Search of human proteins with 240255542

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
sapiens]
         (1036 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo ...  1998   0.0  
gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo ...  1936   0.0  
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s...  1910   0.0  
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s...  1910   0.0  
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ...  1292   0.0  
gi|156616290 collagen type VI alpha 6 [Homo sapiens]                  363   e-100
gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]              332   1e-90
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]        171   3e-42
gi|21359974 vitrin [Homo sapiens]                                     155   2e-37
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]             143   7e-34
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]        139   1e-32
gi|205277471 cochlin precursor [Homo sapiens]                         138   3e-32
gi|4758022 cochlin precursor [Homo sapiens]                           138   3e-32
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [...   132   2e-30
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]               129   1e-29
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                129   2e-29
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ...   119   1e-26
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]                111   4e-24
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa...   110   9e-24
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             107   4e-23
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             107   4e-23
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          99   2e-20
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]              96   2e-19
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]              96   2e-19
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]       93   1e-18
gi|11321565 matrilin 3 precursor [Homo sapiens]                        88   4e-17
gi|40068485 von Willebrand factor A domain containing 1 isoform ...    77   1e-13
gi|31657142 integrin, alpha 1 precursor [Homo sapiens]                 74   9e-13
gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens]        72   4e-12
gi|38569398 integrin, alpha 10 precursor [Homo sapiens]                69   3e-11

>gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
            sapiens]
          Length = 1036

 Score = 1998 bits (5177), Expect = 0.0
 Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60

Query: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120
            IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS
Sbjct: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120

Query: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180
            ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA
Sbjct: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180

Query: 181  DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGS 240
            DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGS
Sbjct: 181  DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGS 240

Query: 241  ANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLR 300
            ANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLR
Sbjct: 241  ANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLR 300

Query: 301  QLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALT 360
            QLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALT
Sbjct: 301  QLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALT 360

Query: 361  RAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV 420
            RAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV
Sbjct: 361  RAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV 420

Query: 421  PLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVE 480
            PLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVE
Sbjct: 421  PLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVE 480

Query: 481  SRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLL 540
            SRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLL
Sbjct: 481  SRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLL 540

Query: 541  VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHP 600
            VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHP
Sbjct: 541  VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHP 600

Query: 601  QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 660
            QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV
Sbjct: 601  QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 660

Query: 661  AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR 720
            AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR
Sbjct: 661  AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR 720

Query: 721  ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVA 780
            ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVA
Sbjct: 721  ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVA 780

Query: 781  IPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE 840
            IPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE
Sbjct: 781  IPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE 840

Query: 841  FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGG 900
            FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGG
Sbjct: 841  FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGG 900

Query: 901  RQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPF 960
            RQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPF
Sbjct: 901  RQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPF 960

Query: 961  TIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPP 1020
            TIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPP
Sbjct: 961  TIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPP 1020

Query: 1021 PGEMGASEVLLGAFSI 1036
            PGEMGASEVLLGAFSI
Sbjct: 1021 PGEMGASEVLLGAFSI 1036


>gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
            sapiens]
          Length = 1237

 Score = 1936 bits (5016), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 31   VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 90
            VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF
Sbjct: 232  VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 291

Query: 91   YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 150
            YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT
Sbjct: 292  YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 351

Query: 151  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 210
            GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML
Sbjct: 352  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 411

Query: 211  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 270
            PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR
Sbjct: 412  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 471

Query: 271  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 330
            VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS
Sbjct: 472  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 531

Query: 331  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 390
            RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY
Sbjct: 532  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 591

Query: 391  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 450
            LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD
Sbjct: 592  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 651

Query: 451  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 510
            FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG
Sbjct: 652  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 711

Query: 511  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 570
            YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN
Sbjct: 712  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 771

Query: 571  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 630
            ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS
Sbjct: 772  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 831

Query: 631  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 690
            EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ
Sbjct: 832  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 891

Query: 691  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 750
            LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR
Sbjct: 892  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 951

Query: 751  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 810
            GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ
Sbjct: 952  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1011

Query: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 870
            PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS
Sbjct: 1012 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 1071

Query: 871  DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 930
            DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP
Sbjct: 1072 DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 1131

Query: 931  QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 990
            QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL
Sbjct: 1132 QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 1191

Query: 991  PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1036
            PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI
Sbjct: 1192 PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1237



 Score =  695 bits (1794), Expect = 0.0
 Identities = 411/1052 (39%), Positives = 628/1052 (59%), Gaps = 45/1052 (4%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA  +    DI+FL+DGS+  G  NF  I DF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQD--SADIIFLIDGSNNTGSVNFAVILDF 58

Query: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120
            +  ++++L IG   I+V V Q++D  R  F  +T+ TK +V+ AV+ +    G     G 
Sbjct: 59   LVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGL 118

Query: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180
            ALDFV  N FT + G R  EG+P++LVLI+ G S DEI      LK++S+ +F +G + A
Sbjct: 119  ALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAA 178

Query: 181  DQAELEEIAFDSSLVFIPAEFRA-APLQ-GMLPGL---------LAPLRTLSGTPEVHSN 229
             +AEL+ IA D +LVF   EFR+   LQ  +LP +         L P   ++   EV  N
Sbjct: 179  SRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEV--N 236

Query: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 289
            KRDI+FL+DGS+ +G  NF  +RDF+  ++  L+IG D I+V + Q++DT   EF  NT+
Sbjct: 237  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296

Query: 290  QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349
             TK +++  +R+++   GS L TGSAL +V  N FT + G R  E +P+LL+L+T G+S 
Sbjct: 297  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356

Query: 350  DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP--ALPQQLIQ 407
            D   Q A  L R+ I+ F +G   A++AELE+IAF+ SLV++  +F + P   +   L+ 
Sbjct: 357  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLA 416

Query: 408  PLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ--FPVVRDFLYKIIDELNVKPEG 465
            PL T    G  EV      +KRDI+FL DGSAN VG+  FP VRDF+  +++ L++  + 
Sbjct: 417  PLRTL--SGTPEV----HSNKRDIIFLLDGSAN-VGKTNFPYVRDFVMNLVNSLDIGNDN 469

Query: 466  TRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSA 525
             R+ + Q+SD    E   + +Q+K +IL  +++++++ G  LN G AL Y     F ++ 
Sbjct: 470  IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 529

Query: 526  GSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAF 585
            GSRI + V Q L+LL AG+S D     A+ L ++G++ F   A  A+ AELEQI  +P+ 
Sbjct: 530  GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL 589

Query: 586  ILAAESLPKIGDLHPQIVNLLKSVHNGAPAPV-----SGEKDVVFLLDGSEGVRSGFPLL 640
            +   +    +  L  Q++  L +  +G    V       ++D++FL DGS  +   FP++
Sbjct: 590  VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVV 649

Query: 641  KEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPN 700
            ++F+ ++++ L+V  +  R+AV QYSD  + E   + + +K +++N V+++ +  G   N
Sbjct: 650  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 709

Query: 701  TGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGI 760
             G AL++  R I V SAGSRI +GV Q L++L A RS D V  P+  +K+ G VP     
Sbjct: 710  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 769

Query: 761  GNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPG 820
             NAD  E++ I   P F +A  +  ++G +   I           ++ L+ V    P+P 
Sbjct: 770  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQI-----------VNLLKSVHNGAPAP- 817

Query: 821  VGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN 880
            V G++DVVFL+DGS+     F  ++  ++R+V+ LDVG D  RVAV+Q+SD  + EF LN
Sbjct: 818  VSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877

Query: 881  AHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK 940
            ++ +K +V NAV++L   GG   N G ALE+V RNI     GSRI EGVPQ L+++++ +
Sbjct: 878  SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937

Query: 941  SDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 999
            S D+V +P+V +K+ G  P  I   NAD  E+  IS  P++  ++ TFR+L +++Q +  
Sbjct: 938  SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISE 997

Query: 1000 PITTLTSEQIQKLLASTR-YPPPGEMGASEVL 1030
             +T LT E++ +L    +  P PG  G  +V+
Sbjct: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVV 1029


>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
            sapiens]
          Length = 2971

 Score = 1910 bits (4947), Expect = 0.0
 Identities = 993/1001 (99%), Positives = 997/1001 (99%), Gaps = 1/1001 (0%)

Query: 31   VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 90
            VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF
Sbjct: 232  VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 291

Query: 91   YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 150
            YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT
Sbjct: 292  YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 351

Query: 151  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 210
            GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML
Sbjct: 352  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 411

Query: 211  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 270
            PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR
Sbjct: 412  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 471

Query: 271  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 330
            VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS
Sbjct: 472  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 531

Query: 331  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 390
            RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY
Sbjct: 532  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 591

Query: 391  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 450
            LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD
Sbjct: 592  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 651

Query: 451  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 510
            FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG
Sbjct: 652  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 711

Query: 511  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 570
            YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN
Sbjct: 712  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 771

Query: 571  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 630
            ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS
Sbjct: 772  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 831

Query: 631  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 690
            EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ
Sbjct: 832  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 891

Query: 691  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 750
            LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR
Sbjct: 892  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 951

Query: 751  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 810
            GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ
Sbjct: 952  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1011

Query: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 870
            PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS
Sbjct: 1012 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 1071

Query: 871  DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 930
            DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP
Sbjct: 1072 DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 1131

Query: 931  QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 990
            QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL
Sbjct: 1132 QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 1191

Query: 991  PSLEQKLLTPITTLTSEQIQKLLASTRYPPPG-EMGASEVL 1030
            PSLEQKLLTPITTLTSEQIQKLLASTRYPPP  E  A++++
Sbjct: 1192 PSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIV 1232



 Score =  695 bits (1794), Expect = 0.0
 Identities = 411/1052 (39%), Positives = 628/1052 (59%), Gaps = 45/1052 (4%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA  +    DI+FL+DGS+  G  NF  I DF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQD--SADIIFLIDGSNNTGSVNFAVILDF 58

Query: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120
            +  ++++L IG   I+V V Q++D  R  F  +T+ TK +V+ AV+ +    G     G 
Sbjct: 59   LVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGL 118

Query: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180
            ALDFV  N FT + G R  EG+P++LVLI+ G S DEI      LK++S+ +F +G + A
Sbjct: 119  ALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAA 178

Query: 181  DQAELEEIAFDSSLVFIPAEFRA-APLQ-GMLPGL---------LAPLRTLSGTPEVHSN 229
             +AEL+ IA D +LVF   EFR+   LQ  +LP +         L P   ++   EV  N
Sbjct: 179  SRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEV--N 236

Query: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 289
            KRDI+FL+DGS+ +G  NF  +RDF+  ++  L+IG D I+V + Q++DT   EF  NT+
Sbjct: 237  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296

Query: 290  QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349
             TK +++  +R+++   GS L TGSAL +V  N FT + G R  E +P+LL+L+T G+S 
Sbjct: 297  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356

Query: 350  DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP--ALPQQLIQ 407
            D   Q A  L R+ I+ F +G   A++AELE+IAF+ SLV++  +F + P   +   L+ 
Sbjct: 357  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLA 416

Query: 408  PLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ--FPVVRDFLYKIIDELNVKPEG 465
            PL T    G  EV      +KRDI+FL DGSAN VG+  FP VRDF+  +++ L++  + 
Sbjct: 417  PLRTL--SGTPEV----HSNKRDIIFLLDGSAN-VGKTNFPYVRDFVMNLVNSLDIGNDN 469

Query: 466  TRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSA 525
             R+ + Q+SD    E   + +Q+K +IL  +++++++ G  LN G AL Y     F ++ 
Sbjct: 470  IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 529

Query: 526  GSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAF 585
            GSRI + V Q L+LL AG+S D     A+ L ++G++ F   A  A+ AELEQI  +P+ 
Sbjct: 530  GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL 589

Query: 586  ILAAESLPKIGDLHPQIVNLLKSVHNGAPAPV-----SGEKDVVFLLDGSEGVRSGFPLL 640
            +   +    +  L  Q++  L +  +G    V       ++D++FL DGS  +   FP++
Sbjct: 590  VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVV 649

Query: 641  KEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPN 700
            ++F+ ++++ L+V  +  R+AV QYSD  + E   + + +K +++N V+++ +  G   N
Sbjct: 650  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 709

Query: 701  TGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGI 760
             G AL++  R I V SAGSRI +GV Q L++L A RS D V  P+  +K+ G VP     
Sbjct: 710  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 769

Query: 761  GNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPG 820
             NAD  E++ I   P F +A  +  ++G +   I           ++ L+ V    P+P 
Sbjct: 770  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQI-----------VNLLKSVHNGAPAP- 817

Query: 821  VGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN 880
            V G++DVVFL+DGS+     F  ++  ++R+V+ LDVG D  RVAV+Q+SD  + EF LN
Sbjct: 818  VSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877

Query: 881  AHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK 940
            ++ +K +V NAV++L   GG   N G ALE+V RNI     GSRI EGVPQ L+++++ +
Sbjct: 878  SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937

Query: 941  SDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 999
            S D+V +P+V +K+ G  P  I   NAD  E+  IS  P++  ++ TFR+L +++Q +  
Sbjct: 938  SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISE 997

Query: 1000 PITTLTSEQIQKLLASTR-YPPPGEMGASEVL 1030
             +T LT E++ +L    +  P PG  G  +V+
Sbjct: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVV 1029



 Score =  641 bits (1653), Expect = 0.0
 Identities = 384/989 (38%), Positives = 572/989 (57%), Gaps = 34/989 (3%)

Query: 35   NKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNT 94
            +KRDI+FL DGS+ L +  F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F+ 
Sbjct: 628  SKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDE 686

Query: 95   HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 154
            H +K E++  V++MK   G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G+S
Sbjct: 687  HQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS 746

Query: 155  LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLL 214
             D +  PA  LK+S ++ F    K AD AELE+I    S  FI A      +  + P ++
Sbjct: 747  SDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIV 804

Query: 215  APLRTL-SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 273
              L+++ +G P   S ++D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV +
Sbjct: 805  NLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAV 863

Query: 274  VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333
            VQ+SD    EF LN+Y  K D++  +RQL L GG   NTG+AL +V  N    + GSRI 
Sbjct: 864  VQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRIT 923

Query: 334  EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMD 393
            E VPQLL++LTA +S D     +  + R G +   +G   A+  E++ I+F P     + 
Sbjct: 924  EGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIP 983

Query: 394  DFSSLPALPQQLIQPLTTYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQFP 446
             F  L  + Q + + +T      +  + P+ QP        KRD++FL DGS +   +F 
Sbjct: 984  TFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQ 1043

Query: 447  VVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKA 506
             VR  + +++D L+V  + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G+ 
Sbjct: 1044 YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 1103

Query: 507  LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIF 566
            +N+G AL+Y  R IF +  GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF  
Sbjct: 1104 INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163

Query: 567  QAKNADPAELEQIVLSPAFILAAESLPKIGDLHP------------QIVNLLKSVHNGAP 614
             A+NAD  EL +I LSP ++ +  +  ++  L              QI  LL S     P
Sbjct: 1164 -ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP 1222

Query: 615  APVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEF 673
            A  S   D+VFL+D SEGVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   PEF
Sbjct: 1223 AVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEF 1282

Query: 674  YLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLT 733
            YL +Y ++  V++A+R+L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L+++ 
Sbjct: 1283 YLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVL 1342

Query: 734  ADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQV 793
              +S DDV   + V++  G V +G+G  N D TE+QTI+  P     +  FR+L  ++  
Sbjct: 1343 GGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE-- 1400

Query: 794  ISERVTQLTREELSRLQP--VLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIER 850
              ER+        +   P  V  P PS     K D+VFL+DGS       FQ V   +  
Sbjct: 1401 --ERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSE 1458

Query: 851  LVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALE 910
            +VD +    D+ +V ++Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    LE
Sbjct: 1459 IVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLE 1518

Query: 911  YVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQE 969
            ++  N F    GSR+++ VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D E
Sbjct: 1519 HLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSE 1578

Query: 970  ELVKISLSPEYVFSVSTFRELPSLEQKLL 998
            E+ KI+ +    F V   +EL  L +++L
Sbjct: 1579 EVGKIASNSATAFRVGNVQELSELSEQVL 1607



 Score =  458 bits (1178), Expect = e-128
 Identities = 282/836 (33%), Positives = 459/836 (54%), Gaps = 51/836 (6%)

Query: 36   KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
            ++D+VFL+DGS  +  + F  +++F+ +V++ L++GQD ++VAV QY+D  RPEFY N++
Sbjct: 821  EKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSY 879

Query: 96   PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
              K++V+ AVR++  L G    TG+AL+FV  N+  SSAG R  EG+P+LL+++T  +S 
Sbjct: 880  MNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSG 939

Query: 156  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL-VFIPAEFRAAPLQGMLP--- 211
            D++  P+  +KR   +   IG   AD  E++ I+F     V IP   +   +Q ++    
Sbjct: 940  DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERV 999

Query: 212  --------GLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                      L P+     +P V   KRD++FL+DGS + G   F YVR  +  LV+ LD
Sbjct: 1000 TQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLD 1057

Query: 264  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
            +G D  RV ++QFSD P  EF LN + +K ++   +++L+ +GG  +N G+AL YV  N 
Sbjct: 1058 VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNI 1117

Query: 324  FTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
            F    GSRI E VPQ L+L+++G+S+D     A  L + G+  F + A  A++ EL +I+
Sbjct: 1118 FKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKIS 1176

Query: 384  FNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV-------PLAQPESKRDILFLFD 436
             +P  V+ +  F  LP+L Q+L+ P+TT  S  ++++       P A      DI+FL D
Sbjct: 1177 LSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLID 1236

Query: 437  GSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNL 495
             S  +    F  +RDF+ +I+  LN+ P   R+ V Q+S+DV  E     ++S+  +L+ 
Sbjct: 1237 SSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDA 1296

Query: 496  VKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASN 555
            ++R++++ G  LN G AL++  R +FVKSAGSRIEDGV Q LVL++ G+S D V   A  
Sbjct: 1297 IRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQV 1356

Query: 556  LKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLL-KSVHNGAP 614
            ++ SG+V      +N D  EL+ I   P  +       ++ ++  +I+N    S    AP
Sbjct: 1357 IRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNSFGPSAATPAP 1416

Query: 615  A---------PVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQ 664
                      P   + D+VFLLDGS   R   F  +  FV  +V+++    D ++V +VQ
Sbjct: 1417 PGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQ 1476

Query: 665  YSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEG 724
            Y+     EF+L  +  K+ +++A+ ++   GG   NT   LE +  N  V  AGSR+ + 
Sbjct: 1477 YNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQR 1536

Query: 725  VPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTF 784
            VPQ+  V+T  +S +D ++ S+ + + G     +G+ N D  E+  I      A    T 
Sbjct: 1537 VPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI------ASNSATA 1590

Query: 785  RQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-----GGKRDVVFLIDGSQ 835
             ++G VQ+     +++L+ + L  L   +     PGV         DV+   DGS+
Sbjct: 1591 FRVGNVQE-----LSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSR 1641



 Score =  258 bits (660), Expect = 2e-68
 Identities = 186/620 (30%), Positives = 302/620 (48%), Gaps = 39/620 (6%)

Query: 32   IEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFY 91
            +E +  DIVFL+D S  +    F  IRDF++++++RL IG   ++V V Q+++ V PEFY
Sbjct: 1224 VESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFY 1283

Query: 92   FNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITG 151
              T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  SAG R  +G+P+ LVL+ G
Sbjct: 1284 LKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLG 1343

Query: 152  GKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAP------ 205
            GKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D  LVF   EFR  P      
Sbjct: 1344 GKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERI 1403

Query: 206  LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSL 262
            +    P    P      TP        K DI+FLLDGS N  + +F  V  FV  +V+++
Sbjct: 1404 MNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTV 1463

Query: 263  DIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYAN 322
                D+I+VGLVQ++  P  EF L  + TK  I+  + ++  +GG   NT   L ++  N
Sbjct: 1464 YEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVN 1523

Query: 323  HFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
            HF    GSR+ + VPQ+  ++T G+S +     + ALT+ G+  F VG    +  E+ +I
Sbjct: 1524 HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI 1583

Query: 383  AFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPLAQPESKRDILFLFDGSANL 441
            A N +  + + +   L  L +Q+++ L   +   +   V  A      D++  FDGS + 
Sbjct: 1584 ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSRD- 1642

Query: 442  VGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAVAQYSDDVKVESRFDEHQSK 489
               F   + F  K+   LN       V   G      R++V   +    VE+ FD  + +
Sbjct: 1643 QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEA-FDFDEYQ 1701

Query: 490  PEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRV 549
            PE+L   + M+ +        Y L      +++        D V + ++    G   D  
Sbjct: 1702 PEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSPDSV-KVVIHFTDGADGDLA 1754

Query: 550  D--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI----LAAESLPKIGDLHPQ 601
            D    + NL+Q GV   I     +  +   L  +     F+    L    L    +L  Q
Sbjct: 1755 DLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQ 1814

Query: 602  IVNLLKSVHNGAPAPVSGEK 621
            + N+ +    G P   SG++
Sbjct: 1815 LDNIAEKACCGVPCKCSGQR 1834



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 421  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 475
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 2187 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 2246

Query: 476  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 534
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 2247 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 2301

Query: 535  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 590
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 2302 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 2360

Query: 591  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 629
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 2361 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2420

Query: 630  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 672
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2421 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2480

Query: 673  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 731
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2481 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2539

Query: 732  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 776
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2540 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2585



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 287
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 288  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 346
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 2314

Query: 347  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 393
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 2315 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 2374

Query: 394  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 450
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 2375 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2434

Query: 451  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 494
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2435 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2494

Query: 495  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 543
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2495 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2539



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 36/145 (24%), Positives = 73/145 (50%), Gaps = 22/145 (15%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT------ 85
            D+ F++D +    L  FN ++ +IA ++++L++  D        +VAV Q+A +      
Sbjct: 2413 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2472

Query: 86   ----VRPEFYFNTHPTKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 140
                V+ EF    + +K +++  + R M  L G+    GSA+++   N+F S+   R   
Sbjct: 2473 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL- 2530

Query: 141  GIPKLLVLITGGKSLDEISQPAQEL 165
               K++VL+  G+  ++  + AQ +
Sbjct: 2531 ---KIVVLMLTGEVPEQQLEEAQRV 2552



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 93
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 94   THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 149
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 2310

Query: 150  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 204
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 2311 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 2366

Query: 205  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 245
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 2367 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2426

Query: 246  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 289
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2427 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2486

Query: 290  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 347
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2487 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2541

Query: 348  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 401
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2542 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2601

Query: 402  P 402
            P
Sbjct: 2602 P 2602



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 826  DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 880
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 881  AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 939
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 2314

Query: 940  KSDDEVDDPAVELKQFGVAPFTIARNADQE 969
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 2315 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 2344


>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
            sapiens]
          Length = 3177

 Score = 1910 bits (4947), Expect = 0.0
 Identities = 993/1001 (99%), Positives = 997/1001 (99%), Gaps = 1/1001 (0%)

Query: 31   VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 90
            VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF
Sbjct: 438  VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 497

Query: 91   YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 150
            YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT
Sbjct: 498  YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 557

Query: 151  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 210
            GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML
Sbjct: 558  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 617

Query: 211  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 270
            PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR
Sbjct: 618  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 677

Query: 271  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 330
            VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS
Sbjct: 678  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 737

Query: 331  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 390
            RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY
Sbjct: 738  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 797

Query: 391  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 450
            LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD
Sbjct: 798  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 857

Query: 451  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 510
            FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG
Sbjct: 858  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 917

Query: 511  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 570
            YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN
Sbjct: 918  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 977

Query: 571  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 630
            ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS
Sbjct: 978  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 1037

Query: 631  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 690
            EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ
Sbjct: 1038 EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 1097

Query: 691  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 750
            LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR
Sbjct: 1098 LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 1157

Query: 751  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 810
            GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ
Sbjct: 1158 GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1217

Query: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 870
            PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS
Sbjct: 1218 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 1277

Query: 871  DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 930
            DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP
Sbjct: 1278 DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 1337

Query: 931  QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 990
            QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL
Sbjct: 1338 QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 1397

Query: 991  PSLEQKLLTPITTLTSEQIQKLLASTRYPPPG-EMGASEVL 1030
            PSLEQKLLTPITTLTSEQIQKLLASTRYPPP  E  A++++
Sbjct: 1398 PSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIV 1438



 Score =  699 bits (1805), Expect = 0.0
 Identities = 404/1024 (39%), Positives = 610/1024 (59%), Gaps = 40/1024 (3%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKR-DIVFLVDGSSALGLANFNAIRD 59
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA ++     DI+FLVD S  +G  +F  +R+
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60

Query: 60   FIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTG 119
            F+  V++ L +G++    A+ Q+      EF  NT+ TK+EV++ +  M  + G+   TG
Sbjct: 61   FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISNMSYIGGTN-QTG 119

Query: 120  SALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKG 179
              L+++  +  T +AG RA +G+P+++V++T G S D ++ P+ ELK + +  FAIG + 
Sbjct: 120  KGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVED 179

Query: 180  ADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPE-----------VHS 228
            AD+  L+EIA +   + +        L  ++  L++ + + S +PE              
Sbjct: 180  ADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHS-SVSPERAGDTETLKDITAQ 238

Query: 229  NKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNT 288
            +  DIIFL+DGS N G  NF  + DF++NL+  L IG   IRVG+VQFSD P T FSL+T
Sbjct: 239  DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 298

Query: 289  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 348
            Y TK+ +LG ++ L   GG   N G AL +V  NHFT AGGSR+ E VPQ+L+L++AG S
Sbjct: 299  YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 358

Query: 349  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQP 408
             D       AL +A + +F +GA  A++AEL+ IA + +LV+ + +F S   L ++L+  
Sbjct: 359  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLL-- 416

Query: 409  LTTYVSGGVEEVPLAQPE---------SKRDILFLFDGSANL-VGQFPVVRDFLYKIIDE 458
               Y+ G  +   + +P          +KRDI+FL DGS+ L +  F  +RDF+ K+I  
Sbjct: 417  --PYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 474

Query: 459  LNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQR 518
            L +  +  ++AVAQY+D V+ E  F+ H +K E++  V++MK   G AL  G ALD+ + 
Sbjct: 475  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 534

Query: 519  YIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQ 578
             +F  SAG R  +G+ + LVL+  G+S D +  PA  LK+S ++ F    K AD AELE+
Sbjct: 535  NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 594

Query: 579  IVL--SPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RS 635
            I    S  FI A      +  + P ++  L+++ +G P   S ++D++FLLDGS  V ++
Sbjct: 595  IAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTL-SGTPEVHSNKRDIIFLLDGSANVGKT 653

Query: 636  GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLG 695
             FP +++FV  +V SLD+G D +RV +VQ+SD    EF LN+Y  K D++  +RQL L G
Sbjct: 654  NFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQG 713

Query: 696  GPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVP 755
            G   NTG+AL +V  N    + GSRI E VPQLL++LTA +S D     +  + R G + 
Sbjct: 714  GSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILT 773

Query: 756  IGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQP 815
              +G   A+  E++ I+F P     +  F  L  + Q + + +T      +  + P+ QP
Sbjct: 774  FCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV-PLAQP 832

Query: 816  LPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKV 875
                    KRD++FL DGS +   +F  VR  + +++D L+V  + TR+AV Q+SDD KV
Sbjct: 833  ------ESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKV 886

Query: 876  EFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVL 935
            E   + H SK E+ N V+R++ K G+ +N+G AL+Y  R IF +  GSRIE+GV QFLVL
Sbjct: 887  ESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVL 946

Query: 936  ISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 994
            + +G+S D VD PA  LKQ GV PF   A+NAD  EL +I LSP ++ +  +  ++  L 
Sbjct: 947  LVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLH 1006

Query: 995  QKLL 998
             +++
Sbjct: 1007 PQIV 1010



 Score =  641 bits (1653), Expect = 0.0
 Identities = 384/989 (38%), Positives = 572/989 (57%), Gaps = 34/989 (3%)

Query: 35   NKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNT 94
            +KRDI+FL DGS+ L +  F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F+ 
Sbjct: 834  SKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDE 892

Query: 95   HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 154
            H +K E++  V++MK   G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G+S
Sbjct: 893  HQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS 952

Query: 155  LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLL 214
             D +  PA  LK+S ++ F    K AD AELE+I    S  FI A      +  + P ++
Sbjct: 953  SDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIV 1010

Query: 215  APLRTL-SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 273
              L+++ +G P   S ++D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV +
Sbjct: 1011 NLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAV 1069

Query: 274  VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333
            VQ+SD    EF LN+Y  K D++  +RQL L GG   NTG+AL +V  N    + GSRI 
Sbjct: 1070 VQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRIT 1129

Query: 334  EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMD 393
            E VPQLL++LTA +S D     +  + R G +   +G   A+  E++ I+F P     + 
Sbjct: 1130 EGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIP 1189

Query: 394  DFSSLPALPQQLIQPLTTYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQFP 446
             F  L  + Q + + +T      +  + P+ QP        KRD++FL DGS +   +F 
Sbjct: 1190 TFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQ 1249

Query: 447  VVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKA 506
             VR  + +++D L+V  + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G+ 
Sbjct: 1250 YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 1309

Query: 507  LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIF 566
            +N+G AL+Y  R IF +  GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF  
Sbjct: 1310 INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1369

Query: 567  QAKNADPAELEQIVLSPAFILAAESLPKIGDLHP------------QIVNLLKSVHNGAP 614
             A+NAD  EL +I LSP ++ +  +  ++  L              QI  LL S     P
Sbjct: 1370 -ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP 1428

Query: 615  APVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEF 673
            A  S   D+VFL+D SEGVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   PEF
Sbjct: 1429 AVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEF 1488

Query: 674  YLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLT 733
            YL +Y ++  V++A+R+L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L+++ 
Sbjct: 1489 YLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVL 1548

Query: 734  ADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQV 793
              +S DDV   + V++  G V +G+G  N D TE+QTI+  P     +  FR+L  ++  
Sbjct: 1549 GGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE-- 1606

Query: 794  ISERVTQLTREELSRLQP--VLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIER 850
              ER+        +   P  V  P PS     K D+VFL+DGS       FQ V   +  
Sbjct: 1607 --ERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSE 1664

Query: 851  LVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALE 910
            +VD +    D+ +V ++Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    LE
Sbjct: 1665 IVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLE 1724

Query: 911  YVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQE 969
            ++  N F    GSR+++ VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D E
Sbjct: 1725 HLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSE 1784

Query: 970  ELVKISLSPEYVFSVSTFRELPSLEQKLL 998
            E+ KI+ +    F V   +EL  L +++L
Sbjct: 1785 EVGKIASNSATAFRVGNVQELSELSEQVL 1813



 Score =  458 bits (1178), Expect = e-128
 Identities = 282/836 (33%), Positives = 459/836 (54%), Gaps = 51/836 (6%)

Query: 36   KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
            ++D+VFL+DGS  +  + F  +++F+ +V++ L++GQD ++VAV QY+D  RPEFY N++
Sbjct: 1027 EKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSY 1085

Query: 96   PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
              K++V+ AVR++  L G    TG+AL+FV  N+  SSAG R  EG+P+LL+++T  +S 
Sbjct: 1086 MNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSG 1145

Query: 156  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL-VFIPAEFRAAPLQGMLP--- 211
            D++  P+  +KR   +   IG   AD  E++ I+F     V IP   +   +Q ++    
Sbjct: 1146 DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERV 1205

Query: 212  --------GLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                      L P+     +P V   KRD++FL+DGS + G   F YVR  +  LV+ LD
Sbjct: 1206 TQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLD 1263

Query: 264  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
            +G D  RV ++QFSD P  EF LN + +K ++   +++L+ +GG  +N G+AL YV  N 
Sbjct: 1264 VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNI 1323

Query: 324  FTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
            F    GSRI E VPQ L+L+++G+S+D     A  L + G+  F + A  A++ EL +I+
Sbjct: 1324 FKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKIS 1382

Query: 384  FNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV-------PLAQPESKRDILFLFD 436
             +P  V+ +  F  LP+L Q+L+ P+TT  S  ++++       P A      DI+FL D
Sbjct: 1383 LSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLID 1442

Query: 437  GSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNL 495
             S  +    F  +RDF+ +I+  LN+ P   R+ V Q+S+DV  E     ++S+  +L+ 
Sbjct: 1443 SSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDA 1502

Query: 496  VKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASN 555
            ++R++++ G  LN G AL++  R +FVKSAGSRIEDGV Q LVL++ G+S D V   A  
Sbjct: 1503 IRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQV 1562

Query: 556  LKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLL-KSVHNGAP 614
            ++ SG+V      +N D  EL+ I   P  +       ++ ++  +I+N    S    AP
Sbjct: 1563 IRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNSFGPSAATPAP 1622

Query: 615  A---------PVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQ 664
                      P   + D+VFLLDGS   R   F  +  FV  +V+++    D ++V +VQ
Sbjct: 1623 PGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQ 1682

Query: 665  YSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEG 724
            Y+     EF+L  +  K+ +++A+ ++   GG   NT   LE +  N  V  AGSR+ + 
Sbjct: 1683 YNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQR 1742

Query: 725  VPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTF 784
            VPQ+  V+T  +S +D ++ S+ + + G     +G+ N D  E+  I      A    T 
Sbjct: 1743 VPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI------ASNSATA 1796

Query: 785  RQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-----GGKRDVVFLIDGSQ 835
             ++G VQ+     +++L+ + L  L   +     PGV         DV+   DGS+
Sbjct: 1797 FRVGNVQE-----LSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSR 1847



 Score =  258 bits (660), Expect = 2e-68
 Identities = 186/620 (30%), Positives = 302/620 (48%), Gaps = 39/620 (6%)

Query: 32   IEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFY 91
            +E +  DIVFL+D S  +    F  IRDF++++++RL IG   ++V V Q+++ V PEFY
Sbjct: 1430 VESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFY 1489

Query: 92   FNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITG 151
              T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  SAG R  +G+P+ LVL+ G
Sbjct: 1490 LKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLG 1549

Query: 152  GKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAP------ 205
            GKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D  LVF   EFR  P      
Sbjct: 1550 GKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERI 1609

Query: 206  LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSL 262
            +    P    P      TP        K DI+FLLDGS N  + +F  V  FV  +V+++
Sbjct: 1610 MNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTV 1669

Query: 263  DIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYAN 322
                D+I+VGLVQ++  P  EF L  + TK  I+  + ++  +GG   NT   L ++  N
Sbjct: 1670 YEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVN 1729

Query: 323  HFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
            HF    GSR+ + VPQ+  ++T G+S +     + ALT+ G+  F VG    +  E+ +I
Sbjct: 1730 HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI 1789

Query: 383  AFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPLAQPESKRDILFLFDGSANL 441
            A N +  + + +   L  L +Q+++ L   +   +   V  A      D++  FDGS + 
Sbjct: 1790 ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSRD- 1848

Query: 442  VGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAVAQYSDDVKVESRFDEHQSK 489
               F   + F  K+   LN       V   G      R++V   +    VE+ FD  + +
Sbjct: 1849 QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEA-FDFDEYQ 1907

Query: 490  PEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRV 549
            PE+L   + M+ +        Y L      +++        D V + ++    G   D  
Sbjct: 1908 PEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSPDSV-KVVIHFTDGADGDLA 1960

Query: 550  D--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI----LAAESLPKIGDLHPQ 601
            D    + NL+Q GV   I     +  +   L  +     F+    L    L    +L  Q
Sbjct: 1961 DLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQ 2020

Query: 602  IVNLLKSVHNGAPAPVSGEK 621
            + N+ +    G P   SG++
Sbjct: 2021 LDNIAEKACCGVPCKCSGQR 2040



 Score =  217 bits (553), Expect = 4e-56
 Identities = 141/404 (34%), Positives = 218/404 (53%), Gaps = 11/404 (2%)

Query: 609  VHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSD 667
            V NGA A      D++FL+D S  +    F L++EF+  VV+SL VG++    A+VQ++ 
Sbjct: 32   VKNGAAA------DIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNG 85

Query: 668  RTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQ 727
                EF LN+Y  KQ+V++ +  ++ +GG T  TG  LE+++++ L  +AGSR  +GVPQ
Sbjct: 86   NPHTEFLLNTYRTKQEVLSHISNMSYIGG-TNQTGKGLEYIMQSHLTKAAGSRAGDGVPQ 144

Query: 728  LLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQL 787
            +++VLT   S D +  PS  +K        IG+ +AD   ++ I+  P   + +      
Sbjct: 145  VIVVLTDGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIASEP-LNMHMFNLENF 203

Query: 788  GTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRT 846
             ++  ++   V+ +            + L         D++FLIDGS + G   F  +  
Sbjct: 204  TSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILD 263

Query: 847  LIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVG 906
             +  L++ L +G    RV V+QFSD+P+  F L+ +S+K +V  AV+ L   GG   N+G
Sbjct: 264  FLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIG 323

Query: 907  NALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARN 965
             AL++V  N F R  GSR+EEGVPQ LVLIS+G S DE+    V LKQ  V  F + A+ 
Sbjct: 324  LALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQA 383

Query: 966  ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQI 1009
            A + EL  I+     VF+V  FR    L++KLL  I  +    I
Sbjct: 384  ASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHI 427



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 421  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 475
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 2393 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 2452

Query: 476  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 534
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 2453 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 2507

Query: 535  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 590
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 2508 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 2566

Query: 591  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 629
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 2567 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2626

Query: 630  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 672
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2627 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2686

Query: 673  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 731
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2687 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2745

Query: 732  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 776
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2746 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2791



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 287
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 288  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 346
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 2520

Query: 347  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 393
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 2521 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 2580

Query: 394  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 450
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 2581 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2640

Query: 451  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 494
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2641 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2700

Query: 495  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 543
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2701 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2745



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 36/145 (24%), Positives = 73/145 (50%), Gaps = 22/145 (15%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT------ 85
            D+ F++D +    L  FN ++ +IA ++++L++  D        +VAV Q+A +      
Sbjct: 2619 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2678

Query: 86   ----VRPEFYFNTHPTKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 140
                V+ EF    + +K +++  + R M  L G+    GSA+++   N+F S+   R   
Sbjct: 2679 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL- 2736

Query: 141  GIPKLLVLITGGKSLDEISQPAQEL 165
               K++VL+  G+  ++  + AQ +
Sbjct: 2737 ---KIVVLMLTGEVPEQQLEEAQRV 2758



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 93
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 94   THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 149
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 2516

Query: 150  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 204
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 2517 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 2572

Query: 205  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 245
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 2573 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2632

Query: 246  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 289
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2633 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2692

Query: 290  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 347
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2693 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2747

Query: 348  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 401
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2748 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2807

Query: 402  P 402
            P
Sbjct: 2808 P 2808



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 826  DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 880
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 881  AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 939
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 2520

Query: 940  KSDDEVDDPAVELKQFGVAPFTIARNADQE 969
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 2521 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 2550


>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
            sapiens]
          Length = 2570

 Score = 1292 bits (3343), Expect = 0.0
 Identities = 685/823 (83%), Positives = 732/823 (88%), Gaps = 20/823 (2%)

Query: 220  LSGTPEVHS---------NKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 270
            LSG P  H+         NKRDI+FL+DGS+ +G  NF  +RDF+  ++  L+IG D I+
Sbjct: 17   LSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQ 76

Query: 271  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 330
            V + Q++DT   EF  NT+ TK +++  +R+++   GS L TGSAL +V  N FT + G 
Sbjct: 77   VAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGY 136

Query: 331  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 390
            R  E +P+LL+L+T G+S D   Q A  L R+ I+ F +G   A++AELE+IAF+ SLV+
Sbjct: 137  RAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVF 196

Query: 391  LMDDFSSLP--ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVV 448
            +  +F + P   +   L+ PL T +SG  EE       SKRDILFLFDGSANLVGQFPVV
Sbjct: 197  IPAEFRAAPLQGMLPGLLAPLRT-LSGTPEE-------SKRDILFLFDGSANLVGQFPVV 248

Query: 449  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 508
            RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN
Sbjct: 249  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 308

Query: 509  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 568
            LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA
Sbjct: 309  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 368

Query: 569  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD 628
            KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD
Sbjct: 369  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD 428

Query: 629  GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV 688
            GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV
Sbjct: 429  GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV 488

Query: 689  RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV 748
            RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV
Sbjct: 489  RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV 548

Query: 749  KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR 808
            KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR
Sbjct: 549  KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR 608

Query: 809  LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ 868
            LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ
Sbjct: 609  LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ 668

Query: 869  FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 928
            FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG
Sbjct: 669  FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 728

Query: 929  VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR 988
            VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR
Sbjct: 729  VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR 788

Query: 989  ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG-EMGASEVL 1030
            ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP  E  A++++
Sbjct: 789  ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIV 831



 Score =  940 bits (2430), Expect = 0.0
 Identities = 517/1013 (51%), Positives = 692/1013 (68%), Gaps = 25/1013 (2%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60

Query: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120
            IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS
Sbjct: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120

Query: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180
            ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA
Sbjct: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180

Query: 181  DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGS 240
            DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPE   +KRDI+FL DGS
Sbjct: 181  DQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPE--ESKRDILFLFDGS 238

Query: 241  AN-VGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHL 299
            AN VG+  FP VRDF+  +++ L++  +  R+ + Q+SD    E   + +Q+K +IL  +
Sbjct: 239  ANLVGQ--FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLV 296

Query: 300  RQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANAL 359
            ++++++ G  LN G AL Y     F ++ GSRI + V Q L+LL AG+S D     A+ L
Sbjct: 297  KRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNL 356

Query: 360  TRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEE 419
             ++G++ F   A  A+ AELEQI  +P+ +   +    +  L  Q++  L +  +G    
Sbjct: 357  KQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAP 416

Query: 420  VPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKV 479
            V       ++D++FL DGS  +   FP++++F+ ++++ L+V  +  R+AV QYSD  + 
Sbjct: 417  V-----SGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRP 471

Query: 480  ESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVL 539
            E   + + +K +++N V+++ +  G   N G AL++  R I V SAGSRI +GV Q L++
Sbjct: 472  EFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 531

Query: 540  LVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLH 599
            L A RS D V  P+  +K+ G VP      NAD  E++ I   P F +A  +  ++G + 
Sbjct: 532  LTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ 591

Query: 600  PQI-----------VNLLKSVHNGAPAP-VSGEKDVVFLLDGSEGVRSGFPLLKEFVQRV 647
              I           ++ L+ V    P+P V G++DVVFL+DGS+     F  ++  ++R+
Sbjct: 592  QVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERL 651

Query: 648  VESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEF 707
            V+ LDVG D  RVAV+Q+SD  + EF LN++ +K +V NAV++L   GG   N G ALE+
Sbjct: 652  VDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEY 711

Query: 708  VLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITE 767
            V RNI     GSRI EGVPQ L+++++ +S D+V +P+V +K+ G  P  I   NAD  E
Sbjct: 712  VSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEE 770

Query: 768  MQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDV 827
            +  IS  P++  ++ TFR+L +++Q +   +T LT E++ +L    +  P        D+
Sbjct: 771  LVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADI 830

Query: 828  VFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKD 886
            VFLID S+   P+ F ++R  + R+V  L++G    RV V+QFS+D   EF L  + S+ 
Sbjct: 831  VFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQA 890

Query: 887  EVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVD 946
             V +A++RLR +GG  +N G ALE+V+RN+F +  GSRIE+GVPQ LVL+  GKS D+V 
Sbjct: 891  PVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVS 950

Query: 947  DPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLL 998
              A  ++  G+    +  RN D+ EL  I+  P  VF+V  FRELP++E++++
Sbjct: 951  RFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIM 1003



 Score =  642 bits (1656), Expect = 0.0
 Identities = 385/991 (38%), Positives = 575/991 (58%), Gaps = 34/991 (3%)

Query: 33   EVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYF 92
            E +KRDI+FL DGS+ L +  F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F
Sbjct: 225  EESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRF 283

Query: 93   NTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGG 152
            + H +K E++  V++MK   G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G
Sbjct: 284  DEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 343

Query: 153  KSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPG 212
            +S D +  PA  LK+S ++ F    K AD AELE+I    S  FI A      +  + P 
Sbjct: 344  RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQ 401

Query: 213  LLAPLRTL-SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRV 271
            ++  L+++ +G P   S ++D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV
Sbjct: 402  IVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRV 460

Query: 272  GLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR 331
             +VQ+SD    EF LN+Y  K D++  +RQL L GG   NTG+AL +V  N    + GSR
Sbjct: 461  AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR 520

Query: 332  IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL 391
            I E VPQLL++LTA +S D     +  + R G +   +G   A+  E++ I+F P     
Sbjct: 521  ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVA 580

Query: 392  MDDFSSLPALPQQLIQPLTTYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQ 444
            +  F  L  + Q + + +T      +  + P+ QP        KRD++FL DGS +   +
Sbjct: 581  IPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE 640

Query: 445  FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTG 504
            F  VR  + +++D L+V  + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G
Sbjct: 641  FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGG 700

Query: 505  KALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPF 564
            + +N+G AL+Y  R IF +  GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF
Sbjct: 701  RQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPF 760

Query: 565  IFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHP------------QIVNLLKSVHNG 612
               A+NAD  EL +I LSP ++ +  +  ++  L              QI  LL S    
Sbjct: 761  TI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYP 819

Query: 613  APAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRP 671
             PA  S   D+VFL+D SEGVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   P
Sbjct: 820  PPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFP 879

Query: 672  EFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 731
            EFYL +Y ++  V++A+R+L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L++
Sbjct: 880  EFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVL 939

Query: 732  LTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ 791
            +   +S DDV   + V++  G V +G+G  N D TE+QTI+  P     +  FR+L  ++
Sbjct: 940  VLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE 999

Query: 792  QVISERVTQLTREELSRLQP--VLQPLPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLI 848
                ER+        +   P  V  P PS     K D+VFL+DGS +   + FQ V   +
Sbjct: 1000 ----ERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFV 1055

Query: 849  ERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNA 908
              +VD +    D+ +V ++Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    
Sbjct: 1056 SEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVG 1115

Query: 909  LEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNAD 967
            LE++  N F    GSR+++ VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D
Sbjct: 1116 LEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNID 1175

Query: 968  QEELVKISLSPEYVFSVSTFRELPSLEQKLL 998
             EE+ KI+ +    F V   +EL  L +++L
Sbjct: 1176 SEEVGKIASNSATAFRVGNVQELSELSEQVL 1206



 Score =  458 bits (1178), Expect = e-128
 Identities = 282/836 (33%), Positives = 459/836 (54%), Gaps = 51/836 (6%)

Query: 36   KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
            ++D+VFL+DGS  +  + F  +++F+ +V++ L++GQD ++VAV QY+D  RPEFY N++
Sbjct: 420  EKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSY 478

Query: 96   PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
              K++V+ AVR++  L G    TG+AL+FV  N+  SSAG R  EG+P+LL+++T  +S 
Sbjct: 479  MNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSG 538

Query: 156  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL-VFIPAEFRAAPLQGMLP--- 211
            D++  P+  +KR   +   IG   AD  E++ I+F     V IP   +   +Q ++    
Sbjct: 539  DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERV 598

Query: 212  --------GLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                      L P+     +P V   KRD++FL+DGS + G   F YVR  +  LV+ LD
Sbjct: 599  TQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLD 656

Query: 264  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
            +G D  RV ++QFSD P  EF LN + +K ++   +++L+ +GG  +N G+AL YV  N 
Sbjct: 657  VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNI 716

Query: 324  FTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
            F    GSRI E VPQ L+L+++G+S+D     A  L + G+  F + A  A++ EL +I+
Sbjct: 717  FKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKIS 775

Query: 384  FNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEV-------PLAQPESKRDILFLFD 436
             +P  V+ +  F  LP+L Q+L+ P+TT  S  ++++       P A      DI+FL D
Sbjct: 776  LSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLID 835

Query: 437  GSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNL 495
             S  +    F  +RDF+ +I+  LN+ P   R+ V Q+S+DV  E     ++S+  +L+ 
Sbjct: 836  SSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDA 895

Query: 496  VKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASN 555
            ++R++++ G  LN G AL++  R +FVKSAGSRIEDGV Q LVL++ G+S D V   A  
Sbjct: 896  IRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQV 955

Query: 556  LKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLL-KSVHNGAP 614
            ++ SG+V      +N D  EL+ I   P  +       ++ ++  +I+N    S    AP
Sbjct: 956  IRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNSFGPSAATPAP 1015

Query: 615  A---------PVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQ 664
                      P   + D+VFLLDGS   R   F  +  FV  +V+++    D ++V +VQ
Sbjct: 1016 PGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQ 1075

Query: 665  YSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEG 724
            Y+     EF+L  +  K+ +++A+ ++   GG   NT   LE +  N  V  AGSR+ + 
Sbjct: 1076 YNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQR 1135

Query: 725  VPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTF 784
            VPQ+  V+T  +S +D ++ S+ + + G     +G+ N D  E+  I      A    T 
Sbjct: 1136 VPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI------ASNSATA 1189

Query: 785  RQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-----GGKRDVVFLIDGSQ 835
             ++G VQ+     +++L+ + L  L   +     PGV         DV+   DGS+
Sbjct: 1190 FRVGNVQE-----LSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSR 1240



 Score =  258 bits (660), Expect = 2e-68
 Identities = 186/620 (30%), Positives = 302/620 (48%), Gaps = 39/620 (6%)

Query: 32   IEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFY 91
            +E +  DIVFL+D S  +    F  IRDF++++++RL IG   ++V V Q+++ V PEFY
Sbjct: 823  VESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFY 882

Query: 92   FNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITG 151
              T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  SAG R  +G+P+ LVL+ G
Sbjct: 883  LKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLG 942

Query: 152  GKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAP------ 205
            GKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D  LVF   EFR  P      
Sbjct: 943  GKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERI 1002

Query: 206  LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSL 262
            +    P    P      TP        K DI+FLLDGS N  + +F  V  FV  +V+++
Sbjct: 1003 MNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTV 1062

Query: 263  DIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYAN 322
                D+I+VGLVQ++  P  EF L  + TK  I+  + ++  +GG   NT   L ++  N
Sbjct: 1063 YEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVN 1122

Query: 323  HFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
            HF    GSR+ + VPQ+  ++T G+S +     + ALT+ G+  F VG    +  E+ +I
Sbjct: 1123 HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI 1182

Query: 383  AFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPLAQPESKRDILFLFDGSANL 441
            A N +  + + +   L  L +Q+++ L   +   +   V  A      D++  FDGS + 
Sbjct: 1183 ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSRD- 1241

Query: 442  VGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAVAQYSDDVKVESRFDEHQSK 489
               F   + F  K+   LN       V   G      R++V   +    VE+ FD  + +
Sbjct: 1242 QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEA-FDFDEYQ 1300

Query: 490  PEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRV 549
            PE+L   + M+ +        Y L      +++        D V + ++    G   D  
Sbjct: 1301 PEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSPDSV-KVVIHFTDGADGDLA 1353

Query: 550  D--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI----LAAESLPKIGDLHPQ 601
            D    + NL+Q GV   I     +  +   L  +     F+    L    L    +L  Q
Sbjct: 1354 DLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQ 1413

Query: 602  IVNLLKSVHNGAPAPVSGEK 621
            + N+ +    G P   SG++
Sbjct: 1414 LDNIAEKACCGVPCKCSGQR 1433



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 421  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 475
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 1786 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 1845

Query: 476  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 534
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 1846 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 1900

Query: 535  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 590
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 1901 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 1959

Query: 591  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 629
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 1960 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2019

Query: 630  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 672
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2020 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2079

Query: 673  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 731
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2080 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2138

Query: 732  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 776
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2139 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2184



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 287
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 288  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 346
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 1913

Query: 347  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 393
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 1914 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 1973

Query: 394  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 450
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 1974 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2033

Query: 451  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 494
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2034 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2093

Query: 495  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 543
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2094 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2138



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 36/145 (24%), Positives = 73/145 (50%), Gaps = 22/145 (15%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT------ 85
            D+ F++D +    L  FN ++ +IA ++++L++  D        +VAV Q+A +      
Sbjct: 2012 DMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNA 2071

Query: 86   ----VRPEFYFNTHPTKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 140
                V+ EF    + +K +++  + R M  L G+    GSA+++   N+F S+   R   
Sbjct: 2072 SMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL- 2129

Query: 141  GIPKLLVLITGGKSLDEISQPAQEL 165
               K++VL+  G+  ++  + AQ +
Sbjct: 2130 ---KIVVLMLTGEVPEQQLEEAQRV 2151



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 93
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 94   THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 149
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 1909

Query: 150  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 204
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 1910 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 1965

Query: 205  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 245
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 1966 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2025

Query: 246  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 289
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2026 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2085

Query: 290  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 347
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2086 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2140

Query: 348  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 401
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2141 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2200

Query: 402  P 402
            P
Sbjct: 2201 P 2201



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 826  DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 880
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 881  AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 939
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 1913

Query: 940  KSDDEVDDPAVELKQFGVAPFTIARNADQE 969
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 1914 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 1943


>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
          Length = 2263

 Score =  363 bits (932), Expect = e-100
 Identities = 271/990 (27%), Positives = 495/990 (50%), Gaps = 57/990 (5%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
            D+VFL+D S      NF+ ++ F+ + +  L+I ++ ++V +  Y++  +     +    
Sbjct: 229  DVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGIN 288

Query: 98   KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
            K EV+  ++ + P  G A YTG+A+  +R  +F++  G R  +G+P++ VL+T   S D 
Sbjct: 289  KSEVLQHIQNLSPRTGKA-YTGAAIKKLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDN 347

Query: 158  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPL 217
            +++ A  L+R  +  F +G +GA   +LE+IA   +  ++      A L       L  L
Sbjct: 348  VTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAAHNQTFLKKL 407

Query: 218  R-----TLSGTPE---------VHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
            R     T+S   E         V + + DI  L+DGS +   T+F  ++ F+  +V   +
Sbjct: 408  RNQITHTVSVFSERTETLKSGCVDTEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFN 467

Query: 264  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
            I    +RVG VQ++D+   EF +N Y  K D+   +  ++  GG+  NTG+AL++  +  
Sbjct: 468  IAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIENIRQMGGN-TNTGAALNFTLS-- 524

Query: 324  FTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
              +    +    VP  L++LT G S+DS L+ AN L    I  + +G  +AN+ +L +IA
Sbjct: 525  LLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQLREIA 584

Query: 384  FNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVG 443
                 VY + DF +L  +  Q++Q + T      EE   A  E K DI+FL D S ++  
Sbjct: 585  GEEKRVYYVHDFDALKDIRNQVVQEICT------EE---ACKEMKADIMFLVDSSGSIGP 635

Query: 444  Q-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIK 502
            + F  ++ F+  ++ +  + P+  +I V Q+SD  K E + +   S+ +I N + +M   
Sbjct: 636  ENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMSQSDISNAIDQM-AH 694

Query: 503  TGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVV 562
             G+    G AL +  +Y F  + G+R    + +FL+L+  G + D V  PA  L+Q GV+
Sbjct: 695  IGQTTLTGSALSFVSQY-FSPTKGAR--PNIRKFLILITDGEAQDIVKEPAVVLRQEGVI 751

Query: 563  PFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKD 622
             +      ++  +LE+I   P  +   E+   +  +   +V  + S             D
Sbjct: 752  IYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIEDDLVFGICSPREECKR--IEVLD 809

Query: 623  VVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNK 681
            VVF++D S  +    + ++K+F+  +V+  DVG+++VR   ++Y+D     FYL+ +  K
Sbjct: 810  VVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFGTK 869

Query: 682  QDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRS--GD 739
             +V++ ++    +GG T  T  AL F   ++   + GSR+ +GVPQ+LIV+T   S   D
Sbjct: 870  LEVISVLQNDQAMGGST-YTAEALGF-SDHMFTEARGSRLNKGVPQVLIVITDGESHDAD 927

Query: 740  DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVT 799
             +   +  ++  G + + +GI  A+  E+  ++   D    + TF  L  +   ++  V 
Sbjct: 928  KLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFVETFGGLKGIFSDVTASVC 987

Query: 800  QLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVG 858
              ++ +                  K D+VFL+DGS S  P +F+ ++  +  +V   DV 
Sbjct: 988  NSSKVDCEI--------------DKVDLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVS 1033

Query: 859  FDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFK 918
             +  R+   QFSD    EF L     + E+   ++ ++   G   ++G AL  V  + F+
Sbjct: 1034 LNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFG-NTHIGAALREV-EHYFR 1091

Query: 919  RPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLS 977
              +GSRI  G PQ L++++ G+S DEV   A  L+  G+  +++   + D ++L++I+ +
Sbjct: 1092 PDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGIGDVDDQQLIQITGT 1151

Query: 978  PEYVFSVSTFRELPSLEQKLLTPITTLTSE 1007
             E   +V  F EL  + ++++  I T   E
Sbjct: 1152 AEKKLTVHNFDELKKVNKRIVRNICTTAGE 1181



 Score =  351 bits (900), Expect = 2e-96
 Identities = 270/981 (27%), Positives = 486/981 (49%), Gaps = 54/981 (5%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VFLVD S  LG  +F  ++ FI K+I  L I  D  +VA+AQY+D +  EF+ +T   
Sbjct: 27  DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKG 86

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           +  ++  +RK     G +L  G AL       F++ A  R  +  P +LV++   +S D 
Sbjct: 87  RSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDN 146

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPL--QGMLPGLLA 215
           + + ++ L++  +   ++G + A +  L+ +A  S   F     R   +  Q M   +  
Sbjct: 147 VEEASKALRKDGVKIISVGVQKASEENLKAMA-TSQFHFNLRTVRDLSMFSQNMTHIIKD 205

Query: 216 PLRTLSGTPE-------VHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN 268
            ++   G  +          +  D++FLLD S N  + NF Y++ F+   V++LDI  + 
Sbjct: 206 VIKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENC 265

Query: 269 IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 328
           +RVGLV +S+      SL+    KS++L H++ L  + G    TG+A+  +    F+   
Sbjct: 266 MRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAY-TGAAIKKLRKEVFSARN 324

Query: 329 GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL 388
           GSR  + VPQ+ +L+T   SED+  +AA  L R G+  F +G   A+  +LE+IA +P+ 
Sbjct: 325 GSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAE 384

Query: 389 VYL--MDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESK--------RDILFLFDGS 438
            Y+  +  F+ L A  Q  ++ L   ++  V          K         DI  L DGS
Sbjct: 385 QYVSKLKTFADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGCVDTEEADIYLLIDGS 444

Query: 439 ANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVK 497
            +     F  ++ FL +++   N+ P   R+   QY+D   +E   +++ +K ++   ++
Sbjct: 445 GSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIE 504

Query: 498 RMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLK 557
            ++ + G   N G AL++      ++ A  +  + V   LV+L  G S D +  PA+ L+
Sbjct: 505 NIR-QMGGNTNTGAALNFT--LSLLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLR 561

Query: 558 QSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPV 617
           +  +  +    K A+  +L +I      +        + D+  Q+V  + +      A  
Sbjct: 562 EEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEICT----EEACK 617

Query: 618 SGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
             + D++FL+D S  +    F  +K F++ +V    +G DRV++ VVQ+SD  + EF LN
Sbjct: 618 EMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLN 677

Query: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 736
            +M++ D+ NA+ Q+  + G T  TG+AL FV       + G+R    + + LI++T   
Sbjct: 678 RFMSQSDISNAIDQMAHI-GQTTLTGSALSFV-SQYFSPTKGAR--PNIRKFLILITDGE 733

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISE 796
           + D V+ P+VV+++ G +   +G+  +++T+++ IS  P+    +  F  L  ++  +  
Sbjct: 734 AQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIEDDLVF 793

Query: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYL 855
            +    REE  R++ +             DVVF+ID S S    E+  ++  +  LV   
Sbjct: 794 GICS-PREECKRIEVL-------------DVVFVIDSSGSIDYDEYNIMKDFMIGLVKKA 839

Query: 856 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 915
           DVG +  R   ++++DDP+V F L+   +K EV + +Q  +  GG       AL + S +
Sbjct: 840 DVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGG-STYTAEALGF-SDH 897

Query: 916 IFKRPLGSRIEEGVPQFLVLISSGKSD--DEVDDPAVELKQFGVAPFTIA-RNADQEELV 972
           +F    GSR+ +GVPQ L++I+ G+S   D+++  A  L+  G+    +    A+  EL+
Sbjct: 898 MFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELL 957

Query: 973 KISLSPEYVFSVSTFRELPSL 993
            ++ S +  F V TF  L  +
Sbjct: 958 AMAGSSDKYFFVETFGGLKGI 978



 Score =  325 bits (833), Expect = 1e-88
 Identities = 246/801 (30%), Positives = 398/801 (49%), Gaps = 51/801 (6%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
            D++FL+D S  +G  +FP+V+ F+  +++SL I  D  RV L Q+SD   +EF L+T++ 
Sbjct: 27   DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKG 86

Query: 292  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
            +S +L HLR+     G  L  G AL   +  +F+     R ++  P +L++L + +SED+
Sbjct: 87   RSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDN 146

Query: 352  YLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQLIQPL 409
              +A+ AL + G+    VG  +A++  L+ +A +     L  + D S        +I+ +
Sbjct: 147  VEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKDV 206

Query: 410  TTYVSGGVEE--VPLAQPESKRDILFLFDGSAN-LVGQFPVVRDFLYKIIDELNVKPEGT 466
              Y  G V++  V   Q  S  D++FL D S N     F  ++ FL + +  L++K    
Sbjct: 207  IKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCM 266

Query: 467  RIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAG 526
            R+ +  YS++ KV +      +K E+L  ++ +  +TGKA   G A+   ++ +F    G
Sbjct: 267  RVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYT-GAAIKKLRKEVFSARNG 325

Query: 527  SRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFI 586
            SR   GV Q  VL+    S D V   A NL++ GV  F    + A   +LE+I   PA  
Sbjct: 326  SRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQ 385

Query: 587  LAAESLPKIGDLHPQIVNLLKSVHNGAPAPVS----------------GEKDVVFLLDGS 630
              ++ L    DL       LK + N     VS                 E D+  L+DGS
Sbjct: 386  YVSK-LKTFADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGCVDTEEADIYLLIDGS 444

Query: 631  EGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVR 689
               + + F  +K F+  VV   ++   +VRV  VQY+D    EF +N Y NKQD+  A+ 
Sbjct: 445  GSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIE 504

Query: 690  QLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVK 749
             +  +GG T NTGAAL F L   L+  A  +    VP  L+VLT   S D +  P+  ++
Sbjct: 505  NIRQMGGNT-NTGAALNFTLS--LLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLR 561

Query: 750  RGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ-QVISERVTQLTREELSR 808
                    IGI  A+ T+++ I+        +  F  L  ++ QV+ E  T+   +E+  
Sbjct: 562  EEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEICTEEACKEM-- 619

Query: 809  LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVI 867
                           K D++FL+D S S GPE F  ++T ++ LV    +G D  ++ V+
Sbjct: 620  ---------------KADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVV 664

Query: 868  QFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE 927
            QFSD  K EF LN   S+ ++ NA+ ++   G   +  G+AL +VS+  F    G+R   
Sbjct: 665  QFSDINKEEFQLNRFMSQSDISNAIDQMAHIGQTTL-TGSALSFVSQ-YFSPTKGAR--P 720

Query: 928  GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVST 986
             + +FL+LI+ G++ D V +PAV L+Q GV  +++    ++  +L +IS  PE VF V  
Sbjct: 721  NIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVEN 780

Query: 987  FRELPSLEQKLLTPITTLTSE 1007
            F  L  +E  L+  I +   E
Sbjct: 781  FDILQRIEDDLVFGICSPREE 801



 Score =  318 bits (816), Expect = 1e-86
 Identities = 221/776 (28%), Positives = 409/776 (52%), Gaps = 39/776 (5%)

Query: 32   IEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFY 91
            ++  + DI  L+DGS +    +F+ ++ F+++V+    I    ++V   QYAD+   EF 
Sbjct: 430  VDTEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFE 489

Query: 92   FNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITG 151
             N +  K+++  A+  ++ + G+   TG+AL+F  + L    A  +    +P  LV++T 
Sbjct: 490  INKYSNKQDLGKAIENIRQMGGNT-NTGAALNFTLSLL--QKAKKQRGNKVPCHLVVLTN 546

Query: 152  GKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLP 211
            G S D I +PA  L+   I  +AIG K A+Q +L EIA +   V+   +F A  L+ +  
Sbjct: 547  GMSKDSILEPANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDA--LKDIRN 604

Query: 212  GLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRV 271
             ++  + T     E+   K DI+FL+D S ++G  NF  ++ F+ NLV+   IG D +++
Sbjct: 605  QVVQEICTEEACKEM---KADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQI 661

Query: 272  GLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR 331
            G+VQFSD    EF LN + ++SDI   + Q+   G + L TGSALS+V + +F+   G+ 
Sbjct: 662  GVVQFSDINKEEFQLNRFMSQSDISNAIDQMAHIGQTTL-TGSALSFV-SQYFSPTKGA- 718

Query: 332  IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL 391
             R ++ + L+L+T G+++D   + A  L + G++ + VG   +N  +LE+I+  P +V+ 
Sbjct: 719  -RPNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFY 777

Query: 392  MDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKR----DILFLFDGSANL-VGQFP 446
            +++F  L  +   L+  + +            + E KR    D++F+ D S ++   ++ 
Sbjct: 778  VENFDILQRIEDDLVFGICS-----------PREECKRIEVLDVVFVIDSSGSIDYDEYN 826

Query: 447  VVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKA 506
            +++DF+  ++ + +V     R    +Y+DD +V    D+  +K E++++++  +   G  
Sbjct: 827  IMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGST 886

Query: 507  LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS--SDRVDGPASNLKQSGVVPF 564
                 AL ++  ++F ++ GSR+  GV Q L+++  G S  +D+++  A  L+  G++  
Sbjct: 887  YT-AEALGFSD-HMFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVL 944

Query: 565  IFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEK-DV 623
                  A+P EL  +  S       E+    G L     ++  SV N +      +K D+
Sbjct: 945  AVGIDGANPVELLAMAGSSDKYFFVET---FGGLKGIFSDVTASVCNSSKVDCEIDKVDL 1001

Query: 624  VFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQ 682
            VFL+DGS  ++ + F  +KEF+  VV+  DV  +RVR+   Q+SD   PEF L +++ ++
Sbjct: 1002 VFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEK 1061

Query: 683  DVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVR 742
            ++   +  +  + G T + GAAL  V  +      GSRI  G PQ+L+VLT  +S D+V 
Sbjct: 1062 EISFQIENIKQIFGNT-HIGAALREV-EHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVA 1119

Query: 743  NPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERV 798
              +  ++  G     +GIG+ D  ++  I+   +  + +  F +L  V + I   +
Sbjct: 1120 QAAEALRHRGIDIYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNI 1175



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 70/365 (19%), Positives = 148/365 (40%), Gaps = 41/365 (11%)

Query: 425  PESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVK----PEGTRIAVAQYSDDVKV 479
            P    +++F  D S ++  Q F  +++ +  ++ ++ V+    P G  IA+  Y+   + 
Sbjct: 1752 PVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARH 1811

Query: 480  ESRFDEHQSKPEILNLVKRMKIKTGKA-LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLV 538
              RF +   K ++L  ++ +  +   A   +G A+ +  R +F ++        +  F  
Sbjct: 1812 LVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTLPGAHTRKIATF-- 1869

Query: 539  LLVAGRSSD--RVDGPASNLKQSGVVPFIFQAKNA---------DPAELEQIVLSPA--- 584
               +G+S+D   +   A       ++P +    N          D     Q+++ P+   
Sbjct: 1870 -FSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGAD 1928

Query: 585  FILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSG-FPLLKEF 643
            +I A E L +    +  +     S     P PV    D  FLLD S  + S  F  ++ F
Sbjct: 1929 YIPALERLQRCTFCY-DVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIRAF 1987

Query: 644  VQRVVESLDVGQDRV------RVAVVQYS----------DRTRPEFYLNSYMNKQDVVNA 687
            +  +++  ++  +        RVA++ ++             R EF L +Y +K+ +   
Sbjct: 1988 LGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRH 2047

Query: 688  VRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVV 747
            V +           G AL++ L N+ +S+   R  + +  +    T+   G+ ++  S+ 
Sbjct: 2048 VHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNKVIFVISAGETSHLDGEILKKESLR 2107

Query: 748  VKRGG 752
             K  G
Sbjct: 2108 AKCQG 2112



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 84/412 (20%), Positives = 160/412 (38%), Gaps = 72/412 (17%)

Query: 222  GTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVG--------- 272
            G PE   +  +++F LD S +V +  F  +++ +  LV  + +  ++  VG         
Sbjct: 1747 GKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYN 1806

Query: 273  -----LVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGS-GLNTGSALSYVYANHFTE 326
                 LV+FSD             KS +L  +  +  +  S     G A+ ++  N F  
Sbjct: 1807 SHARHLVRFSDA----------YKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKR 1856

Query: 327  AGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQ-IAFN 385
               +    H  ++    ++GQS D++     A+    +    V  + +N   + +  A +
Sbjct: 1857 ---TLPGAHTRKIATFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAID 1913

Query: 386  PS----LVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP---ESKRDILFLFDGS 438
             +    ++ +      +PAL +         V         A+P   +S  D  FL D S
Sbjct: 1914 DTGTFQVIVVPSGADYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDAS 1973

Query: 439  ANL-VGQFPVVRDFLYKIIDELNVKPE------GTRIAVAQYS----------DDVKVES 481
             N+   +F  +R FL  ++D   + PE      G R+A+  ++            V+ E 
Sbjct: 1974 RNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEF 2033

Query: 482  RFDEHQSKPEILNLVKRMKIKTGKALN----LGYALDYAQRYIFVKSAGSRIEDGVLQFL 537
                ++SK     L+KR   ++ K LN    +G+AL +    +F+ +   R        +
Sbjct: 2034 NLTTYRSK----RLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNK-----V 2084

Query: 538  VLLVAGRSSDRVDG-----PASNLKQSGVVPFIFQAKNA-DPAELEQIVLSP 583
            + +++   +  +DG      +   K  G   F+F      D  ELE +   P
Sbjct: 2085 IFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDDKELEDLASHP 2136



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 85/396 (21%), Positives = 153/396 (38%), Gaps = 55/396 (13%)

Query: 34   VNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQV----AVAQYADTVRPE 89
            V+  ++VF +D S  +    F  +++ +A +++ +++ ++   V    A+  Y    R  
Sbjct: 1753 VHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARHL 1812

Query: 90   FYFNTHPTKREVITAVRKMKPLDGSALYT-GSALDFVRNNLFTSSAGYRAAEGIPKLLVL 148
              F+    K +++  +  +     SA    G A+ F+  N+F  +          K+   
Sbjct: 1813 VRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTL---PGAHTRKIATF 1869

Query: 149  ITGGKSLD--EISQPAQELKRSSIM--------------AFAIGNKGADQAELEEIAFDS 192
             + G+S D   I+  A E     I+              AFAI + G  Q     I   S
Sbjct: 1870 FSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQV----IVVPS 1925

Query: 193  SLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVR 252
               +IPA  R                     P    +  D  FLLD S N+G   F  +R
Sbjct: 1926 GADYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIR 1985

Query: 253  DFVMNLVNSLDIGND------NIRVGLVQFS---------DTPV-TEFSLNTYQTKSDIL 296
             F+  L++  +I  +        RV L+  +          +PV  EF+L TY++K  + 
Sbjct: 1986 AFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMK 2045

Query: 297  GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE--DSYLQ 354
             H+ +   Q       G AL +   N F      R      +++ +++AG++   D  + 
Sbjct: 2046 RHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRN----KVIFVISAGETSHLDGEIL 2101

Query: 355  AANALTRA----GILTFCVGASQANKAELEQIAFNP 386
               +L        +  F +G    +K ELE +A +P
Sbjct: 2102 KKESLRAKCQGYALFVFSLGPIWDDK-ELEDLASHP 2136



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 38/162 (23%), Positives = 72/162 (44%), Gaps = 22/162 (13%)

Query: 818  SPGVGGK-------RDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDT----TRVA 865
            SPG  GK        ++VF +D S+     EF+ ++ ++  LV  + V  ++      +A
Sbjct: 1742 SPGRHGKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIA 1801

Query: 866  VIQFSDDPKVEFLLNAHSSKDEVQNAVQRL---RPKGGRQINVGNALEYVSRNIFKRPLG 922
            ++ ++   +     +    K ++   ++ +   R    R+I  G A+ ++SRN+FKR L 
Sbjct: 1802 ILSYNSHARHLVRFSDAYKKSQLLREIETIPYERSSASREI--GRAMRFISRNVFKRTLP 1859

Query: 923  SRIEEGVPQFLVLISSGKSDD--EVDDPAVELKQFGVAPFTI 962
                  +  F    SSG+S D   +   A+E     + P  I
Sbjct: 1860 GAHTRKIATF---FSSGQSADAHSITTAAMEFGALEIIPVVI 1898


>gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]
          Length = 2526

 Score =  332 bits (851), Expect = 1e-90
 Identities = 261/988 (26%), Positives = 484/988 (48%), Gaps = 72/988 (7%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VFLVD S  LG  +F  ++ FI K+I  L I  +  +VA+AQY+D    EF+ +T   
Sbjct: 30  DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           +  ++  ++K     G +L  G AL       F++    R  +  P +LV++   +S DE
Sbjct: 90  RSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESEDE 149

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA-----FDSSLVFIPAEFRAAPLQGMLPG 212
           + + ++ L++  +   ++G + A +  L+ +A     F+   +   + F     Q +   
Sbjct: 150 VEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRTIRDLSTFSQNMTQIIKDV 209

Query: 213 LLAPLRTLSGTPEVH-------SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIG 265
                  +    +VH        +  D++FL+D S   G  N  +++ F+ N+ +S+D+ 
Sbjct: 210 TKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTG-GNLRHLQTFLENITSSMDVK 268

Query: 266 NDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFT 325
            + +R+GL+ +S++  T   L +  T+S+    ++ L +Q G   NTG+A+  +  + F+
Sbjct: 269 ENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAAIDQMRRDGFS 327

Query: 326 EAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFN 385
           E+ GSR  + VPQ+ +L+T   S+D    AA  L    +  F +    AN  +LE+I   
Sbjct: 328 ESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEIVSY 387

Query: 386 PSLVYL--------MDDFSS--LPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLF 435
           P    +        ++ +S+  L  L  ++   ++TY      +        + DI FL 
Sbjct: 388 PPEQTISTLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADIHFLI 447

Query: 436 DGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILN 494
           DGS+++   QF  ++ F+ ++ +  ++ P+  R+ V QYSDD +VE    ++ +  ++  
Sbjct: 448 DGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRK 507

Query: 495 LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPAS 554
            +  +K  TG     G ALDY  +   +K+        V  +L++L  G S+DRV  PA 
Sbjct: 508 AIFNIKQLTGGTYT-GKALDYILQ--IIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAK 564

Query: 555 NLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAP 614
            L+   +         A+  EL++I          E     G    Q  + LKS+ N   
Sbjct: 565 RLRAEQITVHAVGIGAANKIELQEIA-------GKEERVSFG----QNFDALKSIKNEVV 613

Query: 615 APVSGEK-------DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYS 666
             +  EK       D++FL+D S  +    F  +K F++ ++  + +G D+ ++ VVQ+S
Sbjct: 614 REICAEKGCEDMKADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQFS 673

Query: 667 DRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP 726
           D+T+ EF LN Y  +Q++ +A+ +++L+   T  TG AL FV       S G+R+  G  
Sbjct: 674 DKTKEEFQLNRYFTQQEISDAIDRMSLINEGT-LTGKALNFV-GQYFTHSKGARL--GAK 729

Query: 727 QLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQ 786
           + LI++T   + DDVR+P+ +++        +G+ NA+ ++++ IS        +  F  
Sbjct: 730 KFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSSLVFHVENFDH 789

Query: 787 LGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQ-YVR 845
           L  +++ +  RV  L   +  R+  +             DVVF++D S S   ++Q ++ 
Sbjct: 790 LKALERKLIFRVCAL--HDCKRITLL-------------DVVFVLDHSGSIKKQYQDHMI 834

Query: 846 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 905
            L   LV   DVG D  +   +++SD P + F LN +S++  +   +++ R  GG     
Sbjct: 835 NLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSNRSAIIENLRKRRDTGGNTY-T 893

Query: 906 GNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS--DDEVDDPAVELKQFGVAPFTI- 962
             AL++ +  +F    GSRI++ V Q L++I+ G+S   D+++D A+EL+  G+  F + 
Sbjct: 894 AKALKHANA-LFTEEHGSRIKQNVKQMLIVITDGESHDHDQLNDTALELRNKGITIFAVG 952

Query: 963 ARNADQEELVKISLSPEYVFSVSTFREL 990
              A+Q+EL  ++ +      V  F +L
Sbjct: 953 VGKANQKELEGMAGNKNNTIYVDNFDKL 980



 Score =  328 bits (842), Expect = 1e-89
 Identities = 251/805 (31%), Positives = 407/805 (50%), Gaps = 62/805 (7%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
            D++FL+D S ++G  +FP+V+ F+  ++NSL I  +  RV L Q+SD   +EF L+T++ 
Sbjct: 30   DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89

Query: 292  KSDILGHLRQ-LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED 350
            +S +L HL++  Q  GGS L  G AL   +  +F+     R R+  P +L++L + +SED
Sbjct: 90   RSPMLNHLKKNFQFIGGS-LQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESED 148

Query: 351  SYLQAANALTRAGILTFCVGASQANKAELEQIA-----FNPSLVYLMDDFSSLPALPQQL 405
               +A+ AL + G+    VG  +A++  L+ +A     FN   +  + D S+      Q+
Sbjct: 149  EVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFN---LRTIRDLSTFSQNMTQI 205

Query: 406  IQPLTTYVSGGVE-----EVPLA-QPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 459
            I+ +T Y  G V+       P++ Q +S  D++FL D S    G    ++ FL  I   +
Sbjct: 206  IKDVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTGGNLRHLQTFLENITSSM 265

Query: 460  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 519
            +VK    R+ +  YS+  K  S      ++ E    +K + I+ GK+ N G A+D  +R 
Sbjct: 266  DVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAAIDQMRRD 324

Query: 520  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 579
             F +S GSR   GV Q  VL+    S D V   A NL+   V  F    + A+  +LE+I
Sbjct: 325  GFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEI 384

Query: 580  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVS----------------GEKDV 623
            V  P       +L    DL       LK + N   + +S                 E D+
Sbjct: 385  VSYPP-EQTISTLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADI 443

Query: 624  VFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQ 682
             FL+DGS  ++   F  +K F+  V E   +G D+VRV VVQYSD T  EFY+  Y N  
Sbjct: 444  HFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDI 503

Query: 683  DVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVR 742
            D+  A+  +  L G T  TG AL+++L+ I+ +    R+++ VP  LIVLT   S D V 
Sbjct: 504  DLRKAIFNIKQLTGGT-YTGKALDYILQ-IIKNGMKDRMSK-VPCYLIVLTDGMSTDRVV 560

Query: 743  NPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ-QVISERVTQL 801
             P+  ++        +GIG A+  E+Q I+   +       F  L +++ +V+ E   + 
Sbjct: 561  EPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVREICAEK 620

Query: 802  TREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFD 860
              E++                 K D++FL+D S S G E F+ ++  ++ L+  + +G D
Sbjct: 621  GCEDM-----------------KADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGAD 663

Query: 861  TTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRP 920
             T++ V+QFSD  K EF LN + ++ E+ +A+ R+       +  G AL +V +  F   
Sbjct: 664  KTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTL-TGKALNFVGQ-YFTHS 721

Query: 921  LGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE 979
             G+R+  G  +FL+LI+ G + D+V DPA  L+   V  F++   NA++ +L +IS    
Sbjct: 722  KGARL--GAKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSS 779

Query: 980  YVFSVSTFRELPSLEQKLLTPITTL 1004
             VF V  F  L +LE+KL+  +  L
Sbjct: 780  LVFHVENFDHLKALERKLIFRVCAL 804



 Score =  326 bits (836), Expect = 6e-89
 Identities = 262/980 (26%), Positives = 475/980 (48%), Gaps = 61/980 (6%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
            D+VFLVD S   G  N   ++ F+  +   +++ ++ +++ +  Y+++ +   +  +  T
Sbjct: 236  DLVFLVDESLGTG-GNLRHLQTFLENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTT 294

Query: 98   KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
            + E    ++ +    G +  TG+A+D +R + F+ S G R A+G+P++ VL+T   S DE
Sbjct: 295  QSEFQQQIKNLSIQVGKS-NTGAAIDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDE 353

Query: 158  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPL 217
            +   A  L+   +  FA+  +GA+  +LEEI        I      A L+      L  L
Sbjct: 354  VHDAALNLRLEDVNVFALSIQGANNTQLEEIVSYPPEQTISTLKSYADLETYSTKFLKKL 413

Query: 218  --------------RTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                          R L  T  V + + DI FL+DGS+++ +  F  ++ F++ +     
Sbjct: 414  QNEIWSQISTYAEQRNLDKTGCVDTKEADIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFS 473

Query: 264  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQL-QLQGGSGLNTGSALSYVYAN 322
            IG D +RVG+VQ+SD    EF +  Y    D+   +  + QL GG+   TG AL Y+   
Sbjct: 474  IGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRKAIFNIKQLTGGT--YTGKALDYIL-- 529

Query: 323  HFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
               + G       VP  L++LT G S D  ++ A  L    I    VG   ANK EL++I
Sbjct: 530  QIIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAKRLRAEQITVHAVGIGAANKIELQEI 589

Query: 383  AFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLV 442
            A     V    +F +L ++  ++++ +      G E++       K DI+FL D S ++ 
Sbjct: 590  AGKEERVSFGQNFDALKSIKNEVVREIC--AEKGCEDM-------KADIMFLVDSSWSIG 640

Query: 443  GQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKI 501
             + F  ++ F+  ++ ++ +  + T+I V Q+SD  K E + + + ++ EI + + RM +
Sbjct: 641  NENFRKMKIFMKNLLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSL 700

Query: 502  KTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 561
                 L  G AL++  +Y F  S G+R+  G  +FL+L+  G + D V  PA  L+   V
Sbjct: 701  INEGTLT-GKALNFVGQY-FTHSKGARL--GAKKFLILITDGVAQDDVRDPARILRGKDV 756

Query: 562  VPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEK 621
              F     NA+ ++LE+I    + +   E+   +  L  +++  + ++H+     +    
Sbjct: 757  TIFSVGVYNANRSQLEEISGDSSLVFHVENFDHLKALERKLIFRVCALHDCKRITL---L 813

Query: 622  DVVFLLDGSEGVRSGF-PLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
            DVVF+LD S  ++  +   +      +V+  DVG+DRV+   ++YSD+    FYLN+Y N
Sbjct: 814  DVVFVLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSN 873

Query: 681  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRS--G 738
            +  ++  +R+    GG T  T  AL+     +     GSRI + V Q+LIV+T   S   
Sbjct: 874  RSAIIENLRKRRDTGGNT-YTAKALKHA-NALFTEEHGSRIKQNVKQMLIVITDGESHDH 931

Query: 739  DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERV 798
            D + + ++ ++  G     +G+G A+  E++ ++   +  + +  F +L  V  ++ ER+
Sbjct: 932  DQLNDTALELRNKGITIFAVGVGKANQKELEGMAGNKNNTIYVDNFDKLKDVFTLVQERM 991

Query: 799  TQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIERLVDYLDV 857
                  E+  LQ             + DV+FL DGS + +  +F  + T +  L+D  D+
Sbjct: 992  C-TEAPEVCHLQ-------------EADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDI 1037

Query: 858  GFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIF 917
                 ++ + QF  + +    L    +K + +  +Q +   GG    +  AL+ VS N+F
Sbjct: 1038 QSQRMKIGMAQFGSNYQSIIELKNSLTKTQWKTQIQNVSKSGGFP-RIDFALKKVS-NMF 1095

Query: 918  KRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISL 976
                G R   GVPQ LV+I+SG    +V D    LK  G+    +   +  +E L+ I+ 
Sbjct: 1096 NLHAGGRRNAGVPQTLVVITSGDPRYDVADAVKTLKDLGICVLVLGIGDVYKEHLLPITG 1155

Query: 977  SPEYVFSVSTFRELPSLEQK 996
            + E + +   F +L +++ K
Sbjct: 1156 NSEKIITFQDFDKLKNVDVK 1175



 Score =  263 bits (673), Expect = 5e-70
 Identities = 210/755 (27%), Positives = 375/755 (49%), Gaps = 46/755 (6%)

Query: 22   TTHAQQQQ----AVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQV 77
            +T+A+Q+       ++  + DI FL+DGSS++    F  I+ F+ +V +   IG D ++V
Sbjct: 422  STYAEQRNLDKTGCVDTKEADIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRV 481

Query: 78   AVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR 137
             V QY+D    EFY   +    ++  A+  +K L G   YTG ALD++   +  +    R
Sbjct: 482  GVVQYSDDTEVEFYITDYSNDIDLRKAIFNIKQLTGGT-YTGKALDYILQ-IIKNGMKDR 539

Query: 138  AAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFI 197
             ++ +P  L+++T G S D + +PA+ L+   I   A+G   A++ EL+EIA     V  
Sbjct: 540  MSK-VPCYLIVLTDGMSTDRVVEPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSF 598

Query: 198  PAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMN 257
               F A  L+ +   ++  +    G  ++   K DI+FL+D S ++G  NF  ++ F+ N
Sbjct: 599  GQNFDA--LKSIKNEVVREICAEKGCEDM---KADIMFLVDSSWSIGNENFRKMKIFMKN 653

Query: 258  LVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALS 317
            L+  + IG D  ++G+VQFSD    EF LN Y T+ +I   + ++ L    G  TG AL+
Sbjct: 654  LLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSLI-NEGTLTGKALN 712

Query: 318  YVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKA 377
            +V   +FT + G+R+     + L+L+T G ++D     A  L    +  F VG   AN++
Sbjct: 713  FV-GQYFTHSKGARL--GAKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRS 769

Query: 378  ELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKR----DILF 433
            +LE+I+ + SLV+ +++F  L AL ++LI  +             A  + KR    D++F
Sbjct: 770  QLEEISGDSSLVFHVENFDHLKALERKLIFRV------------CALHDCKRITLLDVVF 817

Query: 434  LFDGSANLVGQF-PVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEI 492
            + D S ++  Q+   + +    ++ + +V  +  +    +YSD   +    + + ++  I
Sbjct: 818  VLDHSGSIKKQYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSNRSAI 877

Query: 493  L-NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS--SDRV 549
            + NL KR    TG       AL +A   +F +  GSRI+  V Q L+++  G S   D++
Sbjct: 878  IENLRKRR--DTGGNTYTAKALKHANA-LFTEEHGSRIKQNVKQMLIVITDGESHDHDQL 934

Query: 550  DGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSV 609
            +  A  L+  G+  F      A+  ELE +  +    +  ++  K+ D+   +    + +
Sbjct: 935  NDTALELRNKGITIFAVGVGKANQKELEGMAGNKNNTIYVDNFDKLKDVFTLV---QERM 991

Query: 610  HNGAPAPVS-GEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSD 667
               AP      E DV+FL DGS+ V  S F  +  F+  ++++ D+   R+++ + Q+  
Sbjct: 992  CTEAPEVCHLQEADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGS 1051

Query: 668  RTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQ 727
              +    L + + K      ++ ++  GG  P    AL+ V  N+    AG R   GVPQ
Sbjct: 1052 NYQSIIELKNSLTKTQWKTQIQNVSKSGG-FPRIDFALKKV-SNMFNLHAGGRRNAGVPQ 1109

Query: 728  LLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN 762
             L+V+T+     DV +    +K  G   + +GIG+
Sbjct: 1110 TLVVITSGDPRYDVADAVKTLKDLGICVLVLGIGD 1144



 Score =  157 bits (396), Expect = 6e-38
 Identities = 111/406 (27%), Positives = 202/406 (49%), Gaps = 14/406 (3%)

Query: 613  APAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRP 671
            +P P     DVVFL+D S+ +    FP +K F+ +++ SL +  ++ RVA+ QYSD    
Sbjct: 21   SPGPGPVYADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHS 80

Query: 672  EFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 731
            EF+L+++  +  ++N +++     G +   G AL+   R    +    R  +  P +L+V
Sbjct: 81   EFHLSTFKGRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVV 140

Query: 732  LTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ 791
            L +  S D+V   S  +++ G   I +G+  A    ++ ++    F   + T R L T  
Sbjct: 141  LASAESEDEVEEASKALQKDGVKIISVGVQKASEENLKAMA-TSHFHFNLRTIRDLSTFS 199

Query: 792  QVISERVTQLTREELSRLQPVLQ---PLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLI 848
            Q +++ +  +T+ +   +   +Q   P+ S       D+VFL+D S   G   ++++T +
Sbjct: 200  QNMTQIIKDVTKYKEGAVDADMQVHFPI-SCQKDSLADLVFLVDESLGTGGNLRHLQTFL 258

Query: 849  ERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNA 908
            E +   +DV  +  R+ ++ +S+  K    L + +++ E Q  ++ L  + G+  N G A
Sbjct: 259  ENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAA 317

Query: 909  LEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI----AR 964
            ++ + R+ F    GSR  +GVPQ  VL++   SDDEV D A+ L+   V  F +    A 
Sbjct: 318  IDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGAN 377

Query: 965  NADQEELVKISLSPEYVFS-VSTFRELPSLEQKLLTPITTLTSEQI 1009
            N   EE+V  S  PE   S + ++ +L +   K L  +      QI
Sbjct: 378  NTQLEEIV--SYPPEQTISTLKSYADLETYSTKFLKKLQNEIWSQI 421



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 78/381 (20%), Positives = 161/381 (42%), Gaps = 39/381 (10%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 93
            ++VF +D S  +   +FN  RD I  ++  L I ++      +VA+  Y         ++
Sbjct: 1758 ELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSYLIRWS 1817

Query: 94   THPTKREVITAVRKMKPLDGSALY-TGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGG 152
             +  K++++  + ++K  D +     G+A+ FV  N+F  +    A   + ++ V  + G
Sbjct: 1818 DYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTY---AGANVRRVAVFFSNG 1874

Query: 153  KSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVF----IPAEFRAAPLQG 208
            ++    S     ++ S++          ++  LE   FD++  F    +P       L+ 
Sbjct: 1875 QTASRSSIITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNGENQTLER 1934

Query: 209  MLPGLLA-----PLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
            +    L      P   +        +  D++FL+D S N+ K  F  V+  V +++++ +
Sbjct: 1935 LRRCALCYDKCFPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFN 1994

Query: 264  IGNDNI------RVGLVQFS---------DTPVTEFSLNTYQTKSDILGHLRQLQLQGGS 308
            I +D +      R+ L+ +S          T  TEF   TY  +  +  H++    Q   
Sbjct: 1995 IASDPLISDSGDRIALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNG 2054

Query: 309  GLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRA---GIL 365
                G AL +   N F E     +R+H  +++ +++AG++ +          RA   G +
Sbjct: 2055 EATIGRALLWTTENLFPET--PYLRKH--KVIFVVSAGENYERKEFVKMMALRAKCQGYV 2110

Query: 366  TFCVGASQANKAELEQIAFNP 386
             F +      K ++E++A  P
Sbjct: 2111 IFVISLGSTRKDDMEELASYP 2131



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)

Query: 425  PESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVK----PEGTRIAVAQYSDDVKV 479
            P    +++F  D S ++  + F   RD +  I+++LN++    P G R+A+  Y+     
Sbjct: 1753 PAYPTELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSY 1812

Query: 480  ESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKS-AGSRIEDGVLQFL 537
              R+ ++  K ++L  + ++K + T +  ++G A+ +  R +F ++ AG+ +    + F 
Sbjct: 1813 LIRWSDYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAGANVRRVAVFFS 1872

Query: 538  VLLVAGRSSDRVDGPASNLKQSGVVPFIF--------QAKNADPAELEQIVLSP--AFIL 587
                A RSS  +           + P +F        +A   D     Q++  P      
Sbjct: 1873 NGQTASRSS--IITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNGENQ 1930

Query: 588  AAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQR 646
              E L +    + +      +    A  P     DVVFL+D S  + +  F  +K  V  
Sbjct: 1931 TLERLRRCALCYDKC--FPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSS 1988

Query: 647  VVESLDVGQDRV------RVAVVQYS 666
            V+++ ++  D +      R+A++ YS
Sbjct: 1989 VIDNFNIASDPLISDSGDRIALLSYS 2014



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 32/146 (21%), Positives = 68/146 (46%), Gaps = 11/146 (7%)

Query: 826  DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 880
            ++VF +D S     E F   R +I  +V+ L++  +      RVA++ ++         +
Sbjct: 1758 ELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSYLIRWS 1817

Query: 881  AHSSKDEVQNAVQRLRPKGGRQI-NVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 939
             ++ K ++   + +++ +   +  +VGNA+ +V+RN+FKR         V +  V  S+G
Sbjct: 1818 DYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAG---ANVRRVAVFFSNG 1874

Query: 940  K--SDDEVDDPAVELKQFGVAPFTIA 963
            +  S   +    +E     ++P   A
Sbjct: 1875 QTASRSSIITATMEFSALDISPTVFA 1900


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score =  171 bits (433), Expect = 3e-42
 Identities = 158/607 (26%), Positives = 273/607 (44%), Gaps = 59/607 (9%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
            D+VFL+DGSS L  A F  ++ F+  +++RL I Q  ++VAV +Y D             
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 98   KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
              E+     ++K        T   L +    +F+      A+    ++ +L+   +    
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEAS----RITLLLMASQEPQR 1392

Query: 158  ISQP----AQELKRSSIMAFAIG-------------------NKG-----ADQAELEEIA 189
            +S+      Q LK+  ++   +G                   NK       D+ E +   
Sbjct: 1393 MSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDE 1452

Query: 190  FDSSLVFIPAEFRAAPLQGML------PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANV 243
              S L  +  E     L   +      PGLL  + TL   P+ +S   D+ F+L+GS  +
Sbjct: 1453 IVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLG-VSTLG--PKRNSMVLDVAFVLEGSDKI 1509

Query: 244  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 303
            G+ +F   ++F+  ++  +D+G D+I V ++Q+S     E+  +  Q+K DIL  +R+++
Sbjct: 1510 GEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIR 1569

Query: 304  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 363
             QGG+  NTG AL Y+  + F  + G   RE  P L+ ++T   + D   +    +    
Sbjct: 1570 YQGGNRTNTGLALRYLSDHSFLVSQGD--REQAPNLVYMVTGNPASDEIKRLPGDIQ--- 1624

Query: 364  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLA 423
            ++   VG + AN  ELE+I + P+   L+ DF +LP     L+  L    SG   ++P  
Sbjct: 1625 VVPIGVGPN-ANVQELERIGW-PNAPILIQDFETLPREAPDLV--LQRCCSGEGLQIPTL 1680

Query: 424  QP----ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVK 478
             P        D++ L DGS++     F  ++ F    I + N+ P  T+++V QY     
Sbjct: 1681 SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT 1740

Query: 479  VESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLV 538
            ++  ++    K  +L+LV  M+ + G    +G AL +A RY+  +  G+R   G  + +V
Sbjct: 1741 IDVPWNVVPEKAHLLSLVDVMQ-REGGPSQIGDALGFAVRYLTSEMHGAR--PGASKAVV 1797

Query: 539  LLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDL 598
            +LV   S D VD  A   + + V  F     +   A   +I+  PA       L +I DL
Sbjct: 1798 ILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDL 1857

Query: 599  HPQIVNL 605
             P +V L
Sbjct: 1858 -PTMVTL 1863



 Score =  149 bits (377), Expect = 1e-35
 Identities = 152/600 (25%), Positives = 268/600 (44%), Gaps = 69/600 (11%)

Query: 406  IQPLTTYVSGGVEEVPLAQPESKR--DILFLFDGSANLV-GQFPVVRDFLYKIIDELNVK 462
            + P T YV   + E PL      R  D++FL DGS+ L   +F V++ F+  +++ L + 
Sbjct: 1252 VSPTTLYVED-ISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRIS 1310

Query: 463  PEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFV 522
             +  R+AV +Y D         + +   E+  +  ++K    +  +    L Y    IF 
Sbjct: 1311 QKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFS 1370

Query: 523  K---SAGSRIEDGVLQFLVLLVAGRSSDRVD----------------------GPASNLK 557
            K      SRI        +LL+A +   R+                       GP +NLK
Sbjct: 1371 KIDRPEASRIT-------LLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLK 1423

Query: 558  QSGVVP--------FIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNL---- 605
            Q  ++         F+  + +    + ++IV S    LA E+ P    L P +  +    
Sbjct: 1424 QIRLIEKQAPENKAFVLSSVDELEQQRDEIV-SYLCDLAPEAPPPT--LPPDMAQVTVGP 1480

Query: 606  -LKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVV 663
             L  V    P   S   DV F+L+GS+ +  + F   KEF++ V++ +DVGQD + V V+
Sbjct: 1481 GLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVL 1540

Query: 664  QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 723
            QYS     E+  +   +K D++  VR++   GG   NTG AL ++  +  + S G R  E
Sbjct: 1541 QYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDR--E 1598

Query: 724  GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 783
              P L+ ++T + + D+++     ++    VPIG+G  NA++ E++ I + P+  + I  
Sbjct: 1599 QAPNLVYMVTGNPASDEIKRLPGDIQ---VVPIGVG-PNANVQELERIGW-PNAPILIQD 1653

Query: 784  FRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQS-AGPEFQ 842
            F    T+ +   + V Q          P L   P+P      DV+ L+DGS S     F 
Sbjct: 1654 FE---TLPREAPDLVLQRCCSGEGLQIPTLS--PAPDCSQPLDVILLLDGSSSFPASYFD 1708

Query: 843  YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 902
             +++  +  +   ++G   T+V+V+Q+     ++   N    K  + + V  ++ +GG  
Sbjct: 1709 EMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPS 1768

Query: 903  INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 962
              +G+AL +  R +     G+R   G  + +V++ +  S D VD  A   +   V  F I
Sbjct: 1769 -QIGDALGFAVRYLTSEMHGAR--PGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPI 1825



 Score =  137 bits (346), Expect = 4e-32
 Identities = 155/601 (25%), Positives = 262/601 (43%), Gaps = 76/601 (12%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
            D++FLLDGS+ + +  F  ++ FV++++  L I    +RV +V++ D       L   + 
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 292  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED- 350
             S++     Q++  G    +T   L Y     F++      R    ++ LLL A Q    
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKID----RPEASRITLLLMASQEPQR 1392

Query: 351  ---SYLQAANALTRAGILTFCVG---------------ASQANKA-------ELEQIAFN 385
               ++++    L +  ++   VG                +  NKA       ELEQ   +
Sbjct: 1393 MSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQ-QRD 1451

Query: 386  PSLVYLMD--DFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANL-V 442
              + YL D    +  P LP  + Q        GV  +   +     D+ F+ +GS  +  
Sbjct: 1452 EIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGE 1511

Query: 443  GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIK 502
              F   ++F+ ++I  ++V  +   + V QYS  V VE  F E QSK +IL  V+ ++ +
Sbjct: 1512 ADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQ 1571

Query: 503  TGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVV 562
             G   N G AL Y   + F+ S G R +   L ++V      +SD +     +++   VV
Sbjct: 1572 GGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMV--TGNPASDEIKRLPGDIQ---VV 1626

Query: 563  PFIFQAKNADPAELEQI--VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNG-------- 612
            P I    NA+  ELE+I    +P  I   E+LP+     P +V  L+   +G        
Sbjct: 1627 P-IGVGPNANVQELERIGWPNAPILIQDFETLPREA---PDLV--LQRCCSGEGLQIPTL 1680

Query: 613  APAP-VSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTR 670
            +PAP  S   DV+ LLDGS     S F  +K F +  +   ++G    +V+V+QY   T 
Sbjct: 1681 SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT 1740

Query: 671  PEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLI 730
             +   N    K  +++ V  +   GGP+   G AL F +R +     G+R   G  + ++
Sbjct: 1741 IDVPWNVVPEKAHLLSLVDVMQREGGPS-QIGDALGFAVRYLTSEMHGAR--PGASKAVV 1797

Query: 731  VLTADRSGDDVRNPSVVVK--RGGAVPIGIG--------------IGNADITEMQTISFI 774
            +L  D S D V   +   +  R    PIGIG               G++++ ++Q I  +
Sbjct: 1798 ILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDL 1857

Query: 775  P 775
            P
Sbjct: 1858 P 1858



 Score =  130 bits (328), Expect = 5e-30
 Identities = 103/380 (27%), Positives = 185/380 (48%), Gaps = 32/380 (8%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
            D+ F+++GS  +G A+FN  ++F+ +VIQR+++GQD I V V QY+  V  E+ F+   +
Sbjct: 1498 DVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQS 1557

Query: 98   KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
            K +++  VR+++   G+   TG AL ++ ++ F  S G R  E  P L+ ++TG  + DE
Sbjct: 1558 KGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDR--EQAPNLVYMVTGNPASDE 1615

Query: 158  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFI------PAEFRAAPLQGMLP 211
            I +   +++   ++   +G   A+  ELE I + ++ + I      P E     LQ    
Sbjct: 1616 IKRLPGDIQ---VVPIGVG-PNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCS 1671

Query: 212  GLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRV 271
            G    + TLS  P+  S   D+I LLDGS++   + F  ++ F    ++  +IG    +V
Sbjct: 1672 GEGLQIPTLSPAPDC-SQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQV 1730

Query: 272  GLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR 331
             ++Q+      +   N    K+ +L  +  +Q +GG     G AL +      +E  G+ 
Sbjct: 1731 SVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPS-QIGDALGFAVRYLTSEMHGA- 1788

Query: 332  IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVG----------------ASQAN 375
             R    + +++L    S DS   AA+A     +  F +G                A  +N
Sbjct: 1789 -RPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSN 1847

Query: 376  KAELEQIAFNPSLVYLMDDF 395
              +L++I   P++V L + F
Sbjct: 1848 VVKLQRIEDLPTMVTLGNSF 1867


>gi|21359974 vitrin [Homo sapiens]
          Length = 693

 Score =  155 bits (392), Expect = 2e-37
 Identities = 114/389 (29%), Positives = 198/389 (50%), Gaps = 22/389 (5%)

Query: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
           K D+ FL+DGS+++G   F   +  +A V Q L+IG     + V QY D     F   TH
Sbjct: 306 KIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTH 365

Query: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
              R++ TA+ K+    G +   G A+ FV  N F+ + G R+  G P ++V++  G   
Sbjct: 366 TNSRDLKTAIEKITQRGGLS-NVGRAISFVTKNFFSKANGNRS--GAPNVVVVMVDGWPT 422

Query: 156 DEISQPAQELKRSSIMAFAIGNKGADQAELEEIA---FDSSLVFIPAEFRAAPLQGM--L 210
           D++ + ++  + S I  F I  +GA + E + +    F +  V     F +  +Q    L
Sbjct: 423 DKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGL 482

Query: 211 PGLLAPL-RTLSGTPEVHSNKR-----DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDI 264
              L PL + +  T  +  +K      DI F++DGS++VG  NF  V  FV NL    +I
Sbjct: 483 HKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEI 542

Query: 265 GNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHF 324
            + + R+G VQ++     EF  + Y +K DIL  ++++    G G +TG+A+++     F
Sbjct: 543 SDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLF 601

Query: 325 TEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAF 384
            ++     + +  +L++L+T G+S D     A A    G++T+ +G + A + ELE IA 
Sbjct: 602 KKS-----KPNKRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIAT 656

Query: 385 NPSL--VYLMDDFSSLPALPQQLIQPLTT 411
           +P+    + +D+F +L     ++IQ + T
Sbjct: 657 HPARDHSFFVDEFDNLHQYVPRIIQNICT 685



 Score =  147 bits (370), Expect = 7e-35
 Identities = 106/363 (29%), Positives = 177/363 (48%), Gaps = 17/363 (4%)

Query: 230 KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 289
           K D+ FL+DGS ++GK  F   +  + ++  +LDIG     +G+VQ+ D P T F+L T+
Sbjct: 306 KIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTH 365

Query: 290 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349
               D+   + ++  +GG   N G A+S+V  N F++A G+R     P +++++  G   
Sbjct: 366 TNSRDLKTAIEKITQRGGLS-NVGRAISFVTKNFFSKANGNR--SGAPNVVVVMVDGWPT 422

Query: 350 DSYLQAANALTRAGILTFCV---GASQANKAELEQIAFNPSLVYLMDDFSSLPALP---- 402
           D   +A+     +GI  F +   GA++  K  + +  F    V   + F SL        
Sbjct: 423 DKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGL 482

Query: 403 QQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNV 461
            + +QPL   V             +  DI F+ DGS+++  G F  V  F+  +  E  +
Sbjct: 483 HKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEI 542

Query: 462 KPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIF 521
               TRI   QY+ + ++E  FD++ SKP+ILN +KR+   +G   + G A+++A   +F
Sbjct: 543 SDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLF 601

Query: 522 VKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL 581
            KS  ++      + ++L+  GRS D V  PA      GV+ +      A   ELE I  
Sbjct: 602 KKSKPNK-----RKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIAT 656

Query: 582 SPA 584
            PA
Sbjct: 657 HPA 659



 Score =  122 bits (305), Expect = 2e-27
 Identities = 129/504 (25%), Positives = 220/504 (43%), Gaps = 48/504 (9%)

Query: 523  KSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAK-NADPAELEQIVL 581
            +S G R ++  L       + ++  R D        SG     FQ    AD +  E    
Sbjct: 217  QSVGHRSQEMDLWSTATYTSSQNRPRADPGIQRQDPSGAA---FQKPVGADVSLGEMDSW 273

Query: 582  SPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLL 640
             P  +L  E L    +L  Q    L+ V  G P   + + D+ FL+DGS  + +  F + 
Sbjct: 274  KPGSVLLDEGLVPKEELSTQS---LEPVSLGDP---NCKIDLSFLIDGSTSIGKRRFRIQ 327

Query: 641  KEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPN 700
            K+ +  V ++LD+G     + VVQY D     F L ++ N +D+  A+ ++T  GG   N
Sbjct: 328  KQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGG-LSN 386

Query: 701  TGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGI 760
             G A+ FV +N    + G+R   G P +++V+      D V   S + +  G     I I
Sbjct: 387  VGRAISFVTKNFFSKANGNR--SGAPNVVVVMVDGWPTDKVEEASRLARESGINIFFITI 444

Query: 761  GNADITEMQTISFIPDFA------------VAIPTFRQLGTVQQVISERVTQLTREELSR 808
              A   E Q +   P+FA            + + ++  L    Q + +RV    R   S+
Sbjct: 445  EGAAENEKQYV-VEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQPLVKRVCDTDRLACSK 503

Query: 809  LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVI 867
                             D+ F+IDGS S G   F+ V   +  L    ++    TR+  +
Sbjct: 504  T-----------CLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAV 552

Query: 868  QFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE 927
            Q++ + ++EF  + +SSK ++ NA++R+    G   + G A+ +    +FK+   ++   
Sbjct: 553  QYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLFKKSKPNK--- 608

Query: 928  GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSV 984
               + ++LI+ G+S D+V  PA+     GV  + I    A QEEL  I+  P  ++ F V
Sbjct: 609  --RKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFV 666

Query: 985  STFRELPSLEQKLLTPITTLTSEQ 1008
              F  L     +++  I T  + Q
Sbjct: 667  DEFDNLHQYVPRIIQNICTEFNSQ 690



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 50/156 (32%), Positives = 83/156 (53%), Gaps = 6/156 (3%)

Query: 34  VNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFN 93
           +N  DI F++DGSS++G  NF  +  F+  + +  EI     ++   QY    R EF F+
Sbjct: 506 LNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAVQYTYEQRLEFGFD 565

Query: 94  THPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGK 153
            + +K +++ A++++    G    TG+A++F    LF  S   +      KL++LIT G+
Sbjct: 566 KYSSKPDILNAIKRVGYWSGGT-STGAAINFALEQLFKKSKPNKR-----KLMILITDGR 619

Query: 154 SLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           S D++  PA       ++ +AIG   A Q ELE IA
Sbjct: 620 SYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIA 655


>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
          Length = 499

 Score =  143 bits (361), Expect = 7e-34
 Identities = 115/408 (28%), Positives = 197/408 (48%), Gaps = 43/408 (10%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++D S ++    F  +R F+  +++ L +G +  +V V QY+  V+  F       
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
           + ++  A+R + PL      TG A+ +  N  F+ + G R   E +P++ V++T G+  D
Sbjct: 94  REDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA-----------------------FDSS 193
            +++ A + +   I  +A+G + AD   L  +A                       F S 
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSR 212

Query: 194 L--------VFIPAEFRAAPLQGMLPGLLAPL-RTLSGTPEVHSNKR----DIIFLLDGS 240
           L        V    EF+    +G+    L P  R L    +  +  R    D++ L+DGS
Sbjct: 213 LCVRDLCNGVDHGCEFQCVS-EGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGS 271

Query: 241 ANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLR 300
            +V   NF  V+ FV  +V+ LD+  +  RVGLVQFS    TEF L  Y T +++   + 
Sbjct: 272 KSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVL 331

Query: 301 QLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSEDSYLQAANAL 359
            ++     G  TG AL ++  + F+EA G+R R  +VP++ L+ T G+S+D     A   
Sbjct: 332 AVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARA 390

Query: 360 TRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQL 405
              GI+ + VG  +A +AEL +IA  P+ +++    DF ++  L + L
Sbjct: 391 KEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 438



 Score =  132 bits (331), Expect = 2e-30
 Identities = 116/434 (26%), Positives = 201/434 (46%), Gaps = 41/434 (9%)

Query: 213 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 269
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 270 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 329
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 330 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 386
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 387 SLVYLMDDFSSLPALPQQL-----IQPLTTYVSGGVEEVPLAQ--------PESKR---- 429
             V+L++ F  +     Q      ++ L   V  G E   +++        PE ++    
Sbjct: 191 EHVFLVESFDLIQEFGLQFQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQAD 250

Query: 430 ------------DILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDD 476
                       D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  
Sbjct: 251 GKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSR 310

Query: 477 VKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQ 535
           V+ E     + +  E+   V  ++    +    G AL +   + F ++ G+R     V +
Sbjct: 311 VRTEFPLGRYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPR 369

Query: 536 FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKI 595
             ++   GRS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  
Sbjct: 370 VGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDF 428

Query: 596 GDLHPQIVNLLKSV 609
           G +   + NL  S+
Sbjct: 429 GTMTHLLENLRGSI 442



 Score =  124 bits (312), Expect = 4e-28
 Identities = 103/390 (26%), Positives = 187/390 (47%), Gaps = 31/390 (7%)

Query: 618 SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
           +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30  TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 735
           ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90  AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 736 RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQV 793
           R  D V   +   +  G     +G+  AD+  ++ ++  P  +    + +F  +      
Sbjct: 149 RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQ 208

Query: 794 ISERVT--------------QLTREELSR--LQPVLQPLPSPGVG------GKRDVVFLI 831
              R+               Q   E LS   L P  + L + G        G  D+V L+
Sbjct: 209 FQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLV 268

Query: 832 DGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQN 890
           DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  + +  EV+ 
Sbjct: 269 DGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQ 328

Query: 891 AVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPA 949
           AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+S D++   A
Sbjct: 329 AVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWA 387

Query: 950 VELKQFGVAPFTI-ARNADQEELVKISLSP 978
              K+ G+  + +    A + EL +I+  P
Sbjct: 388 ARAKEEGIVMYAVGVGKAVEAELREIASEP 417



 Score =  117 bits (292), Expect = 7e-26
 Identities = 111/398 (27%), Positives = 173/398 (43%), Gaps = 53/398 (13%)

Query: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 487
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 488 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRI-EDGVLQFLVLLVAGRSS 546
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA--FILAAESLPKIGDLHPQ--- 601
           DRV   A+  +  G+  +    + AD   L  +   P    +   ES   I +   Q   
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQS 211

Query: 602 ---IVNLLKSVHNGAPAPV----------------------------SGEKDVVFLLDGS 630
              + +L   V +G                                  G  D+V L+DGS
Sbjct: 212 RLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGS 271

Query: 631 EGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVR 689
           + VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  Y    +V  AV 
Sbjct: 272 KSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVL 331

Query: 690 QLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADRSGDDVRNPSVVV 748
            +  +   T  TG AL  ++ +    + G+R     VP++ +V T  RS DD+   +   
Sbjct: 332 AVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARA 390

Query: 749 KRGGAVPIGIGIGNADITEMQTI---------SFIPDF 777
           K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 391 KEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 428



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 59/184 (32%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+V LVDGS ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T
Sbjct: 263 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 322

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
             EV  AV  ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D
Sbjct: 323 AAEVKQAVLAVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 381

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLL 214
           +IS  A   K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL
Sbjct: 382 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLL 435

Query: 215 APLR 218
             LR
Sbjct: 436 ENLR 439



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 823 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31  GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 940
            S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91  FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 987
             D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150 PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199


>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
          Length = 496

 Score =  139 bits (351), Expect = 1e-32
 Identities = 118/413 (28%), Positives = 199/413 (48%), Gaps = 43/413 (10%)

Query: 622 DVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D+VF++D S  VR   F  +K F+ +V+ESLDVG +  RV +V Y+   + EF L ++++
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI-TEGVPQLLIVLTADRSGD 739
           K  ++ AVR++  L   T  TG A++F +      + G R  +  + +++IV+T  R  D
Sbjct: 101 KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159

Query: 740 DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-----DFAVAIPTFRQLGTVQQVI 794
            V++ S   +  G     IG+G+ D   ++ I+  P     D+  +     +L    Q  
Sbjct: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219

Query: 795 SERVTQLTREELSRLQPVLQPLPSP----------------------GVGGKR--DVVFL 830
              V+ L        + V    P                        G GG    D+VFL
Sbjct: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279

Query: 831 IDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQ 889
           IDGS+S  PE F+ V+  I ++VD LDV     +V ++Q+S   + EF L    +K +++
Sbjct: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339

Query: 890 NAVQRL--RPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDD 947
            AV+ +    KG      G AL+Y+  N F    G+R   G  +  ++ + G+S D ++D
Sbjct: 340 AAVRNMSYMEKG---TMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394

Query: 948 PAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 997
            A + K  G   F +   NA ++EL +I+  P  E+ F  + F+ +  + +KL
Sbjct: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447



 Score =  132 bits (333), Expect = 1e-30
 Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)

Query: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
           D++F+ D S ++   +F  V+ FL ++I+ L+V P  TR+ +  Y+  VK E     H S
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 489 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 546
           K  +L  V+R++ + TG     G A+ +A    F  + G R     +  +V++V  GR  
Sbjct: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 583
           D V   ++  + SGV  F     + D A L QI   P                       
Sbjct: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218

Query: 584 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 624
           AF + ++ L   GD   + V +        + H G      G+              D+V
Sbjct: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277

Query: 625 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 683
           FL+DGS+ VR   F L+K+F+ ++V++LDV     +V +VQYS   R EF L  +  K+D
Sbjct: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337

Query: 684 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 743
           +  AVR ++ +   T  TGAAL++++ N    S+G+R   G  ++ IV T  RS D + +
Sbjct: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394

Query: 744 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
            +   K  G     +G+GNA   E++ I+  P
Sbjct: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426



 Score =  129 bits (325), Expect = 1e-29
 Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++F++D S +V    F  V+ F+  ++ SLD+G +  RVG+V ++ T   EFSL  + +
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 350
           K+ +L  +R++Q    +G  TG A+ +     F +A G R R   + ++++++T G+ +D
Sbjct: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159

Query: 351 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 404
           S    +     +G+  F +G    +KA L QIA  P    V  ++ +S +  L ++    
Sbjct: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219

Query: 405 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 434
             ++  L        E+V ++ P                             S  D++FL
Sbjct: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279

Query: 435 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 493
            DGS ++  + F +V+ F+ +I+D L+V  +  ++ + QYS  V+ E       +K +I 
Sbjct: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339

Query: 494 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 553
             V+ M     K    G AL Y     F  S+G+R   G  +  ++   GRS D ++  A
Sbjct: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396

Query: 554 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
              K  G   F     NA   EL +I   P
Sbjct: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 58/167 (34%), Positives = 97/167 (58%), Gaps = 5/167 (2%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VFL+DGS ++   NF  ++ FI++++  L++   L QV + QY+ +VR EF      T
Sbjct: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           K+++  AVR M  ++   + TG+AL ++ +N FT S+G  A  G  K+ ++ T G+S D 
Sbjct: 335 KKDIKAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDY 391

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 202
           I+  A++ K      FA+G   A + EL EIA +  +   F  A+F+
Sbjct: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)

Query: 228 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 287
           S+  D++FL+DGS +V   NF  V+ F+  +V++LD+ +   +VGLVQ+S +   EF L 
Sbjct: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330

Query: 288 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 347
            + TK DI   +R +      G  TG+AL Y+  N FT + G+  R    ++ ++ T G+
Sbjct: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387

Query: 348 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 405
           S+D    AA      G   F VG   A + EL +IA  P     +   DF ++  + ++L
Sbjct: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447

Query: 406 IQPLTTYVSGGVEEVPLA 423
            + +       VEE P A
Sbjct: 448 QKKIC------VEEDPCA 459



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 50/170 (29%), Positives = 91/170 (53%), Gaps = 2/170 (1%)

Query: 21  PTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
           P    Q +  +      D+VF+VD S ++    F  ++ F+++VI+ L++G +  +V + 
Sbjct: 24  PGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMV 83

Query: 81  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRA-A 139
            YA TV+ EF    H +K  ++ AVR+++PL    + TG A+ F     F  + G R+ +
Sbjct: 84  NYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRS 142

Query: 140 EGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
             I K+++++T G+  D +   +   + S +  FAIG    D+A L +IA
Sbjct: 143 PDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIA 192



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 62/215 (28%), Positives = 108/215 (50%), Gaps = 16/215 (7%)

Query: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 845
           RV   T   L  L  +LQ L SPG+  +           D+VF++D S+S  P EF+ V+
Sbjct: 2   RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61

Query: 846 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 905
             + ++++ LDVG + TRV ++ ++   K EF L AH SK  +  AV+R++P     +  
Sbjct: 62  VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-T 120

Query: 906 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-A 963
           G A+++     F    G R     + + +++++ G+  D V D +   +  GV  F I  
Sbjct: 121 GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180

Query: 964 RNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 996
            + D+  L +I+  P  E+V  V ++  +  L +K
Sbjct: 181 GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRK 215


>gi|205277471 cochlin precursor [Homo sapiens]
          Length = 550

 Score =  138 bits (347), Expect = 3e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222

Query: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279

Query: 156 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 203
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339

Query: 204 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398

Query: 264 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457

Query: 324 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512

Query: 383 AFNP--SLVYLMDDFSSLPALPQQLIQ 407
           A  P  S  +   +F+ L  +   +I+
Sbjct: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539



 Score =  127 bits (318), Expect = 7e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 218 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 273
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206

Query: 274 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263

Query: 334 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 384
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323

Query: 385 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 441
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378

Query: 442 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 500
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438

Query: 501 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 560
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493

Query: 561 VVPFIFQAKNADPAELEQIVLSP 583
           +  F      A   +L+ +   P
Sbjct: 494 ITIFSVGVAWAPLDDLKDMASKP 516



 Score =  123 bits (308), Expect = 1e-27
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 595 IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 653
           +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 138 VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197

Query: 654 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 713
           G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256

Query: 714 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 770
              AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 257 TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314

Query: 771 ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 822
           ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 315 VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363

Query: 823 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
              ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 364 NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 941
           +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 424 YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478

Query: 942 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 994
            D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 479 YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 13/182 (7%)

Query: 8   PLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 67
           PLV   C        TH Q   +    N  +I FL+DGSS++G +NF  + +F++ + + 
Sbjct: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396

Query: 68  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 127
            EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F   
Sbjct: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVR 455

Query: 128 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 187
           N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L++
Sbjct: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511

Query: 188 IA 189
           +A
Sbjct: 512 MA 513


>gi|4758022 cochlin precursor [Homo sapiens]
          Length = 550

 Score =  138 bits (347), Expect = 3e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222

Query: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279

Query: 156 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 203
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339

Query: 204 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398

Query: 264 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457

Query: 324 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512

Query: 383 AFNP--SLVYLMDDFSSLPALPQQLIQ 407
           A  P  S  +   +F+ L  +   +I+
Sbjct: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539



 Score =  127 bits (318), Expect = 7e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 218 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 273
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206

Query: 274 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263

Query: 334 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 384
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323

Query: 385 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 441
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378

Query: 442 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 500
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438

Query: 501 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 560
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493

Query: 561 VVPFIFQAKNADPAELEQIVLSP 583
           +  F      A   +L+ +   P
Sbjct: 494 ITIFSVGVAWAPLDDLKDMASKP 516



 Score =  123 bits (308), Expect = 1e-27
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 595 IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 653
           +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 138 VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197

Query: 654 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 713
           G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256

Query: 714 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 770
              AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 257 TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314

Query: 771 ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 822
           ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 315 VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363

Query: 823 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
              ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 364 NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 941
           +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 424 YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478

Query: 942 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 994
            D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 479 YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 13/182 (7%)

Query: 8   PLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 67
           PLV   C        TH Q   +    N  +I FL+DGSS++G +NF  + +F++ + + 
Sbjct: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396

Query: 68  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 127
            EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F   
Sbjct: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVR 455

Query: 128 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 187
           N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L++
Sbjct: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511

Query: 188 IA 189
           +A
Sbjct: 512 MA 513


>gi|93141047 collagen, type XII, alpha 1 long isoform precursor [Homo
            sapiens]
          Length = 3063

 Score =  132 bits (332), Expect = 2e-30
 Identities = 89/280 (31%), Positives = 155/280 (55%), Gaps = 19/280 (6%)

Query: 762  NADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQP---- 815
            +A  TE      +P+  + V I ++ ++     VI     QLT +  S  +PV +     
Sbjct: 73   SASTTETLLSELVPETEYVVTITSYDEVEESVPVIG----QLTIQTGSSTKPVEKKPGKT 128

Query: 816  -LPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDP 873
             +    V    D+VFL+DGS S G   F+Y+   I  LV   D+G + TRV V+Q+S D 
Sbjct: 129  EIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDT 188

Query: 874  KVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFL 933
            + EF LN +  +DE+  A++++  KGG  +  G+A++Y+ +N F    G+R+  G P+  
Sbjct: 189  RTEFNLNQYYQRDELLAAIKKIPYKGGNTMT-GDAIDYLVKNTFTESAGARV--GFPKVA 245

Query: 934  VLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPE--YVFSVSTFREL 990
            ++I+ GKS DEV+ PA EL+  GV  F++  + AD +EL +I+ +P   +VF+V+ F  +
Sbjct: 246  IIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAI 305

Query: 991  PSLEQKLLTPITTLTSEQIQKLLASTR-YPPPGEMGASEV 1029
              ++ ++++ + +   EQ+ +L++      PP  + A EV
Sbjct: 306  VDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIAMEV 345



 Score =  128 bits (321), Expect = 3e-29
 Identities = 69/190 (36%), Positives = 118/190 (62%), Gaps = 9/190 (4%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++FL+DGS +VG+ NF Y+ DF+  LV++ DIG +  RVG+VQ+S    TEF+LN Y  
Sbjct: 140 DLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQ 199

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
           + ++L  ++++  +GG+ + TG A+ Y+  N FTE+ G+R+    P++ +++T G+S+D 
Sbjct: 200 RDELLAAIKKIPYKGGNTM-TGDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKSQDE 256

Query: 352 YLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL--VYLMDDFSSLPALPQQLIQPL 409
               A  L   G+  F +G   A+  EL+QIA  PSL  V+ + +F ++  +  ++I   
Sbjct: 257 VEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEII--- 313

Query: 410 TTYVSGGVEE 419
            + V  GV+E
Sbjct: 314 -SQVCSGVDE 322



 Score =  127 bits (320), Expect = 4e-29
 Identities = 76/194 (39%), Positives = 112/194 (57%), Gaps = 11/194 (5%)

Query: 18  SGFPTTHAQQQQAVIEVNK------RDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIG 71
           +G  T   +++    E+ K       D+VFLVDGS ++G  NF  I DFIA ++   +IG
Sbjct: 114 TGSSTKPVEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIG 173

Query: 72  QDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFT 131
           ++  +V V QY+   R EF  N +  + E++ A++K+ P  G    TG A+D++  N FT
Sbjct: 174 EEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAAIKKI-PYKGGNTMTGDAIDYLVKNTFT 232

Query: 132 SSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 191
            SAG R   G PK+ ++IT GKS DE+  PA+EL+   +  F++G K AD  EL++IA  
Sbjct: 233 ESAGARV--GFPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIAST 290

Query: 192 SSL--VFIPAEFRA 203
            SL  VF  A F A
Sbjct: 291 PSLNHVFNVANFDA 304



 Score =  119 bits (299), Expect = 1e-26
 Identities = 115/453 (25%), Positives = 219/453 (48%), Gaps = 33/453 (7%)

Query: 575  ELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGA------PAPVSGEKDVVFLLD 628
            E E +V   ++    ES+P IG L  Q  +  K V             VS   D+VFL+D
Sbjct: 87   ETEYVVTITSYDEVEESVPVIGQLTIQTGSSTKPVEKKPGKTEIQKCSVSAWTDLVFLVD 146

Query: 629  GSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNA 687
            GS  V R+ F  + +F+  +V + D+G+++ RV VVQYS  TR EF LN Y  + +++ A
Sbjct: 147  GSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAA 206

Query: 688  VRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVV 747
            ++++   GG T  TG A++++++N    SAG+R+  G P++ I++T  +S D+V  P+  
Sbjct: 207  IKKIPYKGGNT-MTGDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKSQDEVEIPARE 263

Query: 748  VKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQVISERVTQLTREE 805
            ++  G     +GI  AD  E++ I+  P  +    +  F  +  +Q  I  +V     E+
Sbjct: 264  LRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQ 323

Query: 806  LSRL---QPVLQPLPSPGVGGKRDVVFL-IDGSQSAGPEFQYVRTLIERLV----DYLDV 857
            L  L   + V++P PS  +  +    ++ ++ + S  P   Y   L           L V
Sbjct: 324  LGELVSGEEVVEP-PSNLIAMEVSSKYVKLNWNPSPSPVTGYKVILTPMTAGSRQHALSV 382

Query: 858  GFDTTRVAVIQFSDDPKVEFLLNAHS--SKDEVQNAVQRLRP-----KGGRQINVGNALE 910
            G  TT ++V   S D + +  ++A    +  E  + +++ +P     +  R +++   + 
Sbjct: 383  GPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECSRGVDIKADIV 442

Query: 911  YVSRNIFKRPLGSRIEEGVPQFL-VLISSGK-SDDEVDDPAVELKQFGVAPFTIARNADQ 968
            ++    +   + + ++  V  FL VL+ S + S + V    V+  +     FT+ +    
Sbjct: 443  FLVDGSYSIGIANFVK--VRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKV 500

Query: 969  EELVK-ISLSPEYVFSVSTFRELPSLEQKLLTP 1000
            E++++ I+  P    S +T + +  + +K+  P
Sbjct: 501  EDIIEAINTFPYRGGSTNTGKAMTYVREKIFVP 533



 Score =  119 bits (299), Expect = 1e-26
 Identities = 65/154 (42%), Positives = 95/154 (61%), Gaps = 3/154 (1%)

Query: 38   DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
            DIV LVDGS ++G ANF  +R FI+++++  +IG   +Q+A+AQY+   R E+  N H  
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258

Query: 98   KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
            K+ ++ AV  + P  G    TG AL+F+R   F + AG R      K+ VLIT GKS D+
Sbjct: 1259 KKSLLQAVANL-PYKGGNTLTGMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQDD 1315

Query: 158  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 191
            +  P+++LK   +  FAIG K AD+ EL+ IA D
Sbjct: 1316 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATD 1349



 Score =  112 bits (281), Expect = 1e-24
 Identities = 66/182 (36%), Positives = 106/182 (58%), Gaps = 5/182 (2%)

Query: 230 KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 289
           K DI+FL+DGS ++G  NF  VR F+  LV S +I  + +++ LVQ+S  P TEF+L  +
Sbjct: 438 KADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKF 497

Query: 290 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349
               DI+  +     +GGS  NTG A++YV    F  + GS  R +VP++++L+T G+S 
Sbjct: 498 TKVEDIIEAINTFPYRGGS-TNTGKAMTYVREKIFVPSKGS--RSNVPKVMILITDGKSS 554

Query: 350 DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQ 407
           D++   A  L  + +  F VG   A ++ELE IA  P  + V+ ++DF +   +  +L Q
Sbjct: 555 DAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQ 614

Query: 408 PL 409
            +
Sbjct: 615 SI 616



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/154 (38%), Positives = 91/154 (59%), Gaps = 3/154 (1%)

Query: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95
           K DIVFLVDGS ++G+ANF  +R F+  +++  EI  + +Q+++ QY+     EF     
Sbjct: 438 KADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKF 497

Query: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155
               ++I A+    P  G +  TG A+ +VR  +F  S G R+   +PK+++LIT GKS 
Sbjct: 498 TKVEDIIEAINTF-PYRGGSTNTGKAMTYVREKIFVPSKGSRS--NVPKVMILITDGKSS 554

Query: 156 DEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           D    PA +L+ S +  FA+G K A ++ELE IA
Sbjct: 555 DAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIA 588



 Score =  109 bits (272), Expect = 2e-23
 Identities = 67/180 (37%), Positives = 103/180 (57%), Gaps = 6/180 (3%)

Query: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 288
            K DI+FL D S ++G  NF  V  F+ N V   D I    I+V  VQ+SD   +EF LNT
Sbjct: 2321 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 2380

Query: 289  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 348
            Y  K+  LG L+ ++ +GG+   TG AL+++     T   G  +R++VP++L+++T G+S
Sbjct: 2381 YNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESG--MRKNVPKVLVVVTDGRS 2437

Query: 349  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLI 406
            +D   +AA  + ++G   F VG +  +  EL  IA  PS   V+++DDF S   +   LI
Sbjct: 2438 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLI 2497



 Score =  106 bits (265), Expect = 1e-22
 Identities = 79/250 (31%), Positives = 122/250 (48%), Gaps = 13/250 (5%)

Query: 789  TVQQVISERVTQLTREELSRLQPVLQPLP-----SPGVGGKRDVVFLIDGSQSAG-PEFQ 842
            T  Q+    +  +T  E   +    QP+      S GV  K D+VFL+DGS S G   F 
Sbjct: 398  TEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFV 457

Query: 843  YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 902
             VR  +E LV   ++  +  +++++Q+S DP  EF L   +  +++  A+     +GG  
Sbjct: 458  KVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGG-S 516

Query: 903  INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 962
             N G A+ YV   IF    GSR    VP+ ++LI+ GKS D   DPA++L+   V  F +
Sbjct: 517  TNTGKAMTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAV 574

Query: 963  -ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYP 1019
              ++A + EL  I+  P   +VF+V  F     +  + LT    L  EQ    +    Y 
Sbjct: 575  GVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFE-LTQSICLRIEQELAAIKKKAYV 633

Query: 1020 PPGEMGASEV 1029
            PP ++  SEV
Sbjct: 634  PPKDLSFSEV 643



 Score =  103 bits (257), Expect = 8e-22
 Identities = 71/206 (34%), Positives = 112/206 (54%), Gaps = 12/206 (5%)

Query: 801  LTREELSRLQPV-LQPLPSPGVG----GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDY 854
            L  +E++ L    + P+ S G+      + D+V L+DGS S G   F+ VR+ I R+V+ 
Sbjct: 1169 LVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEV 1228

Query: 855  LDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSR 914
             D+G    ++A+ Q+S DP+ E+ LNAH  K  +  AV  L  KGG  +  G AL ++ +
Sbjct: 1229 FDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTL-TGMALNFIRQ 1287

Query: 915  NIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVK 973
              F+   G R      +  VLI+ GKS D+V+ P+ +LK  GV  F I  +NAD+ EL  
Sbjct: 1288 QNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKM 1345

Query: 974  ISLSPE--YVFSVSTFRELPSLEQKL 997
            I+  P+  + ++V+ F  L  +   L
Sbjct: 1346 IATDPDDTHAYNVADFESLSRIVDDL 1371



 Score =  103 bits (256), Expect = 1e-21
 Identities = 62/186 (33%), Positives = 100/186 (53%), Gaps = 5/186 (2%)

Query: 232  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
            DI+ L+DGS ++G+ NF  VR F+  +V   DIG   +++ L Q+S  P TE+ LN ++ 
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258

Query: 292  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
            K  +L  +  L  +GG+ L TG AL+++   +F    G R R    ++ +L+T G+S+D 
Sbjct: 1259 KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMRPRAR--KIGVLITDGKSQDD 1315

Query: 352  YLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPL 409
                +  L   G+  F +G   A++ EL+ IA +P  +  Y + DF SL  +   L   L
Sbjct: 1316 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINL 1375

Query: 410  TTYVSG 415
               V G
Sbjct: 1376 CNSVKG 1381



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 64/190 (33%), Positives = 102/190 (53%), Gaps = 6/190 (3%)

Query: 590  ESLPKIGDLHPQI--VNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQR 646
            ES P +G     +    ++  + +G       E D+V L+DGS  + R+ F  ++ F+ R
Sbjct: 1165 ESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISR 1224

Query: 647  VVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALE 706
            +VE  D+G  RV++A+ QYS   R E+ LN++ +K+ ++ AV  L   GG T  TG AL 
Sbjct: 1225 IVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNT-LTGMALN 1283

Query: 707  FVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADIT 766
            F+ +    + AG R      ++ +++T  +S DDV  PS  +K  G     IGI NAD  
Sbjct: 1284 FIRQQNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEV 1341

Query: 767  EMQTISFIPD 776
            E++ I+  PD
Sbjct: 1342 ELKMIATDPD 1351



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 62/212 (29%), Positives = 108/212 (50%), Gaps = 7/212 (3%)

Query: 416 GVEEVPLAQPESKRDILFLFDGSANLV-GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 474
           G  E+      +  D++FL DGS ++    F  + DF+  ++   ++  E TR+ V QYS
Sbjct: 126 GKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYS 185

Query: 475 DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 534
            D + E   +++  + E+L  +K++  K G  +  G A+DY  +  F +SAG+R+  G  
Sbjct: 186 SDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMT-GDAIDYLVKNTFTESAGARV--GFP 242

Query: 535 QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAF--ILAAESL 592
           +  +++  G+S D V+ PA  L+  GV  F    K AD  EL+QI  +P+   +    + 
Sbjct: 243 KVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANF 302

Query: 593 PKIGDLHPQIVN-LLKSVHNGAPAPVSGEKDV 623
             I D+  +I++ +   V       VSGE+ V
Sbjct: 303 DAIVDIQNEIISQVCSGVDEQLGELVSGEEVV 334



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 61/171 (35%), Positives = 93/171 (54%), Gaps = 6/171 (3%)

Query: 36   KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVAVAQYADTVRPEFYFNT 94
            K DIVFL D S ++G  NFN +  FI   +    EI    IQV+  QY+D V+ EF  NT
Sbjct: 2321 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 2380

Query: 95   HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 154
            +  K   + A++ ++   G+   TG AL F++  + T  +G R  + +PK+LV++T G+S
Sbjct: 2381 YNDKALALGALQNIRYRGGNTR-TGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGRS 2437

Query: 155  LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS--LVFIPAEFRA 203
             DE+ + A  +++S    F +G    D  EL  IA   S   VFI  +F +
Sbjct: 2438 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFES 2488



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 49/155 (31%), Positives = 91/155 (58%), Gaps = 4/155 (2%)

Query: 622 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D+VFL+DGS  +  + F  ++ F++ +V+S ++  +RV++++VQYS     EF L  +  
Sbjct: 440 DIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTK 499

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 740
            +D++ A+      GG T NTG A+ +V   I V S GSR    VP+++I++T  +S D 
Sbjct: 500 VEDIIEAINTFPYRGGST-NTGKAMTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDA 556

Query: 741 VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
            R+P++ ++        +G+ +A  +E++ I+  P
Sbjct: 557 FRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPP 591



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 32/296 (10%)

Query: 391  LMDDFSSLPALPQQLIQPLTTYV----SGGVEEVPLAQPESKRDILFLFDGSANLV-GQF 445
            + D   S P + Q++     T V    S G+E +  A+     DI+ L DGS ++    F
Sbjct: 1160 MFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEA----DIVLLVDGSWSIGRANF 1215

Query: 446  PVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGK 505
              VR F+ +I++  ++ P+  +IA+AQYS D + E + + H+ K  +L  V  +  K G 
Sbjct: 1216 RTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGN 1275

Query: 506  ALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFI 565
             L  G AL++ ++  F   AG R      +  VL+  G+S D V+ P+  LK  GV  F 
Sbjct: 1276 TLT-GMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFA 1332

Query: 566  FQAKNADPAELEQIVLSP----AFILA-AESLPKIGDLHPQIVNLLKSVHNGAPAPVSGE 620
               KNAD  EL+ I   P    A+ +A  ESL +I D     +NL  SV    P  +   
Sbjct: 1333 IGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVD--DLTINLCNSVK--GPGDLEAP 1388

Query: 621  KDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
             ++V         R  +    + V           DR +V     S   R EFY++
Sbjct: 1389 SNLVISERTHRSFRVSWTPPSDSV-----------DRYKVEYYPVSGGKRQEFYVS 1433



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 63/217 (29%), Positives = 105/217 (48%), Gaps = 9/217 (4%)

Query: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF--QYVRTLIERLVDYLDVGFDTTRVAVIQ 868
            P + P      G K D+VFL D S S G +   + V+ +   +  + ++     +V+ +Q
Sbjct: 2308 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 2367

Query: 869  FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 928
            +SD+ K EF LN ++ K     A+Q +R +GG     G AL ++   +     G R  + 
Sbjct: 2368 YSDEVKSEFKLNTYNDKALALGALQNIRYRGG-NTRTGKALTFIKEKVLTWESGMR--KN 2424

Query: 929  VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVS 985
            VP+ LV+++ G+S DEV   A+ ++Q G + F +   + D  EL  I+  P   +VF V 
Sbjct: 2425 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 2484

Query: 986  TFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG 1022
             F     +E  L+T +   T+     L+    Y  PG
Sbjct: 2485 DFESFEKIEDNLITFVCE-TATSSCPLIYLDGYTSPG 2520



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 11/178 (6%)

Query: 600  PQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLD-VGQDR 657
            P  +   + V  GA A      D+VFL D S  +    F  + +F+   V   D +    
Sbjct: 2307 PPTIPPARDVCKGAKA------DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 2360

Query: 658  VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 717
            ++V+ VQYSD  + EF LN+Y +K   + A++ +   GG T  TG AL F+   +L   +
Sbjct: 2361 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWES 2419

Query: 718  GSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
            G R  + VP++L+V+T  RS D+V+  ++V+++ G     +G+ + D  E+  I+  P
Sbjct: 2420 GMR--KNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKP 2475



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 62/192 (32%), Positives = 90/192 (46%), Gaps = 14/192 (7%)

Query: 396 SSLPALPQQLIQPLTTYV--SGGVEEVPLAQPESKRDILFLFDGSANL-VGQFPVVRDFL 452
           SS P    +  QP+   V  S GV+         K DI+FL DGS ++ +  F  VR FL
Sbjct: 412 SSEPISIMEKTQPMKVQVECSRGVD--------IKADIVFLVDGSYSIGIANFVKVRAFL 463

Query: 453 YKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYA 512
             ++    + P   +I++ QYS D   E    +     +I+  +     + G   N G A
Sbjct: 464 EVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGST-NTGKA 522

Query: 513 LDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNAD 572
           + Y +  IFV S GSR    V + ++L+  G+SSD    PA  L+ S V  F    K+A 
Sbjct: 523 MTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAV 580

Query: 573 PAELEQIVLSPA 584
            +ELE I   PA
Sbjct: 581 RSELEAIASPPA 592



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 10/178 (5%)

Query: 427  SKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFD 484
            +K DI+FL D S ++    F  V  F++  +   + + P G +++  QYSD+VK E + +
Sbjct: 2320 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 2379

Query: 485  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 544
             +  K   L  ++ ++ + G     G AL + +  +    +G R    V + LV++  GR
Sbjct: 2380 TYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGR 2436

Query: 545  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA----FIL-AAESLPKIGD 597
            S D V   A  ++QSG   F+    + D  EL  I   P+    FI+   ES  KI D
Sbjct: 2437 SQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIED 2494


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score =  129 bits (324), Expect = 1e-29
 Identities = 90/254 (35%), Positives = 138/254 (54%), Gaps = 29/254 (11%)

Query: 221 SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTP 280
           +G   VH    D++FLLD S++VGK +F  VR +V NLV++ ++G D  RVG+V++SD P
Sbjct: 30  AGCKSVHY---DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRP 86

Query: 281 VTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV-PQL 339
            T F L  + ++ ++    R+L   GG+  NTG AL Y+ A  F+   G R R+    Q+
Sbjct: 87  TTAFELGLFGSQEEVKAAARRLAYHGGN-TNTGDALRYITARSFSPHAGGRPRDRAYKQV 145

Query: 340 LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSS 397
            +LLT G+S+D  L AA A  RAGI  F VG  +A K ELE+IA  P  + V+ + DF++
Sbjct: 146 AILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNA 205

Query: 398 LPALPQQLIQPLT---------------TYVSGGVEEV---PLAQPESKRDILFLFDGSA 439
           +  +  +L + L                 + +GG +E+    L    S ++IL   +  A
Sbjct: 206 IDKIRGKLRRRLCENVLCPSVRVEGDRFKHTNGGTKEITGFDLMDLFSVKEILGKRENGA 265

Query: 440 N----LVGQFPVVR 449
                 +G FPVV+
Sbjct: 266 QSSYVRMGSFPVVQ 279



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 66/177 (37%), Positives = 96/177 (54%), Gaps = 6/177 (3%)

Query: 826 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D+VFL+D S S G E F+ VR  +  LVD  +VG D TRV V+++SD P   F L    S
Sbjct: 38  DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGKSDD 943
           ++EV+ A +RL   GG   N G+AL Y++   F    G R  +    Q  +L++ G+S D
Sbjct: 98  QEEVKAAARRLAYHGG-NTNTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQD 156

Query: 944 EVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFRELPSLEQKL 997
            V D A    + G+  F +    A +EEL +I+  P+  +VF VS F  +  +  KL
Sbjct: 157 LVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNAIDKIRGKL 213



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 64/180 (35%), Positives = 94/180 (52%), Gaps = 7/180 (3%)

Query: 605 LLKSVHNGAPAPVSGEK----DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVR 659
           LL S   G  A  +G K    D+VFLLD S  V +  F  ++++V  +V++ +VG DR R
Sbjct: 17  LLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTR 76

Query: 660 VAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGS 719
           V VV+YSDR    F L  + ++++V  A R+L   GG T NTG AL ++        AG 
Sbjct: 77  VGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNT-NTGDALRYITARSFSPHAGG 135

Query: 720 RITE-GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFA 778
           R  +    Q+ I+LT  RS D V + +    R G     +G+G A   E++ I+  P  A
Sbjct: 136 RPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSA 195



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 65/213 (30%), Positives = 107/213 (50%), Gaps = 10/213 (4%)

Query: 26  QQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADT 85
           Q Q+A  +    D+VFL+D SS++G  +F  +R ++A ++   E+G D  +V V +Y+D 
Sbjct: 26  QAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDR 85

Query: 86  VRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE-GIPK 144
               F      ++ EV  A R++    G    TG AL ++    F+  AG R  +    +
Sbjct: 86  PTTAFELGLFGSQEEVKAAARRL-AYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQ 144

Query: 145 LLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 202
           + +L+T G+S D +   A    R+ I  FA+G   A + ELEEIA +  S+ VF  ++F 
Sbjct: 145 VAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFN 204

Query: 203 AA-PLQGML-----PGLLAPLRTLSGTPEVHSN 229
           A   ++G L       +L P   + G    H+N
Sbjct: 205 AIDKIRGKLRRRLCENVLCPSVRVEGDRFKHTN 237



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)

Query: 430 DILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
           D++FL D S+++  + F  VR ++  ++D   V P+ TR+ V +YSD            S
Sbjct: 38  DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97

Query: 489 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAGRSSD 547
           + E+    +R+    G   N G AL Y     F   AG R  D    Q  +LL  GRS D
Sbjct: 98  QEEVKAAARRLAYHGGNT-NTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQD 156

Query: 548 RVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
            V   A+   ++G+  F      A   ELE+I   P
Sbjct: 157 LVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEP 192


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score =  129 bits (323), Expect = 2e-29
 Identities = 84/217 (38%), Positives = 127/217 (58%), Gaps = 9/217 (4%)

Query: 826  DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
            D+V L+DGS S G   F+ VR  +E LV   DVG + TR+ + Q+S DP++E+ LNA S+
Sbjct: 158  DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 885  KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 944
            KDEV  AV+ L  KGG  +  G AL Y+  N FK   GSR   GV +  +LI+ GKS D+
Sbjct: 218  KDEVIEAVRNLPYKGGNTL-TGLALNYIFENSFKPEAGSR--TGVSKIGILITDGKSQDD 274

Query: 945  VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFRELPSLEQKLLTPI 1001
            +  P+  L++ GV  F I  +NAD  EL +I+  P+  +V++V+ F  + ++ + L   +
Sbjct: 275  IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTL 334

Query: 1002 TTLTSEQIQKLLASTR--YPPPGEMGASEVLLGAFSI 1036
             +   EQ +++ AS      PP E+  SEV   +F +
Sbjct: 335  CSRVEEQDREIKASAHAITGPPTELITSEVTARSFMV 371



 Score =  119 bits (297), Expect = 2e-26
 Identities = 88/296 (29%), Positives = 149/296 (50%), Gaps = 36/296 (12%)

Query: 144 KLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAE--F 201
           KLLV  T G   ++++     L+ ++  A   G        ++ IA++      PA+  F
Sbjct: 61  KLLVTPTSGGKTNQLN-----LQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQF 115

Query: 202 RAAPLQ----------------GMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGK 245
           R   L+                G  P     ++ +  TP +     DI+ L+DGS ++G+
Sbjct: 116 RIKDLEKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAI----ADIVILVDGSWSIGR 171

Query: 246 TNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQ 305
            NF  VR F+ NLV + D+G++  R+GL Q+S  P  E+ LN + TK +++  +R L  +
Sbjct: 172 FNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYK 231

Query: 306 GGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGIL 365
           GG+ L TG AL+Y++ N F    GS  R  V ++ +L+T G+S+D  +  +  L  +G+ 
Sbjct: 232 GGNTL-TGLALNYIFENSFKPEAGS--RTGVSKIGILITDGKSQDDIIPPSRNLRESGVE 288

Query: 366 TFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEE 419
            F +G   A+  EL++IA  P  + VY + +F     L   +++ LT  +   VEE
Sbjct: 289 LFAIGVKNADVNELQEIASEPDSTHVYNVAEFD----LMHTVVESLTRTLCSRVEE 340



 Score =  119 bits (297), Expect = 2e-26
 Identities = 70/166 (42%), Positives = 100/166 (60%), Gaps = 5/166 (3%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           DIV LVDGS ++G  NF  +R F+  ++   ++G +  ++ +AQY+   R E++ N   T
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           K EVI AVR + P  G    TG AL+++  N F   AG R   G+ K+ +LIT GKS D+
Sbjct: 218 KDEVIEAVRNL-PYKGGNTLTGLALNYIFENSFKPEAGSRT--GVSKIGILITDGKSQDD 274

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAF--DSSLVFIPAEF 201
           I  P++ L+ S +  FAIG K AD  EL+EIA   DS+ V+  AEF
Sbjct: 275 IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEF 320



 Score =  112 bits (280), Expect = 2e-24
 Identities = 61/180 (33%), Positives = 105/180 (58%), Gaps = 6/180 (3%)

Query: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 288
            K D++F++DGS ++G  NF  +  F+ + V +L+ IG D  +V +VQF+D P TEF LN 
Sbjct: 1030 KADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNA 1089

Query: 289  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 348
            Y+TK  +L  ++ +  +GG+   TG A+ YV    FT   G+  R  +P++++++T G+S
Sbjct: 1090 YKTKETLLDAIKHISYKGGN-TKTGKAIKYVRDTLFTAESGT--RRGIPKVIVVITDGRS 1146

Query: 349  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL--VYLMDDFSSLPALPQQLI 406
            +D   + +  +   G   F +G + A+ +EL  I   PS   V+ +DDF +   +  +LI
Sbjct: 1147 QDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELI 1206



 Score =  110 bits (275), Expect = 7e-24
 Identities = 75/232 (32%), Positives = 122/232 (52%), Gaps = 10/232 (4%)

Query: 775  PDFAVAIPTFRQLGTVQ--QVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLID 832
            PD    I  + +L  ++   V     TQ          P + P        K D+VF++D
Sbjct: 979  PDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIPPAKEVCKAAKADLVFMVD 1038

Query: 833  GSQSAGPE-FQYVRTLIERLVDYLD-VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQN 890
            GS S G E F  + + +   V  L+ +G D T+VA++QF+DDP+ EF LNA+ +K+ + +
Sbjct: 1039 GSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLD 1098

Query: 891  AVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAV 950
            A++ +  KGG     G A++YV   +F    G+R   G+P+ +V+I+ G+S D+V+  + 
Sbjct: 1099 AIKHISYKGG-NTKTGKAIKYVRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISR 1155

Query: 951  ELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKLLT 999
            E++  G + F I   +AD  ELV I   P   +VF V  F     +E +L+T
Sbjct: 1156 EMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELIT 1207



 Score =  108 bits (271), Expect = 2e-23
 Identities = 70/187 (37%), Positives = 108/187 (57%), Gaps = 7/187 (3%)

Query: 20   FPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVA 78
            FP T    ++ V +  K D+VF+VDGS ++G  NFN I  F+   +  L +IG D  QVA
Sbjct: 1015 FPPTIPPAKE-VCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVA 1073

Query: 79   VAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRA 138
            + Q+ D  R EF  N + TK  ++ A++ +    G+   TG A+ +VR+ LFT+ +G R 
Sbjct: 1074 MVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTK-TGKAIKYVRDTLFTAESGTR- 1131

Query: 139  AEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL--VF 196
              GIPK++V+IT G+S D++++ ++E++      FAIG   AD +EL  I    S   VF
Sbjct: 1132 -RGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVF 1190

Query: 197  IPAEFRA 203
               +F A
Sbjct: 1191 FVDDFDA 1197



 Score =  107 bits (266), Expect = 8e-23
 Identities = 69/192 (35%), Positives = 106/192 (55%), Gaps = 13/192 (6%)

Query: 622 DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D+V L+DGS  + R  F L++ F++ +V + DVG ++ R+ + QYS   R E++LN++  
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 740
           K +V+ AVR L   GG T  TG AL ++  N     AGSR   GV ++ I++T  +S DD
Sbjct: 218 KDEVIEAVRNLPYKGGNT-LTGLALNYIFENSFKPEAGSR--TGVSKIGILITDGKSQDD 274

Query: 741 VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISERV 798
           +  PS  ++  G     IG+ NAD+ E+Q I+  PD      +  F  + TV       V
Sbjct: 275 IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTV-------V 327

Query: 799 TQLTREELSRLQ 810
             LTR   SR++
Sbjct: 328 ESLTRTLCSRVE 339



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 62/168 (36%), Positives = 91/168 (54%), Gaps = 5/168 (2%)

Query: 418 EEVP-LAQPESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSD 475
           EEV  + Q  +  DI+ L DGS ++    F +VR FL  ++   +V  E TRI +AQYS 
Sbjct: 145 EEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSG 204

Query: 476 DVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQ 535
           D ++E   +   +K E++  V+ +  K G  L  G AL+Y     F   AGSR   GV +
Sbjct: 205 DPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLT-GLALNYIFENSFKPEAGSR--TGVSK 261

Query: 536 FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
             +L+  G+S D +  P+ NL++SGV  F    KNAD  EL++I   P
Sbjct: 262 IGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEP 309



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 60/188 (31%), Positives = 104/188 (55%), Gaps = 11/188 (5%)

Query: 590  ESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVV 648
            +SLP      P  +   K V   A A      D+VF++DGS  +    F  +  F+   V
Sbjct: 1006 QSLPTRPPTFPPTIPPAKEVCKAAKA------DLVFMVDGSWSIGDENFNKIISFLYSTV 1059

Query: 649  ESLD-VGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEF 707
             +L+ +G D  +VA+VQ++D  R EF LN+Y  K+ +++A++ ++  GG T  TG A+++
Sbjct: 1060 GALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNT-KTGKAIKY 1118

Query: 708  VLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITE 767
            V   +  + +G+R   G+P++++V+T  RS DDV   S  ++  G     IG+ +AD +E
Sbjct: 1119 VRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSE 1176

Query: 768  MQTISFIP 775
            + +I   P
Sbjct: 1177 LVSIGSKP 1184



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 55/198 (27%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 389  VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPV 447
            V +M+   SLP  P     P         +EV  A   +K D++F+ DGS ++  + F  
Sbjct: 999  VSIMEKTQSLPTRP-----PTFPPTIPPAKEVCKA---AKADLVFMVDGSWSIGDENFNK 1050

Query: 448  VRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKA 506
            +  FLY  +  LN +  +GT++A+ Q++DD + E + + +++K  +L+ +K +  K G  
Sbjct: 1051 IISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNT 1110

Query: 507  LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIF 566
               G A+ Y +  +F   +G+R   G+ + +V++  GRS D V+  +  ++  G   F  
Sbjct: 1111 -KTGKAIKYVRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAI 1167

Query: 567  QAKNADPAELEQIVLSPA 584
               +AD +EL  I   P+
Sbjct: 1168 GVADADYSELVSIGSKPS 1185


>gi|93141049 collagen, type XII, alpha 1 short isoform precursor
           [Homo sapiens]
          Length = 1899

 Score =  119 bits (299), Expect = 1e-26
 Identities = 65/154 (42%), Positives = 95/154 (61%), Gaps = 3/154 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           DIV LVDGS ++G ANF  +R FI+++++  +IG   +Q+A+AQY+   R E+  N H  
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           K+ ++ AV  + P  G    TG AL+F+R   F + AG R      K+ VLIT GKS D+
Sbjct: 95  KKSLLQAVANL-PYKGGNTLTGMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQDD 151

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 191
           +  P+++LK   +  FAIG K AD+ EL+ IA D
Sbjct: 152 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATD 185



 Score =  109 bits (272), Expect = 2e-23
 Identities = 67/180 (37%), Positives = 103/180 (57%), Gaps = 6/180 (3%)

Query: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 288
            K DI+FL D S ++G  NF  V  F+ N V   D I    I+V  VQ+SD   +EF LNT
Sbjct: 1157 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 1216

Query: 289  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 348
            Y  K+  LG L+ ++ +GG+   TG AL+++     T   G  +R++VP++L+++T G+S
Sbjct: 1217 YNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESG--MRKNVPKVLVVVTDGRS 1273

Query: 349  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLI 406
            +D   +AA  + ++G   F VG +  +  EL  IA  PS   V+++DDF S   +   LI
Sbjct: 1274 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLI 1333



 Score =  103 bits (256), Expect = 1e-21
 Identities = 62/186 (33%), Positives = 100/186 (53%), Gaps = 5/186 (2%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           DI+ L+DGS ++G+ NF  VR F+  +V   DIG   +++ L Q+S  P TE+ LN ++ 
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
           K  +L  +  L  +GG+ L TG AL+++   +F    G R R    ++ +L+T G+S+D 
Sbjct: 95  KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMRPRAR--KIGVLITDGKSQDD 151

Query: 352 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPL 409
               +  L   G+  F +G   A++ EL+ IA +P  +  Y + DF SL  +   L   L
Sbjct: 152 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINL 211

Query: 410 TTYVSG 415
              V G
Sbjct: 212 CNSVKG 217



 Score =  102 bits (255), Expect = 1e-21
 Identities = 65/176 (36%), Positives = 99/176 (56%), Gaps = 7/176 (3%)

Query: 826 DVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D+V L+DGS S G   F+ VR+ I R+V+  D+G    ++A+ Q+S DP+ E+ LNAH  
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 944
           K  +  AV  L  KGG  +  G AL ++ +  F+   G R      +  VLI+ GKS D+
Sbjct: 95  KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKSQDD 151

Query: 945 VDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPE--YVFSVSTFRELPSLEQKL 997
           V+ P+ +LK  GV  F I  +NAD+ EL  I+  P+  + ++V+ F  L  +   L
Sbjct: 152 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 207



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 63/174 (36%), Positives = 96/174 (55%), Gaps = 5/174 (2%)

Query: 605 LLKSVH-NGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAV 662
           LL S+   G       E D+V L+DGS  + R+ F  ++ F+ R+VE  D+G  RV++A+
Sbjct: 17  LLSSIEAEGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIAL 76

Query: 663 VQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRIT 722
            QYS   R E+ LN++ +K+ ++ AV  L   GG T  TG AL F+ +    + AG R  
Sbjct: 77  AQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNT-LTGMALNFIRQQNFRTQAGMR-- 133

Query: 723 EGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPD 776
               ++ +++T  +S DDV  PS  +K  G     IGI NAD  E++ I+  PD
Sbjct: 134 PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPD 187



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 61/171 (35%), Positives = 93/171 (54%), Gaps = 6/171 (3%)

Query: 36   KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVAVAQYADTVRPEFYFNT 94
            K DIVFL D S ++G  NFN +  FI   +    EI    IQV+  QY+D V+ EF  NT
Sbjct: 1157 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 1216

Query: 95   HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 154
            +  K   + A++ ++   G+   TG AL F++  + T  +G R  + +PK+LV++T G+S
Sbjct: 1217 YNDKALALGALQNIRYRGGNTR-TGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGRS 1273

Query: 155  LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS--LVFIPAEFRA 203
             DE+ + A  +++S    F +G    D  EL  IA   S   VFI  +F +
Sbjct: 1274 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFES 1324



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 77/256 (30%), Positives = 119/256 (46%), Gaps = 24/256 (9%)

Query: 427 SKRDILFLFDGSANLV-GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDE 485
           ++ DI+ L DGS ++    F  VR F+ +I++  ++ P+  +IA+AQYS D + E + + 
Sbjct: 32  AEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNA 91

Query: 486 HQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS 545
           H+ K  +L  V  +  K G  L  G AL++ ++  F   AG R      +  VL+  G+S
Sbjct: 92  HRDKKSLLQAVANLPYKGGNTLT-GMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKS 148

Query: 546 SDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----AFILA-AESLPKIGDLHP 600
            D V+ P+  LK  GV  F    KNAD  EL+ I   P    A+ +A  ESL +I D   
Sbjct: 149 QDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVD--D 206

Query: 601 QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 660
             +NL  SV    P  +    ++V         R  +    + V           DR +V
Sbjct: 207 LTINLCNSVK--GPGDLEAPSNLVISERTHRSFRVSWTPPSDSV-----------DRYKV 253

Query: 661 AVVQYSDRTRPEFYLN 676
                S   R EFY++
Sbjct: 254 EYYPVSGGKRQEFYVS 269



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 63/217 (29%), Positives = 105/217 (48%), Gaps = 9/217 (4%)

Query: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF--QYVRTLIERLVDYLDVGFDTTRVAVIQ 868
            P + P      G K D+VFL D S S G +   + V+ +   +  + ++     +V+ +Q
Sbjct: 1144 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 1203

Query: 869  FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 928
            +SD+ K EF LN ++ K     A+Q +R +GG     G AL ++   +     G R  + 
Sbjct: 1204 YSDEVKSEFKLNTYNDKALALGALQNIRYRGG-NTRTGKALTFIKEKVLTWESGMR--KN 1260

Query: 929  VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVS 985
            VP+ LV+++ G+S DEV   A+ ++Q G + F +   + D  EL  I+  P   +VF V 
Sbjct: 1261 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 1320

Query: 986  TFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG 1022
             F     +E  L+T +   T+     L+    Y  PG
Sbjct: 1321 DFESFEKIEDNLITFVCE-TATSSCPLIYLDGYTSPG 1356



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 11/178 (6%)

Query: 600  PQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLD-VGQDR 657
            P  +   + V  GA A      D+VFL D S  +    F  + +F+   V   D +    
Sbjct: 1143 PPTIPPARDVCKGAKA------DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 1196

Query: 658  VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 717
            ++V+ VQYSD  + EF LN+Y +K   + A++ +   GG T  TG AL F+   +L   +
Sbjct: 1197 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWES 1255

Query: 718  GSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
            G R  + VP++L+V+T  RS D+V+  ++V+++ G     +G+ + D  E+  I+  P
Sbjct: 1256 GMR--KNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKP 1311



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 10/178 (5%)

Query: 427  SKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFD 484
            +K DI+FL D S ++    F  V  F++  +   + + P G +++  QYSD+VK E + +
Sbjct: 1156 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 1215

Query: 485  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 544
             +  K   L  ++ ++ + G     G AL + +  +    +G R    V + LV++  GR
Sbjct: 1216 TYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGR 1272

Query: 545  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA----FIL-AAESLPKIGD 597
            S D V   A  ++QSG   F+    + D  EL  I   P+    FI+   ES  KI D
Sbjct: 1273 SQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIED 1330


>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
          Length = 1284

 Score =  111 bits (277), Expect = 4e-24
 Identities = 68/197 (34%), Positives = 113/197 (57%), Gaps = 6/197 (3%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++FL+DGS ++G ++F  V+DF+ +++   +IG D ++VGL Q+S    TE+ LN+  T
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
           K  +L  +R+L+ +GG+   TG AL++V   +   A G  +R    ++++L+T G+S+D 
Sbjct: 239 KEQVLAAVRRLRYKGGNTF-TGLALTHVLGQNLQPAAG--LRPEAAKVVILVTDGKSQDD 295

Query: 352 YLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLIQPL 409
              AA  L   G+  F VG   A++AEL  +A  P    V+ + DF  L AL   L + +
Sbjct: 296 VHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLI 355

Query: 410 TTYVSGG-VEEVPLAQP 425
              + GG   + P A P
Sbjct: 356 CQRLQGGSPRQGPAAAP 372



 Score =  110 bits (276), Expect = 5e-24
 Identities = 74/207 (35%), Positives = 112/207 (54%), Gaps = 7/207 (3%)

Query: 21  PTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
           P T A  Q   +     D+VFLVDGS ++G ++F  ++DF+A VI   EIG D +QV + 
Sbjct: 162 PRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLT 221

Query: 81  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 140
           QY+   + E+  N+  TK +V+ AVR+++   G   +TG AL  V       +AG R   
Sbjct: 222 QYSGDAQTEWDLNSLSTKEQVLAAVRRLR-YKGGNTFTGLALTHVLGQNLQPAAGLRPEA 280

Query: 141 GIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAE 200
              K+++L+T GKS D++   A+ LK   +  FA+G K AD+AEL  +A     + + + 
Sbjct: 281 A--KVVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSV 338

Query: 201 FRAAPLQGMLPGLLAPL---RTLSGTP 224
                L G L GLL+ L   R   G+P
Sbjct: 339 LDFLQL-GALAGLLSRLICQRLQGGSP 364



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/205 (34%), Positives = 111/205 (54%), Gaps = 10/205 (4%)

Query: 622 DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D+VFL+DGS  +  S F  +K+F+  V+   ++G D+V+V + QYS   + E+ LNS   
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 740
           K+ V+ AVR+L   GG T  TG AL  VL   L  +AG R      +++I++T  +S DD
Sbjct: 239 KEQVLAAVRRLRYKGGNT-FTGLALTHVLGQNLQPAAGLR--PEAAKVVILVTDGKSQDD 295

Query: 741 VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-DFAV-AIPTFRQLGTVQQVISERV 798
           V   + V+K  G     +G+ NAD  E++ ++  P D  V ++  F QLG +  ++S  +
Sbjct: 296 VHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLI 355

Query: 799 TQLTREELSR----LQPVLQPLPSP 819
            Q  +    R      P L  LP+P
Sbjct: 356 CQRLQGGSPRQGPAAAPALDTLPAP 380



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 66/185 (35%), Positives = 101/185 (54%), Gaps = 14/185 (7%)

Query: 813 LQPLPSPGVGGKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSD 871
           L P+P+       D+VFL+DGS S G   FQ V+  +  ++   ++G D  +V + Q+S 
Sbjct: 173 LPPVPA-------DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSG 225

Query: 872 DPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ 931
           D + E+ LN+ S+K++V  AV+RLR KGG     G AL +V     +   G R E    +
Sbjct: 226 DAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTF-TGLALTHVLGQNLQPAAGLRPE--AAK 282

Query: 932 FLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFR 988
            ++L++ GKS D+V   A  LK  GV  F +  +NAD+ EL  ++  P    V SV  F 
Sbjct: 283 VVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFL 342

Query: 989 ELPSL 993
           +L +L
Sbjct: 343 QLGAL 347



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 55/188 (29%), Positives = 85/188 (45%), Gaps = 9/188 (4%)

Query: 402 PQQLIQPLTTYVSGGVEEVPLAQ-----PESKRDILFLFDGSANLV-GQFPVVRDFLYKI 455
           P+Q  +P   +        P        P    D++FL DGS ++    F  V+DFL  +
Sbjct: 146 PEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASV 205

Query: 456 IDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDY 515
           I    + P+  ++ + QYS D + E   +   +K ++L  V+R++ K G     G AL +
Sbjct: 206 IAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTFT-GLALTH 264

Query: 516 AQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAE 575
                   +AG R E    + ++L+  G+S D V   A  LK  GV  F    KNAD AE
Sbjct: 265 VLGQNLQPAAGLRPE--AAKVVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAE 322

Query: 576 LEQIVLSP 583
           L  +   P
Sbjct: 323 LRLLASPP 330


>gi|38348304 von Willebrand factor A domain containing 2 [Homo
           sapiens]
          Length = 725

 Score =  110 bits (274), Expect = 9e-24
 Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D++FL+D S+   L  F   + F+ + ++ +       +V VA Y+  +        +  
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 156
             +++ ++  + P  G    TGSAL       F S+   R  +  P+ ++VL+T   S D
Sbjct: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 216
           E++ PA+  +   ++   +G++ A +AELEEI      V + ++     L   +P L   
Sbjct: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516

Query: 217 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 276
           L +    P   +   D++F+LD SA+VG  NF  ++ FV +     ++  D  +VGLV +
Sbjct: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575

Query: 277 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 336
                T F L+T  T++ +L  + Q    GG G + G+AL ++Y    T   G+  R  V
Sbjct: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632

Query: 337 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 383
           P+ +++LT G+  +     A  L   GI    VG        L ++A
Sbjct: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679



 Score =  100 bits (250), Expect = 5e-21
 Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)

Query: 426 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
           E + D+LFL D SA   +  F   + F+ + +  +  +    R+ VA YS ++ V     
Sbjct: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398

Query: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 544
           E+Q  P+++  +  +  + G  L  G AL  A    F  SA    +D   + +VLL    
Sbjct: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456

Query: 545 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 604
           S D V GPA + +   ++  +     A  AELE+I  SP  ++       + +  P++  
Sbjct: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515

Query: 605 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 663
            L S     P   +   D+VF+LD S  V    F  ++ FV+      +V  D  +V +V
Sbjct: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573

Query: 664 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 723
            Y  + +  F L++   +  ++ A+ Q   LGG   + G AL  +   ++    G+R   
Sbjct: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630

Query: 724 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 783
           GVP+ ++VLT  R  +D   P+  ++  G   + +G+G      ++ ++   D  + +  
Sbjct: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690

Query: 784 FRQLGTVQQVISE 796
           +  L   Q V+ E
Sbjct: 691 YADLRYHQDVLIE 703



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           DI+FLLDGS +VGK +F   + F + + + LDI  + +RVG  QFS TP  EF L+++ T
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 351
           + ++   ++++  +GG    T + L+  Y  H    GG      VPQ+L+++T G+S+  
Sbjct: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165

Query: 352 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 386
               +  L   G+  F VG       EL  +A  P
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++FLLD SA      F   + FV   V ++   +   RVG+  +S   +    +  YQ 
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 348
             D++  L  +  +GG  L TGSAL       F   T  G  R R    ++++LLT   S
Sbjct: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457

Query: 349 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 404
           ED     A       +L   VG S+A +AELE+I  +P  V +  D    F+ +P L  +
Sbjct: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516

Query: 405 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 463
           L             + P  + ++  D++F+ D SA++  + F  ++ F+     +  V P
Sbjct: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565

Query: 464 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 523
           + T++ +  Y   V+     D   ++  +L  + +     G   + G AL +    +   
Sbjct: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624

Query: 524 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 561
             G+R   GV + +V+L  GR ++    PA  L+ +G+
Sbjct: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)

Query: 622 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D++FLLD S G    GF   K FV+R V ++     R RV V  YS        +  Y +
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 737
             D+V ++  +   GGPT  TG+A    LR       GS    G     +++++LT   S
Sbjct: 403 VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457

Query: 738 GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 797
            D+V  P+   +    + +G+G   A   E++ I+               G+ + V+   
Sbjct: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501

Query: 798 VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 855
             Q    ++  LQ  L     PG   +  D+VF++D S S GPE F  +++ +       
Sbjct: 502 DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561

Query: 856 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 915
           +V  D T+V ++ +    +  F L+   ++  +  A+ +    GG   + G AL ++   
Sbjct: 562 EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620

Query: 916 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 962
           +     G+R   GVP+ +V+++ G+  ++   PA +L+  G++   +
Sbjct: 621 VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)

Query: 618 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
           S   D++FLLDGS  V  G F   K F   V + LD+  +RVRV   Q+S     EF L+
Sbjct: 47  SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106

Query: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 736
           S+  +Q+V   ++++   GG T  T  AL+++L   L    G R    VPQ+LI++T  +
Sbjct: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGI 760
           S  DV  PS  +K  G     +G+
Sbjct: 162 SQGDVALPSKQLKERGVTVFAVGV 185



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)

Query: 826 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D++FL+DGS S G   F+  +     + D LD+  +  RV   QFS  P +EF L++ S+
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 944
           + EV+  ++R+  KGGR        E   + +  R L       VPQ L++++ GKS  +
Sbjct: 111 QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165

Query: 945 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 978
           V  P+ +LK+ GV  F +  R    EEL  ++  P
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 45/152 (29%), Positives = 83/152 (54%), Gaps = 5/152 (3%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           DI+FL+DGS+++G  +F   + F   V   L+I  + ++V   Q++ T   EF  ++  T
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           ++EV   +++M    G    T  AL ++   L     G R A  +P++L+++T GKS  +
Sbjct: 111 QQEVKARIKRM-VFKGGRTETELALKYL---LHRGLPGGRNA-SVPQILIIVTDGKSQGD 165

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           ++ P+++LK   +  FA+G +     EL  +A
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALA 197



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)

Query: 430 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
           DI+FL DGS ++  G F   + F   + D L++ PE  R+   Q+S    +E   D   +
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 489 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 548
           + E+   +KRM  K G+        + A +Y+  +         V Q L+++  G+S   
Sbjct: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165

Query: 549 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 592
           V  P+  LK+ GV  F    +     EL  +   P    +L AE +
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 13/180 (7%)

Query: 826 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D++FL+D S     + F   +  ++R V  +       RV V  +S +  V   +  +  
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 941
             ++  ++  +  +GG  +  G+AL    R   +R  GS    G  +    +VL++   S
Sbjct: 403 VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457

Query: 942 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVS----TFRELPSLEQKL 997
           +DEV  PA   +   +    +   A + EL +I+ SP++V   S     F ++P L+ KL
Sbjct: 458 EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  107 bits (268), Expect = 4e-23
 Identities = 63/187 (33%), Positives = 111/187 (59%), Gaps = 5/187 (2%)

Query: 229 NKR-DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 287
           NKR D++F++D S +V   ++  V++F+++++  LDIG D  RVGL+Q+  T   EFSL 
Sbjct: 53  NKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLK 112

Query: 288 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAG 346
           T++ KS++   +++++    +G  TG A+ Y     F+EA G+R +RE+VP++++++T G
Sbjct: 113 TFKRKSEVERAVKRMR-HLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDG 171

Query: 347 QSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ 404
           + +DS  + A      GIL F +G  Q +   L+ I   P    V+L+ +FS +  L   
Sbjct: 172 RPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSV 231

Query: 405 LIQPLTT 411
             + L T
Sbjct: 232 FQKKLCT 238



 Score =  101 bits (252), Expect = 3e-21
 Identities = 57/180 (31%), Positives = 105/180 (58%), Gaps = 10/180 (5%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++F++DGS ++G+ NF  V+ FV  +++SL I     RVGL+Q+S    TEF+L  + +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 292 KSDI---LGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAGQ 347
             D+   + H++ +    G G  TG AL +++   FT+  G+R +   VP+  ++ T G+
Sbjct: 715 AKDMKKAVAHMKYM----GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 348 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM--DDFSSLPALPQQL 405
           ++D   + A+     GI  + VG  +A + EL++IA  P+  +L   +DFS++  + ++L
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 56/184 (30%), Positives = 102/184 (55%), Gaps = 6/184 (3%)

Query: 23  THAQQQ--QAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
           TH Q    ++  E  + D+VF++D S ++   ++  +++FI  ++Q L+IG D+ +V + 
Sbjct: 40  THPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLL 99

Query: 81  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AA 139
           QY  TV+ EF   T   K EV  AV++M+ L    + TG A+ +  N  F+ + G R   
Sbjct: 100 QYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNIAFSEAEGARPLR 158

Query: 140 EGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFI 197
           E +P++++++T G+  D +++ A + + + I+ FAIG    D   L+ I  +     VF+
Sbjct: 159 ENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFL 218

Query: 198 PAEF 201
            A F
Sbjct: 219 VANF 222



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 12/204 (5%)

Query: 599 HPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDR 657
           HPQ   L  S  N          D+VF++D S  V +  +  +KEF+  +++ LD+G D 
Sbjct: 41  HPQTALLESSCENK-------RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV 93

Query: 658 VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 717
            RV ++QY    + EF L ++  K +V  AV+++  L   T  TG A+++ L      + 
Sbjct: 94  TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGT-MTGLAIQYALNIAFSEAE 152

Query: 718 GSR-ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP- 775
           G+R + E VP++++++T  R  D V   +   +  G +   IG+G  D   +++I   P 
Sbjct: 153 GARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPH 212

Query: 776 -DFAVAIPTFRQLGTVQQVISERV 798
            D    +  F Q+ T+  V  +++
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKL 236



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 62/212 (29%), Positives = 106/212 (50%), Gaps = 10/212 (4%)

Query: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYL 855
           R   ++R   +R  P    L S     + D+VF+ID S+S    ++  V+  I  ++ +L
Sbjct: 28  RGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFL 87

Query: 856 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 915
           D+G D TRV ++Q+    K EF L     K EV+ AV+R+R      +  G A++Y    
Sbjct: 88  DIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNI 146

Query: 916 IFKRPLGSR-IEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVK 973
            F    G+R + E VP+ +++++ G+  D V + A + +  G+  F I     D   L  
Sbjct: 147 AFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKS 206

Query: 974 ISLSP--EYVFSVSTFRELPSL----EQKLLT 999
           I   P  ++VF V+ F ++ +L    ++KL T
Sbjct: 207 IGSEPHEDHVFLVANFSQIETLTSVFQKKLCT 238



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 49/153 (32%), Positives = 82/153 (53%), Gaps = 2/153 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++DGS +LG  NF  ++ F+  +I  L I     +V + QY+  V  EF      +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
            +++  AV  MK + G    TG AL  +    FT   G R  +  +P+  ++ T G++ D
Sbjct: 715 AKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           ++S+ A + K + I  +A+G   A + EL+EIA
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 49/159 (30%), Positives = 84/159 (52%), Gaps = 3/159 (1%)

Query: 619 GEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 677
           G  D+VF++DGS+ +    F ++K+FV  +++SL +     RV ++QYS +   EF L +
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 678 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTADR 736
           + + +D+  AV  +  +G  +  TG AL+ +         G+R ++  VP+  IV T  R
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGS-MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
           + DDV   +   K  G     +G+G A   E+Q I+  P
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 50/180 (27%), Positives = 96/180 (53%), Gaps = 6/180 (3%)

Query: 823 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+VF+IDGS+S G E F+ V+  +  ++D L +     RV ++Q+S     EF L  
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 940
            +S  +++ AV  ++  G   +  G AL+++    F +  G+R +   VP+  ++ + G+
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGSM-TGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 997
           + D+V + A + K  G+  + +    A +EEL +I+  P  +++F    F  +  + +KL
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 48/160 (30%), Positives = 74/160 (46%), Gaps = 3/160 (1%)

Query: 426 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
           E   D++F+ DGS +L  + F VV+ F+  IID L + P+  R+ + QYS  V  E    
Sbjct: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710

Query: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAG 543
              S  ++   V  MK   GK    G AL +     F +  G+R +   V +  ++   G
Sbjct: 711 NFNSAKDMKKAVAHMKY-MGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDG 769

Query: 544 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
           R+ D V   AS  K +G+  +      A   EL++I   P
Sbjct: 770 RAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 6/162 (3%)

Query: 426 ESKR-DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRF 483
           E+KR D++F+ D S ++    +  V++F+  I+  L++ P+ TR+ + QY   VK E   
Sbjct: 52  ENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSL 111

Query: 484 DEHQSKPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLV 541
              + K E+   VKRM+ + TG     G A+ YA    F ++ G+R + + V + ++++ 
Sbjct: 112 KTFKRKSEVERAVKRMRHLSTGTM--TGLAIQYALNIAFSEAEGARPLRENVPRVIMIVT 169

Query: 542 AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
            GR  D V   A+  + +G++ F       D   L+ I   P
Sbjct: 170 DGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEP 211


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  107 bits (268), Expect = 4e-23
 Identities = 63/187 (33%), Positives = 111/187 (59%), Gaps = 5/187 (2%)

Query: 229 NKR-DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 287
           NKR D++F++D S +V   ++  V++F+++++  LDIG D  RVGL+Q+  T   EFSL 
Sbjct: 53  NKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLK 112

Query: 288 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAG 346
           T++ KS++   +++++    +G  TG A+ Y     F+EA G+R +RE+VP++++++T G
Sbjct: 113 TFKRKSEVERAVKRMR-HLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDG 171

Query: 347 QSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ 404
           + +DS  + A      GIL F +G  Q +   L+ I   P    V+L+ +FS +  L   
Sbjct: 172 RPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSV 231

Query: 405 LIQPLTT 411
             + L T
Sbjct: 232 FQKKLCT 238



 Score =  101 bits (252), Expect = 3e-21
 Identities = 57/180 (31%), Positives = 105/180 (58%), Gaps = 10/180 (5%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++F++DGS ++G+ NF  V+ FV  +++SL I     RVGL+Q+S    TEF+L  + +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 292 KSDI---LGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAGQ 347
             D+   + H++ +    G G  TG AL +++   FT+  G+R +   VP+  ++ T G+
Sbjct: 715 AKDMKKAVAHMKYM----GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 348 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM--DDFSSLPALPQQL 405
           ++D   + A+     GI  + VG  +A + EL++IA  P+  +L   +DFS++  + ++L
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 56/184 (30%), Positives = 102/184 (55%), Gaps = 6/184 (3%)

Query: 23  THAQQQ--QAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVA 80
           TH Q    ++  E  + D+VF++D S ++   ++  +++FI  ++Q L+IG D+ +V + 
Sbjct: 40  THPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLL 99

Query: 81  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AA 139
           QY  TV+ EF   T   K EV  AV++M+ L    + TG A+ +  N  F+ + G R   
Sbjct: 100 QYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNIAFSEAEGARPLR 158

Query: 140 EGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFI 197
           E +P++++++T G+  D +++ A + + + I+ FAIG    D   L+ I  +     VF+
Sbjct: 159 ENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFL 218

Query: 198 PAEF 201
            A F
Sbjct: 219 VANF 222



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 12/204 (5%)

Query: 599 HPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDR 657
           HPQ   L  S  N          D+VF++D S  V +  +  +KEF+  +++ LD+G D 
Sbjct: 41  HPQTALLESSCENK-------RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV 93

Query: 658 VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 717
            RV ++QY    + EF L ++  K +V  AV+++  L   T  TG A+++ L      + 
Sbjct: 94  TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGT-MTGLAIQYALNIAFSEAE 152

Query: 718 GSR-ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP- 775
           G+R + E VP++++++T  R  D V   +   +  G +   IG+G  D   +++I   P 
Sbjct: 153 GARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPH 212

Query: 776 -DFAVAIPTFRQLGTVQQVISERV 798
            D    +  F Q+ T+  V  +++
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKL 236



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 62/212 (29%), Positives = 106/212 (50%), Gaps = 10/212 (4%)

Query: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYL 855
           R   ++R   +R  P    L S     + D+VF+ID S+S    ++  V+  I  ++ +L
Sbjct: 28  RGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFL 87

Query: 856 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 915
           D+G D TRV ++Q+    K EF L     K EV+ AV+R+R      +  G A++Y    
Sbjct: 88  DIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNI 146

Query: 916 IFKRPLGSR-IEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVK 973
            F    G+R + E VP+ +++++ G+  D V + A + +  G+  F I     D   L  
Sbjct: 147 AFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKS 206

Query: 974 ISLSP--EYVFSVSTFRELPSL----EQKLLT 999
           I   P  ++VF V+ F ++ +L    ++KL T
Sbjct: 207 IGSEPHEDHVFLVANFSQIETLTSVFQKKLCT 238



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 49/153 (32%), Positives = 82/153 (53%), Gaps = 2/153 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++DGS +LG  NF  ++ F+  +I  L I     +V + QY+  V  EF      +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
            +++  AV  MK + G    TG AL  +    FT   G R  +  +P+  ++ T G++ D
Sbjct: 715 AKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           ++S+ A + K + I  +A+G   A + EL+EIA
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 49/159 (30%), Positives = 84/159 (52%), Gaps = 3/159 (1%)

Query: 619 GEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 677
           G  D+VF++DGS+ +    F ++K+FV  +++SL +     RV ++QYS +   EF L +
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 678 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTADR 736
           + + +D+  AV  +  +G  +  TG AL+ +         G+R ++  VP+  IV T  R
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGS-MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
           + DDV   +   K  G     +G+G A   E+Q I+  P
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 50/180 (27%), Positives = 96/180 (53%), Gaps = 6/180 (3%)

Query: 823 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+VF+IDGS+S G E F+ V+  +  ++D L +     RV ++Q+S     EF L  
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 940
            +S  +++ AV  ++  G   +  G AL+++    F +  G+R +   VP+  ++ + G+
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGSM-TGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 997
           + D+V + A + K  G+  + +    A +EEL +I+  P  +++F    F  +  + +KL
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 48/160 (30%), Positives = 74/160 (46%), Gaps = 3/160 (1%)

Query: 426 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
           E   D++F+ DGS +L  + F VV+ F+  IID L + P+  R+ + QYS  V  E    
Sbjct: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710

Query: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAG 543
              S  ++   V  MK   GK    G AL +     F +  G+R +   V +  ++   G
Sbjct: 711 NFNSAKDMKKAVAHMKY-MGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDG 769

Query: 544 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
           R+ D V   AS  K +G+  +      A   EL++I   P
Sbjct: 770 RAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 6/162 (3%)

Query: 426 ESKR-DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRF 483
           E+KR D++F+ D S ++    +  V++F+  I+  L++ P+ TR+ + QY   VK E   
Sbjct: 52  ENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSL 111

Query: 484 DEHQSKPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLV 541
              + K E+   VKRM+ + TG     G A+ YA    F ++ G+R + + V + ++++ 
Sbjct: 112 KTFKRKSEVERAVKRMRHLSTGTM--TGLAIQYALNIAFSEAEGARPLRENVPRVIMIVT 169

Query: 542 AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
            GR  D V   A+  + +G++ F       D   L+ I   P
Sbjct: 170 DGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEP 211


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 66/198 (33%), Positives = 107/198 (54%), Gaps = 12/198 (6%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD--IGNDNIRVGLVQFSDTPVTEFSLNTY 289
           DI+FLLDGS+++G++NF  VR F+  LV           +R   VQ+SD P TEF L+  
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 290 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349
            +  D++  +R+L  +GG+   TG+A+ +V  + F        R  VP++ +L+T G+S+
Sbjct: 98  GSGGDVIRAIRELSYKGGN-TRTGAAILHVADHVFLP---QLARPGVPKVCILITDGKSQ 153

Query: 350 DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLIQ 407
           D    AA  L   G+  F VG   A+  EL+++A  P+    + ++DFS L  L   + +
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 408 PLTTYVSGGVEEVPLAQP 425
            + T   G    VP+ +P
Sbjct: 214 RVCTTAGG----VPVTRP 227



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 64/186 (34%), Positives = 99/186 (53%), Gaps = 9/186 (4%)

Query: 9   LVAVFCL-FLSGFPTTHAQQQQAVI--EVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 65
           LVA  C   L+  P   AQ ++ V    +   DIVFL+DGSS++G +NF  +R F+  ++
Sbjct: 6   LVAALCAGILAEAPRVRAQHRERVTCTRLYAADIVFLLDGSSSIGRSNFREVRSFLEGLV 65

Query: 66  QRLEIGQDL--IQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALD 123
                      ++ A  QY+D  R EF  +   +  +VI A+R++    G+   TG+A+ 
Sbjct: 66  LPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGDVIRAIRELSYKGGNTR-TGAAIL 124

Query: 124 FVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA 183
            V +++F       A  G+PK+ +LIT GKS D +   AQ LK   +  FA+G K AD  
Sbjct: 125 HVADHVFLPQL---ARPGVPKVCILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNADPE 181

Query: 184 ELEEIA 189
           EL+ +A
Sbjct: 182 ELKRVA 187



 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 67/174 (38%), Positives = 96/174 (55%), Gaps = 10/174 (5%)

Query: 826 DVVFLIDGSQSAG-PEFQYVRTLIERLVDYLD--VGFDTTRVAVIQFSDDPKVEFLLNAH 882
           D+VFL+DGS S G   F+ VR+ +E LV            R A +Q+SDDP+ EF L+A 
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 883 SSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSD 942
            S  +V  A++ L  KGG     G A+ +V+ ++F   L      GVP+  +LI+ GKS 
Sbjct: 98  GSGGDVIRAIRELSYKGG-NTRTGAAILHVADHVF---LPQLARPGVPKVCILITDGKSQ 153

Query: 943 DEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSP--EYVFSVSTFRELPSL 993
           D VD  A  LK  GV  F +  +NAD EEL +++  P  ++ F V+ F  L +L
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTL 207



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 109/220 (49%), Gaps = 15/220 (6%)

Query: 622 DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLD--VGQDRVRVAVVQYSDRTRPEFYLNSY 678
           D+VFLLDGS  + RS F  ++ F++ +V           VR A VQYSD  R EF L++ 
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 679 MNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSG 738
            +  DV+ A+R+L+  GG T  TGAA+  V  ++ +         GVP++ I++T  +S 
Sbjct: 98  GSGGDVIRAIRELSYKGGNT-RTGAAILHVADHVFLPQLA---RPGVPKVCILITDGKSQ 153

Query: 739 DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQVISE 796
           D V   +  +K  G     +GI NAD  E++ ++  P  DF   +  F  L T+  ++S 
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 797 RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQS 836
           RV            PV +P P       RD+V     SQS
Sbjct: 214 RVCTTAGG-----VPVTRP-PDDSTSAPRDLVLSEPSSQS 247



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 60/216 (27%), Positives = 95/216 (43%), Gaps = 15/216 (6%)

Query: 430 DILFLFDGSANLV-GQFPVVRDFLYKIIDELN--VKPEGTRIAVAQYSDDVKVESRFDEH 486
           DI+FL DGS+++    F  VR FL  ++   +     +G R A  QYSDD + E   D  
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 487 QSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSS 546
            S  +++  ++ +  K G     G A+ +   ++F+         GV +  +L+  G+S 
Sbjct: 98  GSGGDVIRAIRELSYKGGNT-RTGAAILHVADHVFLPQLA---RPGVPKVCILITDGKSQ 153

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA--FILAAESLPKIGDLHPQIVN 604
           D VD  A  LK  GV  F    KNADP EL+++   P   F         +  L P +  
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 605 LLKSVHNGAPA------PVSGEKDVVFLLDGSEGVR 634
            + +   G P         S  +D+V     S+ +R
Sbjct: 214 RVCTTAGGVPVTRPPDDSTSAPRDLVLSEPSSQSLR 249



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 3/205 (1%)

Query: 614  PAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLD-VGQDRVRVAVVQYSDRTRPE 672
            P    G  DVVFL   ++         +  ++R+V +L  +G   V+V ++ YS R  P 
Sbjct: 1046 PVCPRGLADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPL 1105

Query: 673  FYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVL 732
            F LN   +   ++  +R +  +     N G A+    R +L   A  R  + VP ++++L
Sbjct: 1106 FPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGR-RQHVPGVMVLL 1164

Query: 733  TADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQ 792
              +    D+ +P    +  G   + +G+  AD  +++ ++   D            ++ Q
Sbjct: 1165 VDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQ 1224

Query: 793  VISERVTQLTREELSRLQPVLQPLP 817
             +S   T L +   +  QP  +P P
Sbjct: 1225 AVSGLATALCQASFT-TQPRPEPCP 1248



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 58/229 (25%), Positives = 94/229 (41%), Gaps = 26/229 (11%)

Query: 795  SERVTQLTR--EELSRLQPVLQPLPSPGVG---------GKRDVVFLIDGSQSAGPEFQY 843
            S+RVT L      +  L PVL  +  P            G  DVVFL   +Q      + 
Sbjct: 1012 SQRVTGLEPGVSYIFSLTPVLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEA 1071

Query: 844  VRTLIERLVDYL-DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLR------ 896
             R ++ERLV  L  +G    +V ++ +S  P   F LN      ++   +QR+R      
Sbjct: 1072 TRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPLFPLN---GSHDLGIILQRIRDMPYMD 1128

Query: 897  PKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFG 956
            P G    N+G A+    R +       R  + VP  +VL+       ++  P  E +  G
Sbjct: 1129 PSGN---NLGTAVVTAHRYMLAPDAPGR-RQHVPGVMVLLVDEPLRGDIFSPIREAQASG 1184

Query: 957  VAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTL 1004
            +    +    AD E+L +++   + V +     + PSL+Q +    T L
Sbjct: 1185 LNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQAVSGLATAL 1233



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 36/164 (21%), Positives = 64/164 (39%), Gaps = 3/164 (1%)

Query: 417  VEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELN-VKPEGTRIAVAQYSD 475
            V + P+  P    D++FL   + +   +    R  L +++  L  + P+  ++ +  YS 
Sbjct: 1042 VTQTPVC-PRGLADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSH 1100

Query: 476  DVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQ 535
                    +       IL  ++ M        NLG A+  A RY+    A  R    V  
Sbjct: 1101 RPSPLFPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGR-RQHVPG 1159

Query: 536  FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 579
             +VLLV       +  P    + SG+   +     ADP +L ++
Sbjct: 1160 VMVLLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRL 1203


>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
          Length = 540

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 62/177 (35%), Positives = 100/177 (56%), Gaps = 4/177 (2%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++ L+DGS +V   NF  V+ FV  +V+ LD+  +  RVGLVQFS    TEF L  Y T
Sbjct: 304 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 363

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 350
            +++   +  ++     G  TG AL ++  + F+EA G+R R  +VP++ L+ T G+S+D
Sbjct: 364 AAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 422

Query: 351 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQL 405
                A      GI+ + VG  +A +AEL +IA  P+ +++    DF ++  L + L
Sbjct: 423 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 479



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 8/189 (4%)

Query: 213 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 269
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 270 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 329
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 330 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 386
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 387 SLVYLMDDF 395
             V+L++ F
Sbjct: 191 EHVFLVESF 199



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 59/170 (34%), Positives = 87/170 (51%), Gaps = 12/170 (7%)

Query: 619 GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 677
           G  D+V L+DGS+ VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  
Sbjct: 301 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 360

Query: 678 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADR 736
           Y    +V  AV  +  +   T  TG AL  ++ +    + G+R     VP++ +V T  R
Sbjct: 361 YGTAAEVKQAVLAVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 419

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTI---------SFIPDF 777
           S DD+   +   K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 420 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 469



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 59/184 (32%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+V LVDGS ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T
Sbjct: 304 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 363

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
             EV  AV  ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D
Sbjct: 364 AAEVKQAVLAVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 422

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLL 214
           +IS  A   K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL
Sbjct: 423 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLL 476

Query: 215 APLR 218
             LR
Sbjct: 477 ENLR 480



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 823 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31  GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 940
            S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91  FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 987
             D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150 PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 2/153 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++D S ++    F  +R F+  +++ L +G +  +V V QY+  V+  F       
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
           + ++  A+R + PL      TG A+ +  N  F+ + G R   E +P++ V++T G+  D
Sbjct: 94  REDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
            +++ A + +   I  +A+G + AD   L  +A
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMA 185



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 44/160 (27%), Positives = 85/160 (53%), Gaps = 3/160 (1%)

Query: 618 SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
           +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30  TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 735
           ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90  AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 736 RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
           R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 149 RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 4/159 (2%)

Query: 823 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+V L+DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  
Sbjct: 301 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 360

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGK 940
           + +  EV+ AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+
Sbjct: 361 YGTAAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 419

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 978
           S D++   A   K+ G+  + +    A + EL +I+  P
Sbjct: 420 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEP 458



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 4/186 (2%)

Query: 426 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
           E   D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  V+ E    
Sbjct: 300 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 359

Query: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAG 543
            + +  E+   V  ++    +    G AL +   + F ++ G+R     V +  ++   G
Sbjct: 360 RYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDG 418

Query: 544 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIV 603
           RS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  G +   + 
Sbjct: 419 RSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDFGTMTHLLE 477

Query: 604 NLLKSV 609
           NL  S+
Sbjct: 478 NLRGSI 483



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 45/157 (28%), Positives = 74/157 (47%), Gaps = 5/157 (3%)

Query: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 487
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 488 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 546
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
           DRV   A+  +  G+  +    + AD   L  +   P
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188


>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
          Length = 581

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 62/177 (35%), Positives = 100/177 (56%), Gaps = 4/177 (2%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 291
           D++ L+DGS +V   NF  V+ FV  +V+ LD+  +  RVGLVQFS    TEF L  Y T
Sbjct: 345 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 404

Query: 292 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 350
            +++   +  ++     G  TG AL ++  + F+EA G+R R  +VP++ L+ T G+S+D
Sbjct: 405 AAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 463

Query: 351 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQL 405
                A      GI+ + VG  +A +AEL +IA  P+ +++    DF ++  L + L
Sbjct: 464 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 520



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 8/189 (4%)

Query: 213 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 269
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 270 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 329
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 330 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 386
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 387 SLVYLMDDF 395
             V+L++ F
Sbjct: 191 EHVFLVESF 199



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 59/170 (34%), Positives = 87/170 (51%), Gaps = 12/170 (7%)

Query: 619 GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 677
           G  D+V L+DGS+ VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  
Sbjct: 342 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 401

Query: 678 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADR 736
           Y    +V  AV  +  +   T  TG AL  ++ +    + G+R     VP++ +V T  R
Sbjct: 402 YGTAAEVKQAVLAVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 460

Query: 737 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTI---------SFIPDF 777
           S DD+   +   K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 461 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 510



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 59/184 (32%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+V LVDGS ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T
Sbjct: 345 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 404

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
             EV  AV  ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D
Sbjct: 405 AAEVKQAVLAVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 463

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLL 214
           +IS  A   K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL
Sbjct: 464 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLL 517

Query: 215 APLR 218
             LR
Sbjct: 518 ENLR 521



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 823 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31  GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 940
            S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91  FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 987
             D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150 PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 2/153 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++D S ++    F  +R F+  +++ L +G +  +V V QY+  V+  F       
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
           + ++  A+R + PL      TG A+ +  N  F+ + G R   E +P++ V++T G+  D
Sbjct: 94  REDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
            +++ A + +   I  +A+G + AD   L  +A
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMA 185



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 44/160 (27%), Positives = 85/160 (53%), Gaps = 3/160 (1%)

Query: 618 SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 676
           +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30  TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 677 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 735
           ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90  AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 736 RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
           R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 149 RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 4/159 (2%)

Query: 823 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881
           G  D+V L+DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  
Sbjct: 342 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 401

Query: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGK 940
           + +  EV+ AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+
Sbjct: 402 YGTAAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 460

Query: 941 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 978
           S D++   A   K+ G+  + +    A + EL +I+  P
Sbjct: 461 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEP 499



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 4/186 (2%)

Query: 426 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 484
           E   D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  V+ E    
Sbjct: 341 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 400

Query: 485 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAG 543
            + +  E+   V  ++    +    G AL +   + F ++ G+R     V +  ++   G
Sbjct: 401 RYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDG 459

Query: 544 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIV 603
           RS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  G +   + 
Sbjct: 460 RSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDFGTMTHLLE 518

Query: 604 NLLKSV 609
           NL  S+
Sbjct: 519 NLRGSI 524



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 45/157 (28%), Positives = 74/157 (47%), Gaps = 5/157 (3%)

Query: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 487
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 488 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 546
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
           DRV   A+  +  G+  +    + AD   L  +   P
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188


>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
          Length = 957

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 63/204 (30%), Positives = 107/204 (52%), Gaps = 13/204 (6%)

Query: 213 LLAPLRTLSGTPEVHSNKR----DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN 268
           LL     L+   EV S+ R    D++F+LDGS +VG  NF  V+ +++N+  + DIG   
Sbjct: 14  LLLQNSVLAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKF 73

Query: 269 IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 328
           I+VG+VQ+SD PV E  L +Y +   +   +  +   GG+   TG A+ +     F ++ 
Sbjct: 74  IQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGN-TKTGKAIQFALDYLFAKSS 132

Query: 329 GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVG-ASQANKAELEQIAFNPS 387
                  + ++ ++LT G+S+D    AA A   + I  F +G  S+   AEL  IA  PS
Sbjct: 133 -----RFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPS 187

Query: 388 LVYL--MDDFSSLPALPQQLIQPL 409
             Y+  ++D+ ++  + + + Q L
Sbjct: 188 STYVFYVEDYIAISKIREVMKQKL 211



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 51/161 (31%), Positives = 84/161 (52%), Gaps = 7/161 (4%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++DGS ++G  NF  ++ ++  + +  +IG   IQV V QY+D    E    ++ +
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
              +  AV  +  L G+   TG A+ F  + LF  S+ +     + K+ V++T GKS D+
Sbjct: 97  GEHLTAAVESILYLGGNT-KTGKAIQFALDYLFAKSSRF-----LTKIAVVLTDGKSQDD 150

Query: 158 ISQPAQELKRSSIMAFAIG-NKGADQAELEEIAFDSSLVFI 197
           +   AQ  + S I  FAIG     + AEL  IA   S  ++
Sbjct: 151 VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYV 191



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 49/183 (26%), Positives = 97/183 (53%), Gaps = 10/183 (5%)

Query: 622 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 680
           D+VF+LDGS  V    F ++K+++  + ++ D+G   ++V VVQYSD    E  L SY +
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 681 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 740
            + +  AV  +  LGG T  TG A++F L  +   S     +  + ++ +VLT  +S DD
Sbjct: 97  GEHLTAAVESILYLGGNT-KTGKAIQFALDYLFAKS-----SRFLTKIAVVLTDGKSQDD 150

Query: 741 VRNPSVVVKRGGAVPIGIGIGN-ADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISER 797
           V++ +   +        IG+G+  +  E++ I+  P   +   +  +  +  +++V+ ++
Sbjct: 151 VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQK 210

Query: 798 VTQ 800
           + +
Sbjct: 211 LCE 213



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 51/175 (29%), Positives = 89/175 (50%), Gaps = 11/175 (6%)

Query: 826 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D+VF++DGS S GPE F+ V+  +  +    D+G    +V V+Q+SD P +E  L ++ S
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 944
            + +  AV+ +   GG     G A+++    +F +   SR    + +  V+++ GKS D+
Sbjct: 97  GEHLTAAVESILYLGG-NTKTGKAIQFALDYLFAK--SSRF---LTKIAVVLTDGKSQDD 150

Query: 945 VDDPAVELKQFGVAPFTIARNADQE--ELVKISLSPE--YVFSVSTFRELPSLEQ 995
           V D A   +   +  F I   ++ E  EL  I+  P   YVF V  +  +  + +
Sbjct: 151 VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIRE 205


>gi|11321565 matrilin 3 precursor [Homo sapiens]
          Length = 486

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 48/153 (31%), Positives = 86/153 (56%), Gaps = 2/153 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+VF++D S ++    F  ++ F++++I  L+IG    +VAV  YA TV+ EF    +  
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 156
           K+ +  AV ++ PL    + +G A+    +  FT  AG R  +  IPK+ +++T G+  D
Sbjct: 143 KQSLKQAVGRITPLSTGTM-SGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201

Query: 157 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           ++++ A   + S I  +A+G   AD A L+ +A
Sbjct: 202 QVNEVAARAQASGIELYAVGVDRADMASLKMMA 234



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 53/176 (30%), Positives = 95/176 (53%), Gaps = 6/176 (3%)

Query: 826 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 884
           D+VF+ID S+S  P EF  V+T + R++D LD+G   TRVAV+ ++   K+EF L A++ 
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 885 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGKSDD 943
           K  ++ AV R+ P     ++ G A++      F    G+R     +P+  ++++ G+  D
Sbjct: 143 KQSLKQAVGRITPLSTGTMS-GLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201

Query: 944 EVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 996
           +V++ A   +  G+  + +    AD   L  ++  P  E+VF V T+  +  L  +
Sbjct: 202 QVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSR 257



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 3/166 (1%)

Query: 612 GAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTR 670
           GA    S   D+VF++D S  VR   F  +K FV R++++LD+G    RVAVV Y+   +
Sbjct: 73  GAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVK 132

Query: 671 PEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLL 729
            EF L +Y +KQ +  AV ++T L   T  +G A++  +       AG+R  +  +P++ 
Sbjct: 133 IEFQLQAYTDKQSLKQAVGRITPLSTGT-MSGLAIQTAMDEAFTVEAGAREPSSNIPKVA 191

Query: 730 IVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 775
           I++T  R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 192 IIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEP 237



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 53/187 (28%), Positives = 89/187 (47%), Gaps = 7/187 (3%)

Query: 203 AAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSL 262
           AAP      G   P R   G     S   D++F++D S +V    F  V+ FV  ++++L
Sbjct: 55  AAPDGAPASGTSEPGRA-RGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTL 113

Query: 263 DIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDI---LGHLRQLQLQGGSGLNTGSALSYV 319
           DIG  + RV +V ++ T   EF L  Y  K  +   +G +  L     SGL   +A+   
Sbjct: 114 DIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEA 173

Query: 320 YANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL 379
           +     EAG      ++P++ +++T G+ +D   + A     +GI  + VG  +A+ A L
Sbjct: 174 FT---VEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASL 230

Query: 380 EQIAFNP 386
           + +A  P
Sbjct: 231 KMMASEP 237



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 44/157 (28%), Positives = 78/157 (49%), Gaps = 5/157 (3%)

Query: 430 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 488
           D++F+ D S ++   +F  V+ F+ +IID L++ P  TR+AV  Y+  VK+E +   +  
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 489 KPEILNLVKRM-KIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 546
           K  +   V R+  + TG     G A+  A    F   AG+R     + +  +++  GR  
Sbjct: 143 KQSLKQAVGRITPLSTGTM--SGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQ 200

Query: 547 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 583
           D+V+  A+  + SG+  +      AD A L+ +   P
Sbjct: 201 DQVNEVAARAQASGIELYAVGVDRADMASLKMMASEP 237


>gi|40068485 von Willebrand factor A domain containing 1 isoform 1
           [Homo sapiens]
          Length = 445

 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 75/235 (31%), Positives = 101/235 (42%), Gaps = 32/235 (13%)

Query: 224 PEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTE 283
           P   + + D++FLLD SA+V    F  VR+FV  LV  L +G   +R  LV     P TE
Sbjct: 26  PPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTE 85

Query: 284 FSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLL 343
           F    + +       +R    + G   +TG AL Y     F EA G+  R  VP++L+ +
Sbjct: 86  FPFGQHSSGEAAQDAVRASAQRMGD-THTGLALVYAKEQLFAEASGA--RPGVPKVLVWV 142

Query: 344 TAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL----MDDF---- 395
           T G S D        L   G+  F V   + N  EL   A  P+  +L    +DD     
Sbjct: 143 TDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIV 202

Query: 396 -----SSLPAL-PQQL-------------IQPLTTYVSG--GVEEVPLAQPESKR 429
                S L A+ PQQL               PL T  SG   +E VP AQP + R
Sbjct: 203 QELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAAR 257



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 3/152 (1%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D++FL+D S+++    F+ +R+F+ +++  L +G   ++ ++         EF F  H +
Sbjct: 34  DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
                 AVR      G   +TG AL + +  LF  ++G  A  G+PK+LV +T G S D 
Sbjct: 94  GEAAQDAVRASAQRMGDT-HTGLALVYAKEQLFAEASG--ARPGVPKVLVWVTDGGSSDP 150

Query: 158 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA 189
           +  P QELK   +  F +     +  EL   A
Sbjct: 151 VGPPMQELKDLGVTVFIVSTGRGNFLELSAAA 182



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 819 PGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEF 877
           P    + D++FL+D S S    EF  VR  + +LV  L +G    R +++     P  EF
Sbjct: 27  PASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEF 86

Query: 878 LLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLIS 937
               HSS +  Q+AV+    + G   + G AL Y    +F    G+R   GVP+ LV ++
Sbjct: 87  PFGQHSSGEAAQDAVRASAQRMG-DTHTGLALVYAKEQLFAEASGAR--PGVPKVLVWVT 143

Query: 938 SGKSDDEVDDPAVELKQFGVAPFTIA 963
            G S D V  P  ELK  GV  F ++
Sbjct: 144 DGGSSDPVGPPMQELKDLGVTVFIVS 169



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 50/172 (29%), Positives = 79/172 (45%), Gaps = 6/172 (3%)

Query: 414 SGGVEEVPLAQPESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQ 472
           SG     P + P    D++FL D SA++   +F  VR+F+ +++  L +     R ++  
Sbjct: 20  SGAERGPPASAPRG--DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVH 77

Query: 473 YSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDG 532
                  E  F +H S     + V+    + G   + G AL YA+  +F +++G+R   G
Sbjct: 78  VGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDT-HTGLALVYAKEQLFAEASGAR--PG 134

Query: 533 VLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA 584
           V + LV +  G SSD V  P   LK  GV  FI      +  EL     +PA
Sbjct: 135 VPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPA 186


>gi|31657142 integrin, alpha 1 precursor [Homo sapiens]
          Length = 1179

 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 42/145 (28%), Positives = 79/145 (54%), Gaps = 6/145 (4%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           DIV ++DGS+++    ++++  F+  +++R++IG    QV + QY + V  EF  N + +
Sbjct: 172 DIVIVLDGSNSI--YPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSS 229

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLD- 156
             EV+ A +K+    G    T   +D  R   FT + G  A  G+ K++V++T G+S D 
Sbjct: 230 TEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARG--ARRGVKKVMVIVTDGESHDN 287

Query: 157 -EISQPAQELKRSSIMAFAIGNKGA 180
             + +  Q+ +  +I  F+I   G+
Sbjct: 288 HRLKKVIQDCEDENIQRFSIAILGS 312



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 36/118 (30%), Positives = 67/118 (56%), Gaps = 3/118 (2%)

Query: 826 DVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSK 885
           D+V ++DGS S  P +  V   +  L++ +D+G   T+V ++Q+ ++   EF LN +SS 
Sbjct: 172 DIVIVLDGSNSIYP-WDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSST 230

Query: 886 DEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDD 943
           +EV  A +++  +GGRQ      ++   +  F    G+R   GV + +V+++ G+S D
Sbjct: 231 EEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR--RGVKKVMVIVTDGESHD 286



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 38/127 (29%), Positives = 72/127 (56%), Gaps = 8/127 (6%)

Query: 228 SNKRDIIFLLDGSANVGKTNFPY--VRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFS 285
           S + DI+ +LDGS ++    +P+  V  F+ +L+  +DIG    +VG+VQ+ +    EF+
Sbjct: 168 STQLDIVIVLDGSNSI----YPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFN 223

Query: 286 LNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTA 345
           LN Y +  ++L   +++  +GG    T   +       FTEA G+  R  V ++++++T 
Sbjct: 224 LNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGA--RRGVKKVMVIVTD 281

Query: 346 GQSEDSY 352
           G+S D++
Sbjct: 282 GESHDNH 288



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 8/147 (5%)

Query: 601 QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 660
           Q+VN +  V        S + D+V +LDGS  +   +  +  F+  ++E +D+G  + +V
Sbjct: 156 QVVNSIAPVQE-----CSTQLDIVIVLDGSNSIYP-WDSVTAFLNDLLERMDIGPKQTQV 209

Query: 661 AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR 720
            +VQY +    EF LN Y + ++V+ A +++   GG    T   ++   +     + G+R
Sbjct: 210 GIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR 269

Query: 721 ITEGVPQLLIVLTADRSGDDVRNPSVV 747
              GV ++++++T   S D+ R   V+
Sbjct: 270 --RGVKKVMVIVTDGESHDNHRLKKVI 294



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 32/127 (25%), Positives = 70/127 (55%), Gaps = 3/127 (2%)

Query: 421 PLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVE 480
           P+ +  ++ DI+ + DGS N +  +  V  FL  +++ +++ P+ T++ + QY ++V  E
Sbjct: 163 PVQECSTQLDIVIVLDGS-NSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHE 221

Query: 481 SRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLL 540
              +++ S  E+L   K++  + G+       +D A++  F ++ G+R   GV + +V++
Sbjct: 222 FNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR--RGVKKVMVIV 279

Query: 541 VAGRSSD 547
             G S D
Sbjct: 280 TDGESHD 286


>gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens]
          Length = 1028

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 97/372 (26%), Positives = 141/372 (37%), Gaps = 54/372 (14%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRL--------EIGQDLIQVAVAQYADTVRPE 89
           D++F++D S ++GL NF   +DF+ KVI RL        E GQ      V QY+ +   E
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQS--YAGVVQYSHSQMQE 672

Query: 90  FYFNTHPTKREVITAVRKMKPLDGSA--LYTGSALDFVRNNLFTSSAGYRAAEGIPKLLV 147
                 P+ R V      +K L   A   +TG AL + R+ L   S   R A      LV
Sbjct: 673 HVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIA------LV 726

Query: 148 LITGGKSLDEISQPAQELKRSSIMAFAIGNK-------GADQAE------LEEIAFDSSL 194
           +  G       + P   L    I   ++G K       G+DQ        L        L
Sbjct: 727 ITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGL 786

Query: 195 VFIPAEFRAAPLQGMLPGLLAPLRTLSGTPE-----VHSNKRDIIFLLDGSANVGKTNFP 249
             +   +        L  + A +      P+       S+  DI  LLDGSA+VG  NF 
Sbjct: 787 SLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFD 846

Query: 250 YVRDFVMNLVNS-LDIGN----DNIRVGLVQFSDT---PVTEFSLNTYQTKSDILGHLRQ 301
             + F   L    L  G      ++RV +VQ+S T        SL   Q  + +   +  
Sbjct: 847 TTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDA 906

Query: 302 LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED----SYLQAAN 357
           +        +   AL YV    + EA     ++     LLL + G S+     +  +A  
Sbjct: 907 MDFI-NDATDVNDALGYV-TRFYREASSGAAKKR----LLLFSDGNSQGATPAAIEKAVQ 960

Query: 358 ALTRAGILTFCV 369
              RAGI  F V
Sbjct: 961 EAQRAGIEIFVV 972



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 88/335 (26%), Positives = 135/335 (40%), Gaps = 60/335 (17%)

Query: 430 DILFLFDGSANL-VGQFPVVRDFLYKIIDELN------VKPEGTRIAVAQYSDDVKVESR 482
           D+LF+ D S ++ +  F + +DF+ K+ID L+       +P  +   V QYS      S+
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYS-----HSQ 669

Query: 483 FDEHQS--KPEILNL------VKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 534
             EH S   P I N+      +K ++   G     G AL Y +  +   S  +RI     
Sbjct: 670 MQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFT-GEALQYTRDQLLPPSPNNRIA---- 724

Query: 535 QFLVLLVAGRSSDRVDG-PASNLKQSGVVPFIFQAKNAD---PAELEQIVLSPAFILAAE 590
              +++  GRS  + D  P + L   G+       K+     P   +  V+S   +  ++
Sbjct: 725 ---LVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQ 781

Query: 591 SLPKIGDLHPQIVNLL----------------KSVHNGAPAPVSGEKDVVFLLDGSEGVR 634
             P +  +      LL                K      P   S   D+  LLDGS  V 
Sbjct: 782 GRPGLSLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVG 841

Query: 635 S-GFPLLKEFVQRVVESL------DVGQDRVRVAVVQYS--DRTRPE-FYLNSYMNKQDV 684
           S  F   K F +R+ E        D   D VRVAVVQYS   + RPE   L    N   +
Sbjct: 842 SHNFDTTKRFAKRLAERFLTAGRTDPAHD-VRVAVVQYSGTGQQRPERASLQFLQNYTAL 900

Query: 685 VNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGS 719
            +AV  +  +   T +   AL +V R    +S+G+
Sbjct: 901 ASAVDAMDFINDAT-DVNDALGYVTRFYREASSGA 934



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 65/275 (23%), Positives = 112/275 (40%), Gaps = 42/275 (15%)

Query: 232 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD------IGNDNIRVGLVQFSDTPVTE-F 284
           D++F+LD S ++G  NF   +DFV+ +++ L               G+VQ+S + + E  
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHV 674

Query: 285 SLNTYQTKS--DILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLL 342
           SL +   ++  ++   ++ LQ   G G  TG AL Y        +  +RI        L+
Sbjct: 675 SLRSPSIRNVQELKEAIKSLQWMAG-GTFTGEALQYTRDQLLPPSPNNRI-------ALV 726

Query: 343 LTAGQSEDSY-LQAANALTRAGI----------LTFCVGASQANKAELEQIA---FNPSL 388
           +T G+S+        N L   GI            F  G+ Q N    + +A     P L
Sbjct: 727 ITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGL 786

Query: 389 VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP---ESKRDILFLFDGSANLVG-Q 444
             + ++++ L  L    ++ +T  +    +      P    S  DI  L DGSA++    
Sbjct: 787 SLVKENYAEL--LEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHN 844

Query: 445 FPVVRDFLYKIIDEL-----NVKPEGTRIAVAQYS 474
           F   + F  ++ +              R+AV QYS
Sbjct: 845 FDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYS 879


>gi|38569398 integrin, alpha 10 precursor [Homo sapiens]
          Length = 1167

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 9/154 (5%)

Query: 216 PLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPY--VRDFVMNLVNSLDIGNDNIRVGL 273
           P  +L+ T +      D++ +LDGS ++    +P+  V+ F+  LV  L I  + I+VGL
Sbjct: 151 PQGSLAPTAQRCPTYMDVVIVLDGSNSI----YPWSEVQTFLRRLVGKLFIDPEQIQVGL 206

Query: 274 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333
           VQ+ ++PV E+SL  ++TK +++   + L  + G    T  A+       F+++ G   R
Sbjct: 207 VQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGG--R 264

Query: 334 EHVPQLLLLLTAGQSED-SYLQAANALTRAGILT 366
               +LL+++T G+S D   L AA     AG +T
Sbjct: 265 PEAARLLVVVTDGESHDGEELPAALKACEAGRVT 298



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 3/124 (2%)

Query: 826 DVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSK 885
           DVV ++DGS S  P +  V+T + RLV  L +  +  +V ++Q+ + P  E+ L    +K
Sbjct: 167 DVVIVLDGSNSIYP-WSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTK 225

Query: 886 DEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEV 945
           +EV  A + L  + GR+     A+       F +  G R E    + LV+++ G+S D  
Sbjct: 226 EEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPE--AARLLVVVTDGESHDGE 283

Query: 946 DDPA 949
           + PA
Sbjct: 284 ELPA 287



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 35/125 (28%), Positives = 65/125 (52%), Gaps = 4/125 (3%)

Query: 38  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 97
           D+V ++DGS+++    ++ ++ F+ +++ +L I  + IQV + QY ++   E+      T
Sbjct: 167 DVVIVLDGSNSI--YPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRT 224

Query: 98  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 157
           K EV+ A + +   +G    T  A+       F+ S G R      +LLV++T G+S D 
Sbjct: 225 KEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAA--RLLVVVTDGESHDG 282

Query: 158 ISQPA 162
              PA
Sbjct: 283 EELPA 287



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 32/125 (25%), Positives = 62/125 (49%), Gaps = 3/125 (2%)

Query: 430 DILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSK 489
           D++ + DGS N +  +  V+ FL +++ +L + PE  ++ + QY +    E    + ++K
Sbjct: 167 DVVIVLDGS-NSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTK 225

Query: 490 PEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRV 549
            E++   K +  + G+      A+  A    F +S G R E    + LV++  G S D  
Sbjct: 226 EEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPE--AARLLVVVTDGESHDGE 283

Query: 550 DGPAS 554
           + PA+
Sbjct: 284 ELPAA 288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,546,386
Number of Sequences: 37866
Number of extensions: 1612877
Number of successful extensions: 4292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3331
Number of HSP's gapped (non-prelim): 342
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.