Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 218505793

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
         (1677 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi...  3350   0.0  
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi...  3344   0.0  
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi...  2966   0.0  
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi...  2904   0.0  
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi...  2902   0.0  
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...  2897   0.0  
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi...  2895   0.0  
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi...  2886   0.0  
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi...  2845   0.0  
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...  2833   0.0  
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi...  2795   0.0  
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi...  1600   0.0  
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            343   1e-93
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            324   5e-88
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           314   4e-85
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   293   1e-78
gi|16933557 dachsous 1 precursor [Homo sapiens]                       291   3e-78
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      290   6e-78
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                       281   3e-75
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...   278   2e-74
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...   268   3e-71
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           266   1e-70
gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                      221   6e-57
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         206   1e-52
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        206   1e-52
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        198   3e-50
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        198   3e-50
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        198   3e-50
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   195   4e-49
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        195   4e-49

>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
          Length = 1677

 Score = 3350 bits (8687), Expect = 0.0
 Identities = 1677/1677 (100%), Positives = 1677/1677 (100%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440

Query: 1441 PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM 1500
            PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM
Sbjct: 1441 PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM 1500

Query: 1501 IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL 1560
            IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL
Sbjct: 1501 IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL 1560

Query: 1561 KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT 1620
            KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT
Sbjct: 1561 KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT 1620

Query: 1621 AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL 1677
            AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL
Sbjct: 1621 AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL 1677


>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
          Length = 1682

 Score = 3344 bits (8671), Expect = 0.0
 Identities = 1677/1682 (99%), Positives = 1677/1682 (99%), Gaps = 5/1682 (0%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
            MFRQFYLWTCLASGIILGSLFEICLGQYDDD     CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60

Query: 56   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
            LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120

Query: 116  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
            VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180

Query: 176  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
            ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240

Query: 236  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
            DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300

Query: 296  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
            NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360

Query: 356  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
            DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420

Query: 416  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
            DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480

Query: 476  TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
            TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481  TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540

Query: 536  ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
            ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541  ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600

Query: 596  NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
            NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601  NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
            DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720

Query: 716  VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
            VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721  VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780

Query: 776  KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 835
            KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781  KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840

Query: 836  TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 895
            TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841  TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900

Query: 896  VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 955
            VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901  VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960

Query: 956  PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
            PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961  PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020

Query: 1016 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
            MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080

Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
            EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140

Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
            DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200

Query: 1196 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1255
            VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260

Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1315
            PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320

Query: 1316 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1375
            QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380

Query: 1376 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1435
            ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440

Query: 1436 PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW 1495
            PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW 1500

Query: 1496 ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC 1555
            ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC
Sbjct: 1501 ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC 1560

Query: 1556 LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV 1615
            LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV
Sbjct: 1561 LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV 1620

Query: 1616 GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT 1675
            GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT
Sbjct: 1621 GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT 1680

Query: 1676 KL 1677
            KL
Sbjct: 1681 KL 1682


>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
          Length = 1790

 Score = 2966 bits (7689), Expect = 0.0
 Identities = 1497/1518 (98%), Positives = 1500/1518 (98%), Gaps = 12/1518 (0%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
            MFRQFYLWTCLASGIILGSLFEICLGQYDDD     CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60

Query: 56   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
            LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120

Query: 116  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
            VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180

Query: 176  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
            ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240

Query: 236  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
            DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300

Query: 296  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
            NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360

Query: 356  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
            DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420

Query: 416  DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
            DSLNLTSPLRIVALDKDIED       TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421  DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480

Query: 469  VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
            VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481  VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540

Query: 529  IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
            IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541  IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600

Query: 589  APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
            APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 601  APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660

Query: 649  TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
            TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 661  TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720

Query: 709  DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
            DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721  DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780

Query: 769  GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
            GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781  GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840

Query: 829  EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
            EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841  EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900

Query: 889  EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
            EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901  EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960

Query: 949  YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
            YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961  YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020

Query: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
            FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080

Query: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
            YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140

Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
            KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200

Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
            KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260

Query: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
            QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320

Query: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
            TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380

Query: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
            SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440

Query: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1488
            PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500

Query: 1489 EYEEEEWARKRMIKLVVD 1506
            EYEEEE   K++ K  V+
Sbjct: 1501 EYEEEEEEPKKIKKPKVE 1518


>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
          Length = 1539

 Score = 2904 bits (7527), Expect = 0.0
 Identities = 1458/1458 (100%), Positives = 1458/1458 (100%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440

Query: 1441 PPPGAHLYEELGDSSMHK 1458
            PPPGAHLYEELGDSSMHK
Sbjct: 1441 PPPGAHLYEELGDSSMHK 1458


>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
          Length = 1957

 Score = 2902 bits (7522), Expect = 0.0
 Identities = 1457/1457 (100%), Positives = 1457/1457 (100%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440

Query: 1441 PPPGAHLYEELGDSSMH 1457
            PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1807 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1835


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score = 2897 bits (7510), Expect = 0.0
 Identities = 1455/1456 (99%), Positives = 1456/1456 (100%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440

Query: 1441 PPPGAHLYEELGDSSM 1456
            PPPGAHLYEELGDSS+
Sbjct: 1441 PPPGAHLYEELGDSSI 1456



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1805 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1833


>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
          Length = 1962

 Score = 2895 bits (7506), Expect = 0.0
 Identities = 1457/1462 (99%), Positives = 1457/1462 (99%), Gaps = 5/1462 (0%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
            MFRQFYLWTCLASGIILGSLFEICLGQYDDD     CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60

Query: 56   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
            LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61   LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120

Query: 116  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
            VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180

Query: 176  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
            ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240

Query: 236  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
            DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241  DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300

Query: 296  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
            NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360

Query: 356  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
            DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361  DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420

Query: 416  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
            DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480

Query: 476  TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
            TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481  TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540

Query: 536  ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
            ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541  ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600

Query: 596  NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
            NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601  NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
            DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720

Query: 716  VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
            VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721  VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780

Query: 776  KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 835
            KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781  KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840

Query: 836  TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 895
            TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841  TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900

Query: 896  VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 955
            VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901  VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960

Query: 956  PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
            PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961  PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020

Query: 1016 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
            MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080

Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
            EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140

Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
            DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200

Query: 1196 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1255
            VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260

Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1315
            PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320

Query: 1316 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1375
            QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380

Query: 1376 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1435
            ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440

Query: 1436 PPPPPPPPGAHLYEELGDSSMH 1457
            PPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMH 1462



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1812 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1840


>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
          Length = 1952

 Score = 2886 bits (7481), Expect = 0.0
 Identities = 1452/1456 (99%), Positives = 1453/1456 (99%), Gaps = 3/1456 (0%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQ   RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1437

Query: 1441 PPPGAHLYEELGDSSM 1456
            PPPGAHLYEELGDSS+
Sbjct: 1438 PPPGAHLYEELGDSSI 1453



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1802 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1830


>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
          Length = 1935

 Score = 2845 bits (7374), Expect = 0.0
 Identities = 1435/1457 (98%), Positives = 1435/1457 (98%), Gaps = 22/1457 (1%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDD                      GTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99   INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999  TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418

Query: 1441 PPPGAHLYEELGDSSMH 1457
            PPPGAHLYEELGDSSMH
Sbjct: 1419 PPPGAHLYEELGDSSMH 1435



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1785 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1813


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score = 2833 bits (7345), Expect = 0.0
 Identities = 1432/1457 (98%), Positives = 1432/1457 (98%), Gaps = 25/1457 (1%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDD                      GTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99   INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999  TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQ   RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1415

Query: 1441 PPPGAHLYEELGDSSMH 1457
            PPPGAHLYEELGDSSMH
Sbjct: 1416 PPPGAHLYEELGDSSMH 1432



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1782 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1810


>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
          Length = 1915

 Score = 2795 bits (7245), Expect = 0.0
 Identities = 1415/1456 (97%), Positives = 1416/1456 (97%), Gaps = 40/1456 (2%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDP                                     DRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 204  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 264  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 324  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 384  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 444  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 504  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
            VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 564  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
            FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 624  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683

Query: 721  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
            LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 684  LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743

Query: 781  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
            VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 744  VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803

Query: 841  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
            IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 804  IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863

Query: 901  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
            IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 864  IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923

Query: 961  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
            SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 924  SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
            TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 984  TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
            TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223

Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
            EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283

Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
            IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343

Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
            AFIIILCCIPAILVVLVSYRQ   RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400

Query: 1441 PPPGAHLYEELGDSSM 1456
            PPPGAHLYEELGDSS+
Sbjct: 1401 PPPGAHLYEELGDSSI 1416



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1765 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1793


>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
          Length = 1886

 Score = 1600 bits (4142), Expect = 0.0
 Identities = 873/1184 (73%), Positives = 947/1184 (79%), Gaps = 78/1184 (6%)

Query: 344  TAELSLLEPVNRDFHQKFDLVIKAE---QDNGHPLPAFAGLHIEILDENNQSPYFT---- 396
            T  + L + +N +   ++ ++I+A    Q+          L +++LD ++  P F     
Sbjct: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270

Query: 397  MPSYQG---YILESAPVGATISDSLN---LTSPLRIVALDKDIEDTKDPELHLFL----- 445
            +P+ +       ++A       + LN   +T P++ +  D++I+   D    L+      
Sbjct: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330

Query: 446  -NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDA 502
              DY   F +     T  L+LL+PV+R+  Q +   I A        P    ++I+++D 
Sbjct: 331  PEDYPRFFHMHPR--TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 388

Query: 503  NDNTPTFPEISYDVYVYTDMRPGDSV---------IQLTAVDAD-EGSNGEITYEILVGA 552
            N+ +P F   SY  Y+      G ++         +++ A+D D E +     +  L   
Sbjct: 389  NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448

Query: 553  QGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 610
               F + +T  T  +T+   V+    +TY  ++ A D    +E       V I+V+  N+
Sbjct: 449  TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDAND 504

Query: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 667
             +P  FP++ Y + +   MR G  ++ L A D +  S   ITY I  G  Q  F +++TT
Sbjct: 505  NTPT-FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT 562

Query: 668  G----------------------------------ILTLGKALDRESTDRYILIITASDG 693
            G                                  ILTLGKALDRESTDRYILIITASDG
Sbjct: 563  GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG 622

Query: 694  RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
            RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH
Sbjct: 623  RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 682

Query: 754  YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
            YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID
Sbjct: 683  YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742

Query: 814  DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
            DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE
Sbjct: 743  DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802

Query: 874  LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
            LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG
Sbjct: 803  LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 862

Query: 934  MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
            MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN
Sbjct: 863  MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922

Query: 994  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
            LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT
Sbjct: 923  LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 982

Query: 1054 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1113
            MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE
Sbjct: 983  MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1042

Query: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
            VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT
Sbjct: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102

Query: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
            GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS
Sbjct: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162

Query: 1234 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1293
            GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR
Sbjct: 1163 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1222

Query: 1294 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1353
            HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE
Sbjct: 1223 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1282

Query: 1354 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1413
            IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA
Sbjct: 1283 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1342

Query: 1414 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1457
            RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1343 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1386



 Score = 1263 bits (3268), Expect = 0.0
 Identities = 726/1134 (64%), Positives = 804/1134 (70%), Gaps = 87/1134 (7%)

Query: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
            MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1    MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60

Query: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
            LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61   LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120

Query: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
            INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121  INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180

Query: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
            DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181  DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240

Query: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
            LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241  LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300

Query: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
            TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301  TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360

Query: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
            FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361  FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480

Query: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
            ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481  ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI-- 598
            NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER   I  
Sbjct: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600

Query: 599  -----------------------------CTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
                                          TV I V   N+ +P   P L  +L + E  
Sbjct: 601  LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE- 659

Query: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
               A +  ++ATD +      + Y++  G+   +F ++    I T  K L+RE  D Y L
Sbjct: 660  EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYEL 716

Query: 687  IITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 745
            ++ A+DG      ST T+ I V D++DN+PVF       L      A   + Q++A D D
Sbjct: 717  VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776

Query: 746  AGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE----LVVVATD--GAVHP 798
             G N           + F +    G +     L+ E     E     +V A D  G + P
Sbjct: 777  LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836

Query: 799  RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD----LGANVSY 854
              +T+T+ +K  D++D  PVF+   Y  +V  +   GT I  + A+D D      + V Y
Sbjct: 837  GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894

Query: 855  R---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 911
            R   ++ P     F +   +G +    +L+ E           +V AFD    +    AT
Sbjct: 895  RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLVVVAFDDGEPVMSSSAT 950

Query: 912  VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 971
            V ++V    + P    +      V+  A KGT +  + A  A    +  S V    +D  
Sbjct: 951  VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AINQSIVYSIVSGNEEDT- 1008

Query: 972  FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM------SSSATVKIL 1025
                   F +   +G +     L+ E  T + L V A D  E V+      S S T K+ 
Sbjct: 1009 -------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVY 1060

Query: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1079
            +    EI    Q+E   PPV +   K  + GV   A +  S++   V   ++DT
Sbjct: 1061 I----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR--VKATDKDT 1102



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)

Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
            P   P +P P P   PPPPP    PPPP A
Sbjct: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  343 bits (879), Expect = 1e-93
 Identities = 319/1192 (26%), Positives = 533/1192 (44%), Gaps = 135/1192 (11%)

Query: 99   TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
            T  +LDR+    ++  +V V  I K          EV I ++D NDN P F  +    TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749

Query: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
             E    G+ I         A D D+G N  + Y I    DD    D        +G+++ 
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDPE------SGDLIA 1798

Query: 217  RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
             +RL+ E +++Y ++++A+D  Q+ + R      + + V D +D  P F           
Sbjct: 1799 TRRLDRERRSKYSLLVRADDGLQSSDMR------INITVSDVNDHTPKF----------- 1841

Query: 277  CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
             RP+ Y   IPE   P  L   I+     A D D  +        I Y +     +D   
Sbjct: 1842 SRPV-YSFDIPEDTIPGSLVAAIL-----ATDDDSGVNGE-----ITYIV---NEDDEDG 1887

Query: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
             F ++P T   +L   ++ +  Q + L ++AE   G        ++  ILD N+  P F+
Sbjct: 1888 IFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTI--RVYFNILDVNDNPPIFS 1945

Query: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL--NDYTSVFTV 454
            + SY   ++E+ PVG+T+    N+T          D +D  + +L   +   D    FTV
Sbjct: 1946 LNSYSTSLMENLPVGSTVL-VFNVT----------DADDGINSQLTYSIASGDSLGQFTV 1994

Query: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE-----SEPVIVNIQVMDANDNTPTF 509
             + G+   L +L+ +DRE Q  Y   +   D  Q      +    V+I ++D NDN PTF
Sbjct: 1995 DKNGV---LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051

Query: 510  --PEISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
              P+++Y      +  P D+V+ +  A D D G N  I Y +L      F I    G + 
Sbjct: 2052 LSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107

Query: 567  IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
            +   ++      Y LTV A D   P+   ++   V +  +  NN   P F Q +Y +EI+
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN---PIFAQALYKVEIN 2164

Query: 627  EAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDR 683
            E    G  ++ + A D +      + Y I NG+  + F +   TG +T+ K LDRE T  
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPT 2224

Query: 684  YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD--PY---LPRNLSVVEEEANAFVG 737
            Y L + A+D G    T T+TV+IV+ D+ND  PVF+  PY   +P NL  +       + 
Sbjct: 2225 YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT----IL 2280

Query: 738  QVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
            QV A D D G N ++ Y L  GN +N F ++++G +     L+RE ++ + L++ ATD  
Sbjct: 2281 QVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSG 2340

Query: 796  VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855
                  T T+ + V D++DN P F +  Y   + E+ P GT +L + A D D   N   R
Sbjct: 2341 SPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR 2400

Query: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTV 914
            I     +  F ++P TG++     LD E     + + T +V   D     P   +T V V
Sbjct: 2401 IIGGNSQ--FTINPSTGQIITSALLDRET----KDNYTLVVVCSDAGSPEPLSSSTSVLV 2454

Query: 915  IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
             V D+ND PP F    Y   +    + G+ +  V   DAD    P S + Y +       
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLSGRN--- 2509

Query: 975  PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPR 1034
             +  F ++   G ++    LN      F + V   D G    + S TV +  ++  + P+
Sbjct: 2510 -SEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKADFPK 2566

Query: 1035 FTQEEY-----RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1089
               +E         PVS L T      +  ++   + + Y I SGN  +TF I+ +TG +
Sbjct: 2567 VRAKEQTFMFPENQPVSSLVTT-----ITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQV 2621

Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
             ++ PLD+E    YV+ ++A        +   P  S+  K+ I + D N++ P+F++  +
Sbjct: 2622 SISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPF 2674

Query: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
            I  + E+      +L V A DKD+G    + Y ++   +   +  F +   TG I++   
Sbjct: 2675 ISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNM---ENSFSINHATGEIRSVRP 2730

Query: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD-----MQVIVSNVP 1256
                + S++   + ++D      S    V+++++++ D      Q+  ++VP
Sbjct: 2731 LDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782



 Score =  331 bits (849), Expect = 3e-90
 Identities = 298/1109 (26%), Positives = 500/1109 (45%), Gaps = 88/1109 (7%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            I V D ND+ P F  + Y   ++E  P G+ + +G S    ATD D G N  + Y I   
Sbjct: 463  IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV-SGIS----ATDGDSGLNANLRYSIVSG 517

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                  + +    L+ TG+      L+ E  ++  + I A D+  +    + +   L V 
Sbjct: 518  NGLGWFHISEHSGLVTTGS---SGGLDRELASQIVLNISARDQGVH---PKVSYAQLVVT 571

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            +LD +D  P+F            +P  Y  ++ E   P     ++    ++A D D    
Sbjct: 572  LLDVNDEKPVF-----------SQPEGYDVSVVE-NAPTGTELLM----LRATDGDLG-- 613

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
               D   + +S+     E   R F + P +  LS +  ++R+    + L++ A      P
Sbjct: 614  ---DNGTVRFSLQEA--ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPP 668

Query: 375  LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
              + A +++ +LD N+ SP F    Y  +I E+ P G+ I+          + A D D+ 
Sbjct: 669  QSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---------VSATDPDLG 719

Query: 435  DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEP 492
                 +  +   D +      Q+G+   ++    +DREE+  Y   I A DG  +Q    
Sbjct: 720  TNGTVKYSISAGDRSRFQVNAQSGV---ISTRMALDREEKTAYQLQIVATDGGNLQSPNQ 776

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
             IV I V+D  DN P F +++Y   V+ ++  G  V  ++A   D  SN  I+Y I  G 
Sbjct: 777  AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTGD 834

Query: 553  Q-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQ 611
            Q G F IN+ TG +T A  ++      Y L V A+      +   +I    +      N 
Sbjct: 835  QKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDL------ND 888

Query: 612  SPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTG 668
            + P F Q + S+ + E  + G  +   +A D +      + Y+++  +P+ +F ++E  G
Sbjct: 889  NSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNG 947

Query: 669  ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 728
             ++L   LD  +    I I+ +  G P  +S+  + + V DVNDN+PVFD          
Sbjct: 948  TISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSE 1007

Query: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786
             E  N+   +V+A+D D+G NG++ Y++  GN  + F I  +G +Y   +L+RE++D Y 
Sbjct: 1008 SEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYV 1067

Query: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
            L+VVA+D AV P  +T+ + + + D++DN P+F ++ YT   EE   AG+ + ++ A D 
Sbjct: 1068 LMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDK 1127

Query: 847  DLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
            D G N   R     V+  F LH  +GE++     D E+   +  +  F          +P
Sbjct: 1128 DFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP 1187

Query: 907  PGI---ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPAS 961
              +   ATV V +KD+ND  P F K  Y+  ++  A   T +  V A D D    GL   
Sbjct: 1188 QPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHY 1247

Query: 962  RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
             +    ++ Q       F ++  SG+V     L+ E T  + LV+ A D G   ++S+ T
Sbjct: 1248 SIIKGNEERQ-------FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCT 1300

Query: 1022 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1077
            + I +L   +      +      V E    G +V  ++A    +  N  + YSI   N  
Sbjct: 1301 LNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNH 1360

Query: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
             TF I+  TG I++   LD+ET++ Y L + A        +   P +S+T  V I ++D 
Sbjct: 1361 GTFSISPNTGSIFLAKKLDFETQSLYKLNITA-------KDQGRPPRSSTMSVVIHVRDF 1413

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
            N++PP F        + E+  + TSV+ V A D D      ++Y  II  +  G   F +
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPRGNH-FTI 1471

Query: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
            +   G I T         + F+  V A D
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKAND 1500



 Score =  298 bits (764), Expect = 2e-80
 Identities = 309/1151 (26%), Positives = 507/1151 (44%), Gaps = 143/1151 (12%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            EVR++VRD NDN+P F   S   T  E +  G  +       + ATD D G NG      
Sbjct: 120  EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVIL-----DTATDSDIGSNGVDHRSY 174

Query: 192  QYNPDDPTSNDTFEIPLMLTG-----NIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
            +    +       +I L  +G     ++V +  L+ E   +Y ++++  D+ +    +R 
Sbjct: 175  RIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGE---PKRR 231

Query: 247  TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
                + V V D +D  P+F                YQA +PE       + ++ +  +Q 
Sbjct: 232  GYLQVNVTVQDINDNPPVF------------GSSHYQAGVPE-------DAVVGSSVLQV 272

Query: 307  IDQDRNIQPPSDRPGILYSIL-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
               D +    +D   I Y +   GTP      F M P T  +++ EP++ +  +++ L +
Sbjct: 273  AAADADEGTNAD---IRYRLQDEGTP------FQMDPETGLITVREPLDFEARRQYSLTV 323

Query: 366  KAEQDNGHP-LPAFAGLHIEILDENNQSP-----YFTMPSYQGYILESAPVGATI----- 414
            +A  D G P L   A   I++LD N+  P     YF   S    + E+A VG  +     
Sbjct: 324  QA-MDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382

Query: 415  ----SDSLNLTSPLRIVALDK----DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
                S + N    ++I+  ++    +++ +K P L L                   + + 
Sbjct: 383  TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL-------------------IKVA 423

Query: 467  QPVDREEQQTYTFSITAFDGV---------QESEPVIVNIQVMDANDNTPTFPEISYDVY 517
              +DRE   +Y  +++  D             S    + I V D ND+ P F +  Y V 
Sbjct: 424  SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483

Query: 518  VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI--APGVEMI 574
            +  +  PG  V  ++A D D G N  + Y I+ G   G F I++ +GL+T   + G++  
Sbjct: 484  LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543

Query: 575  VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
            +     L + A D       + S   + + +L  N++ P       Y + + E    G  
Sbjct: 544  LASQIVLNISARDQG--VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTE 601

Query: 635  LLNLQATDRE-GD--SITYAIENGD-PQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
            LL L+ATD + GD  ++ ++++  +  +R F L   +G L+   +LDRE    Y L++ A
Sbjct: 602  LLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLA 661

Query: 691  SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 749
            +D G P  +S A +N+ + D+NDN+PVF P          E   +++  V ATDPD G N
Sbjct: 662  TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721

Query: 750  GQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAI 807
            G V YS+  G+ +       +G I T + L+RE +  Y+L +VATDG      +   + I
Sbjct: 722  GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781

Query: 808  KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
             VLD  DN PVF+   Y+ +V EN+  G  +  + A  +DL +N+SY I + + K  FA+
Sbjct: 782  TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAI 841

Query: 868  HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
            +  TG+L+    +      D+E    + ++     GT+  G   V + VKD+ND  P F 
Sbjct: 842  NQVTGQLTTANVI------DREEQSFYQLKVVASGGTV-TGDTMVNITVKDLNDNSPHFL 894

Query: 928  KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
            + I    V  +   G  I    A+  DP       V Y +       P ++F + E +G 
Sbjct: 895  QAIESVNVVENWQAGHSI--FQAKAVDPDEGVNGMVLYSLKQ----NPKNLFAINEKNGT 948

Query: 988  VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS 1046
            +     L+    + +++ ++A D G P +SSS  + + V    +  P F Q  Y    +S
Sbjct: 949  ISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE-VTLS 1006

Query: 1047 ELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
            E     +    + A    +  N  I Y+I  GN  D FGI    G +Y+   LD E +  
Sbjct: 1007 ESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDR 1065

Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
            YVL        VV ++  V   S T  V + ++D N++ P+F    Y     E+ R  + 
Sbjct: 1066 YVLM-------VVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSF 1118

Query: 1163 VLRVKATDKDTGNYSVMAYRL-IIPPIKEGKEGFVVETYTGLIKTAMLFHN---MRR--- 1215
            V +V A DKD G    + Y   ++ P       F +   +G I     F     MRR   
Sbjct: 1119 VGKVSAVDKDFGPNGEVRYSFEMVQP------DFELHAISGEITNTHQFDRESLMRRRGT 1172

Query: 1216 SYFKFQVIATD 1226
            + F F VIATD
Sbjct: 1173 AVFSFTVIATD 1183



 Score =  288 bits (737), Expect = 3e-77
 Identities = 286/1073 (26%), Positives = 476/1073 (44%), Gaps = 100/1073 (9%)

Query: 202  DTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDL 261
            +TF+I   LTG + + + L++E   +Y V I+A D         ++   L + VLD +D 
Sbjct: 2610 NTFQID-QLTGQVSISQPLDFEKIQKYVVWIEARDGGF---PPFSSYEKLDITVLDVNDN 2665

Query: 262  GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG 321
             P+F            +   + + I E  +P +    I+T  + A+D+D       D   
Sbjct: 2666 APIF------------KEDPFISEILENLSPRK----ILT--VSAMDKDSGPNGQLD--- 2704

Query: 322  ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL 381
              Y I+ G  E+    F ++  T E+  + P++R+    + L IK+             +
Sbjct: 2705 --YEIVNGNMENS---FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKV 2759

Query: 382  HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 441
             I ILDEN+ +P F+   +  ++ E++P+G T++         R+   D+DI        
Sbjct: 2760 MINILDENDNAPRFSQ-IFSAHVPENSPLGYTVT---------RVTTSDEDIGINAISRY 2809

Query: 442  HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 501
             +   D +  FT+  +  T  + + +P++RE+   Y   ++A D    +    V I V D
Sbjct: 2810 SIM--DASLPFTINPS--TGDIVISRPLNREDTDRYRIRVSAHDSGW-TVSTDVTIFVTD 2864

Query: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INK 560
             NDN P F   SY +        G  V Q+ A D DEGSNG++ Y   + +Q ++  IN 
Sbjct: 2865 INDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY--FIKSQSEYFRINA 2922

Query: 561  TTGLI--------TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 612
            TTG I            G   +    ++  V ++D   P+    +  T+ I     +N +
Sbjct: 2923 TTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV---DSNDN 2979

Query: 613  PPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTG 668
             P+F +  Y   +++ ++VG  L+ + A D +       + Y I N +    F L   TG
Sbjct: 2980 APQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTG 3039

Query: 669  ILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 727
             +++  +L  +    + + +TA D G P  +S ATV+I VT+ N + P F          
Sbjct: 3040 WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099

Query: 728  VEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDY 784
                  + V  V A D DA +NG + YS+  GN   +F I S+  I T  K L+ E+   
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159

Query: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
            +E+ + A DG    R    ++ + V+D++DNSPVF +  Y   V EN P+GTT++ + A 
Sbjct: 3160 HEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNAT 3219

Query: 845  DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 902
            D D G N  ++Y ++S +    F + P TG ++    LD+E     + S    V+AF++ 
Sbjct: 3220 DADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET----KQSYHLTVKAFNVP 3274

Query: 903  GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASR 962
                   ATV + +K  N+Y P F  ++Y   ++  A KGT +  V+A D D        
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG--TDGE 3332

Query: 963  VRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA--FDDGEPVMSSSA 1020
            V Y +           F++ + +G++     L+ E      L V+A  F           
Sbjct: 3333 VHYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEV 3389

Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-----QSIVYSIVSGN 1075
            TV + VL   + P FT   Y    +SE    GT V  +SA   +         Y I SGN
Sbjct: 3390 TVNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGN 3448

Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
            E   F IN  TG I V   LD ET   Y       +L V+  +   PS + +A + + ++
Sbjct: 3449 ENGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAVDSGTPSATGSASLLVTLE 3501

Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNYSVMAYRLIIPPIKEGKEG 1194
            D N++ P+       G V E+ R  T V+ +++TD D   N     Y L+          
Sbjct: 3502 DINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL--STGPATSY 3557

Query: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
            F + T  G++ T       + + F   V+  D     +S    V ++V++Q D
Sbjct: 3558 FSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609



 Score =  283 bits (724), Expect = 1e-75
 Identities = 267/925 (28%), Positives = 409/925 (44%), Gaps = 83/925 (8%)

Query: 381  LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD-KDIEDTKDP 439
            + + + D N+ +P F  PS      E +  G  +       S +    +D +     +  
Sbjct: 121  VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180

Query: 440  ELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP----- 492
            E   F  D     T+  +G   +L L+    +DRE    Y   +   D   + EP     
Sbjct: 181  EAGRFRLD----ITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGY 233

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            + VN+ V D NDN P F    Y   V  D   G SV+Q+ A DADEG+N +I Y  L   
Sbjct: 234  LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDE 292

Query: 553  QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 612
               F ++  TGLIT+   ++    R Y+LTVQA D   P+          I++L  N+  
Sbjct: 293  GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEALIQLLDVNDND 350

Query: 613  P----PRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLS 664
            P      FP       + E  +VG V+  L  TD +      +I+  I  G+ QR F + 
Sbjct: 351  PVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQ 410

Query: 665  ET----TGILTLGKALDRESTDRYILIITASD--GRPDG------TSTATVNIVVTDVND 712
             +      ++ +  ALDRE    Y L ++ SD  G P G      +S A++ I V D+ND
Sbjct: 411  SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIND 470

Query: 713  NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGS 770
            + PVF   + R     E    ++V  + ATD D+G+N  + YS+ + N L  F I+ +  
Sbjct: 471  HPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530

Query: 771  IYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 826
            + T      L+RE+     L + A D  VHP+ S   L + +LD++D  PVF+    Y V
Sbjct: 531  LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590

Query: 827  LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSLLRSLDYE 883
             V EN P GT +L + A D DLG N + R    E    +  F L P +G LS + SLD E
Sbjct: 591  SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
                ++A  + LV A D+       +A + V + D+ND  PVF    Y   +  +   G+
Sbjct: 651  ----EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGS 706

Query: 944  PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
             ITTV A D D        V+Y +         S F+V   SG + TR+ L+ E  T ++
Sbjct: 707  YITTVSATDPDLG--TNGTVKYSIS----AGDRSRFQVNAQSGVISTRMALDREEKTAYQ 760

Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1062
            L +VA D G     + A V I VL   + P    +      V E    G  VG +SA+  
Sbjct: 761  LQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTM 820

Query: 1063 -INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1121
             +N +I Y I +G+++  F IN +TG +     +D E ++ Y L+V A    V       
Sbjct: 821  DLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV------- 873

Query: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1181
               +    V I ++D N++ P F +      V E+ +   S+ + KA D D G   ++ Y
Sbjct: 874  ---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLY 930

Query: 1182 RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV- 1240
             L   P    K  F +    G I       ++    ++ +++A+D     LS    + V 
Sbjct: 931  SLKQNP----KNLFAINEKNGTISLLGPL-DVHAGSYQIEILASDMGVPQLSSSVILTVY 985

Query: 1241 --------SVVNQLDMQVIVSNVPP 1257
                     V +QL  +V +S   P
Sbjct: 986  VHDVNDNSPVFDQLSYEVTLSESEP 1010



 Score =  268 bits (686), Expect = 3e-71
 Identities = 283/1042 (27%), Positives = 475/1042 (45%), Gaps = 112/1042 (10%)

Query: 130  YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
            Y ++ I V D NDN+P FK + + + + E L+P    I T       A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704

Query: 189  YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
            Y I     +    ++F I    TG I   + L+ E  + Y + I+++D+    +  ++T+
Sbjct: 2705 YEIV----NGNMENSFSIN-HATGEIRSVRPLDREKVSHYVLTIKSSDKG---SPSQSTS 2756

Query: 249  TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
              + +++LD +D  P F                + A +PE  +P       VT      D
Sbjct: 2757 VKVMINILDENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----D 2798

Query: 309  QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
            +D  I   S      YSI+     D    F ++P T ++ +  P+NR+   ++ + + A 
Sbjct: 2799 EDIGINAISR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848

Query: 369  QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
             D+G  +     + I + D N+ +P F+  SY     E   +G+ ++         ++ A
Sbjct: 2849 -DSGWTVST--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFA 2896

Query: 429  LDKDIEDTKDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQTYTFSIT 482
             D D  +  + ++  F+   +  F +  T      + +   Q V          ++F +T
Sbjct: 2897 TDPD--EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954

Query: 483  AFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEG 539
            + D  + S      V I ++D+NDN P F +  Y   V  +++ G  +I++TA+D  D G
Sbjct: 2955 SSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFG 3014

Query: 540  SNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 598
             N E+ Y I      G F ++  TG I++A  +   + + + +TV A D   P    +S 
Sbjct: 3015 LNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQ 3072

Query: 599  CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENG 655
             TV+I V   N  +P  F Q   S  I E+  +G+++  + A DR+      I Y+I +G
Sbjct: 3073 ATVHITVTEENYHTP-EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSG 3131

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVND 712
            + + +F ++ +TGILTL KALD E   ++ + I+A DG      G  + TVN++  DVND
Sbjct: 3132 NEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVND 3189

Query: 713  NAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN- 768
            N+PVF  D Y P  L      +   V  + ATD D+G N  + Y++  + ++LF I  N 
Sbjct: 3190 NSPVFLSDDYFPTVLE--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNT 3247

Query: 769  GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
            G I T   L+ E +  Y L V A +     R S  T+ I++   ++  P F +  Y   +
Sbjct: 3248 GVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEI 3307

Query: 829  EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
             E  P GT + ++ A D DLG +  V Y I     K  F ++  TG++ +   LD E   
Sbjct: 3308 SEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK-- 3365

Query: 887  DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
            ++  S+  L + F           TV V V D ND PP+F+  IY   ++     GT +T
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVT 3424

Query: 947  TVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
             V A D+D   +P+ SR  Y +           F +   +G++     L+ E   I+ L 
Sbjct: 3425 FVSAFDSD--SIPSWSRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRETLPIYNLS 3479

Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA--- 1061
            V+A D G P  + SA++ + +    +  P  T  E     V E    GT+V  + +    
Sbjct: 3480 VLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMTLQSTDPD 3536

Query: 1062 -AINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
               NQ    Y ++S     ++   +  GV+     +D E    + L        VV  + 
Sbjct: 3537 LPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL-------SVVTKDS 3589

Query: 1120 RVPSKSNTAKVYIEIQDENNHP 1141
             VP  S+T  V+I + D+N++P
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDNP 3611



 Score =  260 bits (665), Expect = 7e-69
 Identities = 303/1158 (26%), Positives = 498/1158 (43%), Gaps = 135/1158 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
            V + ++D NDN+P F  + Y AT++E     T +         A+D+D+G NG I Y +I
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV-----SASDVDEGNNGLIHYSII 1250

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ-NLNERRTTTTT 250
            + N +   + D+       +G + L  +L+YE    Y ++IQA D     LN    +T T
Sbjct: 1251 KGNEERQFAIDS------TSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLN----STCT 1300

Query: 251  LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
            L +D+LD +D  P F    L           +   +  +R  E ++ +  T      D D
Sbjct: 1301 LNIDILDENDNTPSFPKSTL-----------FVDVLENMRIGELVSSVTAT------DSD 1343

Query: 311  RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
                   D   + YSI   T  +    F + P T  + L + ++ +    + L I A+  
Sbjct: 1344 SG-----DNADLYYSI---TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ 1395

Query: 371  NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
               P  +   + I + D N+  P F        I+E+ P+G         TS + + A D
Sbjct: 1396 GRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIG---------TSVISVTAHD 1446

Query: 431  KDIEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
             D +        +       + FT+ +   T Y      +DRE    +  ++ A D    
Sbjct: 1447 PDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNA--EIDREFANLFELTVKANDQAVP 1504

Query: 490  SEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ-LTAVDADEGSNGE 543
             E        V I V D NDN P F  IS +           SV+  + A D DEG+NGE
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPDEGANGE 1562

Query: 544  ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
            I YEI+ G    FI+++ +G + +A  + +     Y L V A D  P   +  +  T+ +
Sbjct: 1563 IEYEIINGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIIL 1621

Query: 604  EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-------ITYAIENGD 656
            + L       P F Q  Y   + E   +G  +++++A    G         ++   E   
Sbjct: 1622 QGL-----DGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT 1676

Query: 657  PQRVFNLSETTGILTLGKALDRESTDRYILI----ITASDGRPDGTSTATVNIVVTDVND 712
              R+F +   TGI+     LDRE      L+    I  S   P  T  A V I + D+ND
Sbjct: 1677 VGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFP-RTQRAEVEITLQDIND 1735

Query: 713  NAPVFDPYLPRNLSVVEEEAN-AFVGQVKATDPDAGINGQVHYS-LGNFNNLFRI-TSNG 769
            N PVF P    +L+V E   + + + Q+ A D D G N  V Y+ +   ++ FRI   +G
Sbjct: 1736 NPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESG 1794

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
             +    +L+RE R  Y L+V A DG    + S + + I V D++D++P F+   Y+  + 
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851

Query: 830  ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
            E+   G+ +  I A D D G N  ++Y +   +    F L+P TG  +L R LDYE    
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV--- 1908

Query: 888  QEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
             +      V A D  G       T+ V   + D+ND PP+FS   Y   +  +   G+ +
Sbjct: 1909 -QQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTV 1963

Query: 946  TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKL 1004
                  DAD  G+  S++ Y +         S+ +   D   V+  +  L+ E  + + L
Sbjct: 1964 LVFNVTDAD-DGI-NSQLTYSIASGD-----SLGQFTVDKNGVLKVLKALDRESQSFYNL 2016

Query: 1005 VVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEE--YRP--PPVSELATKGTMVG 1056
            VV   D  +   S   S+A V I++L   +  P F   +  Y P   P+  +  K     
Sbjct: 2017 VVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATD 2076

Query: 1057 VISAAAINQSIVYSIVS--GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
              S    N  I Y++++  GN+   F I  I G + + G LD E  ++Y       +L V
Sbjct: 2077 PDSGP--NSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNY-------TLTV 2124

Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
            V  +   PS S++ +V + + D N++ P+F +  Y   ++E+    T +++V A D D G
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184

Query: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1234
                + Y ++        + F +++ TG I  A      +   +   V ATD   +G + 
Sbjct: 2185 TNGQVRYGIV---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD---RGSTP 2238

Query: 1235 KADVLVSVVNQLDMQVIV 1252
            + D     +  LD+   V
Sbjct: 2239 RTDTSTVSIVLLDINDFV 2256



 Score =  250 bits (639), Expect = 7e-66
 Identities = 288/1091 (26%), Positives = 459/1091 (42%), Gaps = 109/1091 (9%)

Query: 130  YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
            Y +V + V+D NDN P F    Y A V E   VG+++         A D D+G N  I Y
Sbjct: 233  YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287

Query: 190  VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
             +Q +   P   D        TG I +R+ L++E + +Y + +QA DR       R    
Sbjct: 288  RLQ-DEGTPFQMDP------ETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL 340

Query: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
               +DV D D                   P+      P       ++       + A+  
Sbjct: 341  IQLLDVNDND-------------------PVVKFRYFPATSRYASVDENAQVGTVVALLT 381

Query: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMH----PRTAELSLLEPVNRDFHQKFDLVI 365
              +   P+    I   IL G  +   R F +     P  + + +   ++R+    ++L +
Sbjct: 382  VTDADSPAANGNISVQILGGNEQ---RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTV 438

Query: 366  KAEQDNGHPLPA-------FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 418
                + G P  A        A L I + D N+  P F+   Y+  + E AP G+ +S   
Sbjct: 439  SVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG-- 496

Query: 419  NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
                   I A D D     +    +   +    F +++            +DRE      
Sbjct: 497  -------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIV 549

Query: 479  FSITAFDGVQESEPVI----VNIQVMDANDNTPTF--PEISYDVYVYTDMRPGDSVIQLT 532
             +I+A D  Q   P +    + + ++D ND  P F  PE  YDV V  +   G  ++ L 
Sbjct: 550  LNISARD--QGVHPKVSYAQLVVTLLDVNDEKPVFSQPE-GYDVSVVENAPTGTELLMLR 606

Query: 533  AVDADEGSNGEITYEILVGAQGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 589
            A D D G NG + +  L  A+ D   F ++  +G ++    ++      Y+L V A D  
Sbjct: 607  ATDGDLGDNGTVRFS-LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665

Query: 590  PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 646
             P +  +S+  + + +L  N+ SP  +P + Y   I E    G+ +  + ATD +     
Sbjct: 666  SPPQ--SSMARINVSLLDINDNSPVFYP-VQYFAHIKENEPGGSYITTVSATDPDLGTNG 722

Query: 647  SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
            ++ Y+I  GD  R F ++  +G+++   ALDRE    Y L I A+D G     + A V I
Sbjct: 723  TVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781

Query: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFR 764
             V D  DN PVF   +  +  V E  A  + VG V A+  D   N     + G+   +F 
Sbjct: 782  TVLDTQDNPPVFS-QVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFA 840

Query: 765  ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
            I    G + TA  ++RE + +Y+L VVA+ G V        + I V D++DNSP F  + 
Sbjct: 841  INQVTGQLTTANVIDREEQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAI 897

Query: 824  YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
             +V V EN  AG +I Q +A D D G N  V Y ++    K+ FA++   G +SLL  LD
Sbjct: 898  ESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD 956

Query: 882  YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 941
              A      S    + A D+          +TV V D+ND  PVF +  Y+  ++     
Sbjct: 957  VHA-----GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPV 1011

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
             +    V A D D        + Y + +        IF      G++  +  L+ E    
Sbjct: 1012 NSRFFKVQASDKDSGA--NGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDR 1065

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA 1060
            + L+VVA D     +S++  V +++    +  P F    Y      E    G+ VG +SA
Sbjct: 1066 YVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKVSA 1124

Query: 1061 A----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEV 1114
                   N  + YS      +  F ++ I+G I      D   R S + R      S  V
Sbjct: 1125 VDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFD---RESLMRRRGTAVFSFTV 1179

Query: 1115 VLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
            +  +  +P    + A V++ ++D N++ P F K FY   +SE A   T VLRV A+D D 
Sbjct: 1180 IATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDE 1239

Query: 1174 GNYSVMAYRLI 1184
            GN  ++ Y +I
Sbjct: 1240 GNNGLIHYSII 1250



 Score =  234 bits (598), Expect = 4e-61
 Identities = 238/874 (27%), Positives = 378/874 (43%), Gaps = 99/874 (11%)

Query: 81   VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
            +  + +MD         STG ++   P     +   +++      G  +  +V I V D 
Sbjct: 2806 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865

Query: 141  NDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
            NDN+P F   SYY    ELT +G+ +   F     ATD D+G NGQ+ Y I+   +    
Sbjct: 2866 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF-----ATDPDEGSNGQVFYFIKSQSEYFRI 2920

Query: 201  NDTFEIPLMLTGNIVLRKRLNYEDKT--------RYFVIIQANDRAQNLNERRTTTTTLT 252
            N T       TG I  ++ L Y++ T        R+  I+ ++DR +       + TT+T
Sbjct: 2921 NAT-------TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK---PSLISETTVT 2970

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ--AIDQD 310
            ++++D +D  P FL                     +  TP   N  + T  I+  AID D
Sbjct: 2971 INIVDSNDNAPQFLK-------------------SKYFTPVTKNVKVGTKLIRVTAID-D 3010

Query: 311  RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
            ++    S+   + Y I   + +++   F +   T  +S+   +  D +Q F + + A+  
Sbjct: 3011 KDFGLNSE---VEYFI---SNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDK 3064

Query: 371  NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
               PL + A +HI + +EN  +P F+       I ES  +G+ +           + A D
Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR---------TVSARD 3115

Query: 431  KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
            +D       +  +   +   +F +  +  T  LTL + +D E  Q +  +I+A DG  V 
Sbjct: 3116 RDAAMNGLIKYSISSGNEEGIFAINSS--TGILTLAKALDYELCQKHEMTISAIDGGWVA 3173

Query: 489  ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
             +    V + V+D NDN+P F    Y   V  +   G +VI L A DAD G+N  I Y +
Sbjct: 3174 RTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTV 3233

Query: 549  LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
                   F+I+  TG+IT    ++    ++Y LTV+A +   P E R S  TV I+ L  
Sbjct: 3234 QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQ-LKG 3290

Query: 609  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSE 665
             N+  PRF   +Y  EISEA   G ++  + A+DR+      + Y I     ++ F +++
Sbjct: 3291 TNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK 3350

Query: 666  TTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLP 722
             TG + +   LDRE  +R  L + A +    R       TVN+ V D ND      P   
Sbjct: 3351 KTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-----PPIFT 3405

Query: 723  RNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYT 773
             N+  V+      +G     V A D D+ I     +S     GN N  F I    G I  
Sbjct: 3406 LNIYSVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSINPQTGQITV 3464

Query: 774  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
              +L+RE    Y L V+A D        + +L + + DI+DN P+ T S   V+  EN  
Sbjct: 3465 TAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKR 3522

Query: 834  AGTTILQIEAKDVDLGAN----VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 889
             GT ++ +++ D DL  N      Y + +     +F+L    G LS  R +D E   D  
Sbjct: 3523 PGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFY 3581

Query: 890  ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
             S+       D          TV + V D ND P
Sbjct: 3582 LSVV----TKDSGVPQMSSTGTVHITVIDQNDNP 3611



 Score =  216 bits (550), Expect = 1e-55
 Identities = 244/842 (28%), Positives = 373/842 (44%), Gaps = 76/842 (9%)

Query: 445  LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 504
            L++  ++F +  +    Y T    +DRE   +   ++        + P  V + V D ND
Sbjct: 74   LSESHALFAINSSTGALYTT--STIDRESLPSDVINLVVLSSAP-TYPTEVRVLVRDLND 130

Query: 505  NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--EITYEILVGAQ-GDFIINKT 561
            N P FP+ S  V    D   G  VI  TA D+D GSNG    +Y I+ G + G F ++ T
Sbjct: 131  NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190

Query: 562  TG--------LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 613
                       +    G++  V   Y L V+  D   P  R      V ++ +   N +P
Sbjct: 191  LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI---NDNP 247

Query: 614  PRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSETTGILTL 672
            P F    Y   + E   VG+ +L + A D  EG +        D    F +   TG++T+
Sbjct: 248  PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITV 307

Query: 673  GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEE 730
             + LD E+  +Y L + A D G P  T  A   I + DVNDN PV    Y P        
Sbjct: 308  REPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASV 367

Query: 731  EANAFVGQVKA----TDPDA-GINGQVHYSL--GNFNNLFRITSN-----GSIYTAVKLN 778
            + NA VG V A    TD D+   NG +   +  GN    F + S+       I  A  L+
Sbjct: 368  DENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALD 427

Query: 779  REVRDYYELVVVATD-------GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 831
            RE    Y L V  +D        AV  R S  +L I V DI+D+ PVF+   Y V + E 
Sbjct: 428  RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487

Query: 832  LPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPD 887
             P G+ +  I A D D  L AN+ Y I S     +F +   +G ++   S  LD E    
Sbjct: 488  APPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL--- 544

Query: 888  QEASITFLVEAFDIYGTMPP-GIATVTVIVKDMNDYPPVFSK-RIYKGMVAPDAVKGTPI 945
              + I   + A D  G  P    A + V + D+ND  PVFS+   Y   V  +A  GT +
Sbjct: 545  -ASQIVLNISARD-QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602

Query: 946  TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
              + A D D        VR+ + + +    +  F ++  SGR+ T  +L+ E    + L+
Sbjct: 603  LMLRATDGDLG--DNGTVRFSLQEAETDRRS--FRLDPVSGRLSTISSLDREEQAFYSLL 658

Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA--- 1061
            V+A D G P  SS A + + +L   +  P F   +Y    + E    G+ +  +SA    
Sbjct: 659  VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPD 717

Query: 1062 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
               N ++ YSI +G +   F +N  +GVI     LD E +T+Y L++ A        NL+
Sbjct: 718  LGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD----GGNLQ 772

Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
             P   N A V I + D  ++PPVF +  Y   V E+  +   V  V A+  D    S ++
Sbjct: 773  SP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNIS 827

Query: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
            Y LI    ++G   F +   TG + TA +     +S+++ +V+A+   G  ++G   V +
Sbjct: 828  Y-LITTGDQKGM--FAINQVTGQLTTANVIDREEQSFYQLKVVAS---GGTVTGDTMVNI 881

Query: 1241 SV 1242
            +V
Sbjct: 882  TV 883



 Score =  186 bits (471), Expect = 2e-46
 Identities = 205/752 (27%), Positives = 325/752 (43%), Gaps = 78/752 (10%)

Query: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP--PAERRNSICTVYIEVLPPNNQSP 613
            F IN +TG +     ++     +  + +    +AP  P E R     V +  L   N + 
Sbjct: 81   FAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR-----VLVRDL---NDNA 132

Query: 614  PRFPQLMYSLEISEAMRVGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTG 668
            P FP     +   E    G  ++   ATD +      D  +Y I  G+    F L  T  
Sbjct: 133  PVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN 192

Query: 669  ILTLGK--------ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 719
                G          LDRE T +Y L++   D G P       VN+ V D+NDN PVF  
Sbjct: 193  PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS 252

Query: 720  YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVK 776
                  + V E+A   + V QV A D D G N  + Y L +    F++    G I     
Sbjct: 253  --SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310

Query: 777  LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-----FTNSTYTVLVEEN 831
            L+ E R  Y L V A D  V          I++LD++DN PV     F  ++    V+EN
Sbjct: 311  LDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDEN 370

Query: 832  LPAGTTILQIEAKDVDLGA---NVSYRIRSP-EVKHFFALHPFTGELSLLR---SLDYEA 884
               GT +  +   D D  A   N+S +I    E +HF         LSL++   +LD E 
Sbjct: 371  AQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRER 430

Query: 885  FPDQEASITFLVEAFDIYGTMPPG--------IATVTVIVKDMNDYPPVFSKRIYKGMVA 936
             P    S    V   D YG  PPG        +A++ + V D+ND+PPVFS+++Y+  ++
Sbjct: 431  IP----SYNLTVSVSDNYGA-PPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLS 485

Query: 937  PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--L 994
             +A  G+ ++ + A D D  GL A+ +RY +           F + E SG V T  +  L
Sbjct: 486  EEAPPGSYVSGISATDGDS-GLNAN-LRYSIVSGN---GLGWFHISEHSGLVTTGSSGGL 540

Query: 995  NEEPTTIFKLVVVAFDDG-EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
            + E  +   L + A D G  P +S +  V  L+    E P F+Q E     V E A  GT
Sbjct: 541  DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600

Query: 1054 MVGVISAA----AINQSIVYSIVSGN-EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
             + ++ A       N ++ +S+     +  +F ++ ++G +     LD E +  Y     
Sbjct: 601  ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFY----- 655

Query: 1109 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1168
              SL V+  +L  P +S+ A++ + + D N++ PVF    Y   + E+    + +  V A
Sbjct: 656  --SLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSA 713

Query: 1169 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1228
            TD D G    + Y +        +  F V   +G+I T M      ++ ++ Q++ATD  
Sbjct: 714  TDPDLGTNGTVKYSISAGD----RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769

Query: 1229 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
                  +A V ++V++  D   + S V  + V
Sbjct: 770  NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801



 Score =  172 bits (436), Expect = 2e-42
 Identities = 186/645 (28%), Positives = 296/645 (45%), Gaps = 61/645 (9%)

Query: 638  LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 697
            L  T +     TY +   +   +F ++ +TG L     +DRES    ++ +      P  
Sbjct: 60   LVGTIQTRPGFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP-- 115

Query: 698  TSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQVH 753
            T    V ++V D+NDNAPVF DP    ++ V  +E ++   QV    ATD D G NG  H
Sbjct: 116  TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVDH 171

Query: 754  YSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPRH 800
             S     GN    FR  IT N S       + +   L+REV   Y+L+V   D     R 
Sbjct: 172  RSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRR 231

Query: 801  STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 860
              L + + V DI+DN PVF +S Y   V E+   G+++LQ+ A D D G N   R R  +
Sbjct: 232  GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD 291

Query: 861  VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
                F + P TG +++   LD+EA   ++ S+T  V+A D       G A   + + D+N
Sbjct: 292  EGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDVN 347

Query: 921  DYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFPY 974
            D  PV   R +        V  +A  GT +  +   DAD P    +  V+    + Q  +
Sbjct: 348  DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF 407

Query: 975  PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHPG 1030
                 +V   S  +     L+ E    + L V   D+ G P    + + ++V  LV+   
Sbjct: 408  EVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVN 466

Query: 1031 EI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGI 1082
            +I    P F+Q+ YR   +SE A  G+ V  ISA    + +N ++ YSIVSGN    F I
Sbjct: 467  DINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525

Query: 1083 NNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            +  +G++    +G LD E  +  VL + A        +  V  K + A++ + + D N+ 
Sbjct: 526  SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVNDE 578

Query: 1141 PPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
             PVF Q + Y   V E+A   T +L ++ATD D G+   +  R  +   +  +  F ++ 
Sbjct: 579  KPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLDP 636

Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1244
             +G + T        ++++   V+ATD      S  A + VS+++
Sbjct: 637  VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681



 Score =  169 bits (429), Expect = 2e-41
 Identities = 196/756 (25%), Positives = 323/756 (42%), Gaps = 74/756 (9%)

Query: 109  MNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
            +N HS +V       K   I    V I + D NDN+P F    Y+  V +   VGT +  
Sbjct: 2946 INRHSFIV-TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004

Query: 169  GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDK 225
              + D    D D G N ++EY I        SND       L   TG I +   L  +  
Sbjct: 3005 VTAID----DKDFGLNSEVEYFI--------SNDNHLGKFKLDNDTGWISVASSLISDLN 3052

Query: 226  TRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 285
              +F+ + A D+    N   ++  T+ + V + +   P F    +             A 
Sbjct: 3053 QNFFITVTAKDKG---NPPLSSQATVHITVTEENYHTPEFSQSHM------------SAT 3097

Query: 286  IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
            IPE      +  I+ T  + A D+D  +        I YSI  G  E     F ++  T 
Sbjct: 3098 IPE---SHSIGSIVRT--VSARDRDAAMNGL-----IKYSISSGNEEG---IFAINSSTG 3144

Query: 346  ELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
             L+L + ++ +  QK ++ I A          +  + + ++D N+ SP F    Y   +L
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204

Query: 406  ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
            E+AP G T+         + + A D D   T     +   +  + +F +     T  +T 
Sbjct: 3205 ENAPSGTTV---------IHLNATDAD-SGTNAVIAYTVQSSDSDLFVIDPN--TGVITT 3252

Query: 466  LQPVDREEQQTYTFSITAFDGVQESEP--VIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
               +D E +Q+Y  ++ AF+   E       VNIQ+   N+  P F    Y   +     
Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312

Query: 524  PGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALT 582
             G  V ++ A D D G++GE+ Y I   + +  F INK TG I ++  ++       +L 
Sbjct: 3313 KGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372

Query: 583  VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
            V A +            TV + VL  N+  PP F   +YS++ISE + +G  +  + A D
Sbjct: 3373 VLAKNFGSIRGADIDEVTVNVTVLDAND--PPIFTLNIYSVQISEGVPIGTHVTFVSAFD 3430

Query: 643  REG----DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 697
             +        +Y I +G+    F+++  TG +T+   LDRE+   Y L + A D G P  
Sbjct: 3431 SDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA 3490

Query: 698  TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN-GQVHY-- 754
            T +A++ + + D+NDN P+    +     +  +     V  +++TDPD   N G   Y  
Sbjct: 3491 TGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYL 3548

Query: 755  -SLGNFNNLFRITSNGSIYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 812
             S G   + F +++ G + T  +++RE + D+Y L VV  D  V    ST T+ I V+D 
Sbjct: 3549 LSTGPATSYFSLSTAGVLSTTREIDREQIADFY-LSVVTKDSGVPQMSSTGTVHITVIDQ 3607

Query: 813  DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
            +DN          V    NL  G  +  ++ +D D+
Sbjct: 3608 NDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643



 Score =  153 bits (387), Expect = 1e-36
 Identities = 184/709 (25%), Positives = 296/709 (41%), Gaps = 90/709 (12%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V I V + N ++P F      AT+ E   +G+ + T       A D D   NG I+Y I 
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-----SARDRDAAMNGLIKYSIS 3129

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
               ++      F I    TG + L K L+YE   ++ + I A D        RT   ++T
Sbjct: 3130 SGNEE----GIFAINSS-TGILTLAKALDYELCQKHEMTISAIDGGW---VARTGYCSVT 3181

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            V+V+D +D  P+FL     P   +  P             +     ++   +Q+ D D  
Sbjct: 3182 VNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-- 3239

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
                                     F + P T  ++    ++ +  Q + L +KA     
Sbjct: 3240 ------------------------LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPD 3275

Query: 373  HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
                +FA ++I++   N   P F    Y   I E+AP G  + +         + A D+D
Sbjct: 3276 EERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE---------VFASDRD 3326

Query: 433  IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQ-- 488
            +    +    +F N     F + +     Y++ +  +DRE+++  +  + A  F  ++  
Sbjct: 3327 LGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLAKNFGSIRGA 3384

Query: 489  ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE-GSNGEITYE 547
            + + V VN+ V+DAND  P F    Y V +   +  G  V  ++A D+D   S    +Y 
Sbjct: 3385 DIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYF 3443

Query: 548  ILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
            I  G + G F IN  TG IT+   ++      Y L+V A D+  P+   ++   V +E +
Sbjct: 3444 IGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDI 3503

Query: 607  PPNNQSPPRFPQLMYSL-EISEAMRVGAVLLNLQATD-----REGDSITYAIENGDPQRV 660
              N       P L  S  E+ E  R G +++ LQ+TD      +G    Y +  G     
Sbjct: 3504 NDNG------PMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSY 3557

Query: 661  FNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDP 719
            F+LS T G+L+  + +DRE   D Y+ ++T   G P  +ST TV+I V D NDN     P
Sbjct: 3558 FSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-----P 3611

Query: 720  YLPRNLSV-VEEEANAF----VGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYT 773
               R + + V    N F    +G VK  DPD  +    H SL     +LF I   G    
Sbjct: 3612 SQSRTVEIFVNYYGNLFPGGILGSVKPQDPD--VLDSFHCSLTSGVTSLFSIP--GGTCD 3667

Query: 774  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
                 R     ++L V++ DG     HST+T  I+V     ++    NS
Sbjct: 3668 LNSQPRSTDGTFDLTVLSNDGV----HSTVTSNIRVFFAGFSNATVDNS 3712


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  324 bits (830), Expect = 5e-88
 Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)

Query: 99   TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
            +G ++   P   +   V +++  NK+    +  +V I + D ND++P F+   Y A VNE
Sbjct: 426  SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483

Query: 159  LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
              PVGT++ T       A+D D G NG I Y I      P   + F      TG I   +
Sbjct: 484  SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532

Query: 219  RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
             L++E     Y  I++A+D       R  +   +T+ + + +D  P+F  + C  V    
Sbjct: 533  ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586

Query: 276  DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
                ++Y   +    T            + AID D       +   + Y I+ G      
Sbjct: 587  ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622

Query: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
             FF+++P +  L L + +     +  +  ++    +G  L     ++I +L         
Sbjct: 623  -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681

Query: 388  ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
                                       E+    ++++     Y  +S P    + + L +
Sbjct: 682  SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741

Query: 421  -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
              + L+I A D D          +   +  S F +     T  L +L P+DRE    Y  
Sbjct: 742  GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799

Query: 480  SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
            +IT +D    Q+S   ++ I V DANDN+P F + SY V +      G  +IQ+ A D D
Sbjct: 800  NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859

Query: 538  EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
             GSNGE+TY +L   Q  F IN +TG++ +A  ++      Y+L ++A D A   ++  S
Sbjct: 860  LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918

Query: 598  ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
            + T+ + +   N+ SP   P   YS+++ E + VG V+  L+  D +   G  + Y++ N
Sbjct: 919  VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977

Query: 655  GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
             D    F + + +G + L K LD E    Y L + A D GRP   S+ + V + V DVN+
Sbjct: 978  -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036

Query: 713  NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
            N  +  PY P    V   + N+ +G    QV A D D+G +G++ YS+ + + L R +  
Sbjct: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094

Query: 767  -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
              +G I  A  L+RE    Y L V ATD  V P +ST+ + I+V D++DN+P+ +   Y 
Sbjct: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154

Query: 826  VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
             +V EN P   +++QI+A+D D  +N  ++YRI S   ++FFA++  TG ++   R LD 
Sbjct: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214

Query: 883  EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
            E    Q+A     V   D  G   P  +T+ V+V+  D ND  P F +++Y+ +  P+  
Sbjct: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267

Query: 939  -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
               +G PI   +A D D    P + + Y + D         F ++  +G V +R      
Sbjct: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322

Query: 998  PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
               I  L + A D+G P  SS+A + I  +    P  IP    E +    V E      +
Sbjct: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
            VGV+S    N  + + IV GN +  F      G I +  PLD E R+ Y + V+  D   
Sbjct: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440

Query: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
            V +            +V+I++ D N++ P F +  Y   +SED    T +L+++ATD+D 
Sbjct: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489

Query: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
             +         I  I   K  F ++  TG++ TA    +  +      ++  D       
Sbjct: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547

Query: 1234 GKADVLVSVVNQLDMQVIVSN 1254
              A V+V+V +  D     +N
Sbjct: 1548 NLARVIVNVEDANDHSPYFTN 1568



 Score =  311 bits (796), Expect = 4e-84
 Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            +V I V   N  SP F   +Y A V E    GT +         ATD D G  GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
                 +  + D F I     G ++  +RL+ E+       + ++A D        RTT  
Sbjct: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584

Query: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
            T+ V V+D +D  P F+             + Y+A++       ++    +   +QAID 
Sbjct: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627

Query: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
            D           I YS+             + P    +      N+  +      +KA  
Sbjct: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681

Query: 370  DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
            D G P+  +   ++I +L      P FT   Y   I E   +G+T+ D+L +     +  
Sbjct: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740

Query: 429  LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
               + E    PE     N+   +F + Q   T  + L + +DRE    + F + A    D
Sbjct: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790

Query: 486  GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
             V     V V+I+V+D NDN P F   SYD  +   M  G  + Q+ A+D D G+NG++T
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850

Query: 546  YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            Y +   +Q +     F I+  TG I+    ++     T+  +V A+D    A   +S   
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
            V + V   N+ +P  F Q +Y   + E+   G V+  L   DR+   +    +Y I  G+
Sbjct: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968

Query: 657  PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
            P+  F L   ++   + + + LDRE  D Y L ITA+DG     + A V + V+DVNDN+
Sbjct: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026

Query: 715  PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
            PV D      L   +  +N  + +V A D D G NG + YSL    N   F    +G + 
Sbjct: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086

Query: 773  TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
            T   L+RE    Y L+  ATDG      S + L ++  D++DN PVF++  Y   V EN 
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144

Query: 833  PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
                 + +++A D D+G N  V Y + +      F++   +G + L + LD E    Q++
Sbjct: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199

Query: 891  SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
            S    V A D   G     + TVT+ V D+ND PPVF +R Y   V  D   GT +  V+
Sbjct: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259

Query: 950  AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
            A   D           R  + Q       F++   +G +     L+ E    F LVV A 
Sbjct: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314

Query: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
            D G P +S+ ATV I +    + P +F+Q+ Y    +SE A  G  V ++ A  +    N
Sbjct: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373

Query: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
              I +SIV+G+ ++ F ++ + G++ V   LD E  + Y L VQA        +  +P+ 
Sbjct: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426

Query: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
            S+TA V I+I D N++ PVF    Y   + E+  + TS+L++  TD+D+ +        I
Sbjct: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486

Query: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
            +   +E  E FV++ + G++++A++F +     +   V A D
Sbjct: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525



 Score =  310 bits (795), Expect = 6e-84
 Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            I V D NDNSP F  +SY   + E + +GT I         A D D G NG++ Y +  +
Sbjct: 819  INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                  N +       TG + +  +L+ E K  Y + I+A D+A++  ++  +  TL V 
Sbjct: 874  TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            + D +D  P F+P                     ++  E+L    V   ++  D D  + 
Sbjct: 926  LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
                   + YS++     DY   F +   +  + L + ++ +  Q ++L ++A+ D G P
Sbjct: 969  GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018

Query: 375  --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
              L + + + +E++D  EN  +PYF   +  G + E++ +G         TS L++ A D
Sbjct: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069

Query: 431  KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
            +D    +D E+   + D + +   +    +  +T    +DRE   +Y  ++ A D   V 
Sbjct: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127

Query: 489  ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
                + V I+V D NDN P   E  Y   V  +     SVIQ+ A D D  SN ++TY I
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187

Query: 549  LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
              G  Q  F IN  TGLIT     ++      + L V   D  P  ++  S   V ++VL
Sbjct: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245

Query: 607  PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
              N+  P +FP+ +Y +++ E  R   G  +    A DR+      I+Y+I +G+    F
Sbjct: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304

Query: 662  NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
             +   TG+++  K     S D  IL I A D GRP  +STA ++I        +P+   F
Sbjct: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362

Query: 718  D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
            D P+   N +V+E +    +  V +  P    N  + + +  GNF++ F      G+I  
Sbjct: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417

Query: 774  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
            A  L+ E R  Y + V  TDG      +   + IKVLD +DN P F+   Y V + E++ 
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474

Query: 834  AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
              T ILQIEA D D    +SY + S         F + P TG L     LD+EA      
Sbjct: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534

Query: 891  SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
            +I    + F     +    A V V V+D ND+ P F+  +Y+  V   A  G+ +  V A
Sbjct: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590

Query: 951  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
             D D  G  A  +      ++     ++F++E     V+  + + +EP  TT+  F L +
Sbjct: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641

Query: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
               D G P MS++A V+I V +     P+F  ++Y+   V+E    GT V +ISA +   
Sbjct: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699

Query: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
            +++Y +  G+    F IN  +GVI     LDYE  +SY L +QA ++  + +N       
Sbjct: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752

Query: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
              A V I+I DEN++ PVF    Y G +SE A        +  S L ++ATD D+   ++
Sbjct: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810

Query: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
            + Y+++       K+ F V++ TG I+T     +   ++F F V   D     L+ ++ V
Sbjct: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867

Query: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
                  +++++V   N  P +  + + +   +L  YV  ++
Sbjct: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902



 Score =  271 bits (694), Expect = 3e-72
 Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            +V I V D ND  P F   +Y  T+ E TP+ T++         ATD D G NG+  Y  
Sbjct: 143  KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
            +   D  + + T       +G I L  RLNY++K RY + I A DR   L  N   ++T 
Sbjct: 198  KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250

Query: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
             L V +   ++  P       VP + +  P TY                +VT  +  +D 
Sbjct: 251  KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292

Query: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
              N +  S       SI+ G P D            E  + E    D   F   ++L ++
Sbjct: 293  GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346

Query: 367  AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
            A+ D G P    A   ++I     +     F    Y   I E +P G             
Sbjct: 347  AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393

Query: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
             +VA+ K   +  D E  L   +    F +  ++G+   +   +P++  +++ Y   +T 
Sbjct: 394  -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449

Query: 484  FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
             +G  +++   V I + DAND+TP F +  YD YV   +  G SV+ ++A D D+G NG 
Sbjct: 450  KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506

Query: 544  ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
            ITY I       F+IN+ TG+I+    ++       Y   V+A+D   P  R  S   V 
Sbjct: 507  ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565

Query: 603  IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
            I +   N+ S P F ++     IS    VG  +  + A D  E + + Y I +G+    F
Sbjct: 566  IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624

Query: 662  NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
             L+  +G+L L K+L         + L ITA+DG  +     ++NI V            
Sbjct: 625  YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683

Query: 709  ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
                                              +N   P FD   P +++V E+    A
Sbjct: 684  RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743

Query: 735  FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
             + ++KA D D+G NG+V +++  GN ++ F I    G +   + ++RE  D Y L +  
Sbjct: 744  NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803

Query: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
             D     + S   L I V D +DNSPVF   +Y+V + E+   GT I+Q+EA+D DLG+N
Sbjct: 804  YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863

Query: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
              V+Y + +   +  FA++  TG + +   LD E+    +A+ +  +EA D    G    
Sbjct: 864  GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917

Query: 908  GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
             + T+ V + D+ND  P F    Y   V  D   GT I   + E  DP      +VRY  
Sbjct: 918  SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975

Query: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
            V+D         FE+++ SG +     L+ E    + L V A D G PV +SS + V++ 
Sbjct: 976  VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030

Query: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
            V      LH    P F         V E +  GT V  ++A    +  +  I YSI  G+
Sbjct: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086

Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
                F I++ +GVI     LD ET  SY L V A    VV          +T +VYIE++
Sbjct: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139

Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
            D N++ P+  +  Y   V E++    SV++++A D D+ +   + YR+        +  F
Sbjct: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196

Query: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
             +   TGLI T    L    +  +F  +V  TD    G S K   +  VV  LD
Sbjct: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246



 Score =  271 bits (694), Expect = 3e-72
 Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V ++V D NDN P F   +Y  T++E + +GT +    S      D D   N  + Y  Q
Sbjct: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
               D   S D F I    +G I+  + L++E      + +++ D         ++   + 
Sbjct: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            + + D +D  P+F              L Y++ + EL              +QA D D  
Sbjct: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
                SD   + YSIL G        F M  ++  ++L     +     + L +       
Sbjct: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475

Query: 373  HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
                + A +HI +L  N  SP F+  +Y   + E+   G         T  + + A D D
Sbjct: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524

Query: 433  IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
               T     +  +ND+    F +   G    +   + +DRE   +   +  + A DG   
Sbjct: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580

Query: 490  SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
            +    V + V+D NDN P F  + Y   V  D+  G  V Q+ A+D D+G+N  ITY + 
Sbjct: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640

Query: 550  VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
              A     D + I+   G +        +     +  V+A D   P   ++S+  VYI V
Sbjct: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
            LPP     P F Q  YS  I+E   +G+ +  L+    +  ++ ++  NG+ P+     +
Sbjct: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
            F + + TG + L K LDRE++  +   + A+    + D   T  V+I V D+NDN PVF+
Sbjct: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815

Query: 719  PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
                  + +        + QV+A D D G NGQV YSL + +        F I SN G I
Sbjct: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875

Query: 772  YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
             T   L+ E    +   VVA+D G      ST  ++++V DI+DN+PVF    Y   V+E
Sbjct: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935

Query: 831  NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
            + P G  +  +   D    D+   VSY I     +  FAL     E  + + R LD E  
Sbjct: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993

Query: 886  PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
               E  I FL + A D ++ T     A V V V D+ND  PV  +  Y  ++  D     
Sbjct: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046

Query: 944  PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
             I  V A+DAD        +RY +    +    S F ++ +SG + T   L+ E   ++ 
Sbjct: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100

Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
            L+  A D G     S+  + IL       P F+ + Y        ATK  +  V +    
Sbjct: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159

Query: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
              IN+ +VYS+ + +    F I++ +G+I +  PLD E ++SY + V+A           
Sbjct: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212

Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
              S S+   V I + D N++PPVF+++ Y+  V ED    T VL V AT KD G  + + 
Sbjct: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272

Query: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
            Y LI    ++GK  F +   TG I  + +        F   V A D     LS  A V +
Sbjct: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329

Query: 1241 SVVNQLD 1247
            ++ +  D
Sbjct: 3330 NLTDVND 3336



 Score =  261 bits (668), Expect = 3e-69
 Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)

Query: 81   VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
            + Y ++ D  K    ++S G+V     LDR+ P+    + + V+ ++   G   +  VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588

Query: 136  VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
            +V D NDN+P F    Y A+V      G  +         A D DDG N +I Y + Y+ 
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642

Query: 196  DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
               +  D  EI                 D    +++ +      N N+ + T  +  V  
Sbjct: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680

Query: 256  LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
            +DG       L P+++  VL P T           +P     +    I     I +    
Sbjct: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729

Query: 311  RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
              I P  +   + +S + G  PE+     F +   T  + L + ++R+    FH K    
Sbjct: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786

Query: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
            I  ++ +   +     + I++LD N+  P F   SY   I+E  PVG  ++        +
Sbjct: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836

Query: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
            R + +D          LH        +        T +++ L+ +D E   T+TFS+ A 
Sbjct: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896

Query: 485  D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
            D       S   +V+++V D NDN P F +  Y   V     PG+ V  L+  D D    
Sbjct: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956

Query: 541  NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
            N +++Y I  G  +G F +   ++   + +   ++      Y L + A D     +    
Sbjct: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012

Query: 598  ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
               V + V   N+ SP    Q+ Y+  + E +    ++L + A D +  S   I Y++  
Sbjct: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069

Query: 655  GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
            G     F L   +G L     LDRE    Y L+  A+DG       + +++++ DVNDN 
Sbjct: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128

Query: 715  PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
            PVF  D Y   N  V E  A  A + +V+A DPD GIN +V YSL  +   +F I +S+G
Sbjct: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
             I     L+RE +  Y + V ATD +     S+L T+ I VLDI+DN PVF    Y V V
Sbjct: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245

Query: 829  EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
             E+   GT +L + A   D+G N  ++Y IRS   +  F ++P TG +S+   LDYE   
Sbjct: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304

Query: 887  DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
                    +VEA D        +ATV + + D+ND PP FS+ +Y  +++ DA+ G  + 
Sbjct: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361

Query: 947  TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
             + AED D    P  ++ + + +       + F V+   G V  +  L+ E  + + L+V
Sbjct: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416

Query: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
             A D G P MSS+ATV I +    +  P FT   Y    + E    GT +  +     + 
Sbjct: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475

Query: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
                    +SI+SGNEE+ F + +  G++       +     YVL VQA        +  
Sbjct: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527

Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
             P + +   + + + +E+ H P            ED      + ++ ATD+D   Y V+ 
Sbjct: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585

Query: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
            + L      E K  F V ++ G I
Sbjct: 3586 FAL----KSEQKSLFKVNSHDGKI 3605



 Score =  259 bits (662), Expect = 2e-68
 Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)

Query: 74   ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
            +L     V Y VL D  +Q    +STG V     LDR+   N +S+ ++ +    + G  
Sbjct: 859  DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915

Query: 129  IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
            ++  V  ++ + D ND SP F   SY   V E  PVGT I    + D      D G  GQ
Sbjct: 916  LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970

Query: 187  IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
            + Y +  +      N  FEI    +G I L K L+YE +  Y + ++A D+ + ++   +
Sbjct: 971  VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022

Query: 247  TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
            + + + V+V+D ++    P F    +V + ++                   N  I T  +
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063

Query: 305  QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
            Q   +D +    S R G I YSI  G+       F +   +  ++  + ++R+    + L
Sbjct: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116

Query: 364  VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
             + A      PL +   ++IE+ D N+ +P  + P Y   ++E++P   ++         
Sbjct: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167

Query: 424  LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
            ++I A D D    +     +   +  + F +  +TG+    T  + +DRE+Q  +   +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225

Query: 483  AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
              DG    +   + V +QV+D NDN P FPE  Y + +    R   G+ + +  A D DE
Sbjct: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285

Query: 539  GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
            G N EI+Y I+ G   G F I+  TG+++     +   G    LT++A DN  P  +++S
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341

Query: 598  ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
               ++IE +  PP +  P  F +  Y+  + E+ RV  ++  + +       + + I  G
Sbjct: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
            +    F+  +  G + + K LD E    Y + +  +DG     +   V I V D NDN P
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458

Query: 716  VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
             F    P     + E+   +  + Q++ATD D    ++  VH S+ + +   FRI  S G
Sbjct: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
             +YTA +L+ E +D + L ++  D     R +   + + V D +D+SP FTN  Y   V 
Sbjct: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576

Query: 830  ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
            E+   G+ +LQ+ A D D G N    Y I +    + F + P  G +++ +       PD
Sbjct: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630

Query: 888  QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
                  F++         PP  AT  V + V   ++  P F  + Y+  V  +   GT +
Sbjct: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690

Query: 946  TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
              + A       +  S + Y V D        IF +   SG + T+  L+ E T+ ++L+
Sbjct: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740

Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
            + A +     M+S+ATV I ++   +  P F   +Y    +SE A   ++V  +  + + 
Sbjct: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797

Query: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
                      N  +VY IV    +  F +++ TG I     LD+ET   +   V   DS 
Sbjct: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857

Query: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
               L      +  +  +V IE+ D N++PPVF +  +   +     +   VL+V ATD D
Sbjct: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911

Query: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
            +     + Y L+     EG  + F++++ +G++   +  +N+ + ++   V  +D
Sbjct: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959



 Score =  256 bits (655), Expect = 1e-67
 Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            VRI V   +++ P F H+ Y A VNE   +GT++    S  + +T I +  +G I  +  
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
             NP               +G I  +K L+YE  + Y +IIQA + A        +  T+ 
Sbjct: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            + ++D +D  P+FL       ++    L+  A I  +    + +P++    I+A D D N
Sbjct: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
                     ++Y I+  T +   +FF +   T  +  +  ++ +    F   +       
Sbjct: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858

Query: 373  HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
              L A + +  +IE+ D N+  P FT         +P+Y G                   
Sbjct: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918

Query: 403  -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
             Y L    +   + DS +    ++   L KD                      +++  D 
Sbjct: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978

Query: 440  ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
             LH   + Y++  +   T IT+                                    T 
Sbjct: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038

Query: 466  LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
              P DREEQ+ Y   + A    D ++ +  V+V + + D NDN+P F  + Y   V  D 
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097

Query: 523  RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
             PG  + Q+TA+D D+G NGE+TY +L    G F IN  +G + +       +    Y +
Sbjct: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156

Query: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
            T+ A D   P     S+ T     +   N++ P F +  Y+  ++E +R+   +L++ AT
Sbjct: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211

Query: 642  DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
              EG  I Y I +GDP + FN+   TG+L +   LD E T  Y L I ASD      +  
Sbjct: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271

Query: 702  TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
            TV+++V DVNDN P+FD   P   + + E +     V QV + D D+  N  VHY +   
Sbjct: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329

Query: 757  -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
              N  + F I +S+G I TA  L+ E+  +  L V + D       S + + I + D++D
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389

Query: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
            N PVF    Y   V E  P G  +  ++A D D      + Y I S   +  F +   +G
Sbjct: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449

Query: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
             ++L         P    +++     F          A V + V   N Y P FS+  Y 
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502

Query: 933  GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
              V  +   GT +  V A D DP      ++ Y + +    +    F + + +G+VIT  
Sbjct: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556

Query: 993  NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
             L+ E        + V A D G    ++  TV+++V+   +  P+F   EYR    +++ 
Sbjct: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614

Query: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
             +G +V  + A       N  I YS+    S +  D   I+   G +   G  +    T 
Sbjct: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673

Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
                V+A        +  +P K +   VYI +       P F +  Y   ++ED  + ++
Sbjct: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726

Query: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
            V  ++        +S      +     E  +G  FV+E  TG IK            F F
Sbjct: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781

Query: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
            +V AT         K D++ +V   +D++V+  N    + E      T   D  + E +P
Sbjct: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828



 Score =  253 bits (647), Expect = 8e-67
 Identities = 284/1096 (25%), Positives = 477/1096 (43%), Gaps = 112/1096 (10%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            +V I V D NDN P F   +Y  T++E     T I         ATD D+    ++ Y +
Sbjct: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
             ++  D  S   F I    TG +   +RL++E + ++ + I   D  Q    RR     +
Sbjct: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             V+V D +D  P F             PL Y+A++ E      L   ++   + A+D+D+
Sbjct: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                  +   ++Y+I  G   +    F + P    +++ +  +     +F L IK     
Sbjct: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647

Query: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
              P+ A A + I +   +N  P F    YQ  + E+  +G         TS + I A+ +
Sbjct: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698

Query: 432  D--IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
               I + KD        D   +FT+     +  +T  + +D E   +Y   I A +    
Sbjct: 1699 STLIYEVKD-------GDINGIFTINP--YSGVITTQKALDYERTSSYQLIIQATNMAGM 1749

Query: 490  SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGSN 541
            +    VNIQ++D NDN P F    Y   + ++  P +S+++        + A DAD   N
Sbjct: 1750 ASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNRN 1808

Query: 542  GEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
              + Y+I+   A+  F ++ +TG I     ++      +   V   D+  P     S   
Sbjct: 1809 ALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVE 1868

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDP 657
            V IEV   N+ +PP F Q ++   +     VG  +L + ATD + +    +TY++  G  
Sbjct: 1869 VNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927

Query: 658  QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
               F +   +G+LT+    +  S D Y+LI+  SDG+    ST+ V I+V +  D+   F
Sbjct: 1928 DH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHF 1982

Query: 718  DPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--TA 774
                    S    E N  + +V   +     +N  + YS+ N  N F+I S   +   T 
Sbjct: 1983 TQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG 2039

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
            V  +RE ++ YELVV A+    H R + + + + + DI+DNSPVF    Y   V+ +   
Sbjct: 2040 VPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEP 2099

Query: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
            GT I Q+ A D D G N        +    F ++P +G + L      EAF    ++I +
Sbjct: 2100 GTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIEY 2154

Query: 895  LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
             V      G  P    +V + +  +N   PVF K  Y   V  D    TPI ++ A   +
Sbjct: 2155 GVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE 2214

Query: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
              G     + Y + D     P   F ++ D+G +     L+ E T+ +KL + A  D   
Sbjct: 2215 GQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDALT 2265

Query: 1015 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVYS 1070
               +  TV +LV    + P    +      +SE +  GT    +V + + +  N+ + Y 
Sbjct: 2266 GARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQ 2325

Query: 1071 IVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
            IV    N  D F I++ +G+I     LD+E        VQ  +L+V   +   PS S+  
Sbjct: 2326 IVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSEV 2378

Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
             V+I I D N++PPVF +  Y   VSE A     V  V+A+D D+ ++  + Y ++    
Sbjct: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL---S 2435

Query: 1189 KEGKEGFVVETYTGLI 1204
               +  F++++ +G+I
Sbjct: 2436 GNDRTSFLMDSKSGVI 2451



 Score =  238 bits (607), Expect = 4e-62
 Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)

Query: 156  VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
            V E  PVG  I         A D D G NG++ + I     D  ++  F I  M TG + 
Sbjct: 735  VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784

Query: 216  LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
            +   ++ E    Y + I   D     N ++++   LT++V D +D  P+F+         
Sbjct: 785  VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834

Query: 276  DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
                 +Y   I E       +  I T  IQ   +D+++    +   + YS+L  T +   
Sbjct: 835  -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876

Query: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
              F ++  T  + + + ++R+    + L I+A  + ++G  L +   L + + D N+ SP
Sbjct: 877  --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934

Query: 394  YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
             F   SY   +LE  PVG  I+                   +T DP+L L        +N
Sbjct: 935  AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977

Query: 447  DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
            DY   F + +   +  + L + +D E+QQ Y  ++ A D    V  S    V ++V+D N
Sbjct: 978  DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035

Query: 504  DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
            +N  TP FP+ +    V  + R G SV+Q+TA D D G +GEI Y I  G+  G F I+ 
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095

Query: 561  TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
             +G+IT A  ++     +Y LTV A D         S   VYIEV   N+ +P     + 
Sbjct: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153

Query: 621  YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
            Y + +  + +  +V + +QA D +  S   +TY I +G+PQ  F ++  TG++ T  + L
Sbjct: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212

Query: 677  DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
            DRE    + L +T +DG P    ST  V + V D NDN P F P     + + E +    
Sbjct: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271

Query: 736  ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
               + +  A D D G N ++ YS+  GN +  F I     + ++ K       Y  L + 
Sbjct: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330

Query: 791  ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
            A D     + ST  L I+ +     SP+       F N  +TV+  + +     ++ ++ 
Sbjct: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388

Query: 844  KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
             +  L     + I        F      G + + + LD E    Q +     VE  D  G
Sbjct: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438

Query: 904  TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
            T    +A   V +K  D ND  P FS+  Y   ++ D +  T I  + A D D     + 
Sbjct: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495

Query: 962  RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
             V   +D +        F ++  +G + T   L+ E      L ++  D   P   + A 
Sbjct: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551

Query: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
            V + V    +  P FT   Y    V E A  G+ V  ++A       N  ++Y+I +GN 
Sbjct: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610

Query: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
             + F I  + G+I +    D  T   +VL ++       + +   P  S TA V I +  
Sbjct: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663

Query: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
             +N  P F  K Y   V+E+  + TSV+ + A  + T          +I  +K+G     
Sbjct: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713

Query: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
            F +  Y+G+I T       R S ++  + AT+    G++  A V + +V++ D
Sbjct: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764



 Score =  186 bits (473), Expect = 1e-46
 Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)

Query: 353  VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
            +NR+    + L++K     G  L A+  ++I++LD N+  P F+  +Y   I ES P+  
Sbjct: 117  LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173

Query: 413  TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
                    TS  ++ A D DI    + E + +  +   +F+V  T  +  ++L   ++ +
Sbjct: 174  -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222

Query: 473  EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
            E+  Y   I A D         GV  +  + V+I+ +  N++ PT   +++ V    +  
Sbjct: 223  EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279

Query: 524  PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
            P  +V+  T  D D+G+NGEI +  I+ G   D F + K    +      E         
Sbjct: 280  PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337

Query: 576  GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
               Y LT+QA D   P ++ +++  VYI   P  +  P RF + +Y + ISE    G V+
Sbjct: 338  PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395

Query: 636  LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
              ++ +    D + Y +  G+    F ++  +G++   + L+    + Y L +T      
Sbjct: 396  AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450

Query: 696  DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
            +G   A V I + D ND+      P++D Y+  ++ V        V  V A+D D G NG
Sbjct: 451  EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505

Query: 751  QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
             + YS+ + N L  + +   G I T  +L+ E   + Y  +V A+D G+ +   S + + 
Sbjct: 506  YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565

Query: 807  IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
            I++ +++DNSP+F       ++  + P G  I  + A D+D    V Y+I S     FF 
Sbjct: 566  IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625

Query: 867  LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
            L+P +G L L +SL       +  +    + A D      P    ++V+           
Sbjct: 626  LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683

Query: 916  -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
                                              +N   P F K     + V  D   G 
Sbjct: 684  RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743

Query: 944  PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
             I  + A DAD       +V + + D       S F ++ ++G++   + ++ E T ++ 
Sbjct: 744  NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798

Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
            L +  +D G P  SS   + I V    +  P F Q+ Y    V+ L + G    +I   A
Sbjct: 799  LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855

Query: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
                   N  + YS+++  ++  F IN+ TG++YV   LD E++ +Y L+++A D  E  
Sbjct: 856  RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913

Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
                 V     T KV+++  D N+  P F    Y   V ED  + T +  ++  D D G 
Sbjct: 914  QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967

Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
               + Y L    + +    F ++  +G I+ +      ++ ++   V A D   KG    
Sbjct: 968  GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016

Query: 1236 ADVLVSVVNQLDMQVIVSN 1254
              V +S V+ ++++V+  N
Sbjct: 1017 RPVSLSSVSFVEVEVVDVN 1035



 Score =  174 bits (441), Expect = 6e-43
 Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)

Query: 469  VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
            ++RE Q  Y   +      ++ E    VNIQV+D ND  P F   +Y V +        S
Sbjct: 117  LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176

Query: 528  VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
            V Q+TA DAD GSNGE  Y         F ++ T+G+I+++  +       Y L + A D
Sbjct: 177  VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235

Query: 588  NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
                    N + +   +Y+ +   N  +P           + +      V ++       
Sbjct: 236  RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295

Query: 645  GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
            G+  + +I  GDP   F L++    L   K  +R+  D       Y L + A D G P  
Sbjct: 296  GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355

Query: 698  TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
             S      +     D  P+       ++S+ E      V  +    P+  I+ +   S G
Sbjct: 356  CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414

Query: 758  NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
                 F+I   +G I TA  LN   ++ Y+L V   +G +  +     + I + D +D++
Sbjct: 415  EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469

Query: 817  PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
            P F    Y   V E++P GT++L + A D D G N  ++Y I S  +   F ++ FTG +
Sbjct: 470  PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528

Query: 875  SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
            S    LD+E+ P+      F+V A D +G+         VT+ + ++ND  P+F K   +
Sbjct: 529  STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584

Query: 933  GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
            G+++ D   G  IT V A D D   L    V+Y++   +++ F Y    + + ++++   
Sbjct: 585  GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640

Query: 985  -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
                 +G    R+   +     +P +I       K+   +F   E  ++     K+L+  
Sbjct: 641  NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700

Query: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
                   L  G +         P F +       V E    G  +  I A    +  N  
Sbjct: 701  KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760

Query: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
            ++++I  GN +  F I+  TG + V  P+D E    Y+       L + + +L  P KS+
Sbjct: 761  VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813

Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
               + I ++D N++ PVF +  Y   + E + + T +++V+A DKD G+   + Y ++  
Sbjct: 814  WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871

Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
                  + F + + TG++  A       ++ +  ++ A D    G    + V + V    
Sbjct: 872  ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928

Query: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
                  + +P +   K +EDL
Sbjct: 929  VNDCSPAFIPSSYSVKVLEDL 949



 Score =  168 bits (426), Expect = 4e-41
 Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)

Query: 220  LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
            LN E +  Y +I++ + R ++L       T + + VLD +DL P+F             P
Sbjct: 117  LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160

Query: 280  LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
             TY   I E  TP   +   VT    A D D          G  Y       +     F 
Sbjct: 161  TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205

Query: 340  MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
            +HP +  +SL   +N D   ++DL I       K   +NG    A   +HIE ++E+  +
Sbjct: 206  VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263

Query: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
            P   + ++  + LE  P  A             +V +D D++D  + E+    +   D  
Sbjct: 264  PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309

Query: 450  SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
              F + + G  ++L   +  +R++         Y  ++ A D G  +    +  + + + 
Sbjct: 310  DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367

Query: 502  ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
              D  P  F +  YDV +     PG   ++++L+    D      + Y++  G     F 
Sbjct: 368  TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421

Query: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
            IN  +GLI  A  +  +    Y L V   +    A+      T+ IE     N   P F 
Sbjct: 422  INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473

Query: 618  QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
            Q +Y   ++E++ VG  +L + A+D+   E   ITY+I + +    F +++ TG+++  +
Sbjct: 474  QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532

Query: 675  ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
             LD ES+ + Y  I+ ASD G P    S   V I + +VNDN+P+F+    + +   +  
Sbjct: 533  ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592

Query: 732  ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
                +  V A D D     +     GN    F +  +  +    K   N  +++  + L 
Sbjct: 593  VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652

Query: 789  VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
            + ATDG             +H + S+ +           LA K+L               
Sbjct: 653  ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712

Query: 811  ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
                 I+   P F  S    V V+E+LP G  IL+I+A D D G N  V + I       
Sbjct: 713  LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772

Query: 864  FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
             F +   TG+L +L  +D E       +IT     +D+          +T+ V+D ND  
Sbjct: 773  CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828

Query: 924  PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
            PVF +  Y   +   +  GT I  V A D D        V Y V  D Q       F + 
Sbjct: 829  PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880

Query: 983  EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
              +G V     L+ E    + L + A D  E    + S  T+K+ +    +  P F    
Sbjct: 881  SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940

Query: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
            Y    + +L   GT++  +        +   + YS+V+ +    F I+  +G I ++  L
Sbjct: 941  YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998

Query: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
            DYE +  Y L V+A          R  S S+ + V +E+ D  EN H P F     +G V
Sbjct: 999  DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052

Query: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
             E++R+ TSVL+V A D+D+G    + Y +       G   F ++  +G+I  A +    
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109

Query: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
                +   V ATD     L    +V + V +  D   + S     P ++E   +D++ I
Sbjct: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168



 Score =  145 bits (367), Expect = 2e-34
 Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)

Query: 126  GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
            G      + +++ D NDN P F  + Y   V E T     + T       A D D G N 
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164

Query: 186  QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
            ++ Y +  +     S D+       +G I+L + L+ E ++ Y + ++A D  Q+  +  
Sbjct: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216

Query: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
            ++ TT+T+ VLD +D  P+F         RD     Y   +PE  +P        T  + 
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257

Query: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
                 ++I   ++   I Y I  G  +     F ++P+T  +S+ E ++ +  ++F LV+
Sbjct: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311

Query: 366  KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
            +A+      L A A ++I + D N+  P F+   Y   I E A VG ++           
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360

Query: 426  IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
            I+ + +D++   + ++H  +   D  + FTV    +   + + + +DRE    Y+  + A
Sbjct: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418

Query: 484  FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
             D G+   S    VNI + D NDN+P F   +Y   +  +   G S++QL   D D   N
Sbjct: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478

Query: 542  GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            G   ++ IL G + +  +    G++  A   +      Y L VQA D+  P +  ++   
Sbjct: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
            + + V+  +   P   P  ++ + + +    G V+  + ATD++  D +T+A+++ + + 
Sbjct: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594

Query: 660  VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
            +F ++   G I+ LG  LD   + +Y+L ++ SDGR
Sbjct: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626



 Score =  102 bits (253), Expect = 4e-21
 Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)

Query: 505  NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
            N   +   +   YV +  R G ++I L+       V  DE   G    E ++ A   F+ 
Sbjct: 49   NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106

Query: 559  NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
             +T G      G   I+ R     Y L V+ +      E       V I+VL  N+  P 
Sbjct: 107  IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156

Query: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
             F    YS+ I+E+  +   +  + ATD +    G+   Y     D   +F++  T+G++
Sbjct: 157  LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213

Query: 671  TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
            +L   L+ +  +RY L I A D      G    +STA + + +  +N++AP         
Sbjct: 214  SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273

Query: 725  LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
             S+ +E   A V      D D G NG++       G+  + F +   G      K+  R+
Sbjct: 274  FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330

Query: 781  VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
              D+      Y L + A D     + S L          D  P+ F    Y V + E  P
Sbjct: 331  QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390

Query: 834  AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
             G  +  ++     +  +V Y++   E   +F ++P +G +   R L+           T
Sbjct: 391  PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437

Query: 894  FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
               E + +  T   G   A VT+ ++D ND+ P F + +Y   V      GT + TV A 
Sbjct: 438  VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497

Query: 952  DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
            D D        + Y +  +        F + + +G + T   L+ E    I++ +V A D
Sbjct: 498  DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551

Query: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
             G P    S   V I + +  +     ++      +S     G  +  +SA  I++   +
Sbjct: 552  WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611

Query: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
             Y I+SGNE   F +N  +GV+ +   L        ++ LR+ A          S+ + +
Sbjct: 612  KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671

Query: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
             + +V SKS                          N    +++    N   P F K F  
Sbjct: 672  LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731

Query: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
               V ED  +  ++L++KA D D+G    + +      I +G     F ++  TG +K  
Sbjct: 732  DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786

Query: 1208 M 1208
            M
Sbjct: 787  M 787



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)

Query: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
            I+   ++  I Y IVSG+EE  F    +    +    +  +   S +L   +Q + L +V
Sbjct: 70   ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129

Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
              ++R        KV I++ D N+  P+F    Y   ++E   + TSV +V ATD D G+
Sbjct: 130  KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189

Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
                 Y       K   + F V   +G+I  +   +   ++ +  +++A D     YG  
Sbjct: 190  NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244

Query: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
            G+S  A + V +  +N+    + +V++VP      PT     ++DL +
Sbjct: 245  GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  314 bits (805), Expect = 4e-85
 Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            + +VV D NDN P F  ESY+  V+E   V + I         ATD D GPNG + Y I 
Sbjct: 808  LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                  T  DTF I   +TG + + + L+ E +  + + I+A D+A+    +  +T  + 
Sbjct: 862  -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            V + D +D  P F+P    PN R             ++  E+L    V   ++A D D  
Sbjct: 915  VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
                     + YS+L    +     F +   +  + +++ ++ +  Q ++L ++A +D G
Sbjct: 957  ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007

Query: 373  HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
             P+   +  ++E+    ++EN   P F+    +G + E APVG+ +         + + A
Sbjct: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058

Query: 429  LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
             D+D    +D E+   + D + V        T  +     +DRE    Y  ++ A D   
Sbjct: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116

Query: 487  VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
            V  S  + + I+V D NDN P   E  Y   +  +     SV+Q+ A D D  SN ++ Y
Sbjct: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176

Query: 547  EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            +I  G  QG F I+  TGLI T +  ++      + L V   DN  P   +++I  V ++
Sbjct: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234

Query: 605  VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
            +L   N + P+F Q  Y + + E  +           L ++ ATD++      I+Y+IE+
Sbjct: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293

Query: 655  GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
            G+    F +   TG+++  K          + I    +GRP  +ST  ++I    ++   
Sbjct: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350

Query: 715  PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
            P  +P          +V+E +  A +  V + +P  GI      + GN+++ F +    G
Sbjct: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
            +I  A  L+ E +  Y L V ATDG      + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465

Query: 829  EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
             E+    T ILQI A D D    + Y +   R P     F L P TG L     LD+EA 
Sbjct: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525

Query: 886  PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
               + ++T +V   D+   +    A + V V D ND+ P F+   YKG V   A  G+ +
Sbjct: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581

Query: 946  TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
              V A D D      + V Y ++        + F ++   G + T   L+      + L+
Sbjct: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636

Query: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
            V A D G P MS   +V+I V +     P+FT +EY    +SE  + G+ VG+++A +  
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694

Query: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
             S+VY I  GN  D F IN  +G I     LD+ET   Y L +Q  ++            
Sbjct: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745

Query: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
            S    V + +QDEN++ PVF +  Y G +SE A + + VL        ++A D D  + +
Sbjct: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805

Query: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
            ++ Y ++ P +      F +++ TG I T +       S F F V   D       G   
Sbjct: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856

Query: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
            +       + + VI  N  P +  K + + + +L  Y      G KV+            
Sbjct: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911

Query: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
               + SI     G+ FS+ DY    LTV
Sbjct: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938



 Score =  301 bits (771), Expect = 4e-81
 Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            +V + V   N +SP F    Y   + E  P+ T +      +   TD D G  G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
                 +  + D F I     G I   ++L+ E      + ++   +       +    T+
Sbjct: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             V + D +D  P F            R   Y+  I              T  ++ +  D 
Sbjct: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
            +    +D   I Y+I   + E       ++  +  ++  E +    ++ F   ++A  DN
Sbjct: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678

Query: 372  GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
            G P      L +++IL    Q P F+ P Y   + E  P+G  I       S   + +L 
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738

Query: 431  KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
            K       PE     N   S     Q+G    L L + +D E  + Y FSI A     + 
Sbjct: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787

Query: 491  EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
            E V    V+IQV DANDN+P F    Y+ ++  ++  G  VIQ+ A DAD G+NG++ Y 
Sbjct: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847

Query: 548  I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
            +     V     F IN  TG IT    ++      Y + V A+D+    E+     T  +
Sbjct: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904

Query: 604  EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
            +V   + N SPPRF   +Y   +SE    G V+  L  TD + + I    TY I  GDP 
Sbjct: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964

Query: 659  RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
              F +   +    + + K LDRE  D Y+L ITA+DG    +S A V + V D NDN+PV
Sbjct: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022

Query: 717  FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
             +  L  +    +      + Q+ ATD D   N ++ Y+ LG+    F++    G + T+
Sbjct: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
              L+RE +  Y L+V ATDG    R    ++ + + D++DN+P F+   Y + V EN   
Sbjct: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140

Query: 835  GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
            GT + +++A D D G N  + Y +        F+++  +G + L + LD E     +A  
Sbjct: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195

Query: 893  TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
            T  ++A D  G      AT TVIV   D+ND PPVF  R Y   V+ D + GT +  VYA
Sbjct: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254

Query: 951  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
               D      + + Y +           F ++  +G V    NL+ E +  + L V A D
Sbjct: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309

Query: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
             G P +S  ATV + V    +  P F+Q+ Y      +   + +++ V++  A    N  
Sbjct: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369

Query: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
            I YSI+ GN+  +F I+ + G + V   LD ET + Y L VQA       ++   P + N
Sbjct: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422

Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
            T  V I++ D N++ PVF +  Y   + E+  +  SVL++  TD+D+ +     +  I+ 
Sbjct: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482

Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
               E  + F V    G++ T+       + ++  QV   D      +GK    +S +  +
Sbjct: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531

Query: 1247 DMQVIVSNV-PPTLVEKKI 1264
            D++VI  ++ PP ++  +I
Sbjct: 3532 DIRVIEESIYPPAILPLEI 3550



 Score =  291 bits (746), Expect = 3e-78
 Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)

Query: 96   LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
            L++TG   DR+       +VV+V     K   + +  V+++V D+NDN+P F +  YYA 
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089

Query: 156  VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
            V   T VG  I         A D D G NG++ Y ++ +      ++ F+I PL   G I
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135

Query: 215  VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
             L+K+   +   + +++                    TV   DG +  P F   V+VP T
Sbjct: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173

Query: 275  RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                      A+P    P    E    I V  P+  +  +       +   + YSI  G 
Sbjct: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222

Query: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
            P      F ++  T  ++++ P++ + H  + L I+A         +  G H E+     
Sbjct: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272

Query: 387  --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
              D N+  P F   SY   + E++ +G         TS +++ A D D E  +     +F
Sbjct: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323

Query: 445  LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
             N   S         T  ++LL+ +D E+ + +T  + A DG     S  VIV + V D 
Sbjct: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383

Query: 503  NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
            NDN P F +  Y+  +      G  V  + A DAD     ++ Y IL G     F+I+  
Sbjct: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443

Query: 562  TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
            TG+IT++      +   Y+L +  +D         S   V++ V+  N  S P F Q  Y
Sbjct: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497

Query: 622  SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
             +E++E   +  +++ ++ TD  GDS     +TY I N   +  F ++E   I TL K L
Sbjct: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554

Query: 677  DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
            DRE+  ++ I +   +       +  TVN+++TD NDNAP F                  
Sbjct: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614

Query: 736  VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
            V +V A+D D G N  + Y++         NL     +G I T   L     +++   V 
Sbjct: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674

Query: 791  ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
            A D     + S + + +K+L  +   P F+   YT  V E++P GT I  I A+      
Sbjct: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734

Query: 851  NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
                +  +PE      F +   +G L L +SLD+E     + SI  L         M   
Sbjct: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792

Query: 909  IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
            +  V++ VKD ND  PVF    Y+  +  +   G+ +  + A DAD       +V Y +D
Sbjct: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849

Query: 969  DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
              Q       F +  ++G + T   L+ E    +++ VVA D GE + +SS+A V + V 
Sbjct: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909

Query: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
               +  PRFT E Y+   VSE   +G ++ ++S     +  IN+ + Y I  G+    F 
Sbjct: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968

Query: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
            +  I     +YV  PLD E R +Y+L + A             + S+ A V +++ D N+
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018

Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
            + PV +K  Y   + ED      ++++ ATD D  + + + Y L    +  G E F +  
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074

Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
             TG +KT+       ++ +   V ATD  G+
Sbjct: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105



 Score =  288 bits (738), Expect = 2e-77
 Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)

Query: 116  VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
            ++V   ++K  T    +V + V   N N P F   +Y A  +E  P+GTT+ +       
Sbjct: 436  LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486

Query: 176  ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
            A D D+G NG + Y I      P + D F      TG +   + L+YE   R + + I+A
Sbjct: 487  AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540

Query: 235  NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
            +D    L  RR      T+ + + +D  P+F              +  +  IP +L   E
Sbjct: 541  SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586

Query: 294  ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
            ++        + AID D       +   + Y I  G   D   FF ++P +  LSL   +
Sbjct: 587  QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630

Query: 354  NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
                  K     L I A        P +  + +                      ++L  
Sbjct: 631  MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690

Query: 389  NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
            N        +  +F   S   +I +   + P G  + ++  + S + I     D++   +
Sbjct: 691  NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749

Query: 439  PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
             +L   +   N+ +      +TG+   L +L P+DRE    YT +IT +D G+ Q++   
Sbjct: 750  GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806

Query: 494  IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
            ++++ V+DANDN P F + SY V V  D      +IQ+ A D D G NG +TY I+    
Sbjct: 807  LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866

Query: 554  GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
              F I+  TG++ IA  ++  +   ++L ++A D A   E      TV ++V L   N +
Sbjct: 867  -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923

Query: 613  PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
            PP F    Y +++ E +  G V++ L+A D    +   + Y+ +++G+    F++ + +G
Sbjct: 924  PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981

Query: 669  ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
             + + + LD E    Y L + A D G+P   +ST  V + V DVN+N   PVF  ++ + 
Sbjct: 982  AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041

Query: 725  LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
                +    + V  V A D DA  +G++ YS+  G+   +F+I    G I T+ +L+RE 
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
              +Y L V ATD  V P  S + + I+V D++DN+P  +   Y   + EN P   +++QI
Sbjct: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161

Query: 842  EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
            EA D D  +N  + Y+I S   + FF++HP TG ++   R LD E   +    +T     
Sbjct: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220

Query: 899  FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
                G+ P   IA V V + D ND  P F ++ YK  +     PD  +     P+  V A
Sbjct: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276

Query: 951  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
             D D    P + + Y ++D         F +E  +G V ++         I  L + A D
Sbjct: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329

Query: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
            +G P  SS+  + I  +    P   P   +E +    V E      M+GVIS       +
Sbjct: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389

Query: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
             + I  GN +  F ++  TG I V  PLD E +++Y L V+A D    +L          
Sbjct: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439

Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
              +V+I++ D N+H P F    Y   + ED    T +L++ A D+D  N  +   +    
Sbjct: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498

Query: 1187 PIKEGKEGFVVETYTGLIKTA 1207
            P+   K  F ++  TG + T+
Sbjct: 1499 PLSLKK--FRLDPATGSLYTS 1517



 Score =  258 bits (659), Expect = 3e-68
 Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)

Query: 118  VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
            V+ + K        +VR+ V D ND  P F   SY  ++ E T + T+I         AT
Sbjct: 120  VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174

Query: 178  DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
            D D G NG+  Y  +   D    + T       +G IVL  RL+Y +   Y + I A DR
Sbjct: 175  DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227

Query: 238  AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
               L  +   ++   LTV +   ++  P+     L P+  D                   
Sbjct: 228  GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269

Query: 296  NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
            +P      +   DQ  N    S       SI+ G      R     P + E  +  +  +
Sbjct: 270  DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323

Query: 354  NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
            + D H   ++L ++A +D G P P F+    +H+           F    Y+  I E AP
Sbjct: 324  DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381

Query: 410  VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
                +    ++   S LR V           P    F  +Y           T  +++L+
Sbjct: 382  PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424

Query: 468  PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
            PV R++   +   +T  D    ++   V ++V+ AN N P F + +Y      ++  G +
Sbjct: 425  PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481

Query: 528  VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
            V+ L+AVD DEG NG +TY I       F I+  TG ++ +  ++  ++ R Y L ++A+
Sbjct: 482  VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541

Query: 587  DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
            D   P  R    + T+ +  L   N + P F ++     I   + VG  +  + A D  E
Sbjct: 542  DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598

Query: 645  GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
               + Y IE G+    F+L+  +G+L+L ++L          + L ITA+DG    T   
Sbjct: 599  LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657

Query: 702  TVNIVVT-------------------------------------------DVNDNAPVFD 718
             +NI V                                             VN + P F 
Sbjct: 658  YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717

Query: 719  PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
              LP  + V E +   + V  + +TD D G NG++ Y++  GN ++ F I    G +   
Sbjct: 718  STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
              L+RE  D Y L +   D  +  + +   L + V+D +DN P F   +Y V V E+   
Sbjct: 778  SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837

Query: 835  GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
             + I+Q+EA D DLG N  V+Y I +      F++   TG +++ R LD E     E S+
Sbjct: 838  HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893

Query: 893  TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
               +EA D     P   +TV V V  +D+ND PP F    Y+  V  D  +GT I  ++ 
Sbjct: 894  K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949

Query: 951  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
            E  DP    + +VRY + D    +    F+V++ SG V     L+ E   ++ L V A D
Sbjct: 950  EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005

Query: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
             G+PV +SS+  V++ V      LHP     F ++      V E A  G++V  +SA   
Sbjct: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061

Query: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
             A  +  I YSI  G+    F I   TGVI  +  LD E+ + Y L V A    VV    
Sbjct: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117

Query: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
                 S+  ++YIE++D N++ P   +  Y   + E++    SV++++A D D+ +   +
Sbjct: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174

Query: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
             Y++         +GF  +   TGLI  T+      ++     +V  TD+     S  A 
Sbjct: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230

Query: 1238 VLVSVVNQLD 1247
            V+V ++++ D
Sbjct: 1231 VIVKILDEND 1240



 Score =  258 bits (658), Expect = 4e-68
 Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)

Query: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
            F ++  T  +S+LEPV R     F+L +           A   + +++L  N+  P FT 
Sbjct: 411  FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465

Query: 398  PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
             +Y+    E+ P+G T+         + + A+D D E       +   N     F +   
Sbjct: 466  TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514

Query: 458  GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
              T  ++  + +D E   + YT  I A D     +    V+  I + + NDNTP F +I+
Sbjct: 515  -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573

Query: 514  YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
             +  +  D+  G+ +  ++A+DADE     + Y+I  G + DF  +N  +G++++   + 
Sbjct: 574  CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631

Query: 573  MIVGRT---YALTVQAADN---------------------------------------AP 590
              +G     ++L + A D                                        A 
Sbjct: 632  DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691

Query: 591  PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
                +  +  ++ +    N   P     L   +++ E   VG+ ++ + +TD +      
Sbjct: 692  KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751

Query: 648  ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
            + YA+  G+    F +   TG+L +   LDRE+TD+Y L IT  D G P   +   +++V
Sbjct: 752  LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811

Query: 707  VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
            V D NDN P F  + Y    + V E+ E ++ + QV+ATD D G NG V YS+    + F
Sbjct: 812  VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868

Query: 764  RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
             I S  G +  A  L+RE++  + L + A D A   P+  ST+ + + + D++DN P F 
Sbjct: 869  SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928

Query: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
               Y V V E+LP GT I+ +EA D DLG   S ++R   + H    F +   +G + ++
Sbjct: 929  PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986

Query: 878  RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
            + LD+E    ++      V A D     P  +++   V V V D+N+  +PPVFS  + K
Sbjct: 987  QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040

Query: 933  GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
            G V  DA  G+ + TV A D D        +RY + D        +F++ E++G + T  
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095

Query: 993  NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
             L+ E T+ + L V A D G   +SS   + I V    +    T E    P + E + K 
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155

Query: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
              V  I A    ++ N  ++Y I SGN +  F I+  TG+I      LD E +  ++   
Sbjct: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212

Query: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
                LEV + +   P KS  A+V ++I DEN++ P F +KFY   + E        +AR 
Sbjct: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268

Query: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
               +  V ATDKD G  + ++Y      I++G E   F +E  TG++ +
Sbjct: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311



 Score =  249 bits (637), Expect = 1e-65
 Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V++ + D NDN PTF   +Y   V E  P GT I         A D D G +GQ+ Y + 
Sbjct: 913  VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
             + +     D       L+G + + ++L++E K  Y + ++A D+ + ++   ++T  + 
Sbjct: 968  DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            V+V+D ++               +  P  + + + +    E+     +   + A D+D  
Sbjct: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064

Query: 313  IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                  R G I YSI  G+       F +   T  +   + ++R+    + L + A    
Sbjct: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115

Query: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
              PL +F  ++IE+ D N+ +P  + P Y   I+E++P   ++         ++I A D 
Sbjct: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166

Query: 432  DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
            D          +   +    F++  +TG+    T  + +DRE+Q  +   +T  D     
Sbjct: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224

Query: 491  EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
            +  I  V ++++D NDN P F +  Y + +    +P        + +  + A D DEG N
Sbjct: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284

Query: 542  GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
             EI+Y I  G + G F I   TG+++         G    L+++A DN  P  +++S   
Sbjct: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340

Query: 601  VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
            ++IE +  P  +  P  F +  ++  + E+  V A ++ + + +  G  + + I  G+  
Sbjct: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399

Query: 659  RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
              F++ + TG + + K LD E    Y L + A+DG    T    V I V D ND+ P F 
Sbjct: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457

Query: 719  PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
                  +   +      + Q+ A D D     ++ Y+L +  +      FR+  + GS+Y
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515

Query: 773  TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
            T+ KL+ E    + L V+  D  V  + +   + + V D +D++P FT S+Y   V E+ 
Sbjct: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575

Query: 833  PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
              G+ +LQ+ A D D G N  V Y I S  + + F + P  G +   + LD       +A
Sbjct: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631

Query: 891  SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
                +V+A D        I +V + V   ++  P F+ + Y   ++     G+ +  V A
Sbjct: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691

Query: 951  EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
                      S V Y + D         F++   SG +IT+  L+ E   I+ L++    
Sbjct: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737

Query: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
             G  +   S    +LV    E    P F Q EY    +SE A+  ++V        VI A
Sbjct: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796

Query: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
            A      N  +VY IV  +    F I++ TG I+    LDYE  + +   VQ   +    
Sbjct: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856

Query: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
                       A V + + D N+ PPVF K  Y   +         V+ V ATD D+  +
Sbjct: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911

Query: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
            S + Y +         EG + E ++   KT  L        RS ++  V A+D    GL+
Sbjct: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963



 Score =  243 bits (620), Expect = 1e-63
 Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
            V + ++D NDN+P F    Y   ++E   + + + T  +      A D D   N  + Y 
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810

Query: 191  IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
            I     +P+ +  F I    TG I     L+YE+ + +   +Q +D              
Sbjct: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864

Query: 251  LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
            +TV V+D +D  P+F            +PL Y+A+   L  P      ++T  + A D D
Sbjct: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907

Query: 311  RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
                  S    ++YSI  G   +    F M  +T  L++          +++L ++A   
Sbjct: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957

Query: 371  NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
                   FAGL    I + +       FT   Y   + E++    T++    + +P+   
Sbjct: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009

Query: 428  ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
              +       +P+    ++  + V + T T          P DRE+Q+ +   +      
Sbjct: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054

Query: 488  QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
            +E +P     V+V + V D NDN P F  + Y   V  D   G  +  +TAVD D G NG
Sbjct: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114

Query: 543  EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
            E+ Y +        +G  G+  + K   L T+         + Y +TV A D   PA   
Sbjct: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166

Query: 596  NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
              I  + +      N++ P F +  YS EI+E+++V + ++++QA   EG  + Y+I +G
Sbjct: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
            DP   F ++  TG++ +   LD E+   Y L I A+D      +   V+I+V D+NDN P
Sbjct: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281

Query: 716  VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
            VF     ++ +V   EA+     V QV+ATD D+  N  + Y + GN    ++ F + S+
Sbjct: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338

Query: 769  GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
              + + ++ L+ E    + + V A DG +    S + + + V D++DN P+F    Y   
Sbjct: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398

Query: 828  VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
            + E+ P G  +  ++A D D      + Y I S      F +   TG ++L     +   
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458

Query: 886  PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
            P    +++     F            V V V   N + P F +  Y+  +A +A   T +
Sbjct: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511

Query: 946  TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
              V   D D  G+      + V+D    +    F + E  G++ T   L+ E     +  
Sbjct: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565

Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
            + ++A D G  V   +  V IL       P+F   +Y    +   A KGT V  + A+  
Sbjct: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623

Query: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
                N  I Y+I + +E  ++   IN ++GVI        L+ E  T +V  V   S   
Sbjct: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680

Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
                   PSK +   VY++I       P F + FY   VSED  + T +  ++A    T 
Sbjct: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733

Query: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
             YS++       P     E FV++  +G +K      +    +++F ++A    DD+   
Sbjct: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788

Query: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
            +    DV + V +  D   +  + P               + ++ E +PG   V++
Sbjct: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830



 Score =  240 bits (613), Expect = 7e-63
 Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            E+ I V D NDN+P      YY  + E +P   ++         A D D   N ++ Y I
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
                     +   +  L+ T +    ++L+ E +  + + +   D   N +  ++T   +
Sbjct: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             V +LD +D  P FL               Y+  +PE   P+        P    I  D+
Sbjct: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
            +  P ++   I YSI  G   ++ +FF + P+T  +S     ++ F    ++D++     
Sbjct: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328

Query: 370  DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
            DNG P   +   LHIE + +         PS +    E +    T+ +S  +   + +++
Sbjct: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381

Query: 429  LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
            ++        P + L+ +    +Y S F V +   T  + + +P+D E++  Y  ++ A 
Sbjct: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432

Query: 485  DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
            DG   +    V I+V+D ND+ P F    Y+V +  D  P   ++Q++AVD DE    ++
Sbjct: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489

Query: 545  TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
             Y +       +   F ++  TG +  +  ++      + LTV   D   P +R  +   
Sbjct: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549

Query: 601  VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
            V +      N   P F    Y   + E+  VG+V+L + A D++      + Y+IE+G+ 
Sbjct: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606

Query: 658  QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
               F +    G +   K LDR +   Y L++ A+D G P  +   +V I VT  ++ +P 
Sbjct: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666

Query: 717  FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
            F     +  SV   E     +FVG V A          V Y +  GN  + F I   +G+
Sbjct: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718

Query: 771  IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
            I T   L+ E    Y L++  T+ A     +  T+ + + D +DN+PVF  + YT L+ E
Sbjct: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776

Query: 831  NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
            +    + +L        I A D D  +N  + Y I  P V  +FA+   TG +  + SLD
Sbjct: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836

Query: 882  YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
            YE    + +   F V+  D+ GT        A VTV V D+ND PPVF+K +Y+  +   
Sbjct: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891

Query: 939  AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
              KG  + TV A DAD      S++ Y + +         F ++  +G +   V    + 
Sbjct: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944

Query: 999  TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
             + ++L V A D      +   +VKI V    E   +FTQ+ Y    V E +T+   + V
Sbjct: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000

Query: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
            I+A    IN+ + Y I+  N +  F I+  +GV+   G P D         R Q ++ +V
Sbjct: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049

Query: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
            V+        S  A V ++  ++D+N++ PVF    Y   V  D  +   +  V A D+D
Sbjct: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109

Query: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
            +G    + Y L     KE  E F +     + +K       + + Y    V+A D     
Sbjct: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163

Query: 1232 LSGKADVLVSVVNQ 1245
             S +  V ++V+N+
Sbjct: 2164 FSAEVIVPITVMNK 2177



 Score =  219 bits (557), Expect = 2e-56
 Identities = 281/1199 (23%), Positives = 500/1199 (41%), Gaps = 125/1199 (10%)

Query: 111  IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
            ++++ V+ +   K V   +  Y EV +V  + N + P F       TV E  PVG+ + T
Sbjct: 996  VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055

Query: 169  GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 228
                   A D D   +G+I Y I+    D +    F+I    TG I    RL+ E  + Y
Sbjct: 1056 -----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIETSDRLDRESTSHY 1105

Query: 229  FVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE 288
            ++ + A D+        ++   + ++V D +D  P     V  P   +            
Sbjct: 1106 WLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME------------ 1150

Query: 289  LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELS 348
              +P++++ +     I+A D D      S    ++Y I  G P+    FF +HP+T  ++
Sbjct: 1151 -NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLIT 1197

Query: 349  LL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 407
                 ++R+   +  L +    +   P    A + ++ILDEN+  P F    Y+  + E 
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER 1257

Query: 408  APVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYL 463
                    +      PL  ++A DKD  +  + E+   +   N++   F   +TG+    
Sbjct: 1258 EKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312

Query: 464  TLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DM 522
                  + +       SI A D  +  +     + +   +   P+   IS++   +T  +
Sbjct: 1313 RFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTV 1367

Query: 523  RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
               D V  +  V + E     + ++I  G     F ++K TG I +A  ++      Y L
Sbjct: 1368 MESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427

Query: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
            TV+A D          +  V+I+V+  N+   P+F    Y + I E       +L + A 
Sbjct: 1428 TVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPETEILQISAV 1481

Query: 642  DR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 696
            D+ E + + Y +++  DP   + F L   TG L   + LD E+  ++ L +   D   P 
Sbjct: 1482 DQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPV 1541

Query: 697  GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
              + A + + V+D ND+AP F     +          + V QV A D D G N +V YS+
Sbjct: 1542 KRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI 1601

Query: 757  --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
              GN  N F I    GSI TA +L+R  +  Y+L+V ATD    P     ++ I V   D
Sbjct: 1602 ESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661

Query: 814  DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
            + SP FT+  Y+V + E +  G+ +  + A      ++V Y I+       F ++P +G 
Sbjct: 1662 NASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNTGDAFDINPHSGT 1718

Query: 874  LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKDMNDYPPVFSKRI 930
            +   ++LD+E  P         +    I GT   G++T T +   ++D ND  PVF +  
Sbjct: 1719 IITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAE 1769

Query: 931  YKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 983
            Y G+++  A   + + T       + A DAD     A  V + V+    P   + F ++ 
Sbjct: 1770 YTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE----PSVHTYFAIDS 1824

Query: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHPGEIPRFTQEEYR 1041
             +G + T ++L+ E T+IF   V   D G P + +  +A V + V+   + P    +   
Sbjct: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884

Query: 1042 PPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1097
               +     KG  V  ++A   + S    ++YSI  GN  + F ++  TG + V      
Sbjct: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT-- 1942

Query: 1098 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1157
            + R+ Y L V+A               +    V I +++       F +  Y   V E++
Sbjct: 1943 QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFTQDVYSAVVKENS 1992

Query: 1158 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK-TAMLFHNMRRS 1216
                ++  + A          + Y ++ P  +     F +   +G++  T   F   ++ 
Sbjct: 1993 TEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLSTTGTPFDREQQE 2045

Query: 1217 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYV 1275
             F   V  T+++         V V V +Q D   +  N+P   V K   ++  ++ RYV
Sbjct: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI-RYV 2103



 Score =  216 bits (549), Expect = 2e-55
 Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)

Query: 156  VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
            V E  PVG+++         +TD+D G NG++ Y +    +D      F I  M TG + 
Sbjct: 726  VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775

Query: 216  LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
            +   L+ E   +Y + I   D       ++     L V V+D +D  P FL         
Sbjct: 776  ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823

Query: 276  DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
                   ++   E+   +E++  I+   ++A D+D     P+    + YSI+  T     
Sbjct: 824  ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867

Query: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
              F +   T  +++  P++R+   +  L I+A          F+ + +++   D N+  P
Sbjct: 868  --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925

Query: 394  YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
             F  P+Y+  + E  P G  I         + + A D D+  +      L L+     F 
Sbjct: 926  TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975

Query: 454  VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
            V +  ++  + ++Q +D E++Q Y  ++ A D    V  S    V ++V+D N+N   P 
Sbjct: 976  VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033

Query: 509  FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
            F        V  D   G  V+ ++A D D   +GEI Y I  G+  G F I + TG+I  
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093

Query: 568  APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
            +  ++      Y LTV A D        +S   +YIEV   N+ + P+  + +Y  EI E
Sbjct: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150

Query: 628  AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
                   ++ ++A D +    D + Y I +G+PQ  F++   TG++ T  + LDRE  D 
Sbjct: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210

Query: 684  YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
            +IL +T +D G P  ++ A V + + D NDN P F        LP      + E NA   
Sbjct: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269

Query: 736  -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
             +  V ATD D G N ++ YS+  GN +  F I     + ++ + +    +Y  L + A 
Sbjct: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328

Query: 793  DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
            D     + ST  L I+ +     S  P+ F  S +T  V E+ P    I  I  +    G
Sbjct: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386

Query: 850  ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
              + + I        F +   TG + + + LD E    Q+++    VEA D   T+   +
Sbjct: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439

Query: 910  ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
              V + V D ND+ P FS   Y+ ++  D    T I  + A D D      +++ Y +  
Sbjct: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495

Query: 970  VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
             + P     F ++  +G + T   L+ E      L V+  D   PV  + A + + V   
Sbjct: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555

Query: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
             +  P FT   Y+   V E A  G++V  ++A       N  ++YSI SGN  ++F I+ 
Sbjct: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614

Query: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
            + G I     LD   +  Y L V+A        +   P  S    V I +   +N  P F
Sbjct: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667

Query: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
              K Y   +SE   + + V  V A  + +          ++  IK+G  G  F +  ++G
Sbjct: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717

Query: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
             I T  A+ F  +      + +I       GLS    VLV + ++ D
Sbjct: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760



 Score =  179 bits (453), Expect = 3e-44
 Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)

Query: 410  VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
            VG  +   + +T P   +R   +  D E+    E ++ L D+  +   T+ G T  L   
Sbjct: 53   VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108

Query: 467  QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
               +RE +  YT  + A +     E    V +QV+D ND  P F   SY V +  +    
Sbjct: 109  ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165

Query: 526  DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
             S+ +++A DAD G+NGE  Y         F I+ T+G+I +   ++ +  + Y + + A
Sbjct: 166  TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224

Query: 586  ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
            AD        + I      TV+IE    N  +P      +   E+        V ++   
Sbjct: 225  ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282

Query: 641  TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
                GD  + +I  GD        R F  S+   +  +G  +D +S    Y L + A D 
Sbjct: 283  QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341

Query: 693  GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
            G P   S+  V  V +      PV             + P N  VV  +A      ++  
Sbjct: 342  GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401

Query: 743  DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
                   G+  +SL N+N        G I     + R+   ++EL V  +D     R ++
Sbjct: 402  FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446

Query: 803  LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
              + +KVL  + N P FT + Y    +EN+P GTT++ + A D D G N  V+Y I +  
Sbjct: 447  TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504

Query: 861  VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
            + H  FA+  FTG +S   +LDYE  P      T  + A D    Y      +AT+T+  
Sbjct: 505  LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559

Query: 917  KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
             ++ND  P+F K   +G +  D   G  ITTV A DAD   L    V+Y+++        
Sbjct: 560  NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612

Query: 977  SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
              F +  +SG +                    IT  +     T ++  + VA        
Sbjct: 613  DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672

Query: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
               + G   M +   ++   LH  GE              IP+F         V E    
Sbjct: 673  QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732

Query: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
            G+ V  +++       N  +VY++  GNE+  F I+  TG++ +  PLD ET   Y    
Sbjct: 733  GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788

Query: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
               +L + + +L +P K+    +++ + D N++PP F ++ Y   VSED  + + +++V+
Sbjct: 789  ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845

Query: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
            ATDKD G    + Y ++        + F +++ TG++  A       +     ++ A D 
Sbjct: 846  ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900

Query: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
              +    +  +  +VV ++ ++ +  N    +PP    K  EDL E
Sbjct: 901  ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942



 Score =  170 bits (431), Expect = 9e-42
 Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
            V + V D NDNSP  +   Y  T+ E    G  I         ATD D   N +I Y + 
Sbjct: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063

Query: 192  -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
                   + NPD              TG +     L+ E++  Y ++++A D        
Sbjct: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104

Query: 245  RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
            R    ++ + + D +D  P F                  +A P   T  E   P  +   
Sbjct: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146

Query: 304  IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
            +QA D D  +        ILYS++          F ++  +  + L +P++R+    + L
Sbjct: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197

Query: 364  VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
             +KA  D G P  L A   + + +LD N+  P F    Y          GAT+S+ + + 
Sbjct: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
            T  L++ A  +DIE   +    +   +    F++     T  + +++ +D E    Y  +
Sbjct: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304

Query: 481  ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
            + A DG   S  +   VN+ V D NDNTP F + +Y   +  D     SVI + A DAD 
Sbjct: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364

Query: 539  GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
             SN  I Y I+ G QG  F I+   G + +   ++      Y LTVQA+DN  P   R +
Sbjct: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422

Query: 598  ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
              TV I+V   N+ +P  F +  YS+ I E   VG  +L L  TD +    G    + I 
Sbjct: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481

Query: 654  NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
             G+ ++ F ++   G+L    A+ R+  D Y+L +  +D G+P  +S   ++I V + + 
Sbjct: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540

Query: 713  NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
              P   P      S  EE +   +G++ ATD D  +   + YSL    +NLF ++S G  
Sbjct: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598

Query: 772  YTAVKLNREVRDYYELVVVATDG 794
              A K   ++  Y  L V  TDG
Sbjct: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619



 Score =  142 bits (359), Expect = 2e-33
 Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)

Query: 126  GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
            G      + + + D NDN+P F  + Y  TV E T  GT +         ATD D G N 
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158

Query: 186  QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
            +I Y +  + D   S +       L+G I L K L+ E +  Y + ++A D  Q L  R 
Sbjct: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210

Query: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
            T T T+ V VLD +D  P+F                Y A + E       + ++ T  +Q
Sbjct: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251

Query: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
                 R+I+  ++   I YSI+ G        F +  +T  + ++E ++ +   ++ L +
Sbjct: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305

Query: 366  KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
            +A       L   A +++ + D N+ +P F+  +Y   I E A +  ++           
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354

Query: 426  IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
            I  +  D +   +  +H  + D     + T   +   + + + +DRE    YT ++ A D
Sbjct: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414

Query: 486  --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
                       VNI V D NDN P F   +Y V +  +   G SV+QL   D D   NG 
Sbjct: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474

Query: 543  EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
               + I+ G           G++  +  ++      Y L V+ ADN  P  + +S+  + 
Sbjct: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532

Query: 603  IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
            I V+  +   P   P  ++     E    G V+  + ATD++  D++TY++   DPQ   
Sbjct: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
            +F++S T G L   K LD     +Y+L ++ +DG+    +  TV+I
Sbjct: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631



 Score =  129 bits (324), Expect = 2e-29
 Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)

Query: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
           +NR+    + L++KA + N + + A   + +++LD N+  P F+  SY   + E+  +  
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166

Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
           +I+         R+ A D DI    + E +    D T +F +  T  +  + L   +D  
Sbjct: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213

Query: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
           E + Y   I A D         G+     + V+I+   AN+  P    ++       D  
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270

Query: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
           P  +++  T  D D+G+NG+I    +V   GD +    T  +   PG     V+ I G  
Sbjct: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324

Query: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
                  Y LT+QA D   P +  +S+  +++   P     P +F + +Y  EISE    
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382

Query: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
              ++ ++A       + Y  ++   +  F+L+  TG++++ + + R+    + L +T S
Sbjct: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441

Query: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
           D +    ++  V + V   N N P F     +            V  + A DPD G NG 
Sbjct: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497

Query: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
           V YS+ N N++ F I    G++ T+  L+ E+    Y L + A+D  +  R     LA I
Sbjct: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557

Query: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
            + +++DN+P+F        +  +L  G  I  + A D D    V Y+I +     FF+L
Sbjct: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617

Query: 868 HPFTGELSLLRSL 880
           +P +G LSL RSL
Sbjct: 618 NPNSGVLSLKRSL 630



 Score =  103 bits (256), Expect = 2e-21
 Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)

Query: 611  QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
            Q+P +F  L Y++ + E           V + +  T    + + Y I +GD + +F   E
Sbjct: 29   QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87

Query: 666  TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
                      I T G     L+RE  D Y LI+ A +   +  +   V + V D ND  P
Sbjct: 88   YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147

Query: 716  VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
            +F P      LP N ++        + +V ATD D G NG+ +YS  +  ++F I  ++G
Sbjct: 148  LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
             I    +L+      YE+ ++A D  +    S+       L + +   ++ +PV T  T 
Sbjct: 203  VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
            +    +  PA   +      D D GAN        +    ++ F  +  F G    ++  
Sbjct: 263  SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319

Query: 877  LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
            +  +D+++ P         ++A D  GT PP  ++V VI      +   P  F K +Y+ 
Sbjct: 320  IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374

Query: 934  MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
             ++  A   TP+  V A       +PA S +RY       P  A  F +  ++G +    
Sbjct: 375  EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424

Query: 993  NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
             +  +    F+L V   D      S+   VK+L  +    P FTQ  Y+     E    G
Sbjct: 425  PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479

Query: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
            T V  +SA       N  + YSI + N    F I++ TG +  +  LDYE     Y LR+
Sbjct: 480  TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538

Query: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
            +A       ++  +P +     +  I + + N++ P+F+K    G +  D  +   +  V
Sbjct: 539  RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591

Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
             A D D         +L+   I+ G E   F +   +G++   ++ M     + S+   +
Sbjct: 592  SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644

Query: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
            + ATD          ++ V+  ++L ++Q   + V   L EK ++
Sbjct: 645  ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score =  293 bits (750), Expect = 1e-78
 Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)

Query: 138  RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
            R RN N+ P F+  SY ATV E  P GT +         A D D+G  G++EY +     
Sbjct: 171  RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224

Query: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
            D  SN  F +   +TG +   + L+ E K+ +   + A D       RR+   TLT+ V 
Sbjct: 225  DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280

Query: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
            D +D  P+F                 Q     LR   E+   ++T  ++A D D    PP
Sbjct: 281  DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320

Query: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
            +    ILY +L G+       F + PR+  +    PV+R+  + + L ++A      P P
Sbjct: 321  N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378

Query: 377  --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
                A + + + D+N+ +P F+   Y   + E    GA +         LR+ A D+D  
Sbjct: 379  RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429

Query: 435  DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490
                    +   +    F +  QTG    L ++ P+D E  + YT  + A DG +    +
Sbjct: 430  SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486

Query: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549
               +V +QV+D NDN P F    +   V   +  G  V+ + A+DAD G N  + Y +  
Sbjct: 487  VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546

Query: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
            VG    F IN  TG I++A  ++      Y+  V+A D+  PA   ++  +V +  +  N
Sbjct: 547  VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606

Query: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667
            N   P F Q  Y++ ++E   VG  ++ + A DR+  S ITY I +G+ +  F+++  + 
Sbjct: 607  N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663

Query: 668  -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725
             G+++L   LD +   +Y+L +TASDG    T+   VN  VTD N + PVF   +   N+
Sbjct: 664  GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721

Query: 726  SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784
            +  +  A   V  + ATD D G N ++ Y + +    FRI ++ G++ T  +L+ E +  
Sbjct: 722  N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780

Query: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
            Y L + A D  +  +  T  L I V D++DN+P F   +Y   V E++P  T++LQI A 
Sbjct: 781  YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840

Query: 845  DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
            D D G N  V Y  +   +    F +   +G +  LR L      D+E    +++ A+ +
Sbjct: 841  DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894

Query: 902  YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
               MPP      VTV V D+ND PPVF +  +   V  ++  G  +  V A D D     
Sbjct: 895  DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952

Query: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
             +++ Y++ +   P    +F+++  SG +   V+L+ E    + LV+ A     P++ S 
Sbjct: 953  NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006

Query: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073
            ATV + +L    +P  +  F             +  G  +G + A    I+ S+ YS   
Sbjct: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066

Query: 1074 GNEEDTFGINNITGVIYVNGPLD 1096
            GNE     +N  TG + ++  LD
Sbjct: 1067 GNELSLVLLNASTGELKLSRALD 1089



 Score =  292 bits (747), Expect = 2e-78
 Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)

Query: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443
            N +P F  PSYQ  + E+ P G  ++          + A+D D      +E T D     
Sbjct: 176  NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226

Query: 444  FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501
              N + S+  VT       +T  + +DRE + T+ F +TA D    + S    + I V D
Sbjct: 227  RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281

Query: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
             ND+ P F +  Y   +  ++  G  V+ + A D D   N  I Y +L G+ G     F 
Sbjct: 282  TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341

Query: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
            I+  +G+I     V+     +Y LTV+A+D       R++   V++ V   +N + P+F 
Sbjct: 342  IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400

Query: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
            +  Y +++ E +  GA +L + A+DR+  S   + Y+I +G+ +  F L   TG L +  
Sbjct: 401  EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460

Query: 675  ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
             LD E+T  Y L + A DG   P    +  V + V D+NDNAP+F    P   +V+E   
Sbjct: 461  PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519

Query: 733  NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788
              + V  V+A D DAG N ++ Y L    + F  T N   G I  A +L+RE  D+Y   
Sbjct: 520  LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579

Query: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
            V A D       ++ ++++ VLD++DN+P FT   YTV + E+   GT+++ + A D D 
Sbjct: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639

Query: 849  GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
             + ++Y+I S   ++ F++   +G   +SL   LDY+     E      V A D  GT  
Sbjct: 640  HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692

Query: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
               A + V V D N + PVF    Y   V  D   GT +  + A D D      +R+ Y 
Sbjct: 693  QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750

Query: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026
            ++D   P     F ++ D+G V T+  L+ E    + L + A D+G P  S +  ++ILV
Sbjct: 751  MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805

Query: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080
                +  P+F ++ Y+   V E     T V  ISA    + +N  + Y+   G++ D  F
Sbjct: 806  NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
             + + +G++     LD E    YVLR  A        +  +P      +V + + D N++
Sbjct: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
            PPVF++  +   V E++ +  +V RV ATD D G  + + Y+++   I    E F ++ +
Sbjct: 918  PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974

Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
            +G +   +      R  +   + AT      L  +A V V ++++ D   ++ N
Sbjct: 975  SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025



 Score =  285 bits (730), Expect = 2e-76
 Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)

Query: 39   PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95
            PP+    + E    GT +     I   +G AG  + T++       + +  +DPV   + 
Sbjct: 183  PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241

Query: 96   LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154
              +T   LDR+    ++  +  Q   + ++        + I+V D ND+ P F+ + Y  
Sbjct: 242  --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296

Query: 155  TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213
            ++ E   VG  + T       ATD D  PN  I Y +++ +   P  ++ FEI    +G 
Sbjct: 297  SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348

Query: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
            I  R  ++ E+   Y + ++A+D+ ++    R+TT  + + V D +D  P F     V  
Sbjct: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407

Query: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
             R                 E++ P      + A D+D+          + YSI+ G    
Sbjct: 408  VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445

Query: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392
                F++  +T  L ++ P++ +  +++ L ++A+     PL   +GL  +++LD N+ +
Sbjct: 446  Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502

Query: 393  PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452
            P F    +Q  +LES P+G  +         L + A+D D  D    E  L    +   F
Sbjct: 503  PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553

Query: 453  TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507
            T+     T ++++   +DREE   Y+F + A D      P +     V++ V+D NDN P
Sbjct: 554  TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608

Query: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564
            TF +  Y V +  D   G SV+ ++AVD D  ++  ITY+I  G  +  F I   +  GL
Sbjct: 609  TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666

Query: 565  ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624
            +++A  ++  + R Y L V A+D       R     + + V   N   P  F    Y++ 
Sbjct: 667  VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720

Query: 625  ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681
            ++E    G  ++ + ATD    E   ITY +E+  PQ  F +   TG +T    LD E  
Sbjct: 721  VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778

Query: 682  DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736
              Y L ITA D G P  + T  + I+V DVNDNAP F  D Y       V E+   F  V
Sbjct: 779  VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834

Query: 737  GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
             Q+ ATD D+G+NG+V Y+      G+ + +   TS G + T  +L+RE    Y L   A
Sbjct: 835  LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893

Query: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
             D  + P  + + + + VLD++DN PVF    + V VEEN P G  + ++ A D D G N
Sbjct: 894  VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953

Query: 852  --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
              + Y+I    +   F L  F+GEL+ L  LDYE  P+             I  T  P +
Sbjct: 954  AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004

Query: 910  ATVTVIVK--DMNDYPPV 925
            +  TV V+  D ND PPV
Sbjct: 1005 SRATVHVRLLDRNDNPPV 1022



 Score =  283 bits (724), Expect = 1e-75
 Identities = 266/894 (29%), Positives = 401/894 (44%), Gaps = 81/894 (9%)

Query: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 336
            +P +YQA +PE       N    TP    +   R I P     G L Y++         +
Sbjct: 182  QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230

Query: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 395
            FF + P T  ++  E ++R+        + A QD+G P   A A L I + D N+  P F
Sbjct: 231  FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289

Query: 396  TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---VF 452
                Y+  + E+  VG  +         L + A D D     +    L      S   VF
Sbjct: 290  EQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340

Query: 453  TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTP 507
             +  ++G+ R      PVDREE ++Y  ++ A D  ++  P      V + V D NDN P
Sbjct: 341  EIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP 397

Query: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 566
             F E  Y V V  D+ PG  V+++TA D D+GSN  + Y I+ G A+G F ++  TG + 
Sbjct: 398  QFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALD 457

Query: 567  IAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 625
            +   ++    + Y L V+A D   PP    + + TV +  +   N + P F    +   +
Sbjct: 458  VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQATV 514

Query: 626  SEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 682
             E++ +G ++L++QA D + GD+  + Y +        F ++  TG +++   LDRE  D
Sbjct: 515  LESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD 574

Query: 683  RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQV 739
             Y   + A D G P  T++A+V++ V DVNDN P F    P     + E+A     V  V
Sbjct: 575  FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVTV 632

Query: 740  KATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGAV 796
             A D DA        + GN  N F ITS    G +  A+ L+ ++   Y L V A+DG  
Sbjct: 633  SAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT- 691

Query: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI 856
              R  T  + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N     
Sbjct: 692  --RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749

Query: 857  RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 916
               +    F +   TG ++    LDYE     + S T  + A D           + ++V
Sbjct: 750  FMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEILV 805

Query: 917  KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFP 973
             D+ND  P F +  Y+G V  D    T +  + A D D  GL   RV Y     DD    
Sbjct: 806  NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD-- 861

Query: 974  YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 1033
                 F VE  SG V T   L+ E    + L   A D G P   +   V + VL   + P
Sbjct: 862  ---GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918

Query: 1034 RFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVI 1089
               +++     V E +  G  V  ++A       N  I+Y IV GN  + F ++  +G +
Sbjct: 919  PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978

Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                 LDYE R  YVL +QA S  +V          + A V++ + D N++PPV
Sbjct: 979  TALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022



 Score =  231 bits (588), Expect = 6e-60
 Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V + V D NDN+P F  + Y   V E    G  +         A+D D G N  + Y I 
Sbjct: 385  VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                   +   F +    TG + +   L+YE    Y + ++A D  +        +  +T
Sbjct: 440  SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            V VLD +D  P+F+         +  PL Y                 +   +QAID D  
Sbjct: 493  VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
                 D   + Y  L G   D+P  F ++  T  +S+   ++R+    +   ++A +D+G
Sbjct: 536  -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586

Query: 373  HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
             P L A A + + +LD N+ +P FT P Y   + E A VG         TS + + A+D+
Sbjct: 587  TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637

Query: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
            D          +   +  + F++T       ++L  P+D + ++ Y  ++TA DG ++  
Sbjct: 638  DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695

Query: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551
              IV + V DAN + P F    Y V V  D   G +V+ ++A D D G N  ITY  +  
Sbjct: 696  AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753

Query: 552  AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610
            +   F I+  TG +T    ++     +Y L + A DN  P +      T Y+E+L  + N
Sbjct: 754  SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809

Query: 611  QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666
             + P+F +  Y   + E +     +L + ATDR+      + Y  + GD     F +  T
Sbjct: 810  DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869

Query: 667  TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725
            +GI+   + LDRE+  +Y+L   A D G P   +   V + V DVNDN PVF+       
Sbjct: 870  SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926

Query: 726  SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779
             V  EE +     V +V ATDPD G N Q+ Y +  GN   +F++   +G +   V L+ 
Sbjct: 927  DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986

Query: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834
            E R  Y LV+ AT     P  S  T+ +++LD +DN PV  N     + Y      + P 
Sbjct: 987  EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043

Query: 835  GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
            G  I ++ A D D+  +++Y            L+  TGEL L R+LD
Sbjct: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089



 Score =  140 bits (354), Expect = 8e-33
 Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V + V D NDN+PTF    Y   +NE   VGT++ T  + D  A             VI 
Sbjct: 596  VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644

Query: 193  YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
            Y      + + F I     G +V L   L+Y+ + +Y + + A+D        R  T  +
Sbjct: 645  YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             V+V D +   P+F       N  + RP      +                 I A D+D 
Sbjct: 699  VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                  +   I Y +    P+     F +   T  ++    ++ +    + L I A +DN
Sbjct: 742  G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790

Query: 372  GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
            G P  +    L I + D N+ +P F   SYQG + E  P           TS L+I A D
Sbjct: 791  GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841

Query: 431  KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486
            +D         + F   +D    F V  T GI R L  L   DRE    Y     A D G
Sbjct: 842  RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897

Query: 487  VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
            +  +  P+ V + V+D NDN P F +  +DV+V  +   G +V ++TA D DEG+N +I 
Sbjct: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957

Query: 546  YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            Y+I+ G   + F ++  +G +T    ++      Y L +QA  +AP   R     TV++ 
Sbjct: 958  YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012

Query: 605  VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660
            +L  N+  P    F  L  +   + +    G  +  + A D +  DS+TY+ E G+   +
Sbjct: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072

Query: 661  FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709
              L+ +TG L L +ALD       I+ +  SDG    T+   + + ++TD
Sbjct: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            ++ + V D N + P F+   Y   VNE  P GTT+         ATD D G N +I Y +
Sbjct: 697  QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
            +       S   F I    TG +  +  L+YED+  Y + I A D   N   +++ TT L
Sbjct: 752  E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             + V D +D  P FL        RD    +YQ ++      E++ P      I A D+D 
Sbjct: 802  EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
             +        + Y+   G  +D    F +   +  +  L  ++R+   ++ L   A    
Sbjct: 845  GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897

Query: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
              P      + + +LD N+  P F    +  ++ E++P+G  ++         R+ A D 
Sbjct: 898  MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948

Query: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
            D          +   +   VF +     +  LT L  +D E++  Y   I A      S 
Sbjct: 949  DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006

Query: 492  PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547
               V+++++D NDN P     EI ++ YV   +   PG ++ ++ A D D   +  +TY 
Sbjct: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063

Query: 548  ILVGAQGDFI-INKTTGLITIAPGVE 572
               G +   + +N +TG + ++  ++
Sbjct: 1064 FERGNELSLVLLNASTGELKLSRALD 1089


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  291 bits (746), Expect = 3e-78
 Identities = 301/1092 (27%), Positives = 473/1092 (43%), Gaps = 134/1092 (12%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            + V D ND +PTF+ + Y   + E  P GT++ T       ATD D G NGQ+ Y     
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLT-----LRATDPDVGANGQVTY----- 1686

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                 S+++F +    TG +   + L+ E++    + + A DR    +  + T  T+ V 
Sbjct: 1687 --GGVSSESFSLDPD-TGVLTTLRALDREEQEEINLTVYAQDRG---SPPQLTHVTVRVA 1740

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            V D +D  P F    L               +PE + P+ L  +  + P    D   N Q
Sbjct: 1741 VEDENDHAPTFGSAHL------------SLEVPEGQDPQTLTMLRASDP----DVGANGQ 1784

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
                   + Y IL G P      F +   + E   + P++R+    F L I+A +D G P
Sbjct: 1785 -------LQYRILDGDPSGA---FVLDLASGEFGTMRPLDREVEPAFQLRIEA-RDGGQP 1833

Query: 375  -LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
             L A   L + +LD N+ +P F +P+Y   + E  P G  +         L++ A D D 
Sbjct: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLL---------LQLQAHDPDA 1884

Query: 434  EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE---S 490
                    +L      +      +G  R    L   DRE+  +YTFS++A DG      S
Sbjct: 1885 GANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL---DREQCPSYTFSVSAVDGAAAGPLS 1941

Query: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS-------VIQLTAVDADEGSNGE 543
              V V I V D ND+ PTFP     + +    RPG S       +  L A D D G+N  
Sbjct: 1942 TTVSVTITVRDVNDHAPTFPTSPLRLRL---PRPGPSFSTPTLALATLRAEDRDAGANAS 1998

Query: 544  ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
            I Y +         ++  TG I +A     +  R   L + A D   PA    S   V I
Sbjct: 1999 ILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPAR---SATGVII 2055

Query: 604  EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS--ITYAIENGDPQRVF 661
              L    +  PRFP+      I E    G  +++ +A    G +  ITY+I +G+ +  F
Sbjct: 2056 VGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTF 2115

Query: 662  NLSETTGILTLGKA--LDRESTDRYILIITASDGRPDGTSTATV-NIVVTDVNDNAPVFD 718
            ++  +TG +T+  A  LD E + R  L++ A  G   G    TV  + + D NDNAP F 
Sbjct: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG---GAFAFTVLTLTLQDANDNAPRF- 2171

Query: 719  PYLPRNLSVVEEEANAFVG---QVKATDPDAGINGQVHYSLGNFN---NLFRIT-SNGSI 771
              L  +      E+    G   QV+A D D G  GQ+ YSL        LF +  + G+I
Sbjct: 2172 --LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229

Query: 772  YTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 831
             T   L+RE+     LV++ATD        + TL + V+D +DN P      + + V E+
Sbjct: 2230 TTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSED 2288

Query: 832  LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 891
               G+ I Q+   DVD G  + Y +     +  F++  + G +SL   LD+E     +  
Sbjct: 2289 ALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQ 2348

Query: 892  ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
            +         +     G A +TV+V+D+ND  P FS+ +Y+ M+      G+ I +V A 
Sbjct: 2349 LL-------AHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSAT 2401

Query: 952  DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN---LNEEPTTIFKLVVVA 1008
            D D        + Y +       PA  F V+ ++G + T V    L  + +    +V+ A
Sbjct: 2402 DRDSGA--NGHISYHLAS-----PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEA 2454

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA----I 1063
             D G P  ++ ATV + +    +  P FT   YR     +L    T++ + +  A     
Sbjct: 2455 RDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRS 2514

Query: 1064 NQSIVYSIVSGNEEDTFGIN--------------NITGVIYVNGPLDYETRTSYVLRVQA 1109
            + ++ YSI+SGN    F +                  G + +  PLD+E+ T Y L V A
Sbjct: 2515 HAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA 2574

Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
                   A+   P +S+   V + + D N++PPVF +  Y   V ED  +   +L V+A+
Sbjct: 2575 -------ADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627

Query: 1170 DKDTGNYSVMAY 1181
            D D G + ++ +
Sbjct: 2628 DADPGPHGLVRF 2639



 Score =  267 bits (683), Expect = 6e-71
 Identities = 287/1134 (25%), Positives = 472/1134 (41%), Gaps = 129/1134 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
            V++ V+D N+++P F  +     + E    G  ++T  + D        GPN  + Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP----GPNSDVRYRLL 1477

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
            +  P  P            TG +   + L+ E      ++++A DR  N + RR    + 
Sbjct: 1478 RQEPPVPALRLDAR-----TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSA 1532

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             V V D +D  P+F                  A+   +R PE+  P      + A D D 
Sbjct: 1533 RVFVTDENDNAPVF------------------ASPSRVRLPEDQPPGPAALHVVARDPDL 1574

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                  +   + Y +  G        F +H  T  LS++ P++R+   +  L + A    
Sbjct: 1575 -----GEAARVSYRLASGG----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625

Query: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
              P  A   L + + D N+++P F    Y   + E+ P G         TS L + A D 
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG---------TSLLTLRATDP 1676

Query: 432  DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQE 489
            D+            ++  S+     TG+   LT L+ +DREEQ+    ++ A D     +
Sbjct: 1677 DVGANGQVTYGGVSSESFSL--DPDTGV---LTTLRALDREEQEEINLTVYAQDRGSPPQ 1731

Query: 490  SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
               V V + V D ND+ PTF      + V     P  ++  L A D D G+NG++ Y IL
Sbjct: 1732 LTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL 1790

Query: 550  VG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
             G   G F+++  +G       ++  V   + L ++A D   PA     + TV   VL  
Sbjct: 1791 DGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTV--TVLDA 1848

Query: 609  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSE 665
            N+ + P FP   YS+E+ E +  G +LL LQA D +  +   +TY +  G     F L  
Sbjct: 1849 NDHA-PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG-TAGAFLLEP 1906

Query: 666  TTGILTLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDVNDNAPVFDPYLPR 723
            ++G L    ALDRE    Y   ++A DG   G  ++T +V I V DVND+AP F P  P 
Sbjct: 1907 SSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF-PTSPL 1965

Query: 724  NLSVVE-----EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--GSIYTA-- 774
             L +             +  ++A D DAG N  + Y L           +  G I  A  
Sbjct: 1966 RLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARS 2025

Query: 775  -VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
             V L    R    L +VATD     R +T  + + +    +  P F  ++    + EN P
Sbjct: 2026 PVALGPRDR---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAP 2082

Query: 834  AGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL--LRSLDYEAFPDQE 889
             GT I+   A     G N  ++Y I S   K  F++ P TG +++     LD+E  P   
Sbjct: 2083 PGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSP--R 2139

Query: 890  ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
              +    E+   +         +T+ ++D ND  P F +  Y   +        P+  V 
Sbjct: 2140 LRLVLQAESGGAF-----AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVE 2194

Query: 950  AEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
            A+D D       ++ Y +   Q   PA  +F V+  +G + T   L+ E     +LV++A
Sbjct: 2195 ADDLDQGS--GGQISYSLAASQ---PARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249

Query: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
             D G P +  SAT+ ++V+   +  R T  +     VSE A  G+ +  ++   ++   V
Sbjct: 2250 TDRGSPALVGSATLTVMVIDTND-NRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPV 2308

Query: 1069 --YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
              Y +     +D F +    G + + GPLD+E    Y L++ A                 
Sbjct: 2309 LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----------GPHEG 2358

Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
             A + + ++D N++ P F +  Y   + E     +++L V ATD+D+G    ++Y L  P
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418

Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
                  +GF V+   G +               F ++ T   G   SG  DV++
Sbjct: 2419 -----ADGFSVDPNNGTL---------------FTIVGTVALGHDGSGAVDVVL 2452



 Score =  255 bits (652), Expect = 2e-67
 Identities = 299/1091 (27%), Positives = 460/1091 (42%), Gaps = 123/1091 (11%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            + V D ND++P F   +Y   V E  P GT +         A D D G NG + Y +   
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL-----QLQAHDPDAGANGHVTYYLGAG 1897

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                T+      P   +G +     L+ E    Y   + A D A       +TT ++T+ 
Sbjct: 1898 ----TAGAFLLEPS--SGELRTAAALDREQCPSYTFSVSAVDGAAA--GPLSTTVSVTIT 1949

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            V D +D  P F             PL  +   P    P    P +    ++A D+D    
Sbjct: 1950 VRDVNDHAPTF----------PTSPLRLRLPRPG---PSFSTPTLALATLRAEDRDAGAN 1996

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGH 373
                   ILY  L GTP   P    +   T E+ +   PV      +   ++    D G 
Sbjct: 1997 A-----SILYR-LAGTP---PPGTTVDSYTGEIRVARSPVALGPRDRVLFIVAT--DLGR 2045

Query: 374  PLPAFAGLHIEILD-ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
            P  +  G+ I  L  E  + P F   S +  I E+AP G  I       SP  + A    
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI------VSPRAVHA---- 2095

Query: 433  IEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
               T  P  +  L+ +    F++  +     +   + +D E        + A  G   + 
Sbjct: 2096 -GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAF 2154

Query: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551
             V+  + + DANDN P F    Y  ++         ++Q+ A D D+GS G+I+Y +   
Sbjct: 2155 TVLT-LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAAS 2213

Query: 552  --AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
              A+G F ++ TTG IT    ++  +     L + A D   PA   ++  TV +      
Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI---DT 2270

Query: 610  NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTG 668
            N + P  PQ  + L +SE   +G+ +  +   D + G  + Y +    PQ  F++    G
Sbjct: 2271 NDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG 2329

Query: 669  ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 728
             ++L   LD E  DRY L + A DG  +G +  TV  +V DVNDNAP F   L + + + 
Sbjct: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV--LVEDVNDNAPAFSQSLYQVMLLE 2387

Query: 729  EEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT---AVKLNREVRDY 784
                 + +  V ATD D+G NG + Y L +  + F +  +NG+++T    V L  +    
Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447

Query: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
             ++V+ A D     R +  T+ +++ D +D++P FT S Y V V E+LP G+T+L +EA 
Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507

Query: 845  DVDLG---ANVSYRIRSPEVKHFFALHPFTGE--------------LSLLRSLDYEAFPD 887
            D D     A V Y I S      F L P   E              L LL  LD+E+   
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567

Query: 888  QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
               ++     A D        +  VTV V D+ND PPVF++  Y+  V  D   G  +  
Sbjct: 2568 YNLTVA----AADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623

Query: 948  VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
            V A DADP   P   VR+ V       P+ +FE++E SG +     L+ E     +LVV 
Sbjct: 2624 VEASDADPG--PHGLVRFTVSSGD---PSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678

Query: 1008 AFDD-GEPVMSSSATVKILVLH------PGEIPRFTQEEYRPPPVSELATKGTMVGVISA 1060
            A D  G     +  T+++  ++      P  +   +  E +PP        GT+V  + A
Sbjct: 2679 AADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP--------GTLVTTLHA 2730

Query: 1061 ----AAINQSIVYSIVSGNE----EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1112
                A     + YS++         + F +N+ TG +    P DYE   S+ L V A   
Sbjct: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790

Query: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
                 NL   S S T  V +  +DE  + PVF    +   V E AR   S+  V+ATD+D
Sbjct: 2791 ----GNL---SASVTVSVLVTGEDE--YDPVFLAPAFHFQVPEGARRGHSLGHVQATDED 2841

Query: 1173 TGNYSVMAYRL 1183
             G   ++ Y L
Sbjct: 2842 GGADGLVLYSL 2852



 Score =  254 bits (649), Expect = 5e-67
 Identities = 314/1199 (26%), Positives = 497/1199 (41%), Gaps = 141/1199 (11%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
            +T R LDR+    I+  V            + +  VR+ V D ND++PTF        V 
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761

Query: 158  E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
            E   P   T+         A+D D G NGQ++Y I     D   +  F + L  +G    
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL----DGDPSGAFVLDLA-SGEFGT 1809

Query: 217  RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF-LPCVLVPNTR 275
             + L+ E +  + + I+A D  Q      + T  LTV VLD +D  P F +P   V    
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ---PALSATLLLTVTVLDANDHAPAFPVPAYSV---- 1862

Query: 276  DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
                            PE++    +   +QA D D           + Y +  GT     
Sbjct: 1863 --------------EVPEDVPAGTLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA-- 1901

Query: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPY 394
              F + P + EL     ++R+    +   + A +     PL     + I + D N+ +P 
Sbjct: 1902 --FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959

Query: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD--------PELHLFLN 446
            F     +  +    P  +T + +L   + LR  A D+D              P     ++
Sbjct: 1960 FPTSPLRLRLPRPGPSFSTPTLAL---ATLR--AEDRDAGANASILYRLAGTPPPGTTVD 2014

Query: 447  DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
             YT    V ++ +      L P DR          T       S   ++ + +    +  
Sbjct: 2015 SYTGEIRVARSPVA-----LGPRDR----VLFIVATDLGRPARSATGVIIVGLQGEAERG 2065

Query: 507  PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLI 565
            P FP  S +  +  +  PG  ++   AV A  G+NG ITY IL G + G F I  +TG I
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAI 2124

Query: 566  TI--APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
            T+  A G++  V     L +QA      A       TV    L   N + PRF +  Y  
Sbjct: 2125 TVRSAEGLDFEVSPRLRLVLQAESGGAFA------FTVLTLTLQDANDNAPRFLRPHYVA 2178

Query: 624  EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQR-VFNLSETTGILTLGKALDRE 679
             + E+  +   LL ++A D +   G  I+Y++    P R +F++  TTG +T    LDRE
Sbjct: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE 2238

Query: 680  STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVG 737
                  L++ A+D G P    +AT+ ++V D NDN P      P  L V E+    + + 
Sbjct: 2239 IWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ--PWELRVSEDALLGSEIA 2296

Query: 738  QVKATDPDAG---------INGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELV 788
            QV   D D+G            Q  +S+G +     +T          L+ E  D Y+L 
Sbjct: 2297 QVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG--------PLDFEQCDRYQLQ 2348

Query: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
            ++A DG   P      L + V D++DN+P F+ S Y V++ E+ P G+ IL + A D D 
Sbjct: 2349 LLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405

Query: 849  GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
            GAN  +SY + SP     F++ P  G L  +         D   ++  ++EA D      
Sbjct: 2406 GANGHISYHLASPA--DGFSVDPNNGTLFTIVGT-VALGHDGSGAVDVVLEARDHGAPGR 2462

Query: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
               ATV V ++D ND+ P F+   Y+  V  D   G+ + T+ A DAD     A+ V Y 
Sbjct: 2463 AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA-VDYS 2521

Query: 967  VDDVQ----FPYPASIFEVEEDSGR-------VITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
            +        F     + E  E +G        ++    L+ E  T + L V A D G+P 
Sbjct: 2522 IISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPP 2581

Query: 1016 MSSSATVKILVLHPGEIPR-FTQEEYRPPPVSELATKGTMVGVISAAAI---NQSIVYSI 1071
             SS   V + VL   + P  FT+  YR     +      ++ V ++ A    +  + +++
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641

Query: 1072 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN--TAK 1129
             SG+    F ++  +G + +   LD ET+  + L VQA            P+ ++   A 
Sbjct: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----------PAGAHFALAP 2691

Query: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI-IPPI 1188
            V IE+QD N+H P F        V+E+    T V  + A D D G +  + Y L+   P 
Sbjct: 2692 VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPG 2751

Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
             EG+E F + + TG ++  + F       F+  V A D      S    VLV+  ++ D
Sbjct: 2752 PEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD 2810



 Score =  250 bits (639), Expect = 7e-66
 Identities = 223/768 (29%), Positives = 350/768 (45%), Gaps = 48/768 (6%)

Query: 463  LTLLQPVDREEQQTYTFSITAFDGVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYT 520
            L +   +DRE +  Y   + A+DG         ++++ ++D ND+ P F +  Y   V  
Sbjct: 207  LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266

Query: 521  DMRPGDSVIQLTAVDADEGSNGEITYEI---LVGAQGDFIINKTTGLITIAPGVEMIVGR 577
             + PG  V+Q+ A DAD G NG +TYEI        G F I+  TGL+ +   ++    R
Sbjct: 267  SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326

Query: 578  TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS-PPRFPQLMYSLEISEAMRVGAVLL 636
             + L VQA D     E  ++  TV++     N  S    F     S ++SEA   G ++ 
Sbjct: 327  VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386

Query: 637  NLQATD-REGD--SITYAIENGDPQRVFNLSETTGILTL---GKALDRESTDRYILIITA 690
             +  +D  +GD   +  ++E G+    F LS    ++ L    + LDRE  D Y L +TA
Sbjct: 387  RISVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTA 444

Query: 691  SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGI 748
            +D G P   + A   + VTDVNDNAP FD  L R   + E     +FV +V A DPD G 
Sbjct: 445  TDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504

Query: 749  NGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 805
            NGQV YSL  G   + F I  ++G I TA  L+ E+    +L+VVATDG + P  S+ T+
Sbjct: 505  NGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564

Query: 806  AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRS---PE 860
            ++ + D++DN P F  + Y   + E    GT  LQ+ A D D G    +SY + +     
Sbjct: 565  SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624

Query: 861  VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
                F +   +G++   R+LD +  P   +S  F V A D  G     +  V V + D N
Sbjct: 625  GSPPFRIDAHSGDVCTTRTLDRDQGP---SSFDFTVTAVD--GGGLKSMVYVKVFLSDEN 679

Query: 921  DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 980
            D PP F  R Y   ++  +  GT +  + A D D       R+ Y +     P    +F 
Sbjct: 680  DNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS--HGRLSYHILAGNSP---PLFT 734

Query: 981  VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1040
            ++E SG +     L     ++ +L + A D G      SA V I ++     P   ++  
Sbjct: 735  LDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQ 794

Query: 1041 RPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1097
                V E    GT VG++ A         +  S+  G+    F ++ ++G++    PLD 
Sbjct: 795  YVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854

Query: 1098 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1157
            E     VL ++      V A   VP     A+V + + D N++ P F        +  + 
Sbjct: 855  EL-LGPVLELE------VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNT 907

Query: 1158 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
               T +  ++A D D+G  S + + L    +  G   F V+  TG ++
Sbjct: 908  APGTPIYTLRALDPDSGVNSRVTFTL----LAGGGGAFTVDPTTGHVR 951



 Score =  248 bits (633), Expect = 4e-65
 Identities = 312/1242 (25%), Positives = 505/1242 (40%), Gaps = 126/1242 (10%)

Query: 46   IDEESRNGTILVDNM--LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVL 103
            IDEE   GT++ D    L  GTA      I       V   + +D    ++    T RVL
Sbjct: 51   IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV---RTARVL 107

Query: 104  DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
            DR+         V         G  +  EV + V D ND++P F        V E T  G
Sbjct: 108  DREQRDRYRFTAVTPD------GATV--EVTVRVADINDHAPAFPQARAALQVPEHTAFG 159

Query: 164  TTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPTSNDTFEIPLMLTGNIVL 216
            T           A D D G  G   Y +        +  +     D   +P      +V+
Sbjct: 160  TRYPL-----EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP-----ELVV 209

Query: 217  RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
               L+ E+++ Y + ++A D     +  R     L V +LD +D  P F           
Sbjct: 210  TGELDRENRSHYMLQLEAYDGG---SPPRRAQALLDVTLLDINDHAPAF----------- 255

Query: 277  CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE-DYP 335
                 Y A + E   P   +P++    + A D D  +        + Y I     E D P
Sbjct: 256  -NQSRYHAVVSESLAPG--SPVL---QVFASDADAGVNG-----AVTYEINRRQSEGDGP 304

Query: 336  RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
              F +   T  L L  P++ +  +  +LV++A     HP    A + + + D N+  P  
Sbjct: 305  --FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM 362

Query: 396  TMPSYQG----YILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
            T+          + E+AP G  ++         RI   D D  D     +++ L      
Sbjct: 363  TVIFLSADGSPQVSEAAPPGQLVA---------RISVSDPD--DGDFAHVNVSLEGGEGH 411

Query: 452  FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMDANDNTP 507
            F + TQ  +   + + + +DREE+  Y   +TA D       +E   V + V D NDN P
Sbjct: 412  FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAP 470

Query: 508  TFPEISYDVYVYTDMR-PGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLI 565
             F    Y      ++  PG  V+++TA D D+G+NG++TY +  GA    F I+ T+G+I
Sbjct: 471  AFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGII 530

Query: 566  TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 625
            T A  ++  +     L V A D   P    ++  +V ++ +   N + P+F +  Y+  +
Sbjct: 531  TTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV---NDNEPQFQRTFYNASL 587

Query: 626  SEAMRVGAVLLNLQATDREGDS---ITYAI-----ENGDPQRVFNLSETTGILTLGKALD 677
             E  + G   L + ATD +      ++Y++      +G P   F +   +G +   + LD
Sbjct: 588  PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTTRTLD 645

Query: 678  RES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 736
            R+     +   +TA DG     S   V + ++D NDN P F P         +      V
Sbjct: 646  RDQGPSSFDFTVTAVDGG-GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAV 704

Query: 737  GQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYT-AVKLNREVRDYYELVVVATD 793
             +++A DPD G +G++ Y +  GN   LF +     + T A  L R      +L + A D
Sbjct: 705  LRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAED 764

Query: 794  GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG-ANV 852
            G       +  + I ++      P+F    Y   V E++  GT++  ++A +     A V
Sbjct: 765  GGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPV 824

Query: 853  SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF-PDQEASITFLVEAFDIYGTMPPG--I 909
            +  +   + +  F+L   +G L  LR LD E   P  E  +            +PP   +
Sbjct: 825  TLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVR-------AGSGVPPAFAV 877

Query: 910  ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
            A V V++ D+ND  P F       ++ P+   GTPI T+ A D D      S V  RV  
Sbjct: 878  ARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD------SGVNSRVTF 931

Query: 970  VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
                     F V+  +G V     L        +L + A D G P  +S   ++++V   
Sbjct: 932  TLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDV 991

Query: 1030 GE---IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS-IVYSIVSGNEEDTFGINNI 1085
            G     PRF    YR    S   T GT V  + A A +   I Y + +      FG+   
Sbjct: 992  GTRGLAPRFNSPTYRVDLPSG-TTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQ 1050

Query: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
            +G ++V   LD E +  Y+L+V A    V  +   +  ++ TA V + I ++N H P   
Sbjct: 1051 SGWLWVRAALDREAQELYILKVMA----VSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106

Query: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
            +      V+E+    TSV RV ATD+D+G    + Y L    + E  + F +   TG + 
Sbjct: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL--QQLSEDSKAFRIHPQTGEVT 1164

Query: 1206 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
            T       ++S ++  V   D      S    V V+V++  D
Sbjct: 1165 TLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLND 1206



 Score =  242 bits (617), Expect = 3e-63
 Identities = 295/1132 (26%), Positives = 486/1132 (42%), Gaps = 143/1132 (12%)

Query: 130  YHEVRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
            +  +R+VV+D      +P F   +Y   +   T  GT +         A   D GP    
Sbjct: 981  HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL-----QVQAQAPDGGP---- 1031

Query: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
               I Y+     ++  F +    +G + +R  L+ E +  Y + + A   ++    ++T 
Sbjct: 1032 ---ITYHLAAEGASSPFGLEPQ-SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTG 1087

Query: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
            T T+ V +L+ ++  P           R     T+      L   E   P      + A 
Sbjct: 1088 TATVRVSILNQNEHSP-----------RLSEDPTF------LAVAENQPPGTSVGRVFAT 1130

Query: 308  DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
            D+D     P+ R  + YS L    ED  + F +HP+T E++ L+ ++R+    + L+++ 
Sbjct: 1131 DRDSG---PNGR--LTYS-LQQLSED-SKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQV 1183

Query: 368  EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
            +     P      +H+ +LD N+ SP F   S       +A  G  I     +     + 
Sbjct: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQAS------GAAGGGLPIQVPDRVPPGTLVT 1237

Query: 428  ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY--------LTLLQPVDREEQQTYTF 479
             L       KDP+      + T ++T+T  G   +        L    P+ R E+  Y  
Sbjct: 1238 TLQ-----AKDPDEG---ENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289

Query: 480  SITAFDGVQESEPVIVNIQVM--------------DANDNTPTFP-EISYDVYVYTDMRP 524
            +++A D  Q S P   ++Q++              D  +  P  P  +   V     +RP
Sbjct: 1290 TLSAHD--QGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347

Query: 525  GDSVIQLTAVDADEGSNGEITYEILVGA--QGDFIINKTTGLITIAPGVEMIVGRTY-AL 581
            G  +  + A   +    G +TY ++ GA  +G F ++  +G + +A  ++   G  + AL
Sbjct: 1348 GSLLGSVAA--PEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRAL 1405

Query: 582  TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
            TV+A        R   +  V ++V    N+  P F +   +L + E    GA L   +A+
Sbjct: 1406 TVRAEGPGGAGAR---LLRVQVQV-QDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461

Query: 642  DREG----DSITYAIENGDPQ-RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
            D +G      + Y +   +P      L   TG L+  + LDRE+T   +L++ A+D RP 
Sbjct: 1462 DADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD-RPA 1520

Query: 697  GTST-----ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG-QVKATDPDAGING 750
              S       +  + VTD NDNAPVF    P  + + E++        V A DPD G   
Sbjct: 1521 NASRRRAARVSARVFVTDENDNAPVFAS--PSRVRLPEDQPPGPAALHVVARDPDLGEAA 1578

Query: 751  QVHYSLGNFNN-LFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
            +V Y L +  +  FR+ +S G++     L+RE R  + L VVA+D    PR +T  L + 
Sbjct: 1579 RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638

Query: 809  VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 866
            V D++D +P F    Y+VL+ EN P GT++L + A D D+GAN  V+Y   S E    F+
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFS 1695

Query: 867  LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPP 924
            L P TG L+ LR+LD E    ++  I   V A D     PP +   TV V V+D ND+ P
Sbjct: 1696 LDPDTGVLTTLRALDRE----EQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAP 1749

Query: 925  VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 984
             F    +  +  P+      +T + A D D       +++YR+ D     P+  F ++  
Sbjct: 1750 TFGS-AHLSLEVPEGQDPQTLTMLRASDPDVGA--NGQLQYRILDGD---PSGAFVLDLA 1803

Query: 985  SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPP 1043
            SG   T   L+ E    F+L + A D G+P +S++  + + VL   +  P F    Y   
Sbjct: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY-SV 1862

Query: 1044 PVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1099
             V E    GT++  + A    A  N  + Y + +G     F +   +G +     LD E 
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQ 1921

Query: 1100 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1159
              SY   V A      +        S T  V I ++D N+H P F        +      
Sbjct: 1922 CPSYTFSVSA------VDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPS 1975

Query: 1160 FT----SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1207
            F+    ++  ++A D+D G  + + YRL   P      G  V++YTG I+ A
Sbjct: 1976 FSTPTLALATLRAEDRDAGANASILYRLAGTP----PPGTTVDSYTGEIRVA 2023



 Score =  237 bits (604), Expect = 8e-62
 Identities = 257/1049 (24%), Positives = 439/1049 (41%), Gaps = 132/1049 (12%)

Query: 111  IHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
            +H +VVQ +    + ++G+     V + VRD NDN P+                 T IF 
Sbjct: 327  VHELVVQARDGGAHPELGSAF---VTVHVRDANDNQPSM----------------TVIF- 366

Query: 169  GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN--------------- 213
              S D      +  P GQ+  V + +  DP   D   + + L G                
Sbjct: 367  -LSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423

Query: 214  IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
            + + +RL+ E++  Y + + A D     +          + V D +D  P F        
Sbjct: 424  VCVARRLDREERDAYNLRVTATDSG---SPPLRAEAAFVLHVTDVNDNAPAF-------- 472

Query: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
                R L     +PE+  P      +V    +  DQ  N Q       + YS+  G    
Sbjct: 473  ---DRQLYRPEPLPEVALP---GSFVVRVTARDPDQGTNGQ-------VTYSLAPGA--- 516

Query: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
            +  +F + P +  ++    ++ +   +  L++ A      PL + A + + + D N+  P
Sbjct: 517  HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEP 576

Query: 394  YFTMPSYQGYILESAPVGA-----TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
             F    Y   + E    G      T +D+ +    L   +L   +  +  P   +  + +
Sbjct: 577  QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI--DAH 634

Query: 449  TSVFTVTQTGITRYLTLLQPVDREE-QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 507
            +     T+T           +DR++   ++ F++TA DG      V V + + D NDN P
Sbjct: 635  SGDVCTTRT-----------LDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683

Query: 508  TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT 566
             F    Y   +     PG +V++L A D D+GS+G ++Y IL G     F +++ +GL+T
Sbjct: 684  QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743

Query: 567  IAPGVEMIVGRTYALTVQAAD----NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 622
            +A  +         L + A D     A P+ R      V I ++ P   +PP F QL Y 
Sbjct: 744  VAWPLARRANSVVQLEIGAEDGGGLQAEPSAR------VDISIV-PGTPTPPIFEQLQYV 796

Query: 623  LEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
              + E +  G  +  +QA +  G    +T ++  GDP+ +F+L   +G+L   + LDRE 
Sbjct: 797  FSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDREL 856

Query: 681  TDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 739
                + L + A  G P   + A V +++ DVNDN+P F       L          +  +
Sbjct: 857  LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916

Query: 740  KATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVH 797
            +A DPD+G+N +V ++L  G         + G +     L       +EL + A DG   
Sbjct: 917  RALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976

Query: 798  PRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855
            PR S   L + V D+     +P F + TY V +     AGT +LQ++A+  D G  ++Y 
Sbjct: 977  PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYH 1035

Query: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGT-----MPPGIA 910
            + +      F L P +G L +  +L      D+EA   ++++   + G+        G A
Sbjct: 1036 LAAEGASSPFGLEPQSGWLWVRAAL------DREAQELYILKVMAVSGSKAELGQQTGTA 1089

Query: 911  TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 970
            TV V + + N++ P  S+      VA +   GT +  V+A D D    P  R+ Y +   
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQ-- 1145

Query: 971  QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 1030
            Q    +  F +   +G V T   L+ E  + ++L+V   D G P  S++ TV + VL   
Sbjct: 1146 QLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLN 1205

Query: 1031 E-IPRFTQEEYR-----PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1080
            +  P F Q         P  V +    GT+V  + A       N +I+Y++ +G   + F
Sbjct: 1206 DNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSELF 1264

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQA 1109
             ++  +G +    PL    R  YVL + A
Sbjct: 1265 SLHPHSGELLTAAPLIRAERPHYVLTLSA 1293



 Score =  227 bits (578), Expect = 8e-59
 Identities = 291/1105 (26%), Positives = 464/1105 (41%), Gaps = 145/1105 (13%)

Query: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
            PA  V + E+   GT+L+        AG            +V Y++        L   S+
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGA---------NGHVTYYLGAGTAGAFLLEPSS 1908

Query: 100  GRV-----LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
            G +     LDR+  P    S+          + T +   V I VRD ND++PTF      
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLR 1966

Query: 154  ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
              +    P  +T     +    A D D G N  I Y +   P   T+ D++      TG 
Sbjct: 1967 LRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLAGTPPPGTTVDSY------TGE 2019

Query: 214  I-VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD-DLGPMFLPCVLV 271
            I V R  +    + R   I+     A +L     + T + +  L G+ + GP F      
Sbjct: 2020 IRVARSPVALGPRDRVLFIV-----ATDLGRPARSATGVIIVGLQGEAERGPRF------ 2068

Query: 272  PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 331
            P          +A I E             PP   I   R +        I YSIL G  
Sbjct: 2069 PRASS------EATIREN-----------APPGTPIVSPRAVHAGGTNGPITYSILSGNE 2111

Query: 332  EDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 389
            +     F + P T  +++      DF    +  LV++AE        AF  L + + D N
Sbjct: 2112 KGT---FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDAN 2165

Query: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL---N 446
            + +P F  P Y  ++ ES P          L  PL  V  D D++     ++   L    
Sbjct: 2166 DNAPRFLRPHYVAFLPESRP----------LEGPLLQVEAD-DLDQGSGGQISYSLAASQ 2214

Query: 447  DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVN-----IQVMD 501
                +F V  T  T  +T    +DRE        + A D      P +V      + V+D
Sbjct: 2215 PARGLFHVDPT--TGTITTTAILDREIWAETRLVLMATD---RGSPALVGSATLTVMVID 2269

Query: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV--GAQGDFIIN 559
             NDN PT P+  +++ V  D   G  + Q+T  D D   +G + + +L   G Q  F + 
Sbjct: 2270 TNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVG 2325

Query: 560  KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 619
            +  G +++   ++      Y L + A D   P E R ++ TV +E +   N + P F Q 
Sbjct: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANL-TVLVEDV---NDNAPAFSQS 2379

Query: 620  MYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL--TLGK 674
            +Y + + E    G+ +L++ ATDR+  +   I+Y + +  P   F++    G L   +G 
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS--PADGFSVDPNNGTLFTIVGT 2437

Query: 675  -ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
             AL  + +    +++ A D G P   + ATV++ + D ND+AP F     R     +   
Sbjct: 2438 VALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPP 2497

Query: 733  NAFVGQVKATDPDAG-INGQVHYSL--GNFNNLFRITSN---------------GSIYTA 774
             + +  ++ATD D    +  V YS+  GN+  +F++                  G +   
Sbjct: 2498 GSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLL 2557

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
              L+ E    Y L V A D    P+ S + + + VLD++DN PVFT ++Y V V E+ P 
Sbjct: 2558 EPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPV 2617

Query: 835  GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
            G  +L +EA D D G +  V + + S +    F L   +G L L  +LD E     +A  
Sbjct: 2618 GAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET----QARH 2673

Query: 893  TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
              +V+A D  G     +A VT+ V+D+ND+ P F   +    VA +   GT +TT++A D
Sbjct: 2674 QLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAID 2732

Query: 953  ADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 1011
             D       R+RY + +    P     F +   +G +  RV  + E T  F+L+V A D 
Sbjct: 2733 GDAGAF--GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790

Query: 1012 GEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQS 1066
            G   +S+S TV +LV    E  P F    +    V E A +G  +G + A       +  
Sbjct: 2791 GN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-VPEGARRGHSLGHVQATDEDGGADGL 2847

Query: 1067 IVYSIVSGNEEDTFGINNITGVIYV 1091
            ++YS+ + +    FGIN  TG +Y+
Sbjct: 2848 VLYSLATSSPY--FGINQTTGALYL 2870



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 112/464 (24%), Positives = 189/464 (40%), Gaps = 79/464 (17%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 189
            V + ++D+ND++P+F    Y   V E  P G+T+ T       ATD D    +  ++Y  
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522

Query: 190  -------VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
                   V Q  P    + ++        G +VL + L++E  T+Y + + A DR Q   
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ--- 2579

Query: 243  ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
              +++   +TV VLD +D  P+F        TR     +Y+  +PE  TP     + V  
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVF--------TR----ASYRVTVPE-DTPVGAELLHV-- 2624

Query: 303  PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
              +A D D     P     + +++  G P      F +   +  L L   ++ +   +  
Sbjct: 2625 --EASDAD-----PGPHGLVRFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQ 2674

Query: 363  LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
            LV++A    G    A A + IE+ D N+  P F +      + E+ P G  ++       
Sbjct: 2675 LVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT------ 2727

Query: 423  PLRIVALDKD-----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 471
               + A+D D           +E    PE           F +  +  T  L    P D 
Sbjct: 2728 ---LHAIDGDAGAFGRLRYSLLEAGPGPEGR-------EAFALNSS--TGELRARVPFDY 2775

Query: 472  EEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 531
            E  +++   + A D    S  V V++ V   ++  P F   ++   V    R G S+  +
Sbjct: 2776 EHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHV 2835

Query: 532  TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI-----APG 570
             A D D G++G + Y  L  +   F IN+TTG + +     APG
Sbjct: 2836 QATDEDGGADGLVLYS-LATSSPYFGINQTTGALYLRVDSRAPG 2878



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 68/290 (23%), Positives = 106/290 (36%), Gaps = 45/290 (15%)

Query: 981  VEEDSGRVITRVNLNEEPTTIFKLVVVAFD--------------DGEPVMSSSATVKILV 1026
            ++E SG V T   L+ E    ++   V  D              D  P    +     + 
Sbjct: 94   IDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVP 153

Query: 1027 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
             H     R+  E  R      L T+G                Y++      +TF +    
Sbjct: 154  EHTAFGTRYPLEPARDADAGRLGTQG----------------YALSGDGAGETFRLETRP 197

Query: 1087 GV-------IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
            G        + V G LD E R+ Y+L+++A        +   P +   A + + + D N+
Sbjct: 198  GPDGTPVPELVVTGELDRENRSHYMLQLEA-------YDGGSPPRRAQALLDVTLLDIND 250

Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
            H P F +  Y   VSE     + VL+V A+D D G    + Y  I     EG   F ++ 
Sbjct: 251  HAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE-INRRQSEGDGPFSIDA 309

Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1249
            +TGL++        +R   +  V A D       G A V V V +  D Q
Sbjct: 310  HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQ 359



 Score = 31.6 bits (70), Expect = 6.8
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 18/91 (19%)

Query: 1375 GALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAA 1434
            GA+ A   ++++  + A+++ LV  R    R+AE       QAA P A  ++        
Sbjct: 2939 GAVAASLGVVVVLALAALVLGLVRARS---RKAEAAPGPMSQAA-PLASDSLQKLGR--- 2991

Query: 1435 PPPPPPPPPGAHLYEELGDSSMHKYEMPQYG 1465
               PP PPP  HLY +          +P YG
Sbjct: 2992 --EPPSPPPSEHLYHQ---------TLPSYG 3011


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  290 bits (743), Expect = 6e-78
 Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)

Query: 128  IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
            +I  +V I V D NDN+PTF ++ Y   + E TPVGT IF        ATD D G  G +
Sbjct: 113  VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167

Query: 188  EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
             Y  Q        +  F I     G + + + L+YE    Y + + A D  Q+     +T
Sbjct: 168  LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218

Query: 248  TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
               L + + D  D+ P+F+             L Y   I E   P     II      AI
Sbjct: 219  LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261

Query: 308  DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
            DQD+       RP GI Y+I+ G         ++        LL+  N  +   F L +K
Sbjct: 262  DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315

Query: 367  AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
              + N    P+ A +    +I ++D N+ +P F    Y   I E A VG  +        
Sbjct: 316  GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367

Query: 423  PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
            PL I  +DKD     +    ++L  + +  F ++ T +       + +  P+D E    Y
Sbjct: 368  PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427

Query: 478  TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
             F + A + V +      V I +++ NDN P F +  Y++ +Y ++  G SV+ + A D 
Sbjct: 428  DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487

Query: 537  DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
            D G+ GE++Y         F ++K TGLI +   ++  + + + LT+ A D         
Sbjct: 488  DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542

Query: 597  SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
            +   V I VL  N+ + P F +  Y   + E       L+ L+ATD +    + ITY+I 
Sbjct: 543  TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601

Query: 654  NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
            +      +   +L E  G++++ + LD E       Y+ ++    G P   ST  V I V
Sbjct: 602  SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661

Query: 708  TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
             D NDN P F    Y    +SVVE   A A V  + ATD D     GQ  + YSL   + 
Sbjct: 662  FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717

Query: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
             FRI + +G I T   L+RE +  Y L+V A DG V     T   T+ I +LDI+DN P 
Sbjct: 718  QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777

Query: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
            + ++ Y + + E  P  + +  + A D DLG N  + Y I+ P    F++L+  TG++  
Sbjct: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835

Query: 877  LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
              + LD E     EA +   +         PP      ATV V + D+ND  P F    +
Sbjct: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895

Query: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
               V      G  I  V A D D  GL    V YR   +    P   F +   SG V+T 
Sbjct: 896  VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950

Query: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
              L+ E    ++L VVA D G P  SS++T+ I VL    E P F    Y      ++  
Sbjct: 951  TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010

Query: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
            +  +V +    +   +N  + Y I  GN +  F +     V+     LD ET  +Y+L +
Sbjct: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070

Query: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
            +A      + N  V  + + TA V++ + D N++ P+F +  Y   V ED     S+L++
Sbjct: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124

Query: 1167 KATDKDTGNYSVMAYRLI 1184
            KATD D G +  + YR++
Sbjct: 1125 KATDADEGEFGRVWYRIL 1142



 Score =  284 bits (727), Expect = 4e-76
 Identities = 345/1337 (25%), Positives = 584/1337 (43%), Gaps = 155/1337 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V I V D NDN P   +     T++E +PV +     F     A+D D G N ++ + I 
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                   + +        TG + + + L+ E    Y + I   D  +N    R     L 
Sbjct: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            + + D +D  P+F               TYQA + E  +P      ++  PI A+D D++
Sbjct: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993

Query: 313  IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF-----DLVIKA 367
            I        ++   L+G        F ++  T  +++   V  D  + F     +L++ A
Sbjct: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIID-REAFSPPILELLLLA 2043

Query: 368  EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
            E D G  L + A L I ILD+N+  P F+  +   ++LE+ P G ++         L++ 
Sbjct: 2044 E-DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVT 2092

Query: 428  ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 486
            A D+D     +    +             TG+ R       +DREEQ++Y  ++ A D  
Sbjct: 2093 ATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRG 2150

Query: 487  -VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
             V  S   IV I + D ND+ P F      V V     PG  +  +TA+D D   N ++ 
Sbjct: 2151 TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLE 2208

Query: 546  YEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA- 592
            Y I           LV  Q D F +N  TG + +   +   +  TY +T+   DNA    
Sbjct: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268

Query: 593  ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---G 645
            ER  S+    + + VL  N+ +P   P  + Y +E I E    G  L+ + A D +    
Sbjct: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328

Query: 646  DSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
              +TY + +  P     L +++ G +   + +D E        + ASD G P   +   V
Sbjct: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388

Query: 704  NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
             + + D+NDN P+FD    +     +      +  V ATD D+G    + YSLG+  + F
Sbjct: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF 2448

Query: 764  RIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPV 818
             I  + G IY    L+RE +D+Y L  +A D     A + R +++ + I+VLD++D  P 
Sbjct: 2449 AINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508

Query: 819  FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
            F+   ++  V EN PAGT+++ + A D D G N  ++Y +  P V+ F  +   +G ++ 
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTT 2567

Query: 877  LRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKG 933
             R L  YE F       +  V A D  G  PP  G   + V V D+ND  PVF +     
Sbjct: 2568 QRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGT 2618

Query: 934  M--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
            +  +  +    + +  VYA D D  GL  + VRY             F ++  SG + T 
Sbjct: 2619 ILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676

Query: 992  VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPP 1044
              L+ E   ++ L++VA D G+PV   +     + L       P F +      +Y+   
Sbjct: 2677 QRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT 2736

Query: 1045 VSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1099
            V E + +GT+VG ++ A       N  + Y I +GNEE  F +    G + V   LD E 
Sbjct: 2737 VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRER 2795

Query: 1100 RTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1153
               +   V+A S             L + +     +V + ++D N+ PP F K  Y  GV
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855

Query: 1154 SEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIK 1205
            + DA++ + +++V A D D GN     YS++A   +R +    ++  + F + +  G+++
Sbjct: 2856 ATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILR 2915

Query: 1206 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEK 1262
            T  LF      YF   ++A D     L+G  D  +  +  L  D +V IV N  P  V  
Sbjct: 2916 TFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRG 2970

Query: 1263 KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1322
              E+   +L       I GA  +V +   + H D     ++ + +L ++ ++  TNR +D
Sbjct: 2971 FEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILD 3023

Query: 1323 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAF 1382
             + + + +D     +   F+ Y      +L+++   +V    +  + +   + A++ LA 
Sbjct: 3024 VDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAI 3074

Query: 1383 IIILCCIPAILVVLVSY 1399
            ++ L    A+L VL+++
Sbjct: 3075 LLFLA---AMLFVLMNW 3088



 Score =  280 bits (716), Expect = 8e-75
 Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)

Query: 39   PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
            PP T    I AID++             KG   G   TI   +  N +    +D +  +L
Sbjct: 250  PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293

Query: 95   FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
             LN    +LDR+ P+  H  ++ V+              +     I+V D NDN+P F  
Sbjct: 294  TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350

Query: 150  ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
              Y   + EL  VG  +           D D+  G N   E  +  N     S+     P
Sbjct: 351  SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402

Query: 208  LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
              + G   +R R    L+YE   RY   + AN+   +          + + +++ +D  P
Sbjct: 403  TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458

Query: 264  MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
            +F            +PL Y  ++ E       N  + T  +  +  D +     +   + 
Sbjct: 459  IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496

Query: 324  YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
            Y        D P  F +   T  + L+  ++ +  Q+F L I A    G        + I
Sbjct: 497  YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549

Query: 384  EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
             +LD N+  P F   +Y G + E+ P         ++T  +R+ A D+D          +
Sbjct: 550  NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600

Query: 444  F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
               + + S F ++       +++ +P+D E+       +T       + P    V V I+
Sbjct: 601  VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660

Query: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
            V D NDN PTF + +Y V V  ++  G +V+ L A D D   E     I Y +    Q  
Sbjct: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718

Query: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
            F IN  +G IT    ++      Y L V+A D      ++  I TV I +L  N+  P  
Sbjct: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777

Query: 616  FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
            +    Y + + E     + +  + A D    E  ++ Y+I+   P + ++L+ TTG I T
Sbjct: 778  WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835

Query: 672  LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
                LDRE+ D       R I++     GRP    TS+ATV + + D+NDN P F   LP
Sbjct: 836  THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894

Query: 723  RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
                V+E   A   + QV A D D G+NG V Y +  G     F I +S+G + T  +L+
Sbjct: 895  FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954

Query: 779  REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
            RE    Y+L VVA+D     + ST TL I VLD++D +P F  + Y V V E++P    +
Sbjct: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014

Query: 839  LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
            + +   D D+G N  +SY I    V   F++      +  +  LD E      A+   ++
Sbjct: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070

Query: 897  EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
            EA D    G    G ATV V V D+ND  P+F +  Y+  V  D  +G  I  + A DAD
Sbjct: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130

Query: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
                   RV YR   +      + F +   +G ++     L+ E  +   L+V A++   
Sbjct: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185

Query: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
              M SS  V + V     E P FTQ++Y    + E A  GT V V+ A   +      + 
Sbjct: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245

Query: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
            Y I+SG  E  F I+  TG+I     LDYET+TSY++ V A        +   P      
Sbjct: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297

Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
             VYI + +E +    F    Y   + E+  + T ++RV+A   D  N + + YR      
Sbjct: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355

Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
             + K  F ++  TG+I    L    +  ++   V+A DD G  +     V ++V+++ D
Sbjct: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413



 Score =  275 bits (703), Expect = 3e-73
 Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
            +V I V D NDNSP F   S  A ++ E  PVG  + T       A D D G NGQ+ + 
Sbjct: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457

Query: 191  IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
            +         +  T+ND+        G + + + L+ E+   Y + + A+DR       R
Sbjct: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507

Query: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
                 L V +LD +D  P+              P  Y  ++ E      +        ++
Sbjct: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551

Query: 306  AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
            A D+D  I        + Y I  G  +     F M   + E++    P +R+    + LV
Sbjct: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603

Query: 365  IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
               E +    L A   +++ I+DEN+ +P F  P Y+  +L+  P      D+LN TS +
Sbjct: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655

Query: 425  RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
             I ALD D          +   +  + F + +  G+   +T  + +D E     YT  +T
Sbjct: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712

Query: 483  AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
            A D        +  +  V+VN+   D NDN PTFP      +  T+ +PG  V    A D
Sbjct: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770

Query: 536  ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
             D G NG++ Y I+ G   G+F+I+   G++ +   VE+       Y LT+ A D   P 
Sbjct: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830

Query: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
               +S   V I VL  N+  P     L  ++ ISE   V + + ++ A+D +      +T
Sbjct: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887

Query: 650  YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
            + I  G+ +R F ++ TTGI+T+ + LDRE    Y L I+  D  P+    A  +     
Sbjct: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946

Query: 705  IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
            I ++D NDN P+F     +   +    A   +    G + A D D  I   V Y L G  
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006

Query: 760  NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
            + LF I S+  + T    V ++RE       EL+++A D  +   +ST  L I +LD +D
Sbjct: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064

Query: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
            N P F+ +T TV + EN P G ++LQ+ A D D G N  + YRI +     F  +H  TG
Sbjct: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123

Query: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
               ++R  +     +++ S    V A D  GT+P  G A VT+++ D+ND  P F   I 
Sbjct: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179

Query: 932  KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
               V   A  GT I  + A D D       ++ Y +      DD     P     F V  
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235

Query: 984  DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
            ++G V+ +  +N E    +++ +   D+          V ++  TV +L ++    P+F 
Sbjct: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294

Query: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
                 Y    + E AT GT +  ++A      +N  + Y+++         + + + G +
Sbjct: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354

Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
              N  +DYE        V   +  V  ++   P ++    VY+EI D N++ P+F +  Y
Sbjct: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407

Query: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
               V ED  + T +L V ATD D+GN++++ Y L      +G+  F +   TG I     
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462

Query: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
                ++ ++    +A D+ G   S + +  V VV Q+
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499



 Score =  274 bits (700), Expect = 6e-73
 Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)

Query: 101  RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
            R LDR+      S V+ V+  N  +G +    VR++V   D ND +P F  + Y    + 
Sbjct: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219

Query: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
            E   +GT++         ATD D G  G + Y I    +       FEI    TG I+  
Sbjct: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268

Query: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
              L+YE KT Y + + A D+A   N+   +     ++ LD           V   N    
Sbjct: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316

Query: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
               +Y+AAI E      L   IV     +ID    I          Y     T       
Sbjct: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361

Query: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
            F +   T  +++   V+R+    + L + A+ D G  + +   ++I +LDEN+ SP F  
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420

Query: 398  PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
             S     I E  PVG  ++          + A D D          L   +    F +  
Sbjct: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471

Query: 457  TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
            T  +   + + +P+DREE   Y   + A D       +  I+ + ++D NDN P      
Sbjct: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531

Query: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
             Y+V V  ++  G +V+Q+ A D D G N  ++Y I  G +   F +++ +G I   P  
Sbjct: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591

Query: 572  EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
                 ++ Y L     D   P    ++   VY+ ++  N+ +P  F Q  Y + + E   
Sbjct: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648

Query: 630  RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
             +   L+ +QA D +     ++TYAI  G+    F +    G++T  K LD E S  RY 
Sbjct: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708

Query: 686  LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
            LI+TA+D  P      TST TV + V D+NDN P F         V E +    V    A
Sbjct: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768

Query: 742  TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
             D D+G NGQV YS+ + + L  F I+    +      V+L+RE   +Y L + A D  +
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828

Query: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
             P  ST+ + I+VLDI+DN PV  N    + + EN P  + +  + A D D G N  +++
Sbjct: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888

Query: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
             I +   +  F ++  TG +++ R LD E  P+ + +I+      +      P IA    
Sbjct: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942

Query: 911  -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
              + + + D ND  P+F+K  Y+  V  ++  GTP+T     + A DAD        V Y
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000

Query: 966  RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
            ++   Q    + +F++   +G V  R  V ++ E  +  I +L+++A D G  +++S+A 
Sbjct: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054

Query: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
            + I +L   +  P F+         E  PP  S L    T       + +N  +VY I +
Sbjct: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110

Query: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
            G  +D F I+ +TGVI V N  +D E + SY L V A     V         S TA V I
Sbjct: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162

Query: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
             I D N+  P F        V E A   T +  + A D D      + Y ++    K+  
Sbjct: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220

Query: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
                   ++ F V   TG +        M +S    +++AT +    +   A  L    V
Sbjct: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272

Query: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
            SV N   + V V +V     + K   +T  ++R ++   PG  ++
Sbjct: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316



 Score =  223 bits (568), Expect = 1e-57
 Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)

Query: 390  NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
            N+ P+FT   +  Y+L  E  PVG++++         +++A D D     DP +     +
Sbjct: 26   NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72

Query: 448  YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
              S F   +   T  + L QP+DRE +  +T  FS++   GV   +   VNIQV D NDN
Sbjct: 73   EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128

Query: 506  TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
             PTF    Y V +  +   G  +  + A D D G+ G + Y     +Q  F I+   G++
Sbjct: 129  APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187

Query: 566  TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
            T+   ++    + Y LTV A   D   P     ++  +  +V        P F  L YS 
Sbjct: 188  TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243

Query: 624  EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
             I E    G  +  + A D++      I Y I +G+   +F L   +G+LTL   LDRE+
Sbjct: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303

Query: 681  ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
               +  +IL +  +    D  P D T T T NI+V D+NDNAP F+     ++++ E   
Sbjct: 304  PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362

Query: 733  NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
              F      QV   D + G+N     Y +GN ++ F I+           I  A+ L+ E
Sbjct: 363  VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422

Query: 781  VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
              D Y+  + A +    P H     + I +++ +DN P+F+   Y + + EN+  GT++L
Sbjct: 423  TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480

Query: 840  QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
             + A D D G    VSY       +  F+L   TG + L+  LDYE         T  + 
Sbjct: 481  TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534

Query: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
            A D  G    G   + V+  D+ND  P F K  Y G +  +    T +  + A D D P 
Sbjct: 535  ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591

Query: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
             P +++ Y +  V      S F++    G  +  V+  L+ E  +  +  L V+A D G 
Sbjct: 592  -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648

Query: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
            P ++S+  V I V    +  P F++  Y    V  +   G  V  ++A  +++S  Y   
Sbjct: 649  PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707

Query: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
            SI+   E  T F IN  +G I     LD ET++ Y+L V+A     V   +    K+  A
Sbjct: 708  SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762

Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
             V I + D N++ P ++   Y   + E     + V  V A D D G    + Y  I PP 
Sbjct: 763  TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821

Query: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
            K     + + + TG I+T  AML             +  V++  D G+     +  A V 
Sbjct: 822  K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877

Query: 1240 VSVVNQLDMQVIVSNVP 1256
            V++++  D      N+P
Sbjct: 878  VNLLDLNDNDPTFQNLP 894



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)

Query: 40   PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
            P+   A+ E+   GTI++  +       G    IE SL D    + +      +  L+S 
Sbjct: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463

Query: 100  GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
             R          L +D P ++ S        N++  ++   +V I V D ND  P F   
Sbjct: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512

Query: 151  SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
             +  +V E  P GT++ T       ATD D+GPNG++ Y ++         + F +  M 
Sbjct: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561

Query: 211  TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
            +G +  ++ L   +K  + + + A D  +        TT L V+V+D +D  P+F   V 
Sbjct: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613

Query: 271  VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
             PN            I  +R    L   +    + A D+D  +        + YS L   
Sbjct: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656

Query: 331  PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
                  FF + P +  +   + ++R+    + L++ A  D G P+P      L + + D 
Sbjct: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715

Query: 389  NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
            ++  P F  P   S Q  +L   E +P G  +    N+T      A+D D          
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767

Query: 443  LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
            +   +    F +   G    L +L+ +DRE +  ++F + A                D V
Sbjct: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824

Query: 488  QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
             +     V + + D ND  P F +  Y   V TD + G  +IQ+ A+DAD G+N  + Y 
Sbjct: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884

Query: 548  IL 549
            IL
Sbjct: 2885 IL 2886


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score =  281 bits (720), Expect = 3e-75
 Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)

Query: 133  VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
            V + V D NDN P F      +  +  V E  PV   + T F     A D D+G N ++ 
Sbjct: 825  VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879

Query: 189  YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
            Y +        S+D F+I     G I     L+Y+ +  Y + + A D+     + +   
Sbjct: 880  YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934

Query: 249  TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
                + +  G          ++  N R             L  PE L P  +   I++ D
Sbjct: 935  NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974

Query: 309  QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
               ++Q   +  G L+  +V   +D    F +   T +L L + ++ +    +   VI  
Sbjct: 975  ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027

Query: 368  EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
            +      L +   L I++ D+N+ SP F        + E+ P+G  +        D   L
Sbjct: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087

Query: 421  TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
             S ++              E H   N  T+ F +  +  T  L  +  +DRE   T   +
Sbjct: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131

Query: 481  ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
            +TA D       +    +   I ++D ND+ PTF  IS+ + +V  D+  G  V  +TA 
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189

Query: 535  DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
            D DEG NG++TY IL G +   F++++++GL+T    ++  +   + LTV A D+  PA 
Sbjct: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248

Query: 594  RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
              +S  T+ + VL  N+++P  F Q +Y   + E    G  +  ++A DR+      + +
Sbjct: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306

Query: 651  AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
             I  G    +F ++  TG +     LDRE  + + L +   DG  P  +ST T+   V D
Sbjct: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366

Query: 710  VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
             ND+AP F      ++ V+E +    V  V A+D DAG N  V Y +  GN +  F I  
Sbjct: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425

Query: 768  -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
             +G + T   L+RE    + LV++ +D    PR S + L ++VLD +D+SP F    Y  
Sbjct: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485

Query: 827  LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
             V E+   GT +L + A D D G N  +    + E    F + P +G L    +LD EA 
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544

Query: 886  PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
                +  TF   A D  I G+    +  + V V D+ND  PV  +  +   ++P++    
Sbjct: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600

Query: 944  PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
                V A+D D    P   V +   + Q     S+F +++ +G +  + N + E   I+ 
Sbjct: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652

Query: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
            L +   D G P   +  T  +LV+H  GE  +  F+   Y+   V+E    GT +  + A
Sbjct: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708

Query: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
             A   I  S+ YSI SGNE+    + + +G + V  P  LD+E R    L V A+S    
Sbjct: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764

Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
                         KV + IQDEN++ P F++  Y   VSE       V++V ATD D+G 
Sbjct: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818

Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
              ++ Y ++       +E F ++  +G+I T  +      S +   V ATD   KG+   
Sbjct: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872

Query: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
            ++  V  V   D   I  N P  L  + +E          ++ +PG  V   S+      
Sbjct: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921

Query: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
             AF +  + K        +P T  AID+N     L   L     DF+          E+ 
Sbjct: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959

Query: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
              E +  I    +S+ YTEGAL+
Sbjct: 1960 EYELLIQI---SDSVHYTEGALV 1979



 Score =  275 bits (702), Expect = 4e-73
 Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            + V D ND +P FK   Y A+V E    G      F     A D D G N ++++ I   
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                 S + FEI    TG +V    L+ E +  + + +   D         ++TTT+   
Sbjct: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            V D +D  P F+              +Y   + E + PE +  ++      A D D    
Sbjct: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
               +   + Y I+ G  ++    F ++  + ELS    ++R+    F LVI        P
Sbjct: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457

Query: 375  LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
              +   L + +LD N+ SP F    YQ  + E A VG  +         L + A+DKD  
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506

Query: 435  DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
            +  + +   FL D  S  FT+     T  L     +DRE +  +TFS  A D  +Q   S
Sbjct: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564

Query: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
              VI+ + V D NDN P   +  +DV++  +     + + + A D D G NG + +    
Sbjct: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623

Query: 551  GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
              Q  F I+K TG I     P  E        L ++  D   PA     +  +++E    
Sbjct: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676

Query: 609  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
                   F   +Y   ++E    G  ++ ++A   D   DS+ Y+I +G+   V +L   
Sbjct: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736

Query: 667  TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
            +G LT+   K LD E  +   LI+ A        +   V +++ D NDN+P F+  + + 
Sbjct: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794

Query: 725  LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
                 +  NA V QV ATD D+G+NG + YS+  GN    F+I + +G I T   L+ E+
Sbjct: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
               Y L+V ATD  +    +T  + ++V DI+DN+P F  S    + E++LP G  +  +
Sbjct: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913

Query: 842  EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
               DVDL +   +      +P  K  FA+   TG + L+++LD+E   + E  I      
Sbjct: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971

Query: 899  FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
                G +        V V D+ND PPVFS+  Y+  V      G  + T+ A D +    
Sbjct: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022

Query: 959  PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
                + YR+        +  F ++  +G + T    + L+   TT F  +V A D G P 
Sbjct: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073

Query: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
            + +   V+I +       P FT + Y    +SE A  G+ +   S         N  + Y
Sbjct: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132

Query: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
            SI+SGN ++ F +              G + +   LD E   S+        L ++ ++ 
Sbjct: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185

Query: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
              P  S+TA + I++ D N++PP F    Y   V E   + + +  V A D+DTG+++ +
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245

Query: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
             Y +I       K  F +E  TG++         + + F   V A+D   K  S  A V 
Sbjct: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301

Query: 1240 VSVVNQLD 1247
            VSV++  D
Sbjct: 2302 VSVLDDND 2309



 Score =  272 bits (696), Expect = 2e-72
 Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
            I V D+ND+SP+F+ E    +V E  P+GT ++   + D      DDG   N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
             +  +P +N     P    G +V   RL+ E      + + A+D+A N+ +RR  + T  
Sbjct: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            + +LD +D  P F+                  + P     E++    +   I A D    
Sbjct: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190

Query: 313  IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
              P   R G + YSIL G        F +   +  L+   P++ +   +  L + A  D 
Sbjct: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245

Query: 372  GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
               L +   L + +LD N+++P F    Y+  + E+   G  ++         R+ ALD+
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296

Query: 432  DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
            D       +  +       +F + + TG     T+L   DRE Q+ +T  +   DG    
Sbjct: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353

Query: 489  ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
             S    +   V D ND+ P F   SYD+ V  +  P + V  + A D D G+N  + Y I
Sbjct: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412

Query: 549  LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
            + G   + F IN+ +G ++    ++      + L +  +D   P   R+S+  + + VL 
Sbjct: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470

Query: 608  PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
             N+ S P FP L Y   + E   VG V+L L A D++   +  T      +    F +  
Sbjct: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529

Query: 666  TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
             +G L     LDRE+  ++     A D    G+ + TV   + VTDVNDN PV     FD
Sbjct: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589

Query: 719  PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
             +L       E   N     V+A D D G NG V +S     ++F I    G I      
Sbjct: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644

Query: 778  NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
            + E    +  + V   G   P  +T  L +  ++ +D    F++  Y  LV EN  AGT+
Sbjct: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702

Query: 838  ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
            I+ ++A   D +  ++ Y I S       +L   +G+L++   + LD+E     E  +  
Sbjct: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760

Query: 895  LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
            L E+     +       V V+++D ND  P F + IY+  V+   +    +  V+A D D
Sbjct: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815

Query: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
              GL    + Y    +        F+++  SG + T+  L+ E T+ + L+V A D G P
Sbjct: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870

Query: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
             +S++  +K+ V    +  P F   E     ++E +  G +V  +S     +N + ++S 
Sbjct: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928

Query: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
               +   T F I+  TGV+ +   LD+E  T Y L +Q +DS+                 
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977

Query: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
            + + + D N++PPVF + FY   V E   +  SVL + ATD ++     ++YR++
Sbjct: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030



 Score =  257 bits (657), Expect = 6e-68
 Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)

Query: 137  VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            V D ND++P F   SY   V  N+   V  T+         A+D+D G N  +EY I   
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
              D  +++ F I  M +G +   + L+ E  + + ++I  +D     +  R++   L V 
Sbjct: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467

Query: 255  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
            VLD +D  P F              L YQ+++   R   E+  +++   + A+D+D  + 
Sbjct: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510

Query: 315  PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
              ++     Y +     ++    F + P +  L     ++R+   +  F  V +     G
Sbjct: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561

Query: 373  HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
                    + + + D N+  P      +  ++   +P   T     +D L+L     +V 
Sbjct: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620

Query: 429  LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
               + +          ++ YT      Q   + Y  +   +   +Q           G+ 
Sbjct: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663

Query: 489  ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
                  + +  M+  D   +F    Y   V  +   G S++ + A  A +     + Y I
Sbjct: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722

Query: 549  LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
              G + G   +   +G +T+     ++  V     L V A  +        + C V + +
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
               N+ SP  F Q +Y   +SE+    A ++ + ATD +      I Y+I +G+ +  F 
Sbjct: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836

Query: 663  LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
            +   +G++T    LD E T  Y LI+ A+D G P  ++T  + + VTD+NDNAP F   L
Sbjct: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893

Query: 722  PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
            P     + E++   V     +  D  +N    +S    +N    F I  N  +   VK L
Sbjct: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953

Query: 778  NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
            + E    YEL++  +D +VH  ++   L ++VLD++DN PVF+   Y V V E++P G +
Sbjct: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010

Query: 838  ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
            +L + A D++   N+SYRI S   +  F++ P  G +  +  +      D  ++  FLVE
Sbjct: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065

Query: 898  AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
            A D        +  V + ++DMN+Y P F+ + Y   ++ DA+ G+ + T    D D   
Sbjct: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125

Query: 958  LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
               + V Y +        F      F  E   +  G ++   +L+ E +   +LV++A D
Sbjct: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184

Query: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
             G P +SS+A + I VL   + P  F+   Y    V E    G+ + V+SA       + 
Sbjct: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243

Query: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
             I+Y+I+SGNE+  F +   TGV+Y+  PLDYE  T + L VQA   E            
Sbjct: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295

Query: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
            + A V++ + D+N+H P F    +   V E+  + +++  + A D D G Y  + Y ++ 
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355

Query: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
            P      +    + F+++  TG I    +      + +   V A D        K D   
Sbjct: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407

Query: 1241 SVVNQLDMQVI 1251
            S+V  +D++ I
Sbjct: 2408 SLVVWVDIEGI 2418



 Score =  240 bits (612), Expect = 1e-62
 Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            EV I V D NDN P F   S    +++ TP GT ++        A D D G NG I Y I
Sbjct: 465  EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
                    + D     L L G++                            E+R  T TL
Sbjct: 520  ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
              +         + +  V++         T++  + ++   E L+P  +T  +Q   Q  
Sbjct: 555  RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
             + P      + YS+    P      F + P T  + L    + +  Q ++  + A   +
Sbjct: 611  PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667

Query: 371  NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
            +G        + + + DEN+ SP F +       +E +PV   +          +I A+D
Sbjct: 668  DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718

Query: 431  KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
             D    K+ +L  FL      F +   TG    + ++   D              +E Q 
Sbjct: 719  MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776

Query: 477  Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
            +                              T  +T       +  + V + V D NDN 
Sbjct: 777  FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836

Query: 507  PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
            P FP+      ++  +  G  V  L     A D DEG+N E+TY +      D F I+  
Sbjct: 837  PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896

Query: 562  TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
             G I     +      +Y ++V A D   P  +  ++  V I+V+ P ++      Q + 
Sbjct: 897  NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953

Query: 622  SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
             L I E ++   ++  ++++D         + ++I   D    F +  +TG L L K LD
Sbjct: 954  HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013

Query: 678  RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
             E+T  Y+  +  +D   + + ++TV  +I V D ND++P F       L V+  E N  
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069

Query: 736  VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
            +G +     A D D   +N ++ Y + + N   N F I  S G++ T  +L+RE      
Sbjct: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129

Query: 787  LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
            L V A+D AV+    R  +LT  I +LD++D++P F  S     V+E++  G+ +  I A
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188

Query: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
             D D G N  V+Y I S      F L   +G L+    LDYE     +      V A D 
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244

Query: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
                     T+TV V D+ND  PVF + +Y+  V  +   G  +T V A D D      S
Sbjct: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298

Query: 962  RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
             V  ++     P  +  +FE+  D+G V+T   L+ E   +F L V+  D G P +SS+ 
Sbjct: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358

Query: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
            T+   V    +  P F    Y    +   E     T++     A  N+++ Y I+ GN +
Sbjct: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418

Query: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
            + F IN ++G +     LD E  +++       +L ++ ++L  P +S+   + + + D 
Sbjct: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
            N+H P F   +Y   V EDA + T VL + A DKD G      Y L      E    F +
Sbjct: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527

Query: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
            +  +G +KT+       RS   F  +A D
Sbjct: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556



 Score =  231 bits (590), Expect = 3e-60
 Identities = 266/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)

Query: 103  LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
            LDR+  P  I ++    Q +N     +     +IV+ D ND++PTF      A V E   
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178

Query: 162  VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
            VG+ +         A D D+G NG++ Y I    +    N TF +    +G +     L+
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228

Query: 222  YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
            YE KT++ + + A D         +++ TLTV VLD +D  P+F            +   
Sbjct: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273

Query: 282  YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
            Y+A++ E + P E         ++A+D+D  +        + + I+ G   +    F ++
Sbjct: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320

Query: 342  PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
              T E+     ++R+  + F L +   +D G P L +   +   + DEN+ +P F + SY
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379

Query: 401  QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
               +LE+       +          ++A D D  + +  E H+   +    FT+ +  ++
Sbjct: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427

Query: 461  RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
              L+  + +DRE+   +T  I   D      S  + + ++V+DAND++P+FP + Y   V
Sbjct: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487

Query: 519  YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
              D   G  V+ L+AVD DEG NG+  Y +   A G F I+  +G +  +  ++      
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547

Query: 579  YALTVQAADNAPPAERRNS-ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
            +  +  A D +    R  + I  VY+  +   N + P   Q  + + +S         + 
Sbjct: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDV---NDNDPVLEQNPFDVFLSPESPTNQTTVI 1604

Query: 638  LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
            ++A D + G + T      + Q +F++ + TG +   +    E    ++ +     G P 
Sbjct: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664

Query: 697  GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
             T+T  + ++  +  D    F  +L + L     EA   +  VKA  PD+ I   + YS+
Sbjct: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722

Query: 757  --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
              GN + +  + S     T  +   L+ EVR+  +L+V+A         +   +A+ + D
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779

Query: 812  IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
             +DNSP F  S Y   V E+      ++Q+ A D+D G N  + Y I S   +  F +  
Sbjct: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839

Query: 870  FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
             +G ++    LDYE      +S + +V+A D           + V V D+ND  P F  S
Sbjct: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895

Query: 928  KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
            + +    +  D++ G  +T V   D D          +     +   P + F +++++G 
Sbjct: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946

Query: 988  VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
            V+    L+ E  T ++L++   D    V  +   + + VL   + P    +++    V E
Sbjct: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003

Query: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
                G  V  +SA  +  N++I Y I+S ++E  F I+   G I+   P   LD  + T 
Sbjct: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061

Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
            +++                P       V I I+D NN+ P F  K Y   +SEDA + ++
Sbjct: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112

Query: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
            ++     D D T   + + Y +I
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSII 2135



 Score =  215 bits (547), Expect = 3e-55
 Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
            ST R LDR+   N   +++     +    ++I+ +VR++  D ND+SP+F    Y ++V 
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488

Query: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
            E   VGT +         A D D+G NGQ EY +    D+ +   T +    ++G +   
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537

Query: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
              L+ E ++++     A D +  +   R+TT  + V V D +D  P     VL  N  D 
Sbjct: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590

Query: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
                         +PE  +P   T  I   D D ++ P      +++S       +    
Sbjct: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628

Query: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
            F +   T E+   +  + ++   + L +K   D G P     GL +  ++  +    F+ 
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686

Query: 398  PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
              Y+G + E+   G         TS + + A   D I+D+   +  +F  +   V ++  
Sbjct: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735

Query: 457  TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
               +  LT+ +P  +D E +      + A      +   +  + + D NDN+P F +  Y
Sbjct: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792

Query: 515  DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
               V         VIQ+ A D D G NG I Y IL G Q + F I+  +G+IT    ++ 
Sbjct: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852

Query: 574  IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
             +  +Y+L VQA D   P  R ++   + ++V   N+ +P   P    ++EI+E    G 
Sbjct: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908

Query: 634  VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
            ++ ++   D + +S    ++A E+ +P   F + + TG++ L K LD E    Y L+I  
Sbjct: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967

Query: 691  SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
            SD          V ++  DVNDN PVF     +            V  + ATD ++  N 
Sbjct: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023

Query: 751  QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
             + Y + + +  F I   NG+I+T +  L  +     + +V A+DG  +P    LTL  I
Sbjct: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082

Query: 808  KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
             + D+++ +P FT  +Y + + E+   G+T++     D D       V Y I S      
Sbjct: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142

Query: 860  ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
               E K F + +P+   G L LL SLD EA     AS   ++ A D         A +++
Sbjct: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198

Query: 915  IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
             V D+ND PP FS   Y   V      G+ IT V A D D  G  A  +   +   +  +
Sbjct: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257

Query: 975  PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
                F +EE++G +     L+ E  T F L V A  D E    S A V + VL   +  P
Sbjct: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312

Query: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
            +F    +       L    T+  + +    A     + YSIVS          + D F I
Sbjct: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372

Query: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
            + +TG I+    LDYE    Y L VQA       A+L          V+++I+  +   P
Sbjct: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423

Query: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
            +F +  Y   + E  +    + RV+A+D D G   V+ Y L
Sbjct: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464



 Score =  214 bits (544), Expect = 7e-55
 Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)

Query: 45   AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
            ++ E++  GT+++    +    G    T E  L D       +DP+   L    T   LD
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541

Query: 105  RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
            R+    +  S V +   I     T +   +++ V D NDN P  +   +   ++  +P  
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599

Query: 164  -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
             TT+         A D+D GPNG + +          +   F I    TG I  ++  + 
Sbjct: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646

Query: 223  EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
            E    YF I +Q     Q +  R  TTT L V  ++G+D+   F   +            
Sbjct: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688

Query: 282  YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
            Y+  + E     E    IVT    A        P S +  + YSI  G  +       + 
Sbjct: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734

Query: 342  PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
             ++ +L++ EP   DF    +  L++ AE  +GH   A+  + + I DEN+ SP F    
Sbjct: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791

Query: 400  YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
            YQ  + ES    A +         +++ A D D       E  +   +    F +    +
Sbjct: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840

Query: 460  TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
            +  +T    +D E   +Y+  + A D G+   S   ++ +QV D NDN P F   S  V 
Sbjct: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899

Query: 518  VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
            +  D  PG  V  ++  D D  S    ++         F I++ TG++ +   ++     
Sbjct: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959

Query: 578  TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
             Y L +Q +D+    E       + + VL  N+ +PP F Q  Y + + E++ VG  +L 
Sbjct: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013

Query: 638  LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
            L ATD E  ++I+Y I +   +  F++    G I T+   L  ++      ++ ASDG  
Sbjct: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071

Query: 695  PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
            PD  +   V I + D+N+ AP F      NLS+ E+   A VG    T    D D    N
Sbjct: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127

Query: 750  GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
              V YS+  GN  N F + +            G +     L+RE    +ELV++A+D   
Sbjct: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187

Query: 797  HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
             P  ST  ++I+VLD++DN P F++ +Y   V+E+ P G+ I  + A D D G  A + Y
Sbjct: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247

Query: 855  RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
             I S   K  F L   TG L L++ LDYE    +    T  V+A D         A V V
Sbjct: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302

Query: 915  IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
             V D ND+ P F    +  +V  +    + I ++ A D D    P   + Y +    F  
Sbjct: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360

Query: 973  ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
                Y   +F ++  +G +  +  L+ E    + L V A D G+   S    V I  +  
Sbjct: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420

Query: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
             E P FTQ++Y    P    +    G +    + A I+  I+YS+  G     F +N   
Sbjct: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477

Query: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
            G IY+   L      S + +     ++++  + +  SK  +  V++ +   +   P  VF
Sbjct: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535

Query: 1145 QKKFYI 1150
               F I
Sbjct: 2536 ASSFSI 2541



 Score =  212 bits (539), Expect = 3e-54
 Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)

Query: 30   DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
            D+ ++++  PP T +    A D +S RNG       LI+ +   P P +           
Sbjct: 485  DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526

Query: 85   VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
              +D    +LFLN S G    R+  + + +   + Q ++ +   ++      VV ++ ++
Sbjct: 527  FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579

Query: 144  SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
            SP  TF+H  Y   V+E L+P+   + T             GP  +    ++Y+ +    
Sbjct: 580  SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630

Query: 201  NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
            +  F I    TG I LR++ +YE    Y    F  I  +   QN++      TT+ V V 
Sbjct: 631  SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683

Query: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
            D +D  P FL  VL                  L+  E   P  V   I AID D      
Sbjct: 684  DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726

Query: 312  ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
                         + P +   G +Y I          GT      D  + F +     EL
Sbjct: 727  LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786

Query: 348  SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
               E +N     R+     ++ +        P  A   +++ + D N+  P+F   +P  
Sbjct: 787  GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846

Query: 401  QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
            + +  +LE  PV   ++          + A D D  +  +    +   D +  F +    
Sbjct: 847  ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897

Query: 458  GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
            G  R  T+L     + + +Y  S+ A D GV   +   +VNIQV+  +       +    
Sbjct: 898  GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954

Query: 516  VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
            + +  +++P   +  + + D   +  NG++ + I+     G F I+ +TG + ++  ++ 
Sbjct: 955  LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014

Query: 574  IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
                 Y   V   D+   ++  +   TV++ + +   N   P F   +  + + E + +G
Sbjct: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071

Query: 633  AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
             ++    A D +G      I Y IE+ +P    F +  + G L     LDRES    IL 
Sbjct: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131

Query: 688  ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
            +TASD   + T     + T  IV+ DVND+ P F  +   N  V E+    + V  + A 
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189

Query: 743  DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
            DPD G NG+V YS+  GN N  F +  S+G + T   L+ E++  + L V+A D      
Sbjct: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249

Query: 800  HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
             S+ TL + VLD++D +PVF    Y   V+EN   G  + ++EA D D G N  + + I 
Sbjct: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309

Query: 858  SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
                   F ++  TGE+     L      D+E    F +      G  P   +T T++  
Sbjct: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363

Query: 916  VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
            V+D ND+ P F    Y   V  +  +   + TV A D D     A  V Y + D      
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417

Query: 976  ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
               F + E SG + T   L+ E  + F LV++  D G+P  SS   +++ VL   +    
Sbjct: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477

Query: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
                Y    V E A  GT+V V+SA      +N    Y  ++      F I+ ++G +  
Sbjct: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536

Query: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
            +  LD E R+ +     A    +        S+S T  + + + D N++ PV ++  +  
Sbjct: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590

Query: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
             +S ++    + + V+A D D G    + +        E +  F ++ YTG I+
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639



 Score =  199 bits (505), Expect = 2e-50
 Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)

Query: 363  LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
            L++ A+   G      A + I I         F  P Y   + E  P            S
Sbjct: 345  LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394

Query: 423  PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
            P+  V   + +  ++     +   D    F++  + G  R     +P+D E Q     ++
Sbjct: 395  PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451

Query: 482  TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
             A  G   +     VNI VMD NDN P F   S ++ +     PG ++    A D D G 
Sbjct: 452  QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511

Query: 541  NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
            NG I Y I     G F I++  G++ +   +     R   LT++A D     +    + T
Sbjct: 512  NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571

Query: 601  VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
            V IE       SP   F  L+Y +E+SE++     +L  QA      R    + Y++E  
Sbjct: 572  VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628

Query: 656  DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
                +F +   TG + L +  D EST  Y   + A    DG     ST TV + V D ND
Sbjct: 629  VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687

Query: 713  NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
            N+P F   L   L +  EE+      +G++ A D D+G NGQ+ Y L +    F++  N 
Sbjct: 688  NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744

Query: 769  ---GSIYTA-----------------------------------------VKLNREVRDY 784
               G+IY                                           V L+RE R +
Sbjct: 745  GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804

Query: 785  YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
            +E+ V+ TD    PR++T+ + + V DI+DN P F          V V E  P    +  
Sbjct: 805  HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864

Query: 841  IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
            + AKD D G  A V+Y + S +    F +    GE+     L Y+  P    S+    + 
Sbjct: 865  VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924

Query: 899  FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
                  +PP  G A V + V  ++    + S+ I + ++ P+ +K T I ++        
Sbjct: 925  ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977

Query: 957  GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
                 ++ + +  DD         FE++  +G +     L+ E T+ +   V+  D  + 
Sbjct: 978  QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032

Query: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
            + +SS+  + I V    +     Q+E     V E    GT+V V +A     + +N  I 
Sbjct: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092

Query: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
            Y I S N   + F I+   G +     LD E+  + +L V A    V + + R+  +S T
Sbjct: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150

Query: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
            A+  I I D N+H P F   F    V ED  + + V  + A D D G    + Y ++   
Sbjct: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204

Query: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
               G E   F+++  +GL+ T        ++     V+A DD    LS    + V+V++ 
Sbjct: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262

Query: 1246 LD 1247
             D
Sbjct: 1263 ND 1264



 Score =  188 bits (477), Expect = 4e-47
 Identities = 254/1092 (23%), Positives = 453/1092 (41%), Gaps = 126/1092 (11%)

Query: 314  QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
            +P +    I Y I  G   D    F +HPR   +   +P++ +      L ++A+  +  
Sbjct: 403  EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458

Query: 374  PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
            P  +   ++I ++D N+  P F   S +  I ++ P G  +            +A  +D 
Sbjct: 459  PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507

Query: 434  EDTKDPELHLFL-NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE 491
            +  ++  +   + +    VF + +      L L   +   EQ+  T ++ A D GV    
Sbjct: 508  DSGRNGLIRYSIASPQPGVFAIDRA--LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 565

Query: 492  PVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEI 548
             ++V   V++  +++P  TF  + Y V V   + P   ++Q  A     + +   + Y +
Sbjct: 566  ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL 625

Query: 549  LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
                    F I   TG I +    +    +TY   V A         +N   TV + V  
Sbjct: 626  EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVWD 684

Query: 608  PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNL 663
             N+ SP     +++ L++ E+     V+  + A D    + G  + + + +G   + F +
Sbjct: 685  ENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFKM 740

Query: 664  SETTG------ILT-------------------------------LGK-------ALDRE 679
            +  TG      ++T                               LG+       ALDRE
Sbjct: 741  NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800

Query: 680  STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEANA 734
                + + +  +D G P   +T  V + VTD+NDN P F   LP    ++ V+E +  N 
Sbjct: 801  HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 860

Query: 735  FVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
             V  V A DPD G N +V YS+   + ++ F+I  +NG I T   L+ + R  Y + V+A
Sbjct: 861  LVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920

Query: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDL 848
            TD  V P      + I+V+ +     + + +   +++ ENL     +  I++ D      
Sbjct: 921  TDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHY 980

Query: 849  GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-P 907
               + + I + +    F +   TG+L L + LDYE      +   F V   D    +   
Sbjct: 981  NGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSLS 1036

Query: 908  GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
                +++ V+D ND+ P F   +    V  +   GT +    A+D D   L  SR++Y +
Sbjct: 1037 STVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYYI 1095

Query: 968  DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVKI 1024
            +        + F +    G ++T   L+ E      L V A D    V      S T +I
Sbjct: 1096 E--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153

Query: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDT 1079
            ++L   +  P F    +    V E  T G++V  I+A       N  + YSI+SGNE  T
Sbjct: 1154 VILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT 1211

Query: 1080 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
            F ++  +G++    PLDYE +T ++L V A        +   P+ S++  + + + D N+
Sbjct: 1212 FMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVND 1264

Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
              PVF++  Y   V E+      V RV+A D+D+G  S + +  I+P      E F + +
Sbjct: 1265 EAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEINS 1321

Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTL 1259
             TG + T  +     +  F  +V+  D     LS    +L +V ++ D      + P  +
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEFI 1375

Query: 1260 VEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ--T 1317
            V     D+ E+L+    E +          G  R  +   ++  T    T+  +  +  T
Sbjct: 1376 VSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELST 1432

Query: 1318 NRAIDRNELFKF 1329
             RA+DR ++  F
Sbjct: 1433 TRALDREQISNF 1444



 Score =  136 bits (342), Expect = 2e-31
 Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)

Query: 462  YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
            YLTL  P+   E  T +  ++A DG   +  +   V I +         F    Y   VY
Sbjct: 330  YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387

Query: 520  TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
             D+ P DS I          S+  I Y I  G   G F I+   G I     ++      
Sbjct: 388  EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446

Query: 579  YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
              LTVQA   + PA     +    ++V    N + P F +    + IS+    G  L   
Sbjct: 447  VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502

Query: 639  QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
            +A DR+      I Y+I +  P  VF +    G+L L  +L         L + A D   
Sbjct: 503  RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561

Query: 696  DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
               +   V  VV +  +++P       V+   +  +LS    +++ +A+  +G  +A  P
Sbjct: 562  HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620

Query: 745  DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
                   + YSL     + +F I    G IY   + + E    Y   V A    DG +  
Sbjct: 621  -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671

Query: 799  RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
            ++ + T+ ++V D +DNSP F +    + VEE+      I +I A D+D G N       
Sbjct: 672  QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731

Query: 859  PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
                 FF ++P TG    +  + +            AF   E     L   F   G    
Sbjct: 732  LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791

Query: 905  ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
                                     PP  AT+ V V   D+ND  P F + +    +   
Sbjct: 792  INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851

Query: 939  AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
             ++G P    +TTV+A+D D      + V Y V        +  F+++ ++G + T   L
Sbjct: 852  VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906

Query: 995  NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
            + +    +++ V+A D G P +   A V I V+   +      +  R   + E      +
Sbjct: 907  SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966

Query: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
            + +I ++       N  + +SIV+ +++  F I++ TG ++++  LDYET + Y+ RV  
Sbjct: 967  MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024

Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
                +   + +  S S+T  + I+++D+N+H P FQ +  +  V E+  + T V    A 
Sbjct: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080

Query: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
            D D G++     +  I     G   F++    G + T
Sbjct: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116



 Score =  130 bits (326), Expect = 1e-29
 Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)

Query: 467  QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
            Q +DRE +  TY   + A DG ++            S    V + + D NDN P F   +
Sbjct: 122  QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181

Query: 514  YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
            Y   +  + +PG  +I + A D D G  G + YE++ G     F I+ TTGL   +P VE
Sbjct: 182  YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239

Query: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
            ++    ++   +  ++    E    +   + +V      +  +F     + +       +
Sbjct: 240  ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296

Query: 632  GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
              + +  +A   +G++          + V NL++    GI+ L   L    +    L+++
Sbjct: 297  HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348

Query: 690  ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
            A DG   G  TA +N  VT       +F   L       P+   +V E+   ++ +G VK
Sbjct: 349  AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400

Query: 741  ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
            A +P    +  + Y  S G+    F I    G+I T   L+ E +    L V A  G+  
Sbjct: 401  AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458

Query: 798  PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
            P  S+  + I V+D++DN P F  ++  + + +  P GT +    A+D D G N  + Y 
Sbjct: 459  PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518

Query: 856  IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
            I SP+    FA+    G L L  SL       ++  +T  + A D  G  P     V  +
Sbjct: 519  IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572

Query: 916  VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
            V +  ++ P   F   +Y+  V+      +P+T +    A P  P   AS +RY ++   
Sbjct: 573  VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627

Query: 972  FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
                +++F +   +G +  R   + E T  +   V A+  +DG  + + S TV + V   
Sbjct: 628  -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685

Query: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
             +  P F  +      E  P P   +   G +  +   +  N  ++Y ++S  +   F +
Sbjct: 686  NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740

Query: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
            N  T   G IYV             +     +   ++VL+              V  D  
Sbjct: 741  NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800

Query: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
                  + V++ +   P ++ T  VY+ + D N++ P F      K+ ++  V E   + 
Sbjct: 801  HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859

Query: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
              V  V A D D GN + + Y +     ++  + F ++   G I+T  +     R  ++ 
Sbjct: 860  MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916

Query: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
             VIATD     L G+A V + V+     + I+S       +P  L   KI  L +  D  
Sbjct: 917  SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976

Query: 1275 VQ 1276
             Q
Sbjct: 977  QQ 978



 Score =  112 bits (279), Expect = 4e-24
 Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)

Query: 530  QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
            ++TA DAD G  G I Y +  G     A   F I+   G I ++  ++      TY L V
Sbjct: 78   EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 584  QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
            +A D     +R   +  V        ++ V L   N + P F    Y   IS+  + G  
Sbjct: 138  EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195

Query: 635  LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
            ++N+ ATD++     ++ Y +  G+   +F +  TTG+ +                    
Sbjct: 196  IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235

Query: 692  DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
               P+    + VN     +V ++  +F P L R+   VE +  A              F 
Sbjct: 236  ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291

Query: 737  GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
            G+     +K  D  A  +G+   +     NL +I   G IY  + L+        L+V A
Sbjct: 292  GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349

Query: 792  TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
             DG          + I +         F    YT LV E++P  + I  ++A++ ++   
Sbjct: 350  QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409

Query: 851  NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
             + YRI S ++   F++HP  G +   + LD+E  P     +   V+A    G+ P   +
Sbjct: 410  PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463

Query: 911  T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
            T V + V D+ND  P F +   +  ++     GT +    AED D    GL    +RY +
Sbjct: 464  TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519

Query: 968  DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
               Q      +F ++   G +    +L         L + A D G    ++   + +++ 
Sbjct: 520  ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575

Query: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
                 P +T E         E   P    L T+   +G   AA+    + YS+    +  
Sbjct: 576  KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632

Query: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
             FGI   TG IY+    DYE+  +Y  RV A   E   L N+       +  V + + DE
Sbjct: 633  MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
            N++ P F        V E       + ++ A D D+G    + Y L+
Sbjct: 686  NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)

Query: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
            F  +E    PV E     +         I  S+    +S      F I+   G I V+  
Sbjct: 64   FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123

Query: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
            +D E    +Y L V+A D  E  + +L +     +A+ ++  +++D N++ PVF    Y+
Sbjct: 124  IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183

Query: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
              +S++ +  T ++ V ATD+D+G Y  +AY LI   +      F +++ TGL
Sbjct: 184  TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)

Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
           VR+ + D NDN P F   +Y  ++++ T  GT I         ATD D G  G + Y
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score =  278 bits (712), Expect = 2e-74
 Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)

Query: 282  YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
            YQ  +PE       N    T  ++ + QD    P +   G ++YS+           F +
Sbjct: 330  YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378

Query: 341  HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
             P++  +     ++R+  ++  L + A QD+G P L A   + + + D N+ SP F    
Sbjct: 379  DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437

Query: 400  YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
            Y+  + E+   G  I         L++ A D D     +                    I
Sbjct: 438  YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488

Query: 460  TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
                 L+     VDRE  ++Y   + A D  QE  P    V V+I V+D NDN P F E 
Sbjct: 489  DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548

Query: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
             Y   V  D+RP   V+++TA D D+ +NG + Y I+ G ++G F I+  TG I +   +
Sbjct: 549  RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608

Query: 572  EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
            +    R YAL ++A D   PP      + ++ +  +   N   P F    + + + E   
Sbjct: 609  DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665

Query: 631  VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
            +G  ++++QA D    E   + Y++    P   F ++  TG +++   LDRES + Y   
Sbjct: 666  LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725

Query: 688  ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
            + A D G P  +++A+V + V DVNDN P F   +      + E+A      V  T  D 
Sbjct: 726  VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783

Query: 747  GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
              N  + Y +  GN  N F I++ G    +  A+ L+ +   Y++LV+ A+D A+H    
Sbjct: 784  DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841

Query: 802  TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
               + I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N        + 
Sbjct: 842  -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900

Query: 862  KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
               F +   +G ++L   LDYE     + + T  + A D           V V+V D+ND
Sbjct: 901  LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956

Query: 922  YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
              P F    Y G+V+ DA   T +  + A D D       RV+Y   + +       F +
Sbjct: 957  NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012

Query: 982  EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
            E  SG V T   L+ E  ++++L   A D G P + +  +++++V    +  P F  EE+
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072

Query: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
                V E +  G++V  I+A       N  I+Y IV GN  + F ++  +G +     LD
Sbjct: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131

Query: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
            YE R  YV+ VQA S  +V          + A V++ + D+N++ PV    +  +   VS
Sbjct: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181

Query: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
              +  F S  + R+ A D D  ++
Sbjct: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205



 Score =  274 bits (701), Expect = 5e-73
 Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V + V DRND+SP F+   Y  T+ E    G  I         ATD D  PN  + Y   
Sbjct: 419  VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473

Query: 193  YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
              P     +   FEI    +G I    R++ E    Y ++++A+D+ Q    R + T  +
Sbjct: 474  GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             + VLD +D  P F     V   R                 E++ P  V   + A D+D+
Sbjct: 532  HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574

Query: 312  NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
                  D  G++ Y+I+ G    +   F +   T E+ ++ P++ +  +++ L I+A+  
Sbjct: 575  ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625

Query: 371  NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
               PL    GL  I+++D N+  P F    +Q  +LE+AP+G ++         + I A+
Sbjct: 626  GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676

Query: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
            D D  +    E  L      + F +     T ++++  P+DRE  + Y F + A D    
Sbjct: 677  DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734

Query: 490  --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
              S    V + V+D NDN P F    Y + +  D   G SV+ +TAVD D  +N  I+Y+
Sbjct: 735  PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792

Query: 548  ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            I  G  +  F I+     GL+T+A  ++    R + L + A+D A      +  C V+I 
Sbjct: 793  ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847

Query: 605  VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
            +   N   P  F    YS+ ++E   +G+ ++ + A+D    E   ITY +E+  PQ  F
Sbjct: 848  ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904

Query: 662  NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
             +   +G +TL   LD E    Y L ITA D G P    T  V ++V DVNDNAP F   
Sbjct: 905  RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962

Query: 721  LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
                  +V E+A  F    Q+ ATD DA  NG+V Y+  N  +    F I  ++G + T 
Sbjct: 963  ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
             +L+RE    YEL   A D  V P  + +++ + V D++DN+PVF    + V V+EN   
Sbjct: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082

Query: 835  GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
            G+ + QI A D D G  A++ Y+I    +   F +  F+GEL+ L  LDYEA   QE  I
Sbjct: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140

Query: 893  TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
                    +  T  P ++  TV V+  D ND  PV +
Sbjct: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170



 Score =  249 bits (637), Expect = 1e-65
 Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)

Query: 145  PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
            P F   +Y   V E    GT +         A D D G  G++ Y +    +   S + F
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376

Query: 205  EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
             I    +G I     L+ E   R+++ + A D     + R + TT + V V D +D  P+
Sbjct: 377  SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432

Query: 265  FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
            F                Y+  + E    EE  PI+    ++A D D    PP+     L 
Sbjct: 433  F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469

Query: 325  SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
               VG P         F + PR+  +S    V+R+  + ++LV++A      P P  A  
Sbjct: 470  YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529

Query: 380  GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
             +HI +LDEN+ +P F+   Y   + E         D    T  LR+ A D+D +     
Sbjct: 530  RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580

Query: 440  ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
              ++   +    F +    +T  + ++ P+D E ++ Y   I A D  +    +   + +
Sbjct: 581  HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638

Query: 497  IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
            IQV+D ND+ P F    + V V  +   G SVI + AVDAD G N  + Y +  V     
Sbjct: 639  IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698

Query: 556  FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
            F+IN  TG ++++  ++      Y   V+A D+ +PP     S+    ++V    N + P
Sbjct: 699  FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754

Query: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
             F    Y L ++E   VG  ++++ A DR+ +S I+Y I  G+ +  F +S     G++T
Sbjct: 755  EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814

Query: 672  LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
            L   LD +    + L++TASD          +NI  TD N + PVF      ++SV E+ 
Sbjct: 815  LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871

Query: 732  A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
               + +  + A+D D G N ++ Y L +    FRI ++ G+I     L+ E +  Y L +
Sbjct: 872  PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931

Query: 790  VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
             A D  +  +  T  + + V D++DN+P F  S YT LV E+ P  T++LQI A D D  
Sbjct: 932  TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991

Query: 850  AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
            AN  V Y  ++ E     F + P +G +  +R LD EA    E +      A+ +   +P
Sbjct: 992  ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045

Query: 907  P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
            P     ++ V+V+D+ND  PVF    ++  V  +++ G+ +  + A D D    P + + 
Sbjct: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103

Query: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
            Y++ +   P    +F+++  SG +   ++L+ E    + +VV A     P++S +     
Sbjct: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158

Query: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
            LV      P     +          +     G+I         ++  + YS   GNE   
Sbjct: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218

Query: 1080 FGINNITGVIYVNGPLD 1096
              +N  +G + ++  LD
Sbjct: 1219 LVVNQTSGELRLSRKLD 1235



 Score =  246 bits (629), Expect = 1e-64
 Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)

Query: 390  NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
            N+ P F   +YQ  + E+   G         T+ LR+VA D D  +       L   +N 
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370

Query: 448  YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
             +  +F++  Q+G+ R    L   DRE  + +   +TA D    + S   +V + V D N
Sbjct: 371  RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427

Query: 504  DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
            D++P F +  Y   +  ++  G  ++QL A D D   N  + Y  +        A   F 
Sbjct: 428  DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487

Query: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
            I+  +GLI+ +  V+     +Y L V+A+D       R++   V+I VL  N+ + P+F 
Sbjct: 488  IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546

Query: 618  QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
            +  Y  ++ E +R   V+L + ATDR+ D+   + Y I +G+ +  F +   TG + +  
Sbjct: 547  EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606

Query: 675  ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
             LD E+   Y L I A D GRP    +T   +I V D+ND+ P+F    P  +SV+E   
Sbjct: 607  PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662

Query: 733  NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
            NA +G     ++A D D G N ++ YSL     +  F I S  G +  +  L+RE  ++Y
Sbjct: 663  NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722

Query: 786  ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
               V A D    P  ++ ++ + VLD++DN P FT   Y + + E+   GT+++ + A D
Sbjct: 723  FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782

Query: 846  VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
             D  + +SY+I     ++ FA+      G ++L   LDY+    QE     ++ A D   
Sbjct: 783  RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835

Query: 904  TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
                    V + + D N + PVF    Y   V  D   G+ I  + A D D      +R+
Sbjct: 836  RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893

Query: 964  RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
             Y ++D   P     F ++ DSG +  +  L+ E    + L + A D+G P  + +  V+
Sbjct: 894  TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948

Query: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
            ++V    +  P+F    Y    VSE A   T V  ISA    A  N  + Y+  +G + D
Sbjct: 949  VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007

Query: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
              F I   +G++     LD E  + Y L   A        +  VP       + + +QD 
Sbjct: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
            N++ PVF  + +   V E++ + + V ++ A D D G  + + Y+++   I    E F +
Sbjct: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117

Query: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
            + ++G +   + L +  R+ Y    VI        L  +A V V +V+Q D   +++N
Sbjct: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171



 Score =  233 bits (595), Expect = 9e-61
 Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)

Query: 502  ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
            A +  P FP+ +Y   V  +   G +V+++ A D D G  G + Y +           F 
Sbjct: 318  AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377

Query: 558  INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
            I+  +GLI  A  ++      + L V A D+  P   R S  T+    +   N   P F 
Sbjct: 378  IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434

Query: 618  QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
            Q  Y   + E +  G  +L L+ATD +     ++ Y        R      F +   +G+
Sbjct: 435  QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494

Query: 670  LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
            ++    +DRE  + Y L++ ASD G+  G  +ATV + +T  D NDNAP F     R ++
Sbjct: 495  ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552

Query: 727  VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
             V E+   +  V +V ATD D   NG VHY++  GN    F I S  G I     L+ E 
Sbjct: 553  QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612

Query: 782  RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
               Y L + A D    P  +   LA I+V+DI+D+ P+F ++ + V V EN P G +++ 
Sbjct: 613  EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672

Query: 841  IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
            I+A D D G N  + Y +        F ++  TG +S+   LD E+         F VEA
Sbjct: 673  IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728

Query: 899  FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
             D +G+ P    A+VTV V D+ND  P F+ + Y   +  DA  GT + +V A D D   
Sbjct: 729  RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786

Query: 958  LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
               S + Y++         +I   +   G V   + L+ +    FKLV+ A D     + 
Sbjct: 787  ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839

Query: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
                V I +          Q  +    V+E    G+ + VISA+      N  I Y +  
Sbjct: 840  DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899

Query: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
               +  F I+  +G I +  PLDYE + +Y L + A        +  +P K++T  V + 
Sbjct: 900  NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950

Query: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
            + D N++ P F    Y G VSEDA  FTSVL++ ATD+D      + Y       + G++
Sbjct: 951  VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005

Query: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
            G   F +E  +G+++T         S ++    A D
Sbjct: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041



 Score =  135 bits (339), Expect = 4e-31
 Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V + V D NDN P F  + Y+  +NE   VGT++ +        T +D   N  I Y I 
Sbjct: 742  VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794

Query: 193  YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
                   + + F I      G + L   L+Y+ +  + +++ A+DRA + +        +
Sbjct: 795  GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
             +++ D +   P+F       +  + RP+               + I+V   I A D D 
Sbjct: 845  HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                  +   I Y +    P+     F +   +  ++L  P++ +    + L I A +DN
Sbjct: 887  ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936

Query: 372  GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
            G P  A    ++E++  D N+ +P F    Y G + E AP           TS L+I A 
Sbjct: 937  GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986

Query: 430  DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
            D+D       + + F N  D    FT+  T GI R +  L   DRE    Y  +  A D 
Sbjct: 987  DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042

Query: 486  GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
            GV     PV + + V D NDN P FP   ++V V  +   G  V Q+TAVD DEG N  I
Sbjct: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102

Query: 545  TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
             Y+I+ G   + F ++  +G +T    ++    + Y + VQA  +AP   R     TV++
Sbjct: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157

Query: 604  EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
             ++  N+ SP     Q++++  +S         ++  + A D +  D + Y+ E G+  +
Sbjct: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
            +  +++T+G L L + LD        +++T +DG    T+   + +V+
Sbjct: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score =  268 bits (685), Expect = 3e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301

Query: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356

Query: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416

Query: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475

Query: 633  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535

Query: 690  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594

Query: 747  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654

Query: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714

Query: 847  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768

Query: 905  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825

Query: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880

Query: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939

Query: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047

Query: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096



 Score =  265 bits (677), Expect = 3e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363

Query: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412

Query: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465

Query: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506

Query: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566

Query: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615

Query: 457  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675

Query: 498  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733

Query: 557  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788

Query: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845

Query: 672  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905

Query: 731  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965

Query: 787  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025

Query: 846  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076

Query: 904  TMPPGI--ATVTVIVKDMNDYPPV 925
            T  P +  ATV +++ D ND PPV
Sbjct: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100



 Score =  252 bits (644), Expect = 2e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354

Query: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404

Query: 457  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461

Query: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521

Query: 571  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579

Query: 631  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639

Query: 671  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698

Query: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756

Query: 784  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813

Query: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867

Query: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925

Query: 962  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980

Query: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039

Query: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089

Query: 1133 EIQDENNHPPV 1143
             + D+N++PPV
Sbjct: 1090 LLVDQNDNPPV 1100



 Score =  226 bits (575), Expect = 2e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468

Query: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517

Query: 216  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573

Query: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610

Query: 331  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670

Query: 379  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719

Query: 439  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778

Query: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837

Query: 559  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894

Query: 619  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954

Query: 675  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011

Query: 733  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071

Query: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127

Query: 842  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185

Query: 898  AFDIYGTMPPGIATVTVIVKDM 919
            +   + T+      VT+I  DM
Sbjct: 1186 SVTAFCTL-----RVTIITDDM 1202


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  266 bits (681), Expect = 1e-70
 Identities = 321/1207 (26%), Positives = 520/1207 (43%), Gaps = 141/1207 (11%)

Query: 77   LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
            L D + Y++L        V+    L + G   DR+   + H + V+V+  N+    +   
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
             VR+ + D NDN P FKH  YY  + + T  G  +F        ATD D G NG + Y  
Sbjct: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109

Query: 192  QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
                +D T    F I   L G+I L+K  +Y+   +Y + + A D               
Sbjct: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149

Query: 252  TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
            T  +   ++        VLV       PL +Q+   ++R PE  N  + TP +    Q R
Sbjct: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196

Query: 312  NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
            +  P   R  ++Y+I+    E+    F    +T  L++  P++ +   K    ++A    
Sbjct: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248

Query: 372  GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
               L +F+   +E+L  D N+  P F+   Y   I E  P           T  ++++A 
Sbjct: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297

Query: 430  DKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
            D+D    +D    +    +D +  F +   G T  ++ +Q +D E QQ +   + A D  
Sbjct: 2298 DQDSGRNRDVSYQIVEDGSDVSKFFQI--NGSTGEMSTVQELDYEAQQHFHVKVRAMD-- 2353

Query: 488  QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
             + +P      +V + V D NDN P F +  Y+  V      G  V+++ A+D D     
Sbjct: 2354 -KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTS 2412

Query: 543  EITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
             + Y IL G Q   F IN ++G+I++    +  +  +Y L V A+D         +   V
Sbjct: 2413 RLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPV 2467

Query: 602  YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQ 658
            YI     N  S P F Q +Y  E++E   VG  +++L A D++     +I Y I N    
Sbjct: 2468 YINTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLAS 2526

Query: 659  RVFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPV 716
              F+++    I TL K LDRE ST+R I I + A DG     +  TV I++TD NDN P 
Sbjct: 2527 EKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQ 2584

Query: 717  F--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA 774
            F    Y     S V +++   V QV A D D G N  V YS+   + +  +     +   
Sbjct: 2585 FKASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGV 2642

Query: 775  VK-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
            VK       L  +  D++   + A DG     +S + + ++V+    + P F+   YT  
Sbjct: 2643 VKVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFS 2699

Query: 828  VEENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 884
              E+LP G+ I     + A+D  + + V            F+L P TG + + + +D+E+
Sbjct: 2700 APEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759

Query: 885  FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
                +      V A  +  T    + +V + V D+ND  PVF    YK ++  +   GT 
Sbjct: 2760 TKLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTS 2815

Query: 945  ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
            +  V A D D       +V YR+          +F ++ +SG + T   L+ E    +  
Sbjct: 2816 VIQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHF 2873

Query: 1005 VVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA-- 1060
             VVA+D G+ + +SS A V++ +    +  PRF  EEYR   V E +  G +V  +    
Sbjct: 2874 HVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLD 2932

Query: 1061 ---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVV 1115
               +  N+ +   I  G+    FGI+ +     ++    LD E    Y+LRV A   +  
Sbjct: 2933 ADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF- 2991

Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
                       +  V I + D N++ P   +  Y G V ED      +L+V ATD DT  
Sbjct: 2992 ---------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDT 3042

Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
             + + Y L  P    G   F ++ +TG + T       R+  F     ATD  G G S +
Sbjct: 3043 NAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQ 3096

Query: 1236 ADVLVSV 1242
            AD+ + V
Sbjct: 3097 ADITLHV 3103



 Score =  266 bits (681), Expect = 1e-70
 Identities = 304/1145 (26%), Positives = 493/1145 (43%), Gaps = 119/1145 (10%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V I   + N  SP F+   Y A + E   VGT +      D  A D D GP G I+Y I 
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521

Query: 193  YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                +  +++ F I     G I   ++L+ E+ T   + I+   R       R    T+ 
Sbjct: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
            + + D +D  P F            +   Y  +I       + N    +P IQ +  D +
Sbjct: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613

Query: 313  IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
                +D   + YS+    PED  +    ++P T  + + + +    +Q  D  IKA QD 
Sbjct: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666

Query: 372  GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
            G P   +   + ++++ +    P F+ P Y     E  P G+ I         ++ VA  
Sbjct: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717

Query: 431  KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
                  +DP ++  +   T       VF++   TG+ +   + +P+D E  + Y   + A
Sbjct: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769

Query: 484  --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
                       V VNIQV D NDN P F    Y   +  +M  G SVIQ+TA+D D G +
Sbjct: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829

Query: 542  GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
            G+++Y +      +    F I+  +G IT    ++    +TY   V A D+    +  +S
Sbjct: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888

Query: 598  ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
               V + +   N+ +P RF    Y   + E    G ++  L+  D     +   +T  I 
Sbjct: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947

Query: 654  NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
             GDP   F +S+      +   K LDRE T +Y+L +TASDG+    ++ TV I V DVN
Sbjct: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005

Query: 712  DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
            DN+P     L       +     F+ +V ATD D   N Q+ YSL G   + F++  + G
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065

Query: 770  SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
             + T   L+RE +D + LV  ATDG      + +TL ++  D++DN+P F  S   V V 
Sbjct: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123

Query: 830  ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
            +N    T +  + A+D D GAN       P+  +  F++   TG + L + L        
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179

Query: 889  EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
            +A +   V A D+   +P   + TVTV V  + DY PVF    +   V  DA  GT +  
Sbjct: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239

Query: 948  VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
            +       PG  A +  YRV           F ++  +G +    +L+ E +  + L + 
Sbjct: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292

Query: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
                    +S   TV + +    E  P+F Q+ Y    V E A  G ++  +SA      
Sbjct: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351

Query: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
            +N  I YS++ GN+   F I+   G + V   LD E  +SY L+++A        +   P
Sbjct: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRA-------TDSGQP 3404

Query: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAY 1181
                   + I++ D N++PP F +  Y   V E++ + + VL++  +D D+  N    ++
Sbjct: 3405 PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSF 3464

Query: 1182 RLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
            R     I +G  G     T  G + TA       + +++ Q+ A+D     LS    V V
Sbjct: 3465 R-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRV 3519

Query: 1241 SVVNQ 1245
             V  Q
Sbjct: 3520 HVTEQ 3524



 Score =  266 bits (679), Expect = 2e-70
 Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)

Query: 137  VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
            V+D NDN+P F    Y  T++E T VGTTI      +    D D   NG++ Y +     
Sbjct: 810  VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860

Query: 197  DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
             PT   +      LTG +V+   L+ E + RY + ++A D+      +  + T L + + 
Sbjct: 861  SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916

Query: 257  DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
            D +D  P    C+   N               L+ PE+L P  V   + A D D  + P 
Sbjct: 917  DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957

Query: 317  SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
             +   +L     GT       F +   T  L L   ++ +    ++L + A  D G PL 
Sbjct: 958  GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009

Query: 377  AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
                 H+E++    +EN   P+F    +QG + E++P G  +           IV   +D
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058

Query: 433  IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
             +   D EL  FL   T +   +    T  +  L P+DRE    Y  ++ A D   V  S
Sbjct: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118

Query: 491  EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
                V I+V DANDN P   +  +   +  D   G SV+QL A D D  S G++T+ I  
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178

Query: 551  G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
            G   G F+I+  TGL++ A  ++      + L V   DN  P+ +  S   V + +L  N
Sbjct: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236

Query: 610  NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
            + +PP F   ++++ + E +       +  L A+D +      +TY+IE+ D +  F++ 
Sbjct: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294

Query: 665  ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
              TG+++        + +  IL I A+D G+P  +++  ++I  +      + P+     
Sbjct: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352

Query: 722  PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
              + +V+E +  N  VG +       G  G   +++  G+ +  F I  + GSI  A  L
Sbjct: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408

Query: 778  NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
            +   R  Y L V  TDG+     +T      + +I+ + P F  + Y V V ++   G  
Sbjct: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466

Query: 838  ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
            +L+++A D D G ++ Y I   + P     F L P +G L  +  LD  + P Q  ++T 
Sbjct: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525

Query: 895  LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
            +V   +I   +      VT+ V+D N +PP F++  Y+  V      GT +  V A DAD
Sbjct: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583

Query: 955  PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
              G+ A  V Y    +        F +    G +     L++       L V A D G P
Sbjct: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638

Query: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
                 ATV I+ ++P +   P F++ EY    + E    G+ + ++SA + ++ + Y + 
Sbjct: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695

Query: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
             GN++  F +N+ +G+I     LD+E  +SY L+++  ++     ++          V +
Sbjct: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746

Query: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
            +I DEN++ P+F K  ++G +SE A +++ ++        + A+D D    S++ Y+++ 
Sbjct: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806

Query: 1186 P 1186
            P
Sbjct: 1807 P 1807



 Score =  260 bits (665), Expect = 7e-69
 Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)

Query: 113  SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
            S  + +Q   K +       V + + D+ND  P F   SY  T++E  P+ + I      
Sbjct: 114  SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171

Query: 173  DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
               ATD D G N +  Y         T ++ F I    +G + +  +LN   + ++ + +
Sbjct: 172  ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221

Query: 233  QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
             A DR + ++E              G+  G +    V V               P LR P
Sbjct: 222  LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253

Query: 293  EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
              +  ++VTPP          +  D N    S        ++ G P  + +    + R+ 
Sbjct: 254  PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310

Query: 346  ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
            E SL+  + +N  ++   F+L ++A   +G +      G H+        S  F    Y+
Sbjct: 311  EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368

Query: 402  GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
              + E +P G+ +         +R+     +++    P    +   LN  T + T T+  
Sbjct: 369  VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420

Query: 459  ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
                      +D  ++  Y   I    G   +   +V I ++D N++ P F   SYD  +
Sbjct: 421  ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467

Query: 519  YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
              ++ PG SV+ +TA D D G NG +TY I       F I+   G+I+ +  ++  ++ R
Sbjct: 468  DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527

Query: 578  TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
             Y   V+A+D   P  R   + +++++ L   N + P F ++  +  I +   VG  ++ 
Sbjct: 528  IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585

Query: 638  LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
            + A D  E  ++ Y I +G+    F+L+  +G+++L +    L       Y L ITASDG
Sbjct: 586  MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645

Query: 694  RPDGTSTATVNIVVT--------------------------------------------- 708
            + +  S  T+NI V                                              
Sbjct: 646  K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704

Query: 709  -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
              +N   P F+ + P+++ V+E    N  + ++ ATDPDAG NG++ Y +  GN    F 
Sbjct: 705  YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764

Query: 765  IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
            I    G +  A  L+ E  ++Y L V   D     + S   L + V D +DN+P F    
Sbjct: 765  IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824

Query: 824  YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
            Y + + E+   GTTI ++  KD D   N  V Y + SP  K  F+LHP TGEL +   LD
Sbjct: 825  YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882

Query: 882  YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
             E+    E      VEA D    G     +  + + ++D+ND  P       +  V  D 
Sbjct: 883  RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938

Query: 940  VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
              GT +T  + + +DP   PA  VRY + D         F V+  +G +I    L+ E  
Sbjct: 939  PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992

Query: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
              + L + A D G P+   +   V+++V      LHP     F  +      V E +  G
Sbjct: 993  AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048

Query: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
            T V V++A    + ++  + Y + +G     F IN  TG+I    PLD E  + Y L V 
Sbjct: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108

Query: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
            A D   V L        S+  +VYIE+ D N++PP   +  +   + EDA + TSVL++ 
Sbjct: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160

Query: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
            A D D+ +   + +      I  G     F++   TGL+ TA       +     +V   
Sbjct: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215

Query: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
            D+    L   + V+V +++  D   I S+
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244



 Score =  257 bits (657), Expect = 6e-68
 Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)

Query: 115  VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
            V  V+  +  +G+     V ++V D NDN PTF    Y  +++E  P  T +        
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295

Query: 175  GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
             A+D D G N  + Y I  +  D +    F+I    TG +   + L+YE +  + V ++A
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351

Query: 235  NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
             D+    +   T  T + V+V D +D  P F            R   Y+A + EL T   
Sbjct: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396

Query: 295  LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
            L        +QAID D       D   + Y IL G  +   R F ++  +  +S+     
Sbjct: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443

Query: 355  RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
            +     ++L + A         A   ++I   + N  SP F    Y+  + E+A VG  +
Sbjct: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500

Query: 415  SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
             D         ++A+DKD       +  +     +  F++   G    +  LQ +DRE  
Sbjct: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548

Query: 474  -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
             ++     + A DG        V I + D NDN P F    Y V + +++     VIQ+ 
Sbjct: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608

Query: 533  AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
            A DADEG N ++TY +      +    IN  TG++ +   +  +  +T    ++A D  P
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668

Query: 591  PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
            P    NS+  V ++V+ P   S P+F + +Y+    E +  G+ +  ++A   + D + Y
Sbjct: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724

Query: 651  AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
            ++  G     +   VF+L   TG++ + K +D EST  Y + + A      D  S  +VN
Sbjct: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784

Query: 705  IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
            I V DVNDN PVF  DPY   L  N+ V        V QV A D D G +GQV Y L   
Sbjct: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839

Query: 757  --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
               N + LF I S +G I T  +L+ E    Y   VVA D G      S   + + + D 
Sbjct: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899

Query: 813  DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
            +DN+P F +  Y   V EN   G  +  ++  D D+      V+  I   +    F +  
Sbjct: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959

Query: 870  FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
               E  +S  ++L      D+E +  +L+      G     + TV + V D+ND  P  S
Sbjct: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012

Query: 928  KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
            + +Y G V  D   G  I  V A D D      +++ Y +        A  F+++  +G 
Sbjct: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066

Query: 988  VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
            + T   L+ E   +F LV  A D G     +  T+ +  ++    PRF    +    V +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124

Query: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
              T  T V V+ A       N  +VYS+   + E  F I+  TGVI +  PL    +   
Sbjct: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183

Query: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
             L V+A  L   +        S    V + +    ++ PVF    +   V EDA   T V
Sbjct: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237

Query: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
            L++    +     +   YR ++   ++G+  F ++  TG++   A L       YF    
Sbjct: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288

Query: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
            ++ +   K  S  +DV   +VN  D+
Sbjct: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314



 Score =  253 bits (646), Expect = 1e-66
 Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)

Query: 141  NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
            N  +P F+ H      V E  P+ T +         ATD D G NG++ YVI     D  
Sbjct: 708  NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758

Query: 200  SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
                F+I L  TG + +   L+YE    Y + +   D       ++++   LTV+V D +
Sbjct: 759  EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814

Query: 260  DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
            D  P F             P  YQ  I E     E+   I     +  D +       D 
Sbjct: 815  DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852

Query: 320  PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
              + Y++L  T +     F +HP T EL +   ++R+   ++ L ++A  +   GH L +
Sbjct: 853  GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907

Query: 378  FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
               L I + D N+ SP       +  + E  P G  ++                   D  
Sbjct: 908  VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950

Query: 438  DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
            DP+L       ++ ++     F V    +T  L L + +D E +  Y  S+ A DG   +
Sbjct: 951  DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008

Query: 488  QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
                   V + V+D N+N   P F    +   V  +   G  VI + A D D G +GE+ 
Sbjct: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068

Query: 546  YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            Y +  G     F IN+ TG+I     ++      Y LTV A D    +   +S+  VYIE
Sbjct: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126

Query: 605  VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
            V   N+ +PP+  Q ++   I E   VG  +L L A D +  S   +T+ I +G+    F
Sbjct: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185

Query: 662  NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
             +   TG+L+  + LDRE+ D +IL +T  D G P   ST+ V + + DVNDN P+    
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245

Query: 717  -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
             F+  LP  LS V       V ++ A+D D G+NG+V YS+ + +        +  + S+
Sbjct: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302

Query: 769  GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
             S +TA        +Y  L + ATD    P  +++ L I+ +     S +   F  + Y+
Sbjct: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355

Query: 826  VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
              V E  P      ++ +E +      N+S   +  +    F +   TG + + R LD  
Sbjct: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
                + ++    VE  D  G+          ++ ++N + P F +  Y+  V  D V G 
Sbjct: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465

Query: 944  PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
             +  V A D D        + Y +   Q P  AS+F+++  SG ++T  +++L   P+  
Sbjct: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
              L V+  D   P+  +   V I V    LHP   PRFTQ  Y       +A    ++ V
Sbjct: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577

Query: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
             +  A   +N  + YS++ GN E  F IN + G+I +   LD      + L V+A+    
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633

Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
               +   P   + A V I +   +   P+F K  Y   + E   + + +L V A      
Sbjct: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690

Query: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
             Y           ++EG K+G F + +Y+GLI T     + + S ++ ++      G  +
Sbjct: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735

Query: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
            +G    ++ VV+ +D      N P  L    +  ++E    Y
Sbjct: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774



 Score =  237 bits (604), Expect = 8e-62
 Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)

Query: 132  EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
            EV I V D NDN P      +Y ++ E  PVGT++         A D D    G++ + I
Sbjct: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176

Query: 192  QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
                   TS +     ++  +TG +   ++L+ E+K  + + +   D   N      +T+
Sbjct: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226

Query: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
             + V +LD +D  P+F                    +  +R PE L+P+   P  + +  
Sbjct: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269

Query: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
            D +        G+   +     +     F +   T  +S         +    L IKA  
Sbjct: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320

Query: 370  DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
                PL A   LHIE +     S     F    Y   ++E+ PV   +        P   
Sbjct: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380

Query: 424  -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
               I   DKD++                 F + +T  T  + + +P+D   +  Y  ++ 
Sbjct: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421

Query: 483  AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
              DG +     +    + + N + P F E  Y+V V  D  PG  ++++ A+D D+G + 
Sbjct: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480

Query: 543  EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
             + Y I      G+   F ++ ++G++     +++  G + + LTV   D   P +R   
Sbjct: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539

Query: 598  ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
              T+++E     N  PPRF QL Y   + + +  G  LL ++A D +      + Y++  
Sbjct: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596

Query: 655  GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
            G+ +  FN++   GI+TL + LD+ +   + L + A D G P     ATV I V   + +
Sbjct: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656

Query: 714  APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
            AP+F     ++   VE   +  VG     V A  P      +V Y L  GN + +F + S
Sbjct: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707

Query: 768  -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
             +G I T  KL+ E    Y+L +  ++ A     + + + + ++D +DN+P+F  ST+  
Sbjct: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765

Query: 827  LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
             + E  P  + I+        I A D D  AN  + Y+I  PE   FF + P  G L+++
Sbjct: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825

Query: 878  RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
              +DYE+ P    S  F V   D    +   P  A V + V+D+ND PP FS++IY+  +
Sbjct: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881

Query: 936  APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
                  G  +  V A D D      S V Y +         +I  V   +G +     LN
Sbjct: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929

Query: 996  EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
                 + + + +   DG  +   +A VKI L     +  +F Q+ Y       L  +  +
Sbjct: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987

Query: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
            V ++ A    +N ++ Y +++G   D F +    GV+   G   D E + ++ L V+   
Sbjct: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041

Query: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
                + + R P +     V + I+D N++PP F+   Y   + +       + +V ATD+
Sbjct: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097

Query: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
            D G    + Y        E    F ++ Y G I     F     + +  +VIA D     
Sbjct: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152

Query: 1232 LSGKADVLVSVVNQ 1245
            L  + +VLV+V N+
Sbjct: 2153 LQSEEEVLVTVRNK 2166



 Score =  232 bits (592), Expect = 2e-60
 Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)

Query: 354  NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
            +R+     +L ++  +DN  P     GL  + I D N+  P F    Y   I +    G 
Sbjct: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087

Query: 413  TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
             +          ++ A D+D+  T     + F  DYT        G    ++L +P D +
Sbjct: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134

Query: 473  EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
                Y   + A DG    +Q  E V+V ++    N + P F    Y V V  ++     +
Sbjct: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190

Query: 529  IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
            +  T   + EG       +  E L+    DF     TG++T+   ++      +  TV+A
Sbjct: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245

Query: 586  ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
             D A       S     +EVL  + N +PP F QL+Y+  ISE +     ++ L A+D++
Sbjct: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300

Query: 645  GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
                  ++Y I  +  D  + F ++ +TG ++  + LD E+   + + + A D G P  T
Sbjct: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360

Query: 699  STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
                V + V+D+NDN P F  P    N+S +       V +V+A DPD+    ++ Y + 
Sbjct: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419

Query: 757  -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
             GN +  F I S+  I +   L ++  D  Y L V A+DG      +T+ + I   + + 
Sbjct: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476

Query: 815  NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
             SP F    Y   + EN   GT ++ + A D D G    + Y I +      F+++P  G
Sbjct: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535

Query: 873  ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
            +++ L+ LD E     E  I   V A D  G +     TV +I+ D ND PP F    Y 
Sbjct: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591

Query: 933  GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
              +  +  K +P+  V A DAD  G  A  V Y V+         + E+   +G V  + 
Sbjct: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647

Query: 993  NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
            +L           + A D G P  +S   V++ V+     +P+F++  Y      +L  +
Sbjct: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706

Query: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
            G+ +G++ A A    ++YS+V G     N++  F ++  TGVI V  P+D+E+   Y + 
Sbjct: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766

Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
            V A  L+    N  V S      V I++ D N++ PVF+   Y   ++E+  + TSV++V
Sbjct: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819

Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
             A DKDTG    ++YRL   P     E F +++ +G I T           + F V+A  
Sbjct: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878

Query: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
            D+G+   LS +A V VS+ ++ D
Sbjct: 2879 DHGQTIQLSSQALVQVSITDEND 2901



 Score =  223 bits (567), Expect = 2e-57
 Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
            ST + LD +   + H   V+V+ ++K    +    + +V V D NDN P F+   Y A V
Sbjct: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388

Query: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
            +EL   G                          V++    DP S DT  +  L+L+GN  
Sbjct: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422

Query: 216  LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
                     + R+F I  ++      N  ++   ++  + V   D +    +P  +    
Sbjct: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473

Query: 275  RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
             +     +Q  + E    E  N ++ T  I  +  D++  P      I Y+I+     + 
Sbjct: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528

Query: 335  PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
               F ++P   +++ L+ ++R+   +  + IK    +G    AF  + I + DEN+  P 
Sbjct: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584

Query: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
            F    Y            +I  +++  SP+ I  L  D ++ ++ ++   +N    V  V
Sbjct: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633

Query: 455  TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
             +   +T  + +   +   E QT  F I A DG     +  V V +QV+    + P F E
Sbjct: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693

Query: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
              Y      D+  G  +  + AV A +     + Y ++ G        G F ++  TG+I
Sbjct: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749

Query: 566  TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
             +   ++    + Y + V A    N        S+ +V I+V   N+  P  F    Y  
Sbjct: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804

Query: 624  EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
             ++E M VG  ++ + A D++      ++Y + + DP      +F +   +G +T  + L
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863

Query: 677  DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
            D E+   Y   + A D       +S A V + +TD NDNAP F     R   V   E   
Sbjct: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923

Query: 735  FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
             V  +K  D D    N QV  + + G+    F I+  G    I +   L+RE    Y L 
Sbjct: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983

Query: 789  VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
            V A+DG      +++T+ I VLD++DNSP  +   YT  V E++  G  IL++ A D+D 
Sbjct: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040

Query: 849  GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
              N  ++Y +  P   H F L P TGEL+ L +LD E    ++     + +A D  G   
Sbjct: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095

Query: 907  PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
               A +T+ V+D+ND  P F        V  +    TP+  V+A D D      ++V Y 
Sbjct: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151

Query: 967  VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
            + D    +    F ++  +G +     L   P    +L V A D G P+ +S+  TV + 
Sbjct: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207

Query: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
            V+   + +P F   E+    V E A  GT V  +  A +     +   Y +VSGNE+  F
Sbjct: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264

Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
             ++  TG++YVN  LD+ET   Y L ++        +     S S+   V + I D N H
Sbjct: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
             P F +  Y   V E+A +   +L V ATD+D    S + Y LI      G +   F + 
Sbjct: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372

Query: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
               G ++ A      + S +  ++ ATD     L    D+ + V +  D
Sbjct: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421



 Score =  220 bits (560), Expect = 1e-56
 Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)

Query: 135  IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
            I + D NDNSP    E     V E  P GT +         A+D D GP G++ YV+   
Sbjct: 913  ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967

Query: 195  PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
                 ++ TF + LM TG ++L + L++E +  Y + + A+D  + L  R  T   + V 
Sbjct: 968  -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019

Query: 255  VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
            VLD  ++L P      +           +Q  + E  +P     I+V     A D D  +
Sbjct: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063

Query: 314  QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
                    + Y +  GT       F ++  T  +  L P++R+F   + L + A      
Sbjct: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115

Query: 374  PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
            PL +   ++IE+ D N+  P  +   +   I E APVG         TS L++ A D D 
Sbjct: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166

Query: 434  EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
                    ++   +Y   F +    +T  L+  Q +DRE +  +   +T  D  + S   
Sbjct: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224

Query: 492  PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
               V + ++D NDN P F    ++V +   + P     V +L A D DEG NG +TY I 
Sbjct: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284

Query: 550  VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
               +  F I+  TG+++ +       G    LT++A D+  P    ++   ++IE +P P
Sbjct: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340

Query: 609  NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
               S P  F +  YS  + E   V  ++  +    R G    + I  GD    F++ +TT
Sbjct: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399

Query: 668  GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
            G + + + LD      Y L +  +DG    T    V+I ++ ++N + P F         
Sbjct: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457

Query: 727  VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
              +      + +V+A D D G  +   +H S      +LF++  S+G + T  KL+    
Sbjct: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
               + L V+  D  +  + + + + I V D + + P FT   Y   V + +  GT +LQ+
Sbjct: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577

Query: 842  EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
             A D D G N  V Y +     + FF ++   G ++L + LD        A  T  V+A 
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633

Query: 900  DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
            D        +ATV + V   +   P+FSK  Y   +      G+PI  V A       + 
Sbjct: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686

Query: 960  ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
             S V Y + +        +F +   SG + T+  L+ E  + ++L +   +         
Sbjct: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743

Query: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
              V I +      P F +  +        P  S +  K     VI A+      N  +VY
Sbjct: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802

Query: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
             I+       F I+   G + +   +DYE+  S+   V   D    VL   R       A
Sbjct: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856

Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
            +V I ++D N+ PP F ++ Y   +         +L V+A+D+D+  NYS+
Sbjct: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907



 Score =  218 bits (554), Expect = 5e-56
 Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)

Query: 111  IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
            ++ I V   C+ N  V +++   V I V D NDN P F+ + Y A + E  PVGT++   
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817

Query: 170  FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
                  A D D G +GQ+ Y +  +P     ++ F I    +G I   + L+ E    Y 
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872

Query: 230  VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
              + A D  Q +  + ++   + V + D +D  P F                Y+ ++ E 
Sbjct: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918

Query: 290  RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
              P EL   + T      +Q+R +         L    +    D  R          +S 
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968

Query: 350  LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
             + ++R+   K+ L + A         A   + I +LD N+ SP  +   Y G + E   
Sbjct: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025

Query: 410  VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
             G  I         L++ A D D +           P  H F  D         TG    
Sbjct: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066

Query: 463  LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
            LT L  +DRE +  +     A DG   S    + + V D NDN P F      V V+ + 
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126

Query: 523  RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
                 V  + A D D+G+N ++ Y +   A+G F I+ TTG+I +   +++       LT
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186

Query: 583  VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
            V+A+D   P    +++ TV + V+   +  P  F    +S+++ E    G  +L L    
Sbjct: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244

Query: 643  REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
            R G   T Y + +G+ Q  F L   TGIL +  +LD E++ +Y L I  S       S  
Sbjct: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304

Query: 701  ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
             TV + +TDVN++ P F  DPY  R L       NA VG     V ATD D  +N  + Y
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358

Query: 755  SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
            SL   N L   T     G +  A  L+RE    Y L + ATD    P H    +AI+V D
Sbjct: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418

Query: 812  IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
            ++DN P F    Y+  V+EN P G+ +LQ+   D D    G   S+RI        F + 
Sbjct: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478

Query: 869  PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
            P  G L     L   A    +      ++A D    +PP   + +V V V + + Y P  
Sbjct: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531

Query: 927  SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
                    V  D  +G  +  ++A D DP
Sbjct: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560



 Score =  213 bits (542), Expect = 1e-54
 Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)

Query: 130  YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
            + +V +VV   D NDN+P F   ++   ++E  P+ + I    +      A+D D   N 
Sbjct: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798

Query: 186  QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
             + Y I     +P +   F+I P M  G + +   ++YE    +   +  +D+   +   
Sbjct: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852

Query: 245  RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
                  + + V D +D  P F                    I E+     ++P +    +
Sbjct: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894

Query: 305  QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
            +A D+D  +          YSI  G  ++      +HP T  +S+L P      +K  L 
Sbjct: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940

Query: 365  IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
            I+A  D  +   A   + + ++LD++ Q   F    Y   + E            NL   
Sbjct: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984

Query: 424  LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
              +V L        D   +  LN       V   G+ +  T     DRE+Q T+  ++  
Sbjct: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042

Query: 484  FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
             D    Q     +V + + D NDN P F  + Y   +     PGD + Q++A D D G+N
Sbjct: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102

Query: 542  GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
            G +TYE        F I+   G I++    +      Y L V A D   P+ +      V
Sbjct: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161

Query: 602  YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
             +      N+S P F    Y + + E + +   +L+ QA   EG  + Y I   +P  +F
Sbjct: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216

Query: 662  NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
                 TG+LT+   LD ES  +++  + A+D      S ATV ++V DVNDN P F   +
Sbjct: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276

Query: 722  PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
                      A   V Q+ A+D D+G N  V Y +     + +  F+I  S G + T  +
Sbjct: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336

Query: 777  LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
            L+ E + ++ + V A D    P      + + V DI+DN P F    Y   V E    G 
Sbjct: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396

Query: 837  TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
             +L+++A D D    + + Y I S      F ++  +G +S+            ++S   
Sbjct: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452

Query: 895  LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
             V A D     T+P  I T      + N Y P F + +Y+  +A +A+ GT +  + A D
Sbjct: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507

Query: 953  ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
             D    P   + Y + +       SI      +G++ T   L+ E +T  +  + V+A D
Sbjct: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561

Query: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
             G  V  +  TVKI++    +  P+F   EY     S ++    ++ V++  A    N  
Sbjct: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619

Query: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
            + YS+   +  +D   IN +TGV+ V   L   E +T  + ++ Q             P 
Sbjct: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
             ++   V +++  +    P F +  Y     ED    + +  VKA   +D   YS++  R
Sbjct: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728

Query: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
               P  +  K+G F ++  TG+IK      +     ++  V+A
Sbjct: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769



 Score =  200 bits (509), Expect = 8e-51
 Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)

Query: 125  VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
            + T+I H     V   + ++P F    Y+  + E  PVG+ I   +  S      ++ +G
Sbjct: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697

Query: 183  PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
                       N D   S +++      +G I  +K+L++E  + Y + I+ ++ A    
Sbjct: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739

Query: 243  ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
                T   + VD++D +D  PMFL    V    +  PL        +   +  NP +   
Sbjct: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786

Query: 303  PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
             I A D D+          ++Y IL   PE   +FF + P    L+++  ++ +    F 
Sbjct: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837

Query: 363  LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
              +    D G P+   P  A + I + D N+  P F+   Y+  I+     G  +     
Sbjct: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891

Query: 420  LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
                L + A D      +D E++  +    +   VT   +T  +++L P      +  T 
Sbjct: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940

Query: 480  SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
             I A DG+ + +  +V I +    D +  F +  Y   V  +++   +++ L A      
Sbjct: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996

Query: 540  SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
             N  ++Y +L G     ++     L T     +     T+ L V+  DN  P      + 
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056

Query: 600  TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
             V IE +   N +PP+F  L Y   I +    G VL  + ATD + G +     E  +  
Sbjct: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113

Query: 659  RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
              F +    G ++L K  D ++ ++Y L + A DG   GT +  +   ++VT  N + P+
Sbjct: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170

Query: 717  F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
            F  PY    +P N+++        +   +A  P+ G+  ++ Y++     L   T++   
Sbjct: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222

Query: 769  GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
            G +     L+ E +  +   V ATD A+    S  T+ + V D++DN P F+   YT  +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281

Query: 829  EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
             E LPA T ++Q+ A D D G N  VSY+I     +V  FF ++  TGE+S ++ LDYEA
Sbjct: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341

Query: 885  FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
                +      V A D       G   V V V D+ND PP F +  Y+  V+  A  G  
Sbjct: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397

Query: 945  ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
            +  V A   DP     SR+ Y +           F +   SG +I+  NL ++       
Sbjct: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451

Query: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
            + V   DG  V  ++  V I   +  +  P F Q  Y     +ELA +  MVG  VI   
Sbjct: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504

Query: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
            AI++      +I Y+I++    + F IN   G I     LD E  T  V+ ++  + +  
Sbjct: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561

Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
                    +     V I + DEN++PP F+   Y   +  +    + V++V A D D G 
Sbjct: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616

Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
             + + Y   + P    K+   +   TG++K       +      F + A D
Sbjct: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665



 Score =  196 bits (499), Expect = 1e-49
 Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)

Query: 133  VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
            V ++V D N+N   P F    +   V E +P GT +         A D D G +G+++Y 
Sbjct: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070

Query: 191  IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
            ++      T    F I    TG I     L+ E  + Y++ + A DR    +   ++ T 
Sbjct: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122

Query: 251  LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
            + ++V D +D  P     V  P+ ++  P+                       + A D D
Sbjct: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165

Query: 311  RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
                  S +  + ++I  G   +Y  FF +HP T  LS  + ++R+   +  L +    D
Sbjct: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216

Query: 371  NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
            NG P L + + + + ILD N+  P F+   +             + + L+  SP    R+
Sbjct: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266

Query: 427  VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
            VA D D          IED+ +    + L   T V + + T       +L          
Sbjct: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314

Query: 477  YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
               +I A D  Q      V + +       P+   +++D   Y +T M   D V  +  V
Sbjct: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370

Query: 535  DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
             + EG  G   + I  G +  DF I KTTG I IA  ++      Y LTV+  D +    
Sbjct: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426

Query: 594  RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
             R     V+I ++   N   P+F +  Y + + +    G  LL +QA D++ G S+ Y I
Sbjct: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485

Query: 653  ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
                DP    +F L  ++G+L T+GK        ++ L +   D   P   +   V I V
Sbjct: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545

Query: 708  TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
             D N + P F   L    SV +  A    + QV+A D D G+N +VHYSL  GN    F 
Sbjct: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604

Query: 765  ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
            I +  G I  A KL++     + L V A D      H   T+ I V   D ++P+F+ S 
Sbjct: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664

Query: 824  YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
            Y V + E++P G+ IL + A      + V+Y +R       F+++ ++G +S  + LD+E
Sbjct: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
                  +S    +   ++ G     +  V +I  D ND  P+F K  + G ++  A    
Sbjct: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775

Query: 941  ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
                K      ++A D+D      S + Y++ +   P     F+++   G +     ++ 
Sbjct: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830

Query: 997  EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
            E    F+  V   D G PV+ +    ++ ++H  ++    PRF+++ Y    V  +   G
Sbjct: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888

Query: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
              + ++ A+  +  + YSI +GN ++   I+ +TG I V  P
Sbjct: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930



 Score =  179 bits (454), Expect = 2e-44
 Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V++ + D NDN+P F  E Y  +V E +  G  + T  + D    DI +       Y+ +
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948

Query: 193  YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
             +P         +  +   G+   I  RK L+ E   +Y + + A+D       +   + 
Sbjct: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995

Query: 250  TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
            T+ + VLD +D            N+  C  L Y   + E   P      I+      +D 
Sbjct: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040

Query: 310  DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
            D N Q       I YS+      +    F + P T EL+ L  ++R+    F+LV KA  
Sbjct: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089

Query: 370  DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
              G    A   LH+E  D N+ +P F  PS+             + D+  + +P+ +V  
Sbjct: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137

Query: 430  DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
                +      ++   +     F++  T  T  + L +P+    Q     ++ A D    
Sbjct: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195

Query: 487  VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
            +  S    V + V+   D  P F    + V V  D  PG  V+QL  +        +  Y
Sbjct: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253

Query: 547  EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
             ++ G  QG F ++  TG++ +   ++      Y L+++ +  +  +   + + TV + +
Sbjct: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
               N   P +FPQ  YS  + E   VG V+L + ATD +G     ITY++  G+    F 
Sbjct: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370

Query: 663  LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
            +    G L + KALDRE    Y L + A+D G+P       + I V DVNDN P F    
Sbjct: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427

Query: 722  PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
              N S   +E N+ +G    Q+  +DPD+  NG  +    + GN  + FR+T +G + TA
Sbjct: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486

Query: 775  VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
              L+R  +++Y+L + A+D  + P  S  ++ + V +    +P        + V E+   
Sbjct: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546

Query: 835  GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
            G  + +I A D D    ++Y +   E   +HF
Sbjct: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578



 Score =  127 bits (319), Expect = 9e-29
 Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)

Query: 754  YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
            Y +GNF  L RI +  S      LNREVRD Y L++ AT+  +     T  + + +LD +
Sbjct: 87   YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142

Query: 814  DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
            D  P+F+  +Y V + E++P  + I ++ A D DLG N  +          FA+HP +G 
Sbjct: 143  DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202

Query: 874  LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
            +++   L+       E  +  +     I  G     +A + V V+     PP  +  +  
Sbjct: 203  VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260

Query: 933  GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
             +  PD+  GT   TV   DA+  G     V     D    + A       +   +++  
Sbjct: 261  -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318

Query: 993  NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
            ++N  E    F L + A     P   S   ++   L P ++   +F +  YR   +SE +
Sbjct: 319  DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375

Query: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
              G+ V ++       ++ Y +   +E   F +N  TG+I     +D+  R  Y L ++ 
Sbjct: 376  PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435

Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
                        P +++T  V I+I D NNH P+F +  Y G + E+    TSVL V AT
Sbjct: 436  S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483

Query: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
            D+D G    + Y +  P        F ++ Y G+I T+  M +  M+R Y  F+V A+D
Sbjct: 484  DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)

Query: 647  SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
            ++ Y I +GD   VF   E          I T       L+RE  D Y LII A++   +
Sbjct: 68   AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127

Query: 697  GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
              +   V + + D ND  P+F P   R     +    + + +V ATD D G N + +Y+ 
Sbjct: 128  LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187

Query: 757  GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
               + +F I  ++G +  A KLN   R  +EL V+A D    +   +   +LA  V+ ++
Sbjct: 188  NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247

Query: 814  D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
                      S V T       +TY TVLV+ N  +G  +  +E    D G         
Sbjct: 248  PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297

Query: 859  PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
               KHF A+       S  RS ++     ++ +    +  F++              ++ 
Sbjct: 298  ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335

Query: 919  MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
             +   P F  +I    + P  +        +  V   +  PPG     VR     V   +
Sbjct: 336  RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390

Query: 975  PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
            P   + ++  S  V  ++N      T  KL  + F D           P  +S+  V  +
Sbjct: 391  PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448

Query: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
            V      P F +  Y    + E    GT V  ++A       N  + YSI +G +   F 
Sbjct: 449  VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506

Query: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
            I+   G+I  + P+DYE  +  Y  RV+A              +     +++++++ N++
Sbjct: 507  IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560

Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
             P+F++    G + +D  +  S++ + A D D      + Y ++        E F +  +
Sbjct: 561  QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615

Query: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
            +G+I     F N+   + + +  ++ A+D  GK  +    + ++VV     +V V+
Sbjct: 616  SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669


>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score =  221 bits (562), Expect = 6e-57
 Identities = 249/939 (26%), Positives = 395/939 (42%), Gaps = 123/939 (13%)

Query: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
            FH+HP T  +     ++R+    +  V          L A   + I + D N+ SP F +
Sbjct: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169

Query: 398  PSYQGYILESAPVGATI--------SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT 449
             S Q  + E +P G              L  T    +V      +D   P   L      
Sbjct: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229

Query: 450  SVFTVTQTGITR-----YLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDA 502
             + +    G +       L LL+ +DREE   +   I A+DG   + +  + V ++V+D 
Sbjct: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289

Query: 503  NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV----------GA 552
            NDN P F +  Y   V  D +PG  V ++ A D D G NG + Y +            GA
Sbjct: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349

Query: 553  QGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
             GD   F + + +G++ +   ++      + L V+A D    AE   +   V I VL  N
Sbjct: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVRVSIAVLDVN 407

Query: 610  NQSPPRFPQLMYS---LEISEAMRVGAVLLNLQATDREGD------------------SI 648
            +  P      +       +SE  R G  +  +  +D +GD                  SI
Sbjct: 408  DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467

Query: 649  TYAIENGDPQRVFNLSETTGI--LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
            + ++E G+           G+  L +   LDRES D Y L++ A+D G P  ++  T+ +
Sbjct: 468  SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL 527

Query: 706  VVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG-----------INGQVH 753
             V D+ND  P+F        SV E  A    V  V A+D D             +     
Sbjct: 528  RVADLNDQPPLFSQQ-HYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586

Query: 754  YSLGNFNN----------LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
             +LG+  +           F I S +G+I T   L+REV++  EL VVA D    P  +T
Sbjct: 587  CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646

Query: 803  LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI---- 856
              ++I V D++DN P+F    Y   + E+ P G   LQ+ A D D G    + Y +    
Sbjct: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706

Query: 857  RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 916
             S E    F + P  G++ + + +D E  P   A+   LVEA D  G      A V V +
Sbjct: 707  LSYEAPQAFRIDPHDGQICVSQDIDRERDP---ATYDLLVEAKDGGGLSAQ--AFVRVDL 761

Query: 917  KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
            +D+ND  PVF+   Y   ++ +   GT I  V A D D  G+  + V Y +        +
Sbjct: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD-SGIYGT-VAYELIPGNV---S 816

Query: 977  SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSSATVKIL--VLHPGEI 1032
            S+F ++  +G +   + L+   +T   L+V A D G    V+++  T+ I    L P E 
Sbjct: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876

Query: 1033 --PRFTQEEYRPPPVSELATKGTMVGVISA-AAINQS--IVYSIVSGNEEDTFGINNITG 1087
              P++T   Y   P      + + +G + A   +N S  I Y I SG+    F I+   G
Sbjct: 877  ERPKYTFLVYEDVP------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930

Query: 1088 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1147
             I    PLD+ET+   VL VQ        A L      ++ +V I + D N++ P F + 
Sbjct: 931  TIRTRKPLDHETQPVVVLTVQ--------AQLGSAPACSSTEVNITVMDVNDNHPAFLRT 982

Query: 1148 FYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
                 +S+     T++   +A D+D+G   ++ Y +  P
Sbjct: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021



 Score =  200 bits (509), Expect = 8e-51
 Identities = 298/1218 (24%), Positives = 486/1218 (39%), Gaps = 176/1218 (14%)

Query: 125  VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 176
            +G ++  E+R  V D ND+SP F  +S    V+EL+P GT      + D  A        
Sbjct: 147  LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204

Query: 177  -----TDIDDGPNGQIEYVIQY-------NPDDPTSNDTFEIPLMLTGNIVLRKRLNYED 224
                 +D+   P G   + ++Y       +P  P S+   E PL    ++VL +RL+ E+
Sbjct: 205  TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLE-PL----DLVLLRRLDREE 258

Query: 225  KTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQA 284
               + + I+A D  +    RRT   ++ + VLD +D  P+F                Y+A
Sbjct: 259  AAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVF------------EQDEYRA 303

Query: 285  AIPELRTPEELNPIIVTPPIQAIDQD-----------RNIQPPSDRPGILYSILVGTPED 333
            A+      E+  P      ++A D+D           R  Q P    G       G    
Sbjct: 304  AV-----REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG-------GGALG 351

Query: 334  YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
               +F +   +  + +  P++R+      LV++A      P  A   + I +LD N+  P
Sbjct: 352  DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411

Query: 394  ----YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE--------- 440
                 F        + E A  G  ++         R+   D D +  K+ E         
Sbjct: 412  AIHVLFLTEGGVARVSEGARPGDYVA---------RVSVSDADGDWEKEDEATGELGVGL 462

Query: 441  ----LHLFLNDYTSVFTVTQTGI--TRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEP 492
                + L L      F +   G     +L +  P+DRE +  Y   + A D      S  
Sbjct: 463  GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN----------- 541
              + ++V D ND  P F +  Y   V     PG  V+ ++A DADE  +           
Sbjct: 523  ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582

Query: 542  -------GEITYEILVGAQ--GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
                   G +  +++  A+    F I+  +G I+    ++  V     L V A D   P 
Sbjct: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642

Query: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSIT 649
               ++ C V I V    N + P F + +Y+  I+E   VG   L + A+D +      I 
Sbjct: 643  --LSATCLVSITV-DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699

Query: 650  YAIENG----DPQRVFNLSETTGILTLGKALDRE-STDRYILIITASDGRPDGTST-ATV 703
            Y++ +G    +  + F +    G + + + +DRE     Y L++ A DG   G S  A V
Sbjct: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFV 757

Query: 704  NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNN 761
             + + DVNDN PVF+P         E +    +  V ATD D+GI G V Y L  GN ++
Sbjct: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817

Query: 762  LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
            LF I S  G IY  + L+        L+V A DG          + I +         F 
Sbjct: 818  LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877

Query: 821  NSTYTVLVEENLPAGTTILQIEAKD-VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS 879
               YT LV E++P  + I  ++A++ ++    + YRI S ++   F++HP  G +   + 
Sbjct: 878  RPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKP 937

Query: 880  LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPD 938
            LD+E  P     +   V+A    G+ P   +T V + V D+ND  P F +   +  ++  
Sbjct: 938  LDHETQP----VVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991

Query: 939  AVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
               GT +    AED D    GL    +RY +   Q      +F ++   G +    +L  
Sbjct: 992  TPPGTALYLARAEDRDSGRNGL----IRYSIASPQ----PGVFAIDRALGVLFLNGSLGA 1043

Query: 997  EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE---------EYRPPPVSE 1047
                   L + A D G    ++   + +++      P +T E         E   P    
Sbjct: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103

Query: 1048 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
            L T+   +G   AA+    + YS+    +   FGI   TG IY+    DYE+  +Y  RV
Sbjct: 1104 LQTQAHPLGPQRAAS---PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160

Query: 1108 QADSLE-VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
             A   E   L N+       +  V + + DEN++ P F        V E       + ++
Sbjct: 1161 FAWIPEDGFLQNV-------STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKI 1213

Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
             A D D+G    + Y L    + +GK  F +   TG +   +      R + +  V+ TD
Sbjct: 1214 TAIDMDSGKNGQLLYFL----LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268

Query: 1227 DYGKGLSGKADVLVSVVN 1244
                  +    V VSV +
Sbjct: 1269 RGSPPRNATMAVYVSVTD 1286



 Score =  189 bits (479), Expect = 3e-47
 Identities = 209/782 (26%), Positives = 316/782 (40%), Gaps = 79/782 (10%)

Query: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
            ST R LDR+    +   VV        +       V I V D NDN P F  + Y AT+ 
Sbjct: 616  STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673

Query: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
            E  PVG            A+D D G  G IEY +        +   F I     G I + 
Sbjct: 674  EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH-DGQICVS 727

Query: 218  KRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
            + ++ E D   Y ++++A D         +    + VD+ D +D  P+F P   V +  D
Sbjct: 728  QDIDRERDPATYDLLVEAKDGGG-----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782

Query: 277  CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
                             E  P      + A DQD  I        + Y ++   P +   
Sbjct: 783  -----------------ETQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSS 817

Query: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
             F +   T  + L  P++        L++ A+   G      A + I I         F 
Sbjct: 818  LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877

Query: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-T 455
             P Y   + E  P            SP+  V   + +  ++     +   D    F++  
Sbjct: 878  RPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927

Query: 456  QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTFPEISY 514
            + G  R     +P+D E Q     ++ A  G   +     VNI VMD NDN P F   S 
Sbjct: 928  RLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSD 984

Query: 515  DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
            ++ +     PG ++    A D D G NG I Y I     G F I++  G++ +   +   
Sbjct: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAG 1044

Query: 575  VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGA 633
              R   LT++A D     +    + TV IE       SP   F  L+Y +E+SE++    
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMT 1101

Query: 634  VLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689
             +L  QA      R    + Y++E      +F +   TG + L +  D EST  Y   + 
Sbjct: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161

Query: 690  A---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATD 743
            A    DG     ST TV + V D NDN+P F   L   L +  EE+      +G++ A D
Sbjct: 1162 AWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGKITAID 1217

Query: 744  PDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
             D+G NGQ+ Y L +    F++  N G +   V L+RE R ++E+ V+ TD    PR++T
Sbjct: 1218 MDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNAT 1277

Query: 803  LTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI 856
            + + + V DI+DN P F          V V E  P    +  + AKD D G  A V+Y +
Sbjct: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337

Query: 857  RS 858
             S
Sbjct: 1338 SS 1339



 Score =  184 bits (468), Expect = 5e-46
 Identities = 268/1131 (23%), Positives = 458/1131 (40%), Gaps = 159/1131 (14%)

Query: 133  VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
            V + V D NDN P F+ + Y A V E    G  +         ATD D GPNG + Y ++
Sbjct: 282  VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336

Query: 193  YNP-------DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
                           +  +     L+G + + + L+ E +  + ++++A D      E  
Sbjct: 337  ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA---EPE 393

Query: 246  TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTP 302
              T  +++ VLD                  D RP  +   + E    R  E   P     
Sbjct: 394  VATVRVSIAVLD----------------VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437

Query: 303  PIQAIDQDRNIQPPSDRPGILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPV 353
             +   D D + +   +  G L       SI   L G   D+       P    L +  P+
Sbjct: 438  RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497

Query: 354  NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 413
            +R+    ++L++ A      PL     L + + D N+Q P F+   Y+  + E+A  G  
Sbjct: 498  DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557

Query: 414  I-----SDS--------------LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
            +     SD+              + L++P  + +L   +  T +      ++  +   + 
Sbjct: 558  VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617

Query: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEI 512
             +T           +DRE Q+     + A D  +   S   +V+I V D NDN P F   
Sbjct: 618  IRT-----------LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666

Query: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITI 567
             Y+  +      G   +Q+TA DAD G  G I Y +  G     A   F I+   G I +
Sbjct: 667  VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726

Query: 568  APGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEI 625
            +  ++      TY L V+A D    + +       ++ V L   N + P F    Y   I
Sbjct: 727  SQDIDRERDPATYDLLVEAKDGGGLSAQ------AFVRVDLEDVNDNHPVFNPSTYVTSI 780

Query: 626  SEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 682
            S+  + G  ++N+ ATD++     ++ Y +  G+   +F +  TTGI+ L   L    + 
Sbjct: 781  SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840

Query: 683  RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--N 733
               L+++A DG   G  TA +N  VT       +F   L       P+   +V E+   +
Sbjct: 841  TLSLMVSAQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPED 892

Query: 734  AFVGQVKATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVV 790
            + +G VKA +P    +  + Y  S G+    F I    G+I T   L+ E +    L V 
Sbjct: 893  SPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951

Query: 791  ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
            A  G+  P  S+  + I V+D++DN P F  ++  + + +  P GT +    A+D D G 
Sbjct: 952  AQLGSA-PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010

Query: 851  N--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
            N  + Y I SP+    FA+    G L L  SL       ++  +T  + A D  G  P  
Sbjct: 1011 NGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQA 1064

Query: 909  IATVTVIVKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVR 964
               V  +V +  ++ P   F   +Y+  V+      +P+T +    A P  P   AS +R
Sbjct: 1065 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLR 1121

Query: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATV 1022
            Y ++       +++F +   +G +  R   + E T  +   V A+  +DG  + + S TV
Sbjct: 1122 YSLEP---SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTV 1177

Query: 1023 KILVLHPGE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
             + V    +  P F  +      E  P P   +   G +  +   +  N  ++Y ++S  
Sbjct: 1178 IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDG 1234

Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
            +   F +N  TG +     LD E R  +        + V++ +   P ++ T  VY+ + 
Sbjct: 1235 K--FFKMNPNTGELINWVALDREHRGHH-------EMTVLVTDRGSPPRNATMAVYVSVT 1285

Query: 1136 DENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1181
            D N++ P F      K+ ++  V E   +   V  V A D D GN + + Y
Sbjct: 1286 DINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335



 Score =  147 bits (372), Expect = 6e-35
 Identities = 185/746 (24%), Positives = 315/746 (42%), Gaps = 122/746 (16%)

Query: 631  VGAVLLNLQATDREGDSITYAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILI 687
            VG +   L A  ++  S  +  E+ D   +   F++   TGI+   + LDRE  D Y  +
Sbjct: 83   VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFV 142

Query: 688  ITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDA 746
                 G     +   V I V DVND++P F    L  ++S +     AF   V A DPDA
Sbjct: 143  AATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPV-AHDPDA 196

Query: 747  GINGQVHYSLGNFNNL----------FRITSNGSIYTAV-----------------KLNR 779
            G+     Y+L   ++L           R  + G + + +                 +L+R
Sbjct: 197  GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDR 256

Query: 780  EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
            E    + L + A DG    R   L++ ++VLD +DN PVF    Y   V E+   G  + 
Sbjct: 257  EEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVC 316

Query: 840  QIEAKDVDLGAN--VSYRIRSPEV------------KHFFALHPFTGELSLLRSLDYEAF 885
            ++ A D DLG N  V Y +R+ +V              +FA+   +G + + R LD EA 
Sbjct: 317  RVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREA- 375

Query: 886  PDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP----VFSKRIYKGMVAPDA 939
               +A    +VEA D  G   P +AT  V++ V D+ND  P    +F        V+  A
Sbjct: 376  ---QAWHQLVVEARD--GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430

Query: 940  VKGTPITTVYAEDADPP-------------GLPASRVRYRVDDVQFPY------PASIFE 980
              G  +  V   DAD               GL    +   ++  +  +      P  +F 
Sbjct: 431  RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVF- 489

Query: 981  VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1040
                   +     L+ E   +++L++VA D G P +S+  T+ + V    + P    +++
Sbjct: 490  ------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543

Query: 1041 RPPPVSELATKGTMVGVISAAAINQS------IVYSIVS-------GNEED--------- 1078
                VSE A  GT+V  +SA+  +++      + Y++V        G+ +          
Sbjct: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603

Query: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
             +F I++ +G I     LD E +       +A  L+VV  +L  P  S T  V I + D 
Sbjct: 604  PSFAIDSESGAISTIRTLDREVQ-------EAVELKVVAQDLGEPPLSATCLVSITVDDV 656

Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK-EGKEGFV 1196
            N++ P+F ++ Y   ++E A +    L+V A+D D+G Y  + Y L    +  E  + F 
Sbjct: 657  NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716

Query: 1197 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS-NV 1255
            ++ + G I  +    +  R    + ++     G GLS +A V V + +  D   + + + 
Sbjct: 717  IDPHDGQICVSQDI-DRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPST 775

Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPG 1281
              T +  + +  TEI++    +Q  G
Sbjct: 776  YVTSISDETQPGTEIINVLATDQDSG 801


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  206 bits (525), Expect = 1e-52
 Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)

Query: 463  LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
            L + Q +DRE++ TY   I   DG   Q+S   I+ + V D NDN P F E   +V++  
Sbjct: 204  LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263

Query: 521  DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 576
            +   G SVIQL A DAD GSN EI Y    ++    +  F +N TTGLIT+   ++    
Sbjct: 264  NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323

Query: 577  RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
              + +TV A+D ++ PA    +I    +   PPN         +  ++ +SE   V   +
Sbjct: 324  AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383

Query: 636  LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 692
              +  +D++ D    +   IE   P  +  + +   +L     LD E T  +   I ASD
Sbjct: 384  ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443

Query: 693  -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 749
             G+P    TA V + + D NDN P+F+ P +   LSV E      ++  + ATD D+G N
Sbjct: 444  SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501

Query: 750  GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
              + Y LG   + F +     + TA ++ +RE ++ +   V A D    P  S   + + 
Sbjct: 502  ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561

Query: 809  VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 868
            VLD +DNSP FT++ +   V ENLP  +T+  I   D D G N +  +        F L 
Sbjct: 562  VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621

Query: 869  PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
            P++G +    S D E    Q++S TF V+A D  G  PP    A VT+ V D+ND  PV 
Sbjct: 622  PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675

Query: 927  ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
                S   +K +V   A+ G+ +  V+A D D  G+ A  ++Y +          +F ++
Sbjct: 676  ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729

Query: 983  EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
              +G +            + +LVV   D G P
Sbjct: 730  PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761



 Score =  203 bits (516), Expect = 1e-51
 Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)

Query: 618  QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 668
            +L+Y++  E+ E + +G +     + ++ A      S+ Y + +  GD   V   S T  
Sbjct: 25   ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84

Query: 669  ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
            I T    +DRE                +  ++I+       D      + I+V D NDNA
Sbjct: 85   IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139

Query: 715  PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 769
            P+F P    N+S+ E    N+      ATDPD G NG  HY L N  ++F +    T  G
Sbjct: 140  PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198

Query: 770  SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
              +  +     L+RE +D Y + +   DG    + ST  L + V D++DN PVF      
Sbjct: 199  EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258

Query: 826  VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 880
            V + EN P GT+++Q+ A D D+G+N   R       +P  K  FAL+  TG +++ RSL
Sbjct: 259  VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318

Query: 881  DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 940
            D E    + A     V A D  G+  P  ATVT+ V D+ND PP    R    +++P  +
Sbjct: 319  DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367

Query: 941  KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 990
             G    TVY  + DP     + +     D          ++   P  +  V ++   + T
Sbjct: 368  NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423

Query: 991  RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1050
               L+ E T  F   +VA D G+P ++ +A V++ +    + P    +      VSE   
Sbjct: 424  SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483

Query: 1051 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
            +G  +  ISA    +  N  IVY +  G     F ++  TGV+  +   D E +  ++  
Sbjct: 484  RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541

Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
            V A        +   P   + A V + + DEN++ P F    +   VSE+   +++V  +
Sbjct: 542  VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594

Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
              TD D G    +   ++        + FV++ Y+G+IK+ + F   ++S + F V ATD
Sbjct: 595  TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649

Query: 1227 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1277
                  S  A V ++V++  D   +V + PP+    K+  L+ I    V E
Sbjct: 650  GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699



 Score =  182 bits (461), Expect = 3e-45
 Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)

Query: 349 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 406
           L+   N D  QK   V+K + +D G P  +    L + + D N+  P F     + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263

Query: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 461
           +APVG         TS +++ A D DI    + E+        +     +F +  T  T 
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310

Query: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 515
            +T+ + +DREE   +  ++ A DG        V I V D NDN P          I+  
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370

Query: 516 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 567
           VY+         +  +T  D D   NG        E+ + +       +++ +T+ L+  
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429

Query: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
               E      ++  + A+D+  P+  + ++  V +E     N +PP F Q +  L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480

Query: 628 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
             R G  L  + ATD + G +     + G     F+L   TG+LT  +  DRE  +R+I 
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540

Query: 687 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 740
            +TA D G P   S A V + V D NDN+P F       ++  NL        + VG + 
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595

Query: 741 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
            TD DAG N  V  S+ N N+ F +   +G I + V  +RE +  Y   V ATDG   PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655

Query: 800 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 853
            ST  + I V+D++DNSPV     +N+++ ++    +P G+ + ++ A DVD G N  + 
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714

Query: 854 YRIRSPEVKHFFALHPFTGELSL 876
           Y I S   K  F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737



 Score =  167 bits (424), Expect = 6e-41
 Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)

Query: 495  VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 553
            + I V D NDN P FP    ++ +  +          +A D D G NG   YE+L G   
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 554  -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
             G  I+    G     + +   ++     TY + ++  D   P +   +I  V +  +  
Sbjct: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245

Query: 609  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 662
             N + P F +    + I E   VG  ++ L ATD +  S      I  A      +R+F 
Sbjct: 246  -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304

Query: 663  LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 721
            L+ TTG++T+ ++LDRE T  + + + ASDG     + ATV I VTDVNDN P  D  Y+
Sbjct: 305  LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363

Query: 722  --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 773
              P N +V   E    N  +  +  +D D  +NG+V   +     F+      +   + T
Sbjct: 364  ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423

Query: 774  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
            +  L+ E    +   +VA+D      + T  + +K+ D +DN P+F      + V EN  
Sbjct: 424  SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483

Query: 834  AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
             G  +  I A D D G N     +      FF L   TG L+  R  D E   +QE  I 
Sbjct: 484  RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539

Query: 894  FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
            F V A D  GT P    A V V V D ND  P F+   ++  V+ +  K + +  +   D
Sbjct: 540  FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598

Query: 953  ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
            AD     A  +    D+  F        ++  SG + + V+ + E  + +   V A D G
Sbjct: 599  ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 1013 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1063
            +P  SS+A V I V+      P  I   +   ++  P+S  A  G++V  + A  +    
Sbjct: 652  QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVI 1089
            N  + Y+IVSGN +  F I+ +TG I
Sbjct: 710  NAELKYTIVSGNNKGLFRIDPVTGNI 735



 Score =  141 bits (356), Expect = 5e-33
 Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)

Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
           +++I+V+D NDN+P F        +N   P  T I + F   + ATD D G NG   Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181

Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
             N       D  E P       +++++ L+ E K  Y + I+  D       ++++T  
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237

Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
           L V V D +D  P+F                 +    E+  PE  N  + T  IQ    D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278

Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
            +I   ++   I Y           R F ++  T  +++   ++R+      + + A   
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333

Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
           +G   PA A + I + D N+  P   +     YI+  +P+  T+     D +N T    I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386

Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
              DKD +   + ++  F+                 L     +D E  + ++F I A D 
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444

Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
            + S  +  +V +++ D NDN P F +   ++ V  + R G  +  ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504

Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            Y++   A   F +++ TG++T +   +      +  TV A DN  P     S   V + 
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561

Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
           VL  N+ S P+F    +   +SE +   + +  +  TD    E  ++T +I N +    F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618

Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 719
            L   +G++    + DRE    Y   + A+D G+P  +STA V I V DVNDN+P V  P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678

Query: 720 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 765
               +  +V   A   + V +V A D D G+N ++ Y++  GN   LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728



 Score =  102 bits (253), Expect = 4e-21
 Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)

Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
           +P   Q A+  ++  +E  NP I   P+  +    N     +R G+  + +  T ED  +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500

Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
                        FF +  +T  L+     +R+  ++F   + A  +   PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560

Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
            +LDEN+ SP FT   +Q ++ E+ P  +T+           I   D D  + K   L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611

Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
            LND  +      +G+ +        DRE+Q +YTF + A DG Q   S    V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667

Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
            NDN+P     P  +    V     PG  V ++ AVD D G N E+ Y I+ G  +G F 
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727

Query: 558 INKTTGLITI 567
           I+  TG IT+
Sbjct: 728 IDPVTGNITL 737



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)

Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
           V + V D NDNSP F H  +   V+E  P  +T+     G    TD D G N  +   I 
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612

Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                   ND F +    +G I      + E ++ Y   ++A D  Q     R++T  +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662

Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
           ++V+D +D  P+    V+ P +     L   +AIP            V   + A+D D  
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708

Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
           +        + Y+I+ G  +     F + P T  ++L E                     
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739

Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
            P P   GLH   + I D        T+     Y+ ++A   + I D +  T       L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796

Query: 430 DKDIEDTKDP 439
           D++I D+  P
Sbjct: 797 DRNIGDSSQP 806


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  206 bits (525), Expect = 1e-52
 Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)

Query: 463  LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
            L + Q +DRE++ TY   I   DG   Q+S   I+ + V D NDN P F E   +V++  
Sbjct: 204  LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263

Query: 521  DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 576
            +   G SVIQL A DAD GSN EI Y    ++    +  F +N TTGLIT+   ++    
Sbjct: 264  NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323

Query: 577  RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
              + +TV A+D ++ PA    +I    +   PPN         +  ++ +SE   V   +
Sbjct: 324  AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383

Query: 636  LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 692
              +  +D++ D    +   IE   P  +  + +   +L     LD E T  +   I ASD
Sbjct: 384  ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443

Query: 693  -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 749
             G+P    TA V + + D NDN P+F+ P +   LSV E      ++  + ATD D+G N
Sbjct: 444  SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501

Query: 750  GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
              + Y LG   + F +     + TA ++ +RE ++ +   V A D    P  S   + + 
Sbjct: 502  ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561

Query: 809  VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 868
            VLD +DNSP FT++ +   V ENLP  +T+  I   D D G N +  +        F L 
Sbjct: 562  VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621

Query: 869  PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
            P++G +    S D E    Q++S TF V+A D  G  PP    A VT+ V D+ND  PV 
Sbjct: 622  PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675

Query: 927  ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
                S   +K +V   A+ G+ +  V+A D D  G+ A  ++Y +          +F ++
Sbjct: 676  ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729

Query: 983  EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
              +G +            + +LVV   D G P
Sbjct: 730  PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761



 Score =  203 bits (516), Expect = 1e-51
 Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)

Query: 618  QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 668
            +L+Y++  E+ E + +G +     + ++ A      S+ Y + +  GD   V   S T  
Sbjct: 25   ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84

Query: 669  ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
            I T    +DRE                +  ++I+       D      + I+V D NDNA
Sbjct: 85   IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139

Query: 715  PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 769
            P+F P    N+S+ E    N+      ATDPD G NG  HY L N  ++F +    T  G
Sbjct: 140  PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198

Query: 770  SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
              +  +     L+RE +D Y + +   DG    + ST  L + V D++DN PVF      
Sbjct: 199  EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258

Query: 826  VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 880
            V + EN P GT+++Q+ A D D+G+N   R       +P  K  FAL+  TG +++ RSL
Sbjct: 259  VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318

Query: 881  DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 940
            D E    + A     V A D  G+  P  ATVT+ V D+ND PP    R    +++P  +
Sbjct: 319  DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367

Query: 941  KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 990
             G    TVY  + DP     + +     D          ++   P  +  V ++   + T
Sbjct: 368  NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423

Query: 991  RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1050
               L+ E T  F   +VA D G+P ++ +A V++ +    + P    +      VSE   
Sbjct: 424  SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483

Query: 1051 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
            +G  +  ISA    +  N  IVY +  G     F ++  TGV+  +   D E +  ++  
Sbjct: 484  RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541

Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
            V A        +   P   + A V + + DEN++ P F    +   VSE+   +++V  +
Sbjct: 542  VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594

Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
              TD D G    +   ++        + FV++ Y+G+IK+ + F   ++S + F V ATD
Sbjct: 595  TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649

Query: 1227 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1277
                  S  A V ++V++  D   +V + PP+    K+  L+ I    V E
Sbjct: 650  GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699



 Score =  182 bits (461), Expect = 3e-45
 Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)

Query: 349 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 406
           L+   N D  QK   V+K + +D G P  +    L + + D N+  P F     + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263

Query: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 461
           +APVG         TS +++ A D DI    + E+        +     +F +  T  T 
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310

Query: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 515
            +T+ + +DREE   +  ++ A DG        V I V D NDN P          I+  
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370

Query: 516 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 567
           VY+         +  +T  D D   NG        E+ + +       +++ +T+ L+  
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429

Query: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
               E      ++  + A+D+  P+  + ++  V +E     N +PP F Q +  L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480

Query: 628 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
             R G  L  + ATD + G +     + G     F+L   TG+LT  +  DRE  +R+I 
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540

Query: 687 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 740
            +TA D G P   S A V + V D NDN+P F       ++  NL        + VG + 
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595

Query: 741 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
            TD DAG N  V  S+ N N+ F +   +G I + V  +RE +  Y   V ATDG   PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655

Query: 800 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 853
            ST  + I V+D++DNSPV     +N+++ ++    +P G+ + ++ A DVD G N  + 
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714

Query: 854 YRIRSPEVKHFFALHPFTGELSL 876
           Y I S   K  F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737



 Score =  167 bits (424), Expect = 6e-41
 Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)

Query: 495  VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 553
            + I V D NDN P FP    ++ +  +          +A D D G NG   YE+L G   
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 554  -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
             G  I+    G     + +   ++     TY + ++  D   P +   +I  V +  +  
Sbjct: 188  FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245

Query: 609  NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 662
             N + P F +    + I E   VG  ++ L ATD +  S      I  A      +R+F 
Sbjct: 246  -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304

Query: 663  LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 721
            L+ TTG++T+ ++LDRE T  + + + ASDG     + ATV I VTDVNDN P  D  Y+
Sbjct: 305  LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363

Query: 722  --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 773
              P N +V   E    N  +  +  +D D  +NG+V   +     F+      +   + T
Sbjct: 364  ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423

Query: 774  AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
            +  L+ E    +   +VA+D      + T  + +K+ D +DN P+F      + V EN  
Sbjct: 424  SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483

Query: 834  AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
             G  +  I A D D G N     +      FF L   TG L+  R  D E   +QE  I 
Sbjct: 484  RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539

Query: 894  FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
            F V A D  GT P    A V V V D ND  P F+   ++  V+ +  K + +  +   D
Sbjct: 540  FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598

Query: 953  ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
            AD     A  +    D+  F        ++  SG + + V+ + E  + +   V A D G
Sbjct: 599  ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 1013 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1063
            +P  SS+A V I V+      P  I   +   ++  P+S  A  G++V  + A  +    
Sbjct: 652  QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVI 1089
            N  + Y+IVSGN +  F I+ +TG I
Sbjct: 710  NAELKYTIVSGNNKGLFRIDPVTGNI 735



 Score =  141 bits (356), Expect = 5e-33
 Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)

Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
           +++I+V+D NDN+P F        +N   P  T I + F   + ATD D G NG   Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181

Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
             N       D  E P       +++++ L+ E K  Y + I+  D       ++++T  
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237

Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
           L V V D +D  P+F                 +    E+  PE  N  + T  IQ    D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278

Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
            +I   ++   I Y           R F ++  T  +++   ++R+      + + A   
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333

Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
           +G   PA A + I + D N+  P   +     YI+  +P+  T+     D +N T    I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386

Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
              DKD +   + ++  F+                 L     +D E  + ++F I A D 
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444

Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
            + S  +  +V +++ D NDN P F +   ++ V  + R G  +  ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504

Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
            Y++   A   F +++ TG++T +   +      +  TV A DN  P     S   V + 
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561

Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
           VL  N+ S P+F    +   +SE +   + +  +  TD    E  ++T +I N +    F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618

Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 719
            L   +G++    + DRE    Y   + A+D G+P  +STA V I V DVNDN+P V  P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678

Query: 720 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 765
               +  +V   A   + V +V A D D G+N ++ Y++  GN   LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728



 Score =  102 bits (253), Expect = 4e-21
 Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)

Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
           +P   Q A+  ++  +E  NP I   P+  +    N     +R G+  + +  T ED  +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500

Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
                        FF +  +T  L+     +R+  ++F   + A  +   PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560

Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
            +LDEN+ SP FT   +Q ++ E+ P  +T+           I   D D  + K   L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611

Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
            LND  +      +G+ +        DRE+Q +YTF + A DG Q   S    V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667

Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
            NDN+P     P  +    V     PG  V ++ AVD D G N E+ Y I+ G  +G F 
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727

Query: 558 INKTTGLITI 567
           I+  TG IT+
Sbjct: 728 IDPVTGNITL 737



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)

Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
           V + V D NDNSP F H  +   V+E  P  +T+     G    TD D G N  +   I 
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612

Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
                   ND F +    +G I      + E ++ Y   ++A D  Q     R++T  +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662

Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
           ++V+D +D  P+    V+ P +     L   +AIP            V   + A+D D  
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708

Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
           +        + Y+I+ G  +     F + P T  ++L E                     
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739

Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
            P P   GLH   + I D        T+     Y+ ++A   + I D +  T       L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796

Query: 430 DKDIEDTKDP 439
           D++I D+  P
Sbjct: 797 DRNIGDSSQP 806


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  198 bits (504), Expect = 3e-50
 Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)

Query: 245  RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
            R  TT     +L G  +  + L CV+  +    +  T +  IPE        ++LN  +I
Sbjct: 25   RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84

Query: 300  VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
                +    Q + +    D P      L+   ED    F    R     L   + RD H 
Sbjct: 85   PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138

Query: 360  KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
             +++ +    D    L     L   I D N+ +P F        I  S P  + I+    
Sbjct: 139  FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191

Query: 420  LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
            L +    V  D  I   ++ EL    N +   V    +      L + + +DREE+ TY 
Sbjct: 192  LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248

Query: 479  FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
              +   DG   Q S   I+ + V D NDN P F E   +V +  +   G SV QL A DA
Sbjct: 249  MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308

Query: 537  DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
            D G N +I +    LV   A+  F +N TTGLITI   ++      + L V A+D     
Sbjct: 309  DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368

Query: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
             R      V + V   N+  P    + + +     + +SE + +   +  +  TD++ D 
Sbjct: 369  AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424

Query: 648  ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
               +T   ++  P R+  +     +L     LD EST  Y + + A+D G+P    +A +
Sbjct: 425  NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484

Query: 704  NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
             I V D NDNAPVF       +S+ E  +    + +V ATD D+G N +++Y LG +   
Sbjct: 485  FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543

Query: 762  LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
             F +     + T VK L+RE  D Y   ++A D  V P  S +T+ + ++D +DNSPVFT
Sbjct: 544  EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603

Query: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
            ++ Y   V ENLP   T+  I   D D G N +  +   +    F +   TG +    S 
Sbjct: 604  HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663

Query: 881  DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
            D E    ++ S TF V+A D         A VT+ V D+ND  PVF    Y     +V P
Sbjct: 664  DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719

Query: 938  DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
                GT +  V A D D  G+ A  VRY +          +F +++++G +      +  
Sbjct: 720  STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774

Query: 998  PTTIFKLVVVAFDDGEP 1014
               + +++V A D G+P
Sbjct: 775  DLGLHRVLVKANDLGQP 791



 Score =  187 bits (474), Expect = 1e-46
 Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            V +   + D NDN P FP    ++ +  +           AVD D G NG   YE L+ +
Sbjct: 155  VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213

Query: 553  QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
            Q  F   +I    G     + +   ++     TY + V+  D   P  +R+S   + + V
Sbjct: 214  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
               N+  P  F +    + I E   VG  +  L ATD    E   I ++  N      +R
Sbjct: 272  TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
            +F+L+ TTG++T+ + LDRE T  + L++ ASDG     + A V + VTDVNDN P  D 
Sbjct: 331  LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389

Query: 719  PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
             Y+  P N +VV  E    N  +  +  TD DA  NG+V     +         F+N F 
Sbjct: 390  RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449

Query: 765  ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
            + +      A  L+ E    Y + ++A D    P + +  L IKV D +DN+PVFT S  
Sbjct: 450  LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
            TV + EN   G  ++++ A D D G N     +  P+    F+L   TG L++++ LD E
Sbjct: 504  TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
                +E    F + A D    +PP  + VTV V   D ND  PVF+   YK  V  +  +
Sbjct: 564  ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
               +  +   D D     A  +    ++  F        ++  +G +   ++ + E    
Sbjct: 618  HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
            +   V A D G    SSSA V I V+   +      +P +    E   P  +       +
Sbjct: 671  YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
            + V +   +N  + YSIV GN  D F I+  TG I +    D      + + V+A+ L  
Sbjct: 731  IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790

Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                  VV+ NL V      A +  E+  ++   PV
Sbjct: 791  PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826



 Score =  172 bits (436), Expect = 2e-42
 Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)

Query: 624  EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
            EI E + +G +L +L  +     S+T  ++       GD   +    +T  I T G  +D
Sbjct: 65   EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124

Query: 678  REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
            RE        D +          PD       +  ++ D+NDNAP+F P    N+S+ E 
Sbjct: 125  REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183

Query: 731  EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
             A N+      A DPD GING  +Y L    N+F +    T  G     +    +L+RE 
Sbjct: 184  SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
            +D Y + V   DG    R ST  L + V D +DN PVF  +   V + EN P GT++ Q+
Sbjct: 244  KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303

Query: 842  EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
             A D D+G N           S   +  F L+  TG +++   LD E  P+ +     LV
Sbjct: 304  HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359

Query: 897  EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
             A D  G + P  A V V V D+ND  P    R     V    V  +  P+ T  A    
Sbjct: 360  LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417

Query: 951  --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
              +DAD  G       + +     P  ++ F +E  +        L+ E T  + + ++A
Sbjct: 418  TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
             D G+P ++ SA + I V    +  P FTQ  +    + E  + G  +  +SA    +  
Sbjct: 471  ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
            N  I Y ++  +    F ++  TG++ V   LD E    Y+  + A        +  VP 
Sbjct: 530  NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
             ++   V++ I D+N++ PVF    Y   V E+     +V  +  TD D G+ S +   +
Sbjct: 582  LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641

Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
            +     +  + F +++ TG+I+  + F   ++  + F V A D      S  A V ++VV
Sbjct: 642  L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696

Query: 1244 NQLDMQVIVSNVPP 1257
            +  D + +   VPP
Sbjct: 697  DVNDNKPVFI-VPP 709



 Score =  168 bits (426), Expect = 4e-41
 Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)

Query: 98  STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
           +TG  +DR+      P + H    V+V  +  ++  ++  ++R ++ D NDN+P F    
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172

Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
               +N   P  + I + ++    A D D G NG   Y +     +    D  E P    
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229

Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
              ++++K L+ E+K  Y + ++  D       +R++T  L V V D +D  P+F     
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281

Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                  +    + +IPE       N  + T   Q    D +I    +   I +S     
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324

Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
                R FH++  T  +++ EP++R+      L++ A   +G  +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382

Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
             P   +     YI+        +S+++ L + + ++ + DKD +            D+ 
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435

Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
             F +      ++ L     +D E  + Y   + A D  +   ++  ++ I+V D NDN 
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495

Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
           P F +    V +  +  PG  +++++A DAD G N EI Y +   A  +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555

Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
           +   ++      Y  T+ A DN  P    N   TV++ ++  N+ SP  F    Y   + 
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612

Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
           E + R G V L        GD+    +   D    F +   TG++    + DRE  + Y 
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672

Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
             + A D GR   +S+A V I V DVNDN PVF   PY     L +        V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732

Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
            D D G+N +V YS+  GN  +LF I    G+I    K +             TD  +H 
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779

Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
                 + +K  D+     +F+     + V E++   T I ++  K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  198 bits (504), Expect = 3e-50
 Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)

Query: 245  RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
            R  TT     +L G  +  + L CV+  +    +  T +  IPE        ++LN  +I
Sbjct: 25   RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84

Query: 300  VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
                +    Q + +    D P      L+   ED    F    R     L   + RD H 
Sbjct: 85   PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138

Query: 360  KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
             +++ +    D    L     L   I D N+ +P F        I  S P  + I+    
Sbjct: 139  FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191

Query: 420  LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
            L +    V  D  I   ++ EL    N +   V    +      L + + +DREE+ TY 
Sbjct: 192  LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248

Query: 479  FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
              +   DG   Q S   I+ + V D NDN P F E   +V +  +   G SV QL A DA
Sbjct: 249  MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308

Query: 537  DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
            D G N +I +    LV   A+  F +N TTGLITI   ++      + L V A+D     
Sbjct: 309  DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368

Query: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
             R      V + V   N+  P    + + +     + +SE + +   +  +  TD++ D 
Sbjct: 369  AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424

Query: 648  ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
               +T   ++  P R+  +     +L     LD EST  Y + + A+D G+P    +A +
Sbjct: 425  NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484

Query: 704  NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
             I V D NDNAPVF       +S+ E  +    + +V ATD D+G N +++Y LG +   
Sbjct: 485  FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543

Query: 762  LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
             F +     + T VK L+RE  D Y   ++A D  V P  S +T+ + ++D +DNSPVFT
Sbjct: 544  EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603

Query: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
            ++ Y   V ENLP   T+  I   D D G N +  +   +    F +   TG +    S 
Sbjct: 604  HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663

Query: 881  DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
            D E    ++ S TF V+A D         A VT+ V D+ND  PVF    Y     +V P
Sbjct: 664  DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719

Query: 938  DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
                GT +  V A D D  G+ A  VRY +          +F +++++G +      +  
Sbjct: 720  STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774

Query: 998  PTTIFKLVVVAFDDGEP 1014
               + +++V A D G+P
Sbjct: 775  DLGLHRVLVKANDLGQP 791



 Score =  187 bits (474), Expect = 1e-46
 Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            V +   + D NDN P FP    ++ +  +           AVD D G NG   YE L+ +
Sbjct: 155  VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213

Query: 553  QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
            Q  F   +I    G     + +   ++     TY + V+  D   P  +R+S   + + V
Sbjct: 214  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
               N+  P  F +    + I E   VG  +  L ATD    E   I ++  N      +R
Sbjct: 272  TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
            +F+L+ TTG++T+ + LDRE T  + L++ ASDG     + A V + VTDVNDN P  D 
Sbjct: 331  LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389

Query: 719  PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
             Y+  P N +VV  E    N  +  +  TD DA  NG+V     +         F+N F 
Sbjct: 390  RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449

Query: 765  ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
            + +      A  L+ E    Y + ++A D    P + +  L IKV D +DN+PVFT S  
Sbjct: 450  LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
            TV + EN   G  ++++ A D D G N     +  P+    F+L   TG L++++ LD E
Sbjct: 504  TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
                +E    F + A D    +PP  + VTV V   D ND  PVF+   YK  V  +  +
Sbjct: 564  ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
               +  +   D D     A  +    ++  F        ++  +G +   ++ + E    
Sbjct: 618  HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
            +   V A D G    SSSA V I V+   +      +P +    E   P  +       +
Sbjct: 671  YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
            + V +   +N  + YSIV GN  D F I+  TG I +    D      + + V+A+ L  
Sbjct: 731  IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790

Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                  VV+ NL V      A +  E+  ++   PV
Sbjct: 791  PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826



 Score =  172 bits (436), Expect = 2e-42
 Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)

Query: 624  EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
            EI E + +G +L +L  +     S+T  ++       GD   +    +T  I T G  +D
Sbjct: 65   EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124

Query: 678  REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
            RE        D +          PD       +  ++ D+NDNAP+F P    N+S+ E 
Sbjct: 125  REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183

Query: 731  EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
             A N+      A DPD GING  +Y L    N+F +    T  G     +    +L+RE 
Sbjct: 184  SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
            +D Y + V   DG    R ST  L + V D +DN PVF  +   V + EN P GT++ Q+
Sbjct: 244  KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303

Query: 842  EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
             A D D+G N           S   +  F L+  TG +++   LD E  P+ +     LV
Sbjct: 304  HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359

Query: 897  EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
             A D  G + P  A V V V D+ND  P    R     V    V  +  P+ T  A    
Sbjct: 360  LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417

Query: 951  --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
              +DAD  G       + +     P  ++ F +E  +        L+ E T  + + ++A
Sbjct: 418  TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
             D G+P ++ SA + I V    +  P FTQ  +    + E  + G  +  +SA    +  
Sbjct: 471  ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
            N  I Y ++  +    F ++  TG++ V   LD E    Y+  + A        +  VP 
Sbjct: 530  NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
             ++   V++ I D+N++ PVF    Y   V E+     +V  +  TD D G+ S +   +
Sbjct: 582  LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641

Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
            +     +  + F +++ TG+I+  + F   ++  + F V A D      S  A V ++VV
Sbjct: 642  L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696

Query: 1244 NQLDMQVIVSNVPP 1257
            +  D + +   VPP
Sbjct: 697  DVNDNKPVFI-VPP 709



 Score =  168 bits (426), Expect = 4e-41
 Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)

Query: 98  STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
           +TG  +DR+      P + H    V+V  +  ++  ++  ++R ++ D NDN+P F    
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172

Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
               +N   P  + I + ++    A D D G NG   Y +     +    D  E P    
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229

Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
              ++++K L+ E+K  Y + ++  D       +R++T  L V V D +D  P+F     
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281

Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                  +    + +IPE       N  + T   Q    D +I    +   I +S     
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324

Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
                R FH++  T  +++ EP++R+      L++ A   +G  +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382

Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
             P   +     YI+        +S+++ L + + ++ + DKD +            D+ 
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435

Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
             F +      ++ L     +D E  + Y   + A D  +   ++  ++ I+V D NDN 
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495

Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
           P F +    V +  +  PG  +++++A DAD G N EI Y +   A  +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555

Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
           +   ++      Y  T+ A DN  P    N   TV++ ++  N+ SP  F    Y   + 
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612

Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
           E + R G V L        GD+    +   D    F +   TG++    + DRE  + Y 
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672

Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
             + A D GR   +S+A V I V DVNDN PVF   PY     L +        V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732

Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
            D D G+N +V YS+  GN  +LF I    G+I    K +             TD  +H 
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779

Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
                 + +K  D+     +F+     + V E++   T I ++  K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  198 bits (504), Expect = 3e-50
 Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)

Query: 245  RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
            R  TT     +L G  +  + L CV+  +    +  T +  IPE        ++LN  +I
Sbjct: 14   RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 73

Query: 300  VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
                +    Q + +    D P      L+   ED    F    R     L   + RD H 
Sbjct: 74   PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 127

Query: 360  KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
             +++ +    D    L     L   I D N+ +P F        I  S P  + I+    
Sbjct: 128  FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 180

Query: 420  LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
            L +    V  D  I   ++ EL    N +   V    +      L + + +DREE+ TY 
Sbjct: 181  LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 237

Query: 479  FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
              +   DG   Q S   I+ + V D NDN P F E   +V +  +   G SV QL A DA
Sbjct: 238  MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 297

Query: 537  DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
            D G N +I +    LV   A+  F +N TTGLITI   ++      + L V A+D     
Sbjct: 298  DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 357

Query: 593  ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
             R      V + V   N+  P    + + +     + +SE + +   +  +  TD++ D 
Sbjct: 358  AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413

Query: 648  ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
               +T   ++  P R+  +     +L     LD EST  Y + + A+D G+P    +A +
Sbjct: 414  NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 473

Query: 704  NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
             I V D NDNAPVF       +S+ E  +    + +V ATD D+G N +++Y LG +   
Sbjct: 474  FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 532

Query: 762  LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
             F +     + T VK L+RE  D Y   ++A D  V P  S +T+ + ++D +DNSPVFT
Sbjct: 533  EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 592

Query: 821  NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
            ++ Y   V ENLP   T+  I   D D G N +  +   +    F +   TG +    S 
Sbjct: 593  HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 652

Query: 881  DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
            D E    ++ S TF V+A D         A VT+ V D+ND  PVF    Y     +V P
Sbjct: 653  DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 708

Query: 938  DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
                GT +  V A D D  G+ A  VRY +          +F +++++G +      +  
Sbjct: 709  STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 763

Query: 998  PTTIFKLVVVAFDDGEP 1014
               + +++V A D G+P
Sbjct: 764  DLGLHRVLVKANDLGQP 780



 Score =  187 bits (474), Expect = 1e-46
 Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            V +   + D NDN P FP    ++ +  +           AVD D G NG   YE L+ +
Sbjct: 144  VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 202

Query: 553  QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
            Q  F   +I    G     + +   ++     TY + V+  D   P  +R+S   + + V
Sbjct: 203  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 260

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
               N+  P  F +    + I E   VG  +  L ATD    E   I ++  N      +R
Sbjct: 261  TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
            +F+L+ TTG++T+ + LDRE T  + L++ ASDG     + A V + VTDVNDN P  D 
Sbjct: 320  LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 378

Query: 719  PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
             Y+  P N +VV  E    N  +  +  TD DA  NG+V     +         F+N F 
Sbjct: 379  RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438

Query: 765  ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
            + +      A  L+ E    Y + ++A D    P + +  L IKV D +DN+PVFT S  
Sbjct: 439  LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
            TV + EN   G  ++++ A D D G N     +  P+    F+L   TG L++++ LD E
Sbjct: 493  TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
                +E    F + A D    +PP  + VTV V   D ND  PVF+   YK  V  +  +
Sbjct: 553  ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 606

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
               +  +   D D     A  +    ++  F        ++  +G +   ++ + E    
Sbjct: 607  HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 659

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
            +   V A D G    SSSA V I V+   +      +P +    E   P  +       +
Sbjct: 660  YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
            + V +   +N  + YSIV GN  D F I+  TG I +    D      + + V+A+ L  
Sbjct: 720  IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 779

Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                  VV+ NL V      A +  E+  ++   PV
Sbjct: 780  PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815



 Score =  172 bits (436), Expect = 2e-42
 Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)

Query: 624  EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
            EI E + +G +L +L  +     S+T  ++       GD   +    +T  I T G  +D
Sbjct: 54   EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 113

Query: 678  REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
            RE        D +          PD       +  ++ D+NDNAP+F P    N+S+ E 
Sbjct: 114  REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 172

Query: 731  EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
             A N+      A DPD GING  +Y L    N+F +    T  G     +    +L+RE 
Sbjct: 173  SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
            +D Y + V   DG    R ST  L + V D +DN PVF  +   V + EN P GT++ Q+
Sbjct: 233  KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 292

Query: 842  EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
             A D D+G N           S   +  F L+  TG +++   LD E  P+ +     LV
Sbjct: 293  HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 348

Query: 897  EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
             A D  G + P  A V V V D+ND  P    R     V    V  +  P+ T  A    
Sbjct: 349  LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406

Query: 951  --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
              +DAD  G       + +     P  ++ F +E  +        L+ E T  + + ++A
Sbjct: 407  TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 459

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
             D G+P ++ SA + I V    +  P FTQ  +    + E  + G  +  +SA    +  
Sbjct: 460  ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 518

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
            N  I Y ++  +    F ++  TG++ V   LD E    Y+  + A        +  VP 
Sbjct: 519  NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 570

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
             ++   V++ I D+N++ PVF    Y   V E+     +V  +  TD D G+ S +   +
Sbjct: 571  LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630

Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
            +     +  + F +++ TG+I+  + F   ++  + F V A D      S  A V ++VV
Sbjct: 631  L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685

Query: 1244 NQLDMQVIVSNVPP 1257
            +  D + +   VPP
Sbjct: 686  DVNDNKPVFI-VPP 698



 Score =  168 bits (426), Expect = 4e-41
 Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)

Query: 98  STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
           +TG  +DR+      P + H    V+V  +  ++  ++  ++R ++ D NDN+P F    
Sbjct: 107 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 161

Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
               +N   P  + I + ++    A D D G NG   Y +     +    D  E P    
Sbjct: 162 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 218

Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
              ++++K L+ E+K  Y + ++  D       +R++T  L V V D +D  P+F     
Sbjct: 219 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 270

Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                  +    + +IPE       N  + T   Q    D +I    +   I +S     
Sbjct: 271 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 313

Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
                R FH++  T  +++ EP++R+      L++ A   +G  +PA A + + + D N+
Sbjct: 314 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 371

Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
             P   +     YI+        +S+++ L + + ++ + DKD +            D+ 
Sbjct: 372 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 424

Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
             F +      ++ L     +D E  + Y   + A D  +   ++  ++ I+V D NDN 
Sbjct: 425 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484

Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
           P F +    V +  +  PG  +++++A DAD G N EI Y +   A  +F +++ TG++T
Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 544

Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
           +   ++      Y  T+ A DN  P    N   TV++ ++  N+ SP  F    Y   + 
Sbjct: 545 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 601

Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
           E + R G V L        GD+    +   D    F +   TG++    + DRE  + Y 
Sbjct: 602 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 661

Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
             + A D GR   +S+A V I V DVNDN PVF   PY     L +        V QV A
Sbjct: 662 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 721

Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
            D D G+N +V YS+  GN  +LF I    G+I    K +             TD  +H 
Sbjct: 722 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 768

Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
                 + +K  D+     +F+     + V E++   T I ++  K ++
Sbjct: 769 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 812


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
            sapiens]
          Length = 1021

 Score =  195 bits (495), Expect = 4e-49
 Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 307
            +D+L G  +  + L CV+  +    +  T +  +PE        ++LN  +I    +   
Sbjct: 1    MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60

Query: 308  DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
             Q + +    D P      L+   ED    F    R     L   + RD H  +++ +  
Sbjct: 61   MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114

Query: 368  EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
              D    L     L   I D N+ +P F        I  S P  + I+    L +    V
Sbjct: 115  LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164

Query: 428  ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
              D  I   ++ EL    N +   V    +      L + + +DREE+ TY   +   DG
Sbjct: 165  DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224

Query: 487  --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
               Q S   I+ + V D NDN P F E   +V +  +   G SV QL A DAD G N +I
Sbjct: 225  GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284

Query: 545  TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
             +    LV   A+  F +N TTGLITI   ++      + L V A+D      R      
Sbjct: 285  HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340

Query: 601  VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 652
            V + V   N+  P    + + +     + +SE + +   +  +  TD++ D    +T   
Sbjct: 341  VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400

Query: 653  ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
            ++  P R+  +     +L     LD EST  Y + + A+D G+P    +A + I V D N
Sbjct: 401  DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460

Query: 712  DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 769
            DNAPVF       +S+ E  +    + +V A D D+G N +++Y LG +    F +    
Sbjct: 461  DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519

Query: 770  SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
             + T VK L+RE  D Y   ++A D  V P  S +T+ + ++D +DNSPVFT++ Y   V
Sbjct: 520  GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579

Query: 829  EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
             ENLP   T+  I   D D G N +  +   +    F +   TG +    S D E    +
Sbjct: 580  PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635

Query: 889  EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 944
            + S TF V+A D         A VT+ V D+ND  PVF    S   Y+ +V P    GT 
Sbjct: 636  QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694

Query: 945  ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
            +  V A D D  G+ A  VRY +          +F +++++G +      +     + ++
Sbjct: 695  VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749

Query: 1005 VVVAFDDGEP 1014
            +V A D G+P
Sbjct: 750  LVKANDLGQP 759



 Score =  185 bits (470), Expect = 3e-46
 Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            V +   + D NDN P FP    ++ +  +           AVD D G NG   YE L+ +
Sbjct: 123  VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181

Query: 553  QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
            Q  F   +I    G     + +   ++     TY + V+  D   P  +R+S   + + V
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
               N+  P  F +    + I E   VG  +  L ATD    E   I ++  N      +R
Sbjct: 240  TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
            +F+L+ TTG++T+ + LDRE T  + L++ ASDG     + A V + VTDVNDN P  D 
Sbjct: 299  LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357

Query: 719  PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
             Y+  P N +VV  E    N  +  +  TD DA  NG+V     +         F+N F 
Sbjct: 358  RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417

Query: 765  ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
            +       TA  L+ E    Y + ++A D    P + +  L IKV D +DN+PVFT S  
Sbjct: 418  LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
            TV + EN   G  + ++ A D D G N     +  P+    F+L   TG L++++ LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
                +E    F + A D    +PP  + VTV V   D ND  PVF+   Y   V  +  +
Sbjct: 532  ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
               +  +   D D     A  +    ++  F        ++  +G +   ++ + E    
Sbjct: 586  HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1054
            +   V A D G    SSSA V I V+   +        P     E   P  +       +
Sbjct: 639  YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
            + V +   +N  + YSIV GN  D F I+  TG I +    D      + + V+A+ L  
Sbjct: 699  IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758

Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                  VV+ NL V      A +  E+  ++   PV
Sbjct: 759  PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794



 Score =  174 bits (442), Expect = 5e-43
 Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)

Query: 624  EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
            E+ E + +G +L +L  +     S+T A++       GD   +    +T  I T G  +D
Sbjct: 33   EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92

Query: 678  REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
            RE        D +          PD       +  ++ D+NDNAP+F P    N+S+ E 
Sbjct: 93   REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151

Query: 731  EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
             A N+      A DPD GING  +Y L    N+F +    T  G     +    +L+RE 
Sbjct: 152  SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
            +D Y + V   DG    R ST  L + V D +DN PVF  +   V + EN P GT++ Q+
Sbjct: 212  KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271

Query: 842  EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
             A D D+G N           S   +  F L+  TG +++   LD E  P+ +     LV
Sbjct: 272  HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327

Query: 897  EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
             A D  G + P  A V V V D+ND  P    R     V    V  +  P+ T  A    
Sbjct: 328  LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385

Query: 951  --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
              +DAD  G       + +     P  ++ F +E       T   L+ E T  + + ++A
Sbjct: 386  TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
             D G+P ++ SA + I V    +  P FTQ  +    + E  + G  +  +SA    +  
Sbjct: 439  ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
            N  I Y ++  +    F ++  TG++ V   LD E    Y+  + A        +  VP 
Sbjct: 498  NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
             ++   V++ I D+N++ PVF    Y   V E+     +V  +  TD D G+ S +   +
Sbjct: 550  LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609

Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
            +     +  + F +++ TG+I+  + F   ++  + F V A D      S  A V ++VV
Sbjct: 610  L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664

Query: 1244 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1298
            +  D + +     SN    LV       T +      +   G    V  SI      D F
Sbjct: 665  DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724

Query: 1299 SLEDYT-------KCDLT 1309
            +++  T       KCD+T
Sbjct: 725  AIDQETGNITLMEKCDVT 742



 Score =  163 bits (412), Expect = 1e-39
 Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)

Query: 98  STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
           +TG  +DR+      P + H    V+V  +  ++  ++  ++R ++ D NDN+P F    
Sbjct: 86  TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140

Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
               +N   P  + I + ++    A D D G NG   Y +     +    D  E P    
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197

Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
              ++++K L+ E+K  Y + ++  D       +R++T  L V V D +D  P+F     
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249

Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                  +    + +IPE       N  + T   Q    D +I    +   I +S     
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292

Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
                R FH++  T  +++ EP++R+      L++ A   +G  +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350

Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 443
             P   +     YI+        +S+++ L + + ++ + DKD +         D E+  
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406

Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 501
            L    S   + +T    YL      D E  + Y   + A D  +   ++  ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458

Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
            NDN P F +    V +  +  PG  + +++A+DAD G N +I Y +   A  +F ++  
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518

Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
           TG++T+   ++      Y  T+ A DN  P    N   TV++ ++  N+ SP  F    Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575

Query: 622 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
           +  + E + R G V L        GD+    +   D    F +   TG++    + DRE 
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635

Query: 681 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 735
            + Y   + A D GR   +S+A V I V DVNDN PVF    P N S    +        
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694

Query: 736 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 792
           V QV A D D G+N +V YS+  GN  +LF I    G+I    K +             T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742

Query: 793 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
           D  +H       + +K  D+     +F+     + V E++   T I ++  K  +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  195 bits (495), Expect = 4e-49
 Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)

Query: 253  VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 307
            +D+L G  +  + L CV+  +    +  T +  +PE        ++LN  +I    +   
Sbjct: 1    MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60

Query: 308  DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
             Q + +    D P      L+   ED    F    R     L   + RD H  +++ +  
Sbjct: 61   MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114

Query: 368  EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
              D    L     L   I D N+ +P F        I  S P  + I+    L +    V
Sbjct: 115  LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164

Query: 428  ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
              D  I   ++ EL    N +   V    +      L + + +DREE+ TY   +   DG
Sbjct: 165  DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224

Query: 487  --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
               Q S   I+ + V D NDN P F E   +V +  +   G SV QL A DAD G N +I
Sbjct: 225  GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284

Query: 545  TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
             +    LV   A+  F +N TTGLITI   ++      + L V A+D      R      
Sbjct: 285  HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340

Query: 601  VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 652
            V + V   N+  P    + + +     + +SE + +   +  +  TD++ D    +T   
Sbjct: 341  VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400

Query: 653  ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
            ++  P R+  +     +L     LD EST  Y + + A+D G+P    +A + I V D N
Sbjct: 401  DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460

Query: 712  DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 769
            DNAPVF       +S+ E  +    + +V A D D+G N +++Y LG +    F +    
Sbjct: 461  DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519

Query: 770  SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
             + T VK L+RE  D Y   ++A D  V P  S +T+ + ++D +DNSPVFT++ Y   V
Sbjct: 520  GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579

Query: 829  EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
             ENLP   T+  I   D D G N +  +   +    F +   TG +    S D E    +
Sbjct: 580  PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635

Query: 889  EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 944
            + S TF V+A D         A VT+ V D+ND  PVF    S   Y+ +V P    GT 
Sbjct: 636  QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694

Query: 945  ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
            +  V A D D  G+ A  VRY +          +F +++++G +      +     + ++
Sbjct: 695  VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749

Query: 1005 VVVAFDDGEP 1014
            +V A D G+P
Sbjct: 750  LVKANDLGQP 759



 Score =  185 bits (470), Expect = 3e-46
 Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)

Query: 493  VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
            V +   + D NDN P FP    ++ +  +           AVD D G NG   YE L+ +
Sbjct: 123  VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181

Query: 553  QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
            Q  F   +I    G     + +   ++     TY + V+  D   P  +R+S   + + V
Sbjct: 182  QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239

Query: 606  LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
               N+  P  F +    + I E   VG  +  L ATD    E   I ++  N      +R
Sbjct: 240  TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 660  VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
            +F+L+ TTG++T+ + LDRE T  + L++ ASDG     + A V + VTDVNDN P  D 
Sbjct: 299  LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357

Query: 719  PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
             Y+  P N +VV  E    N  +  +  TD DA  NG+V     +         F+N F 
Sbjct: 358  RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417

Query: 765  ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
            +       TA  L+ E    Y + ++A D    P + +  L IKV D +DN+PVFT S  
Sbjct: 418  LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 825  TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
            TV + EN   G  + ++ A D D G N     +  P+    F+L   TG L++++ LD E
Sbjct: 472  TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531

Query: 884  AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
                +E    F + A D    +PP  + VTV V   D ND  PVF+   Y   V  +  +
Sbjct: 532  ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585

Query: 942  GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
               +  +   D D     A  +    ++  F        ++  +G +   ++ + E    
Sbjct: 586  HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638

Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1054
            +   V A D G    SSSA V I V+   +        P     E   P  +       +
Sbjct: 639  YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698

Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
            + V +   +N  + YSIV GN  D F I+  TG I +    D      + + V+A+ L  
Sbjct: 699  IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758

Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
                  VV+ NL V      A +  E+  ++   PV
Sbjct: 759  PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794



 Score =  174 bits (442), Expect = 5e-43
 Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)

Query: 624  EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
            E+ E + +G +L +L  +     S+T A++       GD   +    +T  I T G  +D
Sbjct: 33   EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92

Query: 678  REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
            RE        D +          PD       +  ++ D+NDNAP+F P    N+S+ E 
Sbjct: 93   REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151

Query: 731  EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
             A N+      A DPD GING  +Y L    N+F +    T  G     +    +L+RE 
Sbjct: 152  SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211

Query: 782  RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
            +D Y + V   DG    R ST  L + V D +DN PVF  +   V + EN P GT++ Q+
Sbjct: 212  KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271

Query: 842  EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
             A D D+G N           S   +  F L+  TG +++   LD E  P+ +     LV
Sbjct: 272  HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327

Query: 897  EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
             A D  G + P  A V V V D+ND  P    R     V    V  +  P+ T  A    
Sbjct: 328  LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385

Query: 951  --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
              +DAD  G       + +     P  ++ F +E       T   L+ E T  + + ++A
Sbjct: 386  TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438

Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
             D G+P ++ SA + I V    +  P FTQ  +    + E  + G  +  +SA    +  
Sbjct: 439  ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
            N  I Y ++  +    F ++  TG++ V   LD E    Y+  + A        +  VP 
Sbjct: 498  NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549

Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
             ++   V++ I D+N++ PVF    Y   V E+     +V  +  TD D G+ S +   +
Sbjct: 550  LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609

Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
            +     +  + F +++ TG+I+  + F   ++  + F V A D      S  A V ++VV
Sbjct: 610  L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664

Query: 1244 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1298
            +  D + +     SN    LV       T +      +   G    V  SI      D F
Sbjct: 665  DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724

Query: 1299 SLEDYT-------KCDLT 1309
            +++  T       KCD+T
Sbjct: 725  AIDQETGNITLMEKCDVT 742



 Score =  163 bits (412), Expect = 1e-39
 Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)

Query: 98  STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
           +TG  +DR+      P + H    V+V  +  ++  ++  ++R ++ D NDN+P F    
Sbjct: 86  TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140

Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
               +N   P  + I + ++    A D D G NG   Y +     +    D  E P    
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197

Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
              ++++K L+ E+K  Y + ++  D       +R++T  L V V D +D  P+F     
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249

Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
                  +    + +IPE       N  + T   Q    D +I    +   I +S     
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292

Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
                R FH++  T  +++ EP++R+      L++ A   +G  +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350

Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 443
             P   +     YI+        +S+++ L + + ++ + DKD +         D E+  
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406

Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 501
            L    S   + +T    YL      D E  + Y   + A D  +   ++  ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458

Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
            NDN P F +    V +  +  PG  + +++A+DAD G N +I Y +   A  +F ++  
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518

Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
           TG++T+   ++      Y  T+ A DN  P    N   TV++ ++  N+ SP  F    Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575

Query: 622 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
           +  + E + R G V L        GD+    +   D    F +   TG++    + DRE 
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635

Query: 681 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 735
            + Y   + A D GR   +S+A V I V DVNDN PVF    P N S    +        
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694

Query: 736 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 792
           V QV A D D G+N +V YS+  GN  +LF I    G+I    K +             T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742

Query: 793 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
           D  +H       + +K  D+     +F+     + V E++   T I ++  K  +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,002,902
Number of Sequences: 37866
Number of extensions: 3416021
Number of successful extensions: 45071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 490
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 24656
Number of HSP's gapped (non-prelim): 7767
length of query: 1677
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1561
effective length of database: 13,855,062
effective search space: 21627751782
effective search space used: 21627751782
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press