Guide to the Human Genome
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Name: BACE1 Sequence: fasta or formatted (457aa) NCBI GI: 21040364
Description:

beta-site APP-cleaving enzyme 1 isoform C preproprotein

Referenced in:

Aspartic Proteases
Additional Brain Proteins

Other entries for this name:
alt prot [476aa] beta-site APP-cleaving enzyme 1 isoform B preproprotein
alt prot [432aa] beta-site APP-cleaving enzyme 1 isoform D preproprotein
alt prot [501aa] beta-site APP-cleaving enzyme 1 isoform A preproprotein
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.1         28           2
 C cysteine            2.4         11           1
 D aspartate           5.7         26           2
 E glutamate           5.5         25           2
 F phenylalanine       4.4         20           2
 G glycine             8.5         39           2
 H histidine           2.0          9           1
 I isoleucine          4.8         22           2
 K lysine              3.3         15           2
 L leucine            10.3         47           3
 M methionine          3.1         14           1
 N asparagine          2.4         11           1
 P proline             5.7         26           2
 Q glutamine           4.8         22           2
 R arginine            5.3         24           2
 S serine              6.6         30           2
 T threonine           5.7         26           2
 V valine              7.4         34           2
 W tryptophan          2.0          9           1
 Y tyrosine            4.2         19           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   beta-site APP-cleaving enzyme 1 isoform C preproprot... 
BACE1                 0.977   beta-site APP-cleaving enzyme 1 isoform A preproprote...
BACE1                 0.929   beta-site APP-cleaving enzyme 1 isoform D preproprot...
BACE1                 0.927   beta-site APP-cleaving enzyme 1 isoform B preproprot...
BACE2                 0.393   beta-site APP-cleaving enzyme 2 isoform A preproprot...
BACE2                 0.306   beta-site APP-cleaving enzyme 2 isoform B preproprot...
BACE2                 0.285   beta-site APP-cleaving enzyme 2 isoform C preproprot...
CTSE                  0.055   cathepsin E isoform a preproprotein 
CTSD                  0.053   cathepsin D preproprotein 
PGC                   0.053   progastricsin (pepsinogen C) 
PGA4                  0.051   pepsinogen 4, group I 
PGA3                  0.051   pepsinogen 3, group I 
PGA5                  0.050   pepsinogen 5, group I 
CTSE                  0.037   cathepsin E isoform b preproprotein 
REN                   0.036   renin preproprotein 
NAPSA                 0.027   napsin A preproprotein 
RPRD2                 0.013   Regulation of nuclear pre-mRNA domain containing 2 ...
ZNF385A               0.012   zinc finger protein 385A isoform b 
NSL1                  0.009   NSL1, MIND kinetochore complex component isoform 2 ...
NSL1                  0.009   NSL1, MIND kinetochore complex component isoform 1 ...
HS3ST3A1              0.007   heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3...
ZNF385A               0.005   zinc finger protein 385A isoform a 
ZNF385A               0.005   zinc finger protein 385A isoform c 
C2orf3                0.005   hypothetical protein LOC6936 
FAM134B               0.005   hypothetical protein LOC54463 isoform 1 
ASB15                 0.004   ankyrin repeat and SOCS box-containing 15 
FLJ23834              0.004   hypothetical protein LOC222256 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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