Guide to the Human Genome
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Name: APEX2 Sequence: fasta or formatted (518aa) NCBI GI: 18375507
Description:

apurinic/apyrimidinic endonuclease 2

Referenced in:

DNases, Recombination, and DNA Repair

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             7.3         38           2
 C cysteine            3.5         18           1
 D aspartate           4.2         22           1
 E glutamate           5.8         30           2
 F phenylalanine       4.1         21           2
 G glycine             6.8         35           2
 H histidine           1.9         10           1
 I isoleucine          2.9         15           2
 K lysine              4.4         23           2
 L leucine            10.0         52           2
 M methionine          1.7          9           1
 N asparagine          3.9         20           2
 P proline             7.5         39           2
 Q glutamine           5.0         26           1
 R arginine            7.1         37           2
 S serine              7.9         41           2
 T threonine           5.6         29           1
 V valine              6.8         35           2
 W tryptophan          1.4          7           1
 Y tyrosine            2.1         11           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   apurinic/apyrimidinic endonuclease 2 
APEX1                 0.056   APEX nuclease 1 
APEX1                 0.056   APEX nuclease 1 
APEX1                 0.056   APEX nuclease 1 
NEIL3                 0.023   nei endonuclease VIII-like 3 
TOP3A                 0.020   topoisomerase (DNA) III alpha 
DOT1L                 0.009   DOT1-like, histone H3 methyltransferase 
NCOA6                 0.008   nuclear receptor coactivator 6 
SHANK1                0.008   SH3 and multiple ankyrin repeat domains 1 
ERI2                  0.008   exoribonuclease 2 isoform 1 
HTRA2                 0.007   HtrA serine peptidase 2 isoform 1 preproprotein [Homo...
HTRA2                 0.007   HtrA serine peptidase 2 isoform 2 
ADAMTS7               0.007   ADAM metallopeptidase with thrombospondin type 1 mot...
KIAA1486              0.007   hypothetical protein LOC57624 
LOC100293817          0.007   PREDICTED: similar to hCG1811893 
LOC100128084          0.007   PREDICTED: hypothetical protein 
MLL2                  0.007   myeloid/lymphoid or mixed-lineage leukemia 2 
MICAL3                0.007   microtubule associated monoxygenase, calponin and L...
MLL3                  0.006   myeloid/lymphoid or mixed-lineage leukemia 3 
PPP1R15B              0.006   protein phosphatase 1, regulatory subunit 15B [Homo...
MLXIP                 0.006   MLX interacting protein 
LOC100131880          0.005   PREDICTED: hypothetical protein 
LOC100131880          0.005   PREDICTED: hypothetical protein 
IDH3A                 0.005   isocitrate dehydrogenase 3 (NAD+) alpha precursor [Ho...
TTF2                  0.005   transcription termination factor, RNA polymerase II ...
USH2A                 0.005   usherin isoform B 
MLL5                  0.005   myeloid/lymphoid or mixed-lineage leukemia 5 
MLL5                  0.005   myeloid/lymphoid or mixed-lineage leukemia 5 
SPEN                  0.005   spen homolog, transcriptional regulator 
SPERT                 0.005   spermatid associated 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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