Guide to the Human Genome
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Name: HFE Sequence: fasta or formatted (246aa) NCBI GI: 21040351
Description:

hemochromatosis protein isoform 8 precursor

Referenced in:

HLA and Related Proteins
Iron, Copper, and Arsenic Metabolism

Other entries for this name:
alt prot [242aa] hemochromatosis protein isoform 3 precursor
alt prot [256aa] hemochromatosis protein isoform 4 precursor
alt prot [334aa] hemochromatosis protein isoform 6 precursor
alt prot [260aa] hemochromatosis protein isoform 7 precursor
alt prot [325aa] hemochromatosis protein isoform 9 precursor
alt prot [168aa] hemochromatosis protein isoform 10 precursor
alt prot [76aa] hemochromatosis protein isoform 11 precursor
alt prot [348aa] hemochromatosis protein isoform 1 precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.1         15           2
 C cysteine            2.0          5           1
 D aspartate           4.9         12           1
 E glutamate           6.9         17           2
 F phenylalanine       2.0          5           1
 G glycine             8.1         20           1
 H histidine           2.0          5           1
 I isoleucine          5.7         14           2
 K lysine              3.7          9           1
 L leucine            13.0         32           4
 M methionine          2.4          6           1
 N asparagine          2.0          5           1
 P proline             6.5         16           2
 Q glutamine           7.7         19           2
 R arginine            7.3         18           1
 S serine              2.4          6           1
 T threonine           4.9         12           2
 V valine              5.7         14           2
 W tryptophan          2.8          7           1
 Y tyrosine            3.7          9           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   hemochromatosis protein isoform 8 precursor 
HFE                   0.979   hemochromatosis protein isoform 7 precursor 
HFE                   0.903   hemochromatosis protein isoform 6 precursor 
HFE                   0.885   hemochromatosis protein isoform 9 precursor 
HFE                   0.885   hemochromatosis protein isoform 1 precursor 
HFE                   0.587   hemochromatosis protein isoform 3 precursor 
HFE                   0.583   hemochromatosis protein isoform 4 precursor 
HFE                   0.499   hemochromatosis protein isoform 10 precursor 
HLA-B                 0.273   major histocompatibility complex, class I, B precurs...
LOC652614             0.257   PREDICTED: similar to MHC class I antigen 
HLA-F                 0.255   major histocompatibility complex, class I, F isofor...
HLA-F                 0.255   major histocompatibility complex, class I, F isofor...
HLA-C                 0.253   major histocompatibility complex, class I, C precurs...
HLA-A                 0.246   major histocompatibility complex, class I, A precurs...
AZGP1                 0.240   alpha-2-glycoprotein 1, zinc 
HLA-G                 0.240   major histocompatibility complex, class I, G precurso...
MR1                   0.240   major histocompatibility complex, class I-related [Ho...
HLA-E                 0.232   major histocompatibility complex, class I, E precurs...
MICA                  0.160   MHC class I polypeptide-related sequence A 
MICB                  0.154   MHC class I polypeptide-related sequence B 
HFE                   0.152   hemochromatosis protein isoform 11 precursor 
FCGRT                 0.152   Fc fragment of IgG, receptor, transporter, alpha [H...
FCGRT                 0.152   Fc fragment of IgG, receptor, transporter, alpha [Hom...
LOC100294318          0.119   PREDICTED: similar to major histocompatibility comp...
LOC100294318          0.117   PREDICTED: similar to major histocompatibility comp...
LOC100133583          0.111   PREDICTED: similar to major histocompatibility comp...
HLA-DPB1              0.109   major histocompatibility complex, class II, DP beta ...
HLA-DQB1              0.103   major histocompatibility complex, class II, DQ beta...
HLA-DRB4              0.103   major histocompatibility complex, class II, DR beta ...
HLA-DRB4              0.103   PREDICTED: major histocompatibility complex, class ...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
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