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Search of human proteins with 218505783
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo
sapiens]
(1915 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 3834 0.0
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 3816 0.0
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 3810 0.0
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 3804 0.0
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 3798 0.0
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 3752 0.0
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 3747 0.0
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 2795 0.0
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 2795 0.0
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 2789 0.0
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 2782 0.0
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 2593 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 332 2e-90
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 318 4e-86
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 303 1e-81
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 301 5e-81
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 292 2e-78
gi|16933557 dachsous 1 precursor [Homo sapiens] 283 1e-75
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 282 2e-75
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 278 3e-74
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 270 1e-71
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 268 4e-71
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 221 7e-57
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 206 1e-52
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 206 1e-52
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 198 4e-50
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 198 4e-50
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 198 4e-50
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 195 4e-49
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 195 4e-49
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 3834 bits (9943), Expect = 0.0
Identities = 1915/1915 (100%), Positives = 1915/1915 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 240
DGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC
Sbjct: 181 DGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 240
Query: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF
Sbjct: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
Query: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT
Sbjct: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
Query: 421 GITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY 480
GITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY
Sbjct: 421 GITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY 480
Query: 481 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 540
VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR
Sbjct: 481 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 540
Query: 541 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 600
TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN
Sbjct: 541 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 600
Query: 601 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 660
LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG
Sbjct: 601 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 660
Query: 661 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG
Sbjct: 661 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
Query: 721 NFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 780
NFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP
Sbjct: 721 NFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 780
Query: 781 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 840
VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL
Sbjct: 781 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 840
Query: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 900
RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP
Sbjct: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 900
Query: 901 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 960
DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE
Sbjct: 901 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 960
Query: 961 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1020
PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV
Sbjct: 961 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1020
Query: 1021 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA
Sbjct: 1021 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
Query: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS
Sbjct: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
Query: 1141 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1200
VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD
Sbjct: 1141 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1200
Query: 1201 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDA 1260
VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDA
Sbjct: 1201 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDA 1260
Query: 1261 FSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTP 1320
FSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTP
Sbjct: 1261 FSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTP 1320
Query: 1321 EAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALP 1380
EAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALP
Sbjct: 1321 EAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALP 1380
Query: 1381 AAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQ 1440
AAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQ
Sbjct: 1381 AAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQ 1440
Query: 1441 VVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNS 1500
VVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNS
Sbjct: 1441 VVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNS 1500
Query: 1501 DISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQW 1560
DISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQW
Sbjct: 1501 DISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQW 1560
Query: 1561 QGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDS 1620
QGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDS
Sbjct: 1561 QGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDS 1620
Query: 1621 SFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPIC 1680
SFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPIC
Sbjct: 1621 SFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPIC 1680
Query: 1681 MLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPP 1740
MLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPP
Sbjct: 1681 MLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPP 1740
Query: 1741 PSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTEC 1800
PSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTEC
Sbjct: 1741 PSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTEC 1800
Query: 1801 VCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMY 1860
VCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMY
Sbjct: 1801 VCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMY 1860
Query: 1861 SQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
SQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1861 SQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 3816 bits (9895), Expect = 0.0
Identities = 1915/1952 (98%), Positives = 1915/1952 (98%), Gaps = 37/1952 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1344 AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP 1403
AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP 1440
Query: 1404 GAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLK 1463
GAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLK
Sbjct: 1441 GAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLK 1500
Query: 1464 SNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSL 1523
SNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSL
Sbjct: 1501 SNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSL 1560
Query: 1524 RGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSN 1583
RGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSN
Sbjct: 1561 RGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSN 1620
Query: 1584 PLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVEL 1643
PLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVEL
Sbjct: 1621 PLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVEL 1680
Query: 1644 KSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPS 1703
KSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPS
Sbjct: 1681 KSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPS 1740
Query: 1704 ACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTS 1763
ACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTS
Sbjct: 1741 ACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTS 1800
Query: 1764 GPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMT 1823
GPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMT
Sbjct: 1801 GPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMT 1860
Query: 1824 QLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEV 1883
QLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEV
Sbjct: 1861 QLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEV 1920
Query: 1884 TNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
TNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 TNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1952
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 3810 bits (9881), Expect = 0.0
Identities = 1915/1955 (97%), Positives = 1915/1955 (97%), Gaps = 40/1955 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1401 PPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDG 1460
PPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDG
Sbjct: 1441 PPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDG 1500
Query: 1461 SLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKS 1520
SLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKS
Sbjct: 1501 SLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKS 1560
Query: 1521 KSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRG 1580
KSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRG
Sbjct: 1561 KSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRG 1620
Query: 1581 SSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRT 1640
SSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRT
Sbjct: 1621 SSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRT 1680
Query: 1641 VELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNI 1700
VELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNI
Sbjct: 1681 VELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNI 1740
Query: 1701 SPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSV 1760
SPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSV
Sbjct: 1741 SPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSV 1800
Query: 1761 STSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKS 1820
STSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKS
Sbjct: 1801 STSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKS 1860
Query: 1821 SMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCP 1880
SMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCP
Sbjct: 1861 SMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCP 1920
Query: 1881 SEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
SEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 SEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1955
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 3804 bits (9865), Expect = 0.0
Identities = 1914/1957 (97%), Positives = 1915/1957 (97%), Gaps = 42/1957 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1401 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1458
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1441 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1500
Query: 1459 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1518
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1501 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1560
Query: 1519 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1578
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1561 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1620
Query: 1579 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1638
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1621 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1680
Query: 1639 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1698
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1681 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1740
Query: 1699 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1758
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1741 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1800
Query: 1759 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1818
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1801 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1860
Query: 1819 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1878
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1861 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1920
Query: 1879 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1957
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 3798 bits (9849), Expect = 0.0
Identities = 1914/1962 (97%), Positives = 1915/1962 (97%), Gaps = 47/1962 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDP------------------------------------- 198
ATDIDDGPNGQIEYVIQYNPDDP
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 199 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 258
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 259 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 318
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 319 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 379 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 438
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 439 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 498
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 499 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 558
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 559 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 618
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 619 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 678
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 679 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 738
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 739 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 798
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 799 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 858
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 859 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 918
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 919 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 978
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 979 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1038
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1039 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1098
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1099 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1158
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1159 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1218
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1219 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1278
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1279 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1338
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1339 ALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAP 1395
ALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1396 PPPPPPPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1453
PPPPPPPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1500
Query: 1454 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1513
KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS
Sbjct: 1501 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1560
Query: 1514 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1573
PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG
Sbjct: 1561 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1620
Query: 1574 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1633
ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST
Sbjct: 1621 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1680
Query: 1634 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1693
LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN
Sbjct: 1681 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1740
Query: 1694 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1753
FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP
Sbjct: 1741 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1800
Query: 1754 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1813
TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM
Sbjct: 1801 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1860
Query: 1814 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1873
PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS
Sbjct: 1861 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1920
Query: 1874 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1962
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 3752 bits (9731), Expect = 0.0
Identities = 1892/1954 (96%), Positives = 1893/1954 (96%), Gaps = 61/1954 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1344 AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP 1403
AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPP 1418
Query: 1404 GAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGS 1461
GAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGS
Sbjct: 1419 GAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGS 1478
Query: 1462 LKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSK 1521
LKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSK
Sbjct: 1479 LKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSK 1538
Query: 1522 SLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGS 1581
SLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGS
Sbjct: 1539 SLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGS 1598
Query: 1582 SNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTV 1641
SNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTV
Sbjct: 1599 SNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTV 1658
Query: 1642 ELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNIS 1701
ELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNIS
Sbjct: 1659 ELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNIS 1718
Query: 1702 PSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVS 1761
PSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVS
Sbjct: 1719 PSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVS 1778
Query: 1762 TSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSS 1821
TSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSS
Sbjct: 1779 TSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSS 1838
Query: 1822 MTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPS 1881
MTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPS
Sbjct: 1839 MTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPS 1898
Query: 1882 EVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
EVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1899 EVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1932
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 3747 bits (9717), Expect = 0.0
Identities = 1892/1957 (96%), Positives = 1893/1957 (96%), Gaps = 64/1957 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
Query: 1401 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1458
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
Query: 1459 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1518
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
Query: 1519 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1578
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
Query: 1579 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1638
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
Query: 1639 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1698
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
Query: 1699 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1758
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
Query: 1759 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1818
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
Query: 1819 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1878
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
Query: 1879 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 2795 bits (7245), Expect = 0.0
Identities = 1415/1456 (97%), Positives = 1416/1456 (97%), Gaps = 40/1456 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1401 PPPGAHLYEELGDSSI 1416
PPPGAHLYEELGDSS+
Sbjct: 1441 PPPGAHLYEELGDSSM 1456
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 2795 bits (7245), Expect = 0.0
Identities = 1415/1456 (97%), Positives = 1416/1456 (97%), Gaps = 40/1456 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1401 PPPGAHLYEELGDSSI 1416
PPPGAHLYEELGDSS+
Sbjct: 1441 PPPGAHLYEELGDSSM 1456
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 2789 bits (7229), Expect = 0.0
Identities = 1415/1461 (96%), Positives = 1416/1461 (96%), Gaps = 45/1461 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDP------------------------------------- 198
ATDIDDGPNGQIEYVIQYNPDDP
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 199 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 258
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 259 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 318
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 319 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 379 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 438
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 439 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 498
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 499 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 558
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 559 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 618
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 619 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 678
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 679 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 738
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 739 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 798
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 799 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 858
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 859 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 918
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 919 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 978
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 979 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1038
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1039 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1098
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1099 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1158
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1159 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1218
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1219 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1278
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1279 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1338
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1339 ALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAP 1395
ALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1396 PPPPPPPPGAHLYEELGDSSI 1416
PPPPPPPPGAHLYEELGDSS+
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSM 1461
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 2782 bits (7211), Expect = 0.0
Identities = 1415/1468 (96%), Positives = 1416/1468 (96%), Gaps = 52/1468 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDP------------------------------------- 198
ATDIDDGPNGQIEYVIQYNPDDP
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 199 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 258
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 259 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 318
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 319 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 379 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
Query: 432 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 491
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 492 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 551
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 552 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 611
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 612 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 671
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 672 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 731
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
Query: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 911
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 912 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 972 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1031
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
Query: 1032 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1091
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Query: 1092 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1151
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
Query: 1152 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1211
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Query: 1212 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1271
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
Query: 1272 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1331
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
Query: 1332 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPA 1388
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
Query: 1389 PAPVAAPPPPPPPPPGAHLYEELGDSSI 1416
PAPVAAPPPPPPPPPGAHLYEELGDSS+
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSM 1468
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 2593 bits (6721), Expect = 0.0
Identities = 1367/1684 (81%), Positives = 1442/1684 (85%), Gaps = 83/1684 (4%)
Query: 307 TAELSLLEPVNRDFHQKFDLVIKAE---QDNGHPLPAFAGLHIEILDENNQSPYFT---- 359
T + L + +N + ++ ++I+A Q+ L +++LD ++ P F
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 360 MPSYQG---YILESAPVGATISDSLN---LTSPLRIVALDKDIEDTKDPELHLFL----- 408
+P+ + ++A + LN +T P++ + D++I+ D L+
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 409 -NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDA 465
DY F + T L+LL+PV+R+ Q + I A P ++I+++D
Sbjct: 331 PEDYPRFFHMHPR--TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 388
Query: 466 NDNTPTFPEISYDVYVYTDMRPGDSV---------IQLTAVDAD-EGSNGEITYEILVGA 515
N+ +P F SY Y+ G ++ +++ A+D D E + + L
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
Query: 516 QGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
F + +T T +T+ V+ +TY ++ A D +E V I+V+ N+
Sbjct: 449 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDAND 504
Query: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 630
+P FP++ Y + + MR G ++ L A D + S ITY I G Q F +++TT
Sbjct: 505 NTPT-FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT 562
Query: 631 G----------------------------------ILTLGKALDRESTDRYILIITASDG 656
G ILTLGKALDRESTDRYILIITASDG
Sbjct: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG 622
Query: 657 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 716
RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH
Sbjct: 623 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 682
Query: 717 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 776
YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID
Sbjct: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Query: 777 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 836
DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE
Sbjct: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
Query: 837 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 896
LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG
Sbjct: 803 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 862
Query: 897 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 956
MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN
Sbjct: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
Query: 957 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1016
LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT
Sbjct: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 982
Query: 1017 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1076
MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE
Sbjct: 983 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1042
Query: 1077 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1136
VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT
Sbjct: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
Query: 1137 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1196
GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS
Sbjct: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
Query: 1197 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1256
GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR
Sbjct: 1163 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1222
Query: 1257 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1316
HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE
Sbjct: 1223 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1282
Query: 1317 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQ---RQAECTKTA 1373
IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQ RQAECTKTA
Sbjct: 1283 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1342
Query: 1374 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSI--LFLLYHFQQSRGNNS 1431
RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSS+ LFLLYHFQQSRGNNS
Sbjct: 1343 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNS 1402
Query: 1432 VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE 1491
VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE
Sbjct: 1403 VSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKE 1462
Query: 1492 NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR 1551
NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR
Sbjct: 1463 NISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNR 1522
Query: 1552 PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE 1611
PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE
Sbjct: 1523 PEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTE 1582
Query: 1612 QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS 1671
QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS
Sbjct: 1583 QLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSS 1642
Query: 1672 LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI 1731
LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI
Sbjct: 1643 LSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDI 1702
Query: 1732 SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP 1791
SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP
Sbjct: 1703 SPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPP 1762
Query: 1792 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE 1851
SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE
Sbjct: 1763 SASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAE 1822
Query: 1852 LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ 1911
LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ
Sbjct: 1823 LEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQ 1882
Query: 1912 STSL 1915
STSL
Sbjct: 1883 STSL 1886
Score = 1172 bits (3032), Expect = 0.0
Identities = 689/1134 (60%), Positives = 767/1134 (67%), Gaps = 124/1134 (10%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI-- 561
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 562 -----------------------------CTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
TV I V N+ +P P L +L + E
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE- 659
Query: 593 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
A + ++ATD + + Y++ G+ +F ++ I T K L+RE D Y L
Sbjct: 660 EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYEL 716
Query: 650 IITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 708
++ A+DG ST T+ I V D++DN+PVF L A + Q++A D D
Sbjct: 717 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776
Query: 709 AGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE----LVVVATD--GAVHP 761
G N + F + G + L+ E E +V A D G + P
Sbjct: 777 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
Query: 762 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD----LGANVSY 817
+T+T+ +K D++D PVF+ Y +V + GT I + A+D D + V Y
Sbjct: 837 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
Query: 818 R---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 874
R ++ P F + +G + +L+ E +V AFD + AT
Sbjct: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLVVVAFDDGEPVMSSSAT 950
Query: 875 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
V ++V + P + V+ A KGT + + A A + S V +D
Sbjct: 951 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AINQSIVYSIVSGNEEDT- 1008
Query: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM------SSSATVKIL 988
F + +G + L+ E T + L V A D E V+ S S T K+
Sbjct: 1009 -------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVY 1060
Query: 989 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1042
+ EI Q+E PPV + K + GV A + S++ V ++DT
Sbjct: 1061 I----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR--VKATDKDT 1102
Score = 133 bits (334), Expect = 2e-30
Identities = 228/910 (25%), Positives = 357/910 (39%), Gaps = 151/910 (16%)
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 403
+ I + D N+ SP F SY + E PVG TI + + DI+D + +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA------TDIDDGPNGQ 186
Query: 404 LHLFL----NDYTSVFT----------------VTQTGITRYLTLLQPVDREEQ------ 437
+ + +D TS T + TRY ++Q DR +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 438 QTYTFSITAFDGVQESEPVIVNIQVMDANDNTP-TFPEISYDVYVYTDMRPGDSVIQLTA 496
T T ++ DG + + V + D P T+ ++ ++ P + A
Sbjct: 247 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
Query: 497 VDADE-----GSNGEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQ 547
+D D I Y ILVG D F ++ T +++ V + + L ++
Sbjct: 307 IDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 548 A-ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL-------- 598
A DN P + ++IE+L NNQS P F Y I E+ VGA +
Sbjct: 367 AEQDNGHPLP---AFAGLHIEILDENNQS-PYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 599 -LNLQATDRE----GDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILII 651
L + A D++ D + N D VF +++T T LTL + +DRE Y I
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 481
Query: 652 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV-VEEEANAFVGQVKATDPDAG 710
TA DG + + VNI V D NDN P F P + ++ V + V Q+ A D D G
Sbjct: 482 TAFDGVQE-SEPVIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
Query: 711 INGQVHYSL-----GNF-------------------NNLFRIT------------SNGSI 734
NG++ Y + G+F + +T S G +
Sbjct: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
Query: 735 YTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 794
L+RE D Y L++ A+DG ST T+ I V D++DN+PVF L
Sbjct: 600 TLGKALDRESTDRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVE 658
Query: 795 LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 854
A + Q++A D D G N + F + G + L+ E E
Sbjct: 659 EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE-- 715
Query: 855 ITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 912
+V A D G + P +T+T+ +K D++D PVF+ Y +V + GT I +
Sbjct: 716 --LVVVATD--GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 771
Query: 913 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLV 968
A+D D + V YR ++ P F + +G + +L+ E +
Sbjct: 772 AKDVD----LGANVSYR---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
Query: 969 VVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AIN 1027
V AFD + ATV ++V + P + V+ A KGT + + A A
Sbjct: 825 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
Query: 1028 QSIVYSIVSGNEEDT--------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1078
+ S V +D F + +G + L+ E T + L V A D E V
Sbjct: 885 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 944
Query: 1079 LANLRVPSKSNTAKVYI----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR 1128
+ S S T K+ + EI Q+E PPV + K + GV A + S++
Sbjct: 945 M------SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY 998
Query: 1129 --VKATDKDT 1136
V ++DT
Sbjct: 999 SIVSGNEEDT 1008
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 332 bits (851), Expect = 2e-90
Identities = 320/1144 (27%), Positives = 508/1144 (44%), Gaps = 100/1144 (8%)
Query: 132 EVRIVVRDRNDNSPTFKHE-----SYYATVNELTPVGTTI--FTGFSGDNGATDIDD--- 181
E I + D NDN P K S YA+V+E VGT + T D+ A + +
Sbjct: 338 EALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQ 397
Query: 182 --GPNGQIEYVIQY----NPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGP--------M 227
G N Q + +Q N A L+ R + LTV V D P
Sbjct: 398 ILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSS 457
Query: 228 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 287
V+ N + P + + + EE P I A D D + + Y
Sbjct: 458 VASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNA-----NLRY 512
Query: 288 SILVGTPEDYPRFFHM--HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 345
SI+ G + FH+ H ++R+ + L I A HP ++A L
Sbjct: 513 SIVSGNGLGW---FHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLV 569
Query: 346 IEILDENNQSPYFTMP-SYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
+ +LD N++ P F+ P Y ++E+AP G T L + A D D+ D
Sbjct: 570 VTLLDVNDEKPVFSQPEGYDVSVVENAPTG---------TELLMLRATDGDLGDNGTVRF 620
Query: 405 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQV 462
L T + ++ L+ + +DREEQ Y+ + A D +S +N+ +
Sbjct: 621 SL-QEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSL 679
Query: 463 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIIN 522
+D NDN+P F + Y ++ + G + ++A D D G+NG + Y I G + F +N
Sbjct: 680 LDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVN 739
Query: 523 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 582
+G+I+ ++ Y L + A D +I T+ + +PP F Q+
Sbjct: 740 AQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI---TVLDTQDNPPVFSQV 796
Query: 583 MYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDR 641
YS + E + +G + ++ A+ + +I+Y I GD + +F +++ TG LT +DR
Sbjct: 797 AYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDR 856
Query: 642 ESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVG 700
E Y L + AS G G + VNI V D+NDN+P F + +++VVE +A +
Sbjct: 857 EEQSFYQLKVVASGGTVTGDT--MVNITVKDLNDNSPHFLQAI-ESVNVVENWQAGHSIF 913
Query: 701 QVKATDPDAGINGQVHYSL-GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGA 758
Q KA DPD G+NG V YSL N NLF I NG+I L+ Y++ ++A+D
Sbjct: 914 QAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS-YQIEILASDMG 972
Query: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
V S++ L + V D++DNSPVF +Y V + E+ P + +++A D D GAN ++
Sbjct: 973 VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIA 1032
Query: 817 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 876
Y I F + P G+L + LD E + +V A D VT
Sbjct: 1033 YTIAEGNTGDAFGIFP-DGQLYIKSELDREL----QDRYVLMVVASDRAVEPLSATVNVT 1087
Query: 877 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
VI++D+ND P+F+ Y + G+ + V A D D P VRY + VQ
Sbjct: 1088 VILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFG--PNGEVRYSFEMVQ-- 1143
Query: 937 YPASIFEVEEDSGRVITRVNLNEEP------TTIFKLVVVAFDDGEP-VMSSSATVKILV 989
FE+ SG + + E T +F V+A D G P + ATV + +
Sbjct: 1144 ---PDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYM 1200
Query: 990 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFG 1044
+ P+F ++ Y+ +SE A T V +SA+ +++ I YSI+ GNEE F
Sbjct: 1201 KDINDNAPKFLKDFYQ-ATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFA 1259
Query: 1045 INNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
I++ +G + + G LDYE +Y L +QA DS + L ++T + I+I DEN++
Sbjct: 1260 IDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPL--------NSTCTLNIDILDENDN 1311
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
P F K V E+ R+ V V ATD D+G+ + + Y + F +
Sbjct: 1312 TPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI---TGTNNHGTFSISPN 1368
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
TG I A +S +K + A D +G ++ + V++ D + PP +
Sbjct: 1369 TGSIFLAKKLDFETQSLYKLNITAKD---QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDI 1425
Query: 1224 EKKI 1227
K I
Sbjct: 1426 FKSI 1429
Score = 332 bits (851), Expect = 2e-90
Identities = 310/1165 (26%), Positives = 514/1165 (44%), Gaps = 118/1165 (10%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
T +LDR+ ++ +V V I K EV I ++D NDN P F + TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDR----------AQNLNE 206
E G+ I A D D+G N + Y I DD R + L+
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDR 1804
Query: 207 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 266
R + +L V DG M + + V + D P + + PE+ P +
Sbjct: 1805 ERRSKYSLLVRADDGLQSSDMRIN-ITVSDVNDHTP-KFSRPVYSFDIPEDTIPGSLVAA 1862
Query: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 326
I A D D + I Y + +D F ++P T +L ++ + Q + L
Sbjct: 1863 ILATDDDSGVNGE-----ITYIV---NEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYIL 1914
Query: 327 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 386
++AE G ++ ILD N+ P F++ SY ++E+ PVG+T+ N+T
Sbjct: 1915 TVRAEDGGGQFTTI--RVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVL-VFNVT-- 1969
Query: 387 LRIVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 444
D +D + +L + D FTV + G+ L +L+ +DRE Q Y +
Sbjct: 1970 --------DADDGINSQLTYSIASGDSLGQFTVDKNGV---LKVLKALDRESQSFYNLVV 2018
Query: 445 TAFDGVQE-----SEPVIVNIQVMDANDNTPTF--PEISYDVYVYTDMRPGDSVI-QLTA 496
D Q + V+I ++D NDN PTF P+++Y + P D+V+ + A
Sbjct: 2019 QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY----IPENTPIDTVVFKAQA 2074
Query: 497 VDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 556
D D G N I Y +L F I G + + ++ Y LTV A D P+
Sbjct: 2075 TDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSL 2134
Query: 557 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 613
++ V + + NN P F Q +Y +EI+E G ++ + A D + + Y
Sbjct: 2135 SSSTEVVVMVLDINDNN---PIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRY 2191
Query: 614 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTD 672
I NG+ + F + TG +T+ K LDRE T Y L + A+D G T T+TV+IV+ D
Sbjct: 2192 GIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLD 2251
Query: 673 VNDNAPVFD--PY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 725
+ND PVF+ PY +P NL + + QV A D D G N ++ Y L GN +N
Sbjct: 2252 INDFVPVFELSPYSVNVPENLGTLPRT----ILQVVARDDDRGSNSKLSYVLFGGNEDNA 2307
Query: 726 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 785
F ++++G + L+RE ++ + L++ ATD T T+ + V D++DN P F +
Sbjct: 2308 FTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASK 2367
Query: 786 TYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 845
Y + E+ P GT +L + A D D N RI + F ++P TG++ LD
Sbjct: 2368 AYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ--FTINPSTGQIITSALLDR 2425
Query: 846 EAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 904
E + + T +V D P +T V V V D+ND PP F Y + +
Sbjct: 2426 ET----KDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLP 2481
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
G+ + V DAD P S + Y + + F ++ G ++ LN
Sbjct: 2482 GSFVFAVTVTDADIG--PNSELHYSLSGRN----SEKFHIDPLRGAIMAAGPLNGASEVT 2535
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY-----RPPPVSELATKGTMVG 1019
F + V D G + S TV + ++ + P+ +E PVS L T
Sbjct: 2536 FSVHVK--DGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTT----- 2588
Query: 1020 VISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1079
+ ++ + + Y I SGN +TF I+ +TG + ++ PLD+E YV+ ++A
Sbjct: 2589 ITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEA------- 2641
Query: 1080 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1139
+ P S+ K+ I + D N++ P+F++ +I + E+ +L V A DKD+G
Sbjct: 2642 RDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPN 2700
Query: 1140 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1199
+ Y ++ + + F + TG I++ + S++ + ++D S
Sbjct: 2701 GQLDYEIVNGNM---ENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSV 2757
Query: 1200 DVLVSVVNQLD-----MQVIVSNVP 1219
V+++++++ D Q+ ++VP
Sbjct: 2758 KVMINILDENDNAPRFSQIFSAHVP 2782
Score = 323 bits (828), Expect = 1e-87
Identities = 294/1103 (26%), Positives = 489/1103 (44%), Gaps = 113/1103 (10%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I V D ND+ P F + Y ++E P G+ + +G S ATD D G N + Y I
Sbjct: 463 IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV-SGIS----ATDGDSGLNANLRYSIVSG 517
Query: 195 PD---------------------DPDRAQ----NLNER------RTTTTTLTVDVLDGDD 223
D + A N++ R + + L V +LD +D
Sbjct: 518 NGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVND 577
Query: 224 LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283
P+F +P Y ++ E P ++ ++A D D D
Sbjct: 578 EKPVF-----------SQPEGYDVSVVE-NAPTGTELLM----LRATDGDLG-----DNG 616
Query: 284 GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG 343
+ +S+ E R F + P + LS + ++R+ + L++ A P + A
Sbjct: 617 TVRFSLQEA--ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMAR 674
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 403
+++ +LD N+ SP F Y +I E+ P G+ I+ + A D D+ +
Sbjct: 675 INVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---------VSATDPDLGTNGTVK 725
Query: 404 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQ 461
+ D + Q+G+ ++ +DREE+ Y I A DG +Q IV I
Sbjct: 726 YSISAGDRSRFQVNAQSGV---ISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTIT 782
Query: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFI 520
V+D DN P F +++Y V+ ++ G V ++A D SN I+Y I G Q G F
Sbjct: 783 VLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTGDQKGMFA 840
Query: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
IN+ TG +T A ++ Y L V A+ + +I + N + P F
Sbjct: 841 INQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDL------NDNSPHFL 894
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGK 637
Q + S+ + E + G + +A D + + Y+++ +P+ +F ++E G ++L
Sbjct: 895 QAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLG 953
Query: 638 ALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 697
LD + I I+ + G P +S+ + + V DVNDN+PVFD E N+
Sbjct: 954 PLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNS 1013
Query: 698 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 755
+V+A+D D+G NG++ Y++ GN + F I +G +Y +L+RE++D Y L+VVA+
Sbjct: 1014 RFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVAS 1073
Query: 756 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANV 815
D AV P +T+ + + + D++DN P+F ++ YT EE AG+ + ++ A D D G N
Sbjct: 1074 DRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNG 1133
Query: 816 SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--- 872
R V+ F LH +GE++ D E+ + + F +P +
Sbjct: 1134 EVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQ 1193
Query: 873 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRV 930
ATV V +KD+ND P F K Y+ ++ A T + V A D D GL +
Sbjct: 1194 ATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253
Query: 931 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 990
++ Q F ++ SG+V L+ E T + LV+ A D G ++S+ T+ I +L
Sbjct: 1254 EERQ-------FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDIL 1306
Query: 991 HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGIN 1046
+ + V E G +V ++A + N + YSI N TF I+
Sbjct: 1307 DENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSIS 1366
Query: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
TG I++ LD+ET++ Y L + A + P +S+T V I ++D N++PP
Sbjct: 1367 PNTGSIFLAKKLDFETQSLYKLNITA-------KDQGRPPRSSTMSVVIHVRDFNDNPPS 1419
Query: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
F + E+ + TSV+ V A D D ++Y II + G F ++ G
Sbjct: 1420 FPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPRGNH-FTIDEVKGT 1477
Query: 1167 IKTAMLFHNMRRSYFKFQVIATD 1189
I T + F+ V A D
Sbjct: 1478 IYTNAEIDREFANLFELTVKAND 1500
Score = 289 bits (740), Expect = 2e-77
Identities = 307/1131 (27%), Positives = 495/1131 (43%), Gaps = 140/1131 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDD-------- 181
EVR++VRD NDN+P F S T E + G + T D G+ +D
Sbjct: 120 EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRG 179
Query: 182 GPNGQIEYVIQYNPDDPDRAQNL------NERRTTTTTLTVDVLD-GDDLGPMFLPC-VL 233
G+ I NP +L + T L V+V D G+ +L V
Sbjct: 180 NEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVT 239
Query: 234 VPNTRDCRPLT----YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
V + D P+ YQA +PE + ++ + +Q D + +D I Y +
Sbjct: 240 VQDINDNPPVFGSSHYQAGVPE-------DAVVGSSVLQVAAADADEGTNAD---IRYRL 289
Query: 290 L-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIE 347
GTP F M P T +++ EP++ + +++ L ++A D G P L A I+
Sbjct: 290 QDEGTP------FQMDPETGLITVREPLDFEARRQYSLTVQA-MDRGVPSLTGRAEALIQ 342
Query: 348 ILDENNQSP-----YFTMPSYQGYILESAPVGATI---------SDSLNLTSPLRIVALD 393
+LD N+ P YF S + E+A VG + S + N ++I+ +
Sbjct: 343 LLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGN 402
Query: 394 K----DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 449
+ +++ +K P L L + + +DRE +Y +++ D
Sbjct: 403 EQRHFEVQSSKVPNLSL-------------------IKVASALDRERIPSYNLTVSVSDN 443
Query: 450 V---------QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 500
S + I V D ND+ P F + Y V + + PG V ++A D D
Sbjct: 444 YGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGD 503
Query: 501 EGSNGEITYEILVG-AQGDFIINKTTGLITI--APGVEMIVGRTYALTVQAADNAPPAER 557
G N + Y I+ G G F I++ +GL+T + G++ + L + A D
Sbjct: 504 SGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQG--VHP 561
Query: 558 RNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GD--SITYA 614
+ S + + +L N++ P Y + + E G LL L+ATD + GD ++ ++
Sbjct: 562 KVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFS 621
Query: 615 IENGD-PQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTD 672
++ + +R F L +G L+ +LDRE Y L++ A+D G P +S A +N+ + D
Sbjct: 622 LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Query: 673 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 730
+NDN+PVF P E +++ V ATDPD G NG V YS+ G+ +
Sbjct: 682 INDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQ 741
Query: 731 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 790
+G I T + L+RE + Y+L +VATDG + + I VLD DN PVF+ Y+ +
Sbjct: 742 SGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Query: 791 VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 850
V EN+ G + + A +DL +N+SY I + + K FA++ TG+L+ + D
Sbjct: 802 VFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVI------D 855
Query: 851 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 910
+E + ++ GT+ G V + VKD+ND P F + I V + G I
Sbjct: 856 REEQSFYQLKVVASGGTV-TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSI-- 912
Query: 911 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 970
A+ DP V Y + P ++F + E +G + L+ + +++ ++
Sbjct: 913 FQAKAVDPDEGVNGMVLYSLKQ----NPKNLFAINEKNGTISLLGPLDVHAGS-YQIEIL 967
Query: 971 AFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AA 1025
A D G P +SSS + + V + P F Q Y +SE + + A +
Sbjct: 968 ASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE-VTLSESEPVNSRFFKVQASDKDSG 1026
Query: 1026 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1085
N I Y+I GN D FGI G +Y+ LD E + YVL VV ++ V
Sbjct: 1027 ANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLM-------VVASDRAVE 1078
Query: 1086 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1145
S T V + ++D N++ P+F Y E+ R + V +V A DKD G + Y
Sbjct: 1079 PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYS 1138
Query: 1146 L-IIPPIKEGKEGFVVETYTGLIKTAMLFHN---MRR---SYFKFQVIATD 1189
++ P F + +G I F MRR + F F VIATD
Sbjct: 1139 FEMVQP------DFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATD 1183
Score = 287 bits (734), Expect = 8e-77
Identities = 303/1110 (27%), Positives = 481/1110 (43%), Gaps = 117/1110 (10%)
Query: 91 KQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE---VRIVVRDRNDNSPTF 147
K + +N + P+++H+ Q++ + +G + + V D NDNSP F
Sbjct: 937 KNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVF 996
Query: 148 KHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI-QYNPDD-----PDR- 200
SY T++E PV + F A+D D G NG+I Y I + N D PD
Sbjct: 997 DQLSYEVTLSESEPVNSRFF-----KVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQ 1051
Query: 201 ---AQNLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 255
L+ L V D + L V++ + D RPL + +
Sbjct: 1052 LYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPL-FNSTNYTFYFE 1110
Query: 256 EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEP 315
EE + A+D+D P + + YS + P+ F +H + E++
Sbjct: 1111 EEQRAGSFVGKVSAVDKD--FGPNGE---VRYSFEMVQPD-----FELHAISGEITNTHQ 1160
Query: 316 VNRDFHQK------FDL-VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 368
+R+ + F VI +Q PL A +H+ + D N+ +P F YQ I
Sbjct: 1161 FDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATIS 1220
Query: 369 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 428
ESA NLT LR+ A D D + + + F + T + +TL
Sbjct: 1221 ESA---------ANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDST--SGQVTL 1269
Query: 429 LQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 486
+ +D E Y+ I A D + + +NI ++D NDNTP+FP+ + V V +MR
Sbjct: 1270 IGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMR 1329
Query: 487 PGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 545
G+ V +TA D+D G N ++ Y I G F I+ TG I +A ++ Y L
Sbjct: 1330 IGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLN 1389
Query: 546 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 605
+ A D P R+S +V I V N +PP FP I E + +G ++++ A D
Sbjct: 1390 ITAKDQGRPP--RSSTMSVVIHV-RDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHD 1446
Query: 606 REGD---SITYAIENGDPQ-RVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 660
+ D ++Y I P+ F + E G + +DRE + + L + A+D P
Sbjct: 1447 PDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIE 1506
Query: 661 T---STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQV 715
T + V I+VTD+NDN P+F + +N + A + + + A DPD G NG++
Sbjct: 1507 TRRYALKNVTILVTDLNDNVPMF---ISQNALAADPSAVIGSVLTTIMAADPDEGANGEI 1563
Query: 716 HYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 773
Y + G+ + +G + A L + Y L+V ATD R ST L I +
Sbjct: 1564 EYEIINGDTDTFIVDRYSGDLRVASALVPS-QLIYNLIVSATDLGPERRKSTTELTIILQ 1622
Query: 774 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN-------VSYRIRSPEVKH 826
+D PVFT Y +++E P GT ++ IEA G+ VS R V
Sbjct: 1623 GLD--GPVFTQPKYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGR 1679
Query: 827 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGI--ATVTVIVKDMN 883
F + TG + LD E + + +LV+ + I T P A V + ++D+N
Sbjct: 1680 LFTIGRHTGIIQTAAILDRE-----QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDIN 1734
Query: 884 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD--PPGLPASRVRYRVDDVQFPYPASI 941
D PPVF + V + G+ I + A DAD L + DD
Sbjct: 1735 DNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADD--------S 1786
Query: 942 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1000
F ++ +SG +I L+ E + + L+V A DDG + SS + I V + P+F++
Sbjct: 1787 FRIDPESGDLIATRRLDRERRSKYSLLVRA-DDG--LQSSDMRINITVSDVNDHTPKFSR 1843
Query: 1001 EEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1056
Y + E G++V I A + +N I Y + +E+ F +N ITGV +
Sbjct: 1844 PVY-SFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTR 1902
Query: 1057 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1116
LDYE + Y+L V+A+ + T +VY I D N++PP+F Y +
Sbjct: 1903 LLDYEVQQYYILTVRAED---------GGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSL 1953
Query: 1117 SEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
E+ + ++VL TD D G S + Y +
Sbjct: 1954 MENLPVGSTVLVFNVTDADDGINSQLTYSI 1983
Score = 283 bits (724), Expect = 1e-75
Identities = 267/925 (28%), Positives = 409/925 (44%), Gaps = 83/925 (8%)
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD-KDIEDTKDP 402
+ + + D N+ +P F PS E + G + S + +D + +
Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180
Query: 403 ELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP----- 455
E F D T+ +G +L L+ +DRE Y + D + EP
Sbjct: 181 EAGRFRLD----ITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGY 233
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
+ VN+ V D NDN P F Y V D G SV+Q+ A DADEG+N +I Y L
Sbjct: 234 LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDE 292
Query: 516 QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 575
F ++ TGLIT+ ++ R Y+LTVQA D P+ I++L N+
Sbjct: 293 GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEALIQLLDVNDND 350
Query: 576 P----PRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLS 627
P FP + E +VG V+ L TD + +I+ I G+ QR F +
Sbjct: 351 PVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQ 410
Query: 628 ET----TGILTLGKALDRESTDRYILIITASD--GRPDG------TSTATVNIVVTDVND 675
+ ++ + ALDRE Y L ++ SD G P G +S A++ I V D+ND
Sbjct: 411 SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 676 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGS 733
+ PVF + R E ++V + ATD D+G+N + YS+ + N L F I+ +
Sbjct: 471 HPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530
Query: 734 IYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 789
+ T L+RE+ L + A D VHP+ S L + +LD++D PVF+ Y V
Sbjct: 531 LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590
Query: 790 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSLLRSLDYE 846
V EN P GT +L + A D DLG N + R E + F L P +G LS + SLD E
Sbjct: 591 SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
++A + LV A D+ +A + V + D+ND PVF Y + + G+
Sbjct: 651 ----EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGS 706
Query: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
ITTV A D D V+Y + S F+V SG + TR+ L+ E T ++
Sbjct: 707 YITTVSATDPDLG--TNGTVKYSIS----AGDRSRFQVNAQSGVISTRMALDREEKTAYQ 760
Query: 967 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1025
L +VA D G + A V I VL + P + V E G VG +SA+
Sbjct: 761 LQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTM 820
Query: 1026 -INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1084
+N +I Y I +G+++ F IN +TG + +D E ++ Y L+V A V
Sbjct: 821 DLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV------- 873
Query: 1085 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1144
+ V I ++D N++ P F + V E+ + S+ + KA D D G ++ Y
Sbjct: 874 ---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLY 930
Query: 1145 RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV- 1203
L P K F + G I ++ ++ +++A+D LS + V
Sbjct: 931 SLKQNP----KNLFAINEKNGTISLLGPL-DVHAGSYQIEILASDMGVPQLSSSVILTVY 985
Query: 1204 --------SVVNQLDMQVIVSNVPP 1220
V +QL +V +S P
Sbjct: 986 VHDVNDNSPVFDQLSYEVTLSESEP 1010
Score = 278 bits (711), Expect = 4e-74
Identities = 261/971 (26%), Positives = 431/971 (44%), Gaps = 78/971 (8%)
Query: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 326
+ A+D+D D Y I+ G E+ F ++ T E+ + P++R+ + L
Sbjct: 2690 VSAMDKDSGPNGQLD-----YEIVNGNMENS---FSINHATGEIRSVRPLDREKVSHYVL 2741
Query: 327 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 386
IK+ + I ILDEN+ +P F+ + ++ E++P+G T++
Sbjct: 2742 TIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVT-------- 2792
Query: 387 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 446
R+ D+DI + D + FT+ + T + + +P++RE+ Y ++A
Sbjct: 2793 -RVTTSDEDIGINAISRYSIM--DASLPFTINPS--TGDIVISRPLNREDTDRYRIRVSA 2847
Query: 447 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 506
D + V I V D NDN P F SY + G V Q+ A D DEGSNG+
Sbjct: 2848 HDSGW-TVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQ 2906
Query: 507 ITYEILVGAQGDFI-INKTTGLI--------TIAPGVEMIVGRTYALTVQAADNAPPAER 557
+ Y + +Q ++ IN TTG I G + ++ V ++D P+
Sbjct: 2907 VFY--FIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLI 2964
Query: 558 RNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITY 613
+ T+ I +N + P+F + Y +++ ++VG L+ + A D + + Y
Sbjct: 2965 SETTVTINIV---DSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEY 3021
Query: 614 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTD 672
I N + F L TG +++ +L + + + +TA D G P +S ATV+I VT+
Sbjct: 3022 FISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTE 3081
Query: 673 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 730
N + P F + V V A D DA +NG + YS+ GN +F I S
Sbjct: 3082 ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINS 3141
Query: 731 NGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 789
+ I T K L+ E+ +E+ + A DG R ++ + V+D++DNSPVF + Y
Sbjct: 3142 STGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFP 3201
Query: 790 LVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 847
V EN P+GTT++ + A D D G N ++Y ++S + F + P TG ++ LD+E
Sbjct: 3202 TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET 3260
Query: 848 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 907
+ S V+AF++ ATV + +K N+Y P F ++Y ++ A KGT
Sbjct: 3261 ----KQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTI 3316
Query: 908 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 967
+ V+A D D V Y + F++ + +G++ L+ E L
Sbjct: 3317 VGEVFASDRDLG--TDGEVHYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSL 3371
Query: 968 VVVA--FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA 1025
V+A F TV + VL + P FT Y +SE GT V +SA
Sbjct: 3372 KVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFD 3430
Query: 1026 IN-----QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
+ Y I SGNE F IN TG I V LD ET Y +L V+
Sbjct: 3431 SDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAV 3483
Query: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNY 1139
+ PS + +A + + ++D N++ P+ G V E+ R T V+ +++TD D N
Sbjct: 3484 DSGTPSATGSASLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQ 3541
Query: 1140 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1199
Y L+ F + T G++ T + + F V+ D +S
Sbjct: 3542 GPFTYYLL--STGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTG 3598
Query: 1200 DVLVSVVNQLD 1210
V ++V++Q D
Sbjct: 3599 TVHITVIDQND 3609
Score = 254 bits (649), Expect = 6e-67
Identities = 275/1034 (26%), Positives = 459/1034 (44%), Gaps = 133/1034 (12%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Y ++ I V D NDN+P FK + + + + E L+P I T A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704
Query: 189 YVI-------------------QYNPDDPDRAQNL----------NERRTTTTTLTVDVL 219
Y I P D ++ + + ++T+ + +++L
Sbjct: 2705 YEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINIL 2764
Query: 220 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 279
D +D P F + A +PE +P VT D+D I
Sbjct: 2765 DENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----DEDIGINAI 2806
Query: 280 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 339
S YSI+ D F ++P T ++ + P+NR+ ++ + + A D+G +
Sbjct: 2807 SR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH-DSGWTVS 2855
Query: 340 AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDT 399
+ I + D N+ +P F+ SY E +G+ ++ ++ A D D +
Sbjct: 2856 T--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFATDPD--EG 2902
Query: 400 KDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQTYTFSITAFDGVQES 453
+ ++ F+ + F + T + + Q V ++F +T+ D + S
Sbjct: 2903 SNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPS 2962
Query: 454 --EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 510
V I ++D+NDN P F + Y V +++ G +I++TA+D D G N E+ Y
Sbjct: 2963 LISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYF 3022
Query: 511 ILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
I G F ++ TG I++A + + + + +TV A D P +S TV+I V
Sbjct: 3023 ISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQATVHITVT 3080
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNL 626
N +P F Q S I E+ +G+++ + A DR+ I Y+I +G+ + +F +
Sbjct: 3081 EENYHTP-EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAI 3139
Query: 627 SETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVF--D 681
+ +TGILTL KALD E ++ + I+A DG G + TVN++ DVNDN+PVF D
Sbjct: 3140 NSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVNDNSPVFLSD 3197
Query: 682 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-GSIYTAVK 739
Y P L + V + ATD D+G N + Y++ + ++LF I N G I T
Sbjct: 3198 DYFPTVLE--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGF 3255
Query: 740 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 799
L+ E + Y L V A + R S T+ I++ ++ P F + Y + E P GT
Sbjct: 3256 LDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGT 3315
Query: 800 TILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 857
+ ++ A D DLG + V Y I K F ++ TG++ + LD E ++ S+
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK--EERVSLKV 3373
Query: 858 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917
L + F TV V V D ND PP+F+ IY ++ GT +T V A D+D
Sbjct: 3374 LAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSD 3432
Query: 918 PPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 976
+P+ SR Y + F + +G++ L+ E I+ L V+A D G
Sbjct: 3433 --SIPSWSRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT 3487
Query: 977 PVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQS-I 1030
P + SA++ + + + P T E V E GT+V + + NQ
Sbjct: 3488 PSATGSASLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMTLQSTDPDLPPNQGPF 3544
Query: 1031 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1090
Y ++S ++ + GV+ +D E + L VV + VP S+T
Sbjct: 3545 TYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL-------SVVTKDSGVPQMSST 3597
Query: 1091 AKVYIEIQDENNHP 1104
V+I + D+N++P
Sbjct: 3598 GTVHITVIDQNDNP 3611
Score = 240 bits (613), Expect = 8e-63
Identities = 291/1148 (25%), Positives = 478/1148 (41%), Gaps = 152/1148 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + ++D NDN+P F + Y AT++E T + A+D+D+G NG I Y I
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV-----SASDVDEGNNGLIHYSII 1250
Query: 193 YNPDDPDRAQNLNERRTT-----------------------------TTTLTVDVLDGDD 223
++ A + + T T TL +D+LD +D
Sbjct: 1251 KGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDEND 1310
Query: 224 LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283
P F L + + +R E ++ + T D D D
Sbjct: 1311 NTPSFPKSTL-----------FVDVLENMRIGELVSSVTAT------DSDSG-----DNA 1348
Query: 284 GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG 343
+ YSI T + F + P T + L + ++ + + L I A+ P +
Sbjct: 1349 DLYYSI---TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMS 1405
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 403
+ I + D N+ P F I+E+ P+G TS + + A D D +
Sbjct: 1406 VVIHVRDFNDNPPSFPPGDIFKSIVENIPIG---------TSVISVTAHDPDADINGQLS 1456
Query: 404 LHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP-----VI 457
+ + FT+ + T Y +DRE + ++ A D E
Sbjct: 1457 YTIIQQMPRGNHFTIDEVKGTIYTNA--EIDREFANLFELTVKANDQAVPIETRRYALKN 1514
Query: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ-LTAVDADEGSNGEITYEILVGAQ 516
V I V D NDN P F IS + SV+ + A D DEG+NGEI YEI+ G
Sbjct: 1515 VTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT 1572
Query: 517 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 576
FI+++ +G + +A + + Y L V A D P + + T+ ++ L
Sbjct: 1573 DTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQGL-----DG 1626
Query: 577 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-------ITYAIENGDPQRVFNLSET 629
P F Q Y + E +G +++++A G ++ E R+F +
Sbjct: 1627 PVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRH 1686
Query: 630 TGILTLGKALDRESTDRYILI----ITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLP 685
TGI+ LDRE L+ I S P T A V I + D+NDN PVF P
Sbjct: 1687 TGIIQTAAILDREQGACLYLVDVYAIEKSTAFP-RTQRAEVEITLQDINDNPPVF-PTDM 1744
Query: 686 RNLSVVEEEAN-AFVGQVKATDPDAGINGQVHYS-LGNFNNLFRI-TSNGSIYTAVKLNR 742
+L+V E + + + Q+ A D D G N V Y+ + ++ FRI +G + +L+R
Sbjct: 1745 LDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDR 1804
Query: 743 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802
E R Y L+V A DG + S + + I V D++D++P F+ Y+ + E+ G+ +
Sbjct: 1805 ERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVA 1861
Query: 803 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 860
I A D D G N ++Y + + F L+P TG +L R LDYE + V
Sbjct: 1862 AILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV----QQYYILTVR 1917
Query: 861 AFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 918
A D G T+ V + D+ND PP+FS Y + + G+ + DAD
Sbjct: 1918 AEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD- 1972
Query: 919 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEP 977
G+ S++ Y + S+ + D V+ + L+ E + + LVV D +
Sbjct: 1973 DGI-NSQLTYSIASGD-----SLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQI 2026
Query: 978 VMS---SSATVKILVLHPGE-IPRFTQEE--YRP--PPVSELATKGTMVGVISAAAINQS 1029
S S+A V I++L + P F + Y P P+ + K S N
Sbjct: 2027 PASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGP--NSY 2084
Query: 1030 IVYSIVS--GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1087
I Y++++ GN+ F I I G + + G LD E ++Y +L VV + PS
Sbjct: 2085 IEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNY-------TLTVVATDKGQPSL 2134
Query: 1088 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
S++ +V + + D N++ P+F + Y ++E+ T +++V A D D G + Y ++
Sbjct: 2135 SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIV 2194
Query: 1148 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1207
+ F +++ TG I A + + V ATD +G + + D +
Sbjct: 2195 ---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD---RGSTPRTDTSTVSIV 2248
Query: 1208 QLDMQVIV 1215
LD+ V
Sbjct: 2249 LLDINDFV 2256
Score = 237 bits (604), Expect = 9e-62
Identities = 279/1065 (26%), Positives = 448/1065 (42%), Gaps = 94/1065 (8%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
Y +V + V+D NDN P F Y A V E VG+++ A D D+G N I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287
Query: 190 VIQYNPD----DPDRA-----QNLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTR 238
+Q DP+ + L+ +LTV +D L + + +
Sbjct: 288 RLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVN 347
Query: 239 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 298
D P+ P ++ + A+ + P+ I IL G +
Sbjct: 348 DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQ--- 404
Query: 299 RFFHMH----PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-------FAGLHIE 347
R F + P + + + ++R+ ++L + + G P A A L I
Sbjct: 405 RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIF 464
Query: 348 ILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 407
+ D N+ P F+ Y+ + E AP G+ +S I A D D + +
Sbjct: 465 VNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG---------ISATDGDSGLNANLRYSIV 515
Query: 408 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI----VNIQVM 463
+ F +++ +DRE +I+A D Q P + + + ++
Sbjct: 516 SGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARD--QGVHPKVSYAQLVVTLL 573
Query: 464 DANDNTPTF--PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD--- 518
D ND P F PE YDV V + G ++ L A D D G NG + + L A+ D
Sbjct: 574 DVNDEKPVFSQPE-GYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFS-LQEAETDRRS 631
Query: 519 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
F ++ +G ++ ++ Y+L V A D P + +S+ + + +L N+ SP
Sbjct: 632 FRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQ--SSMARINVSLLDINDNSPVF 689
Query: 579 FPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTL 635
+P + Y I E G+ + + ATD + ++ Y+I GD R F ++ +G+++
Sbjct: 690 YP-VQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSR-FQVNAQSGVIST 747
Query: 636 GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 694
ALDRE Y L I A+D G + A V I V D DN PVF + + V E
Sbjct: 748 RMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFS-QVAYSFVVFENV 806
Query: 695 ANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVV 752
A + VG V A+ D N + G+ +F I G + TA ++RE + +Y+L V
Sbjct: 807 ALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKV 866
Query: 753 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 812
VA+ G V + I V D++DNSP F + +V V EN AG +I Q +A D D G
Sbjct: 867 VASGGTV---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEG 923
Query: 813 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 870
N V Y ++ K+ FA++ G +SLL LD A S + A D+
Sbjct: 924 VNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLDVHA-----GSYQIEILASDMGVPQLS 977
Query: 871 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 930
+TV V D+ND PVF + Y+ ++ + V A D D + Y +
Sbjct: 978 SSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGA--NGEIAYTI 1035
Query: 931 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 990
+ IF G++ + L+ E + L+VVA D +S++ V +++
Sbjct: 1036 AEGNTGDAFGIF----PDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILE 1091
Query: 991 HPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGI 1045
+ P F Y E G+ VG +SA N + YS + F +
Sbjct: 1092 DVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM--VQPDFEL 1148
Query: 1046 NNITGVIYVNGPLDYETRTSYVLR--VQADSLEVVLANLRVPSK-SNTAKVYIEIQDENN 1102
+ I+G I D R S + R S V+ + +P + A V++ ++D N+
Sbjct: 1149 HAISGEITNTHQFD---RESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDIND 1205
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
+ P F K FY +SE A T VLRV A+D D GN ++ Y +I
Sbjct: 1206 NAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSII 1250
Score = 218 bits (554), Expect = 6e-56
Identities = 229/864 (26%), Positives = 362/864 (41%), Gaps = 116/864 (13%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
+ + +MD STG ++ P + +++ G + +V I V D
Sbjct: 2806 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865
Query: 141 NDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD---- 196
NDN+P F SYY ELT +G+ + F ATD D+G NGQ+ Y I+ +
Sbjct: 2866 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF-----ATDPDEGSNGQVFYFIKSQSEYFRI 2920
Query: 197 ----------------DPDRAQNLNERR---------------TTTTTLTVDVLDGDDLG 225
+ N+N R + TT+T++++D +D
Sbjct: 2921 NATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980
Query: 226 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ--AIDQDRNIQPPSDRP 283
P FL + TP N + T I+ AID D++ S+
Sbjct: 2981 PQFLK-------------------SKYFTPVTKNVKVGTKLIRVTAID-DKDFGLNSE-- 3018
Query: 284 GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG 343
+ Y I + +++ F + T +S+ + D +Q F + + A+ PL + A
Sbjct: 3019 -VEYFI---SNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQAT 3074
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 403
+HI + +EN +P F+ I ES +G+ + + A D+D +
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR---------TVSARDRDAAMNGLIK 3125
Query: 404 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQ 461
+ + +F + + T LTL + +D E Q + +I+A DG V + V +
Sbjct: 3126 YSISSGNEEGIFAINSS--TGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVN 3183
Query: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 521
V+D NDN+P F Y V + G +VI L A DAD G+N I Y + F+I
Sbjct: 3184 VIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVI 3243
Query: 522 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 581
+ TG+IT ++ ++Y LTV+A + P E R S TV I+ L N+ PRF
Sbjct: 3244 DPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQ-LKGTNEYVPRFVS 3300
Query: 582 LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKA 638
+Y EISEA G ++ + A+DR+ + Y I ++ F +++ TG + +
Sbjct: 3301 KLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI 3360
Query: 639 LDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
LDRE +R L + A + R TVN+ V D ND P N+ V+
Sbjct: 3361 LDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-----PPIFTLNIYSVQISE 3415
Query: 696 NAFVGQ----VKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVKLNREVRD 746
+G V A D D+ I +S GN N F I G I +L+RE
Sbjct: 3416 GVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLP 3474
Query: 747 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 806
Y L V+A D + +L + + DI+DN P+ T S V+ EN GT ++ +++
Sbjct: 3475 IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPGTLVMTLQS 3532
Query: 807 KDVDLGAN----VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 862
D DL N Y + + +F+L G LS R +D E D S+
Sbjct: 3533 TDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVV----TK 3587
Query: 863 DIYGTMPPGIATVTVIVKDMNDYP 886
D TV + V D ND P
Sbjct: 3588 DSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 216 bits (550), Expect = 2e-55
Identities = 244/842 (28%), Positives = 373/842 (44%), Gaps = 76/842 (9%)
Query: 408 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 467
L++ ++F + + Y T +DRE + ++ + P V + V D ND
Sbjct: 74 LSESHALFAINSSTGALYTT--STIDRESLPSDVINLVVLSSAP-TYPTEVRVLVRDLND 130
Query: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--EITYEILVGAQ-GDFIINKT 524
N P FP+ S V D G VI TA D+D GSNG +Y I+ G + G F ++ T
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190
Query: 525 TG--------LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 576
+ G++ V Y L V+ D P R V ++ + N +P
Sbjct: 191 LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI---NDNP 247
Query: 577 PRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSETTGILTL 635
P F Y + E VG+ +L + A D EG + D F + TG++T+
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITV 307
Query: 636 GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEE 693
+ LD E+ +Y L + A D G P T A I + DVNDN PV Y P
Sbjct: 308 REPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASV 367
Query: 694 EANAFVGQVKA----TDPDA-GINGQVHYSL--GNFNNLFRITSN-----GSIYTAVKLN 741
+ NA VG V A TD D+ NG + + GN F + S+ I A L+
Sbjct: 368 DENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALD 427
Query: 742 REVRDYYELVVVATD-------GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 794
RE Y L V +D AV R S +L I V DI+D+ PVF+ Y V + E
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487
Query: 795 LPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPD 850
P G+ + I A D D L AN+ Y I S +F + +G ++ S LD E
Sbjct: 488 APPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL--- 544
Query: 851 QEASITFLVEAFDIYGTMPP-GIATVTVIVKDMNDYPPVFSK-RIYKGMVAPDAVKGTPI 908
+ I + A D G P A + V + D+ND PVFS+ Y V +A GT +
Sbjct: 545 -ASQIVLNISARD-QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602
Query: 909 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 968
+ A D D VR+ + + + + F ++ SGR+ T +L+ E + L+
Sbjct: 603 LMLRATDGDLG--DNGTVRFSLQEAETDRRS--FRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 969 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA--- 1024
V+A D G P SS A + + +L + P F +Y + E G+ + +SA
Sbjct: 659 VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPD 717
Query: 1025 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1083
N ++ YSI +G + F +N +GVI LD E +T+Y L++ A NL+
Sbjct: 718 LGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD----GGNLQ 772
Query: 1084 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1143
P N A V I + D ++PPVF + Y V E+ + V V A+ D S ++
Sbjct: 773 SP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNIS 827
Query: 1144 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1203
Y LI ++G F + TG + TA + +S+++ +V+A+ G ++G V +
Sbjct: 828 Y-LITTGDQKGM--FAINQVTGQLTTANVIDREEQSFYQLKVVAS---GGTVTGDTMVNI 881
Query: 1204 SV 1205
+V
Sbjct: 882 TV 883
Score = 172 bits (436), Expect = 3e-42
Identities = 186/645 (28%), Positives = 296/645 (45%), Gaps = 61/645 (9%)
Query: 601 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 660
L T + TY + + +F ++ +TG L +DRES ++ + P
Sbjct: 60 LVGTIQTRPGFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP-- 115
Query: 661 TSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQVH 716
T V ++V D+NDNAPVF DP ++ V +E ++ QV ATD D G NG H
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVDH 171
Query: 717 YSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPRH 763
S GN FR IT N S + + L+REV Y+L+V D R
Sbjct: 172 RSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRR 231
Query: 764 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 823
L + + V DI+DN PVF +S Y V E+ G+++LQ+ A D D G N R R +
Sbjct: 232 GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD 291
Query: 824 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 883
F + P TG +++ LD+EA ++ S+T V+A D G A + + D+N
Sbjct: 292 EGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDVN 347
Query: 884 DYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFPY 937
D PV R + V +A GT + + DAD P + V+ + Q +
Sbjct: 348 DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF 407
Query: 938 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHPG 993
+V S + L+ E + L V D+ G P + + ++V LV+
Sbjct: 408 EVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVN 466
Query: 994 EI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGI 1045
+I P F+Q+ YR +SE A G+ V ISA + +N ++ YSIVSGN F I
Sbjct: 467 DINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 1046 NNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
+ +G++ +G LD E + VL + A + V K + A++ + + D N+
Sbjct: 526 SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVNDE 578
Query: 1104 PPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
PVF Q + Y V E+A T +L ++ATD D G+ + R + + + F ++
Sbjct: 579 KPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLDP 636
Query: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1207
+G + T ++++ V+ATD S A + VS+++
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Score = 165 bits (417), Expect = 5e-40
Identities = 189/731 (25%), Positives = 310/731 (42%), Gaps = 61/731 (8%)
Query: 109 MNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
+N HS +V K I V I + D NDN+P F Y+ V + VGT +
Sbjct: 2946 INRHSFIV-TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG--DDLGP 226
+ D D D G N ++EY I + +L + + T + V DL
Sbjct: 3005 VTAID----DKDFGLNSEVEYFISND-------NHLGKFKLDNDTGWISVASSLISDLNQ 3053
Query: 227 MFLPCVLVPNTRDCRPLTYQAAI------PELRTPE--ELNPIIVTPPIQAIDQDRNIQP 278
F V + + PL+ QA + TPE + + P +I
Sbjct: 3054 NFFITVTAKD-KGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVS 3112
Query: 279 PSDRPG-----ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 333
DR I YSI G E F ++ T L+L + ++ + QK ++ I A
Sbjct: 3113 ARDRDAAMNGLIKYSISSGNEEG---IFAINSSTGILTLAKALDYELCQKHEMTISAIDG 3169
Query: 334 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
+ + + ++D N+ SP F Y +LE+AP G T+ + + A D
Sbjct: 3170 GWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTV---------IHLNATD 3220
Query: 394 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 453
D T + + + +F + T +T +D E +Q+Y ++ AF+ E
Sbjct: 3221 AD-SGTNAVIAYTVQSSDSDLFVIDPN--TGVITTQGFLDFETKQSYHLTVKAFNVPDEE 3277
Query: 454 EP--VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 511
VNIQ+ N+ P F Y + G V ++ A D D G++GE+ Y I
Sbjct: 3278 RCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLI 3337
Query: 512 LVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 570
+ + F INK TG I ++ ++ +L V A + TV + VL
Sbjct: 3338 FGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLD 3397
Query: 571 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG----DSITYAIENGDPQRVFNL 626
N+ PP F +YS++ISE + +G + + A D + +Y I +G+ F++
Sbjct: 3398 AND--PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSI 3455
Query: 627 SETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP 685
+ TG +T+ LDRE+ Y L + A D G P T +A++ + + D+NDN P+ +
Sbjct: 3456 NPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT--VS 3513
Query: 686 RNLSVVEEEANAFVGQVKATDPDAGIN-GQVHY---SLGNFNNLFRITSNGSIYTAVKLN 741
+ + V +++TDPD N G Y S G + F +++ G + T +++
Sbjct: 3514 EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREID 3573
Query: 742 RE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
RE + D+Y L VV D V ST T+ I V+D +DN V NL G
Sbjct: 3574 REQIADFY-LSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGI 3632
Query: 801 ILQIEAKDVDL 811
+ ++ +D D+
Sbjct: 3633 LGSVKPQDPDV 3643
Score = 139 bits (351), Expect = 2e-32
Identities = 174/701 (24%), Positives = 282/701 (40%), Gaps = 111/701 (15%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V + N ++P F AT+ E +G+ + T A D D NG I+Y I
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-----SARDRDAAMNGLIKYSIS 3129
Query: 193 YNPDDPDRAQNLNE-----------------------------RRTTTTTLTVDVLDGDD 223
++ A N + RT ++TV+V+D +D
Sbjct: 3130 SGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVND 3189
Query: 224 LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283
P+FL P + P + ++ +Q+ D D
Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD---------- 3239
Query: 284 GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG 343
F + P T ++ ++ + Q + L +KA +FA
Sbjct: 3240 ----------------LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFAT 3283
Query: 344 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 403
++I++ N P F Y I E+AP G + + + A D+D+ +
Sbjct: 3284 VNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE---------VFASDRDLGTDGEVH 3334
Query: 404 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQ--ESEPVIVN 459
+F N F + + Y++ + +DRE+++ + + A F ++ + + V VN
Sbjct: 3335 YLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLAKNFGSIRGADIDEVTVN 3392
Query: 460 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE-GSNGEITYEILVGAQ-G 517
+ V+DAND P F Y V + + G V ++A D+D S +Y I G + G
Sbjct: 3393 VTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENG 3451
Query: 518 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 577
F IN TG IT+ ++ Y L+V A D+ P+ ++ V +E + N
Sbjct: 3452 AFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNG---- 3507
Query: 578 RFPQLMYSL-EISEAMRVGAVLLNLQATD-----REGDSITYAIENGDPQRVFNLSETTG 631
P L S E+ E R G +++ LQ+TD +G Y + G F+LS T G
Sbjct: 3508 --PMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS-TAG 3564
Query: 632 ILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 690
+L+ + +DRE D Y+ ++T G P +ST TV+I V D NDN P R + +
Sbjct: 3565 VLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-----PSQSRTVEI 3619
Query: 691 -VEEEANAF----VGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTAVKLNREV 744
V N F +G VK DPD + H SL +LF I G R
Sbjct: 3620 FVNYYGNLFPGGILGSVKPQDPD--VLDSFHCSLTSGVTSLFSIP--GGTCDLNSQPRST 3675
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 785
++L V++ DG HST+T I+V ++ NS
Sbjct: 3676 DGTFDLTVLSNDGV----HSTVTSNIRVFFAGFSNATVDNS 3712
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 318 bits (814), Expect = 4e-86
Identities = 321/1195 (26%), Positives = 531/1195 (44%), Gaps = 128/1195 (10%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD- 217
PVGT++ T A+D D G NG I Y I P +TT L +
Sbjct: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFES 538
Query: 218 -------VLDGDDLGPMFL------PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVT 264
++ D G + + + N D PL + A + + + +T
Sbjct: 539 SPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHIT 598
Query: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
+ AID D + + Y I+ G FF+++P + L L + + +
Sbjct: 599 -AVSAIDID-------ELELVKYKIISGNELG---FFYLNPDSGVLQLKKSLTNSGIKNG 647
Query: 325 DLVIKAEQDNGHPLPAFAGLHIEILD---------------------------------- 350
+ ++ +G L ++I +L
Sbjct: 648 NFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLN 707
Query: 351 -ENNQSPYFTMPSYQGYILESAPVGATISDSLNL-TSPLRIVALDKDIEDTKDPELHLFL 408
E+ ++++ Y +S P + + L + + L+I A D D +
Sbjct: 708 LEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISD 767
Query: 409 NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 466
+ S F + T L +L P+DRE Y +IT +D Q+S ++ I V DAN
Sbjct: 768 GNTDSCFNIDME--TGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825
Query: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTG 526
DN+P F + SY V + G +IQ+ A D D GSNGE+TY +L Q F IN +TG
Sbjct: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ-QFAINSSTG 884
Query: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
++ +A ++ Y+L ++A D A ++ S+ T+ + + N+ SP P YS+
Sbjct: 885 IVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPS-SYSV 943
Query: 587 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
++ E + VG V+ L+ D + G + Y++ N D F + + +G + L K LD E
Sbjct: 944 KVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEK 1002
Query: 644 TDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG- 700
Y L + A D GRP S+ + V + V DVN+N + PY P V + N+ +G
Sbjct: 1003 QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN--LHTPYFPDFAVVGSVKENSRIGT 1060
Query: 701 ---QVKATDPDAGINGQVHYSLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVA 754
QV A D D+G +G++ YS+ + + L R + +G I A L+RE Y L V A
Sbjct: 1061 SVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
Query: 755 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 814
TD V P +ST+ + I+V D++DN+P+ + Y +V EN P +++QI+A+D D +N
Sbjct: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
Query: 815 --VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPG 871
++YRI S ++FFA++ TG ++ R LD E Q+A V D G P
Sbjct: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE----QQAEHFLEVTVTD--GGPSPK 1234
Query: 872 IATVTVIVK--DMNDYPPVFSKRIYKGMVAPD---AVKGTPITTVYAEDADPPGLPASRV 926
+T+ V+V+ D ND P F +++Y+ + P+ +G PI +A D D P + +
Sbjct: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERDRKKRGEPIYRAFAFDRDEG--PNAEI 1291
Query: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
Y + D F ++ +G V +R I L + A D+G P SS+A +
Sbjct: 1292 SYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTARLH 1346
Query: 987 ILVLH---PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
I + P IP E + V E +VGV+S N + + IV GN + F
Sbjct: 1347 IEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAF 1406
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
G I + PLD E R+ Y + V+ D V + +V+I++ D N+
Sbjct: 1407 DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV-----------TQVFIKVLDNND 1455
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
+ P F + Y +SED T +L+++ATD+D + I I K F ++
Sbjct: 1456 NGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK--FRIDP 1513
Query: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
TG++ TA + + ++ D A V+V+V + D +N
Sbjct: 1514 STGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
Score = 302 bits (773), Expect = 2e-81
Identities = 311/1100 (28%), Positives = 490/1100 (44%), Gaps = 97/1100 (8%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
Query: 192 QYNPDDPDRAQNLNERRTTTT-------------TLTVDVLDGDDLGPMFLPCVLVPNTR 238
N DR + + TT ++ V LDG V+V +
Sbjct: 2536 -INDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDEN 2594
Query: 239 DCRP----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 294
D P + Y+A++ ++ + +QAID D I YS+
Sbjct: 2595 DNAPQFMTVEYRASVRA-----DVGRGHLVTQVQAIDPDDGANSR-----ITYSLYSEAS 2644
Query: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP-AFAGLHIEILDENN 353
+ P + N+ + +KA D G P+ + ++I +L
Sbjct: 2645 VSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV-DGGIPVKHSLIPVYIHVLPPET 2703
Query: 354 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS 413
P FT Y I E +G+T+ D+L + + + E PE N+
Sbjct: 2704 FLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWFSTVNGER---PE-----NNKGG 2754
Query: 414 VFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTP 470
+F + Q T + L + +DRE + F + A D V V V+I+V+D NDN P
Sbjct: 2755 IFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKP 2812
Query: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-----FIINKTT 525
F SYD + M G + Q+ A+D D G+NG++TY + +Q + F I+ T
Sbjct: 2813 VFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNT 2872
Query: 526 GLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 585
G I+ ++ T+ +V A+D A +S V + V N+ +P F Q +Y
Sbjct: 2873 GWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTALVSVRVTDINDNAPV-FAQEVYR 2930
Query: 586 LEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQRVFNLS--ETTGILTLGKAL 639
+ E+ G V+ L DR+ + +Y I G+P+ F L ++ + + + L
Sbjct: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPL 2990
Query: 640 DRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 699
DRE D Y L ITA+DG + A V + V+DVNDN+PV D L + +N +
Sbjct: 2991 DREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
Query: 700 GQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIYTAVKLNREVRDYYELVVVATDG 757
+V A D D G NG + YSL N F +G + T L+RE Y L+ ATDG
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG 3108
Query: 758 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--V 815
S + L ++ D++DN PVF++ Y V EN + +++A D D+G N V
Sbjct: 3109 GGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKV 3166
Query: 816 SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY-GTMPPGIAT 874
Y + + F++ +G + L + LD E Q++S V A D G + T
Sbjct: 3167 VYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQSSYNISVRATDQSPGQSLSSLTT 3221
Query: 875 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
VT+ V D+ND PPVF +R Y V D GT + V+A D R + Q
Sbjct: 3222 VTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQ 3281
Query: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 994
F++ +G + L+ E F LVV A D G P +S+ ATV I + +
Sbjct: 3282 -----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVND 3336
Query: 995 IP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNIT 1049
P +F+Q+ Y +SE A G V ++ A + N I +SIV+G+ ++ F ++ +
Sbjct: 3337 NPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVL 3395
Query: 1050 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1109
G++ V LD E + Y L VQA + +P+ S+TA V I+I D N++ PVF
Sbjct: 3396 GLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAMSSTATVNIDISDVNDNSPVFTP 3448
Query: 1110 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1169
Y + E+ + TS+L++ TD+D+ + I+ +E E FV++ + G++++
Sbjct: 3449 ANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH-GILRS 3505
Query: 1170 AMLFHNMRRSYFKFQVIATD 1189
A++F + + V A D
Sbjct: 3506 AVVFQHTESLEYVLCVQAKD 3525
Score = 295 bits (755), Expect = 3e-79
Identities = 322/1163 (27%), Positives = 526/1163 (45%), Gaps = 134/1163 (11%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV---- 190
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
Query: 191 -----------IQYNPDDPDRAQNLNERRTTTTTLTVDVLD----GDDLGPMFLPCVLVP 235
I Y D DR N +L ++ D G L + V +
Sbjct: 874 TQQFAINSSTGIVYVADQLDRESKAN------YSLKIEARDKAESGQQLFSVVTLKVFLD 927
Query: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 295
+ DC P ++ ++ E+L V ++ D D + + YS++
Sbjct: 928 DVNDCSPAFIPSSY-SVKVLEDLPVGTVIAWLETHDPDLGLGGQ-----VRYSLV----N 977
Query: 296 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD--E 351
DY F + + + L + ++ + Q ++L ++A +D G P L + + + +E++D E
Sbjct: 978 DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRA-KDKGRPVSLSSVSFVEVEVVDVNE 1036
Query: 352 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 411
N +PYF + G + E++ +G TS L++ A D+D +D E+ + D
Sbjct: 1037 NLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARDED--SGRDGEIQYSIRDG 1085
Query: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNT 469
+ + + + +T +DRE +Y ++ A D V + V I+V D NDN
Sbjct: 1086 SGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Query: 470 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI 528
P E Y V + SVIQ+ A D D SN ++TY I G Q F IN TGLI
Sbjct: 1146 PLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLI 1205
Query: 529 -TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 587
T + ++ + L V D P + S V ++VL N + P+FP+ +Y ++
Sbjct: 1206 TTTSRKLDREQQAEHFLEVTVTDGGP--SPKQSTIWVVVQVL-DENDNKPQFPEKVYQIK 1262
Query: 588 ISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 642
+ E R G + A DR+ I+Y+I +G+ F + TG+++ K
Sbjct: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAG 1322
Query: 643 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---FD-PYLPRNLSVVEEEANA 697
S D IL I A D GRP +STA ++I +P+ FD P+ N +V+E +
Sbjct: 1323 SYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY--NFTVMESDRVT 1378
Query: 698 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVA 754
+ V + P N + + + GNF++ F G+I A L+ E R Y + V
Sbjct: 1379 EIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEV 1435
Query: 755 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 814
TDG + + IKVLD +DN P F+ Y V + E++ T ILQIEA D D
Sbjct: 1436 TDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHK 1492
Query: 815 VSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 871
+SY + S F + P TG L LD+EA +I + F
Sbjct: 1493 LSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF----PYRRN 1548
Query: 872 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 931
+A V V V+D ND+ P F+ +Y+ V A G+ + V A D D G A +
Sbjct: 1549 LARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD-KGENAELIY---- 1603
Query: 932 DVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVVVAFDDGEPVMSSSATVKI 987
++ ++F++E V+ + + +EP TT+ F L + D G P MS++A V+I
Sbjct: 1604 TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
Query: 988 LV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGIN 1046
V + P+F ++Y+ V+E GT V +ISA + +++Y + G+ F IN
Sbjct: 1660 SVTMSDNSHPKFIHKDYQ-AEVNENVDIGTSVILISAIS-QSTLIYEVKDGDINGIFTIN 1717
Query: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
+GVI LDYE +SY L +QA ++ + +N A V I+I DEN++ PV
Sbjct: 1718 PYSGVITTQKALDYERTSSYQLIIQATNMAGMASN---------ATVNIQIVDENDNAPV 1768
Query: 1107 FQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV 1159
F Y G +SE A + S L ++ATD D+ +++ Y+++ K+ F
Sbjct: 1769 FLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV---ESTAKKFFT 1825
Query: 1160 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVP 1219
V++ TG I+T + ++F F V D L+ ++ V +++++V N
Sbjct: 1826 VDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV------EVNIEVTDVNDN 1879
Query: 1220 PTLVEKKIEDLTEILDRYVQEQI 1242
P + + + + +L YV ++
Sbjct: 1880 PPVFTQAVFETILLLPTYVGVEV 1902
Score = 278 bits (712), Expect = 3e-74
Identities = 313/1165 (26%), Positives = 494/1165 (42%), Gaps = 127/1165 (10%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQV--QCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
+ +TG DR+ ++ +VV+ + + +V ++ VR+ + D NDNSP F YY
Sbjct: 2035 IQTTGVPFDREE-QELYELVVEASRELDHLRVARVV---VRVNIEDINDNSPVFVGLPYY 2090
Query: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPDRAQNLNE 206
A V GT I+ A D D GPNG++ YV+Q NP+ + N+
Sbjct: 2091 AAVQVDAEPGTLIY-----QVTAIDKDKGPNGEVTYVLQDDYGHFEINPN----SGNVIL 2141
Query: 207 RRTTTTTLT-----VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP----EE 257
+ + L+ V +L D P V +P T A+P P
Sbjct: 2142 KEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPIT------IVNKAMPVFDKPFYTASV 2195
Query: 258 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 317
I + PI +I N P + GI+Y I+ G P + F++ T L ++ P++
Sbjct: 2196 NEDIRMNTPILSI----NATSPEGQ-GIIYIIIDGDPF---KQFNIDFDTGVLKVVSPLD 2247
Query: 318 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL------DENNQSPYFTMPSYQGYILESA 371
+ + L I+A A G E+ D N+ P F P+Y + E++
Sbjct: 2248 YEVTSAYKLTIRASD-------ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEAS 2300
Query: 372 PVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
+G T L++V++D D E+ K + + Y S + + +
Sbjct: 2301 LIG---------TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARM 2351
Query: 432 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 489
+D E Q T + + D S V+V+I + D NDN P F ++ Y+ YV G
Sbjct: 2352 LDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGH 2411
Query: 490 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
V + A DAD + Y IL G + F+++ +G+IT++ + + Y+L V
Sbjct: 2412 FVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV 2471
Query: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG 608
+D S V+I VL N S P F Q Y E+ E + G +++++ATD +
Sbjct: 2472 SDGL-----FTSTAQVHIRVLGANLYS-PAFSQSTYVAEVRENVAAGTKVIHVRATDGDP 2525
Query: 609 DS---ITYAIENGDPQRVFNLSETTGILTLGKALDRES--TDRYILIITASDGRPDGTST 663
+ I+YAI N + F L ++ G + + LDRE+ + + A DG T+
Sbjct: 2526 GTYGQISYAIINDFAKDRF-LIDSNGQVITTERLDRENPLEGDVSIFVRALDG-GGRTTF 2583
Query: 664 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL---- 719
TV ++V D NDNAP F R + V QV+A DPD G N ++ YSL
Sbjct: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEA 2643
Query: 720 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
+ +L I NG + T N+ V A DG + +HS + + I VL +
Sbjct: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703
Query: 778 NSPVFTNSTYTVLVEENLPAGTTI--LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTG 835
P FT S Y+ + E+ G+T+ L+I + V+ F + TG
Sbjct: 2704 FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETG 2763
Query: 836 ELSLLRSLDYEAFP--DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRI 893
+ L + LD E P + + T ++ DI T+ V + V D+ND PVF
Sbjct: 2764 TIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTV-----DVDIKVLDLNDNKPVFETSS 2818
Query: 894 YKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVEEDSGRVI 952
Y ++ GT +T V A D D +V Y + D Q F ++ ++G +
Sbjct: 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGA--NGQVTYSLHSDSQPEKVMEAFNIDSNTGWIS 2876
Query: 953 TRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSE 1010
T +L+ E F VVA D GE +SS+A V + V + P F QE YR V E
Sbjct: 2877 TLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYR-GNVKE 2935
Query: 1011 LATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFGINNITG--VIYVNGPLDYETR 1063
G +V V+S + +N+ + Y I GN F + + +YV PLD E +
Sbjct: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQ 2995
Query: 1064 TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1122
Y L + A D L V A V + + D N++ PV + Y + ED
Sbjct: 2996 DIYFLNITATDGLFV-----------TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
Query: 1123 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1182
+L+V A D D G+ + Y L G F ++ +G +KT L R +
Sbjct: 3045 NKIILKVSAKDADIGSNGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
Query: 1183 FQVIATDDYGKGLSGKADVLVSVVN 1207
ATD G+ +++ VN
Sbjct: 3101 LMAKATDGGGRFCQSNIHLILEDVN 3125
Score = 271 bits (693), Expect = 4e-72
Identities = 310/1129 (27%), Positives = 481/1129 (42%), Gaps = 116/1129 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
V ++V D NDN P F +Y T++E + +GT + S D D N + Y I
Sbjct: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHYQIV 2327
Query: 192 --QYNPDDPDR----------AQNLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNT 237
YN D A+ L+ TL V +D L L + + +
Sbjct: 2328 QDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDV 2387
Query: 238 RDCRP----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 293
D P L Y++ + EL +QA D D SD + YSIL G
Sbjct: 2388 NDNPPVFNQLIYESYVSELAPRGHF-----VTCVQASDAD-----SSDFDRLEYSILSGN 2437
Query: 294 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
F M ++ ++L + + L + + A +HI +L N
Sbjct: 2438 DR---TSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANL 2491
Query: 354 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT- 412
SP F+ +Y + E+ G T + + A D D T + +ND+
Sbjct: 2492 YSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD-PGTYGQISYAIINDFAK 2541
Query: 413 SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 470
F + G + + +DRE + + + A DG + V + V+D NDN P
Sbjct: 2542 DRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAP 2598
Query: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ---GDFI-INKTTG 526
F + Y V D+ G V Q+ A+D D+G+N ITY + A D + I+ G
Sbjct: 2599 QFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNG 2658
Query: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
+ + + V+A D P ++S+ VYI VLPP P F Q YS
Sbjct: 2659 WMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHVLPPET-FLPSFTQSQYSF 2715
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----VFNLSETTGILTLGKALDR 641
I+E +G+ + L+ + ++ ++ NG+ P+ +F + + TG + L K LDR
Sbjct: 2716 TIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDR 2773
Query: 642 ESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 699
E++ + + A+ + D T V+I V D+NDN PVF+ + + +
Sbjct: 2774 ETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKL 2833
Query: 700 GQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSIYTAVKLNREVRDYYELVV 752
QV+A D D G NGQV YSL + + F I SN G I T L+ E + V
Sbjct: 2834 TQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSV 2893
Query: 753 VATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD--- 808
VA+D G ST ++++V DI+DN+PVF Y V+E+ P G + + D
Sbjct: 2894 VASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDT 2953
Query: 809 VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFL-VEAFD-I 864
D+ VSY I + FAL E + + R LD E E I FL + A D +
Sbjct: 2954 SDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-----EQDIYFLNITATDGL 3008
Query: 865 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924
+ T A V V V D+ND PV + Y ++ D I V A+DAD
Sbjct: 3009 FVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGS--NG 3062
Query: 925 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 984
+RY + + S F ++ +SG + T L+ E ++ L+ A D G S+
Sbjct: 3063 YIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIH 3118
Query: 985 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEED 1041
+ IL P F+ + Y ATK + V + IN+ +VYS+ + +
Sbjct: 3119 L-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGG 3176
Query: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
F I++ +G+I + PLD E ++SY + V+A S S+ V I + D N
Sbjct: 3177 VFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSPGQSLSSLTTVTITVLDIN 3230
Query: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
++PPVF+++ Y+ V ED T VL V AT KD G + + Y LI ++GK F +
Sbjct: 3231 DNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY-LIRSGNEQGK--FKIN 3287
Query: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
TG I + + F V A D LS A V +++ + D
Sbjct: 3288 PKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVND 3336
Score = 266 bits (681), Expect = 1e-70
Identities = 307/1141 (26%), Positives = 494/1141 (43%), Gaps = 120/1141 (10%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
Query: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
+V D NDN+P F Y A+V G + A D DDG N +I Y +
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSLYSEA 2643
Query: 196 D---------DPDRA-----QNLNERRTTTTTLTVDVLDG-----DDLGPMFLPCVLVPN 236
DPD N N+ + T + V +DG L P+++ VL P
Sbjct: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIH-VLPPE 2702
Query: 237 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVG-TPE 295
T +P + I I + I P + + +S + G PE
Sbjct: 2703 T----------FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQN---VWFSTVNGERPE 2749
Query: 296 DYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 350
+ F + T + L + ++R+ FH K I ++ + + + I++LD
Sbjct: 2750 NNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVD---IVFTVDVDIKVLD 2806
Query: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
N+ P F SY I+E PVG ++ +R + +D LH
Sbjct: 2807 LNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------VRAIDMDWGANGQVTYSLHSDSQP 2859
Query: 411 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAND 467
+ T +++ L+ +D E T+TFS+ A D S +V+++V D ND
Sbjct: 2860 EKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDIND 2919
Query: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS-NGEITYEILVG-AQGDFIIN--K 523
N P F + Y V PG+ V L+ D D N +++Y I G +G F + +
Sbjct: 2920 NAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ 2979
Query: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
+ + + ++ Y L + A D + V + V N+ SP Q+
Sbjct: 2980 SEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ-----AMVEVSVSDVNDNSPV-CDQVA 3033
Query: 584 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALD 640
Y+ + E + ++L + A D + S I Y++ G F L +G L LD
Sbjct: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLD 3092
Query: 641 RESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEA-NA 697
RE Y L+ A+DG + +++++ DVNDN PVF D Y N V E A A
Sbjct: 3093 RERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNPPVFSSDHY---NTCVYENTATKA 3148
Query: 698 FVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 755
+ +V+A DPD GIN +V YSL + +F I +S+G I L+RE + Y + V AT
Sbjct: 3149 LLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRAT 3208
Query: 756 DGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 814
D + S+L T+ I VLDI+DN PVF Y V V E+ GT +L + A D+G N
Sbjct: 3209 DQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTN 3268
Query: 815 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 872
++Y IRS + F ++P TG +S+ LDYE +VEA D +
Sbjct: 3269 AEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC----KRFYLVVEAKDGGTPALSAV 3324
Query: 873 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 932
ATV + + D+ND PP FS+ +Y +++ DA+ G + + AED D P ++ + + +
Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVD--SQPNGQIHFSIVN 3382
Query: 933 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
+ F V+ G V + L+ E + + L+V A D G P MSS+ATV I +
Sbjct: 3383 GD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439
Query: 993 GE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ-----SIVYSIVSGNEEDTFGIN 1046
+ P FT Y + E GT + + + +SI+SGNEE+ F +
Sbjct: 3440 NDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEF-VL 3497
Query: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
+ G++ + YVL VQA + P + + + + + +E+ H P
Sbjct: 3498 DPHGILRSAVVFQHTESLEYVLCVQA-------KDSGKPQQVSHTYIRVRVIEESTHKPT 3550
Query: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
ED + ++ ATD+D Y V+ + L E K F V ++ G
Sbjct: 3551 AIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLTFAL----KSEQKSLFKVNSHDGK 3604
Query: 1167 I 1167
I
Sbjct: 3605 I 3605
Score = 262 bits (670), Expect = 2e-69
Identities = 275/1040 (26%), Positives = 465/1040 (44%), Gaps = 106/1040 (10%)
Query: 212 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 271
T + + VLD +D GP F PN Y I E ++ P I+A D
Sbjct: 1444 TQVFIKVLDNNDNGPEFSQ----PN--------YDVTISE-----DVLPDTEILQIEATD 1486
Query: 272 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 331
+D ++ + Y++ R F + P T L E ++ + K L I
Sbjct: 1487 RD-------EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
Query: 332 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 391
A + + + D N+ SPYFT P Y+ + ESA +G+ + L++ A
Sbjct: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAV---------LQVTA 1590
Query: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 451
LDKD + + + + ++F + + +T+ + D + SI D Q
Sbjct: 1591 LDKDKGENAELIYTIEAGNTGNMFKIEP--VLGIITICKEPDMTTMGQFVLSIKVTD--Q 1646
Query: 452 ESEPV----IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 507
S P+ IV I V ++++ P F Y V ++ G SVI ++A+ S +
Sbjct: 1647 GSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI-----SQSTL 1701
Query: 508 TYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 566
YE+ G G F IN +G+IT ++ +Y L +QA + A A S TV I
Sbjct: 1702 IYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMA----SNATVNI 1757
Query: 567 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL-------LNLQATDREGDS---ITYAIE 616
+++ N+ +P F YS +SEA + +++ L ++ATD + + + Y I
Sbjct: 1758 QIVDENDNAPV-FLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV 1816
Query: 617 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT--STATVNIVVTDV 673
++ F + +TG + LD E+ + + D G P T S VNI VTDV
Sbjct: 1817 ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDV 1876
Query: 674 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN 731
NDN PVF + + ++ V +V ATDPD+ + ++ YSL G+ ++ F I SN
Sbjct: 1877 NDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSN 1935
Query: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
+ T +K N +D+Y L+V +DG +ST + I V + D+ FT S Y+ +
Sbjct: 1936 SGVLT-IKNNNLSKDHYMLIVKVSDGKF---YSTSMVTIMVKEAMDSGLHFTQSFYSTSI 1991
Query: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
EN T + + A L + Y I +P K F + +G ++++ ++
Sbjct: 1992 SENNTNITKVAIVNAVGNRLNEPLKYSILNPGNK--FKIKSTSG---VIQTTGVPFDREE 2046
Query: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 911
+ +VEA + V V ++D+ND PVF Y V DA GT I V
Sbjct: 2047 QELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQV 2106
Query: 912 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI-FKLVVV 970
A D D P V Y + D FE+ +SG VI + N + + I + + ++
Sbjct: 2107 TAIDKDKG--PNGEVTYVLQD-----DYGHFEINPNSGNVILKEAFNSDLSNIEYGVTIL 2159
Query: 971 AFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1030
A D G+P +S+S + I +++ +P F + Y ++ ++ + + + Q I
Sbjct: 2160 AKDGGKPSLSTSVELPITIVNKA-MPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGI 2218
Query: 1031 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1089
+Y I+ G+ F I+ TGV+ V PLDYE ++Y L ++A D+L A + V
Sbjct: 2219 IYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVD---- 2274
Query: 1090 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1149
+ + D N++PP+F + Y +SE + + T VL+V + D D+ N ++ Y+ I+
Sbjct: 2275 -----LLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQ-IVQ 2328
Query: 1150 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV------ 1203
+ F +++ +GLI TA + + + +V + D LS + V +
Sbjct: 2329 DTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVN 2388
Query: 1204 ---SVVNQLDMQVIVSNVPP 1220
V NQL + VS + P
Sbjct: 2389 DNPPVFNQLIYESYVSELAP 2408
Score = 251 bits (640), Expect = 6e-66
Identities = 306/1242 (24%), Positives = 516/1242 (41%), Gaps = 108/1242 (8%)
Query: 37 GGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFL 96
G P +V+ID +S N +V +++ T ++ DY+ + +L
Sbjct: 2303 GTPVLQVVSIDADSENNK-MVHYQIVQDTY------------NSTDYFHIDSSSGLIL-- 2347
Query: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE-VRIVVRDRNDNSPTFKHESYYAT 155
T R+LD + + ++V+ I+ ++ V I + D NDN P F Y +
Sbjct: 2348 --TARMLDHEL---VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDD------GPNGQIEYVIQYNPDDPDRAQNLNERRT 209
V+EL P G + + D ++D D N + +++ + + +R
Sbjct: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRME 2462
Query: 210 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 269
+L V V DG +F V + R Y A + E V + A
Sbjct: 2463 PLYSLNVSVSDG-----LFTSTAQV-HIRVLGANLYSPAFSQSTYVAE-----VRENVAA 2511
Query: 270 IDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 329
+ +++ PG I D+ + + ++ E ++R+ + D+ I
Sbjct: 2512 GTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIF 2571
Query: 330 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 389
+G F + + ++DEN+ +P F Y+ + G ++ ++
Sbjct: 2572 VRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVT---------QV 2622
Query: 390 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI---TRYLTLLQPVDREEQQTYTFSITA 446
A+D D D + + L SV I ++ ++ + +F + A
Sbjct: 2623 QAIDPD--DGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA 2680
Query: 447 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 504
DG + + V I V+ P+F + Y + D G +V L + +
Sbjct: 2681 VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWF 2740
Query: 505 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
+ E +G F+I + TG I + ++ + V A P ++ + + T
Sbjct: 2741 STVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAA---TIPLDKVDIVFT 2797
Query: 564 VYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAI-ENG 618
V +++ + N + P F Y I E M VG L ++A D + +TY++ +
Sbjct: 2798 VDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDS 2857
Query: 619 DPQRV---FNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDV 673
P++V FN+ TG ++ K LD E+ + + ASD G +STA V++ VTD+
Sbjct: 2858 QPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDI 2917
Query: 674 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD-AGINGQVHYSL--GNFNNLFR--- 727
NDNAPVF + R + V + D D + +N QV Y + GN F
Sbjct: 2918 NDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGL 2977
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ S +Y L+RE +D Y L + ATDG + + + V D++DNSPV Y
Sbjct: 2978 VQSEWKVYVKRPLDREEQDIYFLNITATDGLF---VTQAMVEVSVSDVNDNSPVCDQVAY 3034
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 845
T L+ E++P+ IL++ AKD D+G+N + Y + FF L P +GEL L LD
Sbjct: 3035 TALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDR 3093
Query: 846 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 905
E P + + +A D G + + +I++D+ND PPVFS Y V +
Sbjct: 3094 ERIP----VYSLMAKATDGGGRFCQ--SNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147
Query: 906 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 965
+T V A D D G+ V D +F ++ SG +I L+ E + +
Sbjct: 3148 ALLTRVQAVDPD-IGINRKVVYSLADSA-----GGVFSIDSSSGIIILEQPLDREQQSSY 3201
Query: 966 KLVVVAFDDGE-PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA 1024
+ V A D +SS TV I VL + P + V E + GT V + A
Sbjct: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFAT 3261
Query: 1025 A----INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
+ N I Y I SGNE+ F IN TG I V+ LDYE + L V+A
Sbjct: 3262 SKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEA-------K 3314
Query: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
+ P+ S A V I + D N++PP F + Y +SEDA + SV+ + A D D+
Sbjct: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNG 3374
Query: 1141 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1200
+ + ++ + F V+ GL+K R S + V A D +S A
Sbjct: 3375 QIHFSIV---NGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTAT 3431
Query: 1201 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDL-TEILDRYVQEQ 1241
V + + + D + + T V ++ + + T IL V ++
Sbjct: 3432 VNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDR 3473
Score = 247 bits (630), Expect = 9e-65
Identities = 313/1171 (26%), Positives = 493/1171 (42%), Gaps = 159/1171 (13%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
Query: 192 QYNPD-----------DPDRAQNLNER-RTTTTTLTVD----VLDGDDLGPMFLPCVLVP 235
+ D N +E+ R L VD + + + V +
Sbjct: 198 KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
Query: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 295
+ P + +E +VT + +D N + S SI+ G P
Sbjct: 258 RINEHAPTIHVVTHVPFSLEKEPTYAVVT--VDDLDDGANGEIES------VSIVAGDPL 309
Query: 296 DYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD 350
D E + E D F ++L ++A+ D G P A ++I
Sbjct: 310 DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAK-DKGSPQKCSALKAVYIGNPT 368
Query: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
+ F Y I E +P G +VA+ K + D E L +
Sbjct: 369 RDTVPIRFEKEVYDVSISEFSPPGV-------------VVAIVKLSPEPIDVEYKLSPGE 415
Query: 411 YTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 469
F + ++G+ + +P++ +++ Y +T +G +++ V I + DAND+T
Sbjct: 416 DAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTNKEGDLKAQ---VTISIEDANDHT 469
Query: 470 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 529
P F + YD YV + G SV+ ++A D D+G NG ITY I F+IN+ TG+I+
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVIS 529
Query: 530 IAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 588
++ Y V+A+D P R S V I + N+ S P F ++ I
Sbjct: 530 TTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVTIRIGNVNDNS-PLFEKVACQGVI 587
Query: 589 SEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRE--STD 645
S VG + + A D E + + Y I +G+ F L+ +G+L L K+L
Sbjct: 588 SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNG 647
Query: 646 RYILIITASDGRPDGTSTATVNIVVT---------------------------------- 671
+ L ITA+DG + ++NI V
Sbjct: 648 NFALRITATDGE-NLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706
Query: 672 ----------DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL- 719
+N P FD P +++V E+ A + ++KA D D+G NG+V +++
Sbjct: 707 NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766
Query: 720 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
GN ++ F I G + + ++RE D Y L + D + S L I V D +D
Sbjct: 767 DGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAND 826
Query: 778 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 835
NSPVF +Y+V + E+ GT I+Q+EA+D DLG+N V+Y + + + FA++ TG
Sbjct: 827 NSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTG 884
Query: 836 ELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRI 893
+ + LD E+ +A+ + +EA D G + T+ V + D+ND P F
Sbjct: 885 IVYVADQLDRES----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
Query: 894 YKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVI 952
Y V D GT I + E DP +VRY V+D FE+++ SG +
Sbjct: 941 YSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSLVNDYN-----GRFEIDKASGAIR 993
Query: 953 TRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRP 1005
L+ E + L V A D G PV +SS + V++ V LH P F
Sbjct: 994 LSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV----V 1049
Query: 1006 PPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1061
V E + GT V ++A + + I YSI G+ F I++ +GVI LD E
Sbjct: 1050 GSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRE 1109
Query: 1062 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1121
T SY L V A VV +T +VYIE++D N++ P+ + Y V E++
Sbjct: 1110 TMGSYWLTVYATDRGVV-------PLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSP 1162
Query: 1122 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRS 1179
SV++++A D D+ + + YR+ + F + TGLI T L +
Sbjct: 1163 KDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFFAINIKTGLITTTSRKLDREQQAE 1219
Query: 1180 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
+F +V TD G S K + VV LD
Sbjct: 1220 HF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
Score = 243 bits (621), Expect = 1e-63
Identities = 295/1168 (25%), Positives = 511/1168 (43%), Gaps = 119/1168 (10%)
Query: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
Query: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
Query: 187 IEY--VIQYNPD-DPDRA-------QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 236
+ Y V YN + D+A + L+ + LTV D + +
Sbjct: 971 VRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Query: 237 TRDCRPLTYQAAIPELRTPEEL--NPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGT 293
D + P+ + N I T +Q +D + S R G I YSI G+
Sbjct: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDED----SGRDGEIQYSIRDGS 1086
Query: 294 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
F + + ++ + ++R+ + L + A PL + ++IE+ D N+
Sbjct: 1087 GLGR---FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143
Query: 354 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS 413
+P + P Y ++E++P ++ ++I A D D + + + +
Sbjct: 1144 NAPLTSEPIYYPVVMENSPKDVSV---------IQIQAEDPDSSSNEKLTYRITSGNPQN 1194
Query: 414 VFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTP 470
F + +TG+ T + +DRE+Q + +T DG + + V +QV+D NDN P
Sbjct: 1195 FFAINIKTGLIT--TTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKP 1252
Query: 471 TFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGL 527
FPE Y + + R G+ + + A D DEG N EI+Y I+ G G F I+ TG+
Sbjct: 1253 QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGM 1312
Query: 528 ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL--PPNNQSPPRFPQLMYS 585
++ + G LT++A DN P +++S ++IE + PP + P F + Y+
Sbjct: 1313 VSSRK--QFTAGSYDILTIKAVDNGRP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYN 1368
Query: 586 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 645
+ E+ RV ++ + + + + I G+ F+ + G + + K LD E
Sbjct: 1369 FTVMESDRVTEIV-GVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRS 1427
Query: 646 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVK 703
Y + + +DG + V I V D NDN P F P + E+ + + Q++
Sbjct: 1428 IYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIE 1483
Query: 704 ATDPDAG--INGQVHYSLGNFN-NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAV 759
ATD D ++ VH S+ + + FRI S G +YTA +L+ E +D + L ++ D
Sbjct: 1484 ATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF 1543
Query: 760 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS--Y 817
R + + + V D +D+SP FTN Y V E+ G+ +LQ+ A D D G N Y
Sbjct: 1544 PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIY 1603
Query: 818 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--V 875
I + + F + P G +++ + PD F++ PP AT V
Sbjct: 1604 TIEAGNTGNMFKIEPVLGIITICKE------PDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657
Query: 876 TVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935
+ V ++ P F + Y+ V + GT + + A + S + Y V D
Sbjct: 1658 RISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDI 1710
Query: 936 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE- 994
IF + SG + T+ L+ E T+ ++L++ A + M+S+ATV I ++ +
Sbjct: 1711 ---NGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDN 1765
Query: 995 IPRFTQEEYRPPPVSELATKGTMVGVISAAAI-----------NQSIVYSIVSGNEEDTF 1043
P F +Y +SE A ++V + + + N +VY IV + F
Sbjct: 1766 APVFLFSQY-SGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFF 1824
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
+++ TG I LD+ET + V DS L + + +V IE+ D N+
Sbjct: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQL------TAESPVEVNIEVTDVND 1878
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVE 1161
+PPVF + + + + VL+V ATD D+ + Y L+ EG + F+++
Sbjct: 1879 NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLM-----EGSLDHFLID 1933
Query: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
+ +G++ + +N+ + ++ V +D
Sbjct: 1934 SNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
Score = 240 bits (613), Expect = 8e-63
Identities = 299/1241 (24%), Positives = 499/1241 (40%), Gaps = 199/1241 (16%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
Query: 193 YNPDDP--DRAQNLNERRTTT----------------TTLTVDVLDGDDLGPMFLPCVLV 234
NP + L+ RT++ T+ + ++D +D P+FL
Sbjct: 1716 INPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFL----- 1770
Query: 235 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 294
++ L+ A I + + +P++ I+A D D N ++Y I+ T
Sbjct: 1771 -FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSNRNAL-----LVYQIVESTA 1820
Query: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL--HIEILDEN 352
+ +FF + T + + ++ + F + L A + + +IE+ D N
Sbjct: 1821 K---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVN 1877
Query: 353 NQSPYFT---------MPSYQG--------------------YILESAPVGATISDSLNL 383
+ P FT +P+Y G Y L + + DS +
Sbjct: 1878 DNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSG 1937
Query: 384 TSPLRIVALDKD----------------------IEDTKDPELHLFLNDYTSVFTVTQTG 421
++ L KD +++ D LH + Y++ + T
Sbjct: 1938 VLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTN 1997
Query: 422 ITRYL----------------------------------TLLQPVDREEQQTYTFSITA- 446
IT+ T P DREEQ+ Y + A
Sbjct: 1998 ITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057
Query: 447 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 504
D ++ + V+V + + D NDN+P F + Y V D PG + Q+TA+D D+G N
Sbjct: 2058 RELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN 2116
Query: 505 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICT 563
GE+TY +L G F IN +G + + + Y +T+ A D P S+ T
Sbjct: 2117 GEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP-----SLST 2170
Query: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
+ N++ P F + Y+ ++E +R+ +L++ AT EG I Y I +GDP +
Sbjct: 2171 SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ 2230
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
FN+ TG+L + LD E T Y L I ASD + TV+++V DVNDN P+FD
Sbjct: 2231 FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQ- 2289
Query: 684 LPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI-TSNGSIYT 736
P + + E + V QV + D D+ N VHY + N + F I +S+G I T
Sbjct: 2290 -PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILT 2348
Query: 737 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 796
A L+ E+ + L V + D S + + I + D++DN PVF Y V E P
Sbjct: 2349 ARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAP 2408
Query: 797 AGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 854
G + ++A D D + Y I S + F + +G ++L P +
Sbjct: 2409 RGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLN 2468
Query: 855 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 914
++ F A V + V N Y P FS+ Y V + GT + V A
Sbjct: 2469 VSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRAT 2521
Query: 915 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAF 972
D DP ++ Y + + + F + + +G+VIT L+ E + V A
Sbjct: 2522 DGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTERLDRENPLEGDVSIFVRAL 2575
Query: 973 DDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AIN 1027
D G ++ TV+++V+ + P+F EYR +++ +G +V + A N
Sbjct: 2576 DGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG-RGHLVTQVQAIDPDDGAN 2632
Query: 1028 QSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1084
I YS+ S + D I+ G + G + T V+A + +
Sbjct: 2633 SRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA-------VDGGI 2685
Query: 1085 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1144
P K + VYI + P F + Y ++ED + ++V ++ +S
Sbjct: 2686 PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFST--- 2742
Query: 1145 RLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1202
+ E +G FV+E TG IK F F+V AT K D++
Sbjct: 2743 --VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPL-----DKVDIV 2795
Query: 1203 VSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1243
+V +D++V+ N + E T D + E +P
Sbjct: 2796 FTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
Score = 238 bits (608), Expect = 3e-62
Identities = 277/1081 (25%), Positives = 463/1081 (42%), Gaps = 119/1081 (11%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
Query: 192 QYNPD---------DPDR-----AQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 237
+ D DP A+ L+ L + V D + L V+V N
Sbjct: 1498 HSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIV-NV 1556
Query: 238 RDCR--------PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
D PL Y+A++ E L ++ + A+D+D+ + ++Y+I
Sbjct: 1557 EDANDHSPYFTNPL-YEASVFESAA---LGSAVLQ--VTALDKDKG-----ENAELIYTI 1605
Query: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 349
G + F + P +++ + + +F L IK P+ A A + I +
Sbjct: 1606 EAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT 1662
Query: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD--IEDTKDPELHLF 407
+N P F YQ + E+ +G TS + I A+ + I + KD
Sbjct: 1663 MSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQSTLIYEVKD------ 1707
Query: 408 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 467
D +FT+ + +T + +D E +Y I A + + VNIQ++D ND
Sbjct: 1708 -GDINGIFTINP--YSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDEND 1764
Query: 468 NTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGSNGEITYEILVG-AQGD 518
N P F Y + ++ P +S+++ + A DAD N + Y+I+ A+
Sbjct: 1765 NAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKF 1823
Query: 519 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
F ++ +TG I ++ + V D+ P S V IEV N+ +PP
Sbjct: 1824 FTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVND-NPPV 1882
Query: 579 FPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTL 635
F Q ++ + VG +L + ATD + + +TY++ G F + +G+LT+
Sbjct: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTI 1941
Query: 636 GKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
+ S D Y+LI+ SDG+ ST+ V I+V + D+ F S E
Sbjct: 1942 KN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSF---YSTSISEN 1994
Query: 696 NAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--TAVKLNREVRDYYELVV 752
N + +V + +N + YS+ N N F+I S + T V +RE ++ YELVV
Sbjct: 1995 NTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054
Query: 753 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 812
A+ H R + + + + + DI+DNSPVF Y V+ + GT I Q+ A D D G
Sbjct: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKG 2114
Query: 813 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 872
N + F ++P +G + L EAF ++I + V G P
Sbjct: 2115 PNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIEYGVTILAKDGGKPSLS 2169
Query: 873 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 932
+V + + +N PVF K Y V D TPI ++ A + G + Y + D
Sbjct: 2170 TSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQG-----IIYIIID 2224
Query: 933 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
P F ++ D+G + L+ E T+ +KL + A D + TV +LV
Sbjct: 2225 GD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDALTGARAEVTVDLLVNDV 2280
Query: 993 GEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVYSIVSG--NEEDTFGIN 1046
+ P + +SE + GT +V + + + N+ + Y IV N D F I+
Sbjct: 2281 NDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHID 2340
Query: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
+ +G+I LD+E VQ +L+V + PS S+ V+I I D N++PPV
Sbjct: 2341 SSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPV 2393
Query: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
F + Y VSE A V V+A+D D+ ++ + Y ++ + F++++ +G+
Sbjct: 2394 FNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL---SGNDRTSFLMDSKSGV 2450
Query: 1167 I 1167
I
Sbjct: 2451 I 2451
Score = 237 bits (604), Expect = 9e-62
Identities = 307/1224 (25%), Positives = 520/1224 (42%), Gaps = 145/1224 (11%)
Query: 41 ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTG 100
A + ++ E SR GT ++ + + G D I+ S++D + + +
Sbjct: 1047 AVVGSVKENSRIGTSVLQ-VTARDEDSGRDGEIQYSIRDGSGLGRFS--IDDESGVITAA 1103
Query: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESYYATVNEL 159
+LDR+ + S + V ++ V + EV I V D NDN+P YY V E
Sbjct: 1104 DILDRE---TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMEN 1160
Query: 160 TPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTT------ 213
+P ++ A D D N ++ Y I A N+ TTT+
Sbjct: 1161 SPKDVSVI-----QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE 1215
Query: 214 ------LTVDVLDGDDLGP-----MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 262
L V V DG GP V V + D +P + + +++ PE
Sbjct: 1216 QQAEHFLEVTVTDG---GPSPKQSTIWVVVQVLDENDNKP-QFPEKVYQIKLPERDRKKR 1271
Query: 263 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 322
P +A DR+ P ++ I YSI+ G D +FF + P+T +S +
Sbjct: 1272 GEPIYRAFAFDRDEGPNAE---ISYSIVDG--NDDGKFF-IDPKTGMVSSRKQFTAG--- 1322
Query: 323 KFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATIS 378
+D++ DNG P + A LHIE + + SP F P Y ++ES V
Sbjct: 1323 SYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV----- 1377
Query: 379 DSLNLTSPLRIVALDKDIEDTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 437
T + +V+ ++ P + ++ S F + T + + +P+D E++
Sbjct: 1378 -----TEIVGVVS----VQPANTPLWFDIVGGNFDSAFDAEKGVGT--IVIAKPLDAEQR 1426
Query: 438 QTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 497
Y S+ DG + + I+V+D NDN P F + +YDV + D+ P ++Q+ A
Sbjct: 1427 SIYNMSVEVTDGTNVAVTQVF-IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEAT 1485
Query: 498 DADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
D DE T + + F I+ +TG++ A ++ + L + D P
Sbjct: 1486 DRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFP- 1544
Query: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSIT 612
R ++ V + V N+ S P F +Y + E+ +G+ +L + A D+ E +
Sbjct: 1545 -YRRNLARVIVNVEDANDHS-PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELI 1602
Query: 613 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT 671
Y IE G+ +F + GI+T+ K D + +++L I +D G P ++TA V I VT
Sbjct: 1603 YTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT 1662
Query: 672 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-------GNFNN 724
+++ P F + ++ A V + + + S G+ N
Sbjct: 1663 MSDNSHPKF----------IHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDING 1712
Query: 725 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 783
+F I +G I T L+ E Y+L++ AT+ A S T+ I+++D +DN+PVF
Sbjct: 1713 IFTINPYSGVITTQKALDYERTSSYQLIIQATNMA--GMASNATVNIQIVDENDNAPVFL 1770
Query: 784 NSTYTVLVEENLPAGTTI-------LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 834
S Y+ + E P + + L I A D D N + Y+I K FF + T
Sbjct: 1771 FSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSST 1830
Query: 835 GELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKR 892
G + + +LD+E A F V D V + V D+ND PPVF++
Sbjct: 1831 GAIRTIANLDHETI----AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQA 1886
Query: 893 IYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 949
+++ ++ G + V A D D PP L S + +D F ++ +SG
Sbjct: 1887 VFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH---------FLIDSNSG 1937
Query: 950 -RVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV 1008
I NL+++ +++V DG+ +S T+ + + FTQ Y +
Sbjct: 1938 VLTIKNNNLSKD----HYMLIVKVSDGKFYSTSMVTIMVKEAMDSGL-HFTQSFY-STSI 1991
Query: 1009 SELATKGTMVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTS 1065
SE T T V +++A +N+ + YSI+ N + F I + +GVI G P D E +
Sbjct: 1992 SENNTNITKVAIVNAVGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQEL 2049
Query: 1066 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1125
Y L V+A L +LRV V + I+D N++ PVF Y V DA T
Sbjct: 2050 YELVVEASR---ELDHLRVA----RVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTL 2102
Query: 1126 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH-NMRRSYFKFQ 1184
+ +V A DKD G + Y L ++ F + +G + F+ ++ +
Sbjct: 2103 IYQVTAIDKDKGPNGEVTYVL-----QDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVT 2157
Query: 1185 VIATDDYGKGLSGKADVLVSVVNQ 1208
++A D LS ++ +++VN+
Sbjct: 2158 ILAKDGGKPSLSTSVELPITIVNK 2181
Score = 228 bits (580), Expect = 6e-59
Identities = 280/1096 (25%), Positives = 471/1096 (42%), Gaps = 138/1096 (12%)
Query: 163 GTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDR-AQNL------NERRTTTTTLT 215
G +FT G+ + D GQ++ ++ + + D N+ N ++++ LT
Sbjct: 759 GKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818
Query: 216 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 275
++V D +D P+F+ +Y I E + I T IQ +D++
Sbjct: 819 INVEDANDNSPVFIQD------------SYSVNILE-------SSGIGTEIIQVEARDKD 859
Query: 276 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQD 333
+ + + YS+L T + F ++ T + + + ++R+ + L I+A + +
Sbjct: 860 LGSNGE---VTYSVLTDTQQ-----FAINSSTGIVYVADQLDRESKANYSLKIEARDKAE 911
Query: 334 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
+G L + L + + D N+ SP F SY +LE PVG I+
Sbjct: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIA--------------- 956
Query: 394 KDIEDTKDPELHL-------FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 446
+T DP+L L +NDY F + + + + L + +D E+QQ Y ++ A
Sbjct: 957 --WLETHDPDLGLGGQVRYSLVNDYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRA 1012
Query: 447 FD---GVQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
D V S V ++V+D N+N TP FP+ + V + R G SV+Q+TA D D
Sbjct: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072
Query: 502 GSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 560
G +GEI Y I G+ G F I+ +G+IT A ++ +Y LTV A D S
Sbjct: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRG--VVPLYS 1130
Query: 561 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 617
VYIEV N+ +P + Y + + + + +V + +QA D + S +TY I +
Sbjct: 1131 TIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITS 1189
Query: 618 GDPQRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGRPD-GTSTATVNIVVTDVND 675
G+PQ F ++ TG++ T + LDRE + L +T +DG P ST V + V D ND
Sbjct: 1190 GNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDEND 1249
Query: 676 NAPVFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 730
N P F P + + E + + + A D D G N ++ YS+ GN + F I
Sbjct: 1250 NKPQF-PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDP 1308
Query: 731 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FT 783
+ ++ K Y L + A D + ST L I+ + SP+ F
Sbjct: 1309 KTGMVSSRK-QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY 1367
Query: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 843
N +TV+ + + ++ ++ + L + I F G + + + L
Sbjct: 1368 N--FTVMESDRVTEIVGVVSVQPANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPL 1421
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 901
D E Q + VE D GT +A V +K D ND P FS+ Y ++ D
Sbjct: 1422 DAE----QRSIYNMSVEVTD--GT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISED 1472
Query: 902 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 961
+ T I + A D D + V +D + F ++ +G + T L+ E
Sbjct: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEA 1528
Query: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1020
L ++ D P + A V + V + P FT Y V E A G+ V
Sbjct: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQ 1587
Query: 1021 ISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1076
++A N ++Y+I +GN + F I + G+I + D T +VL ++
Sbjct: 1588 VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIK----- 1642
Query: 1077 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1136
+ + P S TA V I + +N P F K Y V+E+ + TSV+ + A + T
Sbjct: 1643 --VTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST 1700
Query: 1137 GNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1194
+I +K+G F + Y+G+I T R S ++ + AT+ G
Sbjct: 1701 ----------LIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAG 1748
Query: 1195 LSGKADVLVSVVNQLD 1210
++ A V + +V++ D
Sbjct: 1749 MASNATVNIQIVDEND 1764
Score = 197 bits (502), Expect = 6e-50
Identities = 274/1148 (23%), Positives = 487/1148 (42%), Gaps = 173/1148 (15%)
Query: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPT 146
+D KQ F N T R D+ P+++ S+ + EV +V + N ++P
Sbjct: 998 LDYEKQQ-FYNLTVRAKDKGRPVSLSSVS--------------FVEVEVVDVNENLHTPY 1042
Query: 147 FKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNE 206
F + +V E + +GT++ A D D G +G+I+Y I+ D +
Sbjct: 1043 FPDFAVVGSVKENSRIGTSVL-----QVTARDEDSGRDGEIQYSIR----DGSGLGRFSI 1093
Query: 207 RRTTTTTLTVDVLDGDDLGPMFLPC-----------------VLVPNTRDCRPLT----Y 245
+ D+LD + +G +L + V + D PLT Y
Sbjct: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 246 QAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHP 305
+ E +P++++ I IQA D D S + Y I G P++ FF ++
Sbjct: 1154 YPVVME-NSPKDVSVI----QIQAEDPD-----SSSNEKLTYRITSGNPQN---FFAINI 1200
Query: 306 RTAELSLLEPVNR--DFHQKFDLVIKAEQDNGHPLPAFAGLH--IEILDENNQSPYFTMP 361
+T L+ +R D Q+ + ++ +G P P + + +++LDEN+ P F
Sbjct: 1201 KT---GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEK 1257
Query: 362 SYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTV 417
YQ + E D P+ R A D+D + + E+ + ND F
Sbjct: 1258 VYQIKLPE--------RDRKKRGEPIYRAFAFDRD--EGPNAEISYSIVDGNDDGKFFID 1307
Query: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPVIVNIQVMDANDNTPTF 472
+TG+ R++ ++ I V Q+S ++I+ + +P
Sbjct: 1308 PKTGMVS--------SRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIP 1359
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIA 531
Y +T M D V ++ V + + +N + ++I+ G F K G I IA
Sbjct: 1360 LTFDEPFYNFTVME-SDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIA 1418
Query: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
++ Y ++V+ D A + V+I+VL NN + P F Q Y + ISE
Sbjct: 1419 KPLDAEQRSIYNMSVEVTDGTNVA-----VTQVFIKVL-DNNDNGPEFSQPNYDVTISED 1472
Query: 592 MRVGAVLLNLQATDR-EGDSITYAIE---NGDPQRVFNLSETTGILTLGKALDRESTDRY 647
+ +L ++ATDR E ++Y + + R F + +TG+L + LD E+ D++
Sbjct: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKH 1532
Query: 648 ILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKAT 705
IL I D P + A V + V D ND++P F L SV E A + V QV A
Sbjct: 1533 ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTAL 1591
Query: 706 DPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPR 762
D D G N ++ Y++ GN N+F+I I T K + + L + TD P
Sbjct: 1592 DKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPM 1651
Query: 763 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 822
+T + I V D++ P F + Y V EN+ GT+++ I A + + Y ++
Sbjct: 1652 SATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS---QSTLIYEVKDG 1708
Query: 823 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 882
++ F ++P++G ++ ++LDYE + +S +++A ++ G ATV + + D
Sbjct: 1709 DINGIFTINPYSGVITTQKALDYE----RTSSYQLIIQATNMAGM--ASNATVNIQIVDE 1762
Query: 883 NDYPPVFSKRIYKGMVAPDA--------VKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
ND PVF Y G ++ A + +P+ + A DAD ++R V +
Sbjct: 1763 NDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPL-VIRATDAD-----SNRNALLVYQIV 1816
Query: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 994
F V+ +G + T NL+ E F V D G P +++ + V++ +
Sbjct: 1817 ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI----- 1871
Query: 995 IPRFTQEEYRPPPVSE-----LATKGTMVGV----ISA----AAINQSIVYSIVSGNEED 1041
T PP ++ + T VGV +SA + + + YS++ G+ D
Sbjct: 1872 --EVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LD 1928
Query: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
F I++ +GV+ + + ++ Y+L V+ + +T+ V I +++
Sbjct: 1929 HFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGKFY----------STSMVTIMVKEAM 1976
Query: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
+ F + FY +SE+ T V V A + Y ++ P K F ++
Sbjct: 1977 DSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLN--EPLKYSILNPGNK-----FKIK 2029
Query: 1162 TYTGLIKT 1169
+ +G+I+T
Sbjct: 2030 STSGVIQT 2037
Score = 186 bits (473), Expect = 1e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 316 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 375
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
Query: 376 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 435
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
Query: 436 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 486
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
Query: 487 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 538
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
Query: 539 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 598
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Query: 599 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 658
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
Query: 659 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 713
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
Query: 714 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 769
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 770 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 829
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
Query: 830 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 878
L+P +G L L +SL + + + A D P ++V+
Sbjct: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
Query: 879 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 906
+N P F K + V D G
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
Query: 967 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1025
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
Query: 1026 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1078
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
Query: 1079 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1138
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
Query: 1139 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1198
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
Query: 1199 ADVLVSVVNQLDMQVIVSN 1217
V +S V+ ++++V+ N
Sbjct: 1017 RPVSLSSVSFVEVEVVDVN 1035
Score = 174 bits (441), Expect = 7e-43
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 432 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 490
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 491 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 550
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
Query: 551 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
N + + +Y+ + N +P + + V ++
Sbjct: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 660
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
Query: 661 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
Query: 721 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
Query: 780 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 837
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
Query: 838 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 895
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
Query: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 947
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
Query: 948 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 989
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
Query: 990 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1029
L G + P F + V E G + I A + N
Sbjct: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
Query: 1030 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1089
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
Query: 1090 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1149
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
Query: 1150 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1209
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Query: 1210 DMQVIVSNVPPTLVEKKIEDL 1230
+ +P + K +EDL
Sbjct: 929 VNDCSPAFIPSSYSVKVLEDL 949
Score = 161 bits (407), Expect = 7e-39
Identities = 271/1110 (24%), Positives = 449/1110 (40%), Gaps = 171/1110 (15%)
Query: 212 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 271
T + + VLD +DL P+F P TY I E TP + VT A D
Sbjct: 142 TKVNIQVLDMNDLRPLF------------SPTTYSVTIAE-STPLRTSVAQVT----ATD 184
Query: 272 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI--- 328
D G Y + F +HP + +SL +N D ++DL I
Sbjct: 185 ADIGSN------GEFYYYFKNKVD----LFSVHPTSGVISLSGRLNYDEKNRYDLEILAV 234
Query: 329 ----KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
K +NG A +HIE ++E+ +P + ++ + LE P A
Sbjct: 235 DRGMKLYGNNGVSSTAKLYVHIERINEH--APTIHVVTHVPFSLEKEPTYA--------- 283
Query: 385 SPLRIVALDKDIEDTKDPELH---LFLNDYTSVFTVTQTGITRYLTLLQPVDREE----- 436
+V +D D++D + E+ + D F + + G ++L + +R++
Sbjct: 284 ----VVTVD-DLDDGANGEIESVSIVAGDPLDQFFLAKEG--KWLNEYKIKERKQIDWES 336
Query: 437 -QQTYTFSITAFD-GVQESEPVIVNIQVMD-ANDNTP-TFPEISYDVYVYTDMRPG--DS 490
Y ++ A D G + + + + + D P F + YDV + PG +
Sbjct: 337 FPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVA 396
Query: 491 VIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
+++L+ D + Y++ G F IN +GLI A + + Y L V
Sbjct: 397 IVKLSPEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK 450
Query: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR--- 606
+ A+ T+ IE N P F Q +Y ++E++ VG +L + A+D+
Sbjct: 451 EGDLKAQ-----VTISIE---DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKG 502
Query: 607 EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST-DRYILIITASD-GRP-DGTST 663
E ITY+I + + F +++ TG+++ + LD ES+ + Y I+ ASD G P S
Sbjct: 503 ENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESE 561
Query: 664 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN 723
V I + +VNDN+P+F+ + + + + V A D D + GN
Sbjct: 562 VNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNEL 621
Query: 724 NLFRITSNGSIYTAVK--LNREVRD-YYELVVVATDG------------AVHPRHSTLT- 767
F + + + K N +++ + L + ATDG +H + S+ +
Sbjct: 622 GFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
Query: 768 ----------LAIKVL-------------------DIDDNSPVFTNS-TYTVLVEENLPA 797
LA K+L I+ P F S V V+E+LP
Sbjct: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
Query: 798 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 855
G IL+I+A D D G N V + I F + TG+L +L +D E +I
Sbjct: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNI 801
Query: 856 TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 915
T +D+ +T+ V+D ND PVF + Y + + GT I V A D
Sbjct: 802 TI----YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
Query: 916 ADPPGLPASRVRYRV-DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 974
D V Y V D Q F + +G V L+ E + L + A D
Sbjct: 858 KDLGS--NGEVTYSVLTDTQ------QFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
Query: 975 GE--PVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA----AAIN 1027
E + S T+K+ + + P F Y + +L GT++ + +
Sbjct: 910 AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPV-GTVIAWLETHDPDLGLG 968
Query: 1028 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1087
+ YS+V+ + F I+ +G I ++ LDYE + Y L V+A R S
Sbjct: 969 GQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD------KGRPVSL 1021
Query: 1088 SNTAKVYIEIQD--ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1145
S+ + V +E+ D EN H P F +G V E++R+ TSVL+V A D+D+G + Y
Sbjct: 1022 SSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYS 1081
Query: 1146 LIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1205
+ G F ++ +G+I A + + V ATD L +V + V
Sbjct: 1082 I---RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEV 1138
Query: 1206 VNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1233
+ D + S P ++E +D++ I
Sbjct: 1139 EDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Score = 129 bits (323), Expect = 4e-29
Identities = 135/568 (23%), Positives = 248/568 (43%), Gaps = 87/568 (15%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
Query: 186 QIEY------------------VIQYNPDDPDRAQNLN-----------ERRTTTTTLTV 216
++ Y +I P D ++ + N + ++ TT+T+
Sbjct: 3165 KVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTI 3224
Query: 217 DVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 276
VLD +D P+F RD Y +PE +P T + ++I
Sbjct: 3225 TVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLAVFATSKDI 3265
Query: 277 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 336
++ I Y I G + F ++P+T +S+ E ++ + ++F LV++A+
Sbjct: 3266 GTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTP 3319
Query: 337 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 396
L A A ++I + D N+ P F+ Y I E A VG ++ I+ + +D+
Sbjct: 3320 ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV-----------ILLIAEDV 3368
Query: 397 EDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQE- 452
+ + ++H + D + FTV + + + + +DRE Y+ + A D G+
Sbjct: 3369 DSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAM 3426
Query: 453 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE-ITYEI 511
S VNI + D NDN+P F +Y + + G S++QL D D NG ++ I
Sbjct: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
Query: 512 LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
L G + + + G++ A + Y L VQA D+ P + ++ + + V+
Sbjct: 3487 LSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY--IRVRVIEE 3544
Query: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETT 630
+ P P ++ + + + G V+ + ATD++ D +T+A+++ + + +F ++
Sbjct: 3545 STHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKSLFKVNSHD 3602
Query: 631 G-ILTLGKALDRESTDRYILIITASDGR 657
G I+ LG LD + +Y+L ++ SDGR
Sbjct: 3603 GKIIALG-GLD---SGKYVLNVSVSDGR 3626
Score = 102 bits (253), Expect = 5e-21
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 521
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
Query: 522 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 577
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
Query: 578 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 633
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
Query: 634 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 687
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
Query: 688 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 743
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
Query: 744 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 796
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
Query: 797 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 856
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
Query: 857 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 914
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 915 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 973
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
Query: 974 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1030
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
Query: 1031 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1079
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 1080 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1113
+ +V SKS N +++ N P F K F
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 1114 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1170
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
Query: 1171 M 1171
M
Sbjct: 787 M 787
Score = 52.0 bits (123), Expect = 6e-06
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 1021 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1078
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
Query: 1079 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1138
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1139 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1193
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Query: 1194 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1232
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 303 bits (776), Expect = 1e-81
Identities = 320/1136 (28%), Positives = 505/1136 (44%), Gaps = 102/1136 (8%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
Query: 192 QYNPDDPDRAQNLNER----------RTTTTTLTVDV-LDGDDLGPMFLPC---VLVPNT 237
N DR +NER R T + V L D G C V++ +
Sbjct: 2532 -VNDFAKDRFY-INERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDD 2589
Query: 238 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
D P ++A E+ + A D D I Y+I + E
Sbjct: 2590 NDNAP-QFRATKYEVNIGSSAAKGTSVVKVLASDADEG-----SNADITYAIEADS-ESV 2642
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSP 356
++ + ++ E + ++ F ++A DNG P L +++IL Q P
Sbjct: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DNGSPSKESVVLVYVKILPPEMQLP 2701
Query: 357 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 416
F+ P Y + E P+G I S + +L K PE N S
Sbjct: 2702 KFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKG----NTPES----NRDESFVI 2753
Query: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI---VNIQVMDANDNTPTFP 473
Q+G L L + +D E + Y FSI A + E V V+IQV DANDN+P F
Sbjct: 2754 DRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFE 2810
Query: 474 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI----LVGAQGDFIINKTTGLIT 529
Y+ ++ ++ G VIQ+ A DAD G+NG++ Y + V F IN TG IT
Sbjct: 2811 SSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWIT 2870
Query: 530 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEI 588
++ Y + V A+D+ E+ T ++V + N SPPRF +Y +
Sbjct: 2871 TLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTV 2927
Query: 589 SEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQRVFNLS--ETTGILTLGKALDRE 642
SE G V+ L TD + + I TY I GDP F + + + + K LDRE
Sbjct: 2928 SEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDRE 2987
Query: 643 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 702
D Y+L ITA+DG +S A V + V D NDN+PV + L + + + Q+
Sbjct: 2988 KRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
Query: 703 KATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVH 760
ATD D N ++ Y+ LG+ F++ G + T+ L+RE + Y L+V ATDG
Sbjct: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG-- 3103
Query: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 818
R ++ + + D++DN+P F+ Y + V EN GT + +++A D D G N + Y
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYS 3163
Query: 819 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
+ F+++ +G + L + LD E +A T ++A D G AT TVI
Sbjct: 3164 L-IDSADGQFSINELSGIIQLEKPLDREL----QAVYTLSLKAVD-QGLPRRLTATGTVI 3217
Query: 879 VK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
V D+ND PPVF R Y V+ D + GT + VYA D + + Y +
Sbjct: 3218 VSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA--NAEITYSIISGN-- 3273
Query: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-I 995
F ++ +G V NL+ E + + L V A D G P +S ATV + V +
Sbjct: 3274 -EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNT 3332
Query: 996 PRFTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTFGINNITGVI 1052
P F+Q+ Y + + +++ V++ A N I YSI+ GN+ +F I+ + G +
Sbjct: 3333 PVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEV 3392
Query: 1053 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1112
V LD ET + Y L VQA ++ P + NT V I++ D N++ PVF + Y
Sbjct: 3393 KVTKLLDRETISGYTLTVQA-------SDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNY 3445
Query: 1113 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1172
+ E+ + SVL++ TD+D+ + + I+ E + F V G++ T+
Sbjct: 3446 SVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDE--KAFEVNP-QGVLLTSSA 3502
Query: 1173 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV-PPTLVEKKI 1227
+ ++ QV D +GK +S + +D++VI ++ PP ++ +I
Sbjct: 3503 IKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYIDIRVIEESIYPPAILPLEI 3550
Score = 296 bits (758), Expect = 1e-79
Identities = 319/1203 (26%), Positives = 525/1203 (43%), Gaps = 134/1203 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSIV 862
Query: 193 YNPDD---------PDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD---C 240
+ D + A+ L+ +L ++ D P V+V + +
Sbjct: 863 TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVND 922
Query: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
P T+ ++ E+L V ++A D D + YS+L +
Sbjct: 923 NPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL-----GQSGQVRYSLL----DHGEGN 973
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEI----LDENNQSP 356
F + + + +++ ++ + Q ++L ++A +D G P+ + ++E+ ++EN P
Sbjct: 974 FDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKGKPVSLSSTCYVEVEVVDVNENLHPP 1032
Query: 357 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 416
F+ +G + E APVG+ + + + A D+D +D E+ + D + V
Sbjct: 1033 VFSSFVEKGTVKEDAPVGSLV---------MTVSAHDEDAR--RDGEIRYSIRDGSGVGV 1081
Query: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 474
T + +DRE Y ++ A D V S + + I+V D NDN P E
Sbjct: 1082 FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSE 1141
Query: 475 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLI-TIAP 532
Y + + SV+Q+ A D D SN ++ Y+I G QG F I+ TGLI T +
Sbjct: 1142 PVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSR 1201
Query: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
++ + L V DN P +++I V +++L N + P+F Q Y + + E
Sbjct: 1202 KLDREQQDEHILEVTVTDNGSPP--KSTIARVIVKIL-DENDNKPQFLQKFYKIRLPERE 1258
Query: 593 RVG-------AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 642
+ L ++ ATD++ I+Y+IE+G+ F + TG+++ K
Sbjct: 1259 KPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS-SKRFSAA 1317
Query: 643 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR----NLSVVEEEANAF 698
+ I +GRP +ST ++I ++ P +P +V+E + A
Sbjct: 1318 GEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPKPSLEPISFEESFFTFTVMESDPVAH 1375
Query: 699 VGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDG 757
+ V + +P GI + GN+++ F + G+I A L+ E + Y L V ATDG
Sbjct: 1376 MIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG 1434
Query: 758 AVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS 816
+ LT + IKV+D +D+ P F+ S Y V++ E+ T ILQI A D D +
Sbjct: 1435 TT----TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLI 1490
Query: 817 YRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 873
Y + R P F L P TG L LD+EA + ++T +V D+ + A
Sbjct: 1491 YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV--HQHTLTVMVRDQDV--PVKRNFA 1546
Query: 874 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 933
+ V V D ND+ P F+ YKG V A G+ + V A D D + V Y ++
Sbjct: 1547 RIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKG--KNAEVLYSIESG 1604
Query: 934 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV-LHP 992
+ F ++ G + T L+ + L+V A D G P MS +V+I V +
Sbjct: 1605 NI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661
Query: 993 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1052
P+FT +EY +SE + G+ VG+++A + S+VY I GN D F IN +G I
Sbjct: 1662 NASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-QSSVVYEIKDGNTGDAFDINPHSGTI 1719
Query: 1053 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1112
LD+ET Y L +Q ++ S V + +QDEN++ PVF + Y
Sbjct: 1720 ITQKALDFETLPIYTLIIQGTNM---------AGLSTNTTVLVHLQDENDNAPVFMQAEY 1770
Query: 1113 IGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1165
G +SE A + + VL ++A D D + +++ Y ++ P + F +++ TG
Sbjct: 1771 TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV---HTYFAIDSSTG 1827
Query: 1166 LIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEK 1225
I T + S F F V D G + + + VI N P + K
Sbjct: 1828 AIHTVLSLDYEETSIFHFTVQVHD------MGTPRLFAEYAANVTVHVIDINDCPPVFAK 1881
Query: 1226 KIEDLTEILDRYVQEQIPGAKVV---------------VESIGARRHGDAFSLEDYTKCD 1270
+ + + +L Y G KV+ + SI G+ FS+ DY
Sbjct: 1882 PLYEASLLLPTY-----KGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM-DYKTGA 1935
Query: 1271 LTV 1273
LTV
Sbjct: 1936 LTV 1938
Score = 294 bits (752), Expect = 6e-79
Identities = 304/1140 (26%), Positives = 490/1140 (42%), Gaps = 108/1140 (9%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI-------QYNPDDPDRAQNLNERR 208
V T VG I A D D G NG++ Y + Q P + E
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELD 2144
Query: 209 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP----EELNPIIVT 264
T V V+ D P F V+VP T A+P P E I V
Sbjct: 2145 TLNKEYLVTVVAKDGGNPAFSAEVIVPIT------VMNKAMPVFEKPFYSAEIAESIQVH 2198
Query: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
P+ + + + + YSI G P F ++ T ++++ P++ + H +
Sbjct: 2199 SPVVHVQAN-----SPEGLKVFYSITDGDPFSQ---FTINFNTGVINVIAPLDFEAHPAY 2250
Query: 325 DLVIKAEQDNGHPLPAFAGLHIEIL------DENNQSPYFTMPSYQGYILESAPVGATIS 378
L I+A + G H E+ D N+ P F SY + E++ +G
Sbjct: 2251 KLSIRATD-------SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG---- 2299
Query: 379 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 438
TS +++ A D D E + +F N S T ++LL+ +D E+ +
Sbjct: 2300 -----TSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR 2354
Query: 439 TYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 496
+T + A DG S VIV + V D NDN P F + Y+ + G V + A
Sbjct: 2355 QHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKA 2414
Query: 497 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
DAD ++ Y IL G F+I+ TG+IT++ + Y+L + +D
Sbjct: 2415 YDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV--- 2471
Query: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS----- 610
S V++ V+ N S P F Q Y +E++E + +++ ++ TD GDS
Sbjct: 2472 --FRSSTQVHVTVIGGNLHS-PAFLQNEYEVELAENAPLHTLVMEVKTTD--GDSGIYGH 2526
Query: 611 ITYAIENGDPQRVFNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIV 669
+TY I N + F ++E I TL K LDRE+ ++ I + + + TVN++
Sbjct: 2527 VTYHIVNDFAKDRFYINERGQIFTLEK-LDRETPAEKVISVRLMAKDAGGKVAFCTVNVI 2585
Query: 670 VTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNN 724
+TD NDNAP F V +V A+D D G N + Y++ N
Sbjct: 2586 LTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKEN 2645
Query: 725 LFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 784
L +G I T L +++ V A D + S + + +K+L + P F+
Sbjct: 2646 LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSE 2705
Query: 785 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK--HFFALHPFTGELSLLRS 842
YT V E++P GT I I A+ + +PE F + +G L L +S
Sbjct: 2706 PFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS 2765
Query: 843 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 902
LD+E + SI L M + V++ VKD ND PVF Y+ + +
Sbjct: 2766 LDHETTKWYQFSI--LARCTQDDHEMVASV-DVSIQVKDANDNSPVFESSPYEAFIVENL 2822
Query: 903 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 962
G+ + + A DAD +V Y +D Q F + ++G + T L+ E
Sbjct: 2823 PGGSRVIQIRASDADSG--TNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKR 2880
Query: 963 TIFKLVVVAFDDGEPV-MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGV 1020
+++ VVA D GE + +SS+A V + V + PRFT E Y+ VSE +G ++ +
Sbjct: 2881 DNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYK-GTVSEDDPQGGVIAI 2939
Query: 1021 IS-----AAAINQSIVYSIVSGNEEDTFGINNITG--VIYVNGPLDYETRTSYVLRVQAD 1073
+S + IN+ + Y I G+ F + I +YV PLD E R +Y+L + A
Sbjct: 2940 LSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITAT 2999
Query: 1074 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1133
+ S+ A V +++ D N++ PV +K Y + ED ++++ ATD
Sbjct: 3000 D----------GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATD 3049
Query: 1134 KDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1193
D + + + Y L + G E F + TG +KT+ ++ + V ATD G+
Sbjct: 3050 ADIRSNAEITYTL----LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
Score = 284 bits (726), Expect = 7e-76
Identities = 274/1027 (26%), Positives = 455/1027 (44%), Gaps = 109/1027 (10%)
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFT 359
F + T L +L P++R+ K+ L I D G P A + LH+ ++D N+ P F
Sbjct: 765 FMIDMETGMLKILSPLDRETTDKYTLNITV-YDLGIPQKAAWRLLHVVVVDANDNPPEFL 823
Query: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419
SY + E V + I +++ A DKD+ P H+ + T T +
Sbjct: 824 QESYFVEVSEDKEVHSEI---------IQVEATDKDL----GPNGHVTYSIVTDTDTFSI 870
Query: 420 TGITRYLTLLQPVDREEQQTYTFSITAFDGVQES----EPVIVNIQVMDANDNTPTFPEI 475
+T + + +P+DRE Q ++ I A D +E V+V + + D NDN PTF
Sbjct: 871 DSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPP 930
Query: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 535
+Y V V D+ G ++ L A D D G +G++ Y +L +G+F ++K +G + I ++
Sbjct: 931 NYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD 990
Query: 536 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRV 594
+ Y LTV+A D P +S C V +EV+ N N PP F + + E V
Sbjct: 991 FEKKQVYNLTVRAKDKGKPVS-LSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV 1049
Query: 595 GAVLLNLQATD---REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 651
G++++ + A D R I Y+I +G VF + E TG++ LDREST Y L +
Sbjct: 1050 GSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTV 1109
Query: 652 TASD-GRPDGTSTATVNIVVTDVNDNA-----PVFDPYL----PRNLSVVEEEANAFVGQ 701
A+D G +S + I V DVNDNA PV+ P + P+++SVV Q
Sbjct: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV---------Q 1160
Query: 702 VKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYELVVVATDG 757
++A DPD+ N ++ Y + GN F I + T KL+RE +D + L V TD
Sbjct: 1161 IEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN 1220
Query: 758 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV-LVEENLP------AGTTILQIEAKDVD 810
P+ + + +K+LD +DN P F Y + L E P + + A D D
Sbjct: 1221 GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKD 1280
Query: 811 LGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 868
G N +SY I F + P TG +S R + A + + ++A D
Sbjct: 1281 EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYD---ILSIKAVD--NGR 1332
Query: 869 PPGIATVTVIVKDMNDYPPVFSKRIY-KGMVAPDAVKGTPIT-TVYAEDADPPGLPASRV 926
P +T + ++ ++ P + + ++ P+ + +PPG+P
Sbjct: 1333 PQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL--- 1389
Query: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
D+ S F+V++ +G +I L+ E + + L V A DG + + +K
Sbjct: 1390 ---WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-TDGTTTILTQVFIK 1445
Query: 987 ILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ----SIVYSIVSGNEE-- 1040
++ + P+F+ +Y + A + ++ +A++Q ++Y++ S +
Sbjct: 1446 VIDTNDHR-PQFSTSKYEVVIPEDTAPE---TEILQISAVDQDEKNKLIYTLQSSRDPLS 1501
Query: 1041 -DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1099
F ++ TG +Y + LD+E V +L V++ + VP K N A++ + + D
Sbjct: 1502 LKKFRLDPATGSLYTSEKLDHEA-------VHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
Query: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1157
N+H P F Y G V E A + + VL+V A DKD G + + Y I+ G G
Sbjct: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLY-----SIESGNIGNS 1609
Query: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
F+++ G IKTA ++ + V ATD +S V + V I N
Sbjct: 1610 FMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV-------TIADN 1662
Query: 1218 VPPTLVEK----KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTV 1273
P K ++ + I VV I GDAF + ++ +T
Sbjct: 1663 ASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQ 1722
Query: 1274 YAIDPQT 1280
A+D +T
Sbjct: 1723 KALDFET 1729
Score = 279 bits (714), Expect = 2e-74
Identities = 301/1136 (26%), Positives = 500/1136 (44%), Gaps = 135/1136 (11%)
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLD--------GDDLGPM 227
A D D+G NG + Y I P + +T+ L +++ D G
Sbjct: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
Query: 228 F------LPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSD 281
+ L + + N D PL ++ E P +L + AID D +
Sbjct: 547 YRREVEVLATITLNNLNDNTPL-FEKINCEGTIPRDLGVGEQITTVSAIDAD-------E 598
Query: 282 RPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK---FDLVIKAEQDNGHPL 338
+ Y I G D FF ++P + LSL + K L I A
Sbjct: 599 LQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
Query: 339 PAFAGLHI----------------------EILDENN-------QSPYFTMPSYQGYILE 369
P + + + ++L N + +F S +I +
Sbjct: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
Query: 370 ---SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGIT 423
+ P G + ++ + S + I D++ + +L + N+ + +TG+
Sbjct: 716 FRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGM- 773
Query: 424 RYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPVIVNIQVMDANDNTPTFPEISYDVYV 481
L +L P+DRE YT +IT +D G+ Q++ ++++ V+DANDN P F + SY V V
Sbjct: 774 --LKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEV 831
Query: 482 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 541
D +IQ+ A D D G NG +TY I+ F I+ TG++ IA ++ +
Sbjct: 832 SEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD-TFSIDSVTGVVNIARPLDRELQHE 890
Query: 542 YALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 600
++L ++A D A E TV ++V L N +PP F Y +++ E + G V++
Sbjct: 891 HSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW 948
Query: 601 LQATD---REGDSITYA-IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD- 655
L+A D + + Y+ +++G+ F++ + +G + + + LD E Y L + A D
Sbjct: 949 LEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDK 1006
Query: 656 GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
G+P +ST V + V DVN+N PVF ++ + + + V V A D DA +
Sbjct: 1007 GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRD 1066
Query: 713 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 769
G++ YS+ G+ +F+I G I T+ +L+RE +Y L V ATD V P S + +
Sbjct: 1067 GEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126
Query: 770 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 827
I+V D++DN+P + Y + EN P +++QIEA D D +N + Y+I S + F
Sbjct: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGF 1186
Query: 828 FALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDY 885
F++HP TG ++ R LD E + +T G+ P IA V V + D ND
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN-----GSPPKSTIARVIVKILDENDN 1241
Query: 886 PPVFSKRIYKGMV----APDAVKGT---PITTVYAEDADPPGLPASRVRYRVDDVQFPYP 938
P F ++ YK + PD + P+ V A D D P + + Y ++D
Sbjct: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEG--PNAEISYSIEDGN---E 1296
Query: 939 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---HPGEI 995
F +E +G V ++ I L + A D+G P SS+ + I + P
Sbjct: 1297 HGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLE 1354
Query: 996 PRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1055
P +E + V E M+GVIS + + I GN + F ++ TG I V
Sbjct: 1355 PISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVA 1414
Query: 1056 GPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1114
PLD E +++Y L V+A D +L +V+I++ D N+H P F Y
Sbjct: 1415 KPLDAEQKSNYNLTVEATDGTTTIL-----------TQVFIKVIDTNDHRPQFSTSKYEV 1463
Query: 1115 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1170
+ ED T +L++ A D+D N + + P+ K F ++ TG + T+
Sbjct: 1464 VIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKK--FRLDPATGSLYTS 1517
Score = 258 bits (658), Expect = 5e-68
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
Query: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
Query: 421 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 476
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
Query: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 535
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
Query: 536 MIVGRT---YALTVQAADN---------------------------------------AP 553
+G ++L + A D A
Sbjct: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
Query: 554 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 610
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
Query: 611 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 669
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
Query: 670 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 726
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
Query: 727 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 783
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
Query: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 840
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Query: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 895
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
Query: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1015
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
Query: 1016 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1070
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
Query: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1122
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
Query: 1123 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1169
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
Score = 243 bits (621), Expect = 1e-63
Identities = 308/1189 (25%), Positives = 499/1189 (41%), Gaps = 164/1189 (13%)
Query: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
Query: 178 DIDDGPNGQIEYVIQYNPDD------------PDRAQNLNERRTTTTTLTVD----VLDG 221
D D G NG+ Y + D R L + L D +
Sbjct: 175 DADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGS 234
Query: 222 DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL--NPIIVTPPIQAIDQDRNIQPP 279
+ M V + +C P+ + +P EL +P + DQ N
Sbjct: 235 SGISSMAKLTVHIEQANECAPVITAVTL----SPSELDRDPAYAIVTVDDCDQGANGDIA 290
Query: 280 SDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPVNRDFHQ-KFDLVIKAEQDNGH 336
S SI+ G R P + E + + ++ D H ++L ++A +D G
Sbjct: 291 S------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA-KDKGT 343
Query: 337 PLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAPVGATI--SDSLNLTSPLRIVA 391
P P F+ +H+ F Y+ I E AP + ++ S LR V
Sbjct: 344 P-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVF 402
Query: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 451
P F +Y T +++L+PV R++ + +T D
Sbjct: 403 -------KSTPGKAKFSLNYN----------TGLISILEPVKRQQAAHFELEVTTSDRKA 445
Query: 452 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 511
++ V ++V+ AN N P F + +Y ++ G +V+ L+AVD DEG NG +TY I
Sbjct: 446 STK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
Query: 512 LVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAADNAPPAERR-NSICTVYIEVL 569
F I+ TG ++ + ++ ++ R Y L ++A+D P R + T+ + L
Sbjct: 503 ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNL 562
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSE 628
N + P F ++ I + VG + + A D E + Y IE G+ F+L+
Sbjct: 563 ---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNP 619
Query: 629 TTGILTLGKALD---RESTDRYILIITASDGRPDGTSTATVNIVVT-------------- 671
+G+L+L ++L + L ITA+DG T +NI V
Sbjct: 620 NSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PLYINITVAASHKLVNLQCEETG 678
Query: 672 -----------------------------DVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQ 701
VN + P F LP + V E + + V
Sbjct: 679 VAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIF 738
Query: 702 VKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGA 758
+ +TD D G NG++ Y++ GN ++ F I G + L+RE D Y L + D
Sbjct: 739 MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLG 798
Query: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
+ + + L + V+D +DN P F +Y V V E+ + I+Q+EA D DLG N V+
Sbjct: 799 IPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVT 858
Query: 817 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 876
Y I + F++ TG +++ R LD E E S+ +EA D P +TV
Sbjct: 859 YSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSLK--IEARDQAREEPQLFSTVV 912
Query: 877 VIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
V V +D+ND PP F Y+ V D +GT I ++ E DP + +VRY + D
Sbjct: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWLEAHDPDLGQSGQVRYSLLD-- 968
Query: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV---- 989
+ F+V++ SG V L+ E ++ L V A D G+PV +SS+ V++ V
Sbjct: 969 --HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVN 1026
Query: 990 --LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1043
LHP F ++ V E A G++V +SA A + I YSI G+ F
Sbjct: 1027 ENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVF 1082
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
I TGVI + LD E+ + Y L V A VV S+ ++YIE++D N++
Sbjct: 1083 KIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV-------PLSSFIEIYIEVEDVNDN 1135
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV-VET 1162
P + Y + E++ SV++++A D D+ + + Y++ +GF +
Sbjct: 1136 APQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKI----TSGNPQGFFSIHP 1191
Query: 1163 YTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
TGLI T+ ++ +V TD+ S A V+V ++++ D
Sbjct: 1192 KTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
Score = 240 bits (613), Expect = 8e-63
Identities = 278/1117 (24%), Positives = 468/1117 (41%), Gaps = 119/1117 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
Query: 193 YNPD---DPDR-------AQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL----VPNTR 238
+ + D D+ Q L+ + LTV D + C + V
Sbjct: 968 DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNE 1027
Query: 239 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDY 297
+ P + + + + E+ + + A D+D R G I YSI G+
Sbjct: 1028 NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR------RDGEIRYSIRDGSGVGV 1081
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
F + T + + ++R+ + L + A PL +F ++IE+ D N+ +P
Sbjct: 1082 ---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQ 1138
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
+ P Y I+E++P ++ ++I A D D + + F++
Sbjct: 1139 TSEPVYYPEIMENSPKDVSV---------VQIEAFDPDSSSNDKLMYKITSGNPQGFFSI 1189
Query: 418 -TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPE 474
+TG+ T + +DRE+Q + +T D + I V ++++D NDN P F +
Sbjct: 1190 HPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
Query: 475 ISYDVYVYTDMRPG-------DSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTG 526
Y + + +P + + + A D DEG N EI+Y I G + G F I TG
Sbjct: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
Query: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL--PPNNQSPPRFPQLMY 584
+++ G L+++A DN P +++S ++IE + P + P F + +
Sbjct: 1308 VVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPISFEESFF 1363
Query: 585 SLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 644
+ + E+ V A ++ + + + G + + I G+ F++ + TG + + K LD E
Sbjct: 1364 TFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422
Query: 645 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 704
Y L + A+DG T V I V D ND+ P F + + + Q+ A
Sbjct: 1423 SNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISA 1480
Query: 705 TDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGA 758
D D ++ Y+L + + FR+ + GS+YT+ KL+ E + L V+ D
Sbjct: 1481 VDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD 1538
Query: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
V + + + + V D +D++P FT S+Y V E+ G+ +LQ+ A D D G N V
Sbjct: 1539 VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVL 1598
Query: 817 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 876
Y I S + + F + P G + + LD +A +V+A D I +V
Sbjct: 1599 YSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQAEYDLMVKATDKGSPPMSEITSVR 1654
Query: 877 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
+ V ++ P F+ + Y ++ G+ + V A S V Y + D
Sbjct: 1655 IFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS-------QSSVVYEIKDGN-- 1705
Query: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-- 994
F++ SG +IT+ L+ E I+ L++ G + S +LV E
Sbjct: 1706 -TGDAFDINPHSGTIITQKALDFETLPIYTLII----QGTNMAGLSTNTTVLVHLQDEND 1760
Query: 995 -IPRFTQEEYRPPPVSELATKGTMV-------GVISAAAI----NQSIVYSIVSGNEEDT 1042
P F Q EY +SE A+ ++V VI AA N +VY IV +
Sbjct: 1761 NAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTY 1819
Query: 1043 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
F I++ TG I+ LDYE + + VQ + A V + + D N+
Sbjct: 1820 FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL-----FAEYAANVTVHVIDIND 1874
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
PPVF K Y + V+ V ATD D+ +S + Y + EG + E
Sbjct: 1875 CPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSI--------TEGNIGEK 1926
Query: 1163 YTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1196
++ KT L RS ++ V A+D GL+
Sbjct: 1927 FSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
Score = 235 bits (600), Expect = 3e-61
Identities = 290/1147 (25%), Positives = 489/1147 (42%), Gaps = 163/1147 (14%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATD------IDDGP 183
E+ I V D NDN+P YY + E +P V F D+ + D P
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNP 1183
Query: 184 NG----------------------QIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG 221
G Q E++++ D N + ++T + V +LD
Sbjct: 1184 QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD-----NGSPPKSTIARVIVKILDE 1238
Query: 222 DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSD 281
+D P FL Y+ +PE P+ P I D++ P ++
Sbjct: 1239 NDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAE 1286
Query: 282 RPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQDNGHP-L 338
I YSI G ++ +FF + P+T +S ++ F ++D++ DNG P
Sbjct: 1287 ---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAVDNGRPQK 1335
Query: 339 PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 398
+ LHIE + + PS + E + T+ +S + + +++++
Sbjct: 1336 SSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVISVE----- 1383
Query: 399 TKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 454
P + L+ + +Y S F V + T + + +P+D E++ Y ++ A DG +
Sbjct: 1384 --PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEATDGT-TTI 1438
Query: 455 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 514
V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++ Y +
Sbjct: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSS 1496
Query: 515 ----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 570
+ F ++ TG + + ++ + LTV D P +R + V +
Sbjct: 1497 RDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVS--- 1553
Query: 571 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 627
N P F Y + E+ VG+V+L + A D++ + Y+IE+G+ F +
Sbjct: 1554 DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMID 1613
Query: 628 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPR 686
G + K LDR + Y L++ A+D G P + +V I VT ++ +P F +
Sbjct: 1614 PVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKF---TSK 1670
Query: 687 NLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKL 740
SV E +FVG V A V Y + GN + F I +G+I T L
Sbjct: 1671 EYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKAL 1725
Query: 741 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E+ +
Sbjct: 1726 DFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSV 1783
Query: 801 ILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
+L I A D D +N + Y I P V +FA+ TG + + SLDYE +
Sbjct: 1784 VLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE----E 1839
Query: 852 EASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 908
+ F V+ D+ GT A VTV V D+ND PPVF+K +Y+ + KG +
Sbjct: 1840 TSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKV 1898
Query: 909 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 968
TV A DAD S++ Y + + F ++ +G + V + + ++L
Sbjct: 1899 ITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQLRSRYELT 1951
Query: 969 VVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAA-- 1025
V A D + +VKI V E +FTQ+ Y V E +T+ + VI+A
Sbjct: 1952 VRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAVITAIGNP 2007
Query: 1026 INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRV 1084
IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +VV+
Sbjct: 2008 INEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDVVVEVTEE 2056
Query: 1085 PSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1142
S A V ++ ++D+N++ PVF Y V D + + V A D+D+G +
Sbjct: 2057 HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEV 2116
Query: 1143 AYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1201
Y L KE E F + + +K + + Y V+A D S + V
Sbjct: 2117 HYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPAFSAEVIV 2170
Query: 1202 LVSVVNQ 1208
++V+N+
Sbjct: 2171 PITVMNK 2177
Score = 230 bits (586), Expect = 1e-59
Identities = 284/1181 (24%), Positives = 485/1181 (41%), Gaps = 164/1181 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 191 I------QYNPDDPDRAQ-----NLNERRTTTTTLTVDVLDGDDLGPMFL-------PCV 232
I Y D +L+ T+ TV V D+G L V
Sbjct: 1811 IVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQV---HDMGTPRLFAEYAANVTV 1867
Query: 233 LVPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYS 288
V + DC P+ Y+A+ L P ++T + A D D S ++YS
Sbjct: 1868 HVIDINDCPPVFAKPLYEAS---LLLPTYKGVKVIT--VNATDADS-----SAFSQLIYS 1917
Query: 289 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---H 345
I G + F M +T L++ +++L ++A FAGL
Sbjct: 1918 ITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDGR------FAGLTSVK 1966
Query: 346 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 405
I + + FT Y + E++ T++ + +P+ + +P+
Sbjct: 1967 INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN----EPLFYHILNPDRR 2022
Query: 406 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP-----VIVNI 460
++ + V + T T P DRE+Q+ + + +E +P V+V +
Sbjct: 2023 FKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---TEEHKPSAVAHVVVKV 2069
Query: 461 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-------V 513
V D NDN P F + Y V D G + +TAVD D G NGE+ Y + +
Sbjct: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129
Query: 514 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
G G+ + K L T+ + Y +TV A D PA I + + N
Sbjct: 2130 GPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSAEVIVPITVM-----N 2176
Query: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGIL 633
++ P F + YS EI+E+++V + ++++QA EG + Y+I +GDP F ++ TG++
Sbjct: 2177 KAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVI 2236
Query: 634 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
+ LD E+ Y L I A+D + V+I+V D+NDN PVF ++ +V
Sbjct: 2237 NVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVF---AQQSYAVTLS 2293
Query: 694 EANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSNGSIYTAVK-LNREVR 745
EA+ V QV+ATD D+ N + Y + GN ++ F + S+ + + ++ L+ E
Sbjct: 2294 EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQS 2353
Query: 746 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 805
+ + V A DG + S + + + V D++DN P+F Y + E+ P G + ++
Sbjct: 2354 RQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK 2413
Query: 806 AKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
A D D + Y I S F + TG ++L + P +++ F
Sbjct: 2414 AYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVF- 2472
Query: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
V V V N + P F + Y+ +A +A T + V D D G+
Sbjct: 2473 ------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD-SGIYG 2525
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFDDGEPVMSS 981
+ V+D + F + E G++ T L+ E + + ++A D G V
Sbjct: 2526 HVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFC 2580
Query: 982 SATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSG 1037
+ V IL P+F +Y + A KGT V + A+ N I Y+I +
Sbjct: 2581 TVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD 2638
Query: 1038 NE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1092
+E ++ IN ++GVI L+ E T +V V S PSK +
Sbjct: 2639 SESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS----------PSKESVVL 2688
Query: 1093 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1152
VY++I P F + FY VSED + T + ++A T YS++ P
Sbjct: 2689 VYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGN---TPES 2745
Query: 1153 EGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKGLSGKADVLVSVVNQL 1209
E FV++ +G +K + +++F ++A DD+ + DV + V +
Sbjct: 2746 NRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--EMVASVDVSIQVKDAN 2803
Query: 1210 DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1250
D + + P + ++ E +PG V++
Sbjct: 2804 DNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
Score = 211 bits (538), Expect = 4e-54
Identities = 276/1174 (23%), Positives = 488/1174 (41%), Gaps = 112/1174 (9%)
Query: 111 IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
++++ V+ + K V + Y EV +V + N + P F TV E PVG+ + T
Sbjct: 996 VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 169 GFSGDNGAT-------DIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG 221
+ D A I DG +G + I + + L+ T+ LTV D
Sbjct: 1056 VSAHDEDARRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQ 1114
Query: 222 D--DLGPMFLPCVLVPNTRDCRPLTYQAA-IPEL--RTPEELNPIIVTPPIQAIDQDRNI 276
L + V + D P T + PE+ +P++++ + I+A D D
Sbjct: 1115 GVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV----QIEAFDPD--- 1167
Query: 277 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL-EPVNRDFHQKFDLVIKAEQDNG 335
S ++Y I G P+ FF +HP+T ++ ++R+ + L + +
Sbjct: 1168 --SSSNDKLMYKITSGNPQG---FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGS 1222
Query: 336 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDK 394
P A + ++ILDEN+ P F Y+ + E + PL ++A DK
Sbjct: 1223 PPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD---RERNARREPLYHVIATDK 1279
Query: 395 DIEDTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 451
D + + E+ + N++ F +TG+ + + SI A D +
Sbjct: 1280 D--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD-----ILSIKAVDNGR 1332
Query: 452 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DMRPGDSVIQLTAVDADEGSNGEITYE 510
+ + + + P+ IS++ +T + D V + V + E + ++
Sbjct: 1333 PQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFD 1392
Query: 511 ILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
I G F ++K TG I +A ++ Y LTV+A D + V+I+V+
Sbjct: 1393 ITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT-----TTILTQVFIKVI 1447
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENG-DP--QRVFN 625
N+ P+F Y + I E +L + A D+ E + + Y +++ DP + F
Sbjct: 1448 DTNDHR-PQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFR 1506
Query: 626 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 684
L TG L + LD E+ ++ L + D P + A + + V+D ND+AP F
Sbjct: 1507 LDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASS 1566
Query: 685 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLN 741
+ + V QV A D D G N +V YS+ GN N F I GSI TA +L+
Sbjct: 1567 YKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD 1626
Query: 742 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 801
R + Y+L+V ATD P ++ I V D+ SP FT+ Y+V + E + G+ +
Sbjct: 1627 RSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFV 1686
Query: 802 LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 861
+ A ++V Y I+ F ++P +G + ++LD+E P +
Sbjct: 1687 GMVTAHS---QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP---------IYT 1734
Query: 862 FDIYGTMPPGIATVTVI---VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT-------V 911
I GT G++T T + ++D ND PVF + Y G+++ A + + T +
Sbjct: 1735 LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVI 1794
Query: 912 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
A DAD A V + V+ P + F ++ +G + T ++L+ E T+IF V
Sbjct: 1795 RAADADKDS-NALLVYHIVE----PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQV 1849
Query: 972 FDDGEPVMSS--SATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS 1029
D G P + + +A V + V+ + P + + KG V ++A + S
Sbjct: 1850 HDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSS 1909
Query: 1030 ----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1085
++YSI GN + F ++ TG + V + R+ Y L V+A
Sbjct: 1910 AFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASDGRF-------- 1959
Query: 1086 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1145
+ V I +++ F + Y V E++ ++ + A + Y
Sbjct: 1960 --AGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYH 2015
Query: 1146 LIIPPIKEGKEGFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVS 1204
++ P + F + +G++ T F ++ F V T+++ V V
Sbjct: 2016 ILNPDRR-----FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVI 2070
Query: 1205 VVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYV 1238
V +Q D + N+P V K ++ ++ RYV
Sbjct: 2071 VEDQNDNAPVFVNLPYYAVVKVDTEVGHVI-RYV 2103
Score = 210 bits (535), Expect = 9e-54
Identities = 282/1104 (25%), Positives = 471/1104 (42%), Gaps = 118/1104 (10%)
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLN---------- 205
V E PVG+++ +TD+D G NG++ Y + +D ++
Sbjct: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPL 780
Query: 206 ERRTT---TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP-LTYQAAIPELRTPEELNPI 261
+R TT T +TV L L V+V + D P ++ E+ +E++
Sbjct: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
Query: 262 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 321
I+ ++A D+D P+ + YSI+ T F + T +++ P++R+
Sbjct: 841 II--QVEATDKDLG---PNGH--VTYSIVTDTDT-----FSIDSVTGVVNIARPLDRELQ 888
Query: 322 QKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISD 379
+ L I+A F+ + +++ D N+ P F P+Y+ + E P G I
Sbjct: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI-- 946
Query: 380 SLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 439
+ + A D D+ + L L+ F V + ++ + ++Q +D E++Q
Sbjct: 947 -------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFDVDK--LSGAVRIVQQLDFEKKQV 996
Query: 440 YTFSITAFD---GVQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQL 494
Y ++ A D V S V ++V+D N+N P F V D G V+ +
Sbjct: 997 YNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTV 1056
Query: 495 TAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 553
+A D D +GEI Y I G+ G F I + TG+I + ++ Y LTV A D
Sbjct: 1057 SAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG- 1115
Query: 554 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 610
+S +YIEV N+ + P+ + +Y EI E ++ ++A D + D
Sbjct: 1116 -VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDK 1173
Query: 611 ITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 668
+ Y I +G+PQ F++ TG++ T + LDRE D +IL +T +D G P ++ A V +
Sbjct: 1174 LMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIV 1233
Query: 669 VVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL- 719
+ D NDN P F LP + E NA + V ATD D G N ++ YS+
Sbjct: 1234 KILDENDNKPQFLQKFYKIRLPER-EKPDRERNARREPLYHVIATDKDEGPNAEISYSIE 1292
Query: 720 -GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 778
GN + F I + ++ + + +Y L + A D + ST L I+ +
Sbjct: 1293 DGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKP 1351
Query: 779 S--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTG 835
S P+ F S +T V E+ P I I + G + + I F + TG
Sbjct: 1352 SLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--GIPLWFDITGGNYDSHFDVDKGTG 1409
Query: 836 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
+ + + LD E Q+++ VEA D T+ + V + V D ND+ P FS Y+
Sbjct: 1410 TIIVAKPLDAE----QKSNYNLTVEATDGTTTI---LTQVFIKVIDTNDHRPQFSTSKYE 1462
Query: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
++ D T I + A D D +++ Y + + P F ++ +G + T
Sbjct: 1463 VVIPEDTAPETEILQISAVDQD----EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSE 1518
Query: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATK 1014
L+ E L V+ D PV + A + + V + P FT Y+ V E A
Sbjct: 1519 KLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK-GRVYESAAV 1577
Query: 1015 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
G++V ++A N ++YSI SGN ++F I+ + G I LD + Y L V
Sbjct: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637
Query: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
+A + P S V I + +N P F K Y +SE + + V V
Sbjct: 1638 KA-------TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVT 1690
Query: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKT--AMLFHNMRRSYFKFQVI 1186
A + + ++ IK+G G F + ++G I T A+ F + + +I
Sbjct: 1691 AHSQSS----------VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP----IYTLI 1736
Query: 1187 ATDDYGKGLSGKADVLVSVVNQLD 1210
GLS VLV + ++ D
Sbjct: 1737 IQGTNMAGLSTNTTVLVHLQDEND 1760
Score = 179 bits (453), Expect = 3e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 373 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 429
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
Query: 430 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 488
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 489 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
Query: 549 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 603
AD + I TV+IE N +P + E+ V ++
Sbjct: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
Query: 604 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 655
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
Query: 656 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 705
G P S+ V V + PV + P N VV +A ++
Sbjct: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
Query: 706 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
Query: 766 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 823
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
Query: 824 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 879
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
Query: 880 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 939
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
Query: 940 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 972
F + +SG + IT + T ++ + VA
Sbjct: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
Query: 973 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1014
+ G M + ++ LH GE IP+F V E
Sbjct: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
Query: 1015 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
Query: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1190
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
Query: 1191 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1232
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
Score = 169 bits (429), Expect = 2e-41
Identities = 180/649 (27%), Positives = 280/649 (43%), Gaps = 62/649 (9%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
Query: 192 -------QYNPDDPDRAQN--LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 242
+ NPD + + L+ L V DG G F +V D
Sbjct: 3064 GSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDG---GGRFCQASIVLTLEDVND 3120
Query: 243 LT--YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
+ A + E P + +QA D D + ILYS++
Sbjct: 3121 NAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRK-----ILYSLIDSADGQ---- 3171
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILDENNQSPYF 358
F ++ + + L +P++R+ + L +KA D G P L A + + +LD N+ P F
Sbjct: 3172 FSINELSGIIQLEKPLDRELQAVYTLSLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVF 3230
Query: 359 TMPSYQGYILESAPVGATISDSLNL-TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
Y GAT+S+ + + T L++ A +DIE + + + F++
Sbjct: 3231 EYREY----------GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSI 3280
Query: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEI 475
T + +++ +D E Y ++ A DG S + VN+ V D NDNTP F +
Sbjct: 3281 DSK--TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQD 3338
Query: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGV 534
+Y + D SVI + A DAD SN I Y I+ G QG F I+ G + + +
Sbjct: 3339 TYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLL 3398
Query: 535 EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 594
+ Y LTVQA+DN P R + TV I+V N+ +P F + YS+ I E V
Sbjct: 3399 DRETISGYTLTVQASDNGSPP--RVNTTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPV 3455
Query: 595 GAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
G +L L TD + G + I G+ ++ F ++ G+L A+ R+ D Y+L
Sbjct: 3456 GFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQ 3514
Query: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 709
+ +D G+P +S ++I V + + P P S EE + +G++ ATD D
Sbjct: 3515 VKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQD- 3573
Query: 710 GINGQVHYSLG-NFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG 757
+ + YSL +NLF ++S G A K ++ Y L V TDG
Sbjct: 3574 -VYDTLTYSLDPQMDNLFSVSSTGGKLIAHK-KLDIGQYL-LNVSVTDG 3619
Score = 129 bits (324), Expect = 3e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 316 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 375
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 376 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 435
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
Query: 436 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 486
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
Query: 487 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 541
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
Query: 542 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 594
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Query: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 654
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
Query: 655 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 714
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
Query: 715 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 770
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
Query: 771 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 830
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
Query: 831 HPFTGELSLLRSL 843
+P +G LSL RSL
Sbjct: 618 NPNSGVLSLKRSL 630
Score = 126 bits (316), Expect = 2e-28
Identities = 140/578 (24%), Positives = 237/578 (41%), Gaps = 85/578 (14%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
Query: 186 QIEYVIQYNPDDP----------------DRA-------------QNLNERRTTTTTLTV 216
+I Y + + D DR Q L R T T T+ V
Sbjct: 3159 KILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIV 3218
Query: 217 DVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 276
VLD +D P+F Y A + E + ++ T +Q R+I
Sbjct: 3219 SVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQVYAASRDI 3259
Query: 277 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 336
+ ++ I YSI+ G F + +T + ++E ++ + ++ L ++A
Sbjct: 3260 EANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP 3313
Query: 337 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 396
L A +++ + D N+ +P F+ +Y I E A + ++ I + D
Sbjct: 3314 SLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV-----------ITVMADDA 3362
Query: 397 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESE 454
+ + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 3363 DGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVN 3422
Query: 455 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG-EITYEILV 513
VNI V D NDN P F +Y V + + G SV+QL D D NG + I+
Sbjct: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
Query: 514 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
G G++ + ++ Y L V+ ADN P + +S+ + I V+ +
Sbjct: 3483 GNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYIDIRVIEESI 3540
Query: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--RVFNLSETT 630
P P ++ E G V+ + ATD++ D++TY++ DPQ +F++S T
Sbjct: 3541 YPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDNLFSVSSTG 3596
Query: 631 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 668
G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 3597 GKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
Score = 103 bits (256), Expect = 2e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 574 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 628
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Query: 629 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 678
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
Query: 679 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 732
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
Query: 733 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 787
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 839
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 840 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 896
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
Query: 897 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
Query: 956 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1015
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
Query: 1016 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1070
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
Query: 1071 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 1130 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1184
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
Query: 1185 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1228
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 301 bits (770), Expect = 5e-81
Identities = 329/1159 (28%), Positives = 527/1159 (45%), Gaps = 143/1159 (12%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTI-----------------FTGFSGDNGAT 177
I++ D D P F + Y + E +P GTT+ +T SG+ +
Sbjct: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI 283
Query: 178 DIDDGPNGQIEYVIQYNPDDP---------DRAQNLNERRT-----TTTTLTVDVLDGDD 223
D +G + + ++P + LN+ RT TTT + V+D +D
Sbjct: 284 FALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343
Query: 224 LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283
P F N+ + Y AI EL P+ IQ +D+D N+ S
Sbjct: 344 NAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVVDKDENLGLNS--- 384
Query: 284 GILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKFDLVIKAEQDNGHP 337
+ LVG + F + P + + + + P++ + ++D + A +
Sbjct: 385 -MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
Query: 338 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 397
+ +A + I +++EN+ P F+ P Y + E+ VG TS L ++A D D
Sbjct: 441 V-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------TSVLTVLATDNDAG 490
Query: 398 DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI 457
E+ F +D F++ + T + L+ +D E Q +T +I A DG E
Sbjct: 491 TFG--EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR 546
Query: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----V 513
V I V+D NDN PTF + +Y + + +++L A D D N +ITY I+
Sbjct: 547 VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAF 606
Query: 514 GAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
G+ D + + G+I+++ + E I LTV A D P NS V IEV
Sbjct: 607 GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPP--LNSTVPVTIEVFDE 664
Query: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG------DSITYAIENGDPQRVFN 625
N+ +PP F + Y + + E + GA +L L ATD + +SI Y++E G Q F
Sbjct: 665 ND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE-GSTQ--FR 720
Query: 626 LSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDP 682
++ +G +T LDRE+ YILI+ A DG T ATVNI + D+NDN P +
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 683 YLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VK 739
P +++VE ++ V V A DPD G NG + YS+ N + + S G I T
Sbjct: 781 -APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
Query: 740 LNREVRDYYE------LVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLV 791
L+RE D +E +VV TD P +T T+ + +LD++DN P F N + V
Sbjct: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
Query: 792 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 849
E +PAG +I Q+ A D+D G N VSYR+ + F ++ +G + LD E
Sbjct: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
Query: 850 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 909
+ + + A D +T+T+ V D+ND P F +Y V+ D + +
Sbjct: 960 EYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
Query: 910 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
+ D D GL A + Y + F V V T V L+ E T + L++
Sbjct: 1016 WLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
Query: 970 VAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAA 1025
A D+G PV + +ATV + VL + P F Q Y V E +G + + A
Sbjct: 1071 EAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATD 1128
Query: 1026 INQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLA 1080
++ + Y I+ GN + F I+ G++ PLD E +S+VL V+A + ++
Sbjct: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-- 1186
Query: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNY 1139
P +S+ +V + ++D N+ PVF ++ Y G+ E A + TSV+ V+ATD+D+G+
Sbjct: 1187 ----PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
Query: 1140 SVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1198
++ YR++ G EG F ++ TGLI T ++ + V ATD G
Sbjct: 1242 GLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
Query: 1199 ADVLVSVVNQLDMQVIVSN 1217
V ++++N+LD V SN
Sbjct: 1297 CSVYITLLNELDEAVQFSN 1315
Score = 293 bits (750), Expect = 1e-78
Identities = 313/1164 (26%), Positives = 505/1164 (43%), Gaps = 134/1164 (11%)
Query: 96 LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 149
+ +T +LDR+ P + IVV V C + V + + D NDN PTF++
Sbjct: 833 IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
Query: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-------------------V 190
+ A V E P G +I+ A D+D+G NG + Y V
Sbjct: 893 LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVV 947
Query: 191 IQYNPDDPDRAQNLNER----------RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 240
+ D +R R +++T+TLT+ VLD +D P F P V
Sbjct: 948 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV-------- 999
Query: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Y ++ E P E + + D D + + Y I G +
Sbjct: 1000 ----YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITGGNVDGK--- 1042
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEILDENNQSPYF 358
F + R A + + ++R+ + L+++A + G A + + +LD N+ P F
Sbjct: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
Query: 359 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV- 417
SY+ + E P G +I L++ A D D + + ++ + F +
Sbjct: 1103 LQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1153
Query: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 474
G+ + +P+DRE ++ + A++ G S V V + V D ND P F +
Sbjct: 1154 VSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRVIVYVEDINDEAPVFTQ 1210
Query: 475 ISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 533
Y + G SVI + A D D G G + Y IL GA+G F I+++TGLI
Sbjct: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY 1270
Query: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
++ +Y + V A D APP + C+VYI +L +++ +F Y I E +
Sbjct: 1271 LDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV-QFSNASYEAAILENLA 1327
Query: 594 VGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
+G ++ +QA + + ITY A + + +F + TG++T+ +DRE D Y L
Sbjct: 1328 LGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL 1387
Query: 650 IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708
+ A DG P ST V I V D NDN+P FD +S+ E+ V VKA DPD
Sbjct: 1388 TVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
Query: 709 AGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
AG NGQV +SL GN F I S G ++ A L+RE D+Y L VVA+D PR
Sbjct: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
Query: 763 HSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI 819
L + +LDI+DN PV + Y V V EN+ GT ++Q+ A D D+G N +SY I
Sbjct: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567
Query: 820 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAFDIYGTMPPGIAT-VTV 877
F + +GE++ A PD+E S LV + GT T V V
Sbjct: 1568 TEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
Query: 878 IVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935
+ D ND P+F + Y+ ++ PD + T + T+ A D D P V Y +
Sbjct: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG--PNGTVTYAIVAGNI 1679
Query: 936 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS----SSATVKILVLH 991
+ F ++ G + L+ E + ++V D P++S S+ TV + V
Sbjct: 1680 ---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVND 1736
Query: 992 PGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGIN 1046
+ +P F ++ P V+E G V A + N + YSI+ G+ F I+
Sbjct: 1737 INDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
Query: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
+ GV+ V ++ + T + +L + + +P S+T V I + D N++ PV
Sbjct: 1796 PVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPV 1850
Query: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
+SE++ + + V V A+D D+G + + + + + F + TG+
Sbjct: 1851 LLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGI 1907
Query: 1167 IKTAMLFHNMRRSYFKFQVIATDD 1190
+ R +K + D+
Sbjct: 1908 VTVNRPLDRERIPEYKLTISVKDN 1931
Score = 283 bits (724), Expect = 1e-75
Identities = 309/1079 (28%), Positives = 479/1079 (44%), Gaps = 108/1079 (10%)
Query: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
Query: 188 EYVIQ----YNPDDPDRA-----QNLNERRTTTTTLTVDVLDGDDLGPMFLPC---VLVP 235
Y Q + D R + L+ T LTV+ D D P+ +++
Sbjct: 168 LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
Query: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPP------IQAIDQDRNIQPPSDRP-GILYS 288
+ +D P+ + P N +PP I AIDQD+ RP GI Y+
Sbjct: 228 DVQDMDPIF-------INLPYSTNIYEHSPPGTTVRIITAIDQDKG------RPRGIGYT 274
Query: 289 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---- 344
I+ G ++ LL+ N + F L +K + N P+ A +
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
+I ++D N+ +P F Y I E A VG + PL I +DKD +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFAL--------PLFIQVVDKDENLGLNSMF 386
Query: 405 HLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTYTFSITAFDGVQESEPVI-V 458
++L + + F ++ T + + + P+D E Y F + A + V + V
Sbjct: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKV 446
Query: 459 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 518
I +++ NDN P F + Y++ +Y ++ G SV+ + A D D G+ GE++Y
Sbjct: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR 505
Query: 519 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
F ++K TGLI + ++ + + + LT+ A D + V I VL N+ + P
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEETTGRVRINVLDVND-NVPT 560
Query: 579 FPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF---NLSETTGI 632
F + Y + E L+ L+ATD + + ITY+I + + +L E G+
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 633 LTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD--PYLPRN 687
+++ + LD E Y+ ++ G P ST V I V D NDN P F Y
Sbjct: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF--- 677
Query: 688 LSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNNLFRITS-NGSIYTAVKLNR 742
+SVVE A A V + ATD D GQ + YSL + FRI + +G I T L+R
Sbjct: 678 VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-STQFRINARSGEITTTSLLDR 736
Query: 743 EVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
E + Y L+V A DG V T T+ I +LDI+DN P + ++ Y + + E P +
Sbjct: 737 ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796
Query: 801 ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS-LDYEAFPDQEASITF 857
+ + A D DLG N + Y I+ P F++L+ TG++ + LD E EA +
Sbjct: 797 VTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
Query: 858 LVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 913
+ PP ATV V + D+ND P F + V G I V A
Sbjct: 855 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
Query: 914 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 973
D D GL V YR + P F + SG V+T L+ E ++L VVA D
Sbjct: 915 IDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
Query: 974 DGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATKGTMVGV---ISAAAINQS 1029
G P SS++T+ I VL E P F Y ++ + +V + + +N
Sbjct: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
Query: 1030 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-S 1088
+ Y I GN + F + V+ LD ET +Y+L ++A + N V + +
Sbjct: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA------IDNGPVGKRHT 1083
Query: 1089 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
TA V++ + D N++ P+F + Y V ED S+L++KATD D G + + YR++
Sbjct: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
Score = 278 bits (712), Expect = 3e-74
Identities = 348/1338 (26%), Positives = 584/1338 (43%), Gaps = 164/1338 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNI- 1890
Query: 193 YNPDDPDRA-------------QNLNERRTTTTTLTVDVLDGDDLGPMF------LPCVL 233
+ +RA + L+ R LT+ V D + P L +
Sbjct: 1891 -TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPE-NPRIARRDYDLLLIF 1948
Query: 234 VPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
+ + D PL TYQA + E +P ++ PI A+D D++I ++
Sbjct: 1949 LSDENDNHPLFTKSTYQAEVME-NSPAGTPLTVLNGPILALDADQDIY------AVVTYQ 2001
Query: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF-----DLVIKAEQDNGHPLPAFAGL 344
L+G F ++ T +++ V D + F +L++ AE D G L + A L
Sbjct: 2002 LLGAQSG---LFDINSSTGVVTVRSGVIID-REAFSPPILELLLLAE-DIGL-LNSTAHL 2055
Query: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
I ILD+N+ P F+ + ++LE+ P G ++ L++ A D+D +
Sbjct: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTATDEDSGLNGELVY 2106
Query: 405 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQV 462
+ TG+ R +DREEQ++Y ++ A D V S IV I +
Sbjct: 2107 RIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTVPLSGTAIVTILI 2164
Query: 463 MDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI----------- 511
D ND+ P F V V PG + +TA+D D N ++ Y I
Sbjct: 2165 DDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDR 2222
Query: 512 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ERRNSI--CTVYIE 567
LV Q D F +N TG + + + + TY +T+ DNA ER S+ + +
Sbjct: 2223 LVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVN 2282
Query: 568 VLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQR 622
VL N+ +P P + Y +E I E G L+ + A D + +TY + + P
Sbjct: 2283 VLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPG 2342
Query: 623 VFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF 680
L +++ G + + +D E + ASD G P + V + + D+NDN P+F
Sbjct: 2343 YVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIF 2402
Query: 681 DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVK 739
D + + + V ATD D+G + YSLG+ + F I + G IY
Sbjct: 2403 DQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSS 2462
Query: 740 LNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 795
L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+ ++ V EN
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
Query: 796 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQE 852
PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R L YE F
Sbjct: 2523 PAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF---- 2577
Query: 853 ASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPI 908
+ V A D G PP G + V V D+ND PVF + + + + + +
Sbjct: 2578 ---SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNV 2632
Query: 909 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 968
VYA D D GL + VRY F ++ SG + T L+ E ++ L+
Sbjct: 2633 YEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLI 2690
Query: 969 VVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVI 1021
+VA D G+PV + + L P F + +Y+ V E + +GT+VG +
Sbjct: 2691 LVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV 2750
Query: 1022 SAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1076
+ A N + Y I +GNEE F + G + V LD E + V+A S
Sbjct: 2751 TGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNR 2809
Query: 1077 VVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
L + + +V + ++D N+ PP F K Y GV+ DA++ + +++V
Sbjct: 2810 SWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVL 2869
Query: 1131 ATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1182
A D D GN YS++A +R + ++ + F + + G+++T LF YF
Sbjct: 2870 ALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFV 2929
Query: 1183 FQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQ 1239
++A D L+G D + + L D +V IV N P V E+ +L
Sbjct: 2930 VDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL----- 2979
Query: 1240 EQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLD 1299
I GA +V + + H D ++ + +L ++ ++ TNR +D + + + +D
Sbjct: 2980 SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQ 3037
Query: 1300 INKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVL 1359
+ F+ Y +L+++ +V + + + + A++ LA ++ L A+L VL
Sbjct: 3038 LRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVL 3085
Query: 1360 VSYRQRQAECTKTARIQA 1377
+++ R K I A
Sbjct: 3086 MNWYYRTVHKRKLKAIVA 3103
Score = 276 bits (705), Expect = 2e-73
Identities = 334/1235 (27%), Positives = 520/1235 (42%), Gaps = 134/1235 (10%)
Query: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
Query: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
Query: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIE-YVIQYNPD----DPDRAQ 202
Y + EL VG + D D+ G N E Y++ N P Q
Sbjct: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
Query: 203 NLNERRTTTTTL----TVDVLDGDDLGPMFLPC--------VLVPNTRDCRPLTYQAAIP 250
+ R TVD D D +P + + N D RP+ Q P
Sbjct: 407 GKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQ---P 463
Query: 251 ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL 310
N + T + + D + + + Y D P F + T +
Sbjct: 464 LYNISLYENVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLI 515
Query: 311 SLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 370
L+ ++ + Q+F L I A G + I +LD N+ P F +Y G + E+
Sbjct: 516 MLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALREN 573
Query: 371 APVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLL 429
P ++T +R+ A D+D + + + S F ++ +++
Sbjct: 574 EP---------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVS 624
Query: 430 QPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDM 485
+P+D E+ +T + P V V I+V D NDN PTF + +Y V V ++
Sbjct: 625 RPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
Query: 486 RPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTY 542
G +V+ L A D D E I Y + Q F IN +G IT ++ Y
Sbjct: 685 MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY 742
Query: 543 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQ 602
L V+A D ++ I TV I +L N+ P + Y + + E + + +
Sbjct: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVV 801
Query: 603 ATDR---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILII 651
A D E ++ Y+I+ P + ++L+ TTG I T LDRE+ D R I++
Sbjct: 802 AVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 859
Query: 652 TASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708
GRP TS+ATV + + D+NDN P F LP V+E A + QV A D D
Sbjct: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLD 918
Query: 709 AGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
G+NG V Y + G F I +S+G + T +L+RE Y+L VVA+D + ST
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
Query: 766 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 823
TL I VLD++D +P F + Y V V E++P ++ + D D+G N +SY I
Sbjct: 979 STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
Query: 824 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKD 881
V F++ + + LD E A+ ++EA D G G ATV V V D
Sbjct: 1039 VDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
Query: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
+ND P+F + Y+ V D +G I + A DAD RV YR + +
Sbjct: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNN 1149
Query: 942 FEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFT 999
F + +G ++ L+ E + L+V A++ M SS V + V E P FT
Sbjct: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1209
Query: 1000 QEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVN 1055
Q++Y + E A GT V V+ A + + Y I+SG E F I+ TG+I
Sbjct: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITV 1268
Query: 1056 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1115
LDYET+TSY++ V A + P VYI + +E + F Y
Sbjct: 1269 NYLDYETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
Query: 1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1175
+ E+ + T ++RV+A D N + + YR + K F ++ TG+I L
Sbjct: 1322 ILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
Query: 1176 MRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
+ ++ V+A DD G + V ++V+++ D
Sbjct: 1380 EKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
Score = 261 bits (666), Expect = 6e-69
Identities = 307/1154 (26%), Positives = 501/1154 (43%), Gaps = 133/1154 (11%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
Query: 191 IQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 250
+ + + + + + LD ++L L V R + +
Sbjct: 1458 LA-SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
Query: 251 ELRTPEELNPIIVTPP-------------------IQAIDQDRNIQPPSDRPGILYSILV 291
L + NP ++ P ++A D+D I + Y I
Sbjct: 1517 ILDIND--NPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV-----LSYYITE 1569
Query: 292 GTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 350
G + F M + E++ P +R+ + LV E + L A +++ I+D
Sbjct: 1570 GNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626
Query: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
EN+ +P F P Y+ +L+ P D+LN TS + I ALD D + +
Sbjct: 1627 ENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLITIQALDLDEGPNGTVTYAIVAGN 1678
Query: 411 YTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSITAFDG-------VQESEPVIVNIQ 461
+ F + + G+ +T + +D E YT +TA D + + V+VN+
Sbjct: 1679 IVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVN 1735
Query: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFI 520
D NDN PTFP + T+ +PG V A D D G NG++ Y I+ G G+F+
Sbjct: 1736 --DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
Query: 521 INKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
I+ G++ + VE+ Y LT+ A D P +S V I VL N+ P
Sbjct: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVL 1851
Query: 579 FPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTL 635
L ++ ISE V + + ++ A+D + +T+ I G+ +R F ++ TTGI+T+
Sbjct: 1852 L-NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV 1910
Query: 636 GKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPRNLSV 690
+ LDRE Y L I+ D P+ A + I ++D NDN P+F + +
Sbjct: 1911 NRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVM 1969
Query: 691 VEEEANAFV----GQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTA---VKLNR 742
A + G + A D D I V Y L G + LF I S+ + T V ++R
Sbjct: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029
Query: 743 EVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
E EL+++A D + +ST L I +LD +DN P F+ +T TV + EN P G +
Sbjct: 2030 EAFSPPILELLLLAED--IGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFS 2087
Query: 801 ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 858
+LQ+ A D D G N + YRI + F +H TG ++R + +++ S
Sbjct: 2088 VLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG---VIRVGNATIDREEQESYRLT 2143
Query: 859 VEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917
V A D GT+P G A VT+++ D+ND P F I V A GT I + A D D
Sbjct: 2144 VVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
Query: 918 PPGLPASRVRYRV------DDVQ--FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
++ Y + DD P F V ++G V+ + +N E +++ +
Sbjct: 2203 LN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTL 2258
Query: 970 VAFDDGEP-------VMSSSATVKILVLHPGEIPRFTQE--EYRPPPVSELATKGTMVGV 1020
D+ V ++ TV +L ++ P+F Y + E AT GT +
Sbjct: 2259 SVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFKPFGITYYMERILEGATPGTTLIA 2317
Query: 1021 ISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVIYVNGPLDYETRTSYVLRVQADSL 1075
++A +N + Y+++ + + + G + N +DYE V +
Sbjct: 2318 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE-------EVHWLNF 2370
Query: 1076 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1135
V ++ P ++ VY+EI D N++ P+F + Y V ED + T +L V ATD D
Sbjct: 2371 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2430
Query: 1136 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1195
+GN++++ Y L +G+ F + TG I ++ ++ +A D+ G
Sbjct: 2431 SGNFALIEYSL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2485
Query: 1196 SGKADVLVSVVNQL 1209
S + + V VV Q+
Sbjct: 2486 SNRRENSVQVVIQV 2499
Score = 252 bits (644), Expect = 2e-66
Identities = 299/1100 (27%), Positives = 476/1100 (43%), Gaps = 151/1100 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
V + V D NDN PTF + Y E+T G ++T + D D GPNGQ+EY
Sbjct: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
Query: 191 IQYNPDDP---------------DRAQNLNERRTTTTTLTVDVLDGD--DLGPMFLPCVL 233
I DP + L+ LT+ D L L +
Sbjct: 1783 IM--DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
Query: 234 VPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAIDQDRNIQPPSDRPGILYSILVG 292
V + D P+ +P T E +P+ + A D D + ++I G
Sbjct: 1841 VLDINDNDPVLLN--LPMNITISENSPVSSFVAHVLASDADSGCNAR-----LTFNITAG 1893
Query: 293 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA---FAGLHIEIL 349
E R F ++ T +++ P++R+ ++ L I + + +P A + L I +
Sbjct: 1894 NRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
Query: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL----- 404
DEN+ P FT +YQ ++E++P G ++ L P+ + D+DI +L
Sbjct: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPILALDADQDIYAVVTYQLLGAQS 2007
Query: 405 HLF-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV-IVN--- 459
LF +N T V TV ++G+ +DRE FS + + +E + ++N
Sbjct: 2008 GLFDINSSTGVVTV-RSGVI--------IDRE-----AFSPPILELLLLAEDIGLLNSTA 2053
Query: 460 ---IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 516
I ++D NDN PTF + V++ + PG SV+Q+TA D D G NGE+ Y I GAQ
Sbjct: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
Query: 517 GDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 575
F+I+ TG+I + ++ +Y LTV A D +I T+ I+ + N S
Sbjct: 2114 DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI---NDS 2170
Query: 576 PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD-----SITYAIENGDPQRV------- 623
P F + ++ + E+ G V+ N+ A D + + I + D R+
Sbjct: 2171 RPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDA 2230
Query: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPD------GTSTATVNIVVTDVNDNA 677
F ++ TG + + ++RE Y + ++ D D A + + V DVNDN
Sbjct: 2231 FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT 2290
Query: 678 PVFDP-----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNG 732
P F P Y+ R L V A DPD G+NG V Y+L + +
Sbjct: 2291 PQFKPFGITYYMERILEGATPGTTLIA--VAAVDPDKGLNGLVTYTLLDLVPPGYVQLED 2348
Query: 733 SIYTAVKLNREVRDYYEL-----VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
S V NR V DY E+ V A+D PR + + + ++++DI+DN+P+F +Y
Sbjct: 2349 SSAGKVIANRTV-DYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
Query: 788 TVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 845
V E++P GT IL + A D D G A + Y + E K FA++P TG++ +L SLD
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDR 2465
Query: 846 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 905
E + D+ V + V D+ND P FSK + V + G
Sbjct: 2466 EKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAG 2525
Query: 906 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 965
T + T+ A D D P + Y ++ F V+ DSG V T+ L F
Sbjct: 2526 TSVITMMATDQDEG--PNGELTYSLEGP----GVEAFHVDMDSGLVTTQRPLQSYEK--F 2577
Query: 966 KLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS------ELATKGTMV 1018
L VVA D GEP + + + + V+ + P F RPP + E+ + +
Sbjct: 2578 SLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV----RPPNGTILHIREEIPLRSNVY 2633
Query: 1019 GVISA---AAINQSIVYSIV--SGNEE-DTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
V + +N ++ YS + +GN + + F I+ I+G+I LD E++ Y
Sbjct: 2634 EVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY------ 2687
Query: 1073 DSLEVVLANLRVPSKSNT---AKVYIEIQDENN----HPPVFQKKFYIGGVSEDARMFTS 1125
SL +V ++L P T +V +E D+N PP ++ + V E + T
Sbjct: 2688 -SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
Query: 1126 VLRVK-ATDKDTGNYSVMAY 1144
V V A D D G +++ Y
Sbjct: 2747 VGNVTGAVDADEGPNAIVYY 2766
Score = 223 bits (568), Expect = 1e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 353 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
Query: 411 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 468
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
Query: 469 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 528
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
Query: 529 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
Query: 587 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 644 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
Query: 696 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 743
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
Query: 744 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 803 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 860
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
Query: 861 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 920
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
Query: 921 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 976
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
Query: 977 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1032
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
Query: 1033 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1091
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
Query: 1092 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1151
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
Query: 1152 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1202
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
Query: 1203 VSVVNQLDMQVIVSNVP 1219
V++++ D N+P
Sbjct: 878 VNLLDLNDNDPTFQNLP 894
Score = 213 bits (542), Expect = 1e-54
Identities = 272/1042 (26%), Positives = 440/1042 (42%), Gaps = 146/1042 (14%)
Query: 91 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
Query: 144 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQN 203
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL---GAQSGLFD 2011
Query: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVL-----------------VPNTRDCRPLTYQ 246
+N T + ++D + P L +L + + D RP T+
Sbjct: 2012 INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRP-TFS 2070
Query: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPR 306
A + E P + A D+D + ++Y I G + F +H
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGE-----LVYRIEAGAQDR----FLIHLV 2121
Query: 307 TAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG 365
T + + ++R+ + + L + A PL A + I I D N+ P F P
Sbjct: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 366 YILESAPVGATISDSLNLTSPLRIVALDKDIED----------TKDPELHLFLNDYTSVF 415
+LESA G I++ I A+D D+ KD L N +
Sbjct: 2182 SVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
Query: 416 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE------SEP-VIVNIQVMDANDN 468
TG + + P++RE TY +++ D + S P + + V+D NDN
Sbjct: 2233 VNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
Query: 469 TPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI--INK 523
TP F Y + PG ++I + AVD D+G NG +TY +L ++ +
Sbjct: 2290 TPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
Query: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
+ G + V+ TV+A+DN P R + VY+E++ N+ + P F Q
Sbjct: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIPVYLEIVDINDNN-PIFDQPS 2406
Query: 584 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALD 640
Y + E + VG ++L + ATD + + I Y++ GD + F ++ TTG + + +LD
Sbjct: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLD 2464
Query: 641 RESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPR-NLSVVEEE 694
RE D YIL A D D S N I V DVND P F P+ + SV E E
Sbjct: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK--PQFSTSVYENE 2522
Query: 695 -ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTAVKLNREVRDY--YEL 750
A V + ATD D G NG++ YSL G F + + + T R ++ Y + L
Sbjct: 2523 PAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT---QRPLQSYEKFSL 2579
Query: 751 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTVL-VEENLPAGTTILQIEAKD 808
VVATDG P T L ++V+D++DN PVF T+L + E +P + + ++ A D
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 809 VDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
D G N + R + FF + P +G + + LD E+ +A + ++ A D
Sbjct: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES----QAVYSLILVASD 2695
Query: 864 I-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRIYKGMVAPD-AVKGTPITTVY 912
+ Y TM P + V ++D++D P+F Y+ + P+ + +GT + V
Sbjct: 2696 LGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVT 2751
Query: 913 -AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
A DAD P + V Y + F ++ D ++ R +L+ E IF +V A
Sbjct: 2752 GAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLLVLR-DLDREREAIFSFIVKA 2805
Query: 972 FDDGE--PVMSSSATVKI---LVLHPGEI---------PRFTQEEYRPPPVSELATKGTM 1017
+ P S T+ + L L + PRFT+ EY ++ +
Sbjct: 2806 SSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSEL 2865
Query: 1018 VGVISAAA---INQSIVYSIVS 1036
+ V++ A N + YSI++
Sbjct: 2866 IQVLALDADIGNNSLVFYSILA 2887
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 292 bits (747), Expect = 2e-78
Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)
Query: 353 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 406
N +P F PSYQ + E+ P G ++ + A+D D +E T D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
Query: 407 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 464
N + S+ VT +T + +DRE + T+ F +TA D + S + I V D
Sbjct: 227 RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
Query: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 520
ND+ P F + Y + ++ G V+ + A D D N I Y +L G+ G F
Sbjct: 282 TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
Query: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
I+ +G+I V+ +Y LTV+A+D R++ V++ V +N + P+F
Sbjct: 342 IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 637
+ Y +++ E + GA +L + A+DR+ S + Y+I +G+ + F L TG L +
Sbjct: 401 EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
Query: 638 ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
LD E+T Y L + A DG P + V + V D+NDNAP+F P +V+E
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
Query: 696 NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 751
+ V V+A D DAG N ++ Y L + F T N G I A +L+RE D+Y
Sbjct: 520 LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
Query: 752 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 811
V A D ++ ++++ VLD++DN+P FT YTV + E+ GT+++ + A D D
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
Query: 812 GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 869
+ ++Y+I S ++ F++ +G +SL LDY+ E V A D GT
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
Query: 870 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 929
A + V V D N + PVF Y V D GT + + A D D +R+ Y
Sbjct: 693 QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
Query: 930 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 989
++D P F ++ D+G V T+ L+ E + L + A D+G P S + ++ILV
Sbjct: 751 MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 990 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1043
+ P+F ++ Y+ V E T V ISA + +N + Y+ G++ D F
Sbjct: 806 NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
Query: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
+ + +G++ LD E YVLR A + +P +V + + D N++
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
PPVF++ + V E++ + +V RV ATD D G + + Y+++ I E F ++ +
Sbjct: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
+G + + R + + AT L +A V V ++++ D ++ N
Sbjct: 975 SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
Score = 283 bits (724), Expect = 1e-75
Identities = 266/894 (29%), Positives = 401/894 (44%), Gaps = 81/894 (9%)
Query: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 299
+P +YQA +PE N TP + R I P G L Y++ +
Sbjct: 182 QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 358
FF + P T ++ E ++R+ + A QD+G P A A L I + D N+ P F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 359 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---VF 415
Y+ + E+ VG + L + A D D + L S VF
Sbjct: 290 EQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340
Query: 416 TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTP 470
+ ++G+ R PVDREE ++Y ++ A D ++ P V + V D NDN P
Sbjct: 341 EIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP 397
Query: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 529
F E Y V V D+ PG V+++TA D D+GSN + Y I+ G A+G F ++ TG +
Sbjct: 398 QFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALD 457
Query: 530 IAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 588
+ ++ + Y L V+A D PP + + TV + + N + P F + +
Sbjct: 458 VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQATV 514
Query: 589 SEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 645
E++ +G ++L++QA D + GD+ + Y + F ++ TG +++ LDRE D
Sbjct: 515 LESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD 574
Query: 646 RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQV 702
Y + A D G P T++A+V++ V DVNDN P F P + E+A V V
Sbjct: 575 FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVTV 632
Query: 703 KATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGAV 759
A D DA + GN N F ITS G + A+ L+ ++ Y L V A+DG
Sbjct: 633 SAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT- 691
Query: 760 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI 819
R T + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N
Sbjct: 692 --RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
Query: 820 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 879
+ F + TG ++ LDYE + S T + A D + ++V
Sbjct: 750 FMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 880 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFP 936
D+ND P F + Y+G V D T + + A D D GL RV Y DD
Sbjct: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD-- 861
Query: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 996
F VE SG V T L+ E + L A D G P + V + VL + P
Sbjct: 862 ---GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
Query: 997 RFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVI 1052
+++ V E + G V ++A N I+Y IV GN + F ++ +G +
Sbjct: 919 PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978
Query: 1053 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
LDYE R YVL +QA S +V + A V++ + D N++PPV
Sbjct: 979 TALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
Score = 279 bits (713), Expect = 2e-74
Identities = 270/963 (28%), Positives = 443/963 (46%), Gaps = 85/963 (8%)
Query: 138 RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI----- 191
R RN N+ P F+ SY ATV E P GT + A D D+G G++EY +
Sbjct: 171 RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMDALFD 225
Query: 192 ----QYNPDDP-----DRAQNLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDC 240
Q+ DP A+ L+ +T V D + +LV +T D
Sbjct: 226 SRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDH 285
Query: 241 RPLTYQAAIPE-LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 299
P+ Q E LR E+ ++T ++A D D PP+ ILY +L G+
Sbjct: 286 DPVFEQQEYKESLRENLEVGYEVLT--VRATDGD---APPN--ANILYRLLEGSGGSPSE 338
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDENNQSPY 357
F + PR+ + PV+R+ + + L ++A P P A + + + D+N+ +P
Sbjct: 339 VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
F+ Y + E GA + LR+ A D+D + + F +
Sbjct: 399 FSEKRYVVQVREDVTPGAPV---------LRVTASDRDKGSNAVVHYSIMSGNARGQFYL 449
Query: 418 -TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMDANDNTPTFP 473
QTG L ++ P+D E + YT + A DG + + +V +QV+D NDN P F
Sbjct: 450 DAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFV 506
Query: 474 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAP 532
+ V + G V+ + A+DAD G N + Y + VG F IN TG I++A
Sbjct: 507 STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA 566
Query: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
++ Y+ V+A D+ PA ++ +V + + NN P F Q Y++ ++E
Sbjct: 567 ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNN---PTFTQPEYTVRLNEDA 623
Query: 593 RVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDRYIL 649
VG ++ + A DR+ S ITY I +G+ + F+++ + G+++L LD + +Y+L
Sbjct: 624 AVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVL 683
Query: 650 IITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPD 708
+TASDG T+ VN VTD N + PVF + N++ + A V + ATD D
Sbjct: 684 AVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNVN-EDRPAGTTVVLISATDED 740
Query: 709 AGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT 767
G N ++ Y + + FRI ++ G++ T +L+ E + Y L + A D + + T
Sbjct: 741 TGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY 800
Query: 768 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR-SPEV 824
L I V D++DN+P F +Y V E++P T++LQI A D D G N V Y + +
Sbjct: 801 LEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDG 860
Query: 825 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA--TVTVIVKDM 882
F + +G + LR L D+E +++ A+ + MPP VTV V D+
Sbjct: 861 DGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDV 914
Query: 883 NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIF 942
ND PPVF + + V ++ G + V A D D +++ Y++ + P +F
Sbjct: 915 NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--TNAQIMYQIVEGNIP---EVF 969
Query: 943 EVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL----HPGEIPRF 998
+++ SG + V+L+ E + LV+ A P++ S ATV + +L +P + F
Sbjct: 970 QLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SRATVHVRLLDRNDNPPVLGNF 1026
Query: 999 TQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1056
+ G +G + A I+ S+ YS GNE +N TG + ++
Sbjct: 1027 EILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSR 1086
Query: 1057 PLD 1059
LD
Sbjct: 1087 ALD 1089
Score = 275 bits (702), Expect = 4e-73
Identities = 254/897 (28%), Positives = 404/897 (45%), Gaps = 104/897 (11%)
Query: 39 PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95
PP+ + E GT + I +G AG + T++ + + +DPV +
Sbjct: 183 PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
Query: 96 LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154
+T LDR+ ++ + Q + ++ + I+V D ND+ P F+ + Y
Sbjct: 242 --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
Query: 155 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPDRAQNLNERRTTTTT 213
++ E VG + T ATD D PN I Y +++ + P ++ R T
Sbjct: 297 SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 214 -------------LTVDVLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE--LRTPEE 257
LTV+ D G D GP + + D Q + ++ E+
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 258 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 317
+ P + A D+D+ + YSI+ G F++ +T L ++ P++
Sbjct: 412 VTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARGQ---FYLDAQTGALDVVSPLD 463
Query: 318 RDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGAT 376
+ +++ L ++A+ PL +GL +++LD N+ +P F +Q +LES P+G
Sbjct: 464 YETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523
Query: 377 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 436
+ L + A+D D D E L + FT+ T ++++ +DREE
Sbjct: 524 V---------LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNG--TGWISVAAELDREE 572
Query: 437 QQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 491
Y+F + A D P + V++ V+D NDN PTF + Y V + D G SV
Sbjct: 573 VDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSV 629
Query: 492 IQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQA 548
+ ++AVD D ++ ITY+I G + F I + GL+++A ++ + R Y L V A
Sbjct: 630 VTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTA 687
Query: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-- 606
+D R + + V N P F Y++ ++E G ++ + ATD
Sbjct: 688 SDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVNVNEDRPAGTTVVLISATDEDT 741
Query: 607 -EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTA 664
E ITY +E+ PQ F + TG +T LD E Y L ITA D G P + T
Sbjct: 742 GENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTT 799
Query: 665 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--VGQVKATDPDAGINGQVHYSL- 719
+ I+V DVNDNAP F D Y V E+ F V Q+ ATD D+G+NG+V Y+
Sbjct: 800 YLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
Query: 720 ----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 775
G+ + + TS G + T +L+RE Y L A D + P + + + + VLD+
Sbjct: 856 GGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDV 914
Query: 776 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPF 833
+DN PVF + V VEEN P G + ++ A D D G N + Y+I + F L F
Sbjct: 915 NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIF 974
Query: 834 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPV 888
+GEL+ L LDYE P+ I T P ++ TV V+ D ND PPV
Sbjct: 975 SGELTALVDLDYEDRPEY---------VLVIQATSAPLVSRATVHVRLLDRNDNPPV 1022
Score = 218 bits (556), Expect = 3e-56
Identities = 214/760 (28%), Positives = 331/760 (43%), Gaps = 103/760 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
V + V D NDN+P F + Y V E G + A+D D G N + Y I
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
Query: 192 ------QYNPDDP----DRAQNLNERRTTTTTL-------------------TVDVLDGD 222
Q+ D D L+ T TL TV VLD +
Sbjct: 440 SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDIN 499
Query: 223 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 282
D P+F+ + PL Y + +QAID D D
Sbjct: 500 DNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG-----DN 537
Query: 283 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAF 341
+ Y L G D+P F ++ T +S+ ++R+ + ++A +D+G P L A
Sbjct: 538 ARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHGTPALTAS 593
Query: 342 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 401
A + + +LD N+ +P FT P Y + E A VG TS + + A+D+D
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDRDAHSV-- 642
Query: 402 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 461
+ + + F++T ++L P+D + ++ Y ++TA DG ++ IV +
Sbjct: 643 ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIV-VN 701
Query: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 521
V DAN + P F Y V V D G +V+ ++A D D G N ITY + + F I
Sbjct: 702 VTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMEDSIPQFRI 760
Query: 522 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFP 580
+ TG +T ++ +Y L + A DN P + T Y+E+L + N + P+F
Sbjct: 761 DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVNDNAPQFL 816
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLG 636
+ Y + E + +L + ATDR+ + Y + GD F + T+GI+
Sbjct: 817 RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
Query: 637 KALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
+ LDRE+ +Y+L A D G P + V + V DVNDN PVF+ V EE
Sbjct: 877 RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEFDVFVEEN 933
Query: 696 NAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 749
+ V +V ATDPD G N Q+ Y + GN +F++ +G + V L+ E R Y
Sbjct: 934 SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYV 993
Query: 750 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 804
LV+ AT P S T+ +++LD +DN PV N + Y + P G I ++
Sbjct: 994 LVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRV 1049
Query: 805 EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 844
A D D+ +++Y L+ TGEL L R+LD
Sbjct: 1050 PAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 124 bits (311), Expect = 9e-28
Identities = 149/558 (26%), Positives = 237/558 (42%), Gaps = 49/558 (8%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDI------DDGPNGQ 186
V + V D NDN+PTF Y +NE VGT++ T + D A + +
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNR 655
Query: 187 IEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQ 246
Q A L+ + L V DG + V V + RP+ +Q
Sbjct: 656 FSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQI-VVNVTDANTHRPV-FQ 713
Query: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPR 306
++ + E+ I A D+D + I Y + P+ F +
Sbjct: 714 SSHYTVNVNEDRPAGTTVVLISATDEDTG-----ENARITYFMEDSIPQ-----FRIDAD 763
Query: 307 TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQG 365
T ++ ++ + + L I A +DNG P + L I + D N+ +P F SYQG
Sbjct: 764 TGAVTTQAELDYEDQVSYTLAITA-RDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
Query: 366 YILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL--NDYTSVFTVTQT-GI 422
+ E P TS L+I A D+D + F +D F V T GI
Sbjct: 823 SVYEDVPP---------FTSVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGI 872
Query: 423 TRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYDVY 480
R L L DRE Y A D G+ + P+ V + V+D NDN P F + +DV+
Sbjct: 873 VRTLRRL---DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVF 929
Query: 481 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVG 539
V + G +V ++TA D DEG+N +I Y+I+ G + F ++ +G +T ++
Sbjct: 930 VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDR 989
Query: 540 RTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP--RFPQLMYSLEISEAMRV-GA 596
Y L +QA +AP R TV++ +L N+ P F L + + + G
Sbjct: 990 PEYVLVIQAT-SAPLVSR----ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG 1044
Query: 597 VLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 655
+ + A D + DS+TY+ E G+ + L+ +TG L L +ALD I+ + SD
Sbjct: 1045 AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Query: 656 GRPDGTSTATVNI-VVTD 672
G T+ + + ++TD
Sbjct: 1105 GVHSVTAQCALRVTIITD 1122
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 283 bits (724), Expect = 1e-75
Identities = 296/1065 (27%), Positives = 459/1065 (43%), Gaps = 117/1065 (10%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
+ V D ND +PTF+ + Y + E P GT++ T ATD D G NGQ+ Y +
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLT-----LRATDPDVGANGQVTYGGVSS 1691
Query: 195 PD---DPD-------RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 244
DPD RA + E+ T+ V V + D P T
Sbjct: 1692 ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAP-T 1750
Query: 245 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 304
+ +A L PE +P +T ++A D D + Y IL G P F +
Sbjct: 1751 FGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQ-----LQYRILDGDPSGA---FVLD 1801
Query: 305 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 363
+ E + P++R+ F L I+A +D G P L A L + +LD N+ +P F +P+Y
Sbjct: 1802 LASGEFGTMRPLDREVEPAFQLRIEA-RDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1860
Query: 364 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 423
+ E P G + L++ A D D +L + +G
Sbjct: 1861 SVEVPEDVPAGTLL---------LQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGEL 1911
Query: 424 RYLTLLQPVDREEQQTYTFSITAFDGVQE---SEPVIVNIQVMDANDNTPTFPEISYDVY 480
R L DRE+ +YTFS++A DG S V V I V D ND+ PTFP +
Sbjct: 1912 RTAAAL---DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLR 1968
Query: 481 VYTDMRPGDS-------VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 533
+ RPG S + L A D D G+N I Y + ++ TG I +A
Sbjct: 1969 L---PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARS 2025
Query: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
+ R L + A D PA S V I L + PRFP+ I E
Sbjct: 2026 PVALGPRDRVLFIVATDLGRPAR---SATGVIIVGLQGEAERGPRFPRASSEATIRENAP 2082
Query: 594 VGAVLLNLQATDREGDS--ITYAIENGDPQRVFNLSETTGILTLGKA--LDRESTDRYIL 649
G +++ +A G + ITY+I +G+ + F++ +TG +T+ A LD E + R L
Sbjct: 2083 PGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRL 2142
Query: 650 IITASDGRPDGTSTATV-NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG---QVKAT 705
++ A G G TV + + D NDNAP F L + E+ G QV+A
Sbjct: 2143 VLQAESG---GAFAFTVLTLTLQDANDNAPRF---LRPHYVAFLPESRPLEGPLLQVEAD 2196
Query: 706 DPDAGINGQVHYSLGNFN---NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHP 761
D D G GQ+ YSL LF + + G+I T L+RE+ LV++ATD
Sbjct: 2197 DLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPA 2256
Query: 762 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 821
+ TL + V+D +DN P + + V E+ G+ I Q+ DVD G + Y +
Sbjct: 2257 LVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSP 2315
Query: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
+ F++ + G +SL LD+E + + + G A +TV+V+D
Sbjct: 2316 SGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL-------AHDGPHEGRANLTVLVED 2368
Query: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
+ND P FS+ +Y+ M+ G+ I +V A D D + Y + PA
Sbjct: 2369 VNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGA--NGHISYHLAS-----PADG 2421
Query: 942 FEVEEDSGRVITRVN---LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPR 997
F V+ ++G + T V L + + +V+ A D G P ++ ATV + + + P
Sbjct: 2422 FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPS 2481
Query: 998 FTQEEYRPPPVSELATKGTMVGVISAAA----INQSIVYSIVSGNEEDTFGIN------- 1046
FT YR +L T++ + + A + ++ YSI+SGN F +
Sbjct: 2482 FTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAG 2541
Query: 1047 -------NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1099
G + + PLD+E+ T Y L V A A+ P +S+ V + + D
Sbjct: 2542 ESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA-------ADRGQPPQSSVVPVTVTVLD 2594
Query: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1144
N++PPVF + Y V ED + +L V+A+D D G + ++ +
Sbjct: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639
Score = 261 bits (668), Expect = 4e-69
Identities = 291/1066 (27%), Positives = 452/1066 (42%), Gaps = 110/1066 (10%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY----- 189
+ V D ND++P F +Y V E P GT + A D D G NG + Y
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL-----QLQAHDPDAGANGHVTYYLGAG 1897
Query: 190 -----VIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPL- 243
+++ + + A L+ + + T +V +DG GP+ + RD
Sbjct: 1898 TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHA 1957
Query: 244 -TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 302
T+ + LR P P TP + + ILY L GTP P
Sbjct: 1958 PTFPTSPLRLRLPRP-GPSFSTPTLALATLRAEDRDAGANASILYR-LAGTP---PPGTT 2012
Query: 303 MHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-ENNQSPYFTM 360
+ T E+ + PV + ++ D G P + G+ I L E + P F
Sbjct: 2013 VDSYTGEIRVARSPVALGPRDRVLFIVAT--DLGRPARSATGVIIVGLQGEAERGPRFPR 2070
Query: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN-DYTSVFTVTQ 419
S + I E+AP G I SP + A T P + L+ + F++
Sbjct: 2071 ASSEATIRENAPPGTPI------VSPRAVHA-----GGTNGPITYSILSGNEKGTFSIQP 2119
Query: 420 TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDV 479
+ + + +D E + A G + V+ + + DANDN P F Y
Sbjct: 2120 STGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLT-LTLQDANDNAPRFLRPHYVA 2178
Query: 480 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMI 537
++ ++Q+ A D D+GS G+I+Y + A+G F ++ TTG IT ++
Sbjct: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE 2238
Query: 538 VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 597
+ L + A D PA ++ TV + N + P PQ + L +SE +G+
Sbjct: 2239 IWAETRLVLMATDRGSPALVGSATLTVMVI---DTNDNRPTIPQ-PWELRVSEDALLGSE 2294
Query: 598 LLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 656
+ + D + G + Y + PQ F++ G ++L LD E DRY L + A DG
Sbjct: 2295 IAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG 2354
Query: 657 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 716
+G + TV +V DVNDNAP F L + + + + + V ATD D+G NG +
Sbjct: 2355 PHEGRANLTV--LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHIS 2412
Query: 717 YSLGNFNNLFRIT-SNGSIYT---AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 772
Y L + + F + +NG+++T V L + ++V+ A D R + T+ +++
Sbjct: 2413 YHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQL 2472
Query: 773 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG---ANVSYRIRSPEVKHFFA 829
D +D++P FT S Y V V E+LP G+T+L +EA D D A V Y I S F
Sbjct: 2473 QDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQ 2532
Query: 830 LHPFTGE--------------LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATV 875
L P E L LL LD+E+ ++ A D + V
Sbjct: 2533 LEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVA----AADRGQPPQSSVVPV 2588
Query: 876 TVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935
TV V D+ND PPVF++ Y+ V D G + V A DADP P VR+ V
Sbjct: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG--PHGLVRFTVSSGD- 2645
Query: 936 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEPVMSSSATVKILVLH--- 991
P+ +FE++E SG + L+ E +LVV A D G + T+++ ++
Sbjct: 2646 --PSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHG 2703
Query: 992 ---PGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE----E 1040
P + + E +PP GT+V + A A + YS++
Sbjct: 2704 PAFPLNLLSTSVAENQPP--------GTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGR 2755
Query: 1041 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
+ F +N+ TG + P DYE S+ L V A NL S S T V + +DE
Sbjct: 2756 EAFALNSSTGELRARVPFDYEHTESFRLLVGAADA----GNL---SASVTVSVLVTGEDE 2808
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
+ PVF + V E AR S+ V+ATD+D G ++ Y L
Sbjct: 2809 --YDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 252 bits (644), Expect = 2e-66
Identities = 282/1129 (24%), Positives = 460/1129 (40%), Gaps = 156/1129 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
V++ V+D N+++P F + + E G ++T + D GPN + Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADG----PGPNSDVRYRLL 1477
Query: 192 QYNPDDP--------------------------------DRAQNLNERRTTTTTLTVDVL 219
+ P P DR N + RR + V V
Sbjct: 1478 RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVT 1537
Query: 220 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 279
D +D P+F A+ +R PE+ P + A D D
Sbjct: 1538 DENDNAPVF------------------ASPSRVRLPEDQPPGPAALHVVARDPDL----- 1574
Query: 280 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 339
+ + Y + G F +H T LS++ P++R+ + L + A P
Sbjct: 1575 GEAARVSYRLASGG----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRS 1630
Query: 340 AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDT 399
A L + + D N+++P F Y + E+ P G TS L + A D D+
Sbjct: 1631 ATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG---------TSLLTLRATDPDVGAN 1681
Query: 400 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVI 457
++ S+ TG+ LT L+ +DREEQ+ ++ A D + V
Sbjct: 1682 GQVTYGGVSSESFSL--DPDTGV---LTTLRALDREEQEEINLTVYAQDRGSPPQLTHVT 1736
Query: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQ 516
V + V D ND+ PTF + V P ++ L A D D G+NG++ Y IL G
Sbjct: 1737 VRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDPS 1795
Query: 517 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 576
G F+++ +G ++ V + L ++A D PA + TV VL N+ +
Sbjct: 1796 GAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTV--TVLDANDHA- 1852
Query: 577 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL 633
P FP YS+E+ E + G +LL LQA D + + +TY + G F L ++G L
Sbjct: 1853 PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG-TAGAFLLEPSSGEL 1911
Query: 634 TLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 691
ALDRE Y ++A DG G ++T +V I V DVND+AP F P P L +
Sbjct: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF-PTSPLRLRLP 1970
Query: 692 E-----EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--GSIYTA---VKLN 741
+ ++A D DAG N + Y L + G I A V L
Sbjct: 1971 RPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG 2030
Query: 742 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 801
R L +VATD R +T + + + + P F ++ + EN P GT I
Sbjct: 2031 PRDR---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI 2087
Query: 802 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL--LRSLDYEAFPDQEASITF 857
+ A G N ++Y I S K F++ P TG +++ LD+E P +
Sbjct: 2088 VSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSP--RLRLVL 2144
Query: 858 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917
E+ + +T+ ++D ND P F + Y + P+ V A+D D
Sbjct: 2145 QAESGGAF-----AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199
Query: 918 PPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 976
++ Y + Q PA +F V+ +G + T L+ E +LV++A D G
Sbjct: 2200 QGS--GGQISYSLAASQ---PARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGS 2254
Query: 977 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV--YSI 1034
P + SAT+ ++V+ + R T + VSE A G+ + ++ ++ V Y +
Sbjct: 2255 PALVGSATLTVMVIDTND-NRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVL 2313
Query: 1035 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1094
+D F + G + + GPLD+E Y L++ A A +
Sbjct: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----------GPHEGRANLT 2363
Query: 1095 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1154
+ ++D N++ P F + Y + E +++L V ATD+D+G ++Y L P
Sbjct: 2364 VLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP----- 2418
Query: 1155 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1203
+GF V+ G + F ++ T G SG DV++
Sbjct: 2419 ADGFSVDPNNGTL---------------FTIVGTVALGHDGSGAVDVVL 2452
Score = 250 bits (639), Expect = 8e-66
Identities = 223/768 (29%), Positives = 350/768 (45%), Gaps = 48/768 (6%)
Query: 426 LTLLQPVDREEQQTYTFSITAFDGVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L + +DRE + Y + A+DG ++++ ++D ND+ P F + Y V
Sbjct: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266
Query: 484 DMRPGDSVIQLTAVDADEGSNGEITYEI---LVGAQGDFIINKTTGLITIAPGVEMIVGR 540
+ PG V+Q+ A DAD G NG +TYEI G F I+ TGL+ + ++ R
Sbjct: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326
Query: 541 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS-PPRFPQLMYSLEISEAMRVGAVLL 599
+ L VQA D E ++ TV++ N S F S ++SEA G ++
Sbjct: 327 VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386
Query: 600 NLQATD-REGD--SITYAIENGDPQRVFNLSETTGILTL---GKALDRESTDRYILIITA 653
+ +D +GD + ++E G+ F LS ++ L + LDRE D Y L +TA
Sbjct: 387 RISVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTA 444
Query: 654 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGI 711
+D G P + A + VTDVNDNAP FD L R + E +FV +V A DPD G
Sbjct: 445 TDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504
Query: 712 NGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 768
NGQV YSL G + F I ++G I TA L+ E+ +L+VVATDG + P S+ T+
Sbjct: 505 NGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564
Query: 769 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRS---PE 823
++ + D++DN P F + Y + E GT LQ+ A D D G +SY + +
Sbjct: 565 SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624
Query: 824 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 883
F + +G++ R+LD + P +S F V A D G + V V + D N
Sbjct: 625 GSPPFRIDAHSGDVCTTRTLDRDQGP---SSFDFTVTAVD--GGGLKSMVYVKVFLSDEN 679
Query: 884 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 943
D PP F R Y ++ + GT + + A D D R+ Y + P +F
Sbjct: 680 DNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS--HGRLSYHILAGNSP---PLFT 734
Query: 944 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1003
++E SG + L ++ +L + A D G SA V I ++ P ++
Sbjct: 735 LDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQ 794
Query: 1004 RPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1060
V E GT VG++ A + S+ G+ F ++ ++G++ PLD
Sbjct: 795 YVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854
Query: 1061 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1120
E VL ++ V A VP A+V + + D N++ P F + +
Sbjct: 855 EL-LGPVLELE------VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNT 907
Query: 1121 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1168
T + ++A D D+G S + + L + G F V+ TG ++
Sbjct: 908 APGTPIYTLRALDPDSGVNSRVTFTL----LAGGGGAFTVDPTTGHVR 951
Score = 245 bits (625), Expect = 3e-64
Identities = 305/1176 (25%), Positives = 483/1176 (41%), Gaps = 132/1176 (11%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
+T R LDR+ I+ V + + VR+ V D ND++PTF V
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761
Query: 158 E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRA-------------QN 203
E P T+ A+D D G NGQ++Y I DP A +
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL--DGDPSGAFVLDLASGEFGTMRP 1812
Query: 204 LNERRTTTTTLTVDVLDGDD--LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 261
L+ L ++ DG L L V V + D P + + PE++
Sbjct: 1813 LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAP-AFPVPAYSVEVPEDVPAG 1871
Query: 262 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 321
+ +QA D D + Y + GT F + P + EL ++R+
Sbjct: 1872 TLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA----FLLEPSSGELRTAAALDREQC 1922
Query: 322 QKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 380
+ + A + PL + I + D N+ +P F + + P +T + +
Sbjct: 1923 PSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
Query: 381 LNLTSPLRIVALDKDIEDTKD--------PELHLFLNDYTSVFTVTQTGITRYLTLLQPV 432
L + LR A D+D P ++ YT V ++ + L P
Sbjct: 1983 L---ATLR--AEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVA-----LGPR 2032
Query: 433 DREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 492
DR T S ++ + + + P FP S + + + PG ++
Sbjct: 2033 DR----VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
Query: 493 QLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITI--APGVEMIVGRTYALTVQAA 549
AV A G+NG ITY IL G + G F I +TG IT+ A G++ V L +QA
Sbjct: 2089 SPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147
Query: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-- 607
A TV L N + PRF + Y + E+ + LL ++A D +
Sbjct: 2148 SGGAFA------FTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQG 2201
Query: 608 -GDSITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTA 664
G I+Y++ P R +F++ TTG +T LDRE L++ A+D G P +A
Sbjct: 2202 SGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSA 2261
Query: 665 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG---------INGQ 714
T+ ++V D NDN P P L V E+ + + QV D D+G Q
Sbjct: 2262 TLTVMVIDTNDNRPTIPQ--PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQ 2319
Query: 715 VHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 774
+S+G + +T L+ E D Y+L ++A DG P L + V D
Sbjct: 2320 DPFSVGRYGGRVSLTG--------PLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVED 2368
Query: 775 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 832
++DN+P F+ S Y V++ E+ P G+ IL + A D D GAN +SY + SP F++ P
Sbjct: 2369 VNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA--DGFSVDP 2426
Query: 833 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKR 892
G L + D ++ ++EA D ATV V ++D ND+ P F+
Sbjct: 2427 NNGTLFTIVGT-VALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLS 2485
Query: 893 IYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ----FPYPASIFEVEEDS 948
Y+ V D G+ + T+ A DAD A+ V Y + F + E E +
Sbjct: 2486 HYRVAVTEDLPPGSTLLTLEATDADGSRSHAA-VDYSIISGNWGRVFQLEPRLAEAGESA 2544
Query: 949 GR-------VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPR-FTQ 1000
G ++ L+ E T + L V A D G+P SS V + VL + P FT+
Sbjct: 2545 GPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTR 2604
Query: 1001 EEYRPPPVSELATKGTMVGVISAAAI---NQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1057
YR + ++ V ++ A + + +++ SG+ F ++ +G + +
Sbjct: 2605 ASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHA 2664
Query: 1058 LDYETRTSYVLRVQADSLEVVLANLRVPSKSN--TAKVYIEIQDENNHPPVFQKKFYIGG 1115
LD ET+ + L VQA P+ ++ A V IE+QD N+H P F
Sbjct: 2665 LDCETQARHQLVVQAAD----------PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTS 2714
Query: 1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLI-IPPIKEGKEGFVVETYTGLIKTAMLFH 1174
V+E+ T V + A D D G + + Y L+ P EG+E F + + TG ++ + F
Sbjct: 2715 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFD 2774
Query: 1175 NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
F+ V A D S VLV+ ++ D
Sbjct: 2775 YEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD 2810
Score = 242 bits (618), Expect = 2e-63
Identities = 321/1281 (25%), Positives = 511/1281 (39%), Gaps = 143/1281 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + ++D NDN P F+ Y A++ E T GT ATD D GP G + Y +
Sbjct: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL-----QVTATDADSGPFGLLSYSLG 618
Query: 193 Y----NPDDPDRAQNLNERRTTTTTL-----------TVDVLDGDDLGPMFLPCVLVPNT 237
+ P R + TT TL TV +DG L M V + +
Sbjct: 619 AGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
Query: 238 RDCRPLTYQAAIPELRTPEELNPIIV--TPPIQAIDQDRNIQPPSDRPGIL-YSILVGTP 294
D P Y P E I +PP A+ + R P G L Y IL G
Sbjct: 679 NDNPPQFY---------PREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNS 729
Query: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 354
P F + ++ L++ P+ R + L I AE G A + I I+
Sbjct: 730 ---PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 786
Query: 355 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 414
P F Y + E G ++ P R+ + L L D +
Sbjct: 787 PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVT----------LSLSGGDPRGL 836
Query: 415 FTVTQTGITRYLTLLQPVDREEQ-QTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTF 472
F++ ++ L L+P+DRE + A GV + V V + + D NDN+P F
Sbjct: 837 FSLD--AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAF 894
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 532
P V + + PG + L A+D D G N +T+ +L G G F ++ TTG + +
Sbjct: 895 PAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMR 954
Query: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
+ G + L ++A D P + V ++ + + PRF Y +++
Sbjct: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLA-PRFNSPTYRVDLPSGT 1013
Query: 593 RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 652
G +L +QA +G ITY + F L +G L + ALDRE+ + YIL +
Sbjct: 1014 TAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVM 1073
Query: 653 ASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDP 707
A G T TATV + + + N+++P P L+V E + VG+V ATD
Sbjct: 1074 AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSED-PTFLAVAENQPPGTSVGRVFATDR 1132
Query: 708 DAGINGQVHYSLGNF---NNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRH 763
D+G NG++ YSL + FRI G + T L+RE + Y+L+V DG PR
Sbjct: 1133 DSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRS 1192
Query: 764 STLTLAIKVLDIDDNSPVFTNST------YTVLVEENLPAGTTILQIEAKDVDLGAN--V 815
+T T+ + VLD++DNSP F ++ + V + +P GT + ++AKD D G N +
Sbjct: 1193 TTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI 1252
Query: 816 SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATV 875
Y + P F+LHP +GEL L P +++ A D PP A++
Sbjct: 1253 LYTLTGPG-SELFSLHPHSGELLTAAPLIRAERPHYVLTLS----AHD--QGSPPRSASL 1305
Query: 876 TVIVK-----DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL--------P 922
++V+ + + PP ++R P A +T AE P L P
Sbjct: 1306 QLLVQVLPSARLAEPPPDLAER------DPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP 1359
Query: 923 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 982
A V P F ++ SGR+ L+ E ++ + V + +
Sbjct: 1360 AGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARL 1419
Query: 983 ATVKILVLHPGE-IPRFTQEEY------RPPPVSELATKGTMVGVISAAAINQSIVYSIV 1035
V++ V E P F ++ P P + L T N + Y ++
Sbjct: 1420 LRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT--FRASDADGPGPNSDVRYRLL 1477
Query: 1036 SGNEE-DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1094
++ TG + LD ET + +L V+A + R S A+V+
Sbjct: 1478 RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVS--ARVF 1535
Query: 1095 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1154
+ DEN++ PVF + + ED + L V A D D G + ++YRL G
Sbjct: 1536 --VTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVARDPDLGEAARVSYRL----ASGG 1588
Query: 1155 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1214
F + + TG + +R+ V+A+D S + VSV +
Sbjct: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVAD------- 1641
Query: 1215 VSNVPPTLVEKKIEDL--------TEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDY 1266
V++ PT +++ L T +L + GA V G ++FSL+
Sbjct: 1642 VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV--SSESFSLDPD 1699
Query: 1267 TKCDLTVYAIDPQTNRAI-------DRN---ELFKFLDGKLLDINKDFQPYYGEGGRILE 1316
T T+ A+D + I DR +L ++ D P +G LE
Sbjct: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLE 1759
Query: 1317 I---RTPEAVTSIKKRGESLG 1334
+ + P+ +T ++ +G
Sbjct: 1760 VPEGQDPQTLTMLRASDPDVG 1780
Score = 239 bits (611), Expect = 1e-62
Identities = 309/1229 (25%), Positives = 495/1229 (40%), Gaps = 137/1229 (11%)
Query: 46 IDEESRNGTILVDNM--LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVL 103
IDEE GT++ D L GTA I V + +D ++ T RVL
Sbjct: 51 IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV---RTARVL 107
Query: 104 DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
DR+ V G + EV + V D ND++P F V E T G
Sbjct: 108 DREQRDRYRFTAVTPD------GATV--EVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
Query: 164 T----------------TIFTGFSGDNGAT----DIDDGPNGQI--EYVIQYNPDDPDRA 201
T T SGD + GP+G E V+ D +R+
Sbjct: 160 TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 219
Query: 202 QNL---------NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
+ + R L V +LD +D P F Y A + E
Sbjct: 220 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF------------NQSRYHAVVSES 267
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE-DYPRFFHMHPRTAELS 311
P +P++ + A D D + + Y I E D P F + T L
Sbjct: 268 LAPG--SPVL---QVFASDADAGVNG-----AVTYEINRRQSEGDGP--FSIDAHTGLLQ 315
Query: 312 LLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG----YI 367
L P++ + + +LV++A HP A + + + D N+ P T+ +
Sbjct: 316 LERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQV 375
Query: 368 LESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYL 426
E+AP G ++ RI D D D +++ L F + TQ + +
Sbjct: 376 SEAAPPGQLVA---------RISVSDPD--DGDFAHVNVSLEGGEGHFALSTQDSVIYLV 424
Query: 427 TLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
+ + +DREE+ Y +TA D +E V + V D NDN P F Y
Sbjct: 425 CVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLP 483
Query: 484 DMR-PGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRT 541
++ PG V+++TA D D+G+NG++TY + GA F I+ T+G+IT A ++ +
Sbjct: 484 EVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ 543
Query: 542 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 601
L V A D P ++ +V ++ + N + P+F + Y+ + E + G L +
Sbjct: 544 PQLIVVATDGGLPPLASSATVSVALQDV---NDNEPQFQRTFYNASLPEGTQPGTCFLQV 600
Query: 602 QATDREGDS---ITYAI-----ENGDPQRVFNLSETTGILTLGKALDRES-TDRYILIIT 652
ATD + ++Y++ +G P F + +G + + LDR+ + +T
Sbjct: 601 TATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTTRTLDRDQGPSSFDFTVT 658
Query: 653 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
A DG S V + ++D NDN P F P + V +++A DPD G +
Sbjct: 659 AVDGG-GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSH 717
Query: 713 GQVHYSL--GNFNNLFRITSNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 769
G++ Y + GN LF + + T A L R +L + A DG + +
Sbjct: 718 GRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVD 777
Query: 770 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG-ANVSYRIRSPEVKHFF 828
I ++ P+F Y V E++ GT++ ++A + A V+ + + + F
Sbjct: 778 ISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLF 837
Query: 829 ALHPFTGELSLLRSLDYEAF-PDQEASITFLVEAFDIYGTMPPG--IATVTVIVKDMNDY 885
+L +G L LR LD E P E + +PP +A V V++ D+ND
Sbjct: 838 SLDAVSGLLQTLRPLDRELLGPVLELEVR-------AGSGVPPAFAVARVRVLLDDVNDN 890
Query: 886 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 945
P F ++ P+ GTPI T+ A D D S V RV F V+
Sbjct: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD------SGVNSRVTFTLLAGGGGAFTVD 944
Query: 946 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE---IPRFTQEE 1002
+G V L +L + A D G P +S ++++V G PRF
Sbjct: 945 PTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPT 1004
Query: 1003 YRPPPVSELATKGTMVGVISAAAINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1061
YR S T GT V + A A + I Y + + FG+ +G ++V LD E
Sbjct: 1005 YRVDLPSG-TTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDRE 1063
Query: 1062 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1121
+ Y+L+V A V + + ++ TA V + I ++N H P + V+E+
Sbjct: 1064 AQELYILKVMA----VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQP 1119
Query: 1122 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYF 1181
TSV RV ATD+D+G + Y L + E + F + TG + T ++S +
Sbjct: 1120 PGTSVGRVFATDRDSGPNGRLTYSL--QQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSY 1177
Query: 1182 KFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
+ V D S V V+V++ D
Sbjct: 1178 QLLVQVQDGGSPPRSTTGTVHVAVLDLND 1206
Score = 239 bits (611), Expect = 1e-62
Identities = 251/922 (27%), Positives = 408/922 (44%), Gaps = 104/922 (11%)
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
F +HP+T E++ L+ ++R+ + L+++ + P +H+ +LD N+ SP F
Sbjct: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
Query: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
S +A G I + + L KDP+ + T ++T+T
Sbjct: 1214 AS------GAAGGGLPIQVPDRVPPGTLVTTLQ-----AKDPDEG---ENGTILYTLTGP 1259
Query: 421 GITRY--------LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVM--------- 463
G + L P+ R E+ Y +++A D Q S P ++Q++
Sbjct: 1260 GSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHD--QGSPPRSASLQLLVQVLPSARL 1317
Query: 464 -----DANDNTPTFP-EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-- 515
D + P P + V +RPG + + A + G +TY ++ GA
Sbjct: 1318 AEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYTLVGGADP 1375
Query: 516 QGDFIINKTTGLITIAPGVEMIVGRTY-ALTVQAADNAPPAERRNSICTVYIEVLPPNNQ 574
+G F ++ +G + +A ++ G + ALTV+A R + V ++V N+
Sbjct: 1376 EGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGAR---LLRVQVQV-QDENE 1431
Query: 575 SPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG----DSITYAIENGDPQ-RVFNLSET 629
P F + +L + E GA L +A+D +G + Y + +P L
Sbjct: 1432 HAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDAR 1491
Query: 630 TGILTLGKALDRESTDRYILIITASDGRPDGTST-----ATVNIVVTDVNDNAPVFDPYL 684
TG L+ + LDRE+T +L++ A+D RP S + + VTD NDNAPVF
Sbjct: 1492 TGALSAPRGLDRETTPALLLLVEATD-RPANASRRRAARVSARVFVTDENDNAPVFAS-- 1548
Query: 685 PRNLSVVEEEANAFVG-QVKATDPDAGINGQVHYSLGNFNN-LFRI-TSNGSIYTAVKLN 741
P + + E++ V A DPD G +V Y L + + FR+ +S G++ L+
Sbjct: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLD 1608
Query: 742 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 801
RE R + L VVA+D PR +T L + V D++D +P F Y+VL+ EN P GT++
Sbjct: 1609 REQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSL 1668
Query: 802 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
L + A D D+GAN V+Y S E F+L P TG L+ LR+LD E ++ I V
Sbjct: 1669 LTLRATDPDVGANGQVTYGGVSSE---SFSLDPDTGVLTTLRALDRE----EQEEINLTV 1721
Query: 860 EAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917
A D PP + TV V V+D ND+ P F + + P+ +T + A D D
Sbjct: 1722 YAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGS-AHLSLEVPEGQDPQTLTMLRASDPD 1778
Query: 918 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 977
+++YR+ D P+ F ++ SG T L+ E F+L + A D G+P
Sbjct: 1779 VGA--NGQLQYRILDGD---PSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
Query: 978 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVY 1032
+S++ + + VL + P F Y V E GT++ + A A N + Y
Sbjct: 1834 ALSATLLLTVTVLDANDHAPAFPVPAY-SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892
Query: 1033 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1092
+ +G F + +G + LD E SY V A + S T
Sbjct: 1893 YLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSA------VDGAAAGPLSTTVS 1945
Query: 1093 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFT----SVLRVKATDKDTGNYSVMAYRLII 1148
V I ++D N+H P F + F+ ++ ++A D+D G + + YRL
Sbjct: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAG 2005
Query: 1149 PPIKEGKEGFVVETYTGLIKTA 1170
P G V++YTG I+ A
Sbjct: 2006 TP----PPGTTVDSYTGEIRVA 2023
Score = 217 bits (553), Expect = 8e-56
Identities = 282/1078 (26%), Positives = 447/1078 (41%), Gaps = 128/1078 (11%)
Query: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
PA V + E+ GT+L+ AG +V Y++ L S+
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGA---------NGHVTYYLGAGTAGAFLLEPSS 1908
Query: 100 GRV-----LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
G + LDR+ P S+ + T + V I VRD ND++PTF
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLR 1966
Query: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLN-ERRTTTT 212
+ P +T + A D D G N I Y + P + E R +
Sbjct: 1967 LRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARS 2025
Query: 213 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV--------- 263
+ + D L V R R T I L+ E P
Sbjct: 2026 PVALGPRD------RVLFIVATDLGRPARSAT-GVIIVGLQGEAERGPRFPRASSEATIR 2078
Query: 264 --TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 321
PP I R + I YSIL G + F + P T +++ DF
Sbjct: 2079 ENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGT---FSIQPSTGAITVRSAEGLDFE 2135
Query: 322 --QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISD 379
+ LV++AE AF L + + D N+ +P F P Y ++ ES P
Sbjct: 2136 VSPRLRLVLQAESGGAF---AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRP------- 2185
Query: 380 SLNLTSPLRIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREE 436
L PL V D D++ ++ L +F V T T +T +DRE
Sbjct: 2186 ---LEGPLLQVEAD-DLDQGSGGQISYSLAASQPARGLFHVDPT--TGTITTTAILDREI 2239
Query: 437 QQTYTFSITAFDGVQESEPVIVN-----IQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 491
+ A D P +V + V+D NDN PT P+ +++ V D G +
Sbjct: 2240 WAETRLVLMATD---RGSPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEI 2295
Query: 492 IQLTAVDADEGSNGEITYEILV--GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
Q+T D D +G + + +L G Q F + + G +++ ++ Y L + A
Sbjct: 2296 AQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAH 2352
Query: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD 609
D P E R ++ TV +E + N + P F Q +Y + + E G+ +L++ ATDR+
Sbjct: 2353 DG--PHEGRANL-TVLVEDV---NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
Query: 610 S---ITYAIENGDPQRVFNLSETTGIL--TLGK-ALDRESTDRYILIITASD-GRPDGTS 662
+ I+Y + + P F++ G L +G AL + + +++ A D G P +
Sbjct: 2407 ANGHISYHLAS--PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAA 2464
Query: 663 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSL-- 719
ATV++ + D ND+AP F R + + + ++ATD D + V YS+
Sbjct: 2465 RATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIIS 2524
Query: 720 GNFNNLFRITSN---------------GSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
GN+ +F++ G + L+ E Y L V A D P+ S
Sbjct: 2525 GNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSS 2584
Query: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 822
+ + + VLD++DN PVFT ++Y V V E+ P G +L +EA D D G + V + + S
Sbjct: 2585 VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSG 2644
Query: 823 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 882
+ F L +G L L +LD E +A +V+A D G +A VT+ V+D+
Sbjct: 2645 DPSGLFELDESSGTLRLAHALDCET----QARHQLVVQAADPAGAHF-ALAPVTIEVQDV 2699
Query: 883 NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV-QFPYPASI 941
ND+ P F + VA + GT +TT++A D D R+RY + + P
Sbjct: 2700 NDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF--GRLRYSLLEAGPGPEGREA 2757
Query: 942 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQ 1000
F + +G + RV + E T F+L+V A D G +S+S TV +LV E P F
Sbjct: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLA 2815
Query: 1001 EEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1054
+ V E A +G +G + A + ++YS+ + + FGIN TG +Y+
Sbjct: 2816 PAFHFQ-VPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYL 2870
Score = 62.0 bits (149), Expect = 5e-09
Identities = 97/444 (21%), Positives = 165/444 (37%), Gaps = 76/444 (17%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 189
V + ++D+ND++P+F Y V E P G+T+ T ATD D + ++Y
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522
Query: 190 -------VIQYNPDDPDRAQN----------------LNERRTTTTTLTVDVLD-GDDLG 225
V Q P + ++ L+ T LTV D G
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQ 2582
Query: 226 PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGI 285
+P + + P + A + PE+ ++A D D P +
Sbjct: 2583 SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDAD-----PGPHGLV 2637
Query: 286 LYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 345
+++ G P F + + L L ++ + + LV++A G A A +
Sbjct: 2638 RFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVT 2693
Query: 346 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD---------- 395
IE+ D N+ P F + + E+ P G ++ + A+D D
Sbjct: 2694 IEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT---------LHAIDGDAGAFGRLRYS 2744
Query: 396 -IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 454
+E PE F + + T L P D E +++ + A D S
Sbjct: 2745 LLEAGPGPEGR-------EAFALNSS--TGELRARVPFDYEHTESFRLLVGAADAGNLSA 2795
Query: 455 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 514
V V++ V ++ P F ++ V R G S+ + A D D G++G + Y L
Sbjct: 2796 SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS-LAT 2854
Query: 515 AQGDFIINKTTGLITI-----APG 533
+ F IN+TTG + + APG
Sbjct: 2855 SSPYFGINQTTGALYLRVDSRAPG 2878
Score = 52.0 bits (123), Expect = 6e-06
Identities = 68/290 (23%), Positives = 106/290 (36%), Gaps = 45/290 (15%)
Query: 944 VEEDSGRVITRVNLNEEPTTIFKLVVVAFD--------------DGEPVMSSSATVKILV 989
++E SG V T L+ E ++ V D D P + +
Sbjct: 94 IDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVP 153
Query: 990 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1049
H R+ E R L T+G Y++ +TF +
Sbjct: 154 EHTAFGTRYPLEPARDADAGRLGTQG----------------YALSGDGAGETFRLETRP 197
Query: 1050 GV-------IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
G + V G LD E R+ Y+L+++A + P + A + + + D N+
Sbjct: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEA-------YDGGSPPRRAQALLDVTLLDIND 250
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
H P F + Y VSE + VL+V A+D D G + Y I EG F ++
Sbjct: 251 HAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE-INRRQSEGDGPFSIDA 309
Query: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1212
+TGL++ +R + V A D G A V V V + D Q
Sbjct: 310 HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQ 359
Score = 36.6 bits (83), Expect = 0.24
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 6/73 (8%)
Query: 1338 GALLALAFIIILCCIPAILVVLVSYRQRQAECTKTARIQAALPAAKPAVPAPAPVAAPPP 1397
GA+ A ++++ + A+++ LV R R+AE QAA P A ++
Sbjct: 2939 GAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAA-PLASDSLQ-----KLGRE 2992
Query: 1398 PPPPPPGAHLYEE 1410
PP PPP HLY +
Sbjct: 2993 PPSPPPSEHLYHQ 3005
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 282 bits (722), Expect = 2e-75
Identities = 340/1260 (26%), Positives = 544/1260 (43%), Gaps = 156/1260 (12%)
Query: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
Query: 189 YVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 248
Y + + N TTT+ D P + V+ + + PL QA
Sbjct: 880 YSVSSEDSSDHFKIDANNGEIRTTTIL-----SYDYRPSYRMSVIATD-QGVPPLQGQAV 933
Query: 249 IPELRTPEELNPIIVTPPIQAIDQDRNIQP--------PSDR-----PGILYSILVGTPE 295
+ P I++ I+ + N++P SD G L+ +V +
Sbjct: 934 VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVA--D 991
Query: 296 DYPRFFHMHPRTAELSLLEPVNRD--FHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
D F + T +L L + ++ + H F VI + L + L I++ D+N+
Sbjct: 992 DKDGHFEIDSSTGDLFLSKELDYETTSHYLF-RVITTDHSKNLSLSSTVFLSIDVEDQND 1050
Query: 354 QSPYFTMPSYQGYILESAPVGATI-------SDSLNLTSPLRIVALDKDIEDTKDPELHL 406
SP F + E+ P+G + D L S ++ E H
Sbjct: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYI-----------ESH- 1098
Query: 407 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPVIVNIQ 461
N T+ F + + T L + +DRE T ++TA D + + I
Sbjct: 1099 --NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
Query: 462 VMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DF 519
++D ND+ PTF IS+ + +V D+ G V +TA D DEG NG++TY IL G + F
Sbjct: 1155 ILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTF 1212
Query: 520 IINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRF 579
++++++GL+T ++ + + LTV A D+ PA +S T+ + VL N+++P F
Sbjct: 1213 MLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA--LSSSQTLTVTVLDVNDEAPV-F 1269
Query: 580 PQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLG 636
Q +Y + E G + ++A DR+ + + I G +F ++ TG +
Sbjct: 1270 KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTT 1329
Query: 637 KALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
LDRE + + L + DG P +ST T+ V D ND+AP F ++ V+E +
Sbjct: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEF-IVSSYDIEVLENQE 1388
Query: 696 NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVV 752
V V A+D DAG N V Y + GN + F I +G + T L+RE + LV+
Sbjct: 1389 PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVI 1448
Query: 753 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 812
+ +D PR S + L ++VLD +D+SP F Y V E+ GT +L + A D D G
Sbjct: 1449 LCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEG 1508
Query: 813 AN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMP 869
N + + E F + P +G L +LD EA + TF A D I G+
Sbjct: 1509 LNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA----RSQHTFSAVARDCSIQGSRS 1564
Query: 870 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 929
+ + V V D+ND PV + + ++P++ V A+D D P V +
Sbjct: 1565 TTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLG--PNGTVVFS 1621
Query: 930 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 989
+ Q S+F +++ +G + + N + E I+ L + D G P + T +LV
Sbjct: 1622 FAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIP---ARTTTGLLV 1672
Query: 990 LH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTF 1043
+H GE + F+ Y+ V+E GT + + A A I S+ YSI SGNE+
Sbjct: 1673 IHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVL 1731
Query: 1044 GINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
+ + +G + V P LD+E R L V A+S KV + IQDEN
Sbjct: 1732 SLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES----------SGHRAYCKVAVLIQDEN 1781
Query: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
++ P F++ Y VSE V++V ATD D+G ++ Y ++ +E F ++
Sbjct: 1782 DNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSIL---SGNQEEAFQID 1838
Query: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1221
+G+I T + S + V ATD KG+ ++ V V D I N P
Sbjct: 1839 ALSGVITTKAILDYELTSSYSLIVQATD---KGMPRLSNTTVIKVQVTD---INDNAPAF 1892
Query: 1222 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTN 1281
L + +E ++ +PG V S+ AF + + K +P T
Sbjct: 1893 LPSEAVE--------ITEDSLPGVIVTHVSVHDVDLNSAF-IFSFAK------ESNPGTK 1937
Query: 1282 RAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALL 1341
AID+N L L DF+ E+ E + I +S+ YTEGAL+
Sbjct: 1938 FAIDQNTGVVVLVKTL-----DFE----------EMTEYELLIQI---SDSVHYTEGALV 1979
Score = 266 bits (681), Expect = 1e-70
Identities = 300/1128 (26%), Positives = 480/1128 (42%), Gaps = 127/1128 (11%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI--- 191
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
Query: 192 ------QYNPDDPDRAQN--LNERRTTTTTLTVDVLDGD--DLGPMFLPCVLVPNTRDCR 241
+ N D + L+ TL V V DG L V + D
Sbjct: 1312 ASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHA 1371
Query: 242 P----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
P +Y + E + PE + ++ A D D + + Y I+ G ++
Sbjct: 1372 PEFIVSSYDIEVLENQEPEVVYTVL------ASDMDAG-----NNRAVEYHIIDGNTDEC 1420
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
F ++ + ELS ++R+ F LVI P + L + +LD N+ SP
Sbjct: 1421 ---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-VFT 416
F YQ + E A VG + L + A+DKD + + + FL D S FT
Sbjct: 1478 FPTLYYQSSVREDAEVGTVV---------LVLSAVDKD--EGLNGQTEYFLTDEASGAFT 1526
Query: 417 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ESEPVIVNIQVMDANDNTPTFP 473
+ T L +DRE + +TFS A D +Q S VI+ + V D NDN P
Sbjct: 1527 IDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
Query: 474 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIA-- 531
+ +DV++ + + + + A D D G NG + + Q F I+K TG I
Sbjct: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-AETQSMFSIDKYTGEIQFQQN 1643
Query: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
P E L ++ D PA + +++E F +Y ++E
Sbjct: 1644 PSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME----GEDVKISFSHHLYKGLVTEN 1696
Query: 592 MRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSETTGILTLG--KALDRESTDRY 647
G ++ ++A D DS+ Y+I +G+ V +L +G LT+ K LD E +
Sbjct: 1697 CEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEV 1756
Query: 648 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 707
LI+ A + V +++ D NDN+P F+ + + + NA V QV ATD
Sbjct: 1757 QLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
Query: 708 DAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
D+G+NG + YS+ GN F+I + +G I T L+ E+ Y L+V ATD + +
Sbjct: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
Query: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR---S 821
T + ++V DI+DN+P F S + E++LP G + + DVDL + + +
Sbjct: 1875 TTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVDLNSAFIFSFAKESN 1933
Query: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
P K FA+ TG + L+++LD+E + E I G + V V D
Sbjct: 1934 PGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGAL-------VVRVLD 1984
Query: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
+ND PPVFS+ Y+ V G + T+ A D + + YR+ +
Sbjct: 1985 VNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN----ENISYRILS-----SSKE 2035
Query: 942 FEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PR 997
F ++ +G + T + L+ TT F +V A D G P + + V+I + P
Sbjct: 2036 FSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPDLRALTLVEIGIEDMNNYAPE 2093
Query: 998 FTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVYSIVSGNEEDTFGINNI---- 1048
FT + Y +SE A G+ + S N + YSI+SGN ++ F +
Sbjct: 2094 FTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHS 2152
Query: 1049 ------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
G + + LD E S+ L ++ ++ P S+TA + I++ D N+
Sbjct: 2153 EYPYKQVGYLVLLHSLDREASASH-------ELVILASDSGCPPLSSTAVISIQVLDVND 2205
Query: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
+PP F Y V E + + + V A D+DTG+++ + Y +I K F +E
Sbjct: 2206 NPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNII---SGNEKGHFYLEE 2262
Query: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
TG++ + + F V A+D K S A V VSV++ D
Sbjct: 2263 NTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSVLDDND 2309
Score = 256 bits (653), Expect = 2e-67
Identities = 274/1054 (25%), Positives = 458/1054 (43%), Gaps = 107/1054 (10%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
Query: 193 -YNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT-----RDCRPLTYQ 246
+NP + T +TV LD + + + L R R LT Q
Sbjct: 1097 SHNPG----TNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Query: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNI----------QPPSDRPG-ILYSILVGTPE 295
I ++ + NP ++ P + +D + P R G + YSIL G
Sbjct: 1153 IVILDV---NDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNEN 1209
Query: 296 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQS 355
F + + L+ P++ + + L + A D L + L + +LD N+++
Sbjct: 1210 ---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1266
Query: 356 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 415
P F Y+ + E+ G ++ R+ ALD+D + + +F
Sbjct: 1267 PVFKQHLYEASVKENQNPGEFVT---------RVEALDRDSGVNSKLQFEIMPGASFELF 1317
Query: 416 TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTF 472
+ + TG T+L DRE Q+ +T + DG S + V D ND+ P F
Sbjct: 1318 EINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEF 1374
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 531
SYD+ V + P + V + A D D G+N + Y I+ G + F IN+ +G ++
Sbjct: 1375 IVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTT 1433
Query: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
++ + L + +D P R+S+ + + VL N+ S P FP L Y + E
Sbjct: 1434 RALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLDANDHS-PSFPTLYYQSSVRED 1490
Query: 592 MRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
VG V+L L A D++ + T + F + +G L LDRE+ ++
Sbjct: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTF 1550
Query: 650 IITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQV 702
A D G+ + TV + VTDVNDN PV FD +L E N V
Sbjct: 1551 SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS-----PESPTNQTTVIV 1605
Query: 703 KATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHP 761
+A D D G NG V +S ++F I G I + E + + V G P
Sbjct: 1606 RADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGI--P 1663
Query: 762 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD-LGANVSYRIR 820
+T L + ++ +D F++ Y LV EN AGT+I+ ++A D + ++ Y I
Sbjct: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIF 1723
Query: 821 SPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
S +L +G+L++ + LD+E E + L E+ + V V+
Sbjct: 1724 SGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIVLAES-----SGHRAYCKVAVL 1776
Query: 879 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 938
++D ND P F + IY+ V+ + + V+A D D GL + Y +
Sbjct: 1777 IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD-SGL-NGLIEY---SILSGNQ 1831
Query: 939 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPR 997
F+++ SG + T+ L+ E T+ + L+V A D G P +S++ +K+ V + P
Sbjct: 1832 EEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPA 1891
Query: 998 FTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDT-FGINNITGVIYV 1054
F E ++E + G +V +S +N + ++S + T F I+ TGV+ +
Sbjct: 1892 FLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVL 1949
Query: 1055 NGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1113
LD+E T Y L +Q +DS+ + + + D N++PPVF + FY
Sbjct: 1950 VKTLDFEEMTEYELLIQISDSVHY-----------TEGALVVRVLDVNDNPPVFSQDFYQ 1998
Query: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
V E + SVL + ATD ++ ++YR++
Sbjct: 1999 VTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
Score = 247 bits (630), Expect = 9e-65
Identities = 274/1131 (24%), Positives = 481/1131 (42%), Gaps = 129/1131 (11%)
Query: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQY 193
V D ND++P F SY V N+ V T+ A+D+D G N +EY +I
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHIIDG 1415
Query: 194 NPDDPDRAQNLNERRTTTTTLTVDVLDG-------DDLGPMFLPCVL-----VPNTRDCR 241
N D+ ++ +TT L + + DLG V+ V + D
Sbjct: 1416 NTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHS 1475
Query: 242 P----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
P L YQ+++ R E+ +++ + A+D+D + ++ Y + ++
Sbjct: 1476 PSFPTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLNGQTE-----YFLT----DEA 1521
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNGHPLPAFAGLHIEILDENNQS 355
F + P + L ++R+ + F V + G + + + D N+
Sbjct: 1522 SGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI-IKVYVTDVNDND 1580
Query: 356 PYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 411
P + ++ +P T +D L+L +V + + ++ Y
Sbjct: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM------FSIDKY 1634
Query: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471
T Q + Y + + +Q G+ + + M+ D +
Sbjct: 1635 TGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIPARTTTGLLVIHMEGEDVKIS 1683
Query: 472 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITI 530
F Y V + G S++ + A A + + Y I G + G + +G +T+
Sbjct: 1684 FSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
Query: 531 APG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 588
++ V L V A + + C V + + N+ SP F Q +Y +
Sbjct: 1743 KEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLIQDENDNSPC-FEQSIYQASV 1796
Query: 589 SEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 645
SE+ A ++ + ATD + I Y+I +G+ + F + +G++T LD E T
Sbjct: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
Query: 646 RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 704
Y LI+ A+D G P ++T + + VTD+NDNAP F LP + E++ V
Sbjct: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---LPSEAVEITEDSLPGVIVTHV 1913
Query: 705 TDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVH 760
+ D +N +S +N F I N + VK L+ E YEL++ +D +VH
Sbjct: 1914 SVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVH 1972
Query: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR 820
++ L ++VLD++DN PVF+ Y V V E++P G ++L + A D++ N+SYRI
Sbjct: 1973 --YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRIL 2030
Query: 821 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 880
S + F++ P G + + + D ++ FLVEA D + V + ++
Sbjct: 2031 SSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIE 2085
Query: 881 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV----DDVQFP 936
DMN+Y P F+ + Y ++ DA+ G+ + T D D + V Y + F
Sbjct: 2086 DMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR-ENTYVEYSIISGNSQNNFH 2144
Query: 937 YPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 993
F E + G ++ +L+ E + +LV++A D G P +SS+A + I VL
Sbjct: 2145 VETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVN 2204
Query: 994 EIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNI 1048
+ P F+ Y V E G+ + V+SA + I+Y+I+SGNE+ F +
Sbjct: 2205 DNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
Query: 1049 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1108
TGV+Y+ PLDYE T + L VQA E + A V++ + D+N+H P F
Sbjct: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHFSFAVVFVSVLDDNDHAPQFM 2315
Query: 1109 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP-----PIKEGKEGFVVETY 1163
+ V E+ + +++ + A D D G Y + Y ++ P + + F+++
Sbjct: 2316 FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL 2375
Query: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1214
TG I + + + V A D K D S+V +D++ I
Sbjct: 2376 TGDIHAKQILDYENGNKYCLTVQAKD--------KGDATASLVVWVDIEGI 2418
Score = 244 bits (624), Expect = 4e-64
Identities = 291/1144 (25%), Positives = 474/1144 (41%), Gaps = 138/1144 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
Query: 192 ---QYNPDDPDRAQNL---------NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 239
Q DRA + E+R T TL + + + V++
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREH 579
Query: 240 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 299
T++ + ++ E L+P +T +Q Q + P + YS+ P
Sbjct: 580 SPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAHPLGPQRAASPLRYSL---EPSVDSA 632
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPYF 358
F + P T + L + + Q ++ + A ++G + + + DEN+ SP F
Sbjct: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 692
Query: 359 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT 418
+ +E +PV + +I A+D D K+ +L FL F +
Sbjct: 693 -LHDVLFLKVEESPVPQGVIG--------KITAIDMD--SGKNGQLLYFLLSDGKFFKMN 741
Query: 419 -QTGITRYLTLLQPVD-------------REEQQTY------------------------ 440
TG + ++ D +E Q +
Sbjct: 742 PNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREH 801
Query: 441 ------TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 494
T +T + + V + V D NDN P FP+ ++ + G V L
Sbjct: 802 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 861
Query: 495 T----AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
A D DEG+N E+TY + D F I+ G I + +Y ++V A
Sbjct: 862 VTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIAT 921
Query: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD---- 605
D P + ++ V I+V+ P ++ Q + L I E ++ ++ ++++D
Sbjct: 922 DQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQ 978
Query: 606 REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 665
+ ++I D F + +TG L L K LD E+T Y+ + +D + + ++T
Sbjct: 979 HYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST 1038
Query: 666 V--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV----KATDPDAG-INGQVHYS 718
V +I V D ND++P F L V+ E N +G + A D D +N ++ Y
Sbjct: 1039 VFLSIDVEDQNDHSPSFQD----ELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYY 1094
Query: 719 LGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH---PRHSTLTLAIK 771
+ + N N F I S G++ T +L+RE L V A+D AV+ R +LT I
Sbjct: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV 1154
Query: 772 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 829
+LD++D++P F S V+E++ G+ + I A D D G N V+Y I S F
Sbjct: 1155 ILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFM 1213
Query: 830 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 889
L +G L+ LDYE + V A D T+TV V D+ND PVF
Sbjct: 1214 LDESSGLLTTTCPLDYE----MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF 1269
Query: 890 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDS 948
+ +Y+ V + G +T V A D D S V ++ P + +FE+ D+
Sbjct: 1270 KQHLYEASVKENQNPGEFVTRVEALDRD------SGVNSKLQFEIMPGASFELFEINSDT 1323
Query: 949 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPP 1007
G V+T L+ E +F L V+ D G P +SS+ T+ V + P F Y
Sbjct: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
Query: 1008 V--SELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1065
+ E T++ A N+++ Y I+ GN ++ F IN ++G + LD E ++
Sbjct: 1384 LENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISN 1443
Query: 1066 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1125
+ +L ++ ++L P +S+ + + + D N+H P F +Y V EDA + T
Sbjct: 1444 F-------TLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTV 1496
Query: 1126 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1185
VL + A DKD G Y L E F ++ +G +KT+ RS F
Sbjct: 1497 VLVLSAVDKDEGLNGQTEYFL----TDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSA 1552
Query: 1186 IATD 1189
+A D
Sbjct: 1553 VARD 1556
Score = 217 bits (553), Expect = 8e-56
Identities = 258/1095 (23%), Positives = 462/1095 (42%), Gaps = 129/1095 (11%)
Query: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVT 1178
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTT--------- 212
VG+ + A D D+G NG++ Y I ++ + + TTT
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKT 1233
Query: 213 --------------------TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
TLTV VLD +D P+F + Y+A++ E
Sbjct: 1234 QHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF------------KQHLYEASVKEN 1281
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
+ P E ++A+D+D + + + I+ G + F ++ T E+
Sbjct: 1282 QNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEINSDTGEVVT 1328
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESA 371
++R+ + F L + +D G P L + + + DEN+ +P F + SY +LE+
Sbjct: 1329 TTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
Query: 372 PVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
+ ++A D D + + E H+ + FT+ + ++ L+ +
Sbjct: 1388 EPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MSGELSTTRA 1435
Query: 432 VDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 489
+DRE+ +T I D S + + ++V+DAND++P+FP + Y V D G
Sbjct: 1436 LDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGT 1495
Query: 490 SVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++ + + A
Sbjct: 1496 VVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVAR 1555
Query: 550 DNAPPAERRNS-ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE- 607
D + R + I VY+ + N + P Q + + +S + ++A D +
Sbjct: 1556 DCSIQGSRSTTVIIKVYVTDV---NDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL 1612
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN 667
G + T + Q +F++ + TG + + E ++ + G P T+T +
Sbjct: 1613 GPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLL- 1671
Query: 668 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 725
++ + D F +L + L EA + VKA PD+ I + YS+ GN + +
Sbjct: 1672 VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGV 1730
Query: 726 FRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 782
+ S T + L+ EVR+ +L+V+A + +A+ + D +DNSP F
Sbjct: 1731 LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCF 1787
Query: 783 TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 840
S Y V E+ ++Q+ A D+D G N + Y I S + F + +G ++
Sbjct: 1788 EQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Query: 841 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--SKRIYKGMV 898
LDYE +S + +V+A D + V V D+ND P F S+ + +
Sbjct: 1848 AILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV---EI 1900
Query: 899 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 958
D++ G +T V D D + + P + F +++++G V+ L+
Sbjct: 1901 TEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLD 1954
Query: 959 EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMV 1018
E T ++L++ D V + + + VL + P +++ V E G V
Sbjct: 1955 FEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSV 2011
Query: 1019 GVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTSYVLRVQAD 1073
+SA + N++I Y I+S ++E F I+ G I+ P LD + T +++
Sbjct: 2012 LTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDG 2069
Query: 1074 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1133
P V I I+D NN+ P F K Y +SEDA + ++++ D
Sbjct: 2070 G---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNID 2120
Query: 1134 KD-TGNYSVMAYRLI 1147
D T + + Y +I
Sbjct: 2121 HDWTRENTYVEYSII 2135
Score = 212 bits (539), Expect = 3e-54
Identities = 282/1097 (25%), Positives = 462/1097 (42%), Gaps = 111/1097 (10%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD 217
E VGT + A D D+G NGQ EY + ++ T+ TL +
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDRE 1543
Query: 218 VLDGDDLGPMFLPC-------------VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVT 264
+ C V V + D P+ Q +PE +P T
Sbjct: 1544 ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPE--SPTNQT 1601
Query: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
I D D ++ P +++S + F + T E+ + + ++ +
Sbjct: 1602 TVIVRAD-DLDLGPNGT---VVFSFA-----ETQSMFSIDKYTGEIQFQQNPSSEYFPIW 1652
Query: 325 DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
L +K D G P GL + ++ + F+ Y+G + E+ G T
Sbjct: 1653 -LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG---------T 1701
Query: 385 SPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYT 441
S + + A D I+D+ + +F + V ++ + LT+ +P +D E +
Sbjct: 1702 SIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCSK--SGQLTVKEPKFLDFEVRNEVQ 1757
Query: 442 FSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
+ A + + + + D NDN+P F + Y V VIQ+ A D D
Sbjct: 1758 LIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS 1816
Query: 502 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 560
G NG I Y IL G Q + F I+ +G+IT ++ + +Y+L VQA D P R ++
Sbjct: 1817 GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP--RLSN 1874
Query: 561 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 617
+ ++V N+ +P P ++EI+E G ++ ++ D + +S ++A E+
Sbjct: 1875 TTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKES 1932
Query: 618 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 677
+P F + + TG++ L K LD E Y L+I SD V ++ DVNDN
Sbjct: 1933 -NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVL--DVNDNP 1989
Query: 678 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT 736
PVF + V + ATD ++ N + Y + + + F I NG+I+T
Sbjct: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPKNGTIFT 2047
Query: 737 -AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEEN 794
+ L + + +V A+DG +P LTL I + D+++ +P FT +Y + + E+
Sbjct: 2048 ISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSED 2106
Query: 795 LPAGTTILQIEAKDVDL---GANVSYRIRSP--------EVKHFFALHPF--TGELSLLR 841
G+T++ D D V Y I S E K F + +P+ G L LL
Sbjct: 2107 ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLH 2166
Query: 842 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 901
SLD EA AS ++ A D A +++ V D+ND PP FS Y V
Sbjct: 2167 SLDREA----SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222
Query: 902 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 961
G+ IT V A D D G A + + + + F +EE++G + L+ E
Sbjct: 2223 TPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH----FYLEENTGVLYLIKPLDYEK 2277
Query: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1020
T F L V A D E S A V + VL + P+F + L T+ +
Sbjct: 2278 MTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSI 2336
Query: 1021 ISA---AAINQSIVYSIVS--------GNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1069
+ A + YSIVS + D F I+ +TG I+ LDYE Y L
Sbjct: 2337 NALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLT 2396
Query: 1070 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
VQA A+L V+++I+ + P+F + Y + E + + RV
Sbjct: 2397 VQAKDKGDATASL---------VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRV 2447
Query: 1130 KATDKDTGNYSVMAYRL 1146
+A+D D G V+ Y L
Sbjct: 2448 EASDADAGIDGVILYSL 2464
Score = 209 bits (531), Expect = 3e-53
Identities = 279/1117 (24%), Positives = 463/1117 (41%), Gaps = 109/1117 (9%)
Query: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
Query: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGD 222
TT+ A D+D GPNG + + Q++ T +
Sbjct: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA-------ETQSMFSIDKYTGEIQFQQNPSS 1646
Query: 223 DLGPMFLPCVLVPNTRDCRPLTYQAAIP------ELRTPEELNPIIVTPPIQA---IDQD 273
+ P++L + R T I ++ L +VT +A I
Sbjct: 1647 EYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTV 1706
Query: 274 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAE 331
+ P S + + YSI G + + ++ +L++ EP DF + L++ AE
Sbjct: 1707 KAFAPDSIQDSMKYSIFSGNEDGV---LSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE 1763
Query: 332 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 391
+GH A+ + + I DEN+ SP F YQ + ES A + +++ A
Sbjct: 1764 S-SGHR--AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHV---------IQVFA 1811
Query: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV 450
D D E + + F + ++ +T +D E +Y+ + A D G+
Sbjct: 1812 TDLDSGLNGLIEYSILSGNQEEAFQID--ALSGVITTKAILDYELTSSYSLIVQATDKGM 1869
Query: 451 QE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 509
S ++ +QV D NDN P F S V + D PG V ++ D D S ++
Sbjct: 1870 PRLSNTTVIKVQVTDINDNAPAFLP-SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
Query: 510 EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
F I++ TG++ + ++ Y L +Q +D+ E + + VL
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG-----ALVVRVL 1983
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITYAIENGDPQRVFNLSE 628
N+ +PP F Q Y + + E++ VG +L L ATD E ++I+Y I + + F++
Sbjct: 1984 DVND-NPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDP 2040
Query: 629 TTG-ILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVNDNAPVFDPYLPR 686
G I T+ L ++ ++ ASDG PD + V I + D+N+ AP F
Sbjct: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT-VKSY 2099
Query: 687 NLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL--GNFNNLFRITSN-------- 731
NLS+ E+ A VG T D D N V YS+ GN N F + +
Sbjct: 2100 NLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Query: 732 ---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 788
G + L+RE +ELV++A+D P ST ++I+VLD++DN P F++ +Y
Sbjct: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 789 VLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 846
V+E+ P G+ I + A D D G A + Y I S K F L TG L L++ LDYE
Sbjct: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
+ T V+A D A V V V D ND+ P F + +V + +
Sbjct: 2277 ----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISS 2331
Query: 907 PITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPASIFEVEEDSGRVITRVNLNEEP 961
I ++ A D D P + Y + F Y +F ++ +G + + L+ E
Sbjct: 2332 TICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN 2389
Query: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY---RPPPVSELATKGTMV 1018
+ L V A D G+ S V I + E P FTQ++Y P + G +
Sbjct: 2390 GNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Query: 1019 GVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1078
+ A I+ I+YS+ G F +N G IY+ L S + + ++++
Sbjct: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL--PLIKSQLNKEDTLEMKII 2504
Query: 1079 LANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1113
+ + SK + V++ + + P VF F I
Sbjct: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
Score = 206 bits (523), Expect = 2e-52
Identities = 284/1173 (24%), Positives = 462/1173 (39%), Gaps = 166/1173 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y +
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAYELI 217
Query: 193 YNPDDPDRAQNLNERRTTTTTLT--VDVLDGDDLGP---------MFLPCVL----VPNT 237
P +L +TT + V++L + MFLP + V
Sbjct: 218 -----PGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERD 272
Query: 238 RDCRPLTYQAA---IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 294
+ ++A+ + L+ + V + D + + ++ IL ++
Sbjct: 273 EEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYL- 331
Query: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 354
T LS LE L++ A+ G A + I I
Sbjct: 332 ------------TLPLSHLESTT------LSLMVSAQDGGGLTAVINADVTIHIFQTTLA 373
Query: 355 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 414
F P Y + E P SP+ V + + ++ + D
Sbjct: 374 PAEFERPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGK 423
Query: 415 FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTF 472
F++ + G R +P+D E Q ++ A G + VNI VMD NDN P F
Sbjct: 424 FSIHPRLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 480
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 532
S ++ + PG ++ A D D G NG I Y I G F I++ G++ +
Sbjct: 481 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNG 540
Query: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEA 591
+ R LT++A D + + TV IE SP F L+Y +E+SE+
Sbjct: 541 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSES 597
Query: 592 MRVGAVLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 647
+ +L QA R + Y++E +F + TG + L + D EST Y
Sbjct: 598 LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTY 657
Query: 648 ILIITA---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQ 701
+ A DG ST TV + V D NDN+P F L L + EE+ +G+
Sbjct: 658 NFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGK 713
Query: 702 VKATDPDAGINGQVHYSLGNFNNLFRITSN----GSIYTA-------------------- 737
+ A D D+G NGQ+ Y L + F++ N G+IY
Sbjct: 714 ITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDE 773
Query: 738 ---------------------VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 776
V L+RE R ++E+ V+ TD PR++T+ + + V DI+
Sbjct: 774 LQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 833
Query: 777 DNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFAL 830
DN P F V V E P + + AKD D G A V+Y + S + F +
Sbjct: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
Query: 831 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPV 888
GE+ L Y+ P S+ + +PP G A V + V ++ +
Sbjct: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQG------VPPLQGQAVVNIQVIPLSKGRAI 947
Query: 889 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV--DDVQFPYPASIFEVEE 946
S+ I + ++ P+ +K T I ++ ++ + + DD FE++
Sbjct: 948 MSQNI-RHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKD-----GHFEIDS 1001
Query: 947 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGEIPRFTQEEYRP 1005
+G + L+ E T+ + V+ D + + +SS+ + I V + Q+E
Sbjct: 1002 STGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIV 1061
Query: 1006 PPVSELATKGTMVGVISA-----AAINQSIVYSIVSGNE-EDTFGINNITGVIYVNGPLD 1059
V E GT+V V +A + +N I Y I S N + F I+ G + LD
Sbjct: 1062 ISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLD 1121
Query: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1119
E+ + +L V A V + + R+ +S TA+ I I D N+H P F F V ED
Sbjct: 1122 RESIPTVILTVTASDQAVNVTDRRL--RSLTAQ--IVILDVNDHNPTF-ISFPNAHVKED 1176
Query: 1120 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMR 1177
+ + V + A D D G + Y ++ G E F+++ +GL+ T
Sbjct: 1177 VTVGSLVHHITAHDPDEGRNGKVTYSIL-----SGNENMTFMLDESSGLLTTTCPLDYEM 1231
Query: 1178 RSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
++ V+A DD LS + V+V++ D
Sbjct: 1232 KTQHILTVLALDDGTPALSSSQTLTVTVLDVND 1264
Score = 201 bits (511), Expect = 6e-51
Identities = 292/1238 (23%), Positives = 501/1238 (40%), Gaps = 182/1238 (14%)
Query: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
Query: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
Query: 144 SP--TFKHESYYATVNE-LTPVGTTIFTG--------------FSGDNGATDIDDGPNGQ 186
SP TF+H Y V+E L+P+ + T +S + G
Sbjct: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
Query: 187 IEYVIQYNPDDPDRAQNLNER-----------RTTTTTLTVDVLDGDDLGPMFLPCVLVP 235
++ D + Q N R + +TT+ V V D +D P FL VL
Sbjct: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF- 698
Query: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN-----------------IQP 278
L+ E P V I AID D + P
Sbjct: 699 ----------------LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP 742
Query: 279 PSDRPGILYSI--------LVGTP----EDYPRFFHMHPRTAELSLLEPVN-----RDFH 321
+ G +Y I GT D + F + EL E +N R+
Sbjct: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
Query: 322 QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT--MPSYQGYI--LESAPVGATI 377
++ + P A +++ + D N+ P+F +P + ++ LE PV +
Sbjct: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
Query: 378 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREE 436
+ + A D D + + + D + F + G R T+L +
Sbjct: 863 TT---------VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILS---YDY 910
Query: 437 QQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 494
+ +Y S+ A D GV + +VNIQV+ + + + + +++P + +
Sbjct: 911 RPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLI 970
Query: 495 TAVD-ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 552
+ D + NG++ + I+ + G F I+ +TG + ++ ++ Y V D++
Sbjct: 971 KSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHS 1030
Query: 553 PPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD-- 609
+ + TV++ + + N P F + + + E + +G ++ A D +G
Sbjct: 1031 ---KNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
Query: 610 --SITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS---- 662
I Y IE+ +P F + + G L LDRES IL +TASD + T
Sbjct: 1088 NSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLR 1147
Query: 663 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL-- 719
+ T IV+ DVND+ P F + N V E+ + V + A DPD G NG+V YS+
Sbjct: 1148 SLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILS 1205
Query: 720 GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 778
GN N F + S+G + T L+ E++ + L V+A D S+ TL + VLD++D
Sbjct: 1206 GNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
Query: 779 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGE 836
+PVF Y V+EN G + ++EA D D G N + + I F ++ TGE
Sbjct: 1266 APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGE 1325
Query: 837 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIY 894
+ L D+E F + G P +T T++ V+D ND+ P F Y
Sbjct: 1326 VVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
Query: 895 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 954
V + + + TV A D D A V Y + D F + E SG + T
Sbjct: 1380 DIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---TDECFTINEMSGELSTT 1433
Query: 955 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATK 1014
L+ E + F LV++ D G+P SS +++ VL + Y V E A
Sbjct: 1434 RALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEV 1493
Query: 1015 GTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
GT+V V+SA +N Y ++ F I+ ++G + + LD E R+ +
Sbjct: 1494 GTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSA 1552
Query: 1071 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
A + S+S T + + + D N++ PV ++ + +S ++ + + V+
Sbjct: 1553 VARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606
Query: 1131 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1168
A D D G + + E + F ++ YTG I+
Sbjct: 1607 ADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
Score = 130 bits (326), Expect = 2e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 430 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 476
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Query: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 535
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Query: 536 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 594
++ ++ + ++ E + + +V + +F + + +
Sbjct: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
Query: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 652
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
Query: 653 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 703
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
Query: 704 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 760
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 761 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 818
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
Query: 819 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 878
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
Query: 879 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 934
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
Query: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 992
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
Query: 993 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1045
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
Query: 1046 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1073
N T G IYV + + ++VL+ V D
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 1074 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1123
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
Query: 1124 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1183
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
Query: 1184 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1237
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
Query: 1238 VQ 1239
Q
Sbjct: 977 QQ 978
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 701 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 751
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
Query: 752 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
Query: 801 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 854
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
Query: 855 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 909
+ + P + + +D F +KG +K
Sbjct: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
Query: 910 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
Query: 970 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 1023
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
Query: 1024 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
Query: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
Query: 1141 VMAYRLIIP 1149
++ Y + P
Sbjct: 514 LIRYSIASP 522
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 998 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1057
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 1058 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1113
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 1114 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
Score = 54.3 bits (129), Expect = 1e-06
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 18/144 (12%)
Query: 611 ITYAIENG----DPQRVFNLSETTGILTLGKALDRESTDR-YILIITASDGRPDG----- 660
I Y++ +G + + F + G + + + +DRE Y L++ A DG
Sbjct: 92 IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLA 151
Query: 661 ------TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 714
++ A V + + DVNDN PVF+P E + + V ATD D+GI G
Sbjct: 152 LVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 211
Query: 715 VHYSL--GNFNNLFRITSNGSIYT 736
V Y L GN ++LF I S +Y+
Sbjct: 212 VAYELIPGNVSSLFTIDSTTGLYS 235
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 278 bits (712), Expect = 3e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 245 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 303
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 304 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 362
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 363 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 422
Y+ + E+ G I L++ A D D + I
Sbjct: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Query: 423 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 475
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 534
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Query: 535 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
Query: 594 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
Query: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 709
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
Query: 710 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
Query: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 824
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
Query: 825 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 884
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
Query: 885 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 944
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
Query: 945 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1003
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
Query: 1004 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
Query: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1117
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
Query: 1118 EDARMFTS--VLRVKATDKDTGNY 1139
+ F S + R+ A D D ++
Sbjct: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
Score = 256 bits (654), Expect = 1e-67
Identities = 237/800 (29%), Positives = 371/800 (46%), Gaps = 90/800 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
Query: 193 YNPD-----------DP-----DRAQNLNERRTTTTTLTVDVLD-GDDLGPMFLPC---V 232
P DP + ++ + L V+ D G + GP +
Sbjct: 474 GPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHI 533
Query: 233 LVPNTRDCRP-LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSIL 290
V + D P + + + ++R E++ P V + A D+D+ D G++ Y+I+
Sbjct: 534 TVLDENDNAPQFSEKRYVAQVR--EDVRPHTVVLRVTATDRDK------DANGLVHYNII 585
Query: 291 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEIL 349
G + F + T E+ ++ P++ + +++ L I+A+ PL GL I+++
Sbjct: 586 SGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVV 642
Query: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 409
D N+ P F +Q +LE+AP+G ++ + I A+D D + E L
Sbjct: 643 DINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAVDADHGENARLEYSLTGV 693
Query: 410 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAND 467
+ F + T ++++ P+DRE + Y F + A D S V + V+D ND
Sbjct: 694 APDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
Query: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT-- 524
N P F Y + + D G SV+ +TAVD D +N I+Y+I G + F I+
Sbjct: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
Query: 525 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 584
GL+T+A ++ R + L + A+D A + C V+I + N P F Y
Sbjct: 810 VGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPV-FQSAHY 863
Query: 585 SLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDR 641
S+ ++E +G+ ++ + A+D E ITY +E+ PQ F + +G +TL LD
Sbjct: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDY 921
Query: 642 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 700
E Y L ITA D G P T V ++V DVNDNAP F +V E+A F
Sbjct: 922 EDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--VASHYTGLVSEDAPPFTS 979
Query: 701 --QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTAVKLNREVRDYYELVVVA 754
Q+ ATD DA NG+V Y+ N + F I ++G + T +L+RE YEL A
Sbjct: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
Query: 755 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG-- 812
D V P + +++ + V D++DN+PVF + V V+EN G+ + QI A D D G
Sbjct: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
Query: 813 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 872
A++ Y+I + F + F+GEL+ L LDYEA QE I + T P +
Sbjct: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVIV-------VQATSAPLV 1150
Query: 873 ATVTVIVK--DMNDYPPVFS 890
+ TV V+ D ND PV +
Sbjct: 1151 SRATVHVRLVDQNDNSPVLN 1170
Score = 246 bits (629), Expect = 1e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 353 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 410
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
Query: 411 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 466
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 520
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
Query: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 637
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
Query: 638 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
Query: 696 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 748
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
Query: 749 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 808
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
Query: 809 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 866
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
Query: 867 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 926
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
Query: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Query: 987 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1041
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
Query: 1042 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
Query: 1161 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
Score = 239 bits (611), Expect = 1e-62
Identities = 233/878 (26%), Positives = 396/878 (45%), Gaps = 79/878 (8%)
Query: 207 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 266
R + TT + V V D +D P+F Y+ + E EE PI+
Sbjct: 412 RLSATTMVAVTVADRNDHSPVF------------EQAQYRETLRE--NVEEGYPIL---Q 454
Query: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQK 323
++A D D PP+ L VG P F + PR+ +S V+R+ +
Sbjct: 455 LRATDGDA---PPNAN---LRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMES 508
Query: 324 FDLVIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 381
++LV++A P P A +HI +LDEN+ +P F+ Y + E D
Sbjct: 509 YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE---------DVR 559
Query: 382 NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
T LR+ A D+D + ++ + F + +T + ++ P+D E ++ Y
Sbjct: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYA 617
Query: 442 FSITAFDGVQ---ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 498
I A D + + + +IQV+D ND+ P F + V V + G SVI + AVD
Sbjct: 618 LRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVD 677
Query: 499 ADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAE 556
AD G N + Y + V F+IN TG ++++ ++ Y V+A D+ +PP
Sbjct: 678 ADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLS 737
Query: 557 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAI 615
S+ ++V N + P F Y L ++E VG ++++ A DR+ +S I+Y I
Sbjct: 738 ASASVTVTVLDV----NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQI 793
Query: 616 ENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDV 673
G+ + F +S G++TL LD + + L++TASD +NI TD
Sbjct: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDA 851
Query: 674 NDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 731
N + PVF ++SV E+ + + + A+D D G N ++ Y L + FRI ++
Sbjct: 852 NTHRPVFQS-AHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADS 910
Query: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
G+I L+ E + Y L + A D + + T + + V D++DN+P F S YT LV
Sbjct: 911 GAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
Query: 792 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAF 848
E+ P T++LQI A D D AN V Y ++ E F + P +G + +R LD EA
Sbjct: 971 SEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAV 1030
Query: 849 PDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
E + A+ + +PP ++ V+V+D+ND PVF ++ V +++ G+
Sbjct: 1031 SVYELT------AYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGS 1084
Query: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
+ + A D D P + + Y++ + P +F+++ SG + ++L+ E +
Sbjct: 1085 VVAQITAVDPDEG--PNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYV 1139
Query: 967 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1025
+VV A P++S + LV P + + G+I
Sbjct: 1140 IVVQA--TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
Query: 1026 ----INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
++ + YS GNE +N +G + ++ LD
Sbjct: 1198 YDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
Score = 233 bits (595), Expect = 1e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 520
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 632
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 633 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 689
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
Query: 690 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 744
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 745 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 804 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 861
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
Query: 862 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 920
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
Query: 921 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 980
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
Query: 981 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1036
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 1037 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1096
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
Query: 1097 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1156
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
Query: 1157 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
G F +E +G+++T S ++ A D
Sbjct: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
Score = 218 bits (555), Expect = 4e-56
Identities = 216/797 (27%), Positives = 348/797 (43%), Gaps = 104/797 (13%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGT-IIYHEVRIVVRDRNDNSPTFKHESYYA 154
++++GRV DR+ M + +VV+ ++ G V I V D NDN+P F + Y A
Sbjct: 495 ISTSGRV-DREH-MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
Query: 155 TVNELTPVGTTI-----------------FTGFSGDNGATDIDDGPNGQI---------- 187
V E T + + SG++ D G+I
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 188 --EYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTY 245
EY ++ D R N T ++ V+D +D P+F+ + + PL +
Sbjct: 613 EREYALRIRAQDAGRPPLSN----NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGH 668
Query: 246 QAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHP 305
IQA+D D + + YS L G D P F ++
Sbjct: 669 SVI-----------------HIQAVDADH-----GENARLEYS-LTGVAPDTP--FVINS 703
Query: 306 RTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG 365
T +S+ P++R+ + + ++A PL A A + + +LD N+ P FTM Y
Sbjct: 704 ATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHL 763
Query: 366 YILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY 425
+ E A VG TS + + A+D+D + + + F ++ G
Sbjct: 764 RLNEDAAVG---------TSVVSVTAVDRDANSA--ISYQITGGNTRNRFAISTQGGVGL 812
Query: 426 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 485
+TL P+D ++++ + +TA D + V+I + DAN + P F Y V V D
Sbjct: 813 VTLALPLDYKQERYFKLVLTASDRALH-DHCYVHINITDANTHRPVFQSAHYSVSVNEDR 871
Query: 486 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 545
G +++ ++A D D G N ITY +L F I+ +G IT+ ++ TY L
Sbjct: 872 PMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLA 930
Query: 546 VQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 604
+ A DN P + T Y+EV+ + N + P+F Y+ +SE +L + AT
Sbjct: 931 ITARDNGIPQKAD----TTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISAT 986
Query: 605 DREGDS---ITYAIENG-DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
DR+ + + Y +NG D F + T+GI+ + LDRE+ Y L A D G P
Sbjct: 987 DRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPP 1046
Query: 660 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQV 715
+ ++ ++V DVNDNAPVF P V + N+ VG Q+ A DPD G N +
Sbjct: 1047 LRTPVSIQVMVQDVNDNAPVF----PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
Query: 716 HYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 772
Y + GN LF++ +G + + L+ E R Y +VV AT P S T+ +++
Sbjct: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRATVHVRL 1159
Query: 773 LDIDDNSPVFTN-----STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHF 827
+D +DNSPV N + Y + P+G I +I A D D+ ++ Y
Sbjct: 1160 VDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQL 1218
Query: 828 FALHPFTGELSLLRSLD 844
++ +GEL L R LD
Sbjct: 1219 LVVNQTSGELRLSRKLD 1235
Score = 124 bits (310), Expect = 1e-27
Identities = 149/563 (26%), Positives = 242/563 (42%), Gaps = 64/563 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
Query: 193 Y-NPDDPDRAQNLNERRTTTTTLTVD---------VLDGDDLGPMFLPCVLVPNTRDC-- 240
N + T L +D VL D + C + N D
Sbjct: 795 GGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDANT 853
Query: 241 -RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 299
RP+ +Q+A + E+ I A D D + I Y + P+
Sbjct: 854 HRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDD-----VGENARITYLLEDNLPQ---- 903
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSPY 357
F + + ++L P++ + + L I A +DNG P A ++E++ D N+ +P
Sbjct: 904 -FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDNGIPQKADT-TYVEVMVNDVNDNAPQ 960
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN--DYTSVF 415
F Y G + E AP TS L+I A D+D + + F N D F
Sbjct: 961 FVASHYTGLVSEDAPP---------FTSVLQISATDRDAHANGRVQ-YTFQNGEDGDGDF 1010
Query: 416 TVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTF 472
T+ T GI R + L DRE Y + A D GV PV + + V D NDN P F
Sbjct: 1011 TIEPTSGIVRTVRRL---DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 531
P ++V V + G V Q+TAVD DEG N I Y+I+ G + F ++ +G +T
Sbjct: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL 1127
Query: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP-QLMYSLEISE 590
++ + Y + VQA +AP R TV++ ++ N+ SP Q++++ +S
Sbjct: 1128 IDLDYEARQEYVIVVQAT-SAPLVSR----ATVHVRLVDQNDNSPVLNNFQILFNNYVSN 1182
Query: 591 AMRV--GAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 647
++ + A D + D + Y+ E G+ ++ +++T+G L L + LD
Sbjct: 1183 RSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVA 1242
Query: 648 ILIITASDGRPDGTSTATVNIVV 670
+++T +DG T+ + +V+
Sbjct: 1243 SMLVTVTDGLHSVTAQCVLRVVI 1265
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 270 bits (689), Expect = 1e-71
Identities = 299/1119 (26%), Positives = 486/1119 (43%), Gaps = 104/1119 (9%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
Query: 192 --------QYNPDDPDRA-QNLNERRTTTTTLTVDVLDGDDLGPM-FLPCVLVPNTRDCR 241
NP+ Q L+ +T + + V+ D G + F ++ +
Sbjct: 2522 NKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDN 2581
Query: 242 PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR-F 300
P ++A+ E + N +P IQ + D + +D + YS+ PED +
Sbjct: 2582 PPQFKAS--EYTVSIQSNVSKDSPVIQVLAYDADEGQNAD---VTYSV---NPEDLVKDV 2633
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFT 359
++P T + + + + +Q D IKA QD G P + + ++++ + P F+
Sbjct: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDGGPPHWNSLVPVRLQVVPKKVSLPKFS 2692
Query: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT------S 413
P Y E P G+ I ++ VA +DP ++ + T
Sbjct: 2693 EPLYTFSAPEDLPEGSEIGI-------VKAVA-------AQDPVIYSLVRGTTPESNKDG 2738
Query: 414 VFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQESEPVIVNIQVMDANDNTP 470
VF++ TG+ + + +P+D E + Y + A V VNIQV D NDN P
Sbjct: 2739 VFSLDPDTGVIK---VRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRP 2795
Query: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FIINKTTG 526
F Y + +M G SVIQ+TA+D D G +G+++Y + + F I+ +G
Sbjct: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
Query: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
IT ++ +TY V A D+ + +S V + + N+ + PRF Y
Sbjct: 2856 WITTLQELDCETCQTYHFHVVAYDHGQTIQ-LSSQALVQVSITDENDNA-PRFASEEYRG 2913
Query: 587 EISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSET--TGILTLGKALD 640
+ E G ++ L+ D + +T I GDP F +S+ ++ K LD
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
Query: 641 RESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 700
RE T +Y+L +TASDG+ ++ TV I V DVNDN+P L + F+
Sbjct: 2974 REHTAKYLLRVTASDGK--FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031
Query: 701 QVKATDPDAGINGQVHYSL-GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGA 758
+V ATD D N Q+ YSL G + F++ + G + T L+RE +D + LV ATDG
Sbjct: 3032 KVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGG 3091
Query: 759 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 818
+ +TL ++ D++DN+P F S V V +N T + + A+D D GAN
Sbjct: 3092 GRSCQADITLHVE--DVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVV 3149
Query: 819 IRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVT 876
P+ + F++ TG + L + L +A + V A D+ +P + TVT
Sbjct: 3150 YSLPDSAEGHFSIDATTGVIRLEKPLQVR----PQAPLELTVRASDLGTPIPLSTLGTVT 3205
Query: 877 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 936
V V + DY PVF + V DA GT + + PG A + YRV
Sbjct: 3206 VSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV--LQLATLTRPG--AEKTGYRVVSGN-- 3259
Query: 937 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-I 995
F ++ +G + +L+ E + + L + +S TV + + E
Sbjct: 3260 -EQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHR 3318
Query: 996 PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGV 1051
P+F Q+ Y V E A G ++ +SA +N I YS++ GN+ F I+ G
Sbjct: 3319 PQFPQDPY-STRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGE 3377
Query: 1052 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1111
+ V LD E +SY L+++A + P + I++ D N++PP F +
Sbjct: 3378 LQVAKALDREQASSYSLKLRA-------TDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN 3430
Query: 1112 YIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAYRLIIPPIKEGKEGFVVE-TYTGLIKT 1169
Y V E++ + + VL++ +D D+ N ++R I +G G T G + T
Sbjct: 3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFR-----ITKGNNGSAFRVTPDGWLVT 3485
Query: 1170 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1208
A + +++ Q+ A+D LS V V V Q
Sbjct: 3486 AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQ 3524
Score = 254 bits (649), Expect = 6e-67
Identities = 301/1200 (25%), Positives = 498/1200 (41%), Gaps = 164/1200 (13%)
Query: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
Query: 173 DNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 232
ATD D G N + Y R++ T+ L+ G L +
Sbjct: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVL 222
Query: 233 LVPNTR---DCRPLTYQAAI-----PELRTPEELNPIIVTPP-------IQAIDQDRNIQ 277
V R + AA+ P LR P + ++VTPP + D N
Sbjct: 223 AVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-- 280
Query: 278 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL--EPVN-RDFHQKFDLVIKAEQDN 334
S ++ G P + + + R+ E SL+ + +N ++ F+L ++A +
Sbjct: 281 -SSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGS 339
Query: 335 G-HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
G + G H+ S F Y+ + E +P G+ + +R+
Sbjct: 340 GPYFYSQIRGFHLP--PSKLSSLKFEKAVYRVQLSEFSPPGSRVV-------MVRVTPAF 390
Query: 394 KDIEDTKDPE---LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 450
+++ P + LN T + T T+ +D ++ Y I G
Sbjct: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL-----------MDFHDRAHYQLHIRTSPGQ 439
Query: 451 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 510
+ +V I ++D N++ P F SYD + ++ PG SV+ +TA D D G NG +TY
Sbjct: 440 AST---VVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYS 496
Query: 511 ILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
I F I+ G+I+ + ++ ++ R Y V+A+D P R + +++++ L
Sbjct: 497 IAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEV-SIFLQ-L 554
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVFNLSE 628
N + P F ++ + I + VG ++ + A D E ++ Y I +G+ F+L+
Sbjct: 555 RNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNH 614
Query: 629 TTGILTLGKA---LDRESTDRYILIITASDGRPDGTSTATVNIVVT-------------- 671
+G+++L + L Y L ITASDG+ + S T+NI V
Sbjct: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGK-NYASPTTLNITVVKDPHFEVPVTCDKT 673
Query: 672 --------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANAF 698
+N P F+ + P+++ V+E N
Sbjct: 674 GVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTP 733
Query: 699 VGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVAT 755
+ ++ ATDPDAG NG++ Y + GN F I G + A L+ E ++Y L V
Sbjct: 734 LARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVY 793
Query: 756 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN- 814
D + S L + V D +DN+P F Y + + E+ GTTI ++ KD D N
Sbjct: 794 DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNG 853
Query: 815 -VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPG 871
V Y + SP K F+LHP TGEL + LD E+ E VEA D G
Sbjct: 854 RVRYTLLSPTEK--FSLHPLTGELVVTGHLDRES----EPRYILKVEARDQPSKGHQLFS 907
Query: 872 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 931
+ + + ++D+ND P + V D GT +T + + +DP PA VRY +
Sbjct: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT--FLDASDPDLGPAGEVRYVLM 965
Query: 932 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV- 989
D F V+ +G +I L+ E + L + A D G P+ + V+++V
Sbjct: 966 DGAH----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021
Query: 990 -----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1040
LHP F + V E + GT V V++A + ++ + Y + +G
Sbjct: 1022 DVNENLHPPHFASFVHQ----GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGL 1077
Query: 1041 DTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQD 1099
F IN TG+I PLD E + Y L V A D V L S+ +VYIE+ D
Sbjct: 1078 AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--------SSVTEVYIEVTD 1129
Query: 1100 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EG 1157
N++PP + + + EDA + TSVL++ A D D+ + + + I G
Sbjct: 1130 ANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-----ITSGNYMGF 1184
Query: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
F++ TGL+ TA + +V D+ L + V+V +++ D I S+
Sbjct: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Score = 247 bits (630), Expect = 9e-65
Identities = 273/1057 (25%), Positives = 469/1057 (44%), Gaps = 103/1057 (9%)
Query: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y + +P
Sbjct: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTL-LSPT 863
Query: 197 DPDRAQNLNERRTTT----------TTLTVDVLDGDDLG-PMFLPCVLVPNTRDCRPLTY 245
+ L T L V+ D G +F L+ D +
Sbjct: 864 EKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
Query: 246 QAAIP--ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHM 303
Q L+ PE+L P V + A D D + P + +L GT F +
Sbjct: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPD--LGPAGEVRYVLMDGAHGT-------FRV 974
Query: 304 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL----DENNQSPYFT 359
T L L ++ + ++L + A D G PL H+E++ +EN P+F
Sbjct: 975 DLMTGALILERELDFERRAGYNLSLWA-SDGGRPLARRTLCHVEVIVLDVNENLHPPHFA 1033
Query: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419
+QG + E++P G + IV +D + D EL FL T + +
Sbjct: 1034 SFVHQGQVQENSPSGTQV-----------IVVAAQDDDSGLDGELQYFLRAGTGLAAFSI 1082
Query: 420 TGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISY 477
T + L P+DRE Y ++ A D V S V I+V DANDN P + +
Sbjct: 1083 NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF 1142
Query: 478 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEM 536
+ D G SV+QL A D D S G++T+ I G G F+I+ TGL++ A ++
Sbjct: 1143 YPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDR 1202
Query: 537 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR--V 594
+ L V DN P+ + S V + +L N+ +PP F ++++ + E +
Sbjct: 1203 ENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVND-NPPIFSHKLFNVRLPERLSPVS 1259
Query: 595 GAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 651
+ L A+D + +TY+IE+ D + F++ TG+++ + + IL I
Sbjct: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSIDLVTGVVSSSSTF--TAGEYNILTI 1316
Query: 652 TASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKATDP 707
A+D G+P +++ ++I + + P+ + +V+E + N VG +
Sbjct: 1317 KATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV--- 1373
Query: 708 DAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
G G +++ G+ + F I + GSI A L+ R Y L V TDG+ +
Sbjct: 1374 -EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS--RTIA 1430
Query: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI---RS 821
T + +I+ + P F + Y V V ++ G +L+++A D D G ++ Y I +
Sbjct: 1431 TQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQD 1490
Query: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
P F L P +G L + LD + P Q ++T +V +I + VT+ V+D
Sbjct: 1491 PGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTVMVRDQEI--PIKRNFVWVTIHVED 1547
Query: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
N +PP F++ Y+ V GT + V A DAD G+ A V Y +
Sbjct: 1548 GNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD-RGVNA-EVHY---SLLKGNSEGF 1602
Query: 942 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE--IPRFT 999
F + G + L++ L V A D G P ATV I+ ++P + P F+
Sbjct: 1603 FNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATV-IIHVYPSDRSAPIFS 1661
Query: 1000 QEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
+ EY + E G+ + ++SA + ++ + Y + GN++ F +N+ +G+I LD
Sbjct: 1662 KSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELREGNKDGVFSMNSYSGLISTQKKLD 1719
Query: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1119
+E +SY L+++ ++ ++ V ++I DEN++ P+F K ++G +SE
Sbjct: 1720 HEKISSYQLKIRGSNMAGAFTDV---------MVVVDIIDENDNAPMFLKSTFVGQISEA 1770
Query: 1120 ARMFTSVLR-------VKATDKDTGNYSVMAYRLIIP 1149
A +++ ++ + A+D D S++ Y+++ P
Sbjct: 1771 APLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEP 1807
Score = 246 bits (628), Expect = 2e-64
Identities = 300/1150 (26%), Positives = 480/1150 (41%), Gaps = 128/1150 (11%)
Query: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
Query: 175 GATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGD------------ 222
A+D D G N + Y I + D + +N +T TV LD +
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSKFFQIN--GSTGEMSTVQELDYEAQQHFHVKVRAM 2352
Query: 223 DLG--PMFLPCVLVPNTRDC-------RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 273
D G P+ ++V N D R Y+A + EL T L +QAID D
Sbjct: 2353 DKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL-----VLKVQAIDPD 2407
Query: 274 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 333
D + Y IL G + R F ++ + +S+ + ++L + A
Sbjct: 2408 SR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDG 2459
Query: 334 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
A ++I + N SP F Y+ + E+A VG + D ++A+D
Sbjct: 2460 ---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVID---------LLAID 2507
Query: 394 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQ 451
KD + + + F++ G + LQ +DRE ++ + A DG
Sbjct: 2508 KDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENSTERVIAIKVMARDGGG 2564
Query: 452 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 511
V I + D NDN P F Y V + +++ VIQ+ A DADEG N ++TY +
Sbjct: 2565 RVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
Query: 512 LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 569
+ IN TG++ + + + +T ++A D PP NS+ V ++V+
Sbjct: 2625 NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP--HWNSLVPVRLQVV 2682
Query: 570 PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG-----DPQRVF 624
P S P+F + +Y+ E + G+ + ++A + D + Y++ G + VF
Sbjct: 2683 -PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPESNKDGVF 2740
Query: 625 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--D 681
+L TG++ + K +D EST Y + + A D S +VNI V DVNDN PVF D
Sbjct: 2741 SLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEAD 2800
Query: 682 PY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNNLFRITS-NG 732
PY L N+ V V QV A D D G +GQV Y L N + LF I S +G
Sbjct: 2801 PYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
Query: 733 SIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
I T +L+ E Y VVA D G S + + + D +DN+P F + Y V
Sbjct: 2856 WITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915
Query: 792 EENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYE 846
EN G + ++ D D+ V+ I + F + E +S ++L
Sbjct: 2916 VENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTL--- 2972
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
D+E + +L+ G + TV + V D+ND P S+ +Y G V D G
Sbjct: 2973 ---DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
Query: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
I V A D D +++ Y + A F+++ +G + T L+ E +F
Sbjct: 3029 FILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFN 3082
Query: 967 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1023
LV A D G + T+ + ++ PRF + V + T T V V+ A
Sbjct: 3083 LVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFDNTTVKTPVAVVFARDP 3140
Query: 1024 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1082
N +VYS+ + E F I+ TGVI + PL + L V+A L +
Sbjct: 3141 DQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPI--- 3196
Query: 1083 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1142
S V + + ++ PVF + V EDA T VL++ + +
Sbjct: 3197 ---PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKT-- 3251
Query: 1143 AYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1201
YR ++ ++G+ F ++ TG++ A L YF ++ + K S +DV
Sbjct: 3252 GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF----LSIECSRKSSSSLSDV 3304
Query: 1202 LVSVVNQLDM 1211
+VN D+
Sbjct: 3305 TTVMVNITDV 3314
Score = 241 bits (614), Expect = 6e-63
Identities = 222/788 (28%), Positives = 352/788 (44%), Gaps = 50/788 (6%)
Query: 372 PVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLL 429
P + +S+ + +PL R+ A D D + + F + +TG+ LT+
Sbjct: 719 PQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGL---LTVA 775
Query: 430 QPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP 487
P+D E Y ++T +D Q+S ++ + V D NDN P FP Y + + D
Sbjct: 776 APLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV 835
Query: 488 GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQ 547
G ++ +LT DAD NG + Y +L + F ++ TG + + ++ Y L V+
Sbjct: 836 GTTIAELTTKDADSEDNGRVRYTLLSPTE-KFSLHPLTGELVVTGHLDRESEPRYILKVE 894
Query: 548 AADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
A D + S+ + I + N+ SP + L++ E + G VL L A+D +
Sbjct: 895 ARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITE-HNRLKVPEDLPPGTVLTFLDASDPD 953
Query: 608 ---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTST 663
+ Y + +G F + TG L L + LD E Y L + ASD GRP T
Sbjct: 954 LGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRT 1012
Query: 664 -ATVNIVVTDVNDN--APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
V ++V DVN+N P F ++ + + V V A D D+G++G++ Y L
Sbjct: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLR 1072
Query: 721 NFNNLFRITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
L + N G I T L+RE YY L V+A D P S + I+V D +D
Sbjct: 1073 AGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDAND 1132
Query: 778 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA--NVSYRIRSPEVKHFFALHPFTG 835
N P + + + ++E+ P GT++LQ++A D D + +++ I S FF +HP TG
Sbjct: 1133 NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTG 1192
Query: 836 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
LS + LD E + +T L D + V V + D+ND PP+FS +++
Sbjct: 1193 LLSTAQQLDRENKDEHILEVTVL----DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFN 1248
Query: 896 GMVAP--DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 953
+ V P+ + A D D GL RV Y ++D F ++ +G V +
Sbjct: 1249 VRLPERLSPVSPGPVYRLVASDLD-EGL-NGRVTYSIEDSD----EEAFSIDLVTGVVSS 1302
Query: 954 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSE 1010
I L + A D G+P +S+S + I + P IP E Y V E
Sbjct: 1303 SSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVME 1360
Query: 1011 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1070
MVGVIS ++I G+++ F I TG I + PLD R++Y L V
Sbjct: 1361 TDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTV 1420
Query: 1071 QADSLEVVLANLRVPSKSNTAKVYI-EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
+ S++ +V+I I + N+H P F + Y V +D +LRV
Sbjct: 1421 EVTD----------GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRV 1470
Query: 1130 KATDKDTG 1137
+A D+D G
Sbjct: 1471 QAIDQDKG 1478
Score = 234 bits (598), Expect = 5e-61
Identities = 273/1078 (25%), Positives = 456/1078 (42%), Gaps = 149/1078 (13%)
Query: 207 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 266
++++ LTV+V D +D P F P YQ I E E+ I
Sbjct: 799 QKSSWKLLTVNVKDWNDNAPRF------------PPGGYQLTISE---DTEVGTTIAELT 843
Query: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 326
+ D + D + Y++L T + F +HP T EL + ++R+ ++ L
Sbjct: 844 TKDADSE-------DNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYIL 891
Query: 327 VIKA--EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
++A + GH L + L I + D N+ SP + + E P G ++
Sbjct: 892 KVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT------ 945
Query: 385 SPLRIVALDKDIEDTKDPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 437
D DP+L ++ ++ F V +T L L + +D E +
Sbjct: 946 -----------FLDASDPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERR 992
Query: 438 QTYTFSITAFDG---VQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVI 492
Y S+ A DG + V + V+D N+N P F + V + G VI
Sbjct: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVI 1052
Query: 493 QLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 551
+ A D D G +GE+ Y + G F IN+ TG+I ++ Y LTV A D
Sbjct: 1053 VVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDR 1112
Query: 552 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS- 610
+ +S+ VYIEV N+ +PP+ Q ++ I E VG +L L A D + S
Sbjct: 1113 G--SVPLSSVTEVYIEVTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169
Query: 611 --ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 667
+T+ I +G+ F + TG+L+ + LDRE+ D +IL +T D G P ST+ V
Sbjct: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229
Query: 668 IVVTDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 722
+ + DVNDN P+ F+ LP LS V V ++ A+D D G+NG+V YS+ +
Sbjct: 1230 VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDS 1286
Query: 723 NN-------LFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 775
+ + + S+ S +TA +Y L + ATD P +++ L I+ +
Sbjct: 1287 DEEAFSIDLVTGVVSSSSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPW 1339
Query: 776 DDNSPV---FTNSTYTVLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 830
S + F + Y+ V E P ++ +E + N+S + + F +
Sbjct: 1340 PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDI 1395
Query: 831 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 890
TG + + R LD + ++ VE D G+ ++ ++N + P F
Sbjct: 1396 EKTTGSIVIARPLDTR----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFL 1449
Query: 891 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 950
+ Y+ V D V G + V A D D + Y + Q P AS+F+++ SG
Sbjct: 1450 ETRYEVRVPQDTVPGVELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGV 1505
Query: 951 VIT--RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYR 1004
++T +++L P+ L V+ D P+ + V I V LHP PRFTQ Y
Sbjct: 1506 LVTVGKLDLGSGPSQ-HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYE 1561
Query: 1005 PPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1061
+A ++ V + A +N + YS++ GN E F IN + G+I + LD
Sbjct: 1562 ASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA 1621
Query: 1062 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1121
+ L V+A+ + P + A V I + + P+F K Y + E
Sbjct: 1622 NHAPHTLTVKAE-------DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIP 1674
Query: 1122 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRS 1179
+ + +L V A Y ++EG K+G F + +Y+GLI T + + S
Sbjct: 1675 VGSPILLVSAMSPSEVTYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKIS 1724
Query: 1180 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1237
++ ++ G ++G ++ VV+ +D N P L + ++E Y
Sbjct: 1725 SYQLKI-----RGSNMAGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
Score = 231 bits (590), Expect = 4e-60
Identities = 277/1128 (24%), Positives = 469/1128 (41%), Gaps = 134/1128 (11%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
Query: 192 ---------QYNPDDP--DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP--NTR 238
+P AQ L+ L V VLD + V+V +
Sbjct: 1177 TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236
Query: 239 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 298
D P+ + + +R PE L+P+ P + + D + G+ + +
Sbjct: 1237 DNPPI-FSHKLFNVRLPERLSPVSPGPVYRLVASDLD-------EGLNGRVTYSIEDSDE 1288
Query: 299 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY- 357
F + T +S + L IKA PL A LHIE + S
Sbjct: 1289 EAFSIDLVTGVVSSSSTFTAGEYNI--LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIP 1346
Query: 358 --FTMPSYQGYILESAPVGATISDSLNLTSP----LRIVALDKDIEDTKDPELHLFLNDY 411
F Y ++E+ PV + P I DKD++
Sbjct: 1347 LAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD-------------- 1392
Query: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471
F + +T T + + +P+D + Y ++ DG + + + + N + P
Sbjct: 1393 ---FDIEKT--TGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQ 1447
Query: 472 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----VGAQGDFIINKTTGL 527
F E Y+V V D PG ++++ A+D D+G + + Y I G+ F ++ ++G+
Sbjct: 1448 FLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGV 1505
Query: 528 ITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
+ +++ G + + LTV D P +R T+++E N PPRF QL Y
Sbjct: 1506 LVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE---DGNLHPPRFTQLHYEA 1562
Query: 587 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
+ + + G LL ++A D + + Y++ G+ + FN++ GI+TL + LD+ +
Sbjct: 1563 SVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQAN 1622
Query: 644 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQ- 701
+ L + A D G P ATV I V + +AP+F ++ VE + VG
Sbjct: 1623 HAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFS----KSEYFVEIPESIPVGSP 1678
Query: 702 ---VKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVAT 755
V A P +V Y L GN + +F + S +G I T KL+ E Y+L + +
Sbjct: 1679 ILLVSAMSPS-----EVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGS 1733
Query: 756 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ-------IEAKD 808
+ A + + + + ++D +DN+P+F ST+ + E P + I+ I A D
Sbjct: 1734 NMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASD 1791
Query: 809 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 866
D AN + Y+I PE FF + P G L+++ +DYE+ P S F V D
Sbjct: 1792 SDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMP----SFQFCVYVHDQGS 1847
Query: 867 TM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924
+ P A V + V+D+ND PP FS++IY+ + G + V A D D S
Sbjct: 1848 PVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED------S 1901
Query: 925 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 984
V Y + +I V +G + LN + + + + DG + +A
Sbjct: 1902 EVNYSIKTGNADEAVTIHPV---TGSISV---LNPAFLGLSRKLTIRASDG--LYQDTAL 1953
Query: 985 VKILVLHP-GEIPRFTQEEYRPPPVSELATKGTMVGVISAAA--INQSIVYSIVSGNEED 1041
VKI + + +F Q+ Y L + +V ++ A +N ++ Y +++G D
Sbjct: 1954 VKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALV-ILGAQGNHLNDTLSYFLLNGT--D 2010
Query: 1042 TFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
F + GV+ G D E + ++ L V+ + + R P + V + I+D
Sbjct: 2011 MFHMVQSAGVLQTRGVAFDREQQDTHELAVE-------VRDNRTPQRVAQGLVRVSIEDV 2063
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
N++PP F+ Y + + + +V ATD+D G + Y E F +
Sbjct: 2064 NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFA-----EDYTYFRI 2118
Query: 1161 ETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1208
+ Y G I F + + +VIA D L + +VLV+V N+
Sbjct: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNK 2166
Score = 214 bits (544), Expect = 8e-55
Identities = 267/1095 (24%), Positives = 452/1095 (41%), Gaps = 101/1095 (9%)
Query: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNG 185
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
Query: 186 QIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLV-----PNTRDC 240
+ Y I +P+ + + T V +D + + P F CV V P
Sbjct: 1799 LLVYKIL----EPEALKFFKIDPSMGTLTIVSEMDYESM-PSFQFCVYVHDQGSPVLFAP 1853
Query: 241 RPLTYQAAIPEL-----RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 295
RP + ++ R E++ + + PI + ++ + + YSI G +
Sbjct: 1854 RPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNAD 1913
Query: 296 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI-EILDENNQ 354
+ +HP T +S+L P +K L I+A D + A + + ++LD++ Q
Sbjct: 1914 EAVT---IHPVTGSISVLNPAFLGLSRK--LTIRAS-DGLYQDTALVKISLTQVLDKSLQ 1967
Query: 355 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 414
F Y + E NL +V L D + LN
Sbjct: 1968 ---FDQDVYWAAVKE------------NLQDRKALVILGAQGNHLNDTLSYFLLNGTDMF 2012
Query: 415 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTF 472
V G+ + T DRE+Q T+ ++ D Q +V + + D NDN P F
Sbjct: 2013 HMVQSAGVLQ--TRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKF 2070
Query: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 532
+ Y + PGD + Q++A D D G+NG +TYE F I+ G I++
Sbjct: 2071 KHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY-FRIDPYLGDISLKK 2129
Query: 533 GVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 592
+ Y L V A D P+ + V + N+S P F Y + + E +
Sbjct: 2130 PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR-----NKSNPLFQSPYYKVRVPENI 2184
Query: 593 RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 652
+ +L+ QA EG + Y I +P +F TG+LT+ LD ES +++ +
Sbjct: 2185 TLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVR 2244
Query: 653 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
A+D S ATV ++V DVNDN P F + A V Q+ A+D D+G N
Sbjct: 2245 ATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRN 2304
Query: 713 GQVHYSL----GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT 767
V Y + + + F+I S G + T +L+ E + ++ + V A D P
Sbjct: 2305 RDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETL 2364
Query: 768 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL--GANVSYRIRSPEVK 825
+ + V DI+DN P F Y V E G +L+++A D D + + Y I S
Sbjct: 2365 VVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQD 2424
Query: 826 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMN 883
F ++ +G +S+ ++S V A D T+P I T + N
Sbjct: 2425 RHFFINSSSGIISMFNLCKKHL----DSSYNLRVGASDGVFRATVPVYINTT-----NAN 2475
Query: 884 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 943
Y P F + +Y+ +A +A+ GT + + A D D P + Y + + SI
Sbjct: 2476 KYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG--PYGTIDYTIINKLASEKFSI-- 2531
Query: 944 VEEDSGRVITRVNLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1000
+G++ T L+ E +T + + V+A D G V + TVKI++ + P+F
Sbjct: 2532 --NPNGQIATLQKLDRENSTERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKA 2587
Query: 1001 EEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGN-EEDTFGINNITGVIYVNG 1056
EY S ++ ++ V++ A N + YS+ + +D IN +TGV+ V
Sbjct: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKD 2647
Query: 1057 PL-DYETRT-SYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1114
L E +T + ++ Q P ++ V +++ + P F + Y
Sbjct: 2648 SLVGLENQTLDFFIKAQDGG---------PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTF 2698
Query: 1115 GVSEDARMFTSVLRVKA-TDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAML 1172
ED + + VKA +D YS++ R P + K+G F ++ TG+IK
Sbjct: 2699 SAPEDLPEGSEIGIVKAVAAQDPVIYSLV--RGTTP--ESNKDGVFSLDPDTGVIKVRKP 2754
Query: 1173 FHNMRRSYFKFQVIA 1187
+ ++ V+A
Sbjct: 2755 MDHESTKLYQIDVMA 2769
Score = 205 bits (522), Expect = 3e-52
Identities = 232/853 (27%), Positives = 346/853 (40%), Gaps = 99/853 (11%)
Query: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
Query: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDP--------------DRAQNLNERRTTTTTLT 215
A D D G +GQ+ Y + +P Q L+ T
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874
Query: 216 VDVLDGDD---LGPMFLPCVLVPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQ 268
V D L L V + + D P Y+ ++ E P EL + T
Sbjct: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934
Query: 269 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 328
+Q+R + L + D R +S + ++R+ K+ L +
Sbjct: 2935 ISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISSRKTLDREHTAKYLLRV 2984
Query: 329 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 388
A A + I +LD N+ SP + Y G + E G I L+
Sbjct: 2985 TASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFI---------LK 3032
Query: 389 IVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
+ A D D + P H F D TG LT L +DRE + +
Sbjct: 3033 VSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---ELTTLTALDRERKDVFN 3082
Query: 442 FSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
A DG S + + V D NDN P F V V+ + V + A D D+
Sbjct: 3083 LVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQ 3142
Query: 502 GSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 561
G+N ++ Y + A+G F I+ TTG+I + +++ LTV+A+D P +++
Sbjct: 3143 GANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP-LSTL 3201
Query: 562 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSIT-YAIENGDP 620
TV + V+ + P F +S+++ E G +L L R G T Y + +G+
Sbjct: 3202 GTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNE 3260
Query: 621 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-TATVNIVVTDVNDNAPV 679
Q F L TGIL + +LD E++ +Y L I S S TV + +TDVN++ P
Sbjct: 3261 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQ 3320
Query: 680 F--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSLGNFNNLFRIT---S 730
F DPY R L NA VG V ATD D +N + YSL N L T
Sbjct: 3321 FPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPK 3374
Query: 731 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 790
G + A L+RE Y L + ATD P H +AI+V D++DN P F Y+
Sbjct: 3375 KGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTT 3434
Query: 791 VEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 847
V+EN P G+ +LQ+ D D G S+RI F + P G L L A
Sbjct: 3435 VQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRA 3493
Query: 848 FPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 905
+ ++A D +PP + +V V V + + Y P V D +G
Sbjct: 3494 ----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQG 3547
Query: 906 TPITTVYAEDADP 918
+ ++A D DP
Sbjct: 3548 GMVGKIHATDRDP 3560
Score = 197 bits (500), Expect = 1e-49
Identities = 251/1047 (23%), Positives = 423/1047 (40%), Gaps = 92/1047 (8%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
Query: 195 PDDPDRA----------QNLNERRTTTTTLTVDVLDGDDLGPMFLPC----VLVPNTRDC 240
R + L+ R L++ DG C +++ +
Sbjct: 968 AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
Query: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
P + + + + + E + A D D + + Y + GT
Sbjct: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGE-----LQYFLRAGTGL---AA 1079
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
F ++ T + L P++R+F + L + A PL + ++IE+ D N+ P +
Sbjct: 1080 FSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQ 1139
Query: 361 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 420
+ I E APVG TS L++ A D D ++ +Y F +
Sbjct: 1140 AVFYPSIQEDAPVG---------TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHP- 1189
Query: 421 GITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYD 478
+T L+ Q +DRE + + +T D + S V + ++D NDN P F ++
Sbjct: 1190 -VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFN 1248
Query: 479 VYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM 536
V + + P V +L A D DEG NG +TY I + F I+ TG+++ +
Sbjct: 1249 VRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSS--TF 1306
Query: 537 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-PNNQS-PPRFPQLMYSLEISEAMRV 594
G LT++A D+ P ++ ++IE +P P S P F + YS + E V
Sbjct: 1307 TAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPV 1364
Query: 595 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 654
++ + R G + I GD F++ +TTG + + + LD Y L + +
Sbjct: 1365 NHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVT 1423
Query: 655 DGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--I 711
DG T V+I ++ ++N + P F + + +V+A D D G +
Sbjct: 1424 DG--SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSL 1481
Query: 712 NGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REVRDYYELVVVATDGAVHPRHSTLTL 768
+H S +LF++ S+G + T KL+ + L V+ D + + + + +
Sbjct: 1482 IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWV 1541
Query: 769 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 826
I V D + + P FT Y V + + GT +LQ+ A D D G N V Y + +
Sbjct: 1542 TIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEG 1601
Query: 827 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 886
FF ++ G ++L + LD A T V+A D +ATV + V +
Sbjct: 1602 FFNINALLGIITLAQKLDQA----NHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSA 1657
Query: 887 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 946
P+FSK Y + G+PI V A + S V Y + + +F +
Sbjct: 1658 PIFSKSEYFVEIPESIPVGSPILLVSA-------MSPSEVTYELREGN---KDGVFSMNS 1707
Query: 947 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY--- 1003
SG + T+ L+ E + ++L + + V I + P F + +
Sbjct: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDI-IDENDNAPMFLKSTFVGQ 1766
Query: 1004 ---RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1056
P S + K VI A+ N +VY I+ F I+ G + +
Sbjct: 1767 ISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVS 1826
Query: 1057 PLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1115
+DYE+ S+ V D VL R A+V I ++D N+ PP F ++ Y
Sbjct: 1827 EMDYESMPSFQFCVYVHDQGSPVLFAPR------PAQVIIHVRDVNDSPPRFSEQIYEVA 1880
Query: 1116 VSEDARMFTSVLRVKATDKDTG-NYSV 1141
+ +L V+A+D+D+ NYS+
Sbjct: 1881 IVGPIHPGMELLMVRASDEDSEVNYSI 1907
Score = 191 bits (484), Expect = 8e-48
Identities = 269/1109 (24%), Positives = 458/1109 (41%), Gaps = 130/1109 (11%)
Query: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
Query: 183 PNGQIEYVIQYNPDDPDRAQNLNERRT---------------TTTTLTVDVLDGDDLGPM 227
+ + Y+ + + +E+ + T + VD++D +D PM
Sbjct: 1698 NKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPM 1757
Query: 228 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 287
FL V + PL + + NP + I A D D+ ++Y
Sbjct: 1758 FLKSTFVGQISEAAPLY------SMIMDKNNNPFV----IHASDSDKEANSL-----LVY 1802
Query: 288 SILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL---PAFAGL 344
IL PE +FF + P L+++ ++ + F + D G P+ P A +
Sbjct: 1803 KIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQFCVYV-HDQGSPVLFAPRPAQV 1858
Query: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
I + D N+ P F+ Y+ I+ G + L + A D +D E+
Sbjct: 1859 IIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL---------LMVRASD------EDSEV 1903
Query: 405 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 464
+ + + VT +T +++L P + T I A DG+ + + +V I +
Sbjct: 1904 NYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT--IRASDGLYQ-DTALVKISLTQ 1960
Query: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 524
D + F + Y V +++ +++ L A N ++Y +L G ++
Sbjct: 1961 VLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNGTDMFHMVQSA 2018
Query: 525 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 584
L T + T+ L V+ DN P + V IE + N +PP+F L Y
Sbjct: 2019 GVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDV---NDNPPKFKHLPY 2075
Query: 585 SLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
I + G VL + ATD + G + E + F + G ++L K D ++
Sbjct: 2076 YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQA 2135
Query: 644 TDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPVF-DPY----LPRNLSVVEEEAN 696
++Y L + A DG GT + + ++VT N + P+F PY +P N+++
Sbjct: 2136 LNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTP--- 2189
Query: 697 AFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELVVV 753
+ +A P+ G+ ++ Y++ L T++ G + L+ E + + V
Sbjct: 2190 --ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVR 2244
Query: 754 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 813
ATD A+ S T+ + V D++DN P F+ YT + E LPA T ++Q+ A D D G
Sbjct: 2245 ATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR 2303
Query: 814 N--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 869
N VSY+I +V FF ++ TGE+S ++ LDYEA + V A D
Sbjct: 2304 NRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA----QQHFHVKVRAMDKGDPPL 2359
Query: 870 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 929
G V V V D+ND PP F + Y+ V+ A G + V A DP SR+ Y
Sbjct: 2360 TGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQA--IDPDSRDTSRLEYL 2417
Query: 930 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 989
+ F + SG +I+ NL ++ + V DG V ++ V I
Sbjct: 2418 ILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYNLRVGASDG--VFRATVPVYINT 2471
Query: 990 LHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAAAINQ------SIVYSIVSGNEE 1040
+ + P F Q Y +ELA + MVG VI AI++ +I Y+I++
Sbjct: 2472 TNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLAS 2526
Query: 1041 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
+ F IN G I LD E T V+ ++ + + + V I + DE
Sbjct: 2527 EKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-------GGGRVAFCTVKIILTDE 2578
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
N++PP F+ Y + + + V++V A D D G + + Y + P K+ +
Sbjct: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYS--VNPEDLVKDVIEI 2636
Query: 1161 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
TG++K + F + A D
Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
Score = 186 bits (472), Expect = 2e-46
Identities = 245/978 (25%), Positives = 414/978 (42%), Gaps = 116/978 (11%)
Query: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
Query: 191 IQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT-----Y 245
++ A ++N+ T T+ LD + +L + V R PL+ Y
Sbjct: 1071 LRAGTG--LAAFSINQ--DTGMIQTLAPLDREFASYYWLTVLAV--DRGSVPLSSVTEVY 1124
Query: 246 QAAIPELRTPEELNPIIVTPPIQ--------AIDQDRNIQPPSDRPGILYSILVGTPEDY 297
P +++ + P IQ + D S + + ++I G +Y
Sbjct: 1125 IEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG---NY 1181
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSP 356
FF +HP T LS + ++R+ + L + DNG P L + + + + ILD N+ P
Sbjct: 1182 MGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LDNGEPSLKSTSRVVVGILDVNDNPP 1240
Query: 357 YFTMPSYQGYILESAPVGATISDSLNLTSP---LRIVALDKD----------IEDTKDPE 403
F+ + + + L+ SP R+VA D D IED+ +
Sbjct: 1241 IFSHKLF----------NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEA 1290
Query: 404 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVM 463
+ L T V + + T +L +I A D Q V + +
Sbjct: 1291 FSIDL--VTGVVSSSSTFTAGEYNIL-------------TIKATDSGQPPLSASVRLHIE 1335
Query: 464 DANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 520
P+ +++D Y +T M D V + V + EG G + I G + DF
Sbjct: 1336 WIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGVISVEGRPGLFWFNISGGDKDMDFD 1394
Query: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
I KTTG I IA ++ Y LTV+ D + R V+I ++ N P+F
Sbjct: 1395 IEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS-----RTIATQVHIFMIANINHHRPQFL 1449
Query: 581 QLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENG-DP--QRVFNLSETTGIL-TL 635
+ Y + + + G LL +QA D++ G S+ Y I DP +F L ++G+L T+
Sbjct: 1450 ETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTV 1509
Query: 636 GKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 694
GK ++ L + D P + V I V D N + P F L SV +
Sbjct: 1510 GKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRF-TQLHYEASVPDTI 1568
Query: 695 A-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYEL 750
A + QV+A D D G+N +VHYSL GN F I + G I A KL++ + L
Sbjct: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTL 1628
Query: 751 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
V A D H T+ I V D ++P+F+ S Y V + E++P G+ IL + A
Sbjct: 1629 TVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMS-- 1686
Query: 811 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 870
+ V+Y +R F+++ ++G +S + LD+E +S + ++ G
Sbjct: 1687 -PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI----SSYQLKIRGSNMAGAFTD 1741
Query: 871 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV-------KGTPITTVYAEDADPPGLPA 923
+ V +I D ND P+F K + G ++ A K ++A D+D
Sbjct: 1742 VMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEA--N 1797
Query: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
S + Y++ + P F+++ G + ++ E F+ V D G PV+ +
Sbjct: 1798 SLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR 1854
Query: 984 TVKILVLHPGEI----PRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNE 1039
++ ++H ++ PRF+++ Y V + G + ++ A+ + + YSI +GN
Sbjct: 1855 PAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPGMELLMVRASDEDSEVNYSIKTGNA 1912
Query: 1040 EDTFGINNITGVIYVNGP 1057
++ I+ +TG I V P
Sbjct: 1913 DEAVTIHPVTGSISVLNP 1930
Score = 173 bits (439), Expect = 1e-42
Identities = 183/727 (25%), Positives = 307/727 (42%), Gaps = 72/727 (9%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
Query: 193 YNP---------DDPDRAQN---LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP---NT 237
+P D R + L+ T L V DG + + ++ N+
Sbjct: 2949 GDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNS 3008
Query: 238 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 297
C L Y + E P I+ +D D N Q I YS+ +
Sbjct: 3009 PQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDTDTNAQ-------ITYSLHGPGAHE- 3057
Query: 298 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 357
F + P T EL+ L ++R+ F+LV KA G A LH+E D N+ +P
Sbjct: 3058 ---FKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPR 3112
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
F PS+ + D+ + +P+ +V + ++ + F++
Sbjct: 3113 F-FPSH---------CAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSI 3162
Query: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 474
T T + L +P+ Q ++ A D + S V + V+ D P F
Sbjct: 3163 DAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
Query: 475 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 533
+ V V D PG V+QL + + Y ++ G QG F ++ TG++ +
Sbjct: 3221 TEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGYRVVSGNEQGRFRLDARTGILYVNAS 3278
Query: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
++ Y L+++ + + + + + TV + + N P +FPQ YS + E
Sbjct: 3279 LDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNITDVNEHRP-QFPQDPYSTRVLENAL 3335
Query: 594 VGAVLLNLQATDREG---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
VG V+L + ATD +G ITY++ G+ F + G L + KALDRE Y L
Sbjct: 3336 VGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLK 3395
Query: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKAT 705
+ A+D G+P + I V DVNDN P F N S +E N+ +G Q+ +
Sbjct: 3396 LRATDSGQPPLHEDTDIAIQVADVNDNPPRF---FQLNYSTTVQE-NSPIGSKVLQLILS 3451
Query: 706 DPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
DPD+ NG + + GN + FR+T +G + TA L+R +++Y+L + A+D + P
Sbjct: 3452 DPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL 3511
Query: 763 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 822
S ++ + V + +P + V E+ G + +I A D D ++Y +
Sbjct: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEE 3571
Query: 823 EV--KHF 827
E +HF
Sbjct: 3572 ETLGRHF 3578
Score = 159 bits (401), Expect = 3e-38
Identities = 201/870 (23%), Positives = 359/870 (41%), Gaps = 131/870 (15%)
Query: 432 VDREEQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 490
++RE + +YT I A + E E + V + ++D ND P F SY V + DM
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
Query: 491 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 550
+ ++TA DAD G N E Y ++ F I+ T+G++T+A + + + L V A D
Sbjct: 167 ICKVTATDADLGQNAEFYYAFNTRSE-MFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
Query: 551 NAPPAERRN---SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
N S+ + + V P + P ++ + ++ VL++ ++ E
Sbjct: 226 RMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAE 285
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN 667
+S+ + GDP + F KA+ + +++ D N
Sbjct: 286 VESV--EVVGGDPGKHF------------KAIKSYARSNEFSLVSVKDIN-WMEYLHGFN 330
Query: 668 IVVTDVNDNAPVFDPYL------PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGN 721
+ + + + P F + P LS ++ E + Q+ P V +
Sbjct: 331 LSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA- 389
Query: 722 FNNLFRITSNGSIYTAVKLN--------REVRDYYELVVVATDGAVHPRHSTLTLAIKVL 773
F NL + S KLN ++ D+++ P ++ + I ++
Sbjct: 390 FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVIDIV 449
Query: 774 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 831
D ++++P+F S+Y ++EN+P GT++L + A D D G N V+Y I P+ F++
Sbjct: 450 DCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSID 508
Query: 832 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVF 889
P+ G +S + +DYE + TF V A D +G+ V++ ++++ND P+F
Sbjct: 509 PYLGIISTSKPMDYEL---MKRIYTFRVRASD-WGSPFRREKEVSIFLQLRNLNDNQPMF 564
Query: 890 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPYPASIFEVEE 946
+ G + D G I T+ A D D ++Y + +++++ F++
Sbjct: 565 EEVNCTGSIRQDWPVGKSIMTMSAIDVD----ELQNLKYEIVSGNELEY------FDLNH 614
Query: 947 DSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL------------H 991
SG + + +NL T + L + A D +S T+ I V+
Sbjct: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGKN--YASPTTLNITVVKDPHFEVPVTCDK 672
Query: 992 PGEIPRFTQ---------------------------------EEYRPPPVSELATK--GT 1016
G + +FT+ E++ P + L + T
Sbjct: 673 TGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINT 732
Query: 1017 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
+ ++A A N +VY I GNEE F I TG++ V PLDYE Y+
Sbjct: 733 PLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYI----- 787
Query: 1073 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
L V + +L P KS+ + + ++D N++ P F Y +SED + T++ +
Sbjct: 788 --LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTK 845
Query: 1133 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFKFQVIATDDY 1191
D D+ + + Y L+ P E F + TG L+ T L Y +V A D
Sbjct: 846 DADSEDNGRVRYTLLSP-----TEKFSLHPLTGELVVTGHLDRESEPRYI-LKVEARDQP 899
Query: 1192 GKG--LSGKADVLVSV--VNQLDMQVIVSN 1217
KG L D+++++ VN Q I +
Sbjct: 900 SKGHQLFSVTDLIITLEDVNDNSPQCITEH 929
Score = 155 bits (392), Expect = 4e-37
Identities = 233/1010 (23%), Positives = 410/1010 (40%), Gaps = 179/1010 (17%)
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 359
F + +++ +LL NR+ + L+I+A + L A + + ILD+N+ P F+
Sbjct: 94 FLRIRTKSSNTALL---NREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDLKPLFS 149
Query: 360 MPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT 418
PSY+ TIS+ + L SP+ ++ A D D+ ++ E + N + +F +
Sbjct: 150 PPSYR----------VTISEDMPLKSPICKVTATDADL--GQNAEFYYAFNTRSEMFAIH 197
Query: 419 QT-GITRYLTLLQPVDREEQQTYTFSITAFDGVQESE-------------------PVIV 458
T G+ L R + + ++ + E P I
Sbjct: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIA 257
Query: 459 NIQVM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 516
++ V D+ND T +Y + G V + V D G + + A
Sbjct: 258 SVVVTPPDSNDGT------TYATVLVDANSSGAEVESVEVVGGDPGKHFK--------AI 303
Query: 517 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV----LPPN 572
+ + L+++ M + L++QA + P Y ++ LPP+
Sbjct: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGP--------YFYSQIRGFHLPPS 355
Query: 573 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGI 632
S +F + +Y +++SE G+ ++ ++ T ++ Y ++ F L+ TG+
Sbjct: 356 KLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTP-AFPNLQYVLKPSSENVGFKLNARTGL 414
Query: 633 LTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF---------DPY 683
+T K +D Y L I S G+ ++ V I + D N++AP+F D
Sbjct: 415 ITTTKLMDFHDRAHYQLHIRTSPGQ----ASTVVVIDIVDCNNHAPLFNRSSYDGTLDEN 470
Query: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL-FRITSN-GSIYTAVKLN 741
+P SV+ V ATD D G NG V YS+ L F I G I T+ ++
Sbjct: 471 IPPGTSVL---------AVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMD 521
Query: 742 RE-VRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 799
E ++ Y V A+D G+ R +++ +++ +++DN P+F T + ++ P G
Sbjct: 522 YELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGK 581
Query: 800 TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
+I+ + A DVD N+ Y I S +F L+ F+G +SL R Q S + +
Sbjct: 582 SIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPF-INLTAGQPTSYSLKI 640
Query: 860 EAFDIYGTMPPGIATVTVIVKD-------------------------------------- 881
A D P +TV VKD
Sbjct: 641 TASDGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEF 699
Query: 882 -------MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA--DPPGLPASRVRYRVDD 932
+N Y P F + + D ++ PI T A A DP ++ Y + D
Sbjct: 700 TSLSTYQINHYTPQFEDHFPQSI---DVLESVPINTPLARLAATDPDAGFNGKLVYVIAD 756
Query: 933 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
F++E ++G + L+ E T + L V +D G P SS + + V
Sbjct: 757 GN---EEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDW 813
Query: 993 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1047
+ PRF Y+ +SE GT + ++ + N + Y+++S E+ F ++
Sbjct: 814 NDNAPRFPPGGYQ-LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHP 870
Query: 1048 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS----NTAKVYIEIQDENNH 1103
+TG + V G LD E+ Y+L+V+A PSK + + I ++D N++
Sbjct: 871 LTGELVVTGHLDRESEPRYILKVEARD---------QPSKGHQLFSVTDLIITLEDVNDN 921
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVET 1162
P + V ED T + + A+D D G + Y L+ +G G F V+
Sbjct: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLM-----DGAHGTFRVDL 976
Query: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK----ADVLVSVVNQ 1208
TG + RR+ + + A+D G+ L+ + +V+V VN+
Sbjct: 977 MTGALILERELDFERRAGYNLSLWASDG-GRPLARRTLCHVEVIVLDVNE 1025
Score = 127 bits (319), Expect = 1e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 717 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 776
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Query: 777 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 836
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
Query: 837 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 895
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
Query: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 955
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
Query: 956 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1012
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
Query: 1013 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1072
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
Query: 1073 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
Query: 1133 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1189
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
Score = 77.0 bits (188), Expect = 2e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 610 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 659
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
Query: 660 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 719
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 720 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 776
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
Query: 777 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 821
S V T +TY TVLV+ N +G + +E D G
Sbjct: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
Query: 822 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 881
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
Query: 882 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 937
+ P F +I + P + + V + PPG VR V +
Sbjct: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
Query: 938 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 988
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
Query: 989 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1044
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
Query: 1045 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
Query: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
Query: 1164 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1216
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 268 bits (685), Expect = 4e-71
Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)
Query: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417
F MP+YQ + E+ P G I L L + I ++ + + Y + +
Sbjct: 245 FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 475
T T + +DRE ++T+ + A D S + + V D ND++P F +
Sbjct: 302 TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
Query: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 535
Y V ++ G V+ + A D D N + Y +L GA F +N+++G+++ ++
Sbjct: 357 EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
Query: 536 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 595
Y L V+A D ++ TVYIEV N + P+F + Y +++ E + +
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
Query: 596 AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 652
+L +QATDR+ +I Y+I +G+ F L +GIL + LD E +Y L I
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 653 ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 709
A DG P S+ V++ V DVNDN P+F P +V+E + V ++A D D+
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
Query: 710 GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 749
G N ++HY L + + F S+G I +L+RE ++Y
Sbjct: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
Query: 750 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 809
V A D P S+ +++I VLD++DN PVFT TY + + E+ G+++L ++A+D
Sbjct: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
Query: 810 DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 867
D + ++Y++ ++ FAL G ++L LDY+ QE V A D GT
Sbjct: 715 DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
Query: 868 MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 927
A V + V D N + PVF Y V+ D GT I T+ A D D +R+
Sbjct: 769 R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
Query: 928 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 987
Y + D P F ++ DSG + T + L+ E + L ++A D+G P S + T++I
Sbjct: 826 YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
Query: 988 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1041
L+L + P+F + Y+ + E A T + +SA + N ++Y+ G++ D
Sbjct: 881 LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1100
F I +GVI LD E Y +L + + P+ S + ++ + I D
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1158
N++ P+F+K V E+ + + V +++A D D G + + Y+++ EG + F
Sbjct: 993 NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
Query: 1159 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
++ G ++ + L +RR Y V+ L +A V + +V+Q D
Sbjct: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
Score = 252 bits (644), Expect = 2e-66
Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)
Query: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 359
+F + T +S ++R+ + L +KA + P A + + + D N+ SP F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 360 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419
Y+ + E+ VG + L I A D+D + + L VF + +
Sbjct: 355 QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
Query: 420 -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 474
+G+ +L DREE Y + A D + P+ V I+V D NDN P F E
Sbjct: 405 SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
Query: 475 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 533
+Y V V D+ +V+++ A D D+G N I Y IL G G F ++ +G++ +
Sbjct: 462 QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
Query: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
++ + Y+L+++A D P NS V ++VL N+ + P F + + E +
Sbjct: 522 LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
Query: 594 VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 633
+G ++++QA D + D+ + + G P F + ++G +
Sbjct: 580 LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
Query: 634 TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 691
T+ LDRE + Y + A D G P +S+ +V+I V DVNDN PVF P L+
Sbjct: 640 TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
Query: 692 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 746
+ + V ++A D DA N + Y L GN N F ++S G I A+ L+ +
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
Query: 747 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 806
Y L V A+DG R T + I V D + + PVF +S YTV V E+ P GT+I + A
Sbjct: 757 QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
Query: 807 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 864
D D G N ++Y I+ P + F + P +G + + LDYE + + T + A D
Sbjct: 814 NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
Query: 865 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924
T+ +++ D ND P F Y+G + DA T I V A D D P
Sbjct: 868 GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
Query: 925 RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 980
R+ Y DD F +E SG + T+ L+ E ++ L +A D G P +S
Sbjct: 926 RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
Query: 981 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1035
+S +++ +L + P F ++E V E G++V I A N I+Y IV
Sbjct: 981 ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
Query: 1036 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1095
G+ F ++ + G + LD+E R YVL VQA S +V + A V+I
Sbjct: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
Query: 1096 EIQDENNHPPV 1106
+ D+N++PPV
Sbjct: 1090 LLVDQNDNPPV 1100
Score = 250 bits (639), Expect = 8e-66
Identities = 239/845 (28%), Positives = 376/845 (44%), Gaps = 104/845 (12%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST VLDR+ V V Y + ++V+D ND+SP F+ Y V
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD 217
E VG + T A+D D N + Y + D LNE +T
Sbjct: 364 ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGGAWD---VFQLNESSGVVSTRA-- 413
Query: 218 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAI-----------PE-------LRTPEELN 259
VLD ++ L R+ PL+ A + P+ ++ PE++
Sbjct: 414 VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
Query: 260 PIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD 319
+QA D+D+ I YSIL G F++H + L ++ P++ +
Sbjct: 474 LNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ---FYLHSLSGILDVINPLDFE 525
Query: 320 FHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378
QK+ L IKA+ PL +G + +++LD N+ P F +Q +LE+ P+G +
Sbjct: 526 DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV- 584
Query: 379 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT-----------------G 421
+ I A+D D ++ LH L D S F +
Sbjct: 585 --------VHIQAVDAD--SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHN 634
Query: 422 ITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDV 479
+ ++T+ +DREE + Y+F + A D S V+I V+D NDN P F + +Y++
Sbjct: 635 SSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYEL 694
Query: 480 YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEM 536
+ D G SV+ L A D D +N ITY++ G + F ++ + GLIT+A ++
Sbjct: 695 RLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
Query: 537 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 596
+ Y L V A+D R+ V I V N P F Y++ +SE VG
Sbjct: 753 KQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV-FQSSHYTVSVSEDRPVGT 806
Query: 597 VLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 653
+ L A D E ITY I++ PQ F + +G + LD E+ Y L I A
Sbjct: 807 SIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 654 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712
D G P + T T+ I++ D NDNAP F + + + + QV ATD D+G N
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 713 GQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLT 767
G++ Y+ + + ++G I T +L+RE Y L +A D G+ P +++
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVE 984
Query: 768 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 825
+ + +LDI+DN+P+F + VEEN P G+ + +I A D D G N + Y+I +++
Sbjct: 985 IQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMR 1044
Query: 826 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--ATVTVIVKDMN 883
HFF L G+L + LD+E +V+A T P + ATV +++ D N
Sbjct: 1045 HFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA-----TSAPLVSRATVHILLVDQN 1095
Query: 884 DYPPV 888
D PPV
Sbjct: 1096 DNPPV 1100
Score = 211 bits (538), Expect = 4e-54
Identities = 230/852 (26%), Positives = 361/852 (42%), Gaps = 126/852 (14%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156
ST VLDR+ + ++V+ + G + V I V D NDN P F ++Y V
Sbjct: 410 STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------------------YNPDD 197
E + T + ATD D G N I Y I NP D
Sbjct: 469 PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLD 523
Query: 198 PDRAQNLN-----------ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQ 246
+ Q + ++ ++V VLD +D P+F+ + PL Y
Sbjct: 524 FEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY- 582
Query: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT------------- 293
P++ IQA+D D S L+ LV T
Sbjct: 583 -------------PVV---HIQAVDAD------SGENARLHYRLVDTASTFLGGGSAGPK 620
Query: 294 -PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 351
P P F F +H + +++ ++R+ + + ++A P+ + + I +LD
Sbjct: 621 NPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDV 680
Query: 352 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 411
N+ P FT P+Y+ + E A VG+++ L + A D+D L +
Sbjct: 681 NDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV--ITYQLTGGNT 729
Query: 412 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471
+ F ++ +TL P+D +++Q Y ++TA DG + S V I V DAN + P
Sbjct: 730 RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTDANTHRPV 788
Query: 472 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIA 531
F Y V V D G S+ L+A D D G N ITY ++ F I+ +G +
Sbjct: 789 FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTM 847
Query: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
++ Y LT+ A DN P +++ T+ I +L N+ + P+F Y I E
Sbjct: 848 MELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLWDFYQGSIFED 904
Query: 592 MRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRY 647
+L + ATDR+ + Y + GD F + T+G++ + LDRE+ Y
Sbjct: 905 APPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVY 964
Query: 648 ILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN---AFVGQV 702
L A D G P S + + + + D+NDNAP+F+ L + EE N + V ++
Sbjct: 965 NLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEENNPVGSVVAKI 1021
Query: 703 KATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAV 759
+A DPD G N Q+ Y + G+ + F++ NG + V+L+ EVR Y LVV AT
Sbjct: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA-- 1079
Query: 760 HPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQIEAKDVDLGAN 814
P S T+ I ++D +DN PV + + Y + P G I I A D D+ +
Sbjct: 1080 -PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDS 1137
Query: 815 VSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVEAFDIYGTMPP 870
++Y L P TGEL L R LD EA E S++ + + + T+
Sbjct: 1138 LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIHSVTAFCTL-- 1193
Query: 871 GIATVTVIVKDM 882
VT+I DM
Sbjct: 1194 ---RVTIITDDM 1202
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 221 bits (562), Expect = 7e-57
Identities = 249/939 (26%), Positives = 395/939 (42%), Gaps = 123/939 (13%)
Query: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 360
FH+HP T + ++R+ + V L A + I + D N+ SP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 361 PSYQGYILESAPVGATI--------SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT 412
S Q + E +P G L T +V +D P L
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 413 SVFTVTQTGITR-----YLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDA 465
+ + G + L LL+ +DREE + I A+DG + + + V ++V+D
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 466 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV----------GA 515
NDN P F + Y V D +PG V ++ A D D G NG + Y + GA
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 516 QGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 572
GD F + + +G++ + ++ + L V+A D AE + V I VL N
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVRVSIAVLDVN 407
Query: 573 NQSPPRFPQLMYS---LEISEAMRVGAVLLNLQATDREGD------------------SI 611
+ P + +SE R G + + +D +GD SI
Sbjct: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
Query: 612 TYAIENGDPQRVFNLSETTGI--LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 668
+ ++E G+ G+ L + LDRES D Y L++ A+D G P ++ T+ +
Sbjct: 468 SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL 527
Query: 669 VVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG-----------INGQVH 716
V D+ND P+F SV E A V V A+D D +
Sbjct: 528 RVADLNDQPPLFSQQ-HYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
Query: 717 YSLGNFNN----------LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
+LG+ + F I S +G+I T L+REV++ EL VVA D P +T
Sbjct: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
Query: 766 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI---- 819
++I V D++DN P+F Y + E+ P G LQ+ A D D G + Y +
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 820 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 879
S E F + P G++ + + +D E P A+ LVEA D G A V V +
Sbjct: 707 LSYEAPQAFRIDPHDGQICVSQDIDRERDP---ATYDLLVEAKDGGGLSAQ--AFVRVDL 761
Query: 880 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 939
+D+ND PVF+ Y ++ + GT I V A D D G+ + V Y + +
Sbjct: 762 EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD-SGIYGT-VAYELIPGNV---S 816
Query: 940 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSSATVKIL--VLHPGEI 995
S+F ++ +G + + L+ +T L+V A D G V+++ T+ I L P E
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 996 --PRFTQEEYRPPPVSELATKGTMVGVISA-AAINQS--IVYSIVSGNEEDTFGINNITG 1050
P++T Y P + + +G + A +N S I Y I SG+ F I+ G
Sbjct: 877 ERPKYTFLVYEDVP------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
Query: 1051 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1110
I PLD+ET+ VL VQ A L ++ +V I + D N++ P F +
Sbjct: 931 TIRTRKPLDHETQPVVVLTVQ--------AQLGSAPACSSTEVNITVMDVNDNHPAFLRT 982
Query: 1111 FYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1149
+S+ T++ +A D+D+G ++ Y + P
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
Score = 189 bits (480), Expect = 2e-47
Identities = 208/764 (27%), Positives = 312/764 (40%), Gaps = 80/764 (10%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ + VV + V I V D NDN P F + Y AT+
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI-------------QYNPDDPDR--AQ 202
E PVG A+D D G G IEY + + +P D +Q
Sbjct: 674 EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQ 728
Query: 203 NLN-ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPL----TYQAAIPELRTPEE 257
+++ ER T L V+ DG L V + + D P+ TY +I + E
Sbjct: 729 DIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD-----E 783
Query: 258 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 317
P + A DQD I + Y ++ P + F + T + L P++
Sbjct: 784 TQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSSLFTIDSTTGIIYLTLPLS 835
Query: 318 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 377
L++ A+ G A + I I F P Y + E P
Sbjct: 836 HLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED--- 892
Query: 378 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREE 436
SP+ V + + ++ + D F++ + G R +P+D E
Sbjct: 893 -------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHET 942
Query: 437 QQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 495
Q ++ A G + VNI VMD NDN P F S ++ + PG ++
Sbjct: 943 QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 1002
Query: 496 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
A D D G NG I Y I G F I++ G++ + + R LT++A D
Sbjct: 1003 AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP 1062
Query: 556 ERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDS 610
+ + TV IE SP F L+Y +E+SE++ +L QA R
Sbjct: 1063 QAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
Query: 611 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVN 667
+ Y++E +F + TG + L + D EST Y + A DG ST TV
Sbjct: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVI 1178
Query: 668 IVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNN 724
+ V D NDN+P F L L + EE+ +G++ A D D+G NGQ+ Y L +
Sbjct: 1179 VRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK 1235
Query: 725 LFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF- 782
F++ N G + V L+RE R ++E+ V+ TD PR++T+ + + V DI+DN P F
Sbjct: 1236 FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 1295
Query: 783 ---TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRS 821
V V E P + + AKD D G A V+Y + S
Sbjct: 1296 QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 184 bits (468), Expect = 5e-46
Identities = 282/1190 (23%), Positives = 461/1190 (38%), Gaps = 157/1190 (13%)
Query: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 176
+G ++ E+R V D ND+SP F +S V+EL+P GT + D A
Sbjct: 147 LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204
Query: 177 -----TDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPC 231
+D+ P G + ++Y P + L + L + +L D
Sbjct: 205 TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHR 263
Query: 232 VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG------- 284
+ + RP ELR +E + PP+ D+ R +PG
Sbjct: 264 LQIEAWDGGRPRRTGLLSVELRVLDEND----NPPVFEQDEYRAAVREDAQPGAEVCRVR 319
Query: 285 -----------ILYSILV---------GTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
+ YS+ G +F + + + + P++R+
Sbjct: 320 ATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWH 379
Query: 325 DLVIKAEQDNGHPLPAFAGLHIEILDENNQSP----YFTMPSYQGYILESAPVGATISDS 380
LV++A P A + I +LD N+ P F + E A G ++
Sbjct: 380 QLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVA-- 437
Query: 381 LNLTSPLRIVALDKDIEDTKDPE-------------LHLFLNDYTSVFTVTQTGI--TRY 425
R+ D D + K+ E + L L F + G +
Sbjct: 438 -------RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFF 490
Query: 426 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L + P+DRE + Y + A D S + ++V D ND P F + Y V
Sbjct: 491 LCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSE 550
Query: 484 DMRPGDSVIQLTAVDADEGSN------------------GEITYEILVGAQ--GDFIINK 523
PG V+ ++A DADE + G + +++ A+ F I+
Sbjct: 551 AAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDS 610
Query: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
+G I+ ++ V L V A D P ++ C V I V N + P F + +
Sbjct: 611 ESGAISTIRTLDREVQEAVELKVVAQDLGEPP--LSATCLVSITV-DDVNDNEPIFWRQV 667
Query: 584 YSLEISEAMRVGAVLLNLQATDREG---DSITYAIENG----DPQRVFNLSETTGILTLG 636
Y+ I+E VG L + A+D + I Y++ +G + + F + G + +
Sbjct: 668 YNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS 727
Query: 637 KALDRE-STDRYILIITASDGRPDGTST-ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 694
+ +DRE Y L++ A DG G S A V + + DVNDN PVF+P E +
Sbjct: 728 QDIDRERDPATYDLLVEAKDG--GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQ 785
Query: 695 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 751
+ V ATD D+GI G V Y L GN ++LF I S G IY + L+ L+
Sbjct: 786 PGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLM 845
Query: 752 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VD 810
V A DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 846 VSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLN 905
Query: 811 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 870
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P
Sbjct: 906 SSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQA--QLGSAPA 959
Query: 871 GIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVR 927
+T V + V D+ND P F + + ++ GT + AED D GL +R
Sbjct: 960 CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IR 1015
Query: 928 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 987
Y + Q +F ++ G + +L L + A D G ++ + +
Sbjct: 1016 YSIASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 1071
Query: 988 LVLHPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1038
++ P +T E E P L T+ +G AA+ + YS+
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSV 1128
Query: 1039 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEI 1097
+ FGI TG IY+ DYE+ +Y RV A E L N+ + V + +
Sbjct: 1129 DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRV 1181
Query: 1098 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1157
DEN++ P F V E + ++ A D D+G + Y L + +GK
Sbjct: 1182 WDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL----LSDGK-F 1236
Query: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1207
F + TG + + R + + V+ TD + V VSV +
Sbjct: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
Score = 175 bits (444), Expect = 3e-43
Identities = 265/1112 (23%), Positives = 445/1112 (40%), Gaps = 158/1112 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F+ + Y A V E G + ATD D GPNG + Y ++
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336
Query: 193 YNPDDP---------DRA--------------QNLNERRTTTTTLTVDVLDG--DDLGPM 227
D A + L+ L V+ DG +
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVAT 396
Query: 228 FLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG 284
+ V + D RP + + E R E P + D D + + + G
Sbjct: 397 VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
Query: 285 ILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 335
L SI L G D+ P L + P++R+ ++L++ A
Sbjct: 457 ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGS 516
Query: 336 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-----SDS---------- 380
PL L + + D N+Q P F+ Y+ + E+A G + SD+
Sbjct: 517 PPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWL 576
Query: 381 ----LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 436
+ L++P + +L + T + ++ + + +T +DRE
Sbjct: 577 RYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT-----------LDREV 625
Query: 437 QQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 494
Q+ + A D + S +V+I V D NDN P F Y+ + G +Q+
Sbjct: 626 QEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685
Query: 495 TAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQA 548
TA DAD G G I Y + G A F I+ G I ++ ++ TY L V+A
Sbjct: 686 TASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEA 745
Query: 549 ADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
D + + ++ V L N + P F Y IS+ + G ++N+ ATD++
Sbjct: 746 KDGGGLSAQ------AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD 799
Query: 608 G---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 664
++ Y + G+ +F + TTGI+ L L + L+++A DG G TA
Sbjct: 800 SGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDG---GGLTA 856
Query: 665 TVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVKATDPDAGINGQV 715
+N VT +F L P+ +V E+ ++ +G VKA +P + +
Sbjct: 857 VINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPI 910
Query: 716 HY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 772
Y S G+ F I G+I T L+ E + L V A G+ P S+ + I V
Sbjct: 911 FYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITV 969
Query: 773 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFAL 830
+D++DN P F ++ + + + P GT + A+D D G N + Y I SP+ FA+
Sbjct: 970 MDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAI 1028
Query: 831 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP--V 888
G L L SL ++ +T + A D G P V +V + ++ P
Sbjct: 1029 DRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWT 1083
Query: 889 FSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEE 946
F +Y+ V+ +P+T + A P P AS +RY ++ +++F +
Sbjct: 1084 FEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP---SVDSAMFGIRP 1137
Query: 947 DSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHPGE-IPRFTQE-- 1001
+G + R + E T + V A+ +DG + + S TV + V + P F +
Sbjct: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVL 1196
Query: 1002 ----EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1057
E P P + G + + + N ++Y ++S + F +N TG +
Sbjct: 1197 FLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGELINWVA 1251
Query: 1058 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFY 1112
LD E R + + V++ + P ++ T VY+ + D N++ P F K+ +
Sbjct: 1252 LDREHRGHH-------EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELH 1304
Query: 1113 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1144
+ V E + V V A D D GN + + Y
Sbjct: 1305 V-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Score = 147 bits (372), Expect = 7e-35
Identities = 185/746 (24%), Positives = 315/746 (42%), Gaps = 122/746 (16%)
Query: 594 VGAVLLNLQATDREGDSITYAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILI 650
VG + L A ++ S + E+ D + F++ TGI+ + LDRE D Y +
Sbjct: 83 VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFV 142
Query: 651 ITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDA 709
G + V I V DVND++P F L ++S + AF V A DPDA
Sbjct: 143 AATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPV-AHDPDA 196
Query: 710 GINGQVHYSLGNFNNL----------FRITSNGSIYTAV-----------------KLNR 742
G+ Y+L ++L R + G + + + +L+R
Sbjct: 197 GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDR 256
Query: 743 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802
E + L + A DG R L++ ++VLD +DN PVF Y V E+ G +
Sbjct: 257 EEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVC 316
Query: 803 QIEAKDVDLGAN--VSYRIRSPEV------------KHFFALHPFTGELSLLRSLDYEAF 848
++ A D DLG N V Y +R+ +V +FA+ +G + + R LD EA
Sbjct: 317 RVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREA- 375
Query: 849 PDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP----VFSKRIYKGMVAPDA 902
+A +VEA D G P +AT V++ V D+ND P +F V+ A
Sbjct: 376 ---QAWHQLVVEARD--GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430
Query: 903 VKGTPITTVYAEDADPP-------------GLPASRVRYRVDDVQFPY------PASIFE 943
G + V DAD GL + ++ + + P +F
Sbjct: 431 RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVF- 489
Query: 944 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1003
+ L+ E +++L++VA D G P +S+ T+ + V + P +++
Sbjct: 490 ------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
Query: 1004 RPPPVSELATKGTMVGVISAAAINQS------IVYSIVS-------GNEED--------- 1041
VSE A GT+V +SA+ +++ + Y++V G+ +
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
Query: 1042 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
+F I++ +G I LD E + +A L+VV +L P S T V I + D
Sbjct: 604 PSFAIDSESGAISTIRTLDREVQ-------EAVELKVVAQDLGEPPLSATCLVSITVDDV 656
Query: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK-EGKEGFV 1159
N++ P+F ++ Y ++E A + L+V A+D D+G Y + Y L + E + F
Sbjct: 657 NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 1160 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS-NV 1218
++ + G I + + R + ++ G GLS +A V V + + D + + +
Sbjct: 717 IDPHDGQICVSQDI-DRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 1219 PPTLVEKKIEDLTEILDRYVQEQIPG 1244
T + + + TEI++ +Q G
Sbjct: 776 YVTSISDETQPGTEIINVLATDQDSG 801
Score = 33.1 bits (74), Expect = 2.7
Identities = 26/70 (37%), Positives = 29/70 (41%), Gaps = 2/70 (2%)
Query: 1713 ISPPSPPPAP--APLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL 1770
+S SPP P+A PD FS PS P FF L T GP PL
Sbjct: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
Query: 1771 LPPFPTPLPP 1780
LP +PL P
Sbjct: 236 LPGSSSPLEP 245
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 426 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 484 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 539
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 540 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 598
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 599 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 655
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 656 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 712
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 713 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 771
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 772 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 831
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 832 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 889
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 890 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 945
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 946 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 977
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 581 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 631
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 632 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 677
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 678 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 732
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 733 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 788
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 789 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 843
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 903
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 904 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 953
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 954 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1013
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1014 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1069
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1070 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1130 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1190 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1240
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 4e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 312 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 369
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 370 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 424
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 425 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 478
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 479 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 530
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 531 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 590
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 591 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 650 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 703
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 704 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 763 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 817 YRIRSPEVKHFFALHPFTGELSL 839
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 7e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 516
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 517 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 625
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 626 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 684
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 685 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 736
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 737 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 796
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 797 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 856
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 857 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 915
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 916 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 975
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 976 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1026
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVI 1052
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 138 bits (348), Expect = 5e-32
Identities = 164/634 (25%), Positives = 277/634 (43%), Gaps = 69/634 (10%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELT--------PVGTTIFTGFSGD------NGAT 177
+++I+V+D NDN+P F ++ E T P T TGF+G NG +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 178 ----DIDDGPNGQ--IEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG--DDLGPMFL 229
DI + P G+ + ++Q QNL+ + T + + V DG +
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQ---------QNLDREQKDTYVMKIKVEDGGTPQKSSTAI 237
Query: 230 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
V V + D RP+ + + E+ PE N + T IQ D +I ++ I Y
Sbjct: 238 LQVTVSDVNDNRPVFKEGQV-EVHIPE--NAPVGTSVIQLHATDADIGSNAE---IRYIF 291
Query: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 349
R F ++ T +++ ++R+ + + A +G PA A + I +
Sbjct: 292 GAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--SDGSSTPARATVTINVT 349
Query: 350 DENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVALDKDIEDTKDPELH 405
D N+ P + YI+ +P+ T+ D +N T I DKD + + ++
Sbjct: 350 DVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALITVSDKDTD--VNGKVI 400
Query: 406 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVM 463
F+ L +D E + ++F I A D + S + +V +++
Sbjct: 401 CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE 460
Query: 464 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINK 523
D NDN P F + ++ V + R G + ++A D D G N +I Y++ A F +++
Sbjct: 461 DENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDR 519
Query: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
TG++T + + + TV A DN P S V + VL N+ S P+F
Sbjct: 520 KTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVTVLDENDNS-PKFTHNH 576
Query: 584 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALD 640
+ +SE + + + + TD E ++T +I N + F L +G++ + D
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFD 634
Query: 641 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDPYLPRNLSVVEEEA--N 696
RE Y + A+D G+P +STA V I V DVNDN+P V P + +V A
Sbjct: 635 REQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPG 694
Query: 697 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 728
+ V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 695 SVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 105 bits (261), Expect = 6e-22
Identities = 128/475 (26%), Positives = 195/475 (41%), Gaps = 67/475 (14%)
Query: 89 PVKQMLFL--NSTG-----RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRN 141
P + LF N+TG R LDR+ IH + V + T V I V D N
Sbjct: 297 PATKRLFALNNTTGLITVQRSLDREETA-IHKVTVLA---SDGSSTPARATVTINVTDVN 352
Query: 142 DNSPTFKHESYYATVN------ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
DN P + +N E PV T I +D D NG++ I+
Sbjct: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIAL-----ITVSDKDTDVNGKVICFIEREV 407
Query: 196 DDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 255
+A N+ T++L LD + V + + P Q A+ ++
Sbjct: 408 PFHLKAVYDNQYLLETSSL----LDYEGTKEFSFKIVASDSGK---PSLNQTALVRVKLE 460
Query: 256 EEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR-------------FF 301
+E NP I P+ + N +R G+ + + T ED + FF
Sbjct: 461 DENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGKNADIVYQLGPNASFF 515
Query: 302 HMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMP 361
+ +T L+ +R+ ++F + A + PL + A + + +LDEN+ SP FT
Sbjct: 516 DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHN 575
Query: 362 SYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTG 421
+Q ++ E+ P +T+ I D D + K L + LND + +G
Sbjct: 576 HFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI-LNDNDNFVLDPYSG 625
Query: 422 ITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMDANDNTPTF---PEIS 476
+ + DRE+Q +YTF + A DG Q S V I VMD NDN+P P +
Sbjct: 626 VIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI 530
V PG V ++ AVD D G N E+ Y I+ G +G F I+ TG IT+
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 426 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 484 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 539
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 540 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 598
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 599 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 655
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 656 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 712
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 713 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 771
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 772 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 831
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 832 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 889
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 890 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 945
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 946 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 977
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 581 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 631
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 632 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 677
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 678 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 732
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 733 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 788
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 789 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 843
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 903
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 904 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 953
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 954 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1013
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1014 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1069
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1070 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1129
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1130 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1190 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1240
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 4e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 312 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 369
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 370 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 424
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 425 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 478
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 479 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 530
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 531 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 590
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 591 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 650 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 703
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 704 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 763 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 816
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 817 YRIRSPEVKHFFALHPFTGELSL 839
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 7e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 516
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 517 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 625
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 626 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 684
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 685 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 736
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 737 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 796
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 797 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 856
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 857 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 915
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 916 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 975
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 976 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1026
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVI 1052
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 138 bits (348), Expect = 5e-32
Identities = 164/634 (25%), Positives = 277/634 (43%), Gaps = 69/634 (10%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELT--------PVGTTIFTGFSGD------NGAT 177
+++I+V+D NDN+P F ++ E T P T TGF+G NG +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 178 ----DIDDGPNGQ--IEYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDG--DDLGPMFL 229
DI + P G+ + ++Q QNL+ + T + + V DG +
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQ---------QNLDREQKDTYVMKIKVEDGGTPQKSSTAI 237
Query: 230 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
V V + D RP+ + + E+ PE N + T IQ D +I ++ I Y
Sbjct: 238 LQVTVSDVNDNRPVFKEGQV-EVHIPE--NAPVGTSVIQLHATDADIGSNAE---IRYIF 291
Query: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 349
R F ++ T +++ ++R+ + + A +G PA A + I +
Sbjct: 292 GAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--SDGSSTPARATVTINVT 349
Query: 350 DENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVALDKDIEDTKDPELH 405
D N+ P + YI+ +P+ T+ D +N T I DKD + + ++
Sbjct: 350 DVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALITVSDKDTD--VNGKVI 400
Query: 406 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--EPVIVNIQVM 463
F+ L +D E + ++F I A D + S + +V +++
Sbjct: 401 CFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE 460
Query: 464 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINK 523
D NDN P F + ++ V + R G + ++A D D G N +I Y++ A F +++
Sbjct: 461 DENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDR 519
Query: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
TG++T + + + TV A DN P S V + VL N+ S P+F
Sbjct: 520 KTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVTVLDENDNS-PKFTHNH 576
Query: 584 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALD 640
+ +SE + + + + TD E ++T +I N + F L +G++ + D
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFD 634
Query: 641 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDPYLPRNLSVVEEEA--N 696
RE Y + A+D G+P +STA V I V DVNDN+P V P + +V A
Sbjct: 635 REQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPG 694
Query: 697 AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 728
+ V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 695 SVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 105 bits (261), Expect = 6e-22
Identities = 128/475 (26%), Positives = 195/475 (41%), Gaps = 67/475 (14%)
Query: 89 PVKQMLFL--NSTG-----RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRN 141
P + LF N+TG R LDR+ IH + V + T V I V D N
Sbjct: 297 PATKRLFALNNTTGLITVQRSLDREETA-IHKVTVLA---SDGSSTPARATVTINVTDVN 352
Query: 142 DNSPTFKHESYYATVN------ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
DN P + +N E PV T I +D D NG++ I+
Sbjct: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIAL-----ITVSDKDTDVNGKVICFIEREV 407
Query: 196 DDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 255
+A N+ T++L LD + V + + P Q A+ ++
Sbjct: 408 PFHLKAVYDNQYLLETSSL----LDYEGTKEFSFKIVASDSGK---PSLNQTALVRVKLE 460
Query: 256 EEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR-------------FF 301
+E NP I P+ + N +R G+ + + T ED + FF
Sbjct: 461 DENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGKNADIVYQLGPNASFF 515
Query: 302 HMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMP 361
+ +T L+ +R+ ++F + A + PL + A + + +LDEN+ SP FT
Sbjct: 516 DLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHN 575
Query: 362 SYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTG 421
+Q ++ E+ P +T+ I D D + K L + LND + +G
Sbjct: 576 HFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI-LNDNDNFVLDPYSG 625
Query: 422 ITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMDANDNTPTF---PEIS 476
+ + DRE+Q +YTF + A DG Q S V I VMD NDN+P P +
Sbjct: 626 VIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 477 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI 530
V PG V ++ AVD D G N E+ Y I+ G +G F I+ TG IT+
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 208 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 262
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 263 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 322
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 323 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 382
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 383 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 442 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 499
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 500 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 610
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 611 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 667 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 724
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 725 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 783
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 843
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 900
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 901 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 960
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 961 PTTIFKLVVVAFDDGEP 977
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 516 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 568
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 569 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 622
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 623 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 681
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 682 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 727
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 846
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 904
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1017
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1018 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1075
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1076 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 640
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 641 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 694 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 744
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 804
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 805 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 860 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 913
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 914 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 972 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1026
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1206
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1207 NQLDMQVIVSNVPP 1220
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 157 bits (397), Expect = 9e-38
Identities = 186/750 (24%), Positives = 316/750 (42%), Gaps = 81/750 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY------------VIQYNPDDPD 199
+N P + I + ++ A D D G NG Y VI+ P+
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIE-TPEGDK 229
Query: 200 RAQ-----NLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Q L+ T + V V DG + V V +T D P+ + I E+
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-EV 288
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
PE N + T Q D +I + I +S R FH++ T +++
Sbjct: 289 SIPE--NAPVGTSVTQLHATDADI---GENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 372
EP++R+ L++ A +G +PA A + + + D N+ P + YI+
Sbjct: 344 KEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVNDNVPSIDI----RYIVNPVN 397
Query: 373 VGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY-LTLLQ 430
+S+++ L + + ++ + DKD + D+ F + ++ L
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRLRPVFSNQFLLENAA 454
Query: 431 PVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 488
+D E + Y + A D + ++ ++ I+V D NDN P F + V + + PG
Sbjct: 455 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 514
Query: 489 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
+++++A DAD G N EI Y + A +F +++ TG++T+ ++ Y T+ A
Sbjct: 515 IQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM-RVGAVLLNLQATDRE 607
DN P N TV++ ++ N+ SP F Y + E + R G V L
Sbjct: 575 KDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
GD+ + D F + TG++ + DRE + Y + A D GR +S+A V
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 667 NIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GN 721
I V DVNDN PVF PY L + V QV A D D G+N +V YS+ GN
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 722 FNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 780
+LF I G+I K + TD +H + +K D+
Sbjct: 752 TRDLFAIDQETGNITLMEKCD------------VTDLGLH------RVLVKANDLGQPDS 793
Query: 781 VFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
+F+ + V E++ T I ++ K ++
Sbjct: 794 LFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 208 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 262
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 263 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 322
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 323 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 382
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 383 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 442 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 499
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 500 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 610
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 611 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 667 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 724
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 725 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 783
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 843
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 900
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 901 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 960
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 961 PTTIFKLVVVAFDDGEP 977
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 516 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 568
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 569 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 622
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 623 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 681
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 682 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 727
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 846
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 904
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1017
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1018 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1075
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1076 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 640
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 641 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 694 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 744
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 804
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 805 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 860 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 913
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 914 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 972 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1026
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1206
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1207 NQLDMQVIVSNVPP 1220
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 157 bits (397), Expect = 9e-38
Identities = 186/750 (24%), Positives = 316/750 (42%), Gaps = 81/750 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY------------VIQYNPDDPD 199
+N P + I + ++ A D D G NG Y VI+ P+
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIE-TPEGDK 229
Query: 200 RAQ-----NLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Q L+ T + V V DG + V V +T D P+ + I E+
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-EV 288
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
PE N + T Q D +I + I +S R FH++ T +++
Sbjct: 289 SIPE--NAPVGTSVTQLHATDADI---GENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 372
EP++R+ L++ A +G +PA A + + + D N+ P + YI+
Sbjct: 344 KEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVNDNVPSIDI----RYIVNPVN 397
Query: 373 VGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY-LTLLQ 430
+S+++ L + + ++ + DKD + D+ F + ++ L
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRLRPVFSNQFLLENAA 454
Query: 431 PVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 488
+D E + Y + A D + ++ ++ I+V D NDN P F + V + + PG
Sbjct: 455 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 514
Query: 489 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
+++++A DAD G N EI Y + A +F +++ TG++T+ ++ Y T+ A
Sbjct: 515 IQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM-RVGAVLLNLQATDRE 607
DN P N TV++ ++ N+ SP F Y + E + R G V L
Sbjct: 575 KDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
GD+ + D F + TG++ + DRE + Y + A D GR +S+A V
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 667 NIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GN 721
I V DVNDN PVF PY L + V QV A D D G+N +V YS+ GN
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 722 FNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 780
+LF I G+I K + TD +H + +K D+
Sbjct: 752 TRDLFAIDQETGNITLMEKCD------------VTDLGLH------RVLVKANDLGQPDS 793
Query: 781 VFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
+F+ + V E++ T I ++ K ++
Sbjct: 794 LFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 198 bits (504), Expect = 4e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 208 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 262
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 14 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 73
Query: 263 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 322
+ Q + + D P L+ ED F R L + RD H
Sbjct: 74 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 127
Query: 323 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 382
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 128 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 180
Query: 383 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 181 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 237
Query: 442 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 499
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 238 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 297
Query: 500 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 298 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 357
Query: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 610
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 358 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413
Query: 611 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 414 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 473
Query: 667 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 724
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 474 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 532
Query: 725 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 783
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 533 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 592
Query: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 843
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 593 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 900
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 653 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 708
Query: 901 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 960
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 709 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 763
Query: 961 PTTIFKLVVVAFDDGEP 977
+ +++V A D G+P
Sbjct: 764 DLGLHRVLVKANDLGQP 780
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 144 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 202
Query: 516 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 568
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 260
Query: 569 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 622
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 261 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 623 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 681
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 378
Query: 682 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 727
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 379 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 439 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 846
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 904
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 553 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 606
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 607 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 659
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1017
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 660 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719
Query: 1018 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1075
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 720 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 779
Query: 1076 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
VV+ NL V A + E+ ++ PV
Sbjct: 780 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815
Score = 172 bits (436), Expect = 3e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 640
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 54 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 113
Query: 641 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 114 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 172
Query: 694 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 744
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 173 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 804
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 233 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 292
Query: 805 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 293 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 348
Query: 860 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 913
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 349 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406
Query: 914 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 407 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 459
Query: 972 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1026
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 460 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 518
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 519 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 570
Query: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 571 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630
Query: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1206
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 631 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 1207 NQLDMQVIVSNVPP 1220
+ D + + VPP
Sbjct: 686 DVNDNKPVFI-VPP 698
Score = 157 bits (397), Expect = 9e-38
Identities = 186/750 (24%), Positives = 316/750 (42%), Gaps = 81/750 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 107 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 161
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY------------VIQYNPDDPD 199
+N P + I + ++ A D D G NG Y VI+ P+
Sbjct: 162 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIE-TPEGDK 218
Query: 200 RAQ-----NLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Q L+ T + V V DG + V V +T D P+ + I E+
Sbjct: 219 MPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-EV 277
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
PE N + T Q D +I + I +S R FH++ T +++
Sbjct: 278 SIPE--NAPVGTSVTQLHATDADI---GENAKIHFSFSNLVSNIARRLFHLNATTGLITI 332
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 372
EP++R+ L++ A +G +PA A + + + D N+ P + YI+
Sbjct: 333 KEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVNDNVPSIDI----RYIVNPVN 386
Query: 373 VGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY-LTLLQ 430
+S+++ L + + ++ + DKD + D+ F + ++ L
Sbjct: 387 DTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHEIPFRLRPVFSNQFLLENAA 443
Query: 431 PVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 488
+D E + Y + A D + ++ ++ I+V D NDN P F + V + + PG
Sbjct: 444 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 503
Query: 489 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
+++++A DAD G N EI Y + A +F +++ TG++T+ ++ Y T+ A
Sbjct: 504 IQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 563
Query: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM-RVGAVLLNLQATDRE 607
DN P N TV++ ++ N+ SP F Y + E + R G V L
Sbjct: 564 KDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 620
Query: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 666
GD+ + D F + TG++ + DRE + Y + A D GR +S+A V
Sbjct: 621 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 680
Query: 667 NIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GN 721
I V DVNDN PVF PY L + V QV A D D G+N +V YS+ GN
Sbjct: 681 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 740
Query: 722 FNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 780
+LF I G+I K + TD +H + +K D+
Sbjct: 741 TRDLFAIDQETGNITLMEKCD------------VTDLGLH------RVLVKANDLGQPDS 782
Query: 781 VFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
+F+ + V E++ T I ++ K ++
Sbjct: 783 LFSVVIVNLFVNESVTNATLINELVRKSIE 812
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 216 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 270
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 271 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 330
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 331 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 390
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 391 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 449
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 450 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 507
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 508 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 564 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 615
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 616 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 674
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 675 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 732
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 733 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 907
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 908 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 967
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 968 VVVAFDDGEP 977
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 516 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 568
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 569 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 622
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 623 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 681
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 682 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 727
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 846
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 904
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1017
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1018 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1075
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1076 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 6e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 640
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 641 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 694 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 744
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 804
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 805 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 860 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 913
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 914 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 972 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1026
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1206
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1207 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1261
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1262 SLEDYT-------KCDLT 1272
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 152 bits (383), Expect = 4e-36
Identities = 189/756 (25%), Positives = 317/756 (41%), Gaps = 93/756 (12%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY------------VIQYNPDDPD 199
+N P + I + ++ A D D G NG Y VI+ P+
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIE-TPEGDK 197
Query: 200 RAQ-----NLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Q L+ T + V V DG + V V +T D P+ + I E+
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-EV 256
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
PE N + T Q D +I + I +S R FH++ T +++
Sbjct: 257 SIPE--NAPVGTSVTQLHATDADI---GENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 372
EP++R+ L++ A +G +PA A + + + D N+ P + YI+
Sbjct: 312 KEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVNDNVPSIDI----RYIVNPVN 365
Query: 373 VGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHLFLNDYTSVFTVTQTGITRY 425
+S+++ L + + ++ + DKD + D E+ L S + +T Y
Sbjct: 366 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLET--AAY 423
Query: 426 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L D E + Y + A D + ++ ++ I+V D NDN P F + V +
Sbjct: 424 L------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 477
Query: 484 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYA 543
+ PG + +++A+DAD G N +I Y + A +F ++ TG++T+ ++ Y
Sbjct: 478 NNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 544 LTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM-RVGAVLLNLQ 602
T+ A DN P N TV++ ++ N+ SP F Y+ + E + R G V L
Sbjct: 538 FTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYNFYVPENLPRHGTVGLITV 594
Query: 603 ATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 661
GD+ + D F + TG++ + DRE + Y + A D GR +
Sbjct: 595 TDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 662 STATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAFVGQVKATDPDAGINGQVHY 717
S+A V I V DVNDN PVF P N S + V QV A D D G+N +V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 718 SL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 774
S+ GN +LF I G+I K + TD +H + +K D
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH------RVLVKAND 755
Query: 775 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
+ +F+ + V E++ T I ++ K +
Sbjct: 756 LGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 216 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 270
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 271 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 330
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 331 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 390
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 391 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 449
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 450 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 507
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 508 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 564 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 615
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 616 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 674
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 675 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 732
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 733 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 907
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 908 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 967
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 968 VVVAFDDGEP 977
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 456 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 515
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 516 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 568
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 569 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 622
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 623 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 681
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 682 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 727
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 788 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 846
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 847 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 904
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 905 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 964
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 965 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1017
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1018 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1075
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1076 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 6e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 587 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 640
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 641 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 693
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 694 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 744
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 745 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 804
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 805 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 859
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 860 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 913
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 914 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 972 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1026
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1027 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1086
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1087 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1146
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1147 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1206
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1207 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1261
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1262 SLEDYT-------KCDLT 1272
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 152 bits (383), Expect = 4e-36
Identities = 189/756 (25%), Positives = 317/756 (41%), Gaps = 93/756 (12%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY------------VIQYNPDDPD 199
+N P + I + ++ A D D G NG Y VI+ P+
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIE-TPEGDK 197
Query: 200 RAQ-----NLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 252
Q L+ T + V V DG + V V +T D P+ + I E+
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-EV 256
Query: 253 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 312
PE N + T Q D +I + I +S R FH++ T +++
Sbjct: 257 SIPE--NAPVGTSVTQLHATDADI---GENAKIHFSFSNLVSNIARRLFHLNATTGLITI 311
Query: 313 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 372
EP++R+ L++ A +G +PA A + + + D N+ P + YI+
Sbjct: 312 KEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVNDNVPSIDI----RYIVNPVN 365
Query: 373 VGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHLFLNDYTSVFTVTQTGITRY 425
+S+++ L + + ++ + DKD + D E+ L S + +T Y
Sbjct: 366 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLET--AAY 423
Query: 426 LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYT 483
L D E + Y + A D + ++ ++ I+V D NDN P F + V +
Sbjct: 424 L------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPE 477
Query: 484 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYA 543
+ PG + +++A+DAD G N +I Y + A +F ++ TG++T+ ++ Y
Sbjct: 478 NNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 544 LTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM-RVGAVLLNLQ 602
T+ A DN P N TV++ ++ N+ SP F Y+ + E + R G V L
Sbjct: 538 FTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYNFYVPENLPRHGTVGLITV 594
Query: 603 ATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 661
GD+ + D F + TG++ + DRE + Y + A D GR +
Sbjct: 595 TDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 662 STATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAFVGQVKATDPDAGINGQVHY 717
S+A V I V DVNDN PVF P N S + V QV A D D G+N +V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 718 SL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 774
S+ GN +LF I G+I K + TD +H + +K D
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH------RVLVKAND 755
Query: 775 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 810
+ +F+ + V E++ T I ++ K +
Sbjct: 756 LGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,646,017
Number of Sequences: 37866
Number of extensions: 4878611
Number of successful extensions: 120787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 958
Number of HSP's successfully gapped in prelim test: 1182
Number of HSP's that attempted gapping in prelim test: 35274
Number of HSP's gapped (non-prelim): 38206
length of query: 1915
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1798
effective length of database: 13,817,196
effective search space: 24843318408
effective search space used: 24843318408
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.