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Search of human proteins with 218505785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo
sapiens]
(1935 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 3874 0.0
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 3863 0.0
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 3861 0.0
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 3859 0.0
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 3849 0.0
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 3838 0.0
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 3747 0.0
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 2845 0.0
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 2845 0.0
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 2843 0.0
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 2836 0.0
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 2616 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 343 1e-93
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 324 6e-88
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 314 5e-85
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 293 1e-78
gi|16933557 dachsous 1 precursor [Homo sapiens] 291 3e-78
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 290 7e-78
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 281 3e-75
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 278 3e-74
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 268 4e-71
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 266 1e-70
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 221 7e-57
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 206 1e-52
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 206 1e-52
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 198 4e-50
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 198 4e-50
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 198 4e-50
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 195 4e-49
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 195 4e-49
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 3874 bits (10046), Expect = 0.0
Identities = 1935/1935 (100%), Positives = 1935/1935 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD 60
Query: 61 YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND 120
YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND
Sbjct: 61 YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND 120
Query: 121 NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND 180
NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND
Sbjct: 121 NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND 180
Query: 181 TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG 240
TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG
Sbjct: 181 TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG 240
Query: 241 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI 300
PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI
Sbjct: 241 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI 300
Query: 301 LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 360
LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH
Sbjct: 301 LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 360
Query: 361 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 420
IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH
Sbjct: 361 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 420
Query: 421 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA 480
LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA
Sbjct: 421 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA 480
Query: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 540
NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT
Sbjct: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 540
Query: 541 GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 600
GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS
Sbjct: 541 GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 600
Query: 601 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD
Sbjct: 601 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
Query: 661 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 720
RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT
Sbjct: 661 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 720
Query: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST
Sbjct: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Query: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK 840
LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK
Sbjct: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK 840
Query: 841 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 900
HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY
Sbjct: 841 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 900
Query: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP 1020
EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP
Sbjct: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP 1020
Query: 1021 PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS
Sbjct: 1021 PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
Query: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1200
VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV
Sbjct: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1200
Query: 1201 IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA 1260
IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA
Sbjct: 1201 IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA 1260
Query: 1261 KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ 1320
KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ
Sbjct: 1261 KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ 1320
Query: 1321 PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQF 1380
PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQF
Sbjct: 1321 PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQF 1380
Query: 1381 KVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL 1440
KVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL
Sbjct: 1381 KVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL 1440
Query: 1441 YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED 1500
YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED
Sbjct: 1441 YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED 1500
Query: 1501 DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL 1560
DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL
Sbjct: 1501 DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL 1560
Query: 1561 PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR 1620
PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR
Sbjct: 1561 PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR 1620
Query: 1621 QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL 1680
QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL
Sbjct: 1621 QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL 1680
Query: 1681 SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP 1740
SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP
Sbjct: 1681 SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP 1740
Query: 1741 APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP 1800
APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP
Sbjct: 1741 APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP 1800
Query: 1801 PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK 1860
PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK
Sbjct: 1801 PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK 1860
Query: 1861 GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI 1920
GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI
Sbjct: 1861 GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI 1920
Query: 1921 VEGTEKQSHSQSTSL 1935
VEGTEKQSHSQSTSL
Sbjct: 1921 VEGTEKQSHSQSTSL 1935
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 3863 bits (10017), Expect = 0.0
Identities = 1932/1935 (99%), Positives = 1932/1935 (99%), Gaps = 3/1935 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDPTIELSLKDNVD 60
Query: 61 YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND 120
YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND
Sbjct: 61 YWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRND 120
Query: 121 NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND 180
NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND
Sbjct: 121 NSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSND 180
Query: 181 TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG 240
TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG
Sbjct: 181 TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLG 240
Query: 241 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI 300
PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI
Sbjct: 241 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI 300
Query: 301 LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 360
LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH
Sbjct: 301 LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 360
Query: 361 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 420
IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH
Sbjct: 361 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 420
Query: 421 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA 480
LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA
Sbjct: 421 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDA 480
Query: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 540
NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT
Sbjct: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 540
Query: 541 GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 600
GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS
Sbjct: 541 GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 600
Query: 601 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD
Sbjct: 601 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
Query: 661 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 720
RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT
Sbjct: 661 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 720
Query: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST
Sbjct: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Query: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK 840
LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK
Sbjct: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK 840
Query: 841 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 900
HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY
Sbjct: 841 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 900
Query: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP 1020
EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP
Sbjct: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRP 1020
Query: 1021 PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS
Sbjct: 1021 PPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
Query: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1200
VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV
Sbjct: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1200
Query: 1201 IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA 1260
IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA
Sbjct: 1201 IATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGA 1260
Query: 1261 KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ 1320
KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ
Sbjct: 1261 KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ 1320
Query: 1321 PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQF 1380
PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQ
Sbjct: 1321 PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQ- 1379
Query: 1381 KVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL 1440
RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL
Sbjct: 1380 --RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLL 1437
Query: 1441 YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED 1500
YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED
Sbjct: 1438 YHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDED 1497
Query: 1501 DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL 1560
DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL
Sbjct: 1498 DLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSL 1557
Query: 1561 PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR 1620
PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR
Sbjct: 1558 PRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIR 1617
Query: 1621 QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL 1680
QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL
Sbjct: 1618 QGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLEL 1677
Query: 1681 SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP 1740
SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP
Sbjct: 1678 SPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPP 1737
Query: 1741 APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP 1800
APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP
Sbjct: 1738 APAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPP 1797
Query: 1801 PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK 1860
PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK
Sbjct: 1798 PPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPK 1857
Query: 1861 GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI 1920
GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI
Sbjct: 1858 GILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNI 1917
Query: 1921 VEGTEKQSHSQSTSL 1935
VEGTEKQSHSQSTSL
Sbjct: 1918 VEGTEKQSHSQSTSL 1932
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 3861 bits (10013), Expect = 0.0
Identities = 1935/1957 (98%), Positives = 1935/1957 (98%), Gaps = 22/1957 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1441 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1500
Query: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1501 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1560
Query: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1561 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1620
Query: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1621 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1680
Query: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1681 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1740
Query: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1741 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1800
Query: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1801 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1860
Query: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1861 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1920
Query: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1957
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 3859 bits (10008), Expect = 0.0
Identities = 1935/1962 (98%), Positives = 1935/1962 (98%), Gaps = 27/1962 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD---------------------------GTI 33
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 34 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 93
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 213
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 214 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 333
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 334 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 393
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 394 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 454 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 514 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 573
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 694 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 753
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 754 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 813
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 814 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 873
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 874 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 933
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 934 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 993
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 994 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1053
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1173
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1174 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1233
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1234 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1293
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1294 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1353
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1354 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1413
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1414 PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1473
PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1500
Query: 1474 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1533
KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS
Sbjct: 1501 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1560
Query: 1534 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1593
PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG
Sbjct: 1561 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1620
Query: 1594 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1653
ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST
Sbjct: 1621 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1680
Query: 1654 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1713
LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN
Sbjct: 1681 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1740
Query: 1714 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1773
FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP
Sbjct: 1741 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1800
Query: 1774 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1833
TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM
Sbjct: 1801 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1860
Query: 1834 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1893
PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS
Sbjct: 1861 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1920
Query: 1894 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1962
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 3849 bits (9982), Expect = 0.0
Identities = 1932/1957 (98%), Positives = 1933/1957 (98%), Gaps = 24/1957 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1441 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1498
Query: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1499 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1558
Query: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1559 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1618
Query: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1619 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1678
Query: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1679 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1738
Query: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1739 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1798
Query: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1799 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1858
Query: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1859 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1918
Query: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1919 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1955
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 3838 bits (9953), Expect = 0.0
Identities = 1929/1957 (98%), Positives = 1930/1957 (98%), Gaps = 27/1957 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1437
Query: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1438 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1495
Query: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1496 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1555
Query: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1556 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1615
Query: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1616 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1675
Query: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1676 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1735
Query: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1736 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1795
Query: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1796 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1855
Query: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1856 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1915
Query: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1916 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1952
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 3747 bits (9717), Expect = 0.0
Identities = 1892/1957 (96%), Positives = 1893/1957 (96%), Gaps = 64/1957 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
Query: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1401 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1458
Query: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1459 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1518
Query: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1519 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1578
Query: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1579 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1638
Query: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1639 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1698
Query: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1699 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1758
Query: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1759 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1818
Query: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1819 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1878
Query: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1879 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 2845 bits (7374), Expect = 0.0
Identities = 1435/1457 (98%), Positives = 1435/1457 (98%), Gaps = 22/1457 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1419 PPPGAHLYEELGDSSMH 1435
PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 2845 bits (7374), Expect = 0.0
Identities = 1435/1457 (98%), Positives = 1435/1457 (98%), Gaps = 22/1457 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1419 PPPGAHLYEELGDSSMH 1435
PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 2843 bits (7369), Expect = 0.0
Identities = 1435/1462 (98%), Positives = 1435/1462 (98%), Gaps = 27/1462 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD---------------------------GTI 33
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 34 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 93
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 213
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 214 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 333
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 334 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 393
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 394 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 454 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 514 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 573
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 694 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 753
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 754 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 813
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 814 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 873
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 874 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 933
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 934 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 993
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 994 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1053
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1173
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1174 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1233
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1234 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1293
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1294 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1353
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1354 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1413
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1414 PPPPPPPPGAHLYEELGDSSMH 1435
PPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMH 1462
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 2836 bits (7351), Expect = 0.0
Identities = 1435/1469 (97%), Positives = 1435/1469 (97%), Gaps = 34/1469 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD---------------------------GTI 33
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 34 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 93
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 213
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 214 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 333
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 334 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 393
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 394 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 446
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
Query: 447 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 507 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 567 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 626
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 686
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 687 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 746
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
Query: 807 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 866
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 867 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 926
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 927 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 987 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1046
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
Query: 1047 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Query: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
Query: 1167 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1226
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Query: 1227 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1286
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
Query: 1287 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1346
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
Query: 1347 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1406
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
Query: 1407 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1435
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 2616 bits (6781), Expect = 0.0
Identities = 1373/1684 (81%), Positives = 1447/1684 (85%), Gaps = 78/1684 (4%)
Query: 322 TAELSLLEPVNRDFHQKFDLVIKAE---QDNGHPLPAFAGLHIEILDENNQSPYFT---- 374
T + L + +N + ++ ++I+A Q+ L +++LD ++ P F
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 375 MPSYQG---YILESAPVGATISDSLN---LTSPLRIVALDKDIEDTKDPELHLFL----- 423
+P+ + ++A + LN +T P++ + D++I+ D L+
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 424 -NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDA 480
DY F + T L+LL+PV+R+ Q + I A P ++I+++D
Sbjct: 331 PEDYPRFFHMHPR--TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 388
Query: 481 NDNTPTFPEISYDVYVYTDMRPGDSV---------IQLTAVDAD-EGSNGEITYEILVGA 530
N+ +P F SY Y+ G ++ +++ A+D D E + + L
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
Query: 531 QGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 588
F + +T T +T+ V+ +TY ++ A D +E V I+V+ N+
Sbjct: 449 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDAND 504
Query: 589 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 645
+P FP++ Y + + MR G ++ L A D + S ITY I G Q F +++TT
Sbjct: 505 NTPT-FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT 562
Query: 646 G----------------------------------ILTLGKALDRESTDRYILIITASDG 671
G ILTLGKALDRESTDRYILIITASDG
Sbjct: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG 622
Query: 672 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 731
RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH
Sbjct: 623 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 682
Query: 732 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID
Sbjct: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Query: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 851
DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE
Sbjct: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
Query: 852 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 911
LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG
Sbjct: 803 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 862
Query: 912 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971
MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN
Sbjct: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
Query: 972 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1031
LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT
Sbjct: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 982
Query: 1032 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1091
MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE
Sbjct: 983 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1042
Query: 1092 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT
Sbjct: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
Query: 1152 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS
Sbjct: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
Query: 1212 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1271
GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR
Sbjct: 1163 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1222
Query: 1272 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1331
HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE
Sbjct: 1223 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1282
Query: 1332 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1391
IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA
Sbjct: 1283 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1342
Query: 1392 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNS 1451
RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNS
Sbjct: 1343 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNS 1402
Query: 1452 VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE 1511
VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE
Sbjct: 1403 VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE 1462
Query: 1512 NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR 1571
NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR
Sbjct: 1463 NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR 1522
Query: 1572 PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE 1631
PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE
Sbjct: 1523 PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE 1582
Query: 1632 QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS 1691
QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS
Sbjct: 1583 QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS 1642
Query: 1692 LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI 1751
LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI
Sbjct: 1643 LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI 1702
Query: 1752 SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP 1811
SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP
Sbjct: 1703 SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP 1762
Query: 1812 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE 1871
SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE
Sbjct: 1763 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE 1822
Query: 1872 LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ 1931
LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ
Sbjct: 1823 LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ 1882
Query: 1932 STSL 1935
STSL
Sbjct: 1883 STSL 1886
Score = 1206 bits (3120), Expect = 0.0
Identities = 704/1134 (62%), Positives = 782/1134 (68%), Gaps = 109/1134 (9%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI-- 576
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 577 -----------------------------CTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 607
TV I V N+ +P P L +L + E
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE- 659
Query: 608 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 664
A + ++ATD + + Y++ G+ +F ++ I T K L+RE D Y L
Sbjct: 660 EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYEL 716
Query: 665 IITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 723
++ A+DG ST T+ I V D++DN+PVF L A + Q++A D D
Sbjct: 717 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776
Query: 724 AGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE----LVVVATD--GAVHP 776
G N + F + G + L+ E E +V A D G + P
Sbjct: 777 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
Query: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD----LGANVSY 832
+T+T+ +K D++D PVF+ Y +V + GT I + A+D D + V Y
Sbjct: 837 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
Query: 833 R---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 889
R ++ P F + +G + +L+ E +V AFD + AT
Sbjct: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLVVVAFDDGEPVMSSSAT 950
Query: 890 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 949
V ++V + P + V+ A KGT + + A A + S V +D
Sbjct: 951 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AINQSIVYSIVSGNEEDT- 1008
Query: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM------SSSATVKIL 1003
F + +G + L+ E T + L V A D E V+ S S T K+
Sbjct: 1009 -------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVY 1060
Query: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1057
+ EI Q+E PPV + K + GV A + S++ V ++DT
Sbjct: 1061 I----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR--VKATDKDT 1102
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 343 bits (879), Expect = 1e-93
Identities = 319/1192 (26%), Positives = 533/1192 (44%), Gaps = 135/1192 (11%)
Query: 77 TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
T +LDR+ ++ +V V I K EV I ++D NDN P F + TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 194
E G+ I A D D+G N + Y I DD D +G+++
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDPE------SGDLIA 1798
Query: 195 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 254
+RL+ E +++Y ++++A+D Q+ + R + + V D +D P F
Sbjct: 1799 TRRLDRERRSKYSLLVRADDGLQSSDMR------INITVSDVNDHTPKF----------- 1841
Query: 255 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
RP+ Y IPE P L I+ A D D + I Y + +D
Sbjct: 1842 SRPV-YSFDIPEDTIPGSLVAAIL-----ATDDDSGVNGE-----ITYIV---NEDDEDG 1887
Query: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374
F ++P T +L ++ + Q + L ++AE G ++ ILD N+ P F+
Sbjct: 1888 IFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTI--RVYFNILDVNDNPPIFS 1945
Query: 375 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL--NDYTSVFTV 432
+ SY ++E+ PVG+T+ N+T D +D + +L + D FTV
Sbjct: 1946 LNSYSTSLMENLPVGSTVL-VFNVT----------DADDGINSQLTYSIASGDSLGQFTV 1994
Query: 433 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE-----SEPVIVNIQVMDANDNTPTF 487
+ G+ L +L+ +DRE Q Y + D Q + V+I ++D NDN PTF
Sbjct: 1995 DKNGV---LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051
Query: 488 --PEISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 544
P+++Y + P D+V+ + A D D G N I Y +L F I G +
Sbjct: 2052 LSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107
Query: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
+ ++ Y LTV A D P+ ++ V + + NN P F Q +Y +EI+
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN---PIFAQALYKVEIN 2164
Query: 605 EAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDR 661
E G ++ + A D + + Y I NG+ + F + TG +T+ K LDRE T
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPT 2224
Query: 662 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD--PY---LPRNLSVVEEEANAFVG 715
Y L + A+D G T T+TV+IV+ D+ND PVF+ PY +P NL + +
Sbjct: 2225 YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT----IL 2280
Query: 716 QVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 773
QV A D D G N ++ Y L GN +N F ++++G + L+RE ++ + L++ ATD
Sbjct: 2281 QVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSG 2340
Query: 774 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 833
T T+ + V D++DN P F + Y + E+ P GT +L + A D D N R
Sbjct: 2341 SPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR 2400
Query: 834 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTV 892
I + F ++P TG++ LD E + + T +V D P +T V V
Sbjct: 2401 IIGGNSQ--FTINPSTGQIITSALLDRET----KDNYTLVVVCSDAGSPEPLSSSTSVLV 2454
Query: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
V D+ND PP F Y + + G+ + V DAD P S + Y +
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLSGRN--- 2509
Query: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPR 1012
+ F ++ G ++ LN F + V D G + S TV + ++ + P+
Sbjct: 2510 -SEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKADFPK 2566
Query: 1013 FTQEEY-----RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1067
+E PVS L T + ++ + + Y I SGN +TF I+ +TG +
Sbjct: 2567 VRAKEQTFMFPENQPVSSLVTT-----ITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQV 2621
Query: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127
++ PLD+E YV+ ++A + P S+ K+ I + D N++ P+F++ +
Sbjct: 2622 SISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPF 2674
Query: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187
I + E+ +L V A DKD+G + Y ++ + + F + TG I++
Sbjct: 2675 ISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNM---ENSFSINHATGEIRSVRP 2730
Query: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD-----MQVIVSNVP 1234
+ S++ + ++D S V+++++++ D Q+ ++VP
Sbjct: 2731 LDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Score = 331 bits (849), Expect = 4e-90
Identities = 298/1109 (26%), Positives = 500/1109 (45%), Gaps = 88/1109 (7%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
I V D ND+ P F + Y ++E P G+ + +G S ATD D G N + Y I
Sbjct: 463 IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV-SGIS----ATDGDSGLNANLRYSIVSG 517
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
+ + L+ TG+ L+ E ++ + I A D+ + + + L V
Sbjct: 518 NGLGWFHISEHSGLVTTGS---SGGLDRELASQIVLNISARDQGVH---PKVSYAQLVVT 571
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
+LD +D P+F +P Y ++ E P ++ ++A D D
Sbjct: 572 LLDVNDEKPVF-----------SQPEGYDVSVVE-NAPTGTELLM----LRATDGDLG-- 613
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
D + +S+ E R F + P + LS + ++R+ + L++ A P
Sbjct: 614 ---DNGTVRFSLQEA--ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPP 668
Query: 353 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412
+ A +++ +LD N+ SP F Y +I E+ P G+ I+ + A D D+
Sbjct: 669 QSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---------VSATDPDLG 719
Query: 413 DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEP 470
+ + D + Q+G+ ++ +DREE+ Y I A DG +Q
Sbjct: 720 TNGTVKYSISAGDRSRFQVNAQSGV---ISTRMALDREEKTAYQLQIVATDGGNLQSPNQ 776
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
IV I V+D DN P F +++Y V+ ++ G V ++A D SN I+Y I G
Sbjct: 777 AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTGD 834
Query: 531 Q-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQ 589
Q G F IN+ TG +T A ++ Y L V A+ + +I + N
Sbjct: 835 QKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDL------ND 888
Query: 590 SPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTG 646
+ P F Q + S+ + E + G + +A D + + Y+++ +P+ +F ++E G
Sbjct: 889 NSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNG 947
Query: 647 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 706
++L LD + I I+ + G P +S+ + + V DVNDN+PVFD
Sbjct: 948 TISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSE 1007
Query: 707 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYE 764
E N+ +V+A+D D+G NG++ Y++ GN + F I +G +Y +L+RE++D Y
Sbjct: 1008 SEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYV 1067
Query: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824
L+VVA+D AV P +T+ + + + D++DN P+F ++ YT EE AG+ + ++ A D
Sbjct: 1068 LMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDK 1127
Query: 825 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
D G N R V+ F LH +GE++ D E+ + + F +P
Sbjct: 1128 DFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP 1187
Query: 885 PGI---ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPAS 939
+ ATV V +KD+ND P F K Y+ ++ A T + V A D D GL
Sbjct: 1188 QPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHY 1247
Query: 940 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 999
+ ++ Q F ++ SG+V L+ E T + LV+ A D G ++S+ T
Sbjct: 1248 SIIKGNEERQ-------FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCT 1300
Query: 1000 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1055
+ I +L + + V E G +V ++A + N + YSI N
Sbjct: 1301 LNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNH 1360
Query: 1056 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
TF I+ TG I++ LD+ET++ Y L + A + P +S+T V I ++D
Sbjct: 1361 GTFSISPNTGSIFLAKKLDFETQSLYKLNITA-------KDQGRPPRSSTMSVVIHVRDF 1413
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
N++PP F + E+ + TSV+ V A D D ++Y II + G F +
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPRGNH-FTI 1471
Query: 1176 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
+ G I T + F+ V A D
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKAND 1500
Score = 298 bits (764), Expect = 3e-80
Identities = 309/1151 (26%), Positives = 507/1151 (44%), Gaps = 143/1151 (12%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
EVR++VRD NDN+P F S T E + G + + ATD D G NG
Sbjct: 120 EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVIL-----DTATDSDIGSNGVDHRSY 174
Query: 170 QYNPDDPTSNDTFEIPLMLTG-----NIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 224
+ + +I L +G ++V + L+ E +Y ++++ D+ + +R
Sbjct: 175 RIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGE---PKRR 231
Query: 225 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 284
+ V V D +D P+F YQA +PE + ++ + +Q
Sbjct: 232 GYLQVNVTVQDINDNPPVF------------GSSHYQAGVPE-------DAVVGSSVLQV 272
Query: 285 IDQDRNIQPPSDRPGILYSIL-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
D + +D I Y + GTP F M P T +++ EP++ + +++ L +
Sbjct: 273 AAADADEGTNAD---IRYRLQDEGTP------FQMDPETGLITVREPLDFEARRQYSLTV 323
Query: 344 KAEQDNGHP-LPAFAGLHIEILDENNQSP-----YFTMPSYQGYILESAPVGATI----- 392
+A D G P L A I++LD N+ P YF S + E+A VG +
Sbjct: 324 QA-MDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 393 ----SDSLNLTSPLRIVALDK----DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 444
S + N ++I+ ++ +++ +K P L L + +
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL-------------------IKVA 423
Query: 445 QPVDREEQQTYTFSITAFDGV---------QESEPVIVNIQVMDANDNTPTFPEISYDVY 495
+DRE +Y +++ D S + I V D ND+ P F + Y V
Sbjct: 424 SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 496 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI--APGVEMI 552
+ + PG V ++A D D G N + Y I+ G G F I++ +GL+T + G++
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 553 VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 612
+ L + A D + S + + +L N++ P Y + + E G
Sbjct: 544 LASQIVLNISARDQG--VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTE 601
Query: 613 LLNLQATDRE-GD--SITYAIENGD-PQRVFNLSETTGILTLGKALDRESTDRYILIITA 668
LL L+ATD + GD ++ ++++ + +R F L +G L+ +LDRE Y L++ A
Sbjct: 602 LLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLA 661
Query: 669 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 727
+D G P +S A +N+ + D+NDN+PVF P E +++ V ATDPD G N
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 728 GQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAI 785
G V YS+ G+ + +G I T + L+RE + Y+L +VATDG + + I
Sbjct: 722 GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 845
VLD DN PVF+ Y+ +V EN+ G + + A +DL +N+SY I + + K FA+
Sbjct: 782 TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAI 841
Query: 846 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
+ TG+L+ + D+E + ++ GT+ G V + VKD+ND P F
Sbjct: 842 NQVTGQLTTANVI------DREEQSFYQLKVVASGGTV-TGDTMVNITVKDLNDNSPHFL 894
Query: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
+ I V + G I A+ DP V Y + P ++F + E +G
Sbjct: 895 QAIESVNVVENWQAGHSI--FQAKAVDPDEGVNGMVLYSLKQ----NPKNLFAINEKNGT 948
Query: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS 1024
+ L+ + +++ ++A D G P +SSS + + V + P F Q Y +S
Sbjct: 949 ISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE-VTLS 1006
Query: 1025 ELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
E + + A + N I Y+I GN D FGI G +Y+ LD E +
Sbjct: 1007 ESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDR 1065
Query: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
YVL VV ++ V S T V + ++D N++ P+F Y E+ R +
Sbjct: 1066 YVLM-------VVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSF 1118
Query: 1141 VLRVKATDKDTGNYSVMAYRL-IIPPIKEGKEGFVVETYTGLIKTAMLFHN---MRR--- 1193
V +V A DKD G + Y ++ P F + +G I F MRR
Sbjct: 1119 VGKVSAVDKDFGPNGEVRYSFEMVQP------DFELHAISGEITNTHQFDRESLMRRRGT 1172
Query: 1194 SYFKFQVIATD 1204
+ F F VIATD
Sbjct: 1173 AVFSFTVIATD 1183
Score = 288 bits (737), Expect = 4e-77
Identities = 286/1073 (26%), Positives = 476/1073 (44%), Gaps = 100/1073 (9%)
Query: 180 DTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDL 239
+TF+I LTG + + + L++E +Y V I+A D ++ L + VLD +D
Sbjct: 2610 NTFQID-QLTGQVSISQPLDFEKIQKYVVWIEARDGGF---PPFSSYEKLDITVLDVNDN 2665
Query: 240 GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG 299
P+F + + + I E +P + I+T + A+D+D D
Sbjct: 2666 APIF------------KEDPFISEILENLSPRK----ILT--VSAMDKDSGPNGQLD--- 2704
Query: 300 ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL 359
Y I+ G E+ F ++ T E+ + P++R+ + L IK+ +
Sbjct: 2705 --YEIVNGNMENS---FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKV 2759
Query: 360 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 419
I ILDEN+ +P F+ + ++ E++P+G T++ R+ D+DI
Sbjct: 2760 MINILDENDNAPRFSQ-IFSAHVPENSPLGYTVT---------RVTTSDEDIGINAISRY 2809
Query: 420 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 479
+ D + FT+ + T + + +P++RE+ Y ++A D + V I V D
Sbjct: 2810 SIM--DASLPFTINPS--TGDIVISRPLNREDTDRYRIRVSAHDSGW-TVSTDVTIFVTD 2864
Query: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INK 538
NDN P F SY + G V Q+ A D DEGSNG++ Y + +Q ++ IN
Sbjct: 2865 INDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY--FIKSQSEYFRINA 2922
Query: 539 TTGLI--------TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 590
TTG I G + ++ V ++D P+ + T+ I +N +
Sbjct: 2923 TTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV---DSNDN 2979
Query: 591 PPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTG 646
P+F + Y +++ ++VG L+ + A D + + Y I N + F L TG
Sbjct: 2980 APQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTG 3039
Query: 647 ILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 705
+++ +L + + + +TA D G P +S ATV+I VT+ N + P F
Sbjct: 3040 WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099
Query: 706 VEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDY 762
+ V V A D DA +NG + YS+ GN +F I S+ I T K L+ E+
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159
Query: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 822
+E+ + A DG R ++ + V+D++DNSPVF + Y V EN P+GTT++ + A
Sbjct: 3160 HEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNAT 3219
Query: 823 DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 880
D D G N ++Y ++S + F + P TG ++ LD+E + S V+AF++
Sbjct: 3220 DADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET----KQSYHLTVKAFNVP 3274
Query: 881 GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASR 940
ATV + +K N+Y P F ++Y ++ A KGT + V+A D D
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG--TDGE 3332
Query: 941 VRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA--FDDGEPVMSSSA 998
V Y + F++ + +G++ L+ E L V+A F
Sbjct: 3333 VHYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEV 3389
Query: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-----QSIVYSIVSGN 1053
TV + VL + P FT Y +SE GT V +SA + Y I SGN
Sbjct: 3390 TVNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGN 3448
Query: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
E F IN TG I V LD ET Y +L V+ + PS + +A + + ++
Sbjct: 3449 ENGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAVDSGTPSATGSASLLVTLE 3501
Query: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNYSVMAYRLIIPPIKEGKEG 1172
D N++ P+ G V E+ R T V+ +++TD D N Y L+
Sbjct: 3502 DINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL--STGPATSY 3557
Query: 1173 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
F + T G++ T + + F V+ D +S V ++V++Q D
Sbjct: 3558 FSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Score = 283 bits (724), Expect = 1e-75
Identities = 267/925 (28%), Positives = 409/925 (44%), Gaps = 83/925 (8%)
Query: 359 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD-KDIEDTKDP 417
+ + + D N+ +P F PS E + G + S + +D + +
Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180
Query: 418 ELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP----- 470
E F D T+ +G +L L+ +DRE Y + D + EP
Sbjct: 181 EAGRFRLD----ITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGY 233
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
+ VN+ V D NDN P F Y V D G SV+Q+ A DADEG+N +I Y L
Sbjct: 234 LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDE 292
Query: 531 QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 590
F ++ TGLIT+ ++ R Y+LTVQA D P+ I++L N+
Sbjct: 293 GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEALIQLLDVNDND 350
Query: 591 P----PRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLS 642
P FP + E +VG V+ L TD + +I+ I G+ QR F +
Sbjct: 351 PVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQ 410
Query: 643 ET----TGILTLGKALDRESTDRYILIITASD--GRPDG------TSTATVNIVVTDVND 690
+ ++ + ALDRE Y L ++ SD G P G +S A++ I V D+ND
Sbjct: 411 SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 691 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGS 748
+ PVF + R E ++V + ATD D+G+N + YS+ + N L F I+ +
Sbjct: 471 HPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530
Query: 749 IYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 804
+ T L+RE+ L + A D VHP+ S L + +LD++D PVF+ Y V
Sbjct: 531 LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590
Query: 805 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSLLRSLDYE 861
V EN P GT +L + A D DLG N + R E + F L P +G LS + SLD E
Sbjct: 591 SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
++A + LV A D+ +A + V + D+ND PVF Y + + G+
Sbjct: 651 ----EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGS 706
Query: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
ITTV A D D V+Y + S F+V SG + TR+ L+ E T ++
Sbjct: 707 YITTVSATDPDLG--TNGTVKYSIS----AGDRSRFQVNAQSGVISTRMALDREEKTAYQ 760
Query: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1040
L +VA D G + A V I VL + P + V E G VG +SA+
Sbjct: 761 LQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTM 820
Query: 1041 -INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1099
+N +I Y I +G+++ F IN +TG + +D E ++ Y L+V A V
Sbjct: 821 DLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV------- 873
Query: 1100 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1159
+ V I ++D N++ P F + V E+ + S+ + KA D D G ++ Y
Sbjct: 874 ---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLY 930
Query: 1160 RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV- 1218
L P K F + G I ++ ++ +++A+D LS + V
Sbjct: 931 SLKQNP----KNLFAINEKNGTISLLGPL-DVHAGSYQIEILASDMGVPQLSSSVILTVY 985
Query: 1219 --------SVVNQLDMQVIVSNVPP 1235
V +QL +V +S P
Sbjct: 986 VHDVNDNSPVFDQLSYEVTLSESEP 1010
Score = 268 bits (686), Expect = 3e-71
Identities = 283/1042 (27%), Positives = 475/1042 (45%), Gaps = 112/1042 (10%)
Query: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
Y ++ I V D NDN+P FK + + + + E L+P I T A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704
Query: 167 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Y I + ++F I TG I + L+ E + Y + I+++D+ + ++T+
Sbjct: 2705 YEIV----NGNMENSFSIN-HATGEIRSVRPLDREKVSHYVLTIKSSDKG---SPSQSTS 2756
Query: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
+ +++LD +D P F + A +PE +P VT D
Sbjct: 2757 VKVMINILDENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----D 2798
Query: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 346
+D I S YSI+ D F ++P T ++ + P+NR+ ++ + + A
Sbjct: 2799 EDIGINAISR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848
Query: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
D+G + + I + D N+ +P F+ SY E +G+ ++ ++ A
Sbjct: 2849 -DSGWTVST--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFA 2896
Query: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQTYTFSIT 460
D D + + ++ F+ + F + T + + Q V ++F +T
Sbjct: 2897 TDPD--EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954
Query: 461 AFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEG 517
+ D + S V I ++D+NDN P F + Y V +++ G +I++TA+D D G
Sbjct: 2955 SSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFG 3014
Query: 518 SNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 576
N E+ Y I G F ++ TG I++A + + + + +TV A D P +S
Sbjct: 3015 LNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQ 3072
Query: 577 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENG 633
TV+I V N +P F Q S I E+ +G+++ + A DR+ I Y+I +G
Sbjct: 3073 ATVHITVTEENYHTP-EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSG 3131
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVND 690
+ + +F ++ +TGILTL KALD E ++ + I+A DG G + TVN++ DVND
Sbjct: 3132 NEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVND 3189
Query: 691 NAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN- 746
N+PVF D Y P L + V + ATD D+G N + Y++ + ++LF I N
Sbjct: 3190 NSPVFLSDDYFPTVLE--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNT 3247
Query: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
G I T L+ E + Y L V A + R S T+ I++ ++ P F + Y +
Sbjct: 3248 GVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEI 3307
Query: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 864
E P GT + ++ A D DLG + V Y I K F ++ TG++ + LD E
Sbjct: 3308 SEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK-- 3365
Query: 865 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 924
++ S+ L + F TV V V D ND PP+F+ IY ++ GT +T
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVT 3424
Query: 925 TVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
V A D+D +P+ SR Y + F + +G++ L+ E I+ L
Sbjct: 3425 FVSAFDSD--SIPSWSRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 984 VVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA--- 1039
V+A D G P + SA++ + + + P T E V E GT+V + +
Sbjct: 3480 VLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMTLQSTDPD 3536
Query: 1040 -AINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
NQ Y ++S ++ + GV+ +D E + L VV +
Sbjct: 3537 LPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL-------SVVTKDS 3589
Query: 1098 RVPSKSNTAKVYIEIQDENNHP 1119
VP S+T V+I + D+N++P
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDNP 3611
Score = 260 bits (665), Expect = 8e-69
Identities = 303/1158 (26%), Positives = 498/1158 (43%), Gaps = 135/1158 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 169
V + ++D NDN+P F + Y AT++E T + A+D+D+G NG I Y +I
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV-----SASDVDEGNNGLIHYSII 1250
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ-NLNERRTTTTT 228
+ N + + D+ +G + L +L+YE Y ++IQA D LN +T T
Sbjct: 1251 KGNEERQFAIDS------TSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLN----STCT 1300
Query: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
L +D+LD +D P F L + + +R E ++ + T D D
Sbjct: 1301 LNIDILDENDNTPSFPKSTL-----------FVDVLENMRIGELVSSVTAT------DSD 1343
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
D + YSI T + F + P T + L + ++ + + L I A+
Sbjct: 1344 SG-----DNADLYYSI---TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ 1395
Query: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
P + + I + D N+ P F I+E+ P+G TS + + A D
Sbjct: 1396 GRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIG---------TSVISVTAHD 1446
Query: 409 KDIEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 467
D + + + FT+ + T Y +DRE + ++ A D
Sbjct: 1447 PDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNA--EIDREFANLFELTVKANDQAVP 1504
Query: 468 SEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ-LTAVDADEGSNGE 521
E V I V D NDN P F IS + SV+ + A D DEG+NGE
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPDEGANGE 1562
Query: 522 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
I YEI+ G FI+++ +G + +A + + Y L V A D P + + T+ +
Sbjct: 1563 IEYEIINGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIIL 1621
Query: 582 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-------ITYAIENGD 634
+ L P F Q Y + E +G +++++A G ++ E
Sbjct: 1622 QGL-----DGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT 1676
Query: 635 PQRVFNLSETTGILTLGKALDRESTDRYILI----ITASDGRPDGTSTATVNIVVTDVND 690
R+F + TGI+ LDRE L+ I S P T A V I + D+ND
Sbjct: 1677 VGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFP-RTQRAEVEITLQDIND 1735
Query: 691 NAPVFDPYLPRNLSVVEEEAN-AFVGQVKATDPDAGINGQVHYS-LGNFNNLFRI-TSNG 747
N PVF P +L+V E + + + Q+ A D D G N V Y+ + ++ FRI +G
Sbjct: 1736 NPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESG 1794
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
+ +L+RE R Y L+V A DG + S + + I V D++D++P F+ Y+ +
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851
Query: 808 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 865
E+ G+ + I A D D G N ++Y + + F L+P TG +L R LDYE
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV--- 1908
Query: 866 QEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
+ V A D G T+ V + D+ND PP+FS Y + + G+ +
Sbjct: 1909 -QQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTV 1963
Query: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKL 982
DAD G+ S++ Y + S+ + D V+ + L+ E + + L
Sbjct: 1964 LVFNVTDAD-DGI-NSQLTYSIASGD-----SLGQFTVDKNGVLKVLKALDRESQSFYNL 2016
Query: 983 VVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEE--YRP--PPVSELATKGTMVG 1034
VV D + S S+A V I++L + P F + Y P P+ + K
Sbjct: 2017 VVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATD 2076
Query: 1035 VISAAAINQSIVYSIVS--GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1092
S N I Y++++ GN+ F I I G + + G LD E ++Y +L V
Sbjct: 2077 PDSGP--NSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNY-------TLTV 2124
Query: 1093 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1152
V + PS S++ +V + + D N++ P+F + Y ++E+ T +++V A D D G
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184
Query: 1153 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1212
+ Y ++ + F +++ TG I A + + V ATD +G +
Sbjct: 2185 TNGQVRYGIV---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD---RGSTP 2238
Query: 1213 KADVLVSVVNQLDMQVIV 1230
+ D + LD+ V
Sbjct: 2239 RTDTSTVSIVLLDINDFV 2256
Score = 250 bits (639), Expect = 8e-66
Identities = 288/1091 (26%), Positives = 459/1091 (42%), Gaps = 109/1091 (9%)
Query: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 167
Y +V + V+D NDN P F Y A V E VG+++ A D D+G N I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287
Query: 168 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 227
+Q + P D TG I +R+ L++E + +Y + +QA DR R
Sbjct: 288 RLQ-DEGTPFQMDP------ETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL 340
Query: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
+DV D D P+ P ++ + A+
Sbjct: 341 IQLLDVNDND-------------------PVVKFRYFPATSRYASVDENAQVGTVVALLT 381
Query: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMH----PRTAELSLLEPVNRDFHQKFDLVI 343
+ P+ I IL G + R F + P + + + ++R+ ++L +
Sbjct: 382 VTDADSPAANGNISVQILGGNEQ---RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTV 438
Query: 344 KAEQDNGHPLPA-------FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 396
+ G P A A L I + D N+ P F+ Y+ + E AP G+ +S
Sbjct: 439 SVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG-- 496
Query: 397 NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 456
I A D D + + + F +++ +DRE
Sbjct: 497 -------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIV 549
Query: 457 FSITAFDGVQESEPVI----VNIQVMDANDNTPTF--PEISYDVYVYTDMRPGDSVIQLT 510
+I+A D Q P + + + ++D ND P F PE YDV V + G ++ L
Sbjct: 550 LNISARD--QGVHPKVSYAQLVVTLLDVNDEKPVFSQPE-GYDVSVVENAPTGTELLMLR 606
Query: 511 AVDADEGSNGEITYEILVGAQGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 567
A D D G NG + + L A+ D F ++ +G ++ ++ Y+L V A D
Sbjct: 607 ATDGDLGDNGTVRFS-LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665
Query: 568 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 624
P + +S+ + + +L N+ SP +P + Y I E G+ + + ATD +
Sbjct: 666 SPPQ--SSMARINVSLLDINDNSPVFYP-VQYFAHIKENEPGGSYITTVSATDPDLGTNG 722
Query: 625 SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683
++ Y+I GD R F ++ +G+++ ALDRE Y L I A+D G + A V I
Sbjct: 723 TVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 684 VVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFR 742
V D DN PVF + + V E A + VG V A+ D N + G+ +F
Sbjct: 782 TVLDTQDNPPVFS-QVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFA 840
Query: 743 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
I G + TA ++RE + +Y+L VVA+ G V + I V D++DNSP F +
Sbjct: 841 INQVTGQLTTANVIDREEQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAI 897
Query: 802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
+V V EN AG +I Q +A D D G N V Y ++ K+ FA++ G +SLL LD
Sbjct: 898 ESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD 956
Query: 860 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 919
A S + A D+ +TV V D+ND PVF + Y+ ++
Sbjct: 957 VHA-----GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPV 1011
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ V A D D + Y + + IF G++ + L+ E
Sbjct: 1012 NSRFFKVQASDKDSGA--NGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDR 1065
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA 1038
+ L+VVA D +S++ V +++ + P F Y E G+ VG +SA
Sbjct: 1066 YVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKVSA 1124
Query: 1039 A----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEV 1092
N + YS + F ++ I+G I D R S + R S V
Sbjct: 1125 VDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFD---RESLMRRRGTAVFSFTV 1179
Query: 1093 VLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
+ + +P + A V++ ++D N++ P F K FY +SE A T VLRV A+D D
Sbjct: 1180 IATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDE 1239
Query: 1152 GNYSVMAYRLI 1162
GN ++ Y +I
Sbjct: 1240 GNNGLIHYSII 1250
Score = 234 bits (598), Expect = 5e-61
Identities = 238/874 (27%), Positives = 378/874 (43%), Gaps = 99/874 (11%)
Query: 59 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDR 118
+ + +MD STG ++ P + +++ G + +V I V D
Sbjct: 2806 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865
Query: 119 NDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 178
NDN+P F SYY ELT +G+ + F ATD D+G NGQ+ Y I+ +
Sbjct: 2866 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF-----ATDPDEGSNGQVFYFIKSQSEYFRI 2920
Query: 179 NDTFEIPLMLTGNIVLRKRLNYEDKT--------RYFVIIQANDRAQNLNERRTTTTTLT 230
N T TG I ++ L Y++ T R+ I+ ++DR + + TT+T
Sbjct: 2921 NAT-------TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK---PSLISETTVT 2970
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ--AIDQD 288
++++D +D P FL + TP N + T I+ AID D
Sbjct: 2971 INIVDSNDNAPQFLK-------------------SKYFTPVTKNVKVGTKLIRVTAID-D 3010
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
++ S+ + Y I + +++ F + T +S+ + D +Q F + + A+
Sbjct: 3011 KDFGLNSE---VEYFI---SNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDK 3064
Query: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
PL + A +HI + +EN +P F+ I ES +G+ + + A D
Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR---------TVSARD 3115
Query: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
+D + + + +F + + T LTL + +D E Q + +I+A DG V
Sbjct: 3116 RDAAMNGLIKYSISSGNEEGIFAINSS--TGILTLAKALDYELCQKHEMTISAIDGGWVA 3173
Query: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
+ V + V+D NDN+P F Y V + G +VI L A DAD G+N I Y +
Sbjct: 3174 RTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTV 3233
Query: 527 LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
F+I+ TG+IT ++ ++Y LTV+A + P E R S TV I+ L
Sbjct: 3234 QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQ-LKG 3290
Query: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSE 643
N+ PRF +Y EISEA G ++ + A+DR+ + Y I ++ F +++
Sbjct: 3291 TNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK 3350
Query: 644 TTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLP 700
TG + + LDRE +R L + A + R TVN+ V D ND P
Sbjct: 3351 KTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-----PPIFT 3405
Query: 701 RNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYT 751
N+ V+ +G V A D D+ I +S GN N F I G I
Sbjct: 3406 LNIYSVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSINPQTGQITV 3464
Query: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
+L+RE Y L V+A D + +L + + DI+DN P+ T S V+ EN
Sbjct: 3465 TAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKR 3522
Query: 812 AGTTILQIEAKDVDLGAN----VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 867
GT ++ +++ D DL N Y + + +F+L G LS R +D E D
Sbjct: 3523 PGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFY 3581
Query: 868 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 901
S+ D TV + V D ND P
Sbjct: 3582 LSVV----TKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 216 bits (550), Expect = 2e-55
Identities = 244/842 (28%), Positives = 373/842 (44%), Gaps = 76/842 (9%)
Query: 423 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 482
L++ ++F + + Y T +DRE + ++ + P V + V D ND
Sbjct: 74 LSESHALFAINSSTGALYTT--STIDRESLPSDVINLVVLSSAP-TYPTEVRVLVRDLND 130
Query: 483 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--EITYEILVGAQ-GDFIINKT 539
N P FP+ S V D G VI TA D+D GSNG +Y I+ G + G F ++ T
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190
Query: 540 TG--------LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 591
+ G++ V Y L V+ D P R V ++ + N +P
Sbjct: 191 LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI---NDNP 247
Query: 592 PRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSETTGILTL 650
P F Y + E VG+ +L + A D EG + D F + TG++T+
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITV 307
Query: 651 GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEE 708
+ LD E+ +Y L + A D G P T A I + DVNDN PV Y P
Sbjct: 308 REPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASV 367
Query: 709 EANAFVGQVKA----TDPDA-GINGQVHYSL--GNFNNLFRITSN-----GSIYTAVKLN 756
+ NA VG V A TD D+ NG + + GN F + S+ I A L+
Sbjct: 368 DENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALD 427
Query: 757 REVRDYYELVVVATD-------GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 809
RE Y L V +D AV R S +L I V DI+D+ PVF+ Y V + E
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487
Query: 810 LPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPD 865
P G+ + I A D D L AN+ Y I S +F + +G ++ S LD E
Sbjct: 488 APPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL--- 544
Query: 866 QEASITFLVEAFDIYGTMPP-GIATVTVIVKDMNDYPPVFSK-RIYKGMVAPDAVKGTPI 923
+ I + A D G P A + V + D+ND PVFS+ Y V +A GT +
Sbjct: 545 -ASQIVLNISARD-QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602
Query: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
+ A D D VR+ + + + + F ++ SGR+ T +L+ E + L+
Sbjct: 603 LMLRATDGDLG--DNGTVRFSLQEAETDRRS--FRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 984 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA--- 1039
V+A D G P SS A + + +L + P F +Y + E G+ + +SA
Sbjct: 659 VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPD 717
Query: 1040 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
N ++ YSI +G + F +N +GVI LD E +T+Y L++ A NL+
Sbjct: 718 LGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD----GGNLQ 772
Query: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
P N A V I + D ++PPVF + Y V E+ + V V A+ D S ++
Sbjct: 773 SP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNIS 827
Query: 1159 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Y LI ++G F + TG + TA + +S+++ +V+A+ G ++G V +
Sbjct: 828 Y-LITTGDQKGM--FAINQVTGQLTTANVIDREEQSFYQLKVVAS---GGTVTGDTMVNI 881
Query: 1219 SV 1220
+V
Sbjct: 882 TV 883
Score = 186 bits (471), Expect = 2e-46
Identities = 205/752 (27%), Positives = 325/752 (43%), Gaps = 78/752 (10%)
Query: 534 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP--PAERRNSICTVYIEVLPPNNQSP 591
F IN +TG + ++ + + + +AP P E R V + L N +
Sbjct: 81 FAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR-----VLVRDL---NDNA 132
Query: 592 PRFPQLMYSLEISEAMRVGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTG 646
P FP + E G ++ ATD + D +Y I G+ F L T
Sbjct: 133 PVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN 192
Query: 647 ILTLGK--------ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 697
G LDRE T +Y L++ D G P VN+ V D+NDN PVF
Sbjct: 193 PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS 252
Query: 698 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVK 754
+ V E+A + V QV A D D G N + Y L + F++ G I
Sbjct: 253 --SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310
Query: 755 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-----FTNSTYTVLVEEN 809
L+ E R Y L V A D V I++LD++DN PV F ++ V+EN
Sbjct: 311 LDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDEN 370
Query: 810 LPAGTTILQIEAKDVDLGA---NVSYRIRSP-EVKHFFALHPFTGELSLLR---SLDYEA 862
GT + + D D A N+S +I E +HF LSL++ +LD E
Sbjct: 371 AQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRER 430
Query: 863 FPDQEASITFLVEAFDIYGTMPPG--------IATVTVIVKDMNDYPPVFSKRIYKGMVA 914
P S V D YG PPG +A++ + V D+ND+PPVFS+++Y+ ++
Sbjct: 431 IP----SYNLTVSVSDNYGA-PPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLS 485
Query: 915 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--L 972
+A G+ ++ + A D D GL A+ +RY + F + E SG V T + L
Sbjct: 486 EEAPPGSYVSGISATDGDS-GLNAN-LRYSIVSGN---GLGWFHISEHSGLVTTGSSGGL 540
Query: 973 NEEPTTIFKLVVVAFDDG-EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1031
+ E + L + A D G P +S + V L+ E P F+Q E V E A GT
Sbjct: 541 DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600
Query: 1032 MVGVISAA----AINQSIVYSIVSGN-EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1086
+ ++ A N ++ +S+ + +F ++ ++G + LD E + Y
Sbjct: 601 ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFY----- 655
Query: 1087 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1146
SL V+ +L P +S+ A++ + + D N++ PVF Y + E+ + + V A
Sbjct: 656 --SLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSA 713
Query: 1147 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
TD D G + Y + + F V +G+I T M ++ ++ Q++ATD
Sbjct: 714 TDPDLGTNGTVKYSISAGD----RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769
Query: 1207 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
+A V ++V++ D + S V + V
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Score = 172 bits (436), Expect = 3e-42
Identities = 186/645 (28%), Positives = 296/645 (45%), Gaps = 61/645 (9%)
Query: 616 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 675
L T + TY + + +F ++ +TG L +DRES ++ + P
Sbjct: 60 LVGTIQTRPGFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP-- 115
Query: 676 TSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQVH 731
T V ++V D+NDNAPVF DP ++ V +E ++ QV ATD D G NG H
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVDH 171
Query: 732 YSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPRH 778
S GN FR IT N S + + L+REV Y+L+V D R
Sbjct: 172 RSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRR 231
Query: 779 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 838
L + + V DI+DN PVF +S Y V E+ G+++LQ+ A D D G N R R +
Sbjct: 232 GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD 291
Query: 839 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
F + P TG +++ LD+EA ++ S+T V+A D G A + + D+N
Sbjct: 292 EGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDVN 347
Query: 899 DYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFPY 952
D PV R + V +A GT + + DAD P + V+ + Q +
Sbjct: 348 DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF 407
Query: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHPG 1008
+V S + L+ E + L V D+ G P + + ++V LV+
Sbjct: 408 EVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVN 466
Query: 1009 EI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGI 1060
+I P F+Q+ YR +SE A G+ V ISA + +N ++ YSIVSGN F I
Sbjct: 467 DINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 1061 NNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
+ +G++ +G LD E + VL + A + V K + A++ + + D N+
Sbjct: 526 SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVNDE 578
Query: 1119 PPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
PVF Q + Y V E+A T +L ++ATD D G+ + R + + + F ++
Sbjct: 579 KPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLDP 636
Query: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1222
+G + T ++++ V+ATD S A + VS+++
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Score = 169 bits (429), Expect = 2e-41
Identities = 196/756 (25%), Positives = 323/756 (42%), Gaps = 74/756 (9%)
Query: 87 MNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 146
+N HS +V K I V I + D NDN+P F Y+ V + VGT +
Sbjct: 2946 INRHSFIV-TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004
Query: 147 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDK 203
+ D D D G N ++EY I SND L TG I + L +
Sbjct: 3005 VTAID----DKDFGLNSEVEYFI--------SNDNHLGKFKLDNDTGWISVASSLISDLN 3052
Query: 204 TRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 263
+F+ + A D+ N ++ T+ + V + + P F + A
Sbjct: 3053 QNFFITVTAKDKG---NPPLSSQATVHITVTEENYHTPEFSQSHM------------SAT 3097
Query: 264 IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 323
IPE + I+ T + A D+D + I YSI G E F ++ T
Sbjct: 3098 IPE---SHSIGSIVRT--VSARDRDAAMNGL-----IKYSISSGNEEG---IFAINSSTG 3144
Query: 324 ELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 383
L+L + ++ + QK ++ I A + + + ++D N+ SP F Y +L
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204
Query: 384 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 443
E+AP G T+ + + A D D T + + + +F + T +T
Sbjct: 3205 ENAPSGTTV---------IHLNATDAD-SGTNAVIAYTVQSSDSDLFVIDPN--TGVITT 3252
Query: 444 LQPVDREEQQTYTFSITAFDGVQESEP--VIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
+D E +Q+Y ++ AF+ E VNIQ+ N+ P F Y +
Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312
Query: 502 PGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALT 560
G V ++ A D D G++GE+ Y I + + F INK TG I ++ ++ +L
Sbjct: 3313 KGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372
Query: 561 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 620
V A + TV + VL N+ PP F +YS++ISE + +G + + A D
Sbjct: 3373 VLAKNFGSIRGADIDEVTVNVTVLDAND--PPIFTLNIYSVQISEGVPIGTHVTFVSAFD 3430
Query: 621 REG----DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 675
+ +Y I +G+ F+++ TG +T+ LDRE+ Y L + A D G P
Sbjct: 3431 SDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA 3490
Query: 676 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN-GQVHY-- 732
T +A++ + + D+NDN P+ + + + V +++TDPD N G Y
Sbjct: 3491 TGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYL 3548
Query: 733 -SLGNFNNLFRITSNGSIYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 790
S G + F +++ G + T +++RE + D+Y L VV D V ST T+ I V+D
Sbjct: 3549 LSTGPATSYFSLSTAGVLSTTREIDREQIADFY-LSVVTKDSGVPQMSSTGTVHITVIDQ 3607
Query: 791 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
+DN V NL G + ++ +D D+
Sbjct: 3608 NDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 153 bits (387), Expect = 1e-36
Identities = 184/709 (25%), Positives = 296/709 (41%), Gaps = 90/709 (12%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V I V + N ++P F AT+ E +G+ + T A D D NG I+Y I
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-----SARDRDAAMNGLIKYSIS 3129
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
++ F I TG + L K L+YE ++ + I A D RT ++T
Sbjct: 3130 SGNEE----GIFAINSS-TGILTLAKALDYELCQKHEMTISAIDGGW---VARTGYCSVT 3181
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
V+V+D +D P+FL P + P + ++ +Q+ D D
Sbjct: 3182 VNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-- 3239
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
F + P T ++ ++ + Q + L +KA
Sbjct: 3240 ------------------------LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPD 3275
Query: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
+FA ++I++ N P F Y I E+AP G + + + A D+D
Sbjct: 3276 EERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE---------VFASDRD 3326
Query: 411 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQ-- 466
+ + +F N F + + Y++ + +DRE+++ + + A F ++
Sbjct: 3327 LGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLAKNFGSIRGA 3384
Query: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE-GSNGEITYE 525
+ + V VN+ V+DAND P F Y V + + G V ++A D+D S +Y
Sbjct: 3385 DIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYF 3443
Query: 526 ILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
I G + G F IN TG IT+ ++ Y L+V A D+ P+ ++ V +E +
Sbjct: 3444 IGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDI 3503
Query: 585 PPNNQSPPRFPQLMYSL-EISEAMRVGAVLLNLQATD-----REGDSITYAIENGDPQRV 638
N P L S E+ E R G +++ LQ+TD +G Y + G
Sbjct: 3504 NDNG------PMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSY 3557
Query: 639 FNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDP 697
F+LS T G+L+ + +DRE D Y+ ++T G P +ST TV+I V D NDN P
Sbjct: 3558 FSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-----P 3611
Query: 698 YLPRNLSV-VEEEANAF----VGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYT 751
R + + V N F +G VK DPD + H SL +LF I G
Sbjct: 3612 SQSRTVEIFVNYYGNLFPGGILGSVKPQDPD--VLDSFHCSLTSGVTSLFSIP--GGTCD 3667
Query: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 800
R ++L V++ DG HST+T I+V ++ NS
Sbjct: 3668 LNSQPRSTDGTFDLTVLSNDGV----HSTVTSNIRVFFAGFSNATVDNS 3712
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 324 bits (830), Expect = 6e-88
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 77 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 136
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 137 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 196
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
Query: 197 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 253
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
Query: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
++Y + T + AID D + + Y I+ G
Sbjct: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
Query: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 365
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
Query: 366 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
E+ ++++ Y +S P + + L +
Sbjct: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
Query: 399 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
Query: 458 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
Query: 516 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
Query: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 632
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
Query: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 690
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
Query: 691 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 744
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
Query: 745 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
Query: 804 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 860
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
Query: 861 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 916
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
Query: 917 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
Query: 976 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1032
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1091
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 1092 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
Query: 1152 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
Query: 1212 GKADVLVSVVNQLDMQVIVSN 1232
A V+V+V + D +N
Sbjct: 1548 NLARVIVNVEDANDHSPYFTN 1568
Score = 311 bits (796), Expect = 5e-84
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 227
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
Query: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
Query: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
D I YS+ + P + N+ + +KA
Sbjct: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
Query: 348 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
Query: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 463
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
Query: 464 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
Query: 524 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 634
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
Query: 635 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
Query: 693 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 750
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
Query: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
Query: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
Query: 869 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
Query: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
Query: 988 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1042
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
Query: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
Query: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
Query: 1163 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 310 bits (795), Expect = 7e-84
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
Query: 353 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
Query: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
Query: 527 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
Query: 585 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 639
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
Query: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 695
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
Query: 696 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 751
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
Query: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
Query: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 868
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
Query: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
Query: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 984
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
Query: 985 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
Query: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
Query: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1156
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
Query: 1157 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
Query: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1257
+++++V N P + + + + +L YV ++
Sbjct: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
Score = 271 bits (694), Expect = 3e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 227
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
Query: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
L V + ++ P VP + + P TY +VT + +D
Sbjct: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
Query: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 344
N + S SI+ G P D E + E D F ++L ++
Sbjct: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 345 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
A+ D G P A ++I + F Y I E +P G
Sbjct: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
Query: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
Query: 462 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 521
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 522 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 580
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
Query: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 639
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
Query: 640 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 686
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
Query: 687 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 712
+N P FD P +++V E+ A
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 769
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
Query: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 829
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
Query: 830 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 885
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
Query: 886 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 944
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
Query: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Query: 1004 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1053
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
Query: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
Query: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1173
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
Query: 1174 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
Score = 271 bits (694), Expect = 3e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
SD + YSIL G F M ++ ++L + + L +
Sbjct: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
Query: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
Query: 411 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 467
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
Query: 468 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 527
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
Query: 528 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 638
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 696
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
Query: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 749
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
Query: 750 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
Query: 809 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 863
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
Query: 864 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
Query: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
Query: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
Query: 1039 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
Query: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
Query: 1159 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Query: 1219 SVVNQLD 1225
++ + D
Sbjct: 3330 NLTDVND 3336
Score = 261 bits (668), Expect = 4e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 59 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 113
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
Query: 114 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 173
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
Query: 174 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 233
+ D EI D +++ + N N+ + T + V
Sbjct: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
Query: 234 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
+DG L P+++ VL P T +P + I I +
Sbjct: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
Query: 289 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 342
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
Query: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
Query: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
Query: 463 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 518
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
Query: 519 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
Query: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 632
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
Query: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
Query: 693 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 747
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 806
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
Query: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 864
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
Query: 865 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 924
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
Query: 925 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 984
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
Query: 985 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
Query: 1044 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
Query: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
Query: 1159 YRLIIPPIKEGKEGFVVETYTGLI 1182
+ L E K F V ++ G I
Sbjct: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
Score = 259 bits (662), Expect = 2e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 106
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
Query: 107 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 164
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
Query: 165 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 224
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
Query: 225 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
Query: 283 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Query: 342 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
Query: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 460
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
Query: 461 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 516
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
Query: 517 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
Query: 576 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
Query: 694 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 747
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
Query: 808 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 865
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
Query: 866 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
Query: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
Query: 984 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1041
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
Query: 1042 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1090
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
Query: 1091 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
Query: 1151 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
Score = 256 bits (655), Expect = 1e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
Query: 351 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 380
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
Query: 381 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 417
Y L + + DS + ++ L KD +++ D
Sbjct: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Query: 418 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 443
LH + Y++ + T IT+ T
Sbjct: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
Query: 444 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
Query: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 559
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
Query: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
Query: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
Query: 680 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 734
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
Query: 735 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Query: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
Query: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
Query: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
Query: 971 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1027
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
Query: 1028 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
Query: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
Query: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1198
V ++ +S + E +G FV+E TG IK F F
Sbjct: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
Query: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1258
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
Score = 253 bits (647), Expect = 1e-66
Identities = 284/1096 (25%), Positives = 477/1096 (43%), Gaps = 112/1096 (10%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
Query: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
Query: 410 D--IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 467
I + KD D +FT+ + +T + +D E +Y I A +
Sbjct: 1699 STLIYEVKD-------GDINGIFTINP--YSGVITTQKALDYERTSSYQLIIQATNMAGM 1749
Query: 468 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGSN 519
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD N
Sbjct: 1750 ASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNRN 1808
Query: 520 GEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
+ Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 1809 ALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVE 1868
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDP 635
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 1869 VNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927
Query: 636 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 695
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+ F
Sbjct: 1928 DH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHF 1982
Query: 696 DPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--TA 752
S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 1983 TQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG 2039
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 2040 VPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEP 2099
Query: 813 GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
GT I Q+ A D D G N + F ++P +G + L EAF ++I +
Sbjct: 2100 GTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIEY 2154
Query: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
V G P +V + + +N PVF K Y V D TPI ++ A +
Sbjct: 2155 GVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE 2214
Query: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 2215 GQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDALT 2265
Query: 993 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVYS 1048
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 2266 GARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQ 2325
Query: 1049 IVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 2326 IVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSEV 2378
Query: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL---S 2435
Query: 1167 KEGKEGFVVETYTGLI 1182
+ F++++ +G+I
Sbjct: 2436 GNDRTSFLMDSKSGVI 2451
Score = 238 bits (607), Expect = 4e-62
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
Query: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
Query: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
Query: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 371
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
Query: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 424
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
Query: 425 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 481
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
Query: 482 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 538
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
Query: 539 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 598
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 599 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 654
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Query: 655 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
Query: 714 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
Query: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 821
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
Query: 822 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
+ L + I F G + + + LD E Q + VE D G
Sbjct: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
Query: 882 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
Query: 940 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 999
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
Query: 1000 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1054
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
Query: 1055 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
Query: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1172
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
Query: 1173 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
Score = 186 bits (473), Expect = 1e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
Query: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
Query: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
Query: 502 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 553
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
Query: 554 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 613
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Query: 614 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
Query: 674 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
Query: 729 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 784
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 844
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
Query: 845 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 893
L+P +G L L +SL + + + A D P ++V+
Sbjct: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
Query: 894 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 921
+N P F K + V D G
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
Query: 982 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1040
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
Query: 1041 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1093
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
Query: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
Query: 1214 ADVLVSVVNQLDMQVIVSN 1232
V +S V+ ++++V+ N
Sbjct: 1017 RPVSLSSVSFVEVEVVDVN 1035
Score = 174 bits (441), Expect = 8e-43
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 447 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 565
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
Query: 566 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
N + + +Y+ + N +P + + V ++
Sbjct: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
Query: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 675
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
Query: 676 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 735
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
Query: 736 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
Query: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 852
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
Query: 853 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 910
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
Query: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 962
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
Query: 963 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1004
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
Query: 1005 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1044
L G + P F + V E G + I A + N
Sbjct: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
Query: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
Query: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
Query: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Query: 1225 DMQVIVSNVPPTLVEKKIEDL 1245
+ +P + K +EDL
Sbjct: 929 VNDCSPAFIPSSYSVKVLEDL 949
Score = 168 bits (426), Expect = 4e-41
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 198 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 257
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
Query: 258 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 317
TY I E TP + VT A D D G Y + F
Sbjct: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
Query: 318 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 370
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
Query: 371 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 427
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
Query: 428 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 479
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
Query: 480 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 535
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
Query: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
Query: 596 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 652
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Query: 653 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
Query: 710 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 766
+ V A D D + GN F + + + K N +++ + L
Sbjct: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
Query: 767 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 788
+ ATDG +H + S+ + LA K+L
Sbjct: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
Query: 789 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 841
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
Query: 842 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 901
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
Query: 902 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 960
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
Query: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1017
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
Query: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1073
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Query: 1074 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1131
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 1132 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1191
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
Query: 1192 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1248
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Score = 145 bits (367), Expect = 3e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
Query: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
Query: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
Query: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
Query: 404 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
Query: 462 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
Query: 520 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 637
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
Query: 638 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 672
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
Score = 102 bits (253), Expect = 5e-21
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 483 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 536
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
Query: 537 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
Query: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 648
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
Query: 649 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
Query: 703 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 758
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
Query: 759 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 811
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
Query: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
Query: 872 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 929
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 930 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 988
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
Query: 989 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1045
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
Query: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1094
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 1095 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1128
+ +V SKS N +++ N P F K F
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 1129 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1185
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
Query: 1186 M 1186
M
Sbjct: 787 M 787
Score = 52.0 bits (123), Expect = 6e-06
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 1036 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1093
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1208
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Query: 1209 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1247
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 314 bits (805), Expect = 5e-85
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
Query: 351 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
Query: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
Query: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
Query: 525 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
Query: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 632
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
Query: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
Query: 693 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 806
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
Query: 807 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 863
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
Query: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
Query: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
Query: 984 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1042
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
Query: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
Query: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1155
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
Query: 1156 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
Query: 1216 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1263
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
Query: 1264 ---VESIGARRHGDAFSLEDYTKCDLTV 1288
+ SI G+ FS+ DY LTV
Sbjct: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
Score = 301 bits (771), Expect = 4e-81
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
V + D +D P F R Y+ I T ++ + D
Sbjct: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
Query: 350 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
Query: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
Query: 469 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
Query: 526 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
Query: 582 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 636
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
Query: 637 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
Query: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 752
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
Query: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
Query: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
Query: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
Query: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
Query: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
Query: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
Query: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
Query: 1225 DMQVIVSNV-PPTLVEKKI 1242
D++VI ++ PP ++ +I
Sbjct: 3532 DIRVIEESIYPPAILPLEI 3550
Score = 291 bits (746), Expect = 3e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 74 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 133
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 192
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
Query: 193 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
Query: 253 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
A+P P E I V P+ + + + + YSI G
Sbjct: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 364
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
Query: 365 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 422
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
Query: 423 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 480
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
Query: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 539
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
Query: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
Query: 600 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 654
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
Query: 655 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
Query: 714 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
Query: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
Query: 829 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 886
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
Query: 887 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 946
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
Query: 947 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1005
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Query: 1006 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1059
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
Query: 1060 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1117
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
Query: 1118 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
Query: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1208
TG +KT+ ++ + V ATD G+
Sbjct: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
Score = 288 bits (738), Expect = 3e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 94 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 153
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
Query: 154 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 212
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
Query: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 271
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
Query: 272 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 331
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
Query: 332 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 366
K L I A P + + + ++L
Sbjct: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
Query: 367 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
Query: 417 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 471
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
Query: 472 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 531
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
Query: 532 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 590
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
Query: 591 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 646
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
Query: 647 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 702
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
Query: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 759
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
Query: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 876
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
Query: 877 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 928
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
Query: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
Query: 989 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1045
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
Query: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1104
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
Query: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
Query: 1165 PIKEGKEGFVVETYTGLIKTA 1185
P+ K F ++ TG + T+
Sbjct: 1499 PLSLKK--FRLDPATGSLYTS 1517
Score = 258 bits (659), Expect = 4e-68
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 96 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
Query: 156 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 215
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 216 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 273
L + ++ LTV + ++ P+ L P+ D
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
Query: 274 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 331
+P + DQ N S SI+ G R P + E + + +
Sbjct: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
Query: 332 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 387
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
Query: 388 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 445
+ ++ S LR V P F +Y T +++L+
Sbjct: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
Query: 446 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
Query: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 564
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
Query: 565 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 622
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
Query: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 679
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
Query: 680 TVNIVVT-------------------------------------------DVNDNAPVFD 696
+NI V VN + P F
Sbjct: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
Query: 697 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 752
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
Query: 813 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
Query: 871 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
Query: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
Query: 989 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
Query: 1039 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
Query: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
Query: 1158 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1215
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Query: 1216 VLVSVVNQLD 1225
V+V ++++ D
Sbjct: 1231 VIVKILDEND 1240
Score = 258 bits (658), Expect = 5e-68
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
Query: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 435
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
Query: 436 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 491
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
Query: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 550
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
Query: 551 MIVGRT---YALTVQAADN---------------------------------------AP 568
+G ++L + A D A
Sbjct: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
Query: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
Query: 626 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 684
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
Query: 685 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 741
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
Query: 742 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 798
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
Query: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 855
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Query: 856 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 910
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
Query: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
Query: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1085
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
Query: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1137
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
Query: 1138 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1184
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
Score = 249 bits (637), Expect = 1e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Query: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
Query: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
Query: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 468
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
Query: 469 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 519
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
Query: 520 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
Query: 579 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 636
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
Query: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 696
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
Query: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 750
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
Query: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
Query: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
Query: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
Query: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 988
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
Query: 989 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1038
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
Query: 1039 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1094
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
Query: 1095 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1154
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
Query: 1155 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1211
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
Score = 243 bits (620), Expect = 1e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 168
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
Query: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
Query: 349 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
Query: 406 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 465
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
Query: 466 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 520
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
Query: 521 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 573
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
Query: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
Query: 694 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 746
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
Query: 747 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 805
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
Query: 806 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
Query: 864 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
Query: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 981
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
Query: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1039
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
Query: 1040 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1092
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
Query: 1093 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1152
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
Query: 1153 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1209
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
Query: 1210 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1265
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
Score = 240 bits (613), Expect = 9e-63
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 347
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
Query: 348 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 407 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
Query: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
Query: 523 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Query: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 635
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
Query: 636 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 694
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
Query: 695 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 748
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
Query: 749 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
Query: 809 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
Query: 860 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 916
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
Query: 917 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 976
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
Query: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1035
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
Query: 1036 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1092
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
Query: 1093 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
Query: 1151 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1209
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
Query: 1210 LSGKADVLVSVVNQ 1223
S + V ++V+N+
Sbjct: 2164 FSAEVIVPITVMNK 2177
Score = 219 bits (557), Expect = 3e-56
Identities = 281/1199 (23%), Positives = 500/1199 (41%), Gaps = 125/1199 (10%)
Query: 89 IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 146
++++ V+ + K V + Y EV +V + N + P F TV E PVG+ + T
Sbjct: 996 VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 147 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 206
A D D +G+I Y I+ D + F+I TG I RL+ E + Y
Sbjct: 1056 -----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIETSDRLDRESTSHY 1105
Query: 207 FVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE 266
++ + A D+ ++ + ++V D +D P V P +
Sbjct: 1106 WLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME------------ 1150
Query: 267 LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELS 326
+P++++ + I+A D D S ++Y I G P+ FF +HP+T ++
Sbjct: 1151 -NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLIT 1197
Query: 327 LL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 385
++R+ + L + + P A + ++ILDEN+ P F Y+ + E
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER 1257
Query: 386 APVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYL 441
+ PL ++A DKD + + E+ + N++ F +TG+
Sbjct: 1258 EKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312
Query: 442 TLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DM 500
+ + SI A D + + + + + P+ IS++ +T +
Sbjct: 1313 RFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTV 1367
Query: 501 RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 559
D V + V + E + ++I G F ++K TG I +A ++ Y L
Sbjct: 1368 MESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427
Query: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
TV+A D + V+I+V+ N+ P+F Y + I E +L + A
Sbjct: 1428 TVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPETEILQISAV 1481
Query: 620 DR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
D+ E + + Y +++ DP + F L TG L + LD E+ ++ L + D P
Sbjct: 1482 DQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPV 1541
Query: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
+ A + + V+D ND+AP F + + V QV A D D G N +V YS+
Sbjct: 1542 KRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI 1601
Query: 735 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
GN N F I GSI TA +L+R + Y+L+V ATD P ++ I V D
Sbjct: 1602 ESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661
Query: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 851
+ SP FT+ Y+V + E + G+ + + A ++V Y I+ F ++P +G
Sbjct: 1662 NASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNTGDAFDINPHSGT 1718
Query: 852 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKDMNDYPPVFSKRI 908
+ ++LD+E P + I GT G++T T + ++D ND PVF +
Sbjct: 1719 IITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAE 1769
Query: 909 YKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 961
Y G+++ A + + T + A DAD A V + V+ P + F ++
Sbjct: 1770 YTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE----PSVHTYFAIDS 1824
Query: 962 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHPGEIPRFTQEEYR 1019
+G + T ++L+ E T+IF V D G P + + +A V + V+ + P +
Sbjct: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
Query: 1020 PPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1075
+ KG V ++A + S ++YSI GN + F ++ TG + V
Sbjct: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT-- 1942
Query: 1076 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1135
+ R+ Y L V+A + V I +++ F + Y V E++
Sbjct: 1943 QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFTQDVYSAVVKENS 1992
Query: 1136 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK-TAMLFHNMRRS 1194
++ + A + Y ++ P + F + +G++ T F ++
Sbjct: 1993 TEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLSTTGTPFDREQQE 2045
Query: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYV 1253
F V T+++ V V V +Q D + N+P V K ++ ++ RYV
Sbjct: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI-RYV 2103
Score = 216 bits (549), Expect = 2e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
Query: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
Query: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
Query: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 371
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
Query: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
Query: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 486
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
Query: 487 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 545
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
Query: 546 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 605
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
Query: 606 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 661
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
Query: 662 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 713
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
Query: 714 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 770
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
Query: 771 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
Query: 828 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 887
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
Query: 888 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 947
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
Query: 948 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1007
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
Query: 1008 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1062
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
Query: 1063 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1122
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
Query: 1123 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1180
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
Query: 1181 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
Score = 179 bits (453), Expect = 3e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 388 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 444
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
Query: 445 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 503
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 504 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
Query: 564 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 618
AD + I TV+IE N +P + E+ V ++
Sbjct: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
Query: 619 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 670
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
Query: 671 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 720
G P S+ V V + PV + P N VV +A ++
Sbjct: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
Query: 721 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
Query: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 838
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
Query: 839 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 894
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
Query: 895 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 954
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
Query: 955 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 987
F + +SG + IT + T ++ + VA
Sbjct: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
Query: 988 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1029
+ G M + ++ LH GE IP+F V E
Sbjct: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
Query: 1030 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
Query: 1086 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 1146 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
Query: 1206 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1247
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
Score = 170 bits (431), Expect = 1e-41
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 169
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
Query: 170 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 281
R ++ + + D +D P F +A P T E P +
Sbjct: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
Query: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
Query: 342 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 398
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
Query: 459 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 516
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
Query: 517 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
Query: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 631
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
Query: 632 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 690
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
Query: 691 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 749
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
Query: 750 YTAVKLNREVRDYYELVVVATDG 772
A K ++ Y L V TDG
Sbjct: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
Score = 142 bits (359), Expect = 2e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
Query: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
Query: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
Query: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
Query: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
Query: 404 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 463
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
Query: 464 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 520
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
Query: 521 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 580
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
Query: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 637
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 683
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
Score = 129 bits (324), Expect = 3e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
Query: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
Query: 502 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 556
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
Query: 557 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 609
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Query: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
Query: 670 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 729
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
Query: 730 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 785
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
Query: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 845
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
Query: 846 HPFTGELSLLRSL 858
+P +G LSL RSL
Sbjct: 618 NPNSGVLSLKRSL 630
Score = 103 bits (256), Expect = 2e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 589 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 643
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Query: 644 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
Query: 694 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 747
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 802
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 854
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 911
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
Query: 912 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
Query: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1030
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
Query: 1031 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1085
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
Query: 1086 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1199
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
Query: 1200 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1243
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 293 bits (750), Expect = 1e-78
Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)
Query: 116 RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174
R RN N+ P F+ SY ATV E P GT + A D D+G G++EY +
Sbjct: 171 RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
Query: 175 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234
D SN F + +TG + + L+ E K+ + + A D RR+ TLT+ V
Sbjct: 225 DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
Query: 235 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294
D +D P+F Q LR E+ ++T ++A D D PP
Sbjct: 281 DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
Query: 295 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354
+ ILY +L G+ F + PR+ + PV+R+ + + L ++A P P
Sbjct: 321 N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
Query: 355 --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412
A + + + D+N+ +P F+ Y + E GA + LR+ A D+D
Sbjct: 379 RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
Query: 413 DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 468
+ + F + QTG L ++ P+D E + YT + A DG + +
Sbjct: 430 SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
Query: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 527
+V +QV+D NDN P F + V + G V+ + A+DAD G N + Y +
Sbjct: 487 VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
Query: 528 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
VG F IN TG I++A ++ Y+ V+A D+ PA ++ +V + + N
Sbjct: 547 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
Query: 588 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 645
N P F Q Y++ ++E VG ++ + A DR+ S ITY I +G+ + F+++ +
Sbjct: 607 N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
Query: 646 -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 703
G+++L LD + +Y+L +TASDG T+ VN VTD N + PVF + N+
Sbjct: 664 GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
Query: 704 SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 762
+ + A V + ATD D G N ++ Y + + FRI ++ G++ T +L+ E +
Sbjct: 722 N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
Query: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 822
Y L + A D + + T L I V D++DN+P F +Y V E++P T++LQI A
Sbjct: 781 YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
Query: 823 DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879
D D G N V Y + + F + +G + LR L D+E +++ A+ +
Sbjct: 841 DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
Query: 880 YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937
MPP VTV V D+ND PPVF + + V ++ G + V A D D
Sbjct: 895 DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
Query: 938 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997
+++ Y++ + P +F+++ SG + V+L+ E + LV+ A P++ S
Sbjct: 953 NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
Query: 998 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1051
ATV + +L +P + F + G +G + A I+ S+ YS
Sbjct: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
Query: 1052 GNEEDTFGINNITGVIYVNGPLD 1074
GNE +N TG + ++ LD
Sbjct: 1067 GNELSLVLLNASTGELKLSRALD 1089
Score = 292 bits (747), Expect = 2e-78
Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)
Query: 368 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 421
N +P F PSYQ + E+ P G ++ + A+D D +E T D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
Query: 422 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 479
N + S+ VT +T + +DRE + T+ F +TA D + S + I V D
Sbjct: 227 RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
Query: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535
ND+ P F + Y + ++ G V+ + A D D N I Y +L G+ G F
Sbjct: 282 TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
Query: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
I+ +G+I V+ +Y LTV+A+D R++ V++ V +N + P+F
Sbjct: 342 IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
Query: 596 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652
+ Y +++ E + GA +L + A+DR+ S + Y+I +G+ + F L TG L +
Sbjct: 401 EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
Query: 653 ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
LD E+T Y L + A DG P + V + V D+NDNAP+F P +V+E
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
Query: 711 NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 766
+ V V+A D DAG N ++ Y L + F T N G I A +L+RE D+Y
Sbjct: 520 LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
Query: 767 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
V A D ++ ++++ VLD++DN+P FT YTV + E+ GT+++ + A D D
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
Query: 827 GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
+ ++Y+I S ++ F++ +G +SL LDY+ E V A D GT
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
Query: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
A + V V D N + PVF Y V D GT + + A D D +R+ Y
Sbjct: 693 QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
Query: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1004
++D P F ++ D+G V T+ L+ E + L + A D+G P S + ++ILV
Sbjct: 751 MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 1005 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1058
+ P+F ++ Y+ V E T V ISA + +N + Y+ G++ D F
Sbjct: 806 NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
+ + +G++ LD E YVLR A + +P +V + + D N++
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
PPVF++ + V E++ + +V RV ATD D G + + Y+++ I E F ++ +
Sbjct: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
Query: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
+G + + R + + AT L +A V V ++++ D ++ N
Sbjct: 975 SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
Score = 283 bits (724), Expect = 1e-75
Identities = 266/894 (29%), Positives = 401/894 (44%), Gaps = 81/894 (9%)
Query: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 314
+P +YQA +PE N TP + R I P G L Y++ +
Sbjct: 182 QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230
Query: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 373
FF + P T ++ E ++R+ + A QD+G P A A L I + D N+ P F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 374 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---VF 430
Y+ + E+ VG + L + A D D + L S VF
Sbjct: 290 EQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340
Query: 431 TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTP 485
+ ++G+ R PVDREE ++Y ++ A D ++ P V + V D NDN P
Sbjct: 341 EIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP 397
Query: 486 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 544
F E Y V V D+ PG V+++TA D D+GSN + Y I+ G A+G F ++ TG +
Sbjct: 398 QFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALD 457
Query: 545 IAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 603
+ ++ + Y L V+A D PP + + TV + + N + P F + +
Sbjct: 458 VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQATV 514
Query: 604 SEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
E++ +G ++L++QA D + GD+ + Y + F ++ TG +++ LDRE D
Sbjct: 515 LESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD 574
Query: 661 RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQV 717
Y + A D G P T++A+V++ V DVNDN P F P + E+A V V
Sbjct: 575 FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVTV 632
Query: 718 KATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGAV 774
A D DA + GN N F ITS G + A+ L+ ++ Y L V A+DG
Sbjct: 633 SAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT- 691
Query: 775 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI 834
R T + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N
Sbjct: 692 --RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
Query: 835 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 894
+ F + TG ++ LDYE + S T + A D + ++V
Sbjct: 750 FMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 895 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFP 951
D+ND P F + Y+G V D T + + A D D GL RV Y DD
Sbjct: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD-- 861
Query: 952 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 1011
F VE SG V T L+ E + L A D G P + V + VL + P
Sbjct: 862 ---GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
Query: 1012 RFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVI 1067
+++ V E + G V ++A N I+Y IV GN + F ++ +G +
Sbjct: 919 PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978
Query: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
LDYE R YVL +QA S +V + A V++ + D N++PPV
Sbjct: 979 TALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
Score = 283 bits (723), Expect = 2e-75
Identities = 256/891 (28%), Positives = 412/891 (46%), Gaps = 106/891 (11%)
Query: 41 KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPM-NIHSIVVQVQCI 99
+G AG + T++ + + +DPV + +T LDR+ ++ + Q +
Sbjct: 210 EGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV---TTAEELDRETKSTHVFRVTAQDHGM 266
Query: 100 NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDD 159
++ + I+V D ND+ P F+ + Y ++ E VG + T ATD D
Sbjct: 267 PRRSALAT---LTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLT-----VRATDGDA 318
Query: 160 GPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
PN I Y +++ + P ++ FEI +G I R ++ E+ Y + ++A+D+ ++
Sbjct: 319 PPNANILYRLLEGSGGSP--SEVFEID-PRSGVIRTRGPVDREEVESYQLTVEASDQGRD 375
Query: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
R+TT + + V D +D P F V R E++ P
Sbjct: 376 PGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR-----------------EDVTPGAP 417
Query: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
+ A D+D+ + YSI+ G F++ +T L ++ P++ + ++
Sbjct: 418 VLRVTASDRDK-----GSNAVVHYSIMSGNARGQ---FYLDAQTGALDVVSPLDYETTKE 469
Query: 339 FDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
+ L ++A+ PL +GL +++LD N+ +P F +Q +LES P+G +
Sbjct: 470 YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV----- 524
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
L + A+D D D E L + FT+ T ++++ +DREE Y+F
Sbjct: 525 ----LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TGWISVAAELDREEVDFYSF 578
Query: 458 SITAFDGVQESEPVI-----VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 512
+ A D P + V++ V+D NDN PTF + Y V + D G SV+ ++AV
Sbjct: 579 GVEARD---HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAV 635
Query: 513 DADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAPP 569
D D ++ ITY+I G + F I + GL+++A ++ + R Y L V A+D
Sbjct: 636 DRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT-- 691
Query: 570 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSI 626
R + + V N P F Y++ ++E G ++ + ATD E I
Sbjct: 692 ---RQDTAQIVVNVTDANTHRPV-FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARI 747
Query: 627 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVV 685
TY +E+ PQ F + TG +T LD E Y L ITA D G P + T + I+V
Sbjct: 748 TYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 686 TDVNDNAPVF--DPYLPRNLSVVEEEANAF--VGQVKATDPDAGINGQVHYSL-----GN 736
DVNDNAP F D Y V E+ F V Q+ ATD D+G+NG+V Y+ G+
Sbjct: 806 NDVNDNAPQFLRDSY----QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
Query: 737 FNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 796
+ + TS G + T +L+RE Y L A D + P + + + + VLD++DN PV
Sbjct: 862 GDFIVESTS-GIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV 920
Query: 797 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854
F + V VEEN P G + ++ A D D G N + Y+I + F L F+GEL+
Sbjct: 921 FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
Query: 855 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPV 903
L LDYE P+ I T P ++ TV V+ D ND PPV
Sbjct: 981 LVDLDYEDRPEY---------VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
Score = 231 bits (588), Expect = 7e-60
Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDN+P F + Y V E G + A+D D G N + Y I
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
+ F + TG + + L+YE Y + ++A D + + +T
Sbjct: 440 SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
V VLD +D P+F+ + PL Y + +QAID D
Sbjct: 493 VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
D + Y L G D+P F ++ T +S+ ++R+ + ++A +D+G
Sbjct: 536 -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
Query: 351 HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
P L A A + + +LD N+ +P FT P Y + E A VG TS + + A+D+
Sbjct: 587 TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
Query: 410 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469
D + + + F++T ++L P+D + ++ Y ++TA DG ++
Sbjct: 638 DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
Query: 470 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529
IV + V DAN + P F Y V V D G +V+ ++A D D G N ITY +
Sbjct: 696 AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
Query: 530 AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 588
+ F I+ TG +T ++ +Y L + A DN P + T Y+E+L + N
Sbjct: 754 SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
Query: 589 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 644
+ P+F + Y + E + +L + ATDR+ + Y + GD F + T
Sbjct: 810 DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
Query: 645 TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 703
+GI+ + LDRE+ +Y+L A D G P + V + V DVNDN PVF+
Sbjct: 870 SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
Query: 704 SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 757
V EE + V +V ATDPD G N Q+ Y + GN +F++ +G + V L+
Sbjct: 927 DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
Query: 758 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 812
E R Y LV+ AT P S T+ +++LD +DN PV N + Y + P
Sbjct: 987 EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
Query: 813 GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
G I ++ A D D+ +++Y L+ TGEL L R+LD
Sbjct: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 140 bits (354), Expect = 9e-33
Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDN+PTF Y +NE VGT++ T + D A VI
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
Query: 171 YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Y + + F I G +V L L+Y+ + +Y + + A+D R T +
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
V+V D + P+F N + RP + I A D+D
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ I Y + P+ F + T ++ ++ + + L I A +DN
Sbjct: 742 G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
Query: 350 GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
G P + L I + D N+ +P F SYQG + E P TS L+I A D
Sbjct: 791 GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
Query: 409 KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 464
+D + F +D F V T GI R L L DRE Y A D G
Sbjct: 842 RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
Query: 465 VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523
+ + P+ V + V+D NDN P F + +DV+V + G +V ++TA D DEG+N +I
Sbjct: 898 MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
Query: 524 YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Y+I+ G + F ++ +G +T ++ Y L +QA +AP R TV++
Sbjct: 958 YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
Query: 583 VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 638
+L N+ P F L + + + G + + A D + DS+TY+ E G+ +
Sbjct: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
Query: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 687
L+ +TG L L +ALD I+ + SDG T+ + + ++TD
Sbjct: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
Score = 88.6 bits (218), Expect = 5e-17
Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
++ + V D N + P F+ Y VNE P GTT+ ATD D G N +I Y +
Sbjct: 697 QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ S F I TG + + L+YED+ Y + I A D N +++ TT L
Sbjct: 752 E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
+ V D +D P FL RD +YQ ++ E++ P I A D+D
Sbjct: 802 EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ + Y+ G +D F + + + L ++R+ ++ L A
Sbjct: 845 GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
Query: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
P + + +LD N+ P F + ++ E++P+G ++ R+ A D
Sbjct: 898 MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
Query: 410 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469
D + + VF + + LT L +D E++ Y I A S
Sbjct: 949 DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
Query: 470 PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 525
V+++++D NDN P EI ++ YV + PG ++ ++ A D D + +TY
Sbjct: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
Query: 526 ILVGAQGDFI-INKTTGLITIAPGVE 550
G + + +N +TG + ++ ++
Sbjct: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 291 bits (746), Expect = 3e-78
Identities = 301/1092 (27%), Positives = 473/1092 (43%), Gaps = 134/1092 (12%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
+ V D ND +PTF+ + Y + E P GT++ T ATD D G NGQ+ Y
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLT-----LRATDPDVGANGQVTY----- 1686
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
S+++F + TG + + L+ E++ + + A DR + + T T+ V
Sbjct: 1687 --GGVSSESFSLDPD-TGVLTTLRALDREEQEEINLTVYAQDRG---SPPQLTHVTVRVA 1740
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
V D +D P F L +PE + P+ L + + P D N Q
Sbjct: 1741 VEDENDHAPTFGSAHL------------SLEVPEGQDPQTLTMLRASDP----DVGANGQ 1784
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
+ Y IL G P F + + E + P++R+ F L I+A +D G P
Sbjct: 1785 -------LQYRILDGDPSGA---FVLDLASGEFGTMRPLDREVEPAFQLRIEA-RDGGQP 1833
Query: 353 -LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
L A L + +LD N+ +P F +P+Y + E P G + L++ A D D
Sbjct: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLL---------LQLQAHDPDA 1884
Query: 412 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE---S 468
+L + +G R L DRE+ +YTFS++A DG S
Sbjct: 1885 GANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL---DREQCPSYTFSVSAVDGAAAGPLS 1941
Query: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS-------VIQLTAVDADEGSNGE 521
V V I V D ND+ PTFP + + RPG S + L A D D G+N
Sbjct: 1942 TTVSVTITVRDVNDHAPTFPTSPLRLRL---PRPGPSFSTPTLALATLRAEDRDAGANAS 1998
Query: 522 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
I Y + ++ TG I +A + R L + A D PA S V I
Sbjct: 1999 ILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPAR---SATGVII 2055
Query: 582 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS--ITYAIENGDPQRVF 639
L + PRFP+ I E G +++ +A G + ITY+I +G+ + F
Sbjct: 2056 VGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTF 2115
Query: 640 NLSETTGILTLGKA--LDRESTDRYILIITASDGRPDGTSTATV-NIVVTDVNDNAPVFD 696
++ +TG +T+ A LD E + R L++ A G G TV + + D NDNAP F
Sbjct: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG---GAFAFTVLTLTLQDANDNAPRF- 2171
Query: 697 PYLPRNLSVVEEEANAFVG---QVKATDPDAGINGQVHYSLGNFN---NLFRIT-SNGSI 749
L + E+ G QV+A D D G GQ+ YSL LF + + G+I
Sbjct: 2172 --LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229
Query: 750 YTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 809
T L+RE+ LV++ATD + TL + V+D +DN P + + V E+
Sbjct: 2230 TTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSED 2288
Query: 810 LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 869
G+ I Q+ DVD G + Y + + F++ + G +SL LD+E +
Sbjct: 2289 ALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQ 2348
Query: 870 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 929
+ + G A +TV+V+D+ND P FS+ +Y+ M+ G+ I +V A
Sbjct: 2349 LL-------AHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSAT 2401
Query: 930 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN---LNEEPTTIFKLVVVA 986
D D + Y + PA F V+ ++G + T V L + + +V+ A
Sbjct: 2402 DRDSGA--NGHISYHLAS-----PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEA 2454
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA----I 1041
D G P ++ ATV + + + P FT YR +L T++ + + A
Sbjct: 2455 RDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRS 2514
Query: 1042 NQSIVYSIVSGNEEDTFGIN--------------NITGVIYVNGPLDYETRTSYVLRVQA 1087
+ ++ YSI+SGN F + G + + PLD+E+ T Y L V A
Sbjct: 2515 HAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA 2574
Query: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
A+ P +S+ V + + D N++PPVF + Y V ED + +L V+A+
Sbjct: 2575 -------ADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 1148 DKDTGNYSVMAY 1159
D D G + ++ +
Sbjct: 2628 DADPGPHGLVRF 2639
Score = 267 bits (683), Expect = 7e-71
Identities = 287/1134 (25%), Positives = 472/1134 (41%), Gaps = 129/1134 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 169
V++ V+D N+++P F + + E G ++T + D GPN + Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP----GPNSDVRYRLL 1477
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ P P TG + + L+ E ++++A DR N + RR +
Sbjct: 1478 RQEPPVPALRLDAR-----TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSA 1532
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
V V D +D P+F A+ +R PE+ P + A D D
Sbjct: 1533 RVFVTDENDNAPVF------------------ASPSRVRLPEDQPPGPAALHVVARDPDL 1574
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ + Y + G F +H T LS++ P++R+ + L + A
Sbjct: 1575 -----GEAARVSYRLASGG----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
Query: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
P A L + + D N+++P F Y + E+ P G TS L + A D
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG---------TSLLTLRATDP 1676
Query: 410 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQE 467
D+ ++ S+ TG+ LT L+ +DREEQ+ ++ A D +
Sbjct: 1677 DVGANGQVTYGGVSSESFSL--DPDTGV---LTTLRALDREEQEEINLTVYAQDRGSPPQ 1731
Query: 468 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 527
V V + V D ND+ PTF + V P ++ L A D D G+NG++ Y IL
Sbjct: 1732 LTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL 1790
Query: 528 VG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
G G F+++ +G ++ V + L ++A D PA + TV VL
Sbjct: 1791 DGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTV--TVLDA 1848
Query: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSE 643
N+ + P FP YS+E+ E + G +LL LQA D + + +TY + G F L
Sbjct: 1849 NDHA-PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG-TAGAFLLEP 1906
Query: 644 TTGILTLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDVNDNAPVFDPYLPR 701
++G L ALDRE Y ++A DG G ++T +V I V DVND+AP F P P
Sbjct: 1907 SSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF-PTSPL 1965
Query: 702 NLSVVE-----EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--GSIYTA-- 752
L + + ++A D DAG N + Y L + G I A
Sbjct: 1966 RLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARS 2025
Query: 753 -VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
V L R L +VATD R +T + + + + P F ++ + EN P
Sbjct: 2026 PVALGPRDR---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAP 2082
Query: 812 AGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL--LRSLDYEAFPDQE 867
GT I+ A G N ++Y I S K F++ P TG +++ LD+E P
Sbjct: 2083 PGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSP--R 2139
Query: 868 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
+ E+ + +T+ ++D ND P F + Y + P+ V
Sbjct: 2140 LRLVLQAESGGAF-----AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVE 2194
Query: 928 AEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
A+D D ++ Y + Q PA +F V+ +G + T L+ E +LV++A
Sbjct: 2195 ADDLDQGS--GGQISYSLAASQ---PARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
Query: 987 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1046
D G P + SAT+ ++V+ + R T + VSE A G+ + ++ ++ V
Sbjct: 2250 TDRGSPALVGSATLTVMVIDTND-NRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPV 2308
Query: 1047 --YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
Y + +D F + G + + GPLD+E Y L++ A
Sbjct: 2309 LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----------GPHEG 2358
Query: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
A + + ++D N++ P F + Y + E +++L V ATD+D+G ++Y L P
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418
Query: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
+GF V+ G + F ++ T G SG DV++
Sbjct: 2419 -----ADGFSVDPNNGTL---------------FTIVGTVALGHDGSGAVDVVL 2452
Score = 255 bits (652), Expect = 3e-67
Identities = 299/1091 (27%), Positives = 460/1091 (42%), Gaps = 123/1091 (11%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
+ V D ND++P F +Y V E P GT + A D D G NG + Y +
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL-----QLQAHDPDAGANGHVTYYLGAG 1897
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
T+ P +G + L+ E Y + A D A +TT ++T+
Sbjct: 1898 ----TAGAFLLEPS--SGELRTAAALDREQCPSYTFSVSAVDGAAA--GPLSTTVSVTIT 1949
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
V D +D P F PL + P P P + ++A D+D
Sbjct: 1950 VRDVNDHAPTF----------PTSPLRLRLPRPG---PSFSTPTLALATLRAEDRDAGAN 1996
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGH 351
ILY L GTP P + T E+ + PV + ++ D G
Sbjct: 1997 A-----SILYR-LAGTP---PPGTTVDSYTGEIRVARSPVALGPRDRVLFIVAT--DLGR 2045
Query: 352 PLPAFAGLHIEILD-ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
P + G+ I L E + P F S + I E+AP G I SP + A
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI------VSPRAVHA---- 2095
Query: 411 IEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 469
T P + L+ + F++ + + + +D E + A G +
Sbjct: 2096 -GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAF 2154
Query: 470 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529
V+ + + DANDN P F Y ++ ++Q+ A D D+GS G+I+Y +
Sbjct: 2155 TVLT-LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAAS 2213
Query: 530 --AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
A+G F ++ TTG IT ++ + L + A D PA ++ TV +
Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI---DT 2270
Query: 588 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTG 646
N + P PQ + L +SE +G+ + + D + G + Y + PQ F++ G
Sbjct: 2271 NDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG 2329
Query: 647 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 706
++L LD E DRY L + A DG +G + TV +V DVNDNAP F L + + +
Sbjct: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV--LVEDVNDNAPAFSQSLYQVMLLE 2387
Query: 707 EEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT---AVKLNREVRDY 762
+ + V ATD D+G NG + Y L + + F + +NG+++T V L +
Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447
Query: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 822
++V+ A D R + T+ +++ D +D++P FT S Y V V E+LP G+T+L +EA
Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
Query: 823 DVDLG---ANVSYRIRSPEVKHFFALHPFTGE--------------LSLLRSLDYEAFPD 865
D D A V Y I S F L P E L LL LD+E+
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
Query: 866 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 925
++ A D + VTV V D+ND PPVF++ Y+ V D G +
Sbjct: 2568 YNLTVA----AADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623
Query: 926 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 985
V A DADP P VR+ V P+ +FE++E SG + L+ E +LVV
Sbjct: 2624 VEASDADPG--PHGLVRFTVSSGD---PSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
Query: 986 AFDD-GEPVMSSSATVKILVLH------PGEIPRFTQEEYRPPPVSELATKGTMVGVISA 1038
A D G + T+++ ++ P + + E +PP GT+V + A
Sbjct: 2679 AADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP--------GTLVTTLHA 2730
Query: 1039 ----AAINQSIVYSIVSGNE----EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1090
A + YS++ + F +N+ TG + P DYE S+ L V A
Sbjct: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
Query: 1091 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
NL S S T V + +DE + PVF + V E AR S+ V+ATD+D
Sbjct: 2791 ----GNL---SASVTVSVLVTGEDE--YDPVFLAPAFHFQVPEGARRGHSLGHVQATDED 2841
Query: 1151 TGNYSVMAYRL 1161
G ++ Y L
Sbjct: 2842 GGADGLVLYSL 2852
Score = 254 bits (649), Expect = 6e-67
Identities = 314/1199 (26%), Positives = 497/1199 (41%), Gaps = 141/1199 (11%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
+T R LDR+ I+ V + + VR+ V D ND++PTF V
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761
Query: 136 E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 194
E P T+ A+D D G NGQ++Y I D + F + L +G
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL----DGDPSGAFVLDLA-SGEFGT 1809
Query: 195 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF-LPCVLVPNTR 253
+ L+ E + + + I+A D Q + T LTV VLD +D P F +P V
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ---PALSATLLLTVTVLDANDHAPAFPVPAYSV---- 1862
Query: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
PE++ + +QA D D + Y + GT
Sbjct: 1863 --------------EVPEDVPAGTLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA-- 1901
Query: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPY 372
F + P + EL ++R+ + + A + PL + I + D N+ +P
Sbjct: 1902 --FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959
Query: 373 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD--------PELHLFLN 424
F + + P +T + +L + LR A D+D P ++
Sbjct: 1960 FPTSPLRLRLPRPGPSFSTPTLAL---ATLR--AEDRDAGANASILYRLAGTPPPGTTVD 2014
Query: 425 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 484
YT V ++ + L P DR T S ++ + + +
Sbjct: 2015 SYTGEIRVARSPVA-----LGPRDR----VLFIVATDLGRPARSATGVIIVGLQGEAERG 2065
Query: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLI 543
P FP S + + + PG ++ AV A G+NG ITY IL G + G F I +TG I
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAI 2124
Query: 544 TI--APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
T+ A G++ V L +QA A TV L N + PRF + Y
Sbjct: 2125 TVRSAEGLDFEVSPRLRLVLQAESGGAFA------FTVLTLTLQDANDNAPRFLRPHYVA 2178
Query: 602 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQR-VFNLSETTGILTLGKALDRE 657
+ E+ + LL ++A D + G I+Y++ P R +F++ TTG +T LDRE
Sbjct: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE 2238
Query: 658 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVG 715
L++ A+D G P +AT+ ++V D NDN P P L V E+ + +
Sbjct: 2239 IWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ--PWELRVSEDALLGSEIA 2296
Query: 716 QVKATDPDAG---------INGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELV 766
QV D D+G Q +S+G + +T L+ E D Y+L
Sbjct: 2297 QVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG--------PLDFEQCDRYQLQ 2348
Query: 767 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
++A DG P L + V D++DN+P F+ S Y V++ E+ P G+ IL + A D D
Sbjct: 2349 LLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405
Query: 827 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
GAN +SY + SP F++ P G L + D ++ ++EA D
Sbjct: 2406 GANGHISYHLASPA--DGFSVDPNNGTLFTIVGT-VALGHDGSGAVDVVLEARDHGAPGR 2462
Query: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
ATV V ++D ND+ P F+ Y+ V D G+ + T+ A DAD A+ V Y
Sbjct: 2463 AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA-VDYS 2521
Query: 945 VDDVQ----FPYPASIFEVEEDSGR-------VITRVNLNEEPTTIFKLVVVAFDDGEPV 993
+ F + E E +G ++ L+ E T + L V A D G+P
Sbjct: 2522 IISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPP 2581
Query: 994 MSSSATVKILVLHPGEIPR-FTQEEYRPPPVSELATKGTMVGVISAAAI---NQSIVYSI 1049
SS V + VL + P FT+ YR + ++ V ++ A + + +++
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641
Query: 1050 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN--TAK 1107
SG+ F ++ +G + + LD ET+ + L VQA P+ ++ A
Sbjct: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----------PAGAHFALAP 2691
Query: 1108 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI-IPPI 1166
V IE+QD N+H P F V+E+ T V + A D D G + + Y L+ P
Sbjct: 2692 VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPG 2751
Query: 1167 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
EG+E F + + TG ++ + F F+ V A D S VLV+ ++ D
Sbjct: 2752 PEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD 2810
Score = 250 bits (639), Expect = 8e-66
Identities = 223/768 (29%), Positives = 350/768 (45%), Gaps = 48/768 (6%)
Query: 441 LTLLQPVDREEQQTYTFSITAFDGVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYT 498
L + +DRE + Y + A+DG ++++ ++D ND+ P F + Y V
Sbjct: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266
Query: 499 DMRPGDSVIQLTAVDADEGSNGEITYEI---LVGAQGDFIINKTTGLITIAPGVEMIVGR 555
+ PG V+Q+ A DAD G NG +TYEI G F I+ TGL+ + ++ R
Sbjct: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326
Query: 556 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS-PPRFPQLMYSLEISEAMRVGAVLL 614
+ L VQA D E ++ TV++ N S F S ++SEA G ++
Sbjct: 327 VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386
Query: 615 NLQATD-REGD--SITYAIENGDPQRVFNLSETTGILTL---GKALDRESTDRYILIITA 668
+ +D +GD + ++E G+ F LS ++ L + LDRE D Y L +TA
Sbjct: 387 RISVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTA 444
Query: 669 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGI 726
+D G P + A + VTDVNDNAP FD L R + E +FV +V A DPD G
Sbjct: 445 TDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504
Query: 727 NGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 783
NGQV YSL G + F I ++G I TA L+ E+ +L+VVATDG + P S+ T+
Sbjct: 505 NGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564
Query: 784 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRS---PE 838
++ + D++DN P F + Y + E GT LQ+ A D D G +SY + +
Sbjct: 565 SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624
Query: 839 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
F + +G++ R+LD + P +S F V A D G + V V + D N
Sbjct: 625 GSPPFRIDAHSGDVCTTRTLDRDQGP---SSFDFTVTAVD--GGGLKSMVYVKVFLSDEN 679
Query: 899 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 958
D PP F R Y ++ + GT + + A D D R+ Y + P +F
Sbjct: 680 DNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS--HGRLSYHILAGNSP---PLFT 734
Query: 959 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1018
++E SG + L ++ +L + A D G SA V I ++ P ++
Sbjct: 735 LDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQ 794
Query: 1019 RPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1075
V E GT VG++ A + S+ G+ F ++ ++G++ PLD
Sbjct: 795 YVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854
Query: 1076 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1135
E VL ++ V A VP A+V + + D N++ P F + +
Sbjct: 855 EL-LGPVLELE------VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNT 907
Query: 1136 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1183
T + ++A D D+G S + + L + G F V+ TG ++
Sbjct: 908 APGTPIYTLRALDPDSGVNSRVTFTL----LAGGGGAFTVDPTTGHVR 951
Score = 247 bits (631), Expect = 7e-65
Identities = 290/1154 (25%), Positives = 475/1154 (41%), Gaps = 113/1154 (9%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
EV + V D ND++P F V E T GT A D D G G Y +
Sbjct: 128 EVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPL-----EPARDADAGRLGTQGYAL 182
Query: 170 Q-------YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
+ + D +P +V+ L+ E+++ Y + ++A D +
Sbjct: 183 SGDGAGETFRLETRPGPDGTPVP-----ELVVTGELDRENRSHYMLQLEAYDGG---SPP 234
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
R L V +LD +D P F Y A + E P +P++ +
Sbjct: 235 RRAQALLDVTLLDINDHAPAF------------NQSRYHAVVSESLAPG--SPVL---QV 277
Query: 283 QAIDQDRNIQPPSDRPGILYSILVGTPE-DYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
A D D + + Y I E D P F + T L L P++ + + +L
Sbjct: 278 FASDADAGVNG-----AVTYEINRRQSEGDGP--FSIDAHTGLLQLERPLDFEQRRVHEL 330
Query: 342 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG----YILESAPVGATISDSLN 397
V++A HP A + + + D N+ P T+ + E+AP G ++
Sbjct: 331 VVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA---- 386
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYT 456
RI D D D +++ L F + TQ + + + + +DREE+ Y
Sbjct: 387 -----RISVSDPD--DGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYN 439
Query: 457 FSITAFDGVQ---ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR-PGDSVIQLTAV 512
+TA D +E V + V D NDN P F Y ++ PG V+++TA
Sbjct: 440 LRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTAR 498
Query: 513 DADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 571
D D+G+NG++TY + GA F I+ T+G+IT A ++ + L V A D P
Sbjct: 499 DPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPL 558
Query: 572 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITY 628
++ +V ++ + N + P+F + Y+ + E + G L + ATD + ++Y
Sbjct: 559 ASSATVSVALQDV---NDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSY 615
Query: 629 AI-----ENGDPQRVFNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVN 682
++ +G P F + +G + + LDR+ + +TA DG S V
Sbjct: 616 SLGAGLGSSGSPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG-GLKSMVYVK 672
Query: 683 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 740
+ ++D NDN P F P + V +++A DPD G +G++ Y + GN L
Sbjct: 673 VFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPL 732
Query: 741 FRITSNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
F + + T A L R +L + A DG + + I ++ P+F
Sbjct: 733 FTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQ 792
Query: 800 STYTVLVEENLPAGTTILQIEAKDVDLG-ANVSYRIRSPEVKHFFALHPFTGELSLLRSL 858
Y V E++ GT++ ++A + A V+ + + + F+L +G L LR L
Sbjct: 793 LQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPL 852
Query: 859 DYEAF-PDQEASITFLVEAFDIYGTMPPG--IATVTVIVKDMNDYPPVFSKRIYKGMVAP 915
D E P E + +PP +A V V++ D+ND P F ++ P
Sbjct: 853 DRELLGPVLELEVR-------AGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPP 905
Query: 916 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
+ GTPI T+ A D D S V RV F V+ +G V L
Sbjct: 906 NTAPGTPIYTLRALDPD------SGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPS 959
Query: 976 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTM 1032
+L + A D G P +S ++++V G PRF YR S T GT
Sbjct: 960 GGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSG-TTAGTQ 1018
Query: 1033 VGVISAAAINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1091
V + A A + I Y + + FG+ +G ++V LD E + Y+L+V A
Sbjct: 1019 VLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA---- 1074
Query: 1092 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
V + + ++ TA V + I ++N H P + V+E+ TSV RV ATD+D+
Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134
Query: 1152 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
G + Y L + E + F + TG + T ++S ++ V D S
Sbjct: 1135 GPNGRLTYSL--QQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRS 1192
Query: 1212 GKADVLVSVVNQLD 1225
V V+V++ D
Sbjct: 1193 TTGTVHVAVLDLND 1206
Score = 242 bits (617), Expect = 3e-63
Identities = 295/1132 (26%), Positives = 486/1132 (42%), Gaps = 143/1132 (12%)
Query: 108 YHEVRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
+ +R+VV+D +P F +Y + T GT + A D GP
Sbjct: 981 HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL-----QVQAQAPDGGP---- 1031
Query: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
I Y+ ++ F + +G + +R L+ E + Y + + A ++ ++T
Sbjct: 1032 ---ITYHLAAEGASSPFGLEPQ-SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTG 1087
Query: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
T T+ V +L+ ++ P R T+ L E P + A
Sbjct: 1088 TATVRVSILNQNEHSP-----------RLSEDPTF------LAVAENQPPGTSVGRVFAT 1130
Query: 286 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 345
D+D P+ R + YS L ED + F +HP+T E++ L+ ++R+ + L+++
Sbjct: 1131 DRDSG---PNGR--LTYS-LQQLSED-SKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQV 1183
Query: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
+ P +H+ +LD N+ SP F S +A G I + +
Sbjct: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQAS------GAAGGGLPIQVPDRVPPGTLVT 1237
Query: 406 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY--------LTLLQPVDREEQQTYTF 457
L KDP+ + T ++T+T G + L P+ R E+ Y
Sbjct: 1238 TLQ-----AKDPDEG---ENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289
Query: 458 SITAFDGVQESEPVIVNIQVM--------------DANDNTPTFP-EISYDVYVYTDMRP 502
+++A D Q S P ++Q++ D + P P + V +RP
Sbjct: 1290 TLSAHD--QGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
Query: 503 GDSVIQLTAVDADEGSNGEITYEILVGA--QGDFIINKTTGLITIAPGVEMIVGRTY-AL 559
G + + A + G +TY ++ GA +G F ++ +G + +A ++ G + AL
Sbjct: 1348 GSLLGSVAA--PEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRAL 1405
Query: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
TV+A R + V ++V N+ P F + +L + E GA L +A+
Sbjct: 1406 TVRAEGPGGAGAR---LLRVQVQV-QDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
Query: 620 DREG----DSITYAIENGDPQ-RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 674
D +G + Y + +P L TG L+ + LDRE+T +L++ A+D RP
Sbjct: 1462 DADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD-RPA 1520
Query: 675 GTST-----ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG-QVKATDPDAGING 728
S + + VTD NDNAPVF P + + E++ V A DPD G
Sbjct: 1521 NASRRRAARVSARVFVTDENDNAPVFAS--PSRVRLPEDQPPGPAALHVVARDPDLGEAA 1578
Query: 729 QVHYSLGNFNN-LFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
+V Y L + + FR+ +S G++ L+RE R + L VVA+D PR +T L +
Sbjct: 1579 RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
Query: 787 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 844
V D++D +P F Y+VL+ EN P GT++L + A D D+GAN V+Y S E F+
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFS 1695
Query: 845 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPP 902
L P TG L+ LR+LD E ++ I V A D PP + TV V V+D ND+ P
Sbjct: 1696 LDPDTGVLTTLRALDRE----EQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAP 1749
Query: 903 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 962
F + + P+ +T + A D D +++YR+ D P+ F ++
Sbjct: 1750 TFGS-AHLSLEVPEGQDPQTLTMLRASDPDVGA--NGQLQYRILDGD---PSGAFVLDLA 1803
Query: 963 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPP 1021
SG T L+ E F+L + A D G+P +S++ + + VL + P F Y
Sbjct: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY-SV 1862
Query: 1022 PVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1077
V E GT++ + A A N + Y + +G F + +G + LD E
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQ 1921
Query: 1078 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1137
SY V A + S T V I ++D N+H P F +
Sbjct: 1922 CPSYTFSVSA------VDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPS 1975
Query: 1138 FT----SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1185
F+ ++ ++A D+D G + + YRL P G V++YTG I+ A
Sbjct: 1976 FSTPTLALATLRAEDRDAGANASILYRLAGTP----PPGTTVDSYTGEIRVA 2023
Score = 237 bits (604), Expect = 9e-62
Identities = 257/1049 (24%), Positives = 439/1049 (41%), Gaps = 132/1049 (12%)
Query: 89 IHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 146
+H +VVQ + + ++G+ V + VRD NDN P+ T IF
Sbjct: 327 VHELVVQARDGGAHPELGSAF---VTVHVRDANDNQPSM----------------TVIF- 366
Query: 147 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN--------------- 191
S D + P GQ+ V + + DP D + + L G
Sbjct: 367 -LSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
Query: 192 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 251
+ + +RL+ E++ Y + + A D + + V D +D P F
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSG---SPPLRAEAAFVLHVTDVNDNAPAF-------- 472
Query: 252 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 311
R L +PE+ P +V + DQ N Q + YS+ G
Sbjct: 473 ---DRQLYRPEPLPEVALP---GSFVVRVTARDPDQGTNGQ-------VTYSLAPGA--- 516
Query: 312 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 371
+ +F + P + ++ ++ + + L++ A PL + A + + + D N+ P
Sbjct: 517 HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEP 576
Query: 372 YFTMPSYQGYILESAPVGA-----TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 426
F Y + E G T +D+ + L +L + + P + + +
Sbjct: 577 QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI--DAH 634
Query: 427 TSVFTVTQTGITRYLTLLQPVDREE-QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 485
+ T+T +DR++ ++ F++TA DG V V + + D NDN P
Sbjct: 635 SGDVCTTRT-----------LDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
Query: 486 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT 544
F Y + PG +V++L A D D+GS+G ++Y IL G F +++ +GL+T
Sbjct: 684 QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Query: 545 IAPGVEMIVGRTYALTVQAAD----NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 600
+A + L + A D A P+ R V I ++ P +PP F QL Y
Sbjct: 744 VAWPLARRANSVVQLEIGAEDGGGLQAEPSAR------VDISIV-PGTPTPPIFEQLQYV 796
Query: 601 LEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
+ E + G + +QA + G +T ++ GDP+ +F+L +G+L + LDRE
Sbjct: 797 FSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDREL 856
Query: 659 TDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 717
+ L + A G P + A V +++ DVNDN+P F L + +
Sbjct: 857 LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916
Query: 718 KATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVH 775
+A DPD+G+N +V ++L G + G + L +EL + A DG
Sbjct: 917 RALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976
Query: 776 PRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 833
PR S L + V D+ +P F + TY V + AGT +LQ++A+ D G ++Y
Sbjct: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYH 1035
Query: 834 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGT-----MPPGIA 888
+ + F L P +G L + +L D+EA ++++ + G+ G A
Sbjct: 1036 LAAEGASSPFGLEPQSGWLWVRAAL------DREAQELYILKVMAVSGSKAELGQQTGTA 1089
Query: 889 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 948
TV V + + N++ P S+ VA + GT + V+A D D P R+ Y +
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQ-- 1145
Query: 949 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 1008
Q + F + +G V T L+ E + ++L+V D G P S++ TV + VL
Sbjct: 1146 QLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLN 1205
Query: 1009 E-IPRFTQEEYR-----PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1058
+ P F Q P V + GT+V + A N +I+Y++ +G + F
Sbjct: 1206 DNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSELF 1264
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQA 1087
++ +G + PL R YVL + A
Sbjct: 1265 SLHPHSGELLTAAPLIRAERPHYVLTLSA 1293
Score = 226 bits (577), Expect = 1e-58
Identities = 271/1006 (26%), Positives = 431/1006 (42%), Gaps = 128/1006 (12%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V I VRD ND++PTF + P +T + A D D G N I Y +
Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLA 2004
Query: 171 YNPDDPTSNDTFEIPLMLTGNI-VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
P T+ D++ TG I V R + + R I+ A +L + T +
Sbjct: 2005 GTPPPGTTVDSY------TGEIRVARSPVALGPRDRVLFIV-----ATDLGRPARSATGV 2053
Query: 230 TVDVLDGD-DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
+ L G+ + GP F P +A I E PP I
Sbjct: 2054 IIVGLQGEAERGPRF------PRASS------EATIREN-----------APPGTPIVSP 2090
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 346
R + I YSIL G + F + P T +++ DF + LV++AE
Sbjct: 2091 RAVHAGGTNGPITYSILSGNEKGT---FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147
Query: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
AF L + + D N+ +P F P Y ++ ES P L PL V
Sbjct: 2148 SGGAF---AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRP----------LEGPLLQVE 2194
Query: 407 LDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 463
D D++ ++ L +F V T T +T +DRE + A D
Sbjct: 2195 AD-DLDQGSGGQISYSLAASQPARGLFHVDPT--TGTITTTAILDREIWAETRLVLMATD 2251
Query: 464 GVQESEPVIVN-----IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
P +V + V+D NDN PT P+ +++ V D G + Q+T D D
Sbjct: 2252 ---RGSPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVD--- 2304
Query: 519 NGEITYEILV--GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 576
+G + + +L G Q F + + G +++ ++ Y L + A D P E R ++
Sbjct: 2305 SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANL 2362
Query: 577 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENG 633
TV +E + N + P F Q +Y + + E G+ +L++ ATDR+ + I+Y + +
Sbjct: 2363 -TVLVEDV---NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS- 2417
Query: 634 DPQRVFNLSETTGIL--TLGK-ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
P F++ G L +G AL + + +++ A D G P + ATV++ + D N
Sbjct: 2418 -PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476
Query: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSL--GNFNNLFRITSN 746
D+AP F R + + + ++ATD D + V YS+ GN+ +F++
Sbjct: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2536
Query: 747 ---------------GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
G + L+ E Y L V A D P+ S + + + VLD++
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596
Query: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 849
DN PVFT ++Y V V E+ P G +L +EA D D G + V + + S + F L +
Sbjct: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESS 2656
Query: 850 GELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 909
G L L +LD E +A +V+A D G +A VT+ V+D+ND+ P F +
Sbjct: 2657 GTLRLAHALDCET----QARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLL 2711
Query: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRVIT 968
VA + GT +TT++A D D R+RY + + P F + +G +
Sbjct: 2712 STSVAENQPPGTLVTTLHAIDGDAGAF--GRLRYSLLEAGPGPEGREAFALNSSTGELRA 2769
Query: 969 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELA 1027
RV + E T F+L+V A D G +S+S TV +LV E P F + V E A
Sbjct: 2770 RVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-VPEGA 2826
Query: 1028 TKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1069
+G +G + A + ++YS+ + + FGIN TG +Y+
Sbjct: 2827 RRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYL 2870
Score = 201 bits (512), Expect = 4e-51
Identities = 211/747 (28%), Positives = 328/747 (43%), Gaps = 65/747 (8%)
Query: 435 TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDV 494
+G+ R +L DRE++ Y F+ DG V V ++V D ND+ P FP+ +
Sbjct: 98 SGVVRTARVL---DREQRDRYRFTAVTPDGAT----VEVTVRVADINDHAPAFPQARAAL 150
Query: 495 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIV- 553
V G A DAD G G Y + G+ +T P E++V
Sbjct: 151 QVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVT 210
Query: 554 -------GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 606
Y L ++A D P R ++ V L N P F Q Y +SE+
Sbjct: 211 GELDRENRSHYMLQLEAYDGGSPPRRAQALLDV---TLLDINDHAPAFNQSRYHAVVSES 267
Query: 607 MRVGAVLLNLQATDRE---GDSITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDR 661
+ G+ +L + A+D + ++TY I + F++ TG+L L + LD E
Sbjct: 268 LAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRV 327
Query: 662 YILIITASDG--RPDGTSTATVNIVVTDVNDNAPVFDP-YLPRNLSVVEEEA---NAFVG 715
+ L++ A DG P+ +A V + V D NDN P +L + S EA V
Sbjct: 328 HELVVQARDGGAHPE-LGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386
Query: 716 QVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIY----TAVKLNREVRDYYELVVVATD 771
++ +DPD G V+ SL F +++ S+ A +L+RE RD Y L V ATD
Sbjct: 387 RISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446
Query: 772 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY--TVLVEENLPAGTTILQIEAKDVDLGAN 829
P + + V D++DN+P F Y L E LP G+ ++++ A+D D G N
Sbjct: 447 SGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP-GSFVVRVTARDPDQGTN 505
Query: 830 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP-- 885
V+Y + H+F++ P +G ++ SLDYE P + +V A D G +PP
Sbjct: 506 GQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQ----LIVVATD--GGLPPLA 559
Query: 886 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 945
ATV+V ++D+ND P F + Y + GT V A DAD P + Y +
Sbjct: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG--PFGLLSYSL 617
Query: 946 DDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1004
+ F ++ SG V T L+ ++ + F V A D G + S VK+ +
Sbjct: 618 GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFL 675
Query: 1005 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFG 1059
+ P+F EY +S + GT V + A +Q + Y I++GN F
Sbjct: 676 SDENDNPPQFYPREY-AASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFT 734
Query: 1060 INNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1119
++ +G++ V PL + L + A+ + A PS A+V I I P
Sbjct: 735 LDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAE---PS----ARVDISIVPGTPTP 787
Query: 1120 PVFQKKFYIGGVSEDARMFTSVLRVKA 1146
P+F++ Y+ V ED TSV V+A
Sbjct: 788 PIFEQLQYVFSVPEDVAPGTSVGIVQA 814
Score = 200 bits (509), Expect = 1e-50
Identities = 189/620 (30%), Positives = 279/620 (45%), Gaps = 68/620 (10%)
Query: 641 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLP 700
+ E +G++ + LDRE DRY DG +T V + V D+ND+AP F P
Sbjct: 94 IDEHSGVVRTARVLDREQRDRYRFTAVTPDG-----ATVEVTVRVADINDHAPAF-PQAR 147
Query: 701 RNLSVVEEEANAFVGQVK-ATDPDAGINGQVHYSLGN--FNNLFRI-TSNGSIYTAV--- 753
L V E A ++ A D DAG G Y+L FR+ T G T V
Sbjct: 148 AALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPEL 207
Query: 754 ----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 809
+L+RE R +Y L + A DG PR + L + +LDI+D++P F S Y +V E+
Sbjct: 208 VVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSES 267
Query: 810 LPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEAFPD 865
L G+ +LQ+ A D D G N V+Y I R E F++ TG L L R LD+E
Sbjct: 268 LAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFE---- 323
Query: 866 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 925
Q +V+A D G A VTV V+D ND P + V + G+P
Sbjct: 324 QRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMT-------VIFLSADGSP--- 373
Query: 926 VYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVITRVN----------LNE 974
+A PPG +R+ DD F + E E + T+ + L+
Sbjct: 374 -QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDR 432
Query: 975 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1030
E + L V A D G P + + A VLH ++ P F ++ YRP P+ E+A G
Sbjct: 433 EERDAYNLRVTATDSGSPPLRAEAA---FVLHVTDVNDNAPAFDRQLYRPEPLPEVALPG 489
Query: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1086
+ V ++A N + YS+ G F I+ +G+I LDYE
Sbjct: 490 SFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ------ 543
Query: 1087 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1146
L VV + +P +++A V + +QD N++ P FQ+ FY + E + T L+V A
Sbjct: 544 -PQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTA 602
Query: 1147 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFKFQVIATDD 1205
TD D+G + +++Y L G F ++ ++G + T L + S F F V A D
Sbjct: 603 TDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD- 661
Query: 1206 YGKGLSGKADVLVSVVNQLD 1225
G GL V V + ++ D
Sbjct: 662 -GGGLKSMVYVKVFLSDEND 680
Score = 84.0 bits (206), Expect = 1e-15
Identities = 112/464 (24%), Positives = 189/464 (40%), Gaps = 79/464 (17%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 167
V + ++D+ND++P+F Y V E P G+T+ T ATD D + ++Y
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522
Query: 168 -------VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 220
V Q P + ++ G +VL + L++E T+Y + + A DR Q
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ--- 2579
Query: 221 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 280
+++ +TV VLD +D P+F TR +Y+ +PE TP + V
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVF--------TR----ASYRVTVPE-DTPVGAELLHV-- 2624
Query: 281 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 340
+A D D P + +++ G P F + + L L ++ + +
Sbjct: 2625 --EASDAD-----PGPHGLVRFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQ 2674
Query: 341 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
LV++A G A A + IE+ D N+ P F + + E+ P G ++
Sbjct: 2675 LVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT------ 2727
Query: 401 PLRIVALDKD-----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 449
+ A+D D +E PE F + + T L P D
Sbjct: 2728 ---LHAIDGDAGAFGRLRYSLLEAGPGPEGR-------EAFALNSS--TGELRARVPFDY 2775
Query: 450 EEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 509
E +++ + A D S V V++ V ++ P F ++ V R G S+ +
Sbjct: 2776 EHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHV 2835
Query: 510 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI-----APG 548
A D D G++G + Y L + F IN+TTG + + APG
Sbjct: 2836 QATDEDGGADGLVLYS-LATSSPYFGINQTTGALYLRVDSRAPG 2878
Score = 52.0 bits (123), Expect = 6e-06
Identities = 68/290 (23%), Positives = 106/290 (36%), Gaps = 45/290 (15%)
Query: 959 VEEDSGRVITRVNLNEEPTTIFKLVVVAFD--------------DGEPVMSSSATVKILV 1004
++E SG V T L+ E ++ V D D P + +
Sbjct: 94 IDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVP 153
Query: 1005 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1064
H R+ E R L T+G Y++ +TF +
Sbjct: 154 EHTAFGTRYPLEPARDADAGRLGTQG----------------YALSGDGAGETFRLETRP 197
Query: 1065 GV-------IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1117
G + V G LD E R+ Y+L+++A + P + A + + + D N+
Sbjct: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEA-------YDGGSPPRRAQALLDVTLLDIND 250
Query: 1118 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
H P F + Y VSE + VL+V A+D D G + Y I EG F ++
Sbjct: 251 HAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE-INRRQSEGDGPFSIDA 309
Query: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1227
+TGL++ +R + V A D G A V V V + D Q
Sbjct: 310 HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQ 359
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 290 bits (743), Expect = 7e-78
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 106 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
Query: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Query: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
Query: 286 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
Query: 345 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
Query: 401 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 455
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
Query: 456 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
Query: 515 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
Query: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
Query: 632 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 685
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
Query: 686 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 739
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
Query: 740 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 796
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 797 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
Query: 855 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 909
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
Query: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
Query: 970 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1028
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
Query: 1029 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
Query: 1086 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
Query: 1145 KATDKDTGNYSVMAYRLI 1162
KATD D G + + YR++
Sbjct: 1125 KATDADEGEFGRVWYRIL 1142
Score = 284 bits (727), Expect = 5e-76
Identities = 345/1337 (25%), Positives = 584/1337 (43%), Gaps = 155/1337 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF-----DLVIKA 345
I ++ L+G F ++ T +++ V D + F +L++ A
Sbjct: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIID-REAFSPPILELLLLA 2043
Query: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
E D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++
Sbjct: 2044 E-DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVT 2092
Query: 406 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 464
A D+D + + TG+ R +DREEQ++Y ++ A D
Sbjct: 2093 ATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRG 2150
Query: 465 -VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523
V S IV I + D ND+ P F V V PG + +TA+D D N ++
Sbjct: 2151 TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLE 2208
Query: 524 YEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA- 570
Y I LV Q D F +N TG + + + + TY +T+ DNA
Sbjct: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268
Query: 571 ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---G 623
ER S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328
Query: 624 DSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 681
+TY + + P L +++ G + + +D E + ASD G P + V
Sbjct: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388
Query: 682 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 741
+ + D+NDN P+FD + + + V ATD D+G + YSLG+ + F
Sbjct: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF 2448
Query: 742 RIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPV 796
I + G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P
Sbjct: 2449 AINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508
Query: 797 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854
F+ ++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTT 2567
Query: 855 LRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKG 911
R L YE F + V A D G PP G + V V D+ND PVF +
Sbjct: 2568 QRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGT 2618
Query: 912 M--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
+ + + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 2619 ILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
Query: 970 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPP 1022
L+ E ++ L++VA D G+PV + + L P F + +Y+
Sbjct: 2677 QRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT 2736
Query: 1023 VSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1077
V E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 2737 VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRER 2795
Query: 1078 RTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1131
+ V+A S L + + +V + ++D N+ PP F K Y GV
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855
Query: 1132 SEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIK 1183
+ DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++
Sbjct: 2856 ATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILR 2915
Query: 1184 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEK 1240
T LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 2916 TFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRG 2970
Query: 1241 KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1300
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D
Sbjct: 2971 FEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILD 3023
Query: 1301 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAF 1360
+ + + +D + F+ Y +L+++ +V + + + + A++ LA
Sbjct: 3024 VDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAI 3074
Query: 1361 IIILCCIPAILVVLVSY 1377
++ L A+L VL+++
Sbjct: 3075 LLFLA---AMLFVLMNW 3088
Score = 279 bits (714), Expect = 2e-74
Identities = 330/1231 (26%), Positives = 525/1231 (42%), Gaps = 128/1231 (10%)
Query: 41 KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCIN 100
KG G TI + N + +D + +L LN +LDR+ P+ H ++ V+
Sbjct: 265 KGRPRGIGYTI---VSGNTNSIFALDYISGVLTLNG---LLDRENPLYSHGFILTVKGTE 318
Query: 101 KK-----VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
+ I+V D NDN+P F Y + EL VG +
Sbjct: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ----VV 374
Query: 156 DIDD--GPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKR----LNYEDKTRYFVI 209
D D+ G N E + N S+ P + G +R R L+YE RY
Sbjct: 375 DKDENLGLNSMFEVYLVGN----NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
Query: 210 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 269
+ AN+ + + + +++ +D P+F +PL Y ++ E
Sbjct: 431 LFANESVPD----HVGYAKVKITLINENDNRPIF-----------SQPL-YNISLYE--- 471
Query: 270 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 329
N + T + + D + + + Y D P F + T + L+
Sbjct: 472 ----NVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLIMLIA 519
Query: 330 PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 389
++ + Q+F L I A G + I +LD N+ P F +Y G + E+ P
Sbjct: 520 RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEP-- 575
Query: 390 ATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVD 448
++T +R+ A D+D + + + S F ++ +++ +P+D
Sbjct: 576 -------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
Query: 449 REEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 504
E+ +T + P V V I+V D NDN PTF + +Y V V ++ G
Sbjct: 629 YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
Query: 505 SVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTV 561
+V+ L A D D E I Y + Q F IN +G IT ++ Y L V
Sbjct: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIV 746
Query: 562 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 621
+A D ++ I TV I +L N+ P + Y + + E + + + A D
Sbjct: 747 RAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDP 805
Query: 622 ---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILIITASD 670
E ++ Y+I+ P + ++L+ TTG I T LDRE+ D R I++
Sbjct: 806 DLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
Query: 671 GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN 727
GRP TS+ATV + + D+NDN P F LP V+E A + QV A D D G+N
Sbjct: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
Query: 728 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 784
G V Y + G F I +S+G + T +L+RE Y+L VVA+D + ST TL
Sbjct: 923 GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
Query: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 842
I VLD++D +P F + Y V V E++P ++ + D D+G N +SY I V
Sbjct: 983 IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
Query: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDY 900
F++ + + LD E A+ ++EA D G G ATV V V D+ND
Sbjct: 1043 FSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
P+F + Y+ V D +G I + A DAD RV YR + + F +
Sbjct: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNNFRIH 1153
Query: 961 EDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEY 1018
+G ++ L+ E + L+V A++ M SS V + V E P FTQ++Y
Sbjct: 1154 VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY 1213
Query: 1019 RPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
+ E A GT V V+ A + + Y I+SG E F I+ TG+I LD
Sbjct: 1214 SRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLD 1272
Query: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1134
YET+TSY++ V A + P VYI + +E + F Y + E+
Sbjct: 1273 YETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
Query: 1135 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1194
+ T ++RV+A D N + + YR + K F ++ TG+I L +
Sbjct: 1326 LALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGD 1383
Query: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
++ V+A DD G + V ++V+++ D
Sbjct: 1384 FYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
Score = 275 bits (703), Expect = 3e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 168
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
Query: 169 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
Query: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
L V +LD +D P+ P Y ++ E + ++
Sbjct: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
Query: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 342
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
Query: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
Query: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 460
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
Query: 461 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
Query: 514 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 570
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
Query: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 627
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
Query: 628 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 682
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
Query: 683 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 737
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
Query: 738 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
Query: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 850
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
Query: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 909
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
Query: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 961
V A GT I + A D D ++ Y + DD P F V
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
Query: 962 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1014
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
Query: 1015 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1067
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Query: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
Query: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
Query: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
++ ++ +A D+ G S + + V VV Q+
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Score = 274 bits (700), Expect = 7e-73
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 79 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 135
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
Query: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
Query: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
Query: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
+Y+AAI E L IV +ID I Y T
Sbjct: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
Query: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 376 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434
S I E PVG ++ + A D D L + F +
Sbjct: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
Query: 435 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 490
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
Query: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 549
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Query: 550 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 607
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
Query: 608 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 663
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
Query: 664 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
Query: 720 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 774
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
Query: 775 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 832
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
Query: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 888
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
Query: 889 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 943
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
Query: 944 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 999
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
Query: 1000 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1051
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
Query: 1052 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
Query: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1169
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
Query: 1170 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1218
++ F V TG + M +S +++AT + + A L V
Sbjct: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
Query: 1219 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1263
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Score = 223 bits (568), Expect = 1e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 368 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
Query: 426 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
Query: 484 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
Query: 544 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
Query: 602 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 659 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
Query: 711 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
Query: 759 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 818 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
Query: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
Query: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 991
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
Query: 992 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1047
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
Query: 1048 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
Query: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
Query: 1167 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1217
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
Query: 1218 VSVVNQLDMQVIVSNVP 1234
V++++ D N+P
Sbjct: 878 VNLLDLNDNDPTFQNLP 894
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/509 (24%), Positives = 205/509 (40%), Gaps = 91/509 (17%)
Query: 51 IELSLKDNVDYWVLMDPVKQMLFLNSTGR---------VLDRDPPMNIHSIVVQVQCINK 101
IE SL D + + + L+S R L +D P ++ S N+
Sbjct: 2437 IEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAS--------NR 2488
Query: 102 KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 161
+ ++ +V I V D ND P F + +V E P GT++ T ATD D+GP
Sbjct: 2489 RENSV---QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM-----ATDQDEGP 2540
Query: 162 NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 221
NG++ Y ++ + F + M +G + ++ L +K + + + A D +
Sbjct: 2541 NGELTYSLE-----GPGVEAFHVD-MDSGLVTTQRPLQSYEK--FSLTVVATDGGE---P 2589
Query: 222 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 281
TT L V+V+D +D P+F V PN I +R L +
Sbjct: 2590 PLWGTTMLLVEVIDVNDNRPVF---VRPPN----------GTILHIREEIPLRSNVYE-- 2634
Query: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
+ A D+D + + YS L FF + P + + + ++R+ + L
Sbjct: 2635 VYATDKDEGLNG-----AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
Query: 342 VIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMP---SYQGYIL---ESAPVGATIS 393
++ A D G P+P L + + D ++ P F P S Q +L E +P G +
Sbjct: 2690 ILVAS-DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
Query: 394 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453
N+T A+D D + + F + G L +L+ +DRE +
Sbjct: 2749 ---NVTG-----AVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC---LLVLRDLDREREA 2797
Query: 454 TYTFSITA---------------FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498
++F + A D V + V + + D ND P F + Y V T
Sbjct: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
Query: 499 DMRPGDSVIQLTAVDADEGSNGEITYEIL 527
D + G +IQ+ A+DAD G+N + Y IL
Sbjct: 2858 DAKVGSELIQVLALDADIGNNSLVFYSIL 2886
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 281 bits (720), Expect = 3e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 111 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 166
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
Query: 167 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Query: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
+ + G ++ N R L PE L P + I++ D
Sbjct: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
Query: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 345
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
Query: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 398
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
Query: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
Query: 459 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 512
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
Query: 513 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 571
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
Query: 572 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 628
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
Query: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 687
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
Query: 688 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 745
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
Query: 746 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 804
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
Query: 805 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 863
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
Query: 864 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
Query: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
Query: 982 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1038
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
Query: 1039 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1093
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
Query: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
Query: 1214 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1273
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
Query: 1274 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1333
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
Query: 1334 TPEAVTSIKKRGESLGYTEGALL 1356
E + I +S+ YTEGAL+
Sbjct: 1960 EYELLIQI---SDSVHYTEGALV 1979
Score = 275 bits (702), Expect = 4e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
Query: 353 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 412
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
Query: 413 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 468
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
Query: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
Query: 529 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Query: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 644
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
Query: 645 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
Query: 703 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Query: 820 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
Query: 877 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 936
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
Query: 937 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 993
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
Query: 994 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1047
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
Query: 1048 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1097
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
Query: 1098 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1157
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
Query: 1158 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1217
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Query: 1218 VSVVNQLD 1225
VSV++ D
Sbjct: 2302 VSVLDDND 2309
Score = 272 bits (696), Expect = 2e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 170
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
+ +LD +D P F+ + P E++ + I A D
Sbjct: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
Query: 291 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
Query: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
Query: 410 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
Query: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
Query: 527 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 585
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
Query: 586 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 643
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
Query: 644 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 696
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
Query: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 755
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
Query: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
Query: 816 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 872
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
Query: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
Query: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
Query: 993 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1049
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
Query: 1050 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1107
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
Query: 1108 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
Score = 257 bits (657), Expect = 7e-68
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 115 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
Query: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
Query: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 350
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
Query: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 406
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
Query: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
+ + ++ YT Q + Y + + +Q G+
Sbjct: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
Query: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
Query: 527 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 640
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
Query: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
Query: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 755
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
Query: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
Query: 816 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
Query: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
Query: 936 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 988
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
Query: 989 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1043
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
Query: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
Query: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1163
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
Query: 1164 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
P + + F+++ TG I + + + V A D K D
Sbjct: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
Query: 1219 SVVNQLDMQVI 1229
S+V +D++ I
Sbjct: 2408 SLVVWVDIEGI 2418
Score = 240 bits (612), Expect = 1e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ D L L G++ E+R T TL
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 348
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
Query: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
Query: 409 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 454
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
Query: 455 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 484
+ T +T + + V + V D NDN
Sbjct: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
Query: 485 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 539
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
Query: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
Query: 600 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 655
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
Query: 656 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
Query: 714 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 764
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
Query: 765 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
Query: 822 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
Query: 880 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
Query: 940 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
Query: 999 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1055
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
Query: 1056 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
Query: 1176 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
+ +G +KT+ RS F +A D
Sbjct: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
Score = 231 bits (590), Expect = 4e-60
Identities = 266/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 81 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 139
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
Query: 140 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 199
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
Query: 200 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 259
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
Query: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 319
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Query: 320 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 378
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
Query: 379 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 438
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
Query: 439 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
Query: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 556
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
Query: 557 YALTVQAADNAPPAERRNS-ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 615
+ + A D + R + I VY+ + N + P Q + + +S +
Sbjct: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDV---NDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
Query: 616 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 674
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
Query: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
Query: 735 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
Query: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 847
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
Query: 848 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 905
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
Query: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
Query: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
Query: 1026 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1080
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
Query: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 1141 VLRVKATDKD-TGNYSVMAYRLI 1162
++ D D T + + Y +I
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
Score = 215 bits (547), Expect = 4e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
Query: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
Query: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
Query: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
+PE +P T I D D ++ P +++S +
Sbjct: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
Query: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
Query: 376 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 434
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Query: 435 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 492
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
Query: 493 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 551
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
Query: 552 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 611
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
Query: 612 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 668
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
Query: 669 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
Query: 729 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 785
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
Query: 786 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 837
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
Query: 838 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
Query: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
Query: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1011
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
Query: 1012 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1060
+F + L T+ + + A + YSIVS + D F I
Sbjct: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
Query: 1061 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1120
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
Query: 1121 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
Score = 212 bits (540), Expect = 2e-54
Identities = 289/1117 (25%), Positives = 466/1117 (41%), Gaps = 129/1117 (11%)
Query: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHE 110
E L D +DP+ L T LDR+ + S V + I T +
Sbjct: 1514 EYFLTDEASGAFTIDPMSGTL---KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI-- 1568
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVG-TTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+++ V D NDN P + + ++ +P TT+ A D+D GPNG + +
Sbjct: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR------ADDLDLGPNGTVVFSF 1622
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQANDRAQNLNERRTTTTT 228
+ F I TG I ++ + E YF I +Q Q + R TTT
Sbjct: 1623 A------ETQSMFSID-KYTGEIQFQQNPSSE----YFPIWLQLKVTDQGIPAR--TTTG 1669
Query: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
L V ++G+D+ F + Y+ + E E IVT A
Sbjct: 1670 LLVIHMEGEDVKISFSHHL------------YKGLVTENC---EAGTSIVTVKAFA---- 1710
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 346
P S + + YSI G + + ++ +L++ EP DF + L++ AE
Sbjct: 1711 ----PDSIQDSMKYSIFSGNEDGV---LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
Query: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
+GH A+ + + I DEN+ SP F YQ + ES A + +++ A
Sbjct: 1764 S-SGHR--AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHV---------IQVFA 1811
Query: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV 465
D D E + + F + ++ +T +D E +Y+ + A D G+
Sbjct: 1812 TDLDSGLNGLIEYSILSGNQEEAFQID--ALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
Query: 466 QE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
S ++ +QV D NDN P F S V + D PG V ++ D D S ++
Sbjct: 1870 PRLSNTTVIKVQVTDINDNAPAFLP-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
Query: 525 EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
F I++ TG++ + ++ Y L +Q +D+ E + + VL
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG-----ALVVRVL 1983
Query: 585 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSE 643
N+ +PP F Q Y + + E++ VG +L L ATD E ++I+Y I + + F++
Sbjct: 1984 DVND-NPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDP 2040
Query: 644 TTG-ILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPR 701
G I T+ L ++ ++ ASDG PD + V I + D+N+ AP F
Sbjct: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSY 2099
Query: 702 NLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL--GNFNNLFRITSN-------- 746
NLS+ E+ A VG T D D N V YS+ GN N F + +
Sbjct: 2100 NLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Query: 747 ---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
G + L+RE +ELV++A+D P ST ++I+VLD++DN P F++ +Y
Sbjct: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 804 VLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 861
V+E+ P G+ I + A D D G A + Y I S K F L TG L L++ LDYE
Sbjct: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
+ T V+A D A V V V D ND+ P F + +V + +
Sbjct: 2277 ----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
Query: 922 PITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPASIFEVEEDSGRVITRVNLNEEP 976
I ++ A D D P + Y + F Y +F ++ +G + + L+ E
Sbjct: 2332 TICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN 2389
Query: 977 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY---RPPPVSELATKGTMV 1033
+ L V A D G+ S V I + E P FTQ++Y P + G +
Sbjct: 2390 GNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Query: 1034 GVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
+ A I+ I+YS+ G F +N G IY+ L S + + ++++
Sbjct: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKII 2504
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1128
+ + SK + V++ + + P VF F I
Sbjct: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
Score = 199 bits (505), Expect = 3e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 341 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
L++ A+ G A + I I F P Y + E P S
Sbjct: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
Query: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 459
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
Query: 460 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
Query: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
Query: 579 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 633
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
Query: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 690
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
Query: 691 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 746
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
Query: 747 ---GSIYTA-----------------------------------------VKLNREVRDY 762
G+IY V L+RE R +
Sbjct: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
Query: 763 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 818
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
Query: 819 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
Query: 877 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 934
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
Query: 935 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
Query: 993 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1046
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
Query: 1047 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1105
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Query: 1106 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1165
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
Query: 1166 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1223
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
Query: 1224 LD 1225
D
Sbjct: 1263 ND 1264
Score = 188 bits (477), Expect = 5e-47
Identities = 254/1092 (23%), Positives = 453/1092 (41%), Gaps = 126/1092 (11%)
Query: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
Query: 412 EDTKDPELHLFL-NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE 469
+ ++ + + + VF + + L L + EQ+ T ++ A D GV
Sbjct: 508 DSGRNGLIRYSIASPQPGVFAIDRA--LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 565
Query: 470 PVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEI 526
++V V++ +++P TF + Y V V + P ++Q A + + + Y +
Sbjct: 566 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL 625
Query: 527 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 585
F I TG I + + +TY V A +N TV + V
Sbjct: 626 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVWD 684
Query: 586 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNL 641
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F +
Sbjct: 685 ENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFKM 740
Query: 642 SETTG------ILT-------------------------------LGK-------ALDRE 657
+ TG ++T LG+ ALDRE
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 658 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEANA 712
+ + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 860
Query: 713 FVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 769
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+A
Sbjct: 861 LVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
Query: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDL 826
TD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 921 TDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHY 980
Query: 827 GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-P 885
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 981 NGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSLS 1036
Query: 886 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 945
+++ V+D ND+ P F + V + GT + A+D D L SR++Y +
Sbjct: 1037 STVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYYI 1095
Query: 946 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVKI 1002
+ + F + G ++T L+ E L V A D V S T +I
Sbjct: 1096 E--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
Query: 1003 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDT 1057
++L + P F + V E T G++V I+A N + YSI+SGNE T
Sbjct: 1154 VILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT 1211
Query: 1058 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1117
F ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N+
Sbjct: 1212 FMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVND 1264
Query: 1118 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1177
PVF++ Y V E+ V RV+A D+D+G S + + I+P E F + +
Sbjct: 1265 EAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEINS 1321
Query: 1178 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTL 1237
TG + T + + F +V+ D LS +L +V ++ D + P +
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEFI 1375
Query: 1238 VEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ--T 1295
V D+ E+L+ E + G R + ++ T T+ + + T
Sbjct: 1376 VSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELST 1432
Query: 1296 NRAIDRNELFKF 1307
RA+DR ++ F
Sbjct: 1433 TRALDREQISNF 1444
Score = 136 bits (342), Expect = 2e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 440 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 497
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
Query: 498 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 556
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
Query: 557 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 616
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
Query: 617 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
Query: 674 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 722
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
Query: 723 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 776
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
Query: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
Query: 837 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 882
FF ++P TG + + + AF E L F G
Sbjct: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
Query: 883 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 916
PP AT+ V V D+ND P F + + +
Sbjct: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
Query: 917 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 972
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
Query: 973 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1032
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
Query: 1033 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
Query: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
Query: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
D D G++ + I G F++ G + T
Sbjct: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 445 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 491
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Query: 492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 550
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Query: 551 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 609
++ ++ + ++ E + + +V + +F + + +
Sbjct: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
Query: 610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 667
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
Query: 668 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 718
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
Query: 719 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 775
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 776 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 833
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
Query: 834 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 893
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
Query: 894 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 949
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
Query: 950 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1007
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
Query: 1008 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1060
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
Query: 1061 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1088
N T G IYV + + ++VL+ V D
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 1089 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1138
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
Query: 1139 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1198
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
Query: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1252
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
Query: 1253 VQ 1254
Q
Sbjct: 977 QQ 978
Score = 112 bits (279), Expect = 5e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 508 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 561
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 562 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 612
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
Query: 613 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 669
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
Query: 670 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 714
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
Query: 715 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 769
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
Query: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 828
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
Query: 829 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 888
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
Query: 889 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 945
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
Query: 946 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1005
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Query: 1006 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1056
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
Query: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1115
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 1013 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1072
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 1073 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1128
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 1129 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1181
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
Score = 36.2 bits (82), Expect = 0.32
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 167
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 278 bits (712), Expect = 3e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 318
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 319 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 377
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 378 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 437
Y+ + E+ G I L++ A D D + I
Sbjct: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Query: 438 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 490
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 549
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Query: 550 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
Query: 609 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
Query: 666 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 724
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
Query: 725 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
Query: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
Query: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 899
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
Query: 900 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 959
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
Query: 960 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1018
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
Query: 1019 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
Query: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1132
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
Query: 1133 EDARMFTS--VLRVKATDKDTGNY 1154
+ F S + R+ A D D ++
Sbjct: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
Score = 274 bits (701), Expect = 5e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
Query: 171 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
Query: 290 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
Query: 349 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
Query: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 467
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
Query: 468 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 526 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
Query: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 639
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
Query: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 698
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
Query: 699 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 752
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
Query: 813 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
Query: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 905
+ T P ++ TV V+ D ND PV +
Sbjct: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
Score = 249 bits (637), Expect = 1e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 182
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
Query: 183 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 242
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
Query: 243 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 302
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
Query: 303 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 357
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
Query: 358 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 417
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
Query: 418 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 474
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
Query: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 533
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
Query: 534 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 592
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
Query: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 649
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
Query: 650 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
Query: 710 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 767
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
Query: 768 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
Query: 828 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
Query: 885 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
Query: 943 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Query: 1003 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1057
LV P + + G+I ++ + YS GNE
Sbjct: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
Query: 1058 FGINNITGVIYVNGPLD 1074
+N +G + ++ LD
Sbjct: 1219 LVVNQTSGELRLSRKLD 1235
Score = 246 bits (629), Expect = 1e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 368 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 425
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
Query: 426 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 481
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 482 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 535
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
Query: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
Query: 596 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
Query: 653 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
Query: 711 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 763
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
Query: 764 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
Query: 824 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
Query: 882 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 941
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
Query: 942 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Query: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1056
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
Query: 1057 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
Query: 1176 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
Score = 233 bits (595), Expect = 1e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
Query: 596 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 647
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 648 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 704
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
Query: 705 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 760 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 819 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
Query: 877 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
Query: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
Query: 996 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1051
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 1052 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1111
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
Query: 1112 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
Query: 1172 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
G F +E +G+++T S ++ A D
Sbjct: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
Score = 135 bits (339), Expect = 5e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
Query: 171 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
Query: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
Query: 408 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 463
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
Query: 464 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
Query: 523 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Query: 582 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 637
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 685
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 268 bits (685), Expect = 4e-71
Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)
Query: 373 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432
F MP+YQ + E+ P G I L L + I ++ + + Y + +
Sbjct: 245 FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 433 TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 490
T T + +DRE ++T+ + A D S + + V D ND++P F +
Sbjct: 302 TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
Query: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 550
Y V ++ G V+ + A D D N + Y +L GA F +N+++G+++ ++
Sbjct: 357 EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
Query: 551 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 610
Y L V+A D ++ TVYIEV N + P+F + Y +++ E + +
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
Query: 611 AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 667
+L +QATDR+ +I Y+I +G+ F L +GIL + LD E +Y L I
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 668 ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 724
A DG P S+ V++ V DVNDN P+F P +V+E + V ++A D D+
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
Query: 725 GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 764
G N ++HY L + + F S+G I +L+RE ++Y
Sbjct: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
Query: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824
V A D P S+ +++I VLD++DN PVFT TY + + E+ G+++L ++A+D
Sbjct: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
Query: 825 DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 882
D + ++Y++ ++ FAL G ++L LDY+ QE V A D GT
Sbjct: 715 DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
Query: 883 MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942
A V + V D N + PVF Y V+ D GT I T+ A D D +R+
Sbjct: 769 R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
Query: 943 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002
Y + D P F ++ DSG + T + L+ E + L ++A D+G P S + T++I
Sbjct: 826 YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
Query: 1003 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1056
L+L + P+F + Y+ + E A T + +SA + N ++Y+ G++ D
Sbjct: 881 LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1115
F I +GVI LD E Y +L + + P+ S + ++ + I D
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1173
N++ P+F+K V E+ + + V +++A D D G + + Y+++ EG + F
Sbjct: 993 NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
Query: 1174 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
++ G ++ + L +RR Y V+ L +A V + +V+Q D
Sbjct: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
Score = 265 bits (677), Expect = 3e-70
Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
ST VLDR+ V V Y + ++V+D ND+SP F+ Y V
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
E VG + T A+D D N + Y + + D F++ +G + R
Sbjct: 364 ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
Query: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
L+ E+ Y ++++AND+ +N + T T+ ++V D +D P F V
Sbjct: 413 AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
Query: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
++ PE++ +QA D+D+ I YSIL G
Sbjct: 466 -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
Query: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 374
F++H + L ++ P++ + QK+ L IKA+ PL +G + +++LD N+ P F
Sbjct: 507 FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
Query: 375 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434
+Q +LE+ P+G + + I A+D D ++ LH L D S F
Sbjct: 567 SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
Query: 435 T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 475
+ + ++T+ +DREE + Y+F + A D S V+I
Sbjct: 616 SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
Query: 476 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 534
V+D NDN P F + +Y++ + D G SV+ L A D D +N ITY++ G + F
Sbjct: 676 TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
Query: 535 IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592
++ + GLIT+A ++ + Y L V A+D R+ V I V N P
Sbjct: 734 ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
Query: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 649
F Y++ +SE VG + L A D E ITY I++ PQ F + +G +
Sbjct: 789 -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
Query: 650 LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
LD E+ Y L I A D G P + T T+ I++ D NDNAP F + +
Sbjct: 846 TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
Query: 709 EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 764
+ + QV ATD D+G NG++ Y+ + + ++G I T +L+RE Y
Sbjct: 906 PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
Query: 765 LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823
L +A D G+ P +++ + + +LDI+DN+P+F + VEEN P G+ + +I A D
Sbjct: 966 LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
Query: 824 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
D G N + Y+I +++HFF L G+L + LD+E +V+A
Sbjct: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
Query: 882 TMPPGI--ATVTVIVKDMNDYPPV 903
T P + ATV +++ D ND PPV
Sbjct: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
Score = 252 bits (644), Expect = 2e-66
Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)
Query: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374
+F + T +S ++R+ + L +KA + P A + + + D N+ SP F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 375 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434
Y+ + E+ VG + L I A D+D + + L VF + +
Sbjct: 355 QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
Query: 435 -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 489
+G+ +L DREE Y + A D + P+ V I+V D NDN P F E
Sbjct: 405 SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
Query: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 548
+Y V V D+ +V+++ A D D+G N I Y IL G G F ++ +G++ +
Sbjct: 462 QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
Query: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
++ + Y+L+++A D P NS V ++VL N+ + P F + + E +
Sbjct: 522 LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
Query: 609 VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 648
+G ++++QA D + D+ + + G P F + ++G +
Sbjct: 580 LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
Query: 649 TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 706
T+ LDRE + Y + A D G P +S+ +V+I V DVNDN PVF P L+
Sbjct: 640 TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
Query: 707 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 761
+ + V ++A D DA N + Y L GN N F ++S G I A+ L+ +
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
Query: 762 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821
Y L V A+DG R T + I V D + + PVF +S YTV V E+ P GT+I + A
Sbjct: 757 QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
Query: 822 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879
D D G N ++Y I+ P + F + P +G + + LDYE + + T + A D
Sbjct: 814 NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
Query: 880 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
T+ +++ D ND P F Y+G + DA T I V A D D P
Sbjct: 868 GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
Query: 940 RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 995
R+ Y DD F +E SG + T+ L+ E ++ L +A D G P +S
Sbjct: 926 RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
Query: 996 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1050
+S +++ +L + P F ++E V E G++V I A N I+Y IV
Sbjct: 981 ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
Query: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
G+ F ++ + G + LD+E R YVL VQA S +V + A V+I
Sbjct: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
Query: 1111 EIQDENNHPPV 1121
+ D+N++PPV
Sbjct: 1090 LLVDQNDNPPV 1100
Score = 226 bits (575), Expect = 2e-58
Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 134
ST VLDR+ + ++V+ + G + V I V D NDN P F ++Y V
Sbjct: 410 STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
Query: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 193
E + T + ATD D G N I Y I + N + L L+G +
Sbjct: 469 PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
Query: 194 LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 251
+ L++ED +Y + I+A D R +N ++ ++V VLD +D P+F+
Sbjct: 518 VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
Query: 252 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 308
+ PL Y P++ IQA+D D S L+ LV T
Sbjct: 574 VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
Query: 309 -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 356
P P F F +H + +++ ++R+ + + ++A P+ +
Sbjct: 611 FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
Query: 357 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416
+ I +LD N+ P FT P+Y+ + E A VG+++ L + A D+D
Sbjct: 671 TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
Query: 417 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 476
L + + F ++ +TL P+D +++Q Y ++TA DG + S V I
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
Query: 477 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 536
V DAN + P F Y V V D G S+ L+A D D G N ITY ++ F I
Sbjct: 779 VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
Query: 537 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 596
+ +G + ++ Y LT+ A DN P +++ T+ I +L N+ + P+F
Sbjct: 838 DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
Query: 597 LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 652
Y I E +L + ATDR+ + Y + GD F + T+G++ +
Sbjct: 895 DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
Query: 653 ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
LDRE+ Y L A D G P S + + + + D+NDNAP+F+ L + EE
Sbjct: 955 RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
Query: 711 N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 764
N + V +++A DPD G N Q+ Y + G+ + F++ NG + V+L+ EVR Y
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
Query: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 819
LVV AT P S T+ I ++D +DN PV + + Y + P G I I
Sbjct: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
Query: 820 EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 875
A D D+ +++Y L P TGEL L R LD EA E S++ +
Sbjct: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
Query: 876 AFDIYGTMPPGIATVTVIVKDM 897
+ + T+ VT+I DM
Sbjct: 1186 SVTAFCTL-----RVTIITDDM 1202
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 266 bits (681), Expect = 1e-70
Identities = 321/1207 (26%), Positives = 520/1207 (43%), Gaps = 141/1207 (11%)
Query: 55 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
Query: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
Query: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
Query: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
Query: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
Query: 408 DKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 465
D+D +D + +D + F + G T ++ +Q +D E QQ + + A D
Sbjct: 2298 DQDSGRNRDVSYQIVEDGSDVSKFFQI--NGSTGEMSTVQELDYEAQQHFHVKVRAMD-- 2353
Query: 466 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 520
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 2354 -KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTS 2412
Query: 521 EITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 579
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + V
Sbjct: 2413 RLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPV 2467
Query: 580 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQ 636
YI N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 2468 YINTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLAS 2526
Query: 637 RVFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPV 694
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P
Sbjct: 2527 EKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQ 2584
Query: 695 F--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA 752
F Y S V +++ V QV A D D G N V YS+ + + + +
Sbjct: 2585 FKASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGV 2642
Query: 753 VK-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 805
VK L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 2643 VKVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFS 2699
Query: 806 VEENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 862
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 2700 APEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
Query: 863 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 922
+ V A + T + +V + V D+ND PVF YK ++ + GT
Sbjct: 2760 TKLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTS 2815
Query: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
+ V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 2816 VIQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHF 2873
Query: 983 VVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA-- 1038
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 2874 HVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLD 2932
Query: 1039 ---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVV 1093
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 2933 ADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF- 2991
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 2992 ---------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDT 3042
Query: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
+ + Y L P G F ++ +TG + T R+ F ATD G G S +
Sbjct: 3043 NAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQ 3096
Query: 1214 ADVLVSV 1220
AD+ + V
Sbjct: 3097 ADITLHV 3103
Score = 266 bits (681), Expect = 1e-70
Identities = 304/1145 (26%), Positives = 493/1145 (43%), Gaps = 119/1145 (10%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
Query: 291 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
Query: 350 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
Query: 409 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
Query: 462 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
Query: 520 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
Query: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 631
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
Query: 632 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 689
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
Query: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 747
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
Query: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
Query: 808 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 866
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
Query: 867 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 925
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
Query: 926 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 985
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
Query: 986 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1040
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
Query: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1100
+N I YS++ GN+ F I+ G + V LD E +SY L+++A + P
Sbjct: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRA-------TDSGQP 3404
Query: 1101 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAY 1159
+ I++ D N++PP F + Y V E++ + + VL++ +D D+ N ++
Sbjct: 3405 PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSF 3464
Query: 1160 RLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
R I +G G T G + TA + +++ Q+ A+D LS V V
Sbjct: 3465 R-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRV 3519
Query: 1219 SVVNQ 1223
V Q
Sbjct: 3520 HVTEQ 3524
Score = 266 bits (679), Expect = 2e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 115 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 174
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
Query: 175 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 234
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
Query: 235 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 294
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
Query: 295 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 354
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
Query: 355 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
Query: 411 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 468
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
Query: 469 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 528
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
Query: 529 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
Query: 588 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 642
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
Query: 643 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 699
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
Query: 700 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 755
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
Query: 756 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 815
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
Query: 816 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
Query: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 932
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
Query: 933 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
Query: 993 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1050
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
Query: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
Query: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1163
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
Query: 1164 P 1164
P
Sbjct: 1807 P 1807
Score = 260 bits (665), Expect = 8e-69
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 91 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 150
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
Query: 151 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 210
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
Query: 211 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 270
A DR + ++E G+ G + V V P LR P
Sbjct: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
Query: 271 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 323
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
Query: 324 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 379
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
Query: 380 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 436
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
Query: 437 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 496
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 497 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 555
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
Query: 556 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 615
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Query: 616 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 671
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
Query: 672 RPDGTSTATVNIVVT--------------------------------------------- 686
+ + S T+NI V
Sbjct: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
Query: 687 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 742
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Query: 743 I-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
Query: 802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Query: 860 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
Query: 918 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 977
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
Query: 978 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1030
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
Query: 1031 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1086
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
Query: 1087 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1145
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
Query: 1146 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1203
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
Query: 1204 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
D+ L + V+V +++ D I S+
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Score = 257 bits (657), Expect = 7e-68
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 93 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 152
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
Query: 153 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 212
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
Query: 213 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 272
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
Query: 273 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 332
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
Query: 333 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 392
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
Query: 393 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 451
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
Query: 452 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 510
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
Query: 511 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 568
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
Query: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 628
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
Query: 629 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 682
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
Query: 683 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
Query: 735 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 790
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
Query: 791 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 847
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
Query: 848 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
Query: 906 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 965
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
Query: 966 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1025
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
Query: 1026 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1081
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
Query: 1082 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1141
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
Query: 1142 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1200
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
Query: 1201 IATDDYGKGLSGKADVLVSVVNQLDM 1226
++ + K S +DV +VN D+
Sbjct: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
Score = 253 bits (647), Expect = 1e-66
Identities = 323/1296 (24%), Positives = 542/1296 (41%), Gaps = 180/1296 (13%)
Query: 15 IILGSLFEICLGQYDDGTILVDNMLIKGTAGGPDP-TIELSLKDNVDY--------WVLM 65
I+ G+ E + G I + I TAG P +++++ D +Y V+
Sbjct: 601 IVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVK 660
Query: 66 DPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQ-CINKKVGTIIYHEVRIVVRDRNDNSPT 124
DP ++ VL + +H I +Q Q +++ ++ +++ N +P
Sbjct: 661 DPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQI-------NHYTPQ 713
Query: 125 FK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFE 183
F+ H V E P+ T + ATD D G NG++ YVI D F+
Sbjct: 714 FEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGNEEGCFD 764
Query: 184 IPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF 243
I L TG + + L+YE Y + + D ++++ LTV+V D +D P F
Sbjct: 765 IELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWNDNAPRF 820
Query: 244 LPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYS 303
P YQ I E E+ I + D + D + Y+
Sbjct: 821 ------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DNGRVRYT 858
Query: 304 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHI 361
+L T + F +HP T EL + ++R+ ++ L ++A + GH L + L I
Sbjct: 859 LLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLII 913
Query: 362 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL-- 419
+ D N+ SP + + E P G ++ D DP+L
Sbjct: 914 TLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDASDPDLGP 956
Query: 420 -----HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---VQESEPV 471
++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 957 AGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPLARRTLC 1014
Query: 472 IVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 529
V + V+D N+N P F + V + G VI + A D D G +GE+ Y + G
Sbjct: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
Query: 530 -AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 588
F IN+ TG+I ++ Y LTV A D + +S+ VYIEV N+
Sbjct: 1075 TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIEVTDAND 1132
Query: 589 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 645
+PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F + T
Sbjct: 1133 -NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVT 1191
Query: 646 GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV-----FDPYL 699
G+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+ F+ L
Sbjct: 1192 GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRL 1251
Query: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSNGSIYTA 752
P LS V V ++ A+D D G+NG+V YS+ + + + + S+ S +TA
Sbjct: 1252 PERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTA 1308
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEEN 809
+Y L + ATD P +++ L I+ + S + F + Y+ V E
Sbjct: 1309 -------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
Query: 810 LPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 867
P ++ +E + N+S + + F + TG + + R LD +
Sbjct: 1362 DPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR----RR 1413
Query: 868 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
++ VE D G+ ++ ++N + P F + Y+ V D V G + V
Sbjct: 1414 SNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
Query: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTIFKLVVV 985
A D D + Y + Q P AS+F+++ SG ++T +++L P+ L V+
Sbjct: 1472 AIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVM 1526
Query: 986 AFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1040
D P+ + V I V LHP PRFTQ Y +A ++ V + A
Sbjct: 1527 VRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
Query: 1041 --INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
+N + YS++ GN E F IN + G+I + LD + L V+A+ +
Sbjct: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE-------DQG 1636
Query: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
P + A V I + + P+F K Y + E + + +L V A Y
Sbjct: 1637 SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE--- 1693
Query: 1159 YRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
++EG K+G F + +Y+GLI T + + S ++ ++ G ++G
Sbjct: 1694 -------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNMAGAFTD 1741
Query: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1252
++ VV+ +D N P L + ++E Y
Sbjct: 1742 VMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
Score = 232 bits (592), Expect = 2e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 332 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 390
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
Query: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
Query: 451 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 506
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Query: 507 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 563
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
Query: 564 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
Query: 623 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 676
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
Query: 677 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 734
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
Query: 735 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
Query: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
Query: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
Query: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
Query: 971 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1029
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
Query: 1030 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1084
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
Query: 1085 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
Query: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
Query: 1205 DYGK--GLSGKADVLVSVVNQLD 1225
D+G+ LS +A V VS+ ++ D
Sbjct: 2879 DHGQTIQLSSQALVQVSITDEND 2901
Score = 223 bits (567), Expect = 2e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 134
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
Query: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 193
+EL G V++ DP S DT + L+L+GN
Sbjct: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
Query: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 252
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
Query: 253 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 312
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
Query: 313 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 372
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
Query: 373 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
Query: 433 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 489
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
Query: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 543
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Query: 544 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
Query: 602 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 654
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
Query: 655 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 712
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
Query: 713 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 766
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
Query: 767 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 826
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
Query: 827 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
Query: 885 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 944
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
Query: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
Query: 1004 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1058
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
Query: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1176
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
Query: 1177 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
Score = 220 bits (560), Expect = 1e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
Query: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
Query: 233 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 291
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
Query: 292 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 351
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
Query: 352 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 411
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
Query: 412 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 469
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
Query: 470 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 527
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
Query: 528 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 586
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
Query: 587 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 645
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
Query: 646 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 704
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
Query: 705 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 759
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
Query: 820 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 877
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
Query: 878 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 937
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
Query: 938 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 997
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
Query: 998 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1047
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
Query: 1048 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1106
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
Query: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1156
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
Score = 218 bits (554), Expect = 6e-56
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 89 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 147
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
Query: 148 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 207
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
Query: 208 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 267
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
Query: 268 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 327
P EL + T +Q+R + L + D R +S
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
Query: 328 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 387
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
Query: 388 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 440
G I L++ A D D + P H F D TG
Sbjct: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
Query: 441 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
Query: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 560
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
Query: 561 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 620
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
Query: 621 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 678
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
Query: 679 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 732
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
Query: 733 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 789
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
Query: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 846
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
Query: 847 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 904
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
Query: 905 SKRIYKGMVAPDAVKGTPITTVYAEDADP 933
V D +G + ++A D DP
Sbjct: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
Score = 213 bits (542), Expect = 1e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 108 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 163
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
Query: 164 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 222
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
+ + V D +D P F I E+ ++P + +
Sbjct: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
Query: 283 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 342
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
Query: 343 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
Query: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
Query: 462 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
Query: 520 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 579
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
Query: 580 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 639
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
Query: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
Query: 700 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 754
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
Query: 755 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 814
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
Query: 815 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 872
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
Query: 873 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 930
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
Query: 931 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 988
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
Query: 989 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1044
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
Query: 1045 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1101
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1160
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
Query: 1161 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1202
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
Score = 200 bits (509), Expect = 1e-50
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 103 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 160
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
Query: 161 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 220
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
Query: 221 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 280
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
Query: 281 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 340
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
Query: 341 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
Query: 458 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 517
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
Query: 518 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 577
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
Query: 578 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 636
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
Query: 637 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 694
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
Query: 695 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 746
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
Query: 747 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
Query: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 862
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
Query: 863 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 922
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
Query: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
Query: 983 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1039
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
Query: 1040 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1093
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
Query: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
Query: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
+ + Y + P K+ + TG++K + F + A D
Sbjct: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
Score = 179 bits (454), Expect = 2e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
Query: 171 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 227
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
Query: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
Query: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
Query: 348 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
Query: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 464
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
Query: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
Query: 525 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 640
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
Query: 641 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 699
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
Query: 700 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 752
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
Query: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
Query: 813 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 842
G + +I A D D ++Y + E +HF
Sbjct: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
Score = 127 bits (319), Expect = 1e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 732 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 791
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Query: 792 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 851
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
Query: 852 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
Query: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
Query: 971 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1027
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
Query: 1028 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1087
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
Query: 1088 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1147
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
Query: 1148 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1204
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
Score = 77.0 bits (188), Expect = 2e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 625 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 674
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
Query: 675 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 734
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 791
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
Query: 792 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 836
S V T +TY TVLV+ N +G + +E D G
Sbjct: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
Query: 837 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 896
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
Query: 897 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 952
+ P F +I + P + + V + PPG VR V +
Sbjct: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
Query: 953 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1003
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
Query: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1059
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
Query: 1060 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
Query: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
Query: 1179 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1231
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 221 bits (562), Expect = 7e-57
Identities = 249/939 (26%), Positives = 395/939 (42%), Gaps = 123/939 (13%)
Query: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
FH+HP T + ++R+ + V L A + I + D N+ SP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 376 PSYQGYILESAPVGATI--------SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT 427
S Q + E +P G L T +V +D P L
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 428 SVFTVTQTGITR-----YLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDA 480
+ + G + L LL+ +DREE + I A+DG + + + V ++V+D
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 481 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV----------GA 530
NDN P F + Y V D +PG V ++ A D D G NG + Y + GA
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 531 QGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 587
GD F + + +G++ + ++ + L V+A D AE + V I VL N
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVRVSIAVLDVN 407
Query: 588 NQSPPRFPQLMYS---LEISEAMRVGAVLLNLQATDREGD------------------SI 626
+ P + +SE R G + + +D +GD SI
Sbjct: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
Query: 627 TYAIENGDPQRVFNLSETTGI--LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683
+ ++E G+ G+ L + LDRES D Y L++ A+D G P ++ T+ +
Sbjct: 468 SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL 527
Query: 684 VVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG-----------INGQVH 731
V D+ND P+F SV E A V V A+D D +
Sbjct: 528 RVADLNDQPPLFSQQ-HYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
Query: 732 YSLGNFNN----------LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
+LG+ + F I S +G+I T L+REV++ EL VVA D P +T
Sbjct: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
Query: 781 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI---- 834
++I V D++DN P+F Y + E+ P G LQ+ A D D G + Y +
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 835 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 894
S E F + P G++ + + +D E P A+ LVEA D G A V V +
Sbjct: 707 LSYEAPQAFRIDPHDGQICVSQDIDRERDP---ATYDLLVEAKDGGGLSAQ--AFVRVDL 761
Query: 895 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 954
+D+ND PVF+ Y ++ + GT I V A D D G+ + V Y + +
Sbjct: 762 EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD-SGIYGT-VAYELIPGNV---S 816
Query: 955 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSSATVKIL--VLHPGEI 1010
S+F ++ +G + + L+ +T L+V A D G V+++ T+ I L P E
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 1011 --PRFTQEEYRPPPVSELATKGTMVGVISA-AAINQS--IVYSIVSGNEEDTFGINNITG 1065
P++T Y P + + +G + A +N S I Y I SG+ F I+ G
Sbjct: 877 ERPKYTFLVYEDVP------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
Query: 1066 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1125
I PLD+ET+ VL VQ A L ++ +V I + D N++ P F +
Sbjct: 931 TIRTRKPLDHETQPVVVLTVQ--------AQLGSAPACSSTEVNITVMDVNDNHPAFLRT 982
Query: 1126 FYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
+S+ T++ +A D+D+G ++ Y + P
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
Score = 200 bits (509), Expect = 1e-50
Identities = 298/1218 (24%), Positives = 486/1218 (39%), Gaps = 176/1218 (14%)
Query: 103 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 154
+G ++ E+R V D ND+SP F +S V+EL+P GT + D A
Sbjct: 147 LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204
Query: 155 -----TDIDDGPNGQIEYVIQY-------NPDDPTSNDTFEIPLMLTGNIVLRKRLNYED 202
+D+ P G + ++Y +P P S+ E PL ++VL +RL+ E+
Sbjct: 205 TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLE-PL----DLVLLRRLDREE 258
Query: 203 KTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQA 262
+ + I+A D + RRT ++ + VLD +D P+F Y+A
Sbjct: 259 AAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVF------------EQDEYRA 303
Query: 263 AIPELRTPEELNPIIVTPPIQAIDQD-----------RNIQPPSDRPGILYSILVGTPED 311
A+ E+ P ++A D+D R Q P G G
Sbjct: 304 AV-----REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG-------GGALG 351
Query: 312 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 371
+F + + + + P++R+ LV++A P A + I +LD N+ P
Sbjct: 352 DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
Query: 372 ----YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE--------- 418
F + E A G ++ R+ D D + K+ E
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVA---------RVSVSDADGDWEKEDEATGELGVGL 462
Query: 419 ----LHLFLNDYTSVFTVTQTGI--TRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEP 470
+ L L F + G +L + P+DRE + Y + A D S
Sbjct: 463 GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN----------- 519
+ ++V D ND P F + Y V PG V+ ++A DADE +
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 520 -------GEITYEILVGAQ--GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
G + +++ A+ F I+ +G I+ ++ V L V A D P
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
Query: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSIT 627
++ C V I V N + P F + +Y+ I+E VG L + A+D + I
Sbjct: 643 --LSATCLVSITV-DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
Query: 628 YAIENG----DPQRVFNLSETTGILTLGKALDRE-STDRYILIITASDGRPDGTST-ATV 681
Y++ +G + + F + G + + + +DRE Y L++ A DG G S A V
Sbjct: 700 YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFV 757
Query: 682 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNN 739
+ + DVNDN PVF+P E + + V ATD D+GI G V Y L GN ++
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
Query: 740 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 798
LF I S G IY + L+ L+V A DG + I + F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 799 NSTYTVLVEENLPAGTTILQIEAKD-VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS 857
YT LV E++P + I ++A++ ++ + YRI S ++ F++HP G + +
Sbjct: 878 RPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKP 937
Query: 858 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPD 916
LD+E P + V+A G+ P +T V + V D+ND P F + + ++
Sbjct: 938 LDHETQP----VVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 917 AVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 974
GT + AED D GL +RY + Q +F ++ G + +L
Sbjct: 992 TPPGTALYLARAEDRDSGRNGL----IRYSIASPQ----PGVFAIDRALGVLFLNGSLGA 1043
Query: 975 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE---------EYRPPPVSE 1025
L + A D G ++ + +++ P +T E E P
Sbjct: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
Query: 1026 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
L T+ +G AA+ + YS+ + FGI TG IY+ DYE+ +Y RV
Sbjct: 1104 LQTQAHPLGPQRAAS---PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
Query: 1086 QADSLE-VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
A E L N+ + V + + DEN++ P F V E + ++
Sbjct: 1161 FAWIPEDGFLQNV-------STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKI 1213
Query: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
A D D+G + Y L + +GK F + TG + + R + + V+ TD
Sbjct: 1214 TAIDMDSGKNGQLLYFL----LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
Query: 1205 DYGKGLSGKADVLVSVVN 1222
+ V VSV +
Sbjct: 1269 RGSPPRNATMAVYVSVTD 1286
Score = 189 bits (479), Expect = 3e-47
Identities = 209/782 (26%), Positives = 316/782 (40%), Gaps = 79/782 (10%)
Query: 76 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135
ST R LDR+ + VV + V I V D NDN P F + Y AT+
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673
Query: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
E PVG A+D D G G IEY + + F I G I +
Sbjct: 674 EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH-DGQICVS 727
Query: 196 KRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 254
+ ++ E D Y ++++A D + + VD+ D +D P+F P V + D
Sbjct: 728 QDIDRERDPATYDLLVEAKDGGG-----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
Query: 255 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
E P + A DQD I + Y ++ P +
Sbjct: 783 -----------------ETQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSS 817
Query: 315 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374
F + T + L P++ L++ A+ G A + I I F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 375 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-T 433
P Y + E P SP+ V + + ++ + D F++
Sbjct: 878 RPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
Query: 434 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTFPEISY 492
+ G R +P+D E Q ++ A G + VNI VMD NDN P F S
Sbjct: 928 RLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSD 984
Query: 493 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 552
++ + PG ++ A D D G NG I Y I G F I++ G++ + +
Sbjct: 985 EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAG 1044
Query: 553 VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGA 611
R LT++A D + + TV IE SP F L+Y +E+SE++
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMT 1101
Query: 612 VLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 667
+L QA R + Y++E +F + TG + L + D EST Y +
Sbjct: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161
Query: 668 A---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATD 721
A DG ST TV + V D NDN+P F L L + EE+ +G++ A D
Sbjct: 1162 AWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGKITAID 1217
Query: 722 PDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
D+G NGQ+ Y L + F++ N G + V L+RE R ++E+ V+ TD PR++T
Sbjct: 1218 MDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNAT 1277
Query: 781 LTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI 834
+ + + V DI+DN P F V V E P + + AKD D G A V+Y +
Sbjct: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Query: 835 RS 836
S
Sbjct: 1338 SS 1339
Score = 184 bits (468), Expect = 6e-46
Identities = 268/1131 (23%), Positives = 458/1131 (40%), Gaps = 159/1131 (14%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDN P F+ + Y A V E G + ATD D GPNG + Y ++
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336
Query: 171 YNP-------DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
+ + L+G + + + L+ E + + ++++A D E
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA---EPE 393
Query: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTP 280
T +++ VLD D RP + + E R E P
Sbjct: 394 VATVRVSIAVLD----------------VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
Query: 281 PIQAIDQDRNIQPPSDRPGILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPV 331
+ D D + + + G L SI L G D+ P L + P+
Sbjct: 438 RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
Query: 332 NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 391
+R+ ++L++ A PL L + + D N+Q P F+ Y+ + E+A G
Sbjct: 498 DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
Query: 392 I-----SDS--------------LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432
+ SD+ + L++P + +L + T + ++ + +
Sbjct: 558 VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617
Query: 433 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEI 490
+T +DRE Q+ + A D + S +V+I V D NDN P F
Sbjct: 618 IRT-----------LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
Query: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITI 545
Y+ + G +Q+TA DAD G G I Y + G A F I+ G I +
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
Query: 546 APGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEI 603
+ ++ TY L V+A D + + ++ V L N + P F Y I
Sbjct: 727 SQDIDRERDPATYDLLVEAKDGGGLSAQ------AFVRVDLEDVNDNHPVFNPSTYVTSI 780
Query: 604 SEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 660
S+ + G ++N+ ATD++ ++ Y + G+ +F + TTGI+ L L +
Sbjct: 781 SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
Query: 661 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--N 711
L+++A DG G TA +N VT +F L P+ +V E+ +
Sbjct: 841 TLSLMVSAQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPED 892
Query: 712 AFVGQVKATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVV 768
+ +G VKA +P + + Y S G+ F I G+I T L+ E + L V
Sbjct: 893 SPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
A G+ P S+ + I V+D++DN P F ++ + + + P GT + A+D D G
Sbjct: 952 AQLGSA-PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
Query: 829 N--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 886
N + Y I SP+ FA+ G L L SL ++ +T + A D G P
Sbjct: 1011 NGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQA 1064
Query: 887 IATVTVIVKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVR 942
V +V + ++ P F +Y+ V+ +P+T + A P P AS +R
Sbjct: 1065 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLR 1121
Query: 943 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATV 1000
Y ++ +++F + +G + R + E T + V A+ +DG + + S TV
Sbjct: 1122 YSLEP---SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTV 1177
Query: 1001 KILVLHPGE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1053
+ V + P F + E P P + G + + + N ++Y ++S
Sbjct: 1178 IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDG 1234
Query: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
+ F +N TG + LD E R + + V++ + P ++ T VY+ +
Sbjct: 1235 K--FFKMNPNTGELINWVALDREHRGHH-------EMTVLVTDRGSPPRNATMAVYVSVT 1285
Query: 1114 DENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1159
D N++ P F K+ ++ V E + V V A D D GN + + Y
Sbjct: 1286 DINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Score = 147 bits (372), Expect = 8e-35
Identities = 185/746 (24%), Positives = 315/746 (42%), Gaps = 122/746 (16%)
Query: 609 VGAVLLNLQATDREGDSITYAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILI 665
VG + L A ++ S + E+ D + F++ TGI+ + LDRE D Y +
Sbjct: 83 VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFV 142
Query: 666 ITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDA 724
G + V I V DVND++P F L ++S + AF V A DPDA
Sbjct: 143 AATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPV-AHDPDA 196
Query: 725 GINGQVHYSLGNFNNL----------FRITSNGSIYTAV-----------------KLNR 757
G+ Y+L ++L R + G + + + +L+R
Sbjct: 197 GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDR 256
Query: 758 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
E + L + A DG R L++ ++VLD +DN PVF Y V E+ G +
Sbjct: 257 EEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVC 316
Query: 818 QIEAKDVDLGAN--VSYRIRSPEV------------KHFFALHPFTGELSLLRSLDYEAF 863
++ A D DLG N V Y +R+ +V +FA+ +G + + R LD EA
Sbjct: 317 RVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREA- 375
Query: 864 PDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP----VFSKRIYKGMVAPDA 917
+A +VEA D G P +AT V++ V D+ND P +F V+ A
Sbjct: 376 ---QAWHQLVVEARD--GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430
Query: 918 VKGTPITTVYAEDADPP-------------GLPASRVRYRVDDVQFPY------PASIFE 958
G + V DAD GL + ++ + + P +F
Sbjct: 431 RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVF- 489
Query: 959 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1018
+ L+ E +++L++VA D G P +S+ T+ + V + P +++
Sbjct: 490 ------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
Query: 1019 RPPPVSELATKGTMVGVISAAAINQS------IVYSIVS-------GNEED--------- 1056
VSE A GT+V +SA+ +++ + Y++V G+ +
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
Query: 1057 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
+F I++ +G I LD E + +A L+VV +L P S T V I + D
Sbjct: 604 PSFAIDSESGAISTIRTLDREVQ-------EAVELKVVAQDLGEPPLSATCLVSITVDDV 656
Query: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK-EGKEGFV 1174
N++ P+F ++ Y ++E A + L+V A+D D+G Y + Y L + E + F
Sbjct: 657 NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 1175 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS-NV 1233
++ + G I + + R + ++ G GLS +A V V + + D + + +
Sbjct: 717 IDPHDGQICVSQDI-DRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 1234 PPTLVEKKIEDLTEILDRYVQEQIPG 1259
T + + + TEI++ +Q G
Sbjct: 776 YVTSISDETQPGTEIINVLATDQDSG 801
Score = 33.1 bits (74), Expect = 2.7
Identities = 26/70 (37%), Positives = 29/70 (41%), Gaps = 2/70 (2%)
Query: 1733 ISPPSPPPAP--APLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL 1790
+S SPP P+A PD FS PS P FF L T GP PL
Sbjct: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
Query: 1791 LPPFPTPLPP 1800
LP +PL P
Sbjct: 236 LPGSSSPLEP 245
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 441 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 499 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 554
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 555 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 613
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 614 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 670
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 671 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 727
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 728 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 787 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 846
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 847 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 904
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 905 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 2e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 596 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 646
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 647 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 693 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 747
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 748 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 804 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 858
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 859 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 918
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 919 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 968
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 969 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1028
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1029 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1084
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1085 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1205 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1255
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 4e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 327 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 384
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 385 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 439
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 440 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 493
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 494 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 545
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 546 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 605
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 606 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 664
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 665 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 718
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 719 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 777
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 778 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 831
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 832 YRIRSPEVKHFFALHPFTGELSL 854
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 7e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 473 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 531
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 532 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 640
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 641 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 699
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 700 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 751
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 872 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 930
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 931 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 990
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 991 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1041
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVI 1067
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 141 bits (356), Expect = 5e-33
Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 170 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 404
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 405 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 464
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 465 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 523 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Y++ A F +++ TG++T + + + TV A DN P S V +
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561
Query: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 639
VL N+ S P+F + +SE + + + + TD E ++T +I N + F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618
Query: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 697
L +G++ + DRE Y + A+D G+P +STA V I V DVNDN+P V P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678
Query: 698 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 743
+ +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 102 bits (253), Expect = 5e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)
Query: 256 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 315 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 361
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 362 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 421
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 422 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 479
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 480 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 535
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 536 INKTTGLITI 545
I+ TG IT+
Sbjct: 728 IDPVTGNITL 737
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 351 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 408 DKDIEDTKDP 417
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 441 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 499 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 554
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 555 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 613
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 614 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 670
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 671 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 727
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 728 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 787 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 846
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 847 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 904
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 905 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 992
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 2e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 596 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 646
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 647 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 693 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 747
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 748 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 804 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 858
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 859 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 918
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 919 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 968
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 969 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1028
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1029 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1084
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1085 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1145 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1205 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1255
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 4e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 327 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 384
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 385 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 439
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 440 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 493
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 494 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 545
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 546 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 605
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 606 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 664
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 665 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 718
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 719 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 777
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 778 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 831
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 832 YRIRSPEVKHFFALHPFTGELSL 854
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 7e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 473 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 531
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 532 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 586
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 587 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 640
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 641 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 699
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 700 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 751
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 872 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 930
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 931 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 990
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 991 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1041
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVI 1067
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 141 bits (356), Expect = 5e-33
Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)
Query: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 170 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 404
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 405 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 464
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 465 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 523 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Y++ A F +++ TG++T + + + TV A DN P S V +
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561
Query: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 639
VL N+ S P+F + +SE + + + + TD E ++T +I N + F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618
Query: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 697
L +G++ + DRE Y + A+D G+P +STA V I V DVNDN+P V P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678
Query: 698 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 743
+ +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 102 bits (253), Expect = 5e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)
Query: 256 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 314
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 315 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 361
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 362 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 421
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 422 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 479
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 480 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 535
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 536 INKTTGLITI 545
I+ TG IT+
Sbjct: 728 IDPVTGNITL 737
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 351 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 408 DKDIEDTKDP 417
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 277
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 278 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 337
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 338 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 456
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 457 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 515 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 625
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 626 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 681
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 682 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 739
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 740 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 798
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 858
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 859 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 915
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 916 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 976 PTTIFKLVVVAFDDGEP 992
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 531 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 637
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 696
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 697 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 742
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 743 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 802
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 861
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 919
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1032
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1090
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1091 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 602 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 655
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 656 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 709 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 759
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 820 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 874
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 875 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 928
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 929 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1041
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1221
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1222 NQLDMQVIVSNVPP 1235
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 76 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 129
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 130 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 188
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 189 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 248
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 249 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 368
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 369 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 427
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435
Query: 428 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 484
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 544
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555
Query: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612
Query: 605 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 663
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 664 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 719
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 720 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 776
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779
Query: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 825
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 277
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 278 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 337
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 338 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 456
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 457 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 515 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 625
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 626 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 681
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 682 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 739
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 740 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 798
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 858
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 859 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 915
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 916 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 976 PTTIFKLVVVAFDDGEP 992
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 531 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 637
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 696
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 697 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 742
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 743 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 802
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 861
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 919
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1032
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1090
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1091 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 602 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 655
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 656 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 709 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 759
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 820 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 874
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 875 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 928
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 929 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1041
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1221
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1222 NQLDMQVIVSNVPP 1235
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 76 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 129
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 130 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 188
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 189 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 248
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 249 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 368
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 369 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 427
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435
Query: 428 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 484
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 544
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555
Query: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612
Query: 605 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 663
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 664 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 719
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 720 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 776
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779
Query: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 825
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 223 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 277
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 14 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 73
Query: 278 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 337
+ Q + + D P L+ ED F R L + RD H
Sbjct: 74 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 127
Query: 338 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 397
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 128 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 180
Query: 398 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 456
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 181 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 237
Query: 457 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 238 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 297
Query: 515 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 298 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 357
Query: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 625
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 358 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413
Query: 626 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 681
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 414 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 473
Query: 682 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 739
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 474 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 532
Query: 740 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 798
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 533 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 592
Query: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 858
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 593 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 859 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 915
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 653 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 708
Query: 916 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 709 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 763
Query: 976 PTTIFKLVVVAFDDGEP 992
+ +++V A D G+P
Sbjct: 764 DLGLHRVLVKANDLGQP 780
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 144 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 202
Query: 531 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 260
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 637
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 261 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 696
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 378
Query: 697 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 742
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 379 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 743 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 802
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 439 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 861
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 919
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 553 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 606
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 607 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 659
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1032
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 660 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1090
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 720 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 779
Query: 1091 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
VV+ NL V A + E+ ++ PV
Sbjct: 780 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 602 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 655
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 54 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 113
Query: 656 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 114 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 172
Query: 709 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 759
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 173 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 233 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 292
Query: 820 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 874
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 293 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 348
Query: 875 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 928
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 349 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406
Query: 929 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 407 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 459
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1041
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 460 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 518
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 519 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 570
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 571 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630
Query: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1221
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 631 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 1222 NQLDMQVIVSNVPP 1235
+ D + + VPP
Sbjct: 686 DVNDNKPVFI-VPP 698
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 76 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 129
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 107 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 161
Query: 130 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 188
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 162 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 218
Query: 189 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 248
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 219 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 270
Query: 249 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
+ + +IPE N + T Q D +I + I +S
Sbjct: 271 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 313
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 368
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 314 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 371
Query: 369 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 427
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 372 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 424
Query: 428 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 484
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 425 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484
Query: 485 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 544
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 544
Query: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 545 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 601
Query: 605 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 663
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 602 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 661
Query: 664 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 719
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 662 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 721
Query: 720 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 776
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 722 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 768
Query: 777 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 825
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 769 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 812
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 285
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 286 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 345
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 406 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 464
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 465 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 523 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 579 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 630
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 631 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 747
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 748 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 807 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 866
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 867 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 922
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 983 VVVAFDDGEP 992
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 531 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 637
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 696
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 697 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 742
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 743 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 802
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 861
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 919
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1032
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1090
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1091 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 6e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 602 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 655
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 656 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 709 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 759
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 820 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 874
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 875 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 928
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 929 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1041
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1221
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1222 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1276
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1277 SLEDYT-------KCDLT 1287
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 163 bits (412), Expect = 2e-39
Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)
Query: 76 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 129
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 130 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 188
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 189 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 248
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 249 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 368
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 369 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 421
P + YI+ +S+++ L + + ++ + DKD + D E+
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406
Query: 422 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 479
L S + +T YL D E + Y + A D + ++ ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458
Query: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 539
NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518
Query: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575
Query: 600 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
+ + E + R G V L GD+ + D F + TG++ + DRE
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 659 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 713
+ Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694
Query: 714 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 770
V QV A D D G+N +V YS+ GN +LF I G+I K + T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742
Query: 771 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 825
D +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 285
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 286 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 345
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 346 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 405
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 406 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 464
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 465 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 523 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 579 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 630
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 631 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 690 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 747
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 748 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 806
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 807 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 866
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 867 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 922
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 923 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 982
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 983 VVVAFDDGEP 992
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 471 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 530
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 531 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 637
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 696
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 697 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 742
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 743 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 802
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 803 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 861
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 862 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 919
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 920 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 979
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 980 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1032
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1090
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1091 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1121
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 6e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 602 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 655
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 656 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 709 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 759
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 760 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 819
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 820 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 874
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 875 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 928
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 929 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 986
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 987 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1041
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1101
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1102 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1161
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1221
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1222 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1276
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1277 SLEDYT-------KCDLT 1287
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 163 bits (412), Expect = 2e-39
Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)
Query: 76 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 129
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 130 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 188
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 189 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 248
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 249 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 308
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 309 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 368
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 369 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 421
P + YI+ +S+++ L + + ++ + DKD + D E+
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406
Query: 422 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 479
L S + +T YL D E + Y + A D + ++ ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458
Query: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 539
NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518
Query: 540 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 599
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575
Query: 600 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
+ + E + R G V L GD+ + D F + TG++ + DRE
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 659 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 713
+ Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694
Query: 714 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 770
V QV A D D G+N +V YS+ GN +LF I G+I K + T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742
Query: 771 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 825
D +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,639,046
Number of Sequences: 37866
Number of extensions: 4847842
Number of successful extensions: 120802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 959
Number of HSP's successfully gapped in prelim test: 1175
Number of HSP's that attempted gapping in prelim test: 35400
Number of HSP's gapped (non-prelim): 37773
length of query: 1935
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1818
effective length of database: 13,817,196
effective search space: 25119662328
effective search space used: 25119662328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.