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Search of human proteins with 19913369
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19913369 transducin beta-like 3 [Homo sapiens]
(808 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19913369 transducin beta-like 3 [Homo sapiens] 1635 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 120 4e-27
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 117 3e-26
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 112 1e-24
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 112 1e-24
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 112 1e-24
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 111 2e-24
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 111 2e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 110 4e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 110 4e-24
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 109 1e-23
gi|26665869 WD repeat domain 51B [Homo sapiens] 107 4e-23
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 107 6e-23
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 105 1e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 105 2e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens] 104 3e-22
gi|23199987 WD repeat domain 5B [Homo sapiens] 103 8e-22
gi|16554629 WD repeat domain 5 [Homo sapiens] 102 1e-21
gi|16554627 WD repeat domain 5 [Homo sapiens] 102 1e-21
gi|13376840 WD repeat domain 61 [Homo sapiens] 101 2e-21
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 98 3e-20
gi|18874090 WD repeat domain 48 [Homo sapiens] 96 1e-19
gi|113865883 WD repeat domain 38 [Homo sapiens] 96 2e-19
gi|4757988 WD repeat domain 39 [Homo sapiens] 95 2e-19
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 94 4e-19
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 94 4e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 94 5e-19
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 93 9e-19
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 93 1e-18
gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens] 92 3e-18
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 1635 bits (4234), Expect = 0.0
Identities = 808/808 (100%), Positives = 808/808 (100%)
Query: 1 MAETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRS 60
MAETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRS
Sbjct: 1 MAETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRS 60
Query: 61 LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPT 120
LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPT
Sbjct: 61 LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPT 120
Query: 121 STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVW 180
STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVW
Sbjct: 121 STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVW 180
Query: 181 SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVE 240
SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVE
Sbjct: 181 SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVE 240
Query: 241 AAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTL 300
AAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTL
Sbjct: 241 AAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTL 300
Query: 301 AHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLK 360
AHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLK
Sbjct: 301 AHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLK 360
Query: 361 VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 420
VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH
Sbjct: 361 VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 420
Query: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK
Sbjct: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
Query: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 541 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRT 600
ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRT
Sbjct: 541 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRT 600
Query: 601 LDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNL 660
LDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNL
Sbjct: 601 LDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNL 660
Query: 661 LHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLRFCVT 720
LHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLRFCVT
Sbjct: 661 LHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLRFCVT 720
Query: 721 WNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAF 780
WNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAF
Sbjct: 721 WNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAF 780
Query: 781 LDFLWHNMKLPVPAAAPTPWETHKGALP 808
LDFLWHNMKLPVPAAAPTPWETHKGALP
Sbjct: 781 LDFLWHNMKLPVPAAAPTPWETHKGALP 808
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 120 bits (302), Expect = 4e-27
Identities = 80/343 (23%), Positives = 155/343 (45%), Gaps = 26/343 (7%)
Query: 295 LTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVAS 354
LT+ L + +T + D L++ S G+ V + F P + S
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 355 NSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMC 413
K++ ++T C GHT ++ L + L A+ + D + ++W + +V
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 414 VAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP---ILLQ 470
+ GH+ + ++ + + ++TGS D TV +W D G IL+
Sbjct: 215 LR---GHSAEIISLSFNTSGDR-IITGSFDHTVVVWDA-----------DTGRKVNILIG 259
Query: 471 AQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFS 530
H +I+S + + L+ TGS D+T KLW + + +GH + F
Sbjct: 260 -------HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 531 PMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
+++ATASADGT ++++ C+ EGH+ + K++F +G LL+ SD ++W
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 591 TIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
+ +C++ L+ H D+++ + + +TG+ D+ +W+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 112 bits (281), Expect = 1e-24
Identities = 78/338 (23%), Positives = 148/338 (43%), Gaps = 19/338 (5%)
Query: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFD-PTSTLLATG 127
+T L+ +T S W G + H V +AF+ P +ATG
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG-HRNVVYAIAFNNPYGDKIATG 153
Query: 128 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 187
D ++W + H FRG + ++F+P T L+ + + D ++W +Q+
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST--LVATGSMDTTAKLWDIQNGEE 211
Query: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 247
+ L H + + SL+F+ G +++ D ++WD + + + + E
Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-NILIGHCAE------- 263
Query: 248 EPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVV 307
+S LT T ++W+A +G+CV T G E+ +T ++
Sbjct: 264 --ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---GHDDEILDSCFDYTGKLI 318
Query: 308 LTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTS 367
TA+AD ++ A + + + G+ E+ + F P+ +H++ S+ ++++ QT
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISF-NPQGNHLLTGSSDKTARIWDAQTG 377
Query: 368 AC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWR 404
C Q+L GHTD + + KG + + +KD + RIWR
Sbjct: 378 QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 100 bits (250), Expect = 4e-21
Identities = 52/158 (32%), Positives = 81/158 (51%), Gaps = 1/158 (0%)
Query: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQF-SPMDQ 534
+ H + +VA+ + TGS DRT KLW + L GHR ++ + F +P
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 535 VLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
+AT S D T KLW+++ C TF GH A ++ ++F + T + + D KLW I+N
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 595 NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
E V TL H ++ L + D +TG+ D V++W
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 92.8 bits (229), Expect = 1e-18
Identities = 68/301 (22%), Positives = 123/301 (40%), Gaps = 38/301 (12%)
Query: 51 EVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTA 110
+ ASG L +LE +P + + T S W+ + G ++ HTA
Sbjct: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG-HTA 178
Query: 111 PVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFS 170
+ ++F+P STL+ATG D ++WDI + RG + ++F+ R++ +
Sbjct: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--T 236
Query: 171 SATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD------- 223
+ D + VW + +L H + ++S +F+ D +L+ DK C +WD
Sbjct: 237 GSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 224 ----------LQSC-----------QATRTVPVFESVEAAVLLP----EEPVSQLGVKSP 258
L SC A T +F + + E +S++
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
Query: 259 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
G + LT T R+W+A +GQC+ G E+ C + +V+T + D+ +
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVL---EGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Query: 319 Y 319
+
Sbjct: 414 W 414
Score = 87.4 bits (215), Expect = 5e-17
Identities = 80/360 (22%), Positives = 144/360 (40%), Gaps = 33/360 (9%)
Query: 190 VLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEP 249
VL AH +T++A + G ++ D+ C +WD S + T+ +V A+ P
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-NNP 145
Query: 250 VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLT 309
G T T ++W +G+C +T G E+ + + +V T
Sbjct: 146 Y--------GDKIATGSFDKTCKLWSVETGKCYHTFR---GHTAEIVCLSFNPQSTLVAT 194
Query: 310 ATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTS-A 368
+ D L++ ++ G+S E++ + F ++ S + V++ T
Sbjct: 195 GSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF-NTSGDRIITGSFDHTVVVWDADTGRK 253
Query: 369 CQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVC 428
IL GH + + L + + D++ ++W A CVA +GH +
Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLTGHDDEI-LDS 309
Query: 429 CSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIA 488
C + T S D T +++ A K A G H+ +I+ ++
Sbjct: 310 CFDYTGKLIATASADGTARIF---SAATRKCIAKLEG------------HEGEISKISFN 354
Query: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
P L TGS D+TA++W Q L V GH ++ F+ ++ T S D T ++W
Sbjct: 355 PQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 6/190 (3%)
Query: 45 TRVNILEVASGAVLRSLEQEDQEDIT-AFDLSPDNEVLVTASRALLLAQWAWQEGSVTRL 103
T + ++ +G + +L E I+ +F+ S D ++T S + W G +
Sbjct: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR--IITGSFDHTVVVWDADTGRKVNI 256
Query: 104 WKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDP 163
H A +++ +F+ +L+ TG D ++WD G + F D
Sbjct: 257 LIG-HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF--DY 313
Query: 164 TRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
T L+ +++ D R++S R C+A L H ++ ++F+ G+ +L+ DK IWD
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 224 LQSCQATRTV 233
Q+ Q + +
Sbjct: 374 AQTGQCLQVL 383
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/129 (28%), Positives = 54/129 (41%), Gaps = 2/129 (1%)
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
L V H L V + T S D T KLW L T EGH V +AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 573 SRGTQLLSSGS-DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVIL 631
+ +++GS D KLW+++ +C T H ++ L + TG+ D+ L
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 632 WKDVTEAEQ 640
W D+ E+
Sbjct: 204 W-DIQNGEE 211
Score = 35.8 bits (81), Expect = 0.16
Identities = 21/81 (25%), Positives = 34/81 (41%), Gaps = 1/81 (1%)
Query: 553 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
F K + H + VA G+ ++ D KLW + E + TL+ H + V+ +
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141
Query: 613 CSR-LDDHALTGASDSRVILW 632
+ D TG+ D LW
Sbjct: 142 FNNPYGDKIATGSFDKTCKLW 162
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 117 bits (294), Expect = 3e-26
Identities = 87/324 (26%), Positives = 140/324 (43%), Gaps = 41/324 (12%)
Query: 331 AGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGW 389
+G+ V V F P S +V AS +KV++ +T + L GHTD V + G
Sbjct: 105 SGHRSPVTRVIF-HPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 390 LFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
L ASC+ D ++++W C+ GH H+V +V +V+ S+D T+K+W
Sbjct: 164 LLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMW 219
Query: 450 PLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP 509
+ K T H + + V + L+A+ S D+T ++W +
Sbjct: 220 EVQTGYCVK---------------TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
Query: 510 QCQLLGVFSGHRRGLWCVQFSPMDQV--------------------LATASADGTIKLWA 549
+ H + C+ ++P L + S D TIK+W
Sbjct: 265 TKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324
Query: 550 LQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVW 609
+ CL T GHD V V F S G +LS D +++W KN C++TL+AHE V
Sbjct: 325 VSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT 384
Query: 610 GLHCSRLDDHALTGASDSRVILWK 633
L + + +TG+ D V +W+
Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 94.0 bits (232), Expect = 5e-19
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 2/175 (1%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H + V P ++ + S+D T K+W GH + + F ++LA
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+ SAD TIKLW Q F C++T GHD +V VA + G ++S+ D +K+W ++ C
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 598 VRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652
V+T H + V + ++ + ++D V +W V ++ + + R+ E VV
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW--VVATKECKAELREHEHVV 279
Score = 89.4 bits (220), Expect = 1e-17
Identities = 76/344 (22%), Positives = 138/344 (40%), Gaps = 45/344 (13%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
H +PV + F P +++ + D ++VWD +G V ++F D + L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF--DHSGKL 164
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
L S + D I++W Q C+ + H V+S+A +G ++S+ RDK +W++Q+
Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG 224
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+T E V + G + + T+RVW A+ +C
Sbjct: 225 YCVKTFTGH----------REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC------ 268
Query: 288 PPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEV-LDVRFLGPE 346
A + + E S + ++ SE + + G
Sbjct: 269 ---------------------KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307
Query: 347 DSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRM 405
++ S +K++++ T C L GH + V + G SCA D+++R+W
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 406 NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
C+ + H H V ++ + ++VTGS D TVK+W
Sbjct: 368 KNK---RCMKTLNAHEHFVTSLDFHK-TAPYVVTGSVDQTVKVW 407
Score = 79.0 bits (193), Expect = 2e-14
Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 1/135 (0%)
Query: 499 QDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Q R K W +P+ SGHR + V F P+ V+ +AS D TIK+W + +T
Sbjct: 87 QKRDPKEW-IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT 145
Query: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDD 618
+GH SV ++F G L S +D +KLW + EC+RT+ H+ V + D
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD 205
Query: 619 HALTGASDSRVILWK 633
H ++ + D + +W+
Sbjct: 206 HIVSASRDKTIKMWE 220
Score = 47.4 bits (111), Expect = 5e-05
Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
L +G D +++WD+ G V V FH +L S A D +RVW +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFIL--SCADDKTLRVWDYK 368
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
++ C+ L AH VTSL F +++ D+ +W+
Sbjct: 369 NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 112 bits (280), Expect = 1e-24
Identities = 80/323 (24%), Positives = 153/323 (47%), Gaps = 38/323 (11%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFA 392
SE V L +D ++ +K+++ + C ++L GHT VL L + +
Sbjct: 237 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 294
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
+ + D +VR+W +N G+V+ H V R +VT S+D ++ +W +
Sbjct: 295 TGSSDSTVRVWDVN-TGEVLNTL-----IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 348
Query: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
A I L+ H +N V +DK + + S DRT K+W+ C+
Sbjct: 349 SAT----------DITLRRVLVG--HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE 394
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 395 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 452
Query: 573 SRGTQLLSSGSDGLVKLWTIK---------NNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
++ +++S DG +K+W ++ + C+RTL H +V+ L ++
Sbjct: 453 NK--RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISS 508
Query: 624 ASDSRVILWKDVTEAEQAEEQAR 646
+ D +++W + A+ + R
Sbjct: 509 SHDDTILIWDFLNVPPSAQNETR 531
Score = 60.8 bits (146), Expect = 5e-09
Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 49/298 (16%)
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+ S D +I++W CL VLT H +V L + D +++ D +WD+ +
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 310
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ T ++ E V L S GL +T ++ VW+ AS +
Sbjct: 311 EVLNT----------LIHHNEAVLHLRF-SNGL-MVTCSKDRSIAVWDMASATDI----- 353
Query: 288 PPGPGQELTHCTLAHTAGV---------VLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338
L + H A V +++A+ D + ++ + + G+ +
Sbjct: 354 ------TLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 407
Query: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKD 397
+++ D VV S+ +++++++ AC ++L GH ++V + K S A D
Sbjct: 408 CLQY---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYD 462
Query: 398 QSVRIWRMNKA------GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
+++W + A +C+ H+ G V + E +++ S D T+ +W
Sbjct: 463 GKIKVWDLQAALDPRAPASTLCLRTLVEHS---GRVFRLQFDEFQIISSSHDDTILIW 517
Score = 55.1 bits (131), Expect = 3e-07
Identities = 51/244 (20%), Positives = 103/244 (42%), Gaps = 23/244 (9%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
+ +G D ++++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVRVWDVN 308
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
L L H AV L FS M++ +D+ +WD+ S V AAV
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 366
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 367 NV---------VDFDDKYIVSASGDRTIKVWSTSTCEFVRTL-----NGHKRGIACLQYR 412
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 413 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 469
Query: 364 LQTS 367
LQ +
Sbjct: 470 LQAA 473
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V + +V +G VL +L ++ L N ++VT S+ +A W + L +
Sbjct: 302 VRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 358
Query: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H A V + FD + A+G D ++VW G + + +
Sbjct: 359 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR-- 414
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 415 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 470
Query: 225 QS 226
Q+
Sbjct: 471 QA 472
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 31/182 (17%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI----VRHYGTHHFRGSPGVVHLVAFHPDP 163
HT V + +D ++ TG D VRVWD+ V + HH + V+HL
Sbjct: 279 HTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHH---NEAVLHLRF----- 328
Query: 164 TRLLLFSSATDAAIRVW---SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
+ L+ + + D +I VW S D + VL H +AV + F D ++S+ D+
Sbjct: 329 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 386
Query: 221 IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ 280
+W +C+ RT+ + A + + V ++ T+R+W+ G
Sbjct: 387 VWSTSTCEFVRTLNGHKRGIACLQYRDRLV------------VSGSSDNTIRLWDIECGA 434
Query: 281 CV 282
C+
Sbjct: 435 CL 436
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 112 bits (280), Expect = 1e-24
Identities = 80/323 (24%), Positives = 153/323 (47%), Gaps = 38/323 (11%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFA 392
SE V L +D ++ +K+++ + C ++L GHT VL L + +
Sbjct: 203 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 260
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
+ + D +VR+W +N G+V+ H V R +VT S+D ++ +W +
Sbjct: 261 TGSSDSTVRVWDVN-TGEVLNTL-----IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 314
Query: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
A I L+ H +N V +DK + + S DRT K+W+ C+
Sbjct: 315 SAT----------DITLRRVLVG--HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE 360
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 361 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 418
Query: 573 SRGTQLLSSGSDGLVKLWTIK---------NNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
++ +++S DG +K+W ++ + C+RTL H +V+ L ++
Sbjct: 419 NK--RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISS 474
Query: 624 ASDSRVILWKDVTEAEQAEEQAR 646
+ D +++W + A+ + R
Sbjct: 475 SHDDTILIWDFLNVPPSAQNETR 497
Score = 60.8 bits (146), Expect = 5e-09
Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 49/298 (16%)
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+ S D +I++W CL VLT H +V L + D +++ D +WD+ +
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 276
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ T ++ E V L S GL +T ++ VW+ AS +
Sbjct: 277 EVLNT----------LIHHNEAVLHLRF-SNGL-MVTCSKDRSIAVWDMASATDI----- 319
Query: 288 PPGPGQELTHCTLAHTAGV---------VLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338
L + H A V +++A+ D + ++ + + G+ +
Sbjct: 320 ------TLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 373
Query: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKD 397
+++ D VV S+ +++++++ AC ++L GH ++V + K S A D
Sbjct: 374 CLQY---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYD 428
Query: 398 QSVRIWRMNKA------GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
+++W + A +C+ H+ G V + E +++ S D T+ +W
Sbjct: 429 GKIKVWDLQAALDPRAPASTLCLRTLVEHS---GRVFRLQFDEFQIISSSHDDTILIW 483
Score = 55.1 bits (131), Expect = 3e-07
Identities = 51/244 (20%), Positives = 103/244 (42%), Gaps = 23/244 (9%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
+ +G D ++++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVRVWDVN 274
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
L L H AV L FS M++ +D+ +WD+ S V AAV
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 333 NV---------VDFDDKYIVSASGDRTIKVWSTSTCEFVRTL-----NGHKRGIACLQYR 378
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 379 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 435
Query: 364 LQTS 367
LQ +
Sbjct: 436 LQAA 439
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V + +V +G VL +L ++ L N ++VT S+ +A W + L +
Sbjct: 268 VRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 324
Query: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H A V + FD + A+G D ++VW G + + +
Sbjct: 325 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR-- 380
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 381 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
Query: 225 QS 226
Q+
Sbjct: 437 QA 438
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 31/182 (17%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI----VRHYGTHHFRGSPGVVHLVAFHPDP 163
HT V + +D ++ TG D VRVWD+ V + HH + V+HL
Sbjct: 245 HTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHH---NEAVLHLRF----- 294
Query: 164 TRLLLFSSATDAAIRVW---SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
+ L+ + + D +I VW S D + VL H +AV + F D ++S+ D+
Sbjct: 295 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 352
Query: 221 IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ 280
+W +C+ RT+ + A + + V ++ T+R+W+ G
Sbjct: 353 VWSTSTCEFVRTLNGHKRGIACLQYRDRLV------------VSGSSDNTIRLWDIECGA 400
Query: 281 CV 282
C+
Sbjct: 401 CL 402
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 112 bits (280), Expect = 1e-24
Identities = 80/323 (24%), Positives = 153/323 (47%), Gaps = 38/323 (11%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFA 392
SE V L +D ++ +K+++ + C ++L GHT VL L + +
Sbjct: 224 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 281
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
+ + D +VR+W +N G+V+ H V R +VT S+D ++ +W +
Sbjct: 282 TGSSDSTVRVWDVN-TGEVLNTL-----IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 335
Query: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
A I L+ H +N V +DK + + S DRT K+W+ C+
Sbjct: 336 SAT----------DITLRRVLVG--HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE 381
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 382 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 439
Query: 573 SRGTQLLSSGSDGLVKLWTIK---------NNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
++ +++S DG +K+W ++ + C+RTL H +V+ L ++
Sbjct: 440 NK--RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISS 495
Query: 624 ASDSRVILWKDVTEAEQAEEQAR 646
+ D +++W + A+ + R
Sbjct: 496 SHDDTILIWDFLNVPPSAQNETR 518
Score = 60.8 bits (146), Expect = 5e-09
Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 49/298 (16%)
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+ S D +I++W CL VLT H +V L + D +++ D +WD+ +
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 297
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ T ++ E V L S GL +T ++ VW+ AS +
Sbjct: 298 EVLNT----------LIHHNEAVLHLRF-SNGL-MVTCSKDRSIAVWDMASATDI----- 340
Query: 288 PPGPGQELTHCTLAHTAGV---------VLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338
L + H A V +++A+ D + ++ + + G+ +
Sbjct: 341 ------TLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 394
Query: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKD 397
+++ D VV S+ +++++++ AC ++L GH ++V + K S A D
Sbjct: 395 CLQY---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYD 449
Query: 398 QSVRIWRMNKA------GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
+++W + A +C+ H+ G V + E +++ S D T+ +W
Sbjct: 450 GKIKVWDLQAALDPRAPASTLCLRTLVEHS---GRVFRLQFDEFQIISSSHDDTILIW 504
Score = 55.1 bits (131), Expect = 3e-07
Identities = 51/244 (20%), Positives = 103/244 (42%), Gaps = 23/244 (9%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
+ +G D ++++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVRVWDVN 295
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
L L H AV L FS M++ +D+ +WD+ S V AAV
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 354 NV---------VDFDDKYIVSASGDRTIKVWSTSTCEFVRTL-----NGHKRGIACLQYR 399
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 400 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 456
Query: 364 LQTS 367
LQ +
Sbjct: 457 LQAA 460
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V + +V +G VL +L ++ L N ++VT S+ +A W + L +
Sbjct: 289 VRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 345
Query: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H A V + FD + A+G D ++VW G + + +
Sbjct: 346 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR-- 401
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 402 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457
Query: 225 QS 226
Q+
Sbjct: 458 QA 459
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 31/182 (17%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI----VRHYGTHHFRGSPGVVHLVAFHPDP 163
HT V + +D ++ TG D VRVWD+ V + HH + V+HL
Sbjct: 266 HTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHH---NEAVLHLRF----- 315
Query: 164 TRLLLFSSATDAAIRVW---SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
+ L+ + + D +I VW S D + VL H +AV + F D ++S+ D+
Sbjct: 316 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 373
Query: 221 IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ 280
+W +C+ RT+ + A + + V ++ T+R+W+ G
Sbjct: 374 VWSTSTCEFVRTLNGHKRGIACLQYRDRLV------------VSGSSDNTIRLWDIECGA 421
Query: 281 CV 282
C+
Sbjct: 422 CL 423
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 111 bits (278), Expect = 2e-24
Identities = 83/321 (25%), Positives = 151/321 (47%), Gaps = 41/321 (12%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFA 392
SE V L +D +V +K+++ T C+ IL GHT VL L + +
Sbjct: 264 SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VII 321
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
+ + D +VR+W +N + + H V R +VT S+D ++ +W +
Sbjct: 322 TGSSDSTVRVWDVNTGEMLNTLI------HHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 375
Query: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
P + + H +N V +DK + + S DRT K+W C+
Sbjct: 376 S------------PTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCE 421
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 422 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 479
Query: 573 SRGTQLLSSGSDGLVKLWTI---------KNNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
++ +++S DG +K+W + C+RTL H +V+ L + D+ +
Sbjct: 480 NK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL---QFDEFQIVS 534
Query: 624 AS-DSRVILWKDVTE-AEQAE 642
+S D +++W + + A QAE
Sbjct: 535 SSHDDTILIWDFLNDPAAQAE 555
Score = 50.1 bits (118), Expect = 8e-06
Identities = 49/241 (20%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
+ +G D +++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVN 335
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
L L H AV L F + M++ +D+ +WD+ S V AAV
Sbjct: 336 TGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV 393
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 394 NV---------VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL-----NGHKRGIACLQYR 439
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 440 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 496
Query: 364 L 364
L
Sbjct: 497 L 497
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 32/216 (14%)
Query: 74 LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133
L D++ +V+ R + W R+ HT V + +D ++ TG D V
Sbjct: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQYD--ERVIITGSSDSTV 329
Query: 134 RVWDI----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL---QDRS 186
RVWD+ + + HH V+HL F+ ++ + + D +I VW + D +
Sbjct: 330 RVWDVNTGEMLNTLIHH---CEAVLHL-RFNNG----MMVTCSKDRSIAVWDMASPTDIT 381
Query: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP 246
VL H +AV + F D ++S+ D+ +W+ +C+ RT+ + A +
Sbjct: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
Query: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCV 282
+ V ++ T+R+W+ G C+
Sbjct: 440 DRLV------------VSGSSDNTIRLWDIECGACL 463
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 13/180 (7%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V + +V +G +L +L + L +N ++VT S+ +A W + L +
Sbjct: 329 VRVWDVNTGEMLNTLIHHCE---AVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRV 385
Query: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H A V + FD + A+G D ++VW+ G + + +
Sbjct: 386 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-- 441
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 442 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 497
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 111 bits (278), Expect = 2e-24
Identities = 83/321 (25%), Positives = 151/321 (47%), Gaps = 41/321 (12%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFA 392
SE V L +D +V +K+++ T C+ IL GHT VL L + +
Sbjct: 300 SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VII 357
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
+ + D +VR+W +N + + H V R +VT S+D ++ +W +
Sbjct: 358 TGSSDSTVRVWDVNTGEMLNTLI------HHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 411
Query: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
P + + H +N V +DK + + S DRT K+W C+
Sbjct: 412 S------------PTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCE 457
Query: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 458 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 515
Query: 573 SRGTQLLSSGSDGLVKLWTI---------KNNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
++ +++S DG +K+W + C+RTL H +V+ L + D+ +
Sbjct: 516 NK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL---QFDEFQIVS 570
Query: 624 AS-DSRVILWKDVTE-AEQAE 642
+S D +++W + + A QAE
Sbjct: 571 SSHDDTILIWDFLNDPAAQAE 591
Score = 50.1 bits (118), Expect = 8e-06
Identities = 49/241 (20%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
+ +G D +++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVN 371
Query: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
L L H AV L F + M++ +D+ +WD+ S V AAV
Sbjct: 372 TGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV 429
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 430 NV---------VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL-----NGHKRGIACLQYR 475
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 476 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 532
Query: 364 L 364
L
Sbjct: 533 L 533
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 32/216 (14%)
Query: 74 LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133
L D++ +V+ R + W R+ HT V + +D ++ TG D V
Sbjct: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQYD--ERVIITGSSDSTV 365
Query: 134 RVWDI----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL---QDRS 186
RVWD+ + + HH V+HL F+ ++ + + D +I VW + D +
Sbjct: 366 RVWDVNTGEMLNTLIHH---CEAVLHL-RFNNG----MMVTCSKDRSIAVWDMASPTDIT 417
Query: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP 246
VL H +AV + F D ++S+ D+ +W+ +C+ RT+ + A +
Sbjct: 418 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 475
Query: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCV 282
+ V ++ T+R+W+ G C+
Sbjct: 476 DRLV------------VSGSSDNTIRLWDIECGACL 499
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 13/180 (7%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V + +V +G +L +L + L +N ++VT S+ +A W + L +
Sbjct: 365 VRVWDVNTGEMLNTLIHHCE---AVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRV 421
Query: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H A V + FD + A+G D ++VW+ G + + +
Sbjct: 422 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-- 477
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 478 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 533
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 110 bits (276), Expect = 4e-24
Identities = 83/311 (26%), Positives = 140/311 (45%), Gaps = 25/311 (8%)
Query: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDV 384
L++ F G+ + V V F + S CL V+ ++ S GH D V ++
Sbjct: 11 LERHFKGHRDAVTCVDF-SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 385 FRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444
G L AS ++D++VRIW N G+ HT +V +V +SF VT S D
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFR---AHTATVRSVHFCSDGQSF-VTASDDK 125
Query: 445 TVKLWPL--PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRT 502
TVK+W K L S + H + +P+ +L+ + S D+T
Sbjct: 126 TVKVWATHRQKFLFSLSQ-----------------HINWVRCAKFSPDGRLIVSASDDKT 168
Query: 503 AKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGH 562
KLW + + + H + V F P +A A D T+K+W ++ L+ ++ H
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228
Query: 563 DASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALT 622
A+V ++F G L+++ SD +K+ + + TL H+ + SR ++ +
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 288
Query: 623 GASDSRVILWK 633
G SD +V++WK
Sbjct: 289 GGSDEQVMVWK 299
Score = 97.1 bits (240), Expect = 6e-20
Identities = 76/312 (24%), Positives = 137/312 (43%), Gaps = 18/312 (5%)
Query: 96 QEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVH 155
++ S+ R +K H V + F + LA+G D + VW + + F G V
Sbjct: 7 EDPSLERHFKG-HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 156 LVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGR 215
V F P+ LL S + D +R+W + V AH + V S+ F +DG + +++
Sbjct: 66 CVNF--SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 216 DKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
DK +W AT S+ + V G ++A D T+++W+
Sbjct: 124 DKTVKVW------ATHRQKFLFSLSQHI----NWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335
+S +CV++ + G +T+ + + A D+ + +++ R+ RL + + +S
Sbjct: 174 KSSRECVHSYCEHGG---FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 230
Query: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASC 394
V + F P ++++ AS+ LK+ +L LHGH + R G FAS
Sbjct: 231 AVNGLSF-HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289
Query: 395 AKDQSVRIWRMN 406
D+ V +W+ N
Sbjct: 290 GSDEQVMVWKSN 301
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 3/148 (2%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SPD ++V+AS + W + H V + F P+ T +A G D V+
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSY-CEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
VWD+ H H++ V+ ++FHP L+ SS D+ +++ L + L L H
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS--DSTLKILDLMEGRLLYTLHGH 270
Query: 195 YSAVTSLAFSADGHTMLSSGRDKICIIW 222
T++AFS G S G D+ ++W
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 34.7 bits (78), Expect = 0.36
Identities = 22/82 (26%), Positives = 35/82 (42%)
Query: 551 QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWG 610
+D S + F+GH +V V F QL S D + +W +K H+D V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 611 LHCSRLDDHALTGASDSRVILW 632
++ S +G+ D V +W
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIW 88
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 110 bits (276), Expect = 4e-24
Identities = 83/311 (26%), Positives = 140/311 (45%), Gaps = 25/311 (8%)
Query: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDV 384
L++ F G+ + V V F + S CL V+ ++ S GH D V ++
Sbjct: 11 LERHFKGHRDAVTCVDF-SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 385 FRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444
G L AS ++D++VRIW N G+ HT +V +V +SF VT S D
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFR---AHTATVRSVHFCSDGQSF-VTASDDK 125
Query: 445 TVKLWPL--PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRT 502
TVK+W K L S + H + +P+ +L+ + S D+T
Sbjct: 126 TVKVWATHRQKFLFSLSQ-----------------HINWVRCAKFSPDGRLIVSASDDKT 168
Query: 503 AKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGH 562
KLW + + + H + V F P +A A D T+K+W ++ L+ ++ H
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228
Query: 563 DASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALT 622
A+V ++F G L+++ SD +K+ + + TL H+ + SR ++ +
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 288
Query: 623 GASDSRVILWK 633
G SD +V++WK
Sbjct: 289 GGSDEQVMVWK 299
Score = 97.1 bits (240), Expect = 6e-20
Identities = 76/312 (24%), Positives = 137/312 (43%), Gaps = 18/312 (5%)
Query: 96 QEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVH 155
++ S+ R +K H V + F + LA+G D + VW + + F G V
Sbjct: 7 EDPSLERHFKG-HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 156 LVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGR 215
V F P+ LL S + D +R+W + V AH + V S+ F +DG + +++
Sbjct: 66 CVNF--SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 216 DKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
DK +W AT S+ + V G ++A D T+++W+
Sbjct: 124 DKTVKVW------ATHRQKFLFSLSQHI----NWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335
+S +CV++ + G +T+ + + A D+ + +++ R+ RL + + +S
Sbjct: 174 KSSRECVHSYCEHGG---FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 230
Query: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASC 394
V + F P ++++ AS+ LK+ +L LHGH + R G FAS
Sbjct: 231 AVNGLSF-HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289
Query: 395 AKDQSVRIWRMN 406
D+ V +W+ N
Sbjct: 290 GSDEQVMVWKSN 301
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 3/148 (2%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SPD ++V+AS + W + H V + F P+ T +A G D V+
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSY-CEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
VWD+ H H++ V+ ++FHP L+ SS D+ +++ L + L L H
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS--DSTLKILDLMEGRLLYTLHGH 270
Query: 195 YSAVTSLAFSADGHTMLSSGRDKICIIW 222
T++AFS G S G D+ ++W
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 34.7 bits (78), Expect = 0.36
Identities = 22/82 (26%), Positives = 35/82 (42%)
Query: 551 QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWG 610
+D S + F+GH +V V F QL S D + +W +K H+D V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 611 LHCSRLDDHALTGASDSRVILW 632
++ S +G+ D V +W
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIW 88
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 109 bits (272), Expect = 1e-23
Identities = 150/603 (24%), Positives = 241/603 (39%), Gaps = 79/603 (13%)
Query: 67 EDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLAT 126
+ I+A D+ + +TA LL W Q G KA H + P LLAT
Sbjct: 1719 DGISACLFLSDDTLFLTAFDGLL-ELWDLQHGCRVLQTKA-HQYQITGCCLSPDCRLLAT 1776
Query: 127 GGCDGAVRVWDIVRHYGTHHFRGS-PGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDR 185
G +++WD VR G F+ + P ++ VAFHP+ ++ + + +I + +
Sbjct: 1777 VCLGGCLKLWDTVR--GQLAFQHTYPKSLNCVAFHPEGQ--VIATGSWAGSISFFQVDGL 1832
Query: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLL 245
L A +++ +LAF+ G + D + +W + P AA L
Sbjct: 1833 KVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALF 1892
Query: 246 PEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305
G LTAG+ G ++VW + G+ P L +L+
Sbjct: 1893 ----------LHAGCQLLTAGEDGKVQVWSGSLGR----------PRGHLGSLSLSPALS 1932
Query: 306 VVLTATADHNLLLYEARSLRLQKQFA---GYSEEVLDV-----RFLGPEDSHVVVASNSP 357
V L+ D + Y A +R+ K + G + LDV +L P+ +V +
Sbjct: 1933 VALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGAEDG 1990
Query: 358 CLKVFELQTSACQ---ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW------RMNKA 408
L+ + L+ + Q +L VL L ++ L AS ++D +V++W R +KA
Sbjct: 1991 SLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASASEDFTVQLWPRQLLTRPHKA 2048
Query: 409 GQVMCVAQGSGHTHSVGTVCCSRLKE-SFLVTGSQDCTVKLWPL--PKALLSKNTAPDNG 465
C + GH V CCS + L TG +D ++ W + PK
Sbjct: 2049 EDFPCGTELRGHEGPVS--CCSFSTDGGSLATGGRDRSLLCWDVRTPKT----------- 2095
Query: 466 PILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLW 525
P+L+ + CH + A D LL + S D + LW Q LG F GH+ +
Sbjct: 2096 PVLI--HSFPACHRDWVTGCAWT-KDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVS 2152
Query: 526 CVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSR-------GTQL 578
V + +++ + + S DGT+K+W Q L + H + A G++L
Sbjct: 2153 AV--AAVEEHVVSVSRDGTLKVWDHQGVE-LTSIPAHSGPISHCAAAMEPRAAGQPGSEL 2209
Query: 579 L--SSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVT 636
L + G DG +LW TL H V S LT + D V LW+
Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK 2269
Query: 637 EAE 639
EA+
Sbjct: 2270 EAD 2272
Score = 61.2 bits (147), Expect = 4e-09
Identities = 91/428 (21%), Positives = 167/428 (39%), Gaps = 57/428 (13%)
Query: 74 LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133
LSPD + + RA + + GS +A+ A A P +L +G DG++
Sbjct: 1935 LSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGAEDGSL 1992
Query: 134 RVWDIVRHYGTHHFRGSPGVVHLVAFHPDP------TRLLLFSSATDAAIRVWSLQ---- 183
+ W + S + L++ P ++ LL S++ D +++W Q
Sbjct: 1993 QGWALKEC--------SLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 2044
Query: 184 -----DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFES 238
D C L H V+ +FS DG ++ + GRD+ + WD++ T PV
Sbjct: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVR----TPKTPVL-- 2098
Query: 239 VEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTH- 297
+ + + V+ L ++ G++ +W+ SGQ + GQ L H
Sbjct: 2099 IHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPESGQRL---------GQFLGHQ 2148
Query: 298 ---CTLAHTAGVVLTATADHNLLLYEARSLRLQKQFA-----GYSEEVLDVRFLGPEDSH 349
+A V++ + D L +++ + + L A + ++ R G S
Sbjct: 2149 SAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSE 2208
Query: 350 VVVAS---NSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
++V + + L L GH+ V A V L + ++D SVR+W++
Sbjct: 2209 LLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Query: 407 KAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP 466
K C+ + S +V S V+G+Q + LW KA+ + G
Sbjct: 2269 KEADDTCIPRSSAAVTAVAWA----PDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGA 2324
Query: 467 ILLQAQTT 474
++ + T
Sbjct: 2325 LIWSSAHT 2332
Score = 58.5 bits (140), Expect = 2e-08
Identities = 133/601 (22%), Positives = 220/601 (36%), Gaps = 135/601 (22%)
Query: 3 ETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEV-----ASGAV 57
+T G F+ Y F+ G Q+ TG + +V+ L+V A GA
Sbjct: 1787 DTVRGQLAFQHTYPKSLNCVAFHPEG--QVIATGSWAGSISFFQVDGLKVTKDLGAPGAS 1844
Query: 58 LRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAF 117
+R+L AF++ V+ ++ WAW+EG+ + A H VA F
Sbjct: 1845 IRTL---------AFNVP--GGVVAVGRLDSMVELWAWREGARLAAFPA-HHGFVAAALF 1892
Query: 118 DPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHL-----VAFHPDPTRLLLFSSA 172
L T G DG V+VW RG G + L VA PD R+ + A
Sbjct: 1893 LHAGCQLLTAGEDGKVQVWS----GSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRA 1948
Query: 173 TDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRT 232
IR++ + S A A AV++LA+ + ++S D W L+ C
Sbjct: 1949 D--GIRIYKISSGSQGAQGQALDVAVSALAWLSP-KVLVSGAEDGSLQGWALKEC----- 2000
Query: 233 VPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVW---------EAASGQCVY 283
S+++ LL LG+ + +A + T+++W +A C
Sbjct: 2001 -----SLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055
Query: 284 TQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFL 343
GP ++ C+ + G + T D +LL ++ R+ +
Sbjct: 2056 ELRGHEGP---VSCCSFSTDGGSLATGGRDRSLLCWDVRTPK------------------ 2094
Query: 344 GPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
+ V++ S C H D V + K L SC+ D SV +W
Sbjct: 2095 ----TPVLIHSFPAC----------------HRDWVTGC-AWTKDNLLISCSSDGSVGLW 2133
Query: 404 RMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPD 463
++GQ + Q GH +V V E +V+ S+D T+K+W L+ A
Sbjct: 2134 DP-ESGQRL--GQFLGHQSAVSAVAAV---EEHVVSVSRDGTLKVWDHQGVELTSIPA-H 2186
Query: 464 NGPI-----------------------------------LLQAQT-TQRCHDKDINSVAI 487
+GPI LL QT T H + + A+
Sbjct: 2187 SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAV 2246
Query: 488 APNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKL 547
+ L+ T S+D + +LW +P+ + V ++P + + + G + L
Sbjct: 2247 SETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELIL 2306
Query: 548 W 548
W
Sbjct: 2307 W 2307
Score = 49.3 bits (116), Expect = 1e-05
Identities = 92/434 (21%), Positives = 160/434 (36%), Gaps = 79/434 (18%)
Query: 101 TRLWKAI----------HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGS 150
TRLW + H+ PV A TS L+ T DG+VR+W + + S
Sbjct: 2220 TRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRS 2279
Query: 151 PGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM 210
V VA+ PD + + + A + + +W + AV TA + HT
Sbjct: 2280 SAAVTAVAWAPDGSMAVSGNQAGE--LILW----QEAKAVATAQAPGHIGALIWSSAHTF 2333
Query: 211 LSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGT 270
D+ W ++ + + P S+ +L E+ LGV L L G
Sbjct: 2334 FVLSADEKISEWQVKLRKG--SAPGNLSLHLNRILQED----LGV----LTSLDWAPDGH 2383
Query: 271 LRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG-VVLTATADHNLLLYEAR-----SL 324
+ A + + + PG + ++T ++L+ ++ + + + + S
Sbjct: 2384 FLILAKADLKLLCMK-----PGDAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSF 2438
Query: 325 RLQKQFAGYSEEV-LDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALD 383
QK+ + E + D+ P + + + P S L +D +L
Sbjct: 2439 LRQKESGEFEERLNFDINLENPSRTLISITQAKP--------ESESSFLCASSDGIL--- 2487
Query: 384 VFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQD 443
W A C+ + W G + + T + GT S +ES S D
Sbjct: 2488 -----WNLAKCSPEGE---W---TTGNMWQKKANTPETQTPGT-DPSTCRESDASMDS-D 2534
Query: 444 CTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTA 503
++ P P L+ + ++ H + ++ + P +LL T S+DR
Sbjct: 2535 ASMDSEPTPH---------------LKTRQRRKIHSGSVTALHVLP--ELLVTASKDRDV 2577
Query: 504 KLWALPQCQLLGVF 517
KLW P QLLG+F
Sbjct: 2578 KLWERPSMQLLGLF 2591
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 527 VQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
V FS Q A +A+GT+ L L+ + K+ + F+S T L++ DGL
Sbjct: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGL 1740
Query: 587 VKLWTIKNNECVRTLDAHEDKVWG 610
++LW +++ V AH+ ++ G
Sbjct: 1741 LELWDLQHGCRVLQTKAHQYQITG 1764
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 107 bits (267), Expect = 4e-23
Identities = 75/309 (24%), Positives = 145/309 (46%), Gaps = 21/309 (6%)
Query: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILH-GHTDIVLALDV 384
L++ F G+ + + L P + AS L ++ + A + GH D+V ++
Sbjct: 10 LERYFKGHKAAITSLD-LSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68
Query: 385 FRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444
G L AS ++D++VR+W +K G+ ++ HT V +V S FL T S+D
Sbjct: 69 SPHGNLLASASRDRTVRLWIPDKRGKF---SEFKAHTAPVRSVDFSA-DGQFLATASEDK 124
Query: 445 TVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAK 504
++K+W + + + H + +P+ +L+ + S+D+T K
Sbjct: 125 SIKVWSMYRQRFLYSLYR---------------HTHWVRCAKFSPDGRLIVSCSEDKTIK 169
Query: 505 LWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDA 564
+W Q + FS V F+P +A+A +D T+K+W ++ L+ ++ H
Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
Query: 565 SVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGA 624
V ++F G L+++ SDG +K+ + + TL H V+ + S+ + +G
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
Query: 625 SDSRVILWK 633
+D++V+LW+
Sbjct: 290 ADTQVLLWR 298
Score = 93.2 bits (230), Expect = 9e-19
Identities = 72/301 (23%), Positives = 129/301 (42%), Gaps = 19/301 (6%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
H A + ++ P LAT D + +W+ H + + G VV V F P L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN--L 74
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
L S++ D +R+W R + AH + V S+ FSADG + ++ DK +W +
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 228 QATRTVPVFES-VEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQA 286
+ ++ V A P+ G ++ + T+++W+ + QCV +
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPD-----------GRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
Query: 287 QPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPE 346
G + + +A +D + +++ R +L + + +S V + F P
Sbjct: 184 DSVG---FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF-HPS 239
Query: 347 DSHVVVASNSPCLKVFE-LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRM 405
++++ AS+ LK+ + L+ L GHT V + + G LFAS D V +WR
Sbjct: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Query: 406 N 406
N
Sbjct: 300 N 300
Score = 81.6 bits (200), Expect = 3e-15
Identities = 91/352 (25%), Positives = 142/352 (40%), Gaps = 58/352 (16%)
Query: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAI-HTAPVATMAFDPTSTLLATG 127
IT+ DLSP+ + L TAS L W ++ + R ++ + H V ++ F P LLA+
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHA--RAYRYVGHKDVVTSVQFSPHGNLLASA 78
Query: 128 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 187
D VR+W + F+ V V F D L +++ D +I+VWS+ +
Sbjct: 79 SRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ--FLATASEDKSIKVWSMYRQRF 136
Query: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD------------------------ 223
L L H V FS DG ++S DK IWD
Sbjct: 137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNP 196
Query: 224 ----LQSCQATRTVPVFESVEAAVLLPEEPVSQLGVK-----SPGLYFLTAGDQGTLRVW 274
+ S + +TV V++ V LL V GV G Y +TA GTL++
Sbjct: 197 SGTCIASAGSDQTVKVWD-VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255
Query: 275 EAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTAT--ADHNLLLYEAR---------- 322
+ G+ +YT GP T++ + G L A+ AD +LL+
Sbjct: 256 DLLEGRLIYTLQGHTGP-----VFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLT 310
Query: 323 SLRLQKQFAGYSEEVLDV--RFLGPEDSHVVVASNSPCLKVFELQTSACQIL 372
L++ +LD+ R P + V +P L+V +LQ S ++
Sbjct: 311 KRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPPVM 362
Score = 34.3 bits (77), Expect = 0.47
Identities = 21/84 (25%), Positives = 36/84 (42%)
Query: 549 ALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKV 608
A +D + F+GH A++ + G QL ++ D + LW K + H+D V
Sbjct: 4 ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63
Query: 609 WGLHCSRLDDHALTGASDSRVILW 632
+ S + + + D V LW
Sbjct: 64 TSVQFSPHGNLLASASRDRTVRLW 87
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 107 bits (266), Expect = 6e-23
Identities = 64/225 (28%), Positives = 108/225 (48%), Gaps = 10/225 (4%)
Query: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATG 497
VTG D +VK W L+ + + Q +T Q D+D+ V+ +PN KLLA
Sbjct: 512 VTGGADKSVKFWDFE--LVKDENSTQKRLSVKQTRTLQL--DEDVLCVSYSPNQKLLAVS 567
Query: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLK 557
D T K++ + + GH+ + C+ S ++AT SAD +K+W L C K
Sbjct: 568 LLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK 627
Query: 558 TFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLD 617
+ HD SV+ + FV + ++G D +K W E ++TL+ H ++W L S
Sbjct: 628 SLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSG 687
Query: 618 DHALTGASDSRVILWKD------VTEAEQAEEQARQEEQVVRQQE 656
D+ ++ + D + LW+ + E + E +A EE V ++ +
Sbjct: 688 DYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQ 732
Score = 84.0 bits (206), Expect = 5e-16
Identities = 43/174 (24%), Positives = 91/174 (52%), Gaps = 1/174 (0%)
Query: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
+++ + +P+ LA G +D + ++++L + F+GH+ + +++ + LA+
Sbjct: 66 QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125
Query: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
S D I +W + + S L +GH ++ + F+ L++SG D +VK W + C +
Sbjct: 126 SKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFK 185
Query: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVR 653
T+ H +VWGL + +TGASDS + +W D+ ++ E+ + + ++
Sbjct: 186 TMVGHRTEVWGLVLLSEEKRLITGASDSELRVW-DIAYLQEIEDPEEPDPKKIK 238
Score = 75.9 bits (185), Expect = 1e-13
Identities = 131/617 (21%), Positives = 216/617 (35%), Gaps = 99/617 (16%)
Query: 57 VLRSLEQEDQEDITAFDLSPDNEVLVTASR--ALLLAQWAWQEGSVTRLWKAIHTAPVAT 114
+L+ L+QE +T SPD L ++ + EG+VT H A + T
Sbjct: 60 ILQGLKQE----VTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG---HKAAITT 112
Query: 115 MAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATD 174
+ +D LA+G D + VWD++ G + +G + F + + LL +S D
Sbjct: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLRE--KNLLVTSGKD 170
Query: 175 AAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP 234
++ W L + C + H + V L ++ +++ D +WD+ Q
Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIED-- 228
Query: 235 VFESVEAAVLLPEEP-VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ---CVYTQAQPPG 290
PEEP ++ SPG+ + G EA + C +
Sbjct: 229 -----------PEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMRE 277
Query: 291 PGQELTHCTLAHTAGVVLTATADHNLLLY-----------------EARSLRLQKQFAGY 333
+ + + T ++ D L L+ +AR G
Sbjct: 278 GRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGE 337
Query: 334 SE--EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL--DVFRKGW 389
E EV L E V S +K F+L S HG V L ++
Sbjct: 338 EEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSP----HGELKAVFLLQNNLVELYS 393
Query: 390 LFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
L S Q VR R+ GH V T+ S ++ V + ++K+W
Sbjct: 394 LNPSLPTPQPVRTSRITI----------GGHRSDVRTLSFS--SDNIAVLSAAADSIKIW 441
Query: 450 PLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP 509
+++T LQ T C + P D+ + G++ +L+ L
Sbjct: 442 -------NRST--------LQCIRTMTCEYALCS--FFVPGDRQVVIGTKTGKLQLYDLA 484
Query: 510 QCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGH------- 562
LL H LW + SP + T AD ++K W DF +K
Sbjct: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW---DFELVKDENSTQKRLSVK 541
Query: 563 -------DASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSR 615
D VL V++ L S D VK++ + + +L H+ V + S
Sbjct: 542 QTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISH 601
Query: 616 LDDHALTGASDSRVILW 632
TG++D V +W
Sbjct: 602 DGALIATGSADRNVKIW 618
Score = 66.2 bits (160), Expect = 1e-10
Identities = 106/519 (20%), Positives = 195/519 (37%), Gaps = 63/519 (12%)
Query: 161 PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
P P L L D +IR++SL H +A+T+L + G + S +D I
Sbjct: 73 PSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDII 132
Query: 221 IWD-LQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASG 279
+WD + R +++ A+ L E+ + +T+G ++ W+ +
Sbjct: 133 VWDVINESGLYRLKGHKDAITQALFLREKNL-----------LVTSGKDTMVKWWDLDTQ 181
Query: 280 QCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLD 339
C T G E+ L ++T +D L +++ Y +E+ D
Sbjct: 182 HCFKTMV---GHRTEVWGLVLLSEEKRLITGASDSELRVWDI----------AYLQEIED 228
Query: 340 VRFLGPEDSHVVVASNSPCLK-VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQ 398
P+ + +SP ++ E + A + D +L+ RK +D+
Sbjct: 229 PEEPDPKK----IKGSSPGIQDTLEAEDGAFETDEAPEDRILSC---RKAGSIMREGRDR 281
Query: 399 SVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSK 458
V + ++K G+++ T SV + C K+ + D +K KA L
Sbjct: 282 VVNL-AVDKTGRILACHG----TDSVLELFCILSKKE--IQKKMDKKMKK-ARKKAKLHS 333
Query: 459 NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFS 518
+ + P + + Q + N A S K L Q L+ ++S
Sbjct: 334 SKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYS 393
Query: 519 -------------------GHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559
GHR + + FS + + +A+AD +IK+W C++T
Sbjct: 394 LNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM 452
Query: 560 EGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDH 619
A L FV Q++ G ++L+ + + + T+DAH+ +W + S
Sbjct: 453 TCEYA--LCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRG 510
Query: 620 ALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELD 658
+TG +D V W ++ Q R + R +LD
Sbjct: 511 FVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLD 549
Score = 58.9 bits (141), Expect = 2e-08
Identities = 74/334 (22%), Positives = 138/334 (41%), Gaps = 48/334 (14%)
Query: 185 RSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVL 244
R+ + H S V +L+FS+D +LS+ D I I W+ + Q RT+ E +
Sbjct: 405 RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKI-WNRSTLQCIRTMTC-EYALCSFF 462
Query: 245 LPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTA 304
+P + +G K+ G L++++ ASG + T G L +L+
Sbjct: 463 VPGDRQVVIGTKT-----------GKLQLYDLASGNLLETIDAHDGA---LWSMSLSPDQ 508
Query: 305 GVVLTATADHNLLLYEARSLR-----------LQKQFAGYSEEVLDVRFLGPEDSHVVVA 353
+T AD ++ ++ ++ Q + E+VL V + P + V+
Sbjct: 509 RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSY-SPNQKLLAVS 567
Query: 354 SNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVM 412
+K+F + T + L+GH V+ +D+ G L A+ + D++V+IW ++
Sbjct: 568 LLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD--- 624
Query: 413 CVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQ 472
C H SV + K T +D +K W K +
Sbjct: 625 CHKSLFAHDDSVMYLQFVP-KSHLFFTAGKDHKIKQWDADK---------------FEHI 668
Query: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
T H ++I +A++P+ + + S D++ +LW
Sbjct: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Score = 51.2 bits (121), Expect = 4e-06
Identities = 49/242 (20%), Positives = 97/242 (40%), Gaps = 27/242 (11%)
Query: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQ----EGSVT 101
++ + ++ASG +L +++ D + + LSPD VT + W ++ E S
Sbjct: 477 KLQLYDLASGNLLETIDAHDGA-LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQ 535
Query: 102 RLWKAIHTAP------VATMAFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGV 153
+ T V +++ P LLA D V+++ D ++ + + + P
Sbjct: 536 KRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP-- 593
Query: 154 VHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSS 213
++ L+ + + D +++W L C L AH +V L F H ++
Sbjct: 594 --VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTA 651
Query: 214 GRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRV 273
G+D WD + +T+ + + L V G Y +++ +LR+
Sbjct: 652 GKDHKIKQWDADKFEHIQTLEGH----------HQEIWCLAVSPSGDYVVSSSHDKSLRL 701
Query: 274 WE 275
WE
Sbjct: 702 WE 703
Score = 47.0 bits (110), Expect = 7e-05
Identities = 57/313 (18%), Positives = 121/313 (38%), Gaps = 33/313 (10%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
H + V T++F + + + D ++++W+ R L +F R +
Sbjct: 414 HRSDVRTLSFSSDNIAVLSAAAD-SIKIWN---RSTLQCIRTMTCEYALCSFFVPGDRQV 469
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-- 225
+ + T ++++ L + L + AH A+ S++ S D ++ G DK WD +
Sbjct: 470 VIGTKT-GKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELV 528
Query: 226 ----------SCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
S + TRT+ + E V P + + + + + TL+ +
Sbjct: 529 KDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVD---TLKFFL 585
Query: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335
+ G + + ++H ++ T +AD N+ ++ K + +
Sbjct: 586 SLYGHKL-----------PVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDD 634
Query: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASC 394
V+ ++F+ P+ A +K ++ Q L GH + L V G S
Sbjct: 635 SVMYLQFV-PKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSS 693
Query: 395 AKDQSVRIWRMNK 407
+ D+S+R+W +
Sbjct: 694 SHDKSLRLWERTR 706
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/92 (19%), Positives = 41/92 (44%)
Query: 547 LWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHED 606
+W L+ + +G V + G L DG ++++++ + E T + H+
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 607 KVWGLHCSRLDDHALTGASDSRVILWKDVTEA 638
+ L +L +G+ D+ +I+W + E+
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINES 140
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 105 bits (263), Expect = 1e-22
Identities = 76/279 (27%), Positives = 128/279 (45%), Gaps = 24/279 (8%)
Query: 358 CLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQ 416
CL V+ ++ S GH D V ++ G L AS ++D++VRIW N G+
Sbjct: 4 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR- 62
Query: 417 GSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPL--PKALLSKNTAPDNGPILLQAQTT 474
HT +V +V +SF VT S D TVK+W K L S +
Sbjct: 63 --AHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQ-------------- 105
Query: 475 QRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQ 534
H + +P+ +L+ + S D+T KLW + + + H + V F P
Sbjct: 106 ---HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162
Query: 535 VLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
+A A D T+K+W ++ L+ ++ H A+V ++F G L+++ SD +K+ +
Sbjct: 163 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222
Query: 595 NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
+ TL H+ + SR ++ +G SD +V++WK
Sbjct: 223 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
Score = 93.6 bits (231), Expect = 7e-19
Identities = 62/231 (26%), Positives = 103/231 (44%), Gaps = 19/231 (8%)
Query: 397 DQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALL 456
D + +W M + + +GH +V V S L +GS+D TV++W
Sbjct: 2 DSCLMVWHMKPQSRAY---RFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIWV------ 51
Query: 457 SKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGV 516
P + T R H + SV + + T S D+T K+WA + + L
Sbjct: 52 ---------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 102
Query: 517 FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGT 576
S H + C +FSP +++ +AS D T+KLW C+ ++ H V V F GT
Sbjct: 103 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162
Query: 577 QLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDS 627
+ ++G D VK+W ++ + ++ H V GL ++ +T +SDS
Sbjct: 163 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213
Score = 88.2 bits (217), Expect = 3e-17
Identities = 67/278 (24%), Positives = 122/278 (43%), Gaps = 17/278 (6%)
Query: 130 DGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLA 189
D + VW + + F G V V F P+ LL S + D +R+W +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNF--SPSGHLLASGSRDKTVRIWVPNVKGEST 59
Query: 190 VLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEP 249
V AH + V S+ F +DG + +++ DK +W AT S+ +
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW------ATHRQKFLFSLSQHI----NW 109
Query: 250 VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLT 309
V G ++A D T+++W+ +S +CV++ + G +T+ + +
Sbjct: 110 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---HGGFVTYVDFHPSGTCIAA 166
Query: 310 ATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFEL-QTSA 368
A D+ + +++ R+ RL + + +S V + F P ++++ AS+ LK+ +L +
Sbjct: 167 AGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF-HPSGNYLITASSDSTLKILDLMEGRL 225
Query: 369 CQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
LHGH + R G FAS D+ V +W+ N
Sbjct: 226 LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 3/148 (2%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SPD ++V+AS + W + H V + F P+ T +A G D V+
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSY-CEHGGFVTYVDFHPSGTCIAAAGMDNTVK 174
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
VWD+ H H++ V+ ++FHP L+ SS D+ +++ L + L L H
Sbjct: 175 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS--DSTLKILDLMEGRLLYTLHGH 232
Query: 195 YSAVTSLAFSADGHTMLSSGRDKICIIW 222
T++AFS G S G D+ ++W
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 61.2 bits (147), Expect = 4e-09
Identities = 56/246 (22%), Positives = 95/246 (38%), Gaps = 37/246 (15%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
H V + F P+ LLA+G D VR+W + FR V V F D +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+++ D ++VW+ + L L+ H + V FS DG ++S+ DK +WD S
Sbjct: 82 --TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 228 QAT----------------------------RTVPVFESVEAAVL----LPEEPVSQLGV 255
+ TV V++ +L L V+ L
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
Query: 256 KSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
G Y +TA TL++ + G+ +YT GP T + T + +D
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPA---TTVAFSRTGEYFASGGSDEQ 256
Query: 316 LLLYEA 321
++++++
Sbjct: 257 VMVWKS 262
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 77 DNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVW 136
D + VTAS + WA + H V F P L+ + D V++W
Sbjct: 76 DGQSFVTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 137 DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYS 196
D H + G V V FHP T + ++ D ++VW ++ L H +
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGT--CIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 197 AVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVK 256
AV L+F G+ ++++ D I DL + T+ + P + +
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG----------PATTVAFS 242
Query: 257 SPGLYFLTAGDQGTLRVWEA 276
G YF + G + VW++
Sbjct: 243 RTGEYFASGGSDEQVMVWKS 262
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 105 bits (262), Expect = 2e-22
Identities = 71/271 (26%), Positives = 117/271 (43%), Gaps = 19/271 (7%)
Query: 370 QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCC 429
+IL GH V + SC++D S+R W + G GH + V +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL---GSFTNTVLYQGHAYPVWDLDI 392
Query: 430 SRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAP 489
S F +GS D T +LW + P+ + A H D++ V P
Sbjct: 393 SPYSLYF-ASGSHDRTARLWSFDRTY----------PLRIYAG-----HLADVDCVKFHP 436
Query: 490 NDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWA 549
N LATGS D+T +LW+ Q + +F+GHR + + FSP + LA+A D +KLW
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
Query: 550 LQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVW 609
L + K GH ++ + F + S+ D V++W I+N C D ++
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
Query: 610 GLHCSRLDDHALTGASDSRVILWKDVTEAEQ 640
G++ ++ + ++L +T+ Q
Sbjct: 557 GVYTGQMSNVLSVQFMACNLLLVTGITQENQ 587
Score = 104 bits (260), Expect = 3e-22
Identities = 78/304 (25%), Positives = 136/304 (44%), Gaps = 38/304 (12%)
Query: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIV---LALDVFRKGWL 390
+E++L+ + P+ + ++ C+K++ L++ + D+ LA D+ +
Sbjct: 267 TEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEE--- 323
Query: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRL--KESFLVTGSQDCTVKL 448
D+ + AG M + +G G V +R S L++ S+D +++
Sbjct: 324 ----EDDED------DNAGTEMKILRGH-----CGPVYSTRFLADSSGLLSCSEDMSIRY 368
Query: 449 WPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWAL 508
W L NT G H + + I+P A+GS DRTA+LW+
Sbjct: 369 WDLGSFT---NTVLYQG------------HAYPVWDLDISPYSLYFASGSHDRTARLWSF 413
Query: 509 PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLK 568
+ L +++GH + CV+F P LAT S D T++LW+ Q + ++ F GH VL
Sbjct: 414 DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS 473
Query: 569 VAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSR 628
+AF G L S+G D +KLW + + + L H D + L S + + D+
Sbjct: 474 LAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNS 533
Query: 629 VILW 632
V +W
Sbjct: 534 VRVW 537
Score = 79.7 bits (195), Expect = 1e-14
Identities = 72/274 (26%), Positives = 109/274 (39%), Gaps = 32/274 (11%)
Query: 61 LEQEDQED----------------ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLW 104
LE+ED ED + + D+ L++ S + + W + T L+
Sbjct: 321 LEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380
Query: 105 KAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
+ H PV + P S A+G D R+W R Y + G V V FHP+
Sbjct: 381 QG-HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L + +TD +R+WS Q + + + T H V SLAFS +G + S+G D+ +WDL
Sbjct: 440 YLA--TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497
Query: 225 QSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284
S T + + L P S L +A ++RVW+ + Y
Sbjct: 498 AS--GTLYKELRGHTDNITSLTFSPDSGL--------IASASMDNSVRVWDIRN---TYC 544
Query: 285 QAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
A G EL + V+ NLLL
Sbjct: 545 SAPADGSSSELVGVYTGQMSNVLSVQFMACNLLL 578
Score = 63.2 bits (152), Expect = 1e-09
Identities = 71/291 (24%), Positives = 111/291 (38%), Gaps = 27/291 (9%)
Query: 114 TMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173
T P S LLA G + +++W + + + P V + H L
Sbjct: 273 TAEISPDSKLLAAGFDNSCIKLWSL----RSKKLKSEPHQVDVSRIHLACDILEEEDDED 328
Query: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTV 233
D A + + +L H V S F AD +LS D WDL S T TV
Sbjct: 329 DNA--------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS--FTNTV 378
Query: 234 PVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQ 293
+++ PV L + LYF + T R+W S Y G
Sbjct: 379 -LYQG-------HAYPVWDLDISPYSLYFASGSHDRTARLW---SFDRTYPLRIYAGHLA 427
Query: 294 ELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA 353
++ + + T + D + L+ A+ + F G+ VL + F P ++ A
Sbjct: 428 DVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF-SPNGKYLASA 486
Query: 354 SNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
LK+++L + + L GHTD + +L L AS + D SVR+W
Sbjct: 487 GEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 104 bits (260), Expect = 3e-22
Identities = 61/208 (29%), Positives = 95/208 (45%), Gaps = 15/208 (7%)
Query: 435 SFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLL 494
++L++ S+D TV+LW L + H+ + +P
Sbjct: 556 NYLLSSSEDGTVRLWSLQT---------------FTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 495 ATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFS 554
+G DR A+LWA Q L +F+GH + C +F P +AT SAD T++LW + + +
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 555 CLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCS 614
C++ F GH + + F G L + +DG V LW I + V L H D V L S
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 615 RLDDHALTGASDSRVILWKDVTEAEQAE 642
R + +G+ D+ V LW + E E
Sbjct: 721 RDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 97.4 bits (241), Expect = 5e-20
Identities = 61/214 (28%), Positives = 91/214 (42%), Gaps = 16/214 (7%)
Query: 435 SFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPI----------LLQAQTTQRC-----H 478
S + G D TV++W + PK L S A D I ++ +T H
Sbjct: 483 SLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGH 542
Query: 479 DKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLAT 538
+ + +P+ L + S+D T +LW+L L + GH +W QFSP +
Sbjct: 543 SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVS 602
Query: 539 ASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECV 598
D +LWA + L+ F GH A V F + + +D V+LW + N CV
Sbjct: 603 GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV 662
Query: 599 RTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
R H+ + L S TGA+D RV+LW
Sbjct: 663 RIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 73.9 bits (180), Expect = 5e-13
Identities = 49/173 (28%), Positives = 69/173 (39%), Gaps = 3/173 (1%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SP V+ + WA R++ A H A V F P S +ATG D VR
Sbjct: 594 SPYGYYFVSGGHDRVARLWATDHYQPLRIF-AGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
+WD++ F G G +H + F P+ L + ATD + +W + + L H
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 195 YSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 247
V SL FS DG + S D +WD F + + LPE
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPE 763
Score = 68.2 bits (165), Expect = 3e-11
Identities = 62/239 (25%), Positives = 97/239 (40%), Gaps = 27/239 (11%)
Query: 149 GSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGH 208
G G V+ +F PD R L SS+ D +R+WSLQ +CL H V FS G+
Sbjct: 541 GHSGPVYGASFSPD--RNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 209 TMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE-EPVSQLGVKSPGLYFLTAGD 267
+S G D++ +W Q R +F A V P S Y T
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLR---IFAGHLADVNCTRFHPNSN--------YVATGSA 647
Query: 268 QGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQ 327
T+R+W+ +G CV GP L T + + T D +LL++ +
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSL---TFSPNGRFLATGATDGRVLLWDIGHGLMV 704
Query: 328 KQFAGYSEEVLDVRFLGPEDSHVVVASNS-------PCLKVFE-LQTSACQILHGHTDI 378
+ G+++ V +RF D ++ + + +K FE L+T GH ++
Sbjct: 705 GELKGHTDTVCSLRF--SRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINL 761
Score = 67.4 bits (163), Expect = 5e-11
Identities = 38/150 (25%), Positives = 67/150 (44%), Gaps = 3/150 (2%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SPD L+++S + W+ Q + +K H PV F P +GG D R
Sbjct: 552 SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG-HNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
+W + F G V+ FHP+ + + + D +R+W + + +C+ + T H
Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSN--YVATGSADRTVRLWDVLNGNCVRIFTGH 668
Query: 195 YSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
+ SL FS +G + + D ++WD+
Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
Score = 65.1 bits (157), Expect = 3e-10
Identities = 74/297 (24%), Positives = 113/297 (38%), Gaps = 44/297 (14%)
Query: 121 STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVW 180
S+L+A G D VRVW + +P + V D + L+ + D R+
Sbjct: 482 SSLIAGGFADSTVRVWSV-----------TPKKLRSVKQASDLS--LIDKESDDVLERIM 528
Query: 181 SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVE 240
+ S L +L H V +FS D + +LSS D +W LQ+
Sbjct: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL---------- 578
Query: 241 AAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTL 300
PV G YF++ G R+W Q + A +CT
Sbjct: 579 VGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD----VNCTR 634
Query: 301 AH-TAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRF--------LGPEDSHVV 351
H + V T +AD + L++ + + F G+ + + F G D V+
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 694
Query: 352 VASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKA 408
+ L V EL+ GHTD V +L R G + AS + D +VR+W KA
Sbjct: 695 LWDIGHGLMVGELK--------GHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/142 (23%), Positives = 52/142 (36%), Gaps = 31/142 (21%)
Query: 522 RGLWCVQFSPMDQVLATASADGTIKLWAL------------------------------- 550
+GL V + ++A AD T+++W++
Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDE 530
Query: 551 QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWG 610
+ S LK GH V +F LLSS DG V+LW+++ C+ H VW
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 611 LHCSRLDDHALTGASDSRVILW 632
S + ++G D LW
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLW 612
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 103 bits (256), Expect = 8e-22
Identities = 75/304 (24%), Positives = 134/304 (44%), Gaps = 19/304 (6%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
HT V+++ F P LA+ D + +W G + VA+ D +RL+
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
S++ D +++W ++ CL L H + V F+ + ++S D+ IW++++
Sbjct: 100 --SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ +T+ +PVS + G ++ G R+W+AASGQC+ T
Sbjct: 158 KCLKTLSAH----------SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVD 207
Query: 288 PPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEE--VLDVRFLGP 345
P ++ + +LTAT D+ L L++ R K + G+ E + F
Sbjct: 208 DDNP--PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265
Query: 346 EDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASCA--KDQSVRI 402
+V S + ++ LQT Q L GHTD+V++ L AS A D+++++
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKL 325
Query: 403 WRMN 406
W N
Sbjct: 326 WMSN 329
Score = 92.0 bits (227), Expect = 2e-18
Identities = 60/215 (27%), Positives = 100/215 (46%), Gaps = 17/215 (7%)
Query: 419 GHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCH 478
GHT +V +V S E +L + S D + +W G + + T H
Sbjct: 39 GHTEAVSSVKFSPNGE-WLASSSADRLIIIW---------------GAYDGKYEKTLYGH 82
Query: 479 DKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLAT 538
+ +I+ VA + + L + S D+T KLW + + L GH ++C F+P ++ +
Sbjct: 83 NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS 142
Query: 539 ASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECV 598
S D T+K+W ++ CLKT H V V F G+ ++S DGL ++W + +C+
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 599 RTL-DAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
+TL D V + S + LT D+ + LW
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 91.3 bits (225), Expect = 3e-18
Identities = 82/342 (23%), Positives = 150/342 (43%), Gaps = 39/342 (11%)
Query: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
A + L+++A+ + + E + L+ G++E V V+F P + +S + ++
Sbjct: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKF-SPNGEWLASSSADRLIIIWG 69
Query: 364 LQTSACQ-ILHGH----TDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGS 418
+ L+GH +D+ + D R S + D+++++W + C+
Sbjct: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSR----LVSASDDKTLKLWDVRSG---KCLKTLK 122
Query: 419 GHTHSVGTVCCS-RLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC 477
GH++ V CC+ + +++GS D TVK+W + K T
Sbjct: 123 GHSNYV--FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLK---------------TLSA 165
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLW--ALPQCQLLGVFSGHRRGLWCVQFSPMDQV 535
H +++V + L+ +GS D ++W A QC L + + V+FSP +
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC-LKTLVDDDNPPVSFVKFSPNGKY 224
Query: 536 LATASADGTIKLWALQDFSCLKTFEGHDAS---VLKVAFVSRGTQLLSSGSDGLVKLWTI 592
+ TA+ D T+KLW CLKT+ GH + V+ G ++S D LV +W +
Sbjct: 225 ILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Query: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGA--SDSRVILW 632
+ E V+ L H D V C ++ + A +D + LW
Sbjct: 285 QTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 75.5 bits (184), Expect = 2e-13
Identities = 40/142 (28%), Positives = 77/142 (54%)
Query: 492 KLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ 551
+L + S +++ ++ P L GH + V+FSP + LA++SAD I +W
Sbjct: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
Query: 552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGL 611
D KT GH+ + VA+ S ++L+S+ D +KLW +++ +C++TL H + V+
Sbjct: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
Query: 612 HCSRLDDHALTGASDSRVILWK 633
+ + + ++G+ D V +W+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWE 153
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 2/134 (1%)
Query: 49 ILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIH 108
I + ASG L++L +D ++ SP+ + ++TA+ L W + G + +
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
Query: 109 TAPVATMA-FDPT-STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166
A F T + +G D V +W++ +G VV A HP +
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312
Query: 167 LLFSSATDAAIRVW 180
+ D I++W
Sbjct: 313 ASAALENDKTIKLW 326
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 102 bits (255), Expect = 1e-21
Identities = 72/302 (23%), Positives = 132/302 (43%), Gaps = 19/302 (6%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
HT V+++ F P LA+ D +++W G + VA+ D L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN--L 101
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
L S++ D +++W + CL L H + V F+ + ++S D+ IWD+++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ +T+P +PVS + G +++ G R+W+ ASGQC+ T
Sbjct: 162 KCLKTLPAH----------SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 288 PPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEE--VLDVRFLGP 345
P ++ + +L AT D+ L L++ + K + G+ E + F
Sbjct: 212 DDNP--PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 346 EDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASCA--KDQSVRI 402
+V S + ++ LQT Q L GHTD+V++ + AS A D+++++
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
Query: 403 WR 404
W+
Sbjct: 330 WK 331
Score = 97.8 bits (242), Expect = 3e-20
Identities = 49/155 (31%), Positives = 81/155 (52%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H K ++SV +PN + LA+ S D+ K+W + SGH+ G+ V +S +L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+AS D T+K+W + CLKT +GH V F + ++S D V++W +K +C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 598 VRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
++TL AH D V +H +R ++ + D +W
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 97.1 bits (240), Expect = 6e-20
Identities = 67/274 (24%), Positives = 129/274 (47%), Gaps = 20/274 (7%)
Query: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGG 128
+++ SP+ E L ++S L+ W +G + H ++ +A+ S LL +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNLLVSAS 106
Query: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCL 188
D +++WD+ +G V F+P L+ S + D ++R+W ++ CL
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTGKCL 164
Query: 189 AVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEE 248
L AH V+++ F+ DG ++SS D +C IWD S Q +T+ +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL---------IDDDNP 215
Query: 249 PVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAH---TAG 305
PVS + G Y L A TL++W+ + G+C+ T G E +C A+ T G
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---GHKNE-KYCIFANFSVTGG 271
Query: 306 VVLTATADHNLL-LYEARSLRLQKQFAGYSEEVL 338
+ + ++ NL+ ++ ++ + ++ G+++ V+
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/216 (26%), Positives = 99/216 (45%), Gaps = 17/216 (7%)
Query: 418 SGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC 477
+GHT +V +V S E +L + S D +K+W K +
Sbjct: 42 AGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISG--------------- 85
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H I+ VA + + LL + S D+T K+W + + L GH ++C F+P ++
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+ S D ++++W ++ CLKT H V V F G+ ++SS DGL ++W + +C
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 598 VRTL-DAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
++TL D V + S + L D+ + LW
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 87.8 bits (216), Expect = 4e-17
Identities = 80/323 (24%), Positives = 141/323 (43%), Gaps = 43/323 (13%)
Query: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV-------FELQTSACQILHGHTDI 378
L+ AG+++ V V+F P + +S +K+ FE S ++ G +D+
Sbjct: 37 LKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL--GISDV 93
Query: 379 VLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKES-FL 437
+ D L S + D++++IW ++ C+ GH++ V CC+ +S +
Sbjct: 94 AWSSD----SNLLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYV--FCCNFNPQSNLI 144
Query: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATG 497
V+GS D +V++W + K T H +++V + L+ +
Sbjct: 145 VSGSFDESVRIWDVKTGKCLK---------------TLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 498 SQDRTAKLW--ALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSC 555
S D ++W A QC L + + V+FSP + + A+ D T+KLW C
Sbjct: 190 SYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 556 LKTFEGHDAS---VLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
LKT+ GH + V+ G ++S D LV +W ++ E V+ L H D V
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Query: 613 CSRLDDHALTGA--SDSRVILWK 633
C ++ + A +D + LWK
Sbjct: 309 CHPTENIIASAALENDKTIKLWK 331
Score = 76.3 bits (186), Expect = 1e-13
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 4/144 (2%)
Query: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
P AT S+ K P L +GH + + V+FSP + LA++SAD IK+W
Sbjct: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Query: 549 ALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKV 608
D KT GH + VA+ S L+S+ D +K+W + + +C++TL H + V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 609 WGLHCSRLDDHALTGASDSRVILW 632
+ + + + ++G+ D V +W
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIW 156
Score = 73.2 bits (178), Expect = 9e-13
Identities = 68/323 (21%), Positives = 139/323 (43%), Gaps = 40/323 (12%)
Query: 191 LTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPV 250
L H AV+S+ FS +G + SS DK+ IW + +T+ + +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL----------GI 90
Query: 251 SQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTA 310
S + S ++A D TL++W+ +SG+C+ T G + C + ++++
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNFNPQSNLIVSG 147
Query: 311 TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC- 369
+ D ++ +++ ++ + K +S+ V V F + S +V +S ++++ + C
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 370 -QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVC 428
++ V + G + D ++++W +K C+ +GH + +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKYCIF 263
Query: 429 C--SRLKESFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSV 485
S ++V+GS+D V +W L K ++ K LQ H + S
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----------LQG------HTDVVIST 307
Query: 486 AIAPNDKLLATGS--QDRTAKLW 506
A P + ++A+ + D+T KLW
Sbjct: 308 ACHPTENIIASAALENDKTIKLW 330
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/179 (20%), Positives = 71/179 (39%), Gaps = 4/179 (2%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V I +V +G L++L + ++A + D ++V++S L W G +
Sbjct: 153 VRIWDVKTGKCLKTLPAHS-DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT-R 165
PV+ + F P + D +++WD + + G + + + T
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSG--RDKICIIW 222
+ S + D + +W+LQ + + L H V S A + + S+ DK +W
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 102 bits (255), Expect = 1e-21
Identities = 72/302 (23%), Positives = 132/302 (43%), Gaps = 19/302 (6%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
HT V+++ F P LA+ D +++W G + VA+ D L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN--L 101
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
L S++ D +++W + CL L H + V F+ + ++S D+ IWD+++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
+ +T+P +PVS + G +++ G R+W+ ASGQC+ T
Sbjct: 162 KCLKTLPAH----------SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 288 PPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEE--VLDVRFLGP 345
P ++ + +L AT D+ L L++ + K + G+ E + F
Sbjct: 212 DDNP--PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 346 EDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASCA--KDQSVRI 402
+V S + ++ LQT Q L GHTD+V++ + AS A D+++++
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
Query: 403 WR 404
W+
Sbjct: 330 WK 331
Score = 97.8 bits (242), Expect = 3e-20
Identities = 49/155 (31%), Positives = 81/155 (52%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H K ++SV +PN + LA+ S D+ K+W + SGH+ G+ V +S +L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+AS D T+K+W + CLKT +GH V F + ++S D V++W +K +C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 598 VRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
++TL AH D V +H +R ++ + D +W
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 97.1 bits (240), Expect = 6e-20
Identities = 67/274 (24%), Positives = 129/274 (47%), Gaps = 20/274 (7%)
Query: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGG 128
+++ SP+ E L ++S L+ W +G + H ++ +A+ S LL +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNLLVSAS 106
Query: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCL 188
D +++WD+ +G V F+P L+ S + D ++R+W ++ CL
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTGKCL 164
Query: 189 AVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEE 248
L AH V+++ F+ DG ++SS D +C IWD S Q +T+ +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL---------IDDDNP 215
Query: 249 PVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAH---TAG 305
PVS + G Y L A TL++W+ + G+C+ T G E +C A+ T G
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---GHKNE-KYCIFANFSVTGG 271
Query: 306 VVLTATADHNLL-LYEARSLRLQKQFAGYSEEVL 338
+ + ++ NL+ ++ ++ + ++ G+++ V+
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/216 (26%), Positives = 99/216 (45%), Gaps = 17/216 (7%)
Query: 418 SGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC 477
+GHT +V +V S E +L + S D +K+W K +
Sbjct: 42 AGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISG--------------- 85
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H I+ VA + + LL + S D+T K+W + + L GH ++C F+P ++
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+ S D ++++W ++ CLKT H V V F G+ ++SS DGL ++W + +C
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 598 VRTL-DAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
++TL D V + S + L D+ + LW
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 87.8 bits (216), Expect = 4e-17
Identities = 80/323 (24%), Positives = 141/323 (43%), Gaps = 43/323 (13%)
Query: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV-------FELQTSACQILHGHTDI 378
L+ AG+++ V V+F P + +S +K+ FE S ++ G +D+
Sbjct: 37 LKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL--GISDV 93
Query: 379 VLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKES-FL 437
+ D L S + D++++IW ++ C+ GH++ V CC+ +S +
Sbjct: 94 AWSSD----SNLLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYV--FCCNFNPQSNLI 144
Query: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATG 497
V+GS D +V++W + K T H +++V + L+ +
Sbjct: 145 VSGSFDESVRIWDVKTGKCLK---------------TLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 498 SQDRTAKLW--ALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSC 555
S D ++W A QC L + + V+FSP + + A+ D T+KLW C
Sbjct: 190 SYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 556 LKTFEGHDAS---VLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
LKT+ GH + V+ G ++S D LV +W ++ E V+ L H D V
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Query: 613 CSRLDDHALTGA--SDSRVILWK 633
C ++ + A +D + LWK
Sbjct: 309 CHPTENIIASAALENDKTIKLWK 331
Score = 76.3 bits (186), Expect = 1e-13
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 4/144 (2%)
Query: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
P AT S+ K P L +GH + + V+FSP + LA++SAD IK+W
Sbjct: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Query: 549 ALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKV 608
D KT GH + VA+ S L+S+ D +K+W + + +C++TL H + V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 609 WGLHCSRLDDHALTGASDSRVILW 632
+ + + + ++G+ D V +W
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIW 156
Score = 73.2 bits (178), Expect = 9e-13
Identities = 68/323 (21%), Positives = 139/323 (43%), Gaps = 40/323 (12%)
Query: 191 LTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPV 250
L H AV+S+ FS +G + SS DK+ IW + +T+ + +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL----------GI 90
Query: 251 SQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTA 310
S + S ++A D TL++W+ +SG+C+ T G + C + ++++
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNFNPQSNLIVSG 147
Query: 311 TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC- 369
+ D ++ +++ ++ + K +S+ V V F + S +V +S ++++ + C
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 370 -QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVC 428
++ V + G + D ++++W +K C+ +GH + +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKYCIF 263
Query: 429 C--SRLKESFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSV 485
S ++V+GS+D V +W L K ++ K LQ H + S
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----------LQG------HTDVVIST 307
Query: 486 AIAPNDKLLATGS--QDRTAKLW 506
A P + ++A+ + D+T KLW
Sbjct: 308 ACHPTENIIASAALENDKTIKLW 330
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/179 (20%), Positives = 71/179 (39%), Gaps = 4/179 (2%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
V I +V +G L++L + ++A + D ++V++S L W G +
Sbjct: 153 VRIWDVKTGKCLKTLPAHS-DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT-R 165
PV+ + F P + D +++WD + + G + + + T
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSG--RDKICIIW 222
+ S + D + +W+LQ + + L H V S A + + S+ DK +W
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 101 bits (252), Expect = 2e-21
Identities = 73/265 (27%), Positives = 123/265 (46%), Gaps = 22/265 (8%)
Query: 350 VVVASNSPCLKVFELQTSACQI---LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
VV S +KV++ + + L GH V+++D+ + AS + D +R+W +
Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
Query: 407 KAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP 466
Q+ + G ++ S+ +L TG+ V ++ +
Sbjct: 95 NGKQIKSIDAGPVDAWTLAFSPDSQ----YLATGTHVGKVNIFGVESG------------ 138
Query: 467 ILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWC 526
+ + + K I S+A +P+ K LA+G+ D ++ + +LL GH +
Sbjct: 139 ---KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
Query: 527 VQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
+ FSP Q+L TAS DG IK++ +Q + T GH + VL VAF T +SS SD
Sbjct: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
Query: 587 VKLWTIKNNECVRTLDAHEDKVWGL 611
VK+W + CV T H+D+VWG+
Sbjct: 256 VKVWDVGTRTCVHTFFDHQDQVWGV 280
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 9/189 (4%)
Query: 35 TGQHLFCVCGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWA 94
TG H+ +VNI V SG SL+ + I + SPD + L + + ++ +
Sbjct: 123 TGTHV-----GKVNIFGVESGKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIFD 176
Query: 95 WQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVV 154
G + + H P+ ++ F P S LL T DG ++++D+ G V
Sbjct: 177 IATGKLLHTLEG-HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
Query: 155 HLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSG 214
VAF PD T + SS++D +++VW + R+C+ H V + ++ +G ++S G
Sbjct: 236 LNVAFCPDDTHFV--SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG 293
Query: 215 RDKICIIWD 223
D+ I+D
Sbjct: 294 DDQEIHIYD 302
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/291 (22%), Positives = 124/291 (42%), Gaps = 29/291 (9%)
Query: 121 STLLATGGCDGAVRVW-------DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173
S + TG D V+VW D+ H GVV + H P + SS+
Sbjct: 32 SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL----GVVSVDISHTLP---IAASSSL 84
Query: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTV 233
DA IR+W L++ + + A +LAFS D + + I+ ++S +
Sbjct: 85 DAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK---- 140
Query: 234 PVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQ 293
E ++ + + + G Y + G + +++ A+G+ ++T G
Sbjct: 141 ------EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL---EGHAM 191
Query: 294 ELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA 353
+ T + + +++TA+ D + +Y+ + L +G++ VL+V F P+D+H V +
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-PDDTHFVSS 250
Query: 354 SNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
S+ +KV+++ T C H D V + G S DQ + I+
Sbjct: 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 63.9 bits (154), Expect = 6e-10
Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 35/245 (14%)
Query: 397 DQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKE-SFLVTGSQDCTVKLWPLPKAL 455
D V++W+ + Q S H +G V + S D ++LW L
Sbjct: 41 DDLVKVWKWRDERLDL---QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGK 97
Query: 456 LSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLG 515
K+ D GP+ D ++A +P+ + LATG+ + + + G
Sbjct: 98 QIKSI--DAGPV-------------DAWTLAFSPDSQYLATGTH--------VGKVNIFG 134
Query: 516 VFSGHR------RG--LWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
V SG + RG + + +SP + LA+ + DG I ++ + L T EGH +
Sbjct: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
Query: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDS 627
+ F L+++ DG +K++ +++ TL H V + D H ++ +SD
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
Query: 628 RVILW 632
V +W
Sbjct: 255 SVKVW 259
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/205 (25%), Positives = 82/205 (40%), Gaps = 14/205 (6%)
Query: 437 LVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLAT 496
+VTGS D VK+W L Q + H + SV I+ + A+
Sbjct: 35 VVTGSLDDLVKVWKWRDE-------------RLDLQWSLEGHQLGVVSVDISHTLPIAAS 81
Query: 497 GSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556
S D +LW L + + W + FSP Q LAT + G + ++ ++
Sbjct: 82 SSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE 141
Query: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL 616
+ + +L +A+ G L S DG++ ++ I + + TL+ H + L S
Sbjct: 142 YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP- 200
Query: 617 DDHALTGASDSRVILWKDVTEAEQA 641
D L ASD I DV A A
Sbjct: 201 DSQLLVTASDDGYIKIYDVQHANLA 225
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 12/182 (6%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRA----LLLAQWAWQEGSVTR 102
+ + ++ +G ++S++ D SPD++ L T + + + +E S+
Sbjct: 88 IRLWDLENGKQIKSIDA-GPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
Query: 103 LWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPD 162
K I ++A+ P LA+G DG + ++DI H G + + F PD
Sbjct: 147 RGKFI-----LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201
Query: 163 PTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIW 222
LL +++ D I+++ +Q + L+ H S V ++AF D +SS DK +W
Sbjct: 202 SQ--LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
Query: 223 DL 224
D+
Sbjct: 260 DV 261
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 8/169 (4%)
Query: 475 QRCHDKDINSVAIAPNDK----LLATGSQDRTAKLWAL--PQCQLLGVFSGHRRGLWCVQ 528
++ HD I SVA N K + TGS D K+W + L GH+ G+ V
Sbjct: 12 EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71
Query: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSD-GLV 587
S + A++S D I+LW L++ +K+ + +AF S +Q L++G+ G V
Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAF-SPDSQYLATGTHVGKV 130
Query: 588 KLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVT 636
++ +++ + +LD + + S + +GA D + ++ T
Sbjct: 131 NIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT 179
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 97.8 bits (242), Expect = 3e-20
Identities = 112/459 (24%), Positives = 184/459 (40%), Gaps = 92/459 (20%)
Query: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP 246
C + L H AV S+AFS G + S D WDL + E+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST----------ETPHFTCKGH 155
Query: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGV 306
V + G + G + +W+ ++G+ V G+ L
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQV---------GRTL----------- 195
Query: 307 VLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQT 366
A H+ K G S E L PE +V +S +++++
Sbjct: 196 -----AGHS------------KWITGLSWEPLHAN---PECRYVASSSKDGSVRIWDTTA 235
Query: 367 SACQ-ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVG 425
C+ IL GHT V L G L+ S ++D+++++WR + V+C GH H V
Sbjct: 236 GRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDG--VLCRTL-QGHGHWVN 291
Query: 426 TVCCSRLKESFLVTGS----------QDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQ 475
T+ S + L TG+ QD L L + LS+ L++ Q +
Sbjct: 292 TMALST--DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN-------LVRGQGPE 342
Query: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQL-LGVFSGHRRGLWCVQFSPMDQ 534
R L +GS D T LW+ + + L +GH+ + V FSP +
Sbjct: 343 R-----------------LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR 385
Query: 535 VLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
++A+AS D +IKLW + L + GH A+V ++A+ + L+S SD +K+W +K
Sbjct: 386 IVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA 445
Query: 595 NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
+ L H D+V+ + S +G D + +W+
Sbjct: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 76.6 bits (187), Expect = 8e-14
Identities = 93/390 (23%), Positives = 155/390 (39%), Gaps = 91/390 (23%)
Query: 99 SVTRLWKAI--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHF--RGSPGVV 154
+VTR ++ H+ V ++AF PT LA+G D VR WD+ T HF +G V
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE--TPHFTCKGHRHWV 159
Query: 155 HLVAFHPDPTRLL----------------------------------------------L 168
+++ PD +L +
Sbjct: 160 LSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYV 219
Query: 169 FSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQ 228
SS+ D ++R+W C +LT H +VT L + DG + S+ +D+ +W
Sbjct: 220 ASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGV 278
Query: 229 ATRTVP--------------------VFESVEAAV----------LLPEEPVSQLG-VKS 257
RT+ FE EA+V L E +S+ V+
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
Query: 258 PGLYFLTAG-DQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNL 316
G L +G D TL +W A + T+ G + + + +V +A+ D ++
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTRM--TGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 317 LLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA-SNSPCLKVFELQTSACQI-LHG 374
L++ R+ + G+ V + + DS ++V+ S+ LKV++++ + L G
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAW--SADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
Query: 375 HTDIVLALDVFRKGWLFASCAKDQSVRIWR 404
H D V A+D G AS KD+ +RIWR
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 61.2 bits (147), Expect = 4e-09
Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 4/165 (2%)
Query: 60 SLEQEDQEDITAFDL--SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAF 117
SL++ + ++ ++L E LV+ S L W+ E H A + + F
Sbjct: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF 380
Query: 118 DPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAI 177
P S ++A+ D ++++WD RG V+ +A+ D LL S ++D+ +
Sbjct: 381 SPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTL 438
Query: 178 RVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIW 222
+VW ++ + L H V ++ +S DG + S G+DK IW
Sbjct: 439 KVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 56.6 bits (135), Expect = 9e-08
Identities = 50/203 (24%), Positives = 88/203 (43%), Gaps = 26/203 (12%)
Query: 366 TSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN-KAGQVMCVAQGSGHTHSV 424
T L GH++ V+++ G AS + D +VR W ++ + C GH H V
Sbjct: 104 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWV 159
Query: 425 GTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINS 484
++ S L +G ++ + LW P G Q T H K I
Sbjct: 160 LSISWSPDGRK-LASGCKNGQILLWD-----------PSTGK---QVGRTLAGHSKWITG 204
Query: 485 VA-----IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
++ P + +A+ S+D + ++W + + +GH + + C+++ D +L +A
Sbjct: 205 LSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG-DGLLYSA 263
Query: 540 SADGTIKLWALQDFSCLKTFEGH 562
S D TIK+W D +T +GH
Sbjct: 264 SQDRTIKVWRAHDGVLCRTLQGH 286
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/82 (26%), Positives = 33/82 (40%)
Query: 555 CLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCS 614
C + EGH +V+ VAF G L S D V+ W + T H V + S
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 615 RLDDHALTGASDSRVILWKDVT 636
+G + +++LW T
Sbjct: 166 PDGRKLASGCKNGQILLWDPST 187
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 96.3 bits (238), Expect = 1e-19
Identities = 59/248 (23%), Positives = 109/248 (43%), Gaps = 29/248 (11%)
Query: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTV--CCSRLKESFLVTGSQDCTVKLWP 450
+ +D +RIW +N+ Q +A HT V + CC+ L++ S D TVK+W
Sbjct: 47 TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG---KTLISASSDTTVKVWN 103
Query: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQ 510
K +T R H + ++A A + +L+A+ DR LW +
Sbjct: 104 AHKGF---------------CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
Query: 511 CQLLGV---------FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEG 561
L SG++ ++ + + + ++ + S + +++W + + L +G
Sbjct: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
Query: 562 HDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHAL 621
H +V + GTQ LS SDG ++LW++ C+ T H++ VW L + H
Sbjct: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268
Query: 622 TGASDSRV 629
+G D ++
Sbjct: 269 SGGRDRKI 276
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/278 (21%), Positives = 117/278 (42%), Gaps = 17/278 (6%)
Query: 333 YSEEVLDVRFLGPEDSHVVVASNSPCLKVFEL----QTSACQILHGHTDIVLALDVFRKG 388
Y+ ++ L P + + A ++++ + Q + HTD V + + G
Sbjct: 28 YNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG 87
Query: 389 WLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKL 448
S + D +V++W +K C++ H V + ++ KE + + D + L
Sbjct: 88 KTLISASSDTTVKVWNAHKG---FCMSTLRTHKDYVKALAYAKDKE-LVASAGLDRQIFL 143
Query: 449 WPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD-INSVAIAPNDKLLATGSQDRTAKLWA 507
W + L+ TA +N T+ +KD I S+A+ ++ +GS ++ ++W
Sbjct: 144 WDVNT--LTALTASNN-----TVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
Query: 508 LPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
C L GH + + + + S+DGTI+LW+L C+ T+ HD V
Sbjct: 197 PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256
Query: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHE 605
+ T + S G D + ++N + +R L E
Sbjct: 257 ALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLICEE 293
Score = 61.2 bits (147), Expect = 4e-09
Identities = 37/164 (22%), Positives = 73/164 (44%), Gaps = 9/164 (5%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H +N + + N K L + S D T K+W + + H+ + + ++ +++A
Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
Query: 538 TASADGTIKLWALQDFSCL---------KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVK 588
+A D I LW + + L + G+ S+ +A GT ++S ++ +++
Sbjct: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193
Query: 589 LWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
+W + + L H D V L +R L+G+SD + LW
Sbjct: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/172 (22%), Positives = 75/172 (43%), Gaps = 16/172 (9%)
Query: 112 VATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL---- 167
V + DP L T G D +R+W + +H + P + + H D +
Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQH------KQDPYIASM-EHHTDWVNDIVLCC 85
Query: 168 ----LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
L S+++D ++VW+ C++ L H V +LA++ D + S+G D+ +WD
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 224 LQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
+ + A T +++ ++ + L + G ++ + LRVW+
Sbjct: 146 VNTLTAL-TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
Score = 53.9 bits (128), Expect = 6e-07
Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 3/116 (2%)
Query: 520 HRRGLWCVQFSPMDQVLATASADGTIKLWALQDFS---CLKTFEGHDASVLKVAFVSRGT 576
+R G+ +Q P L TA D I++W++ + + E H V + G
Sbjct: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
Query: 577 QLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
L+S+ SD VK+W C+ TL H+D V L ++ + + D ++ LW
Sbjct: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLW 144
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/238 (22%), Positives = 94/238 (39%), Gaps = 29/238 (12%)
Query: 61 LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAI--HTAPVATMAFD 118
+E+ ++ + A L P L TA R ++ W+ + ++ HT V +
Sbjct: 25 VEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC 84
Query: 119 PTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIR 178
L + D V+VW+ + + R V +A+ D + L+ S+ D I
Sbjct: 85 CNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD--KELVASAGLDRQIF 142
Query: 179 VWSLQDRSCLAVLTAHYSAVT------------SLAFSADGHTMLSSGRDKICIIWDLQS 226
+W D + L LTA + VT SLA + G ++S +K+ +WD ++
Sbjct: 143 LW---DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 199
Query: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284
C + A+LL + G L+ GT+R+W +C+ T
Sbjct: 200 CAKLMKLKGHTDNVKALLLNRD----------GTQCLSGSSDGTIRLWSLGQQRCIAT 247
Score = 50.8 bits (120), Expect = 5e-06
Identities = 49/228 (21%), Positives = 92/228 (40%), Gaps = 24/228 (10%)
Query: 18 ERKIEPFYKGGKAQLDQTGQHLFCVCG---------TRVNILEVASGAVLRSLEQEDQED 68
+ K +P+ + D + C G T V + G + +L ++
Sbjct: 61 QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTH-KDY 119
Query: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATM----------AFD 118
+ A + D E++ AS L + W ++T L + +T +++ A +
Sbjct: 120 VKALAYAKDKELV--ASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMN 177
Query: 119 PTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIR 178
T++ +G + +RVWD +G V + + D T+ L S ++D IR
Sbjct: 178 QLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCL--SGSSDGTIR 235
Query: 179 VWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
+WSL + C+A H V +L + + S GRD+ DL++
Sbjct: 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRN 283
Score = 50.1 bits (118), Expect = 8e-06
Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 25/250 (10%)
Query: 3 ETAAGVGRFKTNYAVERKIEPFYKGG--KAQLDQTGQHLFCVCGTRVNILEVAS------ 54
+ AG + + +Y + ++E + + G QLD LF R +I+ + S
Sbjct: 7 QNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTA--GRDSIIRIWSVNQHKQ 64
Query: 55 GAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVAT 114
+ S+E + + L + + L++AS + W +G + H V
Sbjct: 65 DPYIASMEHHT-DWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRT-HKDYVKA 122
Query: 115 MAFDPTSTLLATGGCDGAVRVWDIV---------RHYGTHHFRGSPGVVHLVAFHPDPTR 165
+A+ L+A+ G D + +WD+ T G+ ++ +A + T
Sbjct: 123 LAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT- 181
Query: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL- 224
++ S +T+ +RVW + + L L H V +L + DG LS D +W L
Sbjct: 182 -IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240
Query: 225 -QSCQATRTV 233
Q C AT V
Sbjct: 241 QQRCIATYRV 250
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 95.5 bits (236), Expect = 2e-19
Identities = 53/155 (34%), Positives = 79/155 (50%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H ++NS A +P+ ++L TGS+D W QLL GH + +FSP + A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
+AS D T++LW + CL+ +GH SV V+F QL S G D V LW +++ +
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 598 VRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
+R L H D + S + TG+ DS V +W
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Score = 90.1 bits (222), Expect = 7e-18
Identities = 77/297 (25%), Positives = 124/297 (41%), Gaps = 19/297 (6%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
H V + AF P +L TG DG V W+ G G V F PD
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH--- 76
Query: 168 LFSSAT-DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
LF+SA+ D +R+W + CL VL H +V +++FS D + S G DK ++WD+QS
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
Query: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGD-QGTLRVWEAASGQCVYTQ 285
Q R +L+ Q SP + L G T+ +W+ +
Sbjct: 137 GQMLR-----------LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 286 AQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGP 345
G ++ C +G++ + + D + +++ + L Q G+ V + F P
Sbjct: 186 QALEGHSANIS-CLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF-SP 243
Query: 346 EDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVR 401
++ + A S +KV++ T C + L G D+ G + S A DQ+ R
Sbjct: 244 DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 83.6 bits (205), Expect = 7e-16
Identities = 83/285 (29%), Positives = 118/285 (41%), Gaps = 29/285 (10%)
Query: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILH---GHTDIV 379
++R K F + EV F P+ ++ S C V+ +T + Q+L GHT V
Sbjct: 10 AVRRVKFFGQHGGEVNSSAF-SPDGQMLLTGSEDGC--VYGWETRSGQLLWRLGGHTGPV 66
Query: 380 LALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVT 439
G LFAS + D +VR+W + +A C+ GH SV TV S L +
Sbjct: 67 KFCRFSPDGHLFASASCDCTVRLWDVARA---KCLRVLKGHQRSVETVSFSPDSRQ-LAS 122
Query: 440 GSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQ 499
G D V LW + + + LL H I S +P LATGS
Sbjct: 123 GGWDKRVMLWDVQSGQMLR---------LLVG------HRDSIQSSDFSPTVNCLATGSW 167
Query: 500 DRTAKLWALPQCQLL---GVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556
D T +W L GH + C+ +S +LA+ S D TI +W S L
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLL 226
Query: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTL 601
+GH V +AF L S+G +VK+W +C+ TL
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
Score = 74.3 bits (181), Expect = 4e-13
Identities = 74/295 (25%), Positives = 130/295 (44%), Gaps = 21/295 (7%)
Query: 292 GQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVV 351
G E+ + ++LT + D + +E RS +L + G++ V RF D H+
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF--SPDGHLF 78
Query: 352 VASNSPC-LKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAG 409
+++ C ++++++ + C ++L GH V + AS D+ V +W + ++G
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSG 137
Query: 410 QVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILL 469
Q++ + G H S+ + S L TGS D TV +W L + + G
Sbjct: 138 QMLRLLVG--HRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEG---- 190
Query: 470 QAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQF 529
H +I+ + + + LLA+GS D+T +W LL GH + + F
Sbjct: 191 --------HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241
Query: 530 SPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSD 584
SP + LA+A +K+W CL+T +G AF G L+S +D
Sbjct: 242 SPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/201 (27%), Positives = 84/201 (41%), Gaps = 10/201 (4%)
Query: 38 HLFCV--CGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAW 95
HLF C V + +VA LR L+ Q + SPD+ L + + W
Sbjct: 76 HLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 96 QEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDI--VRHYGTHH-FRGSPG 152
Q G + RL H + + F PT LATG D V +WD+ V +H G
Sbjct: 135 QSGQMLRLLVG-HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Query: 153 VVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLS 212
+ + + LL S + D I +W S L L H + V S+AFS D + S
Sbjct: 194 NISCLCYSASG---LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 213 SGRDKICIIWDLQSCQATRTV 233
+G ++ +WD + + T+
Sbjct: 251 AGYSRMVKVWDCNTGKCLETL 271
Score = 66.6 bits (161), Expect = 9e-11
Identities = 51/205 (24%), Positives = 81/205 (39%), Gaps = 19/205 (9%)
Query: 437 LVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLAT 496
L+TGS+D V W L GP+ +P+ L A+
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKF---------------CRFSPDGHLFAS 80
Query: 497 GSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556
S D T +LW + + + L V GH+R + V FSP + LA+ D + LW +Q L
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECV---RTLDAHEDKVWGLHC 613
+ GH S+ F L + D V +W ++ + L+ H + L C
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL-C 199
Query: 614 SRLDDHALTGASDSRVILWKDVTEA 638
+G+ D + +WK T +
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSS 224
Score = 53.5 bits (127), Expect = 8e-07
Identities = 57/274 (20%), Positives = 112/274 (40%), Gaps = 34/274 (12%)
Query: 259 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
G LT + G + WE SGQ ++ GP + C + + +A+ D + L
Sbjct: 33 GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP---VKFCRFSPDGHLFASASCDCTVRL 89
Query: 319 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTD 377
++ + + G+ V V F P+ + + ++++Q+ ++L GH D
Sbjct: 90 WDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148
Query: 378 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 437
+ + D A+ + D +V IW + + GH+ ++ +C S L
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA--SGLL 206
Query: 438 VTGSQDCTVKLW-PLPKALL-----------SKNTAPD---------NGPILLQAQTTQR 476
+GS D T+ +W P +LL S +PD + + + T +
Sbjct: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Query: 477 CHDK-----DI-NSVAIAPNDKLLATGSQDRTAK 504
C + D+ ++ A P+ K+L +G+ D+T +
Sbjct: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 95.1 bits (235), Expect = 2e-19
Identities = 63/208 (30%), Positives = 102/208 (49%), Gaps = 19/208 (9%)
Query: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVK 447
G L ASC D+ +RIW + GH +V V S ++L + S D T
Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG-NYLASASFDATTC 86
Query: 448 LWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWA 507
+W K D + TT H+ ++ SVA AP+ LLAT S+D++ +W
Sbjct: 87 IW--------KKNQDD-----FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Query: 508 L---PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ--DFSCLKTFEGH 562
+ + + + V + H + + V + P ++LA+AS D T+KL+ + D+ C T EGH
Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGH 193
Query: 563 DASVLKVAFVSRGTQLLSSGSDGLVKLW 590
+++V +AF G +L S D V++W
Sbjct: 194 ESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 66.2 bits (160), Expect = 1e-10
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 7/163 (4%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQ--CQLLGVFSGHRRGLWCVQFSPMDQV 535
H + + VA +P LA+ S D T +W Q + + GH + V ++P +
Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNL 119
Query: 536 LATASADGTIKLWALQD---FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
LAT S D ++ +W + + + C+ H V V + L S+ D VKL+
Sbjct: 120 LATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE 179
Query: 593 KNNE--CVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
+ ++ C TL+ HE VW L + + D V +W+
Sbjct: 180 EEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR 222
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 10/129 (7%)
Query: 489 PNDKLLATGSQDRTAKLWALPQ----CQLLGVFSGHRRGLWCVQFSPMDQVLATASADGT 544
P LLA+ DR ++W C+ + + GH+R + V +SP LA+AS D T
Sbjct: 26 PAGTLLASCGGDRRIRIWGTEGDSWICKSV-LSEGHQRTVRKVAWSPCGNYLASASFDAT 84
Query: 545 IKLWALQ--DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN---ECVR 599
+W DF C+ T EGH+ V VA+ G L + D V +W + ECV
Sbjct: 85 TCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVS 144
Query: 600 TLDAHEDKV 608
L++H V
Sbjct: 145 VLNSHTQDV 153
Score = 61.2 bits (147), Expect = 4e-09
Identities = 64/251 (25%), Positives = 106/251 (42%), Gaps = 40/251 (15%)
Query: 372 LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
L GH + V ++ G L A+C++D+SV +W +++ + CV+ + HT V V
Sbjct: 101 LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP 160
Query: 432 LKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND 491
+E L + S D TVKL+ + D T H+ + S+A P+
Sbjct: 161 SQE-LLASASYDDTVKLY--------REEEDD-----WVCCATLEGHESTVWSLAFDPSG 206
Query: 492 KLLATGSQDRTAKLW---------------ALPQCQLLGVFSG-HRRGLWCVQFSPMDQV 535
+ LA+ S DRT ++W + P + + SG H R ++ + + +
Sbjct: 207 QRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266
Query: 536 LATASADGTIKLWALQDFS---------CLKTFEGHDASVLKVAFVSRGTQLLSSGS-DG 585
LATA D I+++ S + H V VA+ + LL+S S DG
Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDG 326
Query: 586 LVKLWTIKNNE 596
V W + E
Sbjct: 327 EVAFWKYQRPE 337
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 6/123 (4%)
Query: 525 WCVQFSPMDQVLATASADGTIKLWALQDFS--CLKTF-EGHDASVLKVAFVSRGTQLLSS 581
W + ++P +LA+ D I++W + S C EGH +V KVA+ G L S+
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 582 GSDGLVKLWTIKNN--ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639
D +W + ECV TL+ HE++V + + + T + D V +W +V E +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW-EVDEED 138
Query: 640 QAE 642
+ E
Sbjct: 139 EYE 141
Score = 52.8 bits (125), Expect = 1e-06
Identities = 72/327 (22%), Positives = 124/327 (37%), Gaps = 38/327 (11%)
Query: 201 LAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGL 260
LA++ G + S G D+ IW + + E + V ++ G
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEG-------HQRTVRKVAWSPCGN 74
Query: 261 YFLTAGDQGTLRVWEAASG--QCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
Y +A T +W+ +CV T G E+ A + ++ T + D ++ +
Sbjct: 75 YLASASFDATTCIWKKNQDDFECVTTLE---GHENEVKSVAWAPSGNLLATCSRDKSVWV 131
Query: 319 YEARSLRLQKQFAGYSEEVLDVRFL--GPEDSHVVVASNSPCLKVFELQTS---ACQILH 373
+E + + + DV+ + P + AS +K++ + C L
Sbjct: 132 WEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLE 191
Query: 374 GHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVM------------CVAQGSG-H 420
GH V +L G ASC+ D++VRIWR G C+ SG H
Sbjct: 192 GHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFH 251
Query: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
+ ++ + +L + L T D ++++ N+ P L A Q H +
Sbjct: 252 SRTIYDIAWCQLTGA-LATACGDDAIRVFQ-----EDPNSDPQQPTFSLTAHLHQ-AHSQ 304
Query: 481 DINSVAIAPNDK-LLATGSQDRTAKLW 506
D+N VA P + LLA+ S D W
Sbjct: 305 DVNCVAWNPKEPGLLASCSDDGEVAFW 331
Score = 47.8 bits (112), Expect = 4e-05
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 19/135 (14%)
Query: 115 MAFDPTSTLLATGGCDGAVRVWDIVRHYGTHH---------FRGSPGVVHLVAFHPDPTR 165
+A++P TLLA+ G D +R+W GT G V VA+ P
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIW------GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY 75
Query: 166 LLLFSSATDAAIRVW--SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
L S++ DA +W + D C+ L H + V S+A++ G+ + + RDK +W+
Sbjct: 76 LA--SASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Query: 224 LQSCQATRTVPVFES 238
+ V V S
Sbjct: 134 VDEEDEYECVSVLNS 148
Score = 47.8 bits (112), Expect = 4e-05
Identities = 39/125 (31%), Positives = 61/125 (48%), Gaps = 17/125 (13%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI--------VRHYGTHHFRGSPGVVHLVAF 159
H V ++A+ P+ LLAT D +V VW++ V +H + V H+V +
Sbjct: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH----TQDVKHVV-W 158
Query: 160 HPDPTRLLLFSSATDAAIRVWSLQ--DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDK 217
HP ++ LL S++ D ++++ + D C A L H S V SLAF G + S D+
Sbjct: 159 HP--SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216
Query: 218 ICIIW 222
IW
Sbjct: 217 TVRIW 221
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 94.4 bits (233), Expect = 4e-19
Identities = 60/222 (27%), Positives = 106/222 (47%), Gaps = 30/222 (13%)
Query: 445 TVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC----HDKDINSVAIAPNDKLLATGSQD 500
+V +P+P+ + +T P +G + + T C HD ++N+V +P +LLATG D
Sbjct: 287 SVSSFPVPQD--NVDTHPGSGKEV-RVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMD 343
Query: 501 RTAKLWAL--PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
R KLW + +C+ G SG G+ ++F L AS D ++W + D+ T
Sbjct: 344 RRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHT 403
Query: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL-- 616
GH VL F+ +++S D +KLW +++ C++T+ A G C+ +
Sbjct: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFA------GSSCNDIVC 457
Query: 617 -DDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQEL 657
+ ++G D ++ W D+ + E +VR+ EL
Sbjct: 458 TEQCVMSGHFDKKIRFW-DI-----------RSESIVREMEL 487
Score = 63.5 bits (153), Expect = 7e-10
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTH-HFRGSPGVVH--LVAFHPDPT 164
H V + F P S LLATGG D V++W++ +G F+GS + + + D
Sbjct: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEV---FGEKCEFKGSLSGSNAGITSIEFDSA 377
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L +++ D A R+W++ D LT H V S F D ++S D+ +WDL
Sbjct: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
Query: 225 QSCQATRTV 233
+S +TV
Sbjct: 438 RSKVCIKTV 446
Score = 44.3 bits (103), Expect = 5e-04
Identities = 64/302 (21%), Positives = 120/302 (39%), Gaps = 36/302 (11%)
Query: 257 SPGLYFL-TAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
SPG L T G +++WE +C + + G +T +L A+ D
Sbjct: 331 SPGSRLLATGGMDRRVKLWEVFGEKCEF-KGSLSGSNAGITSIEFDSAGSYLLAASNDFA 389
Query: 316 LLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC--QILH 373
++ RL+ G+S +VL +FL +++ +V S+ LK+++L++ C +
Sbjct: 390 SRIWTVDDYRLRHTLTGHSGKVLSAKFL-LDNARIVSGSHDRTLKLWDLRSKVCIKTVFA 448
Query: 374 GHT--DIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
G + DIV G D+ +R W + V +G +
Sbjct: 449 GSSCNDIVCTEQCVMSGHF------DKKIRFWDIRSESIVR-------EMELLGKITALD 495
Query: 432 L--KESFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIA 488
L + + L++ S+D +K+ L A+ +AP +C D V +
Sbjct: 496 LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG-----------FKC-GSDWTRVVFS 543
Query: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRGLWCVQFSPMDQVLATASADGTIKL 547
P+ +A GS + + +W++ ++ V S H + V +SP + + L
Sbjct: 544 PDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVL 603
Query: 548 WA 549
WA
Sbjct: 604 WA 605
Score = 40.0 bits (92), Expect = 0.009
Identities = 68/292 (23%), Positives = 115/292 (39%), Gaps = 36/292 (12%)
Query: 330 FAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQI---LHGHTDIVLALDVFR 386
F + EV V+F P + +K++E+ C+ L G + +++
Sbjct: 318 FDAHDGEVNAVQF-SPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 376
Query: 387 KGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTV 446
G + + D + RIW ++ + SG S + L + +V+GS D T+
Sbjct: 377 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFL----LDNARIVSGSHDRTL 432
Query: 447 KLWPLPKALLSKNTAPDNG--PILLQAQTTQRCH-DK-----DINSVAIAPNDKLLA--- 495
KLW L + K + I+ Q H DK DI S +I +LL
Sbjct: 433 KLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKIT 492
Query: 496 ------------TGSQDRTAKLWALPQCQLLGVFS--GHRRGL-WC-VQFSPMDQVLATA 539
+ S+D K+ L + FS G + G W V FSP +A
Sbjct: 493 ALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAG 552
Query: 540 SADGTIKLWALQDFSCLKTF-EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
SA+G++ +W++ K + H +S+ VA+ G+ ++S LW
Sbjct: 553 SAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
Score = 35.8 bits (81), Expect = 0.16
Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
++ ++ S +++R +E + ITA DL+P+ L++ SR LL + ++ + +
Sbjct: 470 KIRFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS 527
Query: 106 AIHT---APVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAF--H 160
A + + F P + +A G +G++ +W ++ G V V H
Sbjct: 528 APGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVL-----------TGKVEKVLSKQH 576
Query: 161 PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHY 195
+ +S + + V D+ C AVL A Y
Sbjct: 577 SSSINAVAWSPSGSHVVSV----DKGCKAVLWAQY 607
Score = 34.3 bits (77), Expect = 0.47
Identities = 65/308 (21%), Positives = 117/308 (37%), Gaps = 60/308 (19%)
Query: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL--QSCQATRTVPVFESVEAAV 243
+ L V AH V ++ FS + + G D+ +W++ + C+ + ++
Sbjct: 313 TALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE----------FKGSL 362
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
++ + S G Y L A + R+W + +T G+ L+ L
Sbjct: 363 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLT--GHSGKVLSAKFLLDN 420
Query: 304 AGVVLTATADHNLLLYEARS-LRLQKQFAGYS-------EEVL-------DVRF------ 342
A +V + + D L L++ RS + ++ FAG S E+ + +RF
Sbjct: 421 ARIV-SGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSE 479
Query: 343 ----------------LGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFR 386
L PE + ++ S LKV +L+T+A + D R
Sbjct: 480 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTR 539
Query: 387 -----KGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGS 441
G A+ + + S+ IW + G+V V H+ S+ V S S +V+
Sbjct: 540 VVFSPDGSYVAAGSAEGSLYIWSV-LTGKVEKVL-SKQHSSSINAVAWSP-SGSHVVSVD 596
Query: 442 QDCTVKLW 449
+ C LW
Sbjct: 597 KGCKAVLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 94.4 bits (233), Expect = 4e-19
Identities = 60/222 (27%), Positives = 106/222 (47%), Gaps = 30/222 (13%)
Query: 445 TVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC----HDKDINSVAIAPNDKLLATGSQD 500
+V +P+P+ + +T P +G + + T C HD ++N+V +P +LLATG D
Sbjct: 268 SVSSFPVPQD--NVDTHPGSGKEV-RVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMD 324
Query: 501 RTAKLWAL--PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
R KLW + +C+ G SG G+ ++F L AS D ++W + D+ T
Sbjct: 325 RRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHT 384
Query: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL-- 616
GH VL F+ +++S D +KLW +++ C++T+ A G C+ +
Sbjct: 385 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFA------GSSCNDIVC 438
Query: 617 -DDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQEL 657
+ ++G D ++ W D+ + E +VR+ EL
Sbjct: 439 TEQCVMSGHFDKKIRFW-DI-----------RSESIVREMEL 468
Score = 63.5 bits (153), Expect = 7e-10
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTH-HFRGSPGVVH--LVAFHPDPT 164
H V + F P S LLATGG D V++W++ +G F+GS + + + D
Sbjct: 302 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEV---FGEKCEFKGSLSGSNAGITSIEFDSA 358
Query: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
L +++ D A R+W++ D LT H V S F D ++S D+ +WDL
Sbjct: 359 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418
Query: 225 QSCQATRTV 233
+S +TV
Sbjct: 419 RSKVCIKTV 427
Score = 44.3 bits (103), Expect = 5e-04
Identities = 64/302 (21%), Positives = 120/302 (39%), Gaps = 36/302 (11%)
Query: 257 SPGLYFL-TAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
SPG L T G +++WE +C + + G +T +L A+ D
Sbjct: 312 SPGSRLLATGGMDRRVKLWEVFGEKCEF-KGSLSGSNAGITSIEFDSAGSYLLAASNDFA 370
Query: 316 LLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC--QILH 373
++ RL+ G+S +VL +FL +++ +V S+ LK+++L++ C +
Sbjct: 371 SRIWTVDDYRLRHTLTGHSGKVLSAKFL-LDNARIVSGSHDRTLKLWDLRSKVCIKTVFA 429
Query: 374 GHT--DIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
G + DIV G D+ +R W + V +G +
Sbjct: 430 GSSCNDIVCTEQCVMSGHF------DKKIRFWDIRSESIVR-------EMELLGKITALD 476
Query: 432 L--KESFLVTGSQDCTVKLWPL-PKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIA 488
L + + L++ S+D +K+ L A+ +AP +C D V +
Sbjct: 477 LNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG-----------FKC-GSDWTRVVFS 524
Query: 489 PNDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRGLWCVQFSPMDQVLATASADGTIKL 547
P+ +A GS + + +W++ ++ V S H + V +SP + + L
Sbjct: 525 PDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVL 584
Query: 548 WA 549
WA
Sbjct: 585 WA 586
Score = 40.0 bits (92), Expect = 0.009
Identities = 68/292 (23%), Positives = 115/292 (39%), Gaps = 36/292 (12%)
Query: 330 FAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQI---LHGHTDIVLALDVFR 386
F + EV V+F P + +K++E+ C+ L G + +++
Sbjct: 299 FDAHDGEVNAVQF-SPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 357
Query: 387 KGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTV 446
G + + D + RIW ++ + SG S + L + +V+GS D T+
Sbjct: 358 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFL----LDNARIVSGSHDRTL 413
Query: 447 KLWPLPKALLSKNTAPDNG--PILLQAQTTQRCH-DK-----DINSVAIAPNDKLLA--- 495
KLW L + K + I+ Q H DK DI S +I +LL
Sbjct: 414 KLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKIT 473
Query: 496 ------------TGSQDRTAKLWALPQCQLLGVFS--GHRRGL-WC-VQFSPMDQVLATA 539
+ S+D K+ L + FS G + G W V FSP +A
Sbjct: 474 ALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAG 533
Query: 540 SADGTIKLWALQDFSCLKTF-EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
SA+G++ +W++ K + H +S+ VA+ G+ ++S LW
Sbjct: 534 SAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585
Score = 35.8 bits (81), Expect = 0.16
Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
++ ++ S +++R +E + ITA DL+P+ L++ SR LL + ++ + +
Sbjct: 451 KIRFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFS 508
Query: 106 AIHT---APVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAF--H 160
A + + F P + +A G +G++ +W ++ G V V H
Sbjct: 509 APGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVL-----------TGKVEKVLSKQH 557
Query: 161 PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHY 195
+ +S + + V D+ C AVL A Y
Sbjct: 558 SSSINAVAWSPSGSHVVSV----DKGCKAVLWAQY 588
Score = 34.3 bits (77), Expect = 0.47
Identities = 65/308 (21%), Positives = 117/308 (37%), Gaps = 60/308 (19%)
Query: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL--QSCQATRTVPVFESVEAAV 243
+ L V AH V ++ FS + + G D+ +W++ + C+ + ++
Sbjct: 294 TALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE----------FKGSL 343
Query: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
++ + S G Y L A + R+W + +T G+ L+ L
Sbjct: 344 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLT--GHSGKVLSAKFLLDN 401
Query: 304 AGVVLTATADHNLLLYEARS-LRLQKQFAGYS-------EEVL-------DVRF------ 342
A +V + + D L L++ RS + ++ FAG S E+ + +RF
Sbjct: 402 ARIV-SGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSE 460
Query: 343 ----------------LGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFR 386
L PE + ++ S LKV +L+T+A + D R
Sbjct: 461 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTR 520
Query: 387 -----KGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGS 441
G A+ + + S+ IW + G+V V H+ S+ V S S +V+
Sbjct: 521 VVFSPDGSYVAAGSAEGSLYIWSV-LTGKVEKVL-SKQHSSSINAVAWSP-SGSHVVSVD 577
Query: 442 QDCTVKLW 449
+ C LW
Sbjct: 578 KGCKAVLW 585
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 94.0 bits (232), Expect = 5e-19
Identities = 63/221 (28%), Positives = 102/221 (46%), Gaps = 19/221 (8%)
Query: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVK 447
G L A+ D V +W +NK C+ +GHT V +V + E +V GSQ +++
Sbjct: 33 GRLLATGGDDCRVNLWSINKPN---CIMSLTGHTSPVESVRLNT-PEELIVAGSQSGSIR 88
Query: 448 LWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWA 507
+W L A + + T H +I S+ P + +A+GSQD KLW
Sbjct: 89 VWDLEAAKILR---------------TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWD 133
Query: 508 LPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
+ + + + GH + + C++FSP + LA+A+ D T+KLW L + F GH V
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN 193
Query: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKV 608
V F L S SD ++ W ++ + V ++ V
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPV 234
Score = 88.6 bits (218), Expect = 2e-17
Identities = 53/213 (24%), Positives = 91/213 (42%), Gaps = 15/213 (7%)
Query: 420 HTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD 479
H +V ++ + L TG DC V LW + N P + + T H
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSI------------NKPNCIMSLTG---HT 63
Query: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
+ SV + ++L+ GSQ + ++W L ++L GH+ + + F P + +A+
Sbjct: 64 SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
Query: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
S D IKLW ++ C+ + GH +V + F G L S+ D VKLW + + +
Sbjct: 124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
Query: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
H V + + +G+SD + W
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 68.2 bits (165), Expect = 3e-11
Identities = 44/182 (24%), Positives = 84/182 (46%), Gaps = 5/182 (2%)
Query: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
+ + ++ + +LR+L + +I + D P E + + S+ + W + ++
Sbjct: 87 IRVWDLEAAKILRTL-MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG 145
Query: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166
H+ V + F P LA+ D V++WD+ F G G V++V FHP+
Sbjct: 146 -HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN--EY 202
Query: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICII-WDLQ 225
LL S ++D IR W L+ ++ + V S+ F+ DG + S +D + + W+ +
Sbjct: 203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
Query: 226 SC 227
C
Sbjct: 263 RC 264
Score = 66.6 bits (161), Expect = 9e-11
Identities = 48/185 (25%), Positives = 76/185 (41%), Gaps = 14/185 (7%)
Query: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
HT+PV ++ + L+ G G++RVWD+ G + + FHP
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE--F 119
Query: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+ S + D I++W ++ + C+ H AV L FS DG + S+ D +WDL +
Sbjct: 120 VASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG 179
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQG-TLRVWEAASGQCVYTQA 286
+ P PV+ + P Y L +G T+R W+ Q V
Sbjct: 180 KMMSEFPGHTG----------PVNVVEF-HPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228
Query: 287 QPPGP 291
PGP
Sbjct: 229 GEPGP 233
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVR 134
SPD + L +A+ + W G + + HT PV + F P LLA+G D +R
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 135 VWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAH 194
WD+ + G PG V V F+PD L+S D ++RV+ + C V+ +
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPD--GCCLYSGCQD-SLRVYGWEPERCFDVVLVN 271
Query: 195 YSAVTSLAFSAD 206
+ V LA D
Sbjct: 272 WGKVADLAICND 283
Score = 55.1 bits (131), Expect = 3e-07
Identities = 51/260 (19%), Positives = 101/260 (38%), Gaps = 59/260 (22%)
Query: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
LL + D + +WS+ +C+ LT H S V S+ + +++ + +WDL++
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGT-LRVWEAASGQCVYTQ 285
+ RT+ ++ + L P + F+ +G Q T +++W+ CV+
Sbjct: 95 AKILRTLMGHKANICS--LDFHPYGE---------FVASGSQDTNIKLWDIRRKGCVF-- 141
Query: 286 AQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGP 345
++ G+S+ V +RF P
Sbjct: 142 -------------------------------------------RYRGHSQAVRCLRF-SP 157
Query: 346 EDSHVVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWR 404
+ + A++ +K+++L GHT V ++ +L AS + D+++R W
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Query: 405 MNKAGQVMCVAQGSGHTHSV 424
+ K V C+ G SV
Sbjct: 218 LEKFQVVSCIEGEPGPVRSV 237
Score = 52.8 bits (125), Expect = 1e-06
Identities = 48/185 (25%), Positives = 78/185 (42%), Gaps = 13/185 (7%)
Query: 108 HTAPVATMAFDPTS-TLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166
H + V+++ S LLATGG D V +W I + G V V + P L
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN-TPEEL 77
Query: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
++ S + +IRVW L+ L L H + + SL F G + S +D +WD++
Sbjct: 78 IVAGSQS-GSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR- 135
Query: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQA 286
R VF + + V L G + +A D T+++W+ +G+ +
Sbjct: 136 ----RKGCVFRYRGHS-----QAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
Query: 287 QPPGP 291
GP
Sbjct: 187 GHTGP 191
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 93.2 bits (230), Expect = 9e-19
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 429 CSRLKES--FLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486
C+R +LVTGS D +++W + K+ + QAQ D + +
Sbjct: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKD-------LKYQAQDNFMMMDDAVLCMC 271
Query: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRGLWCVQFSPMDQVLATASADGTI 545
+ + ++LATG+QD K+W + Q L F H +G+ C+ FS + +AS D TI
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 546 KLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRT 600
++ L+ LK F GH + V + F G ++S+ SDG VK+W +K EC T
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/308 (22%), Positives = 128/308 (41%), Gaps = 37/308 (12%)
Query: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWK-------AIHTAPVATMAFDPTSTLLATG 127
SPD + LVT S + W + G + + K + V M F + +LATG
Sbjct: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
Query: 128 GCDGAVRVWDI-----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL 182
DG ++VW I +R + H +G V ++F D +++L S++ D IR+ L
Sbjct: 283 AQDGKIKVWKIQSGQCLRRFERAHSKG----VTCLSFSKDSSQIL--SASFDQTIRIHGL 336
Query: 183 QDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFES---- 238
+ L H S V F+ DGH ++S+ D IW++++ + + T S
Sbjct: 337 KSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGT 396
Query: 239 ---VEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQEL 295
V + +LLP+ P +F+ T+ + GQ V + + G +
Sbjct: 397 DITVNSVILLPKNPE----------HFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGGDF 445
Query: 296 THCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASN 355
C L+ + D L + + +L++ + ++V+ + P + + S
Sbjct: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAH-HPHQNLIATYSE 504
Query: 356 SPCLKVFE 363
LK+++
Sbjct: 505 DGLLKLWK 512
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/177 (25%), Positives = 73/177 (41%), Gaps = 21/177 (11%)
Query: 117 FDPTSTLLATGGCDGAVRVWDI--------VRHYGTHHFRGSPGVVHLVAFHPDPTRLLL 168
F P L TG DG + VW+ +++ +F V + F D +L
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE--ML 279
Query: 169 FSSATDAAIRVWSLQDRSCLAVL-TAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
+ A D I+VW +Q CL AH VT L+FS D +LS+ D+ I L+S
Sbjct: 280 ATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSG 339
Query: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284
+ + S V++ G Y ++A GT+++W + +C T
Sbjct: 340 KTLKEFRGHSSF----------VNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
Score = 61.2 bits (147), Expect = 4e-09
Identities = 39/160 (24%), Positives = 74/160 (46%), Gaps = 9/160 (5%)
Query: 482 INSVAIAPNDKLLATGSQDRTAKLWALP--------QCQLLGVFSGHRRGLWCVQFSPMD 533
+ +P+ + L TGS D ++W + Q F + C+ FS
Sbjct: 217 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 276
Query: 534 QVLATASADGTIKLWALQDFSCLKTFE-GHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
++LAT + DG IK+W +Q CL+ FE H V ++F +Q+LS+ D +++ +
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL 336
Query: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
K+ + ++ H V ++ + ++ +SD V +W
Sbjct: 337 KSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 55.5 bits (132), Expect = 2e-07
Identities = 37/121 (30%), Positives = 61/121 (50%), Gaps = 11/121 (9%)
Query: 519 GHRRGLWCVQFSPMDQVLATASADGTIKLWALQ--------DFSCLKTFEGHDASVLKVA 570
G + + C +FSP Q L T S DG I++W + F D +VL +
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
Query: 571 FVSRGTQLLSSGS-DGLVKLWTIKNNECVRTLD-AHEDKVWGLHCSRLDDHALTGASDSR 628
F SR T++L++G+ DG +K+W I++ +C+R + AH V L S+ L+ + D
Sbjct: 272 F-SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 629 V 629
+
Sbjct: 331 I 331
Score = 55.1 bits (131), Expect = 3e-07
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 15/134 (11%)
Query: 427 VCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486
+C SR E L TG+QD +K+W + +G L + +R H K + ++
Sbjct: 270 MCFSRDTE-MLATGAQDGKIKVWKI-----------QSGQCL---RRFERAHSKGVTCLS 314
Query: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIK 546
+ + + + S D+T ++ L + L F GH + F+ + +AS+DGT+K
Sbjct: 315 FSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 374
Query: 547 LWALQDFSCLKTFE 560
+W ++ C TF+
Sbjct: 375 IWNMKTTECSNTFK 388
Score = 47.8 bits (112), Expect = 4e-05
Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 20/238 (8%)
Query: 359 LKVFELQTSAC--QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQ 416
+KV+++Q+ C + H+ V L + S + DQ++RI + K+G+ + +
Sbjct: 288 IKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL-KSGKTL--KE 344
Query: 417 GSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQR 476
GH+ V ++ ++++ S D TVK+W + K NT G A T
Sbjct: 345 FRGHSSFVNEATFTQ-DGHYIISASSDGTVKIWNM-KTTECSNTFKSLGST---AGT--- 396
Query: 477 CHDKDINSVAIAP-NDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRG--LWCVQFSPM 532
D +NSV + P N + ++ T + + Q Q++ FS G R G C SP
Sbjct: 397 --DITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIVRSFSSGKREGGDFVCCALSPR 453
Query: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
+ + D + ++ +T H+ V+ +A + + DGL+KLW
Sbjct: 454 GEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/366 (17%), Positives = 124/366 (33%), Gaps = 82/366 (22%)
Query: 196 SAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGV 255
S V FS DG +++ D +W+ + + + + + ++ ++ V +
Sbjct: 215 SHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY--QAQDNFMMMDDAVLCMCF 272
Query: 256 KSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
T G ++VW+ SGQC+ + G +T + + + +L+A+ D
Sbjct: 273 SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG--VTCLSFSKDSSQILSASFDQT 330
Query: 316 LLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGH 375
+ ++ +S + K+F GH
Sbjct: 331 IRIHGLKSGKTLKEF------------------------------------------RGH 348
Query: 376 TDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKES 435
+ V + G S + D +V+IW M T CS +S
Sbjct: 349 SSFVNEATFTQDGHYIISASSDGTVKIWNMK-------------------TTECSNTFKS 389
Query: 436 FLVTGSQDCTVKLWPLPKALLSKNTAP------DNGPILLQAQ-------TTQRCHDKDI 482
T D TV LL KN N +++ Q ++ + D
Sbjct: 390 LGSTAGTDITVN----SVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDF 445
Query: 483 NSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASAD 542
A++P + + +D ++ +L + H + + + P ++AT S D
Sbjct: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSED 505
Query: 543 GTIKLW 548
G +KLW
Sbjct: 506 GLLKLW 511
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 92.8 bits (229), Expect = 1e-18
Identities = 51/157 (32%), Positives = 78/157 (49%)
Query: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQV 535
R H+ ++ V++ P+ +L + +DR K+ LP+C +L GH L F P
Sbjct: 349 RLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDK 408
Query: 536 LATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN 595
LAT+S D T+KLW L C+ TFEGH +V + S G + SS D K+W + +
Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
Query: 596 ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
C TL H D V + + LT ++D + +W
Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
Score = 79.3 bits (194), Expect = 1e-14
Identities = 63/234 (26%), Positives = 99/234 (42%), Gaps = 32/234 (13%)
Query: 360 KVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSG 419
++ EL S C + H DI++ SC +D R+W++ + + G G
Sbjct: 349 RLHELPVS-CVSMQPHKDILV------------SCGED---RLWKVLGLPKCNVLLTGFG 392
Query: 420 HTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD 479
HT + CC L T S D TVKLW L K G +L T H
Sbjct: 393 HTDWLSD-CCFHPSGDKLATSSGDTTVKLWDLCK-----------GDCIL----TFEGHS 436
Query: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
+ + S +A+ S D+T+K+W + + GH + ++F P L T+
Sbjct: 437 RAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTS 496
Query: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIK 593
SAD T+ +W + C ++ GH S+ F RG + S + G+ KLW +
Sbjct: 497 SADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
Score = 72.0 bits (175), Expect = 2e-12
Identities = 38/127 (29%), Positives = 58/127 (45%)
Query: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
H ++ P+ LAT S D T KLW L + + F GH R +W + +A
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
Query: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
++S D T K+W + C T GH SV + F LL+S +D + +W + C
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 598 VRTLDAH 604
++L H
Sbjct: 513 EQSLYGH 519
Score = 62.0 bits (149), Expect = 2e-09
Identities = 67/266 (25%), Positives = 106/266 (39%), Gaps = 32/266 (12%)
Query: 332 GYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWL 390
G+++ + D F P + +S +K+++L C + GH+ V + G
Sbjct: 392 GHTDWLSDCCF-HPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNF 450
Query: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP 450
AS + D++ +IW +N C GHT SV ++ + L+T S D T+ +W
Sbjct: 451 VASSSLDKTSKIWDVNSE---RCRCTLYGHTDSVNSIEFFPFSNT-LLTSSADKTLSIWD 506
Query: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW---- 506
+ ++ H IN P ++A+ KLW
Sbjct: 507 ARTGICEQSLYG---------------HMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Query: 507 ALPQCQL-LGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDAS 565
LP + +G G+ V F +VLA AS +G I L L+ K GH+
Sbjct: 552 LLPIVSIDIGPSPGNE-----VNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM-GHENE 605
Query: 566 VLKVAFVSRGTQLLSSGSDGLVKLWT 591
V F G L S GSDG V+ W+
Sbjct: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 15/138 (10%)
Query: 102 RLWKAI-------------HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFR 148
RLWK + HT ++ F P+ LAT D V++WD+ + F
Sbjct: 374 RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFE 433
Query: 149 GSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGH 208
G V +H + SS+ D ++W + C L H +V S+ F +
Sbjct: 434 GHSRAVWSCTWHSCGN--FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 491
Query: 209 TMLSSGRDKICIIWDLQS 226
T+L+S DK IWD ++
Sbjct: 492 TLLTSSADKTLSIWDART 509
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/185 (23%), Positives = 70/185 (37%), Gaps = 15/185 (8%)
Query: 458 KNTAPDNGPI---LLQAQTTQRCHDKDINS-------VAIAPNDKLLATGSQDRTAKLWA 507
K AP+ GP L +A+ +C K + + + PN L + AK
Sbjct: 284 KENAPE-GPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKF-- 340
Query: 508 LPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567
+L +F H + CV P +L + D K+ L + L T GH +
Sbjct: 341 --DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLS 398
Query: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDS 627
F G +L +S D VKLW + +C+ T + H VW + + + D
Sbjct: 399 DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDK 458
Query: 628 RVILW 632
+W
Sbjct: 459 TSKIW 463
Score = 48.5 bits (114), Expect = 2e-05
Identities = 38/205 (18%), Positives = 78/205 (38%), Gaps = 13/205 (6%)
Query: 76 PDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRV 135
P + L T+S + W +G ++ H+ V + + +A+ D ++
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCKGDCILTFEG-HSRAVWSCTWHSCGNFVASSSLDKTSKI 462
Query: 136 WDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHY 195
WD+ G V+ + F P LL +S+ D + +W + C L H
Sbjct: 463 WDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL--TSSADKTLSIWDARTGICEQSLYGHM 520
Query: 196 SAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGV 255
++ F GH + S + +WD + + +P+ ++ + P +++
Sbjct: 521 HSINDAIFDPRGHMIASCDACGVTKLWDFR-----KLLPI-----VSIDIGPSPGNEVNF 570
Query: 256 KSPGLYFLTAGDQGTLRVWEAASGQ 280
S G A G + + + SG+
Sbjct: 571 DSSGRVLAQASGNGVIHLLDLKSGE 595
Score = 37.4 bits (85), Expect = 0.056
Identities = 51/270 (18%), Positives = 97/270 (35%), Gaps = 62/270 (22%)
Query: 73 DLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGA 132
D+ P N L + +L A++ ++ ++ RL H PV+ ++ P +L + G D
Sbjct: 321 DMQP-NPNLNVSKESLSPAKFDYKLKNIFRL----HELPVSCVSMQPHKDILVSCGEDRL 375
Query: 133 VRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLT 192
+V + + G + FHP +L +S+ D +++W L C+
Sbjct: 376 WKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA--TSSGDTTVKLWDLCKGDCILTFE 433
Query: 193 AHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQ 252
H AV S + + G+ + SS DK
Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDK----------------------------------- 458
Query: 253 LGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATA 312
T ++W+ S +C T G + + +LT++A
Sbjct: 459 -----------------TSKIWDVNSERCRCTLY---GHTDSVNSIEFFPFSNTLLTSSA 498
Query: 313 DHNLLLYEARSLRLQKQFAGYSEEVLDVRF 342
D L +++AR+ ++ G+ + D F
Sbjct: 499 DKTLSIWDARTGICEQSLYGHMHSINDAIF 528
Score = 36.6 bits (83), Expect = 0.096
Identities = 33/157 (21%), Positives = 66/157 (42%), Gaps = 6/157 (3%)
Query: 67 EDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTR-LWKAIHTAPVATMAFDPTSTLLA 125
+ + + + P + L+T+S L+ W + G + L+ +H+ + FDP ++A
Sbjct: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHS--INDAIFDPRGHMIA 536
Query: 126 TGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDR 185
+ G ++WD + P + V F D + +L ++ + I + L+
Sbjct: 537 SCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF--DSSGRVLAQASGNGVIHLLDLKSG 594
Query: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIW 222
+ L H + ++ FS DG + S G D W
Sbjct: 595 E-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 35.4 bits (80), Expect = 0.21
Identities = 24/92 (26%), Positives = 38/92 (41%), Gaps = 13/92 (14%)
Query: 100 VTRLWKAIHTAPVATMA----------FDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRG 149
VT+LW P+ ++ FD + +LA +G + + D+ + H G
Sbjct: 543 VTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL-KSGEIHKLMG 601
Query: 150 SPGVVHLVAFHPDPTRLLLFSSATDAAIRVWS 181
H V F D +LFS +D +R WS
Sbjct: 602 HENEAHTVVFSHDGE--ILFSGGSDGTVRTWS 631
>gi|13376751 proteasomal ATPase-associated factor 1 [Homo sapiens]
Length = 392
Score = 91.7 bits (226), Expect = 3e-18
Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 17/200 (8%)
Query: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPM 532
T R H K I + I+ L + S D T K+W +L V GH + C +F P
Sbjct: 86 TFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPS 145
Query: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
V+ + D +K+W+ +D SC+ TF+GH +L A V RG ++S+ DG +LW
Sbjct: 146 GLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Query: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652
+ C+ L C + GA+D+ + L + EQ E +V
Sbjct: 206 GRSACLGVL---------ADCGSSINGVAVGAADNSINL--------GSPEQMPSEREVG 248
Query: 653 RQQELDNLLHEKRYLRALGL 672
+ ++ L E + L+ LGL
Sbjct: 249 TEAKMLLLAREDKKLQCLGL 268
Score = 61.6 bits (148), Expect = 3e-09
Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 21/311 (6%)
Query: 107 IHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL 166
IHT + + L + DG +++W G V+ F P + L
Sbjct: 90 IHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFP--SGL 147
Query: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD--- 223
++ S DA +++WS +D SC+ H + A G ++S+ RD +WD
Sbjct: 148 VVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 207
Query: 224 ------LQSCQATRTVPVFESVEAAVLL--PEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
L C ++ + + ++ L PE+ S+ V + L A + L+
Sbjct: 208 SACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLG 267
Query: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335
S Q V+ G + +C + ++L T D N+ + RS R Q S
Sbjct: 268 LQSRQLVFLFI-----GSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSG 322
Query: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCA 395
+ + L D + + C V + ++ D V + + K +C
Sbjct: 323 APV-LSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEK--QIYTCC 379
Query: 396 KDQSVRIWRMN 406
+D VR ++++
Sbjct: 380 RDGLVRRYQLS 390
Score = 33.5 bits (75), Expect = 0.81
Identities = 46/208 (22%), Positives = 82/208 (39%), Gaps = 25/208 (12%)
Query: 351 VVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAG 409
V +S +K+++ + +L GH V F G + S D ++IW A
Sbjct: 108 VSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIW---SAE 164
Query: 410 QVMCVAQGSGHTHSV-GTVCCSRLKESFLVTGSQDCTVKLWPLPKA----LLSKNTAPDN 464
CV GH + T R + +V+ S+D T +LW ++ +L+ + N
Sbjct: 165 DASCVVTFKGHKGGILDTAIVDRGRN--VVSASRDGTARLWDCGRSACLGVLADCGSSIN 222
Query: 465 GPILLQAQTT-------QRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVF 517
G + A + Q ++++ + A K+L +D+ + L QL+ +F
Sbjct: 223 GVAVGAADNSINLGSPEQMPSEREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLF 277
Query: 518 SGHRRGLWCVQFSPMDQVLATASADGTI 545
G C S +L + DG I
Sbjct: 278 IGSDAFNCCTFLSGF--LLLAGTQDGNI 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,540,201
Number of Sequences: 37866
Number of extensions: 1394606
Number of successful extensions: 9296
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 4171
Number of HSP's gapped (non-prelim): 2602
length of query: 808
length of database: 18,247,518
effective HSP length: 110
effective length of query: 698
effective length of database: 14,082,258
effective search space: 9829416084
effective search space used: 9829416084
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.