Guide to the Human Genome
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Name: BACE1 Sequence: fasta or formatted (501aa) NCBI GI: 6912266
Description:

beta-site APP-cleaving enzyme 1 isoform A preproprotein

Referenced in:

Aspartic Proteases
Additional Brain Proteins

Other entries for this name:
alt prot [457aa] beta-site APP-cleaving enzyme 1 isoform C preproprotein
alt prot [476aa] beta-site APP-cleaving enzyme 1 isoform B preproprotein
alt prot [432aa] beta-site APP-cleaving enzyme 1 isoform D preproprotein
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.8         34           2
 C cysteine            2.2         11           1
 D aspartate           5.4         27           2
 E glutamate           5.6         28           2
 F phenylalanine       4.4         22           2
 G glycine             8.6         43           2
 H histidine           2.0         10           1
 I isoleucine          5.6         28           2
 K lysine              3.2         16           2
 L leucine             9.8         49           3
 M methionine          2.8         14           1
 N asparagine          3.0         15           1
 P proline             5.6         28           2
 Q glutamine           4.4         22           2
 R arginine            5.2         26           2
 S serine              6.6         33           2
 T threonine           5.6         28           2
 V valine              7.4         37           2
 W tryptophan          2.0         10           1
 Y tyrosine            4.0         20           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   beta-site APP-cleaving enzyme 1 isoform A preproprote... 
BACE1                 0.935   beta-site APP-cleaving enzyme 1 isoform B preproprot...
BACE1                 0.892   beta-site APP-cleaving enzyme 1 isoform C preproprot...
BACE1                 0.565   beta-site APP-cleaving enzyme 1 isoform D preproprot...
BACE2                 0.425   beta-site APP-cleaving enzyme 2 isoform A preproprot...
BACE2                 0.348   beta-site APP-cleaving enzyme 2 isoform B preproprot...
BACE2                 0.328   beta-site APP-cleaving enzyme 2 isoform C preproprot...
CTSE                  0.079   cathepsin E isoform a preproprotein 
CTSD                  0.076   cathepsin D preproprotein 
PGA4                  0.072   pepsinogen 4, group I 
PGA3                  0.072   pepsinogen 3, group I 
PGA5                  0.072   pepsinogen 5, group I 
PGC                   0.065   progastricsin (pepsinogen C) 
CTSE                  0.064   cathepsin E isoform b preproprotein 
REN                   0.058   renin preproprotein 
NAPSA                 0.041   napsin A preproprotein 
ZNF385A               0.011   zinc finger protein 385A isoform b 
NSL1                  0.008   NSL1, MIND kinetochore complex component isoform 2 ...
NSL1                  0.008   NSL1, MIND kinetochore complex component isoform 1 ...
RPRD2                 0.006   Regulation of nuclear pre-mRNA domain containing 2 ...
HS3ST3A1              0.006   heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3...
ZNF385A               0.005   zinc finger protein 385A isoform a 
ZNF385A               0.005   zinc finger protein 385A isoform c 
C2orf3                0.005   hypothetical protein LOC6936 
FAM134B               0.005   hypothetical protein LOC54463 isoform 1 
ASB15                 0.004   ankyrin repeat and SOCS box-containing 15 
FLJ23834              0.004   hypothetical protein LOC222256 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
KCNJ15                0.004   potassium inwardly-rectifying channel J15 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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