Guide to the Human Genome
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Name: BACE2 Sequence: fasta or formatted (396aa) NCBI GI: 21040362
Description:

beta-site APP-cleaving enzyme 2 isoform B preproprotein

Referenced in:

Aspartic Proteases
Additional Brain Proteins

Other entries for this name:
alt prot [518aa] beta-site APP-cleaving enzyme 2 isoform A preproprotein
alt prot [468aa] beta-site APP-cleaving enzyme 2 isoform C preproprotein
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             9.6         38           3
 C cysteine            1.0          4           1
 D aspartate           4.0         16           1
 E glutamate           4.8         19           2
 F phenylalanine       5.1         20           2
 G glycine             8.6         34           2
 H histidine           0.5          2           1
 I isoleucine          5.3         21           1
 K lysine              3.5         14           1
 L leucine            12.1         48           3
 M methionine          1.5          6           1
 N asparagine          3.8         15           1
 P proline             6.8         27           2
 Q glutamine           4.0         16           2
 R arginine            3.8         15           1
 S serine              7.8         31           3
 T threonine           6.8         27           2
 V valine              5.3         21           2
 W tryptophan          2.0          8           1
 Y tyrosine            3.5         14           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   beta-site APP-cleaving enzyme 2 isoform B preproprot... 
BACE2                 0.953   beta-site APP-cleaving enzyme 2 isoform A preproprot...
BACE2                 0.816   beta-site APP-cleaving enzyme 2 isoform C preproprot...
BACE1                 0.452   beta-site APP-cleaving enzyme 1 isoform A preproprote...
BACE1                 0.390   beta-site APP-cleaving enzyme 1 isoform B preproprot...
BACE1                 0.364   beta-site APP-cleaving enzyme 1 isoform C preproprot...
BACE1                 0.212   beta-site APP-cleaving enzyme 1 isoform D preproprot...
PGC                   0.122   progastricsin (pepsinogen C) 
CTSD                  0.092   cathepsin D preproprotein 
CTSE                  0.092   cathepsin E isoform a preproprotein 
PGA4                  0.089   pepsinogen 4, group I 
PGA3                  0.089   pepsinogen 3, group I 
PGA5                  0.089   pepsinogen 5, group I 
REN                   0.087   renin preproprotein 
CTSE                  0.070   cathepsin E isoform b preproprotein 
NAPSA                 0.067   napsin A preproprotein 
FAM65A                0.010   hypothetical protein LOC79567 
WDR6                  0.010   WD repeat domain 6 protein 
IRS2                  0.010   insulin receptor substrate 2 
SYN1                  0.010   synapsin I isoform Ia 
SYN1                  0.010   synapsin I isoform Ib 
PKD1                  0.009   polycystin 1 isoform 2 precursor 
PKD1                  0.009   polycystin 1 isoform 1 precursor 
LOC100292865          0.009   PREDICTED: hypothetical protein 
SAMD1                 0.009   sterile alpha motif domain containing 1 
SEC16A                0.008   SEC16 homolog A 
TBC1D10B              0.008   TBC1 domain family, member 10B 
CDKN1C                0.006   cyclin-dependent kinase inhibitor 1C isoform b [Hom...
CDKN1C                0.006   cyclin-dependent kinase inhibitor 1C isoform b [Hom...
CDKN1C                0.006   cyclin-dependent kinase inhibitor 1C isoform a 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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