623
+VG+V + + +T F LDT T+A +L A+ + GG + + G AL + + T
Sbjct: 276 TQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFT 335
Query: 624 VQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP 681
G+R GVP+ +V+++ G +++ V+ + V S GL A
Sbjct: 336 RAGGSRVEEGVPQVLVLISAGPSSDEIR----------YGVVALKQASVFSFGLGAQAAS 385
Query: 682 RDSLIHVA 689
R L H+A
Sbjct: 386 RAELQHIA 393
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS +VGK +F + F + + + LDI + +RVG QFS TP EF L+++ T
Sbjct: 639 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 698
Query: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165
+ ++ ++++ +GG T + L+ Y H GG VPQ+L+++T G+S+
Sbjct: 699 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 758
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
+ L G+ F VG EL +A P
Sbjct: 759 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 793
Score = 90.9 bits (224), Expect = 4e-18
Identities = 79/253 (31%), Positives = 125/253 (49%), Gaps = 18/253 (7%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS + + SF+ F + D + + ++VG Q++S P EF L FST
Sbjct: 1639 DIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFST 1698
Query: 111 QQEVKARIKRMVFKGGR-TETELALKYL-LHRGLP--GGR-NASVPQILIIVTDGKSQGD 165
++++ I ++V+KGGR T++ L++L ++ +P G R + VPQI ++T GKS D
Sbjct: 1699 KRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVED 1758
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALAS-EPRGQHVLLAEQVEDATNGLFSTLSS 224
S L +RGV VFAVGVR EE+ +AS V +++ + + + TL
Sbjct: 1759 AQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETL-H 1817
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFL 284
A+ + P A C L+++ F G+ R V A F S L
Sbjct: 1818 DAMHETLCPGVTDAAKAC---NLDVILGFDGS--------RDQNVFVAQKGFESKVDAIL 1866
Query: 285 THPATCYRTTCPG 297
+ +R +C G
Sbjct: 1867 NRISQMHRVSCSG 1879
Score = 88.2 bits (217), Expect = 2e-17
Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD SA F + FV V ++ + RVG+ +S + + YQ
Sbjct: 639 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 698
Query: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
D++ L + +GG L TGSAL F T G R R ++++LLT S
Sbjct: 699 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 755
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
ED A +L VG S+A +AELE+I +P V + D F+ +P L +
Sbjct: 756 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 811
Query: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
L + P + ++ D++F+ D SA++ + F ++ F+ + V P
Sbjct: 812 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 870
Query: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624
+ T++ + Y V+ D ++ +L + + G + G AL + +
Sbjct: 871 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 930
Query: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
G+R GV + +V+L GR ++ PA L+ +G+
Sbjct: 931 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 968
Score = 87.0 bits (214), Expect = 5e-17
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S G GF K FV+R V ++ R RV V YS + Y +
Sbjct: 1029 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 1087
Query: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
D+V ++ + GGPT TG+A LR GS G +++++LT S
Sbjct: 1088 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 1144
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501
D+V P+ + + +G+G A E++ I+ G+ + V+
Sbjct: 1145 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 1204
Query: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
Q ++ LQ L PG + D+VF++D S S GPE F +++ +
Sbjct: 1205 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 1262
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620
+V D T+V ++ + + F L+ ++ + A+ + GG + G AL ++
Sbjct: 1263 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1322
Query: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665
+ G+R GVP+ +V+++ G+ ++ PA +L+ G++ +
Sbjct: 1323 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1369
Score = 84.0 bits (206), Expect = 5e-16
Identities = 50/156 (32%), Positives = 83/156 (53%), Gaps = 5/156 (3%)
Query: 49 AVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSF 108
+ DI+FL+DGSN+ G +F F + + + L I +++RVG QFS P F LD++
Sbjct: 240 SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 299
Query: 109 STQQEVKARIKRMVFKGGR-TETELALKYLL--HRGLPGGRNA--SVPQILIIVTDGKSQ 163
ST+ +V +K + F GG LAL +++ H GG VPQ+L++++ G S
Sbjct: 300 STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 359
Query: 164 GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASE 199
++ LK+ V F +G + EL +A++
Sbjct: 360 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 395
Score = 79.7 bits (195), Expect = 9e-15
Identities = 45/153 (29%), Positives = 78/153 (50%), Gaps = 2/153 (1%)
Query: 529 ALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTK 588
A D++F++D+S ++G E+F ++ F+ V + LV + T F L+T
Sbjct: 37 AADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTY 96
Query: 589 PTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR--PGVPKAVVVLTGGRGAE 646
T+ +L IS Y+GG G L +I +T G+R GVP+ +VVLT G +
Sbjct: 97 RTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKD 156
Query: 647 DAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
A+P+ +L++ ++V +GV L+ +A
Sbjct: 157 GLALPSAELKSADVNVFAIGVEDADEGALKEIA 189
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLDGS V G F K F V + LD+ +RVRV Q+S EF L+
Sbjct: 1025 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 1083
Query: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161
S+ +Q+V ++++ GG T T AL+++L L G R VPQ+LI++T +
Sbjct: 1084 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 1143
Query: 162 SQGDVALPSKQLKERGVTVFAVGV 185
S DV PS +K G +G+
Sbjct: 1144 SGDDVRNPSVVVKRGGAVPIGIGI 1167
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S G F+ + + D LD+ + RV QFS P +EF L++ S+
Sbjct: 1233 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1291
Query: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ EV+ ++R+ KGGR E + + R L VPQ L++++ GKS +
Sbjct: 1292 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1351
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
V P+ +LK+ GV F + R EEL ++ P
Sbjct: 1352 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1385
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/160 (34%), Positives = 82/160 (51%), Gaps = 5/160 (3%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S A DI+FL+D S V F + F + L+I P +VRVG QFS+ EF L
Sbjct: 1432 SDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLK 1491
Query: 107 SFSTQQEVKARIKRMVFKGGR-TETELALKYL---LHRGLPGGR-NASVPQILIIVTDGK 161
++ +Q V I+R+ +GG T AL+++ L G R VPQ L++V GK
Sbjct: 1492 TYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGK 1551
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPR 201
SQ DV+ ++ ++ G+ VG R EL + ++PR
Sbjct: 1552 SQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR 1591
Score = 74.7 bits (182), Expect = 3e-13
Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 23/184 (12%)
Query: 19 PPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVC 78
PP++ Q + V+K DI+FL+DGS+++G +F + F V
Sbjct: 431 PPTIVTQVIEVNKR------------------DIVFLVDGSSALGLANFNAIRDFIAKVI 472
Query: 79 DGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRM-VFKGGRTETELALKYL 137
L+I + ++V Q++ T EF ++ T++EV +++M G T AL ++
Sbjct: 473 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 532
Query: 138 ---LHRGLPGGRNA-SVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEEL 193
L G R A +P++L+++T GKS +++ P+++LK + FA+G + EL
Sbjct: 533 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 592
Query: 194 HALA 197
+A
Sbjct: 593 EEIA 596
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL DGS ++ G F + F + D L++ PE R+ Q+S +E D +
Sbjct: 837 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 895
Query: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ E+ +KRM K G+ + A +Y+ + V Q L+++ G+S
Sbjct: 896 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 955
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211
V P+ LK+ GV F + EL + P +L AE +
Sbjct: 956 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 999
Score = 35.0 bits (79), Expect = 0.25
Identities = 90/432 (20%), Positives = 159/432 (36%), Gaps = 76/432 (17%)
Query: 296 PGPCDSQPCQNGGTCVPEG--LDGYQCLCPLAFGGEANCALKLSLECRV---DLLFLLDS 350
PGP P N G + + + + CP +G LEC V +L F LD+
Sbjct: 2361 PGPAG--PKGNRGDSIDQCALIQSIKDKCPCCYG---------PLECPVFPTELAFALDT 2409
Query: 351 SAGTTLDGFLRAKVFVKRFVRAVLSEDSR----ARVGVATYSRELLVAVPVGEYQDVPDL 406
S G D F R + V V + +S ARV V TY+ E+ + + + L
Sbjct: 2410 SEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVL 2469
Query: 407 VWSLDG--IPFRGGPTLTGSALRQAAERGFGSATRTG----------QDRPRRVVVLLTE 454
+ + + +A+ A F R G + P R L E
Sbjct: 2470 LDKIKNLQVALTSKQQSLETAMSFVARNTF-KRVRNGFLMRKVAVFFSNTPTRASPQLRE 2528
Query: 455 SHSEDEVAG--PARHARARELLLLG--------VGSEAVRAELEEITGSPKHVMVYSDPQ 504
+ + AG P R + L+ VG V ++T ++V+
Sbjct: 2529 AVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCL 2588
Query: 505 DLFNQIPELQGKLCSRQRPGCRTQA-------LDLVFMLDTSASVGPENFAQMQSFVRSC 557
D+ N P RP R + +D+ F+LD++ + F +M+ ++
Sbjct: 2589 DICNIDPSCG---FGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYL 2645
Query: 558 ALQFEVNPD------VTQVGLVVYGSQ----------VQTAFGLDTKPTRAAMLRAISQA 601
Q +++PD +V +V + V+ F L ++ ++ +S+
Sbjct: 2646 VRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRG 2705
Query: 602 -PYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKL----R 656
L G + G+A+ + + V + P K VV++ G E AQ++ +
Sbjct: 2706 MTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAK 2763
Query: 657 NNGISVLVVGVG 668
G +V+G+G
Sbjct: 2764 CKGYFFVVLGIG 2775
Score = 33.5 bits (75), Expect = 0.71
Identities = 17/78 (21%), Positives = 36/78 (46%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEY 400
+ D++FLLD S D F FV V V + +VG+ Y+ + + ++
Sbjct: 1637 KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDF 1696
Query: 401 QDVPDLVWSLDGIPFRGG 418
++ +++ + ++GG
Sbjct: 1697 STKRQIIDAINKVVYKGG 1714
Score = 32.0 bits (71), Expect = 2.1
Identities = 43/179 (24%), Positives = 71/179 (39%), Gaps = 26/179 (14%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAV-LSEDSR-----ARVGVATYSRE----- 390
+D+ F+LDS+ TTL F K ++ VR + +S D + ARV V ++
Sbjct: 2618 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2677
Query: 391 -----LLVAVPVGEYQDVPDLVWSLD-GIPFRGGPTLTGSALRQAAERGFGSATRTGQDR 444
+ V + +Y LV L G+ G GSA+ E F SA R
Sbjct: 2678 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAP---NPR 2734
Query: 445 PRRVVVLLTESHSEDEVAGPARH------ARARELLLLGVGSEAVRAELEEITGSPKHV 497
++VVL+ ++ A+ + ++LG+G + E+ P V
Sbjct: 2735 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDV 2793
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 130 bits (326), Expect = 6e-30
Identities = 109/385 (28%), Positives = 178/385 (46%), Gaps = 26/385 (6%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+DSS G DGF + FV R VR + S+ RVGV +S ++ + Y+
Sbjct: 829 DIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRS 888
Query: 403 VPDLVWSLDGIPFRGG-PTLTGSALRQAAERGF-GSATRTGQDRPRRVVVLLTESHSEDE 460
++ ++ + RGG P TG AL A F SA +D + +VL+ S+D+
Sbjct: 889 QAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDD 948
Query: 461 VAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCS 519
V+ A+ R+ ++ LGVG + R EL+ IT P+ V + F ++P ++ ++ +
Sbjct: 949 VSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVRE----FRELPNIEERIMN 1004
Query: 520 RQRPGCRTQA----------------LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563
P T A D+VF+LD S + ++F ++ FV
Sbjct: 1005 SFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYE 1064
Query: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVM 622
+ D QVGLV Y S F L T+ ++ AI++ Y GG + L H+
Sbjct: 1065 DGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHF 1124
Query: 623 TVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG 680
+ G+R VP+ V+TGG+ EDA + L G+ V VGV + SE + ++A
Sbjct: 1125 VPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIAS 1184
Query: 681 PRDSLIHVAAYADLRYHQDVLIEWL 705
+ V +L + ++E L
Sbjct: 1185 NSATAFRVGNVQELSELSEQVLETL 1209
Score = 100 bits (250), Expect = 4e-21
Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E + D+LFL D SA + F + F+ + + + + R+ VA YS ++ V
Sbjct: 226 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 284
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456
E+Q P+++ + + + G L G AL A F SA +D + +VLL
Sbjct: 285 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 344
Query: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V GPA + + ++ + A AELE+I SP ++ + + P++
Sbjct: 345 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 404
Query: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573
L S P + D+VF+LD S V F ++ FV+ +V D +V +V
Sbjct: 405 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 463
Query: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630
Y + + F L++ + ++ A+ Q LGG + G AL + ++ G+R
Sbjct: 464 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 523
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690
GVP+ ++VLT R +D P+ ++ G + +G+G ++ ++ D + +
Sbjct: 524 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 583
Query: 691 YADLRYHQDVLIE 703
+ L Q V+ E
Sbjct: 584 FRQLGTVQQVISE 596
Score = 99.0 bits (245), Expect = 1e-20
Identities = 91/350 (26%), Positives = 161/350 (46%), Gaps = 34/350 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S + F + ++R V + RV V +S + V + +
Sbjct: 626 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 684
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
++ ++ + +GG + G+AL R +R GS G + +VL++ S
Sbjct: 685 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 741
Query: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517
+DEV PA + + + A + EL +I+ SP++V S F ++P L+ KL
Sbjct: 742 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVST----FRELPSLEQKL 797
Query: 518 CSR------------------QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCAL 559
+ P + A D+VF++D+S V P+ FA ++ FV
Sbjct: 798 LTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVR 857
Query: 560 QFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIY 618
+ + P +VG+V + + V F L T ++A +L AI + GG + G AL +
Sbjct: 858 RLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVA 917
Query: 619 DKVMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666
+ G+R GVP+ +V++ GG+ +D + AQ +R++GI L VG
Sbjct: 918 RNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVG 967
Score = 90.9 bits (224), Expect = 4e-18
Identities = 79/253 (31%), Positives = 125/253 (49%), Gaps = 18/253 (7%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS + + SF+ F + D + + ++VG Q++S P EF L FST
Sbjct: 1032 DIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFST 1091
Query: 111 QQEVKARIKRMVFKGGR-TETELALKYL-LHRGLP--GGR-NASVPQILIIVTDGKSQGD 165
++++ I ++V+KGGR T++ L++L ++ +P G R + VPQI ++T GKS D
Sbjct: 1092 KRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVED 1151
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALAS-EPRGQHVLLAEQVEDATNGLFSTLSS 224
S L +RGV VFAVGVR EE+ +AS V +++ + + + TL
Sbjct: 1152 AQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETL-H 1210
Query: 225 SAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFL 284
A+ + P A C L+++ F G+ R V A F S L
Sbjct: 1211 DAMHETLCPGVTDAAKAC---NLDVILGFDGS--------RDQNVFVAQKGFESKVDAIL 1259
Query: 285 THPATCYRTTCPG 297
+ +R +C G
Sbjct: 1260 NRISQMHRVSCSG 1272
Score = 87.0 bits (214), Expect = 5e-17
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S G GF K FV+R V ++ R RV V YS + Y +
Sbjct: 422 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 480
Query: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
D+V ++ + GGPT TG+A LR GS G +++++LT S
Sbjct: 481 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 537
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501
D+V P+ + + +G+G A E++ I+ G+ + V+
Sbjct: 538 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 597
Query: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
Q ++ LQ L PG + D+VF++D S S GPE F +++ +
Sbjct: 598 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 655
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620
+V D T+V ++ + + F L+ ++ + A+ + GG + G AL ++
Sbjct: 656 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 715
Query: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665
+ G+R GVP+ +V+++ G+ ++ PA +L+ G++ +
Sbjct: 716 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 762
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLDGS V G F K F V + LD+ +RVRV Q+S EF L+
Sbjct: 418 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 476
Query: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161
S+ +Q+V ++++ GG T T AL+++L L G R VPQ+LI++T +
Sbjct: 477 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 536
Query: 162 SQGDVALPSKQLKERGVTVFAVGV 185
S DV PS +K G +G+
Sbjct: 537 SGDDVRNPSVVVKRGGAVPIGIGI 560
Score = 78.6 bits (192), Expect = 2e-14
Identities = 41/139 (29%), Positives = 76/139 (54%), Gaps = 3/139 (2%)
Query: 531 DLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPT 590
D+VF++D S+++G NF ++ F+ + E+ D+ QV + Y V+ F +T PT
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 591 RAAMLRAI-SQAPYLGGVGSAGTALLHIYDKVMTVQRG--ARPGVPKAVVVLTGGRGAED 647
+ ++ A+ P G G+AL + + + T G A G+PK +V++TGG+ ++
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
Query: 648 AAVPAQKLRNNGISVLVVG 666
+ PAQ+L+ + I +G
Sbjct: 158 ISQPAQELKRSSIMAFAIG 176
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S G F+ + + D LD+ + RV QFS P +EF L++ S+
Sbjct: 626 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 684
Query: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ EV+ ++R+ KGGR E + + R L VPQ L++++ GKS +
Sbjct: 685 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 744
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
V P+ +LK+ GV F + R EEL ++ P
Sbjct: 745 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 778
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/160 (34%), Positives = 82/160 (51%), Gaps = 5/160 (3%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S A DI+FL+D S V F + F + L+I P +VRVG QFS+ EF L
Sbjct: 825 SDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLK 884
Query: 107 SFSTQQEVKARIKRMVFKGGR-TETELALKYL---LHRGLPGGR-NASVPQILIIVTDGK 161
++ +Q V I+R+ +GG T AL+++ L G R VPQ L++V GK
Sbjct: 885 TYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGK 944
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPR 201
SQ DV+ ++ ++ G+ VG R EL + ++PR
Sbjct: 945 SQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPR 984
Score = 76.6 bits (187), Expect = 7e-14
Identities = 79/332 (23%), Positives = 150/332 (45%), Gaps = 22/332 (6%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S+ L F + F+ + ++ + +V VA Y+ + +
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459
+++ ++ + P G TGSAL F S+ R + P+ ++VL+T S D
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 156
Query: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLC 518
E++ PA+ + ++ +G++ A +AELEEI V + ++ F P LQG L
Sbjct: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAE----FRAAP-LQGMLP 211
Query: 519 SRQRPGCRT-------QALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVG 571
P RT D++F+ D SA++ + F ++ F+ + V P+ T++
Sbjct: 212 GLLAP-LRTLSGTPEESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIA 269
Query: 572 LVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGAR- 629
+ Y V+ D ++ +L + + G + G AL + + G+R
Sbjct: 270 VAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRI 329
Query: 630 -PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
GV + +V+L GR ++ PA L+ +G+
Sbjct: 330 EDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 361
Score = 74.3 bits (181), Expect = 4e-13
Identities = 45/152 (29%), Positives = 83/152 (54%), Gaps = 5/152 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL+DGS+++G +F + F V L+I + ++V Q++ T EF ++ T
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 111 QQEVKARIKRM-VFKGGRTETELALKYL---LHRGLPGGRNA-SVPQILIIVTDGKSQGD 165
++EV +++M G T AL ++ L G R A +P++L+++T GKS +
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALA 197
++ P+++LK + FA+G + EL +A
Sbjct: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL DGS ++ G F + F + D L++ PE R+ Q+S +E D +
Sbjct: 230 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 288
Query: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ E+ +KRM K G+ + A +Y+ + V Q L+++ G+S
Sbjct: 289 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 348
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211
V P+ LK+ GV F + EL + P +L AE +
Sbjct: 349 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 392
Score = 35.0 bits (79), Expect = 0.25
Identities = 90/432 (20%), Positives = 159/432 (36%), Gaps = 76/432 (17%)
Query: 296 PGPCDSQPCQNGGTCVPEG--LDGYQCLCPLAFGGEANCALKLSLECRV---DLLFLLDS 350
PGP P N G + + + + CP +G LEC V +L F LD+
Sbjct: 1754 PGPAG--PKGNRGDSIDQCALIQSIKDKCPCCYG---------PLECPVFPTELAFALDT 1802
Query: 351 SAGTTLDGFLRAKVFVKRFVRAVLSEDSR----ARVGVATYSRELLVAVPVGEYQDVPDL 406
S G D F R + V V + +S ARV V TY+ E+ + + + L
Sbjct: 1803 SEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVL 1862
Query: 407 VWSLDG--IPFRGGPTLTGSALRQAAERGFGSATRTG----------QDRPRRVVVLLTE 454
+ + + +A+ A F R G + P R L E
Sbjct: 1863 LDKIKNLQVALTSKQQSLETAMSFVARNTF-KRVRNGFLMRKVAVFFSNTPTRASPQLRE 1921
Query: 455 SHSEDEVAG--PARHARARELLLLG--------VGSEAVRAELEEITGSPKHVMVYSDPQ 504
+ + AG P R + L+ VG V ++T ++V+
Sbjct: 1922 AVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCL 1981
Query: 505 DLFNQIPELQGKLCSRQRPGCRTQA-------LDLVFMLDTSASVGPENFAQMQSFVRSC 557
D+ N P RP R + +D+ F+LD++ + F +M+ ++
Sbjct: 1982 DICNIDPSCG---FGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYL 2038
Query: 558 ALQFEVNPD------VTQVGLVVYGSQ----------VQTAFGLDTKPTRAAMLRAISQA 601
Q +++PD +V +V + V+ F L ++ ++ +S+
Sbjct: 2039 VRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRG 2098
Query: 602 -PYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKL----R 656
L G + G+A+ + + V + P K VV++ G E AQ++ +
Sbjct: 2099 MTQLQGTRALGSAIEYTIENVF--ESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAK 2156
Query: 657 NNGISVLVVGVG 668
G +V+G+G
Sbjct: 2157 CKGYFFVVLGIG 2168
Score = 33.5 bits (75), Expect = 0.71
Identities = 17/78 (21%), Positives = 36/78 (46%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEY 400
+ D++FLLD S D F FV V V + +VG+ Y+ + + ++
Sbjct: 1030 KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDF 1089
Query: 401 QDVPDLVWSLDGIPFRGG 418
++ +++ + ++GG
Sbjct: 1090 STKRQIIDAINKVVYKGG 1107
Score = 32.0 bits (71), Expect = 2.1
Identities = 43/179 (24%), Positives = 71/179 (39%), Gaps = 26/179 (14%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAV-LSEDSR-----ARVGVATYSRE----- 390
+D+ F+LDS+ TTL F K ++ VR + +S D + ARV V ++
Sbjct: 2011 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2070
Query: 391 -----LLVAVPVGEYQDVPDLVWSLD-GIPFRGGPTLTGSALRQAAERGFGSATRTGQDR 444
+ V + +Y LV L G+ G GSA+ E F SA R
Sbjct: 2071 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVFESAP---NPR 2127
Query: 445 PRRVVVLLTESHSEDEVAGPARH------ARARELLLLGVGSEAVRAELEEITGSPKHV 497
++VVL+ ++ A+ + ++LG+G + E+ P V
Sbjct: 2128 DLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDV 2186
>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
Length = 1796
Score = 124 bits (311), Expect = 3e-28
Identities = 64/160 (40%), Positives = 95/160 (59%), Gaps = 2/160 (1%)
Query: 48 AAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDS 107
A DI+ L+DGS S+G+ +F +HF + D+ E+ R+G Q+S P +E+ L++
Sbjct: 155 AIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNA 214
Query: 108 FSTQQEVKARIKRMVFKGGRTETELALKYLLHRGL--PGGRNASVPQILIIVTDGKSQGD 165
FST+ EV ++ + +KGG T T LAL Y+ G V +I I++TDGKSQ D
Sbjct: 215 FSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDD 274
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHV 205
+ PS+ L+E GV +FA+GV+ EL +ASEP HV
Sbjct: 275 IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHV 314
Score = 103 bits (256), Expect = 7e-22
Identities = 60/196 (30%), Positives = 109/196 (55%), Gaps = 6/196 (3%)
Query: 46 CSAA-VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLD-ISPERVRVGAFQFSSTPHLEF 103
C AA D++F++DGS S+G +F + F + L+ I + +V QF+ P EF
Sbjct: 1026 CKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEF 1085
Query: 104 PLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHR--GLPGGRNASVPQILIIVTDGK 161
L+++ T++ + IK + +KGG T+T A+KY+ G +P++++++TDG+
Sbjct: 1086 KLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGR 1145
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFST 221
SQ DV S++++ G ++FA+GV + EL ++ S+P +HV + DA +
Sbjct: 1146 SQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDF-DAFKKIEDE 1204
Query: 222 LSSSAICSSATPDCRV 237
L + +C +A+ C V
Sbjct: 1205 L-ITFVCETASATCPV 1219
Score = 96.7 bits (239), Expect = 7e-20
Identities = 69/229 (30%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 482 AVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSAS 541
+V +L+EI G +M Q L + P + + C+ DLVFM+D S S
Sbjct: 986 SVYTKLQEIEGPSVSIM--EKTQSLPTRPPTFPPTIPPAKEV-CKAAKADLVFMVDGSWS 1042
Query: 542 VGPENFAQMQSFVRSCALQF-EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQ 600
+G ENF ++ SF+ S ++ D TQV +V + +T F L+ T+ +L AI
Sbjct: 1043 IGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKH 1102
Query: 601 APYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
Y GG G A+ ++ D + T + G R G+PK +VV+T GR +D +++++ +G
Sbjct: 1103 ISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRSQDDVNKISREMQLDGY 1162
Query: 661 SVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYAD---LRYHQDVLIEWLC 706
S+ +GV L + G + S HV D + +D LI ++C
Sbjct: 1163 SIFAIGVADADYSELVSI-GSKPSARHVFFVDDFDAFKKIEDELITFVC 1210
Score = 89.4 bits (220), Expect = 1e-17
Identities = 52/185 (28%), Positives = 96/185 (51%), Gaps = 3/185 (1%)
Query: 525 CRTQAL-DLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAF 583
C+T A+ D+V ++D S S+G NF ++ F+ + F+V + T++GL Y + +
Sbjct: 151 CQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEW 210
Query: 584 GLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGR 643
L+ T+ ++ A+ PY GG G AL +I++ + G+R GV K +++T G+
Sbjct: 211 HLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGK 270
Query: 644 GAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDS--LIHVAAYADLRYHQDVL 701
+D P++ LR +G+ + +GV L+ +A DS + +VA + + + L
Sbjct: 271 SQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESL 330
Query: 702 IEWLC 706
LC
Sbjct: 331 TRTLC 335
Score = 73.2 bits (178), Expect = 8e-13
Identities = 54/184 (29%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++ L+D S F + F++ V A + R+G+A YS + + + +
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGF--GSATRTGQDRPRRVVVLLTESHSEDE 460
+++ ++ +P++GG TLTG AL E F + +RTG ++ +L+T+ S+D+
Sbjct: 218 KDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVS---KIGILITDGKSQDD 274
Query: 461 VAGPARHARAR--ELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQ-DLFNQIPE-LQGK 516
+ P+R+ R EL +GV + V EL+EI P VY+ + DL + + E L
Sbjct: 275 IIPPSRNLRESGVELFAIGVKNADVN-ELQEIASEPDSTHVYNVAEFDLMHTVVESLTRT 333
Query: 517 LCSR 520
LCSR
Sbjct: 334 LCSR 337
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/177 (23%), Positives = 87/177 (49%), Gaps = 8/177 (4%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAV--LSEDSRARVGVATYSRELLVAVPVG 398
+ DL+F++D S + F + F+ V A+ + D +V + ++ + +
Sbjct: 1030 KADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDG-TQVAMVQFTDDPRTEFKLN 1088
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458
Y+ L+ ++ I ++GG T TG A++ + F + + T + P +V+V++T+ S+
Sbjct: 1089 AYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIP-KVIVVITDGRSQ 1147
Query: 459 DEVAGPARHARARELLLLGVG-SEAVRAELEEITGSP--KHVMVYSDPQDLFNQIPE 512
D+V +R + + +G ++A +EL I P +HV + D D F +I +
Sbjct: 1148 DDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVF-FVDDFDAFKKIED 1203
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 119 bits (298), Expect = 1e-26
Identities = 63/165 (38%), Positives = 99/165 (60%), Gaps = 5/165 (3%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++DGS S+G+ +FE K F + D L ISP+ RVG Q+S+ H EF L +F+
Sbjct: 654 IDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFN 713
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
+ +++K + M + G + T LALK++ R G A VP+ I+ TDG++Q
Sbjct: 714 SAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAE 209
DV+ + + K G+T++AVGV EEL +ASEP +H+ AE
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAE 818
Score = 111 bits (277), Expect = 3e-24
Identities = 66/200 (33%), Positives = 106/200 (53%), Gaps = 11/200 (5%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++F++D S SV + + K F + + LDI P+ RVG Q+ ST EF L +F
Sbjct: 57 DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQGD 165
+ EV+ +KRM T T LA++Y L+ A +VP++++IVTDG+ Q
Sbjct: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLA---EQVEDATNGLFSTL 222
VA + + ++ G+ +FA+GV + L ++ SEP HV L Q+E T+ L
Sbjct: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
Query: 223 SSSAICSSATPDCRVEAHPC 242
++ +CS+ +C AH C
Sbjct: 237 CTAHMCSTLEHNC---AHFC 253
Score = 105 bits (262), Expect = 1e-22
Identities = 59/168 (35%), Positives = 91/168 (54%), Gaps = 7/168 (4%)
Query: 515 GKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVV 574
G+ C + C +DLVF++D S S+G ENF ++ FV ++P +VGL+
Sbjct: 643 GRRCKK----CTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQ 698
Query: 575 YGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---G 631
Y +QV T F L + M +A++ Y+G G AL H++++ T GARP
Sbjct: 699 YSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTR 758
Query: 632 VPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
VP+A +V T GR +D + A K + NGI++ VGVG + E L+ +A
Sbjct: 759 VPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806
Score = 97.8 bits (242), Expect = 3e-20
Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 5/201 (2%)
Query: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
C + DLVF++D+S SV ++A+++ F+ ++ PDVT+VGL+ YGS V+ F
Sbjct: 51 CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
Query: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVLTG 641
L T ++ + RA+ + +L G A+ + + + GARP VP+ ++++T
Sbjct: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
Query: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP--RDSLIHVAAYADLRYHQD 699
GR + A A K R+ GI + +GVG V L+ + D + VA ++ +
Sbjct: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
Query: 700 VLIEWLCGGEWGNPHPQGCPH 720
V + LC + C H
Sbjct: 231 VFQKKLCTAHMCSTLEHNCAH 251
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/214 (27%), Positives = 98/214 (45%), Gaps = 11/214 (5%)
Query: 310 CVPEGLDGYQCLCPLAFG-GEANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKR 368
CV G + Y C C F E K E +DL+F++D S + F K FV
Sbjct: 622 CVNNG-NSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTG 680
Query: 369 FVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQ 428
+ ++ ARVG+ YS ++ + + D+ ++ + + G ++TG AL+
Sbjct: 681 IIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKH 740
Query: 429 AAERGF--GSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVG-SEAVRA 485
ER F G R R R ++ T+ ++D+V+ A A+A + + VG +A+
Sbjct: 741 MFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEE 800
Query: 486 ELEEITGSP--KHVMVYSDPQDLFNQIPELQGKL 517
EL+EI P KH+ D F+ + E+ KL
Sbjct: 801 ELQEIASEPTNKHLFYAED----FSTMDEISEKL 830
Score = 50.4 bits (119), Expect = 6e-06
Identities = 44/196 (22%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 329 EANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYS 388
E++C K R DL+F++DSS + + K F+ ++ + RVG+ Y
Sbjct: 48 ESSCENK-----RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
Query: 389 RELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSA--TRTGQDRPR 446
+ + ++ ++ ++ + T+TG A++ A F A R ++
Sbjct: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
Query: 447 RVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEITGS---PKHVMVYSDP 503
RV++++T+ +D VA A AR +L+ +G V + GS HV + ++
Sbjct: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
Query: 504 QDLFNQIPELQGKLCS 519
+ Q KLC+
Sbjct: 223 SQIETLTSVFQKKLCT 238
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 119 bits (298), Expect = 1e-26
Identities = 63/165 (38%), Positives = 99/165 (60%), Gaps = 5/165 (3%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
+D++F++DGS S+G+ +FE K F + D L ISP+ RVG Q+S+ H EF L +F+
Sbjct: 654 IDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFN 713
Query: 110 TQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQG 164
+ +++K + M + G + T LALK++ R G A VP+ I+ TDG++Q
Sbjct: 714 SAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAE 209
DV+ + + K G+T++AVGV EEL +ASEP +H+ AE
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAE 818
Score = 111 bits (277), Expect = 3e-24
Identities = 66/200 (33%), Positives = 106/200 (53%), Gaps = 11/200 (5%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++F++D S SV + + K F + + LDI P+ RVG Q+ ST EF L +F
Sbjct: 57 DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNA-----SVPQILIIVTDGKSQGD 165
+ EV+ +KRM T T LA++Y L+ A +VP++++IVTDG+ Q
Sbjct: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLA---EQVEDATNGLFSTL 222
VA + + ++ G+ +FA+GV + L ++ SEP HV L Q+E T+ L
Sbjct: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
Query: 223 SSSAICSSATPDCRVEAHPC 242
++ +CS+ +C AH C
Sbjct: 237 CTAHMCSTLEHNC---AHFC 253
Score = 105 bits (262), Expect = 1e-22
Identities = 59/168 (35%), Positives = 91/168 (54%), Gaps = 7/168 (4%)
Query: 515 GKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVV 574
G+ C + C +DLVF++D S S+G ENF ++ FV ++P +VGL+
Sbjct: 643 GRRCKK----CTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQ 698
Query: 575 YGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---G 631
Y +QV T F L + M +A++ Y+G G AL H++++ T GARP
Sbjct: 699 YSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTR 758
Query: 632 VPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
VP+A +V T GR +D + A K + NGI++ VGVG + E L+ +A
Sbjct: 759 VPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806
Score = 97.8 bits (242), Expect = 3e-20
Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 5/201 (2%)
Query: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
C + DLVF++D+S SV ++A+++ F+ ++ PDVT+VGL+ YGS V+ F
Sbjct: 51 CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
Query: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPKAVVVLTG 641
L T ++ + RA+ + +L G A+ + + + GARP VP+ ++++T
Sbjct: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
Query: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGP--RDSLIHVAAYADLRYHQD 699
GR + A A K R+ GI + +GVG V L+ + D + VA ++ +
Sbjct: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
Query: 700 VLIEWLCGGEWGNPHPQGCPH 720
V + LC + C H
Sbjct: 231 VFQKKLCTAHMCSTLEHNCAH 251
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/214 (27%), Positives = 98/214 (45%), Gaps = 11/214 (5%)
Query: 310 CVPEGLDGYQCLCPLAFG-GEANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKR 368
CV G + Y C C F E K E +DL+F++D S + F K FV
Sbjct: 622 CVNNG-NSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTG 680
Query: 369 FVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQ 428
+ ++ ARVG+ YS ++ + + D+ ++ + + G ++TG AL+
Sbjct: 681 IIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKH 740
Query: 429 AAERGF--GSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVG-SEAVRA 485
ER F G R R R ++ T+ ++D+V+ A A+A + + VG +A+
Sbjct: 741 MFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEE 800
Query: 486 ELEEITGSP--KHVMVYSDPQDLFNQIPELQGKL 517
EL+EI P KH+ D F+ + E+ KL
Sbjct: 801 ELQEIASEPTNKHLFYAED----FSTMDEISEKL 830
Score = 50.4 bits (119), Expect = 6e-06
Identities = 44/196 (22%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 329 EANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYS 388
E++C K R DL+F++DSS + + K F+ ++ + RVG+ Y
Sbjct: 48 ESSCENK-----RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
Query: 389 RELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSA--TRTGQDRPR 446
+ + ++ ++ ++ + T+TG A++ A F A R ++
Sbjct: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
Query: 447 RVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEITGS---PKHVMVYSDP 503
RV++++T+ +D VA A AR +L+ +G V + GS HV + ++
Sbjct: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
Query: 504 QDLFNQIPELQGKLCS 519
+ Q KLC+
Sbjct: 223 SQIETLTSVFQKKLCT 238
>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
Length = 1284
Score = 117 bits (294), Expect = 3e-26
Identities = 70/180 (38%), Positives = 107/180 (59%), Gaps = 4/180 (2%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S+G F++ K F +V +I P++V+VG Q+S E+ L+S ST
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHRGL--PGGRNASVPQILIIVTDGKSQGDVAL 168
+++V A ++R+ +KGG T T LAL ++L + L G +++I+VTDGKSQ DV
Sbjct: 239 KEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHT 298
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAIC 228
++ LK+ GV VFAVGV+ EL LAS PR + + ++ G + L S IC
Sbjct: 299 AARVLKDLGVNVFAVGVKNADEAELRLLASPPR--DITVHSVLDFLQLGALAGLLSRLIC 356
Score = 102 bits (254), Expect = 1e-21
Identities = 63/189 (33%), Positives = 96/189 (50%), Gaps = 2/189 (1%)
Query: 531 DLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPT 590
D+VF++D S S+G +F Q++ F+ S FE+ PD QVGL Y QT + L++ T
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238
Query: 591 RAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAV 650
+ +L A+ + Y GG G AL H+ + + G RP K V+++T G+ +D
Sbjct: 239 KEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHT 298
Query: 651 PAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PRDSLIH-VAAYADLRYHQDVLIEWLCGG 708
A+ L++ G++V VGV LR LA PRD +H V + L +L +C
Sbjct: 299 AARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLICQR 358
Query: 709 EWGNPHPQG 717
G QG
Sbjct: 359 LQGGSPRQG 367
Score = 52.4 bits (124), Expect = 1e-06
Identities = 54/206 (26%), Positives = 86/206 (41%), Gaps = 18/206 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S F + K F+ + + +VG+ YS + +
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVA 462
++ ++ + ++GG T TG AL + A + +VV+L+T+ S+D+V
Sbjct: 239 KEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGL-RPEAAKVVILVTDGKSQDDV- 296
Query: 463 GPARHARARELLLLGVGSEAV------RAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
H AR L LGV AV AEL + P+ + V+S F Q+ L G
Sbjct: 297 ----HTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLD--FLQLGALAGL 350
Query: 517 L----CSRQRPGCRTQALDLVFMLDT 538
L C R + G Q LDT
Sbjct: 351 LSRLICQRLQGGSPRQGPAAAPALDT 376
>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
Length = 1626
Score = 116 bits (291), Expect = 6e-26
Identities = 72/206 (34%), Positives = 107/206 (51%), Gaps = 12/206 (5%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLD S+SVGK FE+ + + + D ++ P+R RVG ++S P F L
Sbjct: 34 SVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELG 93
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGL---PGG--RNASVPQILIIVTDGK 161
F +Q+EVKA +R+ + GG T T AL+Y+ R GG R+ + Q+ I++TDG+
Sbjct: 94 LFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGR 153
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQ---VEDATNGL 218
SQ V + G+ +FAVGV EEL +ASEP+ HV ++ L
Sbjct: 154 SQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNAIDKIRGKL 213
Query: 219 FSTLSSSAICSSATPDCRVEAHPCEH 244
L + +C P RVE +H
Sbjct: 214 RRRLCENVLC----PSVRVEGDRFKH 235
Score = 99.0 bits (245), Expect = 1e-20
Identities = 62/179 (34%), Positives = 92/179 (51%), Gaps = 5/179 (2%)
Query: 518 CSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGS 577
C QR GC++ DLVF+LDTS+SVG E+F +++ +V + FEV PD T+VG+V Y
Sbjct: 25 CQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSD 84
Query: 578 QVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP---GVPK 634
+ TAF L ++ + A + Y GG + G AL +I + + G RP +
Sbjct: 85 RPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQ 144
Query: 635 AVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDS--LIHVAAY 691
++LT GR + A GI + VGVG L E L +A S + HV+ +
Sbjct: 145 VAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDF 203
Score = 83.6 bits (205), Expect = 6e-16
Identities = 66/185 (35%), Positives = 92/185 (49%), Gaps = 13/185 (7%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
DL+FLLD+S+ + F + + +V V R RVGV YS A +G +
Sbjct: 38 DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPR---RVVVLLTESHSED 459
++ + + + GG T TG ALR R F S G+ R R +V +LLT+ S+D
Sbjct: 98 QEEVKAAARRLAYHGGNTNTGDALRYITARSF-SPHAGGRPRDRAYKQVAILLTDGRSQD 156
Query: 460 EV--AGPARHARARELLLLGVGSEAVRAELEEITGSPK--HVMVYSDPQDLFNQIPELQG 515
V A A H + +GVG EA++ ELEEI PK HV SD FN I +++G
Sbjct: 157 LVLDAAAAAHRAGIRIFAVGVG-EALKEELEEIASEPKSAHVFHVSD----FNAIDKIRG 211
Query: 516 KLCSR 520
KL R
Sbjct: 212 KLRRR 216
>gi|93141047 collagen, type XII, alpha 1 long isoform precursor
[Homo sapiens]
Length = 3063
Score = 115 bits (289), Expect = 1e-25
Identities = 66/183 (36%), Positives = 103/183 (56%), Gaps = 5/183 (2%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
SA D++FL+DGS SVG+ +F+ F + DI E+ RVG Q+SS EF L+
Sbjct: 136 SAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLN 195
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGL--PGGRNASVPQILIIVTDGKSQG 164
+ + E+ A IK++ +KGG T T A+ YL+ G P++ II+TDGKSQ
Sbjct: 196 QYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFPKVAIIITDGKSQD 255
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLA---EQVEDATNGLFST 221
+V +P+++L+ GV VF++G++ +EL +AS P HV + + D N + S
Sbjct: 256 EVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQ 315
Query: 222 LSS 224
+ S
Sbjct: 316 VCS 318
Score = 106 bits (265), Expect = 7e-23
Identities = 61/173 (35%), Positives = 96/173 (55%), Gaps = 6/173 (3%)
Query: 46 CSAAVDI----MFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHL 101
CS VDI +FL+DGS S+G +F + + F + +ISP RV++ Q+S PH
Sbjct: 431 CSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHT 490
Query: 102 EFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHR-GLPG-GRNASVPQILIIVTD 159
EF L F+ +++ I ++GG T T A+ Y+ + +P G ++VP+++I++TD
Sbjct: 491 EFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITD 550
Query: 160 GKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVE 212
GKS P+ +L+ V +FAVGV+ EL A+AS P HV E +
Sbjct: 551 GKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFD 603
Score = 106 bits (264), Expect = 9e-23
Identities = 74/260 (28%), Positives = 123/260 (47%), Gaps = 16/260 (6%)
Query: 464 PARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRP 523
P +E L +E + +EL T + Y + ++ I +L + S +P
Sbjct: 61 PTTDGPTKEFTLSASTTETLLSELVPETEYVVTITSYDEVEESVPVIGQLTIQTGSSTKP 120
Query: 524 -----------GCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVG 571
C A DLVF++D S SVG NF + F+ + F++ + T+VG
Sbjct: 121 VEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVG 180
Query: 572 LVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPG 631
+V Y S +T F L+ R +L AI + PY GG G A+ ++ T GAR G
Sbjct: 181 VVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVG 240
Query: 632 VPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAY 691
PK +++T G+ ++ +PA++LRN G+ V +G+ ++ L+++A SL HV
Sbjct: 241 FPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIAS-TPSLNHVFNV 299
Query: 692 ADLRYHQDV---LIEWLCGG 708
A+ D+ +I +C G
Sbjct: 300 ANFDAIVDIQNEIISQVCSG 319
Score = 105 bits (263), Expect = 1e-22
Identities = 61/203 (30%), Positives = 108/203 (53%), Gaps = 9/203 (4%)
Query: 29 VSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERV 88
+S T+ I ++ A DI+ L+DGS S+G+ +F + F + + DI P+RV
Sbjct: 1177 LSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRV 1236
Query: 89 RVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGL--PGGR 146
++ Q+S P E+ L++ ++ + + + +KGG T T +AL ++ + G
Sbjct: 1237 QIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGM 1296
Query: 147 NASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVL 206
+I +++TDGKSQ DV PSK+LK+ GV +FA+G++ EL +A++P H
Sbjct: 1297 RPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAY 1356
Query: 207 -------LAEQVEDATNGLFSTL 222
L+ V+D T L +++
Sbjct: 1357 NVADFESLSRIVDDLTINLCNSV 1379
Score = 101 bits (251), Expect = 3e-21
Identities = 69/244 (28%), Positives = 122/244 (50%), Gaps = 7/244 (2%)
Query: 462 AGPARHARARELLLLGVGSEAVRAELE-EITGSPKHVMVYSDPQDLFNQIPELQGKL-CS 519
AG +HA + + + A+ E +I+ S M S+P + + ++ ++ CS
Sbjct: 373 AGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECS 432
Query: 520 RQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQV 579
R G +A D+VF++D S S+G NF ++++F+ FE++P+ Q+ LV Y
Sbjct: 433 R---GVDIKA-DIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDP 488
Query: 580 QTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVL 639
T F L ++ AI+ PY GG + G A+ ++ +K+ +G+R VPK ++++
Sbjct: 489 HTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILI 548
Query: 640 TGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQD 699
T G+ ++ PA KLRN+ + + VGV + L +A P + HV D Q
Sbjct: 549 TDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASP-PAETHVFTVEDFDAFQR 607
Query: 700 VLIE 703
+ E
Sbjct: 608 ISFE 611
Score = 98.2 bits (243), Expect = 2e-20
Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 11/194 (5%)
Query: 48 AAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLD-ISPERVRVGAFQFSSTPHLEFPLD 106
A DI+FL D S S+G +F + F G D ISP ++V Q+S EF L+
Sbjct: 2320 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 2379
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLP--GGRNASVPQILIIVTDGKSQG 164
+++ + ++ + ++GG T T AL ++ + L G +VP++L++VTDG+SQ
Sbjct: 2380 TYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQD 2439
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
+V + +++ G +VF VGV + EL +AS+P +HV + + E F +
Sbjct: 2440 EVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFES-----FEKIED 2494
Query: 225 SAI---CSSATPDC 235
+ I C +AT C
Sbjct: 2495 NLITFVCETATSSC 2508
Score = 96.3 bits (238), Expect = 9e-20
Identities = 65/189 (34%), Positives = 97/189 (51%), Gaps = 5/189 (2%)
Query: 522 RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF-EVNPDVTQVGLVVYGSQVQ 580
R C+ D+VF+ D S S+G +NF ++ F+ + F E++P QV V Y +V+
Sbjct: 2314 RDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVK 2373
Query: 581 TAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLT 640
+ F L+T +A L A+ Y GG G AL I +KV+T + G R VPK +VV+T
Sbjct: 2374 SEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVT 2433
Query: 641 GGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYH--- 697
GR ++ A ++ +G SV VVGV V L +A + S HV D
Sbjct: 2434 DGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIAS-KPSERHVFIVDDFESFEKI 2492
Query: 698 QDVLIEWLC 706
+D LI ++C
Sbjct: 2493 EDNLITFVC 2501
Score = 87.4 bits (215), Expect = 4e-17
Identities = 55/190 (28%), Positives = 92/190 (48%), Gaps = 3/190 (1%)
Query: 525 CRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAF 583
C T+A D+V ++D S S+G NF ++SF+ F++ P Q+ L Y +T +
Sbjct: 1192 CLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEW 1251
Query: 584 GLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGR 643
L+ + ++L+A++ PY GG G AL I + Q G RP K V++T G+
Sbjct: 1252 QLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGK 1311
Query: 644 GAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDS--LIHVAAYADLRYHQDVL 701
+D P++KL++ G+ + +G+ L+ +A D +VA + L D L
Sbjct: 1312 SQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 1371
Query: 702 IEWLCGGEWG 711
LC G
Sbjct: 1372 TINLCNSVKG 1381
Score = 84.7 bits (208), Expect = 3e-16
Identities = 54/196 (27%), Positives = 103/196 (52%), Gaps = 10/196 (5%)
Query: 334 LKLSLEC------RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATY 387
+K+ +EC + D++FL+D S + F++ + F++ V++ +R ++ + Y
Sbjct: 425 MKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQY 484
Query: 388 SRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRR 447
SR+ + ++ V D++ +++ P+RGG T TG A+ E+ F + + + P +
Sbjct: 485 SRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVP-K 543
Query: 448 VVVLLTESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYS-DPQD 505
V++L+T+ S D PA R ++ + VG +AVR+ELE I P V++ + D
Sbjct: 544 VMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFD 603
Query: 506 LFNQIP-ELQGKLCSR 520
F +I EL +C R
Sbjct: 604 AFQRISFELTQSICLR 619
Score = 77.0 bits (188), Expect = 6e-14
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 4/200 (2%)
Query: 335 KLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVA 394
K S+ DL+FL+D S + F F+ V A + + RVGV YS +
Sbjct: 132 KCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTE 191
Query: 395 VPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTE 454
+ +Y +L+ ++ IP++GG T+TG A+ + F + P +V +++T+
Sbjct: 192 FNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFP-KVAIIITD 250
Query: 455 SHSEDEVAGPARHARARELLLLGVGSEAVRA-ELEEITGSPKHVMVYSDPQDLFNQIPEL 513
S+DEV PAR R + + +G +A A EL++I +P V++ F+ I ++
Sbjct: 251 GKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVAN--FDAIVDI 308
Query: 514 QGKLCSRQRPGCRTQALDLV 533
Q ++ S+ G Q +LV
Sbjct: 309 QNEIISQVCSGVDEQLGELV 328
Score = 70.1 bits (170), Expect = 7e-12
Identities = 51/194 (26%), Positives = 91/194 (46%), Gaps = 10/194 (5%)
Query: 334 LKLSLEC----RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSR 389
L +EC D++ L+D S F + F+ R V R ++ +A YS
Sbjct: 1186 LSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSG 1245
Query: 390 ELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTG-QDRPRRV 448
+ + ++D L+ ++ +P++GG TLTG AL ++ F T+ G + R R++
Sbjct: 1246 DPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNF--RTQAGMRPRARKI 1303
Query: 449 VVLLTESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVY--SDPQD 505
VL+T+ S+D+V P++ + + L +G A EL+ I P Y +D +
Sbjct: 1304 GVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFES 1363
Query: 506 LFNQIPELQGKLCS 519
L + +L LC+
Sbjct: 1364 LSRIVDDLTINLCN 1377
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/245 (25%), Positives = 102/245 (41%), Gaps = 18/245 (7%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVA--TYSRELLVAVPVG 398
+ D++FL D+S D F + F+ V E S A + V+ YS E+ +
Sbjct: 2321 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGG-FDEISPAGIQVSFVQYSDEVKSEFKLN 2379
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458
Y D + +L I +RGG T TG AL E+ + ++ P +V+V++T+ S+
Sbjct: 2380 TYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVP-KVLVVVTDGRSQ 2438
Query: 459 DEVAGPARHARARELLLLGVG-SEAVRAELEEITGSP--KHVMVYSDPQDLFNQIPELQG 515
DEV A + + VG ++ EL I P +HV + D + L
Sbjct: 2439 DEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLIT 2498
Query: 516 KLCSRQRPGCRTQALDLV----FMLDTSASVGPENFAQMQ-------SFVRSCALQFEVN 564
+C C LD F + + ++ +NFA +Q SF A + + N
Sbjct: 2499 FVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRIQKN 2558
Query: 565 PDVTQ 569
V Q
Sbjct: 2559 AFVNQ 2563
>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
Length = 2813
Score = 114 bits (284), Expect = 4e-25
Identities = 97/352 (27%), Positives = 163/352 (46%), Gaps = 18/352 (5%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQ 401
+D+ F+L+ S F R+K F++ ++ + V V YS + V P E Q
Sbjct: 1497 LDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQ 1556
Query: 402 DVPDLVWSLDGIPFRGGP-TLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDE 460
D++ + I ++GG T TG ALR ++ F ++ +++ +V ++T + + DE
Sbjct: 1557 SKGDILQRVREIRYQGGNRTNTGLALRYLSDHSF-LVSQGDREQAPNLVYMVTGNPASDE 1615
Query: 461 VAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSR 520
+ R +++ +GVG A ELE I G P ++ D + L + P+L + C
Sbjct: 1616 IK---RLPGDIQVVPIGVGPNANVQELERI-GWPNAPILIQDFETLPREAPDLVLQRCCS 1671
Query: 521 QR----------PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQV 570
P C +Q LD++ +LD S+S F +M+SF ++ + + P +TQV
Sbjct: 1672 GEGLQIPTLSPAPDC-SQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQV 1730
Query: 571 GLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP 630
++ YGS + P +A +L + GG G AL + + GARP
Sbjct: 1731 SVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARP 1790
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEG-LRRLAGP 681
G KAVV+L + A R+N ++V +G+G LR LAGP
Sbjct: 1791 GASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGP 1842
Score = 70.9 bits (172), Expect = 4e-12
Identities = 42/153 (27%), Positives = 78/153 (50%), Gaps = 7/153 (4%)
Query: 19 PPSLP--LQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAIT 76
PP+LP + +V V +G + K S +D+ F+L+GS+ +G+ F RSK F
Sbjct: 1466 PPTLPPDMAQVTVGPGLLGVSTLGPKRN--SMVLDVAFVLEGSDKIGEADFNRSKEFMEE 1523
Query: 77 VCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGG-RTETELALK 135
V +D+ + + V Q+S +E+P ++ ++ R++ + ++GG RT T LAL+
Sbjct: 1524 VIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALR 1583
Query: 136 YLLHRG--LPGGRNASVPQILIIVTDGKSQGDV 166
YL + G P ++ +VT + ++
Sbjct: 1584 YLSDHSFLVSQGDREQAPNLVYMVTGNPASDEI 1616
Score = 63.2 bits (152), Expect = 8e-10
Identities = 83/408 (20%), Positives = 154/408 (37%), Gaps = 50/408 (12%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQ 401
+DL+FLLD S+ + F K FV + + RV V Y + + + +
Sbjct: 1276 LDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRK 1335
Query: 402 DVPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR--RVVVLLTESHSE 458
+L + + G T L+ + F DRP R+ +LL S
Sbjct: 1336 RPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKI-----DRPEASRITLLLMASQEP 1390
Query: 459 DEVAGP----ARHARARELLLLGVG----SEAVRAELEEITGSPKHVMVYSDPQDLFNQI 510
++ + + ++++++ VG + + L E V S +L Q
Sbjct: 1391 QRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQR 1450
Query: 511 PELQGKLC---------------------------SRQRPGCRTQALDLVFMLDTSASVG 543
E+ LC S P + LD+ F+L+ S +G
Sbjct: 1451 DEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIG 1510
Query: 544 PENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPY 603
+F + + F+ + +V D V ++ Y V + ++ +L+ + + Y
Sbjct: 1511 EADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRY 1570
Query: 604 LGG-VGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISV 662
GG + G AL ++ D V +G R P V ++TG +++ K I V
Sbjct: 1571 QGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEI-----KRLPGDIQV 1625
Query: 663 LVVGVGPVLS-EGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGGE 709
+ +GVGP + + L R+ P ++ R D++++ C GE
Sbjct: 1626 VPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGE 1673
Score = 57.8 bits (138), Expect = 4e-08
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 15/177 (8%)
Query: 46 CSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPL 105
CS +D++ LLDGS+S F+ K FA +I P +V Q+ S ++ P
Sbjct: 1686 CSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPW 1745
Query: 106 DSFSTQQEVKARIKRMVFKGGRTE----TELALKYL---LHRGLPGGRNASVPQILIIVT 158
+ + + + + M +GG ++ A++YL +H PG A ++I+VT
Sbjct: 1746 NVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKA----VVILVT 1801
Query: 159 DGKSQGDVALPSKQLKERGVTVFAVGVRFPRWE--ELHALASEPRGQHVLLAEQVED 213
D S V + + VTVF +G+ R++ +L LA +V+ +++ED
Sbjct: 1802 D-VSVDSVDAAADAARSNRVTVFPIGIG-DRYDAAQLRILAGPAGDSNVVKLQRIED 1856
Score = 50.1 bits (118), Expect = 7e-06
Identities = 46/203 (22%), Positives = 84/203 (41%), Gaps = 16/203 (7%)
Query: 511 PELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQV 570
P L CSR LDLVF+LD S+ + F +++FV + ++ +V
Sbjct: 1265 PPLHDFYCSR--------LLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRV 1316
Query: 571 GLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP 630
+V Y GL + + + R SQ Y G ++ + +L Y + RP
Sbjct: 1317 AVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLK-YTLFQIFSKIDRP 1375
Query: 631 GVPKAVVVLTGG----RGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRL---AGPRD 683
+ ++L R + + Q L+ + V+ VG+GP + RL P +
Sbjct: 1376 EASRITLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPEN 1435
Query: 684 SLIHVAAYADLRYHQDVLIEWLC 706
+++ +L +D ++ +LC
Sbjct: 1436 KAFVLSSVDELEQQRDEIVSYLC 1458
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Query: 45 WCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFP 104
+CS +D++FLLDGS+ + + FE K F + + + L IS + VRV ++ H
Sbjct: 1271 YCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIG 1330
Query: 105 LDSFSTQQEVKARIKRMVFKGGR-TETELALKYLL 138
L E++ ++ + G + T LKY L
Sbjct: 1331 LKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTL 1365
>gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
sapiens]
Length = 1036
Score = 110 bits (274), Expect = 6e-24
Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S+ L F + F+ + ++ + +V VA Y+ + +
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459
+++ ++ + P G TGSAL F S+ R + P+ ++VL+T S D
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 156
Query: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516
E++ PA+ + ++ +G++ A +AELEEI V + ++ L +P L
Sbjct: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 216
Query: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
L + P + D++F+LD SA+VG NF ++ FV + ++ D +VGLV +
Sbjct: 217 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 276
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632
T F L+T T++ +L + Q GG G + G+AL ++Y T G+ R V
Sbjct: 277 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 336
Query: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
P+ +++LT G+ + A L GI VG L ++A
Sbjct: 337 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
Score = 100 bits (250), Expect = 4e-21
Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E + D+LFL D SA + F + F+ + + + + R+ VA YS ++ V
Sbjct: 426 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456
E+Q P+++ + + + G L G AL A F SA +D + +VLL
Sbjct: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 544
Query: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V GPA + + ++ + A AELE+I SP ++ + + P++
Sbjct: 545 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 604
Query: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573
L S P + D+VF+LD S V F ++ FV+ +V D +V +V
Sbjct: 605 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 663
Query: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630
Y + + F L++ + ++ A+ Q LGG + G AL + ++ G+R
Sbjct: 664 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 723
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690
GVP+ ++VLT R +D P+ ++ G + +G+G ++ ++ D + +
Sbjct: 724 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 783
Query: 691 YADLRYHQDVLIE 703
+ L Q V+ E
Sbjct: 784 FRQLGTVQQVISE 796
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS +VGK +F + F + + + LDI + +RVG QFS TP EF L+++ T
Sbjct: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
Query: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165
+ ++ ++++ +GG T + L+ Y H GG VPQ+L+++T G+S+
Sbjct: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
+ L G+ F VG EL +A P
Sbjct: 352 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 386
Score = 88.2 bits (217), Expect = 2e-17
Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD SA F + FV V ++ + RVG+ +S + + YQ
Sbjct: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
Query: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
D++ L + +GG L TGSAL F T G R R ++++LLT S
Sbjct: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 348
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
ED A +L VG S+A +AELE+I +P V + D F+ +P L +
Sbjct: 349 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 404
Query: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
L + P + ++ D++F+ D SA++ + F ++ F+ + V P
Sbjct: 405 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 463
Query: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624
+ T++ + Y V+ D ++ +L + + G + G AL + +
Sbjct: 464 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 523
Query: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
G+R GV + +V+L GR ++ PA L+ +G+
Sbjct: 524 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 561
Score = 87.0 bits (214), Expect = 5e-17
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S G GF K FV+R V ++ R RV V YS + Y +
Sbjct: 622 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
Query: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
D+V ++ + GGPT TG+A LR GS G +++++LT S
Sbjct: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 737
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501
D+V P+ + + +G+G A E++ I+ G+ + V+
Sbjct: 738 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 797
Query: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
Q ++ LQ L PG + D+VF++D S S GPE F +++ +
Sbjct: 798 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 855
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620
+V D T+V ++ + + F L+ ++ + A+ + GG + G AL ++
Sbjct: 856 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 915
Query: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665
+ G+R GVP+ +V+++ G+ ++ PA +L+ G++ +
Sbjct: 916 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 962
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLDGS V G F K F V + LD+ +RVRV Q+S EF L+
Sbjct: 618 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
Query: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161
S+ +Q+V ++++ GG T T AL+++L L G R VPQ+LI++T +
Sbjct: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 736
Query: 162 SQGDVALPSKQLKERGVTVFAVGV 185
S DV PS +K G +G+
Sbjct: 737 SGDDVRNPSVVVKRGGAVPIGIGI 760
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S G F+ + + D LD+ + RV QFS P +EF L++ S+
Sbjct: 826 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
Query: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ EV+ ++R+ KGGR E + + R L VPQ L++++ GKS +
Sbjct: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 944
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
V P+ +LK+ GV F + R EEL ++ P
Sbjct: 945 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 978
Score = 74.3 bits (181), Expect = 4e-13
Identities = 45/152 (29%), Positives = 83/152 (54%), Gaps = 5/152 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL+DGS+++G +F + F V L+I + ++V Q++ T EF ++ T
Sbjct: 38 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
Query: 111 QQEVKARIKRM-VFKGGRTETELALKYL---LHRGLPGGRNA-SVPQILIIVTDGKSQGD 165
++EV +++M G T AL ++ L G R A +P++L+++T GKS +
Sbjct: 98 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALA 197
++ P+++LK + FA+G + EL +A
Sbjct: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL DGS ++ G F + F + D L++ PE R+ Q+S +E D +
Sbjct: 430 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
Query: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ E+ +KRM K G+ + A +Y+ + V Q L+++ G+S
Sbjct: 489 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 548
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211
V P+ LK+ GV F + EL + P +L AE +
Sbjct: 549 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 592
Score = 41.2 bits (95), Expect = 0.003
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 13/180 (7%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S + F + ++R V + RV V +S + V + +
Sbjct: 826 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
++ ++ + +GG + G+AL R +R GS G + +VL++ S
Sbjct: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 941
Query: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517
+DEV PA + + + A + EL +I+ SP++V S F ++P L+ KL
Sbjct: 942 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVS----TFRELPSLEQKL 997
>gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
sapiens]
Length = 1237
Score = 110 bits (274), Expect = 6e-24
Identities = 94/349 (26%), Positives = 160/349 (45%), Gaps = 32/349 (9%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S T F F+ + + + RVGV +S E + Y
Sbjct: 36 DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
++ ++ + F GG G AL E F TR G R +V+VL++ S
Sbjct: 96 KAQVLGAVKALGFAGGELANIGLALDFVVENHF---TRAGGSRVEEGVPQVLVLISAGPS 152
Query: 458 EDEVAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
DE+ + + G+G++A RAEL+ I +V++ P+ F +LQ K
Sbjct: 153 SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDN--LVFTVPE--FRSFGDLQEK 208
Query: 517 LCS-----RQR------PGCRTQAL-----DLVFMLDTSASVGPENFAQMQSFVRSCALQ 560
L QR P TQ + D+VF++D S+++G NF ++ F+ +
Sbjct: 209 LLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
Query: 561 FEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAI-SQAPYLGGVGSAGTALLHIYD 619
E+ D+ QV + Y V+ F +T PT+ ++ A+ P G G+AL + +
Sbjct: 269 LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
Query: 620 KVMTVQRG--ARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666
+ T G A G+PK +V++TGG+ ++ + PAQ+L+ + I +G
Sbjct: 329 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIG 377
Score = 110 bits (274), Expect = 6e-24
Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S+ L F + F+ + ++ + +V VA Y+ + +
Sbjct: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
Query: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459
+++ ++ + P G TGSAL F S+ R + P+ ++VL+T S D
Sbjct: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 357
Query: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516
E++ PA+ + ++ +G++ A +AELEEI V + ++ L +P L
Sbjct: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 417
Query: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
L + P + D++F+LD SA+VG NF ++ FV + ++ D +VGLV +
Sbjct: 418 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 477
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632
T F L+T T++ +L + Q GG G + G+AL ++Y T G+ R V
Sbjct: 478 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 537
Query: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
P+ +++LT G+ + A L GI VG L ++A
Sbjct: 538 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 584
Score = 100 bits (250), Expect = 4e-21
Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E + D+LFL D SA + F + F+ + + + + R+ VA YS ++ V
Sbjct: 627 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456
E+Q P+++ + + + G L G AL A F SA +D + +VLL
Sbjct: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745
Query: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515
S D V GPA + + ++ + A AELE+I SP ++ + + P++
Sbjct: 746 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 805
Query: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573
L S P + D+VF+LD S V F ++ FV+ +V D +V +V
Sbjct: 806 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 864
Query: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630
Y + + F L++ + ++ A+ Q LGG + G AL + ++ G+R
Sbjct: 865 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 924
Query: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690
GVP+ ++VLT R +D P+ ++ G + +G+G ++ ++ D + +
Sbjct: 925 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 984
Query: 691 YADLRYHQDVLIE 703
+ L Q V+ E
Sbjct: 985 FRQLGTVQQVISE 997
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FLLDGS +VGK +F + F + + + LDI + +RVG QFS TP EF L+++ T
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165
+ ++ ++++ +GG T + L+ Y H GG VPQ+L+++T G+S+
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
+ L G+ F VG EL +A P
Sbjct: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 587
Score = 88.2 bits (217), Expect = 2e-17
Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD SA F + FV V ++ + RVG+ +S + + YQ
Sbjct: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
Query: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457
D++ L + +GG L TGSAL F T G R R ++++LLT S
Sbjct: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 549
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516
ED A +L VG S+A +AELE+I +P V + D F+ +P L +
Sbjct: 550 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 605
Query: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565
L + P + ++ D++F+ D SA++ + F ++ F+ + V P
Sbjct: 606 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 664
Query: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624
+ T++ + Y V+ D ++ +L + + G + G AL + +
Sbjct: 665 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 724
Query: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660
G+R GV + +V+L GR ++ PA L+ +G+
Sbjct: 725 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 762
Score = 87.0 bits (214), Expect = 5e-17
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FLLD S G GF K FV+R V ++ R RV V YS + Y +
Sbjct: 823 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
Query: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
D+V ++ + GGPT TG+A LR GS G +++++LT S
Sbjct: 882 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 938
Query: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501
D+V P+ + + +G+G A E++ I+ G+ + V+
Sbjct: 939 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 998
Query: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
Q ++ LQ L PG + D+VF++D S S GPE F +++ +
Sbjct: 999 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 1056
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620
+V D T+V ++ + + F L+ ++ + A+ + GG + G AL ++
Sbjct: 1057 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1116
Query: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665
+ G+R GVP+ +V+++ G+ ++ PA +L+ G++ +
Sbjct: 1117 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163
Score = 84.0 bits (206), Expect = 5e-16
Identities = 50/156 (32%), Positives = 83/156 (53%), Gaps = 5/156 (3%)
Query: 49 AVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSF 108
+ DI+FL+DGSN+ G +F F + + + L I +++RVG QFS P F LD++
Sbjct: 34 SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
Query: 109 STQQEVKARIKRMVFKGGR-TETELALKYLL--HRGLPGGRNA--SVPQILIIVTDGKSQ 163
ST+ +V +K + F GG LAL +++ H GG VPQ+L++++ G S
Sbjct: 94 STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
Query: 164 GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASE 199
++ LK+ V F +G + EL +A++
Sbjct: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 189
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S D++FLLDGS V G F K F V + LD+ +RVRV Q+S EF L+
Sbjct: 819 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
Query: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161
S+ +Q+V ++++ GG T T AL+++L L G R VPQ+LI++T +
Sbjct: 878 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937
Query: 162 SQGDVALPSKQLKERGVTVFAVGV 185
S DV PS +K G +G+
Sbjct: 938 SGDDVRNPSVVVKRGGAVPIGIGI 961
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D++FL+DGS S G F+ + + D LD+ + RV QFS P +EF L++ S+
Sbjct: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
Query: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ EV+ ++R+ KGGR E + + R L VPQ L++++ GKS +
Sbjct: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200
V P+ +LK+ GV F + R EEL ++ P
Sbjct: 1146 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179
Score = 74.7 bits (182), Expect = 3e-13
Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 23/184 (12%)
Query: 19 PPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVC 78
PP++ Q + V+K DI+FL+DGS+++G +F + F V
Sbjct: 225 PPTIVTQVIEVNKR------------------DIVFLVDGSSALGLANFNAIRDFIAKVI 266
Query: 79 DGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRM-VFKGGRTETELALKYL 137
L+I + ++V Q++ T EF ++ T++EV +++M G T AL ++
Sbjct: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
Query: 138 ---LHRGLPGGRNA-SVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEEL 193
L G R A +P++L+++T GKS +++ P+++LK + FA+G + EL
Sbjct: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
Query: 194 HALA 197
+A
Sbjct: 387 EEIA 390
Score = 63.9 bits (154), Expect = 5e-10
Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 521 QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQ 580
Q+ + D++F++D S + G NFA + F+ + + + +VG+V + + +
Sbjct: 26 QQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPR 85
Query: 581 TAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--PGVPKAVV 637
T F LDT T+A +L A+ + GG + + G AL + + T G+R GVP+ +V
Sbjct: 86 TMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLV 145
Query: 638 VLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVA 689
+++ G +++ V+ + V S GL A R L H+A
Sbjct: 146 LISAGPSSDEIR----------YGVVALKQASVFSFGLGAQAASRAELQHIA 187
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI+FL DGS ++ G F + F + D L++ PE R+ Q+S +E D +
Sbjct: 631 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
Query: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165
+ E+ +KRM K G+ + A +Y+ + V Q L+++ G+S
Sbjct: 690 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 749
Query: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211
V P+ LK+ GV F + EL + P +L AE +
Sbjct: 750 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 793
Score = 41.2 bits (95), Expect = 0.003
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 13/180 (7%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
D++FL+D S + F + ++R V + RV V +S + V + +
Sbjct: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
Query: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457
++ ++ + +GG + G+AL R +R GS G + +VL++ S
Sbjct: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 1142
Query: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517
+DEV PA + + + A + EL +I+ SP++V S F ++P L+ KL
Sbjct: 1143 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVS----TFRELPSLEQKL 1198
>gi|93141049 collagen, type XII, alpha 1 short isoform precursor
[Homo sapiens]
Length = 1899
Score = 107 bits (268), Expect = 3e-23
Identities = 65/216 (30%), Positives = 112/216 (51%), Gaps = 12/216 (5%)
Query: 16 SRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAI 75
SR+PP+L + + I A A DI+ L+DGS S+G+ +F + F
Sbjct: 3 SRLPPALAALGAAL---LLSSIEAEGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFIS 59
Query: 76 TVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALK 135
+ + DI P+RV++ Q+S P E+ L++ ++ + + + +KGG T T +AL
Sbjct: 60 RIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALN 119
Query: 136 YLLHRGL--PGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEEL 193
++ + G +I +++TDGKSQ DV PSK+LK+ GV +FA+G++ EL
Sbjct: 120 FIRQQNFRTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVEL 179
Query: 194 HALASEPRGQHVL-------LAEQVEDATNGLFSTL 222
+A++P H L+ V+D T L +++
Sbjct: 180 KMIATDPDDTHAYNVADFESLSRIVDDLTINLCNSV 215
Score = 98.2 bits (243), Expect = 2e-20
Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 11/194 (5%)
Query: 48 AAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLD-ISPERVRVGAFQFSSTPHLEFPLD 106
A DI+FL D S S+G +F + F G D ISP ++V Q+S EF L+
Sbjct: 1156 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 1215
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLP--GGRNASVPQILIIVTDGKSQG 164
+++ + ++ + ++GG T T AL ++ + L G +VP++L++VTDG+SQ
Sbjct: 1216 TYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQD 1275
Query: 165 DVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSS 224
+V + +++ G +VF VGV + EL +AS+P +HV + + E F +
Sbjct: 1276 EVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFES-----FEKIED 1330
Query: 225 SAI---CSSATPDC 235
+ I C +AT C
Sbjct: 1331 NLITFVCETATSSC 1344
Score = 96.3 bits (238), Expect = 9e-20
Identities = 65/189 (34%), Positives = 97/189 (51%), Gaps = 5/189 (2%)
Query: 522 RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF-EVNPDVTQVGLVVYGSQVQ 580
R C+ D+VF+ D S S+G +NF ++ F+ + F E++P QV V Y +V+
Sbjct: 1150 RDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVK 1209
Query: 581 TAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLT 640
+ F L+T +A L A+ Y GG G AL I +KV+T + G R VPK +VV+T
Sbjct: 1210 SEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVT 1269
Query: 641 GGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYH--- 697
GR ++ A ++ +G SV VVGV V L +A + S HV D
Sbjct: 1270 DGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIAS-KPSERHVFIVDDFESFEKI 1328
Query: 698 QDVLIEWLC 706
+D LI ++C
Sbjct: 1329 EDNLITFVC 1337
Score = 87.4 bits (215), Expect = 4e-17
Identities = 55/190 (28%), Positives = 92/190 (48%), Gaps = 3/190 (1%)
Query: 525 CRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAF 583
C T+A D+V ++D S S+G NF ++SF+ F++ P Q+ L Y +T +
Sbjct: 28 CLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEW 87
Query: 584 GLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGR 643
L+ + ++L+A++ PY GG G AL I + Q G RP K V++T G+
Sbjct: 88 QLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGK 147
Query: 644 GAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDS--LIHVAAYADLRYHQDVL 701
+D P++KL++ G+ + +G+ L+ +A D +VA + L D L
Sbjct: 148 SQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 207
Query: 702 IEWLCGGEWG 711
LC G
Sbjct: 208 TINLCNSVKG 217
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/190 (26%), Positives = 90/190 (47%), Gaps = 10/190 (5%)
Query: 338 LEC----RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLV 393
+EC D++ L+D S F + F+ R V R ++ +A YS +
Sbjct: 26 MECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRT 85
Query: 394 AVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTG-QDRPRRVVVLL 452
+ ++D L+ ++ +P++GG TLTG AL ++ F T+ G + R R++ VL+
Sbjct: 86 EWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNF--RTQAGMRPRARKIGVLI 143
Query: 453 TESHSEDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVY--SDPQDLFNQ 509
T+ S+D+V P++ + + L +G A EL+ I P Y +D + L
Sbjct: 144 TDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRI 203
Query: 510 IPELQGKLCS 519
+ +L LC+
Sbjct: 204 VDDLTINLCN 213
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/245 (25%), Positives = 102/245 (41%), Gaps = 18/245 (7%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVA--TYSRELLVAVPVG 398
+ D++FL D+S D F + F+ V E S A + V+ YS E+ +
Sbjct: 1157 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGG-FDEISPAGIQVSFVQYSDEVKSEFKLN 1215
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458
Y D + +L I +RGG T TG AL E+ + ++ P +V+V++T+ S+
Sbjct: 1216 TYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVP-KVLVVVTDGRSQ 1274
Query: 459 DEVAGPARHARARELLLLGVG-SEAVRAELEEITGSP--KHVMVYSDPQDLFNQIPELQG 515
DEV A + + VG ++ EL I P +HV + D + L
Sbjct: 1275 DEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLIT 1334
Query: 516 KLCSRQRPGCRTQALDLV----FMLDTSASVGPENFAQMQ-------SFVRSCALQFEVN 564
+C C LD F + + ++ +NFA +Q SF A + + N
Sbjct: 1335 FVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRIQKN 1394
Query: 565 PDVTQ 569
V Q
Sbjct: 1395 AFVNQ 1399
>gi|21359974 vitrin [Homo sapiens]
Length = 693
Score = 103 bits (256), Expect = 7e-22
Identities = 90/387 (23%), Positives = 160/387 (41%), Gaps = 27/387 (6%)
Query: 340 CRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGE 399
C++DL FL+D S F K + +A+ + +GV Y +
Sbjct: 305 CKIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKT 364
Query: 400 YQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSED 459
+ + DL +++ I RGG + G A+ + F A P VVV++ + D
Sbjct: 365 HTNSRDLKTAIEKITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPN-VVVVMVDGWPTD 423
Query: 460 EVAGPARHARARELLLLGVGSEAVRAELEEITGSPK---------------HVMVYSDPQ 504
+V +R AR + + + E ++ P HV +
Sbjct: 424 KVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFG-- 481
Query: 505 DLFNQIPELQGKLCSRQRPGCRTQAL---DLVFMLDTSASVGPENFAQMQSFVRSCALQF 561
L + L ++C R C L D+ F++D S+SVG NF + FV + +F
Sbjct: 482 -LHKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEF 540
Query: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKV 621
E++ T++G V Y + + FG D ++ +L AI + Y G S G A+ +++
Sbjct: 541 EISDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQL 600
Query: 622 MTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA-- 679
+ ++P K ++++T GR +D +PA G+ +GV E L +A
Sbjct: 601 F---KKSKPNKRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATH 657
Query: 680 GPRDSLIHVAAYADLRYHQDVLIEWLC 706
RD V + +L + +I+ +C
Sbjct: 658 PARDHSFFVDEFDNLHQYVPRIIQNIC 684
Score = 98.6 bits (244), Expect = 2e-20
Identities = 54/172 (31%), Positives = 91/172 (52%), Gaps = 9/172 (5%)
Query: 46 CSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPL 105
C + DI F++DGS+SVG G+F F + +IS R+GA Q++ LEF
Sbjct: 505 CLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAVQYTYEQRLEFGF 564
Query: 106 DSFSTQQEVKARIKRMVFKGGRTET----ELALKYLLHRGLPGGRNASVPQILIIVTDGK 161
D +S++ ++ IKR+ + G T T AL+ L + P R +++I++TDG+
Sbjct: 565 DKYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQLFKKSKPNKR-----KLMILITDGR 619
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVED 213
S DV +P+ +GV +A+GV + EEL +A+ P H ++ ++
Sbjct: 620 SYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFVDEFDN 671
Score = 74.3 bits (181), Expect = 4e-13
Identities = 52/208 (25%), Positives = 92/208 (44%), Gaps = 15/208 (7%)
Query: 19 PPSLPLQEVHVSKETIGKISAASKMMWC-SAAVDIMFLLDGSNSVGKGSFERSKHFAITV 77
P S+ L E V KE + S + + +D+ FL+DGS S+GK F K V
Sbjct: 275 PGSVLLDEGLVPKEELSTQSLEPVSLGDPNCKIDLSFLIDGSTSIGKRRFRIQKQLLADV 334
Query: 78 CDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYL 137
LDI P +G Q+ P F L + + +++K I+++ +GG + A+ ++
Sbjct: 335 AQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGGLSNVGRAISFV 394
Query: 138 LHR--GLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHA 195
G + P +++++ DG V S+ +E G+ +F + +
Sbjct: 395 TKNFFSKANGNRSGAPNVVVVMVDGWPTDKVEEASRLARESGINIFFITIEG-------- 446
Query: 196 LASEPRGQHVL---LAEQVEDATNGLFS 220
A+E Q+V+ A + TNG +S
Sbjct: 447 -AAENEKQYVVEPNFANKAVCRTNGFYS 473
Score = 65.5 bits (158), Expect = 2e-10
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 3/145 (2%)
Query: 523 PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTA 582
P C+ +DL F++D S S+G F + + A ++ P +G+V YG T
Sbjct: 303 PNCK---IDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATH 359
Query: 583 FGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGG 642
F L T + AI + GG+ + G A+ + + G R G P VVV+ G
Sbjct: 360 FNLKTHTNSRDLKTAIEKITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPNVVVVMVDG 419
Query: 643 RGAEDAAVPAQKLRNNGISVLVVGV 667
+ ++ R +GI++ + +
Sbjct: 420 WPTDKVEEASRLARESGINIFFITI 444
>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
Length = 957
Score = 101 bits (252), Expect = 2e-21
Identities = 58/191 (30%), Positives = 106/191 (55%), Gaps = 5/191 (2%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
+A D++F+LDGS SVG +FE K + + + DI P+ ++VG Q+S P LE PL
Sbjct: 33 TAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLG 92
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDV 166
S+ + + + A ++ +++ GG T+T A+++ L L + + +I +++TDGKSQ DV
Sbjct: 93 SYDSGEHLTAAVESILYLGGNTKTGKAIQFALDY-LFAKSSRFLTKIAVVLTDGKSQDDV 151
Query: 167 ALPSKQLKERGVTVFAVGVRFPRWE-ELHALASEPRGQHVLLAEQ---VEDATNGLFSTL 222
++ ++ +T+FA+GV + EL A+A++P +V E + + L
Sbjct: 152 KDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKL 211
Query: 223 SSSAICSSATP 233
++C + P
Sbjct: 212 CEESVCPTRIP 222
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 522 RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQT 581
R CRT DLVF+LD S SVGPENF ++ ++ + F++ P QVG+V Y
Sbjct: 28 RSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVL 87
Query: 582 AFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTG 641
L + + + A+ YLGG G A+ D + + +R + K VVLT
Sbjct: 88 EIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFA--KSSR-FLTKIAVVLTD 144
Query: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEG-LRRLAGPRDS--LIHVAAYADLRYHQ 698
G+ +D AQ R++ I++ +GVG + LR +A S + +V Y + +
Sbjct: 145 GKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIR 204
Query: 699 DVLIEWLC 706
+V+ + LC
Sbjct: 205 EVMKQKLC 212
Score = 70.5 bits (171), Expect = 5e-12
Identities = 54/180 (30%), Positives = 89/180 (49%), Gaps = 8/180 (4%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402
DL+F+LD S + F K ++ + +VGV YS ++ +P+G Y
Sbjct: 37 DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96
Query: 403 VPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVA 462
L +++ I + GG T TG A++ A + F ++R ++ V+LT+ S+D+V
Sbjct: 97 GEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRF----LTKIAVVLTDGKSQDDVK 152
Query: 463 GPARHARARELLL--LGVGSEAVRAELEEITGSPKHVMV-YSDPQDLFNQIPE-LQGKLC 518
A+ AR ++ L +GVGSE AEL I P V Y + ++I E ++ KLC
Sbjct: 153 DAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLC 212
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 99.8 bits (247), Expect = 8e-21
Identities = 68/203 (33%), Positives = 109/203 (53%), Gaps = 24/203 (11%)
Query: 5 LLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGK 64
LL+ A+C + + P ++ H + T ++ AA DI+FLLDGS+S+G+
Sbjct: 5 LLVAALCAGILAEAPR---VRAQHRERVTCTRLYAA----------DIVFLLDGSSSIGR 51
Query: 65 GSFERSKHFAITVCDGLDI------SPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARI 118
+F + F +GL + S + VR Q+S P EF LD+ + +V I
Sbjct: 52 SNFREVRSFL----EGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGDVIRAI 107
Query: 119 KRMVFKGGRTETELALKYLL-HRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERG 177
+ + +KGG T T A+ ++ H LP VP++ I++TDGKSQ V +++LK +G
Sbjct: 108 RELSYKGGNTRTGAAILHVADHVFLPQLARPGVPKVCILITDGKSQDLVDTAAQRLKGQG 167
Query: 178 VTVFAVGVRFPRWEELHALASEP 200
V +FAVG++ EEL +AS+P
Sbjct: 168 VKLFAVGIKNADPEELKRVASQP 190
Score = 99.4 bits (246), Expect = 1e-20
Identities = 58/163 (35%), Positives = 88/163 (53%), Gaps = 4/163 (2%)
Query: 520 RQRPGC-RTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFE--VNPDVTQVGLVVYG 576
R+R C R A D+VF+LD S+S+G NF +++SF+ L F + + V Y
Sbjct: 26 RERVTCTRLYAADIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYS 85
Query: 577 SQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAV 636
+T FGLD + ++RAI + Y GG G A+LH+ D V Q ARPGVPK
Sbjct: 86 DDPRTEFGLDALGSGGDVIRAIRELSYKGGNTRTGAAILHVADHVFLPQL-ARPGVPKVC 144
Query: 637 VVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
+++T G+ + AQ+L+ G+ + VG+ E L+R+A
Sbjct: 145 ILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVA 187
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/257 (24%), Positives = 104/257 (40%), Gaps = 20/257 (7%)
Query: 483 VRAELEEITGSPKHVMVYSDPQD----------LFNQIPELQG----KLCSRQRPGCRTQ 528
+R +E+ GSP+ + S Q +F+ P L G + Q P C
Sbjct: 992 LRGPGQEVPGSPQTLPGISSSQRVTGLEPGVSYIFSLTPVLDGVRGPEASVTQTPVCPRG 1051
Query: 529 ALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTK 588
D+VF+ + A + R + P QVGL+ Y + F L+
Sbjct: 1052 LADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPLFPLNGS 1111
Query: 589 PTRAAMLRAISQAPYLGGVGS-AGTALLHIYDKVMTVQR-GARPGVPKAVVVLTGGRGAE 646
+L+ I PY+ G+ GTA++ + ++ G R VP +V+L
Sbjct: 1112 HDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGRRQHVPGVMVLLVDEPLRG 1171
Query: 647 DAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYAD---LRYHQDVLIE 703
D P ++ + +G++V+++G+ E LRRLA DS+ A D L L
Sbjct: 1172 DIFSPIREAQASGLNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQAVSGLAT 1231
Query: 704 WLCGGEW-GNPHPQGCP 719
LC + P P+ CP
Sbjct: 1232 ALCQASFTTQPRPEPCP 1248
Score = 50.1 bits (118), Expect = 7e-06
Identities = 39/161 (24%), Positives = 72/161 (44%), Gaps = 10/161 (6%)
Query: 83 ISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVF---KGGRTETEL--ALKYL 137
+ P+ V+VG +S P FPL+ + RI+ M + G T + A +Y+
Sbjct: 1086 LGPQAVQVGLLSYSHRPSPLFPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYM 1145
Query: 138 LHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALA 197
L PG R VP +++++ D +GD+ P ++ + G+ V +G+ E+L LA
Sbjct: 1146 LAPDAPG-RRQHVPGVMVLLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLA 1204
Query: 198 SEPRGQHVLLA----EQVEDATNGLFSTLSSSAICSSATPD 234
A ++ A +GL + L ++ + P+
Sbjct: 1205 PGMDSVQTFFAVDDGPSLDQAVSGLATALCQASFTTQPRPE 1245
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/182 (23%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVAT--YSRELLVAVPVGEY 400
D++FLLD S+ F + F++ V S V AT YS + +
Sbjct: 38 DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97
Query: 401 QDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDE 460
D++ ++ + ++GG T TG+A+ A+ F + + +V +L+T+ S+D
Sbjct: 98 GSGGDVIRAIRELSYKGGNTRTGAAILHVADHVF--LPQLARPGVPKVCILITDGKSQDL 155
Query: 461 VAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVY--SDPQDLFNQIPELQGKL 517
V A+ + + + L VG A EL+ + P + +D L +P + ++
Sbjct: 156 VDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRV 215
Query: 518 CS 519
C+
Sbjct: 216 CT 217
>gi|205277471 cochlin precursor [Homo sapiens]
Length = 550
Score = 94.7 bits (234), Expect = 3e-19
Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 3/183 (1%)
Query: 31 KETIGKISAASKMMW---CSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPER 87
K + K+ +MM C +V+I FL+DGS+SVG +F F + +IS
Sbjct: 344 KPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG 403
Query: 88 VRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRN 147
++ A QF+ EF +ST++ V A I+ + + G T T A+ + + R
Sbjct: 404 AKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRE 463
Query: 148 ASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLL 207
+ L+IVTDG+S DV P+ + G+T+F+VGV + ++L +AS+P+ H
Sbjct: 464 SPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF 523
Query: 208 AEQ 210
+
Sbjct: 524 TRE 526
Score = 90.5 bits (223), Expect = 5e-18
Identities = 87/362 (24%), Positives = 157/362 (43%), Gaps = 19/362 (5%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
+C+ D+ FL+D S F K FV + + VG+ S + +
Sbjct: 161 DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLK 220
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458
+ D+++++ + FRGG + TG AL+ A++ F + P+ VVV + S+
Sbjct: 221 NFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD 280
Query: 459 D-EVAGPARHARARELLLLGVGSEAVRAEL---EEITGSPKHV------MVYSDPQ--DL 506
D E AG + ++ V ++ + EL +++T K V Y P
Sbjct: 281 DIEEAGIVAREFGVNVFIVSV-AKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
Query: 507 FNQIPELQGKLCSRQRPGCRT---QALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563
+ L KLC+ ++ C ++++ F++D S+SVG NF M FV + A FE+
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
Query: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMT 623
+ ++ V + +T F T+ +L I Y+ G + G A+ V
Sbjct: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG 459
Query: 624 VQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PR 682
R + +V++T G+ +D PA + GI++ VGV + L+ +A P+
Sbjct: 460 PIRESPN--KNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPK 517
Query: 683 DS 684
+S
Sbjct: 518 ES 519
Score = 82.4 bits (202), Expect = 1e-15
Identities = 56/172 (32%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI FL+DGS ++G+ F K+F V L I E VG Q S P +EF L +F++
Sbjct: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHR--GLPGGRNASVPQILIIVTDGKSQGDVAL 168
++V IK + F+GG + T ALK+ + + G +P+++++ DG D+
Sbjct: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEE 284
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFS 220
+E GV VF V V P EEL + Q V ++ NG FS
Sbjct: 285 AGIVAREFGVNVFIVSVAKPIPEELGMV------QDVTFVDKAVCRNNGFFS 330
Score = 75.1 bits (183), Expect = 2e-13
Identities = 47/160 (29%), Positives = 72/160 (45%)
Query: 516 KLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
K ++ G + D+ F++D S ++G F ++FV AL + + VGLV
Sbjct: 150 KKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA 209
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKA 635
+ F L + +L AI + + GG + G AL H K TV G R G+PK
Sbjct: 210 SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKV 269
Query: 636 VVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGL 675
VVV G ++D R G++V +V V + E L
Sbjct: 270 VVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
>gi|4758022 cochlin precursor [Homo sapiens]
Length = 550
Score = 94.7 bits (234), Expect = 3e-19
Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 3/183 (1%)
Query: 31 KETIGKISAASKMMW---CSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPER 87
K + K+ +MM C +V+I FL+DGS+SVG +F F + +IS
Sbjct: 344 KPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG 403
Query: 88 VRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRN 147
++ A QF+ EF +ST++ V A I+ + + G T T A+ + + R
Sbjct: 404 AKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRE 463
Query: 148 ASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLL 207
+ L+IVTDG+S DV P+ + G+T+F+VGV + ++L +AS+P+ H
Sbjct: 464 SPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF 523
Query: 208 AEQ 210
+
Sbjct: 524 TRE 526
Score = 90.5 bits (223), Expect = 5e-18
Identities = 87/362 (24%), Positives = 157/362 (43%), Gaps = 19/362 (5%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
+C+ D+ FL+D S F K FV + + VG+ S + +
Sbjct: 161 DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLK 220
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458
+ D+++++ + FRGG + TG AL+ A++ F + P+ VVV + S+
Sbjct: 221 NFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD 280
Query: 459 D-EVAGPARHARARELLLLGVGSEAVRAEL---EEITGSPKHV------MVYSDPQ--DL 506
D E AG + ++ V ++ + EL +++T K V Y P
Sbjct: 281 DIEEAGIVAREFGVNVFIVSV-AKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
Query: 507 FNQIPELQGKLCSRQRPGCRT---QALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563
+ L KLC+ ++ C ++++ F++D S+SVG NF M FV + A FE+
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
Query: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMT 623
+ ++ V + +T F T+ +L I Y+ G + G A+ V
Sbjct: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG 459
Query: 624 VQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PR 682
R + +V++T G+ +D PA + GI++ VGV + L+ +A P+
Sbjct: 460 PIRESPN--KNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPK 517
Query: 683 DS 684
+S
Sbjct: 518 ES 519
Score = 82.4 bits (202), Expect = 1e-15
Identities = 56/172 (32%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
DI FL+DGS ++G+ F K+F V L I E VG Q S P +EF L +F++
Sbjct: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHR--GLPGGRNASVPQILIIVTDGKSQGDVAL 168
++V IK + F+GG + T ALK+ + + G +P+++++ DG D+
Sbjct: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEE 284
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFS 220
+E GV VF V V P EEL + Q V ++ NG FS
Sbjct: 285 AGIVAREFGVNVFIVSVAKPIPEELGMV------QDVTFVDKAVCRNNGFFS 330
Score = 75.1 bits (183), Expect = 2e-13
Identities = 47/160 (29%), Positives = 72/160 (45%)
Query: 516 KLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575
K ++ G + D+ F++D S ++G F ++FV AL + + VGLV
Sbjct: 150 KKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA 209
Query: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKA 635
+ F L + +L AI + + GG + G AL H K TV G R G+PK
Sbjct: 210 SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKV 269
Query: 636 VVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGL 675
VVV G ++D R G++V +V V + E L
Sbjct: 270 VVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
>gi|11321565 matrilin 3 precursor [Homo sapiens]
Length = 486
Score = 93.2 bits (230), Expect = 8e-19
Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 15/206 (7%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S +D++F++D S SV F + K F + D LDI P RV ++ST +EF L
Sbjct: 79 SRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQ 138
Query: 107 SFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGL---PGGR--NASVPQILIIVTDGK 161
+++ +Q +K + R+ T + LA++ + G R ++++P++ IIVTDG+
Sbjct: 139 AYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGR 198
Query: 162 SQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFST 221
Q V + + + G+ ++AVGV L +ASEP +HV E T G+
Sbjct: 199 PQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVE-----TYGVIEK 253
Query: 222 LSS---SAICSSATPDCRVEAHPCEH 244
LSS C A C + H C+H
Sbjct: 254 LSSRFQETFC--ALDPCVLGTHQCQH 277
Score = 78.2 bits (191), Expect = 3e-14
Identities = 46/158 (29%), Positives = 82/158 (51%), Gaps = 3/158 (1%)
Query: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
C+++ LDLVF++D+S SV P F ++++FV ++ P T+V +V Y S V+ F
Sbjct: 77 CKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQ 136
Query: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGAR---PGVPKAVVVLTG 641
L + ++ +A+ + L +G A+ D+ TV+ GAR +PK +++T
Sbjct: 137 LQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTD 196
Query: 642 GRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679
GR + A + + +GI + VGV L+ +A
Sbjct: 197 GRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMA 234
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/162 (24%), Positives = 72/162 (44%), Gaps = 3/162 (1%)
Query: 342 VDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQ 401
+DL+F++DSS F + K FV R + + + RV V Y+ + + + Y
Sbjct: 82 LDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYT 141
Query: 402 DVPDLVWSLDGIPFRGGPTLTGSALRQAAERGF--GSATRTGQDRPRRVVVLLTESHSED 459
D L ++ I T++G A++ A + F + R +V +++T+ +D
Sbjct: 142 DKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201
Query: 460 EVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVY 500
+V A A+A + L VG A A L+ + P V+
Sbjct: 202 QVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVF 243
>gi|40068485 von Willebrand factor A domain containing 1 isoform 1
[Homo sapiens]
Length = 445
Score = 82.8 bits (203), Expect = 1e-15
Identities = 53/157 (33%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Query: 51 DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110
D+MFLLD S SV F R + F + L + +R S P+ EFP S+
Sbjct: 34 DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93
Query: 111 QQEVKARIKRMVFKGGRTETELALKYLLHR--GLPGGRNASVPQILIIVTDGKSQGDVAL 168
+ + ++ + G T T LAL Y + G VP++L+ VTDG S V
Sbjct: 94 GEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGP 153
Query: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHV 205
P ++LK+ GVTVF V + EL A AS P +H+
Sbjct: 154 PMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHL 190
Score = 73.2 bits (178), Expect = 8e-13
Identities = 42/138 (30%), Positives = 70/138 (50%)
Query: 531 DLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPT 590
DL+F+LD+SASV F++++ FV + + LV GS+ T F +
Sbjct: 34 DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93
Query: 591 RAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAV 650
A A+ + G G AL++ +++ GARPGVPK +V +T G ++
Sbjct: 94 GEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGP 153
Query: 651 PAQKLRNNGISVLVVGVG 668
P Q+L++ G++V +V G
Sbjct: 154 PMQELKDLGVTVFIVSTG 171
Score = 50.4 bits (119), Expect = 6e-06
Identities = 56/191 (29%), Positives = 79/191 (41%), Gaps = 15/191 (7%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEY 400
R DL+FLLDSSA + F R + FV + V + R + P G++
Sbjct: 32 RGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQH 91
Query: 401 QDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDE 460
++ R G T TG AL A E+ F A+ P +V+V +T+ S D
Sbjct: 92 SSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVP-KVLVWVTDGGSSDP 150
Query: 461 VAGPARHARARELLLLGVGSEAVRA------ELEEITGSP--KHVMVYSDPQDLFNQIPE 512
V P +EL LGV V EL +P KH + + D DL + E
Sbjct: 151 VGPP-----MQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKH-LHFVDVDDLHIIVQE 204
Query: 513 LQGKLCSRQRP 523
L+G + RP
Sbjct: 205 LRGSILDAMRP 215
>gi|31657142 integrin, alpha 1 precursor [Homo sapiens]
Length = 1179
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/217 (26%), Positives = 103/217 (47%), Gaps = 18/217 (8%)
Query: 33 TIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGA 92
T +++ + + CS +DI+ +LDGSNS+ ++ F + + +DI P++ +VG
Sbjct: 154 TFQVVNSIAPVQECSTQLDIVIVLDGSNSIYP--WDSVTAFLNDLLERMDIGPKQTQVGI 211
Query: 93 FQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGR-TETELALKYLLHRGLPGGRNA--S 149
Q+ EF L+ +S+ +EV K++V +GGR T T L + R A
Sbjct: 212 VQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRG 271
Query: 150 VPQILIIVTDGKSQGDVALPS--KQLKERGVTVFAVGV--RFPRW--------EELHALA 197
V ++++IVTDG+S + L + ++ + F++ + + R EE+ ++A
Sbjct: 272 VKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIA 331
Query: 198 SEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPD 234
SEP +H E A + TL AT D
Sbjct: 332 SEPTEKHFFNVSD-ELALVTIVKTLGERIFALEATAD 367
Score = 53.9 bits (128), Expect = 5e-07
Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 525 CRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFG 584
C TQ LD+V +LD S S+ P + + +F+ + ++ P TQVG+V YG V F
Sbjct: 167 CSTQ-LDIVIVLDGSNSIYP--WDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFN 223
Query: 585 LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDK-VMTVQRGARPGVPKAVVVLTGGR 643
L+ + +L A + GG + + K T RGAR GV K +V++T G
Sbjct: 224 LNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGE 283
Query: 644 GAED 647
++
Sbjct: 284 SHDN 287
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 71.2 bits (173), Expect = 3e-12
Identities = 56/197 (28%), Positives = 94/197 (47%), Gaps = 13/197 (6%)
Query: 478 VGSEAVRAELEEITGSPKHVMVYSDPQDLF---NQIPELQGKLCSRQRPGCRTQALDLVF 534
VG + + E+ E GSP + DL +I +L ++C P C+ L+LVF
Sbjct: 744 VGKKGDKGEIGE-PGSPGKQGLQGPKGDLGLTKEEIIKLITEICGCG-PKCKETPLELVF 801
Query: 535 MLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAM 594
++D+S SVGPENF +++FV++ A + ++ ++G++ Y +V+ L ++
Sbjct: 802 VIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEKVANLKQFSSKDDF 861
Query: 595 LRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGG----RGAEDAAV 650
A+ YLG TAL D + ARPGV K +V+T G R E
Sbjct: 862 KLAVDNMQYLGEGTYTATALQAAND----MFEDARPGVKKVALVITDGQTDSRDKEKLTE 917
Query: 651 PAQKLRNNGISVLVVGV 667
+ + + + V+GV
Sbjct: 918 VVKNASDTNVEIFVIGV 934
Score = 54.7 bits (130), Expect = 3e-07
Identities = 42/170 (24%), Positives = 81/170 (47%), Gaps = 21/170 (12%)
Query: 50 VDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFS 109
++++F++D S SVG +F+ K+F T+ D + + R+G +S L FS
Sbjct: 797 LELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEKVANLKQFS 856
Query: 110 TQQEVKARIKRMVFKGGRTETELALKY---LLHRGLPGGRNASVPQILIIVTDGKSQG-- 164
++ + K + M + G T T AL+ + PG V ++ +++TDG++
Sbjct: 857 SKDDFKLAVDNMQYLGEGTYTATALQAANDMFEDARPG-----VKKVALVITDGQTDSRD 911
Query: 165 --DVALPSKQLKERGVTVFAVGV---RFPRWE----ELHALASEPRGQHV 205
+ K + V +F +GV P +E E++ +A++P +HV
Sbjct: 912 KEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDP--EHV 959
Score = 51.6 bits (122), Expect = 3e-06
Identities = 50/191 (26%), Positives = 86/191 (45%), Gaps = 19/191 (9%)
Query: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398
E ++L+F++DSS + F K FVK V + + AR+G+ YS ++ +
Sbjct: 794 ETPLELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEKVANLK 853
Query: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVV-LLTESHS 457
++ D ++D + + G T T +AL QAA F A R G + V+ T+S
Sbjct: 854 QFSSKDDFKLAVDNMQYLGEGTYTATAL-QAANDMFEDA-RPGVKKVALVITDGQTDSRD 911
Query: 458 EDEVAGPARHARAR--ELLLLGV------GSEAVRAELEEITGSPKHVMVYSD------- 502
++++ ++A E+ ++GV E E+ I P+HV + D
Sbjct: 912 KEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDPEHVYQFDDFFTLQDT 971
Query: 503 -PQDLFNQIPE 512
Q LF +I E
Sbjct: 972 LKQKLFQKICE 982
Score = 35.8 bits (81), Expect = 0.14
Identities = 60/241 (24%), Positives = 100/241 (41%), Gaps = 49/241 (20%)
Query: 512 ELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQ-FEVNP----- 565
++QG +C +D+VF++D+S S F + + FV S + + F++ P
Sbjct: 39 DVQGSICF----------IDIVFIVDSSESSKIALFDKQKDFVDSLSDKIFQLTPGRSLE 88
Query: 566 -DVTQVGLVVYGS-QVQTAFG----LDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYD 619
D+ L S Q+ F L T + + I Q + S T LL
Sbjct: 89 YDIKLAALQFSSSVQIDPPFSSWKDLQTFKQKVKSMNLIGQGTFSYYAISNATRLLK--- 145
Query: 620 KVMTVQRGARPGVPKAVVVLTGG---RGAEDAAVPAQKLRNNGISVLVVGVGPVLSEG-L 675
+ G + GV K V+++T G D ++ R +GIS + + + V++E L
Sbjct: 146 -----REGRKDGV-KVVLLMTDGIDHPKNPDVQSISEDARISGISFITIALSTVVNEAKL 199
Query: 676 RRLAGPRDS----LIHVAAYAD-LRYHQDVLIEWLC--------GGEWGNPHPQGCPHGR 722
R ++G S L+ D ++ D+L E C G+ G+P P G HG
Sbjct: 200 RLISGDSSSEPTLLLSDPTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPG-THGN 258
Query: 723 P 723
P
Sbjct: 259 P 259
Score = 31.2 bits (69), Expect = 3.5
Identities = 42/202 (20%), Positives = 86/202 (42%), Gaps = 20/202 (9%)
Query: 340 CRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVL------SEDSRARVGVATYSRELLV 393
C +D++F++DSS + + F + K FV + S + ++ +S + +
Sbjct: 45 CFIDIVFIVDSSESSKIALFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLAALQFSSSVQI 104
Query: 394 AVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLT 453
P ++D+ + + G T + A+ A R G+ +VV+L+T
Sbjct: 105 DPPFSSWKDLQTFKQKVKSMNLIGQGTFSYYAISNATR----LLKREGRKDGVKVVLLMT 160
Query: 454 E--SHSED-EVAGPARHARARELLLLGVGSEAV--RAELEEITG--SPKHVMVYSDP--- 503
+ H ++ +V + AR + + + V A+L I+G S + ++ SDP
Sbjct: 161 DGIDHPKNPDVQSISEDARISGISFITIALSTVVNEAKLRLISGDSSSEPTLLLSDPTLV 220
Query: 504 QDLFNQIPELQGKLCSRQRPGC 525
+ +++ L K C R+ C
Sbjct: 221 DKIQDRLDILFEKKCERKICEC 242
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 63.5 bits (153), Expect = 6e-10
Identities = 46/175 (26%), Positives = 84/175 (48%), Gaps = 10/175 (5%)
Query: 47 SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106
S ++++FL+D S+SVG+ +F F + + P RV FSS ++ +D
Sbjct: 79 SERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVD 138
Query: 107 SFSTQQE-------VKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTD 159
ST++ + I + ++GG T T+ A + L N++ +++ ++TD
Sbjct: 139 YISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENST--KVVFLITD 196
Query: 160 GKSQGDVALP-SKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVED 213
G S G P + L++ GV +F G+ EL+ +AS P+ +H L E+
Sbjct: 197 GYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEE 251
Score = 58.2 bits (139), Expect = 3e-08
Identities = 44/149 (29%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 527 TQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLD 586
++ L+LVF++D S+SVG NF FVR F V P T+V +V + S+ +D
Sbjct: 79 SERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVD 138
Query: 587 TKPTR-------AAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVL 639
TR A +L+ I Y GG GT + + + AR K V ++
Sbjct: 139 YISTRRARQHKCALLLQEIPAISYRGG----GTYTKGAFQQAAQILLHARENSTKVVFLI 194
Query: 640 TGG-RGAEDAAVPAQKLRNNGISVLVVGV 667
T G D A LR++G+ + G+
Sbjct: 195 TDGYSNGGDPRPIAASLRDSGVEIFTFGI 223
Score = 43.5 bits (101), Expect = 7e-04
Identities = 43/172 (25%), Positives = 76/172 (44%), Gaps = 20/172 (11%)
Query: 341 RVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEY 400
R++L+FL+D S+ F +FV++ + + RV + T+S + V VP +Y
Sbjct: 81 RLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYV-VPRVDY 139
Query: 401 --------QDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLL 452
L+ + I +RGG T T A +QAA+ ++ +VV L+
Sbjct: 140 ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQ-----ILLHARENSTKVVFLI 194
Query: 453 TESHSED----EVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVY 500
T+ +S +A R + E+ G+ +R EL ++ +PK Y
Sbjct: 195 TDGYSNGGDPRPIAASLRDSGV-EIFTFGIWQGNIR-ELNDMASTPKEEHCY 244
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/43 (44%), Positives = 29/43 (67%), Gaps = 3/43 (6%)
Query: 299 CDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECR 341
C SQPC+NG TC +G + ++CLC F G ++C L ++ EC+
Sbjct: 1349 CLSQPCKNGATC-KDGANSFRCLCAAGFTG-SHCELNIN-ECQ 1388
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 10/46 (21%)
Query: 299 CDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDL 344
C PC N GTC G GY CLCPL + G L+C D+
Sbjct: 1197 CFFNPCHNSGTCQQLGR-GYVCLCPLGYTG---------LKCETDI 1232
Score = 35.8 bits (81), Expect = 0.14
Identities = 18/43 (41%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Query: 299 CDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECR 341
C S PC N G CV +G+ GY+C C F G +C +++ EC+
Sbjct: 1273 CSSSPCLNKGICV-DGVAGYRCTCVKGFVG-LHCETEVN-ECQ 1312
Score = 35.8 bits (81), Expect = 0.14
Identities = 15/31 (48%), Positives = 18/31 (58%), Gaps = 1/31 (3%)
Query: 299 CDSQPCQNGGTCVPEGLDGYQCLCPLAFGGE 329
C S PC+N TCV E L+ Y C C F G+
Sbjct: 1387 CQSNPCRNQATCVDE-LNSYSCKCQPGFSGK 1416
Score = 30.4 bits (67), Expect = 6.0
Identities = 15/34 (44%), Positives = 16/34 (47%), Gaps = 4/34 (11%)
Query: 295 CPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGG 328
C P PC NGG CV YQC CP + G
Sbjct: 3499 CEEPICILPCLNGGRCVAP----YQCDCPPGWTG 3528
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,348,617
Number of Sequences: 37866
Number of extensions: 1382133
Number of successful extensions: 4062
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 3023
Number of HSP's gapped (non-prelim): 725
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.