Search of human proteins with 240255540

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
sapiens]
         (1237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo ...  2381   0.0  
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s...  2355   0.0  
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s...  2293   0.0  
gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo ...  1936   0.0  
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ...  1292   0.0  
gi|156616290 collagen type VI alpha 6 [Homo sapiens]                  436   e-122
gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]              393   e-109
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]        174   6e-43
gi|21359974 vitrin [Homo sapiens]                                     155   2e-37
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]        142   2e-33
gi|205277471 cochlin precursor [Homo sapiens]                         140   1e-32
gi|4758022 cochlin precursor [Homo sapiens]                           140   1e-32
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]             132   2e-30
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [...   132   2e-30
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]               129   2e-29
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                129   2e-29
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ...   119   1e-26
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]                111   5e-24
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa...   110   1e-23
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             107   5e-23
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             107   5e-23
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          99   2e-20
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]              96   2e-19
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]              96   2e-19
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]       93   2e-18
gi|11321565 matrilin 3 precursor [Homo sapiens]                        88   4e-17
gi|40068485 von Willebrand factor A domain containing 1 isoform ...    77   1e-13
gi|31657142 integrin, alpha 1 precursor [Homo sapiens]                 74   1e-12
gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens]        72   4e-12
gi|38569398 integrin, alpha 10 precursor [Homo sapiens]                69   4e-11

>gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
            sapiens]
          Length = 1237

 Score = 2381 bits (6171), Expect = 0.0
 Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV 60

Query: 61   NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL 120
            NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL
Sbjct: 61   NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL 120

Query: 121  DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR 180
            DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR
Sbjct: 121  DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR 180

Query: 181  AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI 240
            AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI
Sbjct: 181  AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI 240

Query: 241  VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR 300
            VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR
Sbjct: 241  VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR 300

Query: 301  EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS 360
            EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS
Sbjct: 301  EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS 360

Query: 361  QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT 420
            QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT
Sbjct: 361  QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT 420

Query: 421  LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT 480
            LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT
Sbjct: 421  LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT 480

Query: 481  PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL 540
            PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL
Sbjct: 481  PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL 540

Query: 541  LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP 600
            LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP
Sbjct: 541  LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP 600

Query: 601  ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 660
            ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL
Sbjct: 601  ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 660

Query: 661  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 720
            NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY
Sbjct: 661  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 720

Query: 721  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780
            IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI
Sbjct: 721  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780

Query: 781  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL 840
            VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL
Sbjct: 781  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL 840

Query: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900
            LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP
Sbjct: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900

Query: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960
            NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG
Sbjct: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960

Query: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020
            IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP
Sbjct: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020

Query: 1021 GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL 1080
            GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL
Sbjct: 1021 GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL 1080

Query: 1081 NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
            NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG
Sbjct: 1081 NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140

Query: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 1200
            KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT
Sbjct: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 1200

Query: 1201 PITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1237
            PITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI
Sbjct: 1201 PITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1237


>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
            sapiens]
          Length = 2971

 Score = 2355 bits (6102), Expect = 0.0
 Identities = 1224/1232 (99%), Positives = 1228/1232 (99%), Gaps = 1/1232 (0%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV 60
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLV 60

Query: 61   NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL 120
            NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL
Sbjct: 61   NLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLAL 120

Query: 121  DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR 180
            DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR
Sbjct: 121  DFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASR 180

Query: 181  AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI 240
            AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI
Sbjct: 181  AELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDI 240

Query: 241  VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR 300
            VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR
Sbjct: 241  VFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKR 300

Query: 301  EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS 360
            EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS
Sbjct: 301  EVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEIS 360

Query: 361  QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT 420
            QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT
Sbjct: 361  QPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRT 420

Query: 421  LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT 480
            LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT
Sbjct: 421  LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDT 480

Query: 481  PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL 540
            PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL
Sbjct: 481  PVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQL 540

Query: 541  LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP 600
            LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP
Sbjct: 541  LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP 600

Query: 601  ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 660
            ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL
Sbjct: 601  ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 660

Query: 661  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 720
            NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY
Sbjct: 661  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 720

Query: 721  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780
            IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI
Sbjct: 721  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780

Query: 781  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL 840
            VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL
Sbjct: 781  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPL 840

Query: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900
            LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP
Sbjct: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900

Query: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960
            NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG
Sbjct: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960

Query: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020
            IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP
Sbjct: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020

Query: 1021 GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL 1080
            GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL
Sbjct: 1021 GVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLL 1080

Query: 1081 NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
            NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG
Sbjct: 1081 NAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140

Query: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 1200
            KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT
Sbjct: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 1200

Query: 1201 PITTLTSEQIQKLLASTRYPPPG-EMGASEVL 1231
            PITTLTSEQIQKLLASTRYPPP  E  A++++
Sbjct: 1201 PITTLTSEQIQKLLASTRYPPPAVESDAADIV 1232



 Score =  797 bits (2059), Expect = 0.0
 Identities = 476/1212 (39%), Positives = 703/1212 (58%), Gaps = 54/1212 (4%)

Query: 17   LSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVG 76
            LSG P  H+ ++       DIIFL+DGS N G  NF  + DF++NL+  L IG   IRVG
Sbjct: 421  LSGTPEVHSNKR-------DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVG 473

Query: 77   VVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRV 136
            +VQFSD P T FSL+TY TK+ +LG ++ L   GG   N G AL +V  NHFT AGGSR+
Sbjct: 474  LVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRI 533

Query: 137  EEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTV 196
             E VPQ+L+L++AG S D       AL +A + +F +GA  A++AEL+ IA + +LV+ +
Sbjct: 534  REHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM 593

Query: 197  PEFRSFGDLQEKLLP----YIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGL 252
             +F S   L ++L+     Y+ G  +   + +P +         KRDI+FL DGS+ L +
Sbjct: 594  DDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPES---------KRDILFLFDGSANL-V 643

Query: 253  ANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPL 312
              F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F+ H +K E++  V++MK  
Sbjct: 644  GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIK 703

Query: 313  DGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIM 372
             G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G+S D +  PA  LK+S ++
Sbjct: 704  TGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVV 763

Query: 373  AFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTL-SGTPEVHSNK 431
             F    K AD AELE+I    S  FI A      +  + P ++  L+++ +G P   S +
Sbjct: 764  PFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGE 821

Query: 432  RDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQ 491
            +D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV +VQ+SD    EF LN+Y 
Sbjct: 822  KDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYM 880

Query: 492  TKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED 551
             K D++  +RQL L GG   NTG+AL +V  N    + GSRI E VPQLL++LTA +S D
Sbjct: 881  NKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGD 940

Query: 552  SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLT 611
                 +  + R G +   +G   A+  E++ I+F P     +  F  L  + Q + + +T
Sbjct: 941  DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVT 1000

Query: 612  TYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKP 664
                  +  + P+ QP        KRD++FL DGS +   +F  VR  + +++D L+V  
Sbjct: 1001 QLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGF 1060

Query: 665  EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 724
            + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G+ +N+G AL+Y  R IF +
Sbjct: 1061 DTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKR 1120

Query: 725  SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
              GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF   A+NAD  EL +I LSP
Sbjct: 1121 PLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179

Query: 785  AFILAAESLPKIGDLHP------------QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSE 832
             ++ +  +  ++  L              QI  LL S     PA  S   D+VFL+D SE
Sbjct: 1180 EYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSE 1239

Query: 833  GVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 891
            GVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   PEFYL +Y ++  V++A+R+
Sbjct: 1240 GVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRR 1299

Query: 892  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 951
            L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L+++   +S DDV   + V++ 
Sbjct: 1300 LRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRS 1359

Query: 952  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1011
             G V +G+G  N D TE+QTI+  P     +  FR+L  ++    ER+        +   
Sbjct: 1360 SGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE----ERIMNSFGPSAATPA 1415

Query: 1012 P--VLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVI 1068
            P  V  P PS     K D+VFL+DGS       FQ V   +  +VD +    D+ +V ++
Sbjct: 1416 PPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLV 1475

Query: 1069 QFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE 1128
            Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    LE++  N F    GSR+++
Sbjct: 1476 QYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQ 1535

Query: 1129 GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVST 1187
             VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D EE+ KI+ +    F V  
Sbjct: 1536 RVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGN 1595

Query: 1188 FRELPSLEQKLL 1199
             +EL  L +++L
Sbjct: 1596 VQELSELSEQVL 1607



 Score =  550 bits (1418), Expect = e-156
 Identities = 345/1041 (33%), Positives = 558/1041 (53%), Gaps = 62/1041 (5%)

Query: 32   QDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLD 91
            +   DI+FL DGS N     F V+ DFL  ++++L +  +  R+ V Q+SD+ +     D
Sbjct: 627  ESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685

Query: 92   TYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGP 151
             + +K ++L  VK +    G+  N+G ALD+     F ++ GSR+E+GV Q LVL+ AG 
Sbjct: 686  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745

Query: 152  SSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLP 211
            SSD +      LKQ+ V  F   A+ A  AEL+ I      +         GDL  +++ 
Sbjct: 746  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 805

Query: 212  YIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEI 271
             +  V         P  V+      ++D+VFL+DGS  +  + F  +++F+ +V++ L++
Sbjct: 806  LLKSVHNG-----APAPVS-----GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDV 854

Query: 272  GQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLF 331
            GQD ++VAV QY+D  RPEFY N++  K++V+ AVR++  L G    TG+AL+FV  N+ 
Sbjct: 855  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 914

Query: 332  TSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAF 391
             SSAG R  EG+P+LL+++T  +S D++  P+  +KR   +   IG   AD  E++ I+F
Sbjct: 915  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISF 974

Query: 392  DSSL-VFIPAEFRAAPLQGMLP-----------GLLAPLRTLSGTPEVHSNKRDIIFLLD 439
                 V IP   +   +Q ++              L P+     +P V   KRD++FL+D
Sbjct: 975  IPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLID 1033

Query: 440  GSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGH 499
            GS + G   F YVR  +  LV+ LD+G D  RV ++QFSD P  EF LN + +K ++   
Sbjct: 1034 GSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNA 1092

Query: 500  LRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANA 559
            +++L+ +GG  +N G+AL YV  N F    GSRI E VPQ L+L+++G+S+D     A  
Sbjct: 1093 VQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVE 1152

Query: 560  LTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVE 619
            L + G+  F + A  A++ EL +I+ +P  V+ +  F  LP+L Q+L+ P+TT  S  ++
Sbjct: 1153 LKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQ 1211

Query: 620  EV-------PLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAV 671
            ++       P A      DI+FL D S  +    F  +RDF+ +I+  LN+ P   R+ V
Sbjct: 1212 KLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGV 1271

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
             Q+S+DV  E     ++S+  +L+ ++R++++ G  LN G AL++  R +FVKSAGSRIE
Sbjct: 1272 VQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIE 1331

Query: 732  DGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
            DGV Q LVL++ G+S D V   A  ++ SG+V      +N D  EL+ I   P  +    
Sbjct: 1332 DGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVR 1391

Query: 792  SLPKIGDLHPQIVNLL-KSVHNGAPA---------PVSGEKDVVFLLDGSEGVR-SGFPL 840
               ++ ++  +I+N    S    AP          P   + D+VFLLDGS   R   F  
Sbjct: 1392 EFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQE 1451

Query: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900
            +  FV  +V+++    D ++V +VQY+     EF+L  +  K+ +++A+ ++   GG   
Sbjct: 1452 VLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHA 1511

Query: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960
            NT   LE +  N  V  AGSR+ + VPQ+  V+T  +S +D ++ S+ + + G     +G
Sbjct: 1512 NTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVG 1571

Query: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020
            + N D  E+  I      A    T  ++G VQ+     +++L+ + L  L   +     P
Sbjct: 1572 VRNIDSEEVGKI------ASNSATAFRVGNVQE-----LSELSEQVLETLHDAMHETLCP 1620

Query: 1021 GV-----GGKRDVVFLIDGSQ 1036
            GV         DV+   DGS+
Sbjct: 1621 GVTDAAKACNLDVILGFDGSR 1641



 Score =  378 bits (971), Expect = e-104
 Identities = 265/819 (32%), Positives = 412/819 (50%), Gaps = 43/819 (5%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
            D++FLIDGS + G   F  +   +  L++ L +G    RV V+QFSD+P+  F L+ +S+
Sbjct: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085

Query: 96   KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
            K +V  AV+ L   GG   N+G AL++V  N F R  GSR+EEGVPQ LVLIS+G S DE
Sbjct: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145

Query: 156  IRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVG 215
            +    V LKQ  V  F + A+ A + EL  I+     VF+V  FR    L++KLL  I  
Sbjct: 1146 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITT 1204

Query: 216  VAQRHI--VLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQ 273
            +    I  +L         +E +  DIVFL+D S  +    F  IRDF++++++RL IG 
Sbjct: 1205 LTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGP 1264

Query: 274  DLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTS 333
              ++V V Q+++ V PEFY  T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  
Sbjct: 1265 SKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVK 1324

Query: 334  SAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDS 393
            SAG R  +G+P+ LVL+ GGKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D 
Sbjct: 1325 SAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDP 1384

Query: 394  SLVFIPAEFRAAP------LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANV 444
             LVF   EFR  P      +    P    P      TP        K DI+FLLDGS N 
Sbjct: 1385 RLVFTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINF 1444

Query: 445  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 504
             + +F  V  FV  +V+++    D+I+VGLVQ++  P  EF L  + TK  I+  + ++ 
Sbjct: 1445 RRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVV 1504

Query: 505  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 564
             +GG   NT   L ++  NHF    GSR+ + VPQ+  ++T G+S +     + ALT+ G
Sbjct: 1505 YKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRG 1564

Query: 565  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPL 623
            +  F VG    +  E+ +IA N +  + + +   L  L +Q+++ L   +   +   V  
Sbjct: 1565 VKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTD 1624

Query: 624  AQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAV 671
            A      D++  FDGS +    F   + F  K+   LN       V   G      R++V
Sbjct: 1625 AAKACNLDVILGFDGSRD-QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1683

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
               +    VE+ FD  + +PE+L   + M+ +        Y L      +++        
Sbjct: 1684 VANTPSGPVEA-FDFDEYQPEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSP 1736

Query: 732  DGVLQFLVLLVAGRSSDRVD--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI 787
            D V + ++    G   D  D    + NL+Q GV   I     +  +   L  +     F+
Sbjct: 1737 DSV-KVVIHFTDGADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFM 1795

Query: 788  ----LAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEK 822
                L    L    +L  Q+ N+ +    G P   SG++
Sbjct: 1796 YDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGQR 1834



 Score =  229 bits (585), Expect = 9e-60
 Identities = 163/527 (30%), Positives = 259/527 (49%), Gaps = 38/527 (7%)

Query: 33   DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 92
            D+ADI+FLID S       FA I DF+  ++ +L IG  ++RVGVVQFS++    F L T
Sbjct: 1227 DAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKT 1286

Query: 93   YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 152
            Y ++A VL A++ L   GG   N G AL+FV  N F ++ GSR+E+GVPQ LVL+  G S
Sbjct: 1287 YRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKS 1346

Query: 153  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLL-- 210
             D++      ++ + + S G+G +   R ELQ I  D  LVFTV EFR   +++E+++  
Sbjct: 1347 QDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNS 1406

Query: 211  --PYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
              P     A   +   PP+      E  K DIVFL+DGS      +F  +  F+++++  
Sbjct: 1407 FGPSAATPAPPGVDTPPPSRP----EKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDT 1462

Query: 269  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
            +    D IQV + QY      EF+     TKR++I A+ K+    G    T   L+ +R 
Sbjct: 1463 VYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRV 1522

Query: 329  NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 388
            N F   AG R  + +P++  +ITGGKS+++    +  L +  +  FA+G +  D  E+ +
Sbjct: 1523 NHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGK 1582

Query: 389  IAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFLL 438
            IA +S+       FR   +Q +       L TL            T    +   D+I   
Sbjct: 1583 IASNSA-----TAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGF 1637

Query: 439  DGSAN----VGKTNFPYVRDFVMNLVNSLDI------GNDNIRVGLVQFSDT-PVTEFSL 487
            DGS +    V +  F    D ++N ++ +         +  +RV +V  + + PV  F  
Sbjct: 1638 DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEAFDF 1697

Query: 488  NTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
            + YQ   ++L   R ++ Q    L   +    VY N F ++    ++
Sbjct: 1698 DEYQ--PEMLEKFRNMRSQHPYVLTEDTL--KVYLNKFRQSSPDSVK 1740



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 622  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 676
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 2187 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 2246

Query: 677  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 2247 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 2301

Query: 736  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 2302 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 2360

Query: 792  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 830
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 2361 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2420

Query: 831  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 873
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2421 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2480

Query: 874  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 932
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2481 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2539

Query: 933  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 977
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2540 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2585



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 52/370 (14%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQI----RVGVVQFSDEPRTMFSLD 91
            ++ F +D S       F  + D +++++  L I         RV VV +++E  T     
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 92   TYSTKAQVLGAVKALGFA-GGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAG 150
                K+ +L  +K L  A   +  ++  A+ FV  N F R     +   + +V V  S  
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFL---MRKVAVFFSNT 2312

Query: 151  PS--SDEIRYGVVALKQASVFSFGL----GAQAASRAELQHIATDDNLVFTVPEFRSFGD 204
            P+  S ++R  V+ L  A +    L      Q  +  ++ + A    LV  +P  R   D
Sbjct: 2313 PTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV--LPAGRDLTD 2370

Query: 205  LQEKLLPYIV-----------GVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLA 253
              E +L   V           G        +        +++   D+ F++D +    L 
Sbjct: 2371 FLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDI---DMAFILDSAETTTLF 2427

Query: 254  NFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT----------VRPEFYFNTHP 297
             FN ++ +IA ++++L++  D        +VAV Q+A +          V+ EF    + 
Sbjct: 2428 QFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYG 2487

Query: 298  TKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            +K +++  + R M  L G+    GSA+++   N+F S+   R      K++VL+  G+  
Sbjct: 2488 SKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL----KIVVLMLTGEVP 2542

Query: 357  DEISQPAQEL 366
            ++  + AQ +
Sbjct: 2543 EQQLEEAQRV 2552



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 488
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 489  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 547
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 2314

Query: 548  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 594
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 2315 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 2374

Query: 595  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 651
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 2375 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2434

Query: 652  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 695
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2435 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2494

Query: 696  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 744
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2495 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2539



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 294
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 295  THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 350
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 2310

Query: 351  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 405
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 2311 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 2366

Query: 406  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 446
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 2367 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2426

Query: 447  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 490
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2427 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2486

Query: 491  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2487 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2541

Query: 549  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 602
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2542 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2601

Query: 603  P 603
            P
Sbjct: 2602 P 2602



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 1081
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 2196 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2255

Query: 1082 AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 2256 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 2314

Query: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQE 1170
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 2315 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 2344


>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
            sapiens]
          Length = 3177

 Score = 2293 bits (5942), Expect = 0.0
 Identities = 1195/1210 (98%), Positives = 1200/1210 (99%), Gaps = 1/1210 (0%)

Query: 23   THAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSD 82
            T   +   AQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSD
Sbjct: 229  TETLKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSD 288

Query: 83   EPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQ 142
            EPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQ
Sbjct: 289  EPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQ 348

Query: 143  VLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSF 202
            VLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSF
Sbjct: 349  VLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSF 408

Query: 203  GDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFI 262
            GDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFI
Sbjct: 409  GDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFI 468

Query: 263  AKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSA 322
            AKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSA
Sbjct: 469  AKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSA 528

Query: 323  LDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGAD 382
            LDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGAD
Sbjct: 529  LDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGAD 588

Query: 383  QAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSA 442
            QAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSA
Sbjct: 589  QAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSA 648

Query: 443  NVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQ 502
            NVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQ
Sbjct: 649  NVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQ 708

Query: 503  LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTR 562
            LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTR
Sbjct: 709  LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTR 768

Query: 563  AGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVP 622
            AGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVP
Sbjct: 769  AGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVP 828

Query: 623  LAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVES 682
            LAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVES
Sbjct: 829  LAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVES 888

Query: 683  RFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLV 742
            RFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLV
Sbjct: 889  RFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLV 948

Query: 743  AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQ 802
            AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQ
Sbjct: 949  AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQ 1008

Query: 803  IVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVA 862
            IVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVA
Sbjct: 1009 IVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVA 1068

Query: 863  VVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI 922
            VVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI
Sbjct: 1069 VVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI 1128

Query: 923  TEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAI 982
            TEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAI
Sbjct: 1129 TEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAI 1188

Query: 983  PTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF 1042
            PTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF
Sbjct: 1189 PTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF 1248

Query: 1043 QYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGR 1102
            QYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGR
Sbjct: 1249 QYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGR 1308

Query: 1103 QINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFT 1162
            QINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFT
Sbjct: 1309 QINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFT 1368

Query: 1163 IARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP 1222
            IARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP
Sbjct: 1369 IARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP 1428

Query: 1223 G-EMGASEVL 1231
              E  A++++
Sbjct: 1429 AVESDAADIV 1438



 Score =  797 bits (2059), Expect = 0.0
 Identities = 476/1212 (39%), Positives = 703/1212 (58%), Gaps = 54/1212 (4%)

Query: 17   LSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVG 76
            LSG P  H+ ++       DIIFL+DGS N G  NF  + DF++NL+  L IG   IRVG
Sbjct: 627  LSGTPEVHSNKR-------DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVG 679

Query: 77   VVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRV 136
            +VQFSD P T FSL+TY TK+ +LG ++ L   GG   N G AL +V  NHFT AGGSR+
Sbjct: 680  LVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRI 739

Query: 137  EEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTV 196
             E VPQ+L+L++AG S D       AL +A + +F +GA  A++AEL+ IA + +LV+ +
Sbjct: 740  REHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM 799

Query: 197  PEFRSFGDLQEKLLP----YIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGL 252
             +F S   L ++L+     Y+ G  +   + +P +         KRDI+FL DGS+ L +
Sbjct: 800  DDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPES---------KRDILFLFDGSANL-V 849

Query: 253  ANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPL 312
              F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F+ H +K E++  V++MK  
Sbjct: 850  GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIK 909

Query: 313  DGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIM 372
             G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G+S D +  PA  LK+S ++
Sbjct: 910  TGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVV 969

Query: 373  AFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTL-SGTPEVHSNK 431
             F    K AD AELE+I    S  FI A      +  + P ++  L+++ +G P   S +
Sbjct: 970  PFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGE 1027

Query: 432  RDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQ 491
            +D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV +VQ+SD    EF LN+Y 
Sbjct: 1028 KDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYM 1086

Query: 492  TKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED 551
             K D++  +RQL L GG   NTG+AL +V  N    + GSRI E VPQLL++LTA +S D
Sbjct: 1087 NKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGD 1146

Query: 552  SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLT 611
                 +  + R G +   +G   A+  E++ I+F P     +  F  L  + Q + + +T
Sbjct: 1147 DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVT 1206

Query: 612  TYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKP 664
                  +  + P+ QP        KRD++FL DGS +   +F  VR  + +++D L+V  
Sbjct: 1207 QLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGF 1266

Query: 665  EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 724
            + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G+ +N+G AL+Y  R IF +
Sbjct: 1267 DTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKR 1326

Query: 725  SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
              GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF   A+NAD  EL +I LSP
Sbjct: 1327 PLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1385

Query: 785  AFILAAESLPKIGDLHP------------QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSE 832
             ++ +  +  ++  L              QI  LL S     PA  S   D+VFL+D SE
Sbjct: 1386 EYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSE 1445

Query: 833  GVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 891
            GVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   PEFYL +Y ++  V++A+R+
Sbjct: 1446 GVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRR 1505

Query: 892  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 951
            L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L+++   +S DDV   + V++ 
Sbjct: 1506 LRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRS 1565

Query: 952  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1011
             G V +G+G  N D TE+QTI+  P     +  FR+L  ++    ER+        +   
Sbjct: 1566 SGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE----ERIMNSFGPSAATPA 1621

Query: 1012 P--VLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVI 1068
            P  V  P PS     K D+VFL+DGS       FQ V   +  +VD +    D+ +V ++
Sbjct: 1622 PPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLV 1681

Query: 1069 QFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE 1128
            Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    LE++  N F    GSR+++
Sbjct: 1682 QYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQ 1741

Query: 1129 GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVST 1187
             VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D EE+ KI+ +    F V  
Sbjct: 1742 RVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGN 1801

Query: 1188 FRELPSLEQKLL 1199
             +EL  L +++L
Sbjct: 1802 VQELSELSEQVL 1813



 Score =  794 bits (2050), Expect = 0.0
 Identities = 473/1258 (37%), Positives = 734/1258 (58%), Gaps = 50/1258 (3%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQD---SADIIFLIDGSNNTGSVNFAVILD 57
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA      +ADIIFL+D S   G  +F ++ +
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60

Query: 58   FLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIG 117
            FL ++++ L +G       +VQF+  P T F L+TY TK +VL  +  + + GG     G
Sbjct: 61   FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISNMSYIGG-TNQTG 119

Query: 118  LALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQA 177
              L++++++H T+A GSR  +GVPQV+V+++ G S D +      LK A V  F +G + 
Sbjct: 120  KGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVED 179

Query: 178  ASRAELQHIATD--DNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEV 235
            A    L+ IA++  +  +F +  F S  D+   L+  +             T+   +   
Sbjct: 180  ADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHSSVSPERAGDTETL-KDITAQ 238

Query: 236  NKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNT 295
            +  DI+FL+DGS+  G  NF  I DF+  ++++L IG   I+V V Q++D  R  F  +T
Sbjct: 239  DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 298

Query: 296  HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 355
            + TK +V+ AV+ +    G     G ALDFV  N FT + G R  EG+P++LVLI+ G S
Sbjct: 299  YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 358

Query: 356  LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA-APLQ-GMLPG 413
             DEI      LK++S+ +F +G + A +AEL+ IA D +LVF   EFR+   LQ  +LP 
Sbjct: 359  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPY 418

Query: 414  L---------LAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464
            +         L P   ++   EV  NKRDI+FL+DGS+ +G  NF  +RDF+  ++  L+
Sbjct: 419  IVGVAQRHIVLKPPTIVTQVIEV--NKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLE 476

Query: 465  IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 524
            IG D I+V + Q++DT   EF  NT+ TK +++  +R+++   GS L TGSAL +V  N 
Sbjct: 477  IGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNL 536

Query: 525  FTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 584
            FT + G R  E +P+LL+L+T G+S D   Q A  L R+ I+ F +G   A++AELE+IA
Sbjct: 537  FTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 596

Query: 585  FNPSLVYLMDDFSSLP--ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANL 642
            F+ SLV++  +F + P   +   L+ PL T    G  EV      +KRDI+FL DGSAN 
Sbjct: 597  FDSSLVFIPAEFRAAPLQGMLPGLLAPLRTL--SGTPEV----HSNKRDIIFLLDGSAN- 649

Query: 643  VGQ--FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRM 700
            VG+  FP VRDF+  +++ L++  +  R+ + Q+SD    E   + +Q+K +IL  ++++
Sbjct: 650  VGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQL 709

Query: 701  KIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQS 760
            +++ G  LN G AL Y     F ++ GSRI + V Q L+LL AG+S D     A+ L ++
Sbjct: 710  QLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRA 769

Query: 761  GVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPV-- 818
            G++ F   A  A+ AELEQI  +P+ +   +    +  L  Q++  L +  +G    V  
Sbjct: 770  GILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPL 829

Query: 819  ---SGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFY 875
                 ++D++FL DGS  +   FP++++F+ ++++ L+V  +  R+AV QYSD  + E  
Sbjct: 830  AQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESR 889

Query: 876  LNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTA 935
             + + +K +++N V+++ +  G   N G AL++  R I V SAGSRI +GV Q L++L A
Sbjct: 890  FDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA 949

Query: 936  DRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVI 995
             RS D V  P+  +K+ G VP      NAD  E++ I   P F +A  +  ++G +   I
Sbjct: 950  GRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQI 1009

Query: 996  SERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDY 1055
                       ++ L+ V    P+P V G++DVVFL+DGS+     F  ++  ++R+V+ 
Sbjct: 1010 -----------VNLLKSVHNGAPAP-VSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVES 1057

Query: 1056 LDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSR 1115
            LDVG D  RVAV+Q+SD  + EF LN++ +K +V NAV++L   GG   N G ALE+V R
Sbjct: 1058 LDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLR 1117

Query: 1116 NIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVK 1174
            NI     GSRI EGVPQ L+++++ +S D+V +P+V +K+ G  P  I   NAD  E+  
Sbjct: 1118 NILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQT 1177

Query: 1175 ISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTR-YPPPGEMGASEVL 1231
            IS  P++  ++ TFR+L +++Q +   +T LT E++ +L    +  P PG  G  +V+
Sbjct: 1178 ISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVV 1235



 Score =  550 bits (1418), Expect = e-156
 Identities = 345/1041 (33%), Positives = 558/1041 (53%), Gaps = 62/1041 (5%)

Query: 32   QDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLD 91
            +   DI+FL DGS N     F V+ DFL  ++++L +  +  R+ V Q+SD+ +     D
Sbjct: 833  ESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 891

Query: 92   TYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGP 151
             + +K ++L  VK +    G+  N+G ALD+     F ++ GSR+E+GV Q LVL+ AG 
Sbjct: 892  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 951

Query: 152  SSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLP 211
            SSD +      LKQ+ V  F   A+ A  AEL+ I      +         GDL  +++ 
Sbjct: 952  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 1011

Query: 212  YIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEI 271
             +  V         P  V+      ++D+VFL+DGS  +  + F  +++F+ +V++ L++
Sbjct: 1012 LLKSVHNG-----APAPVS-----GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDV 1060

Query: 272  GQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLF 331
            GQD ++VAV QY+D  RPEFY N++  K++V+ AVR++  L G    TG+AL+FV  N+ 
Sbjct: 1061 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 1120

Query: 332  TSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAF 391
             SSAG R  EG+P+LL+++T  +S D++  P+  +KR   +   IG   AD  E++ I+F
Sbjct: 1121 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISF 1180

Query: 392  DSSL-VFIPAEFRAAPLQGMLP-----------GLLAPLRTLSGTPEVHSNKRDIIFLLD 439
                 V IP   +   +Q ++              L P+     +P V   KRD++FL+D
Sbjct: 1181 IPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLID 1239

Query: 440  GSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGH 499
            GS + G   F YVR  +  LV+ LD+G D  RV ++QFSD P  EF LN + +K ++   
Sbjct: 1240 GSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNA 1298

Query: 500  LRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANA 559
            +++L+ +GG  +N G+AL YV  N F    GSRI E VPQ L+L+++G+S+D     A  
Sbjct: 1299 VQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVE 1358

Query: 560  LTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVE 619
            L + G+  F + A  A++ EL +I+ +P  V+ +  F  LP+L Q+L+ P+TT  S  ++
Sbjct: 1359 LKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQ 1417

Query: 620  EV-------PLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAV 671
            ++       P A      DI+FL D S  +    F  +RDF+ +I+  LN+ P   R+ V
Sbjct: 1418 KLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGV 1477

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
             Q+S+DV  E     ++S+  +L+ ++R++++ G  LN G AL++  R +FVKSAGSRIE
Sbjct: 1478 VQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIE 1537

Query: 732  DGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
            DGV Q LVL++ G+S D V   A  ++ SG+V      +N D  EL+ I   P  +    
Sbjct: 1538 DGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVR 1597

Query: 792  SLPKIGDLHPQIVNLL-KSVHNGAPA---------PVSGEKDVVFLLDGSEGVR-SGFPL 840
               ++ ++  +I+N    S    AP          P   + D+VFLLDGS   R   F  
Sbjct: 1598 EFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQE 1657

Query: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900
            +  FV  +V+++    D ++V +VQY+     EF+L  +  K+ +++A+ ++   GG   
Sbjct: 1658 VLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHA 1717

Query: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960
            NT   LE +  N  V  AGSR+ + VPQ+  V+T  +S +D ++ S+ + + G     +G
Sbjct: 1718 NTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVG 1777

Query: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020
            + N D  E+  I      A    T  ++G VQ+     +++L+ + L  L   +     P
Sbjct: 1778 VRNIDSEEVGKI------ASNSATAFRVGNVQE-----LSELSEQVLETLHDAMHETLCP 1826

Query: 1021 GV-----GGKRDVVFLIDGSQ 1036
            GV         DV+   DGS+
Sbjct: 1827 GVTDAAKACNLDVILGFDGSR 1847



 Score =  378 bits (971), Expect = e-104
 Identities = 265/819 (32%), Positives = 412/819 (50%), Gaps = 43/819 (5%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
            D++FLIDGS + G   F  +   +  L++ L +G    RV V+QFSD+P+  F L+ +S+
Sbjct: 1233 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1291

Query: 96   KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
            K +V  AV+ L   GG   N+G AL++V  N F R  GSR+EEGVPQ LVLIS+G S DE
Sbjct: 1292 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1351

Query: 156  IRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVG 215
            +    V LKQ  V  F + A+ A + EL  I+     VF+V  FR    L++KLL  I  
Sbjct: 1352 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITT 1410

Query: 216  VAQRHI--VLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQ 273
            +    I  +L         +E +  DIVFL+D S  +    F  IRDF++++++RL IG 
Sbjct: 1411 LTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGP 1470

Query: 274  DLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTS 333
              ++V V Q+++ V PEFY  T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  
Sbjct: 1471 SKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVK 1530

Query: 334  SAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDS 393
            SAG R  +G+P+ LVL+ GGKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D 
Sbjct: 1531 SAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDP 1590

Query: 394  SLVFIPAEFRAAP------LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANV 444
             LVF   EFR  P      +    P    P      TP        K DI+FLLDGS N 
Sbjct: 1591 RLVFTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINF 1650

Query: 445  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 504
             + +F  V  FV  +V+++    D+I+VGLVQ++  P  EF L  + TK  I+  + ++ 
Sbjct: 1651 RRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVV 1710

Query: 505  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 564
             +GG   NT   L ++  NHF    GSR+ + VPQ+  ++T G+S +     + ALT+ G
Sbjct: 1711 YKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRG 1770

Query: 565  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPL 623
            +  F VG    +  E+ +IA N +  + + +   L  L +Q+++ L   +   +   V  
Sbjct: 1771 VKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTD 1830

Query: 624  AQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAV 671
            A      D++  FDGS +    F   + F  K+   LN       V   G      R++V
Sbjct: 1831 AAKACNLDVILGFDGSRD-QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1889

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
               +    VE+ FD  + +PE+L   + M+ +        Y L      +++        
Sbjct: 1890 VANTPSGPVEA-FDFDEYQPEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSP 1942

Query: 732  DGVLQFLVLLVAGRSSDRVD--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI 787
            D V + ++    G   D  D    + NL+Q GV   I     +  +   L  +     F+
Sbjct: 1943 DSV-KVVIHFTDGADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFM 2001

Query: 788  ----LAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEK 822
                L    L    +L  Q+ N+ +    G P   SG++
Sbjct: 2002 YDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGQR 2040



 Score =  229 bits (585), Expect = 9e-60
 Identities = 163/527 (30%), Positives = 259/527 (49%), Gaps = 38/527 (7%)

Query: 33   DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 92
            D+ADI+FLID S       FA I DF+  ++ +L IG  ++RVGVVQFS++    F L T
Sbjct: 1433 DAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKT 1492

Query: 93   YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 152
            Y ++A VL A++ L   GG   N G AL+FV  N F ++ GSR+E+GVPQ LVL+  G S
Sbjct: 1493 YRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKS 1552

Query: 153  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLL-- 210
             D++      ++ + + S G+G +   R ELQ I  D  LVFTV EFR   +++E+++  
Sbjct: 1553 QDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNS 1612

Query: 211  --PYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
              P     A   +   PP+      E  K DIVFL+DGS      +F  +  F+++++  
Sbjct: 1613 FGPSAATPAPPGVDTPPPSRP----EKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDT 1668

Query: 269  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
            +    D IQV + QY      EF+     TKR++I A+ K+    G    T   L+ +R 
Sbjct: 1669 VYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRV 1728

Query: 329  NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 388
            N F   AG R  + +P++  +ITGGKS+++    +  L +  +  FA+G +  D  E+ +
Sbjct: 1729 NHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGK 1788

Query: 389  IAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFLL 438
            IA +S+       FR   +Q +       L TL            T    +   D+I   
Sbjct: 1789 IASNSA-----TAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGF 1843

Query: 439  DGSAN----VGKTNFPYVRDFVMNLVNSLDI------GNDNIRVGLVQFSDT-PVTEFSL 487
            DGS +    V +  F    D ++N ++ +         +  +RV +V  + + PV  F  
Sbjct: 1844 DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEAFDF 1903

Query: 488  NTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
            + YQ   ++L   R ++ Q    L   +    VY N F ++    ++
Sbjct: 1904 DEYQ--PEMLEKFRNMRSQHPYVLTEDTL--KVYLNKFRQSSPDSVK 1946



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 622  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 676
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 2393 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 2452

Query: 677  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 2453 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 2507

Query: 736  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 2508 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 2566

Query: 792  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 830
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 2567 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2626

Query: 831  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 873
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2627 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2686

Query: 874  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 932
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2687 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2745

Query: 933  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 977
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2746 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2791



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 52/370 (14%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQI----RVGVVQFSDEPRTMFSLD 91
            ++ F +D S       F  + D +++++  L I         RV VV +++E  T     
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 92   TYSTKAQVLGAVKALGFA-GGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAG 150
                K+ +L  +K L  A   +  ++  A+ FV  N F R     +   + +V V  S  
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFL---MRKVAVFFSNT 2518

Query: 151  PS--SDEIRYGVVALKQASVFSFGL----GAQAASRAELQHIATDDNLVFTVPEFRSFGD 204
            P+  S ++R  V+ L  A +    L      Q  +  ++ + A    LV  +P  R   D
Sbjct: 2519 PTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV--LPAGRDLTD 2576

Query: 205  LQEKLLPYIV-----------GVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLA 253
              E +L   V           G        +        +++   D+ F++D +    L 
Sbjct: 2577 FLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDI---DMAFILDSAETTTLF 2633

Query: 254  NFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT----------VRPEFYFNTHP 297
             FN ++ +IA ++++L++  D        +VAV Q+A +          V+ EF    + 
Sbjct: 2634 QFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYG 2693

Query: 298  TKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            +K +++  + R M  L G+    GSA+++   N+F S+   R      K++VL+  G+  
Sbjct: 2694 SKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL----KIVVLMLTGEVP 2748

Query: 357  DEISQPAQEL 366
            ++  + AQ +
Sbjct: 2749 EQQLEEAQRV 2758



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 488
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 489  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 547
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 2520

Query: 548  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 594
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 2521 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 2580

Query: 595  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 651
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 2581 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2640

Query: 652  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 695
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2641 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2700

Query: 696  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 744
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2701 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2745



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 294
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 295  THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 350
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 2516

Query: 351  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 405
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 2517 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 2572

Query: 406  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 446
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 2573 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2632

Query: 447  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 490
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2633 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2692

Query: 491  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2693 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2747

Query: 549  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 602
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2748 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2807

Query: 603  P 603
            P
Sbjct: 2808 P 2808



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 1081
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 2402 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 2461

Query: 1082 AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 2462 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 2520

Query: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQE 1170
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 2521 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 2550


>gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
            sapiens]
          Length = 1036

 Score = 1936 bits (5016), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 232  VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 291
            VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF
Sbjct: 31   VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 90

Query: 292  YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 351
            YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT
Sbjct: 91   YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 150

Query: 352  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 411
            GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML
Sbjct: 151  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 210

Query: 412  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 471
            PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR
Sbjct: 211  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 270

Query: 472  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 531
            VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS
Sbjct: 271  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 330

Query: 532  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 591
            RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY
Sbjct: 331  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 390

Query: 592  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 651
            LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD
Sbjct: 391  LMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRD 450

Query: 652  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 711
            FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG
Sbjct: 451  FLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLG 510

Query: 712  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 771
            YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN
Sbjct: 511  YALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKN 570

Query: 772  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 831
            ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS
Sbjct: 571  ADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGS 630

Query: 832  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 891
            EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ
Sbjct: 631  EGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQ 690

Query: 892  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 951
            LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR
Sbjct: 691  LTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKR 750

Query: 952  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 1011
            GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ
Sbjct: 751  GGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQ 810

Query: 1012 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 1071
            PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS
Sbjct: 811  PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFS 870

Query: 1072 DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 1131
            DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP
Sbjct: 871  DDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVP 930

Query: 1132 QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 1191
            QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL
Sbjct: 931  QFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFREL 990

Query: 1192 PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1237
            PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI
Sbjct: 991  PSLEQKLLTPITTLTSEQIQKLLASTRYPPPGEMGASEVLLGAFSI 1036



 Score =  695 bits (1794), Expect = 0.0
 Identities = 411/1052 (39%), Positives = 628/1052 (59%), Gaps = 45/1052 (4%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQD--SADIIFLIDGSNNTGSVNFAVILDF 58
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA  +    DI+FL+DGS+  G  NF  I DF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60

Query: 59   LVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGL 118
            +  ++++L IG   I+V V Q++D  R  F  +T+ TK +V+ AV+ +    G     G 
Sbjct: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120

Query: 119  ALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAA 178
            ALDFV  N FT + G R  EG+P++LVLI+ G S DEI      LK++S+ +F +G + A
Sbjct: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180

Query: 179  SRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEV--N 236
             +AEL+ IA D +LVF   EFR+   LQ  +LP +         L P   ++   EV  N
Sbjct: 181  DQAELEEIAFDSSLVFIPAEFRA-APLQ-GMLPGL---------LAPLRTLSGTPEVHSN 229

Query: 237  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296
            KRDI+FL+DGS+ +G  NF  +RDF+  ++  L+IG D I+V + Q++DT   EF  NT+
Sbjct: 230  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 289

Query: 297  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
             TK +++  +R+++   GS L TGSAL +V  N FT + G R  E +P+LL+L+T G+S 
Sbjct: 290  QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 349

Query: 357  DEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLA 416
            D   Q A  L R+ I+ F +G   A++AELE+IAF+ SLV++  +F + P   +   L+ 
Sbjct: 350  DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLP--ALPQQLIQ 407

Query: 417  PLRTL--SGTPEV----HSNKRDIIFLLDGSAN-VGKTNFPYVRDFVMNLVNSLDIGNDN 469
            PL T    G  EV      +KRDI+FL DGSAN VG+  FP VRDF+  +++ L++  + 
Sbjct: 408  PLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ--FPVVRDFLYKIIDELNVKPEG 465

Query: 470  IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 529
             R+ + Q+SD    E   + +Q+K +IL  +++++++ G  LN G AL Y     F ++ 
Sbjct: 466  TRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSA 525

Query: 530  GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL 589
            GSRI + V Q L+LL AG+S D     A+ L ++G++ F   A  A+ AELEQI  +P+ 
Sbjct: 526  GSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAF 585

Query: 590  VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVV 649
            +   +    +  L  Q++  L +  +G    V       ++D++FL DGS  +   FP++
Sbjct: 586  ILAAESLPKIGDLHPQIVNLLKSVHNGAPAPV-----SGEKDVVFLLDGSEGVRSGFPLL 640

Query: 650  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 709
            ++F+ ++++ L+V  +  R+AV QYSD  + E   + + +K +++N V+++ +  G   N
Sbjct: 641  KEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPN 700

Query: 710  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 769
             G AL++  R I V SAGSRI +GV Q L++L A RS D V  P+  +K+ G VP     
Sbjct: 701  TGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGI 760

Query: 770  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQI-----------VNLLKSVHNGAPAP- 817
             NAD  E++ I   P F +A  +  ++G +   I           ++ L+ V    P+P 
Sbjct: 761  GNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPG 820

Query: 818  VSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
            V G++DVVFL+DGS+     F  ++  ++R+V+ LDVG D  RVAV+Q+SD  + EF LN
Sbjct: 821  VGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN 880

Query: 878  SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937
            ++ +K +V NAV++L   GG   N G ALE+V RNI     GSRI EGVPQ L+++++ +
Sbjct: 881  AHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK 940

Query: 938  SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISE 997
            S D+V +P+V +K+ G  P  I   NAD  E+  IS  P++  ++ TFR+L +++Q +  
Sbjct: 941  SDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLT 999

Query: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVV 1029
             +T LT E++ +L    +  P PG  G  +V+
Sbjct: 1000 PITTLTSEQIQKLLASTR-YPPPGEMGASEVL 1030


>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
            sapiens]
          Length = 2570

 Score = 1292 bits (3343), Expect = 0.0
 Identities = 685/823 (83%), Positives = 732/823 (88%), Gaps = 20/823 (2%)

Query: 421  LSGTPEVHS---------NKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIR 471
            LSG P  H+         NKRDI+FL+DGS+ +G  NF  +RDF+  ++  L+IG D I+
Sbjct: 17   LSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQ 76

Query: 472  VGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGS 531
            V + Q++DT   EF  NT+ TK +++  +R+++   GS L TGSAL +V  N FT + G 
Sbjct: 77   VAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGY 136

Query: 532  RIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVY 591
            R  E +P+LL+L+T G+S D   Q A  L R+ I+ F +G   A++AELE+IAF+ SLV+
Sbjct: 137  RAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVF 196

Query: 592  LMDDFSSLP--ALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVV 649
            +  +F + P   +   L+ PL T +SG  EE       SKRDILFLFDGSANLVGQFPVV
Sbjct: 197  IPAEFRAAPLQGMLPGLLAPLRT-LSGTPEE-------SKRDILFLFDGSANLVGQFPVV 248

Query: 650  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 709
            RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN
Sbjct: 249  RDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALN 308

Query: 710  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 769
            LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA
Sbjct: 309  LGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQA 368

Query: 770  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD 829
            KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD
Sbjct: 369  KNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLD 428

Query: 830  GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV 889
            GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV
Sbjct: 429  GSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAV 488

Query: 890  RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV 949
            RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV
Sbjct: 489  RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVV 548

Query: 950  KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR 1009
            KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR
Sbjct: 549  KRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSR 608

Query: 1010 LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ 1069
            LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ
Sbjct: 609  LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQ 668

Query: 1070 FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 1129
            FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG
Sbjct: 669  FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 728

Query: 1130 VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR 1189
            VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR
Sbjct: 729  VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFR 788

Query: 1190 ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG-EMGASEVL 1231
            ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPP  E  A++++
Sbjct: 789  ELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIV 831



 Score =  878 bits (2269), Expect = 0.0
 Identities = 487/983 (49%), Positives = 662/983 (67%), Gaps = 25/983 (2%)

Query: 232  VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 291
            VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF
Sbjct: 31   VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEF 90

Query: 292  YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 351
            YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT
Sbjct: 91   YFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLIT 150

Query: 352  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 411
            GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML
Sbjct: 151  GGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGML 210

Query: 412  PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSAN-VGKTNFPYVRDFVMNLVNSLDIGNDNI 470
            PGLLAPLRTLSGTPE   +KRDI+FL DGSAN VG+  FP VRDF+  +++ L++  +  
Sbjct: 211  PGLLAPLRTLSGTPE--ESKRDILFLFDGSANLVGQ--FPVVRDFLYKIIDELNVKPEGT 266

Query: 471  RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 530
            R+ + Q+SD    E   + +Q+K +IL  +++++++ G  LN G AL Y     F ++ G
Sbjct: 267  RIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAG 326

Query: 531  SRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLV 590
            SRI + V Q L+LL AG+S D     A+ L ++G++ F   A  A+ AELEQI  +P+ +
Sbjct: 327  SRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFI 386

Query: 591  YLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVR 650
               +    +  L  Q++  L +  +G    V       ++D++FL DGS  +   FP+++
Sbjct: 387  LAAESLPKIGDLHPQIVNLLKSVHNGAPAPV-----SGEKDVVFLLDGSEGVRSGFPLLK 441

Query: 651  DFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNL 710
            +F+ ++++ L+V  +  R+AV QYSD  + E   + + +K +++N V+++ +  G   N 
Sbjct: 442  EFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNT 501

Query: 711  GYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAK 770
            G AL++  R I V SAGSRI +GV Q L++L A RS D V  P+  +K+ G VP      
Sbjct: 502  GAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIG 561

Query: 771  NADPAELEQIVLSPAFILAAESLPKIGDLHPQI-----------VNLLKSVHNGAPAP-V 818
            NAD  E++ I   P F +A  +  ++G +   I           ++ L+ V    P+P V
Sbjct: 562  NADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV 621

Query: 819  SGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 878
             G++DVVFL+DGS+     F  ++  ++R+V+ LDVG D  RVAV+Q+SD  + EF LN+
Sbjct: 622  GGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 681

Query: 879  YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRS 938
            + +K +V NAV++L   GG   N G ALE+V RNI     GSRI EGVPQ L+++++ +S
Sbjct: 682  HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 741

Query: 939  GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 998
             D+V +P+V +K+ G  P  I   NAD  E+  IS  P++  ++ TFR+L +++Q +   
Sbjct: 742  DDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTP 800

Query: 999  VTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLD 1057
            +T LT E++ +L    +  P        D+VFLID S+   P+ F ++R  + R+V  L+
Sbjct: 801  ITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLN 860

Query: 1058 VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNI 1117
            +G    RV V+QFS+D   EF L  + S+  V +A++RLR +GG  +N G ALE+V+RN+
Sbjct: 861  IGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNL 920

Query: 1118 FKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKIS 1176
            F +  GSRIE+GVPQ LVL+  GKS D+V   A  ++  G+    +  RN D+ EL  I+
Sbjct: 921  FVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTIT 980

Query: 1177 LSPEYVFSVSTFRELPSLEQKLL 1199
              P  VF+V  FRELP++E++++
Sbjct: 981  NDPRLVFTVREFRELPNIEERIM 1003



 Score =  819 bits (2116), Expect = 0.0
 Identities = 492/1226 (40%), Positives = 717/1226 (58%), Gaps = 47/1226 (3%)

Query: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQD--SADIIFLIDGSNNTGSVNFAVILDF 58
            MRKHRHLPLVAVFCLFLSGFPTTHAQQQQA  +    DI+FL+DGS+  G  NF  I DF
Sbjct: 1    MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDF 60

Query: 59   LVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGL 118
            +  ++++L IG   I+V V Q++D  R  F  +T+ TK +V+ AV+ +    G     G 
Sbjct: 61   IAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGS 120

Query: 119  ALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAA 178
            ALDFV  N FT + G R  EG+P++LVLI+ G S DEI      LK++S+ +F +G + A
Sbjct: 121  ALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGA 180

Query: 179  SRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKR 238
             +AEL+ IA D +LVF   EFR+   LQ  +LP +         L P   ++   E +KR
Sbjct: 181  DQAELEEIAFDSSLVFIPAEFRA-APLQ-GMLPGL---------LAPLRTLSGTPEESKR 229

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
            DI+FL DGS+ L +  F  +RDF+ K+I  L +  +  ++AVAQY+D V+ E  F+ H +
Sbjct: 230  DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 288

Query: 299  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
            K E++  V++MK   G AL  G ALD+ +  +F  SAG R  +G+ + LVL+  G+S D 
Sbjct: 289  KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 348

Query: 359  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPL 418
            +  PA  LK+S ++ F    K AD AELE+I    S  FI A      +  + P ++  L
Sbjct: 349  VDGPASNLKQSGVVPFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIVNLL 406

Query: 419  RTL-SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 477
            +++ +G P   S ++D++FLLDGS  V ++ FP +++FV  +V SLD+G D +RV +VQ+
Sbjct: 407  KSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQY 465

Query: 478  SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 537
            SD    EF LN+Y  K D++  +RQL L GG   NTG+AL +V  N    + GSRI E V
Sbjct: 466  SDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGV 525

Query: 538  PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFS 597
            PQLL++LTA +S D     +  + R G +   +G   A+  E++ I+F P     +  F 
Sbjct: 526  PQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFR 585

Query: 598  SLPALPQQLIQPLTTYVSGGVEEV-PLAQP------ESKRDILFLFDGSANLVGQFPVVR 650
             L  + Q + + +T      +  + P+ QP        KRD++FL DGS +   +F  VR
Sbjct: 586  QLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVR 645

Query: 651  DFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNL 710
              + +++D L+V  + TR+AV Q+SDD KVE   + H SK E+ N V+R++ K G+ +N+
Sbjct: 646  TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 705

Query: 711  GYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAK 770
            G AL+Y  R IF +  GSRIE+GV QFLVL+ +G+S D VD PA  LKQ GV PF   A+
Sbjct: 706  GNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-AR 764

Query: 771  NADPAELEQIVLSPAFILAAESLPKIGDLH------------PQIVNLLKSVHNGAPAPV 818
            NAD  EL +I LSP ++ +  +  ++  L              QI  LL S     PA  
Sbjct: 765  NADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPAVE 824

Query: 819  SGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
            S   D+VFL+D SEGVR  GF  +++FV R+V  L++G  +VRV VVQ+S+   PEFYL 
Sbjct: 825  SDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLK 884

Query: 878  SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937
            +Y ++  V++A+R+L L GG   NTG ALEFV RN+ V SAGSRI +GVPQ L+++   +
Sbjct: 885  TYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGK 944

Query: 938  SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISE 997
            S DDV   + V++  G V +G+G  N D TE+QTI+  P     +  FR+L  ++    E
Sbjct: 945  SQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIE----E 1000

Query: 998  RVTQLTREELSRLQP--VLQPLPSPGVGGKRDVVFLIDGS-QSAGPEFQYVRTLIERLVD 1054
            R+        +   P  V  P PS     K D+VFL+DGS       FQ V   +  +VD
Sbjct: 1001 RIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVD 1060

Query: 1055 YLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVS 1114
             +    D+ +V ++Q++ DP  EF L   S+K ++ +A+ ++  KGGR  N    LE++ 
Sbjct: 1061 TVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLR 1120

Query: 1115 RNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELV 1173
             N F    GSR+++ VPQ   +I+ GKS ++  D ++ L Q GV  F +  RN D EE+ 
Sbjct: 1121 VNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVG 1180

Query: 1174 KISLSPEYVFSVSTFRELPSLEQKLL 1199
            KI+ +    F V   +EL  L +++L
Sbjct: 1181 KIASNSATAFRVGNVQELSELSEQVL 1206



 Score =  550 bits (1418), Expect = e-156
 Identities = 345/1041 (33%), Positives = 558/1041 (53%), Gaps = 62/1041 (5%)

Query: 32   QDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLD 91
            +   DI+FL DGS N     F V+ DFL  ++++L +  +  R+ V Q+SD+ +     D
Sbjct: 226  ESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 284

Query: 92   TYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGP 151
             + +K ++L  VK +    G+  N+G ALD+     F ++ GSR+E+GV Q LVL+ AG 
Sbjct: 285  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 344

Query: 152  SSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLP 211
            SSD +      LKQ+ V  F   A+ A  AEL+ I      +         GDL  +++ 
Sbjct: 345  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 404

Query: 212  YIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEI 271
             +  V         P  V+      ++D+VFL+DGS  +  + F  +++F+ +V++ L++
Sbjct: 405  LLKSVHNG-----APAPVS-----GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDV 453

Query: 272  GQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLF 331
            GQD ++VAV QY+D  RPEFY N++  K++V+ AVR++  L G    TG+AL+FV  N+ 
Sbjct: 454  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 513

Query: 332  TSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAF 391
             SSAG R  EG+P+LL+++T  +S D++  P+  +KR   +   IG   AD  E++ I+F
Sbjct: 514  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISF 573

Query: 392  DSSL-VFIPAEFRAAPLQGMLP-----------GLLAPLRTLSGTPEVHSNKRDIIFLLD 439
                 V IP   +   +Q ++              L P+     +P V   KRD++FL+D
Sbjct: 574  IPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGV-GGKRDVVFLID 632

Query: 440  GSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGH 499
            GS + G   F YVR  +  LV+ LD+G D  RV ++QFSD P  EF LN + +K ++   
Sbjct: 633  GSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNA 691

Query: 500  LRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANA 559
            +++L+ +GG  +N G+AL YV  N F    GSRI E VPQ L+L+++G+S+D     A  
Sbjct: 692  VQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVE 751

Query: 560  LTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVE 619
            L + G+  F + A  A++ EL +I+ +P  V+ +  F  LP+L Q+L+ P+TT  S  ++
Sbjct: 752  LKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTSEQIQ 810

Query: 620  EV-------PLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAV 671
            ++       P A      DI+FL D S  +    F  +RDF+ +I+  LN+ P   R+ V
Sbjct: 811  KLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGV 870

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
             Q+S+DV  E     ++S+  +L+ ++R++++ G  LN G AL++  R +FVKSAGSRIE
Sbjct: 871  VQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIE 930

Query: 732  DGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
            DGV Q LVL++ G+S D V   A  ++ SG+V      +N D  EL+ I   P  +    
Sbjct: 931  DGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVR 990

Query: 792  SLPKIGDLHPQIVNLL-KSVHNGAPA---------PVSGEKDVVFLLDGSEGVR-SGFPL 840
               ++ ++  +I+N    S    AP          P   + D+VFLLDGS   R   F  
Sbjct: 991  EFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQE 1050

Query: 841  LKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTP 900
            +  FV  +V+++    D ++V +VQY+     EF+L  +  K+ +++A+ ++   GG   
Sbjct: 1051 VLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHA 1110

Query: 901  NTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIG 960
            NT   LE +  N  V  AGSR+ + VPQ+  V+T  +S +D ++ S+ + + G     +G
Sbjct: 1111 NTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVG 1170

Query: 961  IGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSP 1020
            + N D  E+  I      A    T  ++G VQ+     +++L+ + L  L   +     P
Sbjct: 1171 VRNIDSEEVGKI------ASNSATAFRVGNVQE-----LSELSEQVLETLHDAMHETLCP 1219

Query: 1021 GV-----GGKRDVVFLIDGSQ 1036
            GV         DV+   DGS+
Sbjct: 1220 GVTDAAKACNLDVILGFDGSR 1240



 Score =  378 bits (971), Expect = e-104
 Identities = 265/819 (32%), Positives = 412/819 (50%), Gaps = 43/819 (5%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
            D++FLIDGS + G   F  +   +  L++ L +G    RV V+QFSD+P+  F L+ +S+
Sbjct: 626  DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 684

Query: 96   KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
            K +V  AV+ L   GG   N+G AL++V  N F R  GSR+EEGVPQ LVLIS+G S DE
Sbjct: 685  KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 744

Query: 156  IRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYIVG 215
            +    V LKQ  V  F + A+ A + EL  I+     VF+V  FR    L++KLL  I  
Sbjct: 745  VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITT 803

Query: 216  VAQRHI--VLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQ 273
            +    I  +L         +E +  DIVFL+D S  +    F  IRDF++++++RL IG 
Sbjct: 804  LTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGP 863

Query: 274  DLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTS 333
              ++V V Q+++ V PEFY  T+ ++  V+ A+R+++   GS L TG AL+FV  NLF  
Sbjct: 864  SKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVK 923

Query: 334  SAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDS 393
            SAG R  +G+P+ LVL+ GGKS D++S+ AQ ++ S I++  +G++  D+ EL+ I  D 
Sbjct: 924  SAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDP 983

Query: 394  SLVFIPAEFRAAP------LQGMLPGLLAPLRTLSGTP---EVHSNKRDIIFLLDGSANV 444
             LVF   EFR  P      +    P    P      TP        K DI+FLLDGS N 
Sbjct: 984  RLVFTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINF 1043

Query: 445  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 504
             + +F  V  FV  +V+++    D+I+VGLVQ++  P  EF L  + TK  I+  + ++ 
Sbjct: 1044 RRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVV 1103

Query: 505  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 564
             +GG   NT   L ++  NHF    GSR+ + VPQ+  ++T G+S +     + ALT+ G
Sbjct: 1104 YKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRG 1163

Query: 565  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGV-EEVPL 623
            +  F VG    +  E+ +IA N +  + + +   L  L +Q+++ L   +   +   V  
Sbjct: 1164 VKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTD 1223

Query: 624  AQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELN-------VKPEG-----TRIAV 671
            A      D++  FDGS +    F   + F  K+   LN       V   G      R++V
Sbjct: 1224 AAKACNLDVILGFDGSRD-QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1282

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
               +    VE+ FD  + +PE+L   + M+ +        Y L      +++        
Sbjct: 1283 VANTPSGPVEA-FDFDEYQPEMLEKFRNMRSQH------PYVLTEDTLKVYLNKFRQSSP 1335

Query: 732  DGVLQFLVLLVAGRSSDRVD--GPASNLKQSGVVPFIFQA--KNADPAELEQIVLSPAFI 787
            D V + ++    G   D  D    + NL+Q GV   I     +  +   L  +     F+
Sbjct: 1336 DSV-KVVIHFTDGADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFM 1394

Query: 788  ----LAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEK 822
                L    L    +L  Q+ N+ +    G P   SG++
Sbjct: 1395 YDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGQR 1433



 Score =  229 bits (585), Expect = 9e-60
 Identities = 163/527 (30%), Positives = 259/527 (49%), Gaps = 38/527 (7%)

Query: 33   DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 92
            D+ADI+FLID S       FA I DF+  ++ +L IG  ++RVGVVQFS++    F L T
Sbjct: 826  DAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKT 885

Query: 93   YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 152
            Y ++A VL A++ L   GG   N G AL+FV  N F ++ GSR+E+GVPQ LVL+  G S
Sbjct: 886  YRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKS 945

Query: 153  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLL-- 210
             D++      ++ + + S G+G +   R ELQ I  D  LVFTV EFR   +++E+++  
Sbjct: 946  QDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFRELPNIEERIMNS 1005

Query: 211  --PYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
              P     A   +   PP+      E  K DIVFL+DGS      +F  +  F+++++  
Sbjct: 1006 FGPSAATPAPPGVDTPPPSRP----EKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDT 1061

Query: 269  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
            +    D IQV + QY      EF+     TKR++I A+ K+    G    T   L+ +R 
Sbjct: 1062 VYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRV 1121

Query: 329  NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 388
            N F   AG R  + +P++  +ITGGKS+++    +  L +  +  FA+G +  D  E+ +
Sbjct: 1122 NHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGK 1181

Query: 389  IAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFLL 438
            IA +S+       FR   +Q +       L TL            T    +   D+I   
Sbjct: 1182 IASNSA-----TAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGF 1236

Query: 439  DGSAN----VGKTNFPYVRDFVMNLVNSLDI------GNDNIRVGLVQFSDT-PVTEFSL 487
            DGS +    V +  F    D ++N ++ +         +  +RV +V  + + PV  F  
Sbjct: 1237 DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEAFDF 1296

Query: 488  NTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
            + YQ   ++L   R ++ Q    L   +    VY N F ++    ++
Sbjct: 1297 DEYQ--PEMLEKFRNMRSQHPYVLTEDTL--KVYLNKFRQSSPDSVK 1339



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 95/406 (23%), Positives = 176/406 (43%), Gaps = 57/406 (14%)

Query: 622  PLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVK----PEGTRIAVAQYSD 676
            PL  P    ++ F  D S  +    F  +RD +  I+++L +     P G R+AV  Y++
Sbjct: 1786 PLECPVFPTELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNN 1845

Query: 677  DVKVESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
            +V  E RF + + K  +L+ +K +++  T K  +L  A+ +  R  F      R+ +G L
Sbjct: 1846 EVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTF-----KRVRNGFL 1900

Query: 736  QFLVLL----VAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
               V +       R+S ++      L  +G+ P +F  +  D   +  + ++   +  A 
Sbjct: 1901 MRKVAVFFSNTPTRASPQLREAVLKLSDAGITP-LFLTRQEDRQLINALQINNTAVGHAL 1959

Query: 792  SLPKIGDLHPQIVNLL---------------------KSVHNGAPAPVSGEKDVVFLLDG 830
             LP   DL   + N+L                      S  +   A    + D+ F+LD 
Sbjct: 1960 VLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDS 2019

Query: 831  SEGVR-SGFPLLKEFVQRVVESLDVGQDR------VRVAVVQYSDR----------TRPE 873
            +E      F  +K+++  +V  LD+  D        RVAVVQ++             + E
Sbjct: 2020 AETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVE 2079

Query: 874  FYLNSYMNKQDVVNAV-RQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 932
            F L  Y +K+ +V+ + R +T L G T   G+A+E+ + N+  S+   R  + V  +L  
Sbjct: 2080 FSLTDYGSKEKLVDFLSRGMTQLQG-TRALGSAIEYTIENVFESAPNPRDLKIVVLMLTG 2138

Query: 933  LTADRSGDDVRNPSVVVKRGGAVPIGIGIG-NADITEMQTISFIPD 977
               ++  ++ +   +  K  G   + +GIG   +I E+ T +  P+
Sbjct: 2139 EVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPN 2184



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 52/370 (14%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQI----RVGVVQFSDEPRTMFSLD 91
            ++ F +D S       F  + D +++++  L I         RV VV +++E  T     
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 92   TYSTKAQVLGAVKALGFA-GGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAG 150
                K+ +L  +K L  A   +  ++  A+ FV  N F R     +   + +V V  S  
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFL---MRKVAVFFSNT 1911

Query: 151  PS--SDEIRYGVVALKQASVFSFGL----GAQAASRAELQHIATDDNLVFTVPEFRSFGD 204
            P+  S ++R  V+ L  A +    L      Q  +  ++ + A    LV  +P  R   D
Sbjct: 1912 PTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV--LPAGRDLTD 1969

Query: 205  LQEKLLPYIV-----------GVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLA 253
              E +L   V           G        +        +++   D+ F++D +    L 
Sbjct: 1970 FLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDI---DMAFILDSAETTTLF 2026

Query: 254  NFNAIRDFIAKVIQRLEIGQD------LIQVAVAQYADT----------VRPEFYFNTHP 297
             FN ++ +IA ++++L++  D        +VAV Q+A +          V+ EF    + 
Sbjct: 2027 QFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYG 2086

Query: 298  TKREVITAV-RKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            +K +++  + R M  L G+    GSA+++   N+F S+   R      K++VL+  G+  
Sbjct: 2087 SKEKLVDFLSRGMTQLQGTRA-LGSAIEYTIENVFESAPNPRDL----KIVVLMLTGEVP 2141

Query: 357  DEISQPAQEL 366
            ++  + AQ +
Sbjct: 2142 EQQLEEAQRV 2151



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/349 (22%), Positives = 145/349 (41%), Gaps = 42/349 (12%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN----IRVGLVQFSDTPVTEFSLN 488
            ++ F LD S  V +  F  +RD V+++VN L I   N     RV +V +++   TE    
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 489  TYQTKSDILGHLRQLQLQGGSGLNT-GSALSYVYANHFTEAGGSRIREHVPQLLLLLTAG 547
              + KS +L  ++ LQ+   S   +  +A+S+V  N F       +   V  +    T  
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKV-AVFFSNTPT 1913

Query: 548  QSEDSYLQAANALTRAGI----LTFCVGASQANKAELEQIAFNPSLV---------YLMD 594
            ++     +A   L+ AGI    LT        N  ++   A   +LV         +L +
Sbjct: 1914 RASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLEN 1973

Query: 595  DFSSLPALPQQLIQPLTTYVS--GGVEEVPLAQPESKRDILFLFDGS-ANLVGQFPVVRD 651
              +    L    I P   + S      +   A  +   D+ F+ D +    + QF  ++ 
Sbjct: 1974 VLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKK 2033

Query: 652  FLYKIIDELNVKPEG------TRIAVAQYSDD----------VKVESRFDEHQSKPEILN 695
            ++  ++ +L++ P+        R+AV Q++            VKVE    ++ SK ++++
Sbjct: 2034 YIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD 2093

Query: 696  LVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAG 744
             + R   +      LG A++Y    +F  +   R     L+ +VL++ G
Sbjct: 2094 FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPR----DLKIVVLMLTG 2138



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 93/421 (22%), Positives = 158/421 (37%), Gaps = 70/421 (16%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 294
            ++ F +D S  +    F  +RD +  ++  L I +       +VAV  Y + V  E  F 
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 295  THPTKREVITAVRKMK-PLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLI--- 350
                K  ++  ++ ++  L        +A+ FV  N F      R   G     V +   
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK-----RVRNGFLMRKVAVFFS 1909

Query: 351  -TGGKSLDEISQPAQELKRSSIMAFAIGNKGADQA----ELEEIAFDSSLVFIPAEFRAA 405
             T  ++  ++ +   +L  + I    +  +   Q     ++   A   +LV +PA     
Sbjct: 1910 NTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALV-LPA---GR 1965

Query: 406  PLQGMLPGLLAPLRTL------------SGTPEVHSNKR-------DIIFLLDGSANVGK 446
             L   L  +L     L            S  P     +        D+ F+LD +     
Sbjct: 1966 DLTDFLENVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTL 2025

Query: 447  TNFPYVRDFVMNLVNSLDIGNDN------IRVGLVQFSDT---------PV-TEFSLNTY 490
              F  ++ ++  LV  LD+  D        RV +VQ + +         PV  EFSL  Y
Sbjct: 2026 FQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDY 2085

Query: 491  QTKSDILGHLRQ--LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
             +K  ++  L +   QLQG   L  GSA+ Y   N F  A   R    +  ++L+LT   
Sbjct: 2086 GSKEKLVDFLSRGMTQLQGTRAL--GSAIEYTIENVFESAPNPR---DLKIVVLMLTGEV 2140

Query: 549  SEDSYLQAANALTRA---GILTFCVG-ASQANKAELEQIAFNPSLVY--LMDDFSSLPAL 602
             E    +A   + +A   G     +G   + N  E+   A  P+ V+  L+D  + L   
Sbjct: 2141 PEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDKSTELNEE 2200

Query: 603  P 603
            P
Sbjct: 2201 P 2201



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 29/150 (19%), Positives = 69/150 (46%), Gaps = 7/150 (4%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 1081
            ++ F +D S+    + F  +R ++  +V+ L +         RVAV+ ++++   E    
Sbjct: 1795 ELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFA 1854

Query: 1082 AHSSKDEVQNAVQRLRPK-GGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
                K  + + ++ L+     +Q ++  A+ +V+RN FKR     +   V  F     + 
Sbjct: 1855 DSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPT- 1913

Query: 1141 KSDDEVDDPAVELKQFGVAPFTIARNADQE 1170
            ++  ++ +  ++L   G+ P  + R  D++
Sbjct: 1914 RASPQLREAVLKLSDAGITPLFLTRQEDRQ 1943


>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
          Length = 2263

 Score =  436 bits (1122), Expect = e-122
 Identities = 326/1202 (27%), Positives = 591/1202 (49%), Gaps = 60/1202 (4%)

Query: 28   QQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTM 87
            Q +  + AD++FL+D S+  GS +F  +  F+  ++  LPI   + RV + Q+SD+  + 
Sbjct: 19   QDSGPEYADVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSE 78

Query: 88   FSLDTYSTKAQVLGAV-KALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVL 146
            F L T+  ++ +L  + K  GF GG L  IG AL      +F+     R ++  P +LV+
Sbjct: 79   FHLSTFKGRSPMLNHLRKNFGFIGGSL-QIGKALQEAHRTYFSAPANGRDKKQFPPILVV 137

Query: 147  ISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQ 206
            +++  S D +     AL++  V    +G Q AS   L+ +AT     F +   R      
Sbjct: 138  LASSESEDNVEEASKALRKDGVKIISVGVQKASEENLKAMAT-SQFHFNLRTVRDLSMFS 196

Query: 207  EKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266
            + +   I  V +          V      +  D+VFL+D S      NF+ ++ F+ + +
Sbjct: 197  QNMTHIIKDVIKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESV 256

Query: 267  QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
              L+I ++ ++V +  Y++  +     +    K EV+  ++ + P  G A YTG+A+  +
Sbjct: 257  SALDIKENCMRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKA-YTGAAIKKL 315

Query: 327  RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
            R  +F++  G R  +G+P++ VL+T   S D +++ A  L+R  +  F +G +GA   +L
Sbjct: 316  RKEVFSARNGSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQL 375

Query: 387  EEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLR-----TLSGTPE---------VHSNKR 432
            E+IA   +  ++      A L       L  LR     T+S   E         V + + 
Sbjct: 376  EKIASHPAEQYVSKLKTFADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGCVDTEEA 435

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
            DI  L+DGS +   T+F  ++ F+  +V   +I    +RVG VQ++D+   EF +N Y  
Sbjct: 436  DIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSN 495

Query: 493  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
            K D+   +  ++  GG+  NTG+AL++  +    +    +    VP  L++LT G S+DS
Sbjct: 496  KQDLGKAIENIRQMGGN-TNTGAALNFTLS--LLQKAKKQRGNKVPCHLVVLTNGMSKDS 552

Query: 553  YLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTT 612
             L+ AN L    I  + +G  +AN+ +L +IA     VY + DF +L  +  Q++Q + T
Sbjct: 553  ILEPANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEICT 612

Query: 613  YVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAV 671
                  EE   A  E K DI+FL D S ++  + F  ++ F+  ++ +  + P+  +I V
Sbjct: 613  ------EE---ACKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGV 663

Query: 672  AQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIE 731
             Q+SD  K E + +   S+ +I N + +M    G+    G AL +  +Y F  + G+R  
Sbjct: 664  VQFSDINKEEFQLNRFMSQSDISNAIDQM-AHIGQTTLTGSALSFVSQY-FSPTKGAR-- 719

Query: 732  DGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAE 791
              + +FL+L+  G + D V  PA  L+Q GV+ +      ++  +LE+I   P  +   E
Sbjct: 720  PNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVE 779

Query: 792  SLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVE 850
            +   +  +   +V  + S             DVVF++D S  +    + ++K+F+  +V+
Sbjct: 780  NFDILQRIEDDLVFGICSPREECKR--IEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVK 837

Query: 851  SLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVL 910
              DVG+++VR   ++Y+D     FYL+ +  K +V++ ++    +GG T  T  AL F  
Sbjct: 838  KADVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGST-YTAEALGF-S 895

Query: 911  RNILVSSAGSRITEGVPQLLIVLTADRS--GDDVRNPSVVVKRGGAVPIGIGIGNADITE 968
             ++   + GSR+ +GVPQ+LIV+T   S   D +   +  ++  G + + +GI  A+  E
Sbjct: 896  DHMFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVE 955

Query: 969  MQTISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDV 1028
            +  ++   D    + TF  L  +   ++  V   ++ +                  K D+
Sbjct: 956  LLAMAGSSDKYFFVETFGGLKGIFSDVTASVCNSSKVDCEI--------------DKVDL 1001

Query: 1029 VFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKD 1087
            VFL+DGS S  P +F+ ++  +  +V   DV  +  R+   QFSD    EF L     + 
Sbjct: 1002 VFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEK 1061

Query: 1088 EVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVD 1147
            E+   ++ ++   G   ++G AL  V  + F+  +GSRI  G PQ L++++ G+S DEV 
Sbjct: 1062 EISFQIENIKQIFG-NTHIGAALREV-EHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVA 1119

Query: 1148 DPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLT 1206
              A  L+  G+  +++   + D ++L++I+ + E   +V  F EL  + ++++  I T  
Sbjct: 1120 QAAEALRHRGIDIYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNICTTA 1179

Query: 1207 SE 1208
             E
Sbjct: 1180 GE 1181



 Score =  255 bits (652), Expect = 2e-67
 Identities = 170/588 (28%), Positives = 313/588 (53%), Gaps = 25/588 (4%)

Query: 27   QQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRT 86
            ++   +  ADI+FL+D S + G  NF+ +  F+ NL+ K  IG  ++++GVVQFSD  + 
Sbjct: 613  EEACKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKE 672

Query: 87   MFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVL 146
             F L+ + +++ +  A+  +    G+    G AL F V  +F+   G+R    + + L+L
Sbjct: 673  EFQLNRFMSQSDISNAIDQMAHI-GQTTLTGSALSF-VSQYFSPTKGAR--PNIRKFLIL 728

Query: 147  ISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQ 206
            I+ G + D ++   V L+Q  V  + +G   ++  +L+ I+    +VF V  F     ++
Sbjct: 729  ITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIE 788

Query: 207  EKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266
            + L   + G+         P    + IEV   D+VF++D S ++    +N ++DF+  ++
Sbjct: 789  DDL---VFGICS-------PREECKRIEV--LDVVFVIDSSGSIDYDEYNIMKDFMIGLV 836

Query: 267  QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
            ++ ++G++ ++    +YAD     FY +   TK EVI+ ++  + + GS  YT  AL F 
Sbjct: 837  KKADVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGST-YTAEALGF- 894

Query: 327  RNNLFTSSAGYRAAEGIPKLLVLITGGKS--LDEISQPAQELKRSSIMAFAIGNKGADQA 384
             +++FT + G R  +G+P++L++IT G+S   D+++  A+ L+   I+  A+G  GA+  
Sbjct: 895  SDHMFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPV 954

Query: 385  ELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANV 444
            EL  +A  S   F    F    L+G+   + A +   S   +   +K D++FL+DGS ++
Sbjct: 955  ELLAMAGSSDKYFFVETF--GGLKGIFSDVTASVCN-SSKVDCEIDKVDLVFLMDGSTSI 1011

Query: 445  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 504
               +F  +++F+ ++V   D+  + +R+G  QFSDT   EF L T+  + +I   +  ++
Sbjct: 1012 QPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIK 1071

Query: 505  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 564
               G+  + G+AL  V  ++F    GSRI    PQ+LL+LT GQS+D   QAA AL   G
Sbjct: 1072 QIFGN-THIGAALREV-EHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRG 1129

Query: 565  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTT 612
            I  + VG    +  +L QI         + +F  L  + +++++ + T
Sbjct: 1130 IDIYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNICT 1177



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 70/365 (19%), Positives = 148/365 (40%), Gaps = 41/365 (11%)

Query: 626  PESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVK----PEGTRIAVAQYSDDVKV 680
            P    +++F  D S ++  Q F  +++ +  ++ ++ V+    P G  IA+  Y+   + 
Sbjct: 1752 PVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARH 1811

Query: 681  ESRFDEHQSKPEILNLVKRMKIKTGKA-LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLV 739
              RF +   K ++L  ++ +  +   A   +G A+ +  R +F ++        +  F  
Sbjct: 1812 LVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTLPGAHTRKIATF-- 1869

Query: 740  LLVAGRSSD--RVDGPASNLKQSGVVPFIFQAKNA---------DPAELEQIVLSPA--- 785
               +G+S+D   +   A       ++P +    N          D     Q+++ P+   
Sbjct: 1870 -FSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGAD 1928

Query: 786  FILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSG-FPLLKEF 844
            +I A E L +    +  +     S     P PV    D  FLLD S  + S  F  ++ F
Sbjct: 1929 YIPALERLQRCTFCY-DVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIRAF 1987

Query: 845  VQRVVESLDVGQDRV------RVAVVQYS----------DRTRPEFYLNSYMNKQDVVNA 888
            +  +++  ++  +        RVA++ ++             R EF L +Y +K+ +   
Sbjct: 1988 LGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRH 2047

Query: 889  VRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVV 948
            V +           G AL++ L N+ +S+   R  + +  +    T+   G+ ++  S+ 
Sbjct: 2048 VHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNKVIFVISAGETSHLDGEILKKESLR 2107

Query: 949  VKRGG 953
             K  G
Sbjct: 2108 AKCQG 2112



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 84/412 (20%), Positives = 160/412 (38%), Gaps = 72/412 (17%)

Query: 423  GTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVG--------- 473
            G PE   +  +++F LD S +V +  F  +++ +  LV  + +  ++  VG         
Sbjct: 1747 GKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYN 1806

Query: 474  -----LVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGS-GLNTGSALSYVYANHFTE 527
                 LV+FSD             KS +L  +  +  +  S     G A+ ++  N F  
Sbjct: 1807 SHARHLVRFSDA----------YKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKR 1856

Query: 528  AGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQ-IAFN 586
               +    H  ++    ++GQS D++     A+    +    V  + +N   + +  A +
Sbjct: 1857 ---TLPGAHTRKIATFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAID 1913

Query: 587  PS----LVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP---ESKRDILFLFDGS 639
             +    ++ +      +PAL +         V         A+P   +S  D  FL D S
Sbjct: 1914 DTGTFQVIVVPSGADYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDAS 1973

Query: 640  ANL-VGQFPVVRDFLYKIIDELNVKPE------GTRIAVAQYS----------DDVKVES 682
             N+   +F  +R FL  ++D   + PE      G R+A+  ++            V+ E 
Sbjct: 1974 RNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEF 2033

Query: 683  RFDEHQSKPEILNLVKRMKIKTGKALN----LGYALDYAQRYIFVKSAGSRIEDGVLQFL 738
                ++SK     L+KR   ++ K LN    +G+AL +    +F+ +   R        +
Sbjct: 2034 NLTTYRSK----RLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNK-----V 2084

Query: 739  VLLVAGRSSDRVDG-----PASNLKQSGVVPFIFQAKNA-DPAELEQIVLSP 784
            + +++   +  +DG      +   K  G   F+F      D  ELE +   P
Sbjct: 2085 IFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDDKELEDLASHP 2136



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 85/396 (21%), Positives = 153/396 (38%), Gaps = 55/396 (13%)

Query: 235  VNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQV----AVAQYADTVRPE 290
            V+  ++VF +D S  +    F  +++ +A +++ +++ ++   V    A+  Y    R  
Sbjct: 1753 VHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARHL 1812

Query: 291  FYFNTHPTKREVITAVRKMKPLDGSALYT-GSALDFVRNNLFTSSAGYRAAEGIPKLLVL 349
              F+    K +++  +  +     SA    G A+ F+  N+F  +          K+   
Sbjct: 1813 VRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTL---PGAHTRKIATF 1869

Query: 350  ITGGKSLD--EISQPAQELKRSSIM--------------AFAIGNKGADQAELEEIAFDS 393
             + G+S D   I+  A E     I+              AFAI + G  Q     I   S
Sbjct: 1870 FSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQV----IVVPS 1925

Query: 394  SLVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVR 453
               +IPA  R                     P    +  D  FLLD S N+G   F  +R
Sbjct: 1926 GADYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIR 1985

Query: 454  DFVMNLVNSLDIGND------NIRVGLVQFS---------DTPV-TEFSLNTYQTKSDIL 497
             F+  L++  +I  +        RV L+  +          +PV  EF+L TY++K  + 
Sbjct: 1986 AFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMK 2045

Query: 498  GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE--DSYLQ 555
             H+ +   Q       G AL +   N F      R      +++ +++AG++   D  + 
Sbjct: 2046 RHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRN----KVIFVISAGETSHLDGEIL 2101

Query: 556  AANALTRA----GILTFCVGASQANKAELEQIAFNP 587
               +L        +  F +G    +K ELE +A +P
Sbjct: 2102 KKESLRAKCQGYALFVFSLGPIWDDK-ELEDLASHP 2136



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 38/162 (23%), Positives = 72/162 (44%), Gaps = 22/162 (13%)

Query: 1019 SPGVGGK-------RDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDT----TRVA 1066
            SPG  GK        ++VF +D S+     EF+ ++ ++  LV  + V  ++      +A
Sbjct: 1742 SPGRHGKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIA 1801

Query: 1067 VIQFSDDPKVEFLLNAHSSKDEVQNAVQRL---RPKGGRQINVGNALEYVSRNIFKRPLG 1123
            ++ ++   +     +    K ++   ++ +   R    R+I  G A+ ++SRN+FKR L 
Sbjct: 1802 ILSYNSHARHLVRFSDAYKKSQLLREIETIPYERSSASREI--GRAMRFISRNVFKRTLP 1859

Query: 1124 SRIEEGVPQFLVLISSGKSDD--EVDDPAVELKQFGVAPFTI 1163
                  +  F    SSG+S D   +   A+E     + P  I
Sbjct: 1860 GAHTRKIATF---FSSGQSADAHSITTAAMEFGALEIIPVVI 1898



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 45/142 (31%), Positives = 58/142 (40%), Gaps = 28/142 (19%)

Query: 32   QDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPI----GTQQIRVGVVQFSDEP--- 84
            Q   D  FL+D S N GS  F  I  FL  LL+   I     T      V   S  P   
Sbjct: 1961 QSYMDAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDF 2020

Query: 85   ---------RTMFSLDTYST----KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRA 131
                     R  F+L TY +    K  V  +VK L    G+ A IG AL + ++N F   
Sbjct: 2021 LPNTQKSPVRAEFNLTTYRSKRLMKRHVHESVKQL---NGD-AFIGHALQWTLDNVFLST 2076

Query: 132  GGSRVEEGVPQVLVLISAGPSS 153
               R      +V+ +ISAG +S
Sbjct: 2077 PNLRRN----KVIFVISAGETS 2094


>gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]
          Length = 2526

 Score =  393 bits (1009), Expect = e-109
 Identities = 318/1189 (26%), Positives = 571/1189 (48%), Gaps = 68/1189 (5%)

Query: 35   ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
            AD++FL+D S++ G  +F  +  F+  ++  LPI   + RV + Q+SDE  + F L T+ 
Sbjct: 29   ADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFK 88

Query: 95   TKAQVLGAVKA-LGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
             ++ +L  +K    F GG L  IG AL      +F+     R  +  P +LV++++  S 
Sbjct: 89   GRSPMLNHLKKNFQFIGGSL-QIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESE 147

Query: 154  DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPYI 213
            DE+     AL++  V    +G Q AS   L+ +AT  +  F +   R      + +   I
Sbjct: 148  DEVEEASKALQKDGVKIISVGVQKASEENLKAMAT-SHFHFNLRTIRDLSTFSQNMTQII 206

Query: 214  VGVAQ-RHIVLKPPTIVTQVIEVNK---RDIVFLVDGSSALGLANFNAIRDFIAKVIQRL 269
              V + +   +     V   I   K    D+VFLVD S   G  N   ++ F+  +   +
Sbjct: 207  KDVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTG-GNLRHLQTFLENITSSM 265

Query: 270  EIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNN 329
            ++ ++ +++ +  Y+++ +   +  +  T+ E    ++ +    G +  TG+A+D +R +
Sbjct: 266  DVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAAIDQMRRD 324

Query: 330  LFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEI 389
             F+ S G R A+G+P++ VL+T   S DE+   A  L+   +  FA+  +GA+  +LEEI
Sbjct: 325  GFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEI 384

Query: 390  AFDSSLVFIPAEFRAAPLQGMLPGLLAPL--------------RTLSGTPEVHSNKRDII 435
                    I      A L+      L  L              R L  T  V + + DI 
Sbjct: 385  VSYPPEQTISTLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADIH 444

Query: 436  FLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSD 495
            FL+DGS+++ +  F  ++ F++ +     IG D +RVG+VQ+SD    EF +  Y    D
Sbjct: 445  FLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDID 504

Query: 496  ILGHLRQL-QLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYL 554
            +   +  + QL GG+   TG AL Y+      + G       VP  L++LT G S D  +
Sbjct: 505  LRKAIFNIKQLTGGT--YTGKALDYIL--QIIKNGMKDRMSKVPCYLIVLTDGMSTDRVV 560

Query: 555  QAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYV 614
            + A  L    I    VG   ANK EL++IA     V    +F +L ++  ++++ +    
Sbjct: 561  EPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVREIC--A 618

Query: 615  SGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQ 673
              G E++       K DI+FL D S ++  + F  ++ F+  ++ ++ +  + T+I V Q
Sbjct: 619  EKGCEDM-------KADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGADKTQIGVVQ 671

Query: 674  YSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDG 733
            +SD  K E + + + ++ EI + + RM +     L  G AL++  +Y F  S G+R+  G
Sbjct: 672  FSDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTLT-GKALNFVGQY-FTHSKGARL--G 727

Query: 734  VLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESL 793
              +FL+L+  G + D V  PA  L+   V  F     NA+ ++LE+I    + +   E+ 
Sbjct: 728  AKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSSLVFHVENF 787

Query: 794  PKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGF-PLLKEFVQRVVESL 852
              +  L  +++  + ++H+     +    DVVF+LD S  ++  +   +      +V+  
Sbjct: 788  DHLKALERKLIFRVCALHDCKRITL---LDVVFVLDHSGSIKKQYQDHMINLTIHLVKKA 844

Query: 853  DVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRN 912
            DVG+DRV+   ++YSD+    FYLN+Y N+  ++  +R+    GG T  T  AL+     
Sbjct: 845  DVGRDRVQFGALKYSDQPNILFYLNTYSNRSAIIENLRKRRDTGGNT-YTAKALKHA-NA 902

Query: 913  ILVSSAGSRITEGVPQLLIVLTADRS--GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQ 970
            +     GSRI + V Q+LIV+T   S   D + + ++ ++  G     +G+G A+  E++
Sbjct: 903  LFTEEHGSRIKQNVKQMLIVITDGESHDHDQLNDTALELRNKGITIFAVGVGKANQKELE 962

Query: 971  TISFIPDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVF 1030
             ++   +  + +  F +L  V  ++ ER+      E+  LQ             + DV+F
Sbjct: 963  GMAGNKNNTIYVDNFDKLKDVFTLVQERMC-TEAPEVCHLQ-------------EADVIF 1008

Query: 1031 LIDGS-QSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEV 1089
            L DGS + +  +F  + T +  L+D  D+     ++ + QF  + +    L    +K + 
Sbjct: 1009 LCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFGSNYQSIIELKNSLTKTQW 1068

Query: 1090 QNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDP 1149
            +  +Q +   GG    +  AL+ VS N+F    G R   GVPQ LV+I+SG    +V D 
Sbjct: 1069 KTQIQNVSKSGGFP-RIDFALKKVS-NMFNLHAGGRRNAGVPQTLVVITSGDPRYDVADA 1126

Query: 1150 AVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQK 1197
               LK  G+    +   +  +E L+ I+ + E + +   F +L +++ K
Sbjct: 1127 VKTLKDLGICVLVLGIGDVYKEHLLPITGNSEKIITFQDFDKLKNVDVK 1175



 Score =  328 bits (842), Expect = 1e-89
 Identities = 251/805 (31%), Positives = 407/805 (50%), Gaps = 62/805 (7%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
            D++FL+D S ++G  +FP+V+ F+  ++NSL I  +  RV L Q+SD   +EF L+T++ 
Sbjct: 30   DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89

Query: 493  KSDILGHLRQ-LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED 551
            +S +L HL++  Q  GGS L  G AL   +  +F+     R R+  P +L++L + +SED
Sbjct: 90   RSPMLNHLKKNFQFIGGS-LQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESED 148

Query: 552  SYLQAANALTRAGILTFCVGASQANKAELEQIA-----FNPSLVYLMDDFSSLPALPQQL 606
               +A+ AL + G+    VG  +A++  L+ +A     FN   +  + D S+      Q+
Sbjct: 149  EVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFN---LRTIRDLSTFSQNMTQI 205

Query: 607  IQPLTTYVSGGVE-----EVPLA-QPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDEL 660
            I+ +T Y  G V+       P++ Q +S  D++FL D S    G    ++ FL  I   +
Sbjct: 206  IKDVTKYKEGAVDADMQVHFPISCQKDSLADLVFLVDESLGTGGNLRHLQTFLENITSSM 265

Query: 661  NVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRY 720
            +VK    R+ +  YS+  K  S      ++ E    +K + I+ GK+ N G A+D  +R 
Sbjct: 266  DVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAAIDQMRRD 324

Query: 721  IFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780
             F +S GSR   GV Q  VL+    S D V   A NL+   V  F    + A+  +LE+I
Sbjct: 325  GFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEI 384

Query: 781  VLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVS----------------GEKDV 824
            V  P       +L    DL       LK + N   + +S                 E D+
Sbjct: 385  VSYPP-EQTISTLKSYADLETYSTKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADI 443

Query: 825  VFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQ 883
             FL+DGS  ++   F  +K F+  V E   +G D+VRV VVQYSD T  EFY+  Y N  
Sbjct: 444  HFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDI 503

Query: 884  DVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVR 943
            D+  A+  +  L G T  TG AL+++L+ I+ +    R+++ VP  LIVLT   S D V 
Sbjct: 504  DLRKAIFNIKQLTGGT-YTGKALDYILQ-IIKNGMKDRMSK-VPCYLIVLTDGMSTDRVV 560

Query: 944  NPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ-QVISERVTQL 1002
             P+  ++        +GIG A+  E+Q I+   +       F  L +++ +V+ E   + 
Sbjct: 561  EPAKRLRAEQITVHAVGIGAANKIELQEIAGKEERVSFGQNFDALKSIKNEVVREICAEK 620

Query: 1003 TREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFD 1061
              E++                 K D++FL+D S S G E F+ ++  ++ L+  + +G D
Sbjct: 621  GCEDM-----------------KADIMFLVDSSWSIGNENFRKMKIFMKNLLTKIQIGAD 663

Query: 1062 TTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRP 1121
             T++ V+QFSD  K EF LN + ++ E+ +A+ R+       +  G AL +V +  F   
Sbjct: 664  KTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTL-TGKALNFVGQ-YFTHS 721

Query: 1122 LGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE 1180
             G+R+  G  +FL+LI+ G + D+V DPA  L+   V  F++   NA++ +L +IS    
Sbjct: 722  KGARL--GAKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLEEISGDSS 779

Query: 1181 YVFSVSTFRELPSLEQKLLTPITTL 1205
             VF V  F  L +LE+KL+  +  L
Sbjct: 780  LVFHVENFDHLKALERKLIFRVCAL 804



 Score =  157 bits (396), Expect = 8e-38
 Identities = 111/406 (27%), Positives = 202/406 (49%), Gaps = 14/406 (3%)

Query: 814  APAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRP 872
            +P P     DVVFL+D S+ +    FP +K F+ +++ SL +  ++ RVA+ QYSD    
Sbjct: 21   SPGPGPVYADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHS 80

Query: 873  EFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIV 932
            EF+L+++  +  ++N +++     G +   G AL+   R    +    R  +  P +L+V
Sbjct: 81   EFHLSTFKGRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVV 140

Query: 933  LTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQ 992
            L +  S D+V   S  +++ G   I +G+  A    ++ ++    F   + T R L T  
Sbjct: 141  LASAESEDEVEEASKALQKDGVKIISVGVQKASEENLKAMA-TSHFHFNLRTIRDLSTFS 199

Query: 993  QVISERVTQLTREELSRLQPVLQ---PLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLI 1049
            Q +++ +  +T+ +   +   +Q   P+ S       D+VFL+D S   G   ++++T +
Sbjct: 200  QNMTQIIKDVTKYKEGAVDADMQVHFPI-SCQKDSLADLVFLVDESLGTGGNLRHLQTFL 258

Query: 1050 ERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNA 1109
            E +   +DV  +  R+ ++ +S+  K    L + +++ E Q  ++ L  + G+  N G A
Sbjct: 259  ENITSSMDVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKS-NTGAA 317

Query: 1110 LEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI----AR 1165
            ++ + R+ F    GSR  +GVPQ  VL++   SDDEV D A+ L+   V  F +    A 
Sbjct: 318  IDQMRRDGFSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGAN 377

Query: 1166 NADQEELVKISLSPEYVFS-VSTFRELPSLEQKLLTPITTLTSEQI 1210
            N   EE+V  S  PE   S + ++ +L +   K L  +      QI
Sbjct: 378  NTQLEEIV--SYPPEQTISTLKSYADLETYSTKFLKKLQNEIWSQI 421



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 78/381 (20%), Positives = 161/381 (42%), Gaps = 39/381 (10%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLI----QVAVAQYADTVRPEFYFN 294
            ++VF +D S  +   +FN  RD I  ++  L I ++      +VA+  Y         ++
Sbjct: 1758 ELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSYLIRWS 1817

Query: 295  THPTKREVITAVRKMKPLDGSALY-TGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGG 353
             +  K++++  + ++K  D +     G+A+ FV  N+F  +    A   + ++ V  + G
Sbjct: 1818 DYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTY---AGANVRRVAVFFSNG 1874

Query: 354  KSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVF----IPAEFRAAPLQG 409
            ++    S     ++ S++          ++  LE   FD++  F    +P       L+ 
Sbjct: 1875 QTASRSSIITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNGENQTLER 1934

Query: 410  MLPGLLA-----PLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464
            +    L      P   +        +  D++FL+D S N+ K  F  V+  V +++++ +
Sbjct: 1935 LRRCALCYDKCFPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFN 1994

Query: 465  IGNDNI------RVGLVQFS---------DTPVTEFSLNTYQTKSDILGHLRQLQLQGGS 509
            I +D +      R+ L+ +S          T  TEF   TY  +  +  H++    Q   
Sbjct: 1995 IASDPLISDSGDRIALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNG 2054

Query: 510  GLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRA---GIL 566
                G AL +   N F E     +R+H  +++ +++AG++ +          RA   G +
Sbjct: 2055 EATIGRALLWTTENLFPET--PYLRKH--KVIFVVSAGENYERKEFVKMMALRAKCQGYV 2110

Query: 567  TFCVGASQANKAELEQIAFNP 587
             F +      K ++E++A  P
Sbjct: 2111 IFVISLGSTRKDDMEELASYP 2131



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)

Query: 626  PESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVK----PEGTRIAVAQYSDDVKV 680
            P    +++F  D S ++  + F   RD +  I+++LN++    P G R+A+  Y+     
Sbjct: 1753 PAYPTELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSY 1812

Query: 681  ESRFDEHQSKPEILNLVKRMKIK-TGKALNLGYALDYAQRYIFVKS-AGSRIEDGVLQFL 738
              R+ ++  K ++L  + ++K + T +  ++G A+ +  R +F ++ AG+ +    + F 
Sbjct: 1813 LIRWSDYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAGANVRRVAVFFS 1872

Query: 739  VLLVAGRSSDRVDGPASNLKQSGVVPFIF--------QAKNADPAELEQIVLSP--AFIL 788
                A RSS  +           + P +F        +A   D     Q++  P      
Sbjct: 1873 NGQTASRSS--IITATMEFSALDISPTVFAFDERVFLEAFGFDNTGTFQVIPVPPNGENQ 1930

Query: 789  AAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQR 847
              E L +    + +      +    A  P     DVVFL+D S  + +  F  +K  V  
Sbjct: 1931 TLERLRRCALCYDKC--FPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSS 1988

Query: 848  VVESLDVGQDRV------RVAVVQYS 867
            V+++ ++  D +      R+A++ YS
Sbjct: 1989 VIDNFNIASDPLISDSGDRIALLSYS 2014



 Score = 37.7 bits (86), Expect = 0.068
 Identities = 32/146 (21%), Positives = 68/146 (46%), Gaps = 11/146 (7%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDT----TRVAVIQFSDDPKVEFLLN 1081
            ++VF +D S     E F   R +I  +V+ L++  +      RVA++ ++         +
Sbjct: 1758 ELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCPVGARVAMVSYNSGTSYLIRWS 1817

Query: 1082 AHSSKDEVQNAVQRLRPKGGRQI-NVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSG 1140
             ++ K ++   + +++ +   +  +VGNA+ +V+RN+FKR         V +  V  S+G
Sbjct: 1818 DYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFKRTYAG---ANVRRVAVFFSNG 1874

Query: 1141 K--SDDEVDDPAVELKQFGVAPFTIA 1164
            +  S   +    +E     ++P   A
Sbjct: 1875 QTASRSSIITATMEFSALDISPTVFA 1900



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 40/196 (20%), Positives = 77/196 (39%), Gaps = 26/196 (13%)

Query: 20   FPTTHAQQQQAAQDS-ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQI----- 73
            FP    ++    +DS  D++FLID S N     F  +   + ++++   I +  +     
Sbjct: 1946 FPNACIREAFLPEDSYMDVVFLIDNSRNIAKDEFKAVKALVSSVIDNFNIASDPLISDSG 2005

Query: 74   -RVGVVQFS---------DEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFV 123
             R+ ++ +S            +T F   TY  +  +   ++         A IG AL + 
Sbjct: 2006 DRIALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWT 2065

Query: 124  VENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQAS-----VFSFGLGA-QA 177
             EN F      R      +V+ ++SAG + +   +  +   +A      +F   LG+ + 
Sbjct: 2066 TENLFPETPYLRKH----KVIFVVSAGENYERKEFVKMMALRAKCQGYVIFVISLGSTRK 2121

Query: 178  ASRAELQHIATDDNLV 193
                EL     D +L+
Sbjct: 2122 DDMEELASYPLDQHLI 2137


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score =  174 bits (440), Expect = 6e-43
 Identities = 153/607 (25%), Positives = 281/607 (46%), Gaps = 62/607 (10%)

Query: 36   DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
            D++FL+DGS+      F V+  F+V+++E+L I  + +RV VV++ D       L     
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 96   KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGP---S 152
             +++      + +AG ++A+    L + +   F++    R E     +L++ S  P   S
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKI--DRPEASRITLLLMASQEPQRMS 1394

Query: 153  SDEIRYGVVALKQASVFSF--GLGAQA-ASRAELQHIATDDNLVFTVPEFRSFGDLQEKL 209
             + +RY V  LK+  V     G+G  A   +  L      +N  F +         ++++
Sbjct: 1395 RNFVRY-VQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEI 1453

Query: 210  LPYIVGVAQRHIVLKPPTIVTQVIEVN-------------KR-----DIVFLVDGSSALG 251
            + Y+  +A       PPT+   + +V              KR     D+ F+++GS  +G
Sbjct: 1454 VSYLCDLAPE---APPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIG 1510

Query: 252  LANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKP 311
             A+FN  ++F+ +VIQR+++GQD I V V QY+  V  E+ F+   +K +++  VR+++ 
Sbjct: 1511 EADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRY 1570

Query: 312  LDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSI 371
              G+   TG AL ++ ++ F  S G R  E  P L+ ++TG  + DEI +   +++   +
Sbjct: 1571 QGGNRTNTGLALRYLSDHSFLVSQGDR--EQAPNLVYMVTGNPASDEIKRLPGDIQ---V 1625

Query: 372  MAFAIGNKGADQAELEEIAFDSSLVFI------PAEFRAAPLQGMLPGLLAPLRTLSGTP 425
            +   +G   A+  ELE I + ++ + I      P E     LQ    G    + TLS  P
Sbjct: 1626 VPIGVG-PNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTLSPAP 1684

Query: 426  EVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEF 485
            +  S   D+I LLDGS++   + F  ++ F    ++  +IG    +V ++Q+      + 
Sbjct: 1685 DC-SQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDV 1743

Query: 486  SLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLT 545
              N    K+ +L  +  +Q +GG     G AL +      +E  G+  R    + +++L 
Sbjct: 1744 PWNVVPEKAHLLSLVDVMQREGGPS-QIGDALGFAVRYLTSEMHGA--RPGASKAVVILV 1800

Query: 546  AGQSEDSYLQAANALTRAGILTFCVG----------------ASQANKAELEQIAFNPSL 589
               S DS   AA+A     +  F +G                A  +N  +L++I   P++
Sbjct: 1801 TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM 1860

Query: 590  VYLMDDF 596
            V L + F
Sbjct: 1861 VTLGNSF 1867



 Score =  171 bits (433), Expect = 4e-42
 Identities = 158/607 (26%), Positives = 273/607 (44%), Gaps = 59/607 (9%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
            D+VFL+DGSS L  A F  ++ F+  +++RL I Q  ++VAV +Y D             
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 299  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
              E+     ++K        T   L +    +F+      A+    ++ +L+   +    
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEAS----RITLLLMASQEPQR 1392

Query: 359  ISQP----AQELKRSSIMAFAIG-------------------NKG-----ADQAELEEIA 390
            +S+      Q LK+  ++   +G                   NK       D+ E +   
Sbjct: 1393 MSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDE 1452

Query: 391  FDSSLVFIPAEFRAAPLQGML------PGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANV 444
              S L  +  E     L   +      PGLL  + TL   P+ +S   D+ F+L+GS  +
Sbjct: 1453 IVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLG-VSTLG--PKRNSMVLDVAFVLEGSDKI 1509

Query: 445  GKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQ 504
            G+ +F   ++F+  ++  +D+G D+I V ++Q+S     E+  +  Q+K DIL  +R+++
Sbjct: 1510 GEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIR 1569

Query: 505  LQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAG 564
             QGG+  NTG AL Y+  + F  + G   RE  P L+ ++T   + D   +    +    
Sbjct: 1570 YQGGNRTNTGLALRYLSDHSFLVSQGD--REQAPNLVYMVTGNPASDEIKRLPGDIQ--- 1624

Query: 565  ILTFCVGASQANKAELEQIAFNPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLA 624
            ++   VG + AN  ELE+I + P+   L+ DF +LP     L+  L    SG   ++P  
Sbjct: 1625 VVPIGVGPN-ANVQELERIGW-PNAPILIQDFETLPREAPDLV--LQRCCSGEGLQIPTL 1680

Query: 625  QP----ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVK 679
             P        D++ L DGS++     F  ++ F    I + N+ P  T+++V QY     
Sbjct: 1681 SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT 1740

Query: 680  VESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLV 739
            ++  ++    K  +L+LV  M+ + G    +G AL +A RY+  +  G+R   G  + +V
Sbjct: 1741 IDVPWNVVPEKAHLLSLVDVMQ-REGGPSQIGDALGFAVRYLTSEMHGAR--PGASKAVV 1797

Query: 740  LLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDL 799
            +LV   S D VD  A   + + V  F     +   A   +I+  PA       L +I DL
Sbjct: 1798 ILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDL 1857

Query: 800  HPQIVNL 806
             P +V L
Sbjct: 1858 -PTMVTL 1863



 Score =  149 bits (377), Expect = 1e-35
 Identities = 152/600 (25%), Positives = 268/600 (44%), Gaps = 69/600 (11%)

Query: 607  IQPLTTYVSGGVEEVPLAQPESKR--DILFLFDGSANLV-GQFPVVRDFLYKIIDELNVK 663
            + P T YV   + E PL      R  D++FL DGS+ L   +F V++ F+  +++ L + 
Sbjct: 1252 VSPTTLYVED-ISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRIS 1310

Query: 664  PEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFV 723
             +  R+AV +Y D         + +   E+  +  ++K    +  +    L Y    IF 
Sbjct: 1311 QKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFS 1370

Query: 724  K---SAGSRIEDGVLQFLVLLVAGRSSDRVD----------------------GPASNLK 758
            K      SRI        +LL+A +   R+                       GP +NLK
Sbjct: 1371 KIDRPEASRIT-------LLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLK 1423

Query: 759  QSGVVP--------FIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVNL---- 806
            Q  ++         F+  + +    + ++IV S    LA E+ P    L P +  +    
Sbjct: 1424 QIRLIEKQAPENKAFVLSSVDELEQQRDEIV-SYLCDLAPEAPPPT--LPPDMAQVTVGP 1480

Query: 807  -LKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVV 864
             L  V    P   S   DV F+L+GS+ +  + F   KEF++ V++ +DVGQD + V V+
Sbjct: 1481 GLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVL 1540

Query: 865  QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 924
            QYS     E+  +   +K D++  VR++   GG   NTG AL ++  +  + S G R  E
Sbjct: 1541 QYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDR--E 1598

Query: 925  GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 984
              P L+ ++T + + D+++     ++    VPIG+G  NA++ E++ I + P+  + I  
Sbjct: 1599 QAPNLVYMVTGNPASDEIKRLPGDIQ---VVPIGVG-PNANVQELERIGW-PNAPILIQD 1653

Query: 985  FRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQS-AGPEFQ 1043
            F    T+ +   + V Q          P L   P+P      DV+ L+DGS S     F 
Sbjct: 1654 FE---TLPREAPDLVLQRCCSGEGLQIPTLS--PAPDCSQPLDVILLLDGSSSFPASYFD 1708

Query: 1044 YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 1103
             +++  +  +   ++G   T+V+V+Q+     ++   N    K  + + V  ++ +GG  
Sbjct: 1709 EMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPS 1768

Query: 1104 INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163
              +G+AL +  R +     G+R   G  + +V++ +  S D VD  A   +   V  F I
Sbjct: 1769 -QIGDALGFAVRYLTSEMHGAR--PGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPI 1825



 Score =  137 bits (346), Expect = 5e-32
 Identities = 155/601 (25%), Positives = 262/601 (43%), Gaps = 76/601 (12%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
            D++FLLDGS+ + +  F  ++ FV++++  L I    +RV +V++ D       L   + 
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 493  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED- 551
             S++     Q++  G    +T   L Y     F++      R    ++ LLL A Q    
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKID----RPEASRITLLLMASQEPQR 1392

Query: 552  ---SYLQAANALTRAGILTFCVGA---------------SQANKA-------ELEQIAFN 586
               ++++    L +  ++   VG                +  NKA       ELEQ   +
Sbjct: 1393 MSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQR-D 1451

Query: 587  PSLVYLMD--DFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANL-V 643
              + YL D    +  P LP  + Q        GV  +   +     D+ F+ +GS  +  
Sbjct: 1452 EIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGE 1511

Query: 644  GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIK 703
              F   ++F+ ++I  ++V  +   + V QYS  V VE  F E QSK +IL  V+ ++ +
Sbjct: 1512 ADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQ 1571

Query: 704  TGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVV 763
             G   N G AL Y   + F+ S G R +   L ++V      +SD +     +++   VV
Sbjct: 1572 GGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMV--TGNPASDEIKRLPGDIQ---VV 1626

Query: 764  PFIFQAKNADPAELEQIVL--SPAFILAAESLPKIGDLHPQIVNLLKSVHNG-------- 813
            P I    NA+  ELE+I    +P  I   E+LP+     P +V  L+   +G        
Sbjct: 1627 P-IGVGPNANVQELERIGWPNAPILIQDFETLPREA---PDLV--LQRCCSGEGLQIPTL 1680

Query: 814  APAP-VSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTR 871
            +PAP  S   DV+ LLDGS     S F  +K F +  +   ++G    +V+V+QY   T 
Sbjct: 1681 SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT 1740

Query: 872  PEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLI 931
             +   N    K  +++ V  +   GGP+   G AL F +R +     G+R   G  + ++
Sbjct: 1741 IDVPWNVVPEKAHLLSLVDVMQREGGPS-QIGDALGFAVRYLTSEMHGAR--PGASKAVV 1797

Query: 932  VLTADRSGDDVRNPSVVVK--RGGAVPIGIG--------------IGNADITEMQTISFI 975
            +L  D S D V   +   +  R    PIGIG               G++++ ++Q I  +
Sbjct: 1798 ILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDL 1857

Query: 976  P 976
            P
Sbjct: 1858 P 1858


>gi|21359974 vitrin [Homo sapiens]
          Length = 693

 Score =  155 bits (392), Expect = 2e-37
 Identities = 114/389 (29%), Positives = 198/389 (50%), Gaps = 22/389 (5%)

Query: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296
           K D+ FL+DGS+++G   F   +  +A V Q L+IG     + V QY D     F   TH
Sbjct: 306 KIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTH 365

Query: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
              R++ TA+ K+    G +   G A+ FV  N F+ + G R+  G P ++V++  G   
Sbjct: 366 TNSRDLKTAIEKITQRGGLS-NVGRAISFVTKNFFSKANGNRS--GAPNVVVVMVDGWPT 422

Query: 357 DEISQPAQELKRSSIMAFAIGNKGADQAELEEIA---FDSSLVFIPAEFRAAPLQGM--L 411
           D++ + ++  + S I  F I  +GA + E + +    F +  V     F +  +Q    L
Sbjct: 423 DKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGL 482

Query: 412 PGLLAPL-RTLSGTPEVHSNKR-----DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDI 465
              L PL + +  T  +  +K      DI F++DGS++VG  NF  V  FV NL    +I
Sbjct: 483 HKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEI 542

Query: 466 GNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHF 525
            + + R+G VQ++     EF  + Y +K DIL  ++++    G G +TG+A+++     F
Sbjct: 543 SDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLF 601

Query: 526 TEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAF 585
            ++     + +  +L++L+T G+S D     A A    G++T+ +G + A + ELE IA 
Sbjct: 602 KKS-----KPNKRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIAT 656

Query: 586 NPSL--VYLMDDFSSLPALPQQLIQPLTT 612
           +P+    + +D+F +L     ++IQ + T
Sbjct: 657 HPARDHSFFVDEFDNLHQYVPRIIQNICT 685



 Score =  154 bits (390), Expect = 4e-37
 Identities = 105/364 (28%), Positives = 181/364 (49%), Gaps = 25/364 (6%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D+ FLIDGS + G   F +    L ++ + L IG     +GVVQ+ D P T F+L T++ 
Sbjct: 308 DLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTN 367

Query: 96  KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
              +  A++ +   GG L+N+G A+ FV +N F++A G+R   G P V+V++  G  +D+
Sbjct: 368 SRDLKTAIEKITQRGG-LSNVGRAISFVTKNFFSKANGNR--SGAPNVVVVMVDGWPTDK 424

Query: 156 IRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLV---------FTVPEFRSFGDLQ 206
           +       +++ +  F +  + A+  E Q++  + N           F     +S+  L 
Sbjct: 425 VEEASRLARESGINIFFITIEGAAENEKQYVV-EPNFANKAVCRTNGFYSLHVQSWFGLH 483

Query: 207 EKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266
           + L P +  V     +    T +      N  DI F++DGSS++G  NF  +  F+  + 
Sbjct: 484 KTLQPLVKRVCDTDRLACSKTCL------NSADIGFVIDGSSSVGTGNFRTVLQFVTNLT 537

Query: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
           +  EI     ++   QY    R EF F+ + +K +++ A++++    G    TG+A++F 
Sbjct: 538 KEFEISDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSGGT-STGAAINFA 596

Query: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
              LF  S   +      KL++LIT G+S D++  PA       ++ +AIG   A Q EL
Sbjct: 597 LEQLFKKSKPNKR-----KLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEEL 651

Query: 387 EEIA 390
           E IA
Sbjct: 652 EVIA 655



 Score =  147 bits (370), Expect = 8e-35
 Identities = 106/363 (29%), Positives = 177/363 (48%), Gaps = 17/363 (4%)

Query: 431 KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 490
           K D+ FL+DGS ++GK  F   +  + ++  +LDIG     +G+VQ+ D P T F+L T+
Sbjct: 306 KIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTH 365

Query: 491 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 550
               D+   + ++  +GG   N G A+S+V  N F++A G+R     P +++++  G   
Sbjct: 366 TNSRDLKTAIEKITQRGGLS-NVGRAISFVTKNFFSKANGNR--SGAPNVVVVMVDGWPT 422

Query: 551 DSYLQAANALTRAGILTFCV---GASQANKAELEQIAFNPSLVYLMDDFSSLPALP---- 603
           D   +A+     +GI  F +   GA++  K  + +  F    V   + F SL        
Sbjct: 423 DKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGL 482

Query: 604 QQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNV 662
            + +QPL   V             +  DI F+ DGS+++  G F  V  F+  +  E  +
Sbjct: 483 HKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEI 542

Query: 663 KPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIF 722
               TRI   QY+ + ++E  FD++ SKP+ILN +KR+   +G   + G A+++A   +F
Sbjct: 543 SDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLF 601

Query: 723 VKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL 782
            KS  ++      + ++L+  GRS D V  PA      GV+ +      A   ELE I  
Sbjct: 602 KKSKPNK-----RKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIAT 656

Query: 783 SPA 785
            PA
Sbjct: 657 HPA 659



 Score =  122 bits (305), Expect = 3e-27
 Identities = 129/504 (25%), Positives = 220/504 (43%), Gaps = 48/504 (9%)

Query: 724  KSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAK-NADPAELEQIVL 782
            +S G R ++  L       + ++  R D        SG     FQ    AD +  E    
Sbjct: 217  QSVGHRSQEMDLWSTATYTSSQNRPRADPGIQRQDPSGAA---FQKPVGADVSLGEMDSW 273

Query: 783  SPAFILAAESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLL 841
             P  +L  E L    +L  Q    L+ V  G P   + + D+ FL+DGS  + +  F + 
Sbjct: 274  KPGSVLLDEGLVPKEELSTQS---LEPVSLGDP---NCKIDLSFLIDGSTSIGKRRFRIQ 327

Query: 842  KEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPN 901
            K+ +  V ++LD+G     + VVQY D     F L ++ N +D+  A+ ++T  GG   N
Sbjct: 328  KQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGG-LSN 386

Query: 902  TGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGI 961
             G A+ FV +N    + G+R   G P +++V+      D V   S + +  G     I I
Sbjct: 387  VGRAISFVTKNFFSKANGNR--SGAPNVVVVMVDGWPTDKVEEASRLARESGINIFFITI 444

Query: 962  GNADITEMQTISFIPDFA------------VAIPTFRQLGTVQQVISERVTQLTREELSR 1009
              A   E Q +   P+FA            + + ++  L    Q + +RV    R   S+
Sbjct: 445  EGAAENEKQYV-VEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQPLVKRVCDTDRLACSK 503

Query: 1010 LQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVI 1068
                             D+ F+IDGS S G   F+ V   +  L    ++    TR+  +
Sbjct: 504  T-----------CLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAV 552

Query: 1069 QFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE 1128
            Q++ + ++EF  + +SSK ++ NA++R+    G   + G A+ +    +FK+   ++   
Sbjct: 553  QYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSG-GTSTGAAINFALEQLFKKSKPNK--- 608

Query: 1129 GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSV 1185
               + ++LI+ G+S D+V  PA+     GV  + I    A QEEL  I+  P  ++ F V
Sbjct: 609  --RKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFV 666

Query: 1186 STFRELPSLEQKLLTPITTLTSEQ 1209
              F  L     +++  I T  + Q
Sbjct: 667  DEFDNLHQYVPRIIQNICTEFNSQ 690



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 53/156 (33%), Positives = 92/156 (58%), Gaps = 6/156 (3%)

Query: 33  DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 92
           +SADI F+IDGS++ G+ NF  +L F+ NL ++  I     R+G VQ++ E R  F  D 
Sbjct: 507 NSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAVQYTYEQRLEFGFDK 566

Query: 93  YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 152
           YS+K  +L A+K +G+  G   + G A++F +E  F ++  ++      ++++LI+ G S
Sbjct: 567 YSSKPDILNAIKRVGYWSGG-TSTGAAINFALEQLFKKSKPNK-----RKLMILITDGRS 620

Query: 153 SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIAT 188
            D++R   +A     V ++ +G   A++ EL+ IAT
Sbjct: 621 YDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIAT 656


>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
          Length = 496

 Score =  142 bits (359), Expect = 2e-33
 Identities = 108/403 (26%), Positives = 191/403 (47%), Gaps = 40/403 (9%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F++D S +   V F  +  FL  ++E L +G    RVG+V ++   +  FSL  + +
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 96  KAQVLGAVKALG-FAGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 153
           KA +L AV+ +   + G +   GLA+ F +   F  A G R     + +V+++++ G   
Sbjct: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKLLP 211
           D ++      + + V  F +G  +  +A L+ IA++  D  V  V  +     L  K   
Sbjct: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218

Query: 212 YIVGVAQ---------RHIVLKPPTIVTQVIEV--------------------NKRDIVF 242
               V+            + +  P   T                         +  D+VF
Sbjct: 219 AFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVF 278

Query: 243 LVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREV 302
           L+DGS ++   NF  ++ FI++++  L++   L QV + QY+ +VR EF      TK+++
Sbjct: 279 LIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDI 338

Query: 303 ITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQP 362
             AVR M  ++   + TG+AL ++ +N FT S+G  A  G  K+ ++ T G+S D I+  
Sbjct: 339 KAAVRNMSYMEKGTM-TGAALKYLIDNSFTVSSG--ARPGAQKVGIVFTDGRSQDYINDA 395

Query: 363 AQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFR 403
           A++ K      FA+G   A + EL EIA +  +   F  A+F+
Sbjct: 396 AKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFK 438



 Score =  139 bits (351), Expect = 1e-32
 Identities = 118/413 (28%), Positives = 199/413 (48%), Gaps = 43/413 (10%)

Query: 823  DVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
            D+VF++D S  VR   F  +K F+ +V+ESLDVG +  RV +V Y+   + EF L ++++
Sbjct: 41   DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 882  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRI-TEGVPQLLIVLTADRSGD 940
            K  ++ AVR++  L   T  TG A++F +      + G R  +  + +++IV+T  R  D
Sbjct: 101  KAALLQAVRRIQPLSTGTM-TGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159

Query: 941  DVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-----DFAVAIPTFRQLGTVQQVI 995
             V++ S   +  G     IG+G+ D   ++ I+  P     D+  +     +L    Q  
Sbjct: 160  SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219

Query: 996  SERVTQLTREELSRLQPVLQPLPSP----------------------GVGGKR--DVVFL 1031
               V+ L        + V    P                        G GG    D+VFL
Sbjct: 220  FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279

Query: 1032 IDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQ 1090
            IDGS+S  PE F+ V+  I ++VD LDV     +V ++Q+S   + EF L    +K +++
Sbjct: 280  IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339

Query: 1091 NAVQRL--RPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDD 1148
             AV+ +    KG      G AL+Y+  N F    G+R   G  +  ++ + G+S D ++D
Sbjct: 340  AAVRNMSYMEKG---TMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394

Query: 1149 PAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 1198
             A + K  G   F +   NA ++EL +I+  P  E+ F  + F+ +  + +KL
Sbjct: 395  AAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447



 Score =  132 bits (333), Expect = 2e-30
 Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 52/392 (13%)

Query: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
           D++F+ D S ++   +F  V+ FL ++I+ L+V P  TR+ +  Y+  VK E     H S
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 690 KPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVA-GRSS 747
           K  +L  V+R++ + TG     G A+ +A    F  + G R     +  +V++V  GR  
Sbjct: 101 KAALLQAVRRIQPLSTGTMT--GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQ 158

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----------------------- 784
           D V   ++  + SGV  F     + D A L QI   P                       
Sbjct: 159 DSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQE 218

Query: 785 AFILAAESLPKIGDLHPQIVNLLK------SVHNGAPAPVSGEK-------------DVV 825
           AF + ++ L   GD   + V +        + H G      G+              D+V
Sbjct: 219 AFCVVSD-LCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLV 277

Query: 826 FLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQD 884
           FL+DGS+ VR   F L+K+F+ ++V++LDV     +V +VQYS   R EF L  +  K+D
Sbjct: 278 FLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKD 337

Query: 885 VVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRN 944
           +  AVR ++ +   T  TGAAL++++ N    S+G+R   G  ++ IV T  RS D + +
Sbjct: 338 IKAAVRNMSYMEKGT-MTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYIND 394

Query: 945 PSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
            +   K  G     +G+GNA   E++ I+  P
Sbjct: 395 AAKKAKDLGFKMFAVGVGNAVEDELREIASEP 426



 Score =  129 bits (325), Expect = 1e-29
 Identities = 102/390 (26%), Positives = 179/390 (45%), Gaps = 42/390 (10%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++F++D S +V    F  V+ F+  ++ SLD+G +  RVG+V ++ T   EFSL  + +
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 551
           K+ +L  +R++Q    +G  TG A+ +     F +A G R R   + ++++++T G+ +D
Sbjct: 101 KAALLQAVRRIQ-PLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQD 159

Query: 552 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ---- 605
           S    +     +G+  F +G    +KA L QIA  P    V  ++ +S +  L ++    
Sbjct: 160 SVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEA 219

Query: 606 --LIQPLTTYVSGGVEEVPLAQP----------------------------ESKRDILFL 635
             ++  L        E+V ++ P                             S  D++FL
Sbjct: 220 FCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFL 279

Query: 636 FDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL 694
            DGS ++  + F +V+ F+ +I+D L+V  +  ++ + QYS  V+ E       +K +I 
Sbjct: 280 IDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIK 339

Query: 695 NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPA 754
             V+ M     K    G AL Y     F  S+G+R   G  +  ++   GRS D ++  A
Sbjct: 340 AAVRNMSYME-KGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQDYINDAA 396

Query: 755 SNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
              K  G   F     NA   EL +I   P
Sbjct: 397 KKAKDLGFKMFAVGVGNAVEDELREIASEP 426



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 64/198 (32%), Positives = 102/198 (51%), Gaps = 11/198 (5%)

Query: 429 SNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 488
           S+  D++FL+DGS +V   NF  V+ F+  +V++LD+ +   +VGLVQ+S +   EF L 
Sbjct: 271 SSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLG 330

Query: 489 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQ 548
            + TK DI   +R +      G  TG+AL Y+  N FT + G+  R    ++ ++ T G+
Sbjct: 331 RFHTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGA--RPGAQKVGIVFTDGR 387

Query: 549 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQL 606
           S+D    AA      G   F VG   A + EL +IA  P     +   DF ++  + ++L
Sbjct: 388 SQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447

Query: 607 IQPLTTYVSGGVEEVPLA 624
            + +       VEE P A
Sbjct: 448 QKKIC------VEEDPCA 459



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 62/215 (28%), Positives = 108/215 (50%), Gaps = 16/215 (7%)

Query: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKR----------DVVFLIDGSQSAGP-EFQYVR 1046
            RV   T   L  L  +LQ L SPG+  +           D+VF++D S+S  P EF+ V+
Sbjct: 2    RVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVK 61

Query: 1047 TLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINV 1106
              + ++++ LDVG + TRV ++ ++   K EF L AH SK  +  AV+R++P     +  
Sbjct: 62   VFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTM-T 120

Query: 1107 GNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-A 1164
            G A+++     F    G R     + + +++++ G+  D V D +   +  GV  F I  
Sbjct: 121  GLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGV 180

Query: 1165 RNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 1197
             + D+  L +I+  P  E+V  V ++  +  L +K
Sbjct: 181  GSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRK 215



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 5/178 (2%)

Query: 34  SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
           + D++FLIDGS +    NF ++  F+  +++ L +  +  +VG+VQ+S   R  F L  +
Sbjct: 273 ATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRF 332

Query: 94  STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
            TK  +  AV+ + +   +    G AL ++++N FT + G+R   G  +V ++ + G S 
Sbjct: 333 HTKKDIKAAVRNMSYM-EKGTMTGAALKYLIDNSFTVSSGAR--PGAQKVGIVFTDGRSQ 389

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDD--NLVFTVPEFRSFGDLQEKL 209
           D I       K      F +G   A   EL+ IA++      F   +F++   + +KL
Sbjct: 390 DYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKL 447


>gi|205277471 cochlin precursor [Homo sapiens]
          Length = 550

 Score =  140 bits (352), Expect = 1e-32
 Identities = 109/364 (29%), Positives = 176/364 (48%), Gaps = 22/364 (6%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           ADI FLIDGS N G   F +  +F+  +   L IGT+   VG+VQ S+ P+  F L  ++
Sbjct: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
           +   VL A+K +GF GG  +N G AL    +  FT   G  V +G+P+V+V+   G  SD
Sbjct: 224 SAKDVLFAIKEVGFRGGN-SNTGKALKHTAQKFFTVDAG--VRKGIPKVVVVFIDGWPSD 280

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAEL---QHIATDDNLVFTVPEFRSFGDLQEKLLP 211
           +I    +  ++  V  F +        EL   Q +   D  V     F S+       +P
Sbjct: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYH------MP 334

Query: 212 YIVGVAQ--RHIVLKPPT---IVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266
              G  +  + +V K  T   ++      N  +I FL+DGSS++G +NF  + +F++ + 
Sbjct: 335 NWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIA 394

Query: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
           +  EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F 
Sbjct: 395 KTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFT 453

Query: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
             N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L
Sbjct: 454 VRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDL 509

Query: 387 EEIA 390
           +++A
Sbjct: 510 KDMA 513



 Score =  138 bits (347), Expect = 4e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222

Query: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279

Query: 357 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 404
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339

Query: 405 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398

Query: 465 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 524
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457

Query: 525 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 583
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512

Query: 584 AFNP--SLVYLMDDFSSLPALPQQLIQ 608
           A  P  S  +   +F+ L  +   +I+
Sbjct: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539



 Score =  127 bits (318), Expect = 9e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 419 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 474
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206

Query: 475 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263

Query: 535 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 585
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323

Query: 586 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 642
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378

Query: 643 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 701
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438

Query: 702 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 761
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493

Query: 762 VVPFIFQAKNADPAELEQIVLSP 784
           +  F      A   +L+ +   P
Sbjct: 494 ITIFSVGVAWAPLDDLKDMASKP 516



 Score =  123 bits (308), Expect = 1e-27
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 796  IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 854
            +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 138  VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197

Query: 855  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 914
            G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 198  GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256

Query: 915  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 971
               AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 257  TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314

Query: 972  ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 1023
            ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 315  VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363

Query: 1024 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
               ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 364  NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 1142
            +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 424  YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478

Query: 1143 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 1195
             D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 479  YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 64/216 (29%), Positives = 102/216 (47%), Gaps = 22/216 (10%)

Query: 8   PLVAVFCLFLSGFPTTHAQQQ--QAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEK 65
           PLV   C        TH Q    +   +S +I FLIDGS++ G  NF ++L+F+ N+ + 
Sbjct: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396

Query: 66  LPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVE 125
             I     ++  VQF+ + RT FS   YSTK  VL  ++ + +  G  A  G A+ F V 
Sbjct: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTAT-GDAISFTVR 455

Query: 126 NHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQH 185
           N F    G   E      LV+++ G S D+++    A   A +  F +G   A   +L+ 
Sbjct: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511

Query: 186 IAT---DDNLVFTVPEFRSFGDLQEKLLPYIVGVAQ 218
           +A+   + +  FT    R F  L+  +   I G+ +
Sbjct: 512 MASKPKESHAFFT----REFTGLEPIVSDVIRGICR 543


>gi|4758022 cochlin precursor [Homo sapiens]
          Length = 550

 Score =  140 bits (352), Expect = 1e-32
 Identities = 109/364 (29%), Positives = 176/364 (48%), Gaps = 22/364 (6%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           ADI FLIDGS N G   F +  +F+  +   L IGT+   VG+VQ S+ P+  F L  ++
Sbjct: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
           +   VL A+K +GF GG  +N G AL    +  FT   G  V +G+P+V+V+   G  SD
Sbjct: 224 SAKDVLFAIKEVGFRGGN-SNTGKALKHTAQKFFTVDAG--VRKGIPKVVVVFIDGWPSD 280

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAEL---QHIATDDNLVFTVPEFRSFGDLQEKLLP 211
           +I    +  ++  V  F +        EL   Q +   D  V     F S+       +P
Sbjct: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYH------MP 334

Query: 212 YIVGVAQ--RHIVLKPPT---IVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266
              G  +  + +V K  T   ++      N  +I FL+DGSS++G +NF  + +F++ + 
Sbjct: 335 NWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIA 394

Query: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
           +  EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F 
Sbjct: 395 KTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFT 453

Query: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
             N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L
Sbjct: 454 VRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDL 509

Query: 387 EEIA 390
           +++A
Sbjct: 510 KDMA 513



 Score =  138 bits (347), Expect = 4e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222

Query: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279

Query: 357 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 404
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339

Query: 405 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398

Query: 465 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 524
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457

Query: 525 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 583
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512

Query: 584 AFNP--SLVYLMDDFSSLPALPQQLIQ 608
           A  P  S  +   +F+ L  +   +I+
Sbjct: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539



 Score =  127 bits (318), Expect = 9e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 419 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 474
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206

Query: 475 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263

Query: 535 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 585
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323

Query: 586 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 642
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378

Query: 643 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 701
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438

Query: 702 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 761
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493

Query: 762 VVPFIFQAKNADPAELEQIVLSP 784
           +  F      A   +L+ +   P
Sbjct: 494 ITIFSVGVAWAPLDDLKDMASKP 516



 Score =  123 bits (308), Expect = 1e-27
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 796  IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 854
            +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 138  VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197

Query: 855  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 914
            G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 198  GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256

Query: 915  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 971
               AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 257  TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314

Query: 972  ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 1023
            ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 315  VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363

Query: 1024 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
               ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 364  NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 1142
            +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 424  YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478

Query: 1143 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 1195
             D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 479  YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 64/216 (29%), Positives = 102/216 (47%), Gaps = 22/216 (10%)

Query: 8   PLVAVFCLFLSGFPTTHAQQQ--QAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEK 65
           PLV   C        TH Q    +   +S +I FLIDGS++ G  NF ++L+F+ N+ + 
Sbjct: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396

Query: 66  LPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVE 125
             I     ++  VQF+ + RT FS   YSTK  VL  ++ + +  G  A  G A+ F V 
Sbjct: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTAT-GDAISFTVR 455

Query: 126 NHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQH 185
           N F    G   E      LV+++ G S D+++    A   A +  F +G   A   +L+ 
Sbjct: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511

Query: 186 IAT---DDNLVFTVPEFRSFGDLQEKLLPYIVGVAQ 218
           +A+   + +  FT    R F  L+  +   I G+ +
Sbjct: 512 MASKPKESHAFFT----REFTGLEPIVSDVIRGICR 543


>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
          Length = 499

 Score =  132 bits (333), Expect = 2e-30
 Identities = 116/415 (27%), Positives = 200/415 (48%), Gaps = 40/415 (9%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F+ID S +     F  +  FL+ LL  L +G    RVGV+Q+S + +++F L  +S 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 96  KAQVLGAVKAL-GFAGGELANIGLALDFVVENHFTRAGGSRV-EEGVPQVLVLISAGPSS 153
           +  +  A++ L   A G +   GLA+ + +   F+ A G+R  EE VP+V V+++ G   
Sbjct: 94  REDMERAIRDLVPLAQGTMT--GLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEF---RSFG-DLQE 207
           D +       +   +  + +G Q A    L+ +A+   D  VF V  F   + FG   Q 
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQS 211

Query: 208 KLLPYIV---------------GVAQRHIVLKPPTIVTQVIEVNKR-----DIVFLVDGS 247
           +L    +               G++ R +  +   +       N+      D+V LVDGS
Sbjct: 212 RLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGS 271

Query: 248 SALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVR 307
            ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T  EV  AV 
Sbjct: 272 KSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVL 331

Query: 308 KMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLDEISQPAQEL 366
            ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D+IS  A   
Sbjct: 332 AVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARA 390

Query: 367 KRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLLAPLR 419
           K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL  LR
Sbjct: 391 KEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLLENLR 439



 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/434 (26%), Positives = 201/434 (46%), Gaps = 41/434 (9%)

Query: 414 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 470
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 471 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 530
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 531 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 587
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 588 SLVYLMDDFSSLPALPQQL-----IQPLTTYVSGGVEEVPLAQ--------PESKR---- 630
             V+L++ F  +     Q      ++ L   V  G E   +++        PE ++    
Sbjct: 191 EHVFLVESFDLIQEFGLQFQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQAD 250

Query: 631 ------------DILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDD 677
                       D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  
Sbjct: 251 GKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSR 310

Query: 678 VKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQ 736
           V+ E     + +  E+   V  ++    +    G AL +   + F ++ G+R     V +
Sbjct: 311 VRTEFPLGRYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPR 369

Query: 737 FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKI 796
             ++   GRS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  
Sbjct: 370 VGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDF 428

Query: 797 GDLHPQIVNLLKSV 810
           G +   + NL  S+
Sbjct: 429 GTMTHLLENLRGSI 442



 Score =  124 bits (312), Expect = 4e-28
 Identities = 103/390 (26%), Positives = 187/390 (47%), Gaps = 31/390 (7%)

Query: 819  SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
            +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30   TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 878  SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 936
            ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90   AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 937  RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQV 994
            R  D V   +   +  G     +G+  AD+  ++ ++  P  +    + +F  +      
Sbjct: 149  RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQ 208

Query: 995  ISERVT--------------QLTREELSR--LQPVLQPLPSPGVG------GKRDVVFLI 1032
               R+               Q   E LS   L P  + L + G        G  D+V L+
Sbjct: 209  FQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLV 268

Query: 1033 DGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQN 1091
            DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  + +  EV+ 
Sbjct: 269  DGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQ 328

Query: 1092 AVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGKSDDEVDDPA 1150
            AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+S D++   A
Sbjct: 329  AVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWA 387

Query: 1151 VELKQFGVAPFTI-ARNADQEELVKISLSP 1179
               K+ G+  + +    A + EL +I+  P
Sbjct: 388  ARAKEEGIVMYAVGVGKAVEAELREIASEP 417



 Score =  117 bits (292), Expect = 9e-26
 Identities = 111/398 (27%), Positives = 173/398 (43%), Gaps = 53/398 (13%)

Query: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 688
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 689 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRI-EDGVLQFLVLLVAGRSS 747
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA--FILAAESLPKIGDLHPQ--- 802
           DRV   A+  +  G+  +    + AD   L  +   P    +   ES   I +   Q   
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQS 211

Query: 803 ---IVNLLKSVHNGAPAPV----------------------------SGEKDVVFLLDGS 831
              + +L   V +G                                  G  D+V L+DGS
Sbjct: 212 RLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGS 271

Query: 832 EGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVR 890
           + VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  Y    +V  AV 
Sbjct: 272 KSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVL 331

Query: 891 QLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADRSGDDVRNPSVVV 949
            +  +   T  TG AL  ++ +    + G+R     VP++ +V T  RS DD+   +   
Sbjct: 332 AVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARA 390

Query: 950 KRGGAVPIGIGIGNADITEMQTI---------SFIPDF 978
           K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 391 KEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 428



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 1024 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31   GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 1141
             S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91   FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 1188
              D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150  PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199


>gi|93141047 collagen, type XII, alpha 1 long isoform precursor [Homo
            sapiens]
          Length = 3063

 Score =  132 bits (332), Expect = 2e-30
 Identities = 89/280 (31%), Positives = 155/280 (55%), Gaps = 19/280 (6%)

Query: 963  NADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQP---- 1016
            +A  TE      +P+  + V I ++ ++     VI     QLT +  S  +PV +     
Sbjct: 73   SASTTETLLSELVPETEYVVTITSYDEVEESVPVIG----QLTIQTGSSTKPVEKKPGKT 128

Query: 1017 -LPSPGVGGKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDP 1074
             +    V    D+VFL+DGS S G   F+Y+   I  LV   D+G + TRV V+Q+S D 
Sbjct: 129  EIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDT 188

Query: 1075 KVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFL 1134
            + EF LN +  +DE+  A++++  KGG  +  G+A++Y+ +N F    G+R+  G P+  
Sbjct: 189  RTEFNLNQYYQRDELLAAIKKIPYKGGNTMT-GDAIDYLVKNTFTESAGARV--GFPKVA 245

Query: 1135 VLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPE--YVFSVSTFREL 1191
            ++I+ GKS DEV+ PA EL+  GV  F++  + AD +EL +I+ +P   +VF+V+ F  +
Sbjct: 246  IIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAI 305

Query: 1192 PSLEQKLLTPITTLTSEQIQKLLASTR-YPPPGEMGASEV 1230
              ++ ++++ + +   EQ+ +L++      PP  + A EV
Sbjct: 306  VDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIAMEV 345



 Score =  128 bits (322), Expect = 3e-29
 Identities = 84/231 (36%), Positives = 125/231 (54%), Gaps = 16/231 (6%)

Query: 183 LQHIATDDNLVFTVPEFRSFGDLQEKLLPYI------VGVAQRHIVLKPPTIVTQVIEVN 236
           L  +  +   V T+  +    D  E+ +P I       G + + +  KP     Q   V+
Sbjct: 81  LSELVPETEYVVTITSY----DEVEESVPVIGQLTIQTGSSTKPVEKKPGKTEIQKCSVS 136

Query: 237 K-RDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNT 295
              D+VFLVDGS ++G  NF  I DFIA ++   +IG++  +V V QY+   R EF  N 
Sbjct: 137 AWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQ 196

Query: 296 HPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKS 355
           +  + E++ A++K+ P  G    TG A+D++  N FT SAG R   G PK+ ++IT GKS
Sbjct: 197 YYQRDELLAAIKKI-PYKGGNTMTGDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKS 253

Query: 356 LDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL--VFIPAEFRA 404
            DE+  PA+EL+   +  F++G K AD  EL++IA   SL  VF  A F A
Sbjct: 254 QDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDA 304



 Score =  128 bits (321), Expect = 4e-29
 Identities = 69/190 (36%), Positives = 118/190 (62%), Gaps = 9/190 (4%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++FL+DGS +VG+ NF Y+ DF+  LV++ DIG +  RVG+VQ+S    TEF+LN Y  
Sbjct: 140 DLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQ 199

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
           + ++L  ++++  +GG+ + TG A+ Y+  N FTE+ G+R+    P++ +++T G+S+D 
Sbjct: 200 RDELLAAIKKIPYKGGNTM-TGDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKSQDE 256

Query: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL--VYLMDDFSSLPALPQQLIQPL 610
               A  L   G+  F +G   A+  EL+QIA  PSL  V+ + +F ++  +  ++I   
Sbjct: 257 VEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEII--- 313

Query: 611 TTYVSGGVEE 620
            + V  GV+E
Sbjct: 314 -SQVCSGVDE 322



 Score =  124 bits (312), Expect = 4e-28
 Identities = 69/180 (38%), Positives = 109/180 (60%), Gaps = 5/180 (2%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++FL+DGS + G  NF  ILDF+  L+    IG ++ RVGVVQ+S + RT F+L+ Y  
Sbjct: 140 DLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQ 199

Query: 96  KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
           + ++L A+K + + GG     G A+D++V+N FT + G+RV  G P+V ++I+ G S DE
Sbjct: 200 RDELLAAIKKIPYKGGNTMT-GDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKSQDE 256

Query: 156 IRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNL--VFTVPEFRSFGDLQEKLLPYI 213
           +      L+   V  F LG +AA   EL+ IA+  +L  VF V  F +  D+Q +++  +
Sbjct: 257 VEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQV 316



 Score =  119 bits (299), Expect = 1e-26
 Identities = 115/453 (25%), Positives = 219/453 (48%), Gaps = 33/453 (7%)

Query: 776  ELEQIVLSPAFILAAESLPKIGDLHPQIVNLLKSVHNGA------PAPVSGEKDVVFLLD 829
            E E +V   ++    ES+P IG L  Q  +  K V             VS   D+VFL+D
Sbjct: 87   ETEYVVTITSYDEVEESVPVIGQLTIQTGSSTKPVEKKPGKTEIQKCSVSAWTDLVFLVD 146

Query: 830  GSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNA 888
            GS  V R+ F  + +F+  +V + D+G+++ RV VVQYS  TR EF LN Y  + +++ A
Sbjct: 147  GSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAA 206

Query: 889  VRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVV 948
            ++++   GG T  TG A++++++N    SAG+R+  G P++ I++T  +S D+V  P+  
Sbjct: 207  IKKIPYKGGNT-MTGDAIDYLVKNTFTESAGARV--GFPKVAIIITDGKSQDEVEIPARE 263

Query: 949  VKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQVISERVTQLTREE 1006
            ++  G     +GI  AD  E++ I+  P  +    +  F  +  +Q  I  +V     E+
Sbjct: 264  LRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQ 323

Query: 1007 LSRL---QPVLQPLPSPGVGGKRDVVFL-IDGSQSAGPEFQYVRTLIERLV----DYLDV 1058
            L  L   + V++P PS  +  +    ++ ++ + S  P   Y   L           L V
Sbjct: 324  LGELVSGEEVVEP-PSNLIAMEVSSKYVKLNWNPSPSPVTGYKVILTPMTAGSRQHALSV 382

Query: 1059 GFDTTRVAVIQFSDDPKVEFLLNAHS--SKDEVQNAVQRLRP-----KGGRQINVGNALE 1111
            G  TT ++V   S D + +  ++A    +  E  + +++ +P     +  R +++   + 
Sbjct: 383  GPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECSRGVDIKADIV 442

Query: 1112 YVSRNIFKRPLGSRIEEGVPQFL-VLISSGK-SDDEVDDPAVELKQFGVAPFTIARNADQ 1169
            ++    +   + + ++  V  FL VL+ S + S + V    V+  +     FT+ +    
Sbjct: 443  FLVDGSYSIGIANFVK--VRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKV 500

Query: 1170 EELVK-ISLSPEYVFSVSTFRELPSLEQKLLTP 1201
            E++++ I+  P    S +T + +  + +K+  P
Sbjct: 501  EDIIEAINTFPYRGGSTNTGKAMTYVREKIFVP 533



 Score =  119 bits (299), Expect = 1e-26
 Identities = 65/154 (42%), Positives = 95/154 (61%), Gaps = 3/154 (1%)

Query: 239  DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
            DIV LVDGS ++G ANF  +R FI+++++  +IG   +Q+A+AQY+   R E+  N H  
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258

Query: 299  KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
            K+ ++ AV  + P  G    TG AL+F+R   F + AG R      K+ VLIT GKS D+
Sbjct: 1259 KKSLLQAVANL-PYKGGNTLTGMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQDD 1315

Query: 359  ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 392
            +  P+++LK   +  FAIG K AD+ EL+ IA D
Sbjct: 1316 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATD 1349



 Score =  112 bits (281), Expect = 2e-24
 Identities = 66/182 (36%), Positives = 106/182 (58%), Gaps = 5/182 (2%)

Query: 431 KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTY 490
           K DI+FL+DGS ++G  NF  VR F+  LV S +I  + +++ LVQ+S  P TEF+L  +
Sbjct: 438 KADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKF 497

Query: 491 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 550
               DI+  +     +GGS  NTG A++YV    F  + GS  R +VP++++L+T G+S 
Sbjct: 498 TKVEDIIEAINTFPYRGGS-TNTGKAMTYVREKIFVPSKGS--RSNVPKVMILITDGKSS 554

Query: 551 DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQ 608
           D++   A  L  + +  F VG   A ++ELE IA  P  + V+ ++DF +   +  +L Q
Sbjct: 555 DAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQ 614

Query: 609 PL 610
            +
Sbjct: 615 SI 616



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/154 (38%), Positives = 91/154 (59%), Gaps = 3/154 (1%)

Query: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296
           K DIVFLVDGS ++G+ANF  +R F+  +++  EI  + +Q+++ QY+     EF     
Sbjct: 438 KADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKF 497

Query: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
               ++I A+    P  G +  TG A+ +VR  +F  S G R+   +PK+++LIT GKS 
Sbjct: 498 TKVEDIIEAINTF-PYRGGSTNTGKAMTYVREKIFVPSKGSRS--NVPKVMILITDGKSS 554

Query: 357 DEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           D    PA +L+ S +  FA+G K A ++ELE IA
Sbjct: 555 DAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIA 588



 Score =  109 bits (272), Expect = 2e-23
 Identities = 67/180 (37%), Positives = 103/180 (57%), Gaps = 6/180 (3%)

Query: 431  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 489
            K DI+FL D S ++G  NF  V  F+ N V   D I    I+V  VQ+SD   +EF LNT
Sbjct: 2321 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 2380

Query: 490  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 549
            Y  K+  LG L+ ++ +GG+   TG AL+++     T   G  +R++VP++L+++T G+S
Sbjct: 2381 YNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESG--MRKNVPKVLVVVTDGRS 2437

Query: 550  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLI 607
            +D   +AA  + ++G   F VG +  +  EL  IA  PS   V+++DDF S   +   LI
Sbjct: 2438 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLI 2497



 Score =  106 bits (265), Expect = 1e-22
 Identities = 79/250 (31%), Positives = 122/250 (48%), Gaps = 13/250 (5%)

Query: 990  TVQQVISERVTQLTREELSRLQPVLQPLP-----SPGVGGKRDVVFLIDGSQSAG-PEFQ 1043
            T  Q+    +  +T  E   +    QP+      S GV  K D+VFL+DGS S G   F 
Sbjct: 398  TEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFV 457

Query: 1044 YVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQ 1103
             VR  +E LV   ++  +  +++++Q+S DP  EF L   +  +++  A+     +GG  
Sbjct: 458  KVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGG-S 516

Query: 1104 INVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163
             N G A+ YV   IF    GSR    VP+ ++LI+ GKS D   DPA++L+   V  F +
Sbjct: 517  TNTGKAMTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAV 574

Query: 1164 -ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKLLTPITTLTSEQIQKLLASTRYP 1220
              ++A + EL  I+  P   +VF+V  F     +  + LT    L  EQ    +    Y 
Sbjct: 575  GVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFE-LTQSICLRIEQELAAIKKKAYV 633

Query: 1221 PPGEMGASEV 1230
            PP ++  SEV
Sbjct: 634  PPKDLSFSEV 643



 Score =  103 bits (257), Expect = 1e-21
 Identities = 60/170 (35%), Positives = 98/170 (57%), Gaps = 5/170 (2%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           ADI+FL+DGS + G  NF  +  FL  L++   I   ++++ +VQ+S +P T F+L  ++
Sbjct: 439 ADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFT 498

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
               ++ A+    + GG   N G A+ +V E  F  + GSR    VP+V++LI+ G SSD
Sbjct: 499 KVEDIIEAINTFPYRGGS-TNTGKAMTYVREKIFVPSKGSR--SNVPKVMILITDGKSSD 555

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSF 202
             R   + L+ + V  F +G + A R+EL+ IA+   +  VFTV +F +F
Sbjct: 556 AFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAF 605



 Score =  103 bits (257), Expect = 1e-21
 Identities = 71/206 (34%), Positives = 112/206 (54%), Gaps = 12/206 (5%)

Query: 1002 LTREELSRLQPV-LQPLPSPGVG----GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDY 1055
            L  +E++ L    + P+ S G+      + D+V L+DGS S G   F+ VR+ I R+V+ 
Sbjct: 1169 LVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEV 1228

Query: 1056 LDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSR 1115
             D+G    ++A+ Q+S DP+ E+ LNAH  K  +  AV  L  KGG  +  G AL ++ +
Sbjct: 1229 FDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTL-TGMALNFIRQ 1287

Query: 1116 NIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIA-RNADQEELVK 1174
              F+   G R      +  VLI+ GKS D+V+ P+ +LK  GV  F I  +NAD+ EL  
Sbjct: 1288 QNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKM 1345

Query: 1175 ISLSPE--YVFSVSTFRELPSLEQKL 1198
            I+  P+  + ++V+ F  L  +   L
Sbjct: 1346 IATDPDDTHAYNVADFESLSRIVDDL 1371



 Score =  103 bits (256), Expect = 1e-21
 Identities = 62/186 (33%), Positives = 100/186 (53%), Gaps = 5/186 (2%)

Query: 433  DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
            DI+ L+DGS ++G+ NF  VR F+  +V   DIG   +++ L Q+S  P TE+ LN ++ 
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258

Query: 493  KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
            K  +L  +  L  +GG+ L TG AL+++   +F    G R R    ++ +L+T G+S+D 
Sbjct: 1259 KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMRPRAR--KIGVLITDGKSQDD 1315

Query: 553  YLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPL 610
                +  L   G+  F +G   A++ EL+ IA +P  +  Y + DF SL  +   L   L
Sbjct: 1316 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINL 1375

Query: 611  TTYVSG 616
               V G
Sbjct: 1376 CNSVKG 1381



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 65/200 (32%), Positives = 105/200 (52%), Gaps = 6/200 (3%)

Query: 21   PTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLP-IGTQQIRVGVVQ 79
            PT    +       ADI+FL D S + G  NF  ++ F+ N +     I    I+V  VQ
Sbjct: 2308 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 2367

Query: 80   FSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEG 139
            +SDE ++ F L+TY+ KA  LGA++ + + GG     G AL F+ E   T   G R  + 
Sbjct: 2368 YSDEVKSEFKLNTYNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESGMR--KN 2424

Query: 140  VPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIAT--DDNLVFTVP 197
            VP+VLV+++ G S DE++   + ++Q+    F +G       EL +IA+   +  VF V 
Sbjct: 2425 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 2484

Query: 198  EFRSFGDLQEKLLPYIVGVA 217
            +F SF  +++ L+ ++   A
Sbjct: 2485 DFESFEKIEDNLITFVCETA 2504



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 64/190 (33%), Positives = 102/190 (53%), Gaps = 6/190 (3%)

Query: 791  ESLPKIGDLHPQI--VNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQR 847
            ES P +G     +    ++  + +G       E D+V L+DGS  + R+ F  ++ F+ R
Sbjct: 1165 ESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISR 1224

Query: 848  VVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALE 907
            +VE  D+G  RV++A+ QYS   R E+ LN++ +K+ ++ AV  L   GG T  TG AL 
Sbjct: 1225 IVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNT-LTGMALN 1283

Query: 908  FVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADIT 967
            F+ +    + AG R      ++ +++T  +S DDV  PS  +K  G     IGI NAD  
Sbjct: 1284 FIRQQNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEV 1341

Query: 968  EMQTISFIPD 977
            E++ I+  PD
Sbjct: 1342 ELKMIATDPD 1351



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 66/185 (35%), Positives = 99/185 (53%), Gaps = 8/185 (4%)

Query: 225  PPTI--VTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVAVA 281
            PPTI     V +  K DIVFL D S ++G  NFN +  FI   +    EI    IQV+  
Sbjct: 2307 PPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFV 2366

Query: 282  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 341
            QY+D V+ EF  NT+  K   + A++ ++   G+   TG AL F++  + T  +G R  +
Sbjct: 2367 QYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTR-TGKALTFIKEKVLTWESGMR--K 2423

Query: 342  GIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS--LVFIP 399
             +PK+LV++T G+S DE+ + A  +++S    F +G    D  EL  IA   S   VFI 
Sbjct: 2424 NVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIV 2483

Query: 400  AEFRA 404
             +F +
Sbjct: 2484 DDFES 2488



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 57/177 (32%), Positives = 94/177 (53%), Gaps = 5/177 (2%)

Query: 35   ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
            ADI+ L+DGS + G  NF  +  F+  ++E   IG +++++ + Q+S +PRT + L+ + 
Sbjct: 1198 ADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHR 1257

Query: 95   TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
             K  +L AV  L + GG     G+AL+F+ + +F    G R      ++ VLI+ G S D
Sbjct: 1258 DKKSLLQAVANLPYKGGNTLT-GMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQD 1314

Query: 155  EIRYGVVALKQASVFSFGLGAQAASRAELQHIAT--DDNLVFTVPEFRSFGDLQEKL 209
            ++      LK   V  F +G + A   EL+ IAT  DD   + V +F S   + + L
Sbjct: 1315 DVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 1371



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 62/212 (29%), Positives = 108/212 (50%), Gaps = 7/212 (3%)

Query: 617 GVEEVPLAQPESKRDILFLFDGSANLV-GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 675
           G  E+      +  D++FL DGS ++    F  + DF+  ++   ++  E TR+ V QYS
Sbjct: 126 GKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYS 185

Query: 676 DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
            D + E   +++  + E+L  +K++  K G  +  G A+DY  +  F +SAG+R+  G  
Sbjct: 186 SDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMT-GDAIDYLVKNTFTESAGARV--GFP 242

Query: 736 QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAF--ILAAESL 793
           +  +++  G+S D V+ PA  L+  GV  F    K AD  EL+QI  +P+   +    + 
Sbjct: 243 KVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANF 302

Query: 794 PKIGDLHPQIVN-LLKSVHNGAPAPVSGEKDV 824
             I D+  +I++ +   V       VSGE+ V
Sbjct: 303 DAIVDIQNEIISQVCSGVDEQLGELVSGEEVV 334



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 49/155 (31%), Positives = 91/155 (58%), Gaps = 4/155 (2%)

Query: 823 DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
           D+VFL+DGS  +  + F  ++ F++ +V+S ++  +RV++++VQYS     EF L  +  
Sbjct: 440 DIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTK 499

Query: 882 KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 941
            +D++ A+      GG T NTG A+ +V   I V S GSR    VP+++I++T  +S D 
Sbjct: 500 VEDIIEAINTFPYRGGST-NTGKAMTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDA 556

Query: 942 VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
            R+P++ ++        +G+ +A  +E++ I+  P
Sbjct: 557 FRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPP 591



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 32/296 (10%)

Query: 592  LMDDFSSLPALPQQLIQPLTTYV----SGGVEEVPLAQPESKRDILFLFDGSANLV-GQF 646
            + D   S P + Q++     T V    S G+E +  A+     DI+ L DGS ++    F
Sbjct: 1160 MFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEA----DIVLLVDGSWSIGRANF 1215

Query: 647  PVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGK 706
              VR F+ +I++  ++ P+  +IA+AQYS D + E + + H+ K  +L  V  +  K G 
Sbjct: 1216 RTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGN 1275

Query: 707  ALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFI 766
             L  G AL++ ++  F   AG R      +  VL+  G+S D V+ P+  LK  GV  F 
Sbjct: 1276 TLT-GMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFA 1332

Query: 767  FQAKNADPAELEQIVLSP----AFILA-AESLPKIGDLHPQIVNLLKSVHNGAPAPVSGE 821
               KNAD  EL+ I   P    A+ +A  ESL +I D     +NL  SV    P  +   
Sbjct: 1333 IGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVD--DLTINLCNSVK--GPGDLEAP 1388

Query: 822  KDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
             ++V         R  +    + V           DR +V     S   R EFY++
Sbjct: 1389 SNLVISERTHRSFRVSWTPPSDSV-----------DRYKVEYYPVSGGKRQEFYVS 1433



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 63/217 (29%), Positives = 105/217 (48%), Gaps = 9/217 (4%)

Query: 1012 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF--QYVRTLIERLVDYLDVGFDTTRVAVIQ 1069
            P + P      G K D+VFL D S S G +   + V+ +   +  + ++     +V+ +Q
Sbjct: 2308 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 2367

Query: 1070 FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 1129
            +SD+ K EF LN ++ K     A+Q +R +GG     G AL ++   +     G R  + 
Sbjct: 2368 YSDEVKSEFKLNTYNDKALALGALQNIRYRGG-NTRTGKALTFIKEKVLTWESGMR--KN 2424

Query: 1130 VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVS 1186
            VP+ LV+++ G+S DEV   A+ ++Q G + F +   + D  EL  I+  P   +VF V 
Sbjct: 2425 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 2484

Query: 1187 TFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG 1223
             F     +E  L+T +   T+     L+    Y  PG
Sbjct: 2485 DFESFEKIEDNLITFVCE-TATSSCPLIYLDGYTSPG 2520



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 11/178 (6%)

Query: 801  PQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLD-VGQDR 858
            P  +   + V  GA A      D+VFL D S  +    F  + +F+   V   D +    
Sbjct: 2307 PPTIPPARDVCKGAKA------DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 2360

Query: 859  VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 918
            ++V+ VQYSD  + EF LN+Y +K   + A++ +   GG T  TG AL F+   +L   +
Sbjct: 2361 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWES 2419

Query: 919  GSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
            G R  + VP++L+V+T  RS D+V+  ++V+++ G     +G+ + D  E+  I+  P
Sbjct: 2420 GMR--KNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKP 2475



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 62/192 (32%), Positives = 90/192 (46%), Gaps = 14/192 (7%)

Query: 597 SSLPALPQQLIQPLTTYV--SGGVEEVPLAQPESKRDILFLFDGSANL-VGQFPVVRDFL 653
           SS P    +  QP+   V  S GV+         K DI+FL DGS ++ +  F  VR FL
Sbjct: 412 SSEPISIMEKTQPMKVQVECSRGVD--------IKADIVFLVDGSYSIGIANFVKVRAFL 463

Query: 654 YKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYA 713
             ++    + P   +I++ QYS D   E    +     +I+  +     + G   N G A
Sbjct: 464 EVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGST-NTGKA 522

Query: 714 LDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNAD 773
           + Y +  IFV S GSR    V + ++L+  G+SSD    PA  L+ S V  F    K+A 
Sbjct: 523 MTYVREKIFVPSKGSR--SNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAV 580

Query: 774 PAELEQIVLSPA 785
            +ELE I   PA
Sbjct: 581 RSELEAIASPPA 592



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 10/178 (5%)

Query: 628  SKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFD 685
            +K DI+FL D S ++    F  V  F++  +   + + P G +++  QYSD+VK E + +
Sbjct: 2320 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 2379

Query: 686  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745
             +  K   L  ++ ++ + G     G AL + +  +    +G R    V + LV++  GR
Sbjct: 2380 TYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGR 2436

Query: 746  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA----FIL-AAESLPKIGD 798
            S D V   A  ++QSG   F+    + D  EL  I   P+    FI+   ES  KI D
Sbjct: 2437 SQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIED 2494


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score =  129 bits (324), Expect = 2e-29
 Identities = 90/254 (35%), Positives = 138/254 (54%), Gaps = 29/254 (11%)

Query: 422 SGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTP 481
           +G   VH    D++FLLD S++VGK +F  VR +V NLV++ ++G D  RVG+V++SD P
Sbjct: 30  AGCKSVHY---DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRP 86

Query: 482 VTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV-PQL 540
            T F L  + ++ ++    R+L   GG+  NTG AL Y+ A  F+   G R R+    Q+
Sbjct: 87  TTAFELGLFGSQEEVKAAARRLAYHGGN-TNTGDALRYITARSFSPHAGGRPRDRAYKQV 145

Query: 541 LLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSS 598
            +LLT G+S+D  L AA A  RAGI  F VG  +A K ELE+IA  P  + V+ + DF++
Sbjct: 146 AILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNA 205

Query: 599 LPALPQQLIQPLT---------------TYVSGGVEEV---PLAQPESKRDILFLFDGSA 640
           +  +  +L + L                 + +GG +E+    L    S ++IL   +  A
Sbjct: 206 IDKIRGKLRRRLCENVLCPSVRVEGDRFKHTNGGTKEITGFDLMDLFSVKEILGKRENGA 265

Query: 641 N----LVGQFPVVR 650
                 +G FPVV+
Sbjct: 266 QSSYVRMGSFPVVQ 279



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 66/177 (37%), Positives = 96/177 (54%), Gaps = 6/177 (3%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D+VFL+D S S G E F+ VR  +  LVD  +VG D TRV V+++SD P   F L    S
Sbjct: 38   DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGKSDD 1144
            ++EV+ A +RL   GG   N G+AL Y++   F    G R  +    Q  +L++ G+S D
Sbjct: 98   QEEVKAAARRLAYHGG-NTNTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQD 156

Query: 1145 EVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFRELPSLEQKL 1198
             V D A    + G+  F +    A +EEL +I+  P+  +VF VS F  +  +  KL
Sbjct: 157  LVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNAIDKIRGKL 213



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 60/198 (30%), Positives = 101/198 (51%), Gaps = 4/198 (2%)

Query: 15  LFLSGFPTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIR 74
           L  SG     AQ+        D++FL+D S++ G  +F  +  ++ NL++   +G  + R
Sbjct: 17  LLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTR 76

Query: 75  VGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFT-RAGG 133
           VGVV++SD P T F L  + ++ +V  A + L + GG   N G AL ++    F+  AGG
Sbjct: 77  VGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGN-TNTGDALRYITARSFSPHAGG 135

Query: 134 SRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNL- 192
              +    QV +L++ G S D +     A  +A +  F +G   A + EL+ IA++    
Sbjct: 136 RPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSA 195

Query: 193 -VFTVPEFRSFGDLQEKL 209
            VF V +F +   ++ KL
Sbjct: 196 HVFHVSDFNAIDKIRGKL 213



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 64/180 (35%), Positives = 94/180 (52%), Gaps = 7/180 (3%)

Query: 806 LLKSVHNGAPAPVSGEK----DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVR 860
           LL S   G  A  +G K    D+VFLLD S  V +  F  ++++V  +V++ +VG DR R
Sbjct: 17  LLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTR 76

Query: 861 VAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGS 920
           V VV+YSDR    F L  + ++++V  A R+L   GG T NTG AL ++        AG 
Sbjct: 77  VGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNT-NTGDALRYITARSFSPHAGG 135

Query: 921 RITE-GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFA 979
           R  +    Q+ I+LT  RS D V + +    R G     +G+G A   E++ I+  P  A
Sbjct: 136 RPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSA 195



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 62/201 (30%), Positives = 102/201 (50%), Gaps = 10/201 (4%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VFL+D SS++G  +F  +R ++A ++   E+G D  +V V +Y+D     F      +
Sbjct: 38  DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE-GIPKLLVLITGGKSLD 357
           + EV  A R++    G    TG AL ++    F+  AG R  +    ++ +L+T G+S D
Sbjct: 98  QEEVKAAARRL-AYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQD 156

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SSLVFIPAEFRAA-PLQGML--- 411
            +   A    R+ I  FA+G   A + ELEEIA +  S+ VF  ++F A   ++G L   
Sbjct: 157 LVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNAIDKIRGKLRRR 216

Query: 412 --PGLLAPLRTLSGTPEVHSN 430
               +L P   + G    H+N
Sbjct: 217 LCENVLCPSVRVEGDRFKHTN 237



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)

Query: 631 DILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
           D++FL D S+++  + F  VR ++  ++D   V P+ TR+ V +YSD            S
Sbjct: 38  DLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGS 97

Query: 690 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAGRSSD 748
           + E+    +R+    G   N G AL Y     F   AG R  D    Q  +LL  GRS D
Sbjct: 98  QEEVKAAARRLAYHGGNT-NTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQD 156

Query: 749 RVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
            V   A+   ++G+  F      A   ELE+I   P
Sbjct: 157 LVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEP 192


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score =  129 bits (323), Expect = 2e-29
 Identities = 84/217 (38%), Positives = 127/217 (58%), Gaps = 9/217 (4%)

Query: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D+V L+DGS S G   F+ VR  +E LV   DVG + TR+ + Q+S DP++E+ LNA S+
Sbjct: 158  DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
            KDEV  AV+ L  KGG  +  G AL Y+  N FK   GSR   GV +  +LI+ GKS D+
Sbjct: 218  KDEVIEAVRNLPYKGGNTL-TGLALNYIFENSFKPEAGSR--TGVSKIGILITDGKSQDD 274

Query: 1146 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFRELPSLEQKLLTPI 1202
            +  P+  L++ GV  F I  +NAD  EL +I+  P+  +V++V+ F  + ++ + L   +
Sbjct: 275  IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTL 334

Query: 1203 TTLTSEQIQKLLASTR--YPPPGEMGASEVLLGAFSI 1237
             +   EQ +++ AS      PP E+  SEV   +F +
Sbjct: 335  CSRVEEQDREIKASAHAITGPPTELITSEVTARSFMV 371



 Score =  119 bits (297), Expect = 2e-26
 Identities = 88/296 (29%), Positives = 149/296 (50%), Gaps = 36/296 (12%)

Query: 345 KLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAE--F 402
           KLLV  T G   ++++     L+ ++  A   G        ++ IA++      PA+  F
Sbjct: 61  KLLVTPTSGGKTNQLN-----LQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQF 115

Query: 403 RAAPLQ----------------GMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGK 446
           R   L+                G  P     ++ +  TP +     DI+ L+DGS ++G+
Sbjct: 116 RIKDLEKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAI----ADIVILVDGSWSIGR 171

Query: 447 TNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQ 506
            NF  VR F+ NLV + D+G++  R+GL Q+S  P  E+ LN + TK +++  +R L  +
Sbjct: 172 FNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYK 231

Query: 507 GGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGIL 566
           GG+ L TG AL+Y++ N F    GS  R  V ++ +L+T G+S+D  +  +  L  +G+ 
Sbjct: 232 GGNTL-TGLALNYIFENSFKPEAGS--RTGVSKIGILITDGKSQDDIIPPSRNLRESGVE 288

Query: 567 TFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEE 620
            F +G   A+  EL++IA  P  + VY + +F     L   +++ LT  +   VEE
Sbjct: 289 LFAIGVKNADVNELQEIASEPDSTHVYNVAEFD----LMHTVVESLTRTLCSRVEE 340



 Score =  119 bits (297), Expect = 2e-26
 Identities = 70/166 (42%), Positives = 100/166 (60%), Gaps = 5/166 (3%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           DIV LVDGS ++G  NF  +R F+  ++   ++G +  ++ +AQY+   R E++ N   T
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
           K EVI AVR + P  G    TG AL+++  N F   AG R   G+ K+ +LIT GKS D+
Sbjct: 218 KDEVIEAVRNL-PYKGGNTLTGLALNYIFENSFKPEAGSRT--GVSKIGILITDGKSQDD 274

Query: 359 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAF--DSSLVFIPAEF 402
           I  P++ L+ S +  FAIG K AD  EL+EIA   DS+ V+  AEF
Sbjct: 275 IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEF 320



 Score =  112 bits (280), Expect = 2e-24
 Identities = 71/185 (38%), Positives = 108/185 (58%), Gaps = 8/185 (4%)

Query: 225  PPTI--VTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVAVA 281
            PPTI    +V +  K D+VF+VDGS ++G  NFN I  F+   +  L +IG D  QVA+ 
Sbjct: 1016 PPTIPPAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMV 1075

Query: 282  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 341
            Q+ D  R EF  N + TK  ++ A++ +    G+   TG A+ +VR+ LFT+ +G R   
Sbjct: 1076 QFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTK-TGKAIKYVRDTLFTAESGTR--R 1132

Query: 342  GIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSL--VFIP 399
            GIPK++V+IT G+S D++++ ++E++      FAIG   AD +EL  I    S   VF  
Sbjct: 1133 GIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFV 1192

Query: 400  AEFRA 404
             +F A
Sbjct: 1193 DDFDA 1197



 Score =  112 bits (280), Expect = 2e-24
 Identities = 61/180 (33%), Positives = 105/180 (58%), Gaps = 6/180 (3%)

Query: 431  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 489
            K D++F++DGS ++G  NF  +  F+ + V +L+ IG D  +V +VQF+D P TEF LN 
Sbjct: 1030 KADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNA 1089

Query: 490  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 549
            Y+TK  +L  ++ +  +GG+   TG A+ YV    FT   G+  R  +P++++++T G+S
Sbjct: 1090 YKTKETLLDAIKHISYKGGN-TKTGKAIKYVRDTLFTAESGT--RRGIPKVIVVITDGRS 1146

Query: 550  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSL--VYLMDDFSSLPALPQQLI 607
            +D   + +  +   G   F +G + A+ +EL  I   PS   V+ +DDF +   +  +LI
Sbjct: 1147 QDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELI 1206



 Score =  111 bits (277), Expect = 5e-24
 Identities = 79/229 (34%), Positives = 123/229 (53%), Gaps = 19/229 (8%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           ADI+ L+DGS + G  NF ++  FL NL+    +G+++ R+G+ Q+S +PR  + L+ +S
Sbjct: 157 ADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFS 216

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
           TK +V+ AV+ L + GG     GLAL+++ EN F    GSR   GV ++ +LI+ G S D
Sbjct: 217 TKDEVIEAVRNLPYKGGNTLT-GLALNYIFENSFKPEAGSRT--GVSKIGILITDGKSQD 273

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAELQHIAT--DDNLVFTVPEFRSFGDLQEKLLPY 212
           +I      L+++ V  F +G + A   ELQ IA+  D   V+ V EF     + E L   
Sbjct: 274 DIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRT 333

Query: 213 IVG---------VAQRHIVLKPPT-IVTQVIEVNKRDIVFLVDGSSALG 251
           +            A  H +  PPT ++T   EV  R   F+V+ + A G
Sbjct: 334 LCSRVEEQDREIKASAHAITGPPTELITS--EVTARS--FMVNWTHAPG 378



 Score =  110 bits (275), Expect = 8e-24
 Identities = 75/232 (32%), Positives = 122/232 (52%), Gaps = 10/232 (4%)

Query: 976  PDFAVAIPTFRQLGTVQ--QVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLID 1033
            PD    I  + +L  ++   V     TQ          P + P        K D+VF++D
Sbjct: 979  PDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIPPAKEVCKAAKADLVFMVD 1038

Query: 1034 GSQSAGPE-FQYVRTLIERLVDYLD-VGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQN 1091
            GS S G E F  + + +   V  L+ +G D T+VA++QF+DDP+ EF LNA+ +K+ + +
Sbjct: 1039 GSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLD 1098

Query: 1092 AVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAV 1151
            A++ +  KGG     G A++YV   +F    G+R   G+P+ +V+I+ G+S D+V+  + 
Sbjct: 1099 AIKHISYKGG-NTKTGKAIKYVRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISR 1155

Query: 1152 ELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKLLT 1200
            E++  G + F I   +AD  ELV I   P   +VF V  F     +E +L+T
Sbjct: 1156 EMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELIT 1207



 Score =  107 bits (266), Expect = 9e-23
 Identities = 69/192 (35%), Positives = 106/192 (55%), Gaps = 13/192 (6%)

Query: 823  DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
            D+V L+DGS  + R  F L++ F++ +V + DVG ++ R+ + QYS   R E++LN++  
Sbjct: 158  DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 882  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 941
            K +V+ AVR L   GG T  TG AL ++  N     AGSR   GV ++ I++T  +S DD
Sbjct: 218  KDEVIEAVRNLPYKGGNT-LTGLALNYIFENSFKPEAGSR--TGVSKIGILITDGKSQDD 274

Query: 942  VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISERV 999
            +  PS  ++  G     IG+ NAD+ E+Q I+  PD      +  F  + TV       V
Sbjct: 275  IIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTV-------V 327

Query: 1000 TQLTREELSRLQ 1011
              LTR   SR++
Sbjct: 328  ESLTRTLCSRVE 339



 Score =  104 bits (260), Expect = 5e-22
 Identities = 64/200 (32%), Positives = 109/200 (54%), Gaps = 6/200 (3%)

Query: 21   PTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKL-PIGTQQIRVGVVQ 79
            PT    ++      AD++F++DGS + G  NF  I+ FL + +  L  IGT   +V +VQ
Sbjct: 1017 PTIPPAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQ 1076

Query: 80   FSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEG 139
            F+D+PRT F L+ Y TK  +L A+K + + GG     G A+ +V +  FT   G+R   G
Sbjct: 1077 FTDDPRTEFKLNAYKTKETLLDAIKHISYKGGN-TKTGKAIKYVRDTLFTAESGTR--RG 1133

Query: 140  VPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNL--VFTVP 197
            +P+V+V+I+ G S D++      ++      F +G   A  +EL  I +  +   VF V 
Sbjct: 1134 IPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVD 1193

Query: 198  EFRSFGDLQEKLLPYIVGVA 217
            +F +F  ++++L+ ++   A
Sbjct: 1194 DFDAFKKIEDELITFVCETA 1213



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 62/168 (36%), Positives = 91/168 (54%), Gaps = 5/168 (2%)

Query: 619 EEVP-LAQPESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSD 676
           EEV  + Q  +  DI+ L DGS ++    F +VR FL  ++   +V  E TRI +AQYS 
Sbjct: 145 EEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSG 204

Query: 677 DVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQ 736
           D ++E   +   +K E++  V+ +  K G  L  G AL+Y     F   AGSR   GV +
Sbjct: 205 DPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLT-GLALNYIFENSFKPEAGSR--TGVSK 261

Query: 737 FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
             +L+  G+S D +  P+ NL++SGV  F    KNAD  EL++I   P
Sbjct: 262 IGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEP 309



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 60/188 (31%), Positives = 104/188 (55%), Gaps = 11/188 (5%)

Query: 791  ESLPKIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVV 849
            +SLP      P  +   K V   A A      D+VF++DGS  +    F  +  F+   V
Sbjct: 1006 QSLPTRPPTFPPTIPPAKEVCKAAKA------DLVFMVDGSWSIGDENFNKIISFLYSTV 1059

Query: 850  ESLD-VGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEF 908
             +L+ +G D  +VA+VQ++D  R EF LN+Y  K+ +++A++ ++  GG T  TG A+++
Sbjct: 1060 GALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNT-KTGKAIKY 1118

Query: 909  VLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITE 968
            V   +  + +G+R   G+P++++V+T  RS DDV   S  ++  G     IG+ +AD +E
Sbjct: 1119 VRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSE 1176

Query: 969  MQTISFIP 976
            + +I   P
Sbjct: 1177 LVSIGSKP 1184



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 55/198 (27%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 590  VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPV 648
            V +M+   SLP  P     P         +EV  A   +K D++F+ DGS ++  + F  
Sbjct: 999  VSIMEKTQSLPTRP-----PTFPPTIPPAKEVCKA---AKADLVFMVDGSWSIGDENFNK 1050

Query: 649  VRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKA 707
            +  FLY  +  LN +  +GT++A+ Q++DD + E + + +++K  +L+ +K +  K G  
Sbjct: 1051 IISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNT 1110

Query: 708  LNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIF 767
               G A+ Y +  +F   +G+R   G+ + +V++  GRS D V+  +  ++  G   F  
Sbjct: 1111 -KTGKAIKYVRDTLFTAESGTR--RGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAI 1167

Query: 768  QAKNADPAELEQIVLSPA 785
               +AD +EL  I   P+
Sbjct: 1168 GVADADYSELVSIGSKPS 1185


>gi|93141049 collagen, type XII, alpha 1 short isoform precursor
           [Homo sapiens]
          Length = 1899

 Score =  119 bits (299), Expect = 1e-26
 Identities = 65/154 (42%), Positives = 95/154 (61%), Gaps = 3/154 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           DIV LVDGS ++G ANF  +R FI+++++  +IG   +Q+A+AQY+   R E+  N H  
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
           K+ ++ AV  + P  G    TG AL+F+R   F + AG R      K+ VLIT GKS D+
Sbjct: 95  KKSLLQAVANL-PYKGGNTLTGMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQDD 151

Query: 359 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 392
           +  P+++LK   +  FAIG K AD+ EL+ IA D
Sbjct: 152 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATD 185



 Score =  109 bits (272), Expect = 2e-23
 Identities = 67/180 (37%), Positives = 103/180 (57%), Gaps = 6/180 (3%)

Query: 431  KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD-IGNDNIRVGLVQFSDTPVTEFSLNT 489
            K DI+FL D S ++G  NF  V  F+ N V   D I    I+V  VQ+SD   +EF LNT
Sbjct: 1157 KADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNT 1216

Query: 490  YQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQS 549
            Y  K+  LG L+ ++ +GG+   TG AL+++     T   G  +R++VP++L+++T G+S
Sbjct: 1217 YNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESG--MRKNVPKVLVVVTDGRS 1273

Query: 550  EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLI 607
            +D   +AA  + ++G   F VG +  +  EL  IA  PS   V+++DDF S   +   LI
Sbjct: 1274 QDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLI 1333



 Score =  103 bits (256), Expect = 1e-21
 Identities = 62/186 (33%), Positives = 100/186 (53%), Gaps = 5/186 (2%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           DI+ L+DGS ++G+ NF  VR F+  +V   DIG   +++ L Q+S  P TE+ LN ++ 
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
           K  +L  +  L  +GG+ L TG AL+++   +F    G R R    ++ +L+T G+S+D 
Sbjct: 95  KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMRPRAR--KIGVLITDGKSQDD 151

Query: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQLIQPL 610
               +  L   G+  F +G   A++ EL+ IA +P  +  Y + DF SL  +   L   L
Sbjct: 152 VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINL 211

Query: 611 TTYVSG 616
              V G
Sbjct: 212 CNSVKG 217



 Score =  102 bits (255), Expect = 2e-21
 Identities = 65/176 (36%), Positives = 99/176 (56%), Gaps = 7/176 (3%)

Query: 1027 DVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D+V L+DGS S G   F+ VR+ I R+V+  D+G    ++A+ Q+S DP+ E+ LNAH  
Sbjct: 35   DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
            K  +  AV  L  KGG  +  G AL ++ +  F+   G R      +  VLI+ GKS D+
Sbjct: 95   KKSLLQAVANLPYKGGNTL-TGMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKSQDD 151

Query: 1146 VDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPE--YVFSVSTFRELPSLEQKL 1198
            V+ P+ +LK  GV  F I  +NAD+ EL  I+  P+  + ++V+ F  L  +   L
Sbjct: 152  VEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 207



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 65/200 (32%), Positives = 105/200 (52%), Gaps = 6/200 (3%)

Query: 21   PTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLP-IGTQQIRVGVVQ 79
            PT    +       ADI+FL D S + G  NF  ++ F+ N +     I    I+V  VQ
Sbjct: 1144 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 1203

Query: 80   FSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEG 139
            +SDE ++ F L+TY+ KA  LGA++ + + GG     G AL F+ E   T   G R  + 
Sbjct: 1204 YSDEVKSEFKLNTYNDKALALGALQNIRYRGGN-TRTGKALTFIKEKVLTWESGMR--KN 1260

Query: 140  VPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIAT--DDNLVFTVP 197
            VP+VLV+++ G S DE++   + ++Q+    F +G       EL +IA+   +  VF V 
Sbjct: 1261 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 1320

Query: 198  EFRSFGDLQEKLLPYIVGVA 217
            +F SF  +++ L+ ++   A
Sbjct: 1321 DFESFEKIEDNLITFVCETA 1340



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 63/174 (36%), Positives = 96/174 (55%), Gaps = 5/174 (2%)

Query: 806 LLKSVH-NGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAV 863
           LL S+   G       E D+V L+DGS  + R+ F  ++ F+ R+VE  D+G  RV++A+
Sbjct: 17  LLSSIEAEGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIAL 76

Query: 864 VQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRIT 923
            QYS   R E+ LN++ +K+ ++ AV  L   GG T  TG AL F+ +    + AG R  
Sbjct: 77  AQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNT-LTGMALNFIRQQNFRTQAGMR-- 133

Query: 924 EGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPD 977
               ++ +++T  +S DDV  PS  +K  G     IGI NAD  E++ I+  PD
Sbjct: 134 PRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPD 187



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 66/185 (35%), Positives = 99/185 (53%), Gaps = 8/185 (4%)

Query: 225  PPTI--VTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRL-EIGQDLIQVAVA 281
            PPTI     V +  K DIVFL D S ++G  NFN +  FI   +    EI    IQV+  
Sbjct: 1143 PPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFV 1202

Query: 282  QYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAE 341
            QY+D V+ EF  NT+  K   + A++ ++   G+   TG AL F++  + T  +G R  +
Sbjct: 1203 QYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTR-TGKALTFIKEKVLTWESGMR--K 1259

Query: 342  GIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS--LVFIP 399
             +PK+LV++T G+S DE+ + A  +++S    F +G    D  EL  IA   S   VFI 
Sbjct: 1260 NVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIV 1319

Query: 400  AEFRA 404
             +F +
Sbjct: 1320 DDFES 1324



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 57/177 (32%), Positives = 94/177 (53%), Gaps = 5/177 (2%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           ADI+ L+DGS + G  NF  +  F+  ++E   IG +++++ + Q+S +PRT + L+ + 
Sbjct: 34  ADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHR 93

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
            K  +L AV  L + GG     G+AL+F+ + +F    G R      ++ VLI+ G S D
Sbjct: 94  DKKSLLQAVANLPYKGGNTLT-GMALNFIRQQNFRTQAGMRPR--ARKIGVLITDGKSQD 150

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAELQHIAT--DDNLVFTVPEFRSFGDLQEKL 209
           ++      LK   V  F +G + A   EL+ IAT  DD   + V +F S   + + L
Sbjct: 151 DVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDL 207



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 77/256 (30%), Positives = 119/256 (46%), Gaps = 24/256 (9%)

Query: 628 SKRDILFLFDGSANLV-GQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDE 686
           ++ DI+ L DGS ++    F  VR F+ +I++  ++ P+  +IA+AQYS D + E + + 
Sbjct: 32  AEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNA 91

Query: 687 HQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRS 746
           H+ K  +L  V  +  K G  L  G AL++ ++  F   AG R      +  VL+  G+S
Sbjct: 92  HRDKKSLLQAVANLPYKGGNTLT-GMALNFIRQQNFRTQAGMR--PRARKIGVLITDGKS 148

Query: 747 SDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP----AFILA-AESLPKIGDLHP 801
            D V+ P+  LK  GV  F    KNAD  EL+ I   P    A+ +A  ESL +I D   
Sbjct: 149 QDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVD--D 206

Query: 802 QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 861
             +NL  SV    P  +    ++V         R  +    + V           DR +V
Sbjct: 207 LTINLCNSVK--GPGDLEAPSNLVISERTHRSFRVSWTPPSDSV-----------DRYKV 253

Query: 862 AVVQYSDRTRPEFYLN 877
                S   R EFY++
Sbjct: 254 EYYPVSGGKRQEFYVS 269



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 63/217 (29%), Positives = 105/217 (48%), Gaps = 9/217 (4%)

Query: 1012 PVLQPLPSPGVGGKRDVVFLIDGSQSAGPEF--QYVRTLIERLVDYLDVGFDTTRVAVIQ 1069
            P + P      G K D+VFL D S S G +   + V+ +   +  + ++     +V+ +Q
Sbjct: 1144 PTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQ 1203

Query: 1070 FSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEG 1129
            +SD+ K EF LN ++ K     A+Q +R +GG     G AL ++   +     G R  + 
Sbjct: 1204 YSDEVKSEFKLNTYNDKALALGALQNIRYRGG-NTRTGKALTFIKEKVLTWESGMR--KN 1260

Query: 1130 VPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVS 1186
            VP+ LV+++ G+S DEV   A+ ++Q G + F +   + D  EL  I+  P   +VF V 
Sbjct: 1261 VPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVD 1320

Query: 1187 TFRELPSLEQKLLTPITTLTSEQIQKLLASTRYPPPG 1223
             F     +E  L+T +   T+     L+    Y  PG
Sbjct: 1321 DFESFEKIEDNLITFVCE-TATSSCPLIYLDGYTSPG 1356



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 11/178 (6%)

Query: 801  PQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLD-VGQDR 858
            P  +   + V  GA A      D+VFL D S  +    F  + +F+   V   D +    
Sbjct: 1143 PPTIPPARDVCKGAKA------DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 1196

Query: 859  VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 918
            ++V+ VQYSD  + EF LN+Y +K   + A++ +   GG T  TG AL F+   +L   +
Sbjct: 1197 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWES 1255

Query: 919  GSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
            G R  + VP++L+V+T  RS D+V+  ++V+++ G     +G+ + D  E+  I+  P
Sbjct: 1256 GMR--KNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKP 1311



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 10/178 (5%)

Query: 628  SKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELN-VKPEGTRIAVAQYSDDVKVESRFD 685
            +K DI+FL D S ++    F  V  F++  +   + + P G +++  QYSD+VK E + +
Sbjct: 1156 AKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLN 1215

Query: 686  EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745
             +  K   L  ++ ++ + G     G AL + +  +    +G R    V + LV++  GR
Sbjct: 1216 TYNDKALALGALQNIRYRGGNT-RTGKALTFIKEKVLTWESGMR--KNVPKVLVVVTDGR 1272

Query: 746  SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA----FIL-AAESLPKIGD 798
            S D V   A  ++QSG   F+    + D  EL  I   P+    FI+   ES  KI D
Sbjct: 1273 SQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIED 1330


>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
          Length = 1284

 Score =  111 bits (277), Expect = 5e-24
 Identities = 68/197 (34%), Positives = 113/197 (57%), Gaps = 6/197 (3%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++FL+DGS ++G ++F  V+DF+ +++   +IG D ++VGL Q+S    TE+ LN+  T
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
           K  +L  +R+L+ +GG+   TG AL++V   +   A G  +R    ++++L+T G+S+D 
Sbjct: 239 KEQVLAAVRRLRYKGGNTF-TGLALTHVLGQNLQPAAG--LRPEAAKVVILVTDGKSQDD 295

Query: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLIQPL 610
              AA  L   G+  F VG   A++AEL  +A  P    V+ + DF  L AL   L + +
Sbjct: 296 VHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLI 355

Query: 611 TTYVSGG-VEEVPLAQP 626
              + GG   + P A P
Sbjct: 356 CQRLQGGSPRQGPAAAP 372



 Score =  109 bits (272), Expect = 2e-23
 Identities = 70/190 (36%), Positives = 107/190 (56%), Gaps = 7/190 (3%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VFLVDGS ++G ++F  ++DF+A VI   EIG D +QV + QY+   + E+  N+  T
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
           K +V+ AVR+++   G   +TG AL  V       +AG R      K+++L+T GKS D+
Sbjct: 239 KEQVLAAVRRLR-YKGGNTFTGLALTHVLGQNLQPAAGLRPEAA--KVVILVTDGKSQDD 295

Query: 359 ISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPL 418
           +   A+ LK   +  FA+G K AD+AEL  +A     + + +      L G L GLL+ L
Sbjct: 296 VHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQL-GALAGLLSRL 354

Query: 419 ---RTLSGTP 425
              R   G+P
Sbjct: 355 ICQRLQGGSP 364



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 61/173 (35%), Positives = 98/173 (56%), Gaps = 5/173 (2%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94
           AD++FL+DGS + G  +F  + DFL +++    IG  +++VG+ Q+S + +T + L++ S
Sbjct: 178 ADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLS 237

Query: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154
           TK QVL AV+ L + GG     GLAL  V+  +   A G R E    +V++L++ G S D
Sbjct: 238 TKEQVLAAVRRLRYKGGNTFT-GLALTHVLGQNLQPAAGLRPE--AAKVVILVTDGKSQD 294

Query: 155 EIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDL 205
           ++      LK   V  F +G + A  AEL+ +A+   D  V +V +F   G L
Sbjct: 295 DVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGAL 347



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/205 (34%), Positives = 111/205 (54%), Gaps = 10/205 (4%)

Query: 823  DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
            D+VFL+DGS  +  S F  +K+F+  V+   ++G D+V+V + QYS   + E+ LNS   
Sbjct: 179  DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 882  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 941
            K+ V+ AVR+L   GG T  TG AL  VL   L  +AG R      +++I++T  +S DD
Sbjct: 239  KEQVLAAVRRLRYKGGNT-FTGLALTHVLGQNLQPAAGLR--PEAAKVVILVTDGKSQDD 295

Query: 942  VRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP-DFAV-AIPTFRQLGTVQQVISERV 999
            V   + V+K  G     +G+ NAD  E++ ++  P D  V ++  F QLG +  ++S  +
Sbjct: 296  VHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLI 355

Query: 1000 TQLTREELSR----LQPVLQPLPSP 1020
             Q  +    R      P L  LP+P
Sbjct: 356  CQRLQGGSPRQGPAAAPALDTLPAP 380



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 66/185 (35%), Positives = 101/185 (54%), Gaps = 14/185 (7%)

Query: 1014 LQPLPSPGVGGKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSD 1072
            L P+P+       D+VFL+DGS S G   FQ V+  +  ++   ++G D  +V + Q+S 
Sbjct: 173  LPPVPA-------DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSG 225

Query: 1073 DPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ 1132
            D + E+ LN+ S+K++V  AV+RLR KGG     G AL +V     +   G R E    +
Sbjct: 226  DAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTF-TGLALTHVLGQNLQPAAGLRPE--AAK 282

Query: 1133 FLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPE--YVFSVSTFR 1189
             ++L++ GKS D+V   A  LK  GV  F +  +NAD+ EL  ++  P    V SV  F 
Sbjct: 283  VVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFL 342

Query: 1190 ELPSL 1194
            +L +L
Sbjct: 343  QLGAL 347



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 55/188 (29%), Positives = 85/188 (45%), Gaps = 9/188 (4%)

Query: 603 PQQLIQPLTTYVSGGVEEVPLAQ-----PESKRDILFLFDGSANLV-GQFPVVRDFLYKI 656
           P+Q  +P   +        P        P    D++FL DGS ++    F  V+DFL  +
Sbjct: 146 PEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASV 205

Query: 657 IDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDY 716
           I    + P+  ++ + QYS D + E   +   +K ++L  V+R++ K G     G AL +
Sbjct: 206 IAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTFT-GLALTH 264

Query: 717 AQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAE 776
                   +AG R E    + ++L+  G+S D V   A  LK  GV  F    KNAD AE
Sbjct: 265 VLGQNLQPAAGLRPE--AAKVVILVTDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAE 322

Query: 777 LEQIVLSP 784
           L  +   P
Sbjct: 323 LRLLASPP 330


>gi|38348304 von Willebrand factor A domain containing 2 [Homo
           sapiens]
          Length = 725

 Score =  110 bits (274), Expect = 1e-23
 Identities = 92/347 (26%), Positives = 163/347 (46%), Gaps = 11/347 (3%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D++FL+D S+   L  F   + F+ + ++ +       +V VA Y+  +        +  
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPK-LLVLITGGKSLD 357
             +++ ++  + P  G    TGSAL       F S+   R  +  P+ ++VL+T   S D
Sbjct: 403 VPDLVWSLDGI-PFRGGPTLTGSALRQAAERGFGSAT--RTGQDRPRRVVVLLTESHSED 459

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAP 417
           E++ PA+  +   ++   +G++ A +AELEEI      V + ++     L   +P L   
Sbjct: 460 EVAGPARHARARELLLLGVGSE-AVRAELEEITGSPKHVMVYSD--PQDLFNQIPELQGK 516

Query: 418 LRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQF 477
           L +    P   +   D++F+LD SA+VG  NF  ++ FV +     ++  D  +VGLV +
Sbjct: 517 LCSRQ-RPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575

Query: 478 SDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHV 537
                T F L+T  T++ +L  + Q    GG G + G+AL ++Y    T   G+  R  V
Sbjct: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTVQRGA--RPGV 632

Query: 538 PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIA 584
           P+ +++LT G+  +     A  L   GI    VG        L ++A
Sbjct: 633 PKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLA 679



 Score =  110 bits (274), Expect = 1e-23
 Identities = 94/349 (26%), Positives = 160/349 (45%), Gaps = 32/349 (9%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++FL+D S  T    F     F+   +  +     + RVGV  +S E      +  Y  
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 96  KAQVLGAVKALGFAGGELANIGLALDFVVENHF---TRAGGSRVEEGVPQVLVLISAGPS 152
              ++ ++  + F GG     G AL    E  F   TR G  R      +V+VL++   S
Sbjct: 403 VPDLVWSLDGIPFRGGPTLT-GSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457

Query: 153 SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDN--LVFTVPE--FRSFGDLQEK 208
            DE+       +   +   G+G++A  RAEL+ I       +V++ P+  F    +LQ K
Sbjct: 458 EDEVAGPARHARARELLLLGVGSEAV-RAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516

Query: 209 LLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 268
           L        QR      P   TQ +     D+VF++D S+++G  NF  ++ F+     +
Sbjct: 517 LCS-----RQR------PGCRTQAL-----DLVFMLDTSASVGPENFAQMQSFVRSCALQ 560

Query: 269 LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 328
            E+  D+ QV +  Y   V+  F  +T PT+  ++ A+    P  G     G+AL  + +
Sbjct: 561 FEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAI-SQAPYLGGVGSAGTALLHIYD 619

Query: 329 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIG 377
            + T   G  A  G+PK +V++TGG+  ++ + PAQ+L+ + I    +G
Sbjct: 620 KVMTVQRG--ARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVG 666



 Score =  100 bits (250), Expect = 7e-21
 Identities = 94/373 (25%), Positives = 168/373 (45%), Gaps = 10/373 (2%)

Query: 627 ESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
           E + D+LFL D SA   +  F   + F+ + +  +  +    R+ VA YS ++ V     
Sbjct: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398

Query: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGR 745
           E+Q  P+++  +  +  + G  L  G AL  A    F  SA    +D   + +VLL    
Sbjct: 399 EYQDVPDLVWSLDGIPFRGGPTLT-GSALRQAAERGF-GSATRTGQDRPRRVVVLLTESH 456

Query: 746 SSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIVN 805
           S D V GPA + +   ++  +     A  AELE+I  SP  ++       + +  P++  
Sbjct: 457 SEDEVAGPARHARARELL-LLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQG 515

Query: 806 LLKSVHNGAPAPVSGEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVV 864
            L S     P   +   D+VF+LD S  V    F  ++ FV+      +V  D  +V +V
Sbjct: 516 KLCSRQR--PGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLV 573

Query: 865 QYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE 924
            Y  + +  F L++   +  ++ A+ Q   LGG   + G AL  +   ++    G+R   
Sbjct: 574 VYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--P 630

Query: 925 GVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPT 984
           GVP+ ++VLT  R  +D   P+  ++  G   + +G+G      ++ ++   D  + +  
Sbjct: 631 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAA 690

Query: 985 FRQLGTVQQVISE 997
           +  L   Q V+ E
Sbjct: 691 YADLRYHQDVLIE 703



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 5/155 (3%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           DI+FLLDGS +VGK +F   + F + + + LDI  + +RVG  QFS TP  EF L+++ T
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDS 552
           + ++   ++++  +GG    T + L+  Y  H    GG      VPQ+L+++T G+S+  
Sbjct: 111 QQEVKARIKRMVFKGG---RTETELALKYLLHRGLPGGR--NASVPQILIIVTDGKSQGD 165

Query: 553 YLQAANALTRAGILTFCVGASQANKAELEQIAFNP 587
               +  L   G+  F VG       EL  +A  P
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 87/338 (25%), Positives = 150/338 (44%), Gaps = 28/338 (8%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++FLLD SA      F   + FV   V ++   +   RVG+  +S   +    +  YQ 
Sbjct: 343 DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHF---TEAGGSRIREHVPQLLLLLTAGQS 549
             D++  L  +  +GG  L TGSAL       F   T  G  R R    ++++LLT   S
Sbjct: 403 VPDLVWSLDGIPFRGGPTL-TGSALRQAAERGFGSATRTGQDRPR----RVVVLLTESHS 457

Query: 550 EDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDD----FSSLPALPQQ 605
           ED     A       +L   VG S+A +AELE+I  +P  V +  D    F+ +P L  +
Sbjct: 458 EDEVAGPARHARARELLLLGVG-SEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGK 516

Query: 606 LIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKP 664
           L             + P  + ++  D++F+ D SA++  + F  ++ F+     +  V P
Sbjct: 517 LCS----------RQRPGCRTQA-LDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNP 565

Query: 665 EGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVK 724
           + T++ +  Y   V+     D   ++  +L  + +     G   + G AL +    +   
Sbjct: 566 DVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDKVMTV 624

Query: 725 SAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGV 762
             G+R   GV + +V+L  GR ++    PA  L+ +G+
Sbjct: 625 QRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI 660



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 30/347 (8%)

Query: 823  DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
            D++FLLD S G    GF   K FV+R V ++     R RV V  YS        +  Y +
Sbjct: 343  DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 882  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVP---QLLIVLTADRS 938
              D+V ++  +   GGPT  TG+A    LR       GS    G     +++++LT   S
Sbjct: 403  VPDLVWSLDGIPFRGGPT-LTGSA----LRQAAERGFGSATRTGQDRPRRVVVLLTESHS 457

Query: 939  GDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQVISER 998
             D+V  P+   +    + +G+G   A   E++ I+               G+ + V+   
Sbjct: 458  EDEVAGPARHARARELLLLGVG-SEAVRAELEEIT---------------GSPKHVMVYS 501

Query: 999  VTQLTREELSRLQPVLQPLPSPGVGGKR-DVVFLIDGSQSAGPE-FQYVRTLIERLVDYL 1056
              Q    ++  LQ  L     PG   +  D+VF++D S S GPE F  +++ +       
Sbjct: 502  DPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQF 561

Query: 1057 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1116
            +V  D T+V ++ +    +  F L+   ++  +  A+ +    GG   + G AL ++   
Sbjct: 562  EVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVG-SAGTALLHIYDK 620

Query: 1117 IFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI 1163
            +     G+R   GVP+ +V+++ G+  ++   PA +L+  G++   +
Sbjct: 621  VMTVQRGAR--PGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVV 665



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 50/156 (32%), Positives = 83/156 (53%), Gaps = 5/156 (3%)

Query: 34  SADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTY 93
           + DI+FL+DGSN+ G  +F     F + + + L I  +++RVG  QFS  P   F LD++
Sbjct: 49  AVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSF 108

Query: 94  STKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSS 153
           ST+ +V   +K + F GG      LAL +++  H    GG      VPQ+L++++ G S 
Sbjct: 109 STQQEVKARIKRMVFKGGR-TETELALKYLL--HRGLPGGRNA--SVPQILIIVTDGKSQ 163

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 189
            ++      LK+  V  F +G +     EL  +A++
Sbjct: 164 GDVALPSKQLKERGVTVFAVGVRFPRWEELHALASE 199



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 52/144 (36%), Positives = 76/144 (52%), Gaps = 6/144 (4%)

Query: 819 SGEKDVVFLLDGSEGVRSG-FPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
           S   D++FLLDGS  V  G F   K F   V + LD+  +RVRV   Q+S     EF L+
Sbjct: 47  SAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLD 106

Query: 878 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADR 937
           S+  +Q+V   ++++   GG T  T  AL+++L   L    G R    VPQ+LI++T  +
Sbjct: 107 SFSTQQEVKARIKRMVFKGGRT-ETELALKYLLHRGL---PGGR-NASVPQILIIVTDGK 161

Query: 938 SGDDVRNPSVVVKRGGAVPIGIGI 961
           S  DV  PS  +K  G     +G+
Sbjct: 162 SQGDVALPSKQLKERGVTVFAVGV 185



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 7/155 (4%)

Query: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D++FL+DGS S G   F+  +     + D LD+  +  RV   QFS  P +EF L++ S+
Sbjct: 51   DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
            + EV+  ++R+  KGGR        E   + +  R L       VPQ L++++ GKS  +
Sbjct: 111  QQEVKARIKRMVFKGGR-----TETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165

Query: 1146 VDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179
            V  P+ +LK+ GV  F +  R    EEL  ++  P
Sbjct: 166  VALPSKQLKERGVTVFAVGVRFPRWEELHALASEP 200



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 23/184 (12%)

Query: 225 PPTIVTQVIEVNKR------------------DIVFLVDGSSALGLANFNAIRDFIAKVI 266
           PP++  Q + V+K                   DI+FL+DGS+++G  +F   + F   V 
Sbjct: 19  PPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVC 78

Query: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326
             L+I  + ++V   Q++ T   EF  ++  T++EV   +++M    G    T  AL ++
Sbjct: 79  DGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRM-VFKGGRTETELALKYL 137

Query: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386
              L     G R A  +P++L+++T GKS  +++ P+++LK   +  FA+G +     EL
Sbjct: 138 ---LHRGLPGGRNA-SVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEEL 193

Query: 387 EEIA 390
             +A
Sbjct: 194 HALA 197



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 26  QQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPR 85
           Q+      + D++F++D S + G  NFA +  F+ +   +  +     +VG+V +  + +
Sbjct: 521 QRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQ 580

Query: 86  TMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLV 145
           T F LDT  T+A +L A+    + GG + + G AL  + +   T   G+R   GVP+ +V
Sbjct: 581 TAFGLDTKPTRAAMLRAISQAPYLGG-VGSAGTALLHIYDKVMTVQRGAR--PGVPKAVV 637

Query: 146 LISAGPSSDEIR----------YGVVALKQASVFSFGLGAQAASRAELQHIA 187
           +++ G  +++              V+ +    V S GL   A  R  L H+A
Sbjct: 638 VLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVA 689



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 8/166 (4%)

Query: 631 DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
           DI+FL DGS ++  G F   + F   + D L++ PE  R+   Q+S    +E   D   +
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 690 KPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDR 749
           + E+   +KRM  K G+        + A +Y+  +         V Q L+++  G+S   
Sbjct: 111 QQEVKARIKRMVFKGGRT-----ETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165

Query: 750 VDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP--AFILAAESL 793
           V  P+  LK+ GV  F    +     EL  +   P    +L AE +
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQV 211



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 13/180 (7%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D++FL+D S     + F   +  ++R V  +       RV V  +S +  V   +  +  
Sbjct: 343  DLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQD 402

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQ---FLVLISSGKS 1142
              ++  ++  +  +GG  +  G+AL    R   +R  GS    G  +    +VL++   S
Sbjct: 403  VPDLVWSLDGIPFRGGPTLT-GSAL----RQAAERGFGSATRTGQDRPRRVVVLLTESHS 457

Query: 1143 DDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVS----TFRELPSLEQKL 1198
            +DEV  PA   +   +    +   A + EL +I+ SP++V   S     F ++P L+ KL
Sbjct: 458  EDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKL 517


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  107 bits (268), Expect = 5e-23
 Identities = 63/187 (33%), Positives = 111/187 (59%), Gaps = 5/187 (2%)

Query: 430 NKR-DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 488
           NKR D++F++D S +V   ++  V++F+++++  LDIG D  RVGL+Q+  T   EFSL 
Sbjct: 53  NKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLK 112

Query: 489 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAG 547
           T++ KS++   +++++    +G  TG A+ Y     F+EA G+R +RE+VP++++++T G
Sbjct: 113 TFKRKSEVERAVKRMR-HLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDG 171

Query: 548 QSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ 605
           + +DS  + A      GIL F +G  Q +   L+ I   P    V+L+ +FS +  L   
Sbjct: 172 RPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSV 231

Query: 606 LIQPLTT 612
             + L T
Sbjct: 232 FQKKLCT 238



 Score =  101 bits (252), Expect = 4e-21
 Identities = 57/180 (31%), Positives = 105/180 (58%), Gaps = 10/180 (5%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++F++DGS ++G+ NF  V+ FV  +++SL I     RVGL+Q+S    TEF+L  + +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 493 KSDI---LGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAGQ 548
             D+   + H++ +    G G  TG AL +++   FT+  G+R +   VP+  ++ T G+
Sbjct: 715 AKDMKKAVAHMKYM----GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 549 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM--DDFSSLPALPQQL 606
           ++D   + A+     GI  + VG  +A + EL++IA  P+  +L   +DFS++  + ++L
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 59/188 (31%), Positives = 104/188 (55%), Gaps = 5/188 (2%)

Query: 219 RHIVLKPPTIVTQVIEVNKR-DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQ 277
           RH    P T + +    NKR D+VF++D S ++   ++  +++FI  ++Q L+IG D+ +
Sbjct: 36  RHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTR 95

Query: 278 VAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGY 337
           V + QY  TV+ EF   T   K EV  AV++M+ L    + TG A+ +  N  F+ + G 
Sbjct: 96  VGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNIAFSEAEGA 154

Query: 338 R-AAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SS 394
           R   E +P++++++T G+  D +++ A + + + I+ FAIG    D   L+ I  +    
Sbjct: 155 RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHED 214

Query: 395 LVFIPAEF 402
            VF+ A F
Sbjct: 215 HVFLVANF 222



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 12/204 (5%)

Query: 800 HPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDR 858
           HPQ   L  S  N          D+VF++D S  V +  +  +KEF+  +++ LD+G D 
Sbjct: 41  HPQTALLESSCENK-------RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV 93

Query: 859 VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 918
            RV ++QY    + EF L ++  K +V  AV+++  L   T  TG A+++ L      + 
Sbjct: 94  TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGT-MTGLAIQYALNIAFSEAE 152

Query: 919 GSR-ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP- 976
           G+R + E VP++++++T  R  D V   +   +  G +   IG+G  D   +++I   P 
Sbjct: 153 GARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPH 212

Query: 977 -DFAVAIPTFRQLGTVQQVISERV 999
            D    +  F Q+ T+  V  +++
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKL 236



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 62/212 (29%), Positives = 106/212 (50%), Gaps = 10/212 (4%)

Query: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYL 1056
            R   ++R   +R  P    L S     + D+VF+ID S+S    ++  V+  I  ++ +L
Sbjct: 28   RGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFL 87

Query: 1057 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1116
            D+G D TRV ++Q+    K EF L     K EV+ AV+R+R      +  G A++Y    
Sbjct: 88   DIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNI 146

Query: 1117 IFKRPLGSR-IEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVK 1174
             F    G+R + E VP+ +++++ G+  D V + A + +  G+  F I     D   L  
Sbjct: 147  AFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKS 206

Query: 1175 ISLSP--EYVFSVSTFRELPSL----EQKLLT 1200
            I   P  ++VF V+ F ++ +L    ++KL T
Sbjct: 207  IGSEPHEDHVFLVANFSQIETLTSVFQKKLCT 238



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 50/185 (27%), Positives = 98/185 (52%), Gaps = 4/185 (2%)

Query: 28  QQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTM 87
           ++  +   D++F+IDGS + G  NF V+  F+  +++ L I  +  RVG++Q+S +  T 
Sbjct: 647 KKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTE 706

Query: 88  FSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSR-VEEGVPQVLVL 146
           F+L  +++   +  AV  + +  G+ +  GLAL  + E  FT+  G+R +   VP+  ++
Sbjct: 707 FTLRNFNSAKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIV 765

Query: 147 ISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGD 204
            + G + D++       K   +  + +G   A   ELQ IA++  +  +F   +F +  +
Sbjct: 766 FTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDE 825

Query: 205 LQEKL 209
           + EKL
Sbjct: 826 ISEKL 830



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 49/153 (32%), Positives = 82/153 (53%), Gaps = 2/153 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++DGS +LG  NF  ++ F+  +I  L I     +V + QY+  V  EF      +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
            +++  AV  MK + G    TG AL  +    FT   G R  +  +P+  ++ T G++ D
Sbjct: 715 AKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           ++S+ A + K + I  +A+G   A + EL+EIA
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 50/183 (27%), Positives = 95/183 (51%), Gaps = 6/183 (3%)

Query: 21  PTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQF 80
           P T   +       AD++F+ID S +  + ++A + +F+V++L+ L IG    RVG++Q+
Sbjct: 42  PQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQY 101

Query: 81  SDEPRTMFSLDTYSTKAQVLGAVKAL-GFAGGELANIGLALDFVVENHFTRAGGSR-VEE 138
               +  FSL T+  K++V  AVK +   + G +   GLA+ + +   F+ A G+R + E
Sbjct: 102 GSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMT--GLAIQYALNIAFSEAEGARPLRE 159

Query: 139 GVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTV 196
            VP+V+++++ G   D +       +   +  F +G        L+ I ++  ++ VF V
Sbjct: 160 NVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLV 219

Query: 197 PEF 199
             F
Sbjct: 220 ANF 222



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 49/159 (30%), Positives = 84/159 (52%), Gaps = 3/159 (1%)

Query: 820 GEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 878
           G  D+VF++DGS+ +    F ++K+FV  +++SL +     RV ++QYS +   EF L +
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 879 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTADR 937
           + + +D+  AV  +  +G  +  TG AL+ +         G+R ++  VP+  IV T  R
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGS-MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 938 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
           + DDV   +   K  G     +G+G A   E+Q I+  P
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 50/180 (27%), Positives = 96/180 (53%), Gaps = 6/180 (3%)

Query: 1024 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+VF+IDGS+S G E F+ V+  +  ++D L +     RV ++Q+S     EF L  
Sbjct: 652  GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 1141
             +S  +++ AV  ++  G   +  G AL+++    F +  G+R +   VP+  ++ + G+
Sbjct: 712  FNSAKDMKKAVAHMKYMGKGSM-TGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 1198
            + D+V + A + K  G+  + +    A +EEL +I+  P  +++F    F  +  + +KL
Sbjct: 771  AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 48/160 (30%), Positives = 74/160 (46%), Gaps = 3/160 (1%)

Query: 627 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
           E   D++F+ DGS +L  + F VV+ F+  IID L + P+  R+ + QYS  V  E    
Sbjct: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710

Query: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAG 744
              S  ++   V  MK   GK    G AL +     F +  G+R +   V +  ++   G
Sbjct: 711 NFNSAKDMKKAVAHMKY-MGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDG 769

Query: 745 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
           R+ D V   AS  K +G+  +      A   EL++I   P
Sbjct: 770 RAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 6/162 (3%)

Query: 627 ESKR-DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRF 684
           E+KR D++F+ D S ++    +  V++F+  I+  L++ P+ TR+ + QY   VK E   
Sbjct: 52  ENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSL 111

Query: 685 DEHQSKPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLV 742
              + K E+   VKRM+ + TG     G A+ YA    F ++ G+R + + V + ++++ 
Sbjct: 112 KTFKRKSEVERAVKRMRHLSTGTM--TGLAIQYALNIAFSEAEGARPLRENVPRVIMIVT 169

Query: 743 AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
            GR  D V   A+  + +G++ F       D   L+ I   P
Sbjct: 170 DGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEP 211


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  107 bits (268), Expect = 5e-23
 Identities = 63/187 (33%), Positives = 111/187 (59%), Gaps = 5/187 (2%)

Query: 430 NKR-DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLN 488
           NKR D++F++D S +V   ++  V++F+++++  LDIG D  RVGL+Q+  T   EFSL 
Sbjct: 53  NKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLK 112

Query: 489 TYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAG 547
           T++ KS++   +++++    +G  TG A+ Y     F+EA G+R +RE+VP++++++T G
Sbjct: 113 TFKRKSEVERAVKRMR-HLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDG 171

Query: 548 QSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP--SLVYLMDDFSSLPALPQQ 605
           + +DS  + A      GIL F +G  Q +   L+ I   P    V+L+ +FS +  L   
Sbjct: 172 RPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSV 231

Query: 606 LIQPLTT 612
             + L T
Sbjct: 232 FQKKLCT 238



 Score =  101 bits (252), Expect = 4e-21
 Identities = 57/180 (31%), Positives = 105/180 (58%), Gaps = 10/180 (5%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++F++DGS ++G+ NF  V+ FV  +++SL I     RVGL+Q+S    TEF+L  + +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 493 KSDI---LGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSR-IREHVPQLLLLLTAGQ 548
             D+   + H++ +    G G  TG AL +++   FT+  G+R +   VP+  ++ T G+
Sbjct: 715 AKDMKKAVAHMKYM----GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 549 SEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLM--DDFSSLPALPQQL 606
           ++D   + A+     GI  + VG  +A + EL++IA  P+  +L   +DFS++  + ++L
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 59/188 (31%), Positives = 104/188 (55%), Gaps = 5/188 (2%)

Query: 219 RHIVLKPPTIVTQVIEVNKR-DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQ 277
           RH    P T + +    NKR D+VF++D S ++   ++  +++FI  ++Q L+IG D+ +
Sbjct: 36  RHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTR 95

Query: 278 VAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGY 337
           V + QY  TV+ EF   T   K EV  AV++M+ L    + TG A+ +  N  F+ + G 
Sbjct: 96  VGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNIAFSEAEGA 154

Query: 338 R-AAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD--SS 394
           R   E +P++++++T G+  D +++ A + + + I+ FAIG    D   L+ I  +    
Sbjct: 155 RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHED 214

Query: 395 LVFIPAEF 402
            VF+ A F
Sbjct: 215 HVFLVANF 222



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 12/204 (5%)

Query: 800 HPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDR 858
           HPQ   L  S  N          D+VF++D S  V +  +  +KEF+  +++ LD+G D 
Sbjct: 41  HPQTALLESSCENK-------RADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV 93

Query: 859 VRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSA 918
            RV ++QY    + EF L ++  K +V  AV+++  L   T  TG A+++ L      + 
Sbjct: 94  TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGT-MTGLAIQYALNIAFSEAE 152

Query: 919 GSR-ITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP- 976
           G+R + E VP++++++T  R  D V   +   +  G +   IG+G  D   +++I   P 
Sbjct: 153 GARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPH 212

Query: 977 -DFAVAIPTFRQLGTVQQVISERV 999
            D    +  F Q+ T+  V  +++
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKL 236



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 62/212 (29%), Positives = 106/212 (50%), Gaps = 10/212 (4%)

Query: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYL 1056
            R   ++R   +R  P    L S     + D+VF+ID S+S    ++  V+  I  ++ +L
Sbjct: 28   RGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFL 87

Query: 1057 DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRN 1116
            D+G D TRV ++Q+    K EF L     K EV+ AV+R+R      +  G A++Y    
Sbjct: 88   DIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTM-TGLAIQYALNI 146

Query: 1117 IFKRPLGSR-IEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTI-ARNADQEELVK 1174
             F    G+R + E VP+ +++++ G+  D V + A + +  G+  F I     D   L  
Sbjct: 147  AFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKS 206

Query: 1175 ISLSP--EYVFSVSTFRELPSL----EQKLLT 1200
            I   P  ++VF V+ F ++ +L    ++KL T
Sbjct: 207  IGSEPHEDHVFLVANFSQIETLTSVFQKKLCT 238



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 50/185 (27%), Positives = 98/185 (52%), Gaps = 4/185 (2%)

Query: 28  QQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTM 87
           ++  +   D++F+IDGS + G  NF V+  F+  +++ L I  +  RVG++Q+S +  T 
Sbjct: 647 KKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTE 706

Query: 88  FSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSR-VEEGVPQVLVL 146
           F+L  +++   +  AV  + +  G+ +  GLAL  + E  FT+  G+R +   VP+  ++
Sbjct: 707 FTLRNFNSAKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIV 765

Query: 147 ISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGD 204
            + G + D++       K   +  + +G   A   ELQ IA++  +  +F   +F +  +
Sbjct: 766 FTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDE 825

Query: 205 LQEKL 209
           + EKL
Sbjct: 826 ISEKL 830



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 49/153 (32%), Positives = 82/153 (53%), Gaps = 2/153 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++DGS +LG  NF  ++ F+  +I  L I     +V + QY+  V  EF      +
Sbjct: 655 DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNS 714

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
            +++  AV  MK + G    TG AL  +    FT   G R  +  +P+  ++ T G++ D
Sbjct: 715 AKDMKKAVAHMKYM-GKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQD 773

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           ++S+ A + K + I  +A+G   A + EL+EIA
Sbjct: 774 DVSEWASKAKANGITMYAVGVGKAIEEELQEIA 806



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 50/183 (27%), Positives = 95/183 (51%), Gaps = 6/183 (3%)

Query: 21  PTTHAQQQQAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQF 80
           P T   +       AD++F+ID S +  + ++A + +F+V++L+ L IG    RVG++Q+
Sbjct: 42  PQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQY 101

Query: 81  SDEPRTMFSLDTYSTKAQVLGAVKAL-GFAGGELANIGLALDFVVENHFTRAGGSR-VEE 138
               +  FSL T+  K++V  AVK +   + G +   GLA+ + +   F+ A G+R + E
Sbjct: 102 GSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMT--GLAIQYALNIAFSEAEGARPLRE 159

Query: 139 GVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTV 196
            VP+V+++++ G   D +       +   +  F +G        L+ I ++  ++ VF V
Sbjct: 160 NVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLV 219

Query: 197 PEF 199
             F
Sbjct: 220 ANF 222



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 49/159 (30%), Positives = 84/159 (52%), Gaps = 3/159 (1%)

Query: 820 GEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 878
           G  D+VF++DGS+ +    F ++K+FV  +++SL +     RV ++QYS +   EF L +
Sbjct: 652 GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 879 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTADR 937
           + + +D+  AV  +  +G  +  TG AL+ +         G+R ++  VP+  IV T  R
Sbjct: 712 FNSAKDMKKAVAHMKYMGKGS-MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 938 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
           + DDV   +   K  G     +G+G A   E+Q I+  P
Sbjct: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 50/180 (27%), Positives = 96/180 (53%), Gaps = 6/180 (3%)

Query: 1024 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+VF+IDGS+S G E F+ V+  +  ++D L +     RV ++Q+S     EF L  
Sbjct: 652  GPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRN 711

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 1141
             +S  +++ AV  ++  G   +  G AL+++    F +  G+R +   VP+  ++ + G+
Sbjct: 712  FNSAKDMKKAVAHMKYMGKGSM-TGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQKL 1198
            + D+V + A + K  G+  + +    A +EEL +I+  P  +++F    F  +  + +KL
Sbjct: 771  AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 48/160 (30%), Positives = 74/160 (46%), Gaps = 3/160 (1%)

Query: 627 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
           E   D++F+ DGS +L  + F VV+ F+  IID L + P+  R+ + QYS  V  E    
Sbjct: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710

Query: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAG 744
              S  ++   V  MK   GK    G AL +     F +  G+R +   V +  ++   G
Sbjct: 711 NFNSAKDMKKAVAHMKY-MGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDG 769

Query: 745 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
           R+ D V   AS  K +G+  +      A   EL++I   P
Sbjct: 770 RAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEP 809



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 6/162 (3%)

Query: 627 ESKR-DILFLFDGSANL-VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRF 684
           E+KR D++F+ D S ++    +  V++F+  I+  L++ P+ TR+ + QY   VK E   
Sbjct: 52  ENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSL 111

Query: 685 DEHQSKPEILNLVKRMK-IKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLV 742
              + K E+   VKRM+ + TG     G A+ YA    F ++ G+R + + V + ++++ 
Sbjct: 112 KTFKRKSEVERAVKRMRHLSTGTM--TGLAIQYALNIAFSEAEGARPLRENVPRVIMIVT 169

Query: 743 AGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
            GR  D V   A+  + +G++ F       D   L+ I   P
Sbjct: 170 DGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEP 211


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 66/198 (33%), Positives = 107/198 (54%), Gaps = 12/198 (6%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD--IGNDNIRVGLVQFSDTPVTEFSLNTY 490
           DI+FLLDGS+++G++NF  VR F+  LV           +R   VQ+SD P TEF L+  
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 491 QTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSE 550
            +  D++  +R+L  +GG+   TG+A+ +V  + F        R  VP++ +L+T G+S+
Sbjct: 98  GSGGDVIRAIRELSYKGGN-TRTGAAILHVADHVFLP---QLARPGVPKVCILITDGKSQ 153

Query: 551 DSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPS--LVYLMDDFSSLPALPQQLIQ 608
           D    AA  L   G+  F VG   A+  EL+++A  P+    + ++DFS L  L   + +
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 609 PLTTYVSGGVEEVPLAQP 626
            + T   G    VP+ +P
Sbjct: 214 RVCTTAGG----VPVTRP 227



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 67/174 (38%), Positives = 96/174 (55%), Gaps = 10/174 (5%)

Query: 1027 DVVFLIDGSQSAG-PEFQYVRTLIERLVDYLD--VGFDTTRVAVIQFSDDPKVEFLLNAH 1083
            D+VFL+DGS S G   F+ VR+ +E LV            R A +Q+SDDP+ EF L+A 
Sbjct: 38   DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 1084 SSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSD 1143
             S  +V  A++ L  KGG     G A+ +V+ ++F   L      GVP+  +LI+ GKS 
Sbjct: 98   GSGGDVIRAIRELSYKGG-NTRTGAAILHVADHVF---LPQLARPGVPKVCILITDGKSQ 153

Query: 1144 DEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSP--EYVFSVSTFRELPSL 1194
            D VD  A  LK  GV  F +  +NAD EEL +++  P  ++ F V+ F  L +L
Sbjct: 154  DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTL 207



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 55/154 (35%), Positives = 86/154 (55%), Gaps = 6/154 (3%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDL--IQVAVAQYADTVRPEFYFNTH 296
           DIVFL+DGSS++G +NF  +R F+  ++           ++ A  QY+D  R EF  +  
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356
            +  +VI A+R++    G+   TG+A+  V +++F       A  G+PK+ +LIT GKS 
Sbjct: 98  GSGGDVIRAIRELSYKGGNTR-TGAAILHVADHVFLPQL---ARPGVPKVCILITDGKSQ 153

Query: 357 DEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           D +   AQ LK   +  FA+G K AD  EL+ +A
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVA 187



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 77/253 (30%), Positives = 114/253 (45%), Gaps = 21/253 (8%)

Query: 9   LVAVFCL-FLSGFPTTHAQQQQAAQDS----ADIIFLIDGSNNTGSVNFAVILDFLVNLL 63
           LVA  C   L+  P   AQ ++    +    ADI+FL+DGS++ G  NF  +  FL  L+
Sbjct: 6   LVAALCAGILAEAPRVRAQHRERVTCTRLYAADIVFLLDGSSSIGRSNFREVRSFLEGLV 65

Query: 64  EKLPIG----TQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLA 119
             LP       Q +R   VQ+SD+PRT F LD   +   V+ A++ L + GG     G A
Sbjct: 66  --LPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGDVIRAIRELSYKGGN-TRTGAA 122

Query: 120 LDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAAS 179
           +  V ++ F          GVP+V +LI+ G S D +      LK   V  F +G + A 
Sbjct: 123 ILHVADHVFL---PQLARPGVPKVCILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNAD 179

Query: 180 RAELQHIATD--DNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNK 237
             EL+ +A+    +  F V +F     L   +   +   A    V +PP   T       
Sbjct: 180 PEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRVCTTAGGVPVTRPPDDSTSA----P 235

Query: 238 RDIVFLVDGSSAL 250
           RD+V     S +L
Sbjct: 236 RDLVLSEPSSQSL 248



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 109/220 (49%), Gaps = 15/220 (6%)

Query: 823  DVVFLLDGSEGV-RSGFPLLKEFVQRVVESLD--VGQDRVRVAVVQYSDRTRPEFYLNSY 879
            D+VFLLDGS  + RS F  ++ F++ +V           VR A VQYSD  R EF L++ 
Sbjct: 38   DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 880  MNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSG 939
             +  DV+ A+R+L+  GG T  TGAA+  V  ++ +         GVP++ I++T  +S 
Sbjct: 98   GSGGDVIRAIRELSYKGGNT-RTGAAILHVADHVFLPQLA---RPGVPKVCILITDGKSQ 153

Query: 940  DDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP--DFAVAIPTFRQLGTVQQVISE 997
            D V   +  +K  G     +GI NAD  E++ ++  P  DF   +  F  L T+  ++S 
Sbjct: 154  DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 998  RVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQS 1037
            RV            PV +P P       RD+V     SQS
Sbjct: 214  RVCTTAGG-----VPVTRP-PDDSTSAPRDLVLSEPSSQS 247



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 60/216 (27%), Positives = 95/216 (43%), Gaps = 15/216 (6%)

Query: 631 DILFLFDGSANLV-GQFPVVRDFLYKIIDELN--VKPEGTRIAVAQYSDDVKVESRFDEH 687
           DI+FL DGS+++    F  VR FL  ++   +     +G R A  QYSDD + E   D  
Sbjct: 38  DIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDAL 97

Query: 688 QSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSS 747
            S  +++  ++ +  K G     G A+ +   ++F+         GV +  +L+  G+S 
Sbjct: 98  GSGGDVIRAIRELSYKGGNT-RTGAAILHVADHVFLPQLA---RPGVPKVCILITDGKSQ 153

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA--FILAAESLPKIGDLHPQIVN 805
           D VD  A  LK  GV  F    KNADP EL+++   P   F         +  L P +  
Sbjct: 154 DLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSR 213

Query: 806 LLKSVHNGAPA------PVSGEKDVVFLLDGSEGVR 835
            + +   G P         S  +D+V     S+ +R
Sbjct: 214 RVCTTAGGVPVTRPPDDSTSAPRDLVLSEPSSQSLR 249



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 3/205 (1%)

Query: 815  PAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLD-VGQDRVRVAVVQYSDRTRPE 873
            P    G  DVVFL   ++         +  ++R+V +L  +G   V+V ++ YS R  P 
Sbjct: 1046 PVCPRGLADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPL 1105

Query: 874  FYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVL 933
            F LN   +   ++  +R +  +     N G A+    R +L   A  R  + VP ++++L
Sbjct: 1106 FPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGR-RQHVPGVMVLL 1164

Query: 934  TADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQ 993
              +    D+ +P    +  G   + +G+  AD  +++ ++   D            ++ Q
Sbjct: 1165 VDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQ 1224

Query: 994  VISERVTQLTREELSRLQPVLQPLP 1018
             +S   T L +   +  QP  +P P
Sbjct: 1225 AVSGLATALCQASFT-TQPRPEPCP 1248



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 58/229 (25%), Positives = 94/229 (41%), Gaps = 26/229 (11%)

Query: 996  SERVTQLTR--EELSRLQPVLQPLPSPGVG---------GKRDVVFLIDGSQSAGPEFQY 1044
            S+RVT L      +  L PVL  +  P            G  DVVFL   +Q      + 
Sbjct: 1012 SQRVTGLEPGVSYIFSLTPVLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEA 1071

Query: 1045 VRTLIERLVDYL-DVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQRLR------ 1097
             R ++ERLV  L  +G    +V ++ +S  P   F LN      ++   +QR+R      
Sbjct: 1072 TRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPLFPLN---GSHDLGIILQRIRDMPYMD 1128

Query: 1098 PKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFG 1157
            P G    N+G A+    R +       R  + VP  +VL+       ++  P  E +  G
Sbjct: 1129 PSGN---NLGTAVVTAHRYMLAPDAPGR-RQHVPGVMVLLVDEPLRGDIFSPIREAQASG 1184

Query: 1158 VAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTL 1205
            +    +    AD E+L +++   + V +     + PSL+Q +    T L
Sbjct: 1185 LNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQAVSGLATAL 1233



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 5/155 (3%)

Query: 35   ADIIFLIDGSNNTGSVNFAV--ILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 92
            AD++FL   + +      A   +L+ LV  L   P+G Q ++VG++ +S  P  +F L+ 
Sbjct: 1053 ADVVFLPHATQDNAHRAEATRRVLERLVLALG--PLGPQAVQVGLLSYSHRPSPLFPLNG 1110

Query: 93   YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 152
                  +L  ++ + +      N+G A+      +          + VP V+VL+   P 
Sbjct: 1111 SHDLGIILQRIRDMPYMDPSGNNLGTAV-VTAHRYMLAPDAPGRRQHVPGVMVLLVDEPL 1169

Query: 153  SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIA 187
              +I   +   + + +    LG   A   +L+ +A
Sbjct: 1170 RGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLA 1204



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 36/164 (21%), Positives = 64/164 (39%), Gaps = 3/164 (1%)

Query: 618  VEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELN-VKPEGTRIAVAQYSD 676
            V + P+  P    D++FL   + +   +    R  L +++  L  + P+  ++ +  YS 
Sbjct: 1042 VTQTPVC-PRGLADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSH 1100

Query: 677  DVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQ 736
                    +       IL  ++ M        NLG A+  A RY+    A  R    V  
Sbjct: 1101 RPSPLFPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGR-RQHVPG 1159

Query: 737  FLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQI 780
             +VLLV       +  P    + SG+   +     ADP +L ++
Sbjct: 1160 VMVLLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRL 1203


>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
          Length = 540

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 62/177 (35%), Positives = 100/177 (56%), Gaps = 4/177 (2%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++ L+DGS +V   NF  V+ FV  +V+ LD+  +  RVGLVQFS    TEF L  Y T
Sbjct: 304 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 363

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 551
            +++   +  ++     G  TG AL ++  + F+EA G+R R  +VP++ L+ T G+S+D
Sbjct: 364 AAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 422

Query: 552 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQL 606
                A      GI+ + VG  +A +AEL +IA  P+ +++    DF ++  L + L
Sbjct: 423 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 479



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 59/178 (33%), Positives = 95/178 (53%), Gaps = 6/178 (3%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++ L+DGS +    NF ++  F+  +++ L +  +  RVG+VQFS   RT F L  Y T
Sbjct: 304 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 363

Query: 96  KAQVLGAVKALGF-AGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 153
            A+V  AV A+ +   G +   GLAL  +VE+ F+ A G+R     VP+V ++ + G S 
Sbjct: 364 AAEVKQAVLAVEYMERGTMT--GLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQ 421

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKL 209
           D+I       K+  +  + +G   A  AEL+ IA++  +  V   P+F +   L E L
Sbjct: 422 DDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 479



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 8/189 (4%)

Query: 414 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 470
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 471 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 530
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 531 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 587
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 588 SLVYLMDDF 596
             V+L++ F
Sbjct: 191 EHVFLVESF 199



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 59/170 (34%), Positives = 87/170 (51%), Gaps = 12/170 (7%)

Query: 820 GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 878
           G  D+V L+DGS+ VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  
Sbjct: 301 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 360

Query: 879 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADR 937
           Y    +V  AV  +  +   T  TG AL  ++ +    + G+R     VP++ +V T  R
Sbjct: 361 YGTAAEVKQAVLAVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 419

Query: 938 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTI---------SFIPDF 978
           S DD+   +   K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 420 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 469



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 59/184 (32%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+V LVDGS ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T
Sbjct: 304 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 363

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
             EV  AV  ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D
Sbjct: 364 AAEVKQAVLAVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 422

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLL 415
           +IS  A   K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL
Sbjct: 423 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLL 476

Query: 416 APLR 419
             LR
Sbjct: 477 ENLR 480



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 1024 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31   GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 1141
             S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91   FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 1188
              D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150  PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 2/153 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++D S ++    F  +R F+  +++ L +G +  +V V QY+  V+  F       
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
           + ++  A+R + PL      TG A+ +  N  F+ + G R   E +P++ V++T G+  D
Sbjct: 94  REDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
            +++ A + +   I  +A+G + AD   L  +A
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMA 185



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 50/168 (29%), Positives = 86/168 (51%), Gaps = 6/168 (3%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F+ID S +     F  +  FL+ LL  L +G    RVGV+Q+S + +++F L  +S 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 96  KAQVLGAVKAL-GFAGGELANIGLALDFVVENHFTRAGGSR-VEEGVPQVLVLISAGPSS 153
           +  +  A++ L   A G +   GLA+ + +   F+ A G+R  EE VP+V V+++ G   
Sbjct: 94  REDMERAIRDLVPLAQGTMT--GLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEF 199
           D +       +   +  + +G Q A    L+ +A+   D  VF V  F
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 44/160 (27%), Positives = 85/160 (53%), Gaps = 3/160 (1%)

Query: 819 SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
           +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30  TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 878 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 936
           ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90  AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 937 RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
           R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 149 RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 4/159 (2%)

Query: 1024 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+V L+DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  
Sbjct: 301  GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 360

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGK 1141
            + +  EV+ AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+
Sbjct: 361  YGTAAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 419

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179
            S D++   A   K+ G+  + +    A + EL +I+  P
Sbjct: 420  SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEP 458



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 4/186 (2%)

Query: 627 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
           E   D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  V+ E    
Sbjct: 300 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 359

Query: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAG 744
            + +  E+   V  ++    +    G AL +   + F ++ G+R     V +  ++   G
Sbjct: 360 RYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDG 418

Query: 745 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIV 804
           RS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  G +   + 
Sbjct: 419 RSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDFGTMTHLLE 477

Query: 805 NLLKSV 810
           NL  S+
Sbjct: 478 NLRGSI 483



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 45/157 (28%), Positives = 74/157 (47%), Gaps = 5/157 (3%)

Query: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 688
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 689 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 747
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
           DRV   A+  +  G+  +    + AD   L  +   P
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188


>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
          Length = 581

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 62/177 (35%), Positives = 100/177 (56%), Gaps = 4/177 (2%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQT 492
           D++ L+DGS +V   NF  V+ FV  +V+ LD+  +  RVGLVQFS    TEF L  Y T
Sbjct: 345 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 404

Query: 493 KSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIRE-HVPQLLLLLTAGQSED 551
            +++   +  ++     G  TG AL ++  + F+EA G+R R  +VP++ L+ T G+S+D
Sbjct: 405 AAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 463

Query: 552 SYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL--MDDFSSLPALPQQL 606
                A      GI+ + VG  +A +AEL +IA  P+ +++    DF ++  L + L
Sbjct: 464 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 520



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 59/178 (33%), Positives = 95/178 (53%), Gaps = 6/178 (3%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++ L+DGS +    NF ++  F+  +++ L +  +  RVG+VQFS   RT F L  Y T
Sbjct: 345 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 404

Query: 96  KAQVLGAVKALGF-AGGELANIGLALDFVVENHFTRAGGSRVEE-GVPQVLVLISAGPSS 153
            A+V  AV A+ +   G +   GLAL  +VE+ F+ A G+R     VP+V ++ + G S 
Sbjct: 405 AAEVKQAVLAVEYMERGTMT--GLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQ 462

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEFRSFGDLQEKL 209
           D+I       K+  +  + +G   A  AEL+ IA++  +  V   P+F +   L E L
Sbjct: 463 DDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 520



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 8/189 (4%)

Query: 414 LLAPLRT---LSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNI 470
           LL P  T   L+G P  H+   D++F++D S +V    F  +R F+M L+  L++G +  
Sbjct: 13  LLQPWETQLQLTG-PRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNAT 71

Query: 471 RVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGG 530
           RVG++Q+S    + F L  +  + D+   +R L +    G  TG A+ Y     F+ A G
Sbjct: 72  RVGVIQYSSQVQSVFPLRAFSRREDMERAIRDL-VPLAQGTMTGLAIQYAMNVAFSVAEG 130

Query: 531 SR-IREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNP-- 587
           +R   E VP++ +++T G+ +D   + A      GI  + VG  +A+   L  +A  P  
Sbjct: 131 ARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLD 190

Query: 588 SLVYLMDDF 596
             V+L++ F
Sbjct: 191 EHVFLVESF 199



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 59/170 (34%), Positives = 87/170 (51%), Gaps = 12/170 (7%)

Query: 820 GEKDVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNS 878
           G  D+V L+DGS+ VR   F L+K FV ++V+ LDV  +  RV +VQ+S R R EF L  
Sbjct: 342 GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 401

Query: 879 YMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITE-GVPQLLIVLTADR 937
           Y    +V  AV  +  +   T  TG AL  ++ +    + G+R     VP++ +V T  R
Sbjct: 402 YGTAAEVKQAVLAVEYMERGT-MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 460

Query: 938 SGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTI---------SFIPDF 978
           S DD+   +   K  G V   +G+G A   E++ I         S+ PDF
Sbjct: 461 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDF 510



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 59/184 (32%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+V LVDGS ++   NF  ++ F+ +++  L++  +  +V + Q++  VR EF    + T
Sbjct: 345 DLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGT 404

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
             EV  AV  ++ ++   + TG AL  +  + F+ + G R  A  +P++ ++ T G+S D
Sbjct: 405 AAEVKQAVLAVEYMERGTM-TGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQD 463

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRA--APLQGMLPGLL 415
           +IS  A   K   I+ +A+G   A +AEL EIA +      PAE     AP  G +  LL
Sbjct: 464 DISVWAARAKEEGIVMYAVGVGKAVEAELREIASE------PAELHVSYAPDFGTMTHLL 517

Query: 416 APLR 419
             LR
Sbjct: 518 ENLR 521



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%)

Query: 1024 GKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+VF+ID S+S  P EF+ +R  +  L+  L+VG + TRV VIQ+S   +  F L A
Sbjct: 31   GPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRA 90

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGK 1141
             S +++++ A++ L P   +    G A++Y     F    G+R  EE VP+  V+++ G+
Sbjct: 91   FSRREDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGR 149

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTF 1188
              D V + A + +  G+  + +  + AD   L  ++  P  E+VF V +F
Sbjct: 150  PQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 2/153 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++D S ++    F  +R F+  +++ L +G +  +V V QY+  V+  F       
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
           + ++  A+R + PL      TG A+ +  N  F+ + G R   E +P++ V++T G+  D
Sbjct: 94  REDMERAIRDLVPL-AQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQD 152

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
            +++ A + +   I  +A+G + AD   L  +A
Sbjct: 153 RVAEVAAQARARGIEIYAVGVQRADVGSLRAMA 185



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 50/168 (29%), Positives = 86/168 (51%), Gaps = 6/168 (3%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F+ID S +     F  +  FL+ LL  L +G    RVGV+Q+S + +++F L  +S 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 96  KAQVLGAVKAL-GFAGGELANIGLALDFVVENHFTRAGGSR-VEEGVPQVLVLISAGPSS 153
           +  +  A++ L   A G +   GLA+ + +   F+ A G+R  EE VP+V V+++ G   
Sbjct: 94  REDMERAIRDLVPLAQGTMT--GLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD--DNLVFTVPEF 199
           D +       +   +  + +G Q A    L+ +A+   D  VF V  F
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 44/160 (27%), Positives = 85/160 (53%), Gaps = 3/160 (1%)

Query: 819 SGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLN 877
           +G  D+VF++D S  VR   F  +++F+  ++  L+VG +  RV V+QYS + +  F L 
Sbjct: 30  TGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLR 89

Query: 878 SYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLLIVLTAD 936
           ++  ++D+  A+R L  L   T  TG A+++ +      + G+R   E VP++ +++T  
Sbjct: 90  AFSRREDMERAIRDLVPLAQGT-MTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDG 148

Query: 937 RSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
           R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 149 RPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 4/159 (2%)

Query: 1024 GKRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082
            G  D+V L+DGS+S  P+ F+ V+  + ++VD+LDV  + TRV ++QFS   + EF L  
Sbjct: 342  GHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGR 401

Query: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEE-GVPQFLVLISSGK 1141
            + +  EV+ AV  +     R    G AL ++  + F    G+R     VP+  ++ + G+
Sbjct: 402  YGTAAEVKQAVLAVEYM-ERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 460

Query: 1142 SDDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP 1179
            S D++   A   K+ G+  + +    A + EL +I+  P
Sbjct: 461  SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEP 499



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 4/186 (2%)

Query: 627 ESKRDILFLFDGSANLVGQ-FPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFD 685
           E   D++ L DGS ++  Q F +V+ F+ +I+D L+V PEGTR+ + Q+S  V+ E    
Sbjct: 341 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 400

Query: 686 EHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIED-GVLQFLVLLVAG 744
            + +  E+   V  ++    +    G AL +   + F ++ G+R     V +  ++   G
Sbjct: 401 RYGTAAEVKQAVLAVEYME-RGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDG 459

Query: 745 RSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPKIGDLHPQIV 804
           RS D +   A+  K+ G+V +      A  AEL +I   PA  L     P  G +   + 
Sbjct: 460 RSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPA-ELHVSYAPDFGTMTHLLE 518

Query: 805 NLLKSV 810
           NL  S+
Sbjct: 519 NLRGSI 524



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 45/157 (28%), Positives = 74/157 (47%), Gaps = 5/157 (3%)

Query: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQ- 688
           D++F+ D S ++   +F  +R FL  ++  LNV P  TR+ V QYS   +V+S F     
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSS--QVQSVFPLRAF 91

Query: 689 SKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 747
           S+ E +    R  +   +    G A+ YA    F  + G+R  E+ V +  V++  GR  
Sbjct: 92  SRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQ 151

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
           DRV   A+  +  G+  +    + AD   L  +   P
Sbjct: 152 DRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPP 188


>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
          Length = 957

 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 63/204 (30%), Positives = 107/204 (52%), Gaps = 13/204 (6%)

Query: 414 LLAPLRTLSGTPEVHSNKR----DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDN 469
           LL     L+   EV S+ R    D++F+LDGS +VG  NF  V+ +++N+  + DIG   
Sbjct: 14  LLLQNSVLAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKF 73

Query: 470 IRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAG 529
           I+VG+VQ+SD PV E  L +Y +   +   +  +   GG+   TG A+ +     F ++ 
Sbjct: 74  IQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGN-TKTGKAIQFALDYLFAKSS 132

Query: 530 GSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVG-ASQANKAELEQIAFNPS 588
                  + ++ ++LT G+S+D    AA A   + I  F +G  S+   AEL  IA  PS
Sbjct: 133 -----RFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPS 187

Query: 589 LVYL--MDDFSSLPALPQQLIQPL 610
             Y+  ++D+ ++  + + + Q L
Sbjct: 188 STYVFYVEDYIAISKIREVMKQKL 211



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 51/161 (31%), Positives = 84/161 (52%), Gaps = 7/161 (4%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++DGS ++G  NF  ++ ++  + +  +IG   IQV V QY+D    E    ++ +
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
              +  AV  +  L G+   TG A+ F  + LF  S+ +     + K+ V++T GKS D+
Sbjct: 97  GEHLTAAVESILYLGGNT-KTGKAIQFALDYLFAKSSRF-----LTKIAVVLTDGKSQDD 150

Query: 359 ISQPAQELKRSSIMAFAIG-NKGADQAELEEIAFDSSLVFI 398
           +   AQ  + S I  FAIG     + AEL  IA   S  ++
Sbjct: 151 VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYV 191



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 49/176 (27%), Positives = 96/176 (54%), Gaps = 11/176 (6%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F++DGS + G  NF ++  +LVN+ +   IG + I+VGVVQ+SD P     L +Y +
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 96  KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDE 155
              +  AV+++ + GG     G A+ F ++  F ++        + ++ V+++ G S D+
Sbjct: 97  GEHLTAAVESILYLGGN-TKTGKAIQFALDYLFAKS-----SRFLTKIAVVLTDGKSQDD 150

Query: 156 IRYGVVALKQASV--FSFGLGAQAASRAELQHIAT--DDNLVFTVPEFRSFGDLQE 207
           ++    A + + +  F+ G+G++    AEL+ IA       VF V ++ +   ++E
Sbjct: 151 VKDAAQAARDSKITLFAIGVGSETED-AELRAIANKPSSTYVFYVEDYIAISKIRE 205



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 49/183 (26%), Positives = 97/183 (53%), Gaps = 10/183 (5%)

Query: 823  DVVFLLDGSEGVR-SGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMN 881
            D+VF+LDGS  V    F ++K+++  + ++ D+G   ++V VVQYSD    E  L SY +
Sbjct: 37   DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 882  KQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDD 941
             + +  AV  +  LGG T  TG A++F L  +   S     +  + ++ +VLT  +S DD
Sbjct: 97   GEHLTAAVESILYLGGNT-KTGKAIQFALDYLFAKS-----SRFLTKIAVVLTDGKSQDD 150

Query: 942  VRNPSVVVKRGGAVPIGIGIGN-ADITEMQTISFIPD--FAVAIPTFRQLGTVQQVISER 998
            V++ +   +        IG+G+  +  E++ I+  P   +   +  +  +  +++V+ ++
Sbjct: 151  VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQK 210

Query: 999  VTQ 1001
            + +
Sbjct: 211  LCE 213



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 51/175 (29%), Positives = 89/175 (50%), Gaps = 11/175 (6%)

Query: 1027 DVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D+VF++DGS S GPE F+ V+  +  +    D+G    +V V+Q+SD P +E  L ++ S
Sbjct: 37   DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDE 1145
             + +  AV+ +   GG     G A+++    +F +   SR    + +  V+++ GKS D+
Sbjct: 97   GEHLTAAVESILYLGG-NTKTGKAIQFALDYLFAK--SSRF---LTKIAVVLTDGKSQDD 150

Query: 1146 VDDPAVELKQFGVAPFTIARNADQE--ELVKISLSPE--YVFSVSTFRELPSLEQ 1196
            V D A   +   +  F I   ++ E  EL  I+  P   YVF V  +  +  + +
Sbjct: 151  VKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIRE 205


>gi|11321565 matrilin 3 precursor [Homo sapiens]
          Length = 486

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 48/153 (31%), Positives = 86/153 (56%), Gaps = 2/153 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+VF++D S ++    F  ++ F++++I  L+IG    +VAV  YA TV+ EF    +  
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYR-AAEGIPKLLVLITGGKSLD 357
           K+ +  AV ++ PL    + +G A+    +  FT  AG R  +  IPK+ +++T G+  D
Sbjct: 143 KQSLKQAVGRITPLSTGTM-SGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201

Query: 358 EISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           ++++ A   + S I  +A+G   AD A L+ +A
Sbjct: 202 QVNEVAARAQASGIELYAVGVDRADMASLKMMA 234



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 53/176 (30%), Positives = 95/176 (53%), Gaps = 6/176 (3%)

Query: 1027 DVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSS 1085
            D+VF+ID S+S  P EF  V+T + R++D LD+G   TRVAV+ ++   K+EF L A++ 
Sbjct: 83   DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 1086 KDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSR-IEEGVPQFLVLISSGKSDD 1144
            K  ++ AV R+ P     ++ G A++      F    G+R     +P+  ++++ G+  D
Sbjct: 143  KQSLKQAVGRITPLSTGTMS-GLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201

Query: 1145 EVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSP--EYVFSVSTFRELPSLEQK 1197
            +V++ A   +  G+  + +    AD   L  ++  P  E+VF V T+  +  L  +
Sbjct: 202  QVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSR 257



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 3/166 (1%)

Query: 813 GAPAPVSGEKDVVFLLDGSEGVRS-GFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTR 871
           GA    S   D+VF++D S  VR   F  +K FV R++++LD+G    RVAVV Y+   +
Sbjct: 73  GAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVK 132

Query: 872 PEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR-ITEGVPQLL 930
            EF L +Y +KQ +  AV ++T L   T  +G A++  +       AG+R  +  +P++ 
Sbjct: 133 IEFQLQAYTDKQSLKQAVGRITPLSTGT-MSGLAIQTAMDEAFTVEAGAREPSSNIPKVA 191

Query: 931 IVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIP 976
           I++T  R  D V   +   +  G     +G+  AD+  ++ ++  P
Sbjct: 192 IIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEP 237



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 53/187 (28%), Positives = 89/187 (47%), Gaps = 7/187 (3%)

Query: 404 AAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSL 463
           AAP      G   P R   G     S   D++F++D S +V    F  V+ FV  ++++L
Sbjct: 55  AAPDGAPASGTSEPGRA-RGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTL 113

Query: 464 DIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDI---LGHLRQLQLQGGSGLNTGSALSYV 520
           DIG  + RV +V ++ T   EF L  Y  K  +   +G +  L     SGL   +A+   
Sbjct: 114 DIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEA 173

Query: 521 YANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL 580
           +     EAG      ++P++ +++T G+ +D   + A     +GI  + VG  +A+ A L
Sbjct: 174 FT---VEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASL 230

Query: 581 EQIAFNP 587
           + +A  P
Sbjct: 231 KMMASEP 237



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 44/157 (28%), Positives = 78/157 (49%), Gaps = 5/157 (3%)

Query: 631 DILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQS 689
           D++F+ D S ++   +F  V+ F+ +IID L++ P  TR+AV  Y+  VK+E +   +  
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 690 KPEILNLVKRM-KIKTGKALNLGYALDYAQRYIFVKSAGSR-IEDGVLQFLVLLVAGRSS 747
           K  +   V R+  + TG     G A+  A    F   AG+R     + +  +++  GR  
Sbjct: 143 KQSLKQAVGRITPLSTGTM--SGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQ 200

Query: 748 DRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSP 784
           D+V+  A+  + SG+  +      AD A L+ +   P
Sbjct: 201 DQVNEVAARAQASGIELYAVGVDRADMASLKMMASEP 237



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 37/156 (23%), Positives = 76/156 (48%), Gaps = 4/156 (2%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++F+ID S +   + F  +  F+  +++ L IG    RV VV ++   +  F L  Y+ 
Sbjct: 83  DLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTD 142

Query: 96  KAQVLGAV-KALGFAGGELANIGLALDFVVENHFT-RAGGSRVEEGVPQVLVLISAGPSS 153
           K  +  AV +    + G ++  GLA+   ++  FT  AG       +P+V ++++ G   
Sbjct: 143 KQSLKQAVGRITPLSTGTMS--GLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQ 200

Query: 154 DEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 189
           D++       + + +  + +G   A  A L+ +A++
Sbjct: 201 DQVNEVAARAQASGIELYAVGVDRADMASLKMMASE 236


>gi|40068485 von Willebrand factor A domain containing 1 isoform 1
           [Homo sapiens]
          Length = 445

 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 75/235 (31%), Positives = 101/235 (42%), Gaps = 32/235 (13%)

Query: 425 PEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTE 484
           P   + + D++FLLD SA+V    F  VR+FV  LV  L +G   +R  LV     P TE
Sbjct: 26  PPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTE 85

Query: 485 FSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLL 544
           F    + +       +R    + G   +TG AL Y     F EA G+  R  VP++L+ +
Sbjct: 86  FPFGQHSSGEAAQDAVRASAQRMGD-THTGLALVYAKEQLFAEASGA--RPGVPKVLVWV 142

Query: 545 TAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYL----MDDF---- 596
           T G S D        L   G+  F V   + N  EL   A  P+  +L    +DD     
Sbjct: 143 TDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIV 202

Query: 597 -----SSLPAL-PQQL-------------IQPLTTYVSG--GVEEVPLAQPESKR 630
                S L A+ PQQL               PL T  SG   +E VP AQP + R
Sbjct: 203 QELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAAR 257



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 3/152 (1%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D++FL+D S+++    F+ +R+F+ +++  L +G   ++ ++         EF F  H +
Sbjct: 34  DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
                 AVR      G   +TG AL + +  LF  ++G  A  G+PK+LV +T G S D 
Sbjct: 94  GEAAQDAVRASAQRMGDT-HTGLALVYAKEQLFAEASG--ARPGVPKVLVWVTDGGSSDP 150

Query: 359 ISQPAQELKRSSIMAFAIGNKGADQAELEEIA 390
           +  P QELK   +  F +     +  EL   A
Sbjct: 151 VGPPMQELKDLGVTVFIVSTGRGNFLELSAAA 182



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 1020 PGVGGKRDVVFLIDGSQSAGP-EFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEF 1078
            P    + D++FL+D S S    EF  VR  + +LV  L +G    R +++     P  EF
Sbjct: 27   PASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEF 86

Query: 1079 LLNAHSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLIS 1138
                HSS +  Q+AV+    + G   + G AL Y    +F    G+R   GVP+ LV ++
Sbjct: 87   PFGQHSSGEAAQDAVRASAQRMG-DTHTGLALVYAKEQLFAEASGAR--PGVPKVLVWVT 143

Query: 1139 SGKSDDEVDDPAVELKQFGVAPFTIA 1164
             G S D V  P  ELK  GV  F ++
Sbjct: 144  DGGSSDPVGPPMQELKDLGVTVFIVS 169



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 59/193 (30%), Positives = 90/193 (46%), Gaps = 16/193 (8%)

Query: 30  AAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFS 89
           A+    D++FL+D S +     F+ + +F+  L+  LP+GT  +R  +V     P T F 
Sbjct: 28  ASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFP 87

Query: 90  LDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISA 149
              +S+      AV+A     G+  + GLAL +  E  F  A G+R   GVP+VLV ++ 
Sbjct: 88  FGQHSSGEAAQDAVRASAQRMGD-THTGLALVYAKEQLFAEASGAR--PGVPKVLVWVTD 144

Query: 150 GPSSDEIRYGVVALKQASVFSF----------GLGAQAASRAELQ-HIATDDNLVFTVPE 198
           G SSD +   +  LK   V  F           L A A++ AE   H    D+L   V E
Sbjct: 145 GGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQE 204

Query: 199 FRSFGDLQEKLLP 211
            R  G + + + P
Sbjct: 205 LR--GSILDAMRP 215



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 50/172 (29%), Positives = 79/172 (45%), Gaps = 6/172 (3%)

Query: 615 SGGVEEVPLAQPESKRDILFLFDGSANLVG-QFPVVRDFLYKIIDELNVKPEGTRIAVAQ 673
           SG     P + P    D++FL D SA++   +F  VR+F+ +++  L +     R ++  
Sbjct: 20  SGAERGPPASAPRG--DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVH 77

Query: 674 YSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDG 733
                  E  F +H S     + V+    + G   + G AL YA+  +F +++G+R   G
Sbjct: 78  VGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDT-HTGLALVYAKEQLFAEASGAR--PG 134

Query: 734 VLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPA 785
           V + LV +  G SSD V  P   LK  GV  FI      +  EL     +PA
Sbjct: 135 VPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPA 186


>gi|31657142 integrin, alpha 1 precursor [Homo sapiens]
          Length = 1179

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 42/145 (28%), Positives = 79/145 (54%), Gaps = 6/145 (4%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           DIV ++DGS+++    ++++  F+  +++R++IG    QV + QY + V  EF  N + +
Sbjct: 172 DIVIVLDGSNSI--YPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSS 229

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLD- 357
             EV+ A +K+    G    T   +D  R   FT + G  A  G+ K++V++T G+S D 
Sbjct: 230 TEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARG--ARRGVKKVMVIVTDGESHDN 287

Query: 358 -EISQPAQELKRSSIMAFAIGNKGA 381
             + +  Q+ +  +I  F+I   G+
Sbjct: 288 HRLKKVIQDCEDENIQRFSIAILGS 312



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 4/129 (3%)

Query: 29  QAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMF 88
           Q      DI+ ++DGSN+     +  +  FL +LLE++ IG +Q +VG+VQ+ +     F
Sbjct: 165 QECSTQLDIVIVLDGSNSI--YPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEF 222

Query: 89  SLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLIS 148
           +L+ YS+  +VL A K +   GG      L +D   +  FT A G+R   GV +V+V+++
Sbjct: 223 NLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR--RGVKKVMVIVT 280

Query: 149 AGPSSDEIR 157
            G S D  R
Sbjct: 281 DGESHDNHR 289



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 36/118 (30%), Positives = 67/118 (56%), Gaps = 3/118 (2%)

Query: 1027 DVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSK 1086
            D+V ++DGS S  P +  V   +  L++ +D+G   T+V ++Q+ ++   EF LN +SS 
Sbjct: 172  DIVIVLDGSNSIYP-WDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSST 230

Query: 1087 DEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDD 1144
            +EV  A +++  +GGRQ      ++   +  F    G+R   GV + +V+++ G+S D
Sbjct: 231  EEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR--RGVKKVMVIVTDGESHD 286



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 38/127 (29%), Positives = 72/127 (56%), Gaps = 8/127 (6%)

Query: 429 SNKRDIIFLLDGSANVGKTNFPY--VRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFS 486
           S + DI+ +LDGS ++    +P+  V  F+ +L+  +DIG    +VG+VQ+ +    EF+
Sbjct: 168 STQLDIVIVLDGSNSI----YPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFN 223

Query: 487 LNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTA 546
           LN Y +  ++L   +++  +GG    T   +       FTEA G+  R  V ++++++T 
Sbjct: 224 LNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGA--RRGVKKVMVIVTD 281

Query: 547 GQSEDSY 553
           G+S D++
Sbjct: 282 GESHDNH 288



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 8/147 (5%)

Query: 802 QIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRV 861
           Q+VN +  V        S + D+V +LDGS  +   +  +  F+  ++E +D+G  + +V
Sbjct: 156 QVVNSIAPVQE-----CSTQLDIVIVLDGSNSIYP-WDSVTAFLNDLLERMDIGPKQTQV 209

Query: 862 AVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGSR 921
            +VQY +    EF LN Y + ++V+ A +++   GG    T   ++   +     + G+R
Sbjct: 210 GIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR 269

Query: 922 ITEGVPQLLIVLTADRSGDDVRNPSVV 948
              GV ++++++T   S D+ R   V+
Sbjct: 270 --RGVKKVMVIVTDGESHDNHRLKKVI 294



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 32/127 (25%), Positives = 70/127 (55%), Gaps = 3/127 (2%)

Query: 622 PLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVE 681
           P+ +  ++ DI+ + DGS N +  +  V  FL  +++ +++ P+ T++ + QY ++V  E
Sbjct: 163 PVQECSTQLDIVIVLDGS-NSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHE 221

Query: 682 SRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLL 741
              +++ S  E+L   K++  + G+       +D A++  F ++ G+R   GV + +V++
Sbjct: 222 FNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGAR--RGVKKVMVIV 279

Query: 742 VAGRSSD 748
             G S D
Sbjct: 280 TDGESHD 286


>gi|87196339 collagen, type VI, alpha 1 precursor [Homo sapiens]
          Length = 1028

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 97/372 (26%), Positives = 141/372 (37%), Gaps = 54/372 (14%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRL--------EIGQDLIQVAVAQYADTVRPE 290
           D++F++D S ++GL NF   +DF+ KVI RL        E GQ      V QY+ +   E
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQS--YAGVVQYSHSQMQE 672

Query: 291 FYFNTHPTKREVITAVRKMKPLDGSA--LYTGSALDFVRNNLFTSSAGYRAAEGIPKLLV 348
                 P+ R V      +K L   A   +TG AL + R+ L   S   R A      LV
Sbjct: 673 HVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIA------LV 726

Query: 349 LITGGKSLDEISQPAQELKRSSIMAFAIGNK-------GADQAE------LEEIAFDSSL 395
           +  G       + P   L    I   ++G K       G+DQ        L        L
Sbjct: 727 ITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGL 786

Query: 396 VFIPAEFRAAPLQGMLPGLLAPLRTLSGTPE-----VHSNKRDIIFLLDGSANVGKTNFP 450
             +   +        L  + A +      P+       S+  DI  LLDGSA+VG  NF 
Sbjct: 787 SLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFD 846

Query: 451 YVRDFVMNLVNS-LDIGN----DNIRVGLVQFSDT---PVTEFSLNTYQTKSDILGHLRQ 502
             + F   L    L  G      ++RV +VQ+S T        SL   Q  + +   +  
Sbjct: 847 TTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDA 906

Query: 503 LQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSED----SYLQAAN 558
           +        +   AL YV    + EA     ++     LLL + G S+     +  +A  
Sbjct: 907 MDFI-NDATDVNDALGYV-TRFYREASSGAAKKR----LLLFSDGNSQGATPAAIEKAVQ 960

Query: 559 ALTRAGILTFCV 570
              RAGI  F V
Sbjct: 961 EAQRAGIEIFVV 972



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 88/335 (26%), Positives = 135/335 (40%), Gaps = 60/335 (17%)

Query: 631 DILFLFDGSANL-VGQFPVVRDFLYKIIDELN------VKPEGTRIAVAQYSDDVKVESR 683
           D+LF+ D S ++ +  F + +DF+ K+ID L+       +P  +   V QYS      S+
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYS-----HSQ 669

Query: 684 FDEHQS--KPEILNL------VKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
             EH S   P I N+      +K ++   G     G AL Y +  +   S  +RI     
Sbjct: 670 MQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFT-GEALQYTRDQLLPPSPNNRIA---- 724

Query: 736 QFLVLLVAGRSSDRVDG-PASNLKQSGVVPFIFQAKNAD---PAELEQIVLSPAFILAAE 791
              +++  GRS  + D  P + L   G+       K+     P   +  V+S   +  ++
Sbjct: 725 ---LVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQ 781

Query: 792 SLPKIGDLHPQIVNLL----------------KSVHNGAPAPVSGEKDVVFLLDGSEGVR 835
             P +  +      LL                K      P   S   D+  LLDGS  V 
Sbjct: 782 GRPGLSLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVG 841

Query: 836 S-GFPLLKEFVQRVVESL------DVGQDRVRVAVVQYS--DRTRPE-FYLNSYMNKQDV 885
           S  F   K F +R+ E        D   D VRVAVVQYS   + RPE   L    N   +
Sbjct: 842 SHNFDTTKRFAKRLAERFLTAGRTDPAHD-VRVAVVQYSGTGQQRPERASLQFLQNYTAL 900

Query: 886 VNAVRQLTLLGGPTPNTGAALEFVLRNILVSSAGS 920
            +AV  +  +   T +   AL +V R    +S+G+
Sbjct: 901 ASAVDAMDFINDAT-DVNDALGYVTRFYREASSGA 934



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 89/373 (23%), Positives = 151/373 (40%), Gaps = 47/373 (12%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKL------PIGTQQIRVGVVQFS-DEPRTMF 88
           D++F++D S + G  NF +  DF+V ++++L           Q   GVVQ+S  + +   
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHV 674

Query: 89  SLDTYSTK--AQVLGAVKALGF-AGGELANIGLALDFVVENHFTRAGGSRV--------- 136
           SL + S +   ++  A+K+L + AGG     G AL +  +     +  +R+         
Sbjct: 675 SLRSPSIRNVQELKEAIKSLQWMAGGTFT--GEALQYTRDQLLPPSPNNRIALVITDGRS 732

Query: 137 --EEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVF 194
             +     + VL S G         VV++    VF F  G+   +    Q +A       
Sbjct: 733 DTQRDTTPLNVLCSPG-------IQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPG 785

Query: 195 TVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLAN 254
                 ++ +L E      V  AQ  I  K P     +   +  DI  L+DGS+++G  N
Sbjct: 786 LSLVKENYAELLEDAFLKNV-TAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHN 844

Query: 255 FNAIRDFIAKVIQR-LEIGQ----DLIQVAVAQYADT--VRPEFYFNTHPTKREVITAVR 307
           F+  + F  ++ +R L  G+      ++VAV QY+ T   RPE            + +  
Sbjct: 845 FDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAV 904

Query: 308 KMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLD----EISQPA 363
                   A     AL +V      +S+G        K L+L + G S       I +  
Sbjct: 905 DAMDFINDATDVNDALGYVTRFYREASSG-----AAKKRLLLFSDGNSQGATPAAIEKAV 959

Query: 364 QELKRSSIMAFAI 376
           QE +R+ I  F +
Sbjct: 960 QEAQRAGIEIFVV 972



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 65/275 (23%), Positives = 112/275 (40%), Gaps = 42/275 (15%)

Query: 433 DIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD------IGNDNIRVGLVQFSDTPVTE-F 485
           D++F+LD S ++G  NF   +DFV+ +++ L               G+VQ+S + + E  
Sbjct: 615 DLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHV 674

Query: 486 SLNTYQTKS--DILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLL 543
           SL +   ++  ++   ++ LQ   G G  TG AL Y        +  +RI        L+
Sbjct: 675 SLRSPSIRNVQELKEAIKSLQWMAG-GTFTGEALQYTRDQLLPPSPNNRI-------ALV 726

Query: 544 LTAGQSEDSY-LQAANALTRAGI----------LTFCVGASQANKAELEQIA---FNPSL 589
           +T G+S+        N L   GI            F  G+ Q N    + +A     P L
Sbjct: 727 ITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGL 786

Query: 590 VYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP---ESKRDILFLFDGSANLVG-Q 645
             + ++++ L  L    ++ +T  +    +      P    S  DI  L DGSA++    
Sbjct: 787 SLVKENYAEL--LEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHN 844

Query: 646 FPVVRDFLYKIIDEL-----NVKPEGTRIAVAQYS 675
           F   + F  ++ +              R+AV QYS
Sbjct: 845 FDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYS 879



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 14/126 (11%)

Query: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEK-LPIG----TQQIRVGVVQFS---DEPRT 86
           ADI  L+DGS + GS NF     F   L E+ L  G       +RV VVQ+S    +   
Sbjct: 828 ADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPE 887

Query: 87  MFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVL 146
             SL        +  AV A+ F   +  ++  AL +V   +   + G+  +      L+L
Sbjct: 888 RASLQFLQNYTALASAVDAMDFI-NDATDVNDALGYVTRFYREASSGAAKKR-----LLL 941

Query: 147 ISAGPS 152
            S G S
Sbjct: 942 FSDGNS 947


>gi|38569398 integrin, alpha 10 precursor [Homo sapiens]
          Length = 1167

 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 9/154 (5%)

Query: 417 PLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPY--VRDFVMNLVNSLDIGNDNIRVGL 474
           P  +L+ T +      D++ +LDGS ++    +P+  V+ F+  LV  L I  + I+VGL
Sbjct: 151 PQGSLAPTAQRCPTYMDVVIVLDGSNSI----YPWSEVQTFLRRLVGKLFIDPEQIQVGL 206

Query: 475 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534
           VQ+ ++PV E+SL  ++TK +++   + L  + G    T  A+       F+++ G   R
Sbjct: 207 VQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGG--R 264

Query: 535 EHVPQLLLLLTAGQSED-SYLQAANALTRAGILT 567
               +LL+++T G+S D   L AA     AG +T
Sbjct: 265 PEAARLLVVVTDGESHDGEELPAALKACEAGRVT 298



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 53/199 (26%), Positives = 93/199 (46%), Gaps = 18/199 (9%)

Query: 36  DIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYST 95
           D++ ++DGSN+     ++ +  FL  L+ KL I  +QI+VG+VQ+ + P   +SL  + T
Sbjct: 167 DVVIVLDGSNSI--YPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRT 224

Query: 96  KAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD- 154
           K +V+ A K L    G       A+       F+++ G R E    ++LV+++ G S D 
Sbjct: 225 KEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPE--AARLLVVVTDGESHDG 282

Query: 155 -EIRYGVVALKQASVFSFGLGA-------QAASRAELQHIAT-----DDNLVFTVPEFRS 201
            E+   + A +   V  +G+         Q    + L+ I T     D+   F V +  +
Sbjct: 283 EELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRTIASDPDERFFFNVTDEAA 342

Query: 202 FGDLQEKLLPYIVGVAQRH 220
             D+ + L   I G+   H
Sbjct: 343 LTDIVDALGDRIFGLEGSH 361



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 3/124 (2%)

Query: 1027 DVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSK 1086
            DVV ++DGS S  P +  V+T + RLV  L +  +  +V ++Q+ + P  E+ L    +K
Sbjct: 167  DVVIVLDGSNSIYP-WSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTK 225

Query: 1087 DEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEV 1146
            +EV  A + L  + GR+     A+       F +  G R E    + LV+++ G+S D  
Sbjct: 226  EEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPE--AARLLVVVTDGESHDGE 283

Query: 1147 DDPA 1150
            + PA
Sbjct: 284  ELPA 287



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 35/125 (28%), Positives = 65/125 (52%), Gaps = 4/125 (3%)

Query: 239 DIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPT 298
           D+V ++DGS+++    ++ ++ F+ +++ +L I  + IQV + QY ++   E+      T
Sbjct: 167 DVVIVLDGSNSI--YPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRT 224

Query: 299 KREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDE 358
           K EV+ A + +   +G    T  A+       F+ S G R      +LLV++T G+S D 
Sbjct: 225 KEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAA--RLLVVVTDGESHDG 282

Query: 359 ISQPA 363
              PA
Sbjct: 283 EELPA 287



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 32/125 (25%), Positives = 62/125 (49%), Gaps = 3/125 (2%)

Query: 631 DILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSK 690
           D++ + DGS N +  +  V+ FL +++ +L + PE  ++ + QY +    E    + ++K
Sbjct: 167 DVVIVLDGS-NSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTK 225

Query: 691 PEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRV 750
            E++   K +  + G+      A+  A    F +S G R E    + LV++  G S D  
Sbjct: 226 EEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPE--AARLLVVVTDGESHDGE 283

Query: 751 DGPAS 755
           + PA+
Sbjct: 284 ELPAA 288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,188,521
Number of Sequences: 37866
Number of extensions: 1883634
Number of successful extensions: 4964
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3823
Number of HSP's gapped (non-prelim): 389
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.