Guide to the Human Genome
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Search of human proteins with 115298668

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo
sapiens]
         (357 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   735   0.0  
gi|23199987 WD repeat domain 5B [Homo sapiens]                        173   2e-43
gi|16554629 WD repeat domain 5 [Homo sapiens]                         172   5e-43
gi|16554627 WD repeat domain 5 [Homo sapiens]                         172   5e-43
gi|32189425 WD repeat domain 69 [Homo sapiens]                        142   4e-34
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]         135   4e-32
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]         135   4e-32
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    128   9e-30
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            128   9e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            128   9e-30
gi|26665869 WD repeat domain 51B [Homo sapiens]                       125   6e-29
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            124   1e-28
gi|113865883 WD repeat domain 38 [Homo sapiens]                       123   2e-28
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]          122   6e-28
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   119   4e-27
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   119   5e-27
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...   115   5e-26
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...   115   5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   115   6e-26
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   115   6e-26
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   115   6e-26
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    112   7e-25
gi|7706657 cell division cycle 40 homolog [Homo sapiens]              108   6e-24
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ...   108   1e-23
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s...   108   1e-23
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           107   2e-23
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    106   3e-23
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   105   8e-23
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   104   1e-22
gi|16445438 bromodomain and WD repeat domain containing 1 isofor...   103   2e-22

>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  735 bits (1897), Expect = 0.0
 Identities = 357/357 (100%), Positives = 357/357 (100%)

Query: 1   MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM 60
           MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
Sbjct: 1   MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM 60

Query: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
           LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
Sbjct: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180

Query: 181 IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
           IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
Sbjct: 181 IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240

Query: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
           LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300

Query: 301 AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
           AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sbjct: 301 AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  173 bits (438), Expect = 2e-43
 Identities = 102/288 (35%), Positives = 160/288 (55%), Gaps = 11/288 (3%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
           L GH   V   KF PNG  LAS+  DRLI++W  Y D     TL GH+  + ++ +++D 
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNLEISDVAWSSDS 95

Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
           S L SAS DKT+ +WD  +G+ +K LKGH+++V  C        L+ +GS D TVK+W++
Sbjct: 96  SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN-FNPPSNLIISGSFDETVKIWEV 154

Query: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS-VT 239
           +    ++T   ++  V AV FN +   I+SG  D   ++WD    +   T+    +  V+
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
            +  S  G Y+L+  +DNT+++WD      + RC+K + G  H  EK  +  ++S  G K
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYS----RGRCLKTYTG--HKNEKYCIFANFSVTGGK 268

Query: 300 -IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346
            I +GS D  VY+W+  ++ I+ KL GH   +   A HP E +I SA+
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316



 Score =  107 bits (267), Expect = 2e-23
 Identities = 60/208 (28%), Positives = 105/208 (50%), Gaps = 9/208 (4%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
           L GH   V+CC F+P  + + S  FD  + +W V  G C    TL  HS  V  +H+N  
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCS 178

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           GS++ S S D    +WD+ +G+ +K L    +   S        + + T + D T+KLWD
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238

Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
             +   ++T+   +N    +   F+ T  + I+SG  DN + +W+L+  ++   ++GH D
Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 298

Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
            V   +     + + S A++N  T+++W
Sbjct: 299 VVISAACHPTENLIASAALENDKTIKLW 326


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  172 bits (435), Expect = 5e-43
 Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)

Query: 34  AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92
           A + Q TP +   Q+ P       A    L+GH   V   KF PNG  LAS+  D+LI +
Sbjct: 12  AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71

Query: 93  WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152
           W  Y D     T+ GH   + ++ +++D ++L SAS DKT+ +WD  +G+ +K LKGH++
Sbjct: 72  WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130

Query: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209
           +V  C      PQ  L+ +GS D +V++WD++    ++T   ++  V AV FN     I+
Sbjct: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187

Query: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
           S   D   ++WD    +   T+    +  V+ +  S  G Y+L+  +DNT+++WD     
Sbjct: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244

Query: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327
            K +C+K + G  H  EK  +  ++S  G K I +GS D  VY+W+  ++ I+ KL GH 
Sbjct: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301

Query: 328 GSINEVAFHPDEPIIISAS 346
             +   A HP E II SA+
Sbjct: 302 DVVISTACHPTENIIASAA 320



 Score =  109 bits (273), Expect = 3e-24
 Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
           L GH   V+CC F+P  + + S  FD  + +W+V  G C    TL  HS  V  +H+N D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           GS++ S+S D    +WD+ +G+ +K L    +   S        + +   + D T+KLWD
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242

Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
             K   ++T+   +N    +   F+ T  + I+SG  DN + +W+L+  ++   ++GH D
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302

Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
            V   +     + + S A++N  T+++W
Sbjct: 303 VVISTACHPTENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  172 bits (435), Expect = 5e-43
 Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)

Query: 34  AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92
           A + Q TP +   Q+ P       A    L+GH   V   KF PNG  LAS+  D+LI +
Sbjct: 12  AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71

Query: 93  WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152
           W  Y D     T+ GH   + ++ +++D ++L SAS DKT+ +WD  +G+ +K LKGH++
Sbjct: 72  WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130

Query: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209
           +V  C      PQ  L+ +GS D +V++WD++    ++T   ++  V AV FN     I+
Sbjct: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187

Query: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
           S   D   ++WD    +   T+    +  V+ +  S  G Y+L+  +DNT+++WD     
Sbjct: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244

Query: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327
            K +C+K + G  H  EK  +  ++S  G K I +GS D  VY+W+  ++ I+ KL GH 
Sbjct: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301

Query: 328 GSINEVAFHPDEPIIISAS 346
             +   A HP E II SA+
Sbjct: 302 DVVISTACHPTENIIASAA 320



 Score =  109 bits (273), Expect = 3e-24
 Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
           L GH   V+CC F+P  + + S  FD  + +W+V  G C    TL  HS  V  +H+N D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           GS++ S+S D    +WD+ +G+ +K L    +   S        + +   + D T+KLWD
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242

Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
             K   ++T+   +N    +   F+ T  + I+SG  DN + +W+L+  ++   ++GH D
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302

Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
            V   +     + + S A++N  T+++W
Sbjct: 303 VVISTACHPTENIIASAALENDKTIKLW 330


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  142 bits (359), Expect = 4e-34
 Identities = 83/283 (29%), Positives = 145/283 (51%), Gaps = 12/283 (4%)

Query: 77  NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAV 135
           +GS   +  +DR   LW+     +   TL+GH   V  + +N   G  + + S DKT  +
Sbjct: 103 SGSCFITGSYDRTCKLWDTASG-EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161

Query: 136 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTY 194
           W  ETG+     +GHT+ +  C        LV TGS D T KLWDI+    + T + ++ 
Sbjct: 162 WSVETGKCYHTFRGHTAEI-VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA 220

Query: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254
           ++++++FN + D+II+G  D+ + VWD    +    + GH   ++  S + + S +L+ +
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280

Query: 255 MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT 314
           MD T ++WD    A   +CV    G+    +  +L   +   G  IA  SAD    ++  
Sbjct: 281 MDKTCKLWD----ATNGKCVATLTGH----DDEILDSCFDYTGKLIATASADGTARIFSA 332

Query: 315 TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
            +R+ + KL GH G I++++F+P    +++ SSDK   + + Q
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375



 Score =  139 bits (350), Expect = 4e-33
 Identities = 83/290 (28%), Positives = 142/290 (48%), Gaps = 14/290 (4%)

Query: 62  LSGHEGEVYCCKFH-PNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNT 119
           L GH   VY   F+ P G  +A+  FD+   LW+V  G C  Y T +GH+  ++ L +N 
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNP 187

Query: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
             +++ + S D T  +WD + GE V  L+GH++ + S      G +++ TGS D TV +W
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVW 246

Query: 180 DIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
           D      +     +  ++ + +FN     I++G +D   K+WD    K   T+ GH D +
Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306

Query: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
                   G  + + + D T R++     A   +C+   +G+    E  + + S++P G+
Sbjct: 307 LDSCFDYTGKLIATASADGTARIFS----AATRKCIAKLEGH----EGEISKISFNPQGN 358

Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
            +  GS+D+   +WD  + + L  L GH   I   AF+    I+I+ S D
Sbjct: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408



 Score =  127 bits (320), Expect = 1e-29
 Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 9/248 (3%)

Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
           +  LK H   +  +  N  GS   + S D+T  +WD+ +GE +  L+GH + V +     
Sbjct: 85  FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144

Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
                + TGS D T KLW +       TF+ +T +++ ++FN  S  + +G +D   K+W
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204

Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
           D++  +  YT+RGH+  +  LS ++ G  +++ + D+TV VWD    A   R V I  G 
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----ADTGRKVNILIG- 259

Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
            H  E +    +W  D S I  GS D+   +WD T+ + +  L GH   I +  F     
Sbjct: 260 -HCAEISSASFNW--DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316

Query: 341 IIISASSD 348
           +I +AS+D
Sbjct: 317 LIATASAD 324



 Score =  113 bits (283), Expect = 2e-25
 Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 45/242 (18%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           GH  E+ C  F+P  + +A+   D    LW++    + Y TL+GHS  ++ L +NT G  
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY-TLRGHSAEIISLSFNTSGDR 233

Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
           + + S D TV VWD++TG +V  L GH + ++S         L+ TGS D T KLWD   
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSA-SFNWDCSLILTGSMDKTCKLWDATN 292

Query: 184 KAAIQT------------FQNTYQVLA-------------------------------VT 200
              + T            F  T +++A                               ++
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352

Query: 201 FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260
           FN   + +++G  D   ++WD +  +    + GH D +   + + +G+ +++ + DNT R
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412

Query: 261 VW 262
           +W
Sbjct: 413 IW 414



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 39/121 (32%), Positives = 68/121 (56%), Gaps = 2/121 (1%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
           +  L+GH+ E+    F   G  +A+A  D    +++        A L+GH G + ++ +N
Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA-ATRKCIAKLEGHEGEISKISFN 354

Query: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
             G+ L + S+DKT  +WD++TG+ ++ L+GHT  + SC    +G  +V TGS D T ++
Sbjct: 355 PQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKG-NIVITGSKDNTCRI 413

Query: 179 W 179
           W
Sbjct: 414 W 414


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score =  135 bits (341), Expect = 4e-32
 Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 30/318 (9%)

Query: 32  PGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLIL 91
           PG+G++   P   L               +   H+GEV   +F P    LA+ G DR + 
Sbjct: 302 PGSGKEVRVPATAL--------------CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVK 347

Query: 92  LWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH 150
           LW V+G+ C+   +L G +  +  + +++ GS L +AS D    +W  +       L GH
Sbjct: 348 LWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH 407

Query: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND---TSDQ 207
           +  V S        ++V +GS D T+KLWD+R K  I+T          + ND   T   
Sbjct: 408 SGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVCIKTV-----FAGSSCNDIVCTEQC 461

Query: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
           ++SG  D  I+ WD+R   +   M      +T L L+ E + LLS + D+ ++V D+R  
Sbjct: 462 VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCSRDDLLKVIDLRTN 520

Query: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGH 326
           A K+     F         +  R  +SPDGS +AAGSA+  +Y+W   + ++   L   H
Sbjct: 521 AIKQ----TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQH 576

Query: 327 AGSINEVAFHPDEPIIIS 344
           + SIN VA+ P    ++S
Sbjct: 577 SSSINAVAWSPSGSHVVS 594



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 21/195 (10%)

Query: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDI 217
           G +L+ TG  D  VKLW++  +     F+ +       + ++ F+     +++   D   
Sbjct: 333 GSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFAS 390

Query: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK-I 276
           ++W +   +L +T+ GH+  V       + + ++S + D T+++WD+R     + C+K +
Sbjct: 391 RIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR----SKVCIKTV 446

Query: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
           F G+  N      +C        + +G  D+ +  WD  S  I+ ++    G I  +  +
Sbjct: 447 FAGSSCNDIVCTEQC--------VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLN 497

Query: 337 PDEPIIISASSDKRL 351
           P+   ++S S D  L
Sbjct: 498 PERTELLSCSRDDLL 512



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 6/124 (4%)

Query: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
           H   V  +  S     L +  MD  V++W+V      E+C   F+G++      +    +
Sbjct: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFG----EKCE--FKGSLSGSNAGITSIEF 374

Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
              GS + A S D    +W     R+ + L GH+G +    F  D   I+S S D+ L +
Sbjct: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434

Query: 354 GEIQ 357
            +++
Sbjct: 435 WDLR 438



 Score = 28.5 bits (62), Expect = 9.7
 Identities = 14/63 (22%), Positives = 28/63 (44%)

Query: 74  FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
           F P+GS +A+   +  + +W+V          K HS ++  + ++  GS + S       
Sbjct: 542 FSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKA 601

Query: 134 AVW 136
            +W
Sbjct: 602 VLW 604


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score =  135 bits (341), Expect = 4e-32
 Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 30/318 (9%)

Query: 32  PGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLIL 91
           PG+G++   P   L               +   H+GEV   +F P    LA+ G DR + 
Sbjct: 283 PGSGKEVRVPATAL--------------CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVK 328

Query: 92  LWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH 150
           LW V+G+ C+   +L G +  +  + +++ GS L +AS D    +W  +       L GH
Sbjct: 329 LWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH 388

Query: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND---TSDQ 207
           +  V S        ++V +GS D T+KLWD+R K  I+T          + ND   T   
Sbjct: 389 SGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVCIKTV-----FAGSSCNDIVCTEQC 442

Query: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
           ++SG  D  I+ WD+R   +   M      +T L L+ E + LLS + D+ ++V D+R  
Sbjct: 443 VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCSRDDLLKVIDLRTN 501

Query: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGH 326
           A K+     F         +  R  +SPDGS +AAGSA+  +Y+W   + ++   L   H
Sbjct: 502 AIKQ----TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQH 557

Query: 327 AGSINEVAFHPDEPIIIS 344
           + SIN VA+ P    ++S
Sbjct: 558 SSSINAVAWSPSGSHVVS 575



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 21/195 (10%)

Query: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDI 217
           G +L+ TG  D  VKLW++  +     F+ +       + ++ F+     +++   D   
Sbjct: 314 GSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFAS 371

Query: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK-I 276
           ++W +   +L +T+ GH+  V       + + ++S + D T+++WD+R     + C+K +
Sbjct: 372 RIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR----SKVCIKTV 427

Query: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
           F G+  N      +C        + +G  D+ +  WD  S  I+ ++    G I  +  +
Sbjct: 428 FAGSSCNDIVCTEQC--------VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLN 478

Query: 337 PDEPIIISASSDKRL 351
           P+   ++S S D  L
Sbjct: 479 PERTELLSCSRDDLL 493



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 6/124 (4%)

Query: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
           H   V  +  S     L +  MD  V++W+V      E+C   F+G++      +    +
Sbjct: 302 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFG----EKCE--FKGSLSGSNAGITSIEF 355

Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
              GS + A S D    +W     R+ + L GH+G +    F  D   I+S S D+ L +
Sbjct: 356 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 415

Query: 354 GEIQ 357
            +++
Sbjct: 416 WDLR 419



 Score = 28.5 bits (62), Expect = 9.7
 Identities = 14/63 (22%), Positives = 28/63 (44%)

Query: 74  FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
           F P+GS +A+   +  + +W+V          K HS ++  + ++  GS + S       
Sbjct: 523 FSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKA 582

Query: 134 AVW 136
            +W
Sbjct: 583 VLW 585


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  128 bits (321), Expect = 9e-30
 Identities = 67/222 (30%), Positives = 120/222 (54%), Gaps = 11/222 (4%)

Query: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQV 196
           ++T  +++ +  H S V+S    +   +L+ TG DD  V LW I K   I +   +T  V
Sbjct: 7   TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66

Query: 197 LAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
            +V  N   + I++G     I+VWDL   K+  T+ GH  ++  L     G ++ S + D
Sbjct: 67  ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126

Query: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDTT 315
             +++WD+R    ++ CV  ++G+        +RC  +SPDG  +A+ + D  V +WD T
Sbjct: 127 TNIKLWDIR----RKGCVFRYRGH-----SQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177

Query: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
           + +++ + PGH G +N V FHP+E ++ S SSD+ +   +++
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219



 Score =  105 bits (261), Expect = 8e-23
 Identities = 65/234 (27%), Positives = 116/234 (49%), Gaps = 11/234 (4%)

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           G +L +   D  V +W       +  L GHTS V S        +L+  GS  G++++WD
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR-LNTPEELIVAGSQSGSIRVWD 91

Query: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
           +     ++T   +   + ++ F+   + + SG  D +IK+WD+R+    +  RGH+ +V 
Sbjct: 92  LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
            L  S +G +L S A D+TV++WD+       + +  F G  H    N++   + P+   
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTA----GKMMSEFPG--HTGPVNVVE--FHPNEYL 203

Query: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK-RLY 352
           +A+GS+DR +  WD    +++  + G  G +  V F+PD   + S   D  R+Y
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVY 257



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 66/239 (27%), Positives = 111/239 (46%), Gaps = 12/239 (5%)

Query: 77  NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 136
           +G  LA+ G D  + LW++    +   +L GH+  V  +  NT   ++ + S   ++ VW
Sbjct: 32  SGRLLATGGDDCRVNLWSI-NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90

Query: 137 DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ- 195
           D E  + ++ L GH + + S      G + V +GS D  +KLWDIR+K  +  ++   Q 
Sbjct: 91  DLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQA 149

Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
           V  + F+     + S   D+ +K+WDL   K+     GH   V  +        L S + 
Sbjct: 150 VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSS 209

Query: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF-VYVWD 313
           D T+R WD+  F     C++   G V +         ++PDG  + +G  D   VY W+
Sbjct: 210 DRTIRFWDLEKFQVVS-CIEGEPGPVRS-------VLFNPDGCCLYSGCQDSLRVYGWE 260



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 58/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)

Query: 46  QAGPPRCSSLQAPIML--LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY--GDCDN 101
           Q+G  R   L+A  +L  L GH+  +    FHP G  +AS   D  I LW++   G    
Sbjct: 83  QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142

Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
           Y   +GHS AV  L ++ DG  L SA+ D TV +WD   G+ +    GHT  VN      
Sbjct: 143 Y---RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN-VVEFH 198

Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDN 215
               L+ +GS D T++ WD+ K   +   +     V +V FN     + SG  D+
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  128 bits (321), Expect = 9e-30
 Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           GH   V C  F  N   LAS   D  +++W++      Y    GH  AV  ++++  G +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75

Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182
           L S S DKTV +W           + HT+ V S +    G   V T SDD TVK+W   R
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134

Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
           +K      Q+   V    F+     I+S   D  +K+WD    +  ++   H   VT + 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
               G+ + +  MDNTV+VWDVR      R ++ +Q  +H+   N L  S+ P G+ +  
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246

Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            S+D  + + D    R+LY L GH G    VAF        S  SD+++
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295



 Score =  124 bits (312), Expect = 1e-28
 Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)

Query: 63  SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
           +GH+  V C  F P+G  LAS   D+ + +W  NV G+       + H+  V  +H+ +D
Sbjct: 58  TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           G    +AS DKTV VW +   + +  L  H ++V  C       +L+ + SDD TVKLWD
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173

Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
              +  + ++ ++   V  V F+ +   I + G+DN +KVWD+R ++L    + H+ +V 
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
           GLS    G+YL++ + D+T+++ D+     + R +      +H  +      ++S  G  
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 285

Query: 300 IAAGSADRFVYVW 312
            A+G +D  V VW
Sbjct: 286 FASGGSDEQVMVW 298



 Score =  108 bits (269), Expect = 1e-23
 Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)

Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
           KGH  AV  + ++ +   L S S D  + VW  +   R  R  GH   V +C        
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74

Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
           L+ +GS D TV++W    K     F+ +T  V +V F       ++   D  +KVW   +
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
            K  +++  H + V     S +G  ++S + D TV++WD           K  +  VH++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183

Query: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
            ++   +    + P G+ IAA   D  V VWD  + R+L     H+ ++N ++FHP    
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 342 IISASSDKRL 351
           +I+ASSD  L
Sbjct: 244 LITASSDSTL 253



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 34/196 (17%)

Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
           V  V F+  + Q+ SG +D+ + VW ++     Y   GH D+VT ++ S  G  L S + 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 256 DNTVRVW-------------------------DVRPF--APKERCVKIFQGNVHNF---- 284
           D TVR+W                         D + F  A  ++ VK++  +   F    
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 285 --EKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
               N +RC+ +SPDG  I + S D+ V +WD +SR  ++    H G +  V FHP    
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 342 IISASSDKRLYMGEIQ 357
           I +A  D  + + +++
Sbjct: 202 IAAAGMDNTVKVWDVR 217



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
           LS H   V C KF P+G  + SA  D+ + LW+      V+  C+       H G V  +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 193

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
            ++  G+ + +A  D TV VWD  T   ++  + H++ VN       G  L+ T S D T
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 252

Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
           +K+ D+ +   + T   +      V F+ T +   SGG D  + VW
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
           H   V    FHP+G+ L +A  D  + + ++      Y TL GH G    + ++  G   
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286

Query: 125 FSASTDKTVAVWDS 138
            S  +D+ V VW S
Sbjct: 287 ASGGSDEQVMVWKS 300


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  128 bits (321), Expect = 9e-30
 Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           GH   V C  F  N   LAS   D  +++W++      Y    GH  AV  ++++  G +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75

Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182
           L S S DKTV +W           + HT+ V S +    G   V T SDD TVK+W   R
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134

Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
           +K      Q+   V    F+     I+S   D  +K+WD    +  ++   H   VT + 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
               G+ + +  MDNTV+VWDVR      R ++ +Q  +H+   N L  S+ P G+ +  
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246

Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            S+D  + + D    R+LY L GH G    VAF        S  SD+++
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295



 Score =  124 bits (312), Expect = 1e-28
 Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)

Query: 63  SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
           +GH+  V C  F P+G  LAS   D+ + +W  NV G+       + H+  V  +H+ +D
Sbjct: 58  TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           G    +AS DKTV VW +   + +  L  H ++V  C       +L+ + SDD TVKLWD
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173

Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
              +  + ++ ++   V  V F+ +   I + G+DN +KVWD+R ++L    + H+ +V 
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
           GLS    G+YL++ + D+T+++ D+     + R +      +H  +      ++S  G  
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 285

Query: 300 IAAGSADRFVYVW 312
            A+G +D  V VW
Sbjct: 286 FASGGSDEQVMVW 298



 Score =  108 bits (269), Expect = 1e-23
 Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)

Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
           KGH  AV  + ++ +   L S S D  + VW  +   R  R  GH   V +C        
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74

Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
           L+ +GS D TV++W    K     F+ +T  V +V F       ++   D  +KVW   +
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
            K  +++  H + V     S +G  ++S + D TV++WD           K  +  VH++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183

Query: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
            ++   +    + P G+ IAA   D  V VWD  + R+L     H+ ++N ++FHP    
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 342 IISASSDKRL 351
           +I+ASSD  L
Sbjct: 244 LITASSDSTL 253



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 34/196 (17%)

Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
           V  V F+  + Q+ SG +D+ + VW ++     Y   GH D+VT ++ S  G  L S + 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 256 DNTVRVW-------------------------DVRPF--APKERCVKIFQGNVHNF---- 284
           D TVR+W                         D + F  A  ++ VK++  +   F    
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 285 --EKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
               N +RC+ +SPDG  I + S D+ V +WD +SR  ++    H G +  V FHP    
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 342 IISASSDKRLYMGEIQ 357
           I +A  D  + + +++
Sbjct: 202 IAAAGMDNTVKVWDVR 217



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
           LS H   V C KF P+G  + SA  D+ + LW+      V+  C+       H G V  +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 193

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
            ++  G+ + +A  D TV VWD  T   ++  + H++ VN       G  L+ T S D T
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 252

Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
           +K+ D+ +   + T   +      V F+ T +   SGG D  + VW
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
           H   V    FHP+G+ L +A  D  + + ++      Y TL GH G    + ++  G   
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286

Query: 125 FSASTDKTVAVWDS 138
            S  +D+ V VW S
Sbjct: 287 ASGGSDEQVMVWKS 300


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  125 bits (314), Expect = 6e-29
 Identities = 80/304 (26%), Positives = 144/304 (47%), Gaps = 13/304 (4%)

Query: 53  SSLQAPIM--LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110
           S+ + P++     GH+  +      PNG  LA+A +D  ++LWN       Y  + GH  
Sbjct: 3   SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKD 61

Query: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
            V  + ++  G++L SAS D+TV +W  +   +    K HT+ V S   +  G Q + T 
Sbjct: 62  VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG-QFLATA 120

Query: 171 SDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
           S+D ++K+W + R++     +++T+ V    F+     I+S   D  IK+WD    +   
Sbjct: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180

Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
                      +  +  G+ + S   D TV+VWDVR      + ++ +Q  VH+   N +
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQ--VHSGGVNCI 234

Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
             S+ P G+ +   S+D  + + D    R++Y L GH G +  V+F     +  S  +D 
Sbjct: 235 --SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292

Query: 350 RLYM 353
           ++ +
Sbjct: 293 QVLL 296



 Score =  124 bits (312), Expect = 1e-28
 Identities = 86/308 (27%), Positives = 143/308 (46%), Gaps = 24/308 (7%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           GH+  V   +F P+G+ LASA  DR + LW +      ++  K H+  V  + ++ DG  
Sbjct: 58  GHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQF 116

Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
           L +AS DK++ VW       +  L  HT +V  C       +L+ + S+D T+K+WD   
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVR-CAKFSPDGRLIVSCSEDKTIKIWDTTN 175

Query: 184 KAAIQTFQNTYQVLA-VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
           K  +  F ++      V FN +   I S G D  +KVWD+R NKL    + H+  V  +S
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235

Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
               G+YL++ + D T+++ D+     + R +   QG+       +   S+S  G   A+
Sbjct: 236 FHPSGNYLITASSDGTLKILDLL----EGRLIYTLQGHTGP----VFTVSFSKGGELFAS 287

Query: 303 GSADRFVYVWDT-------------TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
           G AD  V +W T               +R+ +  P H   I     HP E  + +   + 
Sbjct: 288 GGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINP 347

Query: 350 RLYMGEIQ 357
           +L + ++Q
Sbjct: 348 KLEVIDLQ 355



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 52/212 (24%), Positives = 101/212 (47%), Gaps = 12/212 (5%)

Query: 148 KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVL-AVTFNDTSD 206
           KGH + + S   +  G QL  T S D  + LW+ +  A    +     V+ +V F+   +
Sbjct: 15  KGHKAAITSLDLSPNGKQLA-TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73

Query: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
            + S   D  +++W   +       + H   V  +  S++G +L + + D +++VW +  
Sbjct: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY- 132

Query: 267 FAPKERCVKIFQGNVHNFEKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
              ++R +     + H      +RC+ +SPDG  I + S D+ + +WDTT+++ +     
Sbjct: 133 ---RQRFLYSLYRHTH-----WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD 184

Query: 326 HAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
             G  N V F+P    I SA SD+ + + +++
Sbjct: 185 SVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 16/40 (40%), Positives = 18/40 (45%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD 98
           I  L GH G V+   F   G   AS G D  +LLW    D
Sbjct: 263 IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  124 bits (312), Expect = 1e-28
 Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)

Query: 63  SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
           +GH+  V C  F P+G  LAS   D+ + +W  NV G+       + H+  V  +H+ +D
Sbjct: 20  TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 76

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
           G    +AS DKTV VW +   + +  L  H ++V  C       +L+ + SDD TVKLWD
Sbjct: 77  GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 135

Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
              +  + ++ ++   V  V F+ +   I + G+DN +KVWD+R ++L    + H+ +V 
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
           GLS    G+YL++ + D+T+++ D+     + R +      +H  +      ++S  G  
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 247

Query: 300 IAAGSADRFVYVW 312
            A+G +D  V VW
Sbjct: 248 FASGGSDEQVMVW 260



 Score =  113 bits (283), Expect = 2e-25
 Identities = 79/266 (29%), Positives = 123/266 (46%), Gaps = 11/266 (4%)

Query: 87  DRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKR 146
           D  +++W++      Y    GH  AV  ++++  G +L S S DKTV +W          
Sbjct: 2   DSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 147 LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTS 205
            + HT+ V S +    G   V T SDD TVK+W   R+K      Q+   V    F+   
Sbjct: 61  FRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119

Query: 206 DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
             I+S   D  +K+WD    +  ++   H   VT +     G+ + +  MDNTV+VWDVR
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179

Query: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
                 R ++ +Q  +H+   N L  S+ P G+ +   S+D  + + D    R+LY L G
Sbjct: 180 T----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231

Query: 326 HAGSINEVAFHPDEPIIISASSDKRL 351
           H G    VAF        S  SD+++
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQV 257



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
           LS H   V C KF P+G  + SA  D+ + LW+      V+  C+       H G V  +
Sbjct: 103 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 155

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
            ++  G+ + +A  D TV VWD  T   ++  + H++ VN       G  L+ T S D T
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 214

Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
           +K+ D+ +   + T   +      V F+ T +   SGG D  + VW
Sbjct: 215 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 48/179 (26%), Positives = 80/179 (44%), Gaps = 34/179 (18%)

Query: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW---------- 262
           +D+ + VW ++     Y   GH D+VT ++ S  G  L S + D TVR+W          
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 263 ---------------DVRPF--APKERCVKIFQGNVHNF------EKNLLRCS-WSPDGS 298
                          D + F  A  ++ VK++  +   F        N +RC+ +SPDG 
Sbjct: 61  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
            I + S D+ V +WD +SR  ++    H G +  V FHP    I +A  D  + + +++
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
           H   V    FHP+G+ L +A  D  + + ++      Y TL GH G    + ++  G   
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 248

Query: 125 FSASTDKTVAVWDS 138
            S  +D+ V VW S
Sbjct: 249 ASGGSDEQVMVWKS 262


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  123 bits (309), Expect = 2e-28
 Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 8/239 (3%)

Query: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167
           H G V    ++ DG ML + S D  V  W++ +G+ + RL GHT  V  C  +  G  L 
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDG-HLF 78

Query: 168 CTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
            + S D TV+LWD+ +   ++  +   + V  V+F+  S Q+ SGG D  + +WD++  +
Sbjct: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138

Query: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
           +   + GH DS+     S   + L + + D+TV +WD+R   P      +    +     
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP-----AVSHQALEGHSA 193

Query: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
           N+    +S  G  +A+GS D+ +++W  T+  +L +L GH   +  +AF PDE  + SA
Sbjct: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA 251



 Score =  110 bits (274), Expect = 3e-24
 Identities = 72/251 (28%), Positives = 117/251 (46%), Gaps = 17/251 (6%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
           L GH G V  C+F P+G   ASA  D  + LW+V         LKGH  +V  + ++ D 
Sbjct: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV-ARAKCLRVLKGHQRSVETVSFSPDS 117

Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC--TGSDDGTVKLW 179
             L S   DK V +WD ++G+ ++ L GH   + S   +   P + C  TGS D TV +W
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSWDSTVHIW 174

Query: 180 DIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
           D+R      + Q  +     ++      S  + SG  D  I +W    + L   ++GH  
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234

Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
            V  ++ S +  +L S      V+VWD        +C++  +G +         C+++PD
Sbjct: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCN----TGKCLETLKGVLDVAH----TCAFTPD 286

Query: 297 GSKIAAGSADR 307
           G  + +G+AD+
Sbjct: 287 GKILVSGAADQ 297



 Score =  101 bits (251), Expect = 1e-21
 Identities = 80/290 (27%), Positives = 136/290 (46%), Gaps = 17/290 (5%)

Query: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
           H GEV    F P+G  L +   D  +  W           L GH+G V    ++ DG + 
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-QLLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 125 FSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK 184
            SAS D TV +WD    + ++ LKGH   V +   +    QL  +G  D  V LWD++  
Sbjct: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL-ASGGWDKRVMLWDVQSG 137

Query: 185 AAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT---MRGHADSVTG 240
             ++    +   + +  F+ T + + +G  D+ + +WDLR      +   + GH+ +++ 
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197

Query: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI-FQGNVHNFEKNLLRCSWSPDGSK 299
           L  S+ G  L S + D T+ +W      P    + I  +G+V  + K++   ++SPD   
Sbjct: 198 LCYSASG-LLASGSWDKTIHIW-----KPTTSSLLIQLKGHV-TWVKSI---AFSPDELW 247

Query: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
           +A+    R V VWD  + + L  L G     +  AF PD  I++S ++D+
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 45/167 (26%), Positives = 84/167 (50%), Gaps = 8/167 (4%)

Query: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYL 250
           Q+  +V +  F+     +++G  D  +  W+ R  +L + + GH   V     S +G   
Sbjct: 19  QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310
            S + D TVR+WDV     + +C+++ +G+  + E      S+SPD  ++A+G  D+ V 
Sbjct: 79  ASASCDCTVRLWDVA----RAKCLRVLKGHQRSVET----VSFSPDSRQLASGGWDKRVM 130

Query: 311 VWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
           +WD  S ++L  L GH  SI    F P    + + S D  +++ +++
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 31/77 (40%), Positives = 41/77 (53%), Gaps = 4/77 (5%)

Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
           R VK F    H  E N    ++SPDG  +  GS D  VY W+T S ++L++L GH G + 
Sbjct: 12  RRVKFF--GQHGGEVN--SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK 67

Query: 332 EVAFHPDEPIIISASSD 348
              F PD  +  SAS D
Sbjct: 68  FCRFSPDGHLFASASCD 84


>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
          Length = 619

 Score =  122 bits (305), Expect = 6e-28
 Identities = 92/309 (29%), Positives = 146/309 (47%), Gaps = 13/309 (4%)

Query: 50  PRCSSLQAPIM---LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-CDNYATL 105
           P C + + P     +L  H  EV   +F PN S LA+ G DRLI LWNV G   +   TL
Sbjct: 317 PVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTL 376

Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
           +G  G++  + ++  G  + +A+ ++   +W     +  + L GH   V +        Q
Sbjct: 377 EGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQ 436

Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
            V TGS D TVK WD+ +    +T         V   D    IISG  D  I+ WD R  
Sbjct: 437 AV-TGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGD--HIIISGHNDQKIRFWDSRGP 493

Query: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
             T  +      VT LSLS +  +LLS + DNT++V D+R         ++F+ +     
Sbjct: 494 HCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLR----VSNIRQVFRADGFKCG 548

Query: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG-HAGSINEVAFHPDEPIIIS 344
            +  +  +SPD S   AGS D  +Y+WD  + ++  +L G H  ++N VA+      ++S
Sbjct: 549 SDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVS 608

Query: 345 ASSDKRLYM 353
               +++ +
Sbjct: 609 VDQGRKVVL 617


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  119 bits (298), Expect = 4e-27
 Identities = 86/315 (27%), Positives = 145/315 (46%), Gaps = 31/315 (9%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
           LSGH   V    FHP  S + SA  D  I +W+ Y   D   TLKGH+ +V ++ ++  G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-YETGDFERTLKGHTDSVQDISFDHSG 162

Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
            +L S S D T+ +WD +  E ++ + GH   V+S      G  +V + S D T+K+W++
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDKTIKMWEV 221

Query: 182 RKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
           +    ++TF    + V  V  N     I S   D  ++VW +   +    +R H   V  
Sbjct: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281

Query: 241 LSLSSEGSY--------------------LLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
           +S + E SY                    LLS + D T+++WDV        C+    G+
Sbjct: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV----STGMCLMTLVGH 337

Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
             N+ + +L   +   G  I + + D+ + VWD  ++R +  L  H   +  + FH   P
Sbjct: 338 -DNWVRGVL---FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAP 393

Query: 341 IIISASSDKRLYMGE 355
            +++ S D+ + + E
Sbjct: 394 YVVTGSVDQTVKVWE 408



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 68/229 (29%), Positives = 102/229 (44%), Gaps = 25/229 (10%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHY 117
           I  + GH+  V      PNG  + SA  D+ I +W V  G C    T  GH   V  +  
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMVRP 242

Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN-------SCYPA---------- 160
           N DG+++ S S D+TV VW   T E    L+ H   V        S Y +          
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302

Query: 161 ---RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
              + GP L+ +GS D T+K+WD+     + T   +   V  V F+     I+S   D  
Sbjct: 303 KSGKPGPFLL-SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361

Query: 217 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
           ++VWD +  +   T+  H   VT L       Y+++ ++D TV+VW+ R
Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 12/179 (6%)

Query: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI---DNDIKVWDLRQNKLTYTMRGHADSV 238
           +K  ++   Q     L    N+  ++  SGG      D K W  R  +  Y + GH   V
Sbjct: 53  KKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPE-KYALSGHRSPV 111

Query: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
           T +      S ++S + D T++VWD       ER +K    +V +        S+   G 
Sbjct: 112 TRVIFHPVFSVMVSASEDATIKVWDYET-GDFERTLKGHTDSVQDI-------SFDHSGK 163

Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
            +A+ SAD  + +WD      +  + GH  +++ VA  P+   I+SAS DK + M E+Q
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score =  119 bits (297), Expect = 5e-27
 Identities = 78/305 (25%), Positives = 144/305 (47%), Gaps = 10/305 (3%)

Query: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
           P  +LSGHE  V  C F  + + L S  +D  + LW+                 V+E   
Sbjct: 94  PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153

Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
             D S + +AS DKTV  WD ETG+ + +++ + +F+ SC  +  G  +V     D  + 
Sbjct: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGIC 212

Query: 178 LWDIRKKAAIQTFQN--TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-RGH 234
           + D      +   ++  T  + +  F+  S ++ S  +D  IK+WD+       T+ + H
Sbjct: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272

Query: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP--FAPKERCVKIFQGNVHNFEKNLLRCS 292
           +++++    +  G +L +++ D  +++W+V    F     CV + QG+    E ++  C 
Sbjct: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH----EGSVSSCH 328

Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352
           ++ D S + +G  DR V +WD         L GH   + +VA   ++  I+SAS D+ + 
Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388

Query: 353 MGEIQ 357
           +  I+
Sbjct: 389 LWNIE 393



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 12/169 (7%)

Query: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
           H   +  C F P+   +AS   DR I +W+V          K HS A+    +   G  L
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288

Query: 125 FSASTDKTVAVWDSETGE------RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
            ++S DK + +W+  TGE       V  ++GH   V+SC+ AR    L+ +G  D TV +
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLI-SGGFDRTVAI 347

Query: 179 WDIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
           WD+    +K +++   +   V+ V  ++    I+S   D  +++W++ +
Sbjct: 348 WDVAEGYRKLSLKGHND--WVMDVAISNNKKWILSASKDRTMRLWNIEE 394



 Score = 62.0 bits (149), Expect = 8e-10
 Identities = 31/83 (37%), Positives = 49/83 (59%), Gaps = 1/83 (1%)

Query: 57  APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
           A + L+ GHEG V  C F  + S L S GFDR + +W+V  +     +LKGH+  VM++ 
Sbjct: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV-AEGYRKLSLKGHNDWVMDVA 370

Query: 117 YNTDGSMLFSASTDKTVAVWDSE 139
            + +   + SAS D+T+ +W+ E
Sbjct: 371 ISNNKKWILSASKDRTMRLWNIE 393


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score =  115 bits (289), Expect = 5e-26
 Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)

Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
           ++ H+ AV    ++ DG  + S   DKT+ V+ +ETGE++  +K H   V  C       
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 669

Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
           + + T S D  VK+W+      + T+ +++ QV    F ++S  ++  +G  D  +K+WD
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729

Query: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
           L Q +   TM GH +SV     S +   L S + D T+++WD      ++   VK F  N
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789

Query: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
           + + ++++      CSWS DG++I   + ++ +++W+T SR  +    GH   ++ V F 
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 848

Query: 337 PDEPIIISASSDKRLYMGE 355
           PD    +++S D+ + + E
Sbjct: 849 PDGSSFLTSSDDQTIRLWE 867



 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117
           ++ +  HE EV CC F  +   +A+   D+ + +WN + G+  +  T   HS  V   H+
Sbjct: 650 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 707

Query: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173
                  +L + S+D  + +WD    E    + GHT+ VN C   R  P  +L+ + S D
Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 764

Query: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220
           GT+KLWD      RK   ++ F       Q   +V+    + ++D   I     N I +W
Sbjct: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 824

Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274
           +          RGH   V G+  S +GS  L+++ D T+R+W+ +          K+   
Sbjct: 825 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 884

Query: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
            +FQ N                        +  E  +  C  SP    IA G  +  + +
Sbjct: 885 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 944

Query: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            +  + RI      H  ++  + F  DE  +IS+S D  +
Sbjct: 945 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 984



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)

Query: 69   VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
            V CC +  +G+ +  A  ++ I LWN        A  +GH   V  + ++ DGS   ++S
Sbjct: 801  VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 858

Query: 129  TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155
             D+T+ +W+++                                R++ + G T  ++    
Sbjct: 859  DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 918

Query: 156  ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211
               SC       Q +  G ++G +++ ++      Q+ FQ+   V  + F      +IS 
Sbjct: 919  AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 978

Query: 212  GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
              D +I+VW+ + +K  + +RGH ++V    L  + S LLS + D TV+VW++     KE
Sbjct: 979  SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1035

Query: 272  RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
            +     QG V       L C  S D +K ++ SAD+   +W       L++L GH G + 
Sbjct: 1036 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1088

Query: 332  EVAFHPDEPIIISASSD 348
              AF  D  ++ +   +
Sbjct: 1089 CSAFSVDSTLLATGDDN 1105



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)

Query: 66   EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
            E +V CC   P+   +A    +  I +  +  +    +  + H   V  + +  D   L 
Sbjct: 918  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 976

Query: 126  SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
            S+S D  + VW+ +  + +  L+GH   V      +    L  + S DGTVK+W+I    
Sbjct: 977  SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1033

Query: 183  KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
            K+      Q T  VL+   +  + +  S   D   K+W        + +RGH   V   +
Sbjct: 1034 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1091

Query: 243  LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
             S + + L +   +  +R+W+V        C  + +         +    +SPDG  +  
Sbjct: 1092 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1150

Query: 303  GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
             SA  ++  W+  +         +  ++ ++   PD    ++  +   LY+
Sbjct: 1151 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)

Query: 55   LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
            L  P+  L GH G V C  F  + + LA+   +  I +WNV        C     +  AT
Sbjct: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132

Query: 105  LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
               H G V +L ++ DG ML SA     +  W+  TGE
Sbjct: 1133 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1165


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score =  115 bits (289), Expect = 5e-26
 Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)

Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
           ++ H+ AV    ++ DG  + S   DKT+ V+ +ETGE++  +K H   V  C       
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 658

Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
           + + T S D  VK+W+      + T+ +++ QV    F ++S  ++  +G  D  +K+WD
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718

Query: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
           L Q +   TM GH +SV     S +   L S + D T+++WD      ++   VK F  N
Sbjct: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778

Query: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
           + + ++++      CSWS DG++I   + ++ +++W+T SR  +    GH   ++ V F 
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 837

Query: 337 PDEPIIISASSDKRLYMGE 355
           PD    +++S D+ + + E
Sbjct: 838 PDGSSFLTSSDDQTIRLWE 856



 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117
           ++ +  HE EV CC F  +   +A+   D+ + +WN + G+  +  T   HS  V   H+
Sbjct: 639 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 696

Query: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173
                  +L + S+D  + +WD    E    + GHT+ VN C   R  P  +L+ + S D
Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 753

Query: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220
           GT+KLWD      RK   ++ F       Q   +V+    + ++D   I     N I +W
Sbjct: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 813

Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274
           +          RGH   V G+  S +GS  L+++ D T+R+W+ +          K+   
Sbjct: 814 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 873

Query: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
            +FQ N                        +  E  +  C  SP    IA G  +  + +
Sbjct: 874 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 933

Query: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            +  + RI      H  ++  + F  DE  +IS+S D  +
Sbjct: 934 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 973



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)

Query: 69   VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
            V CC +  +G+ +  A  ++ I LWN        A  +GH   V  + ++ DGS   ++S
Sbjct: 790  VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 847

Query: 129  TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155
             D+T+ +W+++                                R++ + G T  ++    
Sbjct: 848  DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 907

Query: 156  ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211
               SC       Q +  G ++G +++ ++      Q+ FQ+   V  + F      +IS 
Sbjct: 908  AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 967

Query: 212  GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
              D +I+VW+ + +K  + +RGH ++V    L  + S LLS + D TV+VW++     KE
Sbjct: 968  SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1024

Query: 272  RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
            +     QG V       L C  S D +K ++ SAD+   +W       L++L GH G + 
Sbjct: 1025 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1077

Query: 332  EVAFHPDEPIIISASSD 348
              AF  D  ++ +   +
Sbjct: 1078 CSAFSVDSTLLATGDDN 1094



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)

Query: 66   EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
            E +V CC   P+   +A    +  I +  +  +    +  + H   V  + +  D   L 
Sbjct: 907  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 965

Query: 126  SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
            S+S D  + VW+ +  + +  L+GH   V      +    L  + S DGTVK+W+I    
Sbjct: 966  SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1022

Query: 183  KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
            K+      Q T  VL+   +  + +  S   D   K+W        + +RGH   V   +
Sbjct: 1023 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080

Query: 243  LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
             S + + L +   +  +R+W+V        C  + +         +    +SPDG  +  
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1139

Query: 303  GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
             SA  ++  W+  +         +  ++ ++   PD    ++  +   LY+
Sbjct: 1140 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)

Query: 55   LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
            L  P+  L GH G V C  F  + + LA+   +  I +WNV        C     +  AT
Sbjct: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121

Query: 105  LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
               H G V +L ++ DG ML SA     +  W+  TGE
Sbjct: 1122 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1154


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  115 bits (288), Expect = 6e-26
 Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)

Query: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
           R   L++P  +L GH+  V  C     G+ + S   D  + +W+ V G C    TL GH+
Sbjct: 248 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 303

Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
           G V       +  ++ S STD+T+ VW++ETGE +  L GHTS V   +   +    V +
Sbjct: 304 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 358

Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
           GS D T+++WDI     +         +     D   +++SG  D  +KVWD       +
Sbjct: 359 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 417

Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
           T++GH + V   SL  +G +++S ++D ++RVWDV        C+    G+        L
Sbjct: 418 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 465

Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
                   + + +G+AD  V +WD  + + L  L G   H  ++  + F+ +   +I++S
Sbjct: 466 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 523

Query: 347 SDKRLYMGEIQ 357
            D  + + +++
Sbjct: 524 DDGTVKLWDLK 534



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
           I  L+GH+      +   N   L S   D  + +W++  G C    TL+G   H  AV  
Sbjct: 456 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 511

Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
           L +N +   + ++S D TV +WD +TGE ++ L
Sbjct: 512 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  115 bits (288), Expect = 6e-26
 Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)

Query: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
           R   L++P  +L GH+  V  C     G+ + S   D  + +W+ V G C    TL GH+
Sbjct: 366 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 421

Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
           G V       +  ++ S STD+T+ VW++ETGE +  L GHTS V   +   +    V +
Sbjct: 422 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 476

Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
           GS D T+++WDI     +         +     D   +++SG  D  +KVWD       +
Sbjct: 477 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 535

Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
           T++GH + V   SL  +G +++S ++D ++RVWDV        C+    G+        L
Sbjct: 536 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 583

Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
                   + + +G+AD  V +WD  + + L  L G   H  ++  + F+ +   +I++S
Sbjct: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 641

Query: 347 SDKRLYMGEIQ 357
            D  + + +++
Sbjct: 642 DDGTVKLWDLK 652



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
           I  L+GH+      +   N   L S   D  + +W++  G C    TL+G   H  AV  
Sbjct: 574 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 629

Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
           L +N +   + ++S D TV +WD +TGE ++ L
Sbjct: 630 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  115 bits (288), Expect = 6e-26
 Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)

Query: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
           R   L++P  +L GH+  V  C     G+ + S   D  + +W+ V G C    TL GH+
Sbjct: 286 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 341

Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
           G V       +  ++ S STD+T+ VW++ETGE +  L GHTS V   +   +    V +
Sbjct: 342 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 396

Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
           GS D T+++WDI     +         +     D   +++SG  D  +KVWD       +
Sbjct: 397 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 455

Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
           T++GH + V   SL  +G +++S ++D ++RVWDV        C+    G+        L
Sbjct: 456 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 503

Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
                   + + +G+AD  V +WD  + + L  L G   H  ++  + F+ +   +I++S
Sbjct: 504 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 561

Query: 347 SDKRLYMGEIQ 357
            D  + + +++
Sbjct: 562 DDGTVKLWDLK 572



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
           I  L+GH+      +   N   L S   D  + +W++  G C    TL+G   H  AV  
Sbjct: 494 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 549

Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
           L +N +   + ++S D TV +WD +TGE ++ L
Sbjct: 550 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  112 bits (279), Expect = 7e-25
 Identities = 65/206 (31%), Positives = 104/206 (50%), Gaps = 3/206 (1%)

Query: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
           +L GH G VY  +F  + S L S   D  I  W++ G   N    +GH+  V +L  +  
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-GSFTNTVLYQGHAYPVWDLDISPY 395

Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
                S S D+T  +W  +    ++   GH + V+ C         + TGS D TV+LW 
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD-CVKFHPNSNYLATGSTDKTVRLWS 454

Query: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
            ++  +++ F  +   VL++ F+     + S G D  +K+WDL    L   +RGH D++T
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514

Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVR 265
            L+ S +   + S +MDN+VRVWD+R
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIR 540



 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 76/285 (26%), Positives = 126/285 (44%), Gaps = 30/285 (10%)

Query: 79  STLASAGFDR-LILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137
           S L +AGFD   I LW++          + H   V  +H   D   +     D+     D
Sbjct: 280 SKLLAAGFDNSCIKLWSLRS---KKLKSEPHQVDVSRIHLACD---ILEEEDDE-----D 328

Query: 138 SETGERVKRLKGHTSFVNSC-YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQ 195
              G  +K L+GH   V S  + A     L C  S+D +++ WD+        +Q + Y 
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSC--SEDMSIRYWDLGSFTNTVLYQGHAYP 386

Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---GHADSVTGLSLSSEGSYLLS 252
           V  +  +  S    SG  D   ++W   +   TY +R   GH   V  +      +YL +
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDR---TYPLRIYAGHLADVDCVKFHPNSNYLAT 443

Query: 253 NAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
            + D TVR+W     A +   V++F G+       +L  ++SP+G  +A+   D+ + +W
Sbjct: 444 GSTDKTVRLWS----AQQGNSVRLFTGH----RGPVLSLAFSPNGKYLASAGEDQRLKLW 495

Query: 313 DTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
           D  S  +  +L GH  +I  + F PD  +I SAS D  + + +I+
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 43/126 (34%), Positives = 70/126 (55%), Gaps = 4/126 (3%)

Query: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
           P+ + +GH  +V C KFHPN + LA+   D+ + LW+     ++     GH G V+ L +
Sbjct: 418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ-QGNSVRLFTGHRGPVLSLAF 476

Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTV 176
           + +G  L SA  D+ + +WD  +G   K L+GHT  + S  +    G  L+ + S D +V
Sbjct: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSG--LIASASMDNSV 534

Query: 177 KLWDIR 182
           ++WDIR
Sbjct: 535 RVWDIR 540



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 9/186 (4%)

Query: 60  MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK---GHSGAVMELH 116
           +L  GH   V+     P     AS   DR   LW+     D    L+   GH   V  + 
Sbjct: 378 VLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSF----DRTYPLRIYAGHLADVDCVK 433

Query: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
           ++ + + L + STDKTV +W ++ G  V+   GH   V S   +  G  L   G D   +
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ-RL 492

Query: 177 KLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
           KLWD+      +  + +T  + ++TF+  S  I S  +DN ++VWD+R    +    G +
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSS 552

Query: 236 DSVTGL 241
             + G+
Sbjct: 553 SELVGV 558


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score =  108 bits (271), Expect = 6e-24
 Identities = 78/296 (26%), Positives = 132/296 (44%), Gaps = 9/296 (3%)

Query: 49  PPRCSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDCDNYATLKG 107
           P +C   +  I + SGH   V   +  P +G  L S   D  I LW VYG+     T  G
Sbjct: 271 PEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIG 330

Query: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH-TSFVNSCYPARRGPQL 166
           HS AV ++ +NT G+   SA+ D+ + +WD+ETG+ + R       +     P      L
Sbjct: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNL 390

Query: 167 VCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR-Q 224
              G  D  +  WDIR    +Q + ++   V  + F D + + +S   D  ++VW+    
Sbjct: 391 FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 450

Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR-PFAPKERCVKIFQGNVHN 283
               Y       S+  ++LS  G +L   +MDN + ++  +  F   ++  KIF+G  H 
Sbjct: 451 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKK--KIFKG--HM 506

Query: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
                 +  +SPD S + +G  +  + +WD  + ++  +   H        +HP E
Sbjct: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHE 562



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 13/152 (8%)

Query: 208 IISGGIDNDIKVWDLR-QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
           ++S  +D  IK+W++  + +   T  GH+ +V  +  ++ G+  LS A D  +++WD   
Sbjct: 304 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363

Query: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK---IAAGSADRFVYVWDTTSRRILYKL 323
                +C+  F        K      ++PD  K     AG +D+ +  WD  S  I+ + 
Sbjct: 364 ----GQCISRFTNR-----KVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEY 414

Query: 324 PGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
             H G++N + F  +    +S S DK L + E
Sbjct: 415 DRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 4/109 (3%)

Query: 76  PNGSTLASAGFDRLILLWNVYGD--CDNYATLKGH--SGAVMELHYNTDGSMLFSASTDK 131
           PNG  LA    D  IL++        +     KGH  +G   ++ ++ D S + S   + 
Sbjct: 471 PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNG 530

Query: 132 TVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
            + +WD +T +   R K H                V T   DG +KLWD
Sbjct: 531 KLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579


>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score =  108 bits (269), Expect = 1e-23
 Identities = 76/293 (25%), Positives = 138/293 (47%), Gaps = 15/293 (5%)

Query: 56  QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
           Q  +  L   +G V   +F+ +G+   + G D+ + LWN         T  GH   V++ 
Sbjct: 15  QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGT-LLRTYSGHGYEVLDA 73

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
             + D S L S   DK V +WD  +G+ V++ +GH   VN+         ++ +GS D +
Sbjct: 74  AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNT-VQFNEEATVILSGSIDSS 132

Query: 176 VKLWDIRKK--AAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
           ++ WD R +    +QT       V +V  +D   +I++G +D  ++ +DLR  +L     
Sbjct: 133 IRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDYV 190

Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292
           G    +T    S +G   L +++D+T+R+ D      K+    + +   H  ++  L C 
Sbjct: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLD------KDTGELLGEYKGHKNQEYKLDCC 242

Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
            S   + + + S D  V+ WD     +   LP  +G +  +A+HP EP +++A
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 32/115 (27%), Positives = 62/115 (53%), Gaps = 8/115 (6%)

Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
           +V  +  + +G+Y L+   D T+++W+      +   ++ + G  H +E  +L  + S D
Sbjct: 27  AVRAVRFNVDGNYCLTCGSDKTLKLWNPL----RGTLLRTYSG--HGYE--VLDAAGSFD 78

Query: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            S + +G  D+ V +WD  S +++ K  GHAG +N V F+ +  +I+S S D  +
Sbjct: 79  NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133


>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score =  108 bits (269), Expect = 1e-23
 Identities = 76/293 (25%), Positives = 138/293 (47%), Gaps = 15/293 (5%)

Query: 56  QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
           Q  +  L   +G V   +F+ +G+   + G D+ + LWN         T  GH   V++ 
Sbjct: 15  QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGT-LLRTYSGHGYEVLDA 73

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
             + D S L S   DK V +WD  +G+ V++ +GH   VN+         ++ +GS D +
Sbjct: 74  AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNT-VQFNEEATVILSGSIDSS 132

Query: 176 VKLWDIRKK--AAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
           ++ WD R +    +QT       V +V  +D   +I++G +D  ++ +DLR  +L     
Sbjct: 133 IRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDYV 190

Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292
           G    +T    S +G   L +++D+T+R+ D      K+    + +   H  ++  L C 
Sbjct: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLD------KDTGELLGEYKGHKNQEYKLDCC 242

Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
            S   + + + S D  V+ WD     +   LP  +G +  +A+HP EP +++A
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 32/115 (27%), Positives = 62/115 (53%), Gaps = 8/115 (6%)

Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
           +V  +  + +G+Y L+   D T+++W+      +   ++ + G  H +E  +L  + S D
Sbjct: 27  AVRAVRFNVDGNYCLTCGSDKTLKLWNPL----RGTLLRTYSG--HGYE--VLDAAGSFD 78

Query: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
            S + +G  D+ V +WD  S +++ K  GHAG +N V F+ +  +I+S S D  +
Sbjct: 79  NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  107 bits (267), Expect = 2e-23
 Identities = 84/304 (27%), Positives = 135/304 (44%), Gaps = 31/304 (10%)

Query: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
           L GH   V    F P G  LAS   D  +  W++  +  ++ T KGH   V+ + ++ DG
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHF-TCKGHRHWVLSISWSPDG 168

Query: 122 SMLFSASTDKTVAVWDSETGERVKR-LKGHTSFVN--SCYPARRGPQ--LVCTGSDDGTV 176
             L S   +  + +WD  TG++V R L GH+ ++   S  P    P+   V + S DG+V
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228

Query: 177 KLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
           ++WD       +      Q +          + S   D  IKVW      L  T++GH  
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288

Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV--KIFQGNVHNFEK------NL 288
            V  ++LS++  Y L               F P E  V  +  QG++   ++      NL
Sbjct: 289 WVNTMALSTD--YALRTG-----------AFEPAEASVNPQDLQGSLQELKERALSRYNL 335

Query: 289 LRCSWSPDGSKIAAGSADRFVYVWD-TTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
           +R        ++ +GS D  +++W     ++ L ++ GH   IN+V F PD  I+ SAS 
Sbjct: 336 VR---GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392

Query: 348 DKRL 351
           DK +
Sbjct: 393 DKSI 396



 Score =  104 bits (260), Expect = 1e-22
 Identities = 76/282 (26%), Positives = 128/282 (45%), Gaps = 55/282 (19%)

Query: 75  HPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
           +P    +AS+  D  + +W+   G C+   T  GH+ +V  L +  DG +L+SAS D+T+
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILT--GHTQSVTCLRWGGDG-LLYSASQDRTI 269

Query: 134 AVWDSETGERVKRLKGHTSFVNSC-----YPAR--------------------------- 161
            VW +  G   + L+GH  +VN+      Y  R                           
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERA 329

Query: 162 ---------RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLA--VTFNDTSDQIIS 210
                    +GP+ + +GSDD T+ LW   +     T    +Q L   V F+  S  + S
Sbjct: 330 LSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVAS 389

Query: 211 GGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270
              D  IK+WD R  K   ++RGH  +V  ++ S++   L+S + D+T++VWDV+     
Sbjct: 390 ASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----A 445

Query: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
           ++      G+       +    WSPDG ++A+G  D+ + +W
Sbjct: 446 QKLAMDLPGHA----DEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 37/113 (32%), Positives = 63/113 (55%), Gaps = 9/113 (7%)

Query: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
           + T ++ GH+++V  ++ S  G YL S + D TVR WD+    P   C    +G+ H   
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRH--- 157

Query: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWD-TTSRRILYKLPGHAGSINEVAFHP 337
             +L  SWSPDG K+A+G  +  + +WD +T +++   L GH+  I  +++ P
Sbjct: 158 -WVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 36/154 (23%), Positives = 66/154 (42%), Gaps = 11/154 (7%)

Query: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT-------GLSLSSEG 247
           Q L V F D   Q++    D  + +   R   +   +    D +           +SS G
Sbjct: 15  QRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLG 74

Query: 248 SYLLSNAMDNTVRVWDV--RPFAP-KERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGS 304
             L S A++ T +V D+  +P A  + R V     ++    + ++  ++SP G  +A+GS
Sbjct: 75  KTLESQAVE-TEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGS 133

Query: 305 ADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
            D  V  WD ++    +   GH   +  +++ PD
Sbjct: 134 GDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167



 Score = 33.5 bits (75), Expect = 0.30
 Identities = 14/34 (41%), Positives = 20/34 (58%)

Query: 60  MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
           M L GH  EVY   + P+G  +AS G D+ + +W
Sbjct: 450 MDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  106 bits (265), Expect = 3e-23
 Identities = 61/209 (29%), Positives = 103/209 (49%), Gaps = 9/209 (4%)

Query: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL---KGHSGAVMEL 115
           + +L GH G VY   F P+ + L S+  D  + LW++      +  L   KGH+  V + 
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTCLVGYKGHNYPVWDT 591

Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
            ++  G    S   D+   +W ++  + ++   GH + VN C         V TGS D T
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN-CTRFHPNSNYVATGSADRT 650

Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234
           V+LWD+     ++ F  +   + ++TF+     + +G  D  + +WD+    +   ++GH
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710

Query: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
            D+V  L  S +G  L S +MDNTVR+WD
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 53/156 (33%), Positives = 85/156 (54%), Gaps = 5/156 (3%)

Query: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELH 116
           P+ + +GH  +V C +FHPN + +A+   DR + LW+V  G+C    T  GH G +  L 
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT--GHKGPIHSLT 676

Query: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
           ++ +G  L + +TD  V +WD   G  V  LKGHT  V S   +R G +++ +GS D TV
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDG-EILASGSMDNTV 735

Query: 177 KLWD-IRKKAAIQTFQNTYQVLAVTFNDTSDQIISG 211
           +LWD I+    ++T   T     +   + S +++ G
Sbjct: 736 RLWDAIKAFEDLETDDFTTATGHINLPENSQELLLG 771



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 64/236 (27%), Positives = 108/236 (45%), Gaps = 20/236 (8%)

Query: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ--LVCTGSDDGTV 176
           +D S++   S D    + D +T   +K L GH+  V   Y A   P    + + S+DGTV
Sbjct: 511 SDLSLIDKESDDVLERIMDEKTASELKILYGHSGPV---YGASFSPDRNYLLSSSEDGTV 567

Query: 177 KLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
           +LW ++    +  ++ + Y V    F+      +SGG D   ++W     +      GH 
Sbjct: 568 RLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL 627

Query: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN---VHNFEKNLLRCS 292
             V         +Y+ + + D TVR+WDV        CV+IF G+   +H+        +
Sbjct: 628 ADVNCTRFHPNSNYVATGSADRTVRLWDVL----NGNCVRIFTGHKGPIHSL-------T 676

Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
           +SP+G  +A G+ D  V +WD     ++ +L GH  ++  + F  D  I+ S S D
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 55/210 (26%), Positives = 89/210 (42%), Gaps = 10/210 (4%)

Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
           L GHSG V    ++ D + L S+S D TV +W  +T   +   KGH   V     +  G 
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598

Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223
             V +G  D   +LW       ++ F  +   V    F+  S+ + +G  D  +++WD+ 
Sbjct: 599 YFV-SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657

Query: 224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
                    GH   +  L+ S  G +L + A D  V +WD+           +  G +  
Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH--------GLMVGELKG 709

Query: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
               +    +S DG  +A+GS D  V +WD
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 60/256 (23%), Positives = 114/256 (44%), Gaps = 22/256 (8%)

Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
           Y  L  + G +  +    D S++     D TV VW S T ++++ +K  +          
Sbjct: 464 YTFLNAYQG-LTAVDVTDDSSLIAGGFADSTVRVW-SVTPKKLRSVKQASDL-------- 513

Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
               L+   SDD   ++ D +  + ++  + ++  V   +F+   + ++S   D  +++W
Sbjct: 514 ---SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570

Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
            L+        +GH   V     S  G Y +S   D   R+W    + P    ++IF G 
Sbjct: 571 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP----LRIFAG- 625

Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
            H  + N  R  + P+ + +A GSADR V +WD  +   +    GH G I+ + F P+  
Sbjct: 626 -HLADVNCTR--FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682

Query: 341 IIISASSDKRLYMGEI 356
            + + ++D R+ + +I
Sbjct: 683 FLATGATDGRVLLWDI 698



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 19/129 (14%)

Query: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288
           YT       +T + ++ + S +     D+TVRVW V P                   K L
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTP-------------------KKL 504

Query: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
                + D S I   S D    + D  +   L  L GH+G +   +F PD   ++S+S D
Sbjct: 505 RSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSED 564

Query: 349 KRLYMGEIQ 357
             + +  +Q
Sbjct: 565 GTVRLWSLQ 573


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  105 bits (261), Expect = 8e-23
 Identities = 75/295 (25%), Positives = 144/295 (48%), Gaps = 31/295 (10%)

Query: 68  EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
           +V    ++  G+ LA+  +D    +W   G+  +  TL  H G +  L +N  G+ + SA
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIWTKDGNLAS--TLGQHKGPIFALKWNKKGNFILSA 284

Query: 128 STDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR----RGPQLVCTGSDDGTVKLWDIRK 183
             DKT  +WD+ TGE  ++   H++      PA     +      + S D  + +  + +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSA------PALDVDWQSNNTFASCSTDMCIHVCKLGQ 338

Query: 184 KAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
              I+TFQ +T +V A+ ++ T + + S   D  +K+W ++Q+   + ++ H   +  + 
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIK 398

Query: 243 LSSEGS---------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
            S  G           L S + D+TVR+WDV      +R + I     H  ++ +   ++
Sbjct: 399 WSPTGPGTNNPNANLMLASASFDSTVRLWDV------DRGICIHTLTKH--QEPVYSVAF 450

Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
           SPDG  +A+GS D+ V++W+T +  +++   G  G I EV ++     + +++SD
Sbjct: 451 SPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASD 504



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 49/176 (27%), Positives = 83/176 (47%), Gaps = 11/176 (6%)

Query: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
           PI    GH  EV   K+ P G+ LAS   D  + +W++  D +    L+ H+  +  + +
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD-NCVHDLQAHNKEIYTIKW 399

Query: 118 NTDGS---------MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
           +  G          ML SAS D TV +WD + G  +  L  H   V S   +  G + + 
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDG-RYLA 458

Query: 169 TGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
           +GS D  V +W+ +  A + +++ T  +  V +N   D++ +   D  + V DLR+
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/307 (26%), Positives = 143/307 (46%), Gaps = 28/307 (9%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           G +  +  C F PN   LA+A +  L  LW+V  DC+   TL+GH+  V  + ++   ++
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV-PDCNLLHTLRGHNTNVGAIVFHPKSTV 287

Query: 124 --------LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDD 173
                   L S + D +V +W  ++ E V  ++GHT  V     +P+ R     C    D
Sbjct: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY---D 344

Query: 174 GTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
            + +LWD+  +  I   + ++  V  + F+       +GG+D   +VWDLR  +    + 
Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404

Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR-C 291
           GH   + G++ S  G ++ + + DNT +VWD+R    + RCV     +     +NL+   
Sbjct: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR----QRRCVYTIPAH-----QNLVTGV 455

Query: 292 SWSP-DGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK- 349
            + P  G+ +  G+ D    +W       L  L GH G +  +    D  +I + S D+ 
Sbjct: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515

Query: 350 -RLYMGE 355
            +L+M E
Sbjct: 516 FKLWMAE 522



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 59/207 (28%), Positives = 99/207 (47%), Gaps = 4/207 (1%)

Query: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
           P+  + GH   V    +HP+G  L +  +DR   LW++    +     +GHS  V ++ +
Sbjct: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-EEILHQEGHSMGVYDIAF 373

Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
           + DGS+  +   D    VWD  TG  +  L+GH   +     +  G   + TGS D T K
Sbjct: 374 HQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH-IATGSGDNTCK 432

Query: 178 LWDIRKKAAIQTF-QNTYQVLAVTFNDT-SDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
           +WD+R++  + T   +   V  V F     + +++G  DN  K+W         T+ GH 
Sbjct: 433 VWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHE 492

Query: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVW 262
             V GL +SS+G  + + + D T ++W
Sbjct: 493 GKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 61/246 (24%), Positives = 107/246 (43%), Gaps = 16/246 (6%)

Query: 100 DNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY- 158
           +N+ +  G    +   H++ +  ML +A       +W       +  L+GH + V +   
Sbjct: 222 NNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF 281

Query: 159 ----PARRGPQLVCTGS--DDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISG 211
                    P+ V   S   DG+VKLW +     +   + +T +V  V ++ +   + + 
Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT 341

Query: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
             D   ++WDL   +      GH+  V  ++   +GS   +  +D   RVWD+R      
Sbjct: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR----TG 397

Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
           RC+   +G++    K +   ++SP+G  IA GS D    VWD   RR +Y +P H   + 
Sbjct: 398 RCIMFLEGHL----KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453

Query: 332 EVAFHP 337
            V F P
Sbjct: 454 GVKFEP 459



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 57  APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
           +P+  L+GHEG+V       +G  +A+  +DR   LW
Sbjct: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519


>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
           [Homo sapiens]
          Length = 2269

 Score =  103 bits (258), Expect = 2e-22
 Identities = 80/317 (25%), Positives = 148/317 (46%), Gaps = 26/317 (8%)

Query: 64  GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
           GH   VYC  F   G  + +   D L+ +W+ +      +TL+GHS  + ++  N + +M
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG-RLLSTLRGHSAEISDMAVNYENTM 242

Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQ--LVCTGSDDGTVKL- 178
           + + S DK + VW   T   V  L+GHT  + S    P  +G Q  +V TG+ DGTV   
Sbjct: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVCFW 301

Query: 179 -WDIRK-KAAIQTFQNT------YQVLAVTFNDTSDQIISGGIDNDIKVWDL--RQNKLT 228
            WD+   K + +  + T       Q+L  +F+     + +G  D+ I+++ L     +  
Sbjct: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361

Query: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI---FQGNVHNFE 285
             +  H D V  +   + G   LS + D T R+W       +   + +     G++ + E
Sbjct: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421

Query: 286 KNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP-DE 339
           +  ++      +W+ + S +     D  + VW++ + ++L+ L GHA  +  +  HP D 
Sbjct: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481

Query: 340 PIIISASSDKRLYMGEI 356
            I++SA  D  +++ +I
Sbjct: 482 RIMLSAGHDGSIFIWDI 498



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 71/328 (21%), Positives = 134/328 (40%), Gaps = 41/328 (12%)

Query: 52  CSSLQAPIMLLSGHEGEVYCCKFHP--NGST--LASAGFDRLILLWNVYGDCDNYA---- 103
           C    AP+ +L GH G +   +F P   GS   + S G D  +  W    +   ++    
Sbjct: 256 CLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPL 315

Query: 104 --TLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVW--DSETGERVKRLKGHTSFVNSCY 158
             T K   G  M    ++  G  L + STD  + ++    E  E++  L+ HT  V+S  
Sbjct: 316 KFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQ 375

Query: 159 PARRGPQLVCTGSDDGTVKLWDI--------------RKKAAIQTFQNTY---QVLAVTF 201
               G + + +GS DGT ++W                R    + + +  +   +V  + +
Sbjct: 376 FCNNGDRFL-SGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAW 434

Query: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVR 260
           N     +++   D+ +KVW+    +L + + GHAD V  L     +   +LS   D ++ 
Sbjct: 435 NQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIF 494

Query: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
           +WD+      +    + +G  H     +  C +S DG   A   +   + ++     +  
Sbjct: 495 IWDITKGTKMKHYFNMIEGQGHG---AVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPY 551

Query: 321 YKLPGHAGSINEVAFHPDEPIIISASSD 348
            K+P      +++ FH D   +I  S++
Sbjct: 552 EKIP------DQMFFHTDYRPLIRDSNN 573


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,898,340
Number of Sequences: 37866
Number of extensions: 700353
Number of successful extensions: 6568
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2089
Number of HSP's gapped (non-prelim): 1691
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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