Guide to the Human Genome
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Name: TOP3A Sequence: fasta or formatted (1001aa) NCBI GI: 10835218
Description:

topoisomerase (DNA) III alpha

Referenced in:

Replication Proteins

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             7.2         72           2
 C cysteine            3.4         34           2
 D aspartate           5.0         50           2
 E glutamate           6.4         64           1
 F phenylalanine       4.4         44           2
 G glycine             7.2         72           2
 H histidine           2.6         26           1
 I isoleucine          3.9         39           2
 K lysine              5.7         57           2
 L leucine             8.5         85           2
 M methionine          2.2         22           1
 N asparagine          3.5         35           2
 P proline             7.0         70           3
 Q glutamine           5.5         55           2
 R arginine            7.3         73           3
 S serine              5.7         57           3
 T threonine           5.2         52           2
 V valine              5.8         58           2
 W tryptophan          1.1         11           1
 Y tyrosine            2.5         25           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   topoisomerase (DNA) III alpha 
TOP3B                 0.182   topoisomerase (DNA) III beta 
NEIL3                 0.017   nei endonuclease VIII-like 3 
APEX2                 0.010   apurinic/apyrimidinic endonuclease 2 
COL3A1                0.007   collagen type III alpha 1 preproprotein 
ERI2                  0.007   exoribonuclease 2 isoform 1 
SPOCD1                0.006   SPOC domain containing 1 
FOXI3                 0.006   forkhead box I3 
KIAA1853              0.005   KIAA1853 protein 
BSN                   0.005   bassoon protein 
COL4A5                0.005   type IV collagen alpha 5 isoform 2 precursor 
COL4A5                0.005   type IV collagen alpha 5 isoform 1 precursor 
COL4A5                0.005   type IV collagen alpha 5 isoform 3 precursor 
COL5A3                0.005   collagen, type V, alpha 3 preproprotein 
C14orf4               0.004   chromosome 14 open reading frame 4 
COL1A2                0.004   alpha 2 type I collagen 
SNRPB                 0.004   small nuclear ribonucleoprotein polypeptide B/B' iso...
SNRPB                 0.004   small nuclear ribonucleoprotein polypeptide B/B' isof...
COL4A3                0.004   alpha 3 type IV collagen isoform 5 precursor 
COL4A3                0.004   alpha 3 type IV collagen isoform 4 precursor 
COL4A3                0.004   alpha 3 type IV collagen isoform 2 precursor 
COL4A3                0.004   alpha 3 type IV collagen isoform 1 precursor 
COL15A1               0.004   alpha 1 type XV collagen precursor 
CHRM1                 0.004   cholinergic receptor, muscarinic 1 
SALL3                 0.004   sal-like 3 
SLC12A9               0.003   solute carrier family 12 (potassium/chloride transpo...
TTF2                  0.003   transcription termination factor, RNA polymerase II ...
MEX3D                 0.003   ring finger and KH domain containing 1 
CNOT3                 0.003   CCR4-NOT transcription complex, subunit 3 
TSC22D2               0.003   TSC22 domain family, member 2 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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