Guide to the Human Genome
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Name: BACE2 Sequence: fasta or formatted (468aa) NCBI GI: 21040360
Description:

beta-site APP-cleaving enzyme 2 isoform C preproprotein

Referenced in:

Aspartic Proteases
Additional Brain Proteins

Other entries for this name:
alt prot [518aa] beta-site APP-cleaving enzyme 2 isoform A preproprotein
alt prot [396aa] beta-site APP-cleaving enzyme 2 isoform B preproprotein
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine            10.9         51           3
 C cysteine            1.5          7           1
 D aspartate           3.8         18           1
 E glutamate           5.1         24           2
 F phenylalanine       4.5         21           2
 G glycine             8.5         40           2
 H histidine           0.6          3           1
 I isoleucine          5.6         26           1
 K lysine              2.8         13           1
 L leucine            11.8         55           4
 M methionine          1.9          9           2
 N asparagine          3.6         17           1
 P proline             6.6         31           2
 Q glutamine           3.0         14           1
 R arginine            4.3         20           2
 S serine              7.5         35           3
 T threonine           5.6         26           2
 V valine              7.3         34           2
 W tryptophan          1.5          7           1
 Y tyrosine            3.6         17           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   beta-site APP-cleaving enzyme 2 isoform C preproprot... 
BACE2                 0.975   beta-site APP-cleaving enzyme 2 isoform A preproprot...
BACE2                 0.695   beta-site APP-cleaving enzyme 2 isoform B preproprot...
BACE1                 0.376   beta-site APP-cleaving enzyme 1 isoform A preproprote...
BACE1                 0.323   beta-site APP-cleaving enzyme 1 isoform B preproprot...
BACE1                 0.301   beta-site APP-cleaving enzyme 1 isoform C preproprot...
BACE1                 0.172   beta-site APP-cleaving enzyme 1 isoform D preproprot...
PGC                   0.108   progastricsin (pepsinogen C) 
CTSD                  0.086   cathepsin D preproprotein 
REN                   0.083   renin preproprotein 
CTSE                  0.082   cathepsin E isoform a preproprotein 
PGA4                  0.078   pepsinogen 4, group I 
PGA3                  0.078   pepsinogen 3, group I 
PGA5                  0.078   pepsinogen 5, group I 
CTSE                  0.060   cathepsin E isoform b preproprotein 
NAPSA                 0.058   napsin A preproprotein 
PTPRF                 0.010   protein tyrosine phosphatase, receptor type, F isof...
PTPRF                 0.010   protein tyrosine phosphatase, receptor type, F isof...
FAM65A                0.009   hypothetical protein LOC79567 
WDR6                  0.009   WD repeat domain 6 protein 
IRS2                  0.009   insulin receptor substrate 2 
SYN1                  0.009   synapsin I isoform Ia 
SYN1                  0.009   synapsin I isoform Ib 
PKD1                  0.008   polycystin 1 isoform 2 precursor 
PKD1                  0.008   polycystin 1 isoform 1 precursor 
LOC100292865          0.008   PREDICTED: hypothetical protein 
SAMD1                 0.008   sterile alpha motif domain containing 1 
SEC16A                0.007   SEC16 homolog A 
TBC1D10B              0.007   TBC1 domain family, member 10B 
CDKN1C                0.006   cyclin-dependent kinase inhibitor 1C isoform b [Hom...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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