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Search of human proteins with 21040360
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21040360 beta-site APP-cleaving enzyme 2 isoform C
preproprotein [Homo sapiens]
(468 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 932 0.0
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 909 0.0
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 655 0.0
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 366 e-101
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 318 7e-87
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 298 7e-81
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 181 2e-45
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 123 4e-28
gi|4503143 cathepsin D preproprotein [Homo sapiens] 103 3e-22
gi|4506475 renin preproprotein [Homo sapiens] 100 2e-21
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 99 1e-20
gi|119372302 pepsinogen 4, group I [Homo sapiens] 96 7e-20
gi|119372298 pepsinogen 3, group I [Homo sapiens] 96 7e-20
gi|23943854 pepsinogen 5, group I [Homo sapiens] 96 7e-20
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 79 7e-15
gi|4758754 napsin A preproprotein [Homo sapiens] 78 2e-14
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 34 0.33
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 34 0.33
gi|39995080 hypothetical protein LOC79567 [Homo sapiens] 33 0.55
gi|197927448 WD repeat domain 6 protein [Homo sapiens] 33 0.55
gi|38683860 insulin receptor substrate 2 [Homo sapiens] 33 0.72
gi|19924099 synapsin I isoform Ia [Homo sapiens] 33 0.72
gi|19924097 synapsin I isoform Ib [Homo sapiens] 33 0.72
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 32 0.95
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 32 0.95
gi|239753114 PREDICTED: hypothetical protein [Homo sapiens] 32 1.2
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 32 1.2
gi|124378039 SEC16 homolog A [Homo sapiens] 31 2.1
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 31 2.1
gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Hom... 30 4.7
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 932 bits (2410), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGAT 360
IVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGAT
Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGAT 360
Query: 361 VMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWI 420
VMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWI
Sbjct: 361 VMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWI 420
Query: 421 VSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK 468
VSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Sbjct: 421 VSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK 468
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 909 bits (2349), Expect = 0.0
Identities = 468/518 (90%), Positives = 468/518 (90%), Gaps = 50/518 (9%)
Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASL-------------------------------- 328
IVDSGTTLLRLPQKVFDAVVEAVARASL
Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI 360
Query: 329 ------------------LYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD 370
LYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
Sbjct: 361 YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD 420
Query: 371 RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG 430
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
Sbjct: 421 RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG 480
Query: 431 AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK 468
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Sbjct: 481 AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK 518
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 655 bits (1691), Expect = 0.0
Identities = 328/329 (99%), Positives = 329/329 (100%)
Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60
Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120
Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180
Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240
Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300
Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLL 329
IVDSGTTLLRLPQKVFDAVVEAVARASL+
Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLI 329
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 366 bits (939), Expect = e-101
Identities = 193/448 (43%), Positives = 267/448 (59%), Gaps = 57/448 (12%)
Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
W GILGLAYA +A+P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG
Sbjct: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 233
Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 234 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 293
Query: 308 LLRLPQKVFDAVVEAVARASLL-------------------------------------- 329
LRLP+KVF+A V+++ AS
Sbjct: 294 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 353
Query: 330 ------------YIQPMMGAGLNY-ECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRV 376
Y++P+ + +CY+F IS S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 354 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 413
Query: 377 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 436
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 414 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 472
Query: 437 IVLLLLPFRCQR--RPRDPEVVNDESSL 462
+ L++ +RC R R + + +D S L
Sbjct: 473 LCLMVCQWRCLRCLRQQHDDFADDISLL 500
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 318 bits (815), Expect = 7e-87
Identities = 177/448 (39%), Positives = 247/448 (55%), Gaps = 82/448 (18%)
Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
W GILGLAYA +A+ +CGAG P+ S + GG
Sbjct: 174 SNWEGILGLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGG 208
Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 209 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 268
Query: 308 LLRLPQKVFDAVVEAVARASLL-------------------------------------- 329
LRLP+KVF+A V+++ AS
Sbjct: 269 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 328
Query: 330 ------------YIQPMMGAGLNY-ECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRV 376
Y++P+ + +CY+F IS S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 329 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 388
Query: 377 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 436
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 389 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 447
Query: 437 IVLLLLPFRCQR--RPRDPEVVNDESSL 462
+ L++ +RC R R + + +D S L
Sbjct: 448 LCLMVCQWRCLRCLRQQHDDFADDISLL 475
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 298 bits (763), Expect = 7e-81
Identities = 169/448 (37%), Positives = 237/448 (52%), Gaps = 101/448 (22%)
Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
+ SSTYR V V YTQG W G +G DL
Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDL---------------------------- 145
Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG
Sbjct: 146 ----------------PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 189
Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 190 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 249
Query: 308 LLRLPQKVFDAVVEAVARASLL-------------------------------------- 329
LRLP+KVF+A V+++ AS
Sbjct: 250 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 309
Query: 330 ------------YIQPMMGAGLNY-ECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRV 376
Y++P+ + +CY+F IS S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 310 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 369
Query: 377 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 436
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 370 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 428
Query: 437 IVLLLLPFRCQR--RPRDPEVVNDESSL 462
+ L++ +RC R R + + +D S L
Sbjct: 429 LCLMVCQWRCLRCLRQQHDDFADDISLL 456
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 181 bits (458), Expect = 2e-45
Identities = 102/287 (35%), Positives = 154/287 (53%), Gaps = 57/287 (19%)
Query: 232 MCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSL 288
+CGAG P+ S + GGS+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L
Sbjct: 146 LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL 205
Query: 289 NLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLL------------------- 329
+DC+EYN DK+IVDSGTT LRLP+KVF+A V+++ AS
Sbjct: 206 KMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG 265
Query: 330 -------------------------------YIQPMMGAGLNY-ECYRFGISPSTNALVI 357
Y++P+ + +CY+F IS S+ V+
Sbjct: 266 TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVM 325
Query: 358 GATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPI 417
GA +MEGFYV+FDRA+KR+GFA S C + + GPF T D+ E
Sbjct: 326 GAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST 385
Query: 418 LWIVSYALMSVCGAILLVLIVLLLLPFRCQR--RPRDPEVVNDESSL 462
L ++Y + ++C A+ ++ + L++ +RC R R + + +D S L
Sbjct: 386 LMTIAYVMAAIC-ALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLL 431
Score = 109 bits (273), Expect = 5e-24
Identities = 51/93 (54%), Positives = 64/93 (68%)
Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLV 163
+ SSTYR V V YTQG W G +G DL+
Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLL 146
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 123 bits (308), Expect = 4e-28
Identities = 99/332 (29%), Positives = 156/332 (46%), Gaps = 59/332 (17%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTYRSKGF 143
Y+ E+ IGTPPQ +L DTGSSN V A T HS F+ SSTY + G
Sbjct: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSR----FNPSESSTYSTNGQ 128
Query: 144 DVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYAT 203
+++Y GS TGF G D +T+ + ++ NF +++GI+GLAY
Sbjct: 129 TFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA--QFDGIMGLAYPA 186
Query: 204 LAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262
L+ ++ T +V + + + VFS+ + G++GG++V GG++ SLY G
Sbjct: 187 LSVDEAT--TAMQGMVQEGALTSPVFSVYLSNQ------QGSSGGAVVFGGVDSSLYTGQ 238
Query: 263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEA 322
I++ P+ +E Y+QI I + IGGQ+ C E +AIVD+GT+LL +PQ+ A+++A
Sbjct: 239 IYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQA 295
Query: 323 VARASLLY---------IQPMMGAGLNYECYRFGISPSTNAL------------------ 355
Y IQ + F + PS+ L
Sbjct: 296 TGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQ 355
Query: 356 ------VIGATVMEGFYVIFDRAQKRVGFAAS 381
++G + +Y ++D RVGFA +
Sbjct: 356 NGQPLWILGDVFLRSYYSVYDLGNNRVGFATA 387
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 103 bits (257), Expect = 3e-22
Identities = 96/340 (28%), Positives = 155/340 (45%), Gaps = 63/340 (18%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTY------FDTERSSTYRSKGFDV 145
YY E+ IGTPPQ ++ DTGSSN V +D +++++SSTY G
Sbjct: 79 YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
Query: 146 TVKYTQGSWTGFVGEDLVTIP--KGFNTSFL--VNIATIFESENFFLPGI-----KWNGI 196
+ Y GS +G++ +D V++P + S L V + E PGI K++GI
Sbjct: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
Query: 197 LGLAYATLAKPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIE 255
LG+AY ++ +++ FD+L+ Q + N+FS L GG L+LGG +
Sbjct: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFY-----LSRDPDAQPGGELMLGGTD 251
Query: 256 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV 315
YKG + Y + + Y+Q+ + ++E+ L L C+E +AIVD+GT+L+ P
Sbjct: 252 SKYYKGSLSYLNVTRKAYWQVHLDQVEV-ASGLTL-CKE--GCEAIVDTGTSLMVGPVDE 307
Query: 316 FDAVVEAVARASLLYIQPMM------------------GAGLNYECYRFGIS-------- 349
+ +A+ L+ + M+ G L+ E Y +S
Sbjct: 308 VRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCL 367
Query: 350 ----------PSTNALVIGATVMEGFYVIFDRAQKRVGFA 379
PS ++G + +Y +FDR RVGFA
Sbjct: 368 SGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFA 407
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 100 bits (250), Expect = 2e-21
Identities = 88/330 (26%), Positives = 155/330 (46%), Gaps = 54/330 (16%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSSTYRSKGFDV 145
YY E+ IGTPPQ +++ DTGSSN V + S + T FD SS+Y+ G ++
Sbjct: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
Query: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
T++Y+ G+ +GF+ +D++T+ G + + T + F L +++G++G+ + +
Sbjct: 146 TLRYSTGTVSGFLSQDIITVG-GITVTQMFGEVTEMPALPFMLA--EFDGVVGMGF--IE 200
Query: 206 KPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264
+ + FD++++Q + +VFS S + GG +VLGG +P Y+G+
Sbjct: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYY---NRDSENSQSLGGQIVLGGSDPQHYEGNFH 257
Query: 265 YTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTL--------------LR 310
Y + + +QI++ + +G +L + + A+VD+G + L
Sbjct: 258 YINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYISGSTSSIEKLMEALG 313
Query: 311 LPQKVFDAVVEAVARASLLYIQPMMGAG---LNYECYRFGISPSTNAL------------ 355
+++FD VV+ +L I +G L Y F S S+ L
Sbjct: 314 AKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPP 373
Query: 356 ------VIGATVMEGFYVIFDRAQKRVGFA 379
+GAT + FY FDR R+GFA
Sbjct: 374 PTGPTWALGATFIRKFYTEFDRRNNRIGFA 403
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 98.6 bits (244), Expect = 1e-20
Identities = 85/329 (25%), Positives = 145/329 (44%), Gaps = 55/329 (16%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147
Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207
+Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLAV- 194
Query: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267
+ FD+++ Q N+ + M + G G L+ GG + S + G + + P
Sbjct: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249
Query: 268 IKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327
+ ++ Y+QI + +++GG + C E +AIVD+GT+L+ P + A+ A
Sbjct: 250 VTKQAYWQIALDNIQVGGTV--MFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP 305
Query: 328 L----------LYIQPMMGAGLNYECYRFGISPSTNAL---------------------- 355
+ L + P + +N Y +SP+ L
Sbjct: 306 VDGEYAVECANLNVMPDVTFTINGVPYT--LSPTAYTLLDFVDGMQFCSSGFQGLDIHPP 363
Query: 356 -----VIGATVMEGFYVIFDRAQKRVGFA 379
++G + FY +FDR RVG A
Sbjct: 364 AGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 95.9 bits (237), Expect = 7e-20
Identities = 93/332 (28%), Positives = 151/332 (45%), Gaps = 66/332 (19%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF--------- 316
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P
Sbjct: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
Query: 317 ------DAVVEAVARASL-----------------LYIQPMMGA------GLNYECYRFG 347
D VV A +SL YI G+ G+N
Sbjct: 300 SENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLP----- 354
Query: 348 ISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 379
+ S ++G + ++ +FDRA +VG A
Sbjct: 355 -TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 95.9 bits (237), Expect = 7e-20
Identities = 93/332 (28%), Positives = 151/332 (45%), Gaps = 66/332 (19%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF--------- 316
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P
Sbjct: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
Query: 317 ------DAVVEAVARASL-----------------LYIQPMMGA------GLNYECYRFG 347
D VV A +SL YI G+ G+N
Sbjct: 300 SENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLP----- 354
Query: 348 ISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 379
+ S ++G + ++ +FDRA +VG A
Sbjct: 355 -TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 95.9 bits (237), Expect = 7e-20
Identities = 91/326 (27%), Positives = 150/326 (46%), Gaps = 54/326 (16%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDKSGSVVIFGGIDSSYYTGSLNW 243
Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF--------- 316
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P
Sbjct: 244 VPVTVEGYWQITVDSITMNGET--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
Query: 317 ------DAVVEAVARASL-----------------LYIQPMMGAGLNYECYRFGISPSTN 353
D VV A +SL YI G+ ++ + S
Sbjct: 300 SENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGE 359
Query: 354 ALVIGATVMEGFYVIFDRAQKRVGFA 379
++G + ++ +FDRA +VG A
Sbjct: 360 LWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 79.3 bits (194), Expect = 7e-15
Identities = 54/191 (28%), Positives = 94/191 (49%), Gaps = 12/191 (6%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147
Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207
+Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLA-- 193
Query: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267
+ FD+++ Q N+ + M + G G L+ GG + S + G + + P
Sbjct: 194 VGGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249
Query: 268 IKEEWYYQIEI 278
+ ++ Y+QI +
Sbjct: 250 VTKQAYWQIAL 260
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 77.8 bits (190), Expect = 2e-14
Identities = 72/246 (29%), Positives = 120/246 (48%), Gaps = 22/246 (8%)
Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG------TPHSYIDTYFDTERSSTYRSKGFDV 145
Y+ E+ +GTPPQ + DTGSSN V + ++ FD + SS++++ G
Sbjct: 78 YFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKF 137
Query: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
++Y G G + ED +TI G + ++ ++E F ++GILGL + L+
Sbjct: 138 AIQYGTGRVDGILSEDKLTIG-GIKGASVIFGEALWEPSLVFAFA-HFDGILGLGFPILS 195
Query: 206 KPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264
+ D LV Q + VFS L +GG LVLGG +P+ Y +
Sbjct: 196 V--EGVRPPMDVLVEQGLLDKPVFSFY-----LNRDPEEPDGGELVLGGSDPAHYIPPLT 248
Query: 265 YTPIKEEWYYQIEILKLEIG-GQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAV 323
+ P+ Y+QI + ++++G G +L C + A AI+D+GT+L+ P + A+ A+
Sbjct: 249 FVPVTVPAYWQIHMERVKVGPGLTL---CAKGCA--AILDTGTSLITGPTEEIRALHAAI 303
Query: 324 ARASLL 329
LL
Sbjct: 304 GGIPLL 309
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 33.9 bits (76), Expect = 0.33
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 10/76 (13%)
Query: 395 SGPFSTEDVASNCVPAQSLSEP-ILWIVSYALMSVCGAILLVLIVLLLLPFRCQR----R 449
S P+S E V PAQ EP +LW+ V IL++LIV+ +L F+ +R
Sbjct: 1239 SSPYSDEIVVQ-VTPAQQQEEPEMLWVTG----PVLAVILIILIVIAILLFKRKRTHSPS 1293
Query: 450 PRDPEVVNDESSLVRH 465
+D + + + SL+ H
Sbjct: 1294 SKDEQSIGLKDSLLAH 1309
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 33.9 bits (76), Expect = 0.33
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 10/76 (13%)
Query: 395 SGPFSTEDVASNCVPAQSLSEP-ILWIVSYALMSVCGAILLVLIVLLLLPFRCQR----R 449
S P+S E V PAQ EP +LW+ V IL++LIV+ +L F+ +R
Sbjct: 1230 SSPYSDEIVVQ-VTPAQQQEEPEMLWVTG----PVLAVILIILIVIAILLFKRKRTHSPS 1284
Query: 450 PRDPEVVNDESSLVRH 465
+D + + + SL+ H
Sbjct: 1285 SKDEQSIGLKDSLLAH 1300
>gi|39995080 hypothetical protein LOC79567 [Homo sapiens]
Length = 1219
Score = 33.1 bits (74), Expect = 0.55
Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 11/81 (13%)
Query: 22 PELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHAD-GLALALEPALASPAGAANFLAM 80
P +PAP + +T + ++PTP P TPA +H+D LA+A++ + + AG + ++
Sbjct: 736 PLTSPAPDP-----SESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPVPTAAGGSGDRSL 790
Query: 81 VDNLQG-----DSGRGYYLEM 96
+ L D RG + E+
Sbjct: 791 EEALGALMAALDDYRGQFPEL 811
>gi|197927448 WD repeat domain 6 protein [Homo sapiens]
Length = 1151
Score = 33.1 bits (74), Expect = 0.55
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 225 PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIE-----PSLY----------KGDIWYTPIK 269
P V GAG PV GSG++GG G+ PSL+ G YT +
Sbjct: 558 PGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGR 617
Query: 270 EEWYYQIEILKLEIGGQSLNLDCREYN--ADKAIVDSGTTLL 309
+ YYQ+ + ++ CR N A IV G+ ++
Sbjct: 618 DGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVI 659
>gi|38683860 insulin receptor substrate 2 [Homo sapiens]
Length = 1338
Score = 32.7 bits (73), Expect = 0.72
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 12/89 (13%)
Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAM 80
+PE + LP R +A+ + + P P P P E + L A A A GAA+
Sbjct: 1007 SPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYR--LPPASAVATAQGPGAAS---- 1060
Query: 81 VDNLQGDSG-RGYYLEMLIG---TPPQKL 105
+L D+G G Y EM G TPPQ +
Sbjct: 1061 --SLSSDTGDNGDYTEMAFGVAATPPQPI 1087
>gi|19924099 synapsin I isoform Ia [Homo sapiens]
Length = 705
Score = 32.7 bits (73), Expect = 0.72
Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 46 TPGPGTPAERHADGLALALEPALASP--AGAANFLAMVDN 83
TPGPGT + G+A A PA SP +G F + + N
Sbjct: 43 TPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSN 82
>gi|19924097 synapsin I isoform Ib [Homo sapiens]
Length = 669
Score = 32.7 bits (73), Expect = 0.72
Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 46 TPGPGTPAERHADGLALALEPALASP--AGAANFLAMVDN 83
TPGPGT + G+A A PA SP +G F + + N
Sbjct: 43 TPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSN 82
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 32.3 bits (72), Expect = 0.95
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 117 AVAGTPHSYIDTY-FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLV 175
A A P Y T+ F TE ++ R++G +VT Y G LVT+ N S
Sbjct: 1402 ACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDP------GSYLVTVTASNNISAAN 1455
Query: 176 NIATIFESENFFLPGIKWNGILGL 199
+ A + E + IK NG LGL
Sbjct: 1456 DSALVEVQEPVLVTSIKVNGSLGL 1479
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 32.3 bits (72), Expect = 0.95
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 117 AVAGTPHSYIDTY-FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLV 175
A A P Y T+ F TE ++ R++G +VT Y G LVT+ N S
Sbjct: 1402 ACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDP------GSYLVTVTASNNISAAN 1455
Query: 176 NIATIFESENFFLPGIKWNGILGL 199
+ A + E + IK NG LGL
Sbjct: 1456 DSALVEVQEPVLVTSIKVNGSLGL 1479
>gi|239753114 PREDICTED: hypothetical protein [Homo sapiens]
Length = 322
Score = 32.0 bits (71), Expect = 1.2
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 5/45 (11%)
Query: 11 PLLAQWLLRAAPELA-----PAPFTLPLRVAAATNRVVAPTPGPG 50
PL+A ++AP L PAP L LR A+ + AP+PG G
Sbjct: 204 PLIAPGAHQSAPPLPVLGRLPAPLPLQLRAGGASTGLAAPSPGRG 248
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 32.0 bits (71), Expect = 1.2
Identities = 24/60 (40%), Positives = 26/60 (43%), Gaps = 9/60 (15%)
Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAER-------HADGLALALEPALASPAG 73
AP A AP P AAA P+PGP P R A A A PA+A PAG
Sbjct: 138 APVAAAAPARAPRAAAAAA--TAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAG 195
>gi|124378039 SEC16 homolog A [Homo sapiens]
Length = 2357
Score = 31.2 bits (69), Expect = 2.1
Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 3/71 (4%)
Query: 19 RAAPELAPAPFTLPLRVAAATNRVVAPTPG---PGTPAERHADGLALALEPALASPAGAA 75
R+ P LAPA F PL + + PTP P P +G A A A PA
Sbjct: 2204 RSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEP 2263
Query: 76 NFLAMVDNLQG 86
L+ +L G
Sbjct: 2264 KVLSSAASLPG 2274
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 31.2 bits (69), Expect = 2.1
Identities = 26/71 (36%), Positives = 34/71 (47%), Gaps = 3/71 (4%)
Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHAD-GLALALEPALASPAG-AANFL 78
APE P T P A VV TP P PAE D G +L P ++ P G A + L
Sbjct: 209 APEDPSGPGTGPSGTCEAPVAVVTVTPAP-EPAENSQDLGSTSSLGPGISGPRGQAPDTL 267
Query: 79 AMVDNLQGDSG 89
+ +D++ SG
Sbjct: 268 SYLDSVSLMSG 278
>gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Homo
sapiens]
Length = 305
Score = 30.0 bits (66), Expect = 4.7
Identities = 25/60 (41%), Positives = 29/60 (48%), Gaps = 3/60 (5%)
Query: 17 LLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPG-TPAERHADGLALALEPALA-SPAGA 74
+L AP APAP P+ A V+AP P P PA A A A PA A +PA A
Sbjct: 142 VLAPAPAPAPAPVAAPVAAPVAV-AVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPA 200
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,339,428
Number of Sequences: 37866
Number of extensions: 889210
Number of successful extensions: 2705
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2600
Number of HSP's gapped (non-prelim): 95
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.