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Search of human proteins with 218505787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo
sapiens]
(1790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 3560 0.0
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 2985 0.0
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 2966 0.0
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 2908 0.0
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 2890 0.0
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 2888 0.0
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 2884 0.0
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 2873 0.0
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 2836 0.0
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 2825 0.0
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 2782 0.0
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 1600 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 338 2e-92
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 323 9e-88
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 311 3e-84
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 305 2e-82
gi|16933557 dachsous 1 precursor [Homo sapiens] 290 7e-78
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 290 1e-77
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 277 8e-74
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 271 4e-72
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 266 1e-70
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 265 3e-70
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 224 4e-58
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 206 1e-52
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 206 1e-52
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 196 2e-49
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 196 2e-49
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 196 2e-49
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 192 2e-48
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 192 2e-48
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 3560 bits (9231), Expect = 0.0
Identities = 1790/1790 (100%), Positives = 1790/1790 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500
PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500
Query: 1501 EYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAEPTYTTWKRARIFPMIFKKVRG 1560
EYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAEPTYTTWKRARIFPMIFKKVRG
Sbjct: 1501 EYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAEPTYTTWKRARIFPMIFKKVRG 1560
Query: 1561 LADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESE 1620
LADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESE
Sbjct: 1561 LADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESE 1620
Query: 1621 FSESETTEEESESETPSEEEESSTPESEESESTESEGEKARKNIVLARRRPMVEEVKEVK 1680
FSESETTEEESESETPSEEEESSTPESEESESTESEGEKARKNIVLARRRPMVEEVKEVK
Sbjct: 1621 FSESETTEEESESETPSEEEESSTPESEESESTESEGEKARKNIVLARRRPMVEEVKEVK 1680
Query: 1681 GRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGSAESASVEGGVESE 1740
GRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGSAESASVEGGVESE
Sbjct: 1681 GRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGSAESASVEGGVESE 1740
Query: 1741 EESESGSSSSSSESQSGGPWGYQVPAYDRSKNANQKKSPGANSEGYNTAL 1790
EESESGSSSSSSESQSGGPWGYQVPAYDRSKNANQKKSPGANSEGYNTAL
Sbjct: 1741 EESESGSSSSSSESQSGGPWGYQVPAYDRSKNANQKKSPGANSEGYNTAL 1790
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 2985 bits (7739), Expect = 0.0
Identities = 1502/1518 (98%), Positives = 1505/1518 (99%), Gaps = 7/1518 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 473
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 474 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 533
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 534 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 593
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 594 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 653
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 654 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 713
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 714 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 773
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 834 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 893
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 894 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 953
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 954 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1013
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1014 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1073
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1253
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1254 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1313
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1314 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1373
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1374 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1433
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500
PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE
Sbjct: 1434 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1493
Query: 1501 EYEEEEEEPKKIKKPKVE 1518
EYEEEE K++ K V+
Sbjct: 1494 EYEEEEWARKRMIKLVVD 1511
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 2966 bits (7689), Expect = 0.0
Identities = 1497/1518 (98%), Positives = 1500/1518 (98%), Gaps = 12/1518 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500
PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE
Sbjct: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1488
Query: 1501 EYEEEEEEPKKIKKPKVE 1518
EYEEEE K++ K V+
Sbjct: 1489 EYEEEEWARKRMIKLVVD 1506
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 2908 bits (7538), Expect = 0.0
Identities = 1462/1469 (99%), Positives = 1462/1469 (99%), Gaps = 7/1469 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 473
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 474 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 533
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 534 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 593
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 594 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 653
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 654 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 713
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 714 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 773
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 774 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 834 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 893
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 894 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 953
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 954 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1013
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1014 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1073
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1253
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1254 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1313
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1314 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1373
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1374 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1433
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1434 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1462
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1812 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1840
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 2890 bits (7493), Expect = 0.0
Identities = 1458/1470 (99%), Positives = 1458/1470 (99%), Gaps = 12/1470 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHK 1470
PAPVAAPPPPPPPPPGAHLYEELGDSSMHK
Sbjct: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSMHK 1458
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 2888 bits (7488), Expect = 0.0
Identities = 1457/1469 (99%), Positives = 1457/1469 (99%), Gaps = 12/1469 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1457
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1807 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1835
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 2884 bits (7476), Expect = 0.0
Identities = 1455/1468 (99%), Positives = 1456/1468 (99%), Gaps = 12/1468 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSM 1468
PAPVAAPPPPPPPPPGAHLYEELGDSS+
Sbjct: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSI 1456
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1805 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1833
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 2873 bits (7447), Expect = 0.0
Identities = 1452/1468 (98%), Positives = 1453/1468 (98%), Gaps = 15/1468 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPA
Sbjct: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPA 1425
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSM 1468
PAPVAAPPPPPPPPPGAHLYEELGDSS+
Sbjct: 1426 PAPVAAPPPPPPPPPGAHLYEELGDSSI 1453
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1802 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1830
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 2836 bits (7351), Expect = 0.0
Identities = 1435/1469 (97%), Positives = 1435/1469 (97%), Gaps = 34/1469 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD---------------------------GTI 33
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 34 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 93
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 213
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 214 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 333
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 334 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 393
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 394 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 446
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 447 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 507 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 567 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 626
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 686
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 687 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 746
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 807 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 866
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 867 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 926
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 927 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 987 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1046
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1047 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1167 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1226
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1227 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1286
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1287 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1346
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1347 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1406
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1407 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1435
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1785 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1813
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 2825 bits (7322), Expect = 0.0
Identities = 1432/1469 (97%), Positives = 1432/1469 (97%), Gaps = 37/1469 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD---------------------------GTI 33
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 34 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 93
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 213
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 214 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 333
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 334 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 393
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 394 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 446
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 447 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 507 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 567 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 626
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 686
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 687 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 746
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 807 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 866
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 867 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 926
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 927 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 987 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1046
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1047 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1167 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1226
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1227 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1286
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1287 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1346
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPA
Sbjct: 1347 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPA 1403
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1404 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1432
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1782 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1810
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 2782 bits (7211), Expect = 0.0
Identities = 1415/1468 (96%), Positives = 1416/1468 (96%), Gaps = 52/1468 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDP
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDP------------------------------------- 198
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 199 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 258
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 259 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 318
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 319 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 379 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 432 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 491
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 492 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 551
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 552 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 611
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 612 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 671
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 672 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 731
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
Query: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
Query: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 911
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 912 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
Query: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 972 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1031
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1032 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1091
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1092 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1151
Query: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1152 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1211
Query: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1212 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1271
Query: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1272 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1331
Query: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPA
Sbjct: 1332 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPA 1388
Query: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSM 1468
PAPVAAPPPPPPPPPGAHLYEELGDSS+
Sbjct: 1389 PAPVAAPPPPPPPPPGAHLYEELGDSSI 1416
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1765 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1793
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 1600 bits (4142), Expect = 0.0
Identities = 877/1189 (73%), Positives = 951/1189 (79%), Gaps = 81/1189 (6%)
Query: 349 TAELSLLEPVNRDFHQKFDLVIKAE---QDNGHPLPAFAGLHIEILDENNQSPYFT---- 401
T + L + +N + ++ ++I+A Q+ L +++LD ++ P F
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 402 MPSYQG---YILESAPVGATISDSLN---LTSPLRIVALDKDIEDVPPSGVPTKDPELHL 455
+P+ + ++A + LN +T P++ + D++I+ PPS P L+
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ--PPSDRPGI---LYS 325
Query: 456 FL----NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNI 509
L DY F + T L+LL+PV+R+ Q + I A P ++I
Sbjct: 326 ILVGTPEDYPRFFHMHPR--TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 510 QVMDANDNTPTFPEISYDVYVYTDMRPGDSV---------IQLTAVDAD-EGSNGEITYE 559
+++D N+ +P F SY Y+ G ++ +++ A+D D E + +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 560 ILVGAQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
L F + +T T +T+ V+ +TY ++ A D +E V I+V
Sbjct: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQV 499
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 674
+ N+ +P FP++ Y + + MR G ++ L A D + S ITY I G Q F
Sbjct: 500 MDANDNTPT-FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
Query: 675 LSETTG----------------------------------ILTLGKALDRESTDRYILII 700
+++TTG ILTLGKALDRESTDRYILII
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
Query: 701 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGI 760
TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGI
Sbjct: 618 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGI 677
Query: 761 NGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 820
NGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK
Sbjct: 678 NGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
Query: 821 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 880
VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH
Sbjct: 738 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 797
Query: 881 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 940
PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK
Sbjct: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 857
Query: 941 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000
RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV
Sbjct: 858 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 917
Query: 1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSEL 1060
ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSEL
Sbjct: 918 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSEL 977
Query: 1061 ATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
ATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ
Sbjct: 978 ATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA
Sbjct: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY
Sbjct: 1098 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1157
Query: 1241 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVES 1300
GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVES
Sbjct: 1158 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVES 1217
Query: 1301 IGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEG 1360
IGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEG
Sbjct: 1218 IGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEG 1277
Query: 1361 GRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAE 1420
GRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAE
Sbjct: 1278 GRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAE 1337
Query: 1421 CTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
CTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1338 CTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1386
Score = 1250 bits (3234), Expect = 0.0
Identities = 726/1146 (63%), Positives = 804/1146 (70%), Gaps = 99/1146 (8%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
Query: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
Query: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
Query: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
Query: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
Query: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Query: 601 APPAERRNSI-------------------------------CTVYIEVLPPNNQSPPRFP 629
APPAER I TV I V N+ +P P
Sbjct: 589 APPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDP 648
Query: 630 QLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGK 686
L +L + E A + ++ATD + + Y++ G+ +F ++ I T K
Sbjct: 649 YLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK 705
Query: 687 ALDRESTDRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 745
L+RE D Y L++ A+DG ST T+ I V D++DN+PVF L A
Sbjct: 706 -LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 764
Query: 746 AFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE----LV 800
+ Q++A D D G N + F + G + L+ E E +
Sbjct: 765 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
Query: 801 VVATD--GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 858
V A D G + P +T+T+ +K D++D PVF+ Y +V + GT I + A+D
Sbjct: 825 VEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 882
Query: 859 D----LGANVSYR---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 911
D + V YR ++ P F + +G + +L+ E +V AF
Sbjct: 883 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLVVVAF 938
Query: 912 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 971
D + ATV ++V + P + V+ A KGT + + A A +
Sbjct: 939 DDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AINQSIV 997
Query: 972 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM--- 1028
S V +D F + +G + L+ E T + L V A D E V+
Sbjct: 998 YSIVSGNEEDT--------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANL 1048
Query: 1029 ---SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1085
S S T K+ + EI Q+E PPV + K + GV A + S++ V
Sbjct: 1049 RVPSKSNTAKVYI----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR--VK 1096
Query: 1086 GNEEDT 1091
++DT
Sbjct: 1097 ATDKDT 1102
Score = 31.2 bits (69), Expect = 9.5
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
P P +P P P PPPPP PPPP A
Sbjct: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 338 bits (868), Expect = 2e-92
Identities = 319/1197 (26%), Positives = 532/1197 (44%), Gaps = 138/1197 (11%)
Query: 104 TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 161
T +LDR+ ++ +V V I K EV I ++D NDN P F + TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 221
E G+ I A D D+G N + Y I DD D +G+++
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDPE------SGDLIA 1798
Query: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
+RL+ E +++Y ++++A+D Q+ + R + + V D +D P F
Sbjct: 1799 TRRLDRERRSKYSLLVRADDGLQSSDMR------INITVSDVNDHTPKF----------- 1841
Query: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
RP+ Y IPE P L I+ A D D + I Y + +D
Sbjct: 1842 SRPV-YSFDIPEDTIPGSLVAAIL-----ATDDDSGVNGE-----ITYIV---NEDDEDG 1887
Query: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401
F ++P T +L ++ + Q + L ++AE G ++ ILD N+ P F+
Sbjct: 1888 IFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTI--RVYFNILDVNDNPPIFS 1945
Query: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
+ SY ++E+ PVG+T+ N+T D +D S + + D
Sbjct: 1946 LNSYSTSLMENLPVGSTVL-VFNVT----------DADDGINSQLTYS-----IASGDSL 1989
Query: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE-----SEPVIVNIQVMDAND 516
FTV + G+ L +L+ +DRE Q Y + D Q + V+I ++D ND
Sbjct: 1990 GQFTVDKNGV---LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVND 2046
Query: 517 NTPTF--PEISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGDFIINKT 573
N PTF P+++Y + P D+V+ + A D D G N I Y +L F I
Sbjct: 2047 NPPTFLSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTI 2102
Query: 574 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 633
G + + ++ Y LTV A D P+ ++ V + + NN P F Q +Y
Sbjct: 2103 DGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN---PIFAQALY 2159
Query: 634 SLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDR 690
+EI+E G ++ + A D + + Y I NG+ + F + TG +T+ K LDR
Sbjct: 2160 KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDR 2219
Query: 691 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD--PY---LPRNLSVVEEEA 744
E T Y L + A+D G T T+TV+IV+ D+ND PVF+ PY +P NL +
Sbjct: 2220 EKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT- 2278
Query: 745 NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 802
+ QV A D D G N ++ Y L GN +N F ++++G + L+RE ++ + L++
Sbjct: 2279 ---ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMIT 2335
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 862
ATD T T+ + V D++DN P F + Y + E+ P GT +L + A D D
Sbjct: 2336 ATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASK 2395
Query: 863 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 922
N RI + F ++P TG++ LD E + + T +V D P +
Sbjct: 2396 NAVIRIIGGNSQ--FTINPSTGQIITSALLDRET----KDNYTLVVVCSDAGSPEPLSSS 2449
Query: 923 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 981
T V V V D+ND PP F Y + + G+ + V DAD P S + Y +
Sbjct: 2450 TSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLSG 2507
Query: 982 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1041
+ F ++ G ++ LN F + V D G + S TV + ++
Sbjct: 2508 RN----SEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNK 2561
Query: 1042 GEIPRFTQEEY-----RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINN 1096
+ P+ +E PVS L T + ++ + + Y I SGN +TF I+
Sbjct: 2562 ADFPKVRAKEQTFMFPENQPVSSLVTT-----ITGSSLRGEPMSYYIASGNLGNTFQIDQ 2616
Query: 1097 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1156
+TG + ++ PLD+E YV+ ++A + P S+ K+ I + D N++ P+F
Sbjct: 2617 LTGQVSISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLDVNDNAPIF 2669
Query: 1157 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI 1216
++ +I + E+ +L V A DKD+G + Y ++ + + F + TG I
Sbjct: 2670 KEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNM---ENSFSINHATGEI 2725
Query: 1217 KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD-----MQVIVSNVP 1268
++ + S++ + ++D S V+++++++ D Q+ ++VP
Sbjct: 2726 RSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Score = 326 bits (835), Expect = 1e-88
Identities = 299/1116 (26%), Positives = 504/1116 (45%), Gaps = 95/1116 (8%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
I V D ND+ P F + Y ++E P G+ + +G S ATD D G N + Y I
Sbjct: 463 IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV-SGIS----ATDGDSGLNANLRYSIVSG 517
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
+ + L+ TG+ L+ E ++ + I A D+ + + + L V
Sbjct: 518 NGLGWFHISEHSGLVTTGS---SGGLDRELASQIVLNISARDQGVH---PKVSYAQLVVT 571
Query: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
+LD +D P+F +P Y ++ E P ++ ++A D D
Sbjct: 572 LLDVNDEKPVF-----------SQPEGYDVSVVE-NAPTGTELLM----LRATDGDLG-- 613
Query: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
D + +S+ E R F + P + LS + ++R+ + L++ A P
Sbjct: 614 ---DNGTVRFSLQEA--ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPP 668
Query: 380 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
+ A +++ +LD N+ SP F Y +I E+ P G+ I+ +++ T P
Sbjct: 669 QSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYIT-TVSATDP----------- 716
Query: 440 DVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 498
D+ +G + + D + Q+G+ ++ +DREE+ Y I A DG
Sbjct: 717 DLGTNGTV----KYSISAGDRSRFQVNAQSGV---ISTRMALDREEKTAYQLQIVATDGG 769
Query: 499 -VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 557
+Q IV I V+D DN P F +++Y V+ ++ G V ++A D SN I+
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--IS 827
Query: 558 YEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 616
Y I G Q G F IN+ TG +T A ++ Y L V A+ + +I +
Sbjct: 828 YLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDL- 886
Query: 617 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF 673
N + P F Q + S+ + E + G + +A D + + Y+++ +P+ +F
Sbjct: 887 -----NDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLF 940
Query: 674 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 733
++E G ++L LD + I I+ + G P +S+ + + V DVNDN+PVFD
Sbjct: 941 AINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000
Query: 734 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNR 791
E N+ +V+A+D D+G NG++ Y++ GN + F I +G +Y +L+R
Sbjct: 1001 YEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDR 1060
Query: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
E++D Y L+VVA+D AV P +T+ + + + D++DN P+F ++ YT EE AG+ +
Sbjct: 1061 ELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVG 1120
Query: 852 QIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 911
++ A D D G N R V+ F LH +GE++ D E+ + + F
Sbjct: 1121 KVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVI 1180
Query: 912 DIYGTMPPGI---ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP- 967
+P + ATV V +KD+ND P F K Y+ ++ A T + V A D D
Sbjct: 1181 ATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEG 1240
Query: 968 -PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
GL + ++ Q F ++ SG+V L+ E T + LV+ A D G
Sbjct: 1241 NNGLIHYSIIKGNEERQ-------FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTI 1293
Query: 1027 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYS 1082
++S+ T+ I +L + + V E G +V ++A + N + YS
Sbjct: 1294 PLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYS 1353
Query: 1083 IVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1142
I N TF I+ TG I++ LD+ET++ Y L + A + P +S+T V
Sbjct: 1354 ITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITA-------KDQGRPPRSSTMSV 1406
Query: 1143 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1202
I ++D N++PP F + E+ + TSV+ V A D D ++Y II +
Sbjct: 1407 VIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPR 1465
Query: 1203 GKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
G F ++ G I T + F+ V A D
Sbjct: 1466 GNH-FTIDEVKGTIYTNAEIDREFANLFELTVKAND 1500
Score = 296 bits (757), Expect = 2e-79
Identities = 307/1147 (26%), Positives = 503/1147 (43%), Gaps = 128/1147 (11%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
EVR++VRD NDN+P F S T E + G + + ATD D G NG
Sbjct: 120 EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVIL-----DTATDSDIGSNGVDHRSY 174
Query: 197 QYNPDDPTSNDTFEIPLMLTG-----NIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 251
+ + +I L +G ++V + L+ E +Y ++++ D+ + +R
Sbjct: 175 RIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGE---PKRR 231
Query: 252 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 311
+ V V D +D P+F YQA +PE + ++ + +Q
Sbjct: 232 GYLQVNVTVQDINDNPPVF------------GSSHYQAGVPE-------DAVVGSSVLQV 272
Query: 312 IDQDRNIQPPSDRPGILYSIL-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
D + +D I Y + GTP F M P T +++ EP++ + +++ L +
Sbjct: 273 AAADADEGTNAD---IRYRLQDEGTP------FQMDPETGLITVREPLDFEARRQYSLTV 323
Query: 371 KAEQDNGHP-LPAFAGLHIEILDENNQSP-----YFTMPSYQGYILESAPVGATISDSLN 424
+A D G P L A I++LD N+ P YF S + E+A VG ++
Sbjct: 324 QA-MDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVA---- 378
Query: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITR--YLTLLQPVD 482
+ D D S + + + + F V + + + + +D
Sbjct: 379 -----LLTVTDAD------SPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALD 427
Query: 483 REEQQTYTFSITAFDGV---------QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTD 533
RE +Y +++ D S + I V D ND+ P F + Y V + +
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487
Query: 534 MRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI--APGVEMIVGRT 590
PG V ++A D D G N + Y I+ G G F I++ +GL+T + G++ +
Sbjct: 488 APPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQ 547
Query: 591 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650
L + A D + S + + +L N++ P Y + + E G LL L
Sbjct: 548 IVLNISARDQG--VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLML 605
Query: 651 QATDRE-GD--SITYAIENGD-PQRVFNLSETTGILTLGKALDRESTDRYILIITASD-G 705
+ATD + GD ++ ++++ + +R F L +G L+ +LDRE Y L++ A+D G
Sbjct: 606 RATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665
Query: 706 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 765
P +S A +N+ + D+NDN+PVF P E +++ V ATDPD G NG V
Sbjct: 666 SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVK 725
Query: 766 YSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 823
YS+ G+ + +G I T + L+RE + Y+L +VATDG + + I VLD
Sbjct: 726 YSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLD 785
Query: 824 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFT 883
DN PVF+ Y+ +V EN+ G + + A +DL +N+SY I + + K FA++ T
Sbjct: 786 TQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVT 845
Query: 884 GELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 943
G+L+ + D+E + ++ GT+ G V + VKD+ND P F + I
Sbjct: 846 GQLTTANVI------DREEQSFYQLKVVASGGTV-TGDTMVNITVKDLNDNSPHFLQAIE 898
Query: 944 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 1003
V + G I A+ DP V Y + P ++F + E +G +
Sbjct: 899 SVNVVENWQAGHSI--FQAKAVDPDEGVNGMVLYSLKQ----NPKNLFAINEKNGTISLL 952
Query: 1004 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELAT 1062
L+ + +++ ++A D G P +SSS + + V + P F Q Y +SE
Sbjct: 953 GPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE-VTLSESEP 1010
Query: 1063 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1118
+ + A + N I Y+I GN D FGI G +Y+ LD E + YVL
Sbjct: 1011 VNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLM 1069
Query: 1119 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
VV ++ V S T V + ++D N++ P+F Y E+ R + V +V
Sbjct: 1070 -------VVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKV 1122
Query: 1179 KATDKDTGNYSVMAYRL-IIPPIKEGKEGFVVETYTGLIKTAMLFHN---MRR---SYFK 1231
A DKD G + Y ++ P F + +G I F MRR + F
Sbjct: 1123 SAVDKDFGPNGEVRYSFEMVQP------DFELHAISGEITNTHQFDRESLMRRRGTAVFS 1176
Query: 1232 FQVIATD 1238
F VIATD
Sbjct: 1177 FTVIATD 1183
Score = 288 bits (736), Expect = 4e-77
Identities = 287/1080 (26%), Positives = 474/1080 (43%), Gaps = 107/1080 (9%)
Query: 207 DTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDL 266
+TF+I LTG + + + L++E +Y V I+A D ++ L + VLD +D
Sbjct: 2610 NTFQID-QLTGQVSISQPLDFEKIQKYVVWIEARDGGF---PPFSSYEKLDITVLDVNDN 2665
Query: 267 GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG 326
P+F + + + I E +P + I+T + A+D+D D
Sbjct: 2666 APIF------------KEDPFISEILENLSPRK----ILT--VSAMDKDSGPNGQLD--- 2704
Query: 327 ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL 386
Y I+ G E+ F ++ T E+ + P++R+ + L IK+ +
Sbjct: 2705 --YEIVNGNMENS---FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKV 2759
Query: 387 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGV 446
I ILDEN+ +P F+ + ++ E++P+G T++ R+ D+DI S
Sbjct: 2760 MINILDENDNAPRFSQ-IFSAHVPENSPLGYTVT---------RVTTSDEDIGINAISRY 2809
Query: 447 PTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI 506
D L +N T +++ P++RE+ Y ++A D +
Sbjct: 2810 SIMDASLPFTINPSTGDIVISR-----------PLNREDTDRYRIRVSAHDSGW-TVSTD 2857
Query: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 566
V I V D NDN P F SY + G V Q+ A D DEGSNG++ Y + +Q
Sbjct: 2858 VTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY--FIKSQS 2915
Query: 567 DFI-INKTTGLI--------TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
++ IN TTG I G + ++ V ++D P+ + T+ I
Sbjct: 2916 EYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV- 2974
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVF 673
+N + P+F + Y +++ ++VG L+ + A D + + Y I N + F
Sbjct: 2975 --DSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKF 3032
Query: 674 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 732
L TG +++ +L + + + +TA D G P +S ATV+I VT+ N + P F
Sbjct: 3033 KLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQS 3092
Query: 733 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-L 789
+ V V A D DA +NG + YS+ GN +F I S+ I T K L
Sbjct: 3093 HMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKAL 3152
Query: 790 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 849
+ E+ +E+ + A DG R ++ + V+D++DNSPVF + Y V EN P+GTT
Sbjct: 3153 DYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTT 3212
Query: 850 ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 907
++ + A D D G N ++Y ++S + F + P TG ++ LD+E + S
Sbjct: 3213 VIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET----KQSYHLT 3267
Query: 908 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 967
V+AF++ ATV + +K N+Y P F ++Y ++ A KGT + V+A D D
Sbjct: 3268 VKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDL 3327
Query: 968 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA--FDDGE 1025
V Y + F++ + +G++ L+ E L V+A F
Sbjct: 3328 G--TDGEVHYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIR 3382
Query: 1026 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-----QSIV 1080
TV + VL + P FT Y +SE GT V +SA +
Sbjct: 3383 GADIDEVTVNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFS 3441
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Y I SGNE F IN TG I V LD ET Y +L V+ + PS + +A
Sbjct: 3442 YFIGSGNENGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAVDSGTPSATGSA 3494
Query: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNYSVMAYRLIIPP 1199
+ + ++D N++ P+ G V E+ R T V+ +++TD D N Y L+
Sbjct: 3495 SLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL--S 3550
Query: 1200 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
F + T G++ T + + F V+ D +S V ++V++Q D
Sbjct: 3551 TGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Score = 282 bits (722), Expect = 2e-75
Identities = 254/852 (29%), Positives = 385/852 (45%), Gaps = 78/852 (9%)
Query: 465 TVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP-----VIVNIQVMDANDN 517
T+ +G +L L+ +DRE Y + D + EP + VN+ V D NDN
Sbjct: 190 TLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGYLQVNVTVQDINDN 246
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 577
P F Y V D G SV+Q+ A DADEG+N +I Y L F ++ TGLI
Sbjct: 247 PPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDEGTPFQMDPETGLI 305
Query: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP----PRFPQLMY 633
T+ ++ R Y+LTVQA D P+ I++L N+ P FP
Sbjct: 306 TVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEALIQLLDVNDNDPVVKFRYFPATSR 363
Query: 634 SLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSET----TGILTLG 685
+ E +VG V+ L TD + +I+ I G+ QR F + + ++ +
Sbjct: 364 YASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVA 423
Query: 686 KALDRESTDRYILIITASD--GRPDG------TSTATVNIVVTDVNDNAPVFDPYLPRNL 737
ALDRE Y L ++ SD G P G +S A++ I V D+ND+ PVF + R
Sbjct: 424 SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 738 SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTAVK---LNRE 792
E ++V + ATD D+G+N + YS+ + N L F I+ + + T L+RE
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 793 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTVLVEENLPAGTTIL 851
+ L + A D VHP+ S L + +LD++D PVF+ Y V V EN P GT +L
Sbjct: 544 LASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELL 603
Query: 852 QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
+ A D DLG N + R E + F L P +G LS + SLD E ++A + LV
Sbjct: 604 MLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE----EQAFYSLLV 659
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 968
A D+ +A + V + D+ND PVF Y + + G+ ITTV A D D
Sbjct: 660 LATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLG 719
Query: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
V+Y + S F+V SG + TR+ L+ E T ++L +VA D G
Sbjct: 720 --TNGTVKYSIS----AGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQS 773
Query: 1029 SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA--INQSIVYSIVSG 1086
+ A V I VL + P + V E G VG +SA+ +N +I Y I +G
Sbjct: 774 PNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTG 833
Query: 1087 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1146
+++ F IN +TG + +D E ++ Y L+V A V + V I +
Sbjct: 834 DQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV----------TGDTMVNITV 883
Query: 1147 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1206
+D N++ P F + V E+ + S+ + KA D D G ++ Y L P K
Sbjct: 884 KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNP----KNL 939
Query: 1207 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV---------SVVNQ 1257
F + G I ++ ++ +++A+D LS + V V +Q
Sbjct: 940 FAINEKNGTISLLGPL-DVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQ 998
Query: 1258 LDMQVIVSNVPP 1269
L +V +S P
Sbjct: 999 LSYEVTLSESEP 1010
Score = 278 bits (712), Expect = 3e-74
Identities = 315/1205 (26%), Positives = 524/1205 (43%), Gaps = 142/1205 (11%)
Query: 80 LSLKDNVDYWVLMDPVKQMLFLN------STGRVLDRDPPMNIHSIVVQVQCINKKVGTI 133
+ L N+ Y + K M +N +T V+DR+ VV GT+
Sbjct: 820 MDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA------SGGTV 873
Query: 134 IYHE-VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
V I V+D NDNSP F V E G +IF A D D+G NG +
Sbjct: 874 TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQA-----KAVDPDEGVNGMV 928
Query: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Y ++ NP + + + + L G + + Y + I A+D + ++
Sbjct: 929 LYSLKQNPKNLFAINEKNGTISLLGPLDVH-------AGSYQIEILASDMGV---PQLSS 978
Query: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
+ LTV V D +D P+F L+Y+ + E E +N +QA
Sbjct: 979 SVILTVYVHDVNDNSPVF------------DQLSYEVTLSE---SEPVNSRFF--KVQAS 1021
Query: 313 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 372
D+D I Y+I G D F + P +L + ++R+ ++ L++ A
Sbjct: 1022 DKDSGANGE-----IAYTIAEGNTGD---AFGIFP-DGQLYIKSELDRELQDRYVLMVVA 1072
Query: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
PL A + + + D N+ P F +Y Y E G+ + ++
Sbjct: 1073 SDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVG---------KVS 1123
Query: 433 ALDKDIEDVPPSG-------VPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 485
A+DKD P+G + D ELH + T+ + + R R
Sbjct: 1124 AVDKDF---GPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMR---------RRG 1171
Query: 486 QQTYTFSITAFD-GVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ 542
++F++ A D G+ + + V++ + D NDN P F + Y + V++
Sbjct: 1172 TAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLR 1231
Query: 543 LTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 601
++A D DEG+NG I Y I+ G + F I+ T+G +T+ ++ Y+L +QA D+
Sbjct: 1232 VSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSG 1291
Query: 602 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDS- 659
NS CT+ I++L N+ + P FP+ +++ E MR+G ++ ++ ATD + GD+
Sbjct: 1292 --TIPLNSTCTLNIDILDENDNT-PSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNA 1348
Query: 660 -ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 717
+ Y+I + F++S TG + L K LD E+ Y L ITA D GRP +ST +V I
Sbjct: 1349 DLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVI 1408
Query: 718 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL------GNF 771
V D NDN P F P V V V A DPDA INGQ+ Y++ GN
Sbjct: 1409 HVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH 1468
Query: 772 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAV---HPRHSTLTLAIKVLDIDDNS 828
+ + G+IYT +++RE + +EL V A D AV R++ + I V D++DN
Sbjct: 1469 FTIDEV--KGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNV 1526
Query: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 886
P+F S + + + G+ + I A D D GAN + Y I + + F + ++G+L
Sbjct: 1527 PMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFI-VDRYSGDL 1584
Query: 887 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGM 946
+ +L P Q +V A D+ +T+I++ ++ PVF++ Y +
Sbjct: 1585 RVASAL----VPSQ-LIYNLIVSATDLGPERRKSTTELTIILQGLDG--PVFTQPKYITI 1637
Query: 947 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP--ASIFEVEEDSGRVITRV 1004
+ GT + ++ E A P G A V Y + V+ +F + +G + T
Sbjct: 1638 LKEGEPIGTNVISI--EAASPRGSEAP-VEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAA 1694
Query: 1005 NLNEEPTTIFKLV-VVAFDDGEPV-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1062
L+ E LV V A + + A V+I + + P + V E
Sbjct: 1695 ILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIG 1754
Query: 1063 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1118
G+ + ++A N + Y+I+SG +D+F I+ +G + LD E R+ Y L
Sbjct: 1755 DGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLL 1813
Query: 1119 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
V+AD +S+ ++ I + D N+H P F + Y + ED + V +
Sbjct: 1814 VRADD----------GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAI 1863
Query: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1237
ATD D+G + Y + ++ ++G F + TG+ L + Y+ V A
Sbjct: 1864 LATDDDSGVNGEITYIV----NEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAE 1919
Query: 1238 DDYGK 1242
D G+
Sbjct: 1920 DGGGQ 1924
Score = 273 bits (698), Expect = 1e-72
Identities = 343/1312 (26%), Positives = 567/1312 (43%), Gaps = 148/1312 (11%)
Query: 44 PPATIVAIDEESRNGTILVDNMLIKGTAG--GPDPTIELSLKD-NVDYWVL-MDPVKQML 99
P V++ E + GT L ++++ T G G + T+ SL++ D +DPV L
Sbjct: 585 PEGYDVSVVENAPTGTEL---LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRL 641
Query: 100 FLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 159
ST LDR+ +V+ + ++ + + + D NDNSP F Y+A
Sbjct: 642 ---STISSLDREEQAFYSLLVLATDLGSPPQSSMA--RINVSLLDINDNSPVFYPVQYFA 696
Query: 160 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNI 219
+ E P G+ I T ATD D G NG ++Y I F++ +G I
Sbjct: 697 HIKENEPGGSYITT-----VSATDPDLGTNGTVKYSISAG-----DRSRFQVNAQ-SGVI 745
Query: 220 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
R L+ E+KT Y + I A D N + +T+ VLD D P+F
Sbjct: 746 STRMALDREEKTAYQLQIVATDGG---NLQSPNQAIVTITVLDTQDNPPVF--------- 793
Query: 280 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 339
+ Y + E L + + +D + NI Y I G D
Sbjct: 794 ---SQVAYSFVVFE---NVALGYHVGSVSASTMDLNSNIS---------YLITTG---DQ 835
Query: 340 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 399
F ++ T +L+ ++R+ + L + A +G + ++I + D N+ SP+
Sbjct: 836 KGMFAINQVTGQLTTANVIDREEQSFYQLKVVA---SGGTVTGDTMVNITVKDLNDNSPH 892
Query: 400 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLND 459
F ++E+ G +I + A+D P GV L+ +
Sbjct: 893 FLQAIESVNVVENWQAGHSI---------FQAKAVD------PDEGV--NGMVLYSLKQN 935
Query: 460 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPVIVNIQVMDANDN 517
++F + + T ++LL P+D +Y I A D GV Q S VI+ + V D NDN
Sbjct: 936 PKNLFAINEKNGT--ISLLGPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDN 992
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 577
+P F ++SY+V + ++ A D D G+NGEI Y I G GD G +
Sbjct: 993 SPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQL 1052
Query: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 637
I ++ + Y L V A+D A TV +E + N + P F Y+
Sbjct: 1053 YIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDV---NDNRPLFNSTNYTFYF 1109
Query: 638 SEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 694
E R G+ + + A D++ + Y+ E P F L +G +T DRES
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPD--FELHAISGEITNTHQFDRESLM 1167
Query: 695 R-------YILIITASDGRPDG-TSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEA 744
R +I G P ATV++ + D+NDNAP F D Y ++ E A
Sbjct: 1168 RRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFY---QATISESAA 1224
Query: 745 N-AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 800
N V +V A+D D G NG +HYS+ GN F I S +G + KL+ E Y LV
Sbjct: 1225 NLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLV 1284
Query: 801 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 860
+ A D P +ST TL I +LD +DN+P F ST V V EN+ G + + A D D
Sbjct: 1285 IQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDS 1344
Query: 861 G--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 918
G A++ Y I F++ P TG + L + LD+E + +IT + P
Sbjct: 1345 GDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQG------RP 1398
Query: 919 PGIATVTVI--VKDMNDYPPVFSK-RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 975
P +T++V+ V+D ND PP F I+K +V + GT + +V A D D ++
Sbjct: 1399 PRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPI-GTSVISVTAHDPDAD--INGQL 1455
Query: 976 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1035
Y + +Q + F ++E G + T ++ E +F+L V A D P+ + +K
Sbjct: 1456 SYTI--IQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALK 1513
Query: 1036 ---ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGN 1087
ILV + +P F + S A G+++ I AA N I Y I++G
Sbjct: 1514 NVTILVTDLNDNVPMFISQNALAADPS--AVIGSVLTTIMAADPDEGANGEIEYEIING- 1570
Query: 1088 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1147
+ DTF ++ +G + V L ++ Y L V A +L + +T ++ I +Q
Sbjct: 1571 DTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSA-------TDLGPERRKSTTELTIILQ 1622
Query: 1148 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG- 1206
+ PVF + YI + E + T+V+ ++A G+ + + Y ++ +E G
Sbjct: 1623 GLDG--PVFTQPKYITILKEGEPIGTNVISIEAA-SPRGSEAPVEYYIVSVRCEEKTVGR 1679
Query: 1207 -FVVETYTGLIKTAMLFHNMRRSYF----KFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1261
F + +TG+I+TA + + + + + + + + + ++ + +N +
Sbjct: 1680 LFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDIND-NPP 1738
Query: 1262 VIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLE 1313
V +++ VE+ I D ++I+ + GA +V D+F ++
Sbjct: 1739 VFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRID 1790
Score = 266 bits (681), Expect = 1e-70
Identities = 322/1154 (27%), Positives = 503/1154 (43%), Gaps = 132/1154 (11%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V I V D DN P F +Y V E +G + G A+ +D N I Y+I
Sbjct: 779 VTITVLDTQDNPPVFSQVAYSFVVFENVALGYHV-----GSVSASTMD--LNSNISYLIT 831
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
F I +TG + ++ E+++ Y + + A+ T T +
Sbjct: 832 TG----DQKGMFAIN-QVTGQLTTANVIDREEQSFYQLKVVASGGTV------TGDTMVN 880
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
+ V D +D P FL + E +N + +I Q +
Sbjct: 881 ITVKDLNDNSPHFLQAI-----------------------ESVNVVENWQAGHSIFQAKA 917
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ-KFDLVIKAEQDN 376
+ P G++ L P++ F ++ + +SLL P+ D H + + I A
Sbjct: 918 VDPDEGVNGMVLYSLKQNPKN---LFAINEKNGTISLLGPL--DVHAGSYQIEILASDMG 972
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
L + L + + D N+ SP F SY+ + ES PV + ++ A DK
Sbjct: 973 VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF---------FKVQASDK 1023
Query: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
D SG + + + F + G L + +DRE Q Y + A
Sbjct: 1024 D------SGA-NGEIAYTIAEGNTGDAFGIFPDG---QLYIKSELDRELQDRYVLMVVAS 1073
Query: 497 DGVQESEPVIVNIQVM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
D E VN+ V+ D NDN P F +Y Y + R G V +++AVD D G NG
Sbjct: 1074 DRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNG 1133
Query: 555 EITYEILVGAQGDFIINKTTGLITIAPGV--EMIVGR----TYALTVQAADNAPPAERRN 608
E+ Y + Q DF ++ +G IT E ++ R ++ TV A D P ++
Sbjct: 1134 EVRYSFEM-VQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKD 1192
Query: 609 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIE 665
TV++ + N + P+F + Y ISE+ +L + A+D EG++ I Y+I
Sbjct: 1193 Q-ATVHV-YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSII 1250
Query: 666 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 724
G+ +R F + T+G +TL LD E+T Y L+I A D G ST T+NI + D ND
Sbjct: 1251 KGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDEND 1310
Query: 725 NAPVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSLGNFNN--LFRIT 778
N P F P++ V+ N +G+ V ATD D+G N ++YS+ NN F I+
Sbjct: 1311 NTPSF----PKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSIS 1366
Query: 779 SN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 837
N GSI+ A KL+ E + Y+L + A D PR ST+++ I V D +DN P F
Sbjct: 1367 PNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIF 1426
Query: 838 VLVEENLPAGTTILQIEA--KDVDLGANVSYRI--RSPEVKHFFALHPFTGELSLLRSLD 893
+ EN+P GT+++ + A D D+ +SY I + P H F + G + +D
Sbjct: 1427 KSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH-FTIDEVKGTIYTNAEID 1485
Query: 894 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA--PDA 951
E E ++ +A I T + VT++V D+ND P+F I + +A P A
Sbjct: 1486 REFANLFELTVKANDQAVPI-ETRRYALKNVTILVTDLNDNVPMF---ISQNALAADPSA 1541
Query: 952 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 1011
V G+ +TT+ A ADP + Y + + F V+ SG + RV P+
Sbjct: 1542 VIGSVLTTIMA--ADPDEGANGEIEYEIINGD----TDTFIVDRYSGDL--RVASALVPS 1593
Query: 1012 TIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVIS 1071
+ ++V+ D P S T ++L + P FTQ +Y + E GT V I
Sbjct: 1594 QLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKY-ITILKEGEPIGTNVISIE 1652
Query: 1072 AAAINQS---IVYSIVSGN-EEDTFG----INNITGVIYVNGPLDYETRTSYVLRVQADS 1123
AA+ S + Y IVS EE T G I TG+I LD E L V +
Sbjct: 1653 AASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYL-VDVYA 1711
Query: 1124 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1183
+E A R + A+V I +QD N++PPVF V E+ + ++++ A D
Sbjct: 1712 IEKSTAFPR----TQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDA 1767
Query: 1184 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
D G +++ Y + I + F ++ +G LI T L R Y ++ DD +
Sbjct: 1768 DEGANALVTYTI----ISGADDSFRIDPESGDLIATRRLDRERRSKY--SLLVRADDGLQ 1821
Query: 1243 GLSGKADVLVSVVN 1256
+ ++ VS VN
Sbjct: 1822 SSDMRINITVSDVN 1835
Score = 265 bits (676), Expect = 4e-70
Identities = 283/1049 (26%), Positives = 474/1049 (45%), Gaps = 119/1049 (11%)
Query: 135 YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 193
Y ++ I V D NDN+P FK + + + + E L+P I T A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704
Query: 194 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 253
Y I + ++F I TG I + L+ E + Y + I+++D+ + ++T+
Sbjct: 2705 YEIV----NGNMENSFSIN-HATGEIRSVRPLDREKVSHYVLTIKSSDKG---SPSQSTS 2756
Query: 254 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 313
+ +++LD +D P F + A +PE +P VT D
Sbjct: 2757 VKVMINILDENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----D 2798
Query: 314 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 373
+D I S YSI+ D F ++P T ++ + P+NR+ ++ + + A
Sbjct: 2799 EDIGINAISR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848
Query: 374 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
D+G + + I + D N+ +P F+ SY E +G+ ++ ++ A
Sbjct: 2849 -DSGWTVST--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFA 2896
Query: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQ 487
D D + ++ F+ + F + T + + Q V
Sbjct: 2897 TDPD---------EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNIN 2947
Query: 488 TYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 545
++F +T+ D + S V I ++D+NDN P F + Y V +++ G +I++TA
Sbjct: 2948 RHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTA 3007
Query: 546 VD-ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 603
+D D G N E+ Y I G F ++ TG I++A + + + + +TV A D P
Sbjct: 3008 IDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 3067
Query: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---I 660
+S TV+I V N +P F Q S I E+ +G+++ + A DR+ I
Sbjct: 3068 P--LSSQATVHITVTEENYHTP-EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLI 3124
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNI 717
Y+I +G+ + +F ++ +TGILTL KALD E ++ + I+A DG G + TVN+
Sbjct: 3125 KYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNV 3184
Query: 718 VVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNL 774
+ DVNDN+PVF D Y P L + V + ATD D+G N + Y++ + ++L
Sbjct: 3185 I--DVNDNSPVFLSDDYFPTVLE--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDL 3240
Query: 775 FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
F I N G I T L+ E + Y L V A + R S T+ I++ ++ P F +
Sbjct: 3241 FVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVS 3300
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS 891
Y + E P GT + ++ A D DLG + V Y I K F ++ TG++ +
Sbjct: 3301 KLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI 3360
Query: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 951
LD E ++ S+ L + F TV V V D ND PP+F+ IY ++
Sbjct: 3361 LDREK--EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGV 3417
Query: 952 VKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
GT +T V A D+D +P+ SR Y + F + +G++ L+ E
Sbjct: 3418 PIGTHVTFVSAFDSD--SIPSWSRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRET 3472
Query: 1011 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGV 1069
I+ L V+A D G P + SA++ + + + P T E V E GT+V
Sbjct: 3473 LPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMT 3529
Query: 1070 ISAA----AINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1124
+ + NQ Y ++S ++ + GV+ +D E + L
Sbjct: 3530 LQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL------- 3582
Query: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHP 1153
VV + VP S+T V+I + D+N++P
Sbjct: 3583 SVVTKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 258 bits (658), Expect = 5e-68
Identities = 304/1164 (26%), Positives = 500/1164 (42%), Gaps = 140/1164 (12%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 196
V + ++D NDN+P F + Y AT++E T + A+D+D+G NG I Y +I
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV-----SASDVDEGNNGLIHYSII 1250
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ-NLNERRTTTTT 255
+ N + + D+ +G + L +L+YE Y ++IQA D LN +T T
Sbjct: 1251 KGNEERQFAIDS------TSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLN----STCT 1300
Query: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
L +D+LD +D P F L + + +R E ++ + T D D
Sbjct: 1301 LNIDILDENDNTPSFPKSTL-----------FVDVLENMRIGELVSSVTAT------DSD 1343
Query: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
D + YSI T + F + P T + L + ++ + + L I A+
Sbjct: 1344 SG-----DNADLYYSI---TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ 1395
Query: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
P + + I + D N+ P F I+E+ P+G ++ S+ P D
Sbjct: 1396 GRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVI-SVTAHDP------D 1448
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
DI + + P + FT+ + T Y +DRE + ++ A
Sbjct: 1449 ADINGQLSYTIIQQMPR--------GNHFTIDEVKGTIYTNA--EIDREFANLFELTVKA 1498
Query: 496 FDGVQESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ-LTAVDAD 549
D E V I V D NDN P F IS + SV+ + A D D
Sbjct: 1499 NDQAVPIETRRYALKNVTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPD 1556
Query: 550 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
EG+NGEI YEI+ G FI+++ +G + +A + + Y L V A D P + +
Sbjct: 1557 EGANGEIEYEIINGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTT 1615
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-------ITY 662
T+ ++ L P F Q Y + E +G +++++A G ++
Sbjct: 1616 ELTIILQGL-----DGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSV 1670
Query: 663 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI----ITASDGRPDGTSTATVNIV 718
E R+F + TGI+ LDRE L+ I S P T A V I
Sbjct: 1671 RCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFP-RTQRAEVEIT 1729
Query: 719 VTDVNDNAPVFDPYLPRNLSVVEEEAN-AFVGQVKATDPDAGINGQVHYS-LGNFNNLFR 776
+ D+NDN PVF P +L+V E + + + Q+ A D D G N V Y+ + ++ FR
Sbjct: 1730 LQDINDNPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFR 1788
Query: 777 I-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 835
I +G + +L+RE R Y L+V A DG + S + + I V D++D++P F+
Sbjct: 1789 IDPESGDLIATRRLDRERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPV 1845
Query: 836 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 893
Y+ + E+ G+ + I A D D G N ++Y + + F L+P TG +L R LD
Sbjct: 1846 YSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLD 1905
Query: 894 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPDA 951
YE + V A D G T+ V + D+ND PP+FS Y + +
Sbjct: 1906 YEV----QQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENL 1957
Query: 952 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEP 1010
G+ + DAD G+ S++ Y + S+ + D V+ + L+ E
Sbjct: 1958 PVGSTVLVFNVTDAD-DGI-NSQLTYSIASGD-----SLGQFTVDKNGVLKVLKALDRES 2010
Query: 1011 TTIFKLVVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEE--YRP--PPVSELAT 1062
+ + LVV D + S S+A V I++L + P F + Y P P+ +
Sbjct: 2011 QSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVF 2070
Query: 1063 KGTMVGVISAAAINQSIVYSIVS--GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
K S N I Y++++ GN+ F I I G + + G LD E ++Y
Sbjct: 2071 KAQATDPDSGP--NSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNY----- 2120
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
+L VV + PS S++ +V + + D N++ P+F + Y ++E+ T +++V A
Sbjct: 2121 --TLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFA 2178
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
D D G + Y ++ + F +++ TG I A + + V ATD
Sbjct: 2179 ADGDEGTNGQVRYGIV---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD-- 2233
Query: 1241 GKGLSGKADVLVSVVNQLDMQVIV 1264
+G + + D + LD+ V
Sbjct: 2234 -RGSTPRTDTSTVSIVLLDINDFV 2256
Score = 249 bits (636), Expect = 2e-65
Identities = 288/1098 (26%), Positives = 466/1098 (42%), Gaps = 116/1098 (10%)
Query: 135 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 194
Y +V + V+D NDN P F Y A V E VG+++ A D D+G N I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287
Query: 195 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
+Q + P D TG I +R+ L++E + +Y + +QA DR R
Sbjct: 288 RLQ-DEGTPFQMDP------ETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL 340
Query: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
+DV D D P+ P ++ + A+
Sbjct: 341 IQLLDVNDND-------------------PVVKFRYFPATSRYASVDENAQVGTVVALLT 381
Query: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMH----PRTAELSLLEPVNRDFHQKFDLVI 370
+ P+ I IL G + R F + P + + + ++R+ ++L +
Sbjct: 382 VTDADSPAANGNISVQILGGNEQ---RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTV 438
Query: 371 KAEQDNGHPLPA-------FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 423
+ G P A A L I + D N+ P F+ Y+ + E AP G+ +S +
Sbjct: 439 SVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVS-GI 497
Query: 424 NLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 483
+ T + + V +G+ +++++ + T +G +DR
Sbjct: 498 SATDGDSGLNANLRYSIVSGNGLG------WFHISEHSGLVTTGSSG---------GLDR 542
Query: 484 EEQQTYTFSITAFDGVQESEPVI----VNIQVMDANDNTPTF--PEISYDVYVYTDMRPG 537
E +I+A D Q P + + + ++D ND P F PE YDV V + G
Sbjct: 543 ELASQIVLNISARD--QGVHPKVSYAQLVVTLLDVNDEKPVFSQPE-GYDVSVVENAPTG 599
Query: 538 DSVIQLTAVDADEGSNGEITYEILVGAQGD---FIINKTTGLITIAPGVEMIVGRTYALT 594
++ L A D D G NG + + L A+ D F ++ +G ++ ++ Y+L
Sbjct: 600 TELLMLRATDGDLGDNGTVRFS-LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 595 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 654
V A D P + +S+ + + +L N+ SP +P + Y I E G+ + + ATD
Sbjct: 659 VLATDLGSPPQ--SSMARINVSLLDINDNSPVFYP-VQYFAHIKENEPGGSYITTVSATD 715
Query: 655 RE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 710
+ ++ Y+I GD R F ++ +G+++ ALDRE Y L I A+D G
Sbjct: 716 PDLGTNGTVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSP 774
Query: 711 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 769
+ A V I V D DN PVF + + V E A + VG V A+ D N + G
Sbjct: 775 NQAIVTITVLDTQDNPPVFS-QVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTG 833
Query: 770 NFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828
+ +F I G + TA ++RE + +Y+L VVA+ G V + I V D++DNS
Sbjct: 834 DQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNS 890
Query: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 886
P F + +V V EN AG +I Q +A D D G N V Y ++ K+ FA++ G +
Sbjct: 891 PHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTI 949
Query: 887 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGM 946
SLL LD A S + A D+ +TV V D+ND PVF + Y+
Sbjct: 950 SLLGPLDVHA-----GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVT 1004
Query: 947 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 1006
++ + V A D D + Y + + IF G++ + L
Sbjct: 1005 LSESEPVNSRFFKVQASDKDSGA--NGEIAYTIAEGNTGDAFGIF----PDGQLYIKSEL 1058
Query: 1007 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGT 1065
+ E + L+VVA D +S++ V +++ + P F Y E G+
Sbjct: 1059 DRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGS 1117
Query: 1066 MVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--V 1119
VG +SA N + YS + F ++ I+G I D R S + R
Sbjct: 1118 FVGKVSAVDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFD---RESLMRRRGT 1172
Query: 1120 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
S V+ + +P + A V++ ++D N++ P F K FY +SE A T VLRV
Sbjct: 1173 AVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV 1232
Query: 1179 KATDKDTGNYSVMAYRLI 1196
A+D D GN ++ Y +I
Sbjct: 1233 SASDVDEGNNGLIHYSII 1250
Score = 230 bits (587), Expect = 8e-60
Identities = 240/881 (27%), Positives = 382/881 (43%), Gaps = 106/881 (12%)
Query: 86 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDR 145
+ + +MD STG ++ P + +++ G + +V I V D
Sbjct: 2806 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865
Query: 146 NDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
NDN+P F SYY ELT +G+ + F ATD D+G NGQ+ Y I+ +
Sbjct: 2866 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF-----ATDPDEGSNGQVFYFIKSQSEYFRI 2920
Query: 206 NDTFEIPLMLTGNIVLRKRLNYEDKT--------RYFVIIQANDRAQNLNERRTTTTTLT 257
N T TG I ++ L Y++ T R+ I+ ++DR + + TT+T
Sbjct: 2921 NAT-------TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK---PSLISETTVT 2970
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ--AIDQD 315
++++D +D P FL + TP N + T I+ AID D
Sbjct: 2971 INIVDSNDNAPQFLK-------------------SKYFTPVTKNVKVGTKLIRVTAID-D 3010
Query: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
++ S+ + Y I + +++ F + T +S+ + D +Q F + + A+
Sbjct: 3011 KDFGLNSE---VEYFI---SNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDK 3064
Query: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
PL + A +HI + +EN +P F+ I ES +G+ + +++ R A++
Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR---TVSARDRDAAMN 3121
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
I+ SG + +F + + T LTL + +D E Q + +I+A
Sbjct: 3122 GLIKYSISSG-------------NEEGIFAINSS--TGILTLAKALDYELCQKHEMTISA 3166
Query: 496 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
DG V + V + V+D NDN+P F Y V + G +VI L A DAD G+N
Sbjct: 3167 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTN 3226
Query: 554 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 613
I Y + F+I+ TG+IT ++ ++Y LTV+A + P E R S TV
Sbjct: 3227 AVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATV 3284
Query: 614 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQ 670
I+ L N+ PRF +Y EISEA G ++ + A+DR+ + Y I +
Sbjct: 3285 NIQ-LKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRK 3343
Query: 671 RVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAP 727
+ F +++ TG + + LDRE +R L + A + R TVN+ V D ND
Sbjct: 3344 KGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND--- 3400
Query: 728 VFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL----GNFNNLFRIT- 778
P N+ V+ +G V A D D+ I +S GN N F I
Sbjct: 3401 --PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSINP 3457
Query: 779 SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 838
G I +L+RE Y L V+A D + +L + + DI+DN P+ T S V
Sbjct: 3458 QTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEV 3517
Query: 839 LVEENLPAGTTILQIEAKDVDLGAN----VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
+ EN GT ++ +++ D DL N Y + + +F+L G LS R +D
Sbjct: 3518 M--ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDR 3574
Query: 895 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 935
E D S+ D TV + V D ND P
Sbjct: 3575 EQIADFYLSVV----TKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 218 bits (555), Expect = 4e-56
Identities = 249/864 (28%), Positives = 380/864 (43%), Gaps = 79/864 (9%)
Query: 438 IEDVPPS---GVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
+E+ PP G P L++ ++F + + Y T +DRE + ++
Sbjct: 52 LEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTT--STIDRESLPSDVINLV 109
Query: 495 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
+ P V + V D NDN P FP+ S V D G VI TA D+D GSNG
Sbjct: 110 VLSSAP-TYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNG 168
Query: 555 --EITYEILVGAQ-GDFIINKTTG--------LITIAPGVEMIVGRTYALTVQAADNAPP 603
+Y I+ G + G F ++ T + G++ V Y L V+ D P
Sbjct: 169 VDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEP 228
Query: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITY 662
R V ++ + N +PP F Y + E VG+ +L + A D EG +
Sbjct: 229 KRRGYLQVNVTVQDI---NDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADI 285
Query: 663 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTD 721
D F + TG++T+ + LD E+ +Y L + A D G P T A I + D
Sbjct: 286 RYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLD 345
Query: 722 VNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKA----TDPDA-GINGQVHYSL--GNFNN 773
VNDN PV Y P + NA VG V A TD D+ NG + + GN
Sbjct: 346 VNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQR 405
Query: 774 LFRITSN-----GSIYTAVKLNREVRDYYELVVVATD-------GAVHPRHSTLTLAIKV 821
F + S+ I A L+RE Y L V +D AV R S +L I V
Sbjct: 406 HFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFV 465
Query: 822 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFAL 879
DI+D+ PVF+ Y V + E P G+ + I A D D L AN+ Y I S +F +
Sbjct: 466 NDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 880 HPFTGELSLLRS--LDYEAFPDQEASITFLVEAFDIYGTMPP-GIATVTVIVKDMNDYPP 936
+G ++ S LD E + I + A D G P A + V + D+ND P
Sbjct: 526 SEHSGLVTTGSSGGLDREL----ASQIVLNISARD-QGVHPKVSYAQLVVTLLDVNDEKP 580
Query: 937 VFSK-RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 995
VFS+ Y V +A GT + + A D D VR+ + + + + F ++
Sbjct: 581 VFSQPEGYDVSVVENAPTGTELLMLRATDGDLG--DNGTVRFSLQEAETDRRS--FRLDP 636
Query: 996 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRP 1054
SGR+ T +L+ E + L+V+A D G P SS A + + +L + P F +Y
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYF- 695
Query: 1055 PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1110
+ E G+ + +SA N ++ YSI +G + F +N +GVI LD E
Sbjct: 696 AHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDRE 754
Query: 1111 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1170
+T+Y L++ A NL+ P N A V I + D ++PPVF + Y V E+
Sbjct: 755 EKTAYQLQIVATD----GGNLQSP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVA 807
Query: 1171 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYF 1230
+ V V A+ D S ++Y LI ++G F + TG + TA + +S++
Sbjct: 808 LGYHVGSVSASTMDLN--SNISY-LITTGDQKGM--FAINQVTGQLTTANVIDREEQSFY 862
Query: 1231 KFQVIATDDYGKGLSGKADVLVSV 1254
+ +V+A+ G ++G V ++V
Sbjct: 863 QLKVVAS---GGTVTGDTMVNITV 883
Score = 186 bits (471), Expect = 2e-46
Identities = 205/752 (27%), Positives = 325/752 (43%), Gaps = 78/752 (10%)
Query: 568 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP--PAERRNSICTVYIEVLPPNNQSP 625
F IN +TG + ++ + + + +AP P E R V + L N +
Sbjct: 81 FAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR-----VLVRDL---NDNA 132
Query: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTG 680
P FP + E G ++ ATD + D +Y I G+ F L T
Sbjct: 133 PVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN 192
Query: 681 ILTLGK--------ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 731
G LDRE T +Y L++ D G P VN+ V D+NDN PVF
Sbjct: 193 PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS 252
Query: 732 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVK 788
+ V E+A + V QV A D D G N + Y L + F++ G I
Sbjct: 253 --SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310
Query: 789 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-----FTNSTYTVLVEEN 843
L+ E R Y L V A D V I++LD++DN PV F ++ V+EN
Sbjct: 311 LDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDEN 370
Query: 844 LPAGTTILQIEAKDVDLGA---NVSYRIRSP-EVKHFFALHPFTGELSLLR---SLDYEA 896
GT + + D D A N+S +I E +HF LSL++ +LD E
Sbjct: 371 AQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRER 430
Query: 897 FPDQEASITFLVEAFDIYGTMPPG--------IATVTVIVKDMNDYPPVFSKRIYKGMVA 948
P S V D YG PPG +A++ + V D+ND+PPVFS+++Y+ ++
Sbjct: 431 IP----SYNLTVSVSDNYGA-PPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLS 485
Query: 949 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--L 1006
+A G+ ++ + A D D GL A+ +RY + F + E SG V T + L
Sbjct: 486 EEAPPGSYVSGISATDGDS-GLNAN-LRYSIVSGN---GLGWFHISEHSGLVTTGSSGGL 540
Query: 1007 NEEPTTIFKLVVVAFDDG-EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1065
+ E + L + A D G P +S + V L+ E P F+Q E V E A GT
Sbjct: 541 DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600
Query: 1066 MVGVISAA----AINQSIVYSIVSGN-EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
+ ++ A N ++ +S+ + +F ++ ++G + LD E + Y
Sbjct: 601 ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFY----- 655
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
SL V+ +L P +S+ A++ + + D N++ PVF Y + E+ + + V A
Sbjct: 656 --SLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSA 713
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
TD D G + Y + + F V +G+I T M ++ ++ Q++ATD
Sbjct: 714 TDPDLGTNGTVKYSISAGD----RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769
Query: 1241 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1272
+A V ++V++ D + S V + V
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Score = 172 bits (436), Expect = 3e-42
Identities = 186/645 (28%), Positives = 296/645 (45%), Gaps = 61/645 (9%)
Query: 650 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 709
L T + TY + + +F ++ +TG L +DRES ++ + P
Sbjct: 60 LVGTIQTRPGFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP-- 115
Query: 710 TSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQVH 765
T V ++V D+NDNAPVF DP ++ V +E ++ QV ATD D G NG H
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVDH 171
Query: 766 YSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPRH 812
S GN FR IT N S + + L+REV Y+L+V D R
Sbjct: 172 RSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRR 231
Query: 813 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 872
L + + V DI+DN PVF +S Y V E+ G+++LQ+ A D D G N R R +
Sbjct: 232 GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD 291
Query: 873 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 932
F + P TG +++ LD+EA ++ S+T V+A D G A + + D+N
Sbjct: 292 EGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDVN 347
Query: 933 DYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFPY 986
D PV R + V +A GT + + DAD P + V+ + Q +
Sbjct: 348 DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF 407
Query: 987 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHPG 1042
+V S + L+ E + L V D+ G P + + ++V LV+
Sbjct: 408 EVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVN 466
Query: 1043 EI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGI 1094
+I P F+Q+ YR +SE A G+ V ISA + +N ++ YSIVSGN F I
Sbjct: 467 DINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 1095 NNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1152
+ +G++ +G LD E + VL + A + V K + A++ + + D N+
Sbjct: 526 SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVNDE 578
Query: 1153 PPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
PVF Q + Y V E+A T +L ++ATD D G+ + R + + + F ++
Sbjct: 579 KPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLDP 636
Query: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1256
+G + T ++++ V+ATD S A + VS+++
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Score = 170 bits (430), Expect = 1e-41
Identities = 198/763 (25%), Positives = 324/763 (42%), Gaps = 81/763 (10%)
Query: 114 MNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 173
+N HS +V K I V I + D NDN+P F Y+ V + VGT +
Sbjct: 2946 INRHSFIV-TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004
Query: 174 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDK 230
+ D D D G N ++EY I SND L TG I + L +
Sbjct: 3005 VTAID----DKDFGLNSEVEYFI--------SNDNHLGKFKLDNDTGWISVASSLISDLN 3052
Query: 231 TRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 290
+F+ + A D+ N ++ T+ + V + + P F + A
Sbjct: 3053 QNFFITVTAKDKG---NPPLSSQATVHITVTEENYHTPEFSQSHM------------SAT 3097
Query: 291 IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 350
IPE + I+ T + A D+D + I YSI G E F ++ T
Sbjct: 3098 IPE---SHSIGSIVRT--VSARDRDAAMNGL-----IKYSISSGNEEG---IFAINSSTG 3144
Query: 351 ELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 410
L+L + ++ + QK ++ I A + + + ++D N+ SP F Y +L
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204
Query: 411 ESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTG 470
E+AP G T+ + + A D D + + LF+ D TG
Sbjct: 3205 ENAPSGTTV---------IHLNATDADSGTNAVIAYTVQSSDSDLFVID-------PNTG 3248
Query: 471 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP--VIVNIQVMDANDNTPTFPEISYDV 528
+ +T +D E +Q+Y ++ AF+ E VNIQ+ N+ P F Y
Sbjct: 3249 V---ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYF 3305
Query: 529 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIV 587
+ G V ++ A D D G++GE+ Y I + + F INK TG I ++ ++
Sbjct: 3306 EISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK 3365
Query: 588 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 647
+L V A + TV + VL N+ PP F +YS++ISE + +G +
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND--PPIFTLNIYSVQISEGVPIGTHV 3423
Query: 648 LNLQATDREG----DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 703
+ A D + +Y I +G+ F+++ TG +T+ LDRE+ Y L + A
Sbjct: 3424 TFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAV 3483
Query: 704 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN- 761
D G P T +A++ + + D+NDN P+ + + + V +++TDPD N
Sbjct: 3484 DSGTPSATGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQ 3541
Query: 762 GQVHY---SLGNFNNLFRITSNGSIYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTL 817
G Y S G + F +++ G + T +++RE + D+Y L VV D V ST T+
Sbjct: 3542 GPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFY-LSVVTKDSGVPQMSSTGTV 3600
Query: 818 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 860
I V+D +DN V NL G + ++ +D D+
Sbjct: 3601 HITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 150 bits (379), Expect = 1e-35
Identities = 187/718 (26%), Positives = 299/718 (41%), Gaps = 101/718 (14%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V I V + N ++P F AT+ E +G+ + T A D D NG I+Y I
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-----SARDRDAAMNGLIKYSIS 3129
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
++ F I TG + L K L+YE ++ + I A D RT ++T
Sbjct: 3130 SGNEE----GIFAINSS-TGILTLAKALDYELCQKHEMTISAIDGGW---VARTGYCSVT 3181
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
V+V+D +D P+FL P + P + ++ +Q+ D D
Sbjct: 3182 VNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-- 3239
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
F + P T ++ ++ + Q + L +KA
Sbjct: 3240 ------------------------LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPD 3275
Query: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
+FA ++I++ N P F Y I E+AP G + + + A D+D
Sbjct: 3276 EERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE---------VFASDRD 3326
Query: 438 IEDVPPSGVPTKDPELH--LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
+ D E+H +F N F + + Y++ + +DRE+++ + + A
Sbjct: 3327 LGT---------DGEVHYLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLA 3375
Query: 496 --FDGVQ--ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE- 550
F ++ + + V VN+ V+DAND P F Y V + + G V ++A D+D
Sbjct: 3376 KNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSI 3434
Query: 551 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
S +Y I G + G F IN TG IT+ ++ Y L+V A D+ P+ ++
Sbjct: 3435 PSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSA 3494
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSL-EISEAMRVGAVLLNLQATD-----REGDSITYA 663
V +E + N P L S E+ E R G +++ LQ+TD +G Y
Sbjct: 3495 SLLVTLEDINDNG------PMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYL 3548
Query: 664 IENGDPQRVFNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDV 722
+ G F+LS T G+L+ + +DRE D Y+ ++T G P +ST TV+I V D
Sbjct: 3549 LSTGPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQ 3607
Query: 723 NDNAPVFDPYLPRNLSV-VEEEANAF----VGQVKATDPDAGINGQVHYSL-GNFNNLFR 776
NDN P R + + V N F +G VK DPD + H SL +LF
Sbjct: 3608 NDN-----PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD--VLDSFHCSLTSGVTSLFS 3660
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 834
I G R ++L V++ DG HST+T I+V ++ NS
Sbjct: 3661 IP--GGTCDLNSQPRSTDGTFDLTVLSNDGV----HSTVTSNIRVFFAGFSNATVDNS 3712
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 323 bits (828), Expect = 9e-88
Identities = 332/1217 (27%), Positives = 545/1217 (44%), Gaps = 128/1217 (10%)
Query: 104 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 163
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 164 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 223
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 484 SVPVGTSVLTV-----SASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
Query: 224 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
L++E Y I++A+D T+ + N D
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIG------------------NVNDN 574
Query: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
PL + A + + + +T + AID D + + Y I+ G F
Sbjct: 575 SPLFEKVACQGVISYDFPVGGHITA-VSAIDID-------ELELVKYKIISGNELG---F 623
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
F+++P + L L + + + + ++ +G L ++I +L S F+
Sbjct: 624 FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
Query: 403 PSYQ--GYILESAPVGATISDSLNLTSP-LRIVALDKD---IEDVPPSGVPTKDPE---- 452
+ + E + A + LNL L ++++ + PS V K+
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 453 --LHLFLNDYTS------VFTVTQTGI---------TRYLTLLQPVDREEQQTYTFSITA 495
L + D S +FT++ T L +L P+DRE Y +IT
Sbjct: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
Query: 496 FD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
+D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D GSN
Sbjct: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
Query: 554 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 613
GE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S+ T+
Sbjct: 864 GEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTL 922
Query: 614 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQ 670
+ + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N D
Sbjct: 923 KVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYN 980
Query: 671 RVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPV 728
F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+N +
Sbjct: 981 GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN--L 1038
Query: 729 FDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT---SNG 781
PY P V + N+ +G QV A D D+G +G++ YS+ + + L R + +G
Sbjct: 1039 HTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESG 1098
Query: 782 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 841
I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y +V
Sbjct: 1099 VITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVM 1158
Query: 842 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFP 898
EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD E
Sbjct: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE--- 1215
Query: 899 DQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD---AVK 953
Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+ +
Sbjct: 1216 -QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERDRKKR 1271
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
G PI +A D D P + + Y + D F ++ +G V +R I
Sbjct: 1272 GEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAGSYDI 1326
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTMVGVI 1070
L + A D+G P SS+A + I + P IP E + V E +VGV+
Sbjct: 1327 --LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV 1384
Query: 1071 SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLA 1129
S N + + IV GN + F G I + PLD E R+ Y + V+ D V +
Sbjct: 1385 SVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV- 1443
Query: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
+V+I++ D N++ P F + Y +SED T +L+++ATD+D +
Sbjct: 1444 ----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
Query: 1190 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249
I I K F ++ TG++ TA + + ++ D A
Sbjct: 1494 SYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
Query: 1250 VLVSVVNQLDMQVIVSN 1266
V+V+V + D +N
Sbjct: 1552 VIVNVEDANDHSPYFTN 1568
Score = 311 bits (798), Expect = 3e-84
Identities = 319/1129 (28%), Positives = 505/1129 (44%), Gaps = 111/1129 (9%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 254
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
Query: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
Query: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
D I YS+ + P + N+ + +KA
Sbjct: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
Query: 375 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
D G P+ + ++I +L P FT Y I E +G+T+ L S
Sbjct: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPS------ 2735
Query: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
++V S V + PE N+ +F + Q T + L + +DRE + F +
Sbjct: 2736 -----QNVWFSTVNGERPE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKV 2783
Query: 494 TA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 550
A D V V V+I+V+D NDN P F SYD + M G + Q+ A+D D
Sbjct: 2784 AATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDW 2843
Query: 551 GSNGEITYEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 605
G+NG++TY + +Q + F I+ TG I+ ++ T+ +V A+D A
Sbjct: 2844 GANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AF 2902
Query: 606 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----T 661
+S V + V N+ +P F Q +Y + E+ G V+ L DR+ + +
Sbjct: 2903 SLSSTALVSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVS 2961
Query: 662 YAIENGDPQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
Y I G+P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V
Sbjct: 2962 YHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSV 3019
Query: 720 TDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRI 777
+DVNDN+PV D L + +N + +V A D D G NG + YSL N F
Sbjct: 3020 SDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLD 3079
Query: 778 TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 837
+G + T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y
Sbjct: 3080 PESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYN 3137
Query: 838 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 895
V EN + +++A D D+G N V Y + + F++ +G + L + LD E
Sbjct: 3138 TCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE 3196
Query: 896 AFPDQEASITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
Q++S V A D G + TVT+ V D+ND PPVF +R Y V D G
Sbjct: 3197 ----QQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPG 3252
Query: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 1014
T + V+A D R + Q F++ +G + L+ E F
Sbjct: 3253 TQVLAVFATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRF 3307
Query: 1015 KLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAA 1073
LVV A D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A
Sbjct: 3308 YLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAE 3366
Query: 1074 AI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
+ N I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA
Sbjct: 3367 DVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------V 3419
Query: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
+ +P+ S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ +
Sbjct: 3420 DSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNG 3479
Query: 1190 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
I+ +E E FV++ + G++++A++F + + V A D
Sbjct: 3480 PPFSFSILSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 308 bits (789), Expect = 3e-83
Identities = 329/1188 (27%), Positives = 543/1188 (45%), Gaps = 140/1188 (11%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
Query: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
Query: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
Query: 380 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
+D SG +D E+ + D + + + + +T +DRE +Y ++ A
Sbjct: 1070 ED------SG---RDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
Query: 496 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
D V + V I+V D NDN P E Y V + SVIQ+ A D D SN
Sbjct: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
Query: 554 GEITYEILVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSIC 611
++TY I G Q F IN TGLIT ++ + L V D P ++ S
Sbjct: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STI 1238
Query: 612 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIEN 666
V ++VL N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +
Sbjct: 1239 WVVVQVLDENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVD 1297
Query: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
G+ F + TG+++ K S D IL I A D GRP +STA ++I
Sbjct: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
Query: 726 APV---FD-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 779
+P+ FD P+ N +V+E + + V + P N + + + GNF++ F
Sbjct: 1356 SPIPLTFDEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEK 1410
Query: 780 N-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 838
G+I A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V
Sbjct: 1411 GVGTIVIAKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDV 1467
Query: 839 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYE 895
+ E++ T ILQIEA D D +SY + S F + P TG L LD+E
Sbjct: 1468 TISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHE 1527
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 955
A +I + F + A V V V+D ND+ P F+ +Y+ V A G+
Sbjct: 1528 AQDKHILNIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGS 1583
Query: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI 1013
+ V A D D G A + ++ ++F++E V+ + + +EP TT+
Sbjct: 1584 AVLQVTALDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTM 1634
Query: 1014 --FKLVVVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVI 1070
F L + D G P MS++A V+I V + P+F ++Y+ V+E GT V +I
Sbjct: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILI 1693
Query: 1071 SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLAN 1130
SA + +++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1694 SAIS-QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN 1752
Query: 1131 LRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDK 1183
A V I+I DEN++ PVF Y G +SE A + S L ++ATD
Sbjct: 1753 ---------ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803
Query: 1184 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1243
D+ +++ Y+++ K+ F V++ TG I+T + ++F F V D
Sbjct: 1804 DSNRNALLVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
Query: 1244 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1291
L+ ++ V +++++V N P + + + + +L YV ++
Sbjct: 1861 LTAESPV------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
Score = 270 bits (691), Expect = 7e-72
Identities = 330/1200 (27%), Positives = 515/1200 (42%), Gaps = 173/1200 (14%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 254
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
Query: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
L V + ++ P VP + + P TY +VT + +D
Sbjct: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TY---------------AVVT--VDDLDD 292
Query: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 371
N + S SI+ G P D E + E D F ++L ++
Sbjct: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 372 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
A +D G P A ++I + F Y I E +P G ++
Sbjct: 347 A-KDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVA--------- 396
Query: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTY 489
IV L + DV P +D ++ +N + + + +P++ +++ Y
Sbjct: 397 -IVKLSPEPIDVEYKLSPGED-AVYFKINPRSGL-----------IVTARPLNTVKKEVY 443
Query: 490 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
+T +G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D
Sbjct: 444 KLEVTNKEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD 500
Query: 550 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRN 608
+G NG ITY I F+IN+ TG+I+ ++ Y V+A+D P R
Sbjct: 501 KGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHE 559
Query: 609 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENG 667
S V I + N+ S P F ++ IS VG + + A D E + + Y I +G
Sbjct: 560 SEVNVTIRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
Query: 668 DPQRVFNLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----- 720
+ F L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 619 NELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVS 677
Query: 721 ---------------------------------------DVNDNAPVFDPYLPRNLSVVE 741
+N P FD P +++V E
Sbjct: 678 SKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKE 737
Query: 742 E-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYY 797
+ A + ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y
Sbjct: 738 DLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLY 797
Query: 798 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 857
L + D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D
Sbjct: 798 LLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
Query: 858 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--I 913
DLG+N V+Y + + + FA++ TG + + LD E+ +A+ + +EA D
Sbjct: 858 KDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAE 911
Query: 914 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 973
G + T+ V + D+ND P F Y V D GT I + E DP
Sbjct: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGG 969
Query: 974 RVRYR-VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSS 1031
+VRY V+D FE+++ SG + L+ E + L V A D G PV +SS
Sbjct: 970 QVRYSLVNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSV 1024
Query: 1032 ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVY 1081
+ V++ V LH P F V E + GT V ++A + + I Y
Sbjct: 1025 SFVEVEVVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080
Query: 1082 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
SI G+ F I++ +GVI LD ET SY L V A VV +T +
Sbjct: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIE 1133
Query: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
VYIE++D N++ P+ + Y V E++ SV++++A D D+ + + YR+
Sbjct: 1134 VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSG 1190
Query: 1202 EGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
+ F + TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1191 NPQNFFAINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
Score = 268 bits (685), Expect = 4e-71
Identities = 311/1154 (26%), Positives = 492/1154 (42%), Gaps = 122/1154 (10%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
SD + YSIL G F M ++ ++L + + L +
Sbjct: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
Query: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
Query: 438 IEDVPPSGVPTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSIT 494
T + +ND+ F + G + + +DRE + + +
Sbjct: 2525 --------PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVR 2573
Query: 495 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
A DG + V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N
Sbjct: 2574 ALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANS 2633
Query: 555 EITYEILVGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 610
ITY + A D + I+ G + + + V+A D P ++S+
Sbjct: 2634 RITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSL 2691
Query: 611 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-P 669
VYI VLPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P
Sbjct: 2692 IPVYIHVLPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERP 2748
Query: 670 QR----VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVN 723
+ +F + + TG + L K LDRE++ + + A+ + D T V+I V D+N
Sbjct: 2749 ENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLN 2808
Query: 724 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRI 777
DN PVF+ + + + QV+A D D G NGQV YSL + + F I
Sbjct: 2809 DNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI 2868
Query: 778 TSN-GSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNST 835
SN G I T L+ E + VVA+D G ST ++++V DI+DN+PVF
Sbjct: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
Query: 836 YTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLR 890
Y V+E+ P G + + D D+ VSY I + FAL E + + R
Sbjct: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR 2988
Query: 891 SLDYEAFPDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 948
LD E E I FL + A D ++ T A V V V D+ND PV + Y ++
Sbjct: 2989 PLDRE-----EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLP 3039
Query: 949 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1008
D I V A+DAD +RY + + S F ++ +SG + T L+
Sbjct: 3040 EDIPSNKIILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDR 3093
Query: 1009 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
E ++ L+ A D G S+ + IL P F+ + Y ATK +
Sbjct: 3094 ERIPVYSLMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTR 3152
Query: 1069 VISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1125
V + IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 3153 VQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD-- 3209
Query: 1126 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1185
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD
Sbjct: 3210 ----QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265
Query: 1186 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1245
G + + Y LI ++GK F + TG I + + F V A D LS
Sbjct: 3266 GTNAEITY-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALS 3322
Query: 1246 GKADVLVSVVNQLD 1259
A V +++ + D
Sbjct: 3323 AVATVNINLTDVND 3336
Score = 258 bits (658), Expect = 5e-68
Identities = 311/1171 (26%), Positives = 505/1171 (43%), Gaps = 136/1171 (11%)
Query: 86 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 140
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
Query: 141 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 200
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
Query: 201 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 260
+ D EI D +++ + N N+ + T + V
Sbjct: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
Query: 261 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
+DG L P+++ VL P T +P + I I +
Sbjct: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
Query: 316 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 369
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
Query: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
I ++ + + + I++LD N+ P F SY I+E PVG ++
Sbjct: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT--------- 2834
Query: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTY 489
++ A+D D +G T F + T +++ L+ +D E T+
Sbjct: 2835 QVRAIDM---DWGANGQVTYSLHSDSQPEKVMEAFNIDSN--TGWISTLKDLDHETDPTF 2889
Query: 490 TFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 546
TFS+ A D S +V+++V D NDN P F + Y V PG+ V L+
Sbjct: 2890 TFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTW 2949
Query: 547 DADEGS-NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAP 602
D D N +++Y I G +G F + ++ + + ++ Y L + A D
Sbjct: 2950 DRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLF 3009
Query: 603 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS--- 659
+ V + V N+ SP Q+ Y+ + E + ++L + A D + S
Sbjct: 3010 VTQ-----AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGY 3063
Query: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
I Y++ G F L +G L LDRE Y L+ A+DG + +++++
Sbjct: 3064 IRYSL-YGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLIL 3121
Query: 720 TDVNDNAPVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLF 775
DVNDN PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F
Sbjct: 3122 EDVNDNPPVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVF 3178
Query: 776 RI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTN 833
I +S+G I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF
Sbjct: 3179 SIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFER 3238
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS 891
Y V V E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+
Sbjct: 3239 RDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEV 3298
Query: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 951
LDYE +VEA D +ATV + + D+ND PP FS+ +Y +++ DA
Sbjct: 3299 LDYELC----KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDA 3354
Query: 952 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 1011
+ G + + AED D P ++ + + + + F V+ G V + L+ E
Sbjct: 3355 LVGDSVILLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERV 3409
Query: 1012 TIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVI 1070
+ + L+V A D G P MSS+ATV I + + P FT Y + E GT + +
Sbjct: 3410 SGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQL 3468
Query: 1071 SAAAINQ-----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1125
+ +SI+SGNEE+ F + + G++ + YVL VQA
Sbjct: 3469 VVTDRDSFHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA---- 3523
Query: 1126 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1185
+ P + + + + + +E+ H P ED + ++ ATD+D
Sbjct: 3524 ---KDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM 3580
Query: 1186 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLI 1216
Y V+ + L E K F V ++ G I
Sbjct: 3581 --YDVLTFAL----KSEQKSLFKVNSHDGKI 3605
Score = 257 bits (656), Expect = 8e-68
Identities = 304/1203 (25%), Positives = 534/1203 (44%), Gaps = 145/1203 (12%)
Query: 79 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 133
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
Query: 134 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 191
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
Query: 192 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 251
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
Query: 252 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
Query: 310 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Query: 369 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
Query: 429 LRIVALDKDIE--DVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 486
++I A D D + + + +P+ +N T + T T + +DRE+Q
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS----------RKLDREQQ 1217
Query: 487 QTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQ 542
+ +T DG + + V +QV+D NDN P FPE Y + + R G+ + +
Sbjct: 1218 AEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYR 1277
Query: 543 LTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 601
A D DEG N EI+Y I+ G G F I+ TG+++ + G LT++A DN
Sbjct: 1278 AFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNG 1335
Query: 602 PPAERRNSICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS 659
P +++S ++IE + PP + P F + Y+ + E+ RV ++ + +
Sbjct: 1336 RP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTP 1392
Query: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
+ + I G+ F+ + G + + K LD E Y + + +DG + V I V
Sbjct: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKV 1450
Query: 720 TDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NL 774
D NDN P F P + E+ + + Q++ATD D ++ VH S+ + +
Sbjct: 1451 LDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK 1508
Query: 775 FRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
FRI S G +YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN
Sbjct: 1509 FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRS 891
Y V E+ G+ +LQ+ A D D G N Y I + + F + P G +++ +
Sbjct: 1569 PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE 1628
Query: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAP 949
PD F++ PP AT V + V ++ P F + Y+ V
Sbjct: 1629 ------PDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNE 1682
Query: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
+ GT + + A + S + Y V D IF + SG + T+ L+ E
Sbjct: 1683 NVDIGTSVILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYE 1732
Query: 1010 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVG 1068
T+ ++L++ A + M+S+ATV I ++ + P F +Y +SE A ++V
Sbjct: 1733 RTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVR 1789
Query: 1069 VISAAAI-----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVL 1117
+ + + N +VY IV + F +++ TG I LD+ET +
Sbjct: 1790 SLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHF 1849
Query: 1118 RVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
V DS L + + +V IE+ D N++PPVF + + + + VL
Sbjct: 1850 HVHVRDSGSPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVL 1903
Query: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1235
+V ATD D+ + Y L+ EG + F++++ +G++ + +N+ + ++ V
Sbjct: 1904 KVSATDPDSEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVK 1956
Query: 1236 ATD 1238
+D
Sbjct: 1957 VSD 1959
Score = 253 bits (645), Expect = 2e-66
Identities = 283/1101 (25%), Positives = 478/1101 (43%), Gaps = 115/1101 (10%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
P+ A A + I + +N P F YQ + E+ +G ++ L S + L
Sbjct: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVI----LISAISQSTLIY 1703
Query: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
+++D +G+ T +N Y+ V T + +D E +Y I A
Sbjct: 1704 EVKDGDINGIFT--------INPYSGVITTQKA-----------LDYERTSSYQLIIQAT 1744
Query: 497 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDA 548
+ + VNIQ++D NDN P F Y + ++ P +S+++ + A DA
Sbjct: 1745 NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDA 1803
Query: 549 DEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
D N + Y+I+ A+ F ++ +TG I ++ + V D+ P
Sbjct: 1804 DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTA 1863
Query: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAI 664
S V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++
Sbjct: 1864 ESPVEVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSL 1922
Query: 665 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVND 724
G F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D
Sbjct: 1923 MEGSLDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMD 1977
Query: 725 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSI 783
+ F S E N + +V + +N + YS+ N N F+I S +
Sbjct: 1978 SGLHFTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGV 2034
Query: 784 Y--TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 841
T V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+
Sbjct: 2035 IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQ 2094
Query: 842 ENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 901
+ GT I Q+ A D D G N + F ++P +G + L EAF
Sbjct: 2095 VDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDL 2149
Query: 902 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 961
++I + V G P +V + + +N PVF K Y V D TPI ++
Sbjct: 2150 SNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSIN 2209
Query: 962 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1021
A + G + Y + D P F ++ D+G + L+ E T+ +KL + A
Sbjct: 2210 ATSPEGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA- 2260
Query: 1022 DDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQ 1077
D + TV +LV + P + +SE + GT +V + + + N+
Sbjct: 2261 SDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNK 2320
Query: 1078 SIVYSIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
+ Y IV N D F I++ +G+I LD+E VQ +L+V + PS
Sbjct: 2321 MVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPS 2373
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
S+ V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y +
Sbjct: 2374 LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
Query: 1196 IIPPIKEGKEGFVVETYTGLI 1216
+ + F++++ +G+I
Sbjct: 2434 L---SGNDRTSFLMDSKSGVI 2451
Score = 251 bits (640), Expect = 6e-66
Identities = 309/1250 (24%), Positives = 507/1250 (40%), Gaps = 173/1250 (13%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
Query: 258 VDVLDGDDLGPMFL------------PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 305
+ ++D +D P+FL P + + D PL +A + N ++V
Sbjct: 1757 IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDAD----SNRNALLV 1812
Query: 306 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF-FHMHPRTA---ELSLLEPVN-- 359
+++ + G + +I E F FH+H R + +L+ PV
Sbjct: 1813 YQIVESTA--KKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVN 1870
Query: 360 ---RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 416
D + + +A + LP + G +E+L + P +P Y L +
Sbjct: 1871 IEVTDVNDNPPVFTQAVFETILLLPTYVG--VEVLKVSATDPDSEVPPELTYSLMEGSLD 1928
Query: 417 ATISDSLNLTSPLRIVALDKD-------IED--------VPPSGVPTKDPELHLFLNDYT 461
+ DS + ++ L KD + D V D LH + Y+
Sbjct: 1929 HFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYS 1988
Query: 462 SVFTVTQTGITRYL----------------------------------TLLQPVDREEQQ 487
+ + T IT+ T P DREEQ+
Sbjct: 1989 TSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQE 2048
Query: 488 TYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 544
Y + A D ++ + V+V + + D NDN+P F + Y V D PG + Q+T
Sbjct: 2049 LYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
Query: 545 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPP 603
A+D D+G NGE+TY +L G F IN +G + + + Y +T+ A D P
Sbjct: 2108 AIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP 2166
Query: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYA 663
S+ T + N++ P F + Y+ ++E +R+ +L++ AT EG I Y
Sbjct: 2167 -----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYI 2221
Query: 664 IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 723
I +GDP + FN+ TG+L + LD E T Y L I ASD + TV+++V DVN
Sbjct: 2222 IIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVN 2281
Query: 724 DNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI 777
DN P+FD P + + E + V QV + D D+ N VHY + N + F I
Sbjct: 2282 DNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHI 2339
Query: 778 -TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+S+G I TA L+ E+ + L V + D S + + I + D++DN PVF Y
Sbjct: 2340 DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIY 2399
Query: 837 TVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
V E P G + ++A D D + Y I S + F + +G ++L
Sbjct: 2400 ESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQ 2459
Query: 895 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
P +++ F A V + V N Y P FS+ Y V + G
Sbjct: 2460 RMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG 2512
Query: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT-- 1012
T + V A D DP ++ Y + + + F + + +G+VIT L+ E
Sbjct: 2513 TKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTERLDRENPLEG 2566
Query: 1013 IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVIS 1071
+ V A D G ++ TV+++V+ + P+F EYR +++ +G +V +
Sbjct: 2567 DVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG-RGHLVTQVQ 2623
Query: 1072 AA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1124
A N I YS+ S + D I+ G + G + T V+A
Sbjct: 2624 AIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA--- 2680
Query: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
+ +P K + VYI + P F + Y ++ED + ++V ++
Sbjct: 2681 ----VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ 2736
Query: 1185 TGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
+S + E +G FV+E TG IK F F+V AT
Sbjct: 2737 NVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPL-- 2789
Query: 1243 GLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1292
K D++ +V +D++V+ N + E T D + E +P
Sbjct: 2790 ---DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
Score = 243 bits (619), Expect = 2e-63
Identities = 294/1124 (26%), Positives = 475/1124 (42%), Gaps = 177/1124 (15%)
Query: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTF----EIPLMLTGNIVLRKRLNYED-KTRYFVII 237
D+DDG NG+IE V DP D F E + I RK++++E Y + +
Sbjct: 289 DLDDGANGEIESV-SIVAGDPL--DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
Query: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN-TRDCRPL-----TYQAAI 291
QA D+ G L V + N TRD P+ Y +I
Sbjct: 346 QAKDK--------------------GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
Query: 292 PELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE 351
E P + I+ P + ID + + P D +F ++PR+
Sbjct: 386 SEFSPPGVVVAIVKLSP-EPIDVEYKLSPGEDAV----------------YFKINPRSGL 428
Query: 352 LSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILE 411
+ P+N + + L + ++ + A + I I D N+ +P F P Y Y+ E
Sbjct: 429 IVTARPLNTVKKEVYKLEVTNKEGD-----LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 412 SAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE----LHLFLNDYTSVFTVT 467
S PVG TS L + A DKD + +G T L +N +T V + T
Sbjct: 484 SVPVG---------TSVLTVSASDKDKGE---NGYITYSIASLNLLPFVINQFTGVISTT 531
Query: 468 QTGITRYLTLLQPVDREEQ-QTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 523
+ +D E + Y F + A D + V V I++ + NDN+P F +
Sbjct: 532 -----------EELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
Query: 524 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPG 582
++ + D G + ++A+D DE + Y+I+ G + G F +N +G++ +
Sbjct: 581 VACQGVISYDFPVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKS 638
Query: 583 V--EMIVGRTYALTVQAADNAPPAERRNSICTV--------------------------- 613
+ I +AL + A D A+ + +V
Sbjct: 639 LTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLI 698
Query: 614 -------------YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---G 657
+++ N Q P + + E + VGA +L ++A D +
Sbjct: 699 KAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFN 758
Query: 658 DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 716
+ + I +G+ FN+ TG L + +DRE TD Y+L IT D G P +S +
Sbjct: 759 GKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818
Query: 717 IVVTDVNDNAPVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNN 773
I V D NDN+PVF D Y +++++E + QV+A D D G NG+V YS+
Sbjct: 819 INVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ 875
Query: 774 LFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRH--STLTLAIKVLDIDDNSPV 830
F I +S G +Y A +L+RE + Y L + A D A + S +TL + + D++D SP
Sbjct: 876 QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA 935
Query: 831 FTNSTYTVLVEENLPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSL 888
F S+Y+V V E+LP GT I +E D D LG V Y + + + F + +G + L
Sbjct: 936 FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRL 994
Query: 889 LRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMND--YPPVFSKRIYKG 945
+ LDYE ++ V A D + ++ V V V D+N+ + P F G
Sbjct: 995 SKELDYE----KQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
Query: 946 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 1005
V ++ GT + V A D D ++Y + D F ++++SG +
Sbjct: 1051 SVKENSRIGTSVLQVTARDEDSG--RDGEIQYSIRDGS---GLGRFSIDDESGVITAADI 1105
Query: 1006 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1065
L+ E + L V A D G + S+ V I V + T E P V E + K
Sbjct: 1106 LDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDV 1165
Query: 1066 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQ 1120
V I A ++ N+ + Y I SGN ++ F IN TG+I LD E + +
Sbjct: 1166 SVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF---- 1221
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS--VLRV 1178
LEV + + K +T V +++ DEN++ P F +K Y + E R + R
Sbjct: 1222 ---LEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
Query: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222
A D+D G + ++Y I+ +GK F ++ TG++ + F
Sbjct: 1279 FAFDRDEGPNAEISYS-IVDGNDDGK--FFIDPKTGMVSSRKQF 1319
Score = 236 bits (602), Expect = 1e-61
Identities = 294/1140 (25%), Positives = 485/1140 (42%), Gaps = 151/1140 (13%)
Query: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
Query: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
Query: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
Query: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 398
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
Query: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHL--- 455
F SY +LE PVG I + + T DP+L L
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVI------------------------AWLETHDPDLGLGGQ 970
Query: 456 ----FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVN 508
+NDY F + + + + L + +D E+QQ Y ++ A D V S V
Sbjct: 971 VRYSLVNDYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
Query: 509 IQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-Q 565
++V+D N+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+
Sbjct: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL 1088
Query: 566 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 625
G F I+ +G+IT A ++ +Y LTV A D S VYIEV N+ +P
Sbjct: 1089 GRFSIDDESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAP 1146
Query: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL 682
+ Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++
Sbjct: 1147 LTSEPIYYPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLI 1205
Query: 683 -TLGKALDRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
T + LDRE + L +T +DG P ST V + V D NDN P F P + +
Sbjct: 1206 TTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLP 1264
Query: 741 EEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRD 795
E + + + A D D G N ++ YS+ GN + F I + ++ K
Sbjct: 1265 ERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGS 1323
Query: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGT 848
Y L + A D + ST L I+ + SP+ F N +TV+ + +
Sbjct: 1324 YDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIV 1381
Query: 849 TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
++ ++ + L + I F G + + + LD E Q + V
Sbjct: 1382 GVVSVQPANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSV 1433
Query: 909 EAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 966
E D GT +A V +K D ND P FS+ Y ++ D + T I + A D D
Sbjct: 1434 EVTD--GT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD 1488
Query: 967 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
+ V +D + F ++ +G + T L+ E L ++ D P
Sbjct: 1489 EKHKLSYTVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFP 1544
Query: 1027 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVY 1081
+ A V + V + P FT Y V E A G+ V ++A N ++Y
Sbjct: 1545 YRRNLARVIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIY 1603
Query: 1082 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
+I +GN + F I + G+I + D T +VL ++ + + P S TA
Sbjct: 1604 TIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAI 1656
Query: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
V I + +N P F K Y V+E+ + TSV+ + A + T +I +K
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVK 1706
Query: 1202 EGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
+G F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1707 DGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
Score = 184 bits (466), Expect = 9e-46
Identities = 235/986 (23%), Positives = 420/986 (42%), Gaps = 144/986 (14%)
Query: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
Query: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
TS ++ A D DI + E + + + +F+V T + ++L
Sbjct: 174 -------RTSVAQVTATDADI---------GSNGEFYYYFKNKVDLFSVHPT--SGVISL 215
Query: 478 LQPVDREEQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDV 528
++ +E+ Y I A D GV + + V+I+ + N++ PT +++ V
Sbjct: 216 SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-V 272
Query: 529 YVYTDMRPGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM- 585
+ P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 273 PFSLEKEPTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
Query: 586 -----IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 640
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE
Sbjct: 331 QIDWESFPYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEF 388
Query: 641 MRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 700
G V+ ++ + D + Y + G+ F ++ +G++ + L+ + Y L +
Sbjct: 389 SPPGVVVAIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEV 447
Query: 701 TASDGRPDGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATD 755
T +G A V I + D ND+ P++D Y+ ++ V V V A+D
Sbjct: 448 T----NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASD 498
Query: 756 PDAGINGQVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPR 811
D G NG + YS+ + N L + + G I T +L+ E + Y +V A+D G+ +
Sbjct: 499 KDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRH 558
Query: 812 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 871
S + + I++ +++DNSP+F ++ + P G I + A D+D V Y+I S
Sbjct: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
Query: 872 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---- 927
FF L+P +G L L +SL + + + A D P ++V+
Sbjct: 619 NELGFFYLNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKV 676
Query: 928 --------------------------------------VKDMNDYPPVFSKRIYKGM-VA 948
+N P F K + V
Sbjct: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
Query: 949 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1008
D G I + A DAD +V + + D S F ++ ++G++ + ++
Sbjct: 737 EDLPVGANILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDR 791
Query: 1009 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMV 1067
E T ++ L + +D G P SS + I V + P F Q+ Y V+ L + G
Sbjct: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGT 848
Query: 1068 GVISAAA------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
+I A N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A
Sbjct: 849 EIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEA 906
Query: 1122 -DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
D E V T KV+++ D N+ P F Y V ED + T + ++
Sbjct: 907 RDKAESGQQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
D D G + Y L + + F ++ +G I+ + ++ ++ V A D
Sbjct: 961 HDPDLGLGGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD-- 1014
Query: 1241 GKGLSGKADVLVSVVNQLDMQVIVSN 1266
KG V +S V+ ++++V+ N
Sbjct: 1015 -KG----RPVSLSSVSFVEVEVVDVN 1035
Score = 174 bits (441), Expect = 7e-43
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 481 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 539
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 540 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
Query: 600 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 656
N + + +Y+ + N +P + + V ++
Sbjct: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
Query: 657 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 709
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
Query: 710 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 769
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
Query: 770 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
Query: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 886
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
Query: 887 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 944
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
Query: 945 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 996
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
Query: 997 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1038
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
Query: 1039 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1078
L G + P F + V E G + I A + N
Sbjct: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
Query: 1079 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1138
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
Query: 1139 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1198
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
Query: 1199 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1258
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Query: 1259 DMQVIVSNVPPTLVEKKIEDL 1279
+ +P + K +EDL
Sbjct: 929 VNDCSPAFIPSSYSVKVLEDL 949
Score = 166 bits (421), Expect = 1e-40
Identities = 278/1143 (24%), Positives = 463/1143 (40%), Gaps = 176/1143 (15%)
Query: 225 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 284
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
Query: 285 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 344
TY I E TP + VT A D D G Y + F
Sbjct: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
Query: 345 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 397
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
Query: 398 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFL 457
P + ++ + LE P A +V +D D++D G + + +
Sbjct: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDD----GANGEIESVSIVA 305
Query: 458 NDYTSVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQ 510
D F + + G ++L + +R++ Y ++ A D G + + +
Sbjct: 306 GDPLDQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVY 363
Query: 511 VMD-ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG 566
+ + D P F + YDV + PG ++++L+ D + Y++ G
Sbjct: 364 IGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDA 417
Query: 567 -DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 625
F IN +GLI A + + Y L V + A+ T+ IE N
Sbjct: 418 VYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHT 469
Query: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGIL 682
P F Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG++
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVI 528
Query: 683 TLGKALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 739
+ + LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + +
Sbjct: 529 STTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVIS 588
Query: 740 VEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-Y 796
+ + V A D D + GN F + + + K N +++
Sbjct: 589 YDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGN 648
Query: 797 YELVVVATDG------------AVHPRHSTLT-----------LAIKVL----------- 822
+ L + ATDG +H + S+ + LA K+L
Sbjct: 649 FALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNL 708
Query: 823 --------DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 871
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 709 EDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDG 768
Query: 872 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 931
F + TG+L +L +D E +IT +D+ +T+ V+D
Sbjct: 769 NTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDA 824
Query: 932 NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASI 990
ND PVF + Y + + GT I V A D D V Y V D Q
Sbjct: 825 NDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------Q 876
Query: 991 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRF 1047
F + +G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 877 FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF 936
Query: 1048 TQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYV 1103
Y + +L GT++ + + + YS+V+ + F I+ +G I +
Sbjct: 937 IPSSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRL 994
Query: 1104 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFY 1161
+ LDYE + Y L V+A R S S+ + V +E+ D EN H P F
Sbjct: 995 SKELDYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
Query: 1162 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1221
+G V E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADI 1105
Query: 1222 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDL 1279
+ V ATD L +V + V + D + S P ++E +D+
Sbjct: 1106 LDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDV 1165
Query: 1280 TEI 1282
+ I
Sbjct: 1166 SVI 1168
Score = 141 bits (356), Expect = 5e-33
Identities = 142/581 (24%), Positives = 262/581 (45%), Gaps = 69/581 (11%)
Query: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
Query: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
Query: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
Query: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
Query: 431 IVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
I+ + +D++ P + + D + FTV + + + + +DRE Y+
Sbjct: 3361 ILLIAEDVDSQPNGQI-----HFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYS 3413
Query: 491 FSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
+ A D G+ S VNI + D NDN+P F +Y + + G S++QL D
Sbjct: 3414 LLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDR 3473
Query: 549 DEGSNGE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
D NG ++ IL G + + + G++ A + Y L VQA D+ P +
Sbjct: 3474 DSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVS 3533
Query: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIEN 666
++ + + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++
Sbjct: 3534 HTY--IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS 3590
Query: 667 GDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 706
+ + +F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 3591 -EQKSLFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
Score = 102 bits (253), Expect = 4e-21
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 517 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 570
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
Query: 571 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
Query: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 682
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
Query: 683 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 736
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
Query: 737 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 792
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
Query: 793 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 845
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
Query: 846 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 905
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
Query: 906 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 964 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1022
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
Query: 1023 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1079
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
Query: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1128
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 1129 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1162
+ +V SKS N +++ N P F K F
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 1163 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1219
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
Query: 1220 M 1220
M
Sbjct: 787 M 787
Score = 52.0 bits (123), Expect = 5e-06
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 1070 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1127
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
Query: 1128 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1187
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1188 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1242
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Query: 1243 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1281
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 311 bits (798), Expect = 3e-84
Identities = 332/1235 (26%), Positives = 544/1235 (44%), Gaps = 154/1235 (12%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
Query: 378 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
Query: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
D+D +D E+ + D + V T + +DRE Y ++
Sbjct: 1059 HDEDAR---------RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109
Query: 494 TAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551
A D V S + + I+V D NDN P E Y + + SV+Q+ A D D
Sbjct: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
Query: 552 SNGEITYEILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
SN ++ Y+I G QG F I+ TGLI T + ++ + L V DN P +++
Sbjct: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KST 1227
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDS 659
I V +++L N + P+F Q Y + + E + L ++ ATD++
Sbjct: 1228 IARVIVKIL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAE 1286
Query: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
I+Y+IE+G+ F + TG+++ K + I +GRP +ST ++I
Sbjct: 1287 ISYSIEDGNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI-- 1343
Query: 720 TDVNDNAPVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 775
++ P +P +V+E + A + V + +P GI + GN+++ F
Sbjct: 1344 EWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHF 1402
Query: 776 RI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTN 833
+ G+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+
Sbjct: 1403 DVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFST 1458
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLR 890
S Y V++ E+ T ILQI A D D + Y + R P F L P TG L
Sbjct: 1459 SKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSE 1518
Query: 891 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 950
LD+EA + ++T +V D+ + A + V V D ND+ P F+ YKG V
Sbjct: 1519 KLDHEAV--HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYES 1574
Query: 951 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
A G+ + V A D D + V Y ++ + F ++ G + T L+
Sbjct: 1575 AAVGSVVLQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSN 1629
Query: 1011 TTIFKLVVVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1069
+ L+V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+
Sbjct: 1630 QAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGM 1688
Query: 1070 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
++A + S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1689 VTAHS-QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM----- 1742
Query: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATD 1182
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D
Sbjct: 1743 ----AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAAD 1798
Query: 1183 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
D + +++ Y ++ P + F +++ TG I T + S F F V D
Sbjct: 1799 ADKDSNALLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD---- 1851
Query: 1243 GLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV----- 1297
G + + + VI N P + K + + + +L Y G KV+
Sbjct: 1852 --MGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNAT 1904
Query: 1298 ----------VESIGARRHGDAFSLEDYTKCDLTV 1322
+ SI G+ FS+ DY LTV
Sbjct: 1905 DADSSAFSQLIYSITEGNIGEKFSM-DYKTGALTV 1938
Score = 299 bits (766), Expect = 1e-80
Identities = 318/1166 (27%), Positives = 514/1166 (44%), Gaps = 118/1166 (10%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
V + D +D P F R Y+ I T ++ + D
Sbjct: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
Query: 377 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
K + P S N S Q+G L L + +D E + Y FSI A
Sbjct: 2739 KG--NTPES-------------NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILA 2780
Query: 496 FDGVQESEPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 552
+ E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+
Sbjct: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
Query: 553 NGEITYEI----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 608
NG++ Y + V F IN TG IT ++ Y + V A+D+ E+
Sbjct: 2841 NGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQ 2897
Query: 609 SICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYA 663
T ++V + N SPPRF +Y +SE G V+ L TD + + I TY
Sbjct: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYF 2957
Query: 664 IENGDPQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTD 721
I GDP F + + + + K LDRE D Y+L ITA+DG +S A V + V D
Sbjct: 2958 ITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLD 3015
Query: 722 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-S 779
NDN+PV + L + + + Q+ ATD D N ++ Y+ LG+ F++
Sbjct: 3016 ANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPD 3075
Query: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
G + T+ L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y +
Sbjct: 3076 TGELKTSTPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAIT 3133
Query: 840 VEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 897
V EN GT + +++A D D G N + Y + F+++ +G + L + LD E
Sbjct: 3134 VFENTEPGTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL- 3191
Query: 898 PDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGT 955
+A T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT
Sbjct: 3192 ---QAVYTLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGT 3247
Query: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1015
+ VYA D + + Y + F ++ +G V NL+ E + +
Sbjct: 3248 EVLQVYAASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYY 3302
Query: 1016 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1074
L V A D G P +S ATV + V + P F+Q+ Y + + +++ V++ A
Sbjct: 3303 LTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDA 3362
Query: 1075 ---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1131
N I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++
Sbjct: 3363 DGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDN 3415
Query: 1132 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1191
P + NT V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ +
Sbjct: 3416 GSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPP 3475
Query: 1192 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1251
+ I+ E + F V G++ T+ + ++ QV D +GK
Sbjct: 3476 FFFTIVTGNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ-- 3524
Query: 1252 VSVVNQLDMQVIVSNV-PPTLVEKKI 1276
+S + +D++VI ++ PP ++ +I
Sbjct: 3525 LSSLTYIDIRVIEESIYPPAILPLEI 3550
Score = 288 bits (736), Expect = 4e-77
Identities = 310/1178 (26%), Positives = 507/1178 (43%), Gaps = 140/1178 (11%)
Query: 101 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 160
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 219
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
Query: 220 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
Query: 280 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
A+P P E I V P+ + + + + YSI G
Sbjct: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 391
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
Query: 392 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTK 449
D N+ P F SY + E++ +G TS +++ A D D E P +
Sbjct: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSE-------PNR 2316
Query: 450 DPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIV 507
+F N S T ++LL+ +D E+ + +T + A DG S VIV
Sbjct: 2317 GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
Query: 508 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQG 566
+ V D NDN P F + Y+ + G V + A DAD ++ Y IL G
Sbjct: 2377 TVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHK 2436
Query: 567 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
F+I+ TG+IT++ + Y+L + +D S V++ V+ N S P
Sbjct: 2437 HFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-P 2490
Query: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGI 681
F Q Y +E++E + +++ ++ TD GDS +TY I N + F ++E I
Sbjct: 2491 AFLQNEYEVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQI 2548
Query: 682 LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
TL K LDRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 2549 FTLEK-LDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607
Query: 741 EEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRD 795
V +V A+D D G N + Y++ NL +G I T L +
Sbjct: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667
Query: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 855
++ V A D + S + + +K+L + P F+ YT V E++P GT I I A
Sbjct: 2668 FFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA 2727
Query: 856 KDVDLGANVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 913
+ + +PE F + +G L L +SLD+E + SI L
Sbjct: 2728 EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQD 2785
Query: 914 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 973
M + V++ VKD ND PVF Y+ + + G+ + + A DAD
Sbjct: 2786 DHEMVASV-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNG 2842
Query: 974 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSA 1032
+V Y +D Q F + ++G + T L+ E +++ VVA D GE + +SS+A
Sbjct: 2843 QVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTA 2902
Query: 1033 TVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSG 1086
V + V + PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G
Sbjct: 2903 IVDVTVTDVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGG 2961
Query: 1087 NEEDTFGINNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1144
+ F + I +YV PLD E R +Y+L + A + S+ A V +
Sbjct: 2962 DPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEV 3011
Query: 1145 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1204
++ D N++ PV +K Y + ED ++++ ATD D + + + Y L + G
Sbjct: 3012 KVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGA 3067
Query: 1205 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
E F + TG +KT+ ++ + V ATD G+
Sbjct: 3068 EKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
Score = 286 bits (731), Expect = 2e-76
Identities = 315/1163 (27%), Positives = 512/1163 (44%), Gaps = 145/1163 (12%)
Query: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
Query: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 239
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
Query: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 298
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
Query: 299 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 358
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
Query: 359 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI-----------------EILDEN--NQ 396
K L I A P + + + ++L E
Sbjct: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
Query: 397 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLF 456
+ + +S V A I T P I K+ + V S + +L
Sbjct: 691 NKLHNQGEVEDIFFDSHSVNAHI-PQFRSTLPTGIQV--KENQPVGSSVIFMNSTDLDTG 747
Query: 457 LN----------DYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESE 503
N + S F + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 748 FNGKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAA 804
Query: 504 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 563
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 805 WRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD 864
Query: 564 AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNN 622
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N
Sbjct: 865 TD-TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVN 921
Query: 623 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSET 678
+PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ +
Sbjct: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKL 979
Query: 679 TGILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLP 734
+G + + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++
Sbjct: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
Query: 735 RNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 791
+ + + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+R
Sbjct: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDR 1099
Query: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
E +Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++
Sbjct: 1100 ESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV 1159
Query: 852 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLV 908
QIEA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 1160 QIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD 1219
Query: 909 EAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTV 960
G+ P IA V V + D ND P F ++ YK + PD + P+ V
Sbjct: 1220 N-----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV 1274
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
A D D P + + Y ++D F +E +G V ++ I L + A
Sbjct: 1275 IATDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKA 1327
Query: 1021 FDDGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
D+G P SS+ + I + P P +E + V E M+GVIS
Sbjct: 1328 VDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI 1387
Query: 1078 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSK 1136
+ + I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1388 PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL-------- 1439
Query: 1137 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1196
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1440 ---TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSS 1496
Query: 1197 IPPIKEGKEGFVVETYTGLIKTA 1219
P+ K F ++ TG + T+
Sbjct: 1497 RDPLSLKK--FRLDPATGSLYTS 1517
Score = 281 bits (719), Expect = 4e-75
Identities = 274/1034 (26%), Positives = 455/1034 (44%), Gaps = 116/1034 (11%)
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFT 401
F + T L +L P++R+ K+ L I D G P A + LH+ ++D N+ P F
Sbjct: 765 FMIDMETGMLKILSPLDRETTDKYTLNITV-YDLGIPQKAAWRLLHVVVVDANDNPPEFL 823
Query: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
SY + E V + I +++ A DKD+ P H+ + T
Sbjct: 824 QESYFVEVSEDKEVHSEI---------IQVEATDKDL-----------GPNGHVTYSIVT 863
Query: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES----EPVIVNIQVMDANDN 517
T + +T + + +P+DRE Q ++ I A D +E V+V + + D NDN
Sbjct: 864 DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 577
PTF +Y V V D+ G ++ L A D D G +G++ Y +L +G+F ++K +G +
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAV 983
Query: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLE 636
I ++ + Y LTV+A D P +S C V +EV+ N N PP F +
Sbjct: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVS-LSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042
Query: 637 ISEAMRVGAVLLNLQATD---REGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 693
+ E VG++++ + A D R I Y+I +G VF + E TG++ LDREST
Sbjct: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102
Query: 694 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNA-----PVFDPYL----PRNLSVVEEE 743
Y L + A+D G +S + I V DVNDNA PV+ P + P+++SVV
Sbjct: 1103 SHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV--- 1159
Query: 744 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYEL 799
Q++A DPD+ N ++ Y + GN F I + T KL+RE +D + L
Sbjct: 1160 ------QIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHIL 1213
Query: 800 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV-LVEENLP------AGTTILQ 852
V TD P+ + + +K+LD +DN P F Y + L E P +
Sbjct: 1214 EVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYH 1273
Query: 853 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 910
+ A D D G N +SY I F + P TG +S R + A + + ++A
Sbjct: 1274 VIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYD---ILSIKA 1327
Query: 911 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY-KGMVAPDAVKGTPIT-TVYAEDADPP 968
D P +T + ++ ++ P + + ++ P+ + +PP
Sbjct: 1328 VD--NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP 1385
Query: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
G+P D+ S F+V++ +G +I L+ E + + L V A DG +
Sbjct: 1386 GIPL------WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-TDGTTTI 1438
Query: 1029 SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ----SIVYSIV 1084
+ +K++ + P+F+ +Y + A + ++ +A++Q ++Y++
Sbjct: 1439 LTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPE---TEILQISAVDQDEKNKLIYTLQ 1494
Query: 1085 SGNEE---DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
S + F ++ TG +Y + LD+E V +L V++ + VP K N A+
Sbjct: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEA-------VHQHTLTVMVRDQDVPVKRNFAR 1547
Query: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
+ + + D N+H P F Y G V E A + + VL+V A DKD G + + Y I+
Sbjct: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLY-----SIE 1602
Query: 1202 EGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
G G F+++ G IKTA ++ + V ATD +S V + V
Sbjct: 1603 SGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV----- 1657
Query: 1260 MQVIVSNVPPTLVEK----KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDY 1315
I N P K ++ + I VV I GDAF + +
Sbjct: 1658 --TIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPH 1715
Query: 1316 TKCDLTVYAIDPQT 1329
+ +T A+D +T
Sbjct: 1716 SGTIITQKALDFET 1729
Score = 255 bits (652), Expect = 2e-67
Identities = 318/1217 (26%), Positives = 514/1217 (42%), Gaps = 176/1217 (14%)
Query: 123 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 182
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
Query: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 242
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 243 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
L + ++ LTV + ++ P+ L P+ D
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
Query: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 358
+P + DQ N S SI+ G R P + E + + +
Sbjct: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
Query: 359 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 414
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
Query: 415 VGATI--SDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGIT 472
+ ++ S LR V P F +Y T
Sbjct: 382 PNTPVVMVKAIPAYSHLRYVF--------------KSTPGKAKFSLNYN----------T 417
Query: 473 RYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 532
+++L+PV R++ + +T D ++ V ++V+ AN N P F + +Y
Sbjct: 418 GLISILEPVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDE 474
Query: 533 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTY 591
++ G +V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y
Sbjct: 475 NVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVY 534
Query: 592 ALTVQAADNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 650
L ++A+D P R + T+ + L N + P F ++ I + VG + +
Sbjct: 535 TLRIRASDWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 651 QATDR-EGDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGR 706
A D E + Y IE G+ F+L+ +G+L+L ++L + L ITA+DG
Sbjct: 592 SAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGE 651
Query: 707 PDGTSTATVNIVVT-------------------------------------------DVN 723
T +NI V VN
Sbjct: 652 NFAT-PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVN 710
Query: 724 DNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TS 779
+ P F LP + V E + + V + +TD D G NG++ Y++ GN ++ F I
Sbjct: 711 AHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDME 770
Query: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
G + L+RE D Y L + D + + + L + V+D +DN P F +Y V
Sbjct: 771 TGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVE 830
Query: 840 VEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 897
V E+ + I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E
Sbjct: 831 VSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL- 887
Query: 898 PDQEASITFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGT 955
E S+ +EA D P +TV V V +D+ND PP F Y+ V D +GT
Sbjct: 888 -QHEHSLK--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGT 944
Query: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1015
I ++ E DP + +VRY + D + F+V++ SG V L+ E ++
Sbjct: 945 VI--MWLEAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYN 998
Query: 1016 LVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
L V A D G+PV +SS+ V++ V LHP F ++ V E A G++V
Sbjct: 999 LTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVM 1054
Query: 1069 VISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1124
+SA A + I YSI G+ F I TGVI + LD E+ + Y L V A
Sbjct: 1055 TVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQ 1114
Query: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
VV S+ ++YIE++D N++ P + Y + E++ SV++++A D D
Sbjct: 1115 GVV-------PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPD 1167
Query: 1185 TGNYSVMAYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGK 1242
+ + + Y++ +GF + TGLI T+ ++ +V TD+
Sbjct: 1168 SSSNDKLMYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP 1223
Query: 1243 GLSGKADVLVSVVNQLD 1259
S A V+V ++++ D
Sbjct: 1224 PKSTIARVIVKILDEND 1240
Score = 255 bits (651), Expect = 3e-67
Identities = 261/956 (27%), Positives = 432/956 (45%), Gaps = 135/956 (14%)
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
Query: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS 462
+Y+ E+ P+G T+ SL+ P D +G T + N
Sbjct: 466 TAYKAAFDENVPIGTTVM-SLSAVDP-----------DEGENGYVT-----YSIANLNHV 508
Query: 463 VFTVTQTGITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNT 518
F + T ++ + +D E + YT I A D + V+ I + + NDNT
Sbjct: 509 PFAIDH--FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNT 566
Query: 519 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLI 577
P F +I+ + + D+ G+ + ++A+DADE + Y+I G + DF +N +G++
Sbjct: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVL 624
Query: 578 TIAPGVEMIVGRT---YALTVQAADN---------------------------------- 600
++ + +G ++L + A D
Sbjct: 625 SLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLA 684
Query: 601 -----APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 655
A + + ++ + N P L +++ E VG+ ++ + +TD
Sbjct: 685 EKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDL 744
Query: 656 E---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTS 711
+ + YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P +
Sbjct: 745 DTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAA 804
Query: 712 TATVNIVVTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL 768
+++VV D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+
Sbjct: 805 WRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI 861
Query: 769 GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDID 825
+ F I S G + A L+RE++ + L + A D A P+ ST+ + + + D++
Sbjct: 862 VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN 921
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPF 882
DN P F Y V V E+LP GT I+ +EA D DLG S ++R + H F +
Sbjct: 922 DNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKL 979
Query: 883 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPV 937
+G + +++ LD+E ++ V A D P +++ V V V D+N+ +PPV
Sbjct: 980 SGAVRIVQQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
Query: 938 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997
FS + KG V DA G+ + TV A D D +RY + D +F++ E++
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEET 1088
Query: 998 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV 1057
G + T L+ E T+ + L V A D G +SS + I V + T E P +
Sbjct: 1089 GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEI 1148
Query: 1058 SELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETR 1112
E + K V I A ++ N ++Y I SGN + F I+ TG+I LD E +
Sbjct: 1149 MENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQ 1208
Query: 1113 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE----- 1167
++ LEV + + P KS A+V ++I DEN++ P F +KFY + E
Sbjct: 1209 DEHI-------LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD 1261
Query: 1168 ---DARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1218
+AR + V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1262 RERNARR-EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
Score = 249 bits (635), Expect = 2e-65
Identities = 282/1148 (24%), Positives = 489/1148 (42%), Gaps = 137/1148 (11%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Query: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
Query: 437 DIE--DVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
D D + + +P+ ++ T + T T + +DRE+Q + +T
Sbjct: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS----------RKLDREQQDEHILEVT 1216
Query: 495 AFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTA 545
D + I V ++++D NDN P F + Y + + +P + + + A
Sbjct: 1217 VTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
Query: 546 VDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 604
D DEG N EI+Y I G + G F I TG+++ G L+++A DN P
Sbjct: 1277 TDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP- 1333
Query: 605 ERRNSICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 662
+++S ++IE + P + P F + ++ + E+ V A ++ + + + G + +
Sbjct: 1334 -QKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWF 1391
Query: 663 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDV 722
I G+ F++ + TG + + K LD E Y L + A+DG T V I V D
Sbjct: 1392 DITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDT 1449
Query: 723 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRI 777
ND+ P F + + + Q+ A D D ++ Y+L + + FR+
Sbjct: 1450 NDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRL 1507
Query: 778 T-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ GS+YT+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y
Sbjct: 1508 DPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSY 1567
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
V E+ G+ +LQ+ A D D G N V Y I S + + F + P G + + LD
Sbjct: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD- 1626
Query: 895 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
+A +V+A D I +V + V ++ P F+ + Y ++ G
Sbjct: 1627 ---RSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIG 1683
Query: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 1014
+ + V A S V Y + D F++ SG +IT+ L+ E I+
Sbjct: 1684 SFVGMVTAHS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIY 1733
Query: 1015 KLVVVAFDDGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV---- 1067
L++ G + S +LV E P F Q EY +SE A+ ++V
Sbjct: 1734 TLII----QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDR 1788
Query: 1068 ---GVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
VI AA N +VY IV + F I++ TG I+ LDYE + + VQ
Sbjct: 1789 NVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQ 1848
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
+ A V + + D N+ PPVF K Y + V+ V A
Sbjct: 1849 VHDMGTPRL-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNA 1903
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIAT 1237
TD D+ +S + Y + EG + E ++ KT L RS ++ V A+
Sbjct: 1904 TDADSSAFSQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRAS 1955
Query: 1238 DDYGKGLS 1245
D GL+
Sbjct: 1956 DGRFAGLT 1963
Score = 242 bits (617), Expect = 3e-63
Identities = 294/1157 (25%), Positives = 499/1157 (43%), Gaps = 139/1157 (12%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 374
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
Query: 375 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
V P G+P + +Y S F V + T + + +P+D E++ Y ++
Sbjct: 1382 -------VEPPGIPL---WFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTV 1429
Query: 494 TAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
A DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE
Sbjct: 1430 EATDGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--K 1486
Query: 554 GEITYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
++ Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 1487 NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFA 1546
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 666
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+
Sbjct: 1547 RIVVNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES 1603
Query: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
G+ F + G + K LDR + Y L++ A+D G P + +V I VT ++
Sbjct: 1604 GNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNA 1663
Query: 726 APVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-S 779
+P F + SV E +FVG V A V Y + GN + F I
Sbjct: 1664 SPKF---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPH 1715
Query: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
+G+I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L
Sbjct: 1716 SGTIITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGL 1773
Query: 840 VEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 890
+ E+ + +L I A D D +N + Y I P V +FA+ TG + +
Sbjct: 1774 ISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVL 1833
Query: 891 SLDYEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 947
SLDYE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 1834 SLDYE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASL 1888
Query: 948 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1007
KG + TV A DAD S++ Y + + F ++ +G + V
Sbjct: 1889 LLPTYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNT 1941
Query: 1008 EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTM 1066
+ + ++L V A D + +VKI V E +FTQ+ Y V E +T+
Sbjct: 1942 TQLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAET 1997
Query: 1067 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1123
+ VI+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++
Sbjct: 1998 LAVITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEA 2046
Query: 1124 LEVVLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
+VV+ S A V ++ ++D+N++ PVF Y V D + + V A
Sbjct: 2047 FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAV 2106
Query: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDY 1240
D+D+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 2107 DRDSGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGG 2160
Query: 1241 GKGLSGKADVLVSVVNQ 1257
S + V ++V+N+
Sbjct: 2161 NPAFSAEVIVPITVMNK 2177
Score = 242 bits (617), Expect = 3e-63
Identities = 290/1203 (24%), Positives = 498/1203 (41%), Gaps = 164/1203 (13%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 195
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 196 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
Query: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
Query: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
Query: 376 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
Query: 433 ALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 492
P +P+ ++ + V + T T P DRE+Q+ +
Sbjct: 2010 ---------EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVV 2050
Query: 493 ITAFDGVQESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 547
+ +E +P V+V + V D NDN P F + Y V D G + +TAVD
Sbjct: 2051 VEV---TEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107
Query: 548 ADEGSNGEITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
D G NGE+ Y + +G G+ + K L T+ + Y +TV A D
Sbjct: 2108 RDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDG 2159
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
PA I + + N++ P F + YS EI+E+++V + ++++QA EG +
Sbjct: 2160 GNPAFSAEVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKV 2214
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Y+I +GDP F ++ TG++ + LD E+ Y L I A+D + V+I+V
Sbjct: 2215 FYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVD 2274
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NN 773
D+NDN PVF ++ +V EA+ V QV+ATD D+ N + Y + GN ++
Sbjct: 2275 DINDNPPVF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHD 2331
Query: 774 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 832
F + S+ + + ++ L+ E + + V A DG + S + + + V D++DN P+F
Sbjct: 2332 HFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
Query: 833 NSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLR 890
Y + E+ P G + ++A D D + Y I S F + TG ++L
Sbjct: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN 2451
Query: 891 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 950
+ P +++ F V V V N + P F + Y+ +A +
Sbjct: 2452 LHRHALKPFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAEN 2504
Query: 951 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 1010
A T + V D D G+ + V+D + F + E G++ T L+ E
Sbjct: 2505 APLHTLVMEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRET 2558
Query: 1011 TT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
+ + ++A D G V + V IL P+F +Y + A KGT V
Sbjct: 2559 PAEKVISVRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVV 2616
Query: 1069 VISAA----AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRV 1119
+ A+ N I Y+I + +E ++ IN ++GVI L+ E T +V V
Sbjct: 2617 KVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV 2676
Query: 1120 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1179
S PSK + VY++I P F + FY VSED + T + ++
Sbjct: 2677 DNGS----------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR 2726
Query: 1180 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA--- 1236
A T YS++ P E FV++ +G +K + +++F ++A
Sbjct: 2727 AEHSGTVLYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCT 2783
Query: 1237 TDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKV 1296
DD+ + DV + V + D + + P + ++ E +PG
Sbjct: 2784 QDDH--EMVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSR 2827
Query: 1297 VVE 1299
V++
Sbjct: 2828 VIQ 2830
Score = 217 bits (552), Expect = 9e-56
Identities = 281/1203 (23%), Positives = 497/1203 (41%), Gaps = 126/1203 (10%)
Query: 116 IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 173
++++ V+ + K V + Y EV +V + N + P F TV E PVG+ + T
Sbjct: 996 VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 174 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 233
A D D +G+I Y I+ D + F+I TG I RL+ E + Y
Sbjct: 1056 -----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIETSDRLDRESTSHY 1105
Query: 234 FVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE 293
++ + A D+ ++ + ++V D +D P V P +
Sbjct: 1106 WLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME------------ 1150
Query: 294 LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELS 353
+P++++ + I+A D D S ++Y I G P+ FF +HP+T ++
Sbjct: 1151 -NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLIT 1197
Query: 354 LL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 412
++R+ + L + + P A + ++ILDEN+ P F Y+ + E
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER 1257
Query: 413 APVGATISDSLNLTSPL-RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGI 471
+ PL ++A DKD +D N++ F +TG+
Sbjct: 1258 EKPD---RERNARREPLYHVIATDKDEGPNAEISYSIEDG------NEHGKFFIEPKTGV 1308
Query: 472 TRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVY 531
+ + SI A D + + + + + P+ IS++ +
Sbjct: 1309 VSSKRFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFF 1363
Query: 532 T-DMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGR 589
T + D V + V + E + ++I G F ++K TG I +A ++
Sbjct: 1364 TFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
Query: 590 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 649
Y LTV+A D + V+I+V+ N+ P+F Y + I E +L
Sbjct: 1424 NYNLTVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPETEILQ 1477
Query: 650 LQATDR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYILIITASD- 704
+ A D+ E + + Y +++ DP + F L TG L + LD E+ ++ L + D
Sbjct: 1478 ISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQ 1537
Query: 705 GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 764
P + A + + V+D ND+AP F + + V QV A D D G N +V
Sbjct: 1538 DVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEV 1597
Query: 765 HYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 821
YS+ GN N F I GSI TA +L+R + Y+L+V ATD P ++ I V
Sbjct: 1598 LYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV 1657
Query: 822 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHP 881
D+ SP FT+ Y+V + E + G+ + + A ++V Y I+ F ++P
Sbjct: 1658 TIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNTGDAFDINP 1714
Query: 882 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKDMNDYPPVF 938
+G + ++LD+E P + I GT G++T T + ++D ND PVF
Sbjct: 1715 HSGTIITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVF 1765
Query: 939 SKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQFPYPASIF 991
+ Y G+++ A + + T + A DAD A V + V+ P + F
Sbjct: 1766 MQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE----PSVHTYF 1820
Query: 992 EVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHPGEIPRFTQ 1049
++ +G + T ++L+ E T+IF V D G P + + +A V + V+ + P
Sbjct: 1821 AIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFA 1880
Query: 1050 EEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNG 1105
+ + KG V ++A + S ++YSI GN + F ++ TG + V
Sbjct: 1881 KPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQN 1940
Query: 1106 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1165
+ R+ Y L V+A + V I +++ F + Y V
Sbjct: 1941 TT--QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFTQDVYSAVV 1988
Query: 1166 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK-TAMLFHN 1224
E++ ++ + A + Y ++ P + F + +G++ T F
Sbjct: 1989 KENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLSTTGTPFDR 2041
Query: 1225 MRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILD 1284
++ F V T+++ V V V +Q D + N+P V K ++ ++
Sbjct: 2042 EQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI- 2100
Query: 1285 RYV 1287
RYV
Sbjct: 2101 RYV 2103
Score = 177 bits (449), Expect = 8e-44
Identities = 220/884 (24%), Positives = 369/884 (41%), Gaps = 132/884 (14%)
Query: 481 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 539
++RE + YT + A + E V +QV+D ND P F SY V + + S
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
Query: 540 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + AAD
Sbjct: 168 IARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAAD 226
Query: 600 NAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 654
+ I TV+IE N +P + E+ V ++
Sbjct: 227 RGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQG 284
Query: 655 REGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD-GR 706
GD + +I GD R F S+ + +G +D +S Y L + A D G
Sbjct: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDKGT 343
Query: 707 PDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKATDP 756
P S+ V V + PV + P N VV +A ++
Sbjct: 344 PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFK 403
Query: 757 DAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT 816
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 404 STP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKASTK 448
Query: 817 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 874
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I + +
Sbjct: 449 VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN--LN 506
Query: 875 HF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIVKD 930
H FA+ FTG +S +LDYE P T + A D Y +AT+T+ +
Sbjct: 507 HVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL--NN 561
Query: 931 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 990
+ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---ELDF 614
Query: 991 FEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF--------- 1021
F + +SG + IT + T ++ + VA
Sbjct: 615 FSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQC 674
Query: 1022 -DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATKGT 1065
+ G M + ++ LH GE IP+F V E G+
Sbjct: 675 EETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGS 734
Query: 1066 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 735 SVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY------ 788
Query: 1122 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+AT
Sbjct: 789 -TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEAT 847
Query: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYG 1241
DKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 848 DKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
Query: 1242 KGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1281
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 903 E----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
Score = 164 bits (415), Expect = 7e-40
Identities = 187/693 (26%), Positives = 297/693 (42%), Gaps = 106/693 (15%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 196
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
Query: 197 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
Query: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 308
R ++ + + D +D P F +A P T E P +
Sbjct: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
Query: 309 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
Query: 369 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 425
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
Query: 426 TSPLRIVALDKDIEDVPPSGVPTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVD 482
T L++ A +DIE + E+ + N++ ++TG + +++ +D
Sbjct: 3247 TEVLQVYAASRDIE---------ANAEITYSIISGNEHGKFSIDSKTGA---VFIIENLD 3294
Query: 483 REEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
E Y ++ A DG S + VN+ V D NDNTP F + +Y + D SV
Sbjct: 3295 YESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV 3354
Query: 541 IQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
I + A DAD SN I Y I+ G QG F I+ G + + ++ Y LTVQA+D
Sbjct: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
Query: 600 NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE--- 656
N P R + TV I+V N+ +P F + YS+ I E VG +L L TD +
Sbjct: 3415 NGSPP--RVNTTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSH 3471
Query: 657 -GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT 714
G + I G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S
Sbjct: 3472 NGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTY 3530
Query: 715 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNN 773
++I V + + P P S EE + +G++ ATD D + + YSL +N
Sbjct: 3531 IDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDN 3588
Query: 774 LFRITSNGSIYTAVKLNREVRDYYELVVVATDG 806
LF ++S G A K ++ Y L V TDG
Sbjct: 3589 LFSVSSTGGKLIAHK-KLDIGQYL-LNVSVTDG 3619
Score = 138 bits (347), Expect = 5e-32
Identities = 152/593 (25%), Positives = 257/593 (43%), Gaps = 71/593 (11%)
Query: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
Query: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
Query: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
Query: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
Query: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
+A L A +++ + D N+ +P F+ +Y I E A + ++ +
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV---------IT 3356
Query: 431 IVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
++A D D PS + +H + D + T + + + + +DRE YT
Sbjct: 3357 VMADDAD----GPS-----NSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYT 3407
Query: 491 FSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
++ A D VNI V D NDN P F +Y V + + G SV+QL D
Sbjct: 3408 LTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDE 3467
Query: 549 DEGSNG-EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
D NG + I+ G G++ + ++ Y L V+ ADN P +
Sbjct: 3468 DSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QL 3525
Query: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIEN 666
+S+ + I V+ + P P ++ E G V+ + ATD++ D++TY++
Sbjct: 3526 SSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL-- 3582
Query: 667 GDPQ--RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 717
DPQ +F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 3583 -DPQMDNLFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
Score = 126 bits (317), Expect = 2e-28
Identities = 141/560 (25%), Positives = 246/560 (43%), Gaps = 62/560 (11%)
Query: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
+I+ R+ A D DI + E + D T +F + T + + L
Sbjct: 167 SIA---------RVSATDADIGT---------NGEFYYSFKDRTDMFAIHPT--SGVIVL 206
Query: 478 LQPVDREEQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDV 528
+D E + Y I A D G+ + V+I+ AN+ P ++
Sbjct: 207 TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSP 264
Query: 529 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----V 583
D P +++ T D D+G+NG+I +V GD + T + PG V
Sbjct: 265 SEL-DRDPAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKV 317
Query: 584 EMIVGRT-------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 636
+ I G Y LT+QA D P + +S+ +++ P P +F + +Y E
Sbjct: 318 KAIGGIDWDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAE 375
Query: 637 ISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 696
ISE ++ ++A + Y ++ + F+L+ TG++++ + + R+ +
Sbjct: 376 ISEFAPPNTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHF 434
Query: 697 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 756
L +T SD + ++ V + V N N P F + V + A DP
Sbjct: 435 ELEVTTSDRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDP 490
Query: 757 DAGINGQVHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHS 813
D G NG V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R
Sbjct: 491 DEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
Query: 814 TLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 872
LA I + +++DN+P+F + +L G I + A D D V Y+I +
Sbjct: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGN 610
Query: 873 VKHFFALHPFTGELSLLRSL 892
FF+L+P +G LSL RSL
Sbjct: 611 ELDFFSLNPNSGVLSLKRSL 630
Score = 118 bits (295), Expect = 6e-26
Identities = 132/499 (26%), Positives = 222/499 (44%), Gaps = 39/499 (7%)
Query: 766 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
Y LG+F L T G+ TA+ LNREV+D+Y L+V A + + T + ++VLD +
Sbjct: 88 YILGDFCFLRIRTKGGN--TAI-LNREVKDHYTLIVKALEKNTNVEART-KVRVQVLDTN 143
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
D P+F+ ++Y+V + EN T+I ++ A D D+G N + + FA+HP +G
Sbjct: 144 DLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGV 203
Query: 886 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYK 944
+ L LDY E I +YG+ +A +TV ++ N+ PV I
Sbjct: 204 IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPV----ITA 259
Query: 945 GMVAPDAVKGTP---ITTVYAEDADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRV 1000
++P + P I TV D G AS D + QF S +E +
Sbjct: 260 VTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP----GEIPRFTQEEYRPPP 1056
I ++ + P + L + A D G P SS V I V P G + +F ++ YR
Sbjct: 320 IGGIDWDSHPFG-YNLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPV-KFEKDVYR-AE 375
Query: 1057 VSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1116
+SE A T V ++ A + Y S + F +N TG+I + P V
Sbjct: 376 ISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEP---------V 426
Query: 1117 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
R QA E+ + + + KV +++ N++PP F + Y E+ + T+V+
Sbjct: 427 KRQQAAHFEL---EVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
Query: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA-MLFHNMRRSYFKFQVI 1235
+ A D D G + Y + F ++ +TG + T+ L + + + ++
Sbjct: 484 SLSAVDPDEGENGYVTYSI----ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539
Query: 1236 ATDDYGKGLSGKADVLVSV 1254
A+ D+G + +VL ++
Sbjct: 540 AS-DWGLPYRREVEVLATI 557
Score = 103 bits (256), Expect = 2e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 623 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 677
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Query: 678 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 727
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
Query: 728 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 781
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
Query: 782 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 836
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 888
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 889 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 945
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
Query: 946 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 1004
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
Query: 1005 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1064
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
Query: 1065 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1119
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
Query: 1120 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1233
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
Query: 1234 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1277
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 305 bits (782), Expect = 2e-82
Identities = 338/1179 (28%), Positives = 534/1179 (45%), Gaps = 139/1179 (11%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTT--IFTGFSGDNGATDIDDGPNGQIEYVIQ 197
I++ D D P F + Y + E +P GTT I T D G P G I
Sbjct: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR------PRG-----IG 272
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT-----T 252
Y +N F + ++G + L L+ E+ I + LN+ RT
Sbjct: 273 YTIVSGNTNSIFALDY-ISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDRTPSDATV 330
Query: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
TTT + V+D +D P F N+ + Y AI EL P+ IQ +
Sbjct: 331 TTTFNILVIDINDNAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVV 374
Query: 313 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKF 366
D+D N+ S + LVG + F + P + + + + P++ + ++
Sbjct: 375 DKDENLGLNS----MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRY 427
Query: 367 DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 426
D + A + + +A + I +++EN+ P F+ P Y + E+ VG T
Sbjct: 428 DFDLFANESVPDHV-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------T 477
Query: 427 SPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 486
S L ++A D D E+ F +D F++ + T + L+ +D E
Sbjct: 478 SVLTVLATDNDAGTFG---------EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELI 526
Query: 487 QTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 546
Q +T +I A DG E V I V+D NDN PTF + +Y + + +++L A
Sbjct: 527 QRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRAT 586
Query: 547 DADEGSNGEITYEIL----VGAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADN 600
D D N +ITY I+ G+ D + + G+I+++ + E I LTV A D
Sbjct: 587 DEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDA 646
Query: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--- 657
P NS V IEV N+ +PP F + Y + + E + GA +L L ATD +
Sbjct: 647 GNPP--LNSTVPVTIEVFDEND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE 703
Query: 658 ---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTS 711
+SI Y++E G Q F ++ +G +T LDRE+ YILI+ A DG T
Sbjct: 704 YGQESIIYSLE-GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
Query: 712 TATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGN 770
ATVNI + D+NDN P + P +++VE ++ V V A DPD G NG + YS+
Sbjct: 761 IATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP 819
Query: 771 FNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDGAVHPRHST--LTLAIK 820
N + + S G I T L+RE D +E +VV TD P +T T+ +
Sbjct: 820 PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVN 879
Query: 821 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 878
+LD++DN P F N + V E +PAG +I Q+ A D+D G N VSYR+ + F
Sbjct: 880 LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
Query: 879 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 938
++ +G + LD E + + + A D +T+T+ V D+ND P F
Sbjct: 940 INSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
Query: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998
+Y V+ D + + + D D GL A + Y + F V
Sbjct: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDA 1050
Query: 999 RVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRP 1054
V T V L+ E T + L++ A D+G PV + +ATV + VL + P F Q Y
Sbjct: 1051 VVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
Query: 1055 PPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDY 1109
V E +G + + A ++ + Y I+ GN + F I+ G++ PLD
Sbjct: 1110 S-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR 1168
Query: 1110 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSED 1168
E +S+VL V+A + ++ P +S+ +V + ++D N+ PVF ++ Y G+ E
Sbjct: 1169 ERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRET 1221
Query: 1169 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRR 1227
A + TSV+ V+ATD+D+G+ ++ YR++ G EG F ++ TGLI T +
Sbjct: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETK 1276
Query: 1228 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
+ + V ATD G V ++++N+LD V SN
Sbjct: 1277 TSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
Score = 295 bits (754), Expect = 4e-79
Identities = 317/1180 (26%), Positives = 516/1180 (43%), Gaps = 122/1180 (10%)
Query: 101 LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 154
+ +T +LDR+ P + IVV V C + V + + D NDN PTF++
Sbjct: 833 IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
Query: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL- 213
+ A V E P G +I+ A D+D+G NG + Y + P + +
Sbjct: 893 LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRM------PVGMPRMDFLIN 941
Query: 214 MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPC 273
+G +V L+ E Y + + A+D +++T+TLT+ VLD +D P F P
Sbjct: 942 SSSGVVVTTTELDRERIAEYQLRVVASDAG---TPTKSSTSTLTIHVLDVNDETPTFFPA 998
Query: 274 VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILV 333
V Y ++ E P E + + D D + + Y I
Sbjct: 999 V------------YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITG 1036
Query: 334 GTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEIL 391
G + F + R A + + ++R+ + L+++A + G A + + +L
Sbjct: 1037 GNVDGK---FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1093
Query: 392 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDP 451
D N+ P F SY+ + E P G +I L++ A D D +
Sbjct: 1094 DVNDNRPIFLQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWY----- 1139
Query: 452 ELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIV 507
+ ++ + F + G+ + +P+DRE ++ + A++ G S V V
Sbjct: 1140 --RILHGNHGNNFRIHVSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRV 1194
Query: 508 NIQVMDANDNTPTFPEISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQG 566
+ V D ND P F + Y + G SVI + A D D G G + Y IL GA+G
Sbjct: 1195 IVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEG 1254
Query: 567 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
F I+++TGLI ++ +Y + V A D APP + C+VYI +L +++
Sbjct: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV- 1311
Query: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGIL 682
+F Y I E + +G ++ +QA + + ITY A + + +F + TG++
Sbjct: 1312 QFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVI 1371
Query: 683 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
T+ +DRE D Y L + A DG P ST V I V D NDN+P FD +S+ E+
Sbjct: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
Query: 743 -EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRD 795
V VKA DPDAG NGQV +SL GN F I S G ++ A L+RE D
Sbjct: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELD 1491
Query: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIE 854
+Y L VVA+D PR L + +LDI+DN PV + Y V V EN+ GT ++Q+
Sbjct: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
Query: 855 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAF 911
A D D+G N +SY I F + +GE++ A PD+E S LV
Sbjct: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATV 1606
Query: 912 DIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPP 968
+ GT T V V + D ND P+F + Y+ ++ PD + T + T+ A D D
Sbjct: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG 1665
Query: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
P V Y + + F ++ G + L+ E + ++V D P++
Sbjct: 1666 --PNGTVTYAIVAGNI---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
Query: 1029 S----SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSI 1079
S S+ TV + V + +P F ++ P V+E G V A + N +
Sbjct: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQV 1779
Query: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1139
YSI+ G+ F I+ + GV+ V ++ + T + +L + + +P S+T
Sbjct: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSST 1834
Query: 1140 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1199
V I + D N++ PV +SE++ + + V V A+D D+G + + + +
Sbjct: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---T 1891
Query: 1200 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1239
+ F + TG++ R +K + D+
Sbjct: 1892 AGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
Score = 288 bits (737), Expect = 3e-77
Identities = 320/1103 (29%), Positives = 487/1103 (44%), Gaps = 112/1103 (10%)
Query: 133 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
Query: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Query: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
Query: 313 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
Query: 372 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
Query: 428 PLRIVALDKDIEDVPPSG---VPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 484
PL I +DKD E++ + V H F+ TSV Q + + P+D E
Sbjct: 368 PLFIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSV----QGKADIRIRVAIPLDYE 422
Query: 485 EQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543
Y F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ +
Sbjct: 423 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Query: 544 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 603
A D D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 483 LATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG-- 539
Query: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSI 660
+ V I VL N+ + P F + Y + E L+ L+ATD + + I
Sbjct: 540 --GEETTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQI 596
Query: 661 TYAIENGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTAT 714
TY+I + + +L E G++++ + LD E Y+ ++ G P ST
Sbjct: 597 TYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVP 656
Query: 715 VNIVVTDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSL 768
V I V D NDN P F Y +SVVE A A V + ATD D GQ + YSL
Sbjct: 657 VTIEVFDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 713
Query: 769 GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDID 825
+ FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+
Sbjct: 714 EG-STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 883
DN P + ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ T
Sbjct: 773 DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTT 830
Query: 884 GELSLLRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVF 938
G++ + LD E EA + + PP ATV V + D+ND P F
Sbjct: 831 GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
Query: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998
+ V G I V A D D GL V YR + P F + SG
Sbjct: 891 QNLPFVAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSG 945
Query: 999 RVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPV 1057
V+T L+ E ++L VVA D G P SS++T+ I VL E P F Y
Sbjct: 946 VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVS 1005
Query: 1058 SELATKGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1114
++ + +V + + +N + Y I GN + F + V+ LD ET +
Sbjct: 1006 EDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA 1065
Query: 1115 YVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFT 1173
Y+L ++A + N V + + TA V++ + D N++ P+F + Y V ED
Sbjct: 1066 YMLILEA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
Query: 1174 SVLRVKATDKDTGNYSVMAYRLI 1196
S+L++KATD D G + + YR++
Sbjct: 1120 SILQLKATDADEGEFGRVWYRIL 1142
Score = 283 bits (723), Expect = 1e-75
Identities = 341/1265 (26%), Positives = 535/1265 (42%), Gaps = 150/1265 (11%)
Query: 44 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
Query: 100 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
Query: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Query: 213 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
Query: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
+F +PL Y ++ E N + T + + D + + +
Sbjct: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
Query: 329 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Query: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
+LD N+ P F +Y G + E+ P ++T +R+ A D ED PP+ T
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATD---EDSPPNNQIT 597
Query: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP---- 504
Y + G+ +++ +P+D E+ +T + P
Sbjct: 598 YSIVSASAFGSYFDISLYEGYGV---ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNST 654
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEIL 561
V V I+V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y +
Sbjct: 655 VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
Query: 562 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 621
Q F IN +G IT ++ Y L V+A D ++ I TV I +L N
Sbjct: 715 GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
Query: 622 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSET 678
+ P + Y + + E + + + A D E ++ Y+I+ P + ++L+ T
Sbjct: 773 DNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
Query: 679 TG-ILTLGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPV 728
TG I T LDRE+ D R I++ GRP TS+ATV + + D+NDN P
Sbjct: 830 TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
Query: 729 FDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIY 784
F LP V+E A + QV A D D G+NG V Y + G F I +S+G +
Sbjct: 890 FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
Query: 785 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844
T +L+RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++
Sbjct: 949 TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
Query: 845 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902
P ++ + D D+G N +SY I V F++ + + LD E A
Sbjct: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TA 1064
Query: 903 SITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
+ ++EA D G G ATV V V D+ND P+F + Y+ V D +G I +
Sbjct: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
Query: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVV 1019
A DAD RV YR + + F + +G ++ L+ E + L+V
Sbjct: 1125 KATDADEGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
Query: 1020 AFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS 1078
A++ M SS V + V E P FTQ++Y + E A GT V V+ A +
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 1079 ----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1134
+ Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPP 1291
Query: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1194
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYR 1349
Query: 1195 LIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1254
+ K F ++ TG+I L + ++ V+A DD G + V ++V
Sbjct: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITV 1408
Query: 1255 VNQLD 1259
+++ D
Sbjct: 1409 LDEND 1413
Score = 281 bits (718), Expect = 5e-75
Identities = 349/1345 (25%), Positives = 590/1345 (43%), Gaps = 164/1345 (12%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF-----DLVIKA 372
I ++ L+G F ++ T +++ V D + F +L++ A
Sbjct: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIID-REAFSPPILELLLLA 2043
Query: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
E D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++
Sbjct: 2044 E-DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVT 2092
Query: 433 ALDKDIEDVPPSGVPTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 491
A D+D SG+ + + D + VT G+ R +DREEQ++Y
Sbjct: 2093 ATDED------SGLNGELVYRIEAGAQDRFLIHLVT--GVIRVGNAT--IDREEQESYRL 2142
Query: 492 SITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
++ A D V S IV I + D ND+ P F V V PG + +TA+D D
Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
Query: 550 EGSNGEITYEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQA 597
N ++ Y I LV Q D F +N TG + + + + TY +T+
Sbjct: 2203 --LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSV 2260
Query: 598 ADNAPPA-ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQA 652
DNA ER S+ + + VL N+ +P P + Y +E I E G L+ + A
Sbjct: 2261 IDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAA 2320
Query: 653 TDRE---GDSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRP 707
D + +TY + + P L +++ G + + +D E + ASD G P
Sbjct: 2321 VDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 2380
Query: 708 DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS 767
+ V + + D+NDN P+FD + + + V ATD D+G + YS
Sbjct: 2381 PRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYS 2440
Query: 768 LGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVL 822
LG+ + F I + G IY L+RE +D+Y L +A D A + R +++ + I+VL
Sbjct: 2441 LGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVL 2500
Query: 823 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 880
D++D P F+ ++ V EN PAGT+++ + A D D G N ++Y + P V+ F +
Sbjct: 2501 DVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VD 2559
Query: 881 PFTGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPV 937
+G ++ R L YE F + V A D G PP G + V V D+ND PV
Sbjct: 2560 MDSGLVTTQRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPV 2610
Query: 938 FSKRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 995
F + + + + + + VYA D D GL + VRY F ++
Sbjct: 2611 FVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDP 2668
Query: 996 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE--- 1050
SG + T L+ E ++ L++VA D G+PV + + L P F +
Sbjct: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
Query: 1051 --EYRPPPVSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYV 1103
+Y+ V E + +GT+VG ++ A N + Y I +GNEE F + G + V
Sbjct: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLV 2787
Query: 1104 NGPLDYETRTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQ 1157
LD E + V+A S L + + +V + ++D N+ PP F
Sbjct: 2788 LRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFT 2847
Query: 1158 KKFYIGGVSEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVV 1209
K Y GV+ DA++ + +++V A D D GN YS++A +R + ++ + F +
Sbjct: 2848 KAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTM 2907
Query: 1210 ETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSN 1266
+ G+++T LF YF ++A D L+G D + + L D +V IV N
Sbjct: 2908 GSMDGILRTFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVIN 2962
Query: 1267 VPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAID 1326
P V E+ +L I GA +V + + H D ++ + +L ++ ++
Sbjct: 2963 EIPDRVRGFEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVN 3015
Query: 1327 PQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTE 1386
TNR +D + + + +D + F+ Y +L+++ +V + + + +
Sbjct: 3016 RDTNRILDVDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQ 3066
Query: 1387 GALLALAFIIILCCIPAILVVLVSY 1411
A++ LA ++ L A+L VL+++
Sbjct: 3067 MAIIVLAILLFLA---AMLFVLMNW 3088
Score = 273 bits (699), Expect = 8e-73
Identities = 320/1184 (27%), Positives = 520/1184 (43%), Gaps = 149/1184 (12%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
Query: 196 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
Query: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
L V +LD +D P+ P Y ++ E + ++
Sbjct: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
Query: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
Query: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
Query: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQ 487
I ALD D P+G T + + + F + + G+ +T + +D E
Sbjct: 1656 TIQALDLD---EGPNGTVT----YAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHG 1705
Query: 488 TYTFSITAFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
YT +TA D + + V+VN+ D NDN PTFP + T+ +PG V
Sbjct: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
Query: 541 IQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQA 597
A D D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A
Sbjct: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
Query: 598 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG 657
D P +S V I VL N+ P L ++ ISE V + + ++ A+D +
Sbjct: 1824 RDRGMPP--LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADS 1880
Query: 658 DS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 714
+T+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A
Sbjct: 1881 GCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIAR 1939
Query: 715 VN-----IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVH 765
+ I ++D NDN P+F + + A + G + A D D I V
Sbjct: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
Query: 766 YSL-GNFNNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAI 819
Y L G + LF I S+ + T V ++RE EL+++A D + +ST L I
Sbjct: 2000 YQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLI 2057
Query: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFF 877
+LD +DN P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F
Sbjct: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL 2117
Query: 878 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPP 936
+H TG ++R + +++ S V A D GT+P G A VT+++ D+ND P
Sbjct: 2118 -IHLVTG---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRP 2172
Query: 937 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPA 988
F I V A GT I + A D D ++ Y + DD P
Sbjct: 2173 EFLNPIQTVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQE 2228
Query: 989 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHP 1041
F V ++G V+ + +N E +++ + D+ V ++ TV +L ++
Sbjct: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
Query: 1042 GEIPRFTQE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095
P+F Y + E AT GT + ++A +N + Y+++ +
Sbjct: 2289 NT-PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
Query: 1096 NIT-GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1154
+ + G + N +DYE V + V ++ P ++ VY+EI D N++ P
Sbjct: 2348 DSSAGKVIANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
Query: 1155 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1214
+F + Y V ED + T +L V ATD D+GN++++ Y L +G+ F + TG
Sbjct: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTG 2455
Query: 1215 LIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1258
I ++ ++ +A D+ G S + + V VV Q+
Sbjct: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Score = 267 bits (683), Expect = 6e-71
Identities = 332/1252 (26%), Positives = 532/1252 (42%), Gaps = 159/1252 (12%)
Query: 106 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
Query: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
Query: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
Query: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
+Y+AAI E L IV +ID I Y T
Sbjct: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 403 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
S I E PVG ++ ++ P L +
Sbjct: 1421 TSDSAVSIPEDCPVGQRVAT----------------VKAWDPDAGSNGQVVFSLASGNIA 1464
Query: 462 SVFTVTQTGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNT 518
F + T + + + +P+DREE Y + A D + I+ + ++D NDN
Sbjct: 1465 GAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNP 1524
Query: 519 PTFPE-ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGL 576
P Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G
Sbjct: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
Query: 577 ITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
I P ++ Y L D P ++ VY+ ++ N+ +P F Q Y +
Sbjct: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEV 1641
Query: 636 EISEAM-RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
+ E + L+ +QA D + ++TYAI G+ F + G++T K LD E
Sbjct: 1642 LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE 1701
Query: 692 -STDRYILIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 746
S RY LI+TA+D P TST TV + V D+NDN P F V E +
Sbjct: 1702 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
Query: 747 FVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVV 801
V A D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L +
Sbjct: 1762 RVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
Query: 802 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 861
A D + P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G
Sbjct: 1822 CARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
Query: 862 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 919
N +++ I + + F ++ TG +++ R LD E P+ + +I+ + P
Sbjct: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------P 1935
Query: 920 GIA-----TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGL 970
IA + + + D ND P+F+K Y+ V ++ GTP+T + A DAD
Sbjct: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
Query: 971 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEP 1026
V Y++ Q + +F++ +G V R V ++ E + I +L+++A D G
Sbjct: 1996 AV--VTYQLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-- 2047
Query: 1027 VMSSSATVKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQS 1078
+++S+A + I +L + P F+ E PP S L T + +N
Sbjct: 2048 LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGE 2103
Query: 1079 IVYSIVSGNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137
+VY I +G +D F I+ +TGVI V N +D E + SY L V A V S
Sbjct: 2104 LVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLS 2155
Query: 1138 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1197
TA V I I D N+ P F V E A T + + A D D + Y ++
Sbjct: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVG 2213
Query: 1198 PPIKEG--------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249
K+ ++ F V TG + M +S +++AT + + A
Sbjct: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNAS 2265
Query: 1250 VL----VSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1297
L VSV N + V V +V + K +T ++R ++ PG ++
Sbjct: 2266 DLPERSVSVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Score = 220 bits (561), Expect = 8e-57
Identities = 254/924 (27%), Positives = 404/924 (43%), Gaps = 105/924 (11%)
Query: 395 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE 452
N+ P+FT + Y+L E PVG++++ +++A D D DP
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD-----------NDPL 65
Query: 453 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQ 510
+ + S F + T + L QP+DRE + +T FS++ GV + VNIQ
Sbjct: 66 VFGVSGEEASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQ 121
Query: 511 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570
V D NDN PTF Y V + + G + + A D D G+ G + Y +Q F I
Sbjct: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAI 180
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRF 628
+ G++T+ ++ + Y LTV A D P ++ + +V P F
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIF 236
Query: 629 PQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLG 685
L YS I E G + + A D++ I Y I +G+ +F L +G+LTL
Sbjct: 237 INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLN 296
Query: 686 KALDRES---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNL 737
LDRE+ + +IL + + D P D T T T NI+V D+NDNAP F+ ++
Sbjct: 297 GLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSV 355
Query: 738 SVVEEEANAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYT 785
++ E F QV D + G+N Y +GN ++ F I+ I
Sbjct: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
Query: 786 AVKLNREVRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844
A+ L+ E D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+
Sbjct: 416 AIPLDYETVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV 473
Query: 845 PAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902
GT++L + A D D G VSY + F+L TG + L+ LDYE
Sbjct: 474 TVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----Q 527
Query: 903 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 962
T + A D G G + V+ D+ND P F K Y G + + T + + A
Sbjct: 528 RFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 585
Query: 963 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVV 1018
D D P P +++ Y + V S F++ G + V+ L+ E + + L V
Sbjct: 586 TDEDSP--PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
Query: 1019 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
+A D G P ++S+ V I V + P F++ Y V + G V ++A +++
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDR 700
Query: 1078 SIVY---SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1133
S Y SI+ E T F IN +G I LD ET++ Y+L V+A V +
Sbjct: 701 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGH 755
Query: 1134 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1193
K+ A V I + D N++ P ++ Y + E + V V A D D G + Y
Sbjct: 756 NQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 1194 RLIIPPIKEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GL 1244
I PP K + + + TG I+T AML + V++ D G+
Sbjct: 816 S-IQPPNK----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
Query: 1245 SGKADVLVSVVNQLDMQVIVSNVP 1268
+ A V V++++ D N+P
Sbjct: 871 TSSATVFVNLLDLNDNDPTFQNLP 894
Score = 218 bits (555), Expect = 4e-56
Identities = 278/1062 (26%), Positives = 454/1062 (42%), Gaps = 142/1062 (13%)
Query: 96 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
Query: 149 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 208
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
Query: 209 FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
F+I TG + +R + + + I++ A+++ +T L + +LD +D P
Sbjct: 2010 FDIN-SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
Query: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
F P L + E P + A D+D + ++
Sbjct: 2068 TFSPATLT-----------------VHLLENCPPGFSVLQVTATDEDSGLNGE-----LV 2105
Query: 329 YSILVGTPEDYPRFFHMHPRTAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 387
Y I G + F +H T + + ++R+ + + L + A PL A +
Sbjct: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
Query: 388 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE---DVPPS 444
I I D N+ P F P +LESA G I++ I A+D D+ +
Sbjct: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
Query: 445 GVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--- 501
G+ KD L N + TG + + P++RE TY +++ D +
Sbjct: 2213 GIVAKDDTDRLVPNQEDAFAVNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
Query: 502 ---SEP-VIVNIQVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 554
S P + + V+D NDNTP F Y + PG ++I + AVD D+G NG
Sbjct: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
Query: 555 EITYEILVGAQGDFI--INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
+TY +L ++ + + G + V+ TV+A+DN P R +
Sbjct: 2330 LVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIP 2387
Query: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDP 669
VY+E++ N+ + P F Q Y + E + VG ++L + ATD + + I Y++ GD
Sbjct: 2388 VYLEIVDINDNN-PIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDG 2444
Query: 670 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVND 724
+ F ++ TTG + + +LDRE D YIL A D D S N I V DVND
Sbjct: 2445 ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVND 2504
Query: 725 NAPVFDPYLPR-NLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNG 781
P F P+ + SV E E A V + ATD D G NG++ YSL G F + +
Sbjct: 2505 CRPQFSK--PQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
Query: 782 SIYTAVKLNREVRDY--YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 838
+ T R ++ Y + L VVATDG P T L ++V+D++DN PVF T+
Sbjct: 2563 GLVTT---QRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
Query: 839 L-VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSL 892
L + E +P + + ++ A D D G N + R + FF + P +G + + L
Sbjct: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
Query: 893 DYEAFPDQEASITFLVEAFDI-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRI 942
D E+ +A + ++ A D+ Y TM P + V ++D++D P+F
Sbjct: 2680 DRES----QAVYSLILVASDLGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQ 2731
Query: 943 YKGMVAPD-AVKGTPITTVY-AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000
Y+ + P+ + +GT + V A DAD P + V Y + F ++ D +
Sbjct: 2732 YQLLTVPEHSPRGTLVGNVTGAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLL 2786
Query: 1001 ITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKI---LVLHPGEI---------PR 1046
+ R +L+ E IF +V A + P S T+ + L L + PR
Sbjct: 2787 VLR-DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPR 2845
Query: 1047 FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVS 1085
FT+ EY ++ ++ V++ A N + YSI++
Sbjct: 2846 FTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILA 2887
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 290 bits (743), Expect = 7e-78
Identities = 340/1253 (27%), Positives = 528/1253 (42%), Gaps = 130/1253 (10%)
Query: 47 TIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGR 106
T +A+ E GT V + GP+ + SL+ L + K TG
Sbjct: 1110 TFLAVAENQPPGTS-VGRVFATDRDSGPNGRLTYSLQQ------LSEDSKAFRIHPQTGE 1162
Query: 107 V-----LDRDPPMNIHSIVVQVQC----INKKVGTIIYHEVRIVVRDRNDNSPTFKHESY 157
V LDR+ + + ++VQVQ GT V + V D NDNSPTF S
Sbjct: 1163 VTTLQTLDREQQSS-YQLLVQVQDGGSPPRSTTGT-----VHVAVLDLNDNSPTFLQASG 1216
Query: 158 YA------TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI 211
A V + P GT + T A D D+G NG I Y + ++ F +
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTT-----LQAKDPDEGENGTILYTL-----TGPGSELFSL 1266
Query: 212 PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFL 271
+G ++ L ++ Y + + A+D+ + R+ + L V VL L
Sbjct: 1267 H-PHSGELLTAAPLIRAERPHYVLTLSAHDQG---SPPRSASLQLLVQVLPSARLAEP-- 1320
Query: 272 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 331
P+ + P + + E L P + + A + P+ + Y++
Sbjct: 1321 ----PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-------PAGVGALTYTL 1369
Query: 332 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 391
+ G D F + + L L P++ + + + + G + +++
Sbjct: 1370 VGGA--DPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQ 1427
Query: 392 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDP 451
DEN +P F + E+ GA + A D D P D
Sbjct: 1428 DENEHAPAFARDPLALALPENPEPGAAL---------YTFRASDAD------GPGPNSDV 1472
Query: 452 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-----GVQESEPVI 506
L L V + T L+ + +DRE + A D + + V
Sbjct: 1473 RYRL-LRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVS 1531
Query: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 566
+ V D NDN P F S V + D PG + + + A D D G ++Y + G G
Sbjct: 1532 ARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDG 1590
Query: 567 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
F ++ +TG +++ ++ + LTV A+D+ P + TV + + N P
Sbjct: 1591 HFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADV---NDEAP 1647
Query: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGK 686
F Q YS+ + E G LL L+ATD + + G F+L TG+LT +
Sbjct: 1648 TFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLR 1707
Query: 687 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 745
ALDRE + L + A D G P + TV + V D ND+AP F +L V E +
Sbjct: 1708 ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS-AHLSLEVPEGQDP 1766
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
+ ++A+DPD G NGQ+ Y + G+ + F + ++G T L+REV ++L +
Sbjct: 1767 QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIE 1826
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 862
A DG +TL L + VLD +D++P F Y+V V E++PAGT +LQ++A D D GA
Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA 1886
Query: 863 N--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-P 919
N V+Y + + F L P +GEL +LD E P S TF V A D P
Sbjct: 1887 NGHVTYYLGAGTAGAFL-LEPSSGELRTAAALDREQCP----SYTFSVSAVDGAAAGPLS 1941
Query: 920 GIATVTVIVKDMNDYPPVF-SKRIYKGMVAPDAVKGTP---ITTVYAEDADPPGLPASRV 975
+VT+ V+D+ND+ P F + + + P TP + T+ AED D G AS +
Sbjct: 1942 TTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRD-AGANAS-I 1999
Query: 976 RYRVDDVQFPYPASIFEVEEDSGRVI-TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 1034
YR+ P P + + RV + V L +F +VA D G P + SAT
Sbjct: 2000 LYRLAGT--PPPGTTVDSYTGEIRVARSPVALGPRDRVLF---IVATDLGRP--ARSATG 2052
Query: 1035 KILVLHPGEI---PRFTQEEYRPPPVSELATKGTMV---GVISAAAINQSIVYSIVSGNE 1088
I+V GE PRF + + E A GT + + A N I YSI+SGNE
Sbjct: 2053 VIIVGLQGEAERGPRFPRAS-SEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNE 2111
Query: 1089 EDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1146
+ TF I TG I V LD+E L +QA+S + + + +
Sbjct: 2112 KGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV----------LTLTL 2161
Query: 1147 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1206
QD N++ P F + Y+ + E + +L+V+A D D G+ ++Y L G
Sbjct: 2162 QDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL-- 2219
Query: 1207 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
F V+ TG I T + + + ++ATD L G A + V V++ D
Sbjct: 2220 FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
Score = 268 bits (685), Expect = 4e-71
Identities = 290/1144 (25%), Positives = 474/1144 (41%), Gaps = 142/1144 (12%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 196
V++ V+D N+++P F + + E G ++T + D GPN + Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP----GPNSDVRYRLL 1477
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ P P TG + + L+ E ++++A DR N + RR +
Sbjct: 1478 RQEPPVPALRLDAR-----TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSA 1532
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
V V D +D P+F A+ +R PE+ P + A D D
Sbjct: 1533 RVFVTDENDNAPVF------------------ASPSRVRLPEDQPPGPAALHVVARDPDL 1574
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ + Y + G F +H T LS++ P++R+ + L + A
Sbjct: 1575 -----GEAARVSYRLASGG----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
P A L + + D N+++P F Y + E+ P G TS L + A D
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG---------TSLLTLRATDP 1676
Query: 437 DI---EDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
D+ V GV ++ L TG+ LT L+ +DREEQ+ ++
Sbjct: 1677 DVGANGQVTYGGVSSESFSLD------------PDTGV---LTTLRALDREEQEEINLTV 1721
Query: 494 TAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551
A D + V V + V D ND+ PTF + V P ++ L A D D G
Sbjct: 1722 YAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVG 1780
Query: 552 SNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 610
+NG++ Y IL G G F+++ +G ++ V + L ++A D PA +
Sbjct: 1781 ANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLL 1840
Query: 611 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENG 667
TV VL N+ + P FP YS+E+ E + G +LL LQA D + + +TY + G
Sbjct: 1841 LTV--TVLDANDHA-PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG 1897
Query: 668 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDVNDN 725
F L ++G L ALDRE Y ++A DG G ++T +V I V DVND+
Sbjct: 1898 -TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDH 1956
Query: 726 APVFDPYLPRNLSVVE-----EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
AP F P P L + + ++A D DAG N + Y L +
Sbjct: 1957 APTF-PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDS 2015
Query: 781 --GSIYTA---VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 835
G I A V L R L +VATD R +T + + + + P F ++
Sbjct: 2016 YTGEIRVARSPVALGPRDR---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRAS 2072
Query: 836 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL--LRS 891
+ EN P GT I+ A G N ++Y I S K F++ P TG +++
Sbjct: 2073 SEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEG 2131
Query: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 951
LD+E P + E+ + +T+ ++D ND P F + Y +
Sbjct: 2132 LDFEVSP--RLRLVLQAESGGAF-----AFTVLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
Query: 952 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEP 1010
P+ V A+D D ++ Y + Q PA +F V+ +G + T L+ E
Sbjct: 2185 PLEGPLLQVEADDLDQGS--GGQISYSLAASQ---PARGLFHVDPTTGTITTTAILDREI 2239
Query: 1011 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVI 1070
+LV++A D G P + SAT+ ++V+ + R T + VSE A G+ + +
Sbjct: 2240 WAETRLVLMATDRGSPALVGSATLTVMVIDTND-NRPTIPQPWELRVSEDALLGSEIAQV 2298
Query: 1071 SAAAINQSIV--YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1128
+ ++ V Y + +D F + G + + GPLD+E Y L++ A
Sbjct: 2299 TGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----- 2353
Query: 1129 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1188
A + + ++D N++ P F + Y + E +++L V ATD+D+G
Sbjct: 2354 -----GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGAN 2408
Query: 1189 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1248
++Y L P +GF V+ G + F ++ T G SG
Sbjct: 2409 GHISYHLASP-----ADGFSVDPNNGTL---------------FTIVGTVALGHDGSGAV 2448
Query: 1249 DVLV 1252
DV++
Sbjct: 2449 DVVL 2452
Score = 256 bits (653), Expect = 2e-67
Identities = 316/1208 (26%), Positives = 500/1208 (41%), Gaps = 152/1208 (12%)
Query: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
+T R LDR+ I+ V + + VR+ V D ND++PTF V
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761
Query: 163 E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 221
E P T+ A+D D G NGQ++Y I D + F + L +G
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL----DGDPSGAFVLDLA-SGEFGT 1809
Query: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF-LPCVLVPNTR 280
+ L+ E + + + I+A D Q + T LTV VLD +D P F +P V
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ---PALSATLLLTVTVLDANDHAPAFPVPAYSV---- 1862
Query: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
PE++ + +QA D D + Y + GT
Sbjct: 1863 --------------EVPEDVPAGTLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA-- 1901
Query: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPY 399
F + P + EL ++R+ + + A + PL + I + D N+ +P
Sbjct: 1902 --FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959
Query: 400 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDVPPSGVPTK 449
F + + P +T + +L + LR A D+D + PP G
Sbjct: 1960 FPTSPLRLRLPRPGPSFSTPTLAL---ATLR--AEDRDAGANASILYRLAGTPPPGTT-- 2012
Query: 450 DPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNI 509
++ YT V ++ + L P DR T S ++ +
Sbjct: 2013 -------VDSYTGEIRVARSPVA-----LGPRDR----VLFIVATDLGRPARSATGVIIV 2056
Query: 510 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDF 568
+ + P FP S + + + PG ++ AV A G+NG ITY IL G + G F
Sbjct: 2057 GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTF 2115
Query: 569 IINKTTGLITI--APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
I +TG IT+ A G++ V L +QA A TV L N + P
Sbjct: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFA------FTVLTLTLQDANDNAP 2169
Query: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQR-VFNLSETTGIL 682
RF + Y + E+ + LL ++A D + G I+Y++ P R +F++ TTG +
Sbjct: 2170 RFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229
Query: 683 TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVE 741
T LDRE L++ A+D G P +AT+ ++V D NDN P P L V E
Sbjct: 2230 TTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ--PWELRVSE 2287
Query: 742 EEA-NAFVGQVKATDPDAG---------INGQVHYSLGNFNNLFRITSNGSIYTAVKLNR 791
+ + + QV D D+G Q +S+G + +T L+
Sbjct: 2288 DALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG--------PLDF 2339
Query: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
E D Y+L ++A DG P L + V D++DN+P F+ S Y V++ E+ P G+ IL
Sbjct: 2340 EQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL 2396
Query: 852 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 909
+ A D D GAN +SY + SP F++ P G L + D ++ ++E
Sbjct: 2397 SVSATDRDSGANGHISYHLASPA--DGFSVDPNNGTLFTIVGT-VALGHDGSGAVDVVLE 2453
Query: 910 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 969
A D ATV V ++D ND+ P F+ Y+ V D G+ + T+ A DAD
Sbjct: 2454 ARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSR 2513
Query: 970 LPASRVRYRVDDVQ----FPYPASIFEVEEDSGR-------VITRVNLNEEPTTIFKLVV 1018
A+ V Y + F + E E +G ++ L+ E T + L V
Sbjct: 2514 SHAA-VDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTV 2572
Query: 1019 VAFDDGEPVMSSSATVKILVLHPGEIPR-FTQEEYRPPPVSELATKGTMVGVISAAAI-- 1075
A D G+P SS V + VL + P FT+ YR + ++ V ++ A
Sbjct: 2573 AAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG 2632
Query: 1076 -NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1134
+ + +++ SG+ F ++ +G + + LD ET+ + L VQA P
Sbjct: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----------P 2682
Query: 1135 SKSN--TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1192
+ ++ A V IE+QD N+H P F V+E+ T V + A D D G + +
Sbjct: 2683 AGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLR 2742
Query: 1193 YRLI-IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1251
Y L+ P EG+E F + + TG ++ + F F+ V A D S VL
Sbjct: 2743 YSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVL 2802
Query: 1252 VSVVNQLD 1259
V+ ++ D
Sbjct: 2803 VTGEDEYD 2810
Score = 252 bits (643), Expect = 3e-66
Identities = 314/1248 (25%), Positives = 505/1248 (40%), Gaps = 131/1248 (10%)
Query: 51 IDEESRNGTILVDNM--LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVL 108
IDEE GT++ D L GTA I V + +D ++ T RVL
Sbjct: 51 IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV---RTARVL 107
Query: 109 DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 168
DR+ V G + EV + V D ND++P F V E T G
Sbjct: 108 DREQRDRYRFTAVTPD------GATV--EVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
Query: 169 TTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPTSNDTFEIPLMLTGNIVL 221
T A D D G G Y + + + D +P +V+
Sbjct: 160 TRYPL-----EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP-----ELVV 209
Query: 222 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
L+ E+++ Y + ++A D + R L V +LD +D P F
Sbjct: 210 TGELDRENRSHYMLQLEAYDGG---SPPRRAQALLDVTLLDINDHAPAF----------- 255
Query: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE-DYP 340
Y A + E P +P++ + A D D + + Y I E D P
Sbjct: 256 -NQSRYHAVVSESLAPG--SPVL---QVFASDADAGVNG-----AVTYEINRRQSEGDGP 304
Query: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 400
F + T L L P++ + + +LV++A HP A + + + D N+ P
Sbjct: 305 --FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM 362
Query: 401 TMPSYQG----YILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLF 456
T+ + E+AP G ++ RI D D D V + E H
Sbjct: 363 TVIFLSADGSPQVSEAAPPGQLVA---------RISVSDPDDGDFAHVNVSLEGGEGHFA 413
Query: 457 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMD 513
L+ TQ + + + + +DREE+ Y +TA D +E V + V D
Sbjct: 414 LS--------TQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTD 464
Query: 514 ANDNTPTFPEISYDVYVYTDMR-PGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIIN 571
NDN P F Y ++ PG V+++TA D D+G+NG++TY + GA F I+
Sbjct: 465 VNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSID 524
Query: 572 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 631
T+G+IT A ++ + L V A D P ++ +V ++ + N + P+F +
Sbjct: 525 PTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV---NDNEPQFQRT 581
Query: 632 MYSLEISEAMRVGAVLLNLQATDREGDS---ITYAI-----ENGDPQRVFNLSETTGILT 683
Y+ + E + G L + ATD + ++Y++ +G P F + +G +
Sbjct: 582 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVC 639
Query: 684 LGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
+ LDR+ + +TA DG S V + ++D NDN P F P +
Sbjct: 640 TTRTLDRDQGPSSFDFTVTAVDGG-GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQS 698
Query: 743 EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYT-AVKLNREVRDYYEL 799
V +++A DPD G +G++ Y + GN LF + + T A L R +L
Sbjct: 699 PPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQL 758
Query: 800 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
+ A DG + + I ++ P+F Y V E++ GT++ ++A +
Sbjct: 759 EIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP 818
Query: 860 LG-ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF-PDQEASITFLVEAFDIYGTM 917
A V+ + + + F+L +G L LR LD E P E + +
Sbjct: 819 GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVR-------AGSGV 871
Query: 918 PPG--IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 975
PP +A V V++ D+ND P F ++ P+ GTPI T+ A D D S V
Sbjct: 872 PPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD------SGV 925
Query: 976 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1035
RV F V+ +G V L +L + A D G P +S ++
Sbjct: 926 NSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLR 985
Query: 1036 ILVLHPGE---IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS-IVYSIVSGNEEDT 1091
++V G PRF YR S T GT V + A A + I Y + +
Sbjct: 986 VVVQDVGTRGLAPRFNSPTYRVDLPSG-TTAGTQVLQVQAQAPDGGPITYHLAAEGASSP 1044
Query: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
FG+ +G ++V LD E + Y+L+V A V + + ++ TA V + I ++N
Sbjct: 1045 FGLEPQSGWLWVRAALDREAQELYILKVMA----VSGSKAELGQQTGTATVRVSILNQNE 1100
Query: 1152 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
H P + V+E+ TSV RV ATD+D+G + Y L + E + F +
Sbjct: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL--QQLSEDSKAFRIHP 1158
Query: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
TG + T ++S ++ V D S V V+V++ D
Sbjct: 1159 QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLND 1206
Score = 252 bits (643), Expect = 3e-66
Identities = 299/1098 (27%), Positives = 460/1098 (41%), Gaps = 130/1098 (11%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
+ V D ND++P F +Y V E P GT + A D D G NG + Y +
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL-----QLQAHDPDAGANGHVTYYLGAG 1897
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
T+ P +G + L+ E Y + A D A +TT ++T+
Sbjct: 1898 ----TAGAFLLEPS--SGELRTAAALDREQCPSYTFSVSAVDGAAA--GPLSTTVSVTIT 1949
Query: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
V D +D P F PL + P P P + ++A D+D
Sbjct: 1950 VRDVNDHAPTF----------PTSPLRLRLPRPG---PSFSTPTLALATLRAEDRDAGAN 1996
Query: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGH 378
ILY L GTP P + T E+ + PV + ++ D G
Sbjct: 1997 A-----SILYR-LAGTP---PPGTTVDSYTGEIRVARSPVALGPRDRVLFIVAT--DLGR 2045
Query: 379 PLPAFAGLHIEILD-ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
P + G+ I L E + P F S + I E+AP G I SP + A
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI------VSPRAVHAGG-- 2097
Query: 438 IEDVPPSGVPTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
T P + L+ + F++ + + + +D E + A
Sbjct: 2098 ----------TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147
Query: 497 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 556
G + V+ + + DANDN P F Y ++ ++Q+ A D D+GS G+I
Sbjct: 2148 SGGAFAFTVLT-LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQI 2206
Query: 557 TYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 614
+Y + A+G F ++ TTG IT ++ + L + A D PA ++ TV
Sbjct: 2207 SYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVM 2266
Query: 615 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVF 673
+ N + P PQ + L +SE +G+ + + D + G + Y + PQ F
Sbjct: 2267 VI---DTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPF 2322
Query: 674 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 733
++ G ++L LD E DRY L + A DG +G + TV +V DVNDNAP F L
Sbjct: 2323 SVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV--LVEDVNDNAPAFSQSL 2380
Query: 734 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT---AVKL 789
+ + + + + V ATD D+G NG + Y L + + F + +NG+++T V L
Sbjct: 2381 YQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVAL 2440
Query: 790 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 849
+ ++V+ A D R + T+ +++ D +D++P FT S Y V V E+LP G+T
Sbjct: 2441 GHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGST 2500
Query: 850 ILQIEAKDVDLG---ANVSYRIRSPEVKHFFALHPFTGE--------------LSLLRSL 892
+L +EA D D A V Y I S F L P E L LL L
Sbjct: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
Query: 893 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 952
D+E+ ++ A D + VTV V D+ND PPVF++ Y+ V D
Sbjct: 2561 DFESLTQYNLTVA----AADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTP 2616
Query: 953 KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT 1012
G + V A DADP P VR+ V P+ +FE++E SG + L+ E
Sbjct: 2617 VGAELLHVEASDADPG--PHGLVRFTVSSGD---PSGLFELDESSGTLRLAHALDCETQA 2671
Query: 1013 IFKLVVVAFDD-GEPVMSSSATVKILVLH------PGEIPRFTQEEYRPPPVSELATKGT 1065
+LVV A D G + T+++ ++ P + + E +PP GT
Sbjct: 2672 RHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP--------GT 2723
Query: 1066 MVGVISA----AAINQSIVYSIVSGNE----EDTFGINNITGVIYVNGPLDYETRTSYVL 1117
+V + A A + YS++ + F +N+ TG + P DYE S+ L
Sbjct: 2724 LVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRL 2783
Query: 1118 RVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR 1177
V A NL S S T V + +DE + PVF + V E AR S+
Sbjct: 2784 LVGAADA----GNL---SASVTVSVLVTGEDE--YDPVFLAPAFHFQVPEGARRGHSLGH 2834
Query: 1178 VKATDKDTGNYSVMAYRL 1195
V+ATD+D G ++ Y L
Sbjct: 2835 VQATDEDGGADGLVLYSL 2852
Score = 234 bits (598), Expect = 4e-61
Identities = 259/1051 (24%), Positives = 438/1051 (41%), Gaps = 129/1051 (12%)
Query: 116 IHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 173
+H +VVQ + + ++G+ V + VRD NDN P+ T IF
Sbjct: 327 VHELVVQARDGGAHPELGSAF---VTVHVRDANDNQPSM----------------TVIF- 366
Query: 174 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN--------------- 218
S D + P GQ+ V + + DP D + + L G
Sbjct: 367 -LSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
Query: 219 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 278
+ + +RL+ E++ Y + + A D + + V D +D P F
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSG---SPPLRAEAAFVLHVTDVNDNAPAF-------- 472
Query: 279 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 338
R L +PE+ P +V + DQ N Q + YS+ G
Sbjct: 473 ---DRQLYRPEPLPEVALP---GSFVVRVTARDPDQGTNGQ-------VTYSLAPGA--- 516
Query: 339 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 398
+ +F + P + ++ ++ + + L++ A PL + A + + + D N+ P
Sbjct: 517 HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEP 576
Query: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLN 458
F Y + E G T L++ A D D P G+ + L +
Sbjct: 577 QFQRTFYNASLPEGTQPG---------TCFLQVTATDADSG---PFGLLSYSLGAGLGSS 624
Query: 459 DYTSVFTVTQTGITRYLTLLQPVDREE-QQTYTFSITAFDGVQESEPVIVNIQVMDANDN 517
+G + + +DR++ ++ F++TA DG V V + + D NDN
Sbjct: 625 GSPPFRIDAHSGD---VCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDN 681
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGL 576
P F Y + PG +V++L A D D+GS+G ++Y IL G F +++ +GL
Sbjct: 682 PPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGL 741
Query: 577 ITIAPGVEMIVGRTYALTVQAAD----NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 632
+T+A + L + A D A P+ R V I ++ P +PP F QL
Sbjct: 742 LTVAWPLARRANSVVQLEIGAEDGGGLQAEPSAR------VDISIV-PGTPTPPIFEQLQ 794
Query: 633 YSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDR 690
Y + E + G + +QA + G +T ++ GDP+ +F+L +G+L + LDR
Sbjct: 795 YVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854
Query: 691 ESTDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 749
E + L + A G P + A V +++ DVNDN+P F L +
Sbjct: 855 ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY 914
Query: 750 QVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 807
++A DPD+G+N +V ++L G + G + L +EL + A DG
Sbjct: 915 TLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG 974
Query: 808 VHPRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS 865
PR S L + V D+ +P F + TY V + AGT +LQ++A+ D G ++
Sbjct: 975 SPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPIT 1033
Query: 866 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGT-----MPPG 920
Y + + F L P +G L + +L D+EA ++++ + G+ G
Sbjct: 1034 YHLAAEGASSPFGLEPQSGWLWVRAAL------DREAQELYILKVMAVSGSKAELGQQTG 1087
Query: 921 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 980
ATV V + + N++ P S+ VA + GT + V+A D D P R+ Y +
Sbjct: 1088 TATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQ 1145
Query: 981 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH 1040
Q + F + +G V T L+ E + ++L+V D G P S++ TV + VL
Sbjct: 1146 --QLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLD 1203
Query: 1041 PGE-IPRFTQEEYR-----PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1090
+ P F Q P V + GT+V + A N +I+Y++ +G +
Sbjct: 1204 LNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSE 1262
Query: 1091 TFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
F ++ +G + PL R YVL + A
Sbjct: 1263 LFSLHPHSGELLTAAPLIRAERPHYVLTLSA 1293
Score = 226 bits (577), Expect = 1e-58
Identities = 292/1111 (26%), Positives = 467/1111 (42%), Gaps = 150/1111 (13%)
Query: 45 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104
PA V + E+ GT+L+ AG +V Y++ L S+
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGA---------NGHVTYYLGAGTAGAFLLEPSS 1908
Query: 105 GRV-----LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 158
G + LDR+ P S+ + T + V I VRD ND++PTF
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLR 1966
Query: 159 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 218
+ P +T + A D D G N I Y + P T+ D++ TG
Sbjct: 1967 LRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLAGTPPPGTTVDSY------TGE 2019
Query: 219 I-VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD-DLGPMFLPCVLV 276
I V R + + R I+ A +L + T + + L G+ + GP F
Sbjct: 2020 IRVARSPVALGPRDRVLFIV-----ATDLGRPARSATGVIIVGLQGEAERGPRF------ 2068
Query: 277 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 336
P +A I E PP I R + I YSIL G
Sbjct: 2069 PRASS------EATIREN-----------APPGTPIVSPRAVHAGGTNGPITYSILSGNE 2111
Query: 337 EDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 394
+ F + P T +++ DF + LV++AE AF L + + D N
Sbjct: 2112 KGT---FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDAN 2165
Query: 395 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA--LDKDIEDVPPSGVPTKDPE 452
+ +P F P Y ++ ES P+ + L++ A LD+ + P
Sbjct: 2166 DNAPRFLRPHYVAFLPESRPLEGPL---------LQVEADDLDQGSGGQISYSLAASQPA 2216
Query: 453 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVN---- 508
LF D T+ T+T T I +DRE + A D P +V
Sbjct: 2217 RGLFHVDPTTG-TITTTAI---------LDREIWAETRLVLMATD---RGSPALVGSATL 2263
Query: 509 -IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV--GAQ 565
+ V+D NDN PT P+ +++ V D G + Q+T D D +G + + +L G Q
Sbjct: 2264 TVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQ 2319
Query: 566 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 625
F + + G +++ ++ Y L + A D P E R ++ TV +E + N +
Sbjct: 2320 DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANL-TVLVEDV---NDNA 2373
Query: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL 682
P F Q +Y + + E G+ +L++ ATDR+ + I+Y + + P F++ G L
Sbjct: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS--PADGFSVDPNNGTL 2431
Query: 683 --TLGK-ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS 738
+G AL + + +++ A D G P + ATV++ + D ND+AP F R
Sbjct: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAV 2491
Query: 739 VVEEEANAFVGQVKATDPDAG-INGQVHYSL--GNFNNLFRITSN--------------- 780
+ + + ++ATD D + V YS+ GN+ +F++
Sbjct: 2492 TEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRAL 2551
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
G + L+ E Y L V A D P+ S + + + VLD++DN PVFT ++Y V V
Sbjct: 2552 GCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTV 2611
Query: 841 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 898
E+ P G +L +EA D D G + V + + S + F L +G L L +LD E
Sbjct: 2612 PEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET-- 2669
Query: 899 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 958
+A +V+A D G +A VT+ V+D+ND+ P F + VA + GT +T
Sbjct: 2670 --QARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVT 2726
Query: 959 TVYAEDADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1017
T++A D D R+RY + + P F + +G + RV + E T F+L+
Sbjct: 2727 TLHAIDGDAGAF--GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLL 2784
Query: 1018 VVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA--- 1073
V A D G +S+S TV +LV E P F + V E A +G +G + A
Sbjct: 2785 VGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-VPEGARRGHSLGHVQATDED 2841
Query: 1074 -AINQSIVYSIVSGNEEDTFGINNITGVIYV 1103
+ ++YS+ + + FGIN TG +Y+
Sbjct: 2842 GGADGLVLYSLATSSPY--FGINQTTGALYL 2870
Score = 81.3 bits (199), Expect = 8e-15
Identities = 112/466 (24%), Positives = 184/466 (39%), Gaps = 76/466 (16%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 194
V + ++D+ND++P+F Y V E P G+T+ T ATD D + ++Y
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522
Query: 195 -------VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 247
V Q P + ++ G +VL + L++E T+Y + + A DR Q
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ--- 2579
Query: 248 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
+++ +TV VLD +D P+F TR +Y+ +PE TP + V
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVF--------TR----ASYRVTVPE-DTPVGAELLHV-- 2624
Query: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
+A D D P + +++ G P F + + L L ++ + +
Sbjct: 2625 --EASDAD-----PGPHGLVRFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQ 2674
Query: 368 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA------TISD 421
LV++A G A A + IE+ D N+ P F + + E+ P G I
Sbjct: 2675 LVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDG 2733
Query: 422 SLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPV 481
LR L+ P + LN T L P
Sbjct: 2734 DAGAFGRLRYSLLEAG---------PGPEGREAFALNSSTGE-----------LRARVPF 2773
Query: 482 DREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
D E +++ + A D S V V++ V ++ P F ++ V R G S+
Sbjct: 2774 DYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLG 2833
Query: 542 QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI-----APG 582
+ A D D G++G + Y L + F IN+TTG + + APG
Sbjct: 2834 HVQATDEDGGADGLVLYS-LATSSPYFGINQTTGALYLRVDSRAPG 2878
Score = 52.0 bits (123), Expect = 5e-06
Identities = 68/290 (23%), Positives = 106/290 (36%), Gaps = 45/290 (15%)
Query: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFD--------------DGEPVMSSSATVKILV 1038
++E SG V T L+ E ++ V D D P + +
Sbjct: 94 IDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVP 153
Query: 1039 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1098
H R+ E R L T+G Y++ +TF +
Sbjct: 154 EHTAFGTRYPLEPARDADAGRLGTQG----------------YALSGDGAGETFRLETRP 197
Query: 1099 GV-------IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
G + V G LD E R+ Y+L+++A + P + A + + + D N+
Sbjct: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEA-------YDGGSPPRRAQALLDVTLLDIND 250
Query: 1152 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
H P F + Y VSE + VL+V A+D D G + Y I EG F ++
Sbjct: 251 HAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE-INRRQSEGDGPFSIDA 309
Query: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1261
+TGL++ +R + V A D G A V V V + D Q
Sbjct: 310 HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQ 359
Score = 32.7 bits (73), Expect = 3.2
Identities = 32/121 (26%), Positives = 50/121 (41%), Gaps = 16/121 (13%)
Query: 1387 GALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAA 1446
GA+ A ++++ + A+++ LV R R+AE QAA P A ++
Sbjct: 2939 GAVAASLGVVVVLALAALVLGLVRARS---RKAEAAPGPMSQAA-PLASDSLQKLGR--- 2991
Query: 1447 PPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEE 1506
PP PPP HLY + ++ Y P G P G + G E E++
Sbjct: 2992 --EPPSPPPSEHLYHQ----TLPSYGGPGAGGP---YPRGGSLDPSHSSGRGSAEAAEDD 3042
Query: 1507 E 1507
E
Sbjct: 3043 E 3043
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 290 bits (741), Expect = 1e-77
Identities = 278/992 (28%), Positives = 456/992 (45%), Gaps = 99/992 (9%)
Query: 143 RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201
R RN N+ P F+ SY ATV E P GT + A D D+G G++EY +
Sbjct: 171 RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
Query: 202 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261
D SN F + +TG + + L+ E K+ + + A D RR+ TLT+ V
Sbjct: 225 DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
Query: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
D +D P+F Q LR E+ ++T ++A D D PP
Sbjct: 281 DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
Query: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
+ ILY +L G+ F + PR+ + PV+R+ + + L ++A P P
Sbjct: 321 N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
Query: 382 --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
A + + + D+N+ +P F+ Y + E GA + LR+ A D+D
Sbjct: 379 RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRD-- 427
Query: 440 DVPPSGVPTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
+ +H + N + QTG L ++ P+D E + YT + A
Sbjct: 428 -------KGSNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQ 477
Query: 497 DGVQ---ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
DG + + +V +QV+D NDN P F + V + G V+ + A+DAD G N
Sbjct: 478 DGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDN 537
Query: 554 GEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
+ Y + VG F IN TG I++A ++ Y+ V+A D+ PA ++ +
Sbjct: 538 ARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVS 597
Query: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQR 671
V + + NN P F Q Y++ ++E VG ++ + A DR+ S ITY I +G+ +
Sbjct: 598 VTVLDVNDNN---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN 654
Query: 672 VFNLSETT--GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 729
F+++ + G+++L LD + +Y+L +TASDG T+ VN VTD N + PVF
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVF 712
Query: 730 -DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAV 787
+ N++ + A V + ATD D G N ++ Y + + FRI ++ G++ T
Sbjct: 713 QSSHYTVNVN-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQA 771
Query: 788 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 847
+L+ E + Y L + A D + + T L I V D++DN+P F +Y V E++P
Sbjct: 772 ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPF 831
Query: 848 TTILQIEAKDVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 904
T++LQI A D D G N V Y + + F + +G + LR L D+E
Sbjct: 832 TSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVA 885
Query: 905 TFLVEAFDIYGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 962
+++ A+ + MPP VTV V D+ND PPVF + + V ++ G + V A
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
Query: 963 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1022
D D +++ Y++ + P +F+++ SG + V+L+ E + LV+ A
Sbjct: 946 TDPDEG--TNAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA-- 998
Query: 1023 DGEPVMSSSATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAIN 1076
P++ S ATV + +L +P + F + G +G + A I+
Sbjct: 999 TSAPLV-SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDIS 1057
Query: 1077 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1108
S+ YS GNE +N TG + ++ LD
Sbjct: 1058 DSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 288 bits (737), Expect = 3e-77
Identities = 254/895 (28%), Positives = 420/895 (46%), Gaps = 68/895 (7%)
Query: 395 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELH 454
N +P F PSYQ + E+ P G ++ + A+D D E T D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPD-EGEAGRLEYTMDALFD 225
Query: 455 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVM 512
N + S+ VT +T + +DRE + T+ F +TA D + S + I V
Sbjct: 226 SRSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVT 280
Query: 513 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----F 568
D ND+ P F + Y + ++ G V+ + A D D N I Y +L G+ G F
Sbjct: 281 DTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340
Query: 569 IINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRF 628
I+ +G+I V+ +Y LTV+A+D R++ V++ V +N + P+F
Sbjct: 341 EIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQF 399
Query: 629 PQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLG 685
+ Y +++ E + GA +L + A+DR+ S + Y+I +G+ + F L TG L +
Sbjct: 400 SEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVV 459
Query: 686 KALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 743
LD E+T Y L + A DG P + V + V D+NDNAP+F P +V+E
Sbjct: 460 SPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESV 518
Query: 744 ANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYEL 799
+ V V+A D DAG N ++ Y L + F T N G I A +L+RE D+Y
Sbjct: 519 PLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSF 578
Query: 800 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
V A D ++ ++++ VLD++DN+P FT YTV + E+ GT+++ + A D D
Sbjct: 579 GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
Query: 860 LGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 917
+ ++Y+I S ++ F++ +G +SL LDY+ E V A D GT
Sbjct: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR 692
Query: 918 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 977
A + V V D N + PVF Y V D GT + + A D D +R+ Y
Sbjct: 693 -QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITY 749
Query: 978 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 1037
++D P F ++ D+G V T+ L+ E + L + A D+G P S + ++IL
Sbjct: 750 FMED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL 804
Query: 1038 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-T 1091
V + P+F ++ Y+ V E T V ISA + +N + Y+ G++ D
Sbjct: 805 VNDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD 863
Query: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
F + + +G++ LD E YVLR A + +P +V + + D N+
Sbjct: 864 FIVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVND 916
Query: 1152 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
+PPVF++ + V E++ + +V RV ATD D G + + Y+++ I E F ++
Sbjct: 917 NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDI 973
Query: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
++G + + R + + AT L +A V V ++++ D ++ N
Sbjct: 974 FSGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
Score = 281 bits (719), Expect = 4e-75
Identities = 267/902 (29%), Positives = 403/902 (44%), Gaps = 90/902 (9%)
Query: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 341
+P +YQA +PE N TP + R I P G L Y++ +
Sbjct: 182 QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230
Query: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 400
FF + P T ++ E ++R+ + A QD+G P A A L I + D N+ P F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 401 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFL--- 457
Y+ + E+ VG + L + A D D P L+ L
Sbjct: 290 EQQEYKESLRENLEVGYEV---------LTVRATDGD--------APPNANILYRLLEGS 332
Query: 458 -NDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQV 511
+ VF + ++G+ R PVDREE ++Y ++ A D ++ P V + V
Sbjct: 333 GGSPSEVFEIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV 389
Query: 512 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFII 570
D NDN P F E Y V V D+ PG V+++TA D D+GSN + Y I+ G A+G F +
Sbjct: 390 EDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYL 449
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFP 629
+ TG + + ++ + Y L V+A D PP + + TV + + N + P F
Sbjct: 450 DAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFV 506
Query: 630 QLMYSLEISEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGK 686
+ + E++ +G ++L++QA D + GD+ + Y + F ++ TG +++
Sbjct: 507 STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA 566
Query: 687 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA- 744
LDRE D Y + A D G P T++A+V++ V DVNDN P F P + E+A
Sbjct: 567 ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAA 624
Query: 745 -NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELV 800
V V A D DA + GN N F ITS G + A+ L+ ++ Y L
Sbjct: 625 VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
Query: 801 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 860
V A+DG R T + + V D + + PVF +S YTV V E+ PAGTT++ I A D D
Sbjct: 685 VTASDGT---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT 741
Query: 861 GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 920
G N + F + TG ++ LDYE + S T + A D
Sbjct: 742 GENARITYFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSD 797
Query: 921 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV- 979
+ ++V D+ND P F + Y+G V D T + + A D D GL RV Y
Sbjct: 798 TTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQ 855
Query: 980 --DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 1037
DD F VE SG V T L+ E + L A D G P + V +
Sbjct: 856 GGDDGD-----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVT 910
Query: 1038 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1093
VL + P +++ V E + G V ++A N I+Y IV GN + F
Sbjct: 911 VLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQ 970
Query: 1094 INNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1153
++ +G + LDYE R YVL +QA S +V + A V++ + D N++P
Sbjct: 971 LDIFSGELTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNP 1020
Query: 1154 PV 1155
PV
Sbjct: 1021 PV 1022
Score = 281 bits (718), Expect = 5e-75
Identities = 262/925 (28%), Positives = 420/925 (45%), Gaps = 116/925 (12%)
Query: 44 PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 100
PP+ + E GT + I +G AG + T++ + + +DPV +
Sbjct: 183 PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
Query: 101 LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 159
+T LDR+ ++ + Q + ++ + I+V D ND+ P F+ + Y
Sbjct: 242 --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
Query: 160 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 218
++ E VG + T ATD D PN I Y +++ + P ++ FEI +G
Sbjct: 297 SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
Query: 219 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 278
I R ++ E+ Y + ++A+D+ ++ R+TT + + V D +D P F V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
Query: 279 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 338
R E++ P + A D+D+ + YSI+ G
Sbjct: 408 VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
Query: 339 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 397
F++ +T L ++ P++ + +++ L ++A+ PL +GL +++LD N+ +
Sbjct: 446 Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
Query: 398 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFL 457
P F +Q +LES P+G + L + A+D D D + L L
Sbjct: 503 PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGD---------NARLEYRL 544
Query: 458 NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVM 512
F T T ++++ +DREE Y+F + A D P + V++ V+
Sbjct: 545 AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVL 601
Query: 513 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIIN 571
D NDN PTF + Y V + D G SV+ ++AVD D ++ ITY+I G + F I
Sbjct: 602 DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSIT 659
Query: 572 KTT--GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 629
+ GL+++A ++ + R Y L V A+D R + + V N P F
Sbjct: 660 SQSGGGLVSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQ 713
Query: 630 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 686
Y++ ++E G ++ + ATD E ITY +E+ PQ F + TG +T
Sbjct: 714 SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQA 771
Query: 687 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEE 743
LD E Y L ITA D G P + T + I+V DVNDNAP F D Y V E+
Sbjct: 772 ELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYED 827
Query: 744 ANAF--VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDY 796
F V Q+ ATD D+G+NG+V Y+ G+ + + TS G + T +L+RE
Sbjct: 828 VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQ 886
Query: 797 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 856
Y L A D + P + + + + VLD++DN PVF + V VEEN P G + ++ A
Sbjct: 887 YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTAT 946
Query: 857 DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 914
D D G N + Y+I + F L F+GEL+ L LDYE P+ I
Sbjct: 947 DPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQ 997
Query: 915 GTMPPGIATVTVIVK--DMNDYPPV 937
T P ++ TV V+ D ND PPV
Sbjct: 998 ATSAPLVSRATVHVRLLDRNDNPPV 1022
Score = 230 bits (587), Expect = 8e-60
Identities = 217/774 (28%), Positives = 344/774 (44%), Gaps = 87/774 (11%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDN+P F + Y V E G + A+D D G N + Y I
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
+ F + TG + + L+YE Y + ++A D + + +T
Sbjct: 440 SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
V VLD +D P+F+ + PL Y + +QAID D
Sbjct: 493 VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
D + Y L G D+P F ++ T +S+ ++R+ + ++A +D+G
Sbjct: 536 -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
Query: 378 HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
P L A A + + +LD N+ +P FT P Y + E A VG TS + + A+D+
Sbjct: 587 TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
Query: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
D V + + + + F++T ++L P+D + ++ Y ++TA
Sbjct: 638 DAHSVITYQITS---------GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
Query: 497 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 556
DG ++ IV + V DAN + P F Y V V D G +V+ ++A D D G N I
Sbjct: 689 DGTRQDTAQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARI 747
Query: 557 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 616
TY + + F I+ TG +T ++ +Y L + A DN P + T Y+E
Sbjct: 748 TY-FMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLE 802
Query: 617 VLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QR 671
+L + N + P+F + Y + E + +L + ATDR+ + Y + GD
Sbjct: 803 ILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDG 862
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD 730
F + T+GI+ + LDRE+ +Y+L A D G P + V + V DVNDN PVF+
Sbjct: 863 DFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE 922
Query: 731 PYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIY 784
V EE + V +V ATDPD G N Q+ Y + GN +F++ +G +
Sbjct: 923 ---QDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
Query: 785 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVL 839
V L+ E R Y LV+ AT P S T+ +++LD +DN PV N + Y
Sbjct: 980 ALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTN 1036
Query: 840 VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 893
+ P G I ++ A D D+ +++Y L+ TGEL L R+LD
Sbjct: 1037 RSSSFPGG-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 140 bits (353), Expect = 1e-32
Identities = 160/595 (26%), Positives = 253/595 (42%), Gaps = 79/595 (13%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDN+PTF Y +NE VGT++ T + D A VI
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
Query: 198 YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Y + + F I G +V L L+Y+ + +Y + + A+D R T +
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
V+V D + P+F N + RP + I A D+D
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ I Y + P+ F + T ++ ++ + + L I A +DN
Sbjct: 742 G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
Query: 377 GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
G P + L I + D N+ +P F SYQG + E P TS L+I A D
Sbjct: 791 GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSIT 494
+D SG+ + +D F V T GI R L L DRE Y
Sbjct: 842 RD------SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAY 892
Query: 495 AFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 552
A D G+ + P+ V + V+D NDN P F + +DV+V + G +V ++TA D DEG+
Sbjct: 893 AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
Query: 553 NGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 611
N +I Y+I+ G + F ++ +G +T ++ Y L +QA +AP R
Sbjct: 953 NAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----A 1007
Query: 612 TVYIEVLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENG 667
TV++ +L N+ P F L + + + G + + A D + DS+TY+ E G
Sbjct: 1008 TVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERG 1067
Query: 668 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 721
+ + L+ +TG L L +ALD I+ + SDG T+ + + ++TD
Sbjct: 1068 NELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
Score = 83.2 bits (204), Expect = 2e-15
Identities = 108/460 (23%), Positives = 191/460 (41%), Gaps = 79/460 (17%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
++ + V D N + P F+ Y VNE P GTT+ ATD D G N +I Y +
Sbjct: 697 QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ S F I TG + + L+YED+ Y + I A D N +++ TT L
Sbjct: 752 E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
+ V D +D P FL RD +YQ ++ E++ P I A D+D
Sbjct: 802 EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ + Y+ G +D F + + + L ++R+ ++ L A
Sbjct: 845 GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
P + + +LD N+ P F + ++ E++P+G ++ R+ A D
Sbjct: 898 MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
Query: 437 D-------IEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTY 489
D + + +P + +L +F + LT L +D E++ Y
Sbjct: 949 DEGTNAQIMYQIVEGNIP-EVFQLDIFSGE---------------LTALVDLDYEDRPEY 992
Query: 490 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTA 545
I A S V+++++D NDN P EI ++ YV + PG ++ ++ A
Sbjct: 993 VLVIQATSAPLVSR-ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPA 1051
Query: 546 VDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 584
D D + +TY G + + +N +TG + ++ ++
Sbjct: 1052 HDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 277 bits (708), Expect = 8e-74
Identities = 256/937 (27%), Positives = 426/937 (45%), Gaps = 96/937 (10%)
Query: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 345
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 346 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 404
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPS--------GVPTKDPELHLF 456
Y+ + E+ G I L++ A D D PP+ G P
Sbjct: 438 YRETLRENVEEGYPI---------LQLRATDGD---APPNANLRYRFVGPPAARAAA--- 482
Query: 457 LNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQV 511
+ F + ++G+ ++ VDRE ++Y + A D QE P V V+I V
Sbjct: 483 ----AAAFEIDPRSGL---ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITV 535
Query: 512 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFII 570
+D NDN P F E Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I
Sbjct: 536 LDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI 595
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFP 629
+ TG I + ++ R YAL ++A D PP + ++ + + N P F
Sbjct: 596 DSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFV 652
Query: 630 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 686
+ + + E +G ++++QA D E + Y++ P F ++ TG +++
Sbjct: 653 STPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG 712
Query: 687 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN 745
LDRES + Y + A D G P +++A+V + V DVNDN P F + + E+A
Sbjct: 713 PLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAA 770
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSI---YTAVKLNREVRDYYELV 800
V T D N + Y + GN N F I++ G + A+ L+ + Y++LV
Sbjct: 771 VGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLV 830
Query: 801 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 860
+ A+D A+H + I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+
Sbjct: 831 LTASDRALHDH---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDV 887
Query: 861 GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 920
G N + F + +G ++L LDYE + + T + A D
Sbjct: 888 GENARITYLLEDNLPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKAD 943
Query: 921 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 980
V V+V D+ND P F Y G+V+ DA T + + A D D RV+Y
Sbjct: 944 TTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQ 1001
Query: 981 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH 1040
+ + F +E SG V T L+ E ++++L A D G P + + +++++V
Sbjct: 1002 NGEDG--DGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQD 1059
Query: 1041 PGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095
+ P F EE+ V E + G++V I+A N I+Y IV GN + F ++
Sbjct: 1060 VNDNAPVFPAEEFEVR-VKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMD 1118
Query: 1096 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
+G + LDYE R YV+ VQA S +V + A V++ + D+N++ PV
Sbjct: 1119 IFSGELTALIDLDYEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPV 1168
Query: 1156 FQ--KKFYIGGVSEDARMFTS--VLRVKATDKDTGNY 1188
+ + VS + F S + R+ A D D ++
Sbjct: 1169 LNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH 1205
Score = 270 bits (691), Expect = 7e-72
Identities = 245/824 (29%), Positives = 379/824 (45%), Gaps = 94/824 (11%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
Query: 198 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
Query: 317 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
Query: 376 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
Query: 435 DKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
D D + + L L T ++++ P+DRE + Y F +
Sbjct: 677 DADHGE---------NARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
Query: 495 AFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 552
A D S V + V+D NDN P F Y + + D G SV+ +TAVD D +
Sbjct: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
Query: 553 NGEITYEILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
N I+Y+I G + F I+ GL+T+A ++ R + L + A+D A +
Sbjct: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHD 840
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN 666
C V+I + N P F YS+ ++E +G+ ++ + A+D E ITY +E+
Sbjct: 841 HCYVHINITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
PQ F + +G +TL LD E Y L ITA D G P T V ++V DVNDN
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDN 957
Query: 726 APVFDPYLPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-S 779
AP F +V E+A F Q+ ATD DA NG+V Y+ N + F I +
Sbjct: 958 APQF--VASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1015
Query: 780 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 839
+G + T +L+RE YEL A D V P + +++ + V D++DN+PVF + V
Sbjct: 1016 SGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR 1075
Query: 840 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 897
V+EN G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA
Sbjct: 1076 VKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA- 1134
Query: 898 PDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 939
QE I + T P ++ TV V+ D ND PV +
Sbjct: 1135 -RQEYVIV-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
Score = 246 bits (628), Expect = 1e-64
Identities = 247/905 (27%), Positives = 410/905 (45%), Gaps = 86/905 (9%)
Query: 395 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED----VPPSGVPTKD 450
N+ P F +YQ + E+ G T+ LR+VA D D + V
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
Query: 451 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVN 508
L LF D Q+G+ R L DRE + + +TA D + S +V
Sbjct: 371 RSLELFSID-------PQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVA 420
Query: 509 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------V 562
+ V D ND++P F + Y + ++ G ++QL A D D N + Y +
Sbjct: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA 480
Query: 563 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 622
A F I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+
Sbjct: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
Query: 623 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 679
+ P+F + Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + T
Sbjct: 541 NA-PQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLT 599
Query: 680 GILTLGKALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNL 737
G + + LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +
Sbjct: 600 GEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQV 658
Query: 738 SVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLN 790
SV+E NA +G ++A D D G N ++ YSL + F I S G + + L+
Sbjct: 659 SVLE---NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLD 715
Query: 791 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 850
RE ++Y V A D P ++ ++ + VLD++DN P FT Y + + E+ GT++
Sbjct: 716 RESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSV 775
Query: 851 LQIEAKDVDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLV 908
+ + A D D + +SY+I ++ FA+ G ++L LDY+ QE ++
Sbjct: 776 VSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVL 831
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 968
A D V + + D N + PVF Y V D G+ I + A D D
Sbjct: 832 TASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG 888
Query: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
+R+ Y ++D P F ++ DSG + + L+ E + L + A D+G P
Sbjct: 889 --ENARITYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK 941
Query: 1029 SSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSI 1083
+ + V+++V + P+F Y VSE A T V ISA A N + Y+
Sbjct: 942 ADTTYVEVMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF 1000
Query: 1084 VSGNEED-TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1142
+G + D F I +G++ LD E + Y L A + VP +
Sbjct: 1001 QNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSI 1053
Query: 1143 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1202
+ +QD N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I
Sbjct: 1054 QVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI-- 1111
Query: 1203 GKEGFVVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1261
E F ++ ++G + + L + R+ Y VI L +A V V +V+Q D
Sbjct: 1112 -PELFQMDIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNS 1166
Query: 1262 VIVSN 1266
+++N
Sbjct: 1167 PVLNN 1171
Score = 245 bits (625), Expect = 3e-64
Identities = 258/984 (26%), Positives = 435/984 (44%), Gaps = 96/984 (9%)
Query: 150 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 209
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
Query: 210 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 269
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
Query: 270 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 329
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
Query: 330 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 384
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
Query: 385 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPS 444
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D + +
Sbjct: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKD---AN 577
Query: 445 GVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---E 501
G+ +H + S +T + ++ P+D E ++ Y I A D +
Sbjct: 578 GL------VHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLS 631
Query: 502 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 561
+ + +IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y +
Sbjct: 632 NNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 562 -VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLP 619
V F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V
Sbjct: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV-- 749
Query: 620 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET 678
N + P F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S
Sbjct: 750 --NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQ 807
Query: 679 --TGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 736
G++TL LD + + L++TASD +NI TD N + PVF +
Sbjct: 808 GGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYS 864
Query: 737 LSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVR 794
+SV E+ + + + A+D D G N ++ Y L + FRI ++ G+I L+ E +
Sbjct: 865 VSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQ 924
Query: 795 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 854
Y L + A D + + T + + V D++DN+P F S YT LV E+ P T++LQI
Sbjct: 925 VTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQIS 984
Query: 855 AKDVDLGAN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 911
A D D AN V Y ++ E F + P +G + +R LD EA E + A+
Sbjct: 985 ATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AY 1038
Query: 912 DIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 969
+ +PP ++ V+V+D+ND PVF ++ V +++ G+ + + A D D
Sbjct: 1039 AVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG- 1097
Query: 970 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1029
P + + Y++ + P +F+++ SG + ++L+ E + +VV A P++S
Sbjct: 1098 -PNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVS 1151
Query: 1030 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIV 1084
+ LV P + + G+I ++ + YS
Sbjct: 1152 RATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFE 1211
Query: 1085 SGNEEDTFGINNITGVIYVNGPLD 1108
GNE +N +G + ++ LD
Sbjct: 1212 RGNELQLLVVNQTSGELRLSRKLD 1235
Score = 233 bits (595), Expect = 1e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 514 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 569
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 570 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 629
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
Query: 630 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 681
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 682 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 738
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
Query: 739 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 793
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 794 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 852
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 853 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 910
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
Query: 911 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 969
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
Query: 970 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1029
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
Query: 1030 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1085
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 1086 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1145
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
Query: 1146 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1205
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
Query: 1206 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
G F +E +G+++T S ++ A D
Sbjct: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
Score = 132 bits (331), Expect = 4e-30
Identities = 151/595 (25%), Positives = 258/595 (43%), Gaps = 84/595 (14%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
Query: 198 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
Query: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
Query: 435 DKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTF 491
D+D + F N D FT+ T GI R + L DRE Y
Sbjct: 987 DRDAH--------ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYEL 1035
Query: 492 SITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
+ A D GV PV + + V D NDN P FP ++V V + G V Q+TAVD D
Sbjct: 1036 TAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPD 1095
Query: 550 EGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 608
EG N I Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R
Sbjct: 1096 EGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR-- 1152
Query: 609 SICTVYIEVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAI 664
TV++ ++ N+ SP Q++++ +S ++ + A D + D + Y+
Sbjct: 1153 --ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSF 1210
Query: 665 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
E G+ ++ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 1211 ERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 271 bits (693), Expect = 4e-72
Identities = 285/1082 (26%), Positives = 476/1082 (43%), Gaps = 119/1082 (10%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 197
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
+ +LD +D P F+ + P E++ + I A D
Sbjct: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
Query: 318 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
Query: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
Query: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITA 495
D SGV +K + + +F + + TG T+L DRE Q+ +T +
Sbjct: 1297 D------SGVNSK-LQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLV 1346
Query: 496 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
DG S + V D ND+ P F SYD+ V + P + V + A D D G+N
Sbjct: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNN 1405
Query: 554 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
+ Y I+ G + F IN+ +G ++ ++ + L + +D P R+S+
Sbjct: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIH 1463
Query: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQ 670
+ + VL N+ S P FP L Y + E VG V+L L A D++ + T +
Sbjct: 1464 LQVRVLDANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS 1522
Query: 671 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV 728
F + +G L LDRE+ ++ A D G+ + TV + VTDVNDN PV
Sbjct: 1523 GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPV 1582
Query: 729 -----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGS 782
FD +L E N V+A D D G NG V +S ++F I G
Sbjct: 1583 LEQNPFDVFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE 1637
Query: 783 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 842
I + E + + V G P +T L + ++ +D F++ Y LV E
Sbjct: 1638 IQFQQNPSSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTE 1695
Query: 843 NLPAGTTILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPD 899
N AGT+I+ ++A D + ++ Y I S +L +G+L++ + LD+E
Sbjct: 1696 NCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--R 1753
Query: 900 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 959
E + L E+ + V V+++D ND P F + IY+ V+ + +
Sbjct: 1754 NEVQLIVLAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
Query: 960 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1019
V+A D D GL + Y + F+++ SG + T+ L+ E T+ + L+V
Sbjct: 1809 VFATDLD-SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQ 1863
Query: 1020 AFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAIN 1076
A D G P +S++ +K+ V + P F E ++E + G +V +S +N
Sbjct: 1864 ATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLN 1921
Query: 1077 QSIVYSIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVP 1134
+ ++S + T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1922 SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-------- 1973
Query: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1194
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR
Sbjct: 1974 ---TEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYR 2028
Query: 1195 LI 1196
++
Sbjct: 2029 IL 2030
Score = 271 bits (693), Expect = 4e-72
Identities = 306/1155 (26%), Positives = 494/1155 (42%), Gaps = 137/1155 (11%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
Query: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
Query: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
Query: 380 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 439
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
Query: 440 DVPPSGVPTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD- 497
G+ + + FL D S FT+ T L +DRE + +TFS A D
Sbjct: 1507 ----EGL---NGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDC 1557
Query: 498 GVQ--ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 555
+Q S VI+ + V D NDN P + +DV++ + + + + A D D G NG
Sbjct: 1558 SIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGT 1617
Query: 556 ITYEILVGAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTV 613
+ + Q F I+K TG I P E L ++ D PA + +
Sbjct: 1618 VVFSF-AETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVI 1673
Query: 614 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQR 671
++E F +Y ++E G ++ ++A D DS+ Y+I +G+
Sbjct: 1674 HME----GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
Query: 672 VFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 729
V +L +G LT+ K LD E + LI+ A + V +++ D NDN+P F
Sbjct: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCF 1787
Query: 730 DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTA 786
+ + + + NA V QV ATD D+G+NG + YS+ GN F+I + +G I T
Sbjct: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Query: 787 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 846
L+ E+ Y L+V ATD + +T + ++V DI+DN+P F S + E++LP
Sbjct: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
Query: 847 GTTILQIEAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 903
G + + DVDL + + +P K FA+ TG + L+++LD+E + E
Sbjct: 1907 GVIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELL 1964
Query: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
I G + V V D+ND PPVFS+ Y+ V G + T+ A
Sbjct: 1965 IQISDSVHYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT 2017
Query: 964 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVA 1020
D + + YR+ + F ++ +G + T + L+ TT F +V A
Sbjct: 2018 DLESN----ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEA 2066
Query: 1021 FDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AA 1074
D G P + + V+I + P FT + Y +SE A G+ + S
Sbjct: 2067 SDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTR 2125
Query: 1075 INQSIVYSIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSL 1124
N + YSI+SGN ++ F + G + + LD E S+ L
Sbjct: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------EL 2178
Query: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
++ ++ P S+TA + I++ D N++PP F Y V E + + + V A D+D
Sbjct: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD 2238
Query: 1185 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1244
TG+++ + Y +I K F +E TG++ + + F V A+D K
Sbjct: 2239 TGSHAEIIYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF 2295
Query: 1245 SGKADVLVSVVNQLD 1259
S A V VSV++ D
Sbjct: 2296 S-FAVVFVSVLDDND 2309
Score = 259 bits (661), Expect = 2e-68
Identities = 281/1157 (24%), Positives = 495/1157 (42%), Gaps = 137/1157 (11%)
Query: 142 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
Query: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
Query: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 377
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
Query: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
+ + + D N+ P + ++ +P T V + D
Sbjct: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT------------VIVRAD 1608
Query: 438 IEDVPPSGVPT---KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 494
D+ P+G + + ++ YT Q + Y + + +Q
Sbjct: 1609 DLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-------- 1660
Query: 495 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
G+ + + M+ D +F Y V + G S++ + A A +
Sbjct: 1661 ---GIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQD 1716
Query: 555 EITYEILVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSIC 611
+ Y I G + G + +G +T+ ++ V L V A + + C
Sbjct: 1717 SMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYC 1771
Query: 612 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGD 668
V + + N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+
Sbjct: 1772 KVAVLIQDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGN 1830
Query: 669 PQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP 727
+ F + +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP
Sbjct: 1831 QEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAP 1890
Query: 728 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIY 784
F LP + E++ V + D +N +S +N F I N +
Sbjct: 1891 AF---LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVV 1947
Query: 785 TAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 843
VK L+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E+
Sbjct: 1948 VLVKTLDFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPES 2004
Query: 844 LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 903
+P G ++L + A D++ N+SYRI S + F++ P G + + + D ++
Sbjct: 2005 IPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTIST 2059
Query: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
FLVEA D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T
Sbjct: 2060 TQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNI 2119
Query: 964 DADPPGLPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKL 1016
D D + V Y + F F E + G ++ +L+ E + +L
Sbjct: 2120 DHDWTR-ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHEL 2178
Query: 1017 VVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA--- 1072
V++A D G P +SS+A + I VL + P F+ Y V E G+ + V+SA
Sbjct: 2179 VILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDR 2237
Query: 1073 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1131
+ I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 2238 DTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE------ 2291
Query: 1132 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1191
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y +
Sbjct: 2292 --KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
Query: 1192 AYRLIIP-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1246
Y ++ P + + F+++ TG I + + + V A D
Sbjct: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD-------- 2401
Query: 1247 KADVLVSVVNQLDMQVI 1263
K D S+V +D++ I
Sbjct: 2402 KGDATASLVVWVDIEGI 2418
Score = 243 bits (621), Expect = 9e-64
Identities = 294/1167 (25%), Positives = 477/1167 (40%), Gaps = 140/1167 (11%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+ D L L G++ E+R T TL
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
+ + + V++ T++ + ++ E L+P+ T +Q Q
Sbjct: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM--TQMLQT--QAH 610
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE-QD 375
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
Query: 376 NGHPLPAFAGLHIEILDENNQSPYFT----------MPSYQGYILESAPVGATISDSLNL 425
+G + + + DEN+ SP F P QG I + A DS
Sbjct: 668 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKN 724
Query: 426 TSPLRIVALDKDIEDVPPSGVPT----------------------KDPELHLFLNDYTSV 463
L + D + P+ P EL F+ S+
Sbjct: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV--LKSL 782
Query: 464 FTVTQTG-ITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPT 520
F G + ++ L DRE + + ++ D + + V + V D NDN P
Sbjct: 783 FCELGEGELINWVAL----DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838
Query: 521 FPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKTTG 575
FP+ ++ + G V L A D DEG+N E+TY + D F I+ G
Sbjct: 839 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG 898
Query: 576 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
I + +Y ++V A D P + ++ V I+V+P + + Q + L
Sbjct: 899 EIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVIPLS-KGRAIMSQNIRHL 955
Query: 636 EISEAMRVGAVLLNLQATDR----EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
I E ++ ++ ++++D + ++I D F + +TG L L K LD E
Sbjct: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
Query: 692 STDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 749
+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N +G
Sbjct: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVPIG 1071
Query: 750 QV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYELV 800
+ A D D +N ++ Y + + N N F I S G++ T +L+RE L
Sbjct: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
Query: 801 VVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 857
V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A D
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHD 1190
Query: 858 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 915
D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 1191 PDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDDGT 1246
Query: 916 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 975
T+TV V D+ND PVF + +Y+ V + G +T V A D D S V
Sbjct: 1247 PALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------SGV 1300
Query: 976 RYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 1034
++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+ T+
Sbjct: 1301 NSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
Query: 1035 KILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1091
V + P F Y + E T++ A N+++ Y I+ GN ++
Sbjct: 1361 LCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
Query: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D N+
Sbjct: 1421 FTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDAND 1473
Query: 1152 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1211
H P F +Y V EDA + T VL + A DKD G Y L E F ++
Sbjct: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTIDP 1529
Query: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATD 1238
+G +KT+ RS F +A D
Sbjct: 1530 MSGTLKTSNTLDREARSQHTFSAVARD 1556
Score = 224 bits (572), Expect = 4e-58
Identities = 266/1110 (23%), Positives = 478/1110 (43%), Gaps = 115/1110 (10%)
Query: 108 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 166
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
Query: 167 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 226
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
Query: 227 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
Query: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Query: 347 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 405
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
Query: 406 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFT 465
+LE+ + ++A D D + + E H+ + FT
Sbjct: 1380 DIEVLENQEPEVVYT----------VLASDMDAGN-------NRAVEYHIIDGNTDECFT 1422
Query: 466 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPE 523
+ + ++ L+ + +DRE+ +T I D S + + ++V+DAND++P+FP
Sbjct: 1423 INE--MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 524 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 583
+ Y V D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + +
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
Query: 584 EMIVGRTYALTVQAADNAPPAERRNS-ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 642
+ + + A D + R + I VY+ + N + P Q + + +S
Sbjct: 1541 DREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV---NDNDPVLEQNPFDVFLSPESP 1597
Query: 643 VGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 701
+ ++A D + G + T + Q +F++ + TG + + E ++ +
Sbjct: 1598 TNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKV 1657
Query: 702 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 761
G P T+T + ++ + D F +L + L EA + VKA PD+ I
Sbjct: 1658 TDQGIPARTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQ 1715
Query: 762 GQVHYSL--GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLT 816
+ YS+ GN + + + S T + L+ EVR+ +L+V+A +
Sbjct: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCK 1772
Query: 817 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 874
+A+ + D +DNSP F S Y V E+ ++Q+ A D+D G N + Y I S +
Sbjct: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
Query: 875 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 934
F + +G ++ LDYE +S + +V+A D + V V D+ND
Sbjct: 1833 EAFQIDALSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDN 1888
Query: 935 PPVF--SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 992
P F S+ + + D++ G +T V D D + + P + F
Sbjct: 1889 APAFLPSEAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFA 1939
Query: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1052
+++++G V+ L+ E T ++L++ D V + + + VL + P +++
Sbjct: 1940 IDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDF 1996
Query: 1053 RPPPVSELATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---L 1107
V E G V +SA + N++I Y I+S ++E F I+ G I+ P L
Sbjct: 1997 YQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLL 2054
Query: 1108 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1167
D + T +++ P V I I+D NN+ P F K Y +SE
Sbjct: 2055 DTISTTQFLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
Query: 1168 DARMFTSVLRVKATDKD-TGNYSVMAYRLI 1196
DA + ++++ D D T + + Y +I
Sbjct: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
Score = 212 bits (539), Expect = 3e-54
Identities = 296/1126 (26%), Positives = 480/1126 (42%), Gaps = 125/1126 (11%)
Query: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
Query: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
Query: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
Query: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
+PE +P T I D D ++ P +++S +
Sbjct: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
Query: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDVPPSGVPTKDPELHLFLNDYT 461
Y+G + E+ G TS + + A D I+D + + + + L L +
Sbjct: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKS 1737
Query: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTF 521
TV + + R E Q + ++ G + V V IQ D NDN+P F
Sbjct: 1738 GQLTVKEPKFLDFEV------RNEVQLIVLAESS--GHRAYCKVAVLIQ--DENDNSPCF 1787
Query: 522 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 580
+ Y V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT
Sbjct: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Query: 581 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 640
++ + +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E
Sbjct: 1848 AILDYELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITED 1903
Query: 641 MRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 697
G ++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y
Sbjct: 1904 SLPGVIVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYE 1962
Query: 698 LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 757
L+I SD V ++ DVNDN PVF + V + ATD +
Sbjct: 1963 LLIQISDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
Query: 758 AGINGQVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTL 815
+ N + Y + + + F I NG+I+T + L + + +V A+DG +P L
Sbjct: 2021 S--NENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRAL 2077
Query: 816 TLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP 871
TL I + D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 2078 TLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG 2137
Query: 872 --------EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 921
E K F + +P+ G L LL SLD EA AS ++ A D
Sbjct: 2138 NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSST 2193
Query: 922 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 981
A +++ V D+ND PP FS Y V G+ IT V A D D G A + +
Sbjct: 2194 AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISG 2252
Query: 982 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1041
+ + F +EE++G + L+ E T F L V A D E S A V + VL
Sbjct: 2253 NEKGH----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDD 2307
Query: 1042 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEE 1089
+ P+F + L T+ + + A + YSIVS +
Sbjct: 2308 NDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDH 2367
Query: 1090 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1149
D F I+ +TG I+ LDYE Y L VQA A+L V+++I+
Sbjct: 2368 DLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGI 2418
Query: 1150 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
+ P+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 2419 DEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
Score = 210 bits (534), Expect = 1e-53
Identities = 296/1153 (25%), Positives = 482/1153 (41%), Gaps = 137/1153 (11%)
Query: 50 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 109
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
Query: 110 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 168
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 169 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 227
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
Query: 228 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 286
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
Query: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 346
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Query: 347 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 404
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
Query: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVF 464
YQ + ES A + +++ A D D SG+ E + + F
Sbjct: 1792 YQASVSESQLYNAHV---------IQVFATDLD------SGLNGLI-EYSILSGNQEEAF 1835
Query: 465 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFP 522
+ ++ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F
Sbjct: 1836 QID--ALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL 1893
Query: 523 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 582
S V + D PG V ++ D D S ++ F I++ TG++ +
Sbjct: 1894 P-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKT 1952
Query: 583 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 642
++ Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++
Sbjct: 1953 LDFEEMTEYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIP 2006
Query: 643 VGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILII 700
VG +L L ATD E ++I+Y I + + F++ G I T+ L ++ ++
Sbjct: 2007 VGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLV 2064
Query: 701 TASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----D 755
ASDG PD + V I + D+N+ AP F NLS+ E+ A VG T D
Sbjct: 2065 EASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNID 2120
Query: 756 PD-AGINGQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVV 801
D N V YS+ GN N F + + G + L+RE +ELV+
Sbjct: 2121 HDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVI 2180
Query: 802 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 861
+A+D P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G
Sbjct: 2181 LASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTG 2240
Query: 862 --ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 919
A + Y I S K F L TG L L++ LDYE + T V+A D
Sbjct: 2241 SHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHF 2295
Query: 920 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 979
A V V V D ND+ P F + +V + + I ++ A D D P + Y +
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSI 2353
Query: 980 DDVQF-----PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 1034
F Y +F ++ +G + + L+ E + L V A D G+ S V
Sbjct: 2354 VSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWV 2413
Query: 1035 KILVLHPGEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1091
I + E P FTQ++Y P + G + + A I+ I+YS+ G
Sbjct: 2414 DIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPF 2470
Query: 1092 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1151
F +N G IY+ L S + + ++++ + + SK + V++ + +
Sbjct: 2471 FSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSE 2528
Query: 1152 HPP--VFQKKFYI 1162
P VF F I
Sbjct: 2529 GTPLAVFASSFSI 2541
Score = 204 bits (519), Expect = 6e-52
Identities = 303/1262 (24%), Positives = 517/1262 (40%), Gaps = 186/1262 (14%)
Query: 35 EDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 89
++ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
Query: 90 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
Query: 149 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
Query: 206 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 261
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
Query: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 316
D +D P FL VL L+ E P V I AID D
Sbjct: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
Query: 317 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 352
+ P + G +Y I GT D + F + EL
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 353 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 405
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 406 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIED--VPPSGVPTKDPELHLFLNDYT 461
+ + +LE PV ++ + A D D + V ++D H ++
Sbjct: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKID--- 894
Query: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTP 519
G R T+L + + +Y S+ A D GV + +VNIQV+ +
Sbjct: 895 -----ANNGEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRA 946
Query: 520 TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLI 577
+ + + +++P + + + D + NG++ + I+ G F I+ +TG +
Sbjct: 947 IMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDL 1006
Query: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLE 636
++ ++ Y V D+ ++ + TV++ + + N P F + +
Sbjct: 1007 FLSKELDYETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVIS 1063
Query: 637 ISEAMRVGAVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRE 691
+ E + +G ++ A D +G I Y IE+ +P F + + G L LDRE
Sbjct: 1064 VEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRE 1123
Query: 692 STDRYILIITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANA 746
S IL +TASD + T + T IV+ DVND+ P F + N V E+ +
Sbjct: 1124 SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGS 1181
Query: 747 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 803
V + A DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A
Sbjct: 1182 LVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
Query: 804 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 863
D S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N
Sbjct: 1242 LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVN 1301
Query: 864 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 921
+ + I F ++ TGE+ L D+E F + G P
Sbjct: 1302 SKLQFEIMPGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLS 1355
Query: 922 ATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 979
+T T++ V+D ND+ P F Y V + + + TV A D D A V Y +
Sbjct: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHI 1412
Query: 980 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1039
D F + E SG + T L+ E + F LV++ D G+P SS +++ VL
Sbjct: 1413 IDGN---TDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL 1469
Query: 1040 HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095
+ Y V E A GT+V V+SA +N Y ++ F I+
Sbjct: 1470 DANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTID 1528
Query: 1096 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
++G + + LD E R+ + A + S+S T + + + D N++ PV
Sbjct: 1529 PMSGTLKTSNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPV 1582
Query: 1156 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1215
++ + +S ++ + + V+A D D G + + E + F ++ YTG
Sbjct: 1583 LEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGE 1637
Query: 1216 IK 1217
I+
Sbjct: 1638 IQ 1639
Score = 184 bits (468), Expect = 5e-46
Identities = 258/1099 (23%), Positives = 449/1099 (40%), Gaps = 133/1099 (12%)
Query: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
P + ++I ++D N+ P F S + I ++ P G + + L +
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
Query: 439 EDVPPSGVPTKDPELH-LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 497
P GV D L LFLN + EQ+ T ++ A D
Sbjct: 519 IASPQPGVFAIDRALGVLFLNG--------------------SLGAGEQRELTLTLRAED 558
Query: 498 -GVQESEPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSN 553
GV ++V V++ +++P TF + Y V V + P ++Q A + +
Sbjct: 559 QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 618
Query: 554 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
+ Y + F I TG I + + +TY V A +N T
Sbjct: 619 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTT 677
Query: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGD 668
V + V N+ SP +++ L++ E+ V+ + A D + G + + + +G
Sbjct: 678 VIVRVWDENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG- 735
Query: 669 PQRVFNLSETTG------ILT-------------------------------LGK----- 686
+ F ++ TG ++T LG+
Sbjct: 736 --KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELIN 793
Query: 687 --ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVV 740
ALDRE + + + +D G P +T V + VTD+NDN P F LP ++ V+
Sbjct: 794 WVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVL 853
Query: 741 E-EEANAFVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDY 796
E + N V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R
Sbjct: 854 EGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS 913
Query: 797 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 856
Y + V+ATD V P + I+V+ + + + + +++ ENL + I++
Sbjct: 914 YRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSS 973
Query: 857 D---VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 913
D + + I + + F + TG+L L + LDYE + F V D
Sbjct: 974 DHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDH 1029
Query: 914 YGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 972
+ +++ V+D ND+ P F + V + GT + A+D D L
Sbjct: 1030 SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-N 1088
Query: 973 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS--- 1029
SR++Y ++ + F + G ++T L+ E L V A D V
Sbjct: 1089 SRIQYYIE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL 1146
Query: 1030 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1084
S T +I++L + P F + V E T G++V I+A N + YSI+
Sbjct: 1147 RSLTAQIVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL 1204
Query: 1085 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1144
SGNE TF ++ +G++ PLDYE +T ++L V A + P+ S++ + +
Sbjct: 1205 SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTV 1257
Query: 1145 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1204
+ D N+ PVF++ Y V E+ V RV+A D+D+G S + + I+P
Sbjct: 1258 TVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASF 1314
Query: 1205 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIV 1264
E F + + TG + T + + F +V+ D LS +L +V ++ D
Sbjct: 1315 ELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND----- 1369
Query: 1265 SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYA 1324
+ P +V D+ E+L+ E + G R + ++ T T+
Sbjct: 1370 -HAPEFIVSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
Query: 1325 IDPQ--TNRAIDRNELFKF 1341
+ + T RA+DR ++ F
Sbjct: 1426 MSGELSTTRALDREQISNF 1444
Score = 122 bits (305), Expect = 4e-27
Identities = 248/1114 (22%), Positives = 421/1114 (37%), Gaps = 150/1114 (13%)
Query: 340 PRFFHMHPRTAELSLLEPVNRDFHQK-FDLVIKA----EQDNGH------PLPAFAGLHI 388
P+ F + P ++ + + ++R+ +DL+++A EQ H L A A + +
Sbjct: 106 PQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRV 165
Query: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
++ D N+ P F +Y I + G I + ++A D+D SG+
Sbjct: 166 DLEDVNDNHPVFNPSTYVTSISDETQPGTEI---------INVLATDQD------SGI-Y 209
Query: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT--AFDGVQESEPVI 506
L + +S+FT+ T T L + E FS + ++ P++
Sbjct: 210 GTVAYELIPGNVSSLFTIDST------TGLYSPEVEILSAVNFSADKEVMNSLEMFLPLL 263
Query: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 566
+ + ++ D + + + + L D ++GE A
Sbjct: 264 RHFKKVE-RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE--------AAA 314
Query: 567 DFIINKTT----GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI--EVLPP 620
++ N G+I + + + T +L V A D N+ T++I L P
Sbjct: 315 RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAP 374
Query: 621 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTG 680
P++ L+Y ++ E +G V E I Y I +GD F++ G
Sbjct: 375 AEFERPKYTFLVYE-DVPEDSPIGTVKAREPLNSSE--PIFYRISSGDLGGKFSIHPRLG 431
Query: 681 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
+ K LD E+ +L + A G S+ VNI V DVNDN P F
Sbjct: 432 TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQ 491
Query: 741 EEEANAFVGQVKATDPDAGINGQVHYSLGNFN-NLFRI-TSNGSIYTAVKLNREVRDYYE 798
+ +A D D+G NG + YS+ + +F I + G ++ L +
Sbjct: 492 TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELT 551
Query: 799 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSP--VFTNSTYTVLVEENLPAGTTILQIEAK 856
L + A D VHP+ + L L + V++ ++SP F + Y V V E+L T +LQ +A
Sbjct: 552 LTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
Query: 857 DVD---LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF-D 912
+ + + Y + F + P+TG + L R DYE+ + F V A+
Sbjct: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES----TQTYNFRVFAWIP 666
Query: 913 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD------ 966
G + TV V V D ND P F + V V I + A D D
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQ 726
Query: 967 ---------------PPGLPASRV-----------------RYRVDDVQFPYPASIFEVE 994
P PA + + D++Q S+F E
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLF-CE 785
Query: 995 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ---- 1049
G +I V L+ E ++ V+ D G P +++ V + V + P F Q
Sbjct: 786 LGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 845
Query: 1050 -----EEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1104
+ PV+ L T T+ N + YS+ S + D F I+ G I
Sbjct: 846 KELHVKVLEGQPVNMLVT--TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTT 903
Query: 1105 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1164
L Y+ R SY + V+ + VP A V I++ + + +
Sbjct: 904 TILSYDYRPSY-------RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI 956
Query: 1165 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1224
+ E+ + + +K++D +Y+ + I+ K+G F +++ TG + +
Sbjct: 957 IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH--FEIDSSTGDLFLSKELDY 1014
Query: 1225 MRRSYFKFQVIATDDYGKGLSGKADVLVSV------------VNQLDMQVIVSNVP-PTL 1271
S++ F+VI T D+ K LS + V +S+ ++L + + NVP TL
Sbjct: 1015 ETTSHYLFRVITT-DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTL 1073
Query: 1272 V---EKKIED---LTEILDRYVQEQIPGAK--VVVESIGARRHGDAFSLEDYTKCDLTVY 1323
V K +D L + Y++ PG ++ S G E LTV
Sbjct: 1074 VYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVT 1133
Query: 1324 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYY 1357
A D N DR +LD+N D P +
Sbjct: 1134 ASDQAVN-VTDRRLRSLTAQIVILDVN-DHNPTF 1165
Score = 87.0 bits (214), Expect = 1e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 750 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 800
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
Query: 801 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 849
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
Query: 850 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 903
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
Query: 904 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 958
+ + P + + +D F +KG +K
Sbjct: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
Query: 959 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1018
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
Query: 1019 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 1072
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
Query: 1073 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
Query: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
Query: 1190 VMAYRLIIP 1198
++ Y + P
Sbjct: 514 LIRYSIASP 522
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 1047 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1106
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 1107 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1162
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 1163 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1215
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
Score = 54.3 bits (129), Expect = 1e-06
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 18/144 (12%)
Query: 660 ITYAIENG----DPQRVFNLSETTGILTLGKALDRESTDR-YILIITASDGRPDG----- 709
I Y++ +G + + F + G + + + +DRE Y L++ A DG
Sbjct: 92 IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLA 151
Query: 710 ------TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 763
++ A V + + DVNDN PVF+P E + + V ATD D+GI G
Sbjct: 152 LVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 211
Query: 764 VHYSL--GNFNNLFRITSNGSIYT 785
V Y L GN ++LF I S +Y+
Sbjct: 212 VAYELIPGNVSSLFTIDSTTGLYS 235
Score = 36.2 bits (82), Expect = 0.29
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 194
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 266 bits (680), Expect = 1e-70
Identities = 303/1145 (26%), Positives = 486/1145 (42%), Gaps = 112/1145 (9%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
Query: 318 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
Query: 377 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
G P + + ++++ + P F+ P Y E P G+ I + A D
Sbjct: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIG------IVKAVAAQD 2720
Query: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
I + P + + L+ T V V + P+D E + Y + A
Sbjct: 2721 PVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRK-----------PMDHESTKLYQIDVMA 2769
Query: 496 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
Query: 554 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 665
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
Query: 666 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 723
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
Query: 724 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 781
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
Query: 782 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 841
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
Query: 842 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 900
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
Query: 901 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 959
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
Query: 960 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1019
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
Query: 1020 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1074
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
Query: 1075 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1134
+N I YS++ GN+ F I+ G + V LD E +SY L+++A + P
Sbjct: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRA-------TDSGQP 3404
Query: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAY 1193
+ I++ D N++PP F + Y V E++ + + VL++ +D D+ N ++
Sbjct: 3405 PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSF 3464
Query: 1194 RLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1252
R I +G G T G + TA + +++ Q+ A+D LS V V
Sbjct: 3465 R-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRV 3519
Query: 1253 SVVNQ 1257
V Q
Sbjct: 3520 HVTEQ 3524
Score = 262 bits (670), Expect = 2e-69
Identities = 284/1088 (26%), Positives = 489/1088 (44%), Gaps = 121/1088 (11%)
Query: 142 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 201
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
Query: 202 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 261
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
Query: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
Query: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
Query: 382 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
H+E++ +EN P+F +QG + E++P G T + + A D D
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSG---------TQVIVVAAQDDD 1060
Query: 438 IEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 497
SG+ D EL FL T + + T + L P+DRE Y ++ A D
Sbjct: 1061 ------SGL---DGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111
Query: 498 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 555
V S V I+V DANDN P + + + D G SV+QL A D D S G+
Sbjct: 1112 RGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGK 1171
Query: 556 ITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 614
+T+ I G G F+I+ TGL++ A ++ + L V DN P+ + S V
Sbjct: 1172 LTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVV 1229
Query: 615 IEVLPPNNQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDP 669
+ +L N+ +PP F ++++ + E + + L A+D + +TY+IE+ D
Sbjct: 1230 VGILDVND-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD- 1287
Query: 670 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNA 726
+ F++ TG+++ + + IL I A+D G+P +++ ++I + +
Sbjct: 1288 EEAFSIDLVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSI 1345
Query: 727 PVFDPYLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGS 782
P+ + +V+E + N VG + G G +++ G+ + F I + GS
Sbjct: 1346 PLAFDETYYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGS 1401
Query: 783 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 842
I A L+ R Y L V TDG+ +T + +I+ + P F + Y V V +
Sbjct: 1402 IVIARPLDTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQ 1459
Query: 843 NLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPD 899
+ G +L+++A D D G ++ Y I + P F L P +G L + LD + P
Sbjct: 1460 DTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519
Query: 900 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 959
Q ++T +V +I + VT+ V+D N +PP F++ Y+ V GT +
Sbjct: 1520 QH-TLTVMVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQ 1576
Query: 960 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1019
V A DAD G+ A V Y + F + G + L++ L V
Sbjct: 1577 VRAMDAD-RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVK 1631
Query: 1020 AFDDGEPVMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
A D G P ATV I+ ++P + P F++ EY + E G+ + ++SA + ++
Sbjct: 1632 AEDQGSPQWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE 1689
Query: 1078 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137
+ Y + GN++ F +N+ +G+I LD+E +SY L+++ ++ ++
Sbjct: 1690 -VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV------ 1742
Query: 1138 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSV 1190
V ++I DEN++ P+F K ++G +SE A +++ ++ + A+D D S+
Sbjct: 1743 ---MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL 1799
Query: 1191 MAYRLIIP 1198
+ Y+++ P
Sbjct: 1800 LVYKILEP 1807
Score = 261 bits (666), Expect = 6e-69
Identities = 323/1214 (26%), Positives = 522/1214 (42%), Gaps = 148/1214 (12%)
Query: 82 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 136
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
Query: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
Query: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
Query: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
Query: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
Query: 435 DKDIEDVPPSGVPTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 492
D+D SG +D + +D + F + G T ++ +Q +D E QQ +
Sbjct: 2298 DQD------SG-RNRDVSYQIVEDGSDVSKFFQI--NGSTGEMSTVQELDYEAQQHFHVK 2348
Query: 493 ITAFDGVQESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 547
+ A D + +P +V + V D NDN P F + Y+ V G V+++ A+D
Sbjct: 2349 VRAMD---KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAID 2405
Query: 548 ADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER 606
D + Y IL G Q F IN ++G+I++ + + +Y L V A+D
Sbjct: 2406 PDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV----- 2460
Query: 607 RNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYA 663
+ VYI N S P F Q +Y E++E VG +++L A D++ +I Y
Sbjct: 2461 FRATVPVYINTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
Query: 664 IENGDPQRVFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTD 721
I N F+++ I TL K LDRE ST+R I I + A DG + TV I++TD
Sbjct: 2520 IINKLASEKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTD 2577
Query: 722 VNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS 779
NDN P F Y S V +++ V QV A D D G N V YS+ + + +
Sbjct: 2578 ENDNPPQFKASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIE 2635
Query: 780 NGSIYTAVK-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 832
+ VK L + D++ + A DG +S + + ++V+ + P F+
Sbjct: 2636 INPVTGVVKVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFS 2692
Query: 833 NSTYTVLVEENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 889
YT E+LP G+ I + A+D + + V F+L P TG + +
Sbjct: 2693 EPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVR 2752
Query: 890 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 949
+ +D+E+ + V A + T + +V + V D+ND PVF YK ++
Sbjct: 2753 KPMDHESTKLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTE 2808
Query: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
+ GT + V A D D +V YR+ +F ++ +SG + T L+ E
Sbjct: 2809 NMPVGTSVIQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCE 2866
Query: 1010 PTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMV 1067
+ VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V
Sbjct: 2867 TCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELV 2925
Query: 1068 GVISA-----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQ 1120
+ + N+ + I G+ FGI+ + ++ LD E Y+LRV
Sbjct: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT 2985
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
A + + V I + D N++ P + Y G V ED +L+V A
Sbjct: 2986 ASDGKF----------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSA 3035
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
TD DT + + Y L P G F ++ +TG + T R+ F ATD
Sbjct: 3036 TDLDTDTNAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD-- 3089
Query: 1241 GKGLSGKADVLVSV 1254
G G S +AD+ + V
Sbjct: 3090 GGGRSCQADITLHV 3103
Score = 259 bits (662), Expect = 2e-68
Identities = 306/1233 (24%), Positives = 513/1233 (41%), Gaps = 186/1233 (15%)
Query: 118 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 177
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
Query: 178 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 237
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
Query: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 297
A DR + ++E G+ G + V V P LR P
Sbjct: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
Query: 298 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 350
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
Query: 351 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 406
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
Query: 407 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTV 466
+ E +P G+ + +R+ +++ V + + LN T + T
Sbjct: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYV----LKPSSENVGFKLNARTGLITT 417
Query: 467 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 526
T+ +D ++ Y I G + +V I ++D N++ P F SY
Sbjct: 418 TKL-----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSY 463
Query: 527 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM- 585
D + ++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++
Sbjct: 464 DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYE 523
Query: 586 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 645
++ R Y V+A+D P R + +++++ L N + P F ++ + I + VG
Sbjct: 524 LMKRIYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGK 581
Query: 646 VLLNLQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIIT 701
++ + A D E ++ Y I +G+ F+L+ +G+++L + L Y L IT
Sbjct: 582 SIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKIT 641
Query: 702 ASDGRPDGTSTATVNIVVT----------------------------------------- 720
ASDG+ + S T+NI V
Sbjct: 642 ASDGK-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFT 700
Query: 721 -----DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFN 772
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN
Sbjct: 701 SLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEE 760
Query: 773 NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 831
F I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 761 GCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRF 820
Query: 832 TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 889
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL +
Sbjct: 821 PPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVT 878
Query: 890 RSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMV 947
LD E+ E VEA D G + + + ++D+ND P + V
Sbjct: 879 GHLDRES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKV 934
Query: 948 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 1007
D GT +T + + +DP PA VRY + D F V+ +G +I L+
Sbjct: 935 PEDLPPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELD 988
Query: 1008 EEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSEL 1060
E + L + A D G P+ + V+++V LHP F + V E
Sbjct: 989 FERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQEN 1044
Query: 1061 ATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1116
+ GT V V++A + ++ + Y + +G F IN TG+I PLD E + Y
Sbjct: 1045 SPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYW 1104
Query: 1117 LRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1175
L V A D V L S+ +VYIE+ D N++PP + + + EDA + TSV
Sbjct: 1105 LTVLAVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV 1156
Query: 1176 LRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1233
L++ A D D+ + + + I G F++ TGL+ TA + +
Sbjct: 1157 LQLDAWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILE 1211
Query: 1234 VIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
V D+ L + V+V +++ D I S+
Sbjct: 1212 VTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Score = 254 bits (650), Expect = 4e-67
Identities = 309/1173 (26%), Positives = 496/1173 (42%), Gaps = 130/1173 (11%)
Query: 120 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 179
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
Query: 180 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 239
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
Query: 240 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 299
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
Query: 300 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 359
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
Query: 360 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 419
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
Query: 420 SDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 479
D ++A+DKD SG P + + + F++ G + LQ
Sbjct: 2501 ID---------LLAIDKD------SG-PYGTIDYTIINKLASEKFSINPNG---QIATLQ 2541
Query: 480 PVDREE--QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 537
+DRE ++ + A DG V I + D NDN P F Y V + +++
Sbjct: 2542 KLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKD 2601
Query: 538 DSVIQLTAVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTV 595
VIQ+ A DADEG N ++TY + + IN TG++ + + + +T +
Sbjct: 2602 SPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFI 2661
Query: 596 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 655
+A D PP NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A
Sbjct: 2662 KAQDGGPP--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA 2718
Query: 656 EGDSITYAIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 709
+ D + Y++ G + VF+L TG++ + K +D EST Y + + A D
Sbjct: 2719 Q-DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDV 2777
Query: 710 TSTATVNIVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQV 764
S +VNI V DVNDN PVF DPY L N+ V V QV A D D G +GQV
Sbjct: 2778 VSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQV 2832
Query: 765 HYSL-----GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTL 817
Y L N + LF I S +G I T +L+ E Y VVA D G S +
Sbjct: 2833 SYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALV 2892
Query: 818 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVK 874
+ + D +DN+P F + Y V EN G + ++ D D+ V+ I +
Sbjct: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPL 2952
Query: 875 HFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 932
F + E +S ++L D+E + +L+ G + TV + V D+N
Sbjct: 2953 GQFGISQVGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVN 3005
Query: 933 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 992
D P S+ +Y G V D G I V A D D +++ Y + A F+
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFK 3059
Query: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1052
++ +G + T L+ E +F LV A D G + T+ + ++ PRF +
Sbjct: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSH 3117
Query: 1053 RPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1108
V + T T V V+ A N +VYS+ + E F I+ TGVI + PL
Sbjct: 3118 CAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQ 3176
Query: 1109 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1168
+ L V+A L + S V + + ++ PVF + V ED
Sbjct: 3177 VRPQAPLELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPED 3230
Query: 1169 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRR 1227
A T VL++ + + YR ++ ++G+ F ++ TG++ A L
Sbjct: 3231 APPGTEVLQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSP 3285
Query: 1228 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
YF ++ + K S +DV +VN D+
Sbjct: 3286 KYF----LSIECSRKSSSSLSDVTTVMVNITDV 3314
Score = 254 bits (648), Expect = 7e-67
Identities = 303/1182 (25%), Positives = 499/1182 (42%), Gaps = 156/1182 (13%)
Query: 146 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 204
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
Query: 205 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 264
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
Query: 265 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 324
D P F P YQ I E E+ I + D + D
Sbjct: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
Query: 325 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 382
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
Query: 383 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVP 442
L I + D N+ SP + + E P G ++ LD D+
Sbjct: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT------------FLDASDPDLG 955
Query: 443 PSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 499
P+G ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 956 PAG-----EVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
Query: 500 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 557
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
Query: 558 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 616
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Query: 617 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 673
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
Query: 674 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 728
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
Query: 729 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 780
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
Query: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 837
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
Query: 838 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 895
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 955
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
Query: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1013
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1069
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
Query: 1070 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1126
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
Query: 1127 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1186
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
Query: 1187 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1244
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Query: 1245 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1286
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
Score = 240 bits (612), Expect = 1e-62
Identities = 250/955 (26%), Positives = 419/955 (43%), Gaps = 129/955 (13%)
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
F ++ RT ++ + + DFH + + G A + I+I+D NN +P F
Sbjct: 406 FKLNARTGLITTTKLM--DFHDRAHYQLHIRTSPGQ---ASTVVVIDIVDCNNHAPLFNR 460
Query: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE-LHLFLNDYT 461
SY G + E+ P G TS L + A D+D + P+ L ++ Y
Sbjct: 461 SSYDGTLDENIPPG---------TSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYL 511
Query: 462 SVFTVTQTGITRYLTLLQPVDRE-EQQTYTFSITAFDG---VQESEPVIVNIQVMDANDN 517
+ + ++ P+D E ++ YTF + A D + + V + +Q+ + NDN
Sbjct: 512 GIISTSK-----------PMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDN 560
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGL 576
P F E++ + D G S++ ++A+D DE N + YEI+ G + ++ +N +G+
Sbjct: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGV 618
Query: 577 ITIA-PGVEMIVGR--TYALTVQAADN---APPA-------------------------- 604
I++ P + + G+ +Y+L + A+D A P
Sbjct: 619 ISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQ 678
Query: 605 ------------------ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 646
E S+ T I P Q FPQ S+++ E++ +
Sbjct: 679 FTKTILHFIGLQNQESSDEEFTSLSTYQINHYTP--QFEDHFPQ---SIDVLESVPINTP 733
Query: 647 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 703
L L ATD + + Y I +G+ + F++ TG+LT+ LD E+T+ YIL +T
Sbjct: 734 LARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVY 793
Query: 704 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 762
D G P +S + + V D NDNAP F P + + E + ++ D D+ NG
Sbjct: 794 DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNG 853
Query: 763 QVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAI 819
+V Y+L + F + G + L+RE Y L V A D H S L I
Sbjct: 854 RVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
Query: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH-FFA 878
+ D++DNSP + V E+LP GT + ++A D DLG R + H F
Sbjct: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFR 973
Query: 879 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND-- 933
+ TG L L R LD+E + A + A D G P T V VIV D+N+
Sbjct: 974 VDLMTGALILERELDFE----RRAGYNLSLWASD--GGRPLARRTLCHVEVIVLDVNENL 1027
Query: 934 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 993
+PP F+ +++G V ++ GT + V A+D D GL + ++ + F +
Sbjct: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGELQYF----LRAGTGLAAFSI 1082
Query: 994 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYR 1053
+D+G + T L+ E + + L V+A D G +SS V I V + P +
Sbjct: 1083 NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF 1142
Query: 1054 PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1109
P + E A GT V + A ++ + ++I SGN F I+ +TG++ LD
Sbjct: 1143 YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDR 1202
Query: 1110 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1169
E + ++ LEV + + PS +T++V + I D N++PP+F K + + E
Sbjct: 1203 ENKDEHI-------LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERL 1255
Query: 1170 RMFT--SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222
+ V R+ A+D D G + Y + +E F ++ TG++ ++ F
Sbjct: 1256 SPVSPGPVYRLVASDLDEGLNGRVTYSI----EDSDEEAFSIDLVTGVVSSSSTF 1306
Score = 234 bits (597), Expect = 6e-61
Identities = 281/1161 (24%), Positives = 483/1161 (41%), Gaps = 156/1161 (13%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
Query: 197 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
Query: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
Query: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
D + G+ + + F + T +S + L IKA
Sbjct: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
Query: 375 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 428
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
Query: 429 -LRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 487
I DKD++ F + +T T + + +P+D +
Sbjct: 1381 WFNISGGDKDMD------------------------FDIEKT--TGSIVIARPLDTRRRS 1414
Query: 488 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 547
Y ++ DG + + + + N + P F E Y+V V D PG ++++ A+D
Sbjct: 1415 NYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAID 1474
Query: 548 ADEGSNGEITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAP 602
D+G + + Y I G+ F ++ ++G++ +++ G + + LTV D
Sbjct: 1475 QDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEI 1532
Query: 603 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 659
P +R T+++E N PPRF QL Y + + + G LL ++A D +
Sbjct: 1533 PIKRNFVWVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAE 1589
Query: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 718
+ Y++ G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I
Sbjct: 1590 VHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIH 1649
Query: 719 VTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFN 772
V + +AP+F ++ VE + VG V A P +V Y L GN +
Sbjct: 1650 VYPSDRSAPIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKD 1700
Query: 773 NLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 831
+F + S +G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F
Sbjct: 1701 GVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMF 1758
Query: 832 TNSTYTVLVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPF 882
ST+ + E P + I+ I A D D AN + Y+I PE FF + P
Sbjct: 1759 LKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPS 1818
Query: 883 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSK 940
G L+++ +DYE+ P S F V D + P A V + V+D+ND PP FS+
Sbjct: 1819 MGTLTIVSEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874
Query: 941 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000
+IY+ + G + V A D D S V Y + +I V +G +
Sbjct: 1875 QIYEVAIVGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSI 1925
Query: 1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSE 1059
LN + + + + DG + +A VKI L + +F Q+ Y
Sbjct: 1926 SV---LNPAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKEN 1980
Query: 1060 LATKGTMVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYV 1116
L + +V ++ A +N ++ Y +++G D F + GV+ G D E + ++
Sbjct: 1981 LQDRKALV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHE 2037
Query: 1117 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
L V+ + + R P + V + I+D N++PP F+ Y + + +
Sbjct: 2038 LAVE-------VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF 2090
Query: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1236
+V ATD+D G + Y E F ++ Y G I F + + +VIA
Sbjct: 2091 QVSATDEDLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIA 2145
Query: 1237 TDDYGKGLSGKADVLVSVVNQ 1257
D L + +VLV+V N+
Sbjct: 2146 RDGGTPSLQSEEEVLVTVRNK 2166
Score = 230 bits (586), Expect = 1e-59
Identities = 252/930 (27%), Positives = 416/930 (44%), Gaps = 86/930 (9%)
Query: 359 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 417
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
Query: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
+ ++ A D ED+ +G T + F DYT G ++L
Sbjct: 2088 VL---------FQVSATD---EDLGTNGAVTYE-----FAEDYTYFRIDPYLGD---ISL 2127
Query: 478 LQPVDREEQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTD 533
+P D + Y + A DG +Q E V+V ++ N + P F Y V V +
Sbjct: 2128 KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPEN 2183
Query: 534 MRPGDSVIQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 590
+ ++ T + EG + E L+ DF TG++T+ ++
Sbjct: 2184 ITLYTPILH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTK 2238
Query: 591 YALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLN 649
+ TV+A D A S +EVL + N +PP F QL+Y+ ISE + ++
Sbjct: 2239 HVFTVRATDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQ 2293
Query: 650 LQATDREGD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 704
L A+D++ ++Y I + D + F ++ +TG ++ + LD E+ + + + A D
Sbjct: 2294 LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
Query: 705 -GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGING 762
G P T V + V+D+NDN P F P N+S + V +V+A DPD+
Sbjct: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTS 2412
Query: 763 QVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAI 819
++ Y + GN + F I S+ I + L ++ D Y L V A+DG +T+ + I
Sbjct: 2413 RLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYI 2469
Query: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFF 877
+ + SP F Y + EN GT ++ + A D D G + Y I + F
Sbjct: 2470 NTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKF 2529
Query: 878 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 937
+++P G+++ L+ LD E E I V A D G + TV +I+ D ND PP
Sbjct: 2530 SINP-NGQIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQ 2584
Query: 938 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997
F Y + + K +P+ V A DAD G A V Y V+ + E+ +
Sbjct: 2585 FKASEYTVSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVT 2640
Query: 998 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPP 1056
G V + +L + A D G P +S V++ V+ +P+F++ Y
Sbjct: 2641 GVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
Query: 1057 VSELATKGTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYET 1111
+L +G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+
Sbjct: 2701 PEDLP-EGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
Query: 1112 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1171
Y + V A L+ N V S V I++ D N++ PVF+ Y ++E+ +
Sbjct: 2760 TKLYQIDVMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPV 2812
Query: 1172 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1231
TSV++V A DKDTG ++YRL P E F +++ +G I T +
Sbjct: 2813 GTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYH 2872
Query: 1232 FQVIATDDYGK--GLSGKADVLVSVVNQLD 1259
F V+A D+G+ LS +A V VS+ ++ D
Sbjct: 2873 FHVVAY-DHGQTIQLSSQALVQVSITDEND 2901
Score = 219 bits (559), Expect = 1e-56
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 87/869 (10%)
Query: 116 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 174
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
Query: 175 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 234
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
Query: 235 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 294
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
Query: 295 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 354
P EL + T +Q+R + L + D R +S
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
Query: 355 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 414
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
Query: 415 VGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRY 474
G I L++ A D D + P H F D TG
Sbjct: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
Query: 475 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 534
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
Query: 535 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 594
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
Query: 595 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 654
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
Query: 655 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 712
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
Query: 713 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 766
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
Query: 767 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 823
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
Query: 824 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 880
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
Query: 881 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 938
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
Query: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADP 967
V D +G + ++A D DP
Sbjct: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
Score = 219 bits (558), Expect = 2e-56
Identities = 305/1199 (25%), Positives = 502/1199 (41%), Gaps = 151/1199 (12%)
Query: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 161
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
Query: 162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 220
+EL G V++ DP S DT + L+L+GN
Sbjct: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
Query: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 279
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
Query: 280 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 339
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
Query: 340 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 399
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
Query: 400 FTMPSYQGYILESAPVGATISDSLNLTSP-LRIVALDKDI---EDVPPSGVPTKDPELHL 455
F Y +I +++ SP ++++A D D DV S P + +
Sbjct: 2585 FKASEYT----------VSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVI 2634
Query: 456 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 513
+N T V V + + E QT F I A DG + V V +QV+
Sbjct: 2635 EINPVTGVVKVKDSLVGL-----------ENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP 2683
Query: 514 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGD 567
+ P F E Y D+ G + + AV A + + Y ++ G G
Sbjct: 2684 KKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGV 2739
Query: 568 FIINKTTGLITIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSP 625
F ++ TG+I + ++ + Y + V A N S+ +V I+V N+ P
Sbjct: 2740 FSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRP 2795
Query: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSET 678
F Y ++E M VG ++ + A D++ ++Y + + DP +F +
Sbjct: 2796 V-FEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSE 2853
Query: 679 TGILTLGKALDRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRN 736
+G +T + LD E+ Y + A D +S A V + +TD NDNAP F R
Sbjct: 2854 SGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
Query: 737 LSVVEEEANAFVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLN 790
V E V +K D D N QV + + G+ F I+ G I + L+
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
Query: 791 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 850
RE Y L V A+DG +++T+ I VLD++DNSP + YT V E++ G I
Sbjct: 2974 REHTAKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI 3030
Query: 851 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
L++ A D+D N ++Y + P H F L P TGEL+ L +LD E ++ +
Sbjct: 3031 LKVSATDLDTDTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVA 3085
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 968
+A D G A +T+ V+D+ND P F V + TP+ V+A D D
Sbjct: 3086 KATDGGGRSCQ--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQG 3143
Query: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV- 1027
++V Y + D + F ++ +G + L P +L V A D G P+
Sbjct: 3144 A--NAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP 3197
Query: 1028 MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYS 1082
+S+ TV + V+ + +P F E+ V E A GT V + A + + Y
Sbjct: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYR 3254
Query: 1083 IVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1142
+VSGNE+ F ++ TG++YVN LD+ET Y L ++ + S S+ V
Sbjct: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTV 3307
Query: 1143 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1202
+ I D N H P F + Y V E+A + +L V ATD+D S + Y LI
Sbjct: 3308 MVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----G 3362
Query: 1203 GKE--GFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
G + F + G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 3363 GNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
Score = 214 bits (545), Expect = 6e-55
Identities = 270/1078 (25%), Positives = 449/1078 (41%), Gaps = 110/1078 (10%)
Query: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
Query: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
Query: 260 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 318
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
Query: 319 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 378
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
Query: 379 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 438
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
Query: 439 EDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 498
G T ++ +Y F + +T L+ Q +DRE + + +T D
Sbjct: 1167 SS---KGKLT----FNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDN 1217
Query: 499 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNG 554
+ S V + ++D NDN P F ++V + + P V +L A D DEG NG
Sbjct: 1218 GEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNG 1277
Query: 555 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 614
+TY I + F I+ TG+++ + G LT++A D+ P ++ ++
Sbjct: 1278 RVTYSIEDSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLH 1333
Query: 615 IEVLP-PNNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 672
IE +P P S P F + YS + E V ++ + R G + I GD
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMD 1392
Query: 673 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDP 731
F++ +TTG + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLE 1450
Query: 732 YLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAV 787
+ + +V+A D D G + +H S +LF++ S+G + T
Sbjct: 1451 TRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVG 1510
Query: 788 KLN-REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 846
KL+ + L V+ D + + + + + I V D + + P FT Y V + +
Sbjct: 1511 KLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAP 1570
Query: 847 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 904
GT +LQ+ A D D G N V Y + + FF ++ G ++L + LD A
Sbjct: 1571 GTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPH 1626
Query: 905 TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 964
T V+A D +ATV + V + P+FSK Y + G+PI V A
Sbjct: 1627 TLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-- 1684
Query: 965 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1024
+ S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 1685 -----MSPSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMA 1736
Query: 1025 EPVMSSSATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----A 1074
V I + P F + + P S + K VI A+
Sbjct: 1737 GAFTDVMVVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKE 1795
Query: 1075 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRV 1133
N +VY I+ F I+ G + + +DYE+ S+ V D VL R
Sbjct: 1796 ANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR- 1854
Query: 1134 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1190
A+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1855 -----PAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
Score = 209 bits (531), Expect = 3e-53
Identities = 269/1135 (23%), Positives = 458/1135 (40%), Gaps = 137/1135 (12%)
Query: 135 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 190
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
Query: 191 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 249
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
Query: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
+ + V D +D P F I E+ ++P + +
Sbjct: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
Query: 310 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 369
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
Query: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
I+A GL YQ L + + SL +
Sbjct: 1941 IRASD----------GL------------------YQDTALVKISLTQVLDKSLQFDQDV 1972
Query: 430 RIVALDKDIED------VPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 483
A+ ++++D + G D + LN V G+ + T DR
Sbjct: 1973 YWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDR 2030
Query: 484 EEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
E+Q T+ ++ D Q +V + + D NDN P F + Y + PGD +
Sbjct: 2031 EQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF 2090
Query: 542 QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 601
Q++A D D G+NG +TYE F I+ G I++ + Y L V A D
Sbjct: 2091 QVSATDEDLGTNGAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGG 2149
Query: 602 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSIT 661
P+ + V + N+S P F Y + + E + + +L+ QA EG +
Sbjct: 2150 TPSLQSEEEVLVTV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLI 2204
Query: 662 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTD 721
Y I +P +F TG+LT+ LD ES +++ + A+D S ATV ++V D
Sbjct: 2205 YNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVED 2264
Query: 722 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI 777
VNDN P F + A V Q+ A+D D+G N V Y + + + F+I
Sbjct: 2265 VNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQI 2324
Query: 778 T-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
S G + T +L+ E + ++ + V A D P + + V DI+DN P F Y
Sbjct: 2325 NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384
Query: 837 TVLVEENLPAGTTILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
V E G +L+++A D D + + Y I S F ++ +G +S+
Sbjct: 2385 EANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKK 2444
Query: 895 EAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 952
++S V A D T+P I T + N Y P F + +Y+ +A +A+
Sbjct: 2445 HL----DSSYNLRVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAM 2495
Query: 953 KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT 1012
GT + + A D D P + Y + + SI +G++ T L+ E +T
Sbjct: 2496 VGTKVIDLLAIDKDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENST 2549
Query: 1013 --IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1069
+ + V+A D G V + TVKI++ + P+F EY S ++ ++ V
Sbjct: 2550 ERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQV 2607
Query: 1070 ISAAA---INQSIVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADS 1123
++ A N + YS+ + +D IN +TGV+ V L E +T + ++ Q
Sbjct: 2608 LAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG 2667
Query: 1124 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TD 1182
P ++ V +++ + P F + Y ED + + VKA
Sbjct: 2668 ---------PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA 2718
Query: 1183 KDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1236
+D YS++ R P + K+G F ++ TG+IK + ++ V+A
Sbjct: 2719 QDPVIYSLV--RGTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
Score = 197 bits (502), Expect = 6e-50
Identities = 278/1138 (24%), Positives = 472/1138 (41%), Gaps = 144/1138 (12%)
Query: 130 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 187
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
Query: 188 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 247
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
Query: 248 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
Query: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
Query: 368 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
Query: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 484
L + A D +D E++ + + VT +T +++L P
Sbjct: 1892 ----LMVRASD-------------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG 1934
Query: 485 EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 544
+ T I A DG+ + + +V I + D + F + Y V +++ +++ L
Sbjct: 1935 LSRKLT--IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILG 1991
Query: 545 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 604
A N ++Y +L G ++ L T + T+ L V+ DN P
Sbjct: 1992 A--QGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049
Query: 605 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYA 663
+ V IE + N +PP+F L Y I + G VL + ATD + G +
Sbjct: 2050 RVAQGLVRVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVT 2106
Query: 664 IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTD 721
E + F + G ++L K D ++ ++Y L + A DG GT + + ++VT
Sbjct: 2107 YEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTV 2163
Query: 722 VNDNAPVF-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFR 776
N + P+F PY +P N+++ + +A P+ G+ ++ Y++ L
Sbjct: 2164 RNKSNPLFQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLML 2215
Query: 777 ITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
T++ G + L+ E + + V ATD A+ S T+ + V D++DN P F+
Sbjct: 2216 FTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQ 2274
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLL 889
YT + E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S +
Sbjct: 2275 LVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTV 2334
Query: 890 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 949
+ LDYEA + V A D G V V V D+ND PP F + Y+ V+
Sbjct: 2335 QELDYEA----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSE 2390
Query: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
A G + V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 2391 LATCGHLVLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKK 2444
Query: 1010 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG 1068
+ V DG V ++ V I + + P F Q Y +ELA + MVG
Sbjct: 2445 HLDSSYNLRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVG 2497
Query: 1069 --VISAAAINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
VI AI++ +I Y+I++ + F IN G I LD E T V+ ++
Sbjct: 2498 TKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIK 2556
Query: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
+ + + V I + DEN++PP F+ Y + + + V++V A
Sbjct: 2557 VMARD-------GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609
Query: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
D D G + + Y + P K+ + TG++K + F + A D
Sbjct: 2610 YDADEGQNADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
Score = 175 bits (444), Expect = 3e-43
Identities = 196/760 (25%), Positives = 321/760 (42%), Gaps = 94/760 (12%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
Query: 198 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 254
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
Query: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
Query: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
Query: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV-A 433
G A LH+E D N+ +P F PS+ + D+ + +P+ +V A
Sbjct: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
Query: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
D D D F D T TG+ R L +P+ Q ++
Sbjct: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT-------TGVIR---LEKPLQVRPQAPLELTV 3187
Query: 494 TAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 550
A D + S V + V+ D P F + V V D PG V+QL +
Sbjct: 3188 RASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPG 3247
Query: 551 GSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 609
+ Y ++ G QG F ++ TG++ + ++ Y L+++ + + + +
Sbjct: 3248 AE--KTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSD 3303
Query: 610 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIEN 666
+ TV + + N P +FPQ YS + E VG V+L + ATD +G ITY++
Sbjct: 3304 VTTVMVNITDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIG 3362
Query: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
G+ F + G L + KALDRE Y L + A+D G+P + I V DVNDN
Sbjct: 3363 GNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDN 3422
Query: 726 APVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRIT 778
P F N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T
Sbjct: 3423 PPRF---FQLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
Query: 779 SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 838
+G + TA L+R +++Y+L + A+D + P S ++ + V + +P +
Sbjct: 3479 PDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFI 3538
Query: 839 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV--KHF 876
V E+ G + +I A D D ++Y + E +HF
Sbjct: 3539 TVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
Score = 127 bits (319), Expect = 1e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 766 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
Query: 886 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 944
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
Query: 945 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 1004
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
Query: 1005 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1061
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
Query: 1062 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
Query: 1122 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1181
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
Query: 1182 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1238
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
Score = 77.0 bits (188), Expect = 2e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 659 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 708
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
Query: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 768
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 769 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 825
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
Query: 826 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 870
S V T +TY TVLV+ N +G + +E D G
Sbjct: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
Query: 871 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 930
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
Query: 931 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 986
+ P F +I + P + + V + PPG VR V +
Sbjct: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
Query: 987 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1037
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
Query: 1038 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1093
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
Query: 1094 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1152
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
Query: 1153 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1212
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
Query: 1213 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1265
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 265 bits (677), Expect = 3e-70
Identities = 246/900 (27%), Positives = 415/900 (46%), Gaps = 88/900 (9%)
Query: 400 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLND 459
F MP+YQ + E+ P G I L L + I ++ + LF
Sbjct: 245 FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEG----------LFDER 291
Query: 460 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDN 517
F + T ++ +DRE ++T+ + A D S + + V D ND+
Sbjct: 292 SRGYFRIDSA--TGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 577
+P F + Y V ++ G V+ + A D D N + Y +L GA F +N+++G++
Sbjct: 350 SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVV 409
Query: 578 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 637
+ ++ Y L V+A D ++ TVYIEV N + P+F + Y +++
Sbjct: 410 STRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQV 468
Query: 638 SEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 694
E + + +L +QATDR+ +I Y+I +G+ F L +GIL + LD E
Sbjct: 469 PEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQ 528
Query: 695 RYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQV 751
+Y L I A DG P S+ V++ V DVNDN P+F P +V+E + V +
Sbjct: 529 KYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHI 587
Query: 752 KATDPDAGINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNR 791
+A D D+G N ++HY L + + F S+G I +L+R
Sbjct: 588 QAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDR 647
Query: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
E ++Y V A D P S+ +++I VLD++DN PVFT TY + + E+ G+++L
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
Query: 852 QIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVE 909
++A+D D + ++Y++ ++ FAL G ++L LDY+ QE V
Sbjct: 708 TLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVT 763
Query: 910 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 969
A D GT A V + V D N + PVF Y V+ D GT I T+ A D D
Sbjct: 764 ASD--GTR-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG- 819
Query: 970 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1029
+R+ Y + D P F ++ DSG + T + L+ E + L ++A D+G P S
Sbjct: 820 -ENARITYVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKS 873
Query: 1030 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1084
+ T++IL+L + P+F + Y+ + E A T + +SA + N ++Y+
Sbjct: 874 DTTTLEILILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQ 932
Query: 1085 SGNEED-TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKV 1142
G++ D F I +GVI LD E Y +L + + P+ S + ++
Sbjct: 933 GGDDGDGDFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEI 985
Query: 1143 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1202
+ I D N++ P+F+K V E+ + + V +++A D D G + + Y+++ E
Sbjct: 986 QVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----E 1040
Query: 1203 G--KEGFVVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
G + F ++ G ++ + L +RR Y V+ L +A V + +V+Q D
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
Score = 263 bits (671), Expect = 1e-69
Identities = 246/871 (28%), Positives = 394/871 (45%), Gaps = 112/871 (12%)
Query: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
ST VLDR+ V V Y + ++V+D ND+SP F+ Y V
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
E VG + T A+D D N + Y + + D F++ +G + R
Sbjct: 364 ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
Query: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
L+ E+ Y ++++AND+ +N + T T+ ++V D +D P F V
Sbjct: 413 AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
Query: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
++ PE++ +QA D+D+ I YSIL G
Sbjct: 466 -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 401
F++H + L ++ P++ + QK+ L IKA+ PL +G + +++LD N+ P F
Sbjct: 507 FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
Query: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
+Q +LE+ P+G + + I A+D D SG ++ LH L D
Sbjct: 567 SSPFQATVLENVPLGYPV---------VHIQAVDAD------SG---ENARLHYRLVDTA 608
Query: 462 SVFTVTQT-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 502
S F + + ++T+ +DREE + Y+F + A D S
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMS 668
Query: 503 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 562
V+I V+D NDN P F + +Y++ + D G SV+ L A D D +N ITY++
Sbjct: 669 SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTG 726
Query: 563 G-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 619
G + F ++ + GLIT+A ++ + Y L V A+D R+ V I V
Sbjct: 727 GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTD 781
Query: 620 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLS 676
N P F Y++ +SE VG + L A D E ITY I++ PQ F +
Sbjct: 782 ANTHRPV-FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRID 838
Query: 677 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPR 735
+G + LD E+ Y L I A D G P + T T+ I++ D NDNAP F +
Sbjct: 839 PDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898
Query: 736 NLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNR 791
+ + + QV ATD D+G NG++ Y+ + + ++G I T +L+R
Sbjct: 899 GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDR 958
Query: 792 EVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 850
E Y L +A D G+ P +++ + + +LDI+DN+P+F + VEEN P G+ +
Sbjct: 959 ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV 1018
Query: 851 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
+I A D D G N + Y+I +++HFF L G+L + LD+E +V
Sbjct: 1019 AKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVV 1074
Query: 909 EAFDIYGTMPPGI--ATVTVIVKDMNDYPPV 937
+A T P + ATV +++ D ND PPV
Sbjct: 1075 QA-----TSAPLVSRATVHILLVDQNDNPPV 1100
Score = 251 bits (640), Expect = 6e-66
Identities = 244/858 (28%), Positives = 388/858 (45%), Gaps = 96/858 (11%)
Query: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401
+F + T +S ++R+ + L +KA + P A + + + D N+ SP F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
Y+ + E+ VG + L I A D+D P + L
Sbjct: 355 QSEYRERVRENLEVGYEV---------LTIRASDRD--------SPINANLRYRVLGGAW 397
Query: 462 SVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDAND 516
VF + + +G+ +L DREE Y + A D + P+ V I+V D ND
Sbjct: 398 DVFQLNESSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDEND 454
Query: 517 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTG 575
N P F E +Y V V D+ +V+++ A D D+G N I Y IL G G F ++ +G
Sbjct: 455 NYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSG 514
Query: 576 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
++ + ++ + Y+L+++A D P NS V ++VL N+ + P F +
Sbjct: 515 ILDVINPLDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQA 572
Query: 636 EISEAMRVGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNL 675
+ E + +G ++++QA D + D+ + + G P F +
Sbjct: 573 TVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI 632
Query: 676 SETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYL 733
++G +T+ LDRE + Y + A D G P +S+ +V+I V DVNDN PVF P
Sbjct: 633 HNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTY 692
Query: 734 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVK 788
L+ + + V ++A D DA N + Y L GN N F ++S G I A+
Sbjct: 693 ELRLN-EDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
Query: 789 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 848
L+ + Y L V A+DG R T + I V D + + PVF +S YTV V E+ P GT
Sbjct: 750 LDYKQEQQYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
Query: 849 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 906
+I + A D D G N ++Y I+ P + F + P +G + + LDYE + + T
Sbjct: 807 SIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTL 860
Query: 907 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 966
+ A D T+ +++ D ND P F Y+G + DA T I V A D D
Sbjct: 861 TIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD 920
Query: 967 PPGLPASRVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 1023
P R+ Y DD F +E SG + T+ L+ E ++ L +A D
Sbjct: 921 SG--PNGRLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDR 973
Query: 1024 GEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1077
G P +S+S +++ +L + P F ++E V E G++V I A N
Sbjct: 974 GSPTPLSASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNA 1032
Query: 1078 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137
I+Y IV G+ F ++ + G + LD+E R YVL VQA S +V
Sbjct: 1033 QIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV---------- 1082
Query: 1138 NTAKVYIEIQDENNHPPV 1155
+ A V+I + D+N++PPV
Sbjct: 1083 SRATVHILLVDQNDNPPV 1100
Score = 234 bits (598), Expect = 4e-61
Identities = 229/821 (27%), Positives = 371/821 (45%), Gaps = 87/821 (10%)
Query: 521 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----VGAQGDFIINKTTGL 576
FP +Y V ++ + G ++QL A EG ++Y + ++G F I+ TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 577 ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 636
++ ++ T+ L V+A D + P + TV ++ N P F Q Y
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVK---DTNDHSPVFEQSEYRER 361
Query: 637 ISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDREST 693
+ E + VG +L ++A+DR+ ++ Y + G VF L+E++G+++ LDRE
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA 420
Query: 694 DRYILIITASD-GRPDG--TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE---ANAF 747
Y L++ A+D GR G ++TATV I V D NDN P F +N V E N
Sbjct: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFS---EQNYVVQVPEDVGLNTA 477
Query: 748 VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVAT 804
V +V+ATD D G N +HYS+ GN F + S I + L+ E Y L + A
Sbjct: 478 VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
Query: 805 DGAVHPR-HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 863
DG P +S+ ++++VLD++DN P+F +S + V EN+P G ++ I+A D D G N
Sbjct: 538 DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 864 VSYRIR-------------------SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 904
R +P F +H +G +++ LD E +
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE----EVEHY 653
Query: 905 TFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
+F VEA D +G+ P +T V++ V D+ND PVF++ Y+ + DA G+ + T+ A
Sbjct: 654 SFGVEAVD-HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
Query: 964 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 1023
D D + ++ +F + + G + + L+ + + L V A D
Sbjct: 713 DRDANSVITYQLTGGNTRNRFALSS-----QRGGGLITLALPLDYKQEQQYVLAVTASDG 767
Query: 1024 GEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSI 1079
S +A V I V Q + VSE GT + +SA N I
Sbjct: 768 ---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARI 824
Query: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1139
Y V + F I+ +G +Y LDYE + +Y L + A + +P KS+T
Sbjct: 825 TY--VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQ-------DNGIPQKSDT 875
Query: 1140 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1199
+ I I D N++ P F FY G + EDA TS+L+V ATD+D+G + Y
Sbjct: 876 TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLY--TFQG 933
Query: 1200 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSVVNQL 1258
+G F +E +G+I+T + + +A D LS ++ V++++
Sbjct: 934 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD-- 991
Query: 1259 DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1299
I N P + EK + L+ +V+E P VV +
Sbjct: 992 ----INDNAP--MFEK------DELELFVEENNPVGSVVAK 1020
Score = 162 bits (411), Expect = 2e-39
Identities = 196/781 (25%), Positives = 321/781 (41%), Gaps = 100/781 (12%)
Query: 86 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVG---TIIYHE--VRI 140
+ Y +L V +L+S +LD P++ + I + G +I V +
Sbjct: 494 IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 141 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI---- 196
V D NDN P F + ATV E P+G + A D D G N ++ Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVV-----HIQAVDADSGENARLHYRLVDTA 608
Query: 197 -------QYNPDDPTSNDTFEIPLM-LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 248
P +P F + +G I + L+ E+ Y ++A D +
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG---SP 665
Query: 249 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 308
+++T++++ VLD +D P+F +P TY ELR E+
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFT-----------QP-TY-----ELRLNEDAAVGSSVLT 708
Query: 309 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL-SLLEPVNRDFHQKFD 367
+QA D+D N I Y + G + RF R L +L P++ Q++
Sbjct: 709 LQARDRDANSV-------ITYQLTGGNTRN--RFALSSQRGGGLITLALPLDYKQEQQYV 759
Query: 368 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
L + A A + I + D N P F Y + E PVG +I+
Sbjct: 760 LAVTASDGTRSHT---AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT------ 810
Query: 428 PLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 487
+ A D+D + + + + D F + T Y + +D E Q
Sbjct: 811 ---LSANDEDTGE---------NARITYVIQDPVPQFRIDPDSGTMYT--MMELDYENQV 856
Query: 488 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 545
YT +I A D Q+S+ + I ++DANDN P F Y ++ D P S++Q++A
Sbjct: 857 AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSA 916
Query: 546 VDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 603
D D G NG + Y G GDF I T+G+I ++ Y L A D P
Sbjct: 917 TDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 976
Query: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSI 660
S+ + + +L N+ + P F + L + E VG+V+ ++A D + I
Sbjct: 977 TPLSASV-EIQVTILDINDNA-PMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQI 1034
Query: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Y I GD + F L G L LD E Y+L++ A+ S ATV+I++
Sbjct: 1035 MYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA--PLVSRATVHILLV 1092
Query: 721 DVNDNAPVFDPYLPRNLSVVEEEANAF----VGQVKATDPDAGINGQVHYSLGNFNNLFR 776
D NDN PV + + V ++N+F +G + A DPD ++ ++Y+ N L R
Sbjct: 1093 DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNEL-R 1149
Query: 777 ITSNGSIYTAVKLNREV---RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
+ ++L+R++ R L+ V+ +H + TL + ++ D + TN
Sbjct: 1150 LLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDD----MLTN 1205
Query: 834 S 834
S
Sbjct: 1206 S 1206
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 224 bits (572), Expect = 4e-58
Identities = 252/941 (26%), Positives = 400/941 (42%), Gaps = 120/941 (12%)
Query: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
FH+HP T + ++R+ + V L A + I + D N+ SP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 403 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS 462
S Q + E +P G + P + + V PS +P KDP F Y +
Sbjct: 170 DSLQLDVSELSPPGTAFRLPV-AHDPDAGLFSTQGYTLVQPSDLP-KDPAGPFFQLRYRT 227
Query: 463 VFTVTQTGITRY--------LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVM 512
+ + L LL+ +DREE + I A+DG + + + V ++V+
Sbjct: 228 PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVL 287
Query: 513 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV---------- 562
D NDN P F + Y V D +PG V ++ A D D G NG + Y +
Sbjct: 288 DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
Query: 563 GAQGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 619
GA GD F + + +G++ + ++ + L V+A D AE + V I VL
Sbjct: 348 GALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVRVSIAVLD 405
Query: 620 PNNQSPPRFPQLMYS---LEISEAMRVGAVLLNLQATDREGD------------------ 658
N+ P + +SE R G + + +D +GD
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
Query: 659 SITYAIENGDPQRVFNLSETTGI--LTLGKALDRESTDRYILIITASD-GRPDGTSTATV 715
SI+ ++E G+ G+ L + LDRES D Y L++ A+D G P ++ T+
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 716 NIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG-----------INGQ 763
+ V D+ND P+F SV E A V V A+D D +
Sbjct: 526 LLRVADLNDQPPLFSQQ-HYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 764 VHYSLGNFNN----------LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRH 812
+LG+ + F I S +G+I T L+REV++ EL VVA D P
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 813 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI-- 868
+T ++I V D++DN P+F Y + E+ P G LQ+ A D D G + Y +
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
Query: 869 --RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 926
S E F + P G++ + + +D E P A+ LVEA D G A V V
Sbjct: 705 GFLSYEAPQAFRIDPHDGQICVSQDIDRERDP---ATYDLLVEAKDGGGLSAQ--AFVRV 759
Query: 927 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 986
++D+ND PVF+ Y ++ + GT I V A D D G+ + V Y +
Sbjct: 760 DLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD-SGIYGT-VAYELIPGNV-- 815
Query: 987 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSSATVKIL--VLHPG 1042
+S+F ++ +G + + L+ +T L+V A D G V+++ T+ I L P
Sbjct: 816 -SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
Query: 1043 EI--PRFTQEEYRPPPVSELATKGTMVGVISA-AAINQS--IVYSIVSGNEEDTFGINNI 1097
E P++T Y P + + +G + A +N S I Y I SG+ F I+
Sbjct: 875 EFERPKYTFLVYEDVP------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPR 928
Query: 1098 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1157
G I PLD+ET+ VL VQ A L ++ +V I + D N++ P F
Sbjct: 929 LGTIRTRKPLDHETQPVVVLTVQ--------AQLGSAPACSSTEVNITVMDVNDNHPAFL 980
Query: 1158 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1198
+ +S+ T++ +A D+D+G ++ Y + P
Sbjct: 981 RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
Score = 204 bits (519), Expect = 6e-52
Identities = 300/1217 (24%), Positives = 488/1217 (40%), Gaps = 167/1217 (13%)
Query: 130 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 181
+G ++ E+R V D ND+SP F +S V+EL+P GT + D A
Sbjct: 147 LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204
Query: 182 -----TDIDDGPNGQIEYVIQY-------NPDDPTSNDTFEIPLMLTGNIVLRKRLNYED 229
+D+ P G + ++Y +P P S+ E PL ++VL +RL+ E+
Sbjct: 205 TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLE-PL----DLVLLRRLDREE 258
Query: 230 KTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQA 289
+ + I+A D + RRT ++ + VLD +D P+F Y+A
Sbjct: 259 AAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVF------------EQDEYRA 303
Query: 290 AIPELRTPEELNPIIVTPPIQAIDQD-----------RNIQPPSDRPGILYSILVGTPED 338
A+ E+ P ++A D+D R Q P G G
Sbjct: 304 AV-----REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG-------GGALG 351
Query: 339 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 398
+F + + + + P++R+ LV++A P A + I +LD N+ P
Sbjct: 352 DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
Query: 399 ----YFTMPSYQGYILESAPVG-----ATISDSLNLTSPLRIVALDKDIEDVPPSGVPTK 449
F + E A G ++SD+ +K+ E GV
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADG--------DWEKEDEATGELGVGLG 463
Query: 450 DPELHLFLNDYTSVFTVTQTGI--TRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPV 505
D + L L F + G +L + P+DRE + Y + A D S
Sbjct: 464 DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE 523
Query: 506 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN------------ 553
+ ++V D ND P F + Y V PG V+ ++A DADE +
Sbjct: 524 TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
Query: 554 ------GEITYEILVGAQ--GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 605
G + +++ A+ F I+ +G I+ ++ V L V A D P
Sbjct: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP- 642
Query: 606 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITY 662
++ C V I V N + P F + +Y+ I+E VG L + A+D + I Y
Sbjct: 643 -LSATCLVSITV-DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
Query: 663 AIENG----DPQRVFNLSETTGILTLGKALDRE-STDRYILIITASDGRPDGTST-ATVN 716
++ +G + + F + G + + + +DRE Y L++ A DG G S A V
Sbjct: 701 SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFVR 758
Query: 717 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 774
+ + DVNDN PVF+P E + + V ATD D+GI G V Y L GN ++L
Sbjct: 759 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
Query: 775 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
F I S G IY + L+ L+V A DG + I + F
Sbjct: 819 FTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFER 878
Query: 834 STYTVLVEENLPAGTTILQIEAKD-VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 892
YT LV E++P + I ++A++ ++ + YRI S ++ F++HP G + + L
Sbjct: 879 PKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL 938
Query: 893 DYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPDA 951
D+E P + V+A G+ P +T V + V D+ND P F + + ++
Sbjct: 939 DHETQP----VVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 952 VKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
GT + AED D GL +RY + Q +F ++ G + +L
Sbjct: 993 PPGTALYLARAEDRDSGRNGL----IRYSIASPQ----PGVFAIDRALGVLFLNGSLGAG 1044
Query: 1010 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE---------EYRPPPVSEL 1060
L + A D G ++ + +++ P +T E E P L
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQML 1104
Query: 1061 ATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1120
T+ +G AA+ + YS+ + FGI TG IY+ DYE+ +Y RV
Sbjct: 1105 QTQAHPLGPQRAAS---PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161
Query: 1121 ADSLE-VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1179
A E L N+ + V + + DEN++ P F V E + ++
Sbjct: 1162 AWIPEDGFLQNV-------STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKIT 1214
Query: 1180 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1239
A D D+G + Y L + +GK F + TG + + R + + V+ TD
Sbjct: 1215 AIDMDSGKNGQLLYFL----LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
Query: 1240 YGKGLSGKADVLVSVVN 1256
+ V VSV +
Sbjct: 1270 GSPPRNATMAVYVSVTD 1286
Score = 185 bits (469), Expect = 4e-46
Identities = 210/788 (26%), Positives = 316/788 (40%), Gaps = 84/788 (10%)
Query: 103 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162
ST R LDR+ + VV + V I V D NDN P F + Y AT+
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673
Query: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
E PVG A+D D G G IEY + + F I G I +
Sbjct: 674 EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH-DGQICVS 727
Query: 223 KRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 281
+ ++ E D Y ++++A D + + VD+ D +D P+F P V + D
Sbjct: 728 QDIDRERDPATYDLLVEAKDGGG-----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
Query: 282 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
E P + A DQD I + Y ++ P +
Sbjct: 783 -----------------ETQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSS 817
Query: 342 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401
F + T + L P++ L++ A+ G A + I I F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 402 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
P Y + E P SP+ V + + P +L + +
Sbjct: 878 RPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
Query: 462 SVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPT 520
+ T+ TR +P+D E Q ++ A G + VNI VMD NDN P
Sbjct: 928 RLGTIR----TR-----KPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978
Query: 521 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIA 580
F S ++ + PG ++ A D D G NG I Y I G F I++ G++ +
Sbjct: 979 FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLN 1038
Query: 581 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISE 639
+ R LT++A D + + TV IE SP F L+Y +E+SE
Sbjct: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSE 1095
Query: 640 AMRVGAVLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDR 695
++ +L QA R + Y++E +F + TG + L + D EST
Sbjct: 1096 SLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQT 1155
Query: 696 YILIITA---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVG 749
Y + A DG ST TV + V D NDN+P F L L + EE+ +G
Sbjct: 1156 YNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIG 1211
Query: 750 QVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAV 808
++ A D D+G NGQ+ Y L + F++ N G + V L+RE R ++E+ V+ TD
Sbjct: 1212 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGS 1271
Query: 809 HPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--A 862
PR++T+ + + V DI+DN P F V V E P + + AKD D G A
Sbjct: 1272 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 1331
Query: 863 NVSYRIRS 870
V+Y + S
Sbjct: 1332 EVTYSVSS 1339
Score = 181 bits (459), Expect = 6e-45
Identities = 269/1138 (23%), Positives = 460/1138 (40%), Gaps = 166/1138 (14%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDN P F+ + Y A V E G + ATD D GPNG + Y ++
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336
Query: 198 YNP-------DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
+ + L+G + + + L+ E + + ++++A D E
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA---EPE 393
Query: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTP 307
T +++ VLD D RP + + E R E P
Sbjct: 394 VATVRVSIAVLD----------------VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
Query: 308 PIQAIDQDRNIQPPSDRPGILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPV 358
+ D D + + + G L SI L G D+ P L + P+
Sbjct: 438 RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
Query: 359 NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 418
+R+ ++L++ A PL L + + D N+Q P F+ Y+ + E+A G
Sbjct: 498 DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
Query: 419 I-----SDS--------------LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLND 459
+ SD+ + L++P + +L + G
Sbjct: 558 VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG-------------- 603
Query: 460 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDN 517
S +++G ++ ++ +DRE Q+ + A D + S +V+I V D NDN
Sbjct: 604 -PSFAIDSESGA---ISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDN 659
Query: 518 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-----AQGDFIINK 572
P F Y+ + G +Q+TA DAD G G I Y + G A F I+
Sbjct: 660 EPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 719
Query: 573 TTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQ 630
G I ++ ++ TY L V+A D + + ++ V L N + P F
Sbjct: 720 HDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ------AFVRVDLEDVNDNHPVFNP 773
Query: 631 LMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKA 687
Y IS+ + G ++N+ ATD++ ++ Y + G+ +F + TTGI+ L
Sbjct: 774 STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
Query: 688 LDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVV 740
L + L+++A DG G TA +N VT +F L P+ +V
Sbjct: 834 LSHLESTTLSLMVSAQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLV 885
Query: 741 EEEA--NAFVGQVKATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRD 795
E+ ++ +G VKA +P + + Y S G+ F I G+I T L+ E +
Sbjct: 886 YEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
Query: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 855
L V A G+ P S+ + I V+D++DN P F ++ + + + P GT + A
Sbjct: 945 VVVLTVQAQLGSA-PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003
Query: 856 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 913
+D D G N + Y I SP+ FA+ G L L SL ++ +T + A D
Sbjct: 1004 EDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED- 1057
Query: 914 YGTMPPGIATVTVIVKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PG 969
G P V +V + ++ P F +Y+ V+ +P+T + A P P
Sbjct: 1058 QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQ 1114
Query: 970 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPV 1027
AS +RY ++ +++F + +G + R + E T + V A+ +DG +
Sbjct: 1115 RAASPLRYSLEP---SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-L 1170
Query: 1028 MSSSATVKILVLHPGE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIV 1080
+ S TV + V + P F + E P P + G + + + N ++
Sbjct: 1171 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLL 1227
Query: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Y ++S + F +N TG + LD E R + + V++ + P ++ T
Sbjct: 1228 YFLLSDGK--FFKMNPNTGELINWVALDREHRGHH-------EMTVLVTDRGSPPRNATM 1278
Query: 1141 KVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1193
VY+ + D N++ P F K+ ++ V E + V V A D D GN + + Y
Sbjct: 1279 AVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Score = 178 bits (451), Expect = 5e-44
Identities = 237/972 (24%), Positives = 387/972 (39%), Gaps = 95/972 (9%)
Query: 106 RVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPT----FKHESYYA 159
R LDR+ H +VV+ + +V T+ V I V D NDN P F E A
Sbjct: 369 RPLDREAQA-WHQLVVEARDGGAEPEVATV---RVSIAVLDVNDNRPAIHVLFLTEGGVA 424
Query: 160 TVNELTPVGTTIF-TGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 218
V+E G + S +G + +D G++ + + +L G
Sbjct: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
Query: 219 ------IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLP 272
+ + L+ E + Y +++ A D + +T TL + V D +D P+F
Sbjct: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAG---SPPLSTEETLLLRVADLNDQPPLF-- 539
Query: 273 CVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR--------NIQPPSDR 324
Y+A++ E P + + D + P +
Sbjct: 540 ----------SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
Query: 325 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFA 384
G L S +V T E P F + + +S + ++R+ + +L + A+ PL A
Sbjct: 590 -GSLQSKMVHTAECGPSFA-IDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATC 647
Query: 385 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------I 438
+ I + D N+ P F Y I E APVG L++ A D D I
Sbjct: 648 LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCF---------LQVTASDADSGLYGFI 698
Query: 439 EDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE-EQQTYTFSITAFD 497
E G + + ++ + V+Q +DRE + TY + A D
Sbjct: 699 EYSLYDGFLSYEAPQAFRIDPHDGQICVSQD-----------IDRERDPATYDLLVEAKD 747
Query: 498 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 557
G S V + + D NDN P F +Y + + +PG +I + A D D G G +
Sbjct: 748 GGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVA 807
Query: 558 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI- 615
YE++ G F I+ TTG+I + + + T +L V A D N+ T++I
Sbjct: 808 YELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
Query: 616 -EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFN 674
L P P++ L+Y ++ E +G V + + I Y I +GD F+
Sbjct: 868 QTTLAPAEFERPKYTFLVYE-DVPEDSPIGTV--KAREPLNSSEPIFYRISSGDLGGKFS 924
Query: 675 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLP 734
+ G + K LD E+ +L + A G S+ VNI V DVNDN P F
Sbjct: 925 IHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSD 984
Query: 735 RNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN-NLFRI-TSNGSIYTAVKLNRE 792
+ +A D D+G NG + YS+ + +F I + G ++ L
Sbjct: 985 EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAG 1044
Query: 793 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP--VFTNSTYTVLVEENLPAGTTI 850
+ L + A D VHP+ + L L + V++ ++SP F + Y V V E+L T +
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
Query: 851 LQIEAKDVD---LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 907
LQ +A + + + Y + F + P+TG + L R DYE+ + F
Sbjct: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES----TQTYNFR 1159
Query: 908 VEAF-DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 966
V A+ G + TV V V D ND P F + V V I + A D D
Sbjct: 1160 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 1219
Query: 967 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
G + + + D +F F++ ++G +I V L+ E ++ V+ D G P
Sbjct: 1220 -SGKNGQLLYFLLSDGKF------FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSP 1272
Query: 1027 VMSSSATVKILV 1038
+++ V + V
Sbjct: 1273 PRNATMAVYVSV 1284
Score = 147 bits (372), Expect = 7e-35
Identities = 185/746 (24%), Positives = 315/746 (42%), Gaps = 122/746 (16%)
Query: 643 VGAVLLNLQATDREGDSITYAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILI 699
VG + L A ++ S + E+ D + F++ TGI+ + LDRE D Y +
Sbjct: 83 VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFV 142
Query: 700 ITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDA 758
G + V I V DVND++P F L ++S + AF V A DPDA
Sbjct: 143 AATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPV-AHDPDA 196
Query: 759 GINGQVHYSLGNFNNL----------FRITSNGSIYTAV-----------------KLNR 791
G+ Y+L ++L R + G + + + +L+R
Sbjct: 197 GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDR 256
Query: 792 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 851
E + L + A DG R L++ ++VLD +DN PVF Y V E+ G +
Sbjct: 257 EEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVC 316
Query: 852 QIEAKDVDLGAN--VSYRIRSPEV------------KHFFALHPFTGELSLLRSLDYEAF 897
++ A D DLG N V Y +R+ +V +FA+ +G + + R LD EA
Sbjct: 317 RVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREA- 375
Query: 898 PDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP----VFSKRIYKGMVAPDA 951
+A +VEA D G P +AT V++ V D+ND P +F V+ A
Sbjct: 376 ---QAWHQLVVEARD--GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430
Query: 952 VKGTPITTVYAEDADPP-------------GLPASRVRYRVDDVQFPY------PASIFE 992
G + V DAD GL + ++ + + P +F
Sbjct: 431 RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVF- 489
Query: 993 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1052
+ L+ E +++L++VA D G P +S+ T+ + V + P +++
Sbjct: 490 ------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
Query: 1053 RPPPVSELATKGTMVGVISAAAINQS------IVYSIVS-------GNEED--------- 1090
VSE A GT+V +SA+ +++ + Y++V G+ +
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
Query: 1091 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1149
+F I++ +G I LD E + +A L+VV +L P S T V I + D
Sbjct: 604 PSFAIDSESGAISTIRTLDREVQ-------EAVELKVVAQDLGEPPLSATCLVSITVDDV 656
Query: 1150 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK-EGKEGFV 1208
N++ P+F ++ Y ++E A + L+V A+D D+G Y + Y L + E + F
Sbjct: 657 NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 1209 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS-NV 1267
++ + G I + + R + ++ G GLS +A V V + + D + + +
Sbjct: 717 IDPHDGQICVSQDI-DRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 1268 PPTLVEKKIEDLTEILDRYVQEQIPG 1293
T + + + TEI++ +Q G
Sbjct: 776 YVTSISDETQPGTEIINVLATDQDSG 801
Score = 51.6 bits (122), Expect = 7e-06
Identities = 95/403 (23%), Positives = 164/403 (40%), Gaps = 85/403 (21%)
Query: 35 EDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 89
++ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 984 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 1025
Query: 90 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 1026 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 1078
Query: 149 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 205
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 1129
Query: 206 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 261
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 1130 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 1182
Query: 262 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 321
D +D P FL VL L+ E P V I AID D
Sbjct: 1183 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMD------ 1219
Query: 322 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 381
S + G L L+ +FF M+P T EL ++R+ ++ + P
Sbjct: 1220 SGKNGQLLYFLLSDG----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRN 1275
Query: 382 AFAGLHIEILDENNQSPYF--TMPSYQGY--ILESAPVGATIS 420
A +++ + D N+ P+F +P + + +LE PV ++
Sbjct: 1276 ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT 1318
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 475 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 532
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 533 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 588
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 589 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 647
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 648 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 704
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 705 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 761
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 762 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 820
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 821 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 880
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 881 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 938
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 939 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 994
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 995 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 630 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 680
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 681 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 726
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 727 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 781
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 782 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 837
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 838 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 892
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 893 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 952
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 953 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 1002
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 1003 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1062
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1063 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1118
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1119 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1239 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1289
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 180 bits (456), Expect = 1e-44
Identities = 166/570 (29%), Positives = 256/570 (44%), Gaps = 71/570 (12%)
Query: 354 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 411
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 412 SAPVGATISDSLNLTSPLRIVALDKDI----EDVPPSGVPTKDPELHLF-LNDYTSVFTV 466
+APVG TS +++ A D DI E G LF LN+ T + TV
Sbjct: 264 NAPVG---------TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 467 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------ 520
++ +DREE + ++ A DG V I V D NDN P
Sbjct: 315 QRS-----------LDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 521 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINK 572
I+ VY+ + +T D D NG E+ + + +++ +
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-E 422
Query: 573 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 632
T+ L+ E ++ + A+D+ P+ + ++ V +E N +PP F Q +
Sbjct: 423 TSSLLDYEGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPV 473
Query: 633 YSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
L +SE R G L + ATD + G + + G F+L TG+LT + DRE
Sbjct: 474 IELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE 533
Query: 692 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEAN 745
+R+I +TA D G P S A V + V D NDN+P F ++ NL
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKY 588
Query: 746 AFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVAT 804
+ VG + TD DAG N V S+ N N+ F + +G I + V +RE + Y V AT
Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 805 DGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDL 860
DG PR ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDT 707
Query: 861 GAN--VSYRIRSPEVKHFFALHPFTGELSL 888
G N + Y I S K F + P TG ++L
Sbjct: 708 GMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 6e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 565
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 566 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 620
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 621 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 674
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 675 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 733
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 734 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 785
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 786 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 845
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 846 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 905
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 906 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 964
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 965 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1024
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1025 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1075
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVI 1101
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 142 bits (357), Expect = 4e-33
Identities = 171/658 (25%), Positives = 288/658 (43%), Gaps = 73/658 (11%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 197 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 431
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 432 VALDKDIEDVPPSGVPTKDPELHLFLND-YTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
DKD DV + + E+ L Y + + + + + +D E + ++
Sbjct: 387 TVSDKD-TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL---------LDYEGTKEFS 436
Query: 491 FSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
F I A D + S + +V +++ D NDN P F + ++ V + R G + ++A D
Sbjct: 437 FKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDE 496
Query: 549 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 608
D G N +I Y++ A F +++ TG++T + + + TV A DN P
Sbjct: 497 DSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQ 553
Query: 609 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIE 665
S V + VL N+ S P+F + +SE + + + + TD E ++T +I
Sbjct: 554 SQAAVIVTVLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL 612
Query: 666 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 724
N + F L +G++ + DRE Y + A+D G+P +STA V I V DVND
Sbjct: 613 NDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670
Query: 725 NAP-VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 777
N+P V P + +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 671 NSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 95.9 bits (237), Expect = 3e-19
Identities = 85/317 (26%), Positives = 136/317 (42%), Gaps = 45/317 (14%)
Query: 283 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 342 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVI 506
+ + L+ Y+ V + DRE+Q +YTF + A DG Q S
Sbjct: 612 LNDNDNFVLDPYSGVIKSNVS-----------FDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 507 VNIQVMDANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 563
V I VMD NDN+P P + V PG V ++ AVD D G N E+ Y I+ G
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 564 -AQGDFIINKTTGLITI 579
+G F I+ TG IT+
Sbjct: 721 NNKGLFRIDPVTGNITL 737
Score = 47.8 bits (112), Expect = 1e-04
Identities = 63/245 (25%), Positives = 101/245 (41%), Gaps = 44/245 (17%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE---PVNRDFHQKFDLVIKAEQ 374
+ + Y+I+ G + F + P T ++L E P + H+ LV+
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEEKPAPTDVGLHR---LVVNI-S 756
Query: 375 DNGHP 379
D G+P
Sbjct: 757 DLGYP 761
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 475 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 532
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 533 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 588
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 589 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 647
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 648 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 704
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 705 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 761
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 762 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 820
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 821 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 880
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 881 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 938
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 939 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 994
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 995 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 630 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 680
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 681 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 726
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 727 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 781
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 782 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 837
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 838 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 892
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 893 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 952
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 953 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 1002
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 1003 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1062
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1063 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1118
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1119 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1178
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1239 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1289
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 180 bits (456), Expect = 1e-44
Identities = 166/570 (29%), Positives = 256/570 (44%), Gaps = 71/570 (12%)
Query: 354 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 411
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 412 SAPVGATISDSLNLTSPLRIVALDKDI----EDVPPSGVPTKDPELHLF-LNDYTSVFTV 466
+APVG TS +++ A D DI E G LF LN+ T + TV
Sbjct: 264 NAPVG---------TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV 314
Query: 467 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------ 520
++ +DREE + ++ A DG V I V D NDN P
Sbjct: 315 QRS-----------LDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 521 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINK 572
I+ VY+ + +T D D NG E+ + + +++ +
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-E 422
Query: 573 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 632
T+ L+ E ++ + A+D+ P+ + ++ V +E N +PP F Q +
Sbjct: 423 TSSLLDYEGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPV 473
Query: 633 YSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
L +SE R G L + ATD + G + + G F+L TG+LT + DRE
Sbjct: 474 IELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE 533
Query: 692 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEAN 745
+R+I +TA D G P S A V + V D NDN+P F ++ NL
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKY 588
Query: 746 AFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVAT 804
+ VG + TD DAG N V S+ N N+ F + +G I + V +RE + Y V AT
Sbjct: 589 STVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 805 DGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDL 860
DG PR ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDT 707
Query: 861 GAN--VSYRIRSPEVKHFFALHPFTGELSL 888
G N + Y I S K F + P TG ++L
Sbjct: 708 GMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 6e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 507 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 565
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 566 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 620
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 621 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 674
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 675 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 733
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 734 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 785
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 786 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 845
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 846 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 905
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 906 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 964
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 965 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1024
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1025 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1075
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVI 1101
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 142 bits (357), Expect = 4e-33
Identities = 171/658 (25%), Positives = 288/658 (43%), Gaps = 73/658 (11%)
Query: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 197 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 255
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 256 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 316 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 376 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 431
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 432 VALDKDIEDVPPSGVPTKDPELHLFLND-YTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
DKD DV + + E+ L Y + + + + + +D E + ++
Sbjct: 387 TVSDKD-TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL---------LDYEGTKEFS 436
Query: 491 FSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
F I A D + S + +V +++ D NDN P F + ++ V + R G + ++A D
Sbjct: 437 FKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDE 496
Query: 549 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 608
D G N +I Y++ A F +++ TG++T + + + TV A DN P
Sbjct: 497 DSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQ 553
Query: 609 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIE 665
S V + VL N+ S P+F + +SE + + + + TD E ++T +I
Sbjct: 554 SQAAVIVTVLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL 612
Query: 666 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 724
N + F L +G++ + DRE Y + A+D G+P +STA V I V DVND
Sbjct: 613 NDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670
Query: 725 NAP-VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 777
N+P V P + +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 671 NSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 95.9 bits (237), Expect = 3e-19
Identities = 85/317 (26%), Positives = 136/317 (42%), Gaps = 45/317 (14%)
Query: 283 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 341
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 342 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVI 506
+ + L+ Y+ V + DRE+Q +YTF + A DG Q S
Sbjct: 612 LNDNDNFVLDPYSGVIKSNVS-----------FDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 507 VNIQVMDANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 563
V I VMD NDN+P P + V PG V ++ AVD D G N E+ Y I+ G
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 564 -AQGDFIINKTTGLITI 579
+G F I+ TG IT+
Sbjct: 721 NNKGLFRIDPVTGNITL 737
Score = 47.8 bits (112), Expect = 1e-04
Identities = 63/245 (25%), Positives = 101/245 (41%), Gaps = 44/245 (17%)
Query: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE---PVNRDFHQKFDLVIKAEQ 374
+ + Y+I+ G + F + P T ++L E P + H+ LV+
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEEKPAPTDVGLHR---LVVNI-S 756
Query: 375 DNGHP 379
D G+P
Sbjct: 757 DLGYP 761
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 196 bits (497), Expect = 2e-49
Identities = 224/804 (27%), Positives = 348/804 (43%), Gaps = 64/804 (7%)
Query: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 304
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 305 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 364
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 365 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDR 483
L + A+D D V +GV ++ EL N + V + L + + +DR
Sbjct: 192 LPA-----AVDPD---VGINGV--QNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 241
Query: 484 EEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
EE+ TY + DG Q S I+ + V D NDN P F E +V + + G SV
Sbjct: 242 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301
Query: 542 QLTAVDADEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 597
QL A DAD G N +I + LV A+ F +N TTGLITI ++ + L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361
Query: 598 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQA 652
+D R V + V N+ P + + + + +SE + + + +
Sbjct: 362 SDGGLMPAR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 653 TDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 708
TD++ D +T ++ P R+ + +L LD EST Y + + A+D G+P
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP 477
Query: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYS 767
+A + I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y
Sbjct: 478 LNQSAMLFIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYL 536
Query: 768 LG-NFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
LG + F + + T VK L+RE D Y ++A D V P S +T+ + ++D +
Sbjct: 537 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQN 596
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
DNSPVFT++ Y V ENLP T+ I D D G N + + + F + TG
Sbjct: 597 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGV 656
Query: 886 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK- 944
+ S D E ++ S TF V+A D A VT+ V D+ND PVF Y
Sbjct: 657 IRPNISFDRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 712
Query: 945 --GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 1002
+V P GT + V A D D G+ A VRY + +F +++++G +
Sbjct: 713 SYELVLPSTNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITL 767
Query: 1003 RVNLNEEPTTIFKLVVVAFDDGEP 1026
+ + +++V A D G+P
Sbjct: 768 MEKCDVTDLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 564
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 565 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 671
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 730
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 731 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 776
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 895
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 953
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1066
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1067 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1124
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1125 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 636 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 689
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 690 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 743 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 793
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 853
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 854 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 962
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 963 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 1021 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1075
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1196 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1255
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1256 NQLDMQVIVSNVPP 1269
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 167 bits (424), Expect = 6e-41
Identities = 193/777 (24%), Positives = 330/777 (42%), Gaps = 91/777 (11%)
Query: 103 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 156
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 157 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 215
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 395
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 396 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT--KDPEL 453
P + YI+ PV T+ S N+ +I + +D +G T D E+
Sbjct: 383 NVPSIDI----RYIVN--PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 436
Query: 454 HLFLND-YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQ 510
L +++ F + +D E + Y + A D + ++ ++ I+
Sbjct: 437 PFRLRPVFSNQFLLENAAY---------LDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 487
Query: 511 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570
V D NDN P F + V + + PG +++++A DAD G N EI Y + A +F +
Sbjct: 488 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSL 547
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 630
++ TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F
Sbjct: 548 DRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTH 604
Query: 631 LMYSLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALD 689
Y + E + R G V L GD+ + D F + TG++ + D
Sbjct: 605 NEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFD 664
Query: 690 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEAN 745
RE + Y + A D GR +S+A V I V DVNDN PVF PY L +
Sbjct: 665 REKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
V QV A D D G+N +V YS+ GN +LF I G+I K +
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------ 772
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
TD +H + +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 773 VTDLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 196 bits (497), Expect = 2e-49
Identities = 224/804 (27%), Positives = 348/804 (43%), Gaps = 64/804 (7%)
Query: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 304
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 305 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 364
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 365 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDR 483
L + A+D D V +GV ++ EL N + V + L + + +DR
Sbjct: 192 LPA-----AVDPD---VGINGV--QNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 241
Query: 484 EEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
EE+ TY + DG Q S I+ + V D NDN P F E +V + + G SV
Sbjct: 242 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301
Query: 542 QLTAVDADEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 597
QL A DAD G N +I + LV A+ F +N TTGLITI ++ + L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361
Query: 598 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQA 652
+D R V + V N+ P + + + + +SE + + + +
Sbjct: 362 SDGGLMPAR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 653 TDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 708
TD++ D +T ++ P R+ + +L LD EST Y + + A+D G+P
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP 477
Query: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYS 767
+A + I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y
Sbjct: 478 LNQSAMLFIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYL 536
Query: 768 LG-NFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
LG + F + + T VK L+RE D Y ++A D V P S +T+ + ++D +
Sbjct: 537 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQN 596
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
DNSPVFT++ Y V ENLP T+ I D D G N + + + F + TG
Sbjct: 597 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGV 656
Query: 886 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK- 944
+ S D E ++ S TF V+A D A VT+ V D+ND PVF Y
Sbjct: 657 IRPNISFDRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 712
Query: 945 --GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 1002
+V P GT + V A D D G+ A VRY + +F +++++G +
Sbjct: 713 SYELVLPSTNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITL 767
Query: 1003 RVNLNEEPTTIFKLVVVAFDDGEP 1026
+ + +++V A D G+P
Sbjct: 768 MEKCDVTDLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 564
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 565 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 671
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 730
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 731 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 776
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 895
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 953
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1066
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1067 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1124
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1125 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 636 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 689
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 690 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 743 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 793
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 853
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 854 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 962
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 963 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 1021 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1075
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1196 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1255
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1256 NQLDMQVIVSNVPP 1269
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 167 bits (424), Expect = 6e-41
Identities = 193/777 (24%), Positives = 330/777 (42%), Gaps = 91/777 (11%)
Query: 103 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 156
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 157 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 215
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 395
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 396 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT--KDPEL 453
P + YI+ PV T+ S N+ +I + +D +G T D E+
Sbjct: 383 NVPSIDI----RYIVN--PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 436
Query: 454 HLFLND-YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQ 510
L +++ F + +D E + Y + A D + ++ ++ I+
Sbjct: 437 PFRLRPVFSNQFLLENAAY---------LDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 487
Query: 511 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570
V D NDN P F + V + + PG +++++A DAD G N EI Y + A +F +
Sbjct: 488 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSL 547
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 630
++ TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F
Sbjct: 548 DRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTH 604
Query: 631 LMYSLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALD 689
Y + E + R G V L GD+ + D F + TG++ + D
Sbjct: 605 NEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFD 664
Query: 690 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEAN 745
RE + Y + A D GR +S+A V I V DVNDN PVF PY L +
Sbjct: 665 REKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
V QV A D D G+N +V YS+ GN +LF I G+I K +
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------ 772
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
TD +H + +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 773 VTDLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 196 bits (497), Expect = 2e-49
Identities = 224/804 (27%), Positives = 348/804 (43%), Gaps = 64/804 (7%)
Query: 250 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 304
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 14 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 73
Query: 305 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 364
+ Q + + D P L+ ED F R L + RD H
Sbjct: 74 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 127
Query: 365 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 424
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 128 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 180
Query: 425 LTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDR 483
L + A+D D V +GV ++ EL N + V + L + + +DR
Sbjct: 181 LPA-----AVDPD---VGINGV--QNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 230
Query: 484 EEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
EE+ TY + DG Q S I+ + V D NDN P F E +V + + G SV
Sbjct: 231 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 290
Query: 542 QLTAVDADEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 597
QL A DAD G N +I + LV A+ F +N TTGLITI ++ + L V A
Sbjct: 291 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 350
Query: 598 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQA 652
+D R V + V N+ P + + + + +SE + + + +
Sbjct: 351 SDGGLMPAR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406
Query: 653 TDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 708
TD++ D +T ++ P R+ + +L LD EST Y + + A+D G+P
Sbjct: 407 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPP 466
Query: 709 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYS 767
+A + I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y
Sbjct: 467 LNQSAMLFIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYL 525
Query: 768 LG-NFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 825
LG + F + + T VK L+RE D Y ++A D V P S +T+ + ++D +
Sbjct: 526 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQN 585
Query: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 885
DNSPVFT++ Y V ENLP T+ I D D G N + + + F + TG
Sbjct: 586 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGV 645
Query: 886 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK- 944
+ S D E ++ S TF V+A D A VT+ V D+ND PVF Y
Sbjct: 646 IRPNISFDRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNY 701
Query: 945 --GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 1002
+V P GT + V A D D G+ A VRY + +F +++++G +
Sbjct: 702 SYELVLPSTNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITL 756
Query: 1003 RVNLNEEPTTIFKLVVVAFDDGEP 1026
+ + +++V A D G+P
Sbjct: 757 MEKCDVTDLGLHRVLVKANDLGQP 780
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 564
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 144 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 202
Query: 565 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 260
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 671
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 261 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 730
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 378
Query: 731 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 776
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 379 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 439 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 895
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 953
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 553 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 606
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 607 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 659
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1066
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 660 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719
Query: 1067 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1124
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 720 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 779
Query: 1125 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
VV+ NL V A + E+ ++ PV
Sbjct: 780 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 636 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 689
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 54 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 113
Query: 690 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 114 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 172
Query: 743 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 793
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 173 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232
Query: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 853
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 233 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 292
Query: 854 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 293 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 348
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 962
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 349 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406
Query: 963 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 407 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 459
Query: 1021 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1075
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 460 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 518
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 519 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 570
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 571 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630
Query: 1196 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1255
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 631 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 1256 NQLDMQVIVSNVPP 1269
+ D + + VPP
Sbjct: 686 DVNDNKPVFI-VPP 698
Score = 167 bits (424), Expect = 6e-41
Identities = 193/777 (24%), Positives = 330/777 (42%), Gaps = 91/777 (11%)
Query: 103 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 156
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 107 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 161
Query: 157 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 215
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 162 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 218
Query: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 219 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 270
Query: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
+ + +IPE N + T Q D +I + I +S
Sbjct: 271 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 313
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 395
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 314 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 371
Query: 396 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT--KDPEL 453
P + YI+ PV T+ S N+ +I + +D +G T D E+
Sbjct: 372 NVPSIDI----RYIVN--PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 425
Query: 454 HLFLND-YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQ 510
L +++ F + +D E + Y + A D + ++ ++ I+
Sbjct: 426 PFRLRPVFSNQFLLENAAY---------LDYESTKEYAIKLLAADAGKPPLNQSAMLFIK 476
Query: 511 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570
V D NDN P F + V + + PG +++++A DAD G N EI Y + A +F +
Sbjct: 477 VKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSL 536
Query: 571 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 630
++ TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F
Sbjct: 537 DRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTH 593
Query: 631 LMYSLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALD 689
Y + E + R G V L GD+ + D F + TG++ + D
Sbjct: 594 NEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFD 653
Query: 690 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEAN 745
RE + Y + A D GR +S+A V I V DVNDN PVF PY L +
Sbjct: 654 REKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 713
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
V QV A D D G+N +V YS+ GN +LF I G+I K +
Sbjct: 714 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------ 761
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
TD +H + +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 762 VTDLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 812
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 192 bits (488), Expect = 2e-48
Identities = 221/797 (27%), Positives = 348/797 (43%), Gaps = 66/797 (8%)
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 312
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 313 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 372
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
D L L I D N+ +P F I S P + I+ L +
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPA----- 162
Query: 433 ALDKDIEDVPPSGVPTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTF 491
A+D D V +GV ++ EL N + V + L + + +DREE+ TY
Sbjct: 163 AVDPD---VGINGV--QNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVM 217
Query: 492 SITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DAD
Sbjct: 218 KVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDAD 277
Query: 550 EGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 605
G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 278 IGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPA 337
Query: 606 RRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS- 659
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 338 R----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHN 393
Query: 660 --ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 716
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 394 GRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 717 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNL 774
I V D NDNAPVF +S+ E + + +V A D D+G N +++Y LG +
Sbjct: 454 IKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE 512
Query: 775 FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT+
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTH 572
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 893
+ Y V ENLP T+ I D D G N + + + F + TG + S D
Sbjct: 573 NEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFD 632
Query: 894 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAP 949
E ++ S TF V+A D A VT+ V D+ND PVF S Y+ +V P
Sbjct: 633 RE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLP 687
Query: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 688 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 742
Query: 1010 PTTIFKLVVVAFDDGEP 1026
+ +++V A D G+P
Sbjct: 743 DLGLHRVLVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 564
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 565 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 671
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 730
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 731 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 776
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 895
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 953
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1066
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1067 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1124
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1125 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 5e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 636 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 689
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 690 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 743 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 793
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 853
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 854 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 962
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 963 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 1021 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1075
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1196 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1255
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1256 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1310
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1311 SLEDYT-------KCDLT 1321
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 162 bits (411), Expect = 2e-39
Identities = 195/777 (25%), Positives = 329/777 (42%), Gaps = 91/777 (11%)
Query: 103 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 156
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 157 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 215
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 395
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 396 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT--KDPEL 453
P + YI+ PV T+ S N+ +I + +D +G T D E+
Sbjct: 351 NVPSIDI----RYIVN--PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404
Query: 454 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 511
L S + +T YL D E + Y + A D + ++ ++ I+V
Sbjct: 405 PFRLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 456
Query: 512 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIIN 571
D NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD 516
Query: 572 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 631
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHN 573
Query: 632 MYSLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDR 690
Y+ + E + R G V L GD+ + D F + TG++ + DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 691 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEAN 745
E + Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPG 692
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
V QV A D D G+N +V YS+ GN +LF I G+I K +
Sbjct: 693 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------ 740
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
TD +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 741 VTDLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 192 bits (488), Expect = 2e-48
Identities = 221/797 (27%), Positives = 348/797 (43%), Gaps = 66/797 (8%)
Query: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 312
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 313 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 372
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 373 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 432
D L L I D N+ +P F I S P + I+ L +
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPA----- 162
Query: 433 ALDKDIEDVPPSGVPTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTF 491
A+D D V +GV ++ EL N + V + L + + +DREE+ TY
Sbjct: 163 AVDPD---VGINGV--QNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVM 217
Query: 492 SITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DAD
Sbjct: 218 KVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDAD 277
Query: 550 EGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 605
G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 278 IGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPA 337
Query: 606 RRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS- 659
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 338 R----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHN 393
Query: 660 --ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 716
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 394 GRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 717 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNL 774
I V D NDNAPVF +S+ E + + +V A D D+G N +++Y LG +
Sbjct: 454 IKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE 512
Query: 775 FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT+
Sbjct: 513 FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTH 572
Query: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 893
+ Y V ENLP T+ I D D G N + + + F + TG + S D
Sbjct: 573 NEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFD 632
Query: 894 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAP 949
E ++ S TF V+A D A VT+ V D+ND PVF S Y+ +V P
Sbjct: 633 RE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLP 687
Query: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 688 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 742
Query: 1010 PTTIFKLVVVAFDDGEP 1026
+ +++V A D G+P
Sbjct: 743 DLGLHRVLVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 564
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 565 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 617
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 618 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 671
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 672 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 730
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 731 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 776
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 777 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 837 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 895
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 953
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 1014 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1066
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1067 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1124
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1125 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1155
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 5e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 636 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 689
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 690 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 743 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 793
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 794 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 853
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 854 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 909 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 962
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 963 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 1021 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1075
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1076 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1196 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1255
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1256 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1310
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1311 SLEDYT-------KCDLT 1321
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 162 bits (411), Expect = 2e-39
Identities = 195/777 (25%), Positives = 329/777 (42%), Gaps = 91/777 (11%)
Query: 103 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 156
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 157 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 215
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 395
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 396 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT--KDPEL 453
P + YI+ PV T+ S N+ +I + +D +G T D E+
Sbjct: 351 NVPSIDI----RYIVN--PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404
Query: 454 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQV 511
L S + +T YL D E + Y + A D + ++ ++ I+V
Sbjct: 405 PFRLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 456
Query: 512 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIIN 571
D NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 457 KDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD 516
Query: 572 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 631
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F
Sbjct: 517 CRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHN 573
Query: 632 MYSLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDR 690
Y+ + E + R G V L GD+ + D F + TG++ + DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 691 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEAN 745
E + Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPG 692
Query: 746 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVV 802
V QV A D D G+N +V YS+ GN +LF I G+I K +
Sbjct: 693 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------ 740
Query: 803 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 859
TD +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 741 VTDLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,766,656
Number of Sequences: 37866
Number of extensions: 3959309
Number of successful extensions: 89244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1121
Number of HSP's successfully gapped in prelim test: 1525
Number of HSP's that attempted gapping in prelim test: 29172
Number of HSP's gapped (non-prelim): 26097
length of query: 1790
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1673
effective length of database: 13,817,196
effective search space: 23116168908
effective search space used: 23116168908
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.