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Search of human proteins with 30795242
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795242 aryl hydrocarbon receptor nuclear translocator
isoform 3 [Homo sapiens]
(774 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 1574 0.0
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 1564 0.0
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 862 0.0
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 623 e-178
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 327 2e-89
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 297 2e-80
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 144 4e-34
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 133 5e-31
gi|4758010 clock [Homo sapiens] 130 6e-30
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 129 1e-29
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 129 1e-29
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 110 4e-24
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 110 6e-24
gi|21614542 single-minded homolog 1 [Homo sapiens] 106 9e-23
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 101 3e-21
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 100 4e-21
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 97 4e-20
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 93 8e-19
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 88 3e-17
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 77 8e-14
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 77 8e-14
gi|194097341 period 1 [Homo sapiens] 75 2e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 74 4e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 74 4e-13
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 74 4e-13
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 74 4e-13
gi|12707562 period 2 [Homo sapiens] 69 1e-11
gi|8567388 period 3 [Homo sapiens] 69 2e-11
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 1574 bits (4075), Expect = 0.0
Identities = 774/774 (100%), Positives = 774/774 (100%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 120
RCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA
Sbjct: 61 RCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 120
Query: 121 VSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTP 180
VSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTP
Sbjct: 121 VSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTP 180
Query: 181 VLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRM 240
VLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRM
Sbjct: 181 VLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRM 240
Query: 241 CMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 300
CMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW
Sbjct: 241 CMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 300
Query: 301 PPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTF 360
PPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTF
Sbjct: 301 PPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTF 360
Query: 361 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE 420
VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE
Sbjct: 361 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE 420
Query: 421 WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG 480
WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG
Sbjct: 421 WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG 480
Query: 481 SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDP 540
SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDP
Sbjct: 481 SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDP 540
Query: 541 RFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPS 600
RFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPS
Sbjct: 541 RFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPS 600
Query: 601 ASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSS 660
ASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSS
Sbjct: 601 ASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSS 660
Query: 661 FSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPH 720
FSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPH
Sbjct: 661 FSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPH 720
Query: 721 HRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE 774
HRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE
Sbjct: 721 HRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE 774
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 1564 bits (4049), Expect = 0.0
Identities = 774/789 (98%), Positives = 774/789 (98%), Gaps = 15/789 (1%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFAR---------------ENHSEIERRRRNKMTAYITELSDMVPTCS 105
RCDDDQMSNDKERFAR ENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
Query: 106 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 165
ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
Query: 166 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 225
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
Query: 226 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 285
TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
Query: 286 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 345
PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP 360
Query: 346 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 405
TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG
Sbjct: 361 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420
Query: 406 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 465
QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ
Sbjct: 421 QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ 480
Query: 466 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK
Sbjct: 481 RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
Query: 526 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 585
PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF
Sbjct: 541 PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF 600
Query: 586 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 645
RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT
Sbjct: 601 RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT 660
Query: 646 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 705
RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA
Sbjct: 661 RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA 720
Query: 706 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 765
EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD
Sbjct: 721 EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD 780
Query: 766 LTMFPPFSE 774
LTMFPPFSE
Sbjct: 781 LTMFPPFSE 789
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 862 bits (2228), Expect = 0.0
Identities = 470/782 (60%), Positives = 570/782 (72%), Gaps = 89/782 (11%)
Query: 8 PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
PEM SD+P + P A+G ++ GA+ R KRR G+DFDD DGEG SKF
Sbjct: 10 PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63
Query: 62 CDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 121
+RENHSEIERRRRNKMT YITELSDMVPTCSALARKPDKLTILRMAV
Sbjct: 64 -------------SRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAV 110
Query: 122 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181
SHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+ ETGRV+YVSDSVTPV
Sbjct: 111 SHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPV 170
Query: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241
LNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKTGTVKKEGQQSSMRMC
Sbjct: 171 LNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMC 230
Query: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301
MGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE + VVHCTGYIKAWP
Sbjct: 231 MGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWP 290
Query: 302 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 361
PAG+++P++D + GQGSK+CLVAIGRLQVTSSP C DM+ + PTEF+SRHN +GI TFV
Sbjct: 291 PAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFV 350
Query: 362 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 421
D RC++ +GYQPQ+LLGK+I+EFCHPEDQ LR+SFQQVVKLKGQVLSVM+RFR+KN+EW
Sbjct: 351 DPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREW 410
Query: 422 LWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
+ +RTSSFTFQNPYSDEIEYIICTNTNVK
Sbjct: 411 MLIRTSSFTFQNPYSDEIEYIICTNTNVK------------------------------- 439
Query: 482 GQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTG-PEHSKPLEKSDGLFAQDRDP 540
+ QQQQ EL+ V RDGL+SY+ SQV P G E K +EK+D +F+Q+RDP
Sbjct: 440 -----QLQQQQAELE-VHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDP 493
Query: 541 RFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGL-APPVTIVQP 599
RF+E++ I+A + K +SS++ TQQ++SQG+ F P+ + F +S + P V +Q
Sbjct: 494 RFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPF-PSGHSGKAFSSSVVHVPGVNDIQS 552
Query: 600 SASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQT-- 657
S+S GQ ++QISR N +Q A WT +R F QQ+ +Q ++KT++S FG+G+ T
Sbjct: 553 SSSTGQNMSQISRQLNQSQVA---WT-GSRPPFPGQQIPSQ-SSKTQSSPFGIGTSHTYP 607
Query: 658 --PSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQ 715
PSS+S +S P T+SP AY SL NR FA E+GQ++GQFQ R +E VW QWQ
Sbjct: 608 ADPSSYSPLSSPA--TSSPSGNAYSSLANRTPGFA-ESGQSSGQFQGRPSE---VWSQWQ 661
Query: 716 GQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQ---SNSYNNEEFPDLTMFPPF 772
Q HH S EQH QQPGQ EVFQ+ML M GD + +YN E+F DL MFPPF
Sbjct: 662 SQ--HHGQQSGEQHSH----QQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPF 715
Query: 773 SE 774
SE
Sbjct: 716 SE 717
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 623 bits (1607), Expect = e-178
Identities = 312/327 (95%), Positives = 312/327 (95%), Gaps = 15/327 (4%)
Query: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
Query: 61 RCDDDQMSNDKERFAR---------------ENHSEIERRRRNKMTAYITELSDMVPTCS 105
RCDDDQMSNDKERFAR ENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61 RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
Query: 106 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 165
ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
Query: 166 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 225
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
Query: 226 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 285
TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
Query: 286 PHFVVVHCTGYIKAWPPAGVSLPDDDP 312
PHFVVVHCTGYIKAWPPAGVSLPDDDP
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 75 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 134
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 30 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89
Query: 135 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 194
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 90 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149
Query: 195 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 253
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209
Query: 254 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 313
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 260
Query: 314 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 372
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 261 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 320
Query: 373 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 432
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 321 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 380
Query: 433 NPYSDEIEYIICTNTNV 449
NP++ E+EYI+ TNT V
Sbjct: 381 NPWTKEVEYIVSTNTVV 397
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 75 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 134
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
Query: 135 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 194
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
Query: 195 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 253
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
Query: 254 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 313
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
Query: 314 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 372
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
Query: 373 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 432
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
Query: 433 NPYSDEIEYIICTNTNV 449
NP++ E+EYI+ TNT V
Sbjct: 424 NPWTKEVEYIVSTNTVV 440
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 75 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 134
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
Query: 135 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 194
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
Query: 195 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 253
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
Query: 254 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 313
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
Query: 314 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 372
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
Query: 373 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 432
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
Query: 433 NPYSDEIEYIICTNTNV 449
NP++ E+EYI+ TNT V
Sbjct: 424 NPWTKEVEYIVSTNTVV 440
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 297 bits (761), Expect = 2e-80
Identities = 161/386 (41%), Positives = 238/386 (61%), Gaps = 14/386 (3%)
Query: 71 KERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 130
K + RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G
Sbjct: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
Query: 131 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
N+ +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN Q+
Sbjct: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223
Query: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 249
G +L+D +HP DV K++EQLS+ + + +++D KTG V R+ GSRRSF
Sbjct: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283
Query: 250 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 309
CR++ SV + C S K F +HCTGY+++WPP V + +
Sbjct: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
Query: 310 DDPEAGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 368
+ S F CLVAIGRLQ P + NV +PTEFI+R + G F +VD R A
Sbjct: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV-KPTEFITRFAVNGKFVYVDQRATAI 391
Query: 369 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 428
+GY PQELLG + E+ H +D L D + V++ K ++L+ ++FR+K+ ++ +++
Sbjct: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451
Query: 429 FTFQNPYSDEIEYIICTNTNVKNSSQ 454
F+F NP++ E+EYI+ NT V S+
Sbjct: 452 FSFTNPWTKELEYIVSVNTLVLGHSE 477
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 144 bits (362), Expect = 4e-34
Identities = 147/559 (26%), Positives = 240/559 (42%), Gaps = 78/559 (13%)
Query: 69 NDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HM 124
++K+R R + ++ E++RR++ I ELS M+P RK DK T+L + H
Sbjct: 4 DEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHN 60
Query: 125 KSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQ 184
+ T +KPSFL+++E L+LEA DGF+ V+ + G ++YVSDS+TP+L
Sbjct: 61 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGH 119
Query: 185 PQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGS 244
S+ L + + + ++ + LS+ L T + E +S S
Sbjct: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHM---------LVTDSPSPEYLKSD------S 164
Query: 245 RRSFICRMRCGSSSVDPV-SVNRLSFVRN-RCRNGLGSVKDGEPHFVVVHCTGYIKAWP- 301
F C + GS + + + FV N R N + S C G+
Sbjct: 165 DLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPS----------CNGFDNTLSR 214
Query: 302 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFTF 360
P V L G + C +A RL +M V +P E F SRH++E F F
Sbjct: 215 PCRVPL---------GKEVCFIATVRLATPQF--LKEMCIVDEPLEEFTSRHSLEWKFLF 263
Query: 361 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE 420
+DHR +GY P E+LG + ++ H +D +LL Q +++ G+ S +RF +K Q+
Sbjct: 264 LDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQ 322
Query: 421 WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG 480
W+W++T + + ++ + E+I+CT++ V + ++ P + L+
Sbjct: 323 WIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDK 382
Query: 481 SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH---SKPLEKSDGLFAQD 537
L PRQ ++ G GL + +HS ++ H S+P L A+
Sbjct: 383 GSSLEPRQHFNTLDV----GASGL-NTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEA 437
Query: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQL----FSQGNTFP-PTPRPAENFRNSGLAP 592
P S+T+P Q+L SQ T P P P P+ L P
Sbjct: 438 STPALPR--------------SATLP--QELPVPGLSQAATMPAPLPSPSSCDLTQQLLP 481
Query: 593 PVTIVQPSASAGQMLAQIS 611
+ A Q AQ S
Sbjct: 482 QTVLQSTPAPMAQFSAQFS 500
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 133 bits (335), Expect = 5e-31
Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 46/387 (11%)
Query: 60 LRCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRM 119
+ D ++ + ER +E + R RR+K T EL+ +P +++ DK +I+R+
Sbjct: 1 MTADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRL 59
Query: 120 AVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVT 179
A+S +++ + + ++ + DQ++ +L L+A +GF+ +V+ + G ++++S++++
Sbjct: 60 AISFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENIS 116
Query: 180 PVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMR 239
+ Q E G +++D HP D +++RE LS + G KK
Sbjct: 117 KFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS----------GFGKKSKD----- 161
Query: 240 MCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKA 299
M + R F RM+C V NR R +V + V+HCTG +K
Sbjct: 162 --MSTERDFFMRMKCT--------------VTNRGR----TVNLKSATWKVLHCTGQVKV 201
Query: 300 WPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359
+ + P + G I + P+ D+ F+SRH+++ FT
Sbjct: 202 YN----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIP--LDSKTFLSRHSMDMKFT 255
Query: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
+ D R +GY P+ELLG++ EF H D + + S Q + KGQV+S +R +K+
Sbjct: 256 YCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHG 314
Query: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446
++W+ T NP + + + I+C N
Sbjct: 315 GYVWLETQGTVIYNPRNLQPQCIMCVN 341
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 130 bits (326), Expect = 6e-30
Identities = 114/451 (25%), Positives = 208/451 (46%), Gaps = 61/451 (13%)
Query: 69 NDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLR 128
+DK++ R + ++ E++RR++ I EL M+P ARK DK T+L+ ++ ++ +
Sbjct: 29 DDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHK 85
Query: 129 GTGNTSTDGS-----YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 183
+D S +KP+FL+++E L+LEA DGF F+ G ++YVS+SVT +L
Sbjct: 86 EI-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGF-FLAIMTDGSIIYVSESVTSLLE 143
Query: 184 QPQSEWFGSTLYDQVHPDDVDKLREQLST---SENALTGRILDLKTGTVKKEGQQSSMRM 240
S+ ++++ + + ++ + LST ++LT L K
Sbjct: 144 HLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSK--------------- 188
Query: 241 CMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 300
++ F C M G+ +DP + +V+ +G+ K H G+
Sbjct: 189 ---NQLEFCCHMLRGT--IDPKEPSTYEYVKF-----IGNFKSLNSVSSSAH-NGF---- 233
Query: 301 PPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFT 359
G P + C VA RL +M V +P E F SRH++E F
Sbjct: 234 --EGTIQRTHRPS--YEDRVCFVATVRLATPQF--IKEMCTVEEPNEEFTSRHSLEWKFL 287
Query: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
F+DHR +GY P E+LG + ++ H +D + L + +++ G+ S +RF +K Q
Sbjct: 288 FLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQY-GKGKSCYYRFLTKGQ 346
Query: 420 EWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEM 479
+W+W++T + + ++ E+I+CT+T V + +R +LG +LP
Sbjct: 347 QWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAE-------RRRELGIEESLPETA 399
Query: 480 GSGQLAPRQQQQQTELDMVPGRDGLASYNHS 510
+ ++ V ++ L ++HS
Sbjct: 400 AD---KSQDSGSDNRINTVSLKEALERFDHS 427
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 129 bits (323), Expect = 1e-29
Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 62/387 (16%)
Query: 68 SNDKERFARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 123
+NDK++ + E E R RR+K + EL+ +P ++ DK +++R+ +S+
Sbjct: 7 ANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY 66
Query: 124 MK--SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181
++ L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V
Sbjct: 67 LRVRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKY 119
Query: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241
+ Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT---- 163
Query: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 164 ---QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY- 201
Query: 302 PAGVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359
+ P+ G + CLV I P+ +++ F+SRH+++ F+
Sbjct: 202 ----DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFS 253
Query: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
+ D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K
Sbjct: 254 YCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRG 312
Query: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446
++W+ T + N + + + I+C N
Sbjct: 313 GYVWVETQATVIYNTKNSQPQCIVCVN 339
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 129 bits (323), Expect = 1e-29
Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 62/387 (16%)
Query: 68 SNDKERFARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 123
+NDK++ + E E R RR+K + EL+ +P ++ DK +++R+ +S+
Sbjct: 7 ANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY 66
Query: 124 MK--SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181
++ L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V
Sbjct: 67 LRVRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKY 119
Query: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241
+ Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT---- 163
Query: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 164 ---QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY- 201
Query: 302 PAGVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359
+ P+ G + CLV I P+ +++ F+SRH+++ F+
Sbjct: 202 ----DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFS 253
Query: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
+ D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K
Sbjct: 254 YCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRG 312
Query: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446
++W+ T + N + + + I+C N
Sbjct: 313 GYVWVETQATVIYNTKNSQPQCIVCVN 339
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 110 bits (276), Expect = 4e-24
Identities = 87/381 (22%), Positives = 172/381 (45%), Gaps = 48/381 (12%)
Query: 66 QMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 125
Q + +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++
Sbjct: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Query: 126 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 66 MHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLS 120
Query: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 121 QLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------E 161
Query: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 162 RCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQ 203
Query: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D R
Sbjct: 204 TSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRI 258
Query: 366 VATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 425
GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +
Sbjct: 259 AEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQ 317
Query: 426 TSSFTFQNPYSDEIEYIICTN 446
T + + E I+C +
Sbjct: 318 TQATVVSGGRGPQSESIVCVH 338
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 110 bits (274), Expect = 6e-24
Identities = 86/371 (23%), Positives = 170/371 (45%), Gaps = 48/371 (12%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 135
+E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++ R
Sbjct: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHR----LCA 69
Query: 136 DGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLY 195
G + + L L+A +GF+ +++ E G + Y+S++V+ L Q E G +++
Sbjct: 70 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 128
Query: 196 DQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCG 255
D +HP D ++L++ L T + L+ R ++ T R F RM+
Sbjct: 129 DFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------ERCFSLRMKST 169
Query: 256 SSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAG 315
+S R R N + + V++C+G+++A+ P + P P++
Sbjct: 170 LTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQTSPAGSPDSE 211
Query: 316 QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQE 375
+ CLV I + P+ + F+SRH+++ FT+ D R GY P +
Sbjct: 212 PPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDD 266
Query: 376 LLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPY 435
L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +T +
Sbjct: 267 LIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQTQATVVSGGR 325
Query: 436 SDEIEYIICTN 446
+ E I+C +
Sbjct: 326 GPQSESIVCVH 336
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 106 bits (264), Expect = 9e-23
Identities = 94/376 (25%), Positives = 164/376 (43%), Gaps = 53/376 (14%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 131
+E R RR K + EL+ ++P SA+ + DK +I+R+ S++K G G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 132 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
S P +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
Query: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 250
G+++Y+ +HP D D++ L+ + + + + + RSF
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162
Query: 251 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDD 310
RM+C + + G G + V+HC+GY+K SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKI---RQYSL-DM 198
Query: 311 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVG 370
P G LVA+G S P F+ R +++ F+D R G
Sbjct: 199 SPFDGCYQNVGLVAVGH----SLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTG 254
Query: 371 YQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFT 430
Y+PQ+L+ K + H D LR + ++ +KGQV + +RF +K+ W+W+++ +
Sbjct: 255 YEPQDLIEKTLYHHVHGCDTFHLRCA-HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATI 313
Query: 431 FQNPYSDEIEYIICTN 446
N S I+ N
Sbjct: 314 VHNSRSSRPHCIVSVN 329
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 101 bits (251), Expect = 3e-21
Identities = 143/622 (22%), Positives = 245/622 (39%), Gaps = 99/622 (15%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 135
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 136 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 250
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
Query: 251 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 309
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
Query: 310 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 368
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 369 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 428
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 429 FTFQNPYSD-------------EIEY----IICTNTNVKNSSQEPRPTLSNTIQRPQLGP 471
N S EIEY + + S R LS + + +L
Sbjct: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK 371
Query: 472 TANLPLEMG-SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKP-LEK 529
N ++ P QQ ++D + + + P + P +P E
Sbjct: 372 PKNTKMKTKLRTNPYPPQQYSSFQMDKLE----CGQLGNWRASPPASAAAPPELQPHSES 427
Query: 530 SDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFP-------PTPRPA 582
SD L+ FS YH + + SS P F Q P + PA
Sbjct: 428 SDLLYTPSYSLPFS--YHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPA 485
Query: 583 ENFRNSGLAPPV--TIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQ 640
A P+ + P+ + + A +RHS P++ SG +V
Sbjct: 486 SGECQWHYANPLVPSSSSPAKNPPEPPANTARHS-----LVPSY--EGGSGLLVGKVGGL 538
Query: 641 ATAKTRTSQFGVGSFQT-PSSF 661
TA +R+S G +T PS F
Sbjct: 539 RTAGSRSSHGGGWQMETEPSRF 560
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 100 bits (250), Expect = 4e-21
Identities = 92/378 (24%), Positives = 165/378 (43%), Gaps = 57/378 (15%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 135
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 136 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 250
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
Query: 251 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 309
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
Query: 310 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 368
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
Query: 369 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 428
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
Query: 429 FTFQNPYSDEIEYIICTN 446
N S I+ N
Sbjct: 312 TVVHNSRSSRPHCIVSVN 329
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 97.4 bits (241), Expect = 4e-20
Identities = 105/405 (25%), Positives = 180/405 (44%), Gaps = 39/405 (9%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
Query: 126 --SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADGFLFIVSCETGRVVY 173
+LR G NTS G+ + PS L + + HL IL++ DGF+F ++ E G+ +Y
Sbjct: 83 PWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQE-GKFLY 141
Query: 174 VSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEG 233
+S++V+ L Q E GS+++D VHP D ++ EQL GR L L GT E
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM--KLPPGRGL-LSQGTA--ED 196
Query: 234 QQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHC 293
SS S S ++ R F+R + V + V+H
Sbjct: 197 GASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHI 256
Query: 294 TGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHN 353
TG ++ VSL Q +VA P ++ C F++R N
Sbjct: 257 TGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPPTINEVRIDCH--MFVTRVN 306
Query: 354 IEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFR 413
++ + ++R + P +++GK F H ED + +R S ++ KGQ ++ +R
Sbjct: 307 MDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYR 365
Query: 414 FRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRP 458
+ KN ++W+++S+ N + + II N + N + P
Sbjct: 366 WMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTP 410
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 93.2 bits (230), Expect = 8e-19
Identities = 76/330 (23%), Positives = 149/330 (45%), Gaps = 48/330 (14%)
Query: 117 LRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSD 176
+R+ +S+++ R G + + L L+A +GF+ +++ E G + Y+S+
Sbjct: 1 MRLTISYLRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSE 55
Query: 177 SVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS 236
+V+ L Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 56 NVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT---------- 104
Query: 237 SMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGY 296
R F RM+ +S R R N + + V++C+G+
Sbjct: 105 --------ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGH 138
Query: 297 IKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEG 356
++A+ P + P P++ + CLV I + P+ + F+SRH+++
Sbjct: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDM 193
Query: 357 IFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRS 416
FT+ D R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +
Sbjct: 194 KFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLA 252
Query: 417 KNQEWLWMRTSSFTFQNPYSDEIEYIICTN 446
++ +LW +T + + E I+C +
Sbjct: 253 RSGGYLWTQTQATVVSGGRGPQSESIVCVH 282
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 88.2 bits (217), Expect = 3e-17
Identities = 105/424 (24%), Positives = 178/424 (41%), Gaps = 58/424 (13%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
Query: 126 --SLRGTG---NTSTDGSY----------------------KPSFLTDQELK-HL---IL 154
+LR G NTS G PS L + + HL IL
Sbjct: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
Query: 155 EAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSE 214
++ DGF+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP D ++ EQL
Sbjct: 143 QSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM-- 199
Query: 215 NALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRC 274
GR L L GT E SS S S ++ R F+R +
Sbjct: 200 KLPPGRGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
Query: 275 RNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSP 334
V + V+H TG ++ VSL Q +VA P
Sbjct: 257 TLTKRGVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPP 308
Query: 335 NCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLR 394
++ C F++R N++ + ++R + P +++GK F H ED + +R
Sbjct: 309 TINEVRIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIR 366
Query: 395 DSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQ 454
S ++ KGQ ++ +R+ KN ++W+++S+ N + + II N + N
Sbjct: 367 HSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEY 425
Query: 455 EPRP 458
+ P
Sbjct: 426 KDTP 429
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 76.6 bits (187), Expect = 8e-14
Identities = 96/427 (22%), Positives = 176/427 (41%), Gaps = 68/427 (15%)
Query: 83 ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 136
E+RRR + + YI EL++++ KPDK IL+ V ++ ++ G T ++
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 137 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 189
S + L L+L+A DGFLF+V+ G +V+VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152
Query: 190 FGSTLYDQVHPDD-VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSF 248
+++Y+ +H +D D L+ ++ N + + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNGV--------SWTNETQRQKS---------HTF 195
Query: 249 ICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLP 308
CRM + +N +R R + + C +S P
Sbjct: 196 NCRMLMKTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 309 DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 368
E G+ + C++ + R T T SN P FI+RH++ G +D + +
Sbjct: 233 RAMMEEGEDLQSCMICVARRITTGER--TFPSN---PESFITRHDLSGKVVNIDTNSLRS 287
Query: 369 VGYQP--QELLGKNIVEFCHPED-QQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 425
+P ++++ + I F D Q + Q L G + ++RF + + +
Sbjct: 288 -SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQ 346
Query: 426 TSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQL 484
T S F+NP +++ + T+ + + P P RP P A +G +
Sbjct: 347 TKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRP---PMAGCNSSVGGMSM 403
Query: 485 APRQQQQ 491
+P Q Q
Sbjct: 404 SPNQGLQ 410
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 76.6 bits (187), Expect = 8e-14
Identities = 96/427 (22%), Positives = 176/427 (41%), Gaps = 68/427 (15%)
Query: 83 ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 136
E+RRR + + YI EL++++ KPDK IL+ V ++ ++ G T ++
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 137 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 189
S + L L+L+A DGFLF+V+ G +V+VS++VT L Q +
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152
Query: 190 FGSTLYDQVHPDD-VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSF 248
+++Y+ +H +D D L+ ++ N + + T + + Q+S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNGV--------SWTNETQRQKS---------HTF 195
Query: 249 ICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLP 308
CRM + +N +R R + + C +S P
Sbjct: 196 NCRMLMKTPHDILEDINASPEMRQR--------------YETMQC---------FALSQP 232
Query: 309 DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 368
E G+ + C++ + R T T SN P FI+RH++ G +D + +
Sbjct: 233 RAMMEEGEDLQSCMICVARRITTGER--TFPSN---PESFITRHDLSGKVVNIDTNSLRS 287
Query: 369 VGYQP--QELLGKNIVEFCHPED-QQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 425
+P ++++ + I F D Q + Q L G + ++RF + + +
Sbjct: 288 -SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQ 346
Query: 426 TSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQL 484
T S F+NP +++ + T+ + + P P RP P A +G +
Sbjct: 347 TKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRP---PMAGCNSSVGGMSM 403
Query: 485 APRQQQQ 491
+P Q Q
Sbjct: 404 SPNQGLQ 410
>gi|194097341 period 1 [Homo sapiens]
Length = 1290
Score = 75.5 bits (184), Expect = 2e-13
Identities = 109/481 (22%), Positives = 178/481 (37%), Gaps = 86/481 (17%)
Query: 142 SFLTDQELKHLI----LEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQ 197
S T +EL+H+ L+ D F VS TGR+VY+S+ +L + + G+ +
Sbjct: 198 STYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSEL 257
Query: 198 VHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSS 257
+ P DV + S G TG G + + +S CR+R G
Sbjct: 258 LAPQDVGVFYGSTAPSRLPTWG------TGASAGSGLRDFTQ-----EKSVFCRIRGGPD 306
Query: 258 SVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQG 317
+D P + T Y+ + + D P
Sbjct: 307 ------------------------RDPGPRYQPFRLTPYVTK-----IRVSDGAP----A 333
Query: 318 SKFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQEL 376
CL+ R+ +P + F +RH +F VD R +GY PQ+L
Sbjct: 334 QPCCLLIAERIHSGYEAPRIPPDKRI-----FTTRHTPSCLFQDVDERAAPLLGYLPQDL 388
Query: 377 LGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLS-VMFRFRSKNQEWLWMRTSSFTFQNPY 435
LG ++ F HPED+ L+ +++++L GQ RF ++N E++ M TS F +P+
Sbjct: 389 LGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPW 448
Query: 436 SDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTEL 495
S ++ +++ P + P P +L ++ +L+ + + +
Sbjct: 449 SRKVAFVL------GRHKVRTAPLNEDVFTPPAPSPAPSLDTDI--QELSEQIHRLLLQP 500
Query: 496 DMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDP------RFSEIYHNI 549
P GL V VT+ GP HS P SD P F +I ++
Sbjct: 501 VHSPSPTGLCG------VGAVTSPGPLHS-PGSSSDSNGGDAEGPGPPAPVTFQQICKDV 553
Query: 550 NADQSKGISSSTVPATQQLFSQGNTFPPT-PRPAENFRNSGLAPPVTIVQPSASAGQMLA 608
+ + +G QQLF + P + PR A P P AG
Sbjct: 554 HLVKHQG---------QQLFIESRARPQSRPRLPATGTFKAKALPCQSPDPELEAGSAPV 604
Query: 609 Q 609
Q
Sbjct: 605 Q 605
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 80 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 132
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 133 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 366 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 422
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 423 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 482 G 482
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 485 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 537
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 597
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 598 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 648
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 649 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 702
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 703 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 759
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 2.9
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 469 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 526 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 576
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 577 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 636
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 637 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 686
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 80 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 132
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 133 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 366 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 422
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 423 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 482 G 482
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 485 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 537
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 597
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 598 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 648
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 649 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 702
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 703 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 759
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 2.9
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 469 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 526 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 576
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 577 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 636
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 637 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 686
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 80 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 132
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 133 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Q E +++Y +H D +N L +++ G +
Sbjct: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Query: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
+F CRM +P + N+ + R + V+ C V
Sbjct: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
Query: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
Query: 366 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 422
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
Query: 423 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
Query: 482 G 482
G
Sbjct: 399 G 399
Score = 36.2 bits (82), Expect = 0.12
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 485 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 537
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
Query: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 597
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
Query: 598 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 648
P G A P G P P + S FS +A+ R S
Sbjct: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
Query: 649 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 702
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 703 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 759
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
Score = 31.6 bits (70), Expect = 2.9
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 469 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
Query: 526 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 576
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
Query: 577 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 636
P P P PP + Q I ++ +Q TP ++
Sbjct: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
Query: 637 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 686
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 74.3 bits (181), Expect = 4e-13
Identities = 89/375 (23%), Positives = 160/375 (42%), Gaps = 63/375 (16%)
Query: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
Query: 126 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 177
LR G + G P+ L +Q L IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
Query: 178 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS- 236
V+ L Q E GS+++D +HP D ++ EQL L+T T S
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLG------------LRTPTPGPPTPPSV 213
Query: 237 SMRMCMGSRRSFICRMRCGSSSVDPVSV--NRLSFVRNR---CRNGLGSVKDGEPHFVVV 291
S S + + + V P S+ R FVR + + GL G + V+
Sbjct: 214 SSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASG---YKVI 270
Query: 292 HCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISR 351
H TG ++A V+L P A L G + + R
Sbjct: 271 HVTGRLRAHALGLVALGHTLPPAPLAE---LPLHGHM-------------------IVFR 308
Query: 352 HNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM 411
++ + R + P EL+G++ +F H +D +R S ++ KGQV++
Sbjct: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQVMTGY 367
Query: 412 FRFRSKNQEWLWMRT 426
+R+ + ++W+++
Sbjct: 368 YRWLQRAGGFVWLQS 382
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 69.3 bits (168), Expect = 1e-11
Identities = 89/427 (20%), Positives = 164/427 (38%), Gaps = 81/427 (18%)
Query: 46 GLDFDDDGEGNSKFLRCDDDQMSND--KERFARENH------------SEIERRRRNKMT 91
G D DD G+ + D + S D A+ H S+++ + ++
Sbjct: 55 GSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHK--ELI 112
Query: 92 AYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRG---------TGNTSTDGSYKPS 142
+ EL +P K L L+ A+ +K ++ + G+ PS
Sbjct: 113 KTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPS 172
Query: 143 FLTDQELKHL----ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQV 198
+ T +E++ + I++ AD F VS +G+++Y+SD V + + + + + + +
Sbjct: 173 Y-TVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFL 231
Query: 199 HPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSS 258
P DV S + L G S + CM +SF CR+ S
Sbjct: 232 APHDVGVFHSFTSPYKLPLWSMC----------SGADSFTQECM-EEKSFFCRVSVRKSH 280
Query: 259 VDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGS 318
+ + + P+ V V D + +
Sbjct: 281 ENEIRYHPFRMT---------------PYLVKVR------------------DQQGAESQ 307
Query: 319 KFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELL 377
CL+ R+ +P + F + H +F VD R V +GY PQ+L+
Sbjct: 308 LCCLLLAERVHSGYEAPRIPPEKRI-----FTTTHTPNCLFQDVDERAVPLLGYLPQDLI 362
Query: 378 GKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWMRTSSFTFQNPYS 436
++ HP D+ L+ +++++ GQ RFR++N E++ + TS +F NP+S
Sbjct: 363 ETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWS 422
Query: 437 DEIEYII 443
+I +II
Sbjct: 423 RKISFII 429
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 68.9 bits (167), Expect = 2e-11
Identities = 87/392 (22%), Positives = 158/392 (40%), Gaps = 73/392 (18%)
Query: 71 KERFARENHSEIERRRR--NKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLR 128
+ + A +HSE + R R ++ + E+ P S KP L L A+ + S++
Sbjct: 34 QRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFP--SERRNKPSTLDALNYALRCVHSVQ 91
Query: 129 GTGN----TSTDGSYKP--SFLTDQELKHLILEAA----DGFLFIVSCETGRVVYVSDSV 178
S +G+ + S + +EL + E D F+ + S +GR+V++S+
Sbjct: 92 ANSEFFQILSQNGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHISEQA 151
Query: 179 TPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSE----NALTGRILDLKTGTVKKEGQ 234
+LN+ + S D + P D+ + ++ N T R + VK
Sbjct: 152 ALILNRKKDVLASSHFVDLLAPQDMRVFYAHTARAQLPFWNNWTQRAARYECAPVKP--- 208
Query: 235 QSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCT 294
F CR+R G + +C + + P+ + VH
Sbjct: 209 -------------FFCRIRGGEDRK-----------QEKCHSPFRII----PYLIHVH-- 238
Query: 295 GYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVT-SSPNCTDMSNVCQPTEFISRHN 353
PA L + CL + ++ +P + F + H
Sbjct: 239 ------HPAQPEL--------ESEPCCLTVVEKIHSGYEAPRIPVNKRI-----FTTTHT 279
Query: 354 IEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQ--VLSVM 411
+F VD + V +GY PQ+L+G +I+ + HPED+ L+ Q+V+K G
Sbjct: 280 PGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSP 339
Query: 412 FRFRSKNQEWLWMRTSSFTFQNPYSDEIEYII 443
RF ++N +++ + +S +F NP+S +I +II
Sbjct: 340 IRFCTQNGDYIILDSSWSSFVNPWSRKISFII 371
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,803,515
Number of Sequences: 37866
Number of extensions: 1628194
Number of successful extensions: 5648
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 5143
Number of HSP's gapped (non-prelim): 586
length of query: 774
length of database: 18,247,518
effective HSP length: 110
effective length of query: 664
effective length of database: 14,082,258
effective search space: 9350619312
effective search space used: 9350619312
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.