Guide to the Human Genome
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Search of human proteins with 194018553

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018553 solute carrier family 9 isoform 3 regulator 2
isoform a [Homo sapiens]
         (337 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo...   690   0.0  
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor...   657   0.0  
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s...   327   9e-90
gi|21361142 PDZ domain containing 1 [Homo sapiens]                    141   9e-34
gi|21630285 PDZ domain containing 3 [Homo sapiens]                    131   1e-30
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo...    87   2e-17
gi|45827729 scribble isoform b [Homo sapiens]                          79   6e-15
gi|45827731 scribble isoform a [Homo sapiens]                          79   6e-15
gi|112382257 InaD-like [Homo sapiens]                                  76   5e-14
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    72   9e-13
gi|31742501 sorting nexin family member 27 [Homo sapiens]              71   2e-12
gi|148746189 multiple PDZ domain protein [Homo sapiens]                70   2e-12
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    70   3e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi...    69   8e-12
gi|41281808 harmonin isoform b3 [Homo sapiens]                         67   2e-11
gi|71480164 harmonin isoform a [Homo sapiens]                          67   2e-11
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    67   2e-11
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    67   2e-11
gi|8922944 lin-7 homolog C [Homo sapiens]                              64   2e-10
gi|11545920 lin-7 homolog B [Homo sapiens]                             64   2e-10
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    63   3e-10
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    63   3e-10
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    63   3e-10
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    63   3e-10
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    63   3e-10
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]    63   4e-10
gi|87196343 PDZ domain containing 2 [Homo sapiens]                     61   1e-09
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           61   2e-09
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           61   2e-09
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    61   2e-09

>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
           a [Homo sapiens]
          Length = 337

 Score =  690 bits (1781), Expect = 0.0
 Identities = 337/337 (100%), Positives = 337/337 (100%)

Query: 1   MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
           MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN
Sbjct: 1   MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60

Query: 61  GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
           GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE
Sbjct: 61  GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120

Query: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
           PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD
Sbjct: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180

Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
           PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240

Query: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300
           VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL
Sbjct: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300

Query: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337
           HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Sbjct: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337


>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
           [Homo sapiens]
          Length = 326

 Score =  657 bits (1694), Expect = 0.0
 Identities = 326/337 (96%), Positives = 326/337 (96%), Gaps = 11/337 (3%)

Query: 1   MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
           MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN
Sbjct: 1   MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60

Query: 61  GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
           GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE
Sbjct: 61  GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120

Query: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
           PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD
Sbjct: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180

Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
           PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240

Query: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300
           VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTE           ESGL
Sbjct: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTE-----------ESGL 289

Query: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337
           HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Sbjct: 290 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 326


>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
           sapiens]
          Length = 358

 Score =  327 bits (838), Expect = 9e-90
 Identities = 187/359 (52%), Positives = 225/359 (62%), Gaps = 31/359 (8%)

Query: 2   AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNG 61
           AA  PL PRLC L +G  GYGFHLHGEKG+ GQ+IR VEPGSPAE A L AGDRLVEVNG
Sbjct: 6   AAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNG 64

Query: 62  VNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPPAHDPW 119
            NVE ETH QVV RI+A     RLLVVD ETDE+L++  +   EE+  AQ     A  P 
Sbjct: 65  ENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPA 124

Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSV 179
             +   A   +   EA K       RELRPRLC ++KGP GYGFNLHSDKS+PGQ+IRSV
Sbjct: 125 AAEVQGAGNENEPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSV 182

Query: 180 DPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
           DP SPA  SGLRAQDR++EVNG  +EG +H +VV++I+A  DE +LLVVD ETDE FK+ 
Sbjct: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242

Query: 240 RVTPTEEHVEGPLPSPVTNG------------------TSPAQLNGGSACSSR----SDL 277
           RV P++EH+ GPLP P TNG                    PA +   S+ +S      D 
Sbjct: 243 RVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302

Query: 278 PGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSN 336
           P     T   S    DP  +  + L    A AKE+A   R +KRAPQMDW++K E+FSN
Sbjct: 303 PPKQDSTAPSSTSSSDPILDFNISL----AMAKERAHQKRSSKRAPQMDWSKKNELFSN 357


>gi|21361142 PDZ domain containing 1 [Homo sapiens]
          Length = 519

 Score =  141 bits (355), Expect = 9e-34
 Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 13/287 (4%)

Query: 6   PLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
           P +PR+  + +G  GYGF+L     ++GQ I+ ++ GSPAE A L+  D +V VNG +VE
Sbjct: 238 PHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297

Query: 66  GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
              H  VV+ I+    QT LLVVD+ETD   R    +       + LP       P P  
Sbjct: 298 TLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP 357

Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPA 185
                 S     ++V     + +P+LC L KG  GYGF+L++ +  PG +I+ V  G PA
Sbjct: 358 TSLEVSSPPDTTEEV-----DHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPA 412

Query: 186 ARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTE 245
             +GL  +D +IEVNG NV    + +VV  I++      LLV   +  ++F+  ++ P  
Sbjct: 413 DLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIV 471

Query: 246 EHVEGPLPSP-------VTNGTSPAQLNGGSACSSRSDLPGSDKDTE 285
             +  PL +P       V      + +    A S+ S    + +DTE
Sbjct: 472 SSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTE 518



 Score =  139 bits (349), Expect = 5e-33
 Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 32/247 (12%)

Query: 8   RPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
           +PRLC LV+    YGF L   +G++G ++  + P   A  A + A D L+EVNG NVE  
Sbjct: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDA 191

Query: 68  THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
           +H +VV+++K    +   L+VD+ETD+    +++    E A   L P             
Sbjct: 192 SHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH------------ 239

Query: 128 TGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAAR 187
                               +PR+  ++KG  GYGF L +   + GQ I+ +D GSPA  
Sbjct: 240 --------------------QPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEE 279

Query: 188 SGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
           +GL+  D ++ VNG++VE L H  VV  I+   D+  LLVVD ETD  ++    +P   +
Sbjct: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYY 339

Query: 248 VEGPLPS 254
               LP+
Sbjct: 340 QSQELPN 346



 Score =  128 bits (322), Expect = 6e-30
 Identities = 83/234 (35%), Positives = 116/234 (49%), Gaps = 30/234 (12%)

Query: 9   PRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
           PR C+L + E Q YGF L  EK   G  +R VE  SPAE A L+ GDR++ +NGV V+ E
Sbjct: 7   PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66

Query: 68  THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
            H QVV  ++       LLV+D ++ E+  + ++                      D   
Sbjct: 67  EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRV----------------------DLKE 104

Query: 128 TGSHSSEAGKKD-VSGPLRE------LRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
            G    E G  D +  P+         +PRLC+L K    YGF+L + + + G Y+  + 
Sbjct: 105 LGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDIT 164

Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDE 234
           P   A R+G+ A D LIEVNG+NVE   H EVV  +K        L+VD ETD+
Sbjct: 165 PQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 40/119 (33%), Positives = 62/119 (52%), Gaps = 8/119 (6%)

Query: 149 PRLCHLRKGP-QGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
           PR C L K   Q YGF L  +K   G  +R V+  SPA ++GL+  DR++ +NG  V+  
Sbjct: 7   PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66

Query: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRV-------TPTEEHVEGPLPSPVTNG 259
            H +VV  ++   +   LLV+D ++ E   + RV       +  E+ +   + SPV NG
Sbjct: 67  EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNG 125


>gi|21630285 PDZ domain containing 3 [Homo sapiens]
          Length = 491

 Score =  131 bits (329), Expect = 1e-30
 Identities = 97/264 (36%), Positives = 130/264 (49%), Gaps = 56/264 (21%)

Query: 7   LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
           +RPRLC +V+ E G+GF +    G +G F   +  G  AE A +  G RL+EVNG+   G
Sbjct: 153 VRPRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
           +              Q  LLV   E +E+ R           Q GLP A    E    WA
Sbjct: 211 Q--------------QVTLLVAGPEVEEQCR-----------QLGLPLAAPLAE---GWA 242

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKS---RPGQYIRSVDPGS 183
                                +PR  HL KGPQG+GF L  +K    RPGQ++  VDPG 
Sbjct: 243 ------------------LPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGL 284

Query: 184 PAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
           PA ++G++A DRL+ V G++VEGL H E V+ I+ +     L VVDPE D  F  +R++P
Sbjct: 285 PAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344

Query: 244 T--EEHVEGPLPSPVTNGTSPAQL 265
               E+ E P  SP   G+S A L
Sbjct: 345 LLFLENTEAP-ASP--QGSSSASL 365



 Score =  119 bits (298), Expect = 4e-27
 Identities = 82/219 (37%), Positives = 108/219 (49%), Gaps = 9/219 (4%)

Query: 6   PLRPRLCRLVRGEQGYGFHLHGEKG---RRGQFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
           P +PR   L +G QG+GF L  EKG   R GQF+  V+PG PA+ A ++AGDRLV V G 
Sbjct: 244 PTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGE 303

Query: 63  NVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPK 122
           +VEG  H + V RI+       L VVD E D      +L+         L     P  P+
Sbjct: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLS-----PLLFLENTEAPASPQ 358

Query: 123 PDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQG-YGFNLHSDKSRPGQYIRSVDP 181
              + +   + +   +D S P   L  R C L  GP G YGF L    S P  +I  V P
Sbjct: 359 GSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTP 418

Query: 182 GSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKARE 220
           G  AAR+GL+  D ++EVNG  V G    E +  +   E
Sbjct: 419 GGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457



 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 76/253 (30%), Positives = 110/253 (43%), Gaps = 59/253 (23%)

Query: 8   RPRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
           RPR C L + E + +GFHL  E GR G  + RV+PG+ A+   L+ GDR++ VN   VE 
Sbjct: 46  RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
           E +  VV+RI+A   +  L V+ +   +  R          AQ G               
Sbjct: 106 EDYAVVVRRIRASSPRVLLTVLARHAHDVAR----------AQLG--------------- 140

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAA 186
                  +A      GP   +RPRLCH+ K   G+GF++      P   + S   G  A 
Sbjct: 141 ------EDAHLCPTLGP--GVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLST--GGAAE 190

Query: 187 RSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEE 246
           R+G+    RL+EVNG    G               +  LLV  PE +E  ++L +     
Sbjct: 191 RAGVPPGARLLEVNGLWQSG--------------QQVTLLVAGPEVEEQCRQLGL----- 231

Query: 247 HVEGPLPSPVTNG 259
               PL +P+  G
Sbjct: 232 ----PLAAPLAEG 240


>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
           sapiens]
          Length = 227

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 47/136 (34%), Positives = 73/136 (53%), Gaps = 4/136 (2%)

Query: 5   EPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNV 64
           E  +P+LCRL +GE GYGFHL+  +G  G FI+ V+ G PA+ A L   D ++EVNGVNV
Sbjct: 51  EDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNV 110

Query: 65  EGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD 124
             E + +VV RI++      LLV  ++  +  + +++     +A     P   P + K  
Sbjct: 111 LDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLAD----PLDTPPDSKEG 166

Query: 125 WAHTGSHSSEAGKKDV 140
                +H S   K+ +
Sbjct: 167 IVVESNHDSHMAKERI 182



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 39/108 (36%), Positives = 62/108 (57%), Gaps = 1/108 (0%)

Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
           +P+LC L KG  GYGF+L++ +  PG +I+ V  G PA  +GL  +D +IEVNG NV   
Sbjct: 54  KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 113

Query: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSP 255
            + +VV  I++      LLV   +  ++F+  ++ P    +  PL +P
Sbjct: 114 PYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIVSSLADPLDTP 160


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 81/259 (31%), Positives = 105/259 (40%), Gaps = 56/259 (21%)

Query: 3    APEPLRPR-LCRLVRGEQGYGFHLHGEKGRR-------GQFIRRVEPGSPAE-AAALRAG 53
            +P PLR R +  L R E+G GF + G KG         G F+ R+  G  A  A  L+ G
Sbjct: 853  SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912

Query: 54   DRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP 113
            DR++ +NGV+V    H   V  + A      LL+                 E  A   LP
Sbjct: 913  DRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-----------------EREAGGPLP 955

Query: 114  PAHDPWEPKPDWAHTGSHSSEAGKKDVSG-----------------PLRELR-PRLCHLR 155
            P+  P    P  A   + S       V G                 P+ E+R PR     
Sbjct: 956  PSPLP-HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA---- 1010

Query: 156  KGPQGYGFNLHSDKS-------RPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLR 208
             GP G      SD S        PG +I  V P   AARSGLR  DR++ VNGQ+V    
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070

Query: 209  HAEVVASIKAREDEARLLV 227
            H E V+++     E  LLV
Sbjct: 1071 HQEAVSALLRPCLELSLLV 1089



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 77/283 (27%), Positives = 120/283 (42%), Gaps = 47/283 (16%)

Query: 14  LVRGEQGYGFHLHGEKGR-------RGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
           ++R   G G  + G KG         G FI RV    PA  A +R GD+L+EVNGV ++G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
             HH+ V+ ++      ++ V         R R +     +    L P  D + P+    
Sbjct: 791 AEHHEAVEALRGAGTAVQMRV--------WRERMVEPENAVTITPLRP-EDDYSPRE--R 839

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDK-SRP------GQYIRSV 179
             G         +  GPLR+ R   C L +  +G GF++   K S P      G ++  +
Sbjct: 840 RGGGLRLPLLPPESPGPLRQ-RHVAC-LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRI 897

Query: 180 DPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKR 238
             G  A R+G L+  DR++ +NG +V   RH   V+ + A      LL+           
Sbjct: 898 AEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL----------- 946

Query: 239 LRVTPTEEHVEGPL-PSPVTNGTSP-AQLNGGSACSSRSDLPG 279
                 E    GPL PSP+ + + P A +   S  ++   +PG
Sbjct: 947 ------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPG 983



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 69/278 (24%), Positives = 100/278 (35%), Gaps = 57/278 (20%)

Query: 33   GQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQET 92
            G FI +V P   A  + LR GDR++ VNG +V   TH + V  +     +  LLV     
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094

Query: 93   DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
               LR     C ++     L  +                                     
Sbjct: 1095 PPGLRE---LCIQKAPGERLGIS------------------------------------- 1114

Query: 153  HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
             +R G +G+  N   D +  G +I  V P   A R G LR   RL+EVN Q++ GL H E
Sbjct: 1115 -IRGGARGHAGNPR-DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 212  VVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSAC 271
             V  +++  D   +LV D         L V+P      G + +P   G            
Sbjct: 1173 AVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAGIGHR-------- 1218

Query: 272  SSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEA 309
            +S   +   D++       K+       LH  P A EA
Sbjct: 1219 NSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEA 1256


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 81/259 (31%), Positives = 105/259 (40%), Gaps = 56/259 (21%)

Query: 3    APEPLRPR-LCRLVRGEQGYGFHLHGEKGRR-------GQFIRRVEPGSPAE-AAALRAG 53
            +P PLR R +  L R E+G GF + G KG         G F+ R+  G  A  A  L+ G
Sbjct: 853  SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912

Query: 54   DRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP 113
            DR++ +NGV+V    H   V  + A      LL+                 E  A   LP
Sbjct: 913  DRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-----------------EREAGGPLP 955

Query: 114  PAHDPWEPKPDWAHTGSHSSEAGKKDVSG-----------------PLRELR-PRLCHLR 155
            P+  P    P  A   + S       V G                 P+ E+R PR     
Sbjct: 956  PSPLP-HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA---- 1010

Query: 156  KGPQGYGFNLHSDKS-------RPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLR 208
             GP G      SD S        PG +I  V P   AARSGLR  DR++ VNGQ+V    
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070

Query: 209  HAEVVASIKAREDEARLLV 227
            H E V+++     E  LLV
Sbjct: 1071 HQEAVSALLRPCLELSLLV 1089



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 77/283 (27%), Positives = 120/283 (42%), Gaps = 47/283 (16%)

Query: 14  LVRGEQGYGFHLHGEKGR-------RGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
           ++R   G G  + G KG         G FI RV    PA  A +R GD+L+EVNGV ++G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
             HH+ V+ ++      ++ V         R R +     +    L P  D + P+    
Sbjct: 791 AEHHEAVEALRGAGTAVQMRV--------WRERMVEPENAVTITPLRP-EDDYSPRE--R 839

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDK-SRP------GQYIRSV 179
             G         +  GPLR+ R   C L +  +G GF++   K S P      G ++  +
Sbjct: 840 RGGGLRLPLLPPESPGPLRQ-RHVAC-LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRI 897

Query: 180 DPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKR 238
             G  A R+G L+  DR++ +NG +V   RH   V+ + A      LL+           
Sbjct: 898 AEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL----------- 946

Query: 239 LRVTPTEEHVEGPL-PSPVTNGTSP-AQLNGGSACSSRSDLPG 279
                 E    GPL PSP+ + + P A +   S  ++   +PG
Sbjct: 947 ------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPG 983



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 69/278 (24%), Positives = 100/278 (35%), Gaps = 57/278 (20%)

Query: 33   GQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQET 92
            G FI +V P   A  + LR GDR++ VNG +V   TH + V  +     +  LLV     
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094

Query: 93   DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
               LR     C ++     L  +                                     
Sbjct: 1095 PPGLRE---LCIQKAPGERLGIS------------------------------------- 1114

Query: 153  HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
             +R G +G+  N   D +  G +I  V P   A R G LR   RL+EVN Q++ GL H E
Sbjct: 1115 -IRGGARGHAGNPR-DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 212  VVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSAC 271
             V  +++  D   +LV D         L V+P      G + +P   G            
Sbjct: 1173 AVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAGIGHR-------- 1218

Query: 272  SSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEA 309
            +S   +   D++       K+       LH  P A EA
Sbjct: 1219 NSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEA 1256


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 71/289 (24%), Positives = 126/289 (43%), Gaps = 28/289 (9%)

Query: 32   RGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQRIK-----------AV 79
            +G FI++V   SPA +  AL+ GD+++EV+GV+++  +H + V+ IK           ++
Sbjct: 1100 KGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSL 1159

Query: 80   EGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKD 139
                R++        ++   Q   T+E  ++    A  P +  P +      S E  ++D
Sbjct: 1160 SSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEED 1219

Query: 140  VSGPLRELRPR---------LCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPAARS 188
                 +++R R         +  L K   G G +L  + D+SR   ++  ++P  PAA  
Sbjct: 1220 AFTD-QKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1278

Query: 189  G-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
            G +R  D L+E+N Q + G  H    A IK    + +L+ +    ++   ++ VTP    
Sbjct: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI--RNEDAVNQMAVTPFPVP 1336

Query: 248  VEGPLPSPVTNGTSP-AQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPF 295
               P      +GT P +    GS       LP S+      S  KQ  +
Sbjct: 1337 SSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKY 1385



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 74/308 (24%), Positives = 128/308 (41%), Gaps = 35/308 (11%)

Query: 14  LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
           L+    G GF + G K   G  +R + PG  A+    L+ GD ++++ G NV+G T  QV
Sbjct: 251 LINDGSGLGFGIVGGK-TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQV 309

Query: 73  VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP---PAHDPWEPKPDWAHTG 129
            Q ++      R+LV      +             A   LP   P      P  D +   
Sbjct: 310 AQVLRNCGNSVRMLVARDPAGD-------ISVTPPAPAALPVALPTVASKGPGSDSSLFE 362

Query: 130 SHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG 189
           +++ E  +KD     + L  R+        GY    H+ ++  G Y++S+ PGS A  +G
Sbjct: 363 TYNVELVRKDG----QSLGIRIV-------GYVGTSHTGEA-SGIYVKSIIPGSAAYHNG 410

Query: 190 -LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
            ++  D+++ V+G N++G  + +VV  ++       L +V  +T      L        V
Sbjct: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470

Query: 249 EGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDG-SAWKQDPFQE-SGLHLSPTA 306
             PL  P    T         A  + +++ G D++ ++     K D  Q    L   P +
Sbjct: 471 VEPLKPPALFLT--------GAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDS 522

Query: 307 AEAKEKAR 314
            E + K+R
Sbjct: 523 PENELKSR 530



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 53/211 (25%), Positives = 91/211 (43%), Gaps = 16/211 (7%)

Query: 19   QGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIK 77
            +G G  + G++   G FI  +  G  A+    L  GD+++ VNG ++   +   V   +K
Sbjct: 1542 RGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601

Query: 78   AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGK 137
              +G  +L +           R    T + +Q     AH    P      TG  +   G 
Sbjct: 1602 CAQGLVQLEIGRLRAGSWTSART---TSQNSQGSQQSAHSSCHPSFAPVITGLQNL-VGT 1657

Query: 138  KDVSGPLR-----ELRPRLCHL-RKGPQGYGFNLHSDKSRP----GQYIRSVDPGSPAAR 187
            K VS P +     ++ PR   + R+     G ++   +  P      +I  +     AAR
Sbjct: 1658 KRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAAR 1717

Query: 188  SG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
            +  L+  DR++ +NGQ ++GL HA+VV  +K
Sbjct: 1718 TQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 60/282 (21%), Positives = 102/282 (36%), Gaps = 61/282 (21%)

Query: 11   LCRLVRGEQGYGFHLHGEKGRRGQ--FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
            +  L + + G G  L G K R     F+  + P  PA A   +R GD L+E+N   + G 
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298

Query: 68   THHQVVQRIKAVEGQTRLLVV-----------------------------------DQET 92
            +H      IK    + +L+ +                                   +++ 
Sbjct: 1299 SHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDG 1358

Query: 93   DEELRRRQLTCTE-------EMAQRGLP-------------PAHDPWEPKPDWAHTGSHS 132
              E+  +QL  +E       +M Q+  P             PA        D+   G   
Sbjct: 1359 SVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQ 1418

Query: 133  SEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP--GQYIRSVDPGSPAARSG- 189
            +       + P+   +  +  + KG  G G ++   K  P     I  V     AAR G 
Sbjct: 1419 APLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGR 1478

Query: 190  LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
            L A D+++EVNG ++    H E + +++    + RL+V   E
Sbjct: 1479 LWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE 1520



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 24/193 (12%)

Query: 35  FIRRVEPGSPAEAAAL-RAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETD 93
           +I  +  G P +   L +  D L+EVNG+ + G++  + V  +K V     L+   +  D
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641

Query: 94  EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRP--RL 151
           +E    +   TE               P+ +  H    ++E   +D  G L    P  ++
Sbjct: 642 DEASVDEPRRTETSL------------PETEVDHNMDVNTE---EDDDGELALWSPEVKI 686

Query: 152 CHLRKGPQGYGFNLHS-----DKSRPGQYIRSVDPGSPAARS-GLRAQDRLIEVNGQNVE 205
             L K  +G GF++       D +R    IRS+     A RS GL   DRL+ VN   ++
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746

Query: 206 GLRHAEVVASIKA 218
               AE V  +KA
Sbjct: 747 NTSLAEAVEILKA 759



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 6/113 (5%)

Query: 6    PLRPRLCRLVRGEQGYGFHLHGEKGR--RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGV 62
            P +  +  + +G  G G  + G K        I  V E G+ A    L AGD+++EVNGV
Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV 1491

Query: 63   NVEGETHHQVVQRIKAVEGQTRLLVVDQET---DEELRRRQLTCTEEMAQRGL 112
            ++   +H + +  ++    + RL+V   E    DEE         ++ A RGL
Sbjct: 1492 DLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGL 1544



 Score = 35.4 bits (80), Expect = 0.073
 Identities = 18/47 (38%), Positives = 26/47 (55%)

Query: 42   GSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
            G  A    L+ GDR+V +NG  ++G +H  VV  +K   G+  L VV
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 67/296 (22%), Positives = 116/296 (39%), Gaps = 20/296 (6%)

Query: 36   IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
            I R+  GSPA+    L+ GDR++ VNG ++  ++H  +V  IK       L ++    DE
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1066

Query: 95   ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
                  LT  E++A   +   H P +         +   +  + +   P   +E      
Sbjct: 1067 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1124

Query: 153  HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
             L +G +G+GF+L   +      Y+  +    PA R G +R  D ++E+NG+  + ++H+
Sbjct: 1125 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1184

Query: 211  EVVASIKAREDEARLLV---------VDPETDEHFKRLRVTPTEEHVEGP--LPSPVTNG 259
              +  IK      RL +          DP +D H          E   GP     P    
Sbjct: 1185 RAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLES 1244

Query: 260  TSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARA 315
            + P  L+  S    +       K + + S    +    +G    P +   + K RA
Sbjct: 1245 SYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRA 1300



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)

Query: 13  RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
           +L +  +G+GF + G  E     Q    V  G  A    +  GD +V VN   V G TH 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 71  QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
           QVV+  +++        +    D EL      C      RG P   DP +P         
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574

Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
                         +    SHSS+ GK  V+G +++ RP                     
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631

Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
                        H+ KGP G+GF +       GQ ++ +   SP  R GL+  D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689

Query: 200 NGQNVEGLRHAEVV 213
           N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 71/288 (24%), Positives = 115/288 (39%), Gaps = 50/288 (17%)

Query: 14  LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
           +V+G  G+GF +    G  GQ ++++   SP     L+ GD +VEVN  NV+  TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703

Query: 74  QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAHD 117
              ++  +G    L+V +               E  +     Q + +   +     P+H 
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763

Query: 118 PW---EPKPDWAHTGSHSSEAGKKD-------------VSGPLRELRPRLCHLRKGPQGY 161
                E  P  A     +  +G+K                  L + + +   L +   G+
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGF 823

Query: 162 GFNLHSDKSRPGQ--YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK- 217
           GF +    + PG+  YI  + P   A   G LR+ D LI V+G  V G  H  VV  ++ 
Sbjct: 824 GFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882

Query: 218 -AREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQ 264
            A++    L V          R +V       E  +PSP ++  S  Q
Sbjct: 883 AAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQ 920


>gi|31742501 sorting nexin family member 27 [Homo sapiens]
          Length = 528

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 39/93 (41%), Positives = 53/93 (56%), Gaps = 13/93 (13%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQF-------------IRRVEPGSPAEAAALRAGDR 55
           PR+ R+V+ E GYGF++ G+    GQ              +  V PG  A+ A +R GDR
Sbjct: 41  PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100

Query: 56  LVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
           ++EVN VNVEG TH QVV  I+A E +  L V+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 13/93 (13%)

Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-------------YIRSVDPGSPAARSGLRAQDR 195
           PR+  + K   GYGFN+    S  GQ             ++ +V PG  A R+G+R  DR
Sbjct: 41  PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100

Query: 196 LIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
           ++EVN  NVEG  H +VV  I+A E E  L V+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 59/200 (29%), Positives = 90/200 (45%), Gaps = 27/200 (13%)

Query: 35   FIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETD 93
            FI  + P G  A+   LR GDR+V + G + EG TH Q V  +K   G   + VV     
Sbjct: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDV 1921

Query: 94   EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCH 153
              +   Q    +E A   L             + TG  SS   + D+  P    + +   
Sbjct: 1922 SVVTGHQ----QEPASSSL-------------SFTGLTSSSIFQDDLGPP----QCKSIT 1960

Query: 154  LRKGPQGYGFNLHSDKSRPGQ----YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLR 208
            L +GP G GF++      P      Y+++V     A+  G L+  D++I VNGQ++EG+ 
Sbjct: 1961 LERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVT 2020

Query: 209  HAEVVASIKAREDEARLLVV 228
            H E VA +K  +    L+V+
Sbjct: 2021 HEEAVAILKRTKGTVTLMVL 2040



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 69/293 (23%), Positives = 116/293 (39%), Gaps = 55/293 (18%)

Query: 17   GEQGYGFHLHGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
            G +G G  L   +  RG FI+ V   SPA +   L+ GDR+VEV+G+++   +H Q V+ 
Sbjct: 1168 GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEA 1227

Query: 76   IKAVEGQTRLLVVD-----------------------QETDEELRRRQLTCTEEMAQRGL 112
            I+        +V                           T+      Q+   +  +Q   
Sbjct: 1228 IRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSES 1287

Query: 113  PPAHDPW-----EPKPDWAHTGSHSSEAGKKDVSGPL----------RELRPR------- 150
             P   P       P   +A  GS  +++    +S  +          + +R R       
Sbjct: 1288 EPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGE 1347

Query: 151  --LCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVE 205
              +  L KG  G G +L  + D+SR   +I  +DP   A + G L+  D L+E+NGQ + 
Sbjct: 1348 LHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407

Query: 206  GLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
            G  H    + IK    + +++ +     +   ++ V P   +   PLPS   N
Sbjct: 1408 GRSHQNASSIIKCAPSKVKIIFI--RNKDAVNQMAVCP--GNAVEPLPSNSEN 1456



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 71/234 (30%), Positives = 98/234 (41%), Gaps = 34/234 (14%)

Query: 20  GYGFHLHGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQRIKA 78
           G G  L    G    FIR V P  P   +  L +GD L+EVNG+ + GE H  VV  +K 
Sbjct: 564 GLGISLEATVGHH--FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKE 621

Query: 79  VEGQTRLL----VVDQETDEELRRRQLTCTEEMAQR---------GLPPAHDPWEPKPDW 125
           +  +  ++     V   T  EL    L C  E+ ++         G     DP     D 
Sbjct: 622 LPIEVTMVCCRRTVPPTTQSELDSLDL-CDIELTEKPHVDLGEFIGSSETEDPVLAMTD- 679

Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCH--LRKGPQGYGFNL--HSDKSRPGQ---YIRS 178
                 S+E    +V  PL      + H  L KG +G GF++  + D   P      IRS
Sbjct: 680 ---AGQSTE----EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRS 732

Query: 179 VDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK-AREDEARLLVVDP 230
           + PG  A + G L   DRL+ VN  N+E     E V ++K A     R+ V  P
Sbjct: 733 LVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 62/274 (22%), Positives = 113/274 (41%), Gaps = 43/274 (15%)

Query: 14  LVRGEQGYGFHLHGEKGRR-----GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
           L +  QG G  + G  G +     G F++ +   S  E    ++ GD+++ V+G N++G 
Sbjct: 380 LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439

Query: 68  THHQVVQRIKAVEGQTRLLVV----DQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKP 123
           T+ Q V+ ++   GQT LL +     ++  E + R  +T   +++        + +E   
Sbjct: 440 TNQQAVEVLRHT-GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498

Query: 124 DWAHTGSHSS-----EAGKKDVSGPLRELRPR----------------------LCHLRK 156
           D+  +  +++     E G   +S  + E+                         + H+ K
Sbjct: 499 DFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSK 558

Query: 157 GPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVAS 215
             +  G  +  + +    +IRSV P  P   SG L + D L+EVNG  + G  H +VV  
Sbjct: 559 FSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618

Query: 216 IKAREDEARLL----VVDPETDEHFKRLRVTPTE 245
           +K    E  ++     V P T      L +   E
Sbjct: 619 LKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 8/92 (8%)

Query: 5    EPLRPRLCR---LVRGEQGYGFHLHGEKGR-RGQ---FIRRV-EPGSPAEAAALRAGDRL 56
            + L P  C+   L RG  G GF + G  G   G    +++ V   G+ +E   L+ GD++
Sbjct: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008

Query: 57   VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
            + VNG ++EG TH + V  +K  +G   L+V+
Sbjct: 2009 IAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 47/217 (21%), Positives = 82/217 (37%), Gaps = 41/217 (18%)

Query: 19   QGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIK 77
            +G G  + G++   G F+  +  G  A+A   L  GD+++ VNG +V   T   V   +K
Sbjct: 1734 KGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793

Query: 78   AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGK 137
              EG                                       P    + + S  S + K
Sbjct: 1794 VSEGSLSSFTF--------------------------------PLSGSSTSESLESSSKK 1821

Query: 138  KDVSGPLRELRPRLCHLRKGP-QGYGFNLHSDKSRP----GQYIRSVDPGSPAARS-GLR 191
              ++  ++ L  R   ++KGP    G ++      P      +I  + P   AA++  LR
Sbjct: 1822 NALASEIQGL--RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879

Query: 192  AQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
              DR++ + G + EG+ H + V  +K       + VV
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 60/289 (20%), Positives = 109/289 (37%), Gaps = 26/289 (8%)

Query: 10   RLCRLVRGEQGYGFHLHGEKGRRGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGET 68
            R   + +G    G  +   K   G  +R +   G+ +    +  GD ++ +N  +    T
Sbjct: 1007 RTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVT 1066

Query: 69   HHQ---VVQRIKAVEGQTRLLVVDQETDEEL---------RRRQLTCTEEMAQRGLP--P 114
            + Q   +++R   +    ++  V  E  EE          R   L        R +P  P
Sbjct: 1067 NAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELP 1126

Query: 115  AHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ 174
              +  E +       ++S+    + V    RE    L     G +G G  L + +   G 
Sbjct: 1127 EREEGEGEESELQNTAYSNWNQPRRVE-LWREPSKSLGISIVGGRGMGSRLSNGEVMRGI 1185

Query: 175  YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETD 233
            +I+ V   SPA ++G L+  DR++EV+G ++    H + V +I+   +    +V      
Sbjct: 1186 FIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV-----Q 1240

Query: 234  EHFKRLRVTPTEEHVEGPLPSPVTNGTSP----AQLNGGSACSSRSDLP 278
                R R +P    +    P    + T+P     Q+N   A S     P
Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEP 1289



 Score = 36.6 bits (83), Expect = 0.033
 Identities = 35/182 (19%), Positives = 66/182 (36%), Gaps = 47/182 (25%)

Query: 40   EPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRR 99
            E G+  +   L AGD+++EVNG+++   TH + +  ++    + RL +   E   +    
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV 1720

Query: 100  QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQ 159
              T T E+                                               +K  +
Sbjct: 1721 CDTLTIELQ----------------------------------------------KKPGK 1734

Query: 160  GYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
            G G ++   ++  G ++  +  G  A   G L   D+++ VNG++V       V A +K 
Sbjct: 1735 GLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794

Query: 219  RE 220
             E
Sbjct: 1795 SE 1796



 Score = 33.9 bits (76), Expect = 0.21
 Identities = 47/227 (20%), Positives = 83/227 (36%), Gaps = 9/227 (3%)

Query: 14   LVRGEQGYGFHLHGEKGRRGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGETHHQV 72
            L + + G G  +  E    G  I+ + E G  A    L+ GD+++ V+   V G    + 
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545

Query: 73   VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE--PKPDWAHTGS 130
            +  +K  +   +L +  +  D +             +        P    P+P+     S
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605

Query: 131  HSSEAG---KKDVSGPLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPA 185
             SS          + P+         + KG  G G ++   SD       I  V     A
Sbjct: 1606 RSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAA 1665

Query: 186  ARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
             + G L A D+++EVNG ++    H E +  ++      RL +   E
Sbjct: 1666 CKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDE 1712



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 21/97 (21%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 145  RELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQN 203
            +E   R  ++ KG    G  + ++K   G  +RS+  G   +R G +   D ++ +N ++
Sbjct: 1002 KESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061

Query: 204  VEGLRHAEVVASIKARE---DEARLLVVDPETDEHFK 237
               + +A+  A ++       + ++  V  E  E FK
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFK 1098


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 79/271 (29%), Positives = 114/271 (42%), Gaps = 47/271 (17%)

Query: 14   LVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQ 71
            L R E G+GF + G  E G+       +  GS      L  GD LV V+G+ V G+TH  
Sbjct: 781  LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840

Query: 72   VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE---PKPDWA 126
            V+  +   A  GQ  L V         RR+ L   E   + G  P         P+ D+A
Sbjct: 841  VIDLMHHAARNGQVNLTV---------RRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYA 891

Query: 127  HTGSHSSEAGKKDVSGPLRELRPRLCHL------RKGPQGYGFNLHSDKSRPGQ------ 174
             T ++S+ A     + P                 RK  +G+GF + S  +RP        
Sbjct: 892  -TYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITV 950

Query: 175  --YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
               I  +  GSPA R   L+  DR++ VNGQ++  + HA++V  IK    +A L V    
Sbjct: 951  PHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK----DAGLSVT--- 1003

Query: 232  TDEHFKRLRVTPTEEHVEGPLPSPVTNGTSP 262
                   LR+ P EE +  P  +P +   SP
Sbjct: 1004 -------LRIIPQEE-LNSPTSAPSSEKQSP 1026



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 7/88 (7%)

Query: 154  LRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
            + KG +G+GF++   +  +   Y+  +    PA R+G +R  D++IE+NG++   + HA 
Sbjct: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209

Query: 212  VVASIKAREDEARLLVVD-----PETDE 234
             +  IK+     RLL+       PE DE
Sbjct: 1210 AIELIKSGGRRVRLLLKRGTGQVPEYDE 1237



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 62/243 (25%), Positives = 100/243 (41%), Gaps = 51/243 (20%)

Query: 14  LVRGEQGYGFHL-HGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQV 72
           +V+G QG+GF +     G+R + I  ++ G P     L  GD +VE+N  NV+  +H +V
Sbjct: 608 IVKGAQGFGFTIADSPTGQRVKQILDIQ-GCPG----LCEGDLIVEINQQNVQNLSHTEV 662

Query: 73  VQRIK--AVEGQTRLL---------------VVDQETDEELRRRQLTCTEEMAQRGLPP- 114
           V  +K   +  +T L+               ++D+  ++   +  L+          PP 
Sbjct: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722

Query: 115 -----------AHDPWEPKPDWAHTGSHSSEAGKK----------DVSGPLRELRPRLCH 153
                      A DP +P P   +  S +    ++          D SGP  + +    H
Sbjct: 723 LHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGP--DYKELDVH 780

Query: 154 LRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
           LR+   G+GF +      PGQ   I +V     A R G L   D L+ V+G  V G  H 
Sbjct: 781 LRRMESGFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHR 839

Query: 211 EVV 213
            V+
Sbjct: 840 YVI 842



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 64/252 (25%), Positives = 95/252 (37%), Gaps = 61/252 (24%)

Query: 14  LVRGEQGYGFHL-HGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQ 71
           L +   G+GF +  G++      ++ V P  PA +   +  GD +V +N V V G TH  
Sbjct: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488

Query: 72  VVQRIKAVE-GQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGS 130
           VV+  ++V  GQ+  LV+        R   L    E     + P     E  P     G 
Sbjct: 489 VVKLFQSVPIGQSVNLVL-------CRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGR 541

Query: 131 HSSEAGKKDVS-----------------------GPLRELRPRLCH-------------- 153
           H+ E   + +S                       G L    P   H              
Sbjct: 542 HNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQA 601

Query: 154 ------LRKGPQGYGFNLHSDKSRPGQYIRSV--DPGSPAARSGLRAQDRLIEVNGQNVE 205
                 + KG QG+GF +    S  GQ ++ +    G P    GL   D ++E+N QNV+
Sbjct: 602 ELMTLTIVKGAQGFGFTIAD--SPTGQRVKQILDIQGCP----GLCEGDLIVEINQQNVQ 655

Query: 206 GLRHAEVVASIK 217
            L H EVV  +K
Sbjct: 656 NLSHTEVVDILK 667



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 21/74 (28%), Positives = 40/74 (54%), Gaps = 2/74 (2%)

Query: 16   RGEQGYGFHLHGEKGRRGQF--IRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
            +G +G+GF + G +  +     +R  E G       +R GD+++E+NG +    TH + +
Sbjct: 1152 KGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAI 1211

Query: 74   QRIKAVEGQTRLLV 87
            + IK+   + RLL+
Sbjct: 1212 ELIKSGGRRVRLLL 1225


>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
           sapiens]
          Length = 907

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 64/235 (27%), Positives = 100/235 (42%), Gaps = 37/235 (15%)

Query: 2   AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRR-GQFIRRVEPGSPAEAAALRAGDRLVEVN 60
           A P  +R    R  +  +G GF + G      G ++  VEPGS AE   LR GD+++ VN
Sbjct: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192

Query: 61  GVNVEGETHHQVVQRIKAVEGQTRLLV----VDQETDEELRRRQLTCTEEMAQRGLPPAH 116
             ++   TH    + +KA++G  +L++      +     +     T  +   +   PP+ 
Sbjct: 193 DKSLARVTH---AEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSG 249

Query: 117 DPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP---- 172
            P +P     H G+   + G           R    HL +G      NL     R     
Sbjct: 250 LP-QP-----HGGALRQQEGD----------RRSTLHLLQGGDEKKVNLVLGDGRSLGLT 293

Query: 173 ---------GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
                    G YI  VDPGS A  SGL+  D+++EVNG++   + H E V  +K+
Sbjct: 294 IRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 13/122 (10%)

Query: 97  RRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRK 156
           R  QL   +  A+    PA  P+  +P W          G  D +GP  E+R       K
Sbjct: 100 RSDQLLFDQYTAEGLYLPATTPYR-QPAW----------GGPDSAGP-GEVRLVSLRRAK 147

Query: 157 GPQGYGFNLHSDKSRP-GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVAS 215
             +G GF++        G Y+  V+PGS A + GLR  D+++ VN +++  + HAE V +
Sbjct: 148 AHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKA 207

Query: 216 IK 217
           +K
Sbjct: 208 LK 209


>gi|41281808 harmonin isoform b3 [Homo sapiens]
          Length = 899

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)

Query: 6   PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
           P R R  + VR +    +G G  + G  E G  G FI  +  G  A++  L+ GD +V +
Sbjct: 79  PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137

Query: 60  NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
           NG ++   TH +V+  I                     R + T + ++   GL P     
Sbjct: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176

Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
           +    W +     SE+G   V G L     RE + +   +   G +G G ++ S    +P
Sbjct: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234

Query: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
           G +I  V PGS +A  GL   D+++EVNG +   L H E V  +K+
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 17  GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
           G +G G  +  G   + G FI  V+PGS +    L  GD++VEVNGV+     H + V  
Sbjct: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277

Query: 76  IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
           +K+    T          L + D+E   E R+R+L   E + Q+ L
Sbjct: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323



 Score = 33.9 bits (76), Expect = 0.21
 Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)

Query: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
           S  L+E+R    H    P+G G ++    +   G +I  +  G  A   GL+  D ++ +
Sbjct: 82  SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137

Query: 200 NGQNVEGLRHAEVVASIKARE 220
           NG ++    H EV+  I+ ++
Sbjct: 138 NGYSISSCTHEEVINLIRTKK 158


>gi|71480164 harmonin isoform a [Homo sapiens]
          Length = 552

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)

Query: 6   PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
           P R R  + VR +    +G G  + G  E G  G FI  +  G  A++  L+ GD +V +
Sbjct: 79  PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137

Query: 60  NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
           NG ++   TH +V+  I                     R + T + ++   GL P     
Sbjct: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176

Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
           +    W +     SE+G   V G L     RE + +   +   G +G G ++ S    +P
Sbjct: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234

Query: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
           G +I  V PGS +A  GL   D+++EVNG +   L H E V  +K+
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 17  GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
           G +G G  +  G   + G FI  V+PGS +    L  GD++VEVNGV+     H + V  
Sbjct: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277

Query: 76  IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
           +K+    T          L + D+E   E R+R+L   E + Q+ L
Sbjct: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323



 Score = 33.9 bits (76), Expect = 0.21
 Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)

Query: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
           S  L+E+R    H    P+G G ++    +   G +I  +  G  A   GL+  D ++ +
Sbjct: 82  SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137

Query: 200 NGQNVEGLRHAEVVASIKARE 220
           NG ++    H EV+  I+ ++
Sbjct: 138 NGYSISSCTHEEVINLIRTKK 158


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 49/197 (24%), Positives = 88/197 (44%), Gaps = 9/197 (4%)

Query: 36   IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
            I R+  GSPA+    L+ GDR++ VNG ++  ++H  +V  IK       L ++    DE
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1095

Query: 95   ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
                  LT  E++A   +   H P +         +   +  + +   P   +E      
Sbjct: 1096 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1153

Query: 153  HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
             L +G +G+GF+L   +      Y+  +    PA R G +R  D ++E+NG+  + ++H+
Sbjct: 1154 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1213

Query: 211  EVVASIKAREDEARLLV 227
              +  IK      RL +
Sbjct: 1214 RAIELIKNGGRRVRLFL 1230



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)

Query: 13  RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
           +L +  +G+GF + G  E     Q    V  G  A    +  GD +V VN   V G TH 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 71  QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
           QVV+  +++        +    D EL      C      RG P   DP +P         
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574

Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
                         +    SHSS+ GK  V+G +++ RP                     
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631

Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
                        H+ KGP G+GF +       GQ ++ +   SP  R GL+  D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689

Query: 200 NGQNVEGLRHAEVV 213
           N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 67/258 (25%), Positives = 108/258 (41%), Gaps = 53/258 (20%)

Query: 14   LVRGEQGYGFH-LHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQ 71
            L R E G+GF  L G +     +I  + P   A+    LR+GD L+ V+G  V G++H  
Sbjct: 844  LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903

Query: 72   VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP-PA---HDPWEPK--- 122
            VVQ ++  A +G   L V          RR++       +  +P PA   H   +P    
Sbjct: 904  VVQLMQQAAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQPASLT 953

Query: 123  -----PDWAHTGSHSSEAGKKDVSG-----------PLRELRPRLCHLRKGP-QGYGFNL 165
                 P  +    ++  +G    SG               ++P    +R+G  +G+GF +
Sbjct: 954  EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVI 1013

Query: 166  HSDKSRPG--------------QYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
             S  SRP                 I  +  GSPA R G L+  DR++ VNG ++    H+
Sbjct: 1014 VSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHS 1073

Query: 211  EVVASIKAREDEARLLVV 228
            ++V  IK   +   L ++
Sbjct: 1074 DIVNLIKEAGNTVTLRII 1091



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 74/316 (23%), Positives = 119/316 (37%), Gaps = 78/316 (24%)

Query: 14  LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
           +V+G  G+GF +    G  GQ ++++   SP     L+ GD +VEVN  NV+  TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703

Query: 74  QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAH- 116
              ++  +G    L+V +               E  +     Q + +   +     P+H 
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763

Query: 117 -------------------DPWEPKPD----WAHTGS--HSSEAGKKDVSG--------- 142
                                 + KPD    WA + S   +        SG         
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823

Query: 143 ---------PLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-L 190
                    P+ + + +   L +   G+GF +    + PG+  YI  + P   A   G L
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRL 882

Query: 191 RAQDRLIEVNGQNVEGLRHAEVVASIK--AREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
           R+ D LI V+G  V G  H  VV  ++  A++    L V          R +V       
Sbjct: 883 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV----------RRKVVFAVPKT 932

Query: 249 EGPLPSPVTNGTSPAQ 264
           E  +PSP ++  S  Q
Sbjct: 933 ENEVPSPASSHHSSNQ 948


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 49/197 (24%), Positives = 88/197 (44%), Gaps = 9/197 (4%)

Query: 36   IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
            I R+  GSPA+    L+ GDR++ VNG ++  ++H  +V  IK       L ++    DE
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1094

Query: 95   ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
                  LT  E++A   +   H P +         +   +  + +   P   +E      
Sbjct: 1095 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1152

Query: 153  HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
             L +G +G+GF+L   +      Y+  +    PA R G +R  D ++E+NG+  + ++H+
Sbjct: 1153 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1212

Query: 211  EVVASIKAREDEARLLV 227
              +  IK      RL +
Sbjct: 1213 RAIELIKNGGRRVRLFL 1229



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)

Query: 13  RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
           +L +  +G+GF + G  E     Q    V  G  A    +  GD +V VN   V G TH 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 71  QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
           QVV+  +++        +    D EL      C      RG P   DP +P         
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574

Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
                         +    SHSS+ GK  V+G +++ RP                     
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631

Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
                        H+ KGP G+GF +       GQ ++ +   SP  R GL+  D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689

Query: 200 NGQNVEGLRHAEVV 213
           N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 67/257 (26%), Positives = 108/257 (42%), Gaps = 52/257 (20%)

Query: 14   LVRGEQGYGFH-LHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQ 71
            L R E G+GF  L G +     +I  + P   A+    LR+GD L+ V+G  V G++H  
Sbjct: 844  LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903

Query: 72   VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP-PA---HDPWEPK--- 122
            VVQ ++  A +G   L V          RR++       +  +P PA   H   +P    
Sbjct: 904  VVQLMQQAAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQPASLT 953

Query: 123  -----PDWAHTGSHSSEAGKKDVSG-----------PLRELRPRLCHLRKGP-QGYGFNL 165
                 P  +    ++  +G    SG               ++P    +R+G  +G+GF +
Sbjct: 954  EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVI 1013

Query: 166  HSDKSRPG-------------QYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
             S  SRP                I  +  GSPA R G L+  DR++ VNG ++    H++
Sbjct: 1014 VSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSD 1073

Query: 212  VVASIKAREDEARLLVV 228
            +V  IK   +   L ++
Sbjct: 1074 IVNLIKEAGNTVTLRII 1090



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 74/316 (23%), Positives = 119/316 (37%), Gaps = 78/316 (24%)

Query: 14  LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
           +V+G  G+GF +    G  GQ ++++   SP     L+ GD +VEVN  NV+  TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703

Query: 74  QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAH- 116
              ++  +G    L+V +               E  +     Q + +   +     P+H 
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763

Query: 117 -------------------DPWEPKPD----WAHTGS--HSSEAGKKDVSG--------- 142
                                 + KPD    WA + S   +        SG         
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823

Query: 143 ---------PLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-L 190
                    P+ + + +   L +   G+GF +    + PG+  YI  + P   A   G L
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRL 882

Query: 191 RAQDRLIEVNGQNVEGLRHAEVVASIK--AREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
           R+ D LI V+G  V G  H  VV  ++  A++    L V          R +V       
Sbjct: 883 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV----------RRKVVFAVPKT 932

Query: 249 EGPLPSPVTNGTSPAQ 264
           E  +PSP ++  S  Q
Sbjct: 933 ENEVPSPASSHHSSNQ 948


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 33/81 (40%), Positives = 53/81 (65%), Gaps = 2/81 (2%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQ-FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
           PR+  L + E+G GF++ G K +    +I R+ PG  A+    L+ GD+L+ VNGV+VEG
Sbjct: 91  PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150

Query: 67  ETHHQVVQRIKAVEGQTRLLV 87
           E H + V+ +KA +G+ +L+V
Sbjct: 151 EHHEKAVELLKAAQGKVKLVV 171



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 35/99 (35%), Positives = 54/99 (54%), Gaps = 7/99 (7%)

Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-YIRSVDPGSPAAR-SGLRAQDRLIEVNGQNVEG 206
           PR+  L K  +G GFN+   K +    YI  + PG  A R  GL+  D+L+ VNG +VEG
Sbjct: 91  PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150

Query: 207 LRHAEVVASIKAREDEARLLV-----VDPETDEHFKRLR 240
             H + V  +KA + + +L+V     V  E +  F+++R
Sbjct: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 33/81 (40%), Positives = 52/81 (64%), Gaps = 2/81 (2%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQ-FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
           PR+  L + ++G GF++ G K +    +I RV PG  A+    L+ GD+L+ VNGV+VEG
Sbjct: 91  PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150

Query: 67  ETHHQVVQRIKAVEGQTRLLV 87
           E H + V+ +KA +G  +L+V
Sbjct: 151 EQHEKAVELLKAAQGSVKLVV 171



 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 36/99 (36%), Positives = 54/99 (54%), Gaps = 7/99 (7%)

Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-YIRSVDPGSPAAR-SGLRAQDRLIEVNGQNVEG 206
           PR+  L K  +G GFN+   K +    YI  V PG  A R  GL+  D+L+ VNG +VEG
Sbjct: 91  PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150

Query: 207 LRHAEVVASIKAREDEARLLV-----VDPETDEHFKRLR 240
            +H + V  +KA +   +L+V     V  E +  F+++R
Sbjct: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMR 189


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 64/264 (24%), Positives = 98/264 (37%), Gaps = 44/264 (16%)

Query: 4   PEPLRPRLCRLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRL 56
           P P       L++G +G GF + G  G +           + +E G+  +   L+ GDRL
Sbjct: 219 PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278

Query: 57  VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV------------------------DQET 92
           + VN  N++   H + V  +K       L V                         D   
Sbjct: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHI 338

Query: 93  DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
                   L   E       PP   P    P   H         ++D +   RE  PR  
Sbjct: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHM------LAEEDFT---RE--PRKI 387

Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
            L KG  G GFN+   +   G ++  +  G PA  SG LR  DR++ VNG N+    H +
Sbjct: 388 ILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 447

Query: 212 VVASIKAREDEARLLVVDPETDEH 235
             A++K R  ++  +V     +E+
Sbjct: 448 AAAALK-RAGQSVTIVAQYRPEEY 470



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 64/231 (27%), Positives = 88/231 (38%), Gaps = 66/231 (28%)

Query: 14  LVRGEQGYGFHLHGEKGRR------GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
           L RG  G GF + G           G FI ++ PG  A     L   D ++ VN V+V  
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
             H + V+ +K      RL+V         RRRQ            PP     E      
Sbjct: 194 VVHSRAVEALKEAGPVVRLVV---------RRRQ------------PPPETIME------ 226

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
                                     +L KGP+G GF++     ++  PG    YI  + 
Sbjct: 227 -------------------------VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKII 261

Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDP 230
            G  A + G L+  DRL+ VN  N++ +RH E VAS+K   D   L V  P
Sbjct: 262 EGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
           PR   L +G  G GF++ G +   G F+  +  G PA+ +  LR GDR++ VNGVN+   
Sbjct: 384 PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNA 443

Query: 68  THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
           TH Q    +K   GQ+  +V     +E  R
Sbjct: 444 THEQAAAALKRA-GQSVTIVAQYRPEEYSR 472


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)

Query: 33   GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
            G +++ V P   AE+   +  GDR++ VNGV++EG TH Q V+ ++   GQ   L++++ 
Sbjct: 1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1457

Query: 92   TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
                 +       Q T +++ AQ   P          D++     ++   K         
Sbjct: 1458 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1508

Query: 147  LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
                   L K   G GF+    D   P Q       ++ + PG PAA SG +   D +++
Sbjct: 1509 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1561

Query: 199  VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
            VNG +++GL   EV+++++    E  LL+  P          V P    ++  L +P+  
Sbjct: 1562 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1609

Query: 259  GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
              SPAQ+           LP S KD+   S  +Q    +       +  + K  +R
Sbjct: 1610 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1653



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 20   GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
            G GF +  GEK  R   G FI  V PG PA+    L+ GDRL+ VN V++EG +HH  ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 75   RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
             ++ A E  T ++   +E   ++    +  T EM
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1196



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)

Query: 140  VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
            VS P RE+   L +L+K  + G GF +   +       G +I SV PG PA   G L+  
Sbjct: 1084 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 194  DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
            DRLI VN  ++EG+ H   +  ++   ++  L++  P+  E   ++  TP
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1189



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)

Query: 11   LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
            L  L++ E+G  GF +     R G ++  V          L+ GDRL++VN  +V   TH
Sbjct: 1793 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1852

Query: 70   HQVVQRIKAVEGQTRLLV 87
               V  ++A     RL++
Sbjct: 1853 TDAVNLLRAASKTVRLVI 1870



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)

Query: 112  LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
            LPP   P   ++P+ + A + S       H SE  +++   PL+              EL
Sbjct: 1733 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1792

Query: 148  RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
               L    KG    GF +     R G Y+  V      +   L+  DRLI+VN  +V  +
Sbjct: 1793 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1850

Query: 208  RHAEVVASIKAREDEARLLV 227
             H + V  ++A     RL++
Sbjct: 1851 THTDAVNLLRAASKTVRLVI 1870


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)

Query: 33   GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
            G +++ V P   AE+   +  GDR++ VNGV++EG TH Q V+ ++   GQ   L++++ 
Sbjct: 1203 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1261

Query: 92   TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
                 +       Q T +++ AQ   P          D++     ++   K         
Sbjct: 1262 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1312

Query: 147  LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
                   L K   G GF+    D   P Q       ++ + PG PAA SG +   D +++
Sbjct: 1313 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1365

Query: 199  VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
            VNG +++GL   EV+++++    E  LL+  P          V P    ++  L +P+  
Sbjct: 1366 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1413

Query: 259  GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
              SPAQ+           LP S KD+   S  +Q    +       +  + K  +R
Sbjct: 1414 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1457



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 20   GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
            G GF +  GEK  R   G FI  V PG PA+    L+ GDRL+ VN V++EG +HH  ++
Sbjct: 912  GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971

Query: 75   RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
             ++ A E  T ++   +E   ++    +  T EM
Sbjct: 972  ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1005



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)

Query: 140 VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
           VS P RE+   L +L+K  + G GF +   +       G +I SV PG PA   G L+  
Sbjct: 893 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950

Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
           DRLI VN  ++EG+ H   +  ++   ++  L++  P+  E   ++  TP
Sbjct: 951 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 998



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)

Query: 11   LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
            L  L++ E+G  GF +     R G ++  V          L+ GDRL++VN  +V   TH
Sbjct: 1597 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1656

Query: 70   HQVVQRIKAVEGQTRLLV 87
               V  ++A     RL++
Sbjct: 1657 TDAVNLLRAASKTVRLVI 1674



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)

Query: 112  LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
            LPP   P   ++P+ + A + S       H SE  +++   PL+              EL
Sbjct: 1537 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1596

Query: 148  RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
               L    KG    GF +     R G Y+  V      +   L+  DRLI+VN  +V  +
Sbjct: 1597 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1654

Query: 208  RHAEVVASIKAREDEARLLV 227
             H + V  ++A     RL++
Sbjct: 1655 THTDAVNLLRAASKTVRLVI 1674


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)

Query: 33   GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
            G +++ V P   AE+   +  GDR++ VNGV++EG TH Q V+ ++   GQ   L++++ 
Sbjct: 1394 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1452

Query: 92   TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
                 +       Q T +++ AQ   P          D++     ++   K         
Sbjct: 1453 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1503

Query: 147  LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
                   L K   G GF+    D   P Q       ++ + PG PAA SG +   D +++
Sbjct: 1504 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1556

Query: 199  VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
            VNG +++GL   EV+++++    E  LL+  P          V P    ++  L +P+  
Sbjct: 1557 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1604

Query: 259  GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
              SPAQ+           LP S KD+   S  +Q    +       +  + K  +R
Sbjct: 1605 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1648



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 20   GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
            G GF +  GEK  R   G FI  V PG PA+    L+ GDRL+ VN V++EG +HH  ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 75   RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
             ++ A E  T ++   +E   ++    +  T EM
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1196



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)

Query: 140  VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
            VS P RE+   L +L+K  + G GF +   +       G +I SV PG PA   G L+  
Sbjct: 1084 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 194  DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
            DRLI VN  ++EG+ H   +  ++   ++  L++  P+  E   ++  TP
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1189



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)

Query: 11   LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
            L  L++ E+G  GF +     R G ++  V          L+ GDRL++VN  +V   TH
Sbjct: 1788 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1847

Query: 70   HQVVQRIKAVEGQTRLLV 87
               V  ++A     RL++
Sbjct: 1848 TDAVNLLRAASKTVRLVI 1865



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)

Query: 112  LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
            LPP   P   ++P+ + A + S       H SE  +++   PL+              EL
Sbjct: 1728 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1787

Query: 148  RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
               L    KG    GF +     R G Y+  V      +   L+  DRLI+VN  +V  +
Sbjct: 1788 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1845

Query: 208  RHAEVVASIKAREDEARLLV 227
             H + V  ++A     RL++
Sbjct: 1846 THTDAVNLLRAASKTVRLVI 1865


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)

Query: 33   GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
            G +++ V P   AE+   +  GDR++ VNGV++EG TH Q V+ ++   GQ   L++++ 
Sbjct: 1375 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1433

Query: 92   TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
                 +       Q T +++ AQ   P          D++     ++   K         
Sbjct: 1434 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1484

Query: 147  LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
                   L K   G GF+    D   P Q       ++ + PG PAA SG +   D +++
Sbjct: 1485 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1537

Query: 199  VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
            VNG +++GL   EV+++++    E  LL+  P          V P    ++  L +P+  
Sbjct: 1538 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1585

Query: 259  GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
              SPAQ+           LP S KD+   S  +Q    +       +  + K  +R
Sbjct: 1586 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1629



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 20   GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
            G GF +  GEK  R   G FI  V PG PA+    L+ GDRL+ VN V++EG +HH  ++
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143

Query: 75   RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
             ++ A E  T ++   +E   ++    +  T EM
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1177



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)

Query: 140  VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
            VS P RE+   L +L+K  + G GF +   +       G +I SV PG PA   G L+  
Sbjct: 1065 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122

Query: 194  DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
            DRLI VN  ++EG+ H   +  ++   ++  L++  P+  E   ++  TP
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1170



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)

Query: 11   LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
            L  L++ E+G  GF +     R G ++  V          L+ GDRL++VN  +V   TH
Sbjct: 1769 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1828

Query: 70   HQVVQRIKAVEGQTRLLV 87
               V  ++A     RL++
Sbjct: 1829 TDAVNLLRAASKTVRLVI 1846



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)

Query: 112  LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
            LPP   P   ++P+ + A + S       H SE  +++   PL+              EL
Sbjct: 1709 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1768

Query: 148  RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
               L    KG    GF +     R G Y+  V      +   L+  DRLI+VN  +V  +
Sbjct: 1769 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1826

Query: 208  RHAEVVASIKAREDEARLLV 227
             H + V  ++A     RL++
Sbjct: 1827 THTDAVNLLRAASKTVRLVI 1846


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 58/218 (26%), Positives = 108/218 (49%), Gaps = 30/218 (13%)

Query: 13  RLVRGEQGYGFHLHGEK----GRRGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGE 67
           +L +G +G GF +        G    +++ + P G+  +   L+AGDRL+EVNGV++ G+
Sbjct: 463 QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522

Query: 68  THHQVVQRIKA--VEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
           +  +VV  +++  +EG   LLV  QE  +    R+L    E +Q  +P   +      D 
Sbjct: 523 SQEEVVSLLRSTKMEGTVSLLVFRQE--DAFHPRELNA--EPSQMQIPK--ETKAEDEDI 576

Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP-----GQYIRSVD 180
             T   + E    +V  PL +          G  G G ++  ++S+      G +++S+ 
Sbjct: 577 VLTPDGTREFLTFEV--PLND---------SGSAGLGVSVKGNRSKENHADLGIFVKSII 625

Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
            G  A++ G LR  D+LI VNG+++ G  + + + +++
Sbjct: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 7/102 (6%)

Query: 154 LRKGPQGYGFNLHSDKSRPGQ----YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLR 208
           L+KG +G GF++ S     G     Y++++ P   A + G L+A DRLIEVNG ++ G  
Sbjct: 464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523

Query: 209 HAEVVASIKA--REDEARLLVVDPETDEHFKRLRVTPTEEHV 248
             EVV+ +++   E    LLV   E   H + L   P++  +
Sbjct: 524 QEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQI 565



 Score = 35.0 bits (79), Expect = 0.095
 Identities = 25/107 (23%), Positives = 52/107 (48%), Gaps = 15/107 (14%)

Query: 17  GEQGYGFHLHGEKGRR-----GQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
           G  G G  + G + +      G F++ +   G+ ++   LR  D+L+ VNG ++ G+T+ 
Sbjct: 597 GSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656

Query: 71  ---QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPP 114
              + ++R  + EG  R ++      + +  R+++   E+   G PP
Sbjct: 657 DAMETLRRSMSTEGNKRGMI------QLIVARRISKCNELKSPGSPP 697


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 59/201 (29%), Positives = 92/201 (45%), Gaps = 15/201 (7%)

Query: 19  QGYGFHLHGEK----GRRGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
           +G GF + G +    G+ G F++ + P GS AE   L+ GD +++VNG+ ++G T  + +
Sbjct: 595 KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654

Query: 74  QRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSS 133
              K +     +L V  +          T T  M++   P  +         +  GS SS
Sbjct: 655 HTFKQIRSGLFVLTVRTKLVSPSLTPCSTPT-HMSRSASPNFNTSGGASAGGSDEGS-SS 712

Query: 134 EAGKKDVSGPLRELRPRLCHLRKGPQGYGFN---LHSDKSRPGQYIRSVDPGSPA-ARSG 189
             G+K   GP   +   +   ++   G G     L  + S PG YI S+ PGS A   S 
Sbjct: 713 SLGRK-TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESN 771

Query: 190 LRAQDRLIEVNGQNVEGLRHA 210
           L   D+++EVN  NV   RHA
Sbjct: 772 LSRGDQILEVNSVNV---RHA 789



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 48/212 (22%), Positives = 88/212 (41%), Gaps = 16/212 (7%)

Query: 73  VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
           V R+++VE    L+V + +     R R L  + +  +  LP   D      ++      +
Sbjct: 509 VHRLESVEEYNELMVRNGDP----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST 564

Query: 133 SEAGKKDVSGPLRELRPRLCHL----RKGPQGYGFNLHSDKS----RPGQYIRSVDPGSP 184
                  V  P R +RP +  +    ++  +G GF++   +     + G +++++ P   
Sbjct: 565 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS 624

Query: 185 AARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
           AA  G L+  D +++VNG  ++GL   E + + K  +  + L V+   T      L    
Sbjct: 625 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK--QIRSGLFVLTVRTKLVSPSLTPCS 682

Query: 244 TEEHVEGPLPSPVTNGTSPAQLNGGSACSSRS 275
           T  H+     SP  N +  A   G    SS S
Sbjct: 683 TPTHMSRS-ASPNFNTSGGASAGGSDEGSSSS 713



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 32/135 (23%), Positives = 57/135 (42%), Gaps = 16/135 (11%)

Query: 14  LVRGEQGYGFHLHGEKGRRGQ----FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGET 68
           L++   G G  + G +G +       + +V+ G  A     L  GD L+ +NG  + G +
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396

Query: 69  HHQVVQRIKAVEGQTRLLVVDQETD-EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
           H + V  +++  G  +L+V  +E   E+L R        +  + LP      E    W  
Sbjct: 397 HEEAVAILRSATGMVQLVVASKENSAEDLLR--------LTSKSLPDLTSSVEDVSSW-- 446

Query: 128 TGSHSSEAGKKDVSG 142
           T +   EA  ++  G
Sbjct: 447 TDNEDQEADGEEDEG 461



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 7/84 (8%)

Query: 11   LC-RLVRGEQGYGFHLHGEK----GRRGQFIRRVEPGSPAEAAAL-RAGDRLVEVNGVNV 64
            LC  +++   G G  L G K    G     I+RV  G  AE A +  AGD ++ +NG  +
Sbjct: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808

Query: 65   EGETHHQVVQRIKAV-EGQTRLLV 87
             G  H      +K+V EG  +LL+
Sbjct: 2809 VGLMHFDAWNIMKSVPEGPVQLLI 2832



 Score = 33.5 bits (75), Expect = 0.28
 Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 14/125 (11%)

Query: 121 PKPDWAHTGSHS----SEAGKKDVSGP---LRELRPRL--CHLRKGPQGYGFNLH----S 167
           PK D   T S+     S+ GK D        RE   R+    L K   G G  +     S
Sbjct: 295 PKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGS 354

Query: 168 DKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
            +S     +  V  G  A R G L   D L+ +NG  + GL H E VA +++     +L+
Sbjct: 355 KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLV 414

Query: 227 VVDPE 231
           V   E
Sbjct: 415 VASKE 419


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 14/216 (6%)

Query: 13  RLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
           +L++G +G GF + G  G +           + +E G+  +   L+ GD+L+ VN V +E
Sbjct: 321 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380

Query: 66  GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
             TH + V  +K       L V    +   +         ++      P  +   P    
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTS---MYMNDGYAPPDITNSSSQPVDNHVSPSSFL 437

Query: 126 AHTGSHSSEAG--KKDVSGPLRELR-PRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPG 182
             T +  +      K V G     R PR   L +G  G GFN+   +   G +I  +  G
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497

Query: 183 SPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
            PA  SG LR  DR+I VN  ++    H +  A++K
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 2/90 (2%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
           PR   L RG  G GF++ G +   G FI  +  G PA+ +  LR GDR++ VN V++   
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523

Query: 68  THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
           +H Q    +K   GQ   +V     +E  R
Sbjct: 524 SHEQAAAALKNA-GQAVTIVAQYRPEEYSR 552



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 67/273 (24%), Positives = 101/273 (36%), Gaps = 70/273 (25%)

Query: 14  LVRGEQGYGFHLHGEKGR------RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEG 66
           L RG  G GF + G             FI ++   G+ A+   LR  D ++ VN V+V  
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
            TH + V+ +K      RL V         +RR                           
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV---------KRR--------------------------- 310

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
                      K VS  + E++     L KGP+G GF++     ++  PG    Y+  + 
Sbjct: 311 -----------KPVSEKIMEIK-----LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354

Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
            G  A + G L+  D+L+ VN   +E + H E V ++K   D   L V  P T  +    
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP-TSMYMNDG 413

Query: 240 RVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACS 272
              P    +      PV N  SP+   G +  S
Sbjct: 414 YAPP---DITNSSSQPVDNHVSPSSFLGQTPAS 443


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 14/216 (6%)

Query: 13  RLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
           +L++G +G GF + G  G +           + +E G+  +   L+ GD+L+ VN V +E
Sbjct: 321 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380

Query: 66  GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
             TH + V  +K       L V    +   +         ++      P  +   P    
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTS---MYMNDGYAPPDITNSSSQPVDNHVSPSSFL 437

Query: 126 AHTGSHSSEAG--KKDVSGPLRELR-PRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPG 182
             T +  +      K V G     R PR   L +G  G GFN+   +   G +I  +  G
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497

Query: 183 SPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
            PA  SG LR  DR+I VN  ++    H +  A++K
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 2/90 (2%)

Query: 9   PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
           PR   L RG  G GF++ G +   G FI  +  G PA+ +  LR GDR++ VN V++   
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523

Query: 68  THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
           +H Q    +K   GQ   +V     +E  R
Sbjct: 524 SHEQAAAALKNA-GQAVTIVAQYRPEEYSR 552



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 67/273 (24%), Positives = 101/273 (36%), Gaps = 70/273 (25%)

Query: 14  LVRGEQGYGFHLHGEKGR------RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEG 66
           L RG  G GF + G             FI ++   G+ A+   LR  D ++ VN V+V  
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286

Query: 67  ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
            TH + V+ +K      RL V         +RR                           
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV---------KRR--------------------------- 310

Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
                      K VS  + E++     L KGP+G GF++     ++  PG    Y+  + 
Sbjct: 311 -----------KPVSEKIMEIK-----LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354

Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
            G  A + G L+  D+L+ VN   +E + H E V ++K   D   L V  P T  +    
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP-TSMYMNDG 413

Query: 240 RVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACS 272
              P    +      PV N  SP+   G +  S
Sbjct: 414 YAPP---DITNSSSQPVDNHVSPSSFLGQTPAS 443


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 42/263 (15%)

Query: 2    AAPEPLRPRLCRLVRGE-QGYGFHLHGEKGRRG-----QFIRRVEPGSPAEAAA-LRAGD 54
            A P P  P    L R E +G+GF +   K +         I RV  GSPA+    L+ GD
Sbjct: 842  ARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGD 901

Query: 55   RLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPP 114
             +  VNG ++   +H  +VQ IK       L V+ +E          +  +  A +  P 
Sbjct: 902  HISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPM 961

Query: 115  AHDPWEPKPDWAHTGSHSSEAGK--KDVSGPLRELRPRLCHL------------------ 154
                    P     G  S+  G+  KDVS   R       HL                  
Sbjct: 962  GQSQANHIP-----GDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQN 1016

Query: 155  --------RKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNV 204
                     +GP+G+GF+L   K    G +I  +    PA + G +   D+++E+NG+  
Sbjct: 1017 LGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076

Query: 205  EGLRHAEVVASIKAREDEARLLV 227
            +G+ H   +  I+A  ++  LL+
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 75/287 (26%), Positives = 121/287 (42%), Gaps = 42/287 (14%)

Query: 14  LVRGEQGYGFHLHGEKGR-RGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQ 71
           L + E G+GF + G  G  +  +I  + P G+  +   LRA D L+ ++G+ V+G++H Q
Sbjct: 729 LRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQ 788

Query: 72  VVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSH 131
           V+  +        +L+          RR++   E+  +     A         +  T + 
Sbjct: 789 VLDLMTTAARNGHVLLTV--------RRKIFYGEKQPEDDSSQA---------FISTQNG 831

Query: 132 SSEAGKKDVSGPLRELRPRLCHL-RKGPQGYGFNLHSDKSRPG-----QYIRSVDPGSPA 185
           S    + +V        P    L RK  +G+GF + + K++P        I  V  GSPA
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891

Query: 186 ARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPT 244
            R G L+  D +  VNGQ++  L H  +V  IK    +A + V           L V   
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK----DAGVTVT----------LTVIAE 937

Query: 245 EEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWK 291
           EEH  GP     +   SPA  +     S  + +PG D+   +G   K
Sbjct: 938 EEH-HGPPSGTNSARQSPALQHRPMGQSQANHIPG-DRSALEGEIGK 982



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 62/236 (26%), Positives = 99/236 (41%), Gaps = 34/236 (14%)

Query: 1   MAAPEPLRPRLCR--LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVE 58
           MA+    +P L    L++G +G+GF +       GQ ++ +      +   L+ GD + E
Sbjct: 566 MASSGSSQPELVTIPLIKGPKGFGFAIADSP--TGQKVKMILDSQWCQG--LQKGDIIKE 621

Query: 59  VNGVNVEGETHHQVVQRIK--AVEGQTRLLVV-----------DQETDEELRRRQLTCTE 105
           +   NV+  TH QVV+ +K   V     LL++             +TD++     L    
Sbjct: 622 IYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN 681

Query: 106 EMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDV-SGPLRELRPRL-----CHLRKGPQ 159
           E       P   P    P    +GS   +  +  + S  L E +P         LRK   
Sbjct: 682 E-------PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES 734

Query: 160 GYGFN-LHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVV 213
           G+GF  L  D      YI ++ P   A + G LRA D L+ ++G  V+G  H +V+
Sbjct: 735 GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 64/245 (26%), Positives = 98/245 (40%), Gaps = 36/245 (14%)

Query: 4   PEPLRPRLCR--LVRGEQGYGFHLHGEKGRRGQFIRR---VEPGSPAEAAALRAGDRLVE 58
           P  L+  L R  L +   G+GF + G   R  +F++    ++ G  A+   +  GD +V+
Sbjct: 401 PSQLKGVLVRASLKKSTMGFGFTIIGGD-RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVD 459

Query: 59  VNGVNVEGETHHQVVQRIKAVEGQTRL---------LVVDQE--------TDEELRRRQL 101
           +NG  V G TH  VVQ  + V     +         L  D E            +  + L
Sbjct: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSL 519

Query: 102 TCTEE-MAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLREL------RPRL--C 152
           T  E  M  +   P     E      HT +     G  D S     +      +P L   
Sbjct: 520 TKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTI 579

Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEV 212
            L KGP+G+GF +    S  GQ ++ +         GL+  D + E+  QNV+ L H +V
Sbjct: 580 PLIKGPKGFGFAIAD--SPTGQKVKMILDSQWC--QGLQKGDIIKEIYHQNVQNLTHLQV 635

Query: 213 VASIK 217
           V  +K
Sbjct: 636 VEVLK 640



 Score = 37.4 bits (85), Expect = 0.019
 Identities = 38/136 (27%), Positives = 60/136 (44%), Gaps = 22/136 (16%)

Query: 154 LRKGPQGYGFNLHSDKSRPGQY--IRSVDPGSPAARSGLRAQ-DRLIEVNGQNVEGLRHA 210
           L+K   G+GF +     RP ++  +++V    PAA+ G  A  D ++++NG  V G  HA
Sbjct: 413 LKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471

Query: 211 EVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPL-----PSPVTNGTSPAQL 265
           +VV   +         +V      +    R  P  +  E P+      +PV NG S   L
Sbjct: 472 DVVQMFQ---------LVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQS---L 519

Query: 266 NGGSACSSRSDL-PGS 280
             G  C +  D  PG+
Sbjct: 520 TKGETCMNPQDFKPGA 535



 Score = 28.9 bits (63), Expect = 6.8
 Identities = 15/37 (40%), Positives = 21/37 (56%)

Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDP 230
           D L+EVNG  V GL + + +A I+   +  RL  V P
Sbjct: 69  DVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKP 105


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,490,821
Number of Sequences: 37866
Number of extensions: 813210
Number of successful extensions: 2679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2030
Number of HSP's gapped (non-prelim): 564
length of query: 337
length of database: 18,247,518
effective HSP length: 103
effective length of query: 234
effective length of database: 14,347,320
effective search space: 3357272880
effective search space used: 3357272880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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