Search of human proteins with 229577436

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
         (753 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]      1481   0.0  
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              442   e-124
gi|6005942 valosin-containing protein [Homo sapiens]                  425   e-119
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 365   e-101
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 365   e-101
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           257   3e-68
gi|4505725 peroxin1 [Homo sapiens]                                    239   7e-63
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            190   4e-48
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           184   3e-46
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            177   4e-44
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   175   2e-43
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   174   3e-43
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   174   3e-43
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   174   3e-43
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            168   2e-41
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               168   2e-41
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               168   2e-41
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             168   2e-41
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     166   6e-41
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            166   7e-41
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     162   1e-39
gi|31742536 fidgetin-like 1 [Homo sapiens]                            160   3e-39
gi|112789543 fidgetin-like 1 [Homo sapiens]                           160   3e-39
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      157   4e-38
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       157   4e-38
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              156   6e-38
gi|156564401 vesicle-fusing ATPase [Homo sapiens]                     147   5e-35
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          144   4e-34
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          144   4e-34
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   144   4e-34

>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score = 1481 bits (3833), Expect = 0.0
 Identities = 753/753 (100%), Positives = 753/753 (100%)

Query: 1   MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCT 60
           MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCT
Sbjct: 1   MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCT 60

Query: 61  AWPRRDGADGFVQLDPLCASPGAAVGASRSRRSLSLNRLLLVPCPPLRRVAVWPVLRERA 120
           AWPRRDGADGFVQLDPLCASPGAAVGASRSRRSLSLNRLLLVPCPPLRRVAVWPVLRERA
Sbjct: 61  AWPRRDGADGFVQLDPLCASPGAAVGASRSRRSLSLNRLLLVPCPPLRRVAVWPVLRERA 120

Query: 121 GAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTP 180
           GAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTP
Sbjct: 121 GAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTP 180

Query: 181 RTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLA 240
           RTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLA
Sbjct: 181 RTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLA 240

Query: 241 GPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLL 300
           GPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLL
Sbjct: 241 GPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLL 300

Query: 301 FLDEMDALCPQRGSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRF 360
           FLDEMDALCPQRGSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRF
Sbjct: 301 FLDEMDALCPQRGSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRF 360

Query: 361 DREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
           DREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL
Sbjct: 361 DREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420

Query: 421 LHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSI 480
           LHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSI
Sbjct: 421 LHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSI 480

Query: 481 EWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVG 540
           EWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVG
Sbjct: 481 EWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVG 540

Query: 541 DSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLK 600
           DSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLK
Sbjct: 541 DSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLK 600

Query: 601 TIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLS 660
           TIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLS
Sbjct: 601 TIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLS 660

Query: 661 ILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFL 720
           ILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFL
Sbjct: 661 ILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFL 720

Query: 721 KSLKTVKPSLSCKDLALYENLFKKEGFSNVEGI 753
           KSLKTVKPSLSCKDLALYENLFKKEGFSNVEGI
Sbjct: 721 KSLKTVKPSLSCKDLALYENLFKKEGFSNVEGI 753


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  442 bits (1137), Expect = e-124
 Identities = 241/560 (43%), Positives = 348/560 (62%), Gaps = 40/560 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GGLS    ++RE++ LPL+ P    + G+  PRGVLL GPPG GKT + RAVA E GA 
Sbjct: 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAY 414

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPES 319
           +  ++ P +     GETE  +R++F  A     R PS++F+DE+DALCP+R       E 
Sbjct: 415 VSVINGPEIISKFYGETEAKLRQIFAEA---TLRHPSIIFIDELDALCPKREGAQNEVEK 471

Query: 320 RVVAQVLTLLDGASGD---REVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
           RVVA +LTL+DG   +    +V+V+GATNRP ALD ALRRPGRFD+E+ IG P  + R +
Sbjct: 472 RVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLD 531

Query: 377 ILQVITSKMP-ISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEI 435
           ILQ +  ++P + +  +L  LA    GYVGADL  LC EA + AL    K Q N    ++
Sbjct: 532 ILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKV 591

Query: 436 ---------DFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKF 486
                    DFL+A  +I+PS+ R +   +D+  V W +IGGLE +KLKL+Q++EWPLK 
Sbjct: 592 AGLVKITLKDFLQAMNDIRPSAMREIA--IDVPNVSWSDIGGLESIKLKLEQAVEWPLKH 649

Query: 487 PWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVL 546
           P  F+RMG+  PKGVLLYGPPGC+KT + +ALA     +F+++ G +L + +VG+SE+ +
Sbjct: 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAV 709

Query: 547 SQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRG 606
            + FR+ARA  P+I+F DE+D++   R +S    +V +RVL+ LL E+DG+         
Sbjct: 710 RETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQL------ 763

Query: 607 SKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCT 666
                        + V I+AATNRPD +D AL+RPGR+D+IIY+P PD   R  I K+  
Sbjct: 764 -------------KDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQF 810

Query: 667 KTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
            +MP+  +V L+ L  +T  +SGA++  +C EAALLAL+E+ + A  + + HF ++L TV
Sbjct: 811 HSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEED-IQANLIMKRHFTQALSTV 869

Query: 727 KPSLSCKDLALYENLFKKEG 746
            P +       YE+  +K G
Sbjct: 870 TPRIPESLRRFYEDYQEKSG 889



 Score =  157 bits (396), Expect = 4e-38
 Identities = 101/283 (35%), Positives = 151/283 (53%), Gaps = 34/283 (12%)

Query: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALAT 520
           V ++ IGGL      +++ IE PLK P  F   G+  P+GVLLYGPPG  KT + RA+A 
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 521 SCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGC 580
                   ++G ++ S F G++E  L QIF +A    P+I+F+DE+D++   R  ++   
Sbjct: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQN-- 467

Query: 581 DVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLR 640
           +V++RV++ LL  +DG+G                 EV    V+++ ATNRP  LD AL R
Sbjct: 468 EVEKRVVASLLTLMDGIG----------------SEVSEGQVLVLGATNRPHALDAALRR 511

Query: 641 PGRLDKIIYIPPPDHKGRLSILKVCTKTMP-IGPDVSLENLAAETCFFSGADLRNLCTEA 699
           PGR DK I I  P+ + RL IL+   + +P +  +  L  LA     + GADL+ LC EA
Sbjct: 512 PGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEA 571

Query: 700 ALLALQE-------------NGLDATTVKQEHFLKSLKTVKPS 729
            L AL+               GL   T+K   FL+++  ++PS
Sbjct: 572 GLCALRRILKKQPNLPDVKVAGLVKITLKD--FLQAMNDIRPS 612


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  425 bits (1093), Expect = e-119
 Identities = 256/683 (37%), Positives = 380/683 (55%), Gaps = 76/683 (11%)

Query: 103 PCPPLR---RVAVWPVLRERAGAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGL 159
           PCP ++   R+ V P+     G  G  N   V      L   RPI  G + +   G    
Sbjct: 104 PCPDVKYGKRIHVLPIDDTVEGITG--NLFEVYLKPYFLEAYRPIRKGDIFLVRGG---- 157

Query: 160 VAALHIVGGTPSPDPAGLVTPRTRVSLGGEP---PSEAQPQPEV---PLGGLSEAADSLR 213
           + A+        P P  +V P T +   GEP     E +   EV    +GG  +    ++
Sbjct: 158 MRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIK 217

Query: 214 ELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGS 273
           E++ LPLR+P    A+G+  PRG+LL GPPG GKT + RAVA E GA    ++ P +   
Sbjct: 218 EMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSK 277

Query: 274 RPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSR--APESRVVAQVLTLLDG 331
             GE+E N+R+ F+ A + A   P+++F+DE+DA+ P+R       E R+V+Q+LTL+DG
Sbjct: 278 LAGESESNLRKAFEEAEKNA---PAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG 334

Query: 332 ASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHV 391
                 V+V+ ATNRP+++DPALRR GRFDREV IG P    R EILQ+ T  M ++  V
Sbjct: 335 LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDV 394

Query: 392 DLGLLAEMTVGYVGADLTALCREAAMHALLHS-------EKNQDNPVIDEI-----DFLE 439
           DL  +A  T G+VGADL ALC EAA+ A+          ++  D  V++ +     DF  
Sbjct: 395 DLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRW 454

Query: 440 AFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPK 499
           A     PS+ R  +  +++  V WE+IGGLEDVK +L++ +++P++ P +F++ G+T  K
Sbjct: 455 ALSQSNPSALRETV--VEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSK 512

Query: 500 GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPA 559
           GVL YGPPGC KT L +A+A  C  +F+S+ G +L + + G+SE  + +IF +AR + P 
Sbjct: 513 GVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPC 572

Query: 560 ILFLDEIDSILGARSAS-KTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVF 618
           +LF DE+DSI  AR  +   G    +RV++ +L E+DG+  K                  
Sbjct: 573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK------------------ 614

Query: 619 NRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLE 678
            ++V II ATNRPD++D A+LRPGRLD++IYIP PD K R++ILK   +  P+  DV LE
Sbjct: 615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLE 673

Query: 679 NLAAETCFFSGADLRNLCTEAALLALQEN----------------------GLDATTVKQ 716
            LA  T  FSGADL  +C  A  LA++E+                            +++
Sbjct: 674 FLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRR 733

Query: 717 EHFLKSLKTVKPSLSCKDLALYE 739
           +HF ++++  + S+S  D+  YE
Sbjct: 734 DHFEEAMRFARRSVSDNDIRKYE 756


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  365 bits (937), Expect = e-101
 Identities = 227/604 (37%), Positives = 339/604 (56%), Gaps = 99/604 (16%)

Query: 211 SLRELLRL--PLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAP 268
           +L+E+ ++   +R+P     LG+  PRGVLL GPPG GKT L  A+A E    +L V+AP
Sbjct: 167 TLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAP 226

Query: 269 ALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESRVVAQVL 326
            +     GE+E+ +R +F++A    S  P ++F+DE+DA+ P+R   S+  E R+VAQ+L
Sbjct: 227 EIVSGVSGESEQKLRELFEQA---VSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL 283

Query: 327 TLLD---GASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITS 383
           T +D     +    V+V+GATNRPD+LDPALRR GRFDRE+ +G P    R+ ILQ +  
Sbjct: 284 TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCR 343

Query: 384 KMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLH-----SEKNQDNPVIDEI--- 435
           K+ +    D   LA +T G+VGADL ALCREAAM A+        E+ + NP ++++   
Sbjct: 344 KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSK 403

Query: 436 ---------------------------------------------DFLEAFKNIQPSSFR 450
                                                        DF+ A  ++QPS+ R
Sbjct: 404 GVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR 463

Query: 451 SVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCA 510
              G + +  V W +IG LED++ +L  +I  P++ P +F  +GL  P GVLL GPPGC 
Sbjct: 464 E--GFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG 521

Query: 511 KTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSIL 570
           KT L +A+A     +F+SV G +L + +VG+SE+ + Q+F++A+ S P ++F DE+D++ 
Sbjct: 522 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 581

Query: 571 GARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNR 630
             RS  +TG  V  RV++ LL E+DG+  +              Q+VF     I+AATNR
Sbjct: 582 PRRSDRETGASV--RVVNQLLTEMDGLEAR--------------QQVF-----IMAATNR 620

Query: 631 PDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKT---MPIGPDVSLENLAAE-TC- 685
           PD++D A+LRPGRLDK +++  P    RL+ILK  TK     P+  DV+LE +A +  C 
Sbjct: 621 PDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCD 680

Query: 686 FFSGADLRNLCTEAALLALQE--------NGLDATTVKQEHFLKSLKTVKPSLSCKDLAL 737
            ++GADL  L  EA++ AL++        N      V  +HF ++ K V+ S+S KD  +
Sbjct: 681 CYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIM 740

Query: 738 YENL 741
           YE L
Sbjct: 741 YERL 744



 Score =  177 bits (449), Expect = 3e-44
 Identities = 108/259 (41%), Positives = 148/259 (57%), Gaps = 16/259 (6%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +G L +  + L   +  P+R P    ALGL  P GVLLAGPPG GKT L +AVA E+G  
Sbjct: 477 IGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLN 536

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSR--APES 319
            ++V  P L     GE+E  VR+VFQRA+  A   P ++F DE+DALCP+R  R      
Sbjct: 537 FISVKGPELLNMYVGESERAVRQVFQRAKNSA---PCVIFFDEVDALCPRRSDRETGASV 593

Query: 320 RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQ 379
           RVV Q+LT +DG    ++V ++ ATNRPD +DPA+ RPGR D+ + +G P    R  IL+
Sbjct: 594 RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILK 653

Query: 380 VIT---SKMPISSHVDLGLLAE--MTVGYVGADLTALCREAAMHALLHSEKNQDNP---- 430
            IT   +K P+ + V+L  +A       Y GADL+AL REA++ AL      Q +     
Sbjct: 654 TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKG 713

Query: 431 --VIDEIDFLEAFKNIQPS 447
              +    F EAFK ++ S
Sbjct: 714 ELKVSHKHFEEAFKKVRSS 732



 Score =  133 bits (334), Expect = 7e-31
 Identities = 88/248 (35%), Positives = 132/248 (53%), Gaps = 21/248 (8%)

Query: 458 IKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRA 517
           I  V +E++GG  D+ LK    +   ++ P  +  +G+  P+GVLL+GPPGC KT L  A
Sbjct: 153 ISNVKFEDVGG-NDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA 211

Query: 518 LATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARS-AS 576
           +A       + V+  ++ S   G+SE+ L ++F QA ++ P I+F+DEID+I   R  AS
Sbjct: 212 IAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVAS 271

Query: 577 KTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDT 636
           K   D++ R+++ LL  +D +       R                V++I ATNRPD LD 
Sbjct: 272 K---DMERRIVAQLLTCMDDLNNVAATAR----------------VLVIGATNRPDSLDP 312

Query: 637 ALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLC 696
           AL R GR D+ I +  PD   R  IL+   + + +       +LA  T  F GADL  LC
Sbjct: 313 ALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALC 372

Query: 697 TEAALLAL 704
            EAA+ A+
Sbjct: 373 REAAMCAV 380


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  365 bits (937), Expect = e-101
 Identities = 227/604 (37%), Positives = 339/604 (56%), Gaps = 99/604 (16%)

Query: 211 SLRELLRL--PLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAP 268
           +L+E+ ++   +R+P     LG+  PRGVLL GPPG GKT L  A+A E    +L V+AP
Sbjct: 273 TLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAP 332

Query: 269 ALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESRVVAQVL 326
            +     GE+E+ +R +F++A    S  P ++F+DE+DA+ P+R   S+  E R+VAQ+L
Sbjct: 333 EIVSGVSGESEQKLRELFEQA---VSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL 389

Query: 327 TLLD---GASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITS 383
           T +D     +    V+V+GATNRPD+LDPALRR GRFDRE+ +G P    R+ ILQ +  
Sbjct: 390 TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCR 449

Query: 384 KMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLH-----SEKNQDNPVIDEI--- 435
           K+ +    D   LA +T G+VGADL ALCREAAM A+        E+ + NP ++++   
Sbjct: 450 KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSK 509

Query: 436 ---------------------------------------------DFLEAFKNIQPSSFR 450
                                                        DF+ A  ++QPS+ R
Sbjct: 510 GVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR 569

Query: 451 SVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCA 510
              G + +  V W +IG LED++ +L  +I  P++ P +F  +GL  P GVLL GPPGC 
Sbjct: 570 E--GFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG 627

Query: 511 KTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSIL 570
           KT L +A+A     +F+SV G +L + +VG+SE+ + Q+F++A+ S P ++F DE+D++ 
Sbjct: 628 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 687

Query: 571 GARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNR 630
             RS  +TG  V  RV++ LL E+DG+  +              Q+VF     I+AATNR
Sbjct: 688 PRRSDRETGASV--RVVNQLLTEMDGLEAR--------------QQVF-----IMAATNR 726

Query: 631 PDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKT---MPIGPDVSLENLAAE-TC- 685
           PD++D A+LRPGRLDK +++  P    RL+ILK  TK     P+  DV+LE +A +  C 
Sbjct: 727 PDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCD 786

Query: 686 FFSGADLRNLCTEAALLALQE--------NGLDATTVKQEHFLKSLKTVKPSLSCKDLAL 737
            ++GADL  L  EA++ AL++        N      V  +HF ++ K V+ S+S KD  +
Sbjct: 787 CYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIM 846

Query: 738 YENL 741
           YE L
Sbjct: 847 YERL 850



 Score =  177 bits (449), Expect = 3e-44
 Identities = 108/259 (41%), Positives = 148/259 (57%), Gaps = 16/259 (6%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +G L +  + L   +  P+R P    ALGL  P GVLLAGPPG GKT L +AVA E+G  
Sbjct: 583 IGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLN 642

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSR--APES 319
            ++V  P L     GE+E  VR+VFQRA+  A   P ++F DE+DALCP+R  R      
Sbjct: 643 FISVKGPELLNMYVGESERAVRQVFQRAKNSA---PCVIFFDEVDALCPRRSDRETGASV 699

Query: 320 RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQ 379
           RVV Q+LT +DG    ++V ++ ATNRPD +DPA+ RPGR D+ + +G P    R  IL+
Sbjct: 700 RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILK 759

Query: 380 VIT---SKMPISSHVDLGLLAE--MTVGYVGADLTALCREAAMHALLHSEKNQDNP---- 430
            IT   +K P+ + V+L  +A       Y GADL+AL REA++ AL      Q +     
Sbjct: 760 TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKG 819

Query: 431 --VIDEIDFLEAFKNIQPS 447
              +    F EAFK ++ S
Sbjct: 820 ELKVSHKHFEEAFKKVRSS 838



 Score =  133 bits (334), Expect = 7e-31
 Identities = 88/248 (35%), Positives = 132/248 (53%), Gaps = 21/248 (8%)

Query: 458 IKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRA 517
           I  V +E++GG  D+ LK    +   ++ P  +  +G+  P+GVLL+GPPGC KT L  A
Sbjct: 259 ISNVKFEDVGG-NDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA 317

Query: 518 LATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARS-AS 576
           +A       + V+  ++ S   G+SE+ L ++F QA ++ P I+F+DEID+I   R  AS
Sbjct: 318 IAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVAS 377

Query: 577 KTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDT 636
           K   D++ R+++ LL  +D +       R                V++I ATNRPD LD 
Sbjct: 378 K---DMERRIVAQLLTCMDDLNNVAATAR----------------VLVIGATNRPDSLDP 418

Query: 637 ALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLC 696
           AL R GR D+ I +  PD   R  IL+   + + +       +LA  T  F GADL  LC
Sbjct: 419 ALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALC 478

Query: 697 TEAALLAL 704
            EAA+ A+
Sbjct: 479 REAAMCAV 486


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  257 bits (656), Expect = 3e-68
 Identities = 197/615 (32%), Positives = 311/615 (50%), Gaps = 78/615 (12%)

Query: 162 ALHIVGGTPSPDPAGLVTPRTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLR 221
           +L++VG T SP P               P  E+     +   GL      L  +L+  L+
Sbjct: 408 SLYMVGSTLSPVP-------------WLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQ 454

Query: 222 YPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEEN 281
              AL    L     VLL GPPG GKT +V A     G  LL V   +L     G  E  
Sbjct: 455 PGGAL----LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETK 510

Query: 282 VRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPESRVVAQVLTLL---DGASGDREV 338
           ++ +F RAR      P++L L  +D L   R     ++RV+A +  LL   D  +    +
Sbjct: 511 LQAIFSRARRCR---PAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPL 567

Query: 339 VVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAE 398
           +VV  T+R   L   ++    F  E+ +   +  QR  IL+ +T+ +P+   V+L  LA 
Sbjct: 568 MVVATTSRAQDLPADVQTA--FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLAR 625

Query: 399 MTVGYVGADLTALCREAAMHALLH----------SEKNQDN------PVIDEIDFLEAFK 442
              G+V  DL AL   ++  A             +E+++        P++ E DF +A +
Sbjct: 626 RCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAE-DFGQALE 684

Query: 443 NIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502
            +Q +  ++V G   I  V W ++GGL++VK ++ ++I+ PL+ P E + +GL +  G+L
Sbjct: 685 QLQTAHSQAV-GAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHP-ELLSLGLRR-SGLL 741

Query: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562
           L+GPPG  KT L +A+AT C  +F+SV G +L + +VG SE+ + ++F +ARA+ P I+F
Sbjct: 742 LHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIF 801

Query: 563 LDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSV 622
            DE+DS+  +R  S     V +RV+S LL ELDG+                 Q+VF    
Sbjct: 802 FDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGL--------------HSTQDVF---- 843

Query: 623 MIIAATNRPDVLDTALLRPGRLDKIIYI-PPPDHKGRLSILKVCTKTMPIGPDVSLENLA 681
            +I ATNRPD+LD ALLRPGR DK++++    D   +L +L   T+   + P VSL N+ 
Sbjct: 844 -VIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNV- 901

Query: 682 AETC--FFSGADLRNLCTEAALLALQ----------ENGLDATTVKQEHFLKSLKTVKPS 729
            + C    +GADL +LC++A   AL+          E G  A  +  E  L++   ++PS
Sbjct: 902 LDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961

Query: 730 LSCKDLALYENLFKK 744
           +S ++L  Y+ + +K
Sbjct: 962 VSEQELLRYKRIQRK 976


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  239 bits (610), Expect = 7e-63
 Identities = 185/527 (35%), Positives = 277/527 (52%), Gaps = 56/527 (10%)

Query: 204  GLSEAADSLRELLRLPLRYPRALTALGLAVPRG-VLLAGPPGVGKTQLVRAVAREAGAEL 262
            G+S        LL  PL   R L +L   +  G +LL G  G GK+ L +A+ +EA  +L
Sbjct: 563  GVSSLEHITHSLLGRPLS--RQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKL 620

Query: 263  LA----VSAPALQGSRPGETEENVRRVFQRA-RELASRGPSLLFLDEMDALCP------- 310
             A    V   AL+G R     EN+++  + A  E     PS++ LD++D +         
Sbjct: 621  DAHVERVDCKALRGKRL----ENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEH 676

Query: 311  QRGSRAPESRVVAQVLT--LLDGASGDREVVVVGATNRPDALDPAL---RRPGRFDREVV 365
            +    A +S+ +A  L   + +  S    V ++  +    +L P L   +    F     
Sbjct: 677  EHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQH 736

Query: 366  IGTPTLKQRKEIL-QVITSKMP--ISSHVDLGL--LAEMTVGYVGADLTALCREAAMHAL 420
            I  P  +QR EIL  VI +K+   I+   DL L  +A+ T G+V  D T L  + A+H+ 
Sbjct: 737  IQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLV-DRAIHSR 795

Query: 421  L--HSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQ 478
            L   S   ++  V+  +DF +A +   P+S RSV  L   + + W++IGGL +V+  L  
Sbjct: 796  LSRQSISTREKLVLTTLDFQKALRGFLPASLRSV-NLHKPRDLGWDKIGGLHEVRQILMD 854

Query: 479  SIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPF 538
            +I+ P K+P  F  + + Q  G+LLYGPPG  KT L   +A     +F+SV G +L S +
Sbjct: 855  TIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKY 914

Query: 539  VGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGV- 597
            +G SE+ +  IF +A+A+ P ILF DE +SI   R    TG  V +RV++ LL +LDGV 
Sbjct: 915  IGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG--VTDRVVNQLLTQLDGVE 972

Query: 598  GLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKG 657
            GL                    + V ++AAT+RPD++D ALLRPGRLDK +Y PPPD   
Sbjct: 973  GL--------------------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVS 1012

Query: 658  RLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLAL 704
            RL IL V + ++P+  DV L+++A+ T  F+GADL+ L   A L AL
Sbjct: 1013 RLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059



 Score =  160 bits (405), Expect = 4e-39
 Identities = 95/240 (39%), Positives = 134/240 (55%), Gaps = 8/240 (3%)

Query: 202  LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
            +GGL E    L + ++LP +YP     L +    G+LL GPPG GKT L   +ARE+   
Sbjct: 842  IGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMN 901

Query: 262  LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRG--SRAPES 319
             ++V  P L     G +E+ VR +F RA+   +  P +LF DE +++ P+RG  +     
Sbjct: 902  FISVKGPELLSKYIGASEQAVRDIFIRAQ---AAKPCILFFDEFESIAPRRGHDNTGVTD 958

Query: 320  RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQ 379
            RVV Q+LT LDG  G + V V+ AT+RPD +DPAL RPGR D+ V    P    R EIL 
Sbjct: 959  RVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILN 1018

Query: 380  VITSKMPISSHVDLGLLAEMTVGYVGADLTALCREA---AMHALLHSEKNQDNPVIDEID 436
            V++  +P++  VDL  +A +T  + GADL AL   A   A+H +L S   QD     + D
Sbjct: 1019 VLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSD 1078


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  190 bits (483), Expect = 4e-48
 Identities = 111/298 (37%), Positives = 175/298 (58%), Gaps = 26/298 (8%)

Query: 444 IQPSSFRSVIGLMDIKPVD---WEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKG 500
           I P+    ++ LM ++ V    +E IGGL+    ++K+ IE P+K P  F  +G+ QPKG
Sbjct: 126 ILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKG 185

Query: 501 VLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAI 560
           VLLYGPPG  KT L RA+A    C+F+ VSG++L   F+G+  +++ ++F  AR   P+I
Sbjct: 186 VLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSI 245

Query: 561 LFLDEIDSILGARSASKTGCDVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFN 619
           +F+DEIDSI  +R    +G D + +R +  LLN+LDG                       
Sbjct: 246 IFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEA-------------------T 286

Query: 620 RSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLEN 679
           +++ +I ATNR D+LD+ALLRPGR+D+ I  PPP+ + RL ILK+ ++ M +   ++L  
Sbjct: 287 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK 346

Query: 680 LAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVKPSLSCKDLAL 737
           +A      SGA+++ +CTEA + AL+E  +  T   QE F  ++  V    S K++++
Sbjct: 347 IAELMPGASGAEVKGVCTEAGMYALRERRVHVT---QEDFEMAVAKVMQKDSEKNMSI 401



 Score =  155 bits (391), Expect = 2e-37
 Identities = 97/267 (36%), Positives = 145/267 (54%), Gaps = 27/267 (10%)

Query: 178 VTPRTRVSLGGEP-------PSEAQPQ------PEVP------LGGLSEAADSLRELLRL 218
           VTP  RV+L  +        P++  P        +VP      +GGL +    ++E++ L
Sbjct: 108 VTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIEL 167

Query: 219 PLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGET 278
           P+++P    ALG+A P+GVLL GPPG GKT L RAVA       + VS   L     GE 
Sbjct: 168 PVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEG 227

Query: 279 EENVRRVFQRARELASRGPSLLFLDEMDALCPQR-----GSRAPESRVVAQVLTLLDGAS 333
              VR +F  ARE A   PS++F+DE+D++   R     G  +   R + ++L  LDG  
Sbjct: 228 ARMVRELFVMAREHA---PSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFE 284

Query: 334 GDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDL 393
             + + V+ ATNR D LD AL RPGR DR++    P  + R +IL++ + KM ++  ++L
Sbjct: 285 ATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINL 344

Query: 394 GLLAEMTVGYVGADLTALCREAAMHAL 420
             +AE+  G  GA++  +C EA M+AL
Sbjct: 345 RKIAELMPGASGAEVKGVCTEAGMYAL 371


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  184 bits (467), Expect = 3e-46
 Identities = 108/270 (40%), Positives = 158/270 (58%), Gaps = 23/270 (8%)

Query: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALAT 520
           V + EIGGL +   +L++ IE PL  P  F R+G+  PKG LLYGPPG  KT L RA+A+
Sbjct: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203

Query: 521 SCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGC 580
              C+F+ V  + +   ++G+S +++ ++F  AR   P I+F+DEID+I G R +  T  
Sbjct: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263

Query: 581 DVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639
           D + +R L  LLN++D  G  T+ R                 V +I ATNRPD LD ALL
Sbjct: 264 DREIQRTLMELLNQMD--GFDTLHR-----------------VKMIMATNRPDTLDPALL 304

Query: 640 RPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEA 699
           RPGRLD+ I+I  P+ + RL ILK+    +    ++  E +   +  F+GADLRN+CTEA
Sbjct: 305 RPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEA 364

Query: 700 ALLALQENGLDATTVKQEHFLKSLKTVKPS 729
            + A++    D   V QE F+K+++ V  S
Sbjct: 365 GMFAIR---ADHDFVVQEDFMKAVRKVADS 391



 Score =  154 bits (390), Expect = 2e-37
 Identities = 92/265 (34%), Positives = 144/265 (54%), Gaps = 15/265 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GGLSE    LRE++ LPL  P     +G+  P+G LL GPPG GKT L RAVA +    
Sbjct: 149 IGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCN 208

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES-- 319
            L V + ++     GE+   +R +F  AR+     P ++F+DE+DA+  +R S    +  
Sbjct: 209 FLKVVSSSIVDKYIGESARLIREMFNYARD---HQPCIIFMDEIDAIGGRRFSEGTSADR 265

Query: 320 ---RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
              R + ++L  +DG      V ++ ATNRPD LDPAL RPGR DR++ I  P  + R +
Sbjct: 266 EIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLD 325

Query: 377 ILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEID 436
           IL++    +     +D   + +++ G+ GADL  +C EA M A+       D+  + + D
Sbjct: 326 ILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI-----RADHDFVVQED 380

Query: 437 FLEAFKNIQPSSFRSVIGLMDIKPV 461
           F++A + +  S  + +   +D KPV
Sbjct: 381 FMKAVRKVADS--KKLESKLDYKPV 403


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  177 bits (448), Expect = 4e-44
 Identities = 102/265 (38%), Positives = 155/265 (58%), Gaps = 23/265 (8%)

Query: 463 WEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSC 522
           + +IGGL++   ++K+S+E PL  P  +  MG+  PKGV+LYGPPG  KT L +A+A   
Sbjct: 184 YADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQT 243

Query: 523 HCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDV 582
             +F+ V G++L   ++GD  K++ ++FR A    P+I+F+DEID+I   R  S +G + 
Sbjct: 244 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGER 303

Query: 583 Q-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRP 641
           + +R +  LLN+LDG      + RG               V +I ATNR + LD AL+RP
Sbjct: 304 EIQRTMLELLNQLDG-----FDSRG--------------DVKVIMATNRIETLDPALIRP 344

Query: 642 GRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAAL 701
           GR+D+ I  P PD K +  I ++ T  M +  DV+L++L       SGAD++ +CTEA L
Sbjct: 345 GRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGL 404

Query: 702 LALQENGLDATTVKQEHFLKSLKTV 726
           +AL+E  +  T    E F KS + V
Sbjct: 405 MALRERRMKVT---NEDFKKSKENV 426



 Score =  144 bits (364), Expect = 2e-34
 Identities = 91/257 (35%), Positives = 134/257 (52%), Gaps = 13/257 (5%)

Query: 193 EAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVR 252
           +A  +    +GGL      ++E + LPL +P     +G+  P+GV+L GPPG GKT L +
Sbjct: 178 KAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAK 237

Query: 253 AVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR 312
           AVA +  A  L V    L     G+  + VR +F+ A E A   PS++F+DE+DA+  +R
Sbjct: 238 AVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHA---PSIVFIDEIDAIGTKR 294

Query: 313 -----GSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIG 367
                G      R + ++L  LDG     +V V+ ATNR + LDPAL RPGR DR++   
Sbjct: 295 YDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFP 354

Query: 368 TPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQ 427
            P  K +K I Q+ TS+M ++  V L  L        GAD+ A+C EA + AL       
Sbjct: 355 LPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKV 414

Query: 428 DNPVIDEIDFLEAFKNI 444
            N      DF ++ +N+
Sbjct: 415 TNE-----DFKKSKENV 426


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  175 bits (443), Expect = 2e-43
 Identities = 114/271 (42%), Positives = 152/271 (56%), Gaps = 22/271 (8%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GGLS    +L+E++  PL YP       +  PRG L  GPPG GKT + RA+A E    
Sbjct: 402 IGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQG 461

Query: 262 LLAVSAPALQGSR-----PGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRA 316
              V+    +G+       GE+E  +R +F +A  +    PS++F DE+D L P R SR 
Sbjct: 462 DKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMR---PSIIFFDEIDGLAPVRSSRQ 518

Query: 317 PE--SRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQR 374
            +  S +V+ +L L+DG     E+VV+GATNR D++DPALRRPGRFDRE +   P  K R
Sbjct: 519 DQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKAR 578

Query: 375 KEILQVITSKM-PISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL--------LHSEK 425
           K ILQ+ T    P  S   LG LAE  VGY GAD+ ALC EAA+ AL          S K
Sbjct: 579 KHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHK 638

Query: 426 NQ---DNPVIDEIDFLEAFKNIQPSSFRSVI 453
            Q    + V+   DF  A +NI P+S R+V+
Sbjct: 639 LQLDVSSIVLSAQDFYHAMQNIVPASQRAVM 669



 Score =  146 bits (368), Expect = 8e-35
 Identities = 94/253 (37%), Positives = 134/253 (52%), Gaps = 27/253 (10%)

Query: 459 KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRAL 518
           K V ++ IGGL      LK+ + +PL +P  F +  +  P+G L YGPPG  KT + RAL
Sbjct: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454

Query: 519 ATSC-----HCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGAR 573
           A  C       +F    GAD  S +VG+SE+ L  +F QA    P+I+F DEID +   R
Sbjct: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514

Query: 574 SASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDV 633
           S+ +    +   ++S LL  +DG     ++ RG               +++I ATNR D 
Sbjct: 515 SSRQD--QIHSSIVSTLLALMDG-----LDNRG--------------EIVVIGATNRLDS 553

Query: 634 LDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTM-PIGPDVSLENLAAETCFFSGADL 692
           +D AL RPGR D+      PD K R  IL++ T+   P   D  L  LA +   + GAD+
Sbjct: 554 IDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADI 613

Query: 693 RNLCTEAALLALQ 705
           + LCTEAAL+AL+
Sbjct: 614 KALCTEAALIALR 626


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  174 bits (441), Expect = 3e-43
 Identities = 104/286 (36%), Positives = 167/286 (58%), Gaps = 25/286 (8%)

Query: 444 IQPSSFRSVIGLM-DIKP-VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGV 501
           + P +  S++ L  D KP V + +IGG++  K ++++++E PL     + ++G+  P+GV
Sbjct: 139 LPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGV 198

Query: 502 LLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAIL 561
           L+YGPPGC KT L +A+A     +F+ V G++    ++G+  +++  +FR A+ + PAI+
Sbjct: 199 LMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAII 258

Query: 562 FLDEIDSILGARSASKTGCDVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNR 620
           F+DEID+I   R  ++TG D + +R+L  LLN++DG                 F +  N 
Sbjct: 259 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDG-----------------FDQ--NV 299

Query: 621 SVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENL 680
           +V +I ATNR D LD ALLRPGRLD+ I  P PD + +  I    T  M +  +V LE+ 
Sbjct: 300 NVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDY 359

Query: 681 AAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
            A     SGAD+ ++C E+ +LA++EN      V  + F K+ KTV
Sbjct: 360 VARPDKISGADINSICQESGMLAVREN---RYIVLAKDFEKAYKTV 402



 Score =  145 bits (366), Expect = 1e-34
 Identities = 88/248 (35%), Positives = 134/248 (54%), Gaps = 13/248 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GG+      +RE + LPL +      +G+  PRGVL+ GPPG GKT L +AVA    A 
Sbjct: 163 IGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAA 222

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR-----GSRA 316
            + V          GE    VR VF+ A+E A   P+++F+DE+DA+  +R     G+  
Sbjct: 223 FIRVVGSEFVQKYLGEGPRMVRDVFRLAKENA---PAIIFIDEIDAIATKRFDAQTGADR 279

Query: 317 PESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
              R++ ++L  +DG   +  V V+ ATNR D LDPAL RPGR DR++    P  +Q++ 
Sbjct: 280 EVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRL 339

Query: 377 ILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEID 436
           I   ITSKM +S  VDL           GAD+ ++C+E+ M A+      ++  ++   D
Sbjct: 340 IFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV-----RENRYIVLAKD 394

Query: 437 FLEAFKNI 444
           F +A+K +
Sbjct: 395 FEKAYKTV 402


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  174 bits (441), Expect = 3e-43
 Identities = 104/286 (36%), Positives = 167/286 (58%), Gaps = 25/286 (8%)

Query: 444 IQPSSFRSVIGLM-DIKP-VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGV 501
           + P +  S++ L  D KP V + +IGG++  K ++++++E PL     + ++G+  P+GV
Sbjct: 112 LPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGV 171

Query: 502 LLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAIL 561
           L+YGPPGC KT L +A+A     +F+ V G++    ++G+  +++  +FR A+ + PAI+
Sbjct: 172 LMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAII 231

Query: 562 FLDEIDSILGARSASKTGCDVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNR 620
           F+DEID+I   R  ++TG D + +R+L  LLN++DG                 F +  N 
Sbjct: 232 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDG-----------------FDQ--NV 272

Query: 621 SVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENL 680
           +V +I ATNR D LD ALLRPGRLD+ I  P PD + +  I    T  M +  +V LE+ 
Sbjct: 273 NVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDY 332

Query: 681 AAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
            A     SGAD+ ++C E+ +LA++EN      V  + F K+ KTV
Sbjct: 333 VARPDKISGADINSICQESGMLAVREN---RYIVLAKDFEKAYKTV 375



 Score =  145 bits (366), Expect = 1e-34
 Identities = 88/248 (35%), Positives = 134/248 (54%), Gaps = 13/248 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GG+      +RE + LPL +      +G+  PRGVL+ GPPG GKT L +AVA    A 
Sbjct: 136 IGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAA 195

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR-----GSRA 316
            + V          GE    VR VF+ A+E A   P+++F+DE+DA+  +R     G+  
Sbjct: 196 FIRVVGSEFVQKYLGEGPRMVRDVFRLAKENA---PAIIFIDEIDAIATKRFDAQTGADR 252

Query: 317 PESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
              R++ ++L  +DG   +  V V+ ATNR D LDPAL RPGR DR++    P  +Q++ 
Sbjct: 253 EVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRL 312

Query: 377 ILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEID 436
           I   ITSKM +S  VDL           GAD+ ++C+E+ M A+      ++  ++   D
Sbjct: 313 IFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV-----RENRYIVLAKD 367

Query: 437 FLEAFKNI 444
           F +A+K +
Sbjct: 368 FEKAYKTV 375


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  174 bits (441), Expect = 3e-43
 Identities = 104/286 (36%), Positives = 167/286 (58%), Gaps = 25/286 (8%)

Query: 444 IQPSSFRSVIGLM-DIKP-VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGV 501
           + P +  S++ L  D KP V + +IGG++  K ++++++E PL     + ++G+  P+GV
Sbjct: 143 LPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGV 202

Query: 502 LLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAIL 561
           L+YGPPGC KT L +A+A     +F+ V G++    ++G+  +++  +FR A+ + PAI+
Sbjct: 203 LMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAII 262

Query: 562 FLDEIDSILGARSASKTGCDVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNR 620
           F+DEID+I   R  ++TG D + +R+L  LLN++DG                 F +  N 
Sbjct: 263 FIDEIDAIATKRFDAQTGADREVQRILLELLNQMDG-----------------FDQ--NV 303

Query: 621 SVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENL 680
           +V +I ATNR D LD ALLRPGRLD+ I  P PD + +  I    T  M +  +V LE+ 
Sbjct: 304 NVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDY 363

Query: 681 AAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
            A     SGAD+ ++C E+ +LA++EN      V  + F K+ KTV
Sbjct: 364 VARPDKISGADINSICQESGMLAVREN---RYIVLAKDFEKAYKTV 406



 Score =  145 bits (366), Expect = 1e-34
 Identities = 88/248 (35%), Positives = 134/248 (54%), Gaps = 13/248 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GG+      +RE + LPL +      +G+  PRGVL+ GPPG GKT L +AVA    A 
Sbjct: 167 IGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAA 226

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR-----GSRA 316
            + V          GE    VR VF+ A+E A   P+++F+DE+DA+  +R     G+  
Sbjct: 227 FIRVVGSEFVQKYLGEGPRMVRDVFRLAKENA---PAIIFIDEIDAIATKRFDAQTGADR 283

Query: 317 PESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
              R++ ++L  +DG   +  V V+ ATNR D LDPAL RPGR DR++    P  +Q++ 
Sbjct: 284 EVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRL 343

Query: 377 ILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEID 436
           I   ITSKM +S  VDL           GAD+ ++C+E+ M A+      ++  ++   D
Sbjct: 344 IFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV-----RENRYIVLAKD 398

Query: 437 FLEAFKNI 444
           F +A+K +
Sbjct: 399 FEKAYKTV 406


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  168 bits (425), Expect = 2e-41
 Identities = 101/286 (35%), Positives = 160/286 (55%), Gaps = 26/286 (9%)

Query: 446 PSSFRSVIGLMDI--KPVD-WEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502
           P+ + S +  M++  +P + + +IGGL+    +L ++I  P+    +F  +G+  PKGVL
Sbjct: 165 PTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVL 224

Query: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562
           +YGPPG  KT L RA A     +F+ ++G  L   F+GD  K++   F  A+   P+I+F
Sbjct: 225 MYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIF 284

Query: 563 LDEIDSILGAR-SASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRS 621
           +DE+D+I   R  + K G    +R +  LLN+LDG                 FQ   N  
Sbjct: 285 IDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDG-----------------FQP--NTQ 325

Query: 622 VMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLA 681
           V +IAATNR D+LD ALLR GRLD+ I  P P+ + R  I+++ ++ M + PDV+ E LA
Sbjct: 326 VKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELA 385

Query: 682 AETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVK 727
             T  F+GA  + +C EA ++AL+     AT +  E +++ +  V+
Sbjct: 386 RCTDDFNGAQCKAVCVEAGMIALRRG---ATELTHEDYMEGILEVQ 428



 Score =  139 bits (349), Expect = 1e-32
 Identities = 87/225 (38%), Positives = 124/225 (55%), Gaps = 10/225 (4%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GGL +    L E + LP+ +      LG+  P+GVL+ GPPG GKT L RA A +  A 
Sbjct: 188 IGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKAT 247

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR------GSR 315
            L ++ P L     G+  + VR  F  A+E A   PS++F+DE+DA+  +R      G R
Sbjct: 248 FLKLAGPQLVQMFIGDGAKLVRDAFALAKEKA---PSIIFIDELDAIGTKRFDSEKAGDR 304

Query: 316 APESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRK 375
             + R + ++L  LDG   + +V V+ ATNR D LDPAL R GR DR++    P  + R 
Sbjct: 305 EVQ-RTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363

Query: 376 EILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
            I+Q+ + KM +S  V+   LA  T  + GA   A+C EA M AL
Sbjct: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  168 bits (425), Expect = 2e-41
 Identities = 108/294 (36%), Positives = 166/294 (56%), Gaps = 32/294 (10%)

Query: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519
           + W++I  LE+ K  L++++  P+  P  F   G+ +P KGVL+ GPPG  KT L +A+A
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLMVGPPGTGKTMLAKAVA 262

Query: 520 TSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTG 579
           T C  +F +VS + L S + G+SEK++  +F  AR   P  +F+DEIDSI   R  S   
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322

Query: 580 CDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639
            +   RV S LL ++DGVG       G+  +        ++ VM++AATN P  +D AL 
Sbjct: 323 -EASRRVKSELLIQMDGVG-------GALENDDP-----SKMVMVLAATNFPWDIDEALR 369

Query: 640 RPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEA 699
           R  RL+K IYIP P  KGR  +LK+  + + + PD+ LE++A +   +SGAD+ N+C +A
Sbjct: 370 R--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDA 427

Query: 700 ALLALQE--NGLDATTVK------------QEHFLKSLKTVKPSLSCKDLALYE 739
           +L+A++   NGL    ++            +  F  +LK +  S+S  DL  YE
Sbjct: 428 SLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYE 481



 Score =  134 bits (336), Expect = 4e-31
 Identities = 86/230 (37%), Positives = 130/230 (56%), Gaps = 18/230 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREAGA 260
           +  L EA   LRE + LP+  P      G+  P +GVL+ GPPG GKT L +AVA E G 
Sbjct: 210 IADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVATECGT 267

Query: 261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS---RAP 317
               VS+  L     GE+E+ VR +F+ AR  A   P+ +F+DE+D++C +RG+      
Sbjct: 268 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA---PTTIFIDEIDSICSRRGTSDEHEA 324

Query: 318 ESRVVAQVLTLLDGASGDRE-------VVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370
             RV +++L  +DG  G  E       V+V+ ATN P  +D ALRR  R ++ + I  PT
Sbjct: 325 SRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPT 382

Query: 371 LKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
            K R E+L++   ++ +   + L  +AE   GY GAD+T +CR+A++ A+
Sbjct: 383 AKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAM 432


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  168 bits (425), Expect = 2e-41
 Identities = 108/294 (36%), Positives = 166/294 (56%), Gaps = 32/294 (10%)

Query: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519
           + W++I  LE+ K  L++++  P+  P  F   G+ +P KGVL+ GPPG  KT L +A+A
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLMVGPPGTGKTMLAKAVA 262

Query: 520 TSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTG 579
           T C  +F +VS + L S + G+SEK++  +F  AR   P  +F+DEIDSI   R  S   
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322

Query: 580 CDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639
            +   RV S LL ++DGVG       G+  +        ++ VM++AATN P  +D AL 
Sbjct: 323 -EASRRVKSELLIQMDGVG-------GALENDDP-----SKMVMVLAATNFPWDIDEALR 369

Query: 640 RPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEA 699
           R  RL+K IYIP P  KGR  +LK+  + + + PD+ LE++A +   +SGAD+ N+C +A
Sbjct: 370 R--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDA 427

Query: 700 ALLALQE--NGLDATTVK------------QEHFLKSLKTVKPSLSCKDLALYE 739
           +L+A++   NGL    ++            +  F  +LK +  S+S  DL  YE
Sbjct: 428 SLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYE 481



 Score =  134 bits (336), Expect = 4e-31
 Identities = 86/230 (37%), Positives = 130/230 (56%), Gaps = 18/230 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREAGA 260
           +  L EA   LRE + LP+  P      G+  P +GVL+ GPPG GKT L +AVA E G 
Sbjct: 210 IADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVATECGT 267

Query: 261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS---RAP 317
               VS+  L     GE+E+ VR +F+ AR  A   P+ +F+DE+D++C +RG+      
Sbjct: 268 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA---PTTIFIDEIDSICSRRGTSDEHEA 324

Query: 318 ESRVVAQVLTLLDGASGDRE-------VVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370
             RV +++L  +DG  G  E       V+V+ ATN P  +D ALRR  R ++ + I  PT
Sbjct: 325 SRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPT 382

Query: 371 LKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
            K R E+L++   ++ +   + L  +AE   GY GAD+T +CR+A++ A+
Sbjct: 383 AKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAM 432


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  168 bits (425), Expect = 2e-41
 Identities = 100/285 (35%), Positives = 159/285 (55%), Gaps = 26/285 (9%)

Query: 446 PSSFRSVIGLMDI--KP-VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502
           P      + +M +  KP V + ++GG ++   KL++ +E PL  P  FV +G+  PKGVL
Sbjct: 154 PPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVL 213

Query: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562
           L+GPPG  KT   RA+A      F+ V G++L   +VG+  +++ ++F  AR     ++F
Sbjct: 214 LFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIF 273

Query: 563 LDEIDSILGARSASKTGCDVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRS 621
            DEID+I GAR     G D + +R +  L+N+LDG      + RG              +
Sbjct: 274 FDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDG-----FDPRG--------------N 314

Query: 622 VMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLA 681
           + ++ ATNRPD LD AL+RPGRLD+ I    PD +GR  I K+  ++M +  D+  E LA
Sbjct: 315 IKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLA 374

Query: 682 AETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
                 +GA++R++CTEA + A++     AT   ++ FL+++  V
Sbjct: 375 RLCPNSTGAEIRSVCTEAGMFAIRARRKIAT---EKDFLEAVNKV 416



 Score =  145 bits (367), Expect = 1e-34
 Identities = 91/260 (35%), Positives = 131/260 (50%), Gaps = 16/260 (6%)

Query: 193 EAQPQPEVP---LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQ 249
           + + +P+V    +GG  E  + LRE++  PL +P     LG+  P+GVLL GPPG GKT 
Sbjct: 165 QVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTL 224

Query: 250 LVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALC 309
             RAVA    A  + V    L     GE    VR +F+ AR   ++   L+F DE+DA+ 
Sbjct: 225 CARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMAR---TKKACLIFFDEIDAIG 281

Query: 310 PQR-----GSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREV 364
             R     G      R + +++  LDG      + V+ ATNRPD LDPAL RPGR DR++
Sbjct: 282 GARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKI 341

Query: 365 VIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSE 424
               P L+ R  I ++    M +   +   LLA +     GA++ ++C EA M A+    
Sbjct: 342 EFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARR 401

Query: 425 KNQDNPVIDEIDFLEAFKNI 444
           K     +  E DFLEA   +
Sbjct: 402 K-----IATEKDFLEAVNKV 416


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  166 bits (421), Expect = 6e-41
 Identities = 119/348 (34%), Positives = 184/348 (52%), Gaps = 39/348 (11%)

Query: 412 CREAAMHALLHSEKNQD-----NPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEI 466
           CRE         EKN+       P  ++ D     K++  +  R +I       V W++I
Sbjct: 154 CREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIIS--QNPNVRWDDI 211

Query: 467 GGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALATSCHCS 525
             L + K  LK+++  P+  P EF + G+ +P KGVL+ GPPG  KT L +A+AT C  +
Sbjct: 212 ADLVEAKKLLKEAVVLPMWMP-EFFK-GIRRPWKGVLMVGPPGTGKTLLAKAVATECKTT 269

Query: 526 FVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQER 585
           F +VS + L S + G+SEK++  +F  AR  +PA +F+DEIDSI   R  S+   +   R
Sbjct: 270 FFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEH-EASRR 328

Query: 586 VLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLD 645
           V + LL ++DGVG       G+  +        ++ VM++AATN P  +D AL R  RL+
Sbjct: 329 VKAELLVQMDGVG-------GTSENDDP-----SKMVMVLAATNFPWDIDEALRR--RLE 374

Query: 646 KIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQ 705
           K IYIP P  KGR  +L++  + + +  DV L ++A     +SGAD+ N+C +A+L+A++
Sbjct: 375 KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434

Query: 706 E--NGLDATTVK------------QEHFLKSLKTVKPSLSCKDLALYE 739
               GL    ++             E F  +LK V  S+S  D+  YE
Sbjct: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYE 482



 Score =  134 bits (338), Expect = 2e-31
 Identities = 85/230 (36%), Positives = 132/230 (57%), Gaps = 18/230 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREAGA 260
           +  L EA   L+E + LP+  P      G+  P +GVL+ GPPG GKT L +AVA E   
Sbjct: 211 IADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVATECKT 268

Query: 261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS---RAP 317
               VS+  L     GE+E+ VR +F+ AR  +   P+ +F+DE+D++C +RG+      
Sbjct: 269 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYS---PATIFIDEIDSICSRRGTSEEHEA 325

Query: 318 ESRVVAQVLTLLDGASGDRE-------VVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370
             RV A++L  +DG  G  E       V+V+ ATN P  +D ALRR  R ++ + I  P+
Sbjct: 326 SRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPS 383

Query: 371 LKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
            K R+E+L++   ++ ++  VDL  +AE   GY GAD+T +CR+A++ A+
Sbjct: 384 AKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  166 bits (420), Expect = 7e-41
 Identities = 109/290 (37%), Positives = 159/290 (54%), Gaps = 32/290 (11%)

Query: 455 LMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTL 514
           L D   V ++++ G E+ KL++ + + + LK P ++  +G   PKG +L GPPG  KT L
Sbjct: 299 LKDEIDVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLL 357

Query: 515 VRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARS 574
            +A A   +  F++VSG++    FVG     +  +F  AR + P ILF+DEID++   R 
Sbjct: 358 AKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRG 417

Query: 575 ASK-TGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDV 633
                G   QE  L+ LL E+DG    T                   +V+I+A TNRPD+
Sbjct: 418 RGNFGGQSEQENTLNQLLVEMDGFNTTT-------------------NVVILAGTNRPDI 458

Query: 634 LDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLE------NLAAETCFF 687
           LD ALLRPGR D+ I+I PPD KGR SI KV  +  P+  D +LE       LA+ T  F
Sbjct: 459 LDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLR--PLKLDSTLEKDKLARKLASLTPGF 516

Query: 688 SGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVKPSLSCKDLAL 737
           SGAD+ N+C EAAL+A +     + ++ Q+HF ++++ V   L  K   L
Sbjct: 517 SGADVANVCNEAALIAARHL---SDSINQKHFEQAIERVIGGLEKKTQVL 563



 Score =  139 bits (351), Expect = 7e-33
 Identities = 85/230 (36%), Positives = 124/230 (53%), Gaps = 13/230 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           + G  EA   + E +   L+ P+    LG  +P+G +L GPPG GKT L +A A EA   
Sbjct: 310 VAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVP 368

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRG-----SRA 316
            + VS         G     VR +F  AR+ A   P +LF+DE+DA+  +RG      ++
Sbjct: 369 FITVSGSEFLEMFVGVGPARVRDLFALARKNA---PCILFIDEIDAVGRKRGRGNFGGQS 425

Query: 317 PESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
            +   + Q+L  +DG +    VV++  TNRPD LDPAL RPGRFDR++ IG P +K R  
Sbjct: 426 EQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRAS 485

Query: 377 ILQVITSKMPISSHVD----LGLLAEMTVGYVGADLTALCREAAMHALLH 422
           I +V    + + S ++       LA +T G+ GAD+  +C EAA+ A  H
Sbjct: 486 IFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARH 535


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  162 bits (410), Expect = 1e-39
 Identities = 108/270 (40%), Positives = 150/270 (55%), Gaps = 22/270 (8%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           +GGLS    +L+E++  PL YP       +  PRG L  GPPG GKT + RA+A E    
Sbjct: 428 VGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQG 487

Query: 262 LLAVSAPALQGSR-----PGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRA 316
              V+    +G+       GE+E  +R +F +A ++    PS++F DE+D L P R SR 
Sbjct: 488 DKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMR---PSIIFFDEIDGLAPVRSSRQ 544

Query: 317 PE--SRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQR 374
            +  S +V+ +L L+DG     E+VV+GATNR D++DPALRRPGRFDRE +   P  + R
Sbjct: 545 DQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEAR 604

Query: 375 KEILQVITSKM-PISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLH--------SEK 425
           KEIL++ T    P      L  LAE  VGY GAD+ ++C EAA+ AL          SEK
Sbjct: 605 KEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEK 664

Query: 426 NQ---DNPVIDEIDFLEAFKNIQPSSFRSV 452
            Q    +  I   DF  A + + P+S R+V
Sbjct: 665 LQLDLSSINISAKDFEVAMQKMIPASQRAV 694



 Score =  148 bits (373), Expect = 2e-35
 Identities = 96/279 (34%), Positives = 141/279 (50%), Gaps = 33/279 (11%)

Query: 439 EAFKNIQPSSFRSVIGLMDIKP------VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVR 492
           +  K I     +    L D+ P      V ++ +GGL +    LK+ + +PL +P  F +
Sbjct: 395 DELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454

Query: 493 MGLTQPKGVLLYGPPGCAKTTLVRALATSC-----HCSFVSVSGADLFSPFVGDSEKVLS 547
             +  P+G L YGPPG  KT + RALA  C       +F    GAD  S +VG+SE+ L 
Sbjct: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514

Query: 548 QIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGS 607
            +F QA    P+I+F DEID +   RS+ +    +   ++S LL  +DG     ++ RG 
Sbjct: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQD--QIHSSIVSTLLALMDG-----LDSRG- 566

Query: 608 KSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTK 667
                         +++I ATNR D +D AL RPGR D+      PD + R  ILK+ T+
Sbjct: 567 -------------EIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTR 613

Query: 668 TMPIGP-DVSLENLAAETCFFSGADLRNLCTEAALLALQ 705
                P D  LE LA     + GAD++++C EAAL AL+
Sbjct: 614 DWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALR 652


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  160 bits (406), Expect = 3e-39
 Identities = 105/320 (32%), Positives = 168/320 (52%), Gaps = 34/320 (10%)

Query: 439 EAFKNIQPSSFRSVIG-LMDI-KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLT 496
           E  KN++P     ++  +MD   PV+WE+I G+E  K  +K+ + WP+  P  F  +   
Sbjct: 374 ERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-G 432

Query: 497 QPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARAS 556
            PKG+LL+GPPG  KT + + +A+    +F S+S + L S +VG+ EK++  +F  AR  
Sbjct: 433 PPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQ 492

Query: 557 TPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQE 616
            PA++F+DEIDS+L  R   +   +   R+ +  L +LDG    + +R            
Sbjct: 493 QPAVIFIDEIDSLLSQRGDGEH--ESSRRIKTEFLVQLDGATTSSEDR------------ 538

Query: 617 VFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSI-LKVCTKTMPIGPDV 675
                ++++ ATNRP  +D A  R  RL K +YIP P+   R  I + + +K      + 
Sbjct: 539 -----ILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQIVINLMSKEQCCLSEE 591

Query: 676 SLENLAAETCFFSGADLRNLCTEAALLALQE-NGLDATTVKQEH--------FLKSLKTV 726
            +E +  ++  FSGAD+  LC EA+L  ++     D  T+  +         F  + +TV
Sbjct: 592 EIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTV 651

Query: 727 KPSLSCKDLALYENLFKKEG 746
           +PS+S KDL LYEN  K  G
Sbjct: 652 RPSVSPKDLELYENWNKTFG 671



 Score =  131 bits (329), Expect = 3e-30
 Identities = 88/259 (33%), Positives = 144/259 (55%), Gaps = 20/259 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           + G+  A  +++E++  P+  P   T L    P+G+LL GPPG GKT + + +A ++GA 
Sbjct: 403 IAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIASQSGAT 461

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES-- 319
             ++SA +L     GE E+ VR +F  AR    + P+++F+DE+D+L  QRG    ES  
Sbjct: 462 FFSISASSLTSKWVGEGEKMVRALFAVAR---CQQPAVIFIDEIDSLLSQRGDGEHESSR 518

Query: 320 RVVAQVLTLLDGA--SGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEI 377
           R+  + L  LDGA  S +  ++VVGATNRP  +D A RR  R  + + I  P    RK+I
Sbjct: 519 RIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQI 576

Query: 378 -LQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSE--------KNQD 428
            + +++ +    S  ++  + + +  + GAD+T LCREA++  +   +         +Q 
Sbjct: 577 VINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQV 636

Query: 429 NPVIDEIDFLEAFKNIQPS 447
            P I  IDF  AF+ ++PS
Sbjct: 637 RP-IAYIDFENAFRTVRPS 654


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  160 bits (406), Expect = 3e-39
 Identities = 105/320 (32%), Positives = 168/320 (52%), Gaps = 34/320 (10%)

Query: 439 EAFKNIQPSSFRSVIG-LMDI-KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLT 496
           E  KN++P     ++  +MD   PV+WE+I G+E  K  +K+ + WP+  P  F  +   
Sbjct: 374 ERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-G 432

Query: 497 QPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARAS 556
            PKG+LL+GPPG  KT + + +A+    +F S+S + L S +VG+ EK++  +F  AR  
Sbjct: 433 PPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQ 492

Query: 557 TPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQE 616
            PA++F+DEIDS+L  R   +   +   R+ +  L +LDG    + +R            
Sbjct: 493 QPAVIFIDEIDSLLSQRGDGEH--ESSRRIKTEFLVQLDGATTSSEDR------------ 538

Query: 617 VFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSI-LKVCTKTMPIGPDV 675
                ++++ ATNRP  +D A  R  RL K +YIP P+   R  I + + +K      + 
Sbjct: 539 -----ILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQIVINLMSKEQCCLSEE 591

Query: 676 SLENLAAETCFFSGADLRNLCTEAALLALQE-NGLDATTVKQEH--------FLKSLKTV 726
            +E +  ++  FSGAD+  LC EA+L  ++     D  T+  +         F  + +TV
Sbjct: 592 EIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTV 651

Query: 727 KPSLSCKDLALYENLFKKEG 746
           +PS+S KDL LYEN  K  G
Sbjct: 652 RPSVSPKDLELYENWNKTFG 671



 Score =  131 bits (329), Expect = 3e-30
 Identities = 88/259 (33%), Positives = 144/259 (55%), Gaps = 20/259 (7%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           + G+  A  +++E++  P+  P   T L    P+G+LL GPPG GKT + + +A ++GA 
Sbjct: 403 IAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIASQSGAT 461

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES-- 319
             ++SA +L     GE E+ VR +F  AR    + P+++F+DE+D+L  QRG    ES  
Sbjct: 462 FFSISASSLTSKWVGEGEKMVRALFAVAR---CQQPAVIFIDEIDSLLSQRGDGEHESSR 518

Query: 320 RVVAQVLTLLDGA--SGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEI 377
           R+  + L  LDGA  S +  ++VVGATNRP  +D A RR  R  + + I  P    RK+I
Sbjct: 519 RIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQI 576

Query: 378 -LQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSE--------KNQD 428
            + +++ +    S  ++  + + +  + GAD+T LCREA++  +   +         +Q 
Sbjct: 577 VINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQV 636

Query: 429 NPVIDEIDFLEAFKNIQPS 447
            P I  IDF  AF+ ++PS
Sbjct: 637 RP-IAYIDFENAFRTVRPS 654


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  157 bits (396), Expect = 4e-38
 Identities = 103/279 (36%), Positives = 149/279 (53%), Gaps = 28/279 (10%)

Query: 449 FRSVIGL------MDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502
           FR+  GL      + +K V +E + G+E+ K +L++ +E+ LK P +F  +G   PKG+L
Sbjct: 318 FRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGIL 376

Query: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562
           L GPPG  KT L RA+A      F   SG++    FVG     +  +FR+A+A+ P ++F
Sbjct: 377 LVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIF 436

Query: 563 LDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSV 622
           +DE+DS+ G R  S        + ++ LL E+DG                 F+   N  V
Sbjct: 437 IDELDSVGGKRIESPMH-PYSRQTINQLLAEMDG-----------------FKP--NEGV 476

Query: 623 MIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAA 682
           +II ATN P+ LD AL+RPGR D  + +P PD KGR  ILK     +     V  E +A 
Sbjct: 477 IIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIAR 536

Query: 683 ETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLK 721
            T  FSGA+L NL  +AAL A  + G +  T+K+  F K
Sbjct: 537 GTVGFSGAELENLVNQAALKAAVD-GKEMVTMKELEFSK 574



 Score =  140 bits (354), Expect = 3e-33
 Identities = 85/225 (37%), Positives = 127/225 (56%), Gaps = 7/225 (3%)

Query: 204 GLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELL 263
           G+ EA   L+E++   L+ P+  T LG  +P+G+LL GPPG GKT L RAVA EA     
Sbjct: 343 GVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFY 401

Query: 264 AVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESR- 320
             S         G     +R +F   RE  +  P ++F+DE+D++  +R      P SR 
Sbjct: 402 YASGSEFDEMFVGVGASRIRNLF---REAKANAPCVIFIDELDSVGGKRIESPMHPYSRQ 458

Query: 321 VVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQV 380
            + Q+L  +DG   +  V+++GATN P+ALD AL RPGRFD +V +  P +K R EIL+ 
Sbjct: 459 TINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKW 518

Query: 381 ITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEK 425
             +K+     VD  ++A  TVG+ GA+L  L  +AA+ A +  ++
Sbjct: 519 YLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKE 563


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  157 bits (396), Expect = 4e-38
 Identities = 103/279 (36%), Positives = 149/279 (53%), Gaps = 28/279 (10%)

Query: 449 FRSVIGL------MDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502
           FR+  GL      + +K V +E + G+E+ K +L++ +E+ LK P +F  +G   PKG+L
Sbjct: 261 FRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGIL 319

Query: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562
           L GPPG  KT L RA+A      F   SG++    FVG     +  +FR+A+A+ P ++F
Sbjct: 320 LVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIF 379

Query: 563 LDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSV 622
           +DE+DS+ G R  S        + ++ LL E+DG                 F+   N  V
Sbjct: 380 IDELDSVGGKRIESPMH-PYSRQTINQLLAEMDG-----------------FKP--NEGV 419

Query: 623 MIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAA 682
           +II ATN P+ LD AL+RPGR D  + +P PD KGR  ILK     +     V  E +A 
Sbjct: 420 IIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIAR 479

Query: 683 ETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLK 721
            T  FSGA+L NL  +AAL A  + G +  T+K+  F K
Sbjct: 480 GTVGFSGAELENLVNQAALKAAVD-GKEMVTMKELEFSK 517



 Score =  140 bits (354), Expect = 3e-33
 Identities = 85/225 (37%), Positives = 127/225 (56%), Gaps = 7/225 (3%)

Query: 204 GLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELL 263
           G+ EA   L+E++   L+ P+  T LG  +P+G+LL GPPG GKT L RAVA EA     
Sbjct: 286 GVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFY 344

Query: 264 AVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESR- 320
             S         G     +R +F   RE  +  P ++F+DE+D++  +R      P SR 
Sbjct: 345 YASGSEFDEMFVGVGASRIRNLF---REAKANAPCVIFIDELDSVGGKRIESPMHPYSRQ 401

Query: 321 VVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQV 380
            + Q+L  +DG   +  V+++GATN P+ALD AL RPGRFD +V +  P +K R EIL+ 
Sbjct: 402 TINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKW 461

Query: 381 ITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEK 425
             +K+     VD  ++A  TVG+ GA+L  L  +AA+ A +  ++
Sbjct: 462 YLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKE 506


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  156 bits (395), Expect = 6e-38
 Identities = 95/283 (33%), Positives = 158/283 (55%), Gaps = 25/283 (8%)

Query: 440 AFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPK 499
           AF  ++ + F  V G M  K V ++++ G+ + KL++++ +++ LK P  F+++G   PK
Sbjct: 286 AFNQLKMARFTIVDGKMG-KGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPK 343

Query: 500 GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPA 559
           G LL GPPGC KT L +A+AT     F++++G +      G     +  +F++ARA  P 
Sbjct: 344 GALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPC 403

Query: 560 ILFLDEIDSILGARSASKTGCD--VQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEV 617
           I+++DEID++   RS + +G     +E+ L+ LL E+DG+G                   
Sbjct: 404 IVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGT------------------ 445

Query: 618 FNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSL 677
               V+++A+TNR D+LD AL+RPGRLD+ ++I  P  + R  I +   K++ +    + 
Sbjct: 446 -TDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTF 504

Query: 678 --ENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEH 718
             + LA  T  FSGAD+ N+C EAAL A +E      T+  E+
Sbjct: 505 YSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEY 547



 Score =  145 bits (365), Expect = 2e-34
 Identities = 90/226 (39%), Positives = 128/226 (56%), Gaps = 12/226 (5%)

Query: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
           + G+ EA   +RE +   L+ P     LG  VP+G LL GPPG GKT L +AVA EA   
Sbjct: 311 VAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVP 369

Query: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRG------SR 315
            LA++ P       G     VR +F+ AR   +R P ++++DE+DA+  +R       S 
Sbjct: 370 FLAMAGPEFVEVIGGLGAARVRSLFKEAR---ARAPCIVYIDEIDAVGKKRSTTMSGFSN 426

Query: 316 APESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRK 375
             E + + Q+L  +DG      V+V+ +TNR D LD AL RPGR DR V I  PTL++R+
Sbjct: 427 TEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERR 486

Query: 376 EILQ--VITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHA 419
           EI +  + + K+  SS      LAE+T G+ GAD+  +C EAA+HA
Sbjct: 487 EIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532


>gi|156564401 vesicle-fusing ATPase [Homo sapiens]
          Length = 744

 Score =  147 bits (370), Expect = 5e-35
 Identities = 137/464 (29%), Positives = 212/464 (45%), Gaps = 62/464 (13%)

Query: 202 LGGLS-EAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGA 260
           +GGL  E +D  R      +  P  +  +G    +G+LL GPPG GKT L R + +   A
Sbjct: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279

Query: 261 -ELLAVSAPALQGSRPGETEENVRRVFQRAREL-----ASRGPSLLFLDEMDALCPQRGS 314
            E   V+ P +     GE+E N+R++F  A E      A+ G  ++  DE+DA+C QRGS
Sbjct: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339

Query: 315 RAPES----RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370
            A  +     VV Q+L+ +DG      ++V+G TNRPD +D AL RPGR + ++ IG P 
Sbjct: 340 MAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPD 399

Query: 371 LKQRKEILQVITSKMP----ISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKN 426
            K R +IL + T++M     +S+ VD+  LA  T  + GA+L  L R A   A+    K 
Sbjct: 400 EKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459

Query: 427 QDNPVIDEIDFLEAFKNIQPSSFRSVIGL-MDIKPVDWEEIGGLEDVKLKLKQS-IEW-- 482
                +D    +E  +++Q +    +  L  DIKP         ED    +    I+W  
Sbjct: 460 STKVEVD----MEKAESLQVTRGDFLASLENDIKPAFGT---NQEDYASYIMNGIIKWGD 512

Query: 483 PLKFPWEFVRMGLTQPK--------GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADL 534
           P+    +   + + Q K         VLL GPP   KT L   +A   +  F+ +   D 
Sbjct: 513 PVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD- 571

Query: 535 FSPFVGDSE----KVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVL 590
               +G SE    + + +IF  A  S  + + +D+I+ +L          ++  + L VL
Sbjct: 572 --KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVL 629

Query: 591 LNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVL 634
           L +    G                     R ++II  T+R DVL
Sbjct: 630 LKKAPPQG---------------------RKLLIIGTTSRKDVL 652



 Score =  124 bits (310), Expect = 4e-28
 Identities = 87/244 (35%), Positives = 126/244 (51%), Gaps = 33/244 (13%)

Query: 486 FPWEFV-RMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSV-SGADLFSPFVGDSE 543
           FP E V +MG    KG+LLYGPPGC KT L R +    +     V +G ++ + +VG+SE
Sbjct: 240 FPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESE 299

Query: 544 KVLSQIFRQARA--------STPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELD 595
             + ++F  A          S   I+  DEID+I   R +      V + V++ LL+++D
Sbjct: 300 ANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKID 359

Query: 596 GVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDH 655
           GV                  E  N ++++I  TNRPD++D ALLRPGRL+  + I  PD 
Sbjct: 360 GV------------------EQLN-NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDE 400

Query: 656 KGRLSILKVCTKTMP----IGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDA 711
           KGRL IL + T  M     +  DV ++ LA ET  FSGA+L  L   A   A+  +   +
Sbjct: 401 KGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460

Query: 712 TTVK 715
           T V+
Sbjct: 461 TKVE 464


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  144 bits (362), Expect = 4e-34
 Identities = 92/263 (34%), Positives = 144/263 (54%), Gaps = 39/263 (14%)

Query: 467 GGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSF 526
           GGL++   ++K+S+E PL  P  +  MG   PKGV+L GPPG A              +F
Sbjct: 175 GGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TF 220

Query: 527 VSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCD--VQE 584
           + V G++L   ++GD  K++ Q+F+ A    P+I+F DEI++I   R  S +G +  +Q+
Sbjct: 221 LRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQ 280

Query: 585 RVLSV-LLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGR 643
            +L + LLN+L G   +                     V +I AT + + LD  L+RPGR
Sbjct: 281 TMLELELLNQLGGFDSR-------------------EDVKVIMATKQVETLDPVLIRPGR 321

Query: 644 LDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLA 703
           +DK I    PD K +  I ++ T  M +  DV+L++L      FSGAD++ +CTEA L+A
Sbjct: 322 IDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMA 381

Query: 704 LQENGLDATTVKQEHFLKSLKTV 726
           L+E+ + AT    E F KS+++V
Sbjct: 382 LREHRMKAT---NEDFKKSIESV 401



 Score =  112 bits (281), Expect = 1e-24
 Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 24/235 (10%)

Query: 193 EAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVR 252
           +A  +  V  GGL      ++E + LPL +P     +G   P+GV+L GPPG        
Sbjct: 165 KAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA------ 218

Query: 253 AVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR 312
              R  G+EL+            G+  + VR+VFQ A E A   PS++F DE++A+  +R
Sbjct: 219 TFLRVVGSELIQKYL--------GDGPKLVRQVFQVAEEHA---PSIMFTDEIEAIGTKR 267

Query: 313 ------GSRAPESRVVA-QVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVV 365
                 G R  +  ++  ++L  L G     +V V+ AT + + LDP L RPGR D+++ 
Sbjct: 268 YDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIE 327

Query: 366 IGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
              P  K +K I Q+ TS+M +++ V L  L      + GAD+ A+C EA + AL
Sbjct: 328 FHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMAL 382


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  144 bits (362), Expect = 4e-34
 Identities = 92/263 (34%), Positives = 144/263 (54%), Gaps = 39/263 (14%)

Query: 467 GGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSF 526
           GGL++   ++K+S+E PL  P  +  MG   PKGV+L GPPG A              +F
Sbjct: 175 GGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TF 220

Query: 527 VSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCD--VQE 584
           + V G++L   ++GD  K++ Q+F+ A    P+I+F DEI++I   R  S +G +  +Q+
Sbjct: 221 LRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQ 280

Query: 585 RVLSV-LLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGR 643
            +L + LLN+L G   +                     V +I AT + + LD  L+RPGR
Sbjct: 281 TMLELELLNQLGGFDSR-------------------EDVKVIMATKQVETLDPVLIRPGR 321

Query: 644 LDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLA 703
           +DK I    PD K +  I ++ T  M +  DV+L++L      FSGAD++ +CTEA L+A
Sbjct: 322 IDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMA 381

Query: 704 LQENGLDATTVKQEHFLKSLKTV 726
           L+E+ + AT    E F KS+++V
Sbjct: 382 LREHRMKAT---NEDFKKSIESV 401



 Score =  112 bits (281), Expect = 1e-24
 Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 24/235 (10%)

Query: 193 EAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVR 252
           +A  +  V  GGL      ++E + LPL +P     +G   P+GV+L GPPG        
Sbjct: 165 KAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA------ 218

Query: 253 AVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR 312
              R  G+EL+            G+  + VR+VFQ A E A   PS++F DE++A+  +R
Sbjct: 219 TFLRVVGSELIQKYL--------GDGPKLVRQVFQVAEEHA---PSIMFTDEIEAIGTKR 267

Query: 313 ------GSRAPESRVVA-QVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVV 365
                 G R  +  ++  ++L  L G     +V V+ AT + + LDP L RPGR D+++ 
Sbjct: 268 YDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIE 327

Query: 366 IGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
              P  K +K I Q+ TS+M +++ V L  L      + GAD+ A+C EA + AL
Sbjct: 328 FHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMAL 382


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  144 bits (362), Expect = 4e-34
 Identities = 92/263 (34%), Positives = 144/263 (54%), Gaps = 39/263 (14%)

Query: 467 GGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSF 526
           GGL++   ++K+S+E PL  P  +  MG   PKGV+L GPPG A              +F
Sbjct: 175 GGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TF 220

Query: 527 VSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCD--VQE 584
           + V G++L   ++GD  K++ Q+F+ A    P+I+F DEI++I   R  S +G +  +Q+
Sbjct: 221 LRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQ 280

Query: 585 RVLSV-LLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGR 643
            +L + LLN+L G   +                     V +I AT + + LD  L+RPGR
Sbjct: 281 TMLELELLNQLGGFDSR-------------------EDVKVIMATKQVETLDPVLIRPGR 321

Query: 644 LDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLA 703
           +DK I    PD K +  I ++ T  M +  DV+L++L      FSGAD++ +CTEA L+A
Sbjct: 322 IDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMA 381

Query: 704 LQENGLDATTVKQEHFLKSLKTV 726
           L+E+ + AT    E F KS+++V
Sbjct: 382 LREHRMKAT---NEDFKKSIESV 401



 Score =  112 bits (281), Expect = 1e-24
 Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 24/235 (10%)

Query: 193 EAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVR 252
           +A  +  V  GGL      ++E + LPL +P     +G   P+GV+L GPPG        
Sbjct: 165 KAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA------ 218

Query: 253 AVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR 312
              R  G+EL+            G+  + VR+VFQ A E A   PS++F DE++A+  +R
Sbjct: 219 TFLRVVGSELIQKYL--------GDGPKLVRQVFQVAEEHA---PSIMFTDEIEAIGTKR 267

Query: 313 ------GSRAPESRVVA-QVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVV 365
                 G R  +  ++  ++L  L G     +V V+ AT + + LDP L RPGR D+++ 
Sbjct: 268 YDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIE 327

Query: 366 IGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420
              P  K +K I Q+ TS+M +++ V L  L      + GAD+ A+C EA + AL
Sbjct: 328 FHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMAL 382


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,748,837
Number of Sequences: 37866
Number of extensions: 1536379
Number of successful extensions: 6029
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 5513
Number of HSP's gapped (non-prelim): 361
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.