Search of human proteins with 112821681

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112821681 G protein-regulated inducer of neurite outgrowth 1
[Homo sapiens]
         (1008 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112821681 G protein-regulated inducer of neurite outgrowth 1 ...  2018   0.0  
gi|167736355 mucin 4 isoform a [Homo sapiens]                         125   2e-28
gi|112821688 G protein-regulated inducer of neurite outgrowth 2 ...   112   2e-24
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...   109   1e-23
gi|163965366 nascent polypeptide-associated complex alpha subuni...   109   1e-23
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  105   2e-22
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  105   2e-22
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  105   2e-22
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   105   2e-22
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...   104   5e-22
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...   104   5e-22
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...   100   5e-21
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...   100   5e-21
gi|112821690 G protein-regulated inducer of neurite outgrowth 3 ...   100   7e-21
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    94   5e-19
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    94   5e-19
gi|239747654 PREDICTED: hypothetical protein XP_002348126 [Homo ...    94   8e-19
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      92   3e-18
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              87   1e-16
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       79   3e-14
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    77   6e-14
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    74   7e-13
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    73   1e-12
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    73   1e-12
gi|153070260 myristoylated alanine-rich protein kinase C substra...    73   1e-12
gi|82534351 microtubule-associated protein tau isoform 1 [Homo s...    72   3e-12
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          72   3e-12
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    71   4e-12
gi|112421108 capicua homolog [Homo sapiens]                            71   4e-12
gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]            71   6e-12

>gi|112821681 G protein-regulated inducer of neurite outgrowth 1 [Homo
            sapiens]
          Length = 1008

 Score = 2018 bits (5229), Expect = 0.0
 Identities = 1008/1008 (100%), Positives = 1008/1008 (100%)

Query: 1    MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHT 60
            MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHT
Sbjct: 1    MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHT 60

Query: 61   PDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGT 120
            PDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGT
Sbjct: 61   PDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGT 120

Query: 121  PEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPM 180
            PEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPM
Sbjct: 121  PEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPM 180

Query: 181  FTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRK 240
            FTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRK
Sbjct: 181  FTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRK 240

Query: 241  VDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPM 300
            VDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPM
Sbjct: 241  VDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPM 300

Query: 301  PLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGN 360
            PLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGN
Sbjct: 301  PLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGN 360

Query: 361  VETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVS 420
            VETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVS
Sbjct: 361  VETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVS 420

Query: 421  LGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVN 480
            LGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVN
Sbjct: 421  LGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVN 480

Query: 481  PESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTAS 540
            PESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTAS
Sbjct: 481  PESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTAS 540

Query: 541  GKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEA 600
            GKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEA
Sbjct: 541  GKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEA 600

Query: 601  IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
            IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK
Sbjct: 601  IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660

Query: 661  KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKP 720
            KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKP
Sbjct: 661  KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKP 720

Query: 721  SSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPE 780
            SSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPE
Sbjct: 721  SSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPE 780

Query: 781  AAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAF 840
            AAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAF
Sbjct: 781  AAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAF 840

Query: 841  SFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAA 900
            SFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAA
Sbjct: 841  SFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAA 900

Query: 901  VAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPA 960
            VAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPA
Sbjct: 901  VAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPA 960

Query: 961  ARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE 1008
            ARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE
Sbjct: 961  ARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE 1008


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score =  125 bits (315), Expect = 2e-28
 Identities = 209/905 (23%), Positives = 301/905 (33%), Gaps = 97/905 (10%)

Query: 52   ASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESP------ 105
            A+P P   T   S G    H +P    + +S S G    L   SP+  S   +       
Sbjct: 3310 ATPVPVTSTSSASTG----HTTPLPVTDTSSASTGDTTPLPVTSPSSASTGHTTPLHVTI 3365

Query: 106  --SKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSS----- 158
              S  T +     ++G   A+T G   P+    T   S+    P+ +  +   S+     
Sbjct: 3366 PSSASTGDTSTLPVTGASSAST-GHATPLPVTDTSSVSTGHATPLPVTSLSSVSTGDTTP 3424

Query: 159  ---KQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLG 215
                 A S S G+  P        + TG   P ++     V+ G   P+ V      S G
Sbjct: 3425 LPVTDASSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTG 3484

Query: 216  KVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPV-----SS 270
                L  + T + S  +  P  +  +  VS+    P+         +G   P+     SS
Sbjct: 3485 DTTRLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSS 3544

Query: 271  EKVAPTSAEKVDLVLS---GKRDPGP--------SGKADPMPLESMDSASTGKTEPGLLG 319
                 T+   V    S   G+  P P        SG   P+P+ S  S STG   P  + 
Sbjct: 3545 ASTGDTTRLPVTDTSSASTGQATPLPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVT 3604

Query: 320  KLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDP 379
                 S+G   P+   + +  S G   P  +  A   S G+   +P T   S   G   P
Sbjct: 3605 SPSSASTGHVTPLPVTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDASSASTGDTTP 3664

Query: 380  --------ASSGEGRPVSGHT-------DTTASAKTDLTSLK--NVDPMSSGKVDPVSLG 422
                    AS+G+  P+   +       DTT    TD +S    +  P+       VS G
Sbjct: 3665 LPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTDASSASTGHATPLPVTIPSSVSTG 3724

Query: 423  KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE 482
               P+    P   S G A  + V    + S G   P+     D  SA +R  +   V   
Sbjct: 3725 DTMPLPVTSPSSASTGHATPLPVTGLSSASTGDTTPLPVT--DTSSASTRHATPLPVTDT 3782

Query: 483  SSGKTNPVSSGPG---DPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKA---- 535
            SS  T+  +  P       S G A P        A+ G   PL       V++G A    
Sbjct: 3783 SSASTDDTTRLPVTDVSSASTGHATPLPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLP 3842

Query: 536  ----APTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVD 591
                +  ++G A PL V     VS G A   P     SVS G          P+P     
Sbjct: 3843 VTSRSSASTGHATPLPVTDTSSVSTGHATPLPVTSTSSVSTGHAT-------PLPVTSPS 3895

Query: 592  PVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAP 651
              S G A  +P     S      +P+  T A   ++G A P       +   G       
Sbjct: 3896 SASTGHATPVPVTSTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASRGDTSTLPV 3955

Query: 652  GEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVV 711
             +A +      TP     +   S     PL        S G+A   P     S S G   
Sbjct: 3956 TDASSASTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTT 4015

Query: 712  PLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAA 771
            PL +  T PSS+S         S    + +  S G   P   PV+ST ++S G       
Sbjct: 4016 PLPV--TIPSSAS----SGHTTSLPVTDASSVSTGHGTPL--PVTSTSSASTGDTTPLPV 4067

Query: 772  GAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSP 831
                S     A P P   T    T        A P P     + +   A      S  S 
Sbjct: 4068 TDTSSASTGHATPLPVTDTSSAST------GHATPLPVTSLSSVSTGHATPLAVSSATSA 4121

Query: 832  QDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRS---VATGPMTPQ-----AAAP 883
               +  S    +  P   +P  + D G + +     T S   ++T P T       AA  
Sbjct: 4122 STVSSDSPLKME-TPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPI 4180

Query: 884  PAFPE 888
            P  PE
Sbjct: 4181 PILPE 4185



 Score =  125 bits (313), Expect = 3e-28
 Identities = 186/853 (21%), Positives = 289/853 (33%), Gaps = 76/853 (8%)

Query: 73   SPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPV 132
            S +  G+          S++    T     ++ S  T  A    ++ T  A+T G   P+
Sbjct: 2791 SSASTGQATPLPVTSLSSVSTGDTTPLPVTDTSSASTGHATSLPVTDTSSAST-GHATPL 2849

Query: 133  SSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGS--SRKADPMF--------T 182
                T+  S+   +   L   D  S+    +TS+   D  S  +  A P+         T
Sbjct: 2850 PD--TDTSSASTGHATLLPVTDTSSASIGHATSLPVTDTSSISTGHATPLHVTSPSSAST 2907

Query: 183  GKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVD 242
            G A P  +      + G  +P+ V      S G   PL  + T + S     P  +  + 
Sbjct: 2908 GHATPLPVTDTSSASTGHANPLHVTSPSSASTGHATPLPVTDTSSASTGHATPLPVTSLS 2967

Query: 243  PVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPL 302
             VS+    P+         +G   P+     +  S  +   +         +G   P+P+
Sbjct: 2968 SVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSSASTGQATALPVTSTSSASTGDTTPLPV 3027

Query: 303  ESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVE 362
                SASTG+  P  +  L   S+G   P+   + +  S G   P  +  A  AS G   
Sbjct: 3028 TDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSASTGQAT 3087

Query: 363  TVPATK------EDSRFLGKMDPASSGEGRPVS-GHTDTTASAKTDLTSLKNVDPMSSGK 415
             +P T        D+  L    P+S+  G   S   TDT++++  D TSL   D  S+  
Sbjct: 3088 PLPVTSLSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYT 3147

Query: 416  VDPVSL----------GKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRRED 465
             D  SL          G   P+   +   +S G A  + V  A + S G   P+      
Sbjct: 3148 GDTTSLPVTDTSSSSTGDTTPLLVTETSSVSTGHATPLLVTDASSASTGHATPL--HVTS 3205

Query: 466  PISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKA---EPATGGKGDPL 522
            P SA +  T+   V   SS  T   +  P    S  + G  + +       A+ G+  PL
Sbjct: 3206 PSSASTGDTTPVPVTDTSSVSTGHATPLPVTGLSSASTGDTTRLPVTDISSASTGQATPL 3265

Query: 523  SSEKAGLVASGKAAP--------TASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGK 574
                   V++G   P         ++G A PL V      S G A   P     S S   
Sbjct: 3266 PVTNTSSVSTGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSAS--- 3322

Query: 575  VVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQS 634
                 G T P+P       S G    +P     S      +P+  T     ++G      
Sbjct: 3323 ----TGHTTPLPVTDTSSASTGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLP 3378

Query: 635  GGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKA 694
               A +   G        +  +V     TP     +   S     PL        S G+A
Sbjct: 3379 VTGASSASTGHATPLPVTDTSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQA 3438

Query: 695  DSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEP 754
               P     S S G   PL +      S+          ++ +  G        +    P
Sbjct: 3439 TPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTG--------DTTRLP 3490

Query: 755  VSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEA--SAPPPPREDA 812
            V+ T ++S GQ       A   P    ++   G  T    T A S     + P P  + +
Sbjct: 3491 VTDTSSASTGQ-------ATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTS 3543

Query: 813  GTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVA 872
                G    + V  +          SA + QA P   + PS   +G    L    T SV+
Sbjct: 3544 SASTGDTTRLPVTDT---------SSASTGQATPLPVTIPSSSSSGHTTPLPVTSTSSVS 3594

Query: 873  TGPMTPQAAAPPA 885
            TG +TP     P+
Sbjct: 3595 TGHVTPLHVTSPS 3607



 Score =  122 bits (305), Expect = 2e-27
 Identities = 205/930 (22%), Positives = 302/930 (32%), Gaps = 121/930 (13%)

Query: 47   PSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPS 106
            PS        P    D S  + + H +P    + +S S G    L   S +  S  ++  
Sbjct: 1334 PSSASTGDTTPLPVTDAS-SVSTGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTP 1392

Query: 107  KETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSI 166
                         +P + ++G   P+    T   S+    P+ +      S+  A S  +
Sbjct: 1393 LPVT---------SPSSASTGHATPLLVTDTSSASTGHATPLPVTDASSVSTDHATSLPV 1443

Query: 167  GKEDPGSSRKADPM--------FTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVD 218
                  S+    P+         TG+A   ++     V+ G   P+ V      S G V 
Sbjct: 1444 TIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVT 1503

Query: 219  PLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHP--------VSS 270
            PL  +   + S     P  +  +   S+    P+         +G   P        VS+
Sbjct: 1504 PLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVST 1563

Query: 271  EKVAPTSAEKVDLVLSGKRDPGP--------SGKADPMPLESMDSASTGKTEPGLLGKLI 322
                P          +G   P P         G   P+P+ S  SASTG T P  +    
Sbjct: 1564 GHTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSASTGHTTPLPVTDTS 1623

Query: 323  PGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASS 382
              S+G   P+     +  S G   P  +     AS G+   +P T   S   G   P   
Sbjct: 1624 SASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLPVTSTSSASTGHATPL-- 1681

Query: 383  GEGRPVSGHT-----DTTASAKTDLTSLKN--VDPMSSGKVDPVSLGKMDPMCSGKPELL 435
                PV+G +     DTT    TD++S       P+    +  VS G   P+    P   
Sbjct: 1682 ----PVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSA 1737

Query: 436  SPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPG 495
            S G A  + V  A + S G+  P+     D  S  +   +   V   SS  T+  +  P 
Sbjct: 1738 STGHASPLLVTDASSASTGQATPLPVT--DTSSVSTAHATPLPVTGLSSASTDDTTRLPV 1795

Query: 496  ---DPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKA--------APTASGKAE 544
                  S G A P        A+ G   PL    A   ++G          +  +SG   
Sbjct: 1796 TDVSSASTGQAIPLPVTSPSSASTGDTTPLPVTDASSASTGDTTSLPVTIPSSASSGHTT 1855

Query: 545  PLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP---------GKTVPVPSGKVDPVSL 595
             L V     VS G A +       SVS G     P         G T P+       VS 
Sbjct: 1856 SLPVTDASSVSTGHATSLLVTDASSVSTGDTTPLPVTDTNSASTGDTTPLHVTDASSVST 1915

Query: 596  GKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAG 655
            G A ++P   + S      +P+  T     +SG   P     A +   G   +    +A 
Sbjct: 1916 GHATSLPVTSLSSASTGDTTPLPVTSPSSASSGHTTPLPVTDASSVPTGHATSLPVTDAS 1975

Query: 656  AVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSL 715
            +V     TP         S   A PL       VS G+A   P     S S G   PL +
Sbjct: 1976 SVSTGHATPLPVTDASSVSTGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPV 2035

Query: 716  EKTKPSSSSRQ--LDRKALGS----------ARSPEGARGSEGRVEP----KAEPVSSTE 759
              T  +S+ +   L   +L S            SP  A  S G   P     A  VS+  
Sbjct: 2036 TDTSSASTGQDTPLPVTSLSSVSTGDTTPLPVTSPSSA--STGHATPLLVTDASSVSTGH 2093

Query: 760  ASSLGQKDLEAAG-----------------AERSPCPEAAAPPPGPRTRDNFTKAPSWEA 802
            A+SL   D  +                    + +P P  +   P   +  + T  P  + 
Sbjct: 2094 ATSLLVTDASSVSTGHATALHVTDASSLSTGDTTPLPVTS---PSSASTGDTTPLPVTDT 2150

Query: 803  S------APPPPREDAGTQAGAQACVSVAVSPMSPQDGAG--------GSAFSFQAAPRA 848
            S      A   P  D  + +   A         S   G           SA + QA P  
Sbjct: 2151 SSVSTGHATSLPVTDTSSASTGHATSLPVTDTSSASTGHATPLPVTDTSSASTGQATPLP 2210

Query: 849  PSPPSRRDAGLQVSLGAAETRSVATGPMTP 878
             + PS    G  + L   +T S +TG  TP
Sbjct: 2211 VTSPSSASTGHAIPLLVTDTSSASTGQATP 2240



 Score =  119 bits (298), Expect = 1e-26
 Identities = 194/896 (21%), Positives = 288/896 (32%), Gaps = 102/896 (11%)

Query: 71   HRSPSGAGEGASCSDGPRGSLACPSPTCFSPQES---PSKETLEAHGASISGTPEATTSG 127
            H +     + +S S G    L   SP+  S  ++   P  +T        +  P   TS 
Sbjct: 2109 HATALHVTDASSLSTGDTTPLPVTSPSSASTGDTTPLPVTDTSSVSTGHATSLPVTDTSS 2168

Query: 128  KP--EPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKA 185
                   S   T+  S+   +   L   D  S+    +T +    P S+       TG A
Sbjct: 2169 ASTGHATSLPVTDTSSASTGHATPLPVTDTSSASTGQATPLPVTSPSSAS------TGHA 2222

Query: 186  EPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVS 245
             P ++      + G+  P+ V      S G   PL  +   +VS        +  +  VS
Sbjct: 2223 IPLLVTDTSSASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVS 2282

Query: 246  SDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESM 305
            +    P+         +G   P+     +  S      +         +G   P+P+ S 
Sbjct: 2283 TGDTTPLPVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPVTSP 2342

Query: 306  DSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVP 365
             SASTG   P  +      S+G   P+   + +  S G   P  +  A  AS G+   +P
Sbjct: 2343 SSASTGHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLP 2402

Query: 366  ATKEDSRFLGK--------MDPASSGEGR--PVS-------GHTDTTASAKTDLTSLKNV 408
             T   S   G         +  AS+G+    PV+       GH        T   S  + 
Sbjct: 2403 VTDTSSASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSASTGDT 2462

Query: 409  DPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPIS 468
             P+       VS G   P+       +S G   R+ V    + S G   P+        S
Sbjct: 2463 TPLPGTDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSAS 2522

Query: 469  AG--------------SRKTSSEKVNPESSGKTNPVSSGP---GDPRSLGTAGPPSAVKA 511
             G              +R  +S  V   SS  T   +S P       S G A P      
Sbjct: 2523 TGDTTPLPVTNASSLSTRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTST 2582

Query: 512  EPATGGKGDPLSSEKAGLVASGKAAP--------TASGKAEPLAVGKEDPVSKGKADAGP 563
              A+ G   PL        ++G+A P         ++G   PL V      S G A   P
Sbjct: 2583 SSASTGDTTPLPVTDTYSASTGQATPLPVTDTSSASTGDTTPLPVTDTSSASTGHATPLP 2642

Query: 564  SGQGDSVSIGKV----VSTP-----GKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKG 614
                 SVS G      V++P     G T P+P      VS G A ++P     S+     
Sbjct: 2643 VTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDASSVSTGHATSLPVTDASSVFTGHA 2702

Query: 615  SPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGS 674
            + +  T     +SG   P     A +   G   +    +A +V     TP         S
Sbjct: 2703 TSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTDASSVSTGHATPLPVTDASSVS 2762

Query: 675  CRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSS-------RQL 727
               A PL       VS G     P   T S S G+  PL +      S+           
Sbjct: 2763 TGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTDT 2822

Query: 728  DRKALGSARS---PEGARGSEGRVEPKAE--------------PVSSTEASSLGQKDLEA 770
               + G A S    + +  S G   P  +              PV+ T ++S+G      
Sbjct: 2823 SSASTGHATSLPVTDTSSASTGHATPLPDTDTSSASTGHATLLPVTDTSSASIGH----- 2877

Query: 771  AGAERSPCPEAAAPPPGPRTRDNFTKAPSWEAS-APPPPREDAGTQAGAQACVSVAVSPM 829
              A   P  + ++   G  T  + T   S     A P P  D  + +   A      SP 
Sbjct: 2878 --ATSLPVTDTSSISTGHATPLHVTSPSSASTGHATPLPVTDTSSASTGHANPLHVTSPS 2935

Query: 830  SPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPA 885
            S   G         A P   +  S    G    L      SV+TG  TP     P+
Sbjct: 2936 SASTG--------HATPLPVTDTSSASTGHATPLPVTSLSSVSTGDTTPLPVTSPS 2983



 Score =  118 bits (295), Expect = 3e-26
 Identities = 199/892 (22%), Positives = 296/892 (33%), Gaps = 110/892 (12%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEA 112
            +P P   TP  S G      +P      +S S     SL   SP+  S   + S    + 
Sbjct: 2511 TPLPVTDTPSASTG----DTTPLPVTNASSLSTRHATSLHVTSPSSASTGHATSLPVTDT 2566

Query: 113  HGASIS-GTPEATTS------GKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTS 165
              AS    TP   TS      G   P+    T   S+    P  L   D  S+   D+T 
Sbjct: 2567 SAASTGHATPLPVTSTSSASTGDTTPLPVTDTYSASTGQATP--LPVTDTSSASTGDTTP 2624

Query: 166  IGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKT 225
            +   D  S+       TG A P  +     V+ G   P+ V      S G   PL  +  
Sbjct: 2625 LPVTDTSSAS------TGHATPLPVTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDA 2678

Query: 226  YTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHP--------VSSEKVAPTS 277
             +VS        +     V +     +         SG   P        VS+       
Sbjct: 2679 SSVSTGHATSLPVTDASSVFTGHATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLP 2738

Query: 278  AEKVDLVLSGKRDPGP--------SGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKN 329
                  V +G   P P        +G A P+PL S+ S STG T P  +      S+G+ 
Sbjct: 2739 VTDASSVSTGHATPLPVTDASSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQA 2798

Query: 330  GPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVS 389
             P+   + +  S G   P  +     AS G+  ++P T   S        AS+G   P+ 
Sbjct: 2799 TPLPVTSLSSVSTGDTTPLPVTDTSSASTGHATSLPVTDTSS--------ASTGHATPLP 2850

Query: 390  GHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAG 449
              TDT++++    T L   D  S+      S+G    +       +S G A  + V    
Sbjct: 2851 -DTDTSSASTGHATLLPVTDTSSA------SIGHATSLPVTDTSSISTGHATPLHVTSPS 2903

Query: 450  TVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAV 509
            + S G   P+      P++     TSS      S+G  NP+        S G A P    
Sbjct: 2904 SASTGHATPL------PVT----DTSS-----ASTGHANPLHVTSPSSASTGHATPLPVT 2948

Query: 510  KAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDS 569
                A+ G   PL       V++G   P         + G   P+      +  +GQ  +
Sbjct: 2949 DTSSASTGHATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSSASTGQATA 3008

Query: 570  VSIGKVVS-TPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASG 628
            + +    S + G T P+P       S G+A  +P   + S+     +P+  T     ++G
Sbjct: 3009 LPVTSTSSASTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTG 3068

Query: 629  KAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPL------A 682
             A P     A +   GQ          +V     TP         S   A  L      +
Sbjct: 3069 HATPLLVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSS 3128

Query: 683  SGKGEPVSL----------GKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKAL 732
            +  G+  SL          G   S P   T S S G   PL + +T   S+         
Sbjct: 3129 ASTGDTTSLPVTDTSSAYTGDTTSLPVTDTSSSSTGDTTPLLVTETSSVSTGHATPLLVT 3188

Query: 733  GSARSPEG----------ARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAA 782
             ++ +  G          +  S G   P   PV+ T + S G        A   P    +
Sbjct: 3189 DASSASTGHATPLHVTSPSSASTGDTTP--VPVTDTSSVSTGH-------ATPLPVTGLS 3239

Query: 783  APPPGPRTRDNFTKAPSWE-ASAPPPPREDAGTQAGAQACVSVAVSPMSPQDG------- 834
            +   G  TR   T   S     A P P  +  + +          SP S   G       
Sbjct: 3240 SASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMPLPVTSPSSASTGHATPLPV 3299

Query: 835  -AGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPA 885
             +  SA +  A P   +  S    G    L   +T S +TG  TP     P+
Sbjct: 3300 TSTSSASTGHATPVPVTSTSSASTGHTTPLPVTDTSSASTGDTTPLPVTSPS 3351



 Score =  117 bits (293), Expect = 5e-26
 Identities = 198/840 (23%), Positives = 273/840 (32%), Gaps = 92/840 (10%)

Query: 120  TPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADP 179
            TP   TS  P   SS  T P    D + +            A S S G   P     A  
Sbjct: 1935 TPLPVTS--PSSASSGHTTPLPVTDASSVPTGHATSLPVTDASSVSTGHATPLPVTDASS 1992

Query: 180  MFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLR 239
            + TG A P  +     V+ G+  P+ V      S G   PL  + T + S  ++ P  + 
Sbjct: 1993 VSTGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVT 2052

Query: 240  KVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADP 299
             +  VS+    P+         +G   P+     +  S      +L        +G A  
Sbjct: 2053 SLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATA 2112

Query: 300  MPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVG 359
            + +    S STG T P  +      S+G   P+     +  S G      +     AS G
Sbjct: 2113 LHVTDASSLSTGDTTPLPVTSPSSASTGDTTPLPVTDTSSVSTGHATSLPVTDTSSASTG 2172

Query: 360  NVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPV 419
            +  ++P T   S        AS+G   P+   TDT++++    T L    P S+      
Sbjct: 2173 HATSLPVTDTSS--------ASTGHATPLP-VTDTSSASTGQATPLPVTSPSSA------ 2217

Query: 420  SLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAG-SRKTSSEK 478
            S G   P+        S GQA  + V    + S G   P+       +S G +       
Sbjct: 2218 STGHAIPLLVTDTSSASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTS 2277

Query: 479  VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAP- 537
            ++  S+G T P+        S G A P     A  A+ G   PL        ++G   P 
Sbjct: 2278 LSSVSTGDTTPLPVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPL 2337

Query: 538  -------TASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP---------GK 581
                    ++G A PL V     VS G     P     S S G     P         G 
Sbjct: 2338 PVTSPSSASTGHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGD 2397

Query: 582  TVPVPSGKVDPVSLGKAEAIP--------EGKVGSLPLEKGSPVTTTKADPRASGKAQPQ 633
            T P+P       S G A  +P         G    LP+   S  +T  A P         
Sbjct: 2398 TTPLPVTDTSSASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSA 2457

Query: 634  SGGKAETKLPGQE------GAAAP---GEAGAVCLKKETPQASEKVDPGSCRKAEPLASG 684
            S G   T LPG +      G   P    +A +V     T          S     PL   
Sbjct: 2458 STGDT-TPLPGTDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVT 2516

Query: 685  KGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARS---PEGA 741
                 S G  D+ P   T + SL      SL  T PSS+S        G A S    + +
Sbjct: 2517 DTPSASTG--DTTPLPVTNASSLSTRHATSLHVTSPSSAS-------TGHATSLPVTDTS 2567

Query: 742  RGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWE 801
              S G   P   PV+ST ++S G           S     A P P   T    T      
Sbjct: 2568 AASTGHATPL--PVTSTSSASTGDTTPLPVTDTYSASTGQATPLPVTDTSSAST------ 2619

Query: 802  ASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQV 861
                P P  D  + +   A      +  S   G         A P   + PS    G   
Sbjct: 2620 GDTTPLPVTDTSSASTGHATPLPVTNTSSVSTG--------HATPLHVTSPSSASTGHTT 2671

Query: 862  SLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAE-------PVRDVS 914
             L   +  SV+TG     A + P      V  G A +  V  P  A        PV D S
Sbjct: 2672 PLPVTDASSVSTG----HATSLPVTDASSVFTGHATSLPVTIPSSASSGHTTPLPVTDAS 2727



 Score =  112 bits (279), Expect = 2e-24
 Identities = 197/892 (22%), Positives = 290/892 (32%), Gaps = 86/892 (9%)

Query: 60   TPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISG 119
            +PD +  M   H++ S    G + +  P  S    S T  +   +PS     A G + SG
Sbjct: 763  SPDTAAAMTHTHQAESTEASGQTQTSEPASS---GSRTTSAGTATPSSSG--ASGTTPSG 817

Query: 120  TPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKED---PGSSRK 176
            +   +TSG+    SS    P           E +   +S  A   S G      PG+   
Sbjct: 818  SEGISTSGETTRFSS---NPSRDSHTTQSTTELLSASASHGAIPVSTGMASSIVPGTFHP 874

Query: 177  ADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPG 236
                 +    P   G+  P +P      T     +    +      S T +++ +  D  
Sbjct: 875  TLSEASTAGRPT--GQSSPTSPSASPQETAAISRMAQTQRTRTSRGSDTISLASQATDTF 932

Query: 237  SLRKVDPVSSDKVDPVFPRKE----EPRYSGKEHPVSS-EKVAPTSAEKVDLVLSGKRDP 291
            S     P S        P+ E     P  SGK    +      P          +G   P
Sbjct: 933  STVPPTPPSITSTGLTSPQTETHTLSPSGSGKTFTTALISNATPLPVTYASSASTGHTTP 992

Query: 292  --------GPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLG 343
                      +G A P+P+ S  S STG T P  +      S+G   P+   + +  S G
Sbjct: 993  LHVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDTSSESTGHVTPLPVTSFSSASTG 1052

Query: 344  RLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLT 403
               P  +     AS G+V  +P T         +  AS+G+  P+   TDT++++    T
Sbjct: 1053 DSTPLPVTDTSSASTGHVTPLPVT--------SLSSASTGDTTPLP-VTDTSSASTGHAT 1103

Query: 404  SLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRR 463
            SL   D  S      VS G   P+        S G A  + V    +VS G   P+    
Sbjct: 1104 SLPVTDTSS------VSTGHTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLHVTD 1157

Query: 464  EDPISAG-SRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPL 522
                S G +       ++  S+G T P+        S G A P        A+ G   PL
Sbjct: 1158 ASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPL 1217

Query: 523  SSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVS-TPGK 581
                A  V++  A           + G   P+      +  +GQ  S+ +    S + G 
Sbjct: 1218 PVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGD 1277

Query: 582  TVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETK 641
            T P+P       S G    +      S      +P+  T     ++G   P       + 
Sbjct: 1278 TTPLPVTSTSSASTGHVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSA 1337

Query: 642  LPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRK 701
              G        +A +V     TP         S  +A PL       VS G     P   
Sbjct: 1338 STGDTTPLPVTDASSVSTGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTS 1397

Query: 702  TESPSLGKVVPLSLEKTKPSS------------SSRQLDRKALGSARSPEGARGSEGRVE 749
              S S G   PL +  T  +S            SS   D         P  A  S G   
Sbjct: 1398 PSSASTGHATPLLVTDTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAA--STGHTT 1455

Query: 750  PKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPR 809
            P   PV+ T ++S GQ       A      + ++   G  T    T   S       P  
Sbjct: 1456 PL--PVTDTSSASTGQ-------ATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLH 1506

Query: 810  EDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETR 869
              + + A       + V+ +S       SA +    P   + PS    G    L   +  
Sbjct: 1507 VTSPSSASTGHATPLPVTSLS-------SASTGDTMPLPVTSPSSASTGDTTPLPVTDAS 1559

Query: 870  SVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMT 921
            SV+TG  TP     P+         SA      P     PV D S   KG T
Sbjct: 1560 SVSTGHTTPLPVTSPS---------SASTGHTTP----LPVTDTSSASKGDT 1598



 Score =  111 bits (278), Expect = 3e-24
 Identities = 200/893 (22%), Positives = 295/893 (33%), Gaps = 110/893 (12%)

Query: 52   ASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLE 111
            A+  P   T   S G    H +P    + +S S G   SL     +  S   +      +
Sbjct: 1102 ATSLPVTDTSSVSTG----HTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLHVTD 1157

Query: 112  AHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDP 171
            A  AS   T +AT    P PV+S+ +   S+ D  P+ +            S S G   P
Sbjct: 1158 ASSAS---TGQAT----PLPVTSLSSV--STGDTTPLPVTS--------PSSASTGHATP 1200

Query: 172  GSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPR 231
                      TG A P  +     V+      + V      S G   PL  + T + S  
Sbjct: 1201 LLVTDTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTG 1260

Query: 232  KEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDP 291
            +     +     VS+    P+         +G   P+     +P+SA             
Sbjct: 1261 QATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPL--HVTSPSSAS------------ 1306

Query: 292  GPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLG 351
              +G A P+P+ S+ SASTG T P  +      S+G   P+     +  S G   P  + 
Sbjct: 1307 --TGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLHVT 1364

Query: 352  MADPASVGNVETVPATKEDSRFLGKMDP--------ASSGEGRPVSGHTDTTASAKTDLT 403
             A  AS G    +P T   S   G   P        AS+G   P+   TDT++++    T
Sbjct: 1365 DASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLL-VTDTSSASTGHAT 1423

Query: 404  SLKNVDPMSSGKVDPVSL----------GKMDPMCSGKPELLSPGQAERVSVGKAGTVSP 453
             L   D  S       SL          G   P+        S GQA  + V    +VS 
Sbjct: 1424 PLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVST 1483

Query: 454  GKEDPVSSRREDPISAGSRKTSSEKVNPE--SSGKTNPVSSGPGDPRSLGTAGPPSAVKA 511
            G   P+        S G   T     +P   S+G   P+        S G   P      
Sbjct: 1484 GDTTPLPVTSTSSASTG-HVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSP 1542

Query: 512  EPATGGKGDPLSSEKAGLVASGKAAP--------TASGKAEPLAVGKEDPVSKGKADAGP 563
              A+ G   PL    A  V++G   P         ++G   PL V      SKG     P
Sbjct: 1543 SSASTGDTTPLPVTDASSVSTGHTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLP 1602

Query: 564  SGQGDSVSIGKVVSTP---------GKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKG 614
                 S S G     P         G T P+P      +S G A  +      S      
Sbjct: 1603 VTSPSSASTGHTTPLPVTDTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHA 1662

Query: 615  SPVTTTKADPRASGKAQP-------QSGGKAETKLPGQE-GAAAPGEA--------GAVC 658
            +P+  T     ++G A P        +     T+LP  +  +A+ G+A         +V 
Sbjct: 1663 TPLPVTSTSSASTGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVS 1722

Query: 659  LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT 718
                TP         S   A PL        S G+A   P   T S S     PL +   
Sbjct: 1723 TGDTTPLPVTSPSSASTGHASPLLVTDASSASTGQATPLPVTDTSSVSTAHATPLPVTGL 1782

Query: 719  KPSSSSRQLDRKALGSARSP--EGARGSEGRVEPKAEPVSSTEASSLGQKD----LEAAG 772
              +S+          + R P  + +  S G+  P   PV+S  ++S G        +A+ 
Sbjct: 1783 SSASTD--------DTTRLPVTDVSSASTGQAIPL--PVTSPSSASTGDTTPLPVTDASS 1832

Query: 773  AERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQ 832
            A            P   +  + T  P  +AS+       +     A +  +   +P+   
Sbjct: 1833 ASTGDTTSLPVTIPSSASSGHTTSLPVTDASSVSTGHATSLLVTDASSVSTGDTTPLPVT 1892

Query: 833  DGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPA 885
            D    SA +    P   +  S    G   SL      S +TG  TP     P+
Sbjct: 1893 D--TNSASTGDTTPLHVTDASSVSTGHATSLPVTSLSSASTGDTTPLPVTSPS 1943



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 174/869 (20%), Positives = 276/869 (31%), Gaps = 126/869 (14%)

Query: 95   SPTCFSPQESPSKETLEAHGASISGTPEATTSGKPE------PVSSVKTEPKSSDDRNPM 148
            SP+   P+ S +  T ++ GA  +G P   +S  P        +    T P S   +   
Sbjct: 439  SPSSLPPKISTAFHTQQSEGAETTGRPHERSSFSPGVSQEIFTLHETTTWPSSFSSKGHT 498

Query: 149  FLEKMDFKSSKQADSTSIGKEDPGSSRKAD-PMFTGK-------AEPEILGKGDPVAPGR 200
               + +  S+    +T +   +P +      P    K        EP          P  
Sbjct: 499  TWSQTELPSTSTGAATRLVTGNPSTGTAGTIPRVPSKVSAIGEPGEPTTYSSHSTTLPKT 558

Query: 201  --MDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
                  T   ++ G+ G  + L SS +Y+V+   +   S     P SS  +D    ++  
Sbjct: 559  TGAGAQTQWTQETGTTG--EALLSSPSYSVTQMIKTATS-----PSSSPMLDRHTSQQIT 611

Query: 259  PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPM-PLESMDSASTGKTEPGL 317
               S     + S   +P            +  P  S +     P  + +S +T    P  
Sbjct: 612  TAPSTNHSTIHSTSTSP------------QESPAVSQRGHTQAPQTTQESQTTRSVSPMT 659

Query: 318  LGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKM 377
              K +        P SS T +  S   + P              +  P     + F    
Sbjct: 660  DTKTV------TTPGSSFTASGHSPSEIVP--------------QDAPTISAATTFA--- 696

Query: 378  DPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSP 437
             PA +G+G        TT +  T L +  +    + G     SL K   +      + +P
Sbjct: 697  -PAPTGDGH-------TTQAPTTALQAAPSSHDATLGPSGGTSLSKTGALTLANSVVSTP 748

Query: 438  GQAERVSVGKAGTVSP-------------GKEDPVSSRREDPISAGSRKTSSEKVNPESS 484
            G  E      + + SP               E    ++  +P S+GSR TS+    P SS
Sbjct: 749  GGPEGQWTSASASTSPDTAAAMTHTHQAESTEASGQTQTSEPASSGSRTTSAGTATPSSS 808

Query: 485  GKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAE 544
            G +    SG      + T+G  +   + P+        ++E     AS  A P ++G A 
Sbjct: 809  GASGTTPSG---SEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASHGAIPVSTGMAS 865

Query: 545  PLAVGKEDPVSKGKADAG-PSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPE 603
             +  G   P     + AG P+GQ    S     ++P +T  + S          +     
Sbjct: 866  SIVPGTFHPTLSEASTAGRPTGQSSPTSPS---ASPQETAAI-SRMAQTQRTRTSRGSDT 921

Query: 604  GKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKET 663
              + S   +  S V  T     ++G   PQ+  +  T  P   G           +   T
Sbjct: 922  ISLASQATDTFSTVPPTPPSITSTGLTSPQT--ETHTLSPSGSGKTFT----TALISNAT 975

Query: 664  PQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSS 723
            P         S     PL       VS G A   P     S S G   PL +  T   S+
Sbjct: 976  PLPVTYASSASTGHTTPLHVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDTSSEST 1035

Query: 724  SR--QLDRKALGSARSPEG--------ARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGA 773
                 L   +  SA + +         +  S G V P   PV+S  ++S G         
Sbjct: 1036 GHVTPLPVTSFSSASTGDSTPLPVTDTSSASTGHVTPL--PVTSLSSASTGD-------T 1086

Query: 774  ERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQD 833
               P  + ++   G  T    T   S       P      + A      S+ V+  S   
Sbjct: 1087 TPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLPVTDTSSASTGHATSLPVTDTS--- 1143

Query: 834  GAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPE----- 888
                S  +    P   +  S    G    L      SV+TG  TP     P+        
Sbjct: 1144 ----SVSTGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHAT 1199

Query: 889  -VRVRPGSALAAAVAPPEPAEPVRDVSWD 916
             + V   S+ +   A P P      VS D
Sbjct: 1200 PLLVTDTSSASTGHATPLPVTDASSVSTD 1228


>gi|112821688 G protein-regulated inducer of neurite outgrowth 2 [Homo
            sapiens]
          Length = 458

 Score =  112 bits (279), Expect = 2e-24
 Identities = 130/480 (27%), Positives = 196/480 (40%), Gaps = 75/480 (15%)

Query: 563  PSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKA 622
            P  Q  S  +G+      +     S  V    LG+A   P+      P E+G+P  + K 
Sbjct: 20   PLSQSSSSLLGEGREQRPELRKTASSTVWQAQLGEASTRPQA-----PEEEGNPPESMKP 74

Query: 623  DPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLA 682
               +  KA+P +GG   +   G    +  G +    L+  +  A ++      R  +   
Sbjct: 75   ARASGPKARPSAGGHWWSSTVGN--VSTMGGSDLCRLRAPSAAAMQRSHSDLVRSTQMRG 132

Query: 683  SGKGEPVSLGKA--DSAPSRKTE-----SPSLGKVVPLSLEKTKPSSSSRQLDRKALGSA 735
                   SL  +   S+P  + +     +   G   P  LE+              LG++
Sbjct: 133  HSGARKASLSCSALGSSPVHRAQLQPGGTSGQGGQAPAGLERDLAPEDETSNSAWMLGAS 192

Query: 736  R--------SPEGARGSEGRVEPKA-EPVSSTEASSL-------GQKDLEAAGAERSPCP 779
            +            A  S  + EPKA E +++T   +L       G +++ A G       
Sbjct: 193  QLSVPPLDLGDTTAHSSSAQAEPKAAEQLATTTCHALPPAALLCGMREVRAGGCCH---- 248

Query: 780  EAAAPPPG----PRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP--MSPQD 833
              A P  G    P+   + +++              +G   G   C +    P  + P+ 
Sbjct: 249  --ALPATGILAFPKLVASVSESGLQAQHGVKIHCRLSGGLPGHSHCCAHLWGPAGLVPEP 306

Query: 834  GAGGS-----AFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPE 888
            G+          +   AP   SP S +DAG+Q +  AA  ++VAT P     AA   FPE
Sbjct: 307  GSRTKDVWTMTSANDLAPAEASPLSAQDAGVQAAPVAA-CKAVATSPSLEAPAALHVFPE 365

Query: 889  VRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEE 948
            V +  GS+L       E   PVRDV WD +GMTWEVYGAA+++EVLG+AIQKHLE Q E+
Sbjct: 366  VTL--GSSLE------EVPSPVRDVRWDAEGMTWEVYGAAVDLEVLGVAIQKHLEMQFEQ 417

Query: 949  HGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE 1008
               Q APA   +     GR G +                RA++QS+RRP CC  +G   E
Sbjct: 418  --LQRAPASEDSLSV-EGRRGPL----------------RAVMQSLRRPSCCGCSGAAPE 458


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score =  109 bits (273), Expect = 1e-23
 Identities = 220/996 (22%), Positives = 357/996 (35%), Gaps = 165/996 (16%)

Query: 24   PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASC 83
            P     P  G +G  +  ++       K +  P   +     G ES   +P+G       
Sbjct: 234  PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293

Query: 84   SDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-S 142
            S+      A  +P     + +P K    A           T +GKPE  S   +E  S S
Sbjct: 294  SEKILQVRAASAPA----KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349

Query: 143  DDRNP----MFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198
            ++  P    +   K   K+S+   +++  KE P   RK                  P  P
Sbjct: 350  EEETPAAKALLQAKASGKTSQVGAASAPAKESP---RKG---------------AAPAPP 391

Query: 199  GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
            G+  P   + +     GK +    S +      +E P   +        +     P KE 
Sbjct: 392  GKTGPAVAKAQ----AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKES 446

Query: 259  PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP- 315
            PR      P    K  P +A+    V  GK+  D   S +      E++ + +  + +P 
Sbjct: 447  PRKGAA--PAPPRKTGPAAAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500

Query: 316  GLLGKLIPGSSGKNGPVSSGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRF 373
            G   ++ P S+   GP+  G G   PG +G   P+       A VG  E      EDS  
Sbjct: 501  GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------AQVGKWE------EDSE- 546

Query: 374  LGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCS 429
                  +SS E    S     TA A     SL N+    P SS  K  P   G +     
Sbjct: 547  ------SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600

Query: 430  GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
             +  + +   +E  S       +P      +++ +  +     K   +K N  +S K  P
Sbjct: 601  AEKPMDNSESSEESSDSADSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 490  VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
            V  G   PR  GTA  P                         +G +   A G   P    
Sbjct: 659  VRVGTQAPRKAGTATSP-------------------------AGSSPAVAGGTQRP---- 689

Query: 550  KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
             ED  S  ++D+     G +V++G+  S  GK + V +  V PV      ++ +G    L
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVL 743

Query: 610  PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
            P + G  VT  KA+ +   ++       +E +   +E AA+P +     +K    +   K
Sbjct: 744  PGKTGPTVTQVKAEKQEDSES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAK 791

Query: 670  VDPGSCRKAEPLASGKGEPVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSS 722
             +P + R      S KG   + GK  +A ++ K  SPS  KV P       S    +  +
Sbjct: 792  ANPAAAR----APSAKGTISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPA 845

Query: 723  SSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAER 775
            S   + +    +A++  G     G  E +++  S  EA +L Q         + AA A  
Sbjct: 846  SVPSVGKAVATAAQAQTGPEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 776  SPCP-EAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP----MS 830
               P + AAP P  +T  +  +A   + S       D+  +A A    +  + P    + 
Sbjct: 904  KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 831  PQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAE---------TRSVATGPMTPQAA 881
            P     G A +   A  A +P   R +       ++E         T+ +  G  T    
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 882  APPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKH 941
             P A P  R+ P +++A A +  E +  + D    E        G A +V     A    
Sbjct: 1024 MPTAHP--RIAPKASMAGASSSKESSR-ISDGKKQE--------GPATQVSKKNPASLPL 1072

Query: 942  LERQIEEHGRQGAPAPPPAARAGP--GRSGSVRTAP 975
             +  ++   ++ + A PP AR  P  G   +V T P
Sbjct: 1073 TQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLP 1108



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 90/409 (22%), Positives = 143/409 (34%), Gaps = 79/409 (19%)

Query: 612 EKGSPVTTTKADPRAS-------GKAQPQS---GGKAETKLPGQEGAAAP----GEAGAV 657
           E+ +   T KA PR +       G   P S     KAET+  G+ G + P    G+  A 
Sbjct: 91  EEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVAN 150

Query: 658 CLKKETPQASEKVDPGSCRKAEPLASG---------KGEPVSLGKADSAPSRKTESPSLG 708
            L  ++P+ S +    +   +E    G         K   VS G+ADS            
Sbjct: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS------------ 198

Query: 709 KVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDL 768
                S E T  SS    ++ K             S    + KA  VS+ E+ +      
Sbjct: 199 -----SSEDTSSSSDETDVEGKP------------SVKPAQVKASSVSTKESPARKAAPA 241

Query: 769 EAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQAC-----VS 823
                + +P  +  A PP  R +    ++ S E  +       AGT++  +A      V 
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 824 VAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDA-GLQVSLGA----AETRSVATGPMTP 878
            A +P     G G +          P+PP +  A   Q   G     +E+ S  +     
Sbjct: 302 AASAPAKGTPGKGAT----------PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
           +  A  A  + +    ++   A + P    P +  +    G T    G A+     G   
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKT----GPAVAKAQAGKRE 407

Query: 939 QKHLERQIEEHGRQGAPA-PPPAARAGPGRSGS--VRTAPPDGAAKRPP 984
           +       E    + APA   P+ +A   R+ S   + +P  GAA  PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 110/529 (20%), Positives = 177/529 (33%), Gaps = 93/529 (17%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEA 112
            SPA P  TP Q+    +  ++ +      S S         P+  C +P    +  T+  
Sbjct: 967  SPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT 1026

Query: 113  HGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPG 172
                I+  P+A+ +G     SS K   + SD +             ++  +T + K++P 
Sbjct: 1027 AHPRIA--PKASMAG----ASSSKESSRISDGKK------------QEGPATQVSKKNPA 1068

Query: 173  S------SRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSS--- 223
            S      + K       +A+P       PVA  R  P +     +G+L    P  +S   
Sbjct: 1069 SLPLTQAALKVLAQKASEAQP-------PVA--RTQPSSGVDSAVGTLPATSPQSTSVQA 1119

Query: 224  --KTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRK-EEPRYSGKEHPVSSEKVAPTSAEK 280
                    P+  +     K    S D  D        E    G +   S+  + PT +  
Sbjct: 1120 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRT 1179

Query: 281  VDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPG 340
              LV             +    ES +      ++  L G + PG +  N   S  T    
Sbjct: 1180 ETLV-------------EETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1226

Query: 341  SLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT 400
            S   +  T     DP   G  E  P      +  G + P + G+           AS  T
Sbjct: 1227 SSPSVSSTLAAKDDPD--GKQEAKP-----QQAAGMLSPKTGGK---------EAASGTT 1270

Query: 401  DLTSLKNVDPMSSGKVDPVSLGKMDPMCS-GKPELLSPGQAERVSVGKAGTVSPGKEDPV 459
               S K      + +   ++L      C  G+P  L+  Q +  SV K  T      + +
Sbjct: 1271 PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ-ASVVKVLT------ELL 1323

Query: 460  SSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKG 519
               R+  +   + K SS K       K +      GD  +  T   P + K +    G+G
Sbjct: 1324 EQERKKVVD--TTKESSRKGWESRKRKLS------GDQPAART---PRSKKKKKLGAGEG 1372

Query: 520  DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGD 568
               S      V+  K + T+ GKA+      +    KGK   G  G  D
Sbjct: 1373 GEAS------VSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKD 1415


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  109 bits (272), Expect = 1e-23
 Identities = 239/1002 (23%), Positives = 326/1002 (32%), Gaps = 157/1002 (15%)

Query: 47   PSQQKASPAPPRHTPDQSPGMESRHRSP-----SGAGEGASCSDGPRGSLACPSPTCFSP 101
            P +  A+PA     P Q+P +     SP     + A +G   S  P+G+   P+ T  SP
Sbjct: 896  PKEGPATPA-----PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSP 950

Query: 102  QESPSKETLEAHGASISGTPEA--------TTSGKPEPVSSVKTEPKSSDDR-------N 146
            +  P+  + +      + TP +        +  G P P ++    PK             
Sbjct: 951  KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT 1010

Query: 147  PMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTV 206
            P  +     K S  A     G   P ++    P  +  A P  L KG P  P    P   
Sbjct: 1011 PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATP--LPKGAPTTPAATLPSP- 1067

Query: 207  RKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEH 266
                     K  P   S     +P    P S +      S K  P+ P    P   G   
Sbjct: 1068 ---------KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLA 1118

Query: 267  PVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSS 326
                +    T A        G   P P G A   P  +  S   G   P           
Sbjct: 1119 TPPHKGAPTTPAATPPSPKGGLATPPPKG-APTTPAATPPSPKGGLATP----------P 1167

Query: 327  GKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGR 386
             K  P +     P   G       G+A P+  G   T PA    S   G   P  S +G 
Sbjct: 1168 PKGAPTTPAATPPSPKG-------GLATPSPKG-APTTPAATPPSPKGGLATP--SPKGA 1217

Query: 387  PVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSL--GKMDPMCSGKPELLSPGQAERVS 444
            P +    T  S K  L +       ++    P S   G   P   G P   +P  A   S
Sbjct: 1218 PTT-PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAP---TPPAATPPS 1273

Query: 445  VGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSG-PGDPRSLGTA 503
            +       P K  P  +    P   G   TS  K  P     T P   G PG P   G  
Sbjct: 1274 LKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAP 1333

Query: 504  GPPSAVKAEPATGGKGDPL------SSEKAGLVASGKAAPTASGKAEPLAVG--KEDPVS 555
             PP+     P    KG P       SS+      S K  PT    A P   G     P S
Sbjct: 1334 TPPAVTPPSP----KGTPTLPATTPSSKGGPTTPSSKEGPTPPA-ATPSHKGGPAMTPPS 1388

Query: 556  KGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGK---------------VDPVSLGKAEA 600
              +  A PS +GD  S   +  +P K    P  +               V PVSL KA A
Sbjct: 1389 PKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPA 1448

Query: 601  IPEGKVG-SLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCL 659
                K G + P  KG P       P      +P +  +  T    ++  A P   GA  L
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPP---SPKEPPAPKQVATSSSPKKAPATPAPMGAPTL 1505

Query: 660  KKETPQASEKVDPGSCRKAEPLAS-----GKGEPVSLGKADSAPSRKTESPSLGKVVPLS 714
                P + ++V      + +P+A       K  P +L   ++        PS  K   + 
Sbjct: 1506 PAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIP 1565

Query: 715  LEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAE 774
              K  P++ S +        A SP           P   P  ST   +   K+L    A 
Sbjct: 1566 TPKEAPATPSSK-------EASSP-----------PAVTP--STYKGAPSPKELLIPPAV 1605

Query: 775  RSPCP-EAAAPP---PGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMS 830
             SP P EA  PP   P    +   T AP    ++PP           + A V+  +    
Sbjct: 1606 TSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATV 1665

Query: 831  PQDGAGGSAFSFQAAPR----APSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAA--PP 884
            PQ   G  A     A +    AP+P S         +  A TR    GP T +++A  PP
Sbjct: 1666 PQASKGLPAKKGPTALKEVLVAPAPES-------TPIITAPTRK---GPQTKKSSATSPP 1715

Query: 885  AFPEVRVRPGSALAAAVAPPEPAEPV----------RDVSWDEKGMTWEVYGAAMEVEVL 934
              P+   + GS    +   P P  PV          +D S   KG        A    + 
Sbjct: 1716 ICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKA-STPLT 1774

Query: 935  GMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPP 976
              A +K L +  E      AP+PP +    P     V T PP
Sbjct: 1775 AAAFEKVLPKP-ESASVSAAPSPPVSLPLAP---SPVPTLPP 1812



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 182/734 (24%), Positives = 235/734 (32%), Gaps = 167/734 (22%)

Query: 275  PTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSS 334
            P   +KVD +         +      P E   +++T  ++ G L  L    S     VS 
Sbjct: 745  PPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSK-GTLTYLADSPSPLGVSVSP 803

Query: 335  GTGAPGSLGRLDPTCLGMADPAS-VGNVETVPATKEDSRFL---------GKMDPASSGE 384
             T  P       PT  G A P + +GN+ + P +  ++ FL          K  PA++  
Sbjct: 804  QTKRP-------PTKKGSAGPDTPIGNLSS-PVSPVEASFLPENSLSFQGSKDSPATTHS 855

Query: 385  GRPVSGHTDTTASAKTDLTSLK-NVDPMSSGKVDPVSL-----GKMDPMCSGKPELL--- 435
              P S     T SA T L+     + P  +     V+L     G   P     P L    
Sbjct: 856  PTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTS 915

Query: 436  -SPGQAERVSVGKAGTVSPG-KEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPV-SS 492
             SP +A      K    SP  K  P       P   G   T S K  P     T P    
Sbjct: 916  SSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKG 975

Query: 493  GPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKED 552
            GP  P   G   PP+A    P    KG P             A P+  G   P AV    
Sbjct: 976  GPATPSPKGAPTPPAATPPSP----KGGP-------------ATPSPKGAPTPPAVTPPS 1018

Query: 553  PVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLE 612
            P  KG   A P  +G         STP    P PS K  P +    +  P     +LP  
Sbjct: 1019 P--KGSPAATPFPKG--------ASTPPAATP-PSPKGSPAATPLPKGAPTTPAATLPSP 1067

Query: 613  KGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDP 672
            KG P T     P   G   P     A T    + G A P   GA      TP + +    
Sbjct: 1068 KGGPAT-----PSLKGAPTPP----AATPPSPKGGPATPSPKGAPMPPAATPPSPK---- 1114

Query: 673  GSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKAL 732
                       G   P   G A + P+    SP  G   P    K  P++          
Sbjct: 1115 ----------GGLATPPHKG-APTTPAATPPSPKGGLATPPP--KGAPTTP--------- 1152

Query: 733  GSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRD 792
              A +P   +G      PK  P +                A   P P+     P P+   
Sbjct: 1153 --AATPPSPKGGLATPPPKGAPTTP---------------AATPPSPKGGLATPSPKG-- 1193

Query: 793  NFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPP 852
                AP+  A+ PP P+    T +   A  + A +P SP+ G    +        A +PP
Sbjct: 1194 ----APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1249

Query: 853  SRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRP---GSALAAAVAPPEPAEP 909
            S +        G   T      P TP AA PP+       P   G+   A V PP P   
Sbjct: 1250 SPK--------GGPATPPPKGAP-TPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP--- 1297

Query: 910  VRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSG 969
                    KG      G A                       +GAP PP A    P   G
Sbjct: 1298 --------KG------GPATSPP-------------------KGAPTPPAATPPSP--KG 1322

Query: 970  SVRTAPPDGAAKRP 983
            S  T PP GA   P
Sbjct: 1323 SPGTPPPKGAPTPP 1336



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 203/869 (23%), Positives = 274/869 (31%), Gaps = 138/869 (15%)

Query: 61   PDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGT 120
            P+    + S    P+G   G    DG   + A  +P   SP+E P++++  +  AS  GT
Sbjct: 728  PEIPKSVPSPSLPPAGTPPGTKKVDGISHTSAL-APVASSPKECPTEDSGASATASSKGT 786

Query: 121  PEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPM 180
                 +  P P+  V   P++                                  K  P 
Sbjct: 787  -LTYLADSPSPL-GVSVSPQT----------------------------------KRPPT 810

Query: 181  FTGKAEPE--ILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL 238
              G A P+  I     PV+P  ++   + +  L   G  D   ++ + T    K  P + 
Sbjct: 811  KKGSAGPDTPIGNLSSPVSP--VEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAP-TP 867

Query: 239  RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD 298
              V P+S   V    P KE P  S    P   E  A T A K    LS         +A 
Sbjct: 868  SAVTPLSPKGV--TLPPKETPTPSVVNLPFPKEGPA-TPAPKQAPALSMTSSSPKKARAT 924

Query: 299  PMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVS-SGTGAPGSLGRLDPTCLGMADPAS 357
            P P + + ++ + K  P       P  S K GP + S   AP       P+  G     S
Sbjct: 925  PAP-KGIPASPSPKGAPTPPAATPP--SPKGGPATPSPKWAPTPPAATPPSPKGGPATPS 981

Query: 358  VGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVD 417
                 T PA    S   G   P+  G   P                ++    P  S    
Sbjct: 982  PKGAPTPPAATPPSPKGGPATPSPKGAPTP---------------PAVTPPSPKGSPAAT 1026

Query: 418  PVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSE 477
            P   G   P  +  P   SP        G        K  P +     P   G   T S 
Sbjct: 1027 PFPKGASTPPAATPP---SP-------KGSPAATPLPKGAPTTPAATLPSPKGGPATPSL 1076

Query: 478  KVNPESSGKTNP-VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
            K  P     T P    GP  P   G   PP+A    P  GG   P            K A
Sbjct: 1077 KGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSP-KGGLATP----------PHKGA 1125

Query: 537  PTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSG-------K 589
            PT      P   G       G A   P G           +TP  T P P G       K
Sbjct: 1126 PTTPAATPPSPKG-------GLATPPPKG---------APTTPAATPPSPKGGLATPPPK 1169

Query: 590  VDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPR-ASGKAQPQSGG----KAETKLPG 644
              P +       P+G + + P  KG+P T     P    G A P   G     A T    
Sbjct: 1170 GAPTTPAATPPSPKGGLAT-PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP 1228

Query: 645  QEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTES 704
            + G A P   GA      TP + +        K  P       P   G   + P +   +
Sbjct: 1229 KGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN 1288

Query: 705  PSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPV--SSTEASS 762
            P++  V P S  K  P++S  +        A +P   +GS G   PK  P   + T  S 
Sbjct: 1289 PAV--VTPPS-PKGGPATSPPK--GAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343

Query: 763  LGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACV 822
             G   L A        P   +   GP             A  PP P+      +      
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT 1403

Query: 823  SVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPM--TPQA 880
            S AV P+SP+              +AP+ P  R+     S G     +V    +   P  
Sbjct: 1404 SPAVIPLSPK--------------KAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPAT 1449

Query: 881  AAPPAFPEVRVRPGSALAAAVAPPEPAEP 909
            +AP   P      G     AV PP P EP
Sbjct: 1450 SAPKGGPATPSSKGDPTLPAVTPPSPKEP 1478



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 137/573 (23%), Positives = 193/573 (33%), Gaps = 130/573 (22%)

Query: 426  PMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVS-SRREDPISAGSRKT------SSEK 478
            P+ S  P  ++P  A+  S     T SP  E  VS + +  P+  G+  T      +SE 
Sbjct: 649  PLESADPAGVAPTTAKGTSTYTT-TASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASEN 707

Query: 479  --VNPESSGKTNPVSS---GPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKA-GLVAS 532
              V P       P+++    P  P+S+ +   P A          G P  ++K  G+  +
Sbjct: 708  CPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPA----------GTPPGTKKVDGISHT 757

Query: 533  GKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDP 592
               AP AS         KE P     A A  S +G    +    S  G +V  P  K  P
Sbjct: 758  SALAPVASSP-------KECPTEDSGASATASSKGTLTYLADSPSPLGVSVS-PQTKRPP 809

Query: 593  VSLGKAEAIPEGKVGSLPLEKGSPVTTTKAD--PRASGKAQPQSGGKAETKLPGQEGAAA 650
               G A   P+  +G+L     SPV+  +A   P  S   Q      A T  P       
Sbjct: 810  TKKGSAG--PDTPIGNL----SSPVSPVEASFLPENSLSFQGSKDSPATTHSP-----TP 858

Query: 651  PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
            P   GA      TP A   + P                    K  + P ++T +PS   V
Sbjct: 859  PSPKGA-----PTPSAVTPLSP--------------------KGVTLPPKETPTPS---V 890

Query: 711  VPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEA 770
            V L   K  P++ +                         PK  P  S  +SS  +     
Sbjct: 891  VNLPFPKEGPATPA-------------------------PKQAPALSMTSSSPKK----- 920

Query: 771  AGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMS 830
              A  +P P+     P P+       AP+  A+ PP P+    T +   A    A +P S
Sbjct: 921  --ARATPAPKGIPASPSPKG------APTPPAATPPSPKGGPATPSPKWAPTPPAATPPS 972

Query: 831  PQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVR 890
            P+ G    +      P A +PPS +      S   A T    T P    + A   FP+  
Sbjct: 973  PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPK-- 1030

Query: 891  VRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHG 950
               G++   A  PP P          +   T     A +     G A             
Sbjct: 1031 ---GASTPPAATPPSPKGSPAATPLPKGAPT--TPAATLPSPKGGPATP----------S 1075

Query: 951  RQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRP 983
             +GAP PP A    P   G   T  P GA   P
Sbjct: 1076 LKGAPTPPAATPPSP--KGGPATPSPKGAPMPP 1106



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 108/514 (21%), Positives = 173/514 (33%), Gaps = 100/514 (19%)

Query: 474 TSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPA-------TGGKGDPLSSEK 526
           T  E   P++     P+SS      +LG  GP       PA          +  P  S  
Sbjct: 12  TEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPS 71

Query: 527 AGLVASGKAAP---TASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVS-----T 578
             + ++    P   ++SG A PL    E P         P           +++     T
Sbjct: 72  T-IASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGT 130

Query: 579 PGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLP----LEKGSPVTTTKADPRASGKAQPQS 634
           P  + P+    + P S+ K+ A P   + S P     E GS +T +   P A  + +   
Sbjct: 131 PSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSA--PIAPSEPKTNL 188

Query: 635 GGKAETKLPGQEGAAAPG-----------------EAGAVCLKKETPQ-----ASEKV-- 670
                  +P  +G  +P                  ++G   L + TP      AS +V  
Sbjct: 189 NKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKD 248

Query: 671 -----------DPGSCRKAEPLASGKGEPVSLG-KADSAP----SRKTESPSLGKVVPLS 714
                      +PGS     P++     P +L     S P    S+KT  P+     P+S
Sbjct: 249 TTISSVLISPQNPGSLSLKGPVS----PPAALSLSTQSLPVVTSSQKTAGPNTPPDFPIS 304

Query: 715 LEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPV----SSTEASSLGQKDLEA 770
           L      S    L + + GS +   G  G     +P  + +    SST AS   Q+ +  
Sbjct: 305 L-----GSHLAPLHQSSFGSVQL-LGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIP 358

Query: 771 AGAERS---PCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVS 827
               R+   P   AA P   P    +  K PS  +S    P              S ++S
Sbjct: 359 PLPSRNEVVPATVAAFPVVAP----SVDKGPSTISSITCSP------SGSLNVATSFSLS 408

Query: 828 PMSP--QDGAGGSAFSFQAAPRAP-----SPPSRRDAGLQVSLGAAETRSVATGPMTPQA 880
           P +      +  + + +    + P     + P        ++     T  VAT    P +
Sbjct: 409 PTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMS 468

Query: 881 AAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVS 914
           + P +     + P S  A  +AP  P EP   V+
Sbjct: 469 SGPIS----NIEPTSPAALVMAPVAPKEPSTQVA 498



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 52/212 (24%), Positives = 80/212 (37%), Gaps = 25/212 (11%)

Query: 541 GKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVD---PVS-LG 596
           G+A       E  + + +A+        ++S+   +  PG T+P P        P+S   
Sbjct: 3   GEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAAN 62

Query: 597 KAEAIPE-GKVGSLPLEKGSPVTTTKADPRASGKAQP-QSGGKAETKLPGQEGAAAPGEA 654
           +A   P    + S PLE   P +       +SG A P  +  +A T LP   G   P   
Sbjct: 63  QASPFPSPSTIASTPLEVPFPQS-------SSGTALPLGTAPEAPTFLPNLIG--PPISP 113

Query: 655 GAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESP------SLG 708
            A+ L       + K  P S   + PLA     P S+ K+ + P     SP        G
Sbjct: 114 AALALASPMIAPTLKGTPSS---SAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESG 170

Query: 709 KVVPLSLEKTKPSSSSRQLDRKALGSARSPEG 740
            V+ LS     PS     L++       +P+G
Sbjct: 171 SVITLS-APIAPSEPKTNLNKVPSEVVPNPKG 201


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  105 bits (263), Expect = 2e-22
 Identities = 152/740 (20%), Positives = 262/740 (35%), Gaps = 67/740 (9%)

Query: 87  PRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKT---EPKSSD 143
           PR SL   S T      + +KET      + +   + +T GK +  S+ +T   E  S+ 
Sbjct: 126 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 185

Query: 144 DRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDP 203
           D  P    K+  K + +A++T+ G           P  T   EP      +P +    +P
Sbjct: 186 DLAP--TSKVLAKPTPKAETTTKG-----------PALTTPKEPTPTTPKEPASTTPKEP 232

Query: 204 MTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSG 263
                +   +  K     ++K+   +P++  P + ++  P +  +  P   ++  P  + 
Sbjct: 233 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT-TT 291

Query: 264 KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIP 323
           K  P + ++ APT+ +K          P P+   +P P    +   T   EP    K  P
Sbjct: 292 KSAPTTPKEPAPTTPKK----------PAPTTPKEPAPTTPKEPTPTTPKEPAPTTK-EP 340

Query: 324 GSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT-KEDSRFLGKMDPASS 382
             +    P  +    P      +P      +PA     E  P T KE +    K  P ++
Sbjct: 341 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 400

Query: 383 GEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER 442
            E  P +  +  T   +   T+ K   P +  +  P +  K  P    +P   +P +   
Sbjct: 401 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 460

Query: 443 VSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT 502
            +  K    +P +  P + +   P       T+ +K+ P +  K  P +     P +   
Sbjct: 461 TTTKKPAPTTPKEPAPTTPKETAP-------TTPKKLTPTTPEKLAPTTPEKPAPTTPEE 513

Query: 503 AGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADA 561
             P +  +  P T  +  P + + A      + APT   +  P    +  P + K  A  
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 573

Query: 562 GPSGQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
            P G   +       +TP K  P    P+   +P S    +  P    G+ P     P  
Sbjct: 574 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 633

Query: 619 TTKADPRASGKAQPQSGGKAETKL----PGQEGAAAPGEAGAVCLKKETPQASEKVDPGS 674
           TT  +P     A     G A T L    P      AP E      K  T   S+K  P +
Sbjct: 634 TTPKEP-----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 688

Query: 675 CRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGS 734
            ++  P    +  P +  K   AP+     P      P + E + P+++     ++    
Sbjct: 689 PKETAPTTPKEPAPTTPKK--PAPTTPETPP------PTTSEVSTPTTT-----KEPTTI 735

Query: 735 ARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNF 794
            +SP+     E   E  AEP      +S  +  +       +  PE         T  + 
Sbjct: 736 HKSPD-----ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 790

Query: 795 TKAPSWEASAPPPPREDAGT 814
              P    +AP   +E A T
Sbjct: 791 RTTPETTTAAPKMTKETATT 810



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 119/568 (20%), Positives = 199/568 (35%), Gaps = 40/568 (7%)

Query: 360 NVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT---DLTSLKNVDPMSSGKV 416
           N ET   TKE +         ++ +     G   TT++ +T   + TS K++ P S    
Sbjct: 145 NKETTVETKETT---------TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP--VSSRREDPISAGSRKT 474
            P    K +    G P L +P +    +  +  + +P +  P  + S    P       T
Sbjct: 196 KPTP--KAETTTKG-PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 252

Query: 475 SSEKVNPESSGKTN---PVSSGPGDPRSLGTAGP-PSAVKAEPATGGKGDPLSSEKAGLV 530
            S    P+    T    P  + P +P    T  P P+  K+ P T  +  P + +K    
Sbjct: 253 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 312

Query: 531 ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
              + APT   +  P    +  P +K  A   P     +       +TP +  P P+   
Sbjct: 313 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE--PAPTTPK 370

Query: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAA 650
           +P      E  P       P    S  TTTK     + K+ P +  +       +     
Sbjct: 371 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 430

Query: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
           P E      KK  P   ++  P + ++  P  + K  P +  +      ++T   +  K+
Sbjct: 431 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 490

Query: 711 VPLSLEKTKPSSSSRQL----DRKALGSARSPEGARGSE-GRVEPKAEPVSSTE--ASSL 763
            P + EK  P++  +      +  A  +   P      E     PKA   ++ +  A + 
Sbjct: 491 TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTT 550

Query: 764 GQKDLEAAGAERSP-CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACV 822
            ++       E +P  P+  AP     T     K P+      P P+E A T        
Sbjct: 551 PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST 610

Query: 823 SV-AVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAA 881
           +    +P +P+  A          P+ P+P + ++       G A T      P TP+  
Sbjct: 611 TCDKPAPTTPKGTA-------PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 663

Query: 882 APPAF-PEVRVRPGSALAAAVAPPEPAE 908
           AP    P     P S  +   AP  P E
Sbjct: 664 APKELAPTTTKGPTSTTSDKPAPTTPKE 691



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 144/744 (19%), Positives = 264/744 (35%), Gaps = 88/744 (11%)

Query: 96  PTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDF 155
           PT  +P+E                 P +TT  +P P +++K+ P +  +  P   +    
Sbjct: 216 PTPTTPKE-----------------PASTTPKEPTP-TTIKSAPTTPKEPAPTTTKSAPT 257

Query: 156 KSSKQADSTSIGKEDPGSSRKADPMFTGKAEP-EILGKGDPVAPGRMDPMTVRKEDLGSL 214
              + A +T+   ++P  +   +P  T   EP     K  P  P    P T +K    + 
Sbjct: 258 TPKEPAPTTT---KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 215 GKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVA 274
            +  P    +    +P++  P + ++  P +  +  P  P+K  P    +  P + ++ A
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAP-TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 373

Query: 275 PTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSS 334
           PT+           ++P P+   +P P  +  + +T K       K  P +  +  P ++
Sbjct: 374 PTTT----------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 423

Query: 335 GTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
              AP +            +PA     +  P T ++       +PA +   +P       
Sbjct: 424 KEPAPTT----------PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-----P 468

Query: 395 TASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPG 454
           T   +   T+ K   P +  K+ P +  K+ P    KP   +P +    +  +    +P 
Sbjct: 469 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528

Query: 455 KEDPVSSRREDPISAGSRKTSSEK----VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVK 510
           +  P + +   P +      ++ K      P+    T P  + P  P+  GTA P +  +
Sbjct: 529 EPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK--GTA-PTTLKE 585

Query: 511 AEPATGGKG-----DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADAGPS 564
             P T  K       P ++++       K APT      P    +  P + K  A   P 
Sbjct: 586 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 645

Query: 565 GQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTK 621
           G   +       +TP K  P    P+    P S    +  P     + P     P  TT 
Sbjct: 646 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 705

Query: 622 ADPR-ASGKAQPQSGGKAETKLPGQEGAA---APGEAGAVCLKKETPQASEK--VDPGSC 675
             P   + +  P +  +  T    +E      +P E+      + TP+A E    +PG  
Sbjct: 706 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 765

Query: 676 RKAEPLASGKGEPVSLGK-------ADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD 728
               P A+ K E  +  K         + P   T +P + K    + EKT  S  +    
Sbjct: 766 TTKTPAAT-KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 824

Query: 729 RKALGSARSPEGARGSEGRVEPKAEPVSSTE-----ASSLGQKDLEAAGAERSPCPEAAA 783
           +    + +     + +  +    A  V++T+        + + +  A   +R+   +A  
Sbjct: 825 QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 884

Query: 784 PPPGPRTRDNFTKAPSWEASAPPP 807
           P P        TKAP    S   P
Sbjct: 885 PKP-----QKPTKAPKKPTSTKKP 903



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 119/632 (18%), Positives = 225/632 (35%), Gaps = 59/632 (9%)

Query: 3   TAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGS-LGAGSSAMRDYCPSQQKASPAPPRH-- 59
           T ++PA        ++P  P PT    P   +      +  ++  P+  K++P  P+   
Sbjct: 243 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 302

Query: 60  --TPDQSPGMESRHRSPSGAGEGASCSDG-PRGSLACPSPTCFSPQESPSKETLEAHGAS 116
             TP +      +  +P+   E    +   P  +   P+PT  +P+E P+    +    +
Sbjct: 303 PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--TPKE-PAPTAPKKPAPT 359

Query: 117 ISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRK 176
               P  TT  +P P ++ +  P +  +  P   +     + + A +T+  K  P + ++
Sbjct: 360 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT--KSAPTTPKE 417

Query: 177 ADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPG 236
             P  T +  P    +  P  P +  P T ++    +  +  P  + K    +P++  P 
Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 477

Query: 237 SLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGK 296
           + ++  P +  K+ P  P K  P    K  P + E++APT+ E          +P P+  
Sbjct: 478 TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE----------EPTPTTP 527

Query: 297 ADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPA 356
            +P P     +A     EP               P +    AP +            +PA
Sbjct: 528 EEPAPTTPKAAAPNTPKEP--------------APTTPKEPAPTT----------PKEPA 563

Query: 357 SVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                ET P T + +      +PA +   +P       T + +   T+     P +    
Sbjct: 564 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            P +  +  P    +P   +P      ++ +    +P K  P         + G   T+S
Sbjct: 624 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS 681

Query: 477 EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
           +K  P +  +T P +     P +     P +     P T     P ++++   +      
Sbjct: 682 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 741

Query: 537 PTASGKAEPLAVGKED-------PVSKGKADAGP---SGQGDSVSIGKVVSTPGKTVPVP 586
            T    AEP     E+       P +K  A   P   +   D  +   + +TP  T   P
Sbjct: 742 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 801

Query: 587 SGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
             K+   +    E   E K+ +   +  S  T
Sbjct: 802 --KMTKETATTTEKTTESKITATTTQVTSTTT 831



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 125/679 (18%), Positives = 217/679 (31%), Gaps = 46/679 (6%)

Query: 251 PVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSAST 310
           P+ PR   P  S      S      T+ E  +   + K+      +      E+     T
Sbjct: 123 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 182

Query: 311 GKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT--- 367
              +     K++   + K    + G   P      +PT     +PAS    E  P T   
Sbjct: 183 SAKDLAPTSKVLAKPTPKAETTTKG---PALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 239

Query: 368 -----KEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLG 422
                KE +    K  P +  E  P +       + K    +       ++ K  P +  
Sbjct: 240 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 299

Query: 423 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE 482
           +  P    KP   +P +    +  +    +P  ++P  + +E   +       +    P 
Sbjct: 300 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPAPTAPKKPA 357

Query: 483 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK 542
            +    P  + P +P    T  P      EPA        ++ K     + K+APT   +
Sbjct: 358 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417

Query: 543 AEPLAVGKEDPVS-KGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGK-AEA 600
             P    +  P + K  A   P     +       +TP +  P  + K  P +  + A  
Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 477

Query: 601 IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
            P+    + P +K +P T  K  P    K  P +  +     P +     P E      K
Sbjct: 478 TPKETAPTTP-KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 536

Query: 661 KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPS--RKTESPSLGKVVPLSLEKT 718
              P   +  +P      EP  +   EP      ++AP+  + T   +L +  P + +K 
Sbjct: 537 AAAPNTPK--EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 594

Query: 719 KPSSSSRQLDRKALGSA---RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAER 775
            P   +    ++   +     +P   +G+      +  P +  E +    K   A    +
Sbjct: 595 APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLK 653

Query: 776 SPCPEAAAPPPGPRTRDNFTKAPSWEAS---APPPPREDAGTQAGAQACVSVAVSPMSPQ 832
            P P     P         TK P+   S   AP  P+E A T     A       P +P+
Sbjct: 654 EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA-------PTTPK 706

Query: 833 DGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGP--MTPQAAAPPAFPEVR 890
                     + AP  P  P    + +       E  ++   P   TP+ +A P    + 
Sbjct: 707 ----------KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 756

Query: 891 VRPGSALAAAVAPPEPAEP 909
             P          P   +P
Sbjct: 757 NSPKEPGVPTTKTPAATKP 775



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 54/258 (20%), Positives = 86/258 (33%), Gaps = 24/258 (9%)

Query: 660 KKETP------QASEKVDPGSCRKAEP-LASGKGEPVSLGKADSAPSRKTESPSLGKVVP 712
           KK TP      +A   +D G  +   P  ++ +   VS     +        PSL     
Sbjct: 76  KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 135

Query: 713 LSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPK-AEPVSSTEASSLGQKDLEAA 771
            S E +   +    ++ K   +        G E     K  + +  T A  L       A
Sbjct: 136 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 772 GAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSP 831
                P P+A     GP       K P+     P  P+E A T        ++  +P +P
Sbjct: 196 ----KPTPKAETTTKGPALTT--PKEPT-----PTTPKEPASTTPKEPTPTTIKSAPTTP 244

Query: 832 QDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRV 891
           ++ A  +  S    P+ P+P + ++         A T +    P T ++A     P    
Sbjct: 245 KEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA-----PTTPK 299

Query: 892 RPGSALAAAVAPPEPAEP 909
            P        AP  P EP
Sbjct: 300 EPAPTTPKKPAPTTPKEP 317


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  105 bits (263), Expect = 2e-22
 Identities = 152/740 (20%), Positives = 262/740 (35%), Gaps = 67/740 (9%)

Query: 87  PRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKT---EPKSSD 143
           PR SL   S T      + +KET      + +   + +T GK +  S+ +T   E  S+ 
Sbjct: 167 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 226

Query: 144 DRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDP 203
           D  P    K+  K + +A++T+ G           P  T   EP      +P +    +P
Sbjct: 227 DLAP--TSKVLAKPTPKAETTTKG-----------PALTTPKEPTPTTPKEPASTTPKEP 273

Query: 204 MTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSG 263
                +   +  K     ++K+   +P++  P + ++  P +  +  P   ++  P  + 
Sbjct: 274 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT-TT 332

Query: 264 KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIP 323
           K  P + ++ APT+ +K          P P+   +P P    +   T   EP    K  P
Sbjct: 333 KSAPTTPKEPAPTTPKK----------PAPTTPKEPAPTTPKEPTPTTPKEPAPTTK-EP 381

Query: 324 GSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT-KEDSRFLGKMDPASS 382
             +    P  +    P      +P      +PA     E  P T KE +    K  P ++
Sbjct: 382 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 441

Query: 383 GEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER 442
            E  P +  +  T   +   T+ K   P +  +  P +  K  P    +P   +P +   
Sbjct: 442 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 501

Query: 443 VSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT 502
            +  K    +P +  P + +   P       T+ +K+ P +  K  P +     P +   
Sbjct: 502 TTTKKPAPTTPKEPAPTTPKETAP-------TTPKKLTPTTPEKLAPTTPEKPAPTTPEE 554

Query: 503 AGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADA 561
             P +  +  P T  +  P + + A      + APT   +  P    +  P + K  A  
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 614

Query: 562 GPSGQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
            P G   +       +TP K  P    P+   +P S    +  P    G+ P     P  
Sbjct: 615 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 674

Query: 619 TTKADPRASGKAQPQSGGKAETKL----PGQEGAAAPGEAGAVCLKKETPQASEKVDPGS 674
           TT  +P     A     G A T L    P      AP E      K  T   S+K  P +
Sbjct: 675 TTPKEP-----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 729

Query: 675 CRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGS 734
            ++  P    +  P +  K   AP+     P      P + E + P+++     ++    
Sbjct: 730 PKETAPTTPKEPAPTTPKK--PAPTTPETPP------PTTSEVSTPTTT-----KEPTTI 776

Query: 735 ARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNF 794
            +SP+     E   E  AEP      +S  +  +       +  PE         T  + 
Sbjct: 777 HKSPD-----ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 831

Query: 795 TKAPSWEASAPPPPREDAGT 814
              P    +AP   +E A T
Sbjct: 832 RTTPETTTAAPKMTKETATT 851



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 119/568 (20%), Positives = 199/568 (35%), Gaps = 40/568 (7%)

Query: 360 NVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT---DLTSLKNVDPMSSGKV 416
           N ET   TKE +         ++ +     G   TT++ +T   + TS K++ P S    
Sbjct: 186 NKETTVETKETT---------TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP--VSSRREDPISAGSRKT 474
            P    K +    G P L +P +    +  +  + +P +  P  + S    P       T
Sbjct: 237 KPTP--KAETTTKG-PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 293

Query: 475 SSEKVNPESSGKTN---PVSSGPGDPRSLGTAGP-PSAVKAEPATGGKGDPLSSEKAGLV 530
            S    P+    T    P  + P +P    T  P P+  K+ P T  +  P + +K    
Sbjct: 294 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 353

Query: 531 ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
              + APT   +  P    +  P +K  A   P     +       +TP +  P P+   
Sbjct: 354 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE--PAPTTPK 411

Query: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAA 650
           +P      E  P       P    S  TTTK     + K+ P +  +       +     
Sbjct: 412 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 471

Query: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
           P E      KK  P   ++  P + ++  P  + K  P +  +      ++T   +  K+
Sbjct: 472 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 531

Query: 711 VPLSLEKTKPSSSSRQL----DRKALGSARSPEGARGSE-GRVEPKAEPVSSTE--ASSL 763
            P + EK  P++  +      +  A  +   P      E     PKA   ++ +  A + 
Sbjct: 532 TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTT 591

Query: 764 GQKDLEAAGAERSP-CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACV 822
            ++       E +P  P+  AP     T     K P+      P P+E A T        
Sbjct: 592 PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST 651

Query: 823 SV-AVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAA 881
           +    +P +P+  A          P+ P+P + ++       G A T      P TP+  
Sbjct: 652 TCDKPAPTTPKGTA-------PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 704

Query: 882 APPAF-PEVRVRPGSALAAAVAPPEPAE 908
           AP    P     P S  +   AP  P E
Sbjct: 705 APKELAPTTTKGPTSTTSDKPAPTTPKE 732



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 144/744 (19%), Positives = 264/744 (35%), Gaps = 88/744 (11%)

Query: 96  PTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDF 155
           PT  +P+E                 P +TT  +P P +++K+ P +  +  P   +    
Sbjct: 257 PTPTTPKE-----------------PASTTPKEPTP-TTIKSAPTTPKEPAPTTTKSAPT 298

Query: 156 KSSKQADSTSIGKEDPGSSRKADPMFTGKAEP-EILGKGDPVAPGRMDPMTVRKEDLGSL 214
              + A +T+   ++P  +   +P  T   EP     K  P  P    P T +K    + 
Sbjct: 299 TPKEPAPTTT---KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 215 GKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVA 274
            +  P    +    +P++  P + ++  P +  +  P  P+K  P    +  P + ++ A
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAP-TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 414

Query: 275 PTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSS 334
           PT+           ++P P+   +P P  +  + +T K       K  P +  +  P ++
Sbjct: 415 PTTT----------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 464

Query: 335 GTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
              AP +            +PA     +  P T ++       +PA +   +P       
Sbjct: 465 KEPAPTT----------PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-----P 509

Query: 395 TASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPG 454
           T   +   T+ K   P +  K+ P +  K+ P    KP   +P +    +  +    +P 
Sbjct: 510 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569

Query: 455 KEDPVSSRREDPISAGSRKTSSEK----VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVK 510
           +  P + +   P +      ++ K      P+    T P  + P  P+  GTA P +  +
Sbjct: 570 EPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK--GTA-PTTLKE 626

Query: 511 AEPATGGKG-----DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADAGPS 564
             P T  K       P ++++       K APT      P    +  P + K  A   P 
Sbjct: 627 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 686

Query: 565 GQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTK 621
           G   +       +TP K  P    P+    P S    +  P     + P     P  TT 
Sbjct: 687 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 746

Query: 622 ADPR-ASGKAQPQSGGKAETKLPGQEGAA---APGEAGAVCLKKETPQASEK--VDPGSC 675
             P   + +  P +  +  T    +E      +P E+      + TP+A E    +PG  
Sbjct: 747 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 806

Query: 676 RKAEPLASGKGEPVSLGK-------ADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD 728
               P A+ K E  +  K         + P   T +P + K    + EKT  S  +    
Sbjct: 807 TTKTPAAT-KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 865

Query: 729 RKALGSARSPEGARGSEGRVEPKAEPVSSTE-----ASSLGQKDLEAAGAERSPCPEAAA 783
           +    + +     + +  +    A  V++T+        + + +  A   +R+   +A  
Sbjct: 866 QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 925

Query: 784 PPPGPRTRDNFTKAPSWEASAPPP 807
           P P        TKAP    S   P
Sbjct: 926 PKP-----QKPTKAPKKPTSTKKP 944



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 119/632 (18%), Positives = 225/632 (35%), Gaps = 59/632 (9%)

Query: 3   TAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGS-LGAGSSAMRDYCPSQQKASPAPPRH-- 59
           T ++PA        ++P  P PT    P   +      +  ++  P+  K++P  P+   
Sbjct: 284 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 343

Query: 60  --TPDQSPGMESRHRSPSGAGEGASCSDG-PRGSLACPSPTCFSPQESPSKETLEAHGAS 116
             TP +      +  +P+   E    +   P  +   P+PT  +P+E P+    +    +
Sbjct: 344 PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--TPKE-PAPTAPKKPAPT 400

Query: 117 ISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRK 176
               P  TT  +P P ++ +  P +  +  P   +     + + A +T+  K  P + ++
Sbjct: 401 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT--KSAPTTPKE 458

Query: 177 ADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPG 236
             P  T +  P    +  P  P +  P T ++    +  +  P  + K    +P++  P 
Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 518

Query: 237 SLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGK 296
           + ++  P +  K+ P  P K  P    K  P + E++APT+ E          +P P+  
Sbjct: 519 TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE----------EPTPTTP 568

Query: 297 ADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPA 356
            +P P     +A     EP               P +    AP +            +PA
Sbjct: 569 EEPAPTTPKAAAPNTPKEP--------------APTTPKEPAPTT----------PKEPA 604

Query: 357 SVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                ET P T + +      +PA +   +P       T + +   T+     P +    
Sbjct: 605 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            P +  +  P    +P   +P      ++ +    +P K  P         + G   T+S
Sbjct: 665 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS 722

Query: 477 EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
           +K  P +  +T P +     P +     P +     P T     P ++++   +      
Sbjct: 723 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 782

Query: 537 PTASGKAEPLAVGKED-------PVSKGKADAGP---SGQGDSVSIGKVVSTPGKTVPVP 586
            T    AEP     E+       P +K  A   P   +   D  +   + +TP  T   P
Sbjct: 783 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 842

Query: 587 SGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
             K+   +    E   E K+ +   +  S  T
Sbjct: 843 --KMTKETATTTEKTTESKITATTTQVTSTTT 872



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 125/679 (18%), Positives = 217/679 (31%), Gaps = 46/679 (6%)

Query: 251 PVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSAST 310
           P+ PR   P  S      S      T+ E  +   + K+      +      E+     T
Sbjct: 164 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 223

Query: 311 GKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT--- 367
              +     K++   + K    + G   P      +PT     +PAS    E  P T   
Sbjct: 224 SAKDLAPTSKVLAKPTPKAETTTKG---PALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 280

Query: 368 -----KEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLG 422
                KE +    K  P +  E  P +       + K    +       ++ K  P +  
Sbjct: 281 APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 340

Query: 423 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE 482
           +  P    KP   +P +    +  +    +P  ++P  + +E   +       +    P 
Sbjct: 341 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPAPTAPKKPA 398

Query: 483 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK 542
            +    P  + P +P    T  P      EPA        ++ K     + K+APT   +
Sbjct: 399 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458

Query: 543 AEPLAVGKEDPVS-KGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGK-AEA 600
             P    +  P + K  A   P     +       +TP +  P  + K  P +  + A  
Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 518

Query: 601 IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
            P+    + P +K +P T  K  P    K  P +  +     P +     P E      K
Sbjct: 519 TPKETAPTTP-KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 577

Query: 661 KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPS--RKTESPSLGKVVPLSLEKT 718
              P   +  +P      EP  +   EP      ++AP+  + T   +L +  P + +K 
Sbjct: 578 AAAPNTPK--EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 635

Query: 719 KPSSSSRQLDRKALGSA---RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAER 775
            P   +    ++   +     +P   +G+      +  P +  E +    K   A    +
Sbjct: 636 APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLK 694

Query: 776 SPCPEAAAPPPGPRTRDNFTKAPSWEAS---APPPPREDAGTQAGAQACVSVAVSPMSPQ 832
            P P     P         TK P+   S   AP  P+E A T     A       P +P+
Sbjct: 695 EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA-------PTTPK 747

Query: 833 DGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGP--MTPQAAAPPAFPEVR 890
                     + AP  P  P    + +       E  ++   P   TP+ +A P    + 
Sbjct: 748 ----------KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALE 797

Query: 891 VRPGSALAAAVAPPEPAEP 909
             P          P   +P
Sbjct: 798 NSPKEPGVPTTKTPAATKP 816



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 54/258 (20%), Positives = 86/258 (33%), Gaps = 24/258 (9%)

Query: 660 KKETP------QASEKVDPGSCRKAEP-LASGKGEPVSLGKADSAPSRKTESPSLGKVVP 712
           KK TP      +A   +D G  +   P  ++ +   VS     +        PSL     
Sbjct: 117 KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 176

Query: 713 LSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPK-AEPVSSTEASSLGQKDLEAA 771
            S E +   +    ++ K   +        G E     K  + +  T A  L       A
Sbjct: 177 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 772 GAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSP 831
                P P+A     GP       K P+     P  P+E A T        ++  +P +P
Sbjct: 237 ----KPTPKAETTTKGPALTT--PKEPT-----PTTPKEPASTTPKEPTPTTIKSAPTTP 285

Query: 832 QDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRV 891
           ++ A  +  S    P+ P+P + ++         A T +    P T ++A     P    
Sbjct: 286 KEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA-----PTTPK 340

Query: 892 RPGSALAAAVAPPEPAEP 909
            P        AP  P EP
Sbjct: 341 EPAPTTPKKPAPTTPKEP 358


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  105 bits (263), Expect = 2e-22
 Identities = 152/740 (20%), Positives = 262/740 (35%), Gaps = 67/740 (9%)

Query: 87  PRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKT---EPKSSD 143
           PR SL   S T      + +KET      + +   + +T GK +  S+ +T   E  S+ 
Sbjct: 219 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 278

Query: 144 DRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDP 203
           D  P    K+  K + +A++T+ G           P  T   EP      +P +    +P
Sbjct: 279 DLAP--TSKVLAKPTPKAETTTKG-----------PALTTPKEPTPTTPKEPASTTPKEP 325

Query: 204 MTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSG 263
                +   +  K     ++K+   +P++  P + ++  P +  +  P   ++  P  + 
Sbjct: 326 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT-TT 384

Query: 264 KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIP 323
           K  P + ++ APT+ +K          P P+   +P P    +   T   EP    K  P
Sbjct: 385 KSAPTTPKEPAPTTPKK----------PAPTTPKEPAPTTPKEPTPTTPKEPAPTTK-EP 433

Query: 324 GSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT-KEDSRFLGKMDPASS 382
             +    P  +    P      +P      +PA     E  P T KE +    K  P ++
Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 383 GEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER 442
            E  P +  +  T   +   T+ K   P +  +  P +  K  P    +P   +P +   
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553

Query: 443 VSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT 502
            +  K    +P +  P + +   P       T+ +K+ P +  K  P +     P +   
Sbjct: 554 TTTKKPAPTTPKEPAPTTPKETAP-------TTPKKLTPTTPEKLAPTTPEKPAPTTPEE 606

Query: 503 AGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADA 561
             P +  +  P T  +  P + + A      + APT   +  P    +  P + K  A  
Sbjct: 607 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 666

Query: 562 GPSGQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
            P G   +       +TP K  P    P+   +P S    +  P    G+ P     P  
Sbjct: 667 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 726

Query: 619 TTKADPRASGKAQPQSGGKAETKL----PGQEGAAAPGEAGAVCLKKETPQASEKVDPGS 674
           TT  +P     A     G A T L    P      AP E      K  T   S+K  P +
Sbjct: 727 TTPKEP-----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 781

Query: 675 CRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGS 734
            ++  P    +  P +  K   AP+     P      P + E + P+++     ++    
Sbjct: 782 PKETAPTTPKEPAPTTPKK--PAPTTPETPP------PTTSEVSTPTTT-----KEPTTI 828

Query: 735 ARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNF 794
            +SP+     E   E  AEP      +S  +  +       +  PE         T  + 
Sbjct: 829 HKSPD-----ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 883

Query: 795 TKAPSWEASAPPPPREDAGT 814
              P    +AP   +E A T
Sbjct: 884 RTTPETTTAAPKMTKETATT 903



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 119/568 (20%), Positives = 199/568 (35%), Gaps = 40/568 (7%)

Query: 360 NVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT---DLTSLKNVDPMSSGKV 416
           N ET   TKE +         ++ +     G   TT++ +T   + TS K++ P S    
Sbjct: 238 NKETTVETKETT---------TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 288

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP--VSSRREDPISAGSRKT 474
            P    K +    G P L +P +    +  +  + +P +  P  + S    P       T
Sbjct: 289 KPTP--KAETTTKG-PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 345

Query: 475 SSEKVNPESSGKTN---PVSSGPGDPRSLGTAGP-PSAVKAEPATGGKGDPLSSEKAGLV 530
            S    P+    T    P  + P +P    T  P P+  K+ P T  +  P + +K    
Sbjct: 346 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 531 ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
              + APT   +  P    +  P +K  A   P     +       +TP +  P P+   
Sbjct: 406 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE--PAPTTPK 463

Query: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAA 650
           +P      E  P       P    S  TTTK     + K+ P +  +       +     
Sbjct: 464 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 523

Query: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
           P E      KK  P   ++  P + ++  P  + K  P +  +      ++T   +  K+
Sbjct: 524 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 583

Query: 711 VPLSLEKTKPSSSSRQL----DRKALGSARSPEGARGSE-GRVEPKAEPVSSTE--ASSL 763
            P + EK  P++  +      +  A  +   P      E     PKA   ++ +  A + 
Sbjct: 584 TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTT 643

Query: 764 GQKDLEAAGAERSP-CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACV 822
            ++       E +P  P+  AP     T     K P+      P P+E A T        
Sbjct: 644 PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST 703

Query: 823 SV-AVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAA 881
           +    +P +P+  A          P+ P+P + ++       G A T      P TP+  
Sbjct: 704 TCDKPAPTTPKGTA-------PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 756

Query: 882 APPAF-PEVRVRPGSALAAAVAPPEPAE 908
           AP    P     P S  +   AP  P E
Sbjct: 757 APKELAPTTTKGPTSTTSDKPAPTTPKE 784



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 144/744 (19%), Positives = 264/744 (35%), Gaps = 88/744 (11%)

Query: 96  PTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDF 155
           PT  +P+E                 P +TT  +P P +++K+ P +  +  P   +    
Sbjct: 309 PTPTTPKE-----------------PASTTPKEPTP-TTIKSAPTTPKEPAPTTTKSAPT 350

Query: 156 KSSKQADSTSIGKEDPGSSRKADPMFTGKAEP-EILGKGDPVAPGRMDPMTVRKEDLGSL 214
              + A +T+   ++P  +   +P  T   EP     K  P  P    P T +K    + 
Sbjct: 351 TPKEPAPTTT---KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 407

Query: 215 GKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVA 274
            +  P    +    +P++  P + ++  P +  +  P  P+K  P    +  P + ++ A
Sbjct: 408 KEPAPTTPKEPTPTTPKEPAP-TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 466

Query: 275 PTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSS 334
           PT+           ++P P+   +P P  +  + +T K       K  P +  +  P ++
Sbjct: 467 PTTT----------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 516

Query: 335 GTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
              AP +            +PA     +  P T ++       +PA +   +P       
Sbjct: 517 KEPAPTT----------PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-----P 561

Query: 395 TASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPG 454
           T   +   T+ K   P +  K+ P +  K+ P    KP   +P +    +  +    +P 
Sbjct: 562 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621

Query: 455 KEDPVSSRREDPISAGSRKTSSEK----VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVK 510
           +  P + +   P +      ++ K      P+    T P  + P  P+  GTA P +  +
Sbjct: 622 EPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK--GTA-PTTLKE 678

Query: 511 AEPATGGKG-----DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADAGPS 564
             P T  K       P ++++       K APT      P    +  P + K  A   P 
Sbjct: 679 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 738

Query: 565 GQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTK 621
           G   +       +TP K  P    P+    P S    +  P     + P     P  TT 
Sbjct: 739 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 798

Query: 622 ADPR-ASGKAQPQSGGKAETKLPGQEGAA---APGEAGAVCLKKETPQASEK--VDPGSC 675
             P   + +  P +  +  T    +E      +P E+      + TP+A E    +PG  
Sbjct: 799 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 858

Query: 676 RKAEPLASGKGEPVSLGK-------ADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD 728
               P A+ K E  +  K         + P   T +P + K    + EKT  S  +    
Sbjct: 859 TTKTPAAT-KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 917

Query: 729 RKALGSARSPEGARGSEGRVEPKAEPVSSTE-----ASSLGQKDLEAAGAERSPCPEAAA 783
           +    + +     + +  +    A  V++T+        + + +  A   +R+   +A  
Sbjct: 918 QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 977

Query: 784 PPPGPRTRDNFTKAPSWEASAPPP 807
           P P        TKAP    S   P
Sbjct: 978 PKP-----QKPTKAPKKPTSTKKP 996



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 119/632 (18%), Positives = 225/632 (35%), Gaps = 59/632 (9%)

Query: 3   TAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGS-LGAGSSAMRDYCPSQQKASPAPPRH-- 59
           T ++PA        ++P  P PT    P   +      +  ++  P+  K++P  P+   
Sbjct: 336 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 395

Query: 60  --TPDQSPGMESRHRSPSGAGEGASCSDG-PRGSLACPSPTCFSPQESPSKETLEAHGAS 116
             TP +      +  +P+   E    +   P  +   P+PT  +P+E P+    +    +
Sbjct: 396 PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--TPKE-PAPTAPKKPAPT 452

Query: 117 ISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRK 176
               P  TT  +P P ++ +  P +  +  P   +     + + A +T+  K  P + ++
Sbjct: 453 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT--KSAPTTPKE 510

Query: 177 ADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPG 236
             P  T +  P    +  P  P +  P T ++    +  +  P  + K    +P++  P 
Sbjct: 511 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 570

Query: 237 SLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGK 296
           + ++  P +  K+ P  P K  P    K  P + E++APT+ E          +P P+  
Sbjct: 571 TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE----------EPTPTTP 620

Query: 297 ADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPA 356
            +P P     +A     EP               P +    AP +            +PA
Sbjct: 621 EEPAPTTPKAAAPNTPKEP--------------APTTPKEPAPTT----------PKEPA 656

Query: 357 SVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                ET P T + +      +PA +   +P       T + +   T+     P +    
Sbjct: 657 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            P +  +  P    +P   +P      ++ +    +P K  P         + G   T+S
Sbjct: 717 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS 774

Query: 477 EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
           +K  P +  +T P +     P +     P +     P T     P ++++   +      
Sbjct: 775 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 834

Query: 537 PTASGKAEPLAVGKED-------PVSKGKADAGP---SGQGDSVSIGKVVSTPGKTVPVP 586
            T    AEP     E+       P +K  A   P   +   D  +   + +TP  T   P
Sbjct: 835 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 894

Query: 587 SGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
             K+   +    E   E K+ +   +  S  T
Sbjct: 895 --KMTKETATTTEKTTESKITATTTQVTSTTT 924



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 159/856 (18%), Positives = 274/856 (32%), Gaps = 82/856 (9%)

Query: 93  CPSPTCF-----SPQESPS-KETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRN 146
           CP    F     +P   PS K+     GAS   T ++TT   P+P +  KT+     +  
Sbjct: 56  CPDYESFCAEVHNPTSPPSSKKAPPPSGAS--QTIKSTTKRSPKPPNKKKTKKVIESEE- 112

Query: 147 PMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTV 206
               E+     ++++ S+S       + RK        A  E+  K              
Sbjct: 113 --ITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKK------------LK 158

Query: 207 RKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSS----DKVD---------PVF 253
            K++  +  K  P         +    D G  +   P +S    +KV          P+ 
Sbjct: 159 VKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN 218

Query: 254 PRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKT 313
           PR   P  S      S      T+ E  +   + K+      +      E+     T   
Sbjct: 219 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 278

Query: 314 EPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT------ 367
           +     K++   + K    + G   P      +PT     +PAS    E  P T      
Sbjct: 279 DLAPTSKVLAKPTPKAETTTKG---PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 335

Query: 368 --KEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMD 425
             KE +    K  P +  E  P +       + K    +       ++ K  P +  +  
Sbjct: 336 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 395

Query: 426 PMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSG 485
           P    KP   +P +    +  +    +P  ++P  + +E   +       +    P  + 
Sbjct: 396 PTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 453

Query: 486 KTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEP 545
              P  + P +P    T  P      EPA        ++ K     + K+APT   +  P
Sbjct: 454 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 546 LAVGKEDPVS-KGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGK-AEAIPE 603
               +  P + K  A   P     +       +TP +  P  + K  P +  + A   P+
Sbjct: 514 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 573

Query: 604 GKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKET 663
               + P +K +P T  K  P    K  P +  +     P +     P E      K   
Sbjct: 574 ETAPTTP-KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 632

Query: 664 PQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPS--RKTESPSLGKVVPLSLEKTKPS 721
           P   +  +P      EP  +   EP      ++AP+  + T   +L +  P + +K  P 
Sbjct: 633 PNTPK--EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPK 690

Query: 722 SSSRQLDRKALGSA---RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPC 778
             +    ++   +     +P   +G+      +  P +  E +    K   A    + P 
Sbjct: 691 ELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPA 749

Query: 779 PEAAAPPPGPRTRDNFTKAPSWEAS---APPPPREDAGTQAGAQACVSVAVSPMSPQDGA 835
           P     P         TK P+   S   AP  P+E A T     A       P +P+   
Sbjct: 750 PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA-------PTTPK--- 799

Query: 836 GGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGP--MTPQAAAPPAFPEVRVRP 893
                  + AP  P  P    + +       E  ++   P   TP+ +A P    +   P
Sbjct: 800 -------KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 852

Query: 894 GSALAAAVAPPEPAEP 909
                     P   +P
Sbjct: 853 KEPGVPTTKTPAATKP 868


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  105 bits (263), Expect = 2e-22
 Identities = 152/740 (20%), Positives = 262/740 (35%), Gaps = 67/740 (9%)

Query: 87  PRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKT---EPKSSD 143
           PR SL   S T      + +KET      + +   + +T GK +  S+ +T   E  S+ 
Sbjct: 260 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 319

Query: 144 DRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDP 203
           D  P    K+  K + +A++T+ G           P  T   EP      +P +    +P
Sbjct: 320 DLAP--TSKVLAKPTPKAETTTKG-----------PALTTPKEPTPTTPKEPASTTPKEP 366

Query: 204 MTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSG 263
                +   +  K     ++K+   +P++  P + ++  P +  +  P   ++  P  + 
Sbjct: 367 TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT-TT 425

Query: 264 KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIP 323
           K  P + ++ APT+ +K          P P+   +P P    +   T   EP    K  P
Sbjct: 426 KSAPTTPKEPAPTTPKK----------PAPTTPKEPAPTTPKEPTPTTPKEPAPTTK-EP 474

Query: 324 GSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT-KEDSRFLGKMDPASS 382
             +    P  +    P      +P      +PA     E  P T KE +    K  P ++
Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 383 GEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER 442
            E  P +  +  T   +   T+ K   P +  +  P +  K  P    +P   +P +   
Sbjct: 535 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594

Query: 443 VSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT 502
            +  K    +P +  P + +   P       T+ +K+ P +  K  P +     P +   
Sbjct: 595 TTTKKPAPTTPKEPAPTTPKETAP-------TTPKKLTPTTPEKLAPTTPEKPAPTTPEE 647

Query: 503 AGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADA 561
             P +  +  P T  +  P + + A      + APT   +  P    +  P + K  A  
Sbjct: 648 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 707

Query: 562 GPSGQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
            P G   +       +TP K  P    P+   +P S    +  P    G+ P     P  
Sbjct: 708 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 767

Query: 619 TTKADPRASGKAQPQSGGKAETKL----PGQEGAAAPGEAGAVCLKKETPQASEKVDPGS 674
           TT  +P     A     G A T L    P      AP E      K  T   S+K  P +
Sbjct: 768 TTPKEP-----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 822

Query: 675 CRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGS 734
            ++  P    +  P +  K   AP+     P      P + E + P+++     ++    
Sbjct: 823 PKETAPTTPKEPAPTTPKK--PAPTTPETPP------PTTSEVSTPTTT-----KEPTTI 869

Query: 735 ARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNF 794
            +SP+     E   E  AEP      +S  +  +       +  PE         T  + 
Sbjct: 870 HKSPD-----ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 924

Query: 795 TKAPSWEASAPPPPREDAGT 814
              P    +AP   +E A T
Sbjct: 925 RTTPETTTAAPKMTKETATT 944



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 119/568 (20%), Positives = 199/568 (35%), Gaps = 40/568 (7%)

Query: 360 NVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT---DLTSLKNVDPMSSGKV 416
           N ET   TKE +         ++ +     G   TT++ +T   + TS K++ P S    
Sbjct: 279 NKETTVETKETT---------TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 329

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP--VSSRREDPISAGSRKT 474
            P    K +    G P L +P +    +  +  + +P +  P  + S    P       T
Sbjct: 330 KPTP--KAETTTKG-PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 386

Query: 475 SSEKVNPESSGKTN---PVSSGPGDPRSLGTAGP-PSAVKAEPATGGKGDPLSSEKAGLV 530
            S    P+    T    P  + P +P    T  P P+  K+ P T  +  P + +K    
Sbjct: 387 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 531 ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
              + APT   +  P    +  P +K  A   P     +       +TP +  P P+   
Sbjct: 447 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE--PAPTTPK 504

Query: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAA 650
           +P      E  P       P    S  TTTK     + K+ P +  +       +     
Sbjct: 505 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 564

Query: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
           P E      KK  P   ++  P + ++  P  + K  P +  +      ++T   +  K+
Sbjct: 565 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 624

Query: 711 VPLSLEKTKPSSSSRQL----DRKALGSARSPEGARGSE-GRVEPKAEPVSSTE--ASSL 763
            P + EK  P++  +      +  A  +   P      E     PKA   ++ +  A + 
Sbjct: 625 TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTT 684

Query: 764 GQKDLEAAGAERSP-CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACV 822
            ++       E +P  P+  AP     T     K P+      P P+E A T        
Sbjct: 685 PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST 744

Query: 823 SV-AVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAA 881
           +    +P +P+  A          P+ P+P + ++       G A T      P TP+  
Sbjct: 745 TCDKPAPTTPKGTA-------PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 797

Query: 882 APPAF-PEVRVRPGSALAAAVAPPEPAE 908
           AP    P     P S  +   AP  P E
Sbjct: 798 APKELAPTTTKGPTSTTSDKPAPTTPKE 825



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 144/744 (19%), Positives = 264/744 (35%), Gaps = 88/744 (11%)

Query: 96   PTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDF 155
            PT  +P+E                 P +TT  +P P +++K+ P +  +  P   +    
Sbjct: 350  PTPTTPKE-----------------PASTTPKEPTP-TTIKSAPTTPKEPAPTTTKSAPT 391

Query: 156  KSSKQADSTSIGKEDPGSSRKADPMFTGKAEP-EILGKGDPVAPGRMDPMTVRKEDLGSL 214
               + A +T+   ++P  +   +P  T   EP     K  P  P    P T +K    + 
Sbjct: 392  TPKEPAPTTT---KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 448

Query: 215  GKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVA 274
             +  P    +    +P++  P + ++  P +  +  P  P+K  P    +  P + ++ A
Sbjct: 449  KEPAPTTPKEPTPTTPKEPAP-TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 507

Query: 275  PTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSS 334
            PT+           ++P P+   +P P  +  + +T K       K  P +  +  P ++
Sbjct: 508  PTTT----------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 557

Query: 335  GTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
               AP +            +PA     +  P T ++       +PA +   +P       
Sbjct: 558  KEPAPTT----------PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-----P 602

Query: 395  TASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPG 454
            T   +   T+ K   P +  K+ P +  K+ P    KP   +P +    +  +    +P 
Sbjct: 603  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662

Query: 455  KEDPVSSRREDPISAGSRKTSSEK----VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVK 510
            +  P + +   P +      ++ K      P+    T P  + P  P+  GTA P +  +
Sbjct: 663  EPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK--GTA-PTTLKE 719

Query: 511  AEPATGGKG-----DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-KGKADAGPS 564
              P T  K       P ++++       K APT      P    +  P + K  A   P 
Sbjct: 720  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 779

Query: 565  GQGDSVSIGKVVSTPGKTVP---VPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTK 621
            G   +       +TP K  P    P+    P S    +  P     + P     P  TT 
Sbjct: 780  GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 839

Query: 622  ADPR-ASGKAQPQSGGKAETKLPGQEGAA---APGEAGAVCLKKETPQASEK--VDPGSC 675
              P   + +  P +  +  T    +E      +P E+      + TP+A E    +PG  
Sbjct: 840  KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 899

Query: 676  RKAEPLASGKGEPVSLGK-------ADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD 728
                P A+ K E  +  K         + P   T +P + K    + EKT  S  +    
Sbjct: 900  TTKTPAAT-KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 958

Query: 729  RKALGSARSPEGARGSEGRVEPKAEPVSSTE-----ASSLGQKDLEAAGAERSPCPEAAA 783
            +    + +     + +  +    A  V++T+        + + +  A   +R+   +A  
Sbjct: 959  QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 1018

Query: 784  PPPGPRTRDNFTKAPSWEASAPPP 807
            P P        TKAP    S   P
Sbjct: 1019 PKP-----QKPTKAPKKPTSTKKP 1037



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 119/632 (18%), Positives = 225/632 (35%), Gaps = 59/632 (9%)

Query: 3   TAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGS-LGAGSSAMRDYCPSQQKASPAPPRH-- 59
           T ++PA        ++P  P PT    P   +      +  ++  P+  K++P  P+   
Sbjct: 377 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 436

Query: 60  --TPDQSPGMESRHRSPSGAGEGASCSDG-PRGSLACPSPTCFSPQESPSKETLEAHGAS 116
             TP +      +  +P+   E    +   P  +   P+PT  +P+E P+    +    +
Sbjct: 437 PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--TPKE-PAPTAPKKPAPT 493

Query: 117 ISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRK 176
               P  TT  +P P ++ +  P +  +  P   +     + + A +T+  K  P + ++
Sbjct: 494 TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT--KSAPTTPKE 551

Query: 177 ADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPG 236
             P  T +  P    +  P  P +  P T ++    +  +  P  + K    +P++  P 
Sbjct: 552 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 611

Query: 237 SLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGK 296
           + ++  P +  K+ P  P K  P    K  P + E++APT+ E          +P P+  
Sbjct: 612 TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE----------EPTPTTP 661

Query: 297 ADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPA 356
            +P P     +A     EP               P +    AP +            +PA
Sbjct: 662 EEPAPTTPKAAAPNTPKEP--------------APTTPKEPAPTT----------PKEPA 697

Query: 357 SVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                ET P T + +      +PA +   +P       T + +   T+     P +    
Sbjct: 698 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 417 DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            P +  +  P    +P   +P      ++ +    +P K  P         + G   T+S
Sbjct: 758 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS 815

Query: 477 EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
           +K  P +  +T P +     P +     P +     P T     P ++++   +      
Sbjct: 816 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 875

Query: 537 PTASGKAEPLAVGKED-------PVSKGKADAGP---SGQGDSVSIGKVVSTPGKTVPVP 586
            T    AEP     E+       P +K  A   P   +   D  +   + +TP  T   P
Sbjct: 876 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 935

Query: 587 SGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
             K+   +    E   E K+ +   +  S  T
Sbjct: 936 --KMTKETATTTEKTTESKITATTTQVTSTTT 965



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 159/856 (18%), Positives = 274/856 (32%), Gaps = 82/856 (9%)

Query: 93  CPSPTCF-----SPQESPS-KETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRN 146
           CP    F     +P   PS K+     GAS   T ++TT   P+P +  KT+     +  
Sbjct: 97  CPDYESFCAEVHNPTSPPSSKKAPPPSGAS--QTIKSTTKRSPKPPNKKKTKKVIESEE- 153

Query: 147 PMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTV 206
               E+     ++++ S+S       + RK        A  E+  K              
Sbjct: 154 --ITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKK------------LK 199

Query: 207 RKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSS----DKVD---------PVF 253
            K++  +  K  P         +    D G  +   P +S    +KV          P+ 
Sbjct: 200 VKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN 259

Query: 254 PRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKT 313
           PR   P  S      S      T+ E  +   + K+      +      E+     T   
Sbjct: 260 PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 319

Query: 314 EPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPAT------ 367
           +     K++   + K    + G   P      +PT     +PAS    E  P T      
Sbjct: 320 DLAPTSKVLAKPTPKAETTTKG---PALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 376

Query: 368 --KEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMD 425
             KE +    K  P +  E  P +       + K    +       ++ K  P +  +  
Sbjct: 377 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 436

Query: 426 PMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSG 485
           P    KP   +P +    +  +    +P  ++P  + +E   +       +    P  + 
Sbjct: 437 PTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 494

Query: 486 KTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEP 545
              P  + P +P    T  P      EPA        ++ K     + K+APT   +  P
Sbjct: 495 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 546 LAVGKEDPVS-KGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGK-AEAIPE 603
               +  P + K  A   P     +       +TP +  P  + K  P +  + A   P+
Sbjct: 555 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 614

Query: 604 GKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKET 663
               + P +K +P T  K  P    K  P +  +     P +     P E      K   
Sbjct: 615 ETAPTTP-KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 673

Query: 664 PQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPS--RKTESPSLGKVVPLSLEKTKPS 721
           P   +  +P      EP  +   EP      ++AP+  + T   +L +  P + +K  P 
Sbjct: 674 PNTPK--EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPK 731

Query: 722 SSSRQLDRKALGSA---RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPC 778
             +    ++   +     +P   +G+      +  P +  E +    K   A    + P 
Sbjct: 732 ELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPA 790

Query: 779 PEAAAPPPGPRTRDNFTKAPSWEAS---APPPPREDAGTQAGAQACVSVAVSPMSPQDGA 835
           P     P         TK P+   S   AP  P+E A T     A       P +P+   
Sbjct: 791 PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA-------PTTPK--- 840

Query: 836 GGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGP--MTPQAAAPPAFPEVRVRP 893
                  + AP  P  P    + +       E  ++   P   TP+ +A P    +   P
Sbjct: 841 -------KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP 893

Query: 894 GSALAAAVAPPEPAEP 909
                     P   +P
Sbjct: 894 KEPGVPTTKTPAATKP 909


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score =  104 bits (259), Expect = 5e-22
 Identities = 204/924 (22%), Positives = 331/924 (35%), Gaps = 154/924 (16%)

Query: 24   PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASC 83
            P     P  G +G  +  ++       K +  P   +     G ES   +P+G       
Sbjct: 234  PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293

Query: 84   SDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-S 142
            S+      A  +P     + +P K    A           T +GKPE  S   +E  S S
Sbjct: 294  SEKILQVRAASAPA----KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349

Query: 143  DDRNP----MFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198
            ++  P    +   K   K+S+   +++  KE P   RK                  P  P
Sbjct: 350  EEETPAAKALLQAKASGKTSQVGAASAPAKESP---RKG---------------AAPAPP 391

Query: 199  GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
            G+  P   + +     GK +    S +      +E P   +        +     P KE 
Sbjct: 392  GKTGPAVAKAQ----AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKES 446

Query: 259  PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP- 315
            PR      P    K  P +A+    V  GK+  D   S +      E++ + +  + +P 
Sbjct: 447  PRKGAA--PAPPRKTGPAAAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500

Query: 316  GLLGKLIPGSSGKNGPVSSGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRF 373
            G   ++ P S+   GP+  G G   PG +G   P+       A VG  E      EDS  
Sbjct: 501  GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------AQVGKWE------EDSE- 546

Query: 374  LGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCS 429
                  +SS E    S     TA A     SL N+    P SS  K  P   G +     
Sbjct: 547  ------SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600

Query: 430  GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
             +  + +   +E  S       +P      +++ +  +     K   +K N  +S K  P
Sbjct: 601  AEKPMDNSESSEESSDSADSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 490  VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
            V  G   PR  GTA  P                         +G +   A G   P    
Sbjct: 659  VRVGTQAPRKAGTATSP-------------------------AGSSPAVAGGTQRP---- 689

Query: 550  KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
             ED  S  ++D+     G +V++G+  S  GK + V +  V PV      ++ +G    L
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVL 743

Query: 610  PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
            P + G  VT  KA+ +   ++       +E +   +E AA+P +     +K    +   K
Sbjct: 744  PGKTGPTVTQVKAEKQEDSES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAK 791

Query: 670  VDPGSCRKAEPLASGKGEPVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSS 722
             +P + R      S KG   + GK  +A ++ K  SPS  KV P       S    +  +
Sbjct: 792  ANPAAAR----APSAKGTISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPA 845

Query: 723  SSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAER 775
            S   + +    +A++  G     G  E +++  S  EA +L Q         + AA A  
Sbjct: 846  SVPSVGKAVATAAQAQTGPEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 776  SPCP-EAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP----MS 830
               P + AAP P  +T  +  +A   + S       D+  +A A    +  + P    + 
Sbjct: 904  KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 831  PQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAE---------TRSVATGPMTPQAA 881
            P     G A +   A  A +P   R +       ++E         T+ +  G  T    
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 882  APPAFPEVRVRPGSALAAAVAPPE 905
             P A P  R+ P +++A A +  E
Sbjct: 1024 MPTAHP--RIAPKASMAGASSSKE 1045



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 215/933 (23%), Positives = 329/933 (35%), Gaps = 196/933 (21%)

Query: 48  SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDG------PRGSLACPSPTCFSP 101
           S+ +   + P       PGM S  ++ S + + +S SD       P    A    +  S 
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVST 230

Query: 102 QESPSKETLEAHGASISGTPE--------ATTSGKPEPVSSVKTEPKSSDDRNPMFLEKM 153
           +ESP+++   A G     TP+        A  + KPE  S    E   S++  P      
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP-----A 285

Query: 154 DFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKG-DPVAPGRMDPMTVRKEDLG 212
             +S  +A    +      +  K  P           GKG  P  PG+     V  +   
Sbjct: 286 GTRSQVKASEKILQVRAASAPAKGTP-----------GKGATPAPPGKAG--AVASQTKA 332

Query: 213 SLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPV----FPRKEEPRYSGKEHPV 268
              + D   SS+  + S  +E P +   +   +S K   V     P KE PR      P 
Sbjct: 333 GKPEEDSESSSEESSDS-EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA--PA 389

Query: 269 SSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK 328
              K  P  A+      +GKR+      +     E  DS      +    GK  P     
Sbjct: 390 PPGKTGPAVAK----AQAGKREEDSQSSS-----EESDSEEEAPAQAKPSGK-APQVRAA 439

Query: 329 NGPVSSGT---GAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEG 385
           + P         AP    +  P     A    VG  E      EDSR        SS E 
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPA----AAQVQVGKQE------EDSR--------SSSE- 480

Query: 386 RPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSV 445
                 +D  A A  +   +K +    S +V P S   M P+  G               
Sbjct: 481 ---ESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKG--------------- 520

Query: 446 GKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGP 505
             AG V PGK  P +   +        ++SSE+ +  S G+  P +  P   +SLG    
Sbjct: 521 --AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV-PTAVAPAQEKSLG---- 573

Query: 506 PSAVKAEPATG-GKGDPLSSEKAGLVASGKAA------PTASGKAEPLAVGKEDPVSKGK 558
            + ++A+P +   KG P   +KAG VA    A        +S ++   A  +E P +   
Sbjct: 574 -NILQAKPTSSPAKGPP---QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 559 ADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
           A A P     ++ I +  + P KT    S KV PV +G                      
Sbjct: 630 AQAKP-----ALKIPQTKACPKKTNTTASAKVAPVRVG---------------------- 662

Query: 619 TTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKA 678
            T+A PR +G A   +G             ++P  AG      E   +SE+ D    +  
Sbjct: 663 -TQA-PRKAGTATSPAG-------------SSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 679 EPLASGKGEPVSLG---KADSAPSRKTESPSLGKVVP---------LSLEKTKPSSSSRQ 726
             +  G+ + V  G   KA S P + +       V+P         +  EK + S SS +
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE 767

Query: 727 LDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-----KDLEAAGAERSPCPEA 781
            +  +  +A SP   + S  + + KA P ++   S+ G      K + AA   +   P  
Sbjct: 768 -ESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826

Query: 782 AAPP-----------PGPRTRDNFTKAPSWEASAPPPPREDAG-----TQAGAQACVSVA 825
             PP            GP +  +  KA +  A A   P ED+G     + +  +A     
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQ 886

Query: 826 VSPMSPQDGAGGSAFSFQAAPR---APSP-----PSRRDAGLQVSLGAAETRSVATG--P 875
           V P         +    + +PR   AP+P     PS   AG Q   G++   S + G  P
Sbjct: 887 VKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 946

Query: 876 MTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAE 908
               +A     P + V P  + A   A P  A+
Sbjct: 947 AAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQ 979



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 90/409 (22%), Positives = 143/409 (34%), Gaps = 79/409 (19%)

Query: 612 EKGSPVTTTKADPRAS-------GKAQPQS---GGKAETKLPGQEGAAAP----GEAGAV 657
           E+ +   T KA PR +       G   P S     KAET+  G+ G + P    G+  A 
Sbjct: 91  EEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVAN 150

Query: 658 CLKKETPQASEKVDPGSCRKAEPLASG---------KGEPVSLGKADSAPSRKTESPSLG 708
            L  ++P+ S +    +   +E    G         K   VS G+ADS            
Sbjct: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS------------ 198

Query: 709 KVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDL 768
                S E T  SS    ++ K             S    + KA  VS+ E+ +      
Sbjct: 199 -----SSEDTSSSSDETDVEGKP------------SVKPAQVKASSVSTKESPARKAAPA 241

Query: 769 EAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQAC-----VS 823
                + +P  +  A PP  R +    ++ S E  +       AGT++  +A      V 
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 824 VAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDA-GLQVSLGA----AETRSVATGPMTP 878
            A +P     G G +          P+PP +  A   Q   G     +E+ S  +     
Sbjct: 302 AASAPAKGTPGKGAT----------PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
           +  A  A  + +    ++   A + P    P +  +    G T    G A+     G   
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKT----GPAVAKAQAGKRE 407

Query: 939 QKHLERQIEEHGRQGAPA-PPPAARAGPGRSGS--VRTAPPDGAAKRPP 984
           +       E    + APA   P+ +A   R+ S   + +P  GAA  PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score =  104 bits (259), Expect = 5e-22
 Identities = 204/924 (22%), Positives = 331/924 (35%), Gaps = 154/924 (16%)

Query: 24   PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASC 83
            P     P  G +G  +  ++       K +  P   +     G ES   +P+G       
Sbjct: 234  PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293

Query: 84   SDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-S 142
            S+      A  +P     + +P K    A           T +GKPE  S   +E  S S
Sbjct: 294  SEKILQVRAASAPA----KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349

Query: 143  DDRNP----MFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198
            ++  P    +   K   K+S+   +++  KE P   RK                  P  P
Sbjct: 350  EEETPAAKALLQAKASGKTSQVGAASAPAKESP---RKG---------------AAPAPP 391

Query: 199  GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
            G+  P   + +     GK +    S +      +E P   +        +     P KE 
Sbjct: 392  GKTGPAVAKAQ----AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKES 446

Query: 259  PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP- 315
            PR      P    K  P +A+    V  GK+  D   S +      E++ + +  + +P 
Sbjct: 447  PRKGAA--PAPPRKTGPAAAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500

Query: 316  GLLGKLIPGSSGKNGPVSSGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRF 373
            G   ++ P S+   GP+  G G   PG +G   P+       A VG  E      EDS  
Sbjct: 501  GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------AQVGKWE------EDSE- 546

Query: 374  LGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCS 429
                  +SS E    S     TA A     SL N+    P SS  K  P   G +     
Sbjct: 547  ------SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600

Query: 430  GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
             +  + +   +E  S       +P      +++ +  +     K   +K N  +S K  P
Sbjct: 601  AEKPMDNSESSEESSDSADSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 490  VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
            V  G   PR  GTA  P                         +G +   A G   P    
Sbjct: 659  VRVGTQAPRKAGTATSP-------------------------AGSSPAVAGGTQRP---- 689

Query: 550  KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
             ED  S  ++D+     G +V++G+  S  GK + V +  V PV      ++ +G    L
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVL 743

Query: 610  PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
            P + G  VT  KA+ +   ++       +E +   +E AA+P +     +K    +   K
Sbjct: 744  PGKTGPTVTQVKAEKQEDSES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAK 791

Query: 670  VDPGSCRKAEPLASGKGEPVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSS 722
             +P + R      S KG   + GK  +A ++ K  SPS  KV P       S    +  +
Sbjct: 792  ANPAAAR----APSAKGTISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPA 845

Query: 723  SSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAER 775
            S   + +    +A++  G     G  E +++  S  EA +L Q         + AA A  
Sbjct: 846  SVPSVGKAVATAAQAQTGPEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 776  SPCP-EAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP----MS 830
               P + AAP P  +T  +  +A   + S       D+  +A A    +  + P    + 
Sbjct: 904  KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 831  PQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAE---------TRSVATGPMTPQAA 881
            P     G A +   A  A +P   R +       ++E         T+ +  G  T    
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 882  APPAFPEVRVRPGSALAAAVAPPE 905
             P A P  R+ P +++A A +  E
Sbjct: 1024 MPTAHP--RIAPKASMAGASSSKE 1045



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 215/933 (23%), Positives = 329/933 (35%), Gaps = 196/933 (21%)

Query: 48  SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDG------PRGSLACPSPTCFSP 101
           S+ +   + P       PGM S  ++ S + + +S SD       P    A    +  S 
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVST 230

Query: 102 QESPSKETLEAHGASISGTPE--------ATTSGKPEPVSSVKTEPKSSDDRNPMFLEKM 153
           +ESP+++   A G     TP+        A  + KPE  S    E   S++  P      
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP-----A 285

Query: 154 DFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKG-DPVAPGRMDPMTVRKEDLG 212
             +S  +A    +      +  K  P           GKG  P  PG+     V  +   
Sbjct: 286 GTRSQVKASEKILQVRAASAPAKGTP-----------GKGATPAPPGKAG--AVASQTKA 332

Query: 213 SLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPV----FPRKEEPRYSGKEHPV 268
              + D   SS+  + S  +E P +   +   +S K   V     P KE PR      P 
Sbjct: 333 GKPEEDSESSSEESSDS-EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA--PA 389

Query: 269 SSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK 328
              K  P  A+      +GKR+      +     E  DS      +    GK  P     
Sbjct: 390 PPGKTGPAVAK----AQAGKREEDSQSSS-----EESDSEEEAPAQAKPSGK-APQVRAA 439

Query: 329 NGPVSSGT---GAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEG 385
           + P         AP    +  P     A    VG  E      EDSR        SS E 
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPA----AAQVQVGKQE------EDSR--------SSSE- 480

Query: 386 RPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSV 445
                 +D  A A  +   +K +    S +V P S   M P+  G               
Sbjct: 481 ---ESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKG--------------- 520

Query: 446 GKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGP 505
             AG V PGK  P +   +        ++SSE+ +  S G+  P +  P   +SLG    
Sbjct: 521 --AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV-PTAVAPAQEKSLG---- 573

Query: 506 PSAVKAEPATG-GKGDPLSSEKAGLVASGKAA------PTASGKAEPLAVGKEDPVSKGK 558
            + ++A+P +   KG P   +KAG VA    A        +S ++   A  +E P +   
Sbjct: 574 -NILQAKPTSSPAKGPP---QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 559 ADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
           A A P     ++ I +  + P KT    S KV PV +G                      
Sbjct: 630 AQAKP-----ALKIPQTKACPKKTNTTASAKVAPVRVG---------------------- 662

Query: 619 TTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKA 678
            T+A PR +G A   +G             ++P  AG      E   +SE+ D    +  
Sbjct: 663 -TQA-PRKAGTATSPAG-------------SSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 679 EPLASGKGEPVSLG---KADSAPSRKTESPSLGKVVP---------LSLEKTKPSSSSRQ 726
             +  G+ + V  G   KA S P + +       V+P         +  EK + S SS +
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE 767

Query: 727 LDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-----KDLEAAGAERSPCPEA 781
            +  +  +A SP   + S  + + KA P ++   S+ G      K + AA   +   P  
Sbjct: 768 -ESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826

Query: 782 AAPP-----------PGPRTRDNFTKAPSWEASAPPPPREDAG-----TQAGAQACVSVA 825
             PP            GP +  +  KA +  A A   P ED+G     + +  +A     
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQ 886

Query: 826 VSPMSPQDGAGGSAFSFQAAPR---APSP-----PSRRDAGLQVSLGAAETRSVATG--P 875
           V P         +    + +PR   AP+P     PS   AG Q   G++   S + G  P
Sbjct: 887 VKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 946

Query: 876 MTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAE 908
               +A     P + V P  + A   A P  A+
Sbjct: 947 AAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQ 979



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 90/409 (22%), Positives = 143/409 (34%), Gaps = 79/409 (19%)

Query: 612 EKGSPVTTTKADPRAS-------GKAQPQS---GGKAETKLPGQEGAAAP----GEAGAV 657
           E+ +   T KA PR +       G   P S     KAET+  G+ G + P    G+  A 
Sbjct: 91  EEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVAN 150

Query: 658 CLKKETPQASEKVDPGSCRKAEPLASG---------KGEPVSLGKADSAPSRKTESPSLG 708
            L  ++P+ S +    +   +E    G         K   VS G+ADS            
Sbjct: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS------------ 198

Query: 709 KVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDL 768
                S E T  SS    ++ K             S    + KA  VS+ E+ +      
Sbjct: 199 -----SSEDTSSSSDETDVEGKP------------SVKPAQVKASSVSTKESPARKAAPA 241

Query: 769 EAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQAC-----VS 823
                + +P  +  A PP  R +    ++ S E  +       AGT++  +A      V 
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 824 VAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDA-GLQVSLGA----AETRSVATGPMTP 878
            A +P     G G +          P+PP +  A   Q   G     +E+ S  +     
Sbjct: 302 AASAPAKGTPGKGAT----------PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
           +  A  A  + +    ++   A + P    P +  +    G T    G A+     G   
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKT----GPAVAKAQAGKRE 407

Query: 939 QKHLERQIEEHGRQGAPA-PPPAARAGPGRSGS--VRTAPPDGAAKRPP 984
           +       E    + APA   P+ +A   R+ S   + +P  GAA  PP
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score =  100 bits (250), Expect = 5e-21
 Identities = 217/978 (22%), Positives = 354/978 (36%), Gaps = 167/978 (17%)

Query: 48   SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSP-----TCFSPQ 102
            S+ +   + P       PGM S  ++ S + + +S SD     +             +P 
Sbjct: 171  SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPA 230

Query: 103  E-SPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-SDDRNP----MFLEKMDFK 156
            + +P K    A           T +GKPE  S   +E  S S++  P    +   K   K
Sbjct: 231  KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK 290

Query: 157  SSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGK 216
            +S+   +++  KE P   RK                  P  PG+  P   + +     GK
Sbjct: 291  TSQVGAASAPAKESP---RKG---------------AAPAPPGKTGPAVAKAQ----AGK 328

Query: 217  VDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPT 276
             +    S +      +E P   +        +     P KE PR      P    K  P 
Sbjct: 329  REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKESPRKGAA--PAPPRKTGPA 385

Query: 277  SAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP-GLLGKLIPGSSGKNGPVS 333
            +A+    V  GK+  D   S +      E++ + +  + +P G   ++ P S+   GP+ 
Sbjct: 386  AAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 441

Query: 334  SGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGH 391
             G G   PG +G   P+       A VG  E      EDS        +SS E    S  
Sbjct: 442  KGAGPVPPGKVGPATPS-------AQVGKWE------EDSE-------SSSEESSDSSDG 481

Query: 392  TDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGK 447
               TA A     SL N+    P SS  K  P   G +      +  + +   +E  S   
Sbjct: 482  EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 541

Query: 448  AGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPS 507
                +P      +++ +  +     K   +K N  +S K  PV  G   PR  GTA  P 
Sbjct: 542  DSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP- 598

Query: 508  AVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQG 567
                                    +G +   A G   P     ED  S  ++D+     G
Sbjct: 599  ------------------------AGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTG 630

Query: 568  DSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRAS 627
             +V++G+  S  GK + V +  V PV      ++ +G    LP + G  VT  KA+ +  
Sbjct: 631  LAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVLPGKTGPTVTQVKAEKQED 684

Query: 628  GKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGE 687
             ++       +E +   +E AA+P +     +K    +   K +P + R      S KG 
Sbjct: 685  SES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAKANPAAAR----APSAKGT 728

Query: 688  PVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSSSSRQLDRKALGSARSPEG 740
              + GK  +A ++ K  SPS  KV P       S    +  +S   + +    +A++  G
Sbjct: 729  ISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 786

Query: 741  ARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAERSPCP-EAAAPPPGPRTRD 792
                 G  E +++  S  EA +L Q         + AA A     P + AAP P  +T  
Sbjct: 787  PEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 844

Query: 793  NFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP----MSPQDGAGGSAFSFQAAPRA 848
            +  +A   + S       D+  +A A    +  + P    + P     G A +   A  A
Sbjct: 845  SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904

Query: 849  PSPPSRRDAGLQVSLGAAE---------TRSVATGPMTPQAAAPPAFPEVRVRPGSALAA 899
             +P   R +       ++E         T+ +  G  T     P A P  R+ P +++A 
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP--RIAPKASMAG 962

Query: 900  AVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPP 959
            A +  E +  + D    E        G A +V     A     +  ++   ++ + A PP
Sbjct: 963  ASSSKESSR-ISDGKKQE--------GPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1013

Query: 960  AARAGP--GRSGSVRTAP 975
             AR  P  G   +V T P
Sbjct: 1014 VARTQPSSGVDSAVGTLP 1031



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 104/517 (20%), Positives = 169/517 (32%), Gaps = 68/517 (13%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEA 112
            SPA P  TP Q+    +  ++ +      S S         P+  C +P    +  T+  
Sbjct: 890  SPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT 949

Query: 113  HGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPG 172
                I+  P+A+ +G     SS K   + SD +             ++  +T + K++P 
Sbjct: 950  AHPRIA--PKASMAG----ASSSKESSRISDGKK------------QEGPATQVSKKNPA 991

Query: 173  SSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRK 232
            S        T  A   +  K     P    P+   +   G    V  L ++   + S + 
Sbjct: 992  SLP-----LTQAALKVLAQKASEAQP----PVARTQPSSGVDSAVGTLPATSPQSTSVQA 1042

Query: 233  EDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPG 292
            +    LRK       +        ++   S      S E        K    L G     
Sbjct: 1043 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSR 1102

Query: 293  PSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGM 352
                 +    ES +      ++  L G + PG +  N   S  T    S   +  T    
Sbjct: 1103 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAK 1162

Query: 353  ADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMS 412
             DP   G  E  P      +  G + P + G+           AS  T   S K      
Sbjct: 1163 DDPD--GKQEAKP-----QQAAGMLSPKTGGK---------EAASGTTPQKSRKPKKGAG 1206

Query: 413  SGKVDPVSLGKMDPMCS-GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGS 471
            + +   ++L      C  G+P  L+  Q +  SV K  T      + +   R+  +   +
Sbjct: 1207 NPQASTLALQSNITQCLLGQPWPLNEAQVQ-ASVVKVLT------ELLEQERKKVVD--T 1257

Query: 472  RKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVA 531
             K SS K       K +      GD  +  T   P + K +    G+G   S      V+
Sbjct: 1258 TKESSRKGWESRKRKLS------GDQPAART---PRSKKKKKLGAGEGGEAS------VS 1302

Query: 532  SGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGD 568
              K + T+ GKA+      +    KGK   G  G  D
Sbjct: 1303 PEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKD 1339


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score =  100 bits (250), Expect = 5e-21
 Identities = 217/978 (22%), Positives = 354/978 (36%), Gaps = 167/978 (17%)

Query: 48   SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSP-----TCFSPQ 102
            S+ +   + P       PGM S  ++ S + + +S SD     +             +P 
Sbjct: 171  SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPA 230

Query: 103  E-SPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-SDDRNP----MFLEKMDFK 156
            + +P K    A           T +GKPE  S   +E  S S++  P    +   K   K
Sbjct: 231  KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGK 290

Query: 157  SSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGK 216
            +S+   +++  KE P   RK                  P  PG+  P   + +     GK
Sbjct: 291  TSQVGAASAPAKESP---RKG---------------AAPAPPGKTGPAVAKAQ----AGK 328

Query: 217  VDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPT 276
             +    S +      +E P   +        +     P KE PR      P    K  P 
Sbjct: 329  REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKESPRKGAA--PAPPRKTGPA 385

Query: 277  SAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP-GLLGKLIPGSSGKNGPVS 333
            +A+    V  GK+  D   S +      E++ + +  + +P G   ++ P S+   GP+ 
Sbjct: 386  AAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 441

Query: 334  SGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGH 391
             G G   PG +G   P+       A VG  E      EDS        +SS E    S  
Sbjct: 442  KGAGPVPPGKVGPATPS-------AQVGKWE------EDSE-------SSSEESSDSSDG 481

Query: 392  TDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGK 447
               TA A     SL N+    P SS  K  P   G +      +  + +   +E  S   
Sbjct: 482  EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 541

Query: 448  AGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPS 507
                +P      +++ +  +     K   +K N  +S K  PV  G   PR  GTA  P 
Sbjct: 542  DSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP- 598

Query: 508  AVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQG 567
                                    +G +   A G   P     ED  S  ++D+     G
Sbjct: 599  ------------------------AGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTG 630

Query: 568  DSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRAS 627
             +V++G+  S  GK + V +  V PV      ++ +G    LP + G  VT  KA+ +  
Sbjct: 631  LAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVLPGKTGPTVTQVKAEKQED 684

Query: 628  GKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGE 687
             ++       +E +   +E AA+P +     +K    +   K +P + R      S KG 
Sbjct: 685  SES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAKANPAAAR----APSAKGT 728

Query: 688  PVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSSSSRQLDRKALGSARSPEG 740
              + GK  +A ++ K  SPS  KV P       S    +  +S   + +    +A++  G
Sbjct: 729  ISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 786

Query: 741  ARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAERSPCP-EAAAPPPGPRTRD 792
                 G  E +++  S  EA +L Q         + AA A     P + AAP P  +T  
Sbjct: 787  PEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 844

Query: 793  NFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSP----MSPQDGAGGSAFSFQAAPRA 848
            +  +A   + S       D+  +A A    +  + P    + P     G A +   A  A
Sbjct: 845  SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904

Query: 849  PSPPSRRDAGLQVSLGAAE---------TRSVATGPMTPQAAAPPAFPEVRVRPGSALAA 899
             +P   R +       ++E         T+ +  G  T     P A P  R+ P +++A 
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP--RIAPKASMAG 962

Query: 900  AVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPP 959
            A +  E +  + D    E        G A +V     A     +  ++   ++ + A PP
Sbjct: 963  ASSSKESSR-ISDGKKQE--------GPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1013

Query: 960  AARAGP--GRSGSVRTAP 975
             AR  P  G   +V T P
Sbjct: 1014 VARTQPSSGVDSAVGTLP 1031



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 110/529 (20%), Positives = 177/529 (33%), Gaps = 93/529 (17%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEA 112
            SPA P  TP Q+    +  ++ +      S S         P+  C +P    +  T+  
Sbjct: 890  SPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT 949

Query: 113  HGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPG 172
                I+  P+A+ +G     SS K   + SD +             ++  +T + K++P 
Sbjct: 950  AHPRIA--PKASMAG----ASSSKESSRISDGKK------------QEGPATQVSKKNPA 991

Query: 173  S------SRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSS--- 223
            S      + K       +A+P       PVA  R  P +     +G+L    P  +S   
Sbjct: 992  SLPLTQAALKVLAQKASEAQP-------PVA--RTQPSSGVDSAVGTLPATSPQSTSVQA 1042

Query: 224  --KTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRK-EEPRYSGKEHPVSSEKVAPTSAEK 280
                    P+  +     K    S D  D        E    G +   S+  + PT +  
Sbjct: 1043 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRT 1102

Query: 281  VDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPG 340
              LV             +    ES +      ++  L G + PG +  N   S  T    
Sbjct: 1103 ETLV-------------EETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1149

Query: 341  SLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT 400
            S   +  T     DP   G  E  P      +  G + P + G+           AS  T
Sbjct: 1150 SSPSVSSTLAAKDDPD--GKQEAKP-----QQAAGMLSPKTGGK---------EAASGTT 1193

Query: 401  DLTSLKNVDPMSSGKVDPVSLGKMDPMCS-GKPELLSPGQAERVSVGKAGTVSPGKEDPV 459
               S K      + +   ++L      C  G+P  L+  Q +  SV K  T      + +
Sbjct: 1194 PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ-ASVVKVLT------ELL 1246

Query: 460  SSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKG 519
               R+  +   + K SS K       K +      GD  +  T   P + K +    G+G
Sbjct: 1247 EQERKKVVD--TTKESSRKGWESRKRKLS------GDQPAART---PRSKKKKKLGAGEG 1295

Query: 520  DPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGD 568
               S      V+  K + T+ GKA+      +    KGK   G  G  D
Sbjct: 1296 GEAS------VSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKD 1338


>gi|112821690 G protein-regulated inducer of neurite outgrowth 3 [Homo
            sapiens]
          Length = 776

 Score =  100 bits (249), Expect = 7e-21
 Identities = 112/425 (26%), Positives = 169/425 (39%), Gaps = 74/425 (17%)

Query: 597  KAEAIPEG--KVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEA 654
            K  ++P G  K  S+ L   +   T K D R +G    +    A+ KL G   ++    A
Sbjct: 409  KLASLPGGVLKTSSINLVSSNAQHTCKEDGRLAGMTPVREESTAK-KLAGTNSSSLKATA 467

Query: 655  GAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLS 714
                         +++   +C +AE           LGK ++ PS   E  + G      
Sbjct: 468  ------------IDQISISACSQAET-------SYGLGKFETRPSEFAEKTTNGHKTDPD 508

Query: 715  LEKTKPSSS------SRQLDRKALGSARSPEGARGSEGRV-EPKAEPVSSTEASSLGQKD 767
             + +    S      S  LD    G AR  + A     +  E      S  +   L  K 
Sbjct: 509  CKLSDSCGSISKADHSGSLDPTNKGDAREKKPASPQVVKEKESTGTDTSDAKTLLLNPKS 568

Query: 768  LEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVS 827
             E+ G E      AA P P P  ++  +               +   Q      +S+   
Sbjct: 569  QESGGTE-----SAANPTPSPIRKNQESTL-------------EENRQTKTATSLSLPSD 610

Query: 828  PM---SPQDGAGGSAFSFQAAPRAPSPPSR--RDAGLQVSLGAAETRSVATGPMTPQAAA 882
            PM   SP  G    + S +A+PR PS  S   ++  L V+  AA            Q   
Sbjct: 611  PMGDSSPGSGKKTPSRSVKASPRRPSRVSEFLKEQKLNVTAAAA------------QVGL 658

Query: 883  PPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHL 942
             P   + ++   S L       + ++ VRDV WDE+GMTWEVYGA+++ E LG+AIQ HL
Sbjct: 659  TPGDKKKQLGADSKLQL-----KQSKRVRDVVWDEQGMTWEVYGASLDAESLGIAIQNHL 713

Query: 943  ERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSR 1002
            +RQI EH +           +   RS S  T+       R   +F+++LQ+ RRP CC R
Sbjct: 714  QRQIREHEKL-----IKTQNSQTRRSISSDTSSNKKLRGRQHSVFQSMLQNFRRPNCCVR 768

Query: 1003 AGPTA 1007
              P++
Sbjct: 769  PAPSS 773


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 167/788 (21%), Positives = 280/788 (35%), Gaps = 115/788 (14%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPT-----CFSPQESPSK 107
            SPA P    +++   E+   SP+G  E    +   + +L+   PT       + + +PS 
Sbjct: 437  SPAEPTENRERTAN-ENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSP 495

Query: 108  ETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIG 167
                 +G       E TTS   EP    +  P ++++  P   E  + +     + T+  
Sbjct: 496  AEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPS 555

Query: 168  KEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVD-----PLCS 222
              +P  +    P+   K  P +    +P   G+  P    K    S    +     PL +
Sbjct: 556  PAEPTENGDRTPLANEKTTPSL---AEPTENGQRTPFANEKTTSSSAEPTEHEERTPLAN 612

Query: 223  SKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPV----SSEKVAPTSA 278
              T   +P   +P   R+     +    P  P +     + ++  +     +E    T+ 
Sbjct: 613  ENT---TPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTAN 669

Query: 279  EKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGA 338
            EK     S   +P  +G+  P   E   S+S   TE            G+  P+++    
Sbjct: 670  EK---TTSSPAEPTENGQRTPFANEKTTSSSAEPTE-----------HGERTPLAN---- 711

Query: 339  PGSLGRLDPTCLGMADPAS----VGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
                   + T L  A+P        N +T P             PA   E R  + + +T
Sbjct: 712  -------ENTTLSPAEPTENRERTANEKTTPF------------PAEPTENRERTANENT 752

Query: 395  TAS-----AKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLS---PGQAERVSVG 446
            T S        D T L N +  +    +P   GK  P  + K    S      AER  + 
Sbjct: 753  TPSPAQPTENGDRTPLAN-EKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLA 811

Query: 447  KAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSG--KTNPVSSGPGDPRSLGTAG 504
               T S   E P  +R        ++  +    N ES+   KT P  + P + R      
Sbjct: 812  NENTTSSPAE-PTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANE 870

Query: 505  PPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPS 564
              +   AEP    +  PL++EK  L     A PT +G+  P    K  P S     A P+
Sbjct: 871  NTTLSPAEPTEHEEMTPLANEKTTL---SPAEPTENGERTPFTNEKTTPSS-----AEPT 922

Query: 565  GQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADP 624
              G+   +   ++TP +  P   G  + ++  KA   P     + P E G    TT  + 
Sbjct: 923  EHGERTPLANEITTPSRAEPTEHG--ERIANEKATPSP-----AKPTEHGE---TTVNED 972

Query: 625  RASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASG 684
                 A+P   G+  T L  +    +P E+     +     A+EK  P     AEP   G
Sbjct: 973  TTPSSAEPTENGE-RTPLANENTTTSPTES----TEHGERTANEKTTPS---PAEPTEHG 1024

Query: 685  KGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPS--SSSRQLDRKALGSAR---SPE 739
            +  P +  K   +P++ TE     ++ P + E T PS    +   ++  L + +   SPE
Sbjct: 1025 ERTPSANEKTIPSPAKPTEHE---EMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPE 1081

Query: 740  GARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPS 799
            G      +     E ++ + A             ER+  P          + ++  +A S
Sbjct: 1082 GPTEHGAKTTSANEKITPSLAK-------PTEHGERTTSPNDKITSSAAESTEHRDRATS 1134

Query: 800  WEASAPPP 807
                 P P
Sbjct: 1135 ANVITPAP 1142



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 156/782 (19%), Positives = 260/782 (33%), Gaps = 152/782 (19%)

Query: 254  PRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKT 313
            P   EP   G+  P +++K   +SAE  +    G+R P  +    P P E  ++      
Sbjct: 394  PSPAEPTEHGERTPFANDKTTSSSAESTE---HGERTPLANENTTPSPAEPTENRERTAN 450

Query: 314  EPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKE---- 369
            E        P  +G      +      +L  ++PT     +  +  N +T P+  E    
Sbjct: 451  E-----NTTPSPAGPTENRETTANEKTTLSPVEPT----ENRETTANEKTTPSPAEPTEN 501

Query: 370  --------DSRFLGKMDPASSGEGRPVSGHTDTTASAK---------TDLTSLKNVDPMS 412
                    +       +P   GE  P++    T + A+          + T+    +P  
Sbjct: 502  GQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTE 561

Query: 413  SGKVDPVSLGKMDPMCSGKPE--LLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISA- 469
            +G   P++  K  P  +   E    +P   E+ +   A      +  P+++    P  A 
Sbjct: 562  NGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAE 621

Query: 470  ---GSRKTSSEKVNPESSG-----------KTNPVSSGPGDPRSLGTAGPPSAVKAEPAT 515
                  +T++E   P  +G           KT    + P + R        ++  AEP  
Sbjct: 622  PTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTE 681

Query: 516  GGKGDPLSSEKAGLVASGKAAPTASGKAEPLA-----VGKEDPVSKGK------------ 558
             G+  P ++EK     S  A PT  G+  PLA     +   +P    +            
Sbjct: 682  NGQRTPFANEK---TTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPA 738

Query: 559  ----------------ADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGK---AE 599
                            + A P+  GD   +    +TP    P  +GK  P +  K   + 
Sbjct: 739  EPTENRERTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSS 798

Query: 600  AIPEGKVGSLPLEK----GSPVTTTKADPRASGK------AQPQSGGKAETKLPGQEGAA 649
            A P       PL       SP   T+   R + +      A+P    ++          A
Sbjct: 799  AEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPA 858

Query: 650  APGEAGAVCLKKET------PQASEKVDPGSCRK-----AEPLASGKGEPVSLGKADSAP 698
             P E       + T      P   E++ P +  K     AEP  +G+  P +  K   + 
Sbjct: 859  EPTENREWTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSS 918

Query: 699  SRKTESPSLGKVVPLSLEKTKPSSS------SRQLDRKALGSARSPE---GARGSEGRVE 749
            +  TE    G+  PL+ E T PS +       R  + KA  S   P        +E    
Sbjct: 919  AEPTEH---GERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVNEDTTP 975

Query: 750  PKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAA-----PPPGPRTRDNFTKAPSWEASA 804
              AEP  + E + L  ++   +  E +   E  A     P P   T        + E + 
Sbjct: 976  SSAEPTENGERTPLANENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTPSANEKTI 1035

Query: 805  PPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLG 864
            P P +     +    A  +   SP+ P +    +  + +    +P  P+           
Sbjct: 1036 PSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEH--------- 1086

Query: 865  AAETRSVATGPMTPQAAAPPAFPEVRVRPGS---------------ALAAAVAPPEPAEP 909
             A+T S A   +TP  A P    E    P                 A +A V  P PAEP
Sbjct: 1087 GAKTTS-ANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEP 1145

Query: 910  VR 911
            ++
Sbjct: 1146 IK 1147



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 116/574 (20%), Positives = 184/574 (32%), Gaps = 81/574 (14%)

Query: 370 DSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCS 429
           +S+ +       + E  P S    +       + + ++VDP  S      S GK      
Sbjct: 102 NSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKH---- 157

Query: 430 GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS--EKVNPESSGKT 487
                ++P    +++  K+ T   GK     +R+ D       K+ S  +K +  S   T
Sbjct: 158 -----ITPAPKSKINCRKSTT---GKS--TVTRKSDKTGRPLEKSMSTLDKTSTSSHKTT 207

Query: 488 NPV-SSGPGDPRSLGTAGPPSAVKAEPAT-GGKGDPLSSEKAG----LVASGKAAPTASG 541
               +SG    +   T+ P     A   T    G P  SEK       VAS K     + 
Sbjct: 208 TSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTK 267

Query: 542 KAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV---DPVSLGKA 598
             +      E   S     A P+  G   +     +TP    P  + +    +  +L  A
Sbjct: 268 NIQETISANELTQSL----AEPTEHGGRTANEN--NTPSPAEPTENRERTANENTTLSPA 321

Query: 599 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQ--SGGKAETKLPGQEGAAAPGEAGA 656
           E          P+E           P  +G  + +  +  +  T  P     A P E G 
Sbjct: 322 E----------PIENRERTANENTAPFPAGPTENREMTANENTTLFP-----AEPTEHGE 366

Query: 657 -VCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKA-----DSAPSRKTESPSLGKV 710
               +  TP  +E  + G     E       EP   G+      D   S   ES   G+ 
Sbjct: 367 RTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGER 426

Query: 711 VPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEA 770
            PL+ E T PS +    +R+   +  +     G     E  A   ++       +     
Sbjct: 427 TPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETT 486

Query: 771 AGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMS 830
           A  + +P P   A P     R  F    +  +SA P    +    A      +   SP  
Sbjct: 487 ANEKTTPSP---AEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANE----NTTPSPAE 539

Query: 831 PQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAET------------RSVATGPMTP 878
           P +    +A         PSP    + G +  L   +T            R+      T 
Sbjct: 540 PTENRERTA----NEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTT 595

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRD 912
            ++A P   E R    + LA     P PAEP  +
Sbjct: 596 SSSAEPTEHEER----TPLANENTTPSPAEPTEN 625


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 184/824 (22%), Positives = 296/824 (35%), Gaps = 139/824 (16%)

Query: 24  PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASC 83
           P     P  G +G  +  ++       K +  P   +     G ES   +P+G       
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293

Query: 84  SDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-S 142
           S+      A  +P     + +P K    A           T +GKPE  S   +E  S S
Sbjct: 294 SEKILQVRAASAPA----KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349

Query: 143 DDRNP----MFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198
           ++  P    +   K   K+S+   +++  KE P   RK                  P  P
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASAPAKESP---RKG---------------AAPAPP 391

Query: 199 GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
           G+  P   + +     GK +    S +      +E P   +        +     P KE 
Sbjct: 392 GKTGPAVAKAQ----AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKES 446

Query: 259 PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP- 315
           PR      P    K  P +A+    V  GK+  D   S +      E++ + +  + +P 
Sbjct: 447 PRKGAA--PAPPRKTGPAAAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500

Query: 316 GLLGKLIPGSSGKNGPVSSGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRF 373
           G   ++ P S+   GP+  G G   PG +G   P+       A VG  E      EDS  
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------AQVGKWE------EDSE- 546

Query: 374 LGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCS 429
                 +SS E    S     TA A     SL N+    P SS  K  P   G +     
Sbjct: 547 ------SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600

Query: 430 GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
            +  + +   +E  S       +P      +++ +  +     K   +K N  +S K  P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 490 VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
           V  G   PR  GTA  P                         +G +   A G   P    
Sbjct: 659 VRVGTQAPRKAGTATSP-------------------------AGSSPAVAGGTQRP---- 689

Query: 550 KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
            ED  S  ++D+     G +V++G+  S  GK + V +  V PV      ++ +G    L
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVL 743

Query: 610 PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
           P + G  VT  KA+ +   ++       +E +   +E AA+P +     +K    +   K
Sbjct: 744 PGKTGPTVTQVKAEKQEDSES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAK 791

Query: 670 VDPGSCRKAEPLASGKGEPVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSS 722
            +P + R      S KG   + GK  +A ++ K  SPS  KV P       S    +  +
Sbjct: 792 ANPAAAR----APSAKGTISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPA 845

Query: 723 SSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAER 775
           S   + +    +A++  G     G  E +++  S  EA +L Q         + AA A  
Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 776 SPCP-EAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGA 818
              P + AAP P  +T  +  +A   + S       D+  +A A
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA 947



 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 206/897 (22%), Positives = 316/897 (35%), Gaps = 194/897 (21%)

Query: 48  SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDG------PRGSLACPSPTCFSP 101
           S+ +   + P       PGM S  ++ S + + +S SD       P    A    +  S 
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVST 230

Query: 102 QESPSKETLEAHGASISGTPE--------ATTSGKPEPVSSVKTEPKSSDDRNPMFLEKM 153
           +ESP+++   A G     TP+        A  + KPE  S    E   S++  P      
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP-----A 285

Query: 154 DFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKG-DPVAPGRMDPMTVRKEDLG 212
             +S  +A    +      +  K  P           GKG  P  PG+     V  +   
Sbjct: 286 GTRSQVKASEKILQVRAASAPAKGTP-----------GKGATPAPPGKAG--AVASQTKA 332

Query: 213 SLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPV----FPRKEEPRYSGKEHPV 268
              + D   SS+  + S  +E P +   +   +S K   V     P KE PR      P 
Sbjct: 333 GKPEEDSESSSEESSDS-EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA--PA 389

Query: 269 SSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK 328
              K  P  A+      +GKR+      +     E  DS      +    GK  P     
Sbjct: 390 PPGKTGPAVAK----AQAGKREEDSQSSS-----EESDSEEEAPAQAKPSGK-APQVRAA 439

Query: 329 NGPVSSGT---GAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEG 385
           + P         AP    +  P     A    VG  E      EDSR        SS E 
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPA----AAQVQVGKQE------EDSR--------SSSE- 480

Query: 386 RPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSV 445
                 +D  A A  +   +K +    S +V P S   M P+  G               
Sbjct: 481 ---ESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKG--------------- 520

Query: 446 GKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGP 505
             AG V PGK  P +   +        ++SSE+ +  S G+  P +  P   +SLG    
Sbjct: 521 --AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV-PTAVAPAQEKSLG---- 573

Query: 506 PSAVKAEPATG-GKGDPLSSEKAGLVASGKAA------PTASGKAEPLAVGKEDPVSKGK 558
            + ++A+P +   KG P   +KAG VA    A        +S ++   A  +E P +   
Sbjct: 574 -NILQAKPTSSPAKGPP---QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 559 ADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVT 618
           A A P     ++ I +  + P KT    S KV PV +G                      
Sbjct: 630 AQAKP-----ALKIPQTKACPKKTNTTASAKVAPVRVG---------------------- 662

Query: 619 TTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKA 678
            T+A PR +G A   +G             ++P  AG      E   +SE+ D    +  
Sbjct: 663 -TQA-PRKAGTATSPAG-------------SSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 679 EPLASGKGEPVSLG---KADSAPSRKTESPSLGKVVP---------LSLEKTKPSSSSRQ 726
             +  G+ + V  G   KA S P + +       V+P         +  EK + S SS +
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE 767

Query: 727 LDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-----KDLEAAGAERSPCPEA 781
            +  +  +A SP   + S  + + KA P ++   S+ G      K + AA   +   P  
Sbjct: 768 -ESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826

Query: 782 AAPP-----------PGPRTRDNFTKAPSWEASAPPPPREDAG-----TQAGAQACVSVA 825
             PP            GP +  +  KA +  A A   P ED+G     + +  +A     
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQ 886

Query: 826 VSPMSPQDGAGGSAFSFQAAPR---APSP-----PSRRDAGLQVSLGAAETRSVATG 874
           V P         +    + +PR   AP+P     PS   AG Q   G++   S + G
Sbjct: 887 VKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 943



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 121/506 (23%), Positives = 169/506 (33%), Gaps = 70/506 (13%)

Query: 439 QAERVSVGKAGTVSPGKEDPVSSRREDPISAGS--RKTSSEKVNPESSGKTNPVSSGPGD 496
           +AE    GK G   P    P + +    + +G   RK++    N     +T    S P  
Sbjct: 126 KAETEKAGKTGNSMP---HPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP-- 180

Query: 497 PRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSK 556
             + G A  P  V A  A     D  SS     V    +   A  KA  ++  KE P  K
Sbjct: 181 --AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVST-KESPARK 237

Query: 557 GKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSP 616
                G  G       G  +  P K    P  + +    G +E+  E   G+    K S 
Sbjct: 238 AAPAPGKVGDVTPQVKGGALP-PAKRAKKPEEESESSEEG-SESEEEAPAGTRSQVKASE 295

Query: 617 VTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK-------------KET 663
                    A  K  P   GK  T  P       PG+AGAV  +              E 
Sbjct: 296 KILQVRAASAPAKGTP---GKGATPAP-------PGKAGAVASQTKAGKPEEDSESSSEE 345

Query: 664 PQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSS 723
              SE+  P +    +  ASGK   V    A SAP++  ESP  G   P    KT P+ +
Sbjct: 346 SSDSEEETPAAKALLQAKASGKTSQVG---AASAPAK--ESPRKG-AAPAPPGKTGPAVA 399

Query: 724 SRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAA 783
             Q  ++   S  S E +   E        P  +  +    Q    +A A+ SP   AA 
Sbjct: 400 KAQAGKREEDSQSSSEESDSEE------EAPAQAKPSGKAPQVRAASAPAKESPRKGAAP 453

Query: 784 PPP---GPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPM------SPQDG 834
            PP   GP       +    E  +     E    +    A  +  V P+       P   
Sbjct: 454 APPRKTGPAAAQ--VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511

Query: 835 AGGSAFSFQAAPRAPSPPSRRDAGLQV------SLGAAETRSVATGPMTPQAAAPPAFPE 888
            G       A P  P          QV      S  ++E  S ++    P A AP     
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571

Query: 889 ----VRVRPGSALAAAVAPPEPAEPV 910
               ++ +P S  + A  PP+ A PV
Sbjct: 572 LGNILQAKPTS--SPAKGPPQKAGPV 595


>gi|239747654 PREDICTED: hypothetical protein XP_002348126 [Homo
           sapiens]
          Length = 1032

 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 159/563 (28%), Positives = 202/563 (35%), Gaps = 28/563 (4%)

Query: 171 PGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSP 230
           PG +  + P   GKA     GK     PG+       K  +   GK       K     P
Sbjct: 289 PGKAIVSGP---GKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGLGKAIVSGP 345

Query: 231 RKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRD 290
            K     L K    S  K     P K      GK       K   +S  K  +   GK  
Sbjct: 346 GKAIVSGLGKAIVSSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAI 405

Query: 291 PGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCL 350
               GKA    L     +  GK      GK I    GK      G       G+   + L
Sbjct: 406 VSGPGKAIVSGLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSL 465

Query: 351 GMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPV---SGHTDTTASAKTDLTSLKN 407
           G A   S+G        K      GK     SG G+ +    G    ++  K  + SL  
Sbjct: 466 GKAIVCSLGKAIVSGPGKAIVSGPGKA--IVSGPGKAIVSGPGKAIISSLGKAIVCSLGK 523

Query: 408 VDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPI 467
                 GK     LGK      GK  + S G+A   S+GKA    PGK   VSS  +  +
Sbjct: 524 AIVSGPGKAIVSGLGKAIVSSLGKAIVSSLGKAIVSSLGKAIVSGPGKAI-VSSPGKAIV 582

Query: 468 SAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKA 527
           S   +   S       SG    + SGPG       + P  A+ + P   GK    S  KA
Sbjct: 583 SGPGKAIVSGPGKAIVSGPGKAIVSGPGKAI---VSSPGKAIVSGP---GKAIVSSPGKA 636

Query: 528 GLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGK-VVSTPGKTVPVP 586
            + + GKA  ++ GKA   + GK    S GKA     G+    S+GK +VS PGK +   
Sbjct: 637 IVSSPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVSSLGKAIVSGPGKAIVSG 696

Query: 587 SGKVDPVSLGKAEAIPEGK--VGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPG 644
            GK      GKA     GK  V SL           KA     GKA   S GKA    PG
Sbjct: 697 PGKAIVSGPGKAIVSSPGKAIVSSLG----------KAIVSGPGKAIVSSPGKAIVSGPG 746

Query: 645 QEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTES 704
           +   ++PG+A      K       K    S  KA   + GK     LGKA  +   K   
Sbjct: 747 KAIVSSPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIVSGLGKAIVSSPGKAIV 806

Query: 705 PSLGKVVPLSLEKTKPSSSSRQL 727
            SLGK +  SL K   SS  + +
Sbjct: 807 SSLGKAIVSSLGKAIVSSLGKAI 829



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 173/634 (27%), Positives = 228/634 (35%), Gaps = 55/634 (8%)

Query: 105 PSKETLEAHG-ASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADS 163
           P K  +   G A +SG  +A  SG   P  ++ + P  +    P    K       +A  
Sbjct: 257 PGKAIVSGLGKAIVSGPGKAIVSG---PGKAIVSGPGKAIVSGP---GKAIVSGPGKAIV 310

Query: 164 TSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSS 223
           +  GK       KA     GKA    LGK     PG+     + K  + SLGK       
Sbjct: 311 SGPGKAIVSGPGKAIVSGPGKAIVSGLGKAIVSGPGKAIVSGLGKAIVSSLGKAIVSGPG 370

Query: 224 KTYTVSPRK---EDPG-----SLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAP 275
           K     P K     PG     SL K    S  K     P K      GK       K   
Sbjct: 371 KAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIVSGPGKAIV 430

Query: 276 TSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK------- 328
           +   K  +   GK      GKA          +S GK     LGK I    GK       
Sbjct: 431 SGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGPG 490

Query: 329 ----NGPVSSGTGAPG-----SLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDP 379
               +GP  +    PG     SLG+     LG A  +  G        K     LGK   
Sbjct: 491 KAIVSGPGKAIVSGPGKAIISSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIVSSLGKAIV 550

Query: 380 ASSGE------GRPV---SGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSG 430
           +S G+      G+ +    G    ++  K  ++          GK      GK      G
Sbjct: 551 SSLGKAIVSSLGKAIVSGPGKAIVSSPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPG 610

Query: 431 KPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSE-KVNPESSGKTNP 489
           K  + SPG+A     GKA   SPGK    S  +    S G    SS  K    S GK   
Sbjct: 611 KAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVSSPGKAIV 670

Query: 490 VSSGPGDPRSLGTA---GPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPL 546
            S G     SLG A   GP  A+ + P   GK       KA + + GKA  ++ GKA   
Sbjct: 671 SSPGKAIVSSLGKAIVSGPGKAIVSGP---GKAIVSGPGKAIVSSPGKAIVSSLGKAIVS 727

Query: 547 AVGKEDPVSKGKADAGPSGQGDSVSIGK-VVSTPGKTVPVPSGKVDPVSLGKAEAIPEGK 605
             GK    S GKA     G+    S GK +VS+PGK +    GK    S GKA     GK
Sbjct: 728 GPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGK 787

Query: 606 VGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAV-CLKKETP 664
                L K    +  KA   + GKA   S GKA     G+   + PG+A ++  +   TP
Sbjct: 788 AIVSGLGKAIVSSPGKAIVSSLGKAIVSSLGKAIVSSLGKAIVSGPGKAISIRVMTILTP 847

Query: 665 QASEKVDPGS------CRKAEPLASGKGEPVSLG 692
           +    +   S      C+  + + SG G+ +  G
Sbjct: 848 ECILNLFHFSHLLHLLCQPPKAIVSGPGKAIVSG 881



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 174/659 (26%), Positives = 226/659 (34%), Gaps = 62/659 (9%)

Query: 115  ASISGTPEATTSGKPEPVSSV--KTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPG 172
            A +SG  +A  SG  + + S   K    S        L K       +A  + +GK    
Sbjct: 364  AIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIVS 423

Query: 173  SSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRK 232
               KA     GKA     GK     PG+       K  + SLGK       K     P K
Sbjct: 424  GPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGK 483

Query: 233  EDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPG 292
                   K       K     P K      GK    S  K   +   K  +   GK    
Sbjct: 484  AIVSGPGKAIVSGPGKAIVSGPGKAIISSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIVS 543

Query: 293  PSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK---NGPVSSGTGAPGSL-----GR 344
              GKA    L     +S GK      GK I  S GK   +GP  +    PG       G+
Sbjct: 544  SLGKAIVSSLGKAIVSSLGKAIVSGPGKAIVSSPGKAIVSGPGKAIVSGPGKAIVSGPGK 603

Query: 345  LDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVS-GHTDTTASAKTDLT 403
               +  G A  +S G        K      GK   +S G+    S G    ++  K  ++
Sbjct: 604  AIVSGPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVSSPGKAIVS 663

Query: 404  SLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRR 463
            S       S GK    SLGK      GK  +  PG+A     GKA   SPGK   VSS  
Sbjct: 664  SPGKAIVSSPGKAIVSSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSPGKAI-VSSLG 722

Query: 464  EDPISAGSRKTSSEKVNPESSGKTNPVSSGPG-----DPRSLGTAGPPSAVKAEPATGGK 518
            +  +S   +   S       SG    + S PG      P     +GP  A+ + P   GK
Sbjct: 723  KAIVSGPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIVSGPGKAIVSSP---GK 779

Query: 519  GDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKA------DAGPSGQGDSVSI 572
                S  KA +   GKA  ++ GKA   ++GK    S GKA       A  SG G ++SI
Sbjct: 780  AIVSSPGKAIVSGLGKAIVSSPGKAIVSSLGKAIVSSLGKAIVSSLGKAIVSGPGKAISI 839

Query: 573  G----------------------------KVVSTPGKTVPVPSGKVDPVSLGKA------ 598
                                          +VS PGK +    GK      GKA      
Sbjct: 840  RVMTILTPECILNLFHFSHLLHLLCQPPKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPG 899

Query: 599  EAIPEGKVGSLPLEKGSPVTTT--KADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGA 656
            +AI  G   ++    G  + +   KA     GKA     GKA    PG+   ++PG+A  
Sbjct: 900  KAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSPGKAIV 959

Query: 657  VCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSL 715
              L K       K       KA     GK      GKA  +   K    SLGK +  SL
Sbjct: 960  SGLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSPGKAIVSSLGKAIVSSL 1018



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 118/411 (28%), Positives = 151/411 (36%), Gaps = 20/411 (4%)

Query: 323 PGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASS 382
           PG +  +GP  +    PG      P   G A  +  G        K     LGK     S
Sbjct: 137 PGKAIVSGPGKAIVSGPGKAIVSGP---GKAIVSGPGKAIVSGPGKAIVSGLGKA--IVS 191

Query: 383 GEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER 442
           G G+ +      +   K  ++SL        GK      GK      GK  + S G+A  
Sbjct: 192 GPGKAI-----VSGLGKAIVSSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIV 246

Query: 443 VSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGD-----P 497
            S+GKA    PGK   VS   +  +S   +   S       SG    + SGPG      P
Sbjct: 247 CSLGKAIVSGPGKAI-VSGLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGP 305

Query: 498 RSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKG 557
                +GP  A+ + P   GK       KA +   GKA  +  GKA    +GK    S G
Sbjct: 306 GKAIVSGPGKAIVSGP---GKAIVSGPGKAIVSGLGKAIVSGPGKAIVSGLGKAIVSSLG 362

Query: 558 KADAGPSGQGDSVSIGK-VVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSP 616
           KA     G+      GK +VS PGK +    GK    SLGKA     GK     L K   
Sbjct: 363 KAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIV 422

Query: 617 VTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCR 676
               KA     GKA     GKA    PG+   + PG+A    L K    +  K       
Sbjct: 423 SGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPG 482

Query: 677 KAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQL 727
           KA     GK      GKA  +   K    SLGK +  SL K   S   + +
Sbjct: 483 KAIVSGPGKAIVSGPGKAIVSGPGKAIISSLGKAIVCSLGKAIVSGPGKAI 533



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 138/487 (28%), Positives = 178/487 (36%), Gaps = 49/487 (10%)

Query: 287 GKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK---NGPVSSGTGAPGSL- 342
           GK      GKA    L     +  GK     LGK I  S GK   +GP  +    PG   
Sbjct: 170 GKAIVSGPGKAIVSGLGKAIVSGPGKAIVSGLGKAIVSSLGKAIVSGPGKAIVSGPGKAI 229

Query: 343 ----GRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPV---SGHTDTT 395
               G+   + LG A   S+G        K     LGK     SG G+ +    G    +
Sbjct: 230 VSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGLGKA--IVSGPGKAIVSGPGKAIVS 287

Query: 396 ASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGK 455
              K  ++          GK      GK      GK  +  PG+A    +GKA    PGK
Sbjct: 288 GPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGLGKAIVSGPGK 347

Query: 456 EDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDP--RSLGTA---------- 503
              VS   +  +S+  +   S       SG    + SGPG     SLG A          
Sbjct: 348 AI-VSGLGKAIVSSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIV 406

Query: 504 -GPPSAV-------------KAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
            GP  A+             KA  +  GK       KA +   GKA  +  GKA   ++G
Sbjct: 407 SGPGKAIVSGLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLG 466

Query: 550 KEDPVSKGKAD-AGP-----SGQGDSVSIGK---VVSTPGKTVPVPSGKVDPVSLGKAEA 600
           K    S GKA  +GP     SG G ++  G    +VS PGK +    GK    SLGKA  
Sbjct: 467 KAIVCSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIISSLGKAIVCSLGKAIV 526

Query: 601 IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
              GK     L K    +  KA   + GKA   S GKA    PG+   ++PG+A      
Sbjct: 527 SGPGKAIVSGLGKAIVSSLGKAIVSSLGKAIVSSLGKAIVSGPGKAIVSSPGKAIVSGPG 586

Query: 661 KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKP 720
           K       K       KA     GK    S GKA  +   K    S GK +  S  K   
Sbjct: 587 KAIVSGPGKAIVSGPGKAIVSGPGKAIVSSPGKAIVSGPGKAIVSSPGKAIVSSPGKAIV 646

Query: 721 SSSSRQL 727
           SS  + +
Sbjct: 647 SSPGKAI 653



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 93/336 (27%), Positives = 126/336 (37%), Gaps = 42/336 (12%)

Query: 430 GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
           GK  +  PG+A     GKA    PGK   VS   +  +S   +   S       SG    
Sbjct: 42  GKAIVSGPGKAIVSGPGKAIVSGPGKAI-VSGPGKAIVSGPGKAIVSGPGKAIVSGPGKA 100

Query: 490 VSSGPGD-----PRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAE 544
           + SGPG      P     +GP  A+ + P   GK       KA +   GKA  +  GKA 
Sbjct: 101 IVSGPGKAIVSGPGKAIVSGPGKAIVSGP---GKAIVSGPGKAIVSGPGKAIVSGPGKAI 157

Query: 545 PLAVGKEDPVSKGKADAGPSGQGDSVSIGK-VVSTPGKTVPVPSGKVDPVSLGKA----- 598
               GK      GKA     G+     +GK +VS PGK +    GK    SLGKA     
Sbjct: 158 VSGPGKAIVSGPGKAIVSGPGKAIVSGLGKAIVSGPGKAIVSGLGKAIVSSLGKAIVSGP 217

Query: 599 -EAIPEGKVGSLPLEKGSPVTTT------------------KADPRASGKAQPQSGGKAE 639
            +AI  G   ++    G  + ++                  KA     GKA     GKA 
Sbjct: 218 GKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGKAIVSGLGKAIVSGPGKAI 277

Query: 640 TKLPGQEGAAAPGEA---GAVCLKKETPQASEKVDPGSCRKAEP---LASGKGEPV--SL 691
              PG+   + PG+A   G        P  +    PG    + P   + SG G+ +   L
Sbjct: 278 VSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGL 337

Query: 692 GKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQL 727
           GKA  +   K     LGK +  SL K   S   + +
Sbjct: 338 GKAIVSGPGKAIVSGLGKAIVSSLGKAIVSGPGKAI 373



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 24/242 (9%)

Query: 505 PPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKA-DAGP 563
           PP A+ + P   GK       KA +   GKA  +  GKA     GK      GKA  +GP
Sbjct: 25  PPKAIVSGP---GKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGP 81

Query: 564 -----SGQGDSVSIG---KVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGS 615
                SG G ++  G    +VS PGK +    GK   +  G  +AI  G   ++    G 
Sbjct: 82  GKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKA--IVSGPGKAIVSGPGKAIVSGPGK 139

Query: 616 PVTT--TKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPG 673
            + +   KA     GKA     GKA    PG+   + PG+A    L K       K    
Sbjct: 140 AIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSGLGKAIVSGPGKAIVS 199

Query: 674 SCRKA------EPLASGKGEPV--SLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSR 725
              KA      + + SG G+ +    GKA  +   K    SLGK +  SL K   S   +
Sbjct: 200 GLGKAIVSSLGKAIVSGPGKAIVSGPGKAIVSGPGKAIVSSLGKAIVCSLGKAIVSGPGK 259

Query: 726 QL 727
            +
Sbjct: 260 AI 261


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 257/1000 (25%), Positives = 321/1000 (32%), Gaps = 147/1000 (14%)

Query: 20   PGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAG- 78
            PG +    F   DG+ G    A     P     + AP +  P   PG   R  +P  AG 
Sbjct: 262  PGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGA 321

Query: 79   ---EGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTS--GKPEPVS 133
               +GA+ + GP G      P  F P    +K      G   S  P+      G P P  
Sbjct: 322  RGNDGATGAAGPPGPTGPAGPPGF-PGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAG 380

Query: 134  SVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKG 193
            +         D  P        K +  A   +     PG+   + P   G         G
Sbjct: 381  AAGPAGNPGADGQP------GAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSG 434

Query: 194  DPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVF 253
            +P APG        K D G+ G                  +PG +    P      +   
Sbjct: 435  EPGAPG-------SKGDTGAKG------------------EPGPVGVQGPPGPAGEEGKR 469

Query: 254  PRKEEPRYSGKEHPVSSEKVAPTSA--EKVDLVLSGKRDPGPSGKADPMPLESMDSASTG 311
              + EP  +G   P   E+  P S      D V   K   G  G   P   +     +  
Sbjct: 470  GARGEPGPTGLPGP-PGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGR 528

Query: 312  KTEPGLLG-KLIPGSSGKNGPVSSGTGAPGSLGRLD-PTCLGMADPASVGNVETVPATKE 369
              E GL G K + GS G  GP    TG PG  G+   P   G         V   P  K 
Sbjct: 529  PGEAGLPGAKGLTGSPGSPGP-DGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKG 587

Query: 370  DSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCS 429
             +      +P  +GE R V G       A  D  +     P  +G       G+  P  +
Sbjct: 588  AAG-----EPGKAGE-RGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAG--ERGEQGP--A 637

Query: 430  GKPELLS-PGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTN 488
            G P     PG A     G  G      E  V      P  +G+R    E+  P   G   
Sbjct: 638  GSPGFQGLPGPA-----GPPGEAGKPGEQGVPGDLGAPGPSGAR---GERGFPGERGVQG 689

Query: 489  PVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAV 548
            P   GP  PR  G  G P    A+   G  G P S    GL    +  P   G     A 
Sbjct: 690  P--PGPAGPR--GANGAPGNDGAKGDAGAPGAPGSQGAPGL----QGMPGERG-----AA 736

Query: 549  GKEDPVSKG-KADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVG 607
            G   P  KG + DAGP G   S         PGK      G   P+        P G  G
Sbjct: 737  GLPGP--KGDRGDAGPKGADGS---------PGK--DGVRGLTGPIG-------PPGPAG 776

Query: 608  SLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEG-AAAPGEAGAVCLKKETPQA 666
            + P +KG    +  A P     A+   G + E   PG  G A  PG  G    K E   A
Sbjct: 777  A-PGDKGESGPSGPAGPTG---ARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDA 832

Query: 667  SEKVDPGSCRKAEPLA-----SGKGEPVSLGKADSA-PSRKTESP-SLGKVVPLSLE-KT 718
              K D G    A P          G P + G   SA P   T  P + G+V P       
Sbjct: 833  GAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNA 892

Query: 719  KPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPC 778
             P        ++     R   G  G  G V P   P  + E  S G      AGA  +P 
Sbjct: 893  GPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADG--PAGAPGTPG 950

Query: 779  PEAAAPP------PGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQ 832
            P+  A        PG R    F   P     +  P ++     +G +        PM P 
Sbjct: 951  PQGIAGQRGVVGLPGQRGERGF---PGLPGPSGEPGKQGPSGASGERG----PPGPMGPP 1003

Query: 833  DGAGGSAFS-FQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAA--APPAFPEV 889
              AG    S  + AP A   P R       S GA   R   TGP  P  A  AP A   V
Sbjct: 1004 GLAGPPGESGREGAPGAEGSPGR-----DGSPGAKGDRG-ETGPAGPPGAPGAPGAPGPV 1057

Query: 890  RVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEH 949
                 S       P  PA PV  V            G   E    G       +R I+ H
Sbjct: 1058 GPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQG-------DRGIKGH 1110

Query: 950  ----GRQGAPAPP--PAARAGPGRSGSVRTAPPDGAAKRP 983
                G QG P PP  P  +   G SG      P G+A  P
Sbjct: 1111 RGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAP 1150



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 192/742 (25%), Positives = 238/742 (32%), Gaps = 114/742 (15%)

Query: 291 PGPSGKADPMPLES--MDSASTGKTEPGLLGKLIPGSSGKNGP--VSSGTGAPGSLGRL- 345
           PGP G   P  L        S G  E    G  +PG  G +GP  +    GAPG  G   
Sbjct: 144 PGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQG 203

Query: 346 ---DPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDL 402
              +P   G + P         P    D    GK  P   GE  P              L
Sbjct: 204 PPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGK--PGRPGERGPPGPQGARGLPGTAGL 261

Query: 403 TSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSR 462
             +K     S         G   P    K E  SPG+      G  G + P        R
Sbjct: 262 PGMKGHRGFSGLDGAKGDAGPAGP----KGEPGSPGEN-----GAPGQMGPRGLPGERGR 312

Query: 463 REDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT---AGP--------PSAVKA 511
              P  AG+R            G T P    PG P ++G    AGP        P  V+ 
Sbjct: 313 PGAPGPAGARGNDGATGAAGPPGPTGPAGP-PGFPGAVGAKGEAGPQGPRGSEGPQGVRG 371

Query: 512 EP-------ATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPS 564
           EP       A G  G+P +  + G   +  A   A     P A G   P   G       
Sbjct: 372 EPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKG 431

Query: 565 GQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADP 624
             G+  + G    T  K  P P G   P       A  EGK G+    +G P  T    P
Sbjct: 432 NSGEPGAPGSKGDTGAKGEPGPVGVQGP----PGPAGEEGKRGA----RGEPGPTGLPGP 483

Query: 625 RASGKAQPQSGGKAETKLPGQEGAAAP-GEAGAVCLKKETPQASEKVDPGSCRKAEPLAS 683
                   + GG      PG +G A P G AG            E+  PG        A 
Sbjct: 484 PG------ERGGPGSRGFPGADGVAGPKGPAG------------ERGSPGP-------AG 518

Query: 684 GKGEPVSLGKADSA--PSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRK-------ALGS 734
            KG P   G+   A  P  K  + S G   P    KT P   + Q  R        A G 
Sbjct: 519 PKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDG--KTGPPGPAGQDGRPGPPGPPGARGQ 576

Query: 735 A-----RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPR 789
           A       P+GA G  G+   +  P         G KD E AGA+  P P   A P G R
Sbjct: 577 AGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAG-KDGE-AGAQGPPGP---AGPAGER 631

Query: 790 TRDNFTKAPSWEA-SAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRA 848
                  +P ++    P  P  +AG + G Q       +P  P    G   F  +   + 
Sbjct: 632 GEQGPAGSPGFQGLPGPAGPPGEAG-KPGEQGVPGDLGAP-GPSGARGERGFPGERGVQG 689

Query: 849 PSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPP---- 904
           P  P    AG + + GA            P A      P ++  PG   AA +  P    
Sbjct: 690 PPGP----AGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDR 745

Query: 905 -EPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARA 963
            +      D S  + G    V G    +   G A          E G  G PA P  AR 
Sbjct: 746 GDAGPKGADGSPGKDG----VRGLTGPIGPPGPA---GAPGDKGESGPSG-PAGPTGARG 797

Query: 964 GPGRSGSVRTAPPDGAAKRPPG 985
            PG  G      P G A  PPG
Sbjct: 798 APGDRGEPGPPGPAGFA-GPPG 818


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 143/687 (20%), Positives = 251/687 (36%), Gaps = 77/687 (11%)

Query: 111  EAHGASISGTPEATTSGKPEPVSS----VKTEPKSSDDRNPMFLEKMDFKSSKQADSTSI 166
            EA G +++   E  T        S     + E +   +R     +    + + Q ++ + 
Sbjct: 1762 EAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAG 1821

Query: 167  GKEDPGSSRKAD----PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCS 222
            G +DPG S  A+    P   G+A+PE  G   P A G               G+  P   
Sbjct: 1822 GDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE---------GEAQP--- 1869

Query: 223  SKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVD 282
                  S   E P +  +  P S D   P    + +P   G E P + ++  P +     
Sbjct: 1870 -----ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924

Query: 283  LVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNG--PVSSGTGA-- 338
            L   G+ +P   G A+    E     + G+T+P    ++I     +    P S    A  
Sbjct: 1925 LETEGEDEPESEG-AEAQEAEEAAQEAEGQTQPE--SEVIESQEAEEEAQPESEDVEALE 1981

Query: 339  -----PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGE-GRPVSGHT 392
                   + G   P    +  P + G ++      +      +  P S GE  + V G T
Sbjct: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041

Query: 393  DTT-ASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTV 451
              T   A+ +   ++  +     +     + + +     + E +   +AE    G+A   
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE----GEAQPE 2097

Query: 452  SPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKA 511
            S G E P +              +  +  PES G   P + G   P S G     +  +A
Sbjct: 2098 SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEA 2157

Query: 512  EPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVS 571
            +P + G     + E+A     G  AP A G+A+P + G E P ++G+A     G      
Sbjct: 2158 QPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGV----- 2212

Query: 572  IGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQ 631
              +      +  P P G   P + G+A+  PE +  +   +KGSP  +        G  Q
Sbjct: 2213 --EAPEAEEEAQPEPEGVETPEAEGEAQ--PESEGETQGEKKGSPQVSL-------GDGQ 2261

Query: 632  PQSGGKAETKLPGQEGAAAPGEAGAVCLKK----ETPQASEKVDPGSCRKAEPLASGKGE 687
             +   ++ + +P       P   G    ++      P +S     G+C + +     + +
Sbjct: 2262 SEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD----SEND 2317

Query: 688  PVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGA-RGSEG 746
             V LG   S  ++ T +P   +       +  P SS+ + +   LGS    +GA  G + 
Sbjct: 2318 HV-LGDTRSPDAKSTGTPHAER----KATRMYPESSTSEQEEAPLGSRTPEQGASEGYDL 2372

Query: 747  RVEPKAEPVSSTE----ASSLGQKDLE 769
            + +     ++ TE    A   GQ DL+
Sbjct: 2373 QEDQALGSLAPTEAVGRADGFGQDDLD 2399



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 149/658 (22%), Positives = 236/658 (35%), Gaps = 101/658 (15%)

Query: 284  VLSGKRDPGPSGKA-DPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGS- 341
            +L  KR     G+A +  P ++    ++ +T  G  G L PG S   G V  G    GS 
Sbjct: 1692 ILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPG-VDEGEDGEGSQ 1750

Query: 342  ---------LGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHT 392
                     LG  +   +         N ET   ++     LG+ +    GEG    G T
Sbjct: 1751 RLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSE-----LGEAE--QEGEGISERGET 1803

Query: 393  DTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVS 452
                S   D           + + +  + G  DP  S   E +   +AE           
Sbjct: 1804 GGQGSGHED-----------NLQGEAAAGGDQDPGQSDGAEGIEAPEAE----------- 1841

Query: 453  PGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAE 512
             G+  P S   E P + G  + +  +  PES     P + G   P S     P +  + +
Sbjct: 1842 -GEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ 1900

Query: 513  PATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSI 572
            P + G   P + ++A        A    G+ EP + G E   ++   +A    +G +   
Sbjct: 1901 PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE---AQEAEEAAQEAEGQTQPE 1957

Query: 573  GKVVSTPGKTVPVPSGKVDPVSL--------GKAEAIPEGKVGSLPLEKGS-PVTTTKAD 623
             +V+ +            D  +L         + EA PE +    P  +G       +A 
Sbjct: 1958 SEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017

Query: 624  PRASG-KAQPQSGGKAETKLPGQ----EGAAAPGEAGAVCLKKETPQASEKVDP--GSCR 676
            P + G +AQP+S G+   ++ G+    EG A P   G      E P+A E+     G  +
Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGV-----EAPEAEEEAQEAEGEVQ 2072

Query: 677  KAEPLASGKGEPVSLGKADS----------APSRKTESPSL-GKVVPLSLEKTKPSSSSR 725
            +AE  A  + E V   +A+           AP  + E+    G   P +  + +P S   
Sbjct: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI 2132

Query: 726  QLDRKALGSARSPEG--ARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAA 783
            +       +    EG  A+ +EG  +P++E + + EA    Q +LE   A   P  E  A
Sbjct: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA---PEAEGEA 2189

Query: 784  PPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQ 843
             P          +AP  E  A P        +A  +A            +G        +
Sbjct: 2190 QP-----ESEGIEAPEAEGEAQPELEGVEAPEAEEEA--------QPEPEGVETPEAEGE 2236

Query: 844  AAPRAPSPPSRRDAGL-QVSL--GAAETRSVATGPMTPQAAAPPAFP---EVRVRPGS 895
            A P +         G  QVSL  G +E  S ++ P+      PP  P       RPGS
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGS 2294



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 130/537 (24%), Positives = 176/537 (32%), Gaps = 132/537 (24%)

Query: 468 SAGSRKTSSEKVNPESS-----GKTNPVSSGPGDPRS-LGTAGPPSAVKAEPATGGKGDP 521
           +AG  + S +  +P SS     G     S  P  P   + +A P + + AE   GG    
Sbjct: 442 TAGRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGS--- 498

Query: 522 LSSEKAGLV--ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP 579
              E  GL    +G   P   G+  P A  +E   S   A  G S +G S   G+    P
Sbjct: 499 -LGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTG-SHEGSSEWGGRPQGCP 556

Query: 580 GKTVPVPSGKV-----DPVSLG-----------KAEAIPEGK-------VGSLPLEKG-- 614
           GK     S +      DP S             +AE   +G        V   PL  G  
Sbjct: 557 GKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLS 616

Query: 615 ----------SPVTTTKADP-------RASGKAQPQSGG---------------KAETKL 642
                     +P T T +         RAS  + P S G               + +T  
Sbjct: 617 CSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHS 676

Query: 643 PGQEGAAA----PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAP 698
           P           P E    C     P+ S     GS       ASG   P S G   S  
Sbjct: 677 PLDSSVTKQVPRPPERRRACQDGSVPRYS-----GSSSSTRTQASGNLRPPSSGSLPSQD 731

Query: 699 SRKTESPSLGKVVPLSLEK-----TKPSSS------SRQLDRKAL------GSARSPEGA 741
              T S ++   V             PS+       SR      +        ++S   +
Sbjct: 732 LLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAAS 791

Query: 742 RGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWE 801
            G E R  P+    SS     +G+ +  A G  RS C       PG +      + PS E
Sbjct: 792 LGEEARDTPQP---SSPLVLQVGRPEQGAVGPHRSHC----CSQPGTQPAQEAQRGPSPE 844

Query: 802 AS------APPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSP---- 851
           AS       P PPR     Q  + +C S   S  S   G GGS    Q   R P P    
Sbjct: 845 ASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSP---QEGTRQPGPTPSP 901

Query: 852 -----PSRRDAGLQ--VSLGAAETRSVAT--GPMTPQAAA-------PPAFPEVRVR 892
                 SRR +  Q   S G +E +++ +  GP   + A+       P + PE  VR
Sbjct: 902 GPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVR 958



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 149/711 (20%), Positives = 216/711 (30%), Gaps = 120/711 (16%)

Query: 19   PPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHT-----------PDQSPGM 67
            P G  P +  CP+    G  S++      +++KA  +                P+Q   +
Sbjct: 462  PEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRL 521

Query: 68   ESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS-----GTPE 122
              R RS  GA   +S S G        S     PQ  P K   E      S      +P 
Sbjct: 522  TPRARSEEGASSDSSASTGSHEG---SSEWGGRPQGCPGKARAETSQQEASEGGDPASPA 578

Query: 123  ATTSGKPEPVSSVKTEPKSSDD-------RNPMFLEKMDFKSSKQADST-SIGKEDPGSS 174
             + S         +T+ + ++        R P+ L       S+ A ST S         
Sbjct: 579  LSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQ 638

Query: 175  RKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKED 234
            R+     +  + P   G G     G       RK+         PL SS T  V PR   
Sbjct: 639  RRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHS------PLDSSVTKQV-PR--- 688

Query: 235  PGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPS 294
            P   R+     S            PRYSG      ++              SG   P  S
Sbjct: 689  PPERRRACQDGS-----------VPRYSGSSSSTRTQA-------------SGNLRPPSS 724

Query: 295  GKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMAD 354
            G    +P + +   S+    P +    + G S  N P +   G  GS      TC     
Sbjct: 725  GS---LPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSR-----TC----S 772

Query: 355  PASVGNVETVPATKEDSRFLGK--------MDPASSGEGRPVSG-------HTDTTASAK 399
            PA +    +   +K  +  LG+          P     GRP  G       H  +    +
Sbjct: 773  PAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQ 832

Query: 400  TDLTSLKNVDPMSS---GKVDPVS-LGKMDPM----------CSGKPELLSPGQAERVSV 445
                + +   P +S   G+  P    G+  P            S +     PG + +   
Sbjct: 833  PAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGT 892

Query: 446  GKAG-TVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAG 504
             + G T SPG     S R      AGSR  S EK      G      +    P SL  + 
Sbjct: 893  RQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSS 952

Query: 505  PPSAVKAEPATGGKGDP------LSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKG- 557
            P + V+ E       +P      L+ E  G    G   P      +    G  +P   G 
Sbjct: 953  PEAVVR-EWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQ 1011

Query: 558  ---KADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVD------PVSLGKAEAIPEGKVGS 608
               + D G   + +   +G   + P     VP G         P   G     P G   S
Sbjct: 1012 QSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVS 1071

Query: 609  LPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCL 659
            L    G    +T+      G  Q +     E   P     +    A   CL
Sbjct: 1072 LRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCL 1122



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 99/456 (21%), Positives = 152/456 (33%), Gaps = 56/456 (12%)

Query: 526  KAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVST--PGKTV 583
            K G    G+AA  A GK         DP S         G G  +S G  V     G+  
Sbjct: 1696 KRGEHTDGEAAEVAPGKTHT------DPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGS 1749

Query: 584  PVPSGKVDPVSLGKAEAIP-----EGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKA 638
               +   DP  LG+AE        EGK  +     GS +          G+A+ +  G +
Sbjct: 1750 QRLNRDKDP-KLGEAEGDAMAQEREGKTHNSETSAGSEL----------GEAEQEGEGIS 1798

Query: 639  ETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAE----PLASGKGEPVSLG-- 692
            E    G +G+          L+ E     ++ DPG    AE    P A G+ +P S G  
Sbjct: 1799 ERGETGGQGSGHEDN-----LQGEAAAGGDQ-DPGQSDGAEGIEAPEAEGEAQPESEGVE 1852

Query: 693  ----KADSAPSRKTESPSLGKV-VPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGR 747
                + D+  +     P    V  P +  + +P S   +            EGA   E  
Sbjct: 1853 APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912

Query: 748  VEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPP 807
             E + E  S     + G+ + E+ GAE     EAA    G          P  E      
Sbjct: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEG-------QTQPESEVIESQE 1965

Query: 808  PREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAE 867
              E+A  ++     + V V     +  A   +   + AP A       +   Q      E
Sbjct: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE-APEAEGEMQEAEEEAQPESDGVE 2024

Query: 868  TRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGA 927
             +  + G    +        E   +P S     V  PE  E  ++   + +    E +  
Sbjct: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPES---DGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081

Query: 928  AMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARA 963
            + +V+    A +   E Q E  G +   A   A +A
Sbjct: 2082 SEDVD----AQEAEGEAQPESEGVEAPEAEGEAQKA 2113



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 30/108 (27%), Positives = 39/108 (36%), Gaps = 7/108 (6%)

Query: 18  SPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGA 77
           S PG +P      Q G     S     YCP+  +  P P R +   S G        +  
Sbjct: 827 SQPGTQPAQE--AQRGPSPEASWLCGRYCPTPPRGRPCPQRRS--SSCGSTGSSHQSTAR 882

Query: 78  GEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATT 125
           G G S  +G R     PSP    P    S+ +  + GA   G  E  T
Sbjct: 883 GPGGSPQEGTRQPGPTPSP---GPNSGASRRSSASQGAGSRGLSEEKT 927



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 167/812 (20%), Positives = 268/812 (33%), Gaps = 146/812 (17%)

Query: 17   SSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQ---------QKASPAPPRHTPDQSPGM 67
            S  P P  T+  C + G+   G  A     PS          ++ +  P R      PG 
Sbjct: 772  SPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGT 831

Query: 68   ESRHRSPSGAGEGASCSDGPRGSLACPSPT----CFSPQESPSKETLEAHGASISGTPEA 123
            +    +  G    AS   G      CP+P     C   + S    T  +H ++  G   +
Sbjct: 832  QPAQEAQRGPSPEASWLCGRY----CPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGS 887

Query: 124  TTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTG 183
               G  +P  +    P S   R          +SS    + S G  +  + R       G
Sbjct: 888  PQEGTRQPGPTPSPGPNSGASR----------RSSASQGAGSRGLSEEKTLRSGG----G 933

Query: 184  KAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLR--KV 241
                E      P +  R  P  V +E L ++ + +P+  +            G LR  +V
Sbjct: 934  PQGQEEASGVSPSSLPRSSPEAVVREWLDNIPE-EPILMTYELADETTGAAGGGLRGPEV 992

Query: 242  DPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGP-SGKADPM 300
            DP     ++ +     EP  +G++    S +  P    + +  L G  D GP SG+  P 
Sbjct: 993  DPGDDHSLEGL----GEPAQAGQQ----SLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQ 1044

Query: 301  PL------ESMDSASTGKTEPG--------LLGKLIPGSSGKNGPVSSGTGAPGSLGRLD 346
                    E+   A   +  P         L G++   +      + S  G P S+  + 
Sbjct: 1045 GAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVS 1104

Query: 347  P--------------TCLG--------MADPASVGNVETVPATKEDSRFLGKMDPASS-G 383
                           TCL         +  PAS    +  P  +E       + P    G
Sbjct: 1105 RPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVG 1164

Query: 384  EGRPVSGHTDTTAS-AKTDLTS---LKNVDPMSSGKVDPVS----LGKMDPMCSGKPELL 435
            E +  SG  + T S A  DL S    +N  P SS  VD  S     G+    C+    L+
Sbjct: 1165 EDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLV 1224

Query: 436  SPGQAERVSVGKAGTVSPGKEDPVSSRRED----PISAGSRKTSSEKVNPESSGKTNPVS 491
            + G    +        S   E P     +     P    +R  +    N + + + +   
Sbjct: 1225 TQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACA-TNEDEAERDSEEQ 1283

Query: 492  SGPGDPRSLGTAGPPSAVKAEPATGG-KGDPLSSEKAGLVASGKAAPTASGKAEPLAVGK 550
                +   L        V+ E    G +G+ L  E   L    +   T  G  E     +
Sbjct: 1284 RASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQL----EETKTEEGLQEEGVQLE 1339

Query: 551  EDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLP 610
            E   ++G+       Q +   + ++  T G+ +     +++ V  G     PEG +    
Sbjct: 1340 ETKETEGEGQ-----QEEEAQLEEIEETGGEGLQEEGVQLEEVKEG-----PEGGLQGEA 1389

Query: 611  LEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKV 670
            LE+G                  + G   E  + GQE + A    G         + S++ 
Sbjct: 1390 LEEGLK----------------EEGLPEEGSVHGQELSEASSPDG---------KGSQED 1424

Query: 671  DPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRK 730
            DP    +A   AS   EP         P+  TE P+     P  L +T PS+S RQ   +
Sbjct: 1425 DPVQEEEAGR-ASASAEP--------CPAEGTEEPT---EPPSHLSETDPSASERQSGSQ 1472

Query: 731  ALGSARSPEGARGSEGRVEPKAEPVSSTEASS 762
                   P GA    G+   +A+P       S
Sbjct: 1473 LEPGLEKPPGAT-MMGQEHTQAQPTQGAAERS 1503



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 20/111 (18%)

Query: 34   SLGAGSSAMRDYCPSQQKASPAPP-RHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLA 92
            SLG G S       + + +SP P  R TP  SPG ++ H+ P           GP  S A
Sbjct: 2256 SLGDGQSE-----EASESSSPVPEDRPTPPPSPGGDTPHQRPGS-------QTGPSSSRA 2303

Query: 93   CPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPV-SSVKTEPKSS 142
                 C+       K++   H    + +P+A ++G P     + +  P+SS
Sbjct: 2304 SSWGNCW------QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESS 2348


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 184/761 (24%), Positives = 245/761 (32%), Gaps = 136/761 (17%)

Query: 266  HPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGS 325
            +P    +  PT A   +     + + GP G   P+    +  A      PG  G    GS
Sbjct: 382  NPGMKGEAGPTGARGPEGPQGQRGETGPPG---PVGSPGLPGAIGTDGTPGAKGPT--GS 436

Query: 326  SGKNGPVSSG--TGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSG 383
             G +GP  S    G+PG  G   P  +    P   G    VP  K ++   G  +P   G
Sbjct: 437  PGTSGPPGSAGPPGSPGPQGSTGPQGI-RGQPGDPG----VPGFKGEAGPKG--EPGPHG 489

Query: 384  EGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSL-----GKMDPMCSGKPELLSPG 438
               P+    +               DP + G   PV        +  P   G P      
Sbjct: 490  IQGPIGPPGEEGKRGPRG-------DPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKG-A 541

Query: 439  QAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSG----- 493
            Q ER  VG +G     + DP   R  +P   G+R  +         GK  P+ +      
Sbjct: 542  QGERGPVGSSGPKG-SQGDP--GRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGR 598

Query: 494  PGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGL--VASGKAAPTASGKAEPLAVGKE 551
            PG P S+G  G P ++      G  GDP    +AG   V   + AP   G+  P      
Sbjct: 599  PGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGP 658

Query: 552  DPVSKGKADAGPSGQGDSVSIGKVVSTPG-------KTVPVPSGKVDPVSLGKAEAIPEG 604
              ++  + + GP G      +      PG       + VP   G V P+        P G
Sbjct: 659  PGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGDPGAVGPLG-------PRG 711

Query: 605  KVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETP 664
            + G+ P E+G P  T     +         G K     PG  G   PG+ G   L+    
Sbjct: 712  ERGN-PGERGEPGITGLPGEKGMAGGHGPDGPKGS---PGPSG--TPGDTGPPGLQGMPG 765

Query: 665  QASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSS 724
            +      PG   K +    G GE  + G A +  +R    P LG   P      K     
Sbjct: 766  ERGIAGTPGP--KGD--RGGIGEKGAEGTAGNDGARGLPGP-LGPPGPAGPTGEKGEPGP 820

Query: 725  RQL-----DRKALGS--ARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSP 777
            R L      R   GS     P GA G  G   P  +P    E    GQK     G   SP
Sbjct: 821  RGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQK-----GDAGSP 875

Query: 778  CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGG 837
             P+  A  PGP   +          +  PP        AG        V P  P  GA G
Sbjct: 876  GPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAG-------RVGPPGPA-GAPG 927

Query: 838  SAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG-SA 896
             A       +   P  R D G    +G         GP     A PP  P  +  PG   
Sbjct: 928  PAGPLGEPGKEGPPGLRGDPGSHGRVG-------DRGP-----AGPPGGPGDKGDPGEDG 975

Query: 897  LAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPA 956
                  PP PA                  G   +  ++GM  Q+       E G  G P 
Sbjct: 976  QPGPDGPPGPA------------------GTTGQRGIVGMPGQR------GERGMPGLPG 1011

Query: 957  P-----------------PPAARAGPGRSGSVRTAPPDGAA 980
            P                 PP     PG +G V    P+G A
Sbjct: 1012 PAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPA 1052



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 180/725 (24%), Positives = 245/725 (33%), Gaps = 166/725 (22%)

Query: 290 DPGPSGKADPMPLESMDSASTGKTEPGLLG-KLIPGSSGKNGPVSSGTGAPGSLGRLDPT 348
           +PG +G    +       A      PGL G K   G  G  GP     GAPGS G   PT
Sbjct: 268 EPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGE-VGAPGSKGEAGPT 326

Query: 349 C-LGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKN 407
             +G   P         P      R  G++ P  +   R   G                 
Sbjct: 327 GPMGAMGPLG-------PRGMPGER--GRLGPQGAPGQRGAHGM---------------- 361

Query: 408 VDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAG-TVSPGKEDPVSSRREDP 466
             P   G + P+ +    P  SG P   +PG       G+AG T + G E P   R E  
Sbjct: 362 --PGKPGPMGPLGI----PGSSGFPG--NPGMK-----GEAGPTGARGPEGPQGQRGE-- 406

Query: 467 ISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEK 526
                            +G   PV S PG P ++GT G P A     + G  G P S+  
Sbjct: 407 -----------------TGPPGPVGS-PGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAGP 448

Query: 527 AGLVASGKAAPTASGKAEPLAVGKE--DPVSKG-KADAGPSGQGDSVSIGKVVSTPGKT- 582
            G       +P   G   P  +  +  DP   G K +AGP G+     I   +  PG+  
Sbjct: 449 PG-------SPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEG 501

Query: 583 VPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKL 642
              P G  DP ++G     P G VG    E+G+P            +  P S G     L
Sbjct: 502 KRGPRG--DPGTVG-----PPGPVG----ERGAP----------GNRGFPGSDG-----L 535

Query: 643 PGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKT 702
           PG +G  A GE G V      P+ S+  DPG  R  EP     G P + G   +   +  
Sbjct: 536 PGPKG--AQGERGPV--GSSGPKGSQG-DPG--RPGEP-----GLPGARGLTGNPGVQGP 583

Query: 703 ESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASS 762
           E    GK+ PL      P    R     ++G  R   G+ G  G      +P    EA +
Sbjct: 584 E----GKLGPLG----APGEDGRPGPPGSIG-IRGQPGSMGLPGPKGSSGDPGKPGEAGN 634

Query: 763 LGQKDLEAA-GAERSPCPEAAAPPP---GPRTRDNFTKAPSWEASAPPPPREDAGTQAGA 818
            G      A G +    P     PP   G R          ++    PP     G + G 
Sbjct: 635 AGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGD 694

Query: 819 QACVS--VAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPM 876
           Q       AV P+ P+   G             +P  R + G+   L   +  +   GP 
Sbjct: 695 QGVPGDPGAVGPLGPRGERG-------------NPGERGEPGI-TGLPGEKGMAGGHGPD 740

Query: 877 TPQAAAPPAF-------PEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAM 929
            P+ +  P+        P ++  PG    A    P+           EKG      G A 
Sbjct: 741 GPKGSPGPSGTPGDTGPPGLQGMPGERGIAGTPGPKGDRG----GIGEKG----AEGTAG 792

Query: 930 EVEVLGMAIQKHLERQIEEHGRQGAPAP-----PPAARAGPGR------SGSVRTAPPDG 978
                G+             G +G P P     PP +R  PG       +G+V  A P G
Sbjct: 793 NDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQG 852

Query: 979 AAKRP 983
              +P
Sbjct: 853 PDGQP 857



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 133/522 (25%), Positives = 163/522 (31%), Gaps = 135/522 (25%)

Query: 288  KRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDP 347
            K +PGP G   P               PG  G   PGS G+NGP    TGA G  G   P
Sbjct: 815  KGEPGPRGLVGP---------------PGSRGN--PGSRGENGP----TGAVGFAGPQGP 853

Query: 348  TCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKN 407
                   P   G     P  K D+   G    A S      +G         T       
Sbjct: 854  D----GQPGVKGE-PGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGAT 908

Query: 408  VDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTV-SPGKEDPVSSRRE-- 464
              P S+G+V P       P  +G P             G AG +  PGKE P   R +  
Sbjct: 909  GFPGSAGRVGP-------PGPAGAP-------------GPAGPLGEPGKEGPPGLRGDPG 948

Query: 465  ------DPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGK 518
                  D   AG      +K +P   G+  P     G P   GT G    V      G +
Sbjct: 949  SHGRVGDRGPAGPPGGPGDKGDPGEDGQPGP----DGPPGPAGTTGQRGIVGMPGQRGER 1004

Query: 519  GDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVST 578
            G P     AG    GK  PT +                   D GP G          V  
Sbjct: 1005 GMPGLPGPAG--TPGKVGPTGA-----------------TGDKGPPGP---------VGP 1036

Query: 579  PGKTVPVPSGKVDPVSLGKAEAIP--EGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGG 636
            PG   PV  G+  P      +  P  +G VG    E+G      + DP  +G        
Sbjct: 1037 PGSNGPV--GEPGPEGPAGNDGTPGRDGAVG----ERGD-----RGDPGPAG-------- 1077

Query: 637  KAETKLPGQEGA-AAPGEAGAVCLKKETPQASEKVDPGSCRKAEP--LASGKGEPVSLG- 692
                 LPG +GA   PG  GA         A ++ DPGS     P   A  +G P   G 
Sbjct: 1078 -----LPGSQGAPGTPGPVGA------PGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGP 1126

Query: 693  ---KADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSA--RSPEGARGSEGR 747
               K D                 L      P  +  Q      GSA    P G RG  G 
Sbjct: 1127 RGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQ------GSAGIPGPFGPRGPPGP 1180

Query: 748  VEPKAEPVSSTEASSLGQKDLEAAGAERSP-CPEAAAPPPGP 788
            V P  +  +      +G   +  +  E  P  P     PPGP
Sbjct: 1181 VGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGP 1222



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 173/730 (23%), Positives = 230/730 (31%), Gaps = 117/730 (16%)

Query: 20   PGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGE 79
            PGP  +     Q GS+G          P  + +S  P +     + G+  +  +P   GE
Sbjct: 599  PGPPGSIGIRGQPGSMGL---------PGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGE 649

Query: 80   -GASCSDGP------RGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPV 132
             G S   GP      RG    P PT F     P     E       G P     G P  V
Sbjct: 650  VGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVP-----GDPGAV 704

Query: 133  SSV--KTEPKSSDDRNPMFLEKMDFKSSKQADSTSIG-KEDPGSSRKADPMFTGK----- 184
              +  + E  +  +R    +  +  +          G K  PG S    P  TG      
Sbjct: 705  GPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPS--GTPGDTGPPGLQG 762

Query: 185  --AEPEILG----KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL 238
               E  I G    KGD    G          D G+ G   PL        +  K +PG  
Sbjct: 763  MPGERGIAGTPGPKGDRGGIGEKGAEGTAGND-GARGLPGPLGPPGPAGPTGEKGEPGPR 821

Query: 239  RKVDPVSSDKVDPVFPRKEEPR----YSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPS 294
              V P  S + +P    +  P     ++G + P     V     E      +G   PGP 
Sbjct: 822  GLVGPPGS-RGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGS--PGPQ 878

Query: 295  GKAD------PMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRL-DP 347
            G A       P  +  +      +  PG  G   PGS+G+ GP     GAPG  G L +P
Sbjct: 879  GLAGSPGPHGPNGVPGLKGGRGTQGPPGATG--FPGSAGRVGPPGPA-GAPGPAGPLGEP 935

Query: 348  TCLG----MADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLT 403
               G      DP S G V              K DP   G+  P         + +  + 
Sbjct: 936  GKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIV 995

Query: 404  SLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSP-GKEDPVSSR 462
             +    P   G+     L    P  +G P  + P  A     G  G V P G   PV   
Sbjct: 996  GM----PGQRGERGMPGL----PGPAGTPGKVGPTGATG-DKGPPGPVGPPGSNGPVGEP 1046

Query: 463  REDPISAGSRKTSSEKVNPESSGKTNPVSSGP-GDPRSLGTAGPPSAVKAEPATGGKGDP 521
              +  +        +    E   + +P   GP G P S G  G P  V A    G +GDP
Sbjct: 1047 GPEGPAGNDGTPGRDGAVGERGDRGDP---GPAGLPGSQGAPGTPGPVGAPGDAGQRGDP 1103

Query: 522  LSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKG----------------KADAGPSG 565
             S    G    G+A        +     K D   +G                    GP+G
Sbjct: 1104 GSRGPIG--PPGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNG 1161

Query: 566  QGDSVSIGKVVSTPGKTVPV-PSGKV-DPVSLGK----------AEAIPEGKVGSLPLEK 613
            +  S  I       G   PV PSGK  +P  LG            EA PEG  G    E 
Sbjct: 1162 EQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPG----EP 1217

Query: 614  GSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPG 673
            G P       P   G      G      + G    + P         +  P    K DPG
Sbjct: 1218 GPP-----GPPGPPGHLTAALG-----DIMGHYDESMPDPLPEFTEDQAAPDDKNKTDPG 1267

Query: 674  SCRKAEPLAS 683
                 + L+S
Sbjct: 1268 VHATLKSLSS 1277



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 128/535 (23%), Positives = 162/535 (30%), Gaps = 116/535 (21%)

Query: 453 PGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAE 512
           PG+  PV S+     + G   T+  +      G+   V    G     G AGPP +    
Sbjct: 89  PGECCPVCSQ-----TPGGGNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPR 143

Query: 513 PATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSI 572
              G KG P                   G   P  +  E  V       GP G       
Sbjct: 144 GERGPKGRP-------------------GPRGPQGIDGEPGVPGQPGAPGPPGHP----- 179

Query: 573 GKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKG-SPVTTTKADPRASGKAQ 631
               S PG     P G   P S   A    +  +GS   + G  P +     PR     Q
Sbjct: 180 ----SHPG-----PDGLSRPFSAQMAGLDEKSGLGS---QVGLMPGSVGPVGPRGPQGLQ 227

Query: 632 PQSGGKAETKLPGQEGAAAP-GEAGAVCLKKETPQASEKVDPGSCRKAEPLASG-KGEPV 689
            Q GG   T  PG+ G   P G  G+   +    +  E  +PG  R   P   G  G P 
Sbjct: 228 GQQGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEPG--RNGNPGEVGFAGSPG 285

Query: 690 SLG--KADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGS--ARSPEGARGSE 745
           + G   A   P  K      G   P   E   P S         +G+     P G  G  
Sbjct: 286 ARGFPGAPGLPGLKGHRGHKGLEGPKG-EVGAPGSKGEAGPTGPMGAMGPLGPRGMPGER 344

Query: 746 GRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAP 805
           GR+ P+  P         GQ+     GA   P       P G      F   P  +  A 
Sbjct: 345 GRLGPQGAP---------GQR-----GAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAG 390

Query: 806 PPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAP--SPPSRRDAGLQVSL 863
           P          GA+        P  PQ   G      +  P  P  SP      GL  ++
Sbjct: 391 P---------TGAR-------GPEGPQGQRG------ETGPPGPVGSP------GLPGAI 422

Query: 864 GAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWE 923
           G            TP A  P   P     PGSA         P  P    S   +G    
Sbjct: 423 GT---------DGTPGAKGPTGSPGTSGPPGSA-------GPPGSPGPQGSTGPQG---- 462

Query: 924 VYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDG 978
           + G   +  V G   +   + +   HG QG P  PP      G  G   T  P G
Sbjct: 463 IRGQPGDPGVPGFKGEAGPKGEPGPHGIQG-PIGPPGEEGKRGPRGDPGTVGPPG 516


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
            region 1 [Homo sapiens]
          Length = 1400

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 134/651 (20%), Positives = 220/651 (33%), Gaps = 85/651 (13%)

Query: 254  PRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKT 313
            P   EP   G+  P +++K   +SAE  +    G+R P  +    P P E  ++      
Sbjct: 456  PSPAEPTEHGERTPFANDKTTSSSAESTE---HGERTPLANENTTPSPAEPTENRERTAN 512

Query: 314  EPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKE---- 369
            E        P  +G      +      +L  ++PT     +  +  N +T P+  E    
Sbjct: 513  E-----NTTPSPAGPTENRETTANEKTTLSPVEPT----ENRETTANEKTTPSPAEPTEN 563

Query: 370  --------DSRFLGKMDPASSGEGRPVSGHTDTTASAK-TDLTSLKNVDPMSSGKVDPVS 420
                    +       +P   GE  P++    T + A+ T+       +  +    +P  
Sbjct: 564  GQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTE 623

Query: 421  LGKMDPMCSGK--PELLSPGQ-AERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTS-- 475
             G   P+ + K  P L  P +  +R       T S   E P       P++  +   S  
Sbjct: 624  NGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAE-PTEHEERTPLANENTTPSPA 682

Query: 476  --SEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASG 533
              +E     ++  T P  +GP + R +      +   AEP          +E     A+ 
Sbjct: 683  EPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEP----------TENRERTANE 732

Query: 534  KAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPV 593
            K   T S  AEP   G+  P +  K                  +T     P   G+  P+
Sbjct: 733  K---TTSSPAEPTENGQRTPFANEK------------------TTSSSAEPTEHGERTPL 771

Query: 594  SLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGE 653
            +       P G   +         T   A+P  +   + ++  +  T  P Q     P E
Sbjct: 772  ANENTTLSPAGPTENRERTANEKTTPFPAEPTEN---RERTANENTTPSPAQ-----PTE 823

Query: 654  AGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPL 713
             G       TP A+EK  P     AEP  +GK  P +  K  S+ +  TE     +  PL
Sbjct: 824  NG-----DRTPLANEKTTPSL---AEPTENGKRTPFANEKTTSSSAEPTEH---AERTPL 872

Query: 714  SLEKTKPSSSSRQLDRKALGSARSPE-GARGSEGRVEPKAEPVSSTEASSLGQKDLEA-A 771
            + E T  S +    +R+   + ++ +  A  +E R     E  +   A     ++  A  
Sbjct: 873  ANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANE 932

Query: 772  GAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSP 831
                SP          P   D   +AP  + S    P++   T A      S   S +  
Sbjct: 933  NTTLSPAEPTEHEEMTPLMVDENLQAPFRQGSCAERPKDICATVASTTGSESSTASEIIT 992

Query: 832  QDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAA 882
                  SA +   A    S  +   A + VS  A ET   +T    P  A+
Sbjct: 993  SSTMSVSATASSTASSTASEITMSSAAIPVSSTAYETIRFSTAVSEPVTAS 1043



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 157/834 (18%), Positives = 274/834 (32%), Gaps = 91/834 (10%)

Query: 104  SPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADS 163
            +PS      HG       + TTS   E     +  P ++++  P   E  + +     ++
Sbjct: 455  TPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANEN 514

Query: 164  TSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSS 223
            T+     P  +R+     T   E   L    PV P      T  ++              
Sbjct: 515  TTPSPAGPTENRE-----TTANEKTTL---SPVEPTENRETTANEK-------------- 552

Query: 224  KTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDL 283
                 +P   +P    +  P +++K         EP   G+  P+++E   P+ AE  + 
Sbjct: 553  ----TTPSPAEPTENGQRTPFANEKTT---SSSAEPTEHGERTPLANENTTPSPAEPTE- 604

Query: 284  VLSGKRDPGPSGKADPMPLESMDSA-----STGKTEPGLLGKLIPGSSGKNGPVSSGTGA 338
                 R+   + K  P P E  ++      +  KT P L     P  +G+  P ++    
Sbjct: 605  ----NRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAE---PTENGQRTPFANEKTT 657

Query: 339  PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASA 398
              S    +PT      P +  N    PA   ++R     +  +     P   + + TA+ 
Sbjct: 658  SSS---AEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTE-NREMTANE 713

Query: 399  KTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP 458
            KT L   +  +       +  +    +P  +G+    +P   E+ +   A     G+  P
Sbjct: 714  KTTLFPAEPTENRERTANEKTTSSPAEPTENGQ---RTPFANEKTTSSSAEPTEHGERTP 770

Query: 459  VSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGK 518
            +++       AG  +      N     KT P  + P + R        +   A+P   G 
Sbjct: 771  LANENTTLSPAGPTENRERTANE----KTTPFPAEPTENRERTANENTTPSPAQPTENGD 826

Query: 519  GDPLSSEK-----AGLVASGKAAP-----TASGKAEPLAVGKEDPVSKGKADAGPSGQGD 568
              PL++EK     A    +GK  P     T S  AEP    +  P++     + P+   +
Sbjct: 827  RTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLANENTTSSPAEPTE 886

Query: 569  SVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASG 628
            +    +  +   KT   P+   +       E+    K    P E       T  +     
Sbjct: 887  N----RERTANEKTTQFPAEPTE-----NRESTANEKTTPFPAEPTENREWTANENTTLS 937

Query: 629  KAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGS-CRKAEPLASGKGE 687
             A+P +  +  T L   E   AP   G+   + +   A+     GS    A  + +    
Sbjct: 938  PAEP-TEHEEMTPLMVDENLQAPFRQGSCAERPKDICATVASTTGSESSTASEIITSSTM 996

Query: 688  PVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARG---- 743
             VS   + +A S  +E       +P+S    +    S  +      S  + E        
Sbjct: 997  SVSATASSTASSTASEITMSSAAIPVSSTAYETIRFSTAVSEPVTASILALESTLAFTTV 1056

Query: 744  SEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWE-- 801
            S          V +T AS+ G K+  A  A  S    AA       T    T   + E  
Sbjct: 1057 SNTTTSSTVTSVPTT-ASTSGSKNTTACEATMSETTIAAITASEDTTVSTQTSVIAAESV 1115

Query: 802  ---ASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAG 858
               A+  P     A   A      +++V   +P      ++ +   A +  +  +     
Sbjct: 1116 PHTATKTPTDTTTASVSATVPKNNTLSVITSTPSTAPNTASKTMTTASKTTTTSTITSLP 1175

Query: 859  LQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSAL----AAAVAPPEPAE 908
              V      T  +  G   P A+   +         S      A + APP PAE
Sbjct: 1176 TTV---FTTTSKITAGSEIPTASTTDSATTAISTKASGTTVESAPSTAPPTPAE 1226



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 166/901 (18%), Positives = 293/901 (32%), Gaps = 125/901 (13%)

Query: 53   SPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPT-----CFSPQESPSK 107
            SPA P    +++   E+   SP+G  E    +   + +L+   PT       + + +PS 
Sbjct: 499  SPAEPTENRERTAN-ENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSP 557

Query: 108  ETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIG 167
                 +G       E TTS   EP    +  P ++++  P   E  + +     + T+  
Sbjct: 558  AEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPS 617

Query: 168  KEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVD-----PLCS 222
              +P  +    P+   K  P +    +P   G+  P    K    S    +     PL +
Sbjct: 618  PAEPTENGDRTPLANEKTTPSL---AEPTENGQRTPFANEKTTSSSAEPTEHEERTPLAN 674

Query: 223  SKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPV----SSEKVAPTSA 278
              T   +P   +P   R+     +    P  P +     + ++  +     +E    T+ 
Sbjct: 675  ENT---TPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTAN 731

Query: 279  EKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGA 338
            EK     S   +P  +G+  P   E   S+S   TE G    L    + +N  +S     
Sbjct: 732  EK---TTSSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPL----ANENTTLSPA--- 781

Query: 339  PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASA 398
             G     + T      P      E    T  ++       P  +G+  P++    T + A
Sbjct: 782  -GPTENRERTANEKTTPFPAEPTENRERTANENTTPSPAQPTENGDRTPLANEKTTPSLA 840

Query: 399  KTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDP 458
                      +P  +GK  P +  K     +   E      AER  +    T S   E P
Sbjct: 841  ----------EPTENGKRTPFANEKTTSSSAEPTE-----HAERTPLANENTTSSPAE-P 884

Query: 459  VSSRREDPISAGSRKTSSEKVNPESSG--KTNPVSSGPGDPRSLGTAGPPSAVKAEPATG 516
              +R        ++  +    N ES+   KT P  + P + R        +   AEP   
Sbjct: 885  TENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEH 944

Query: 517  GKGDPLSSEKAGLVASGKAAPTASGKAEPLA-----VGKE-----DPVSKGKADAGPSGQ 566
             +  PL  ++  L A  +    A    +  A      G E     + ++        +  
Sbjct: 945  EEMTPLMVDE-NLQAPFRQGSCAERPKDICATVASTTGSESSTASEIITSSTMSVSATAS 1003

Query: 567  GDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPV-----TTTK 621
              + S    ++     +PV S   + +    A + P      L LE          TTT 
Sbjct: 1004 STASSTASEITMSSAAIPVSSTAYETIRFSTAVSEPV-TASILALESTLAFTTVSNTTTS 1062

Query: 622  ADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPL 681
            +   +       SG K  T     E   +     A+   ++T  +++             
Sbjct: 1063 STVTSVPTTASTSGSKNTTAC---EATMSETTIAAITASEDTTVSTQ------------- 1106

Query: 682  ASGKGEPVSLGKADSAPSRKTESP------SLGKVVP--------LSLEKTKPSSSSRQL 727
                    S+  A+S P   T++P      S+   VP         S   T P+++S+ +
Sbjct: 1107 -------TSVIAAESVPHTATKTPTDTTTASVSATVPKNNTLSVITSTPSTAPNTASKTM 1159

Query: 728  DRKALGSARS-----PEGARGSEGRVEPKAE-PVSSTEASSLGQKDLEAAGAERSPCPEA 781
               +  +  S     P     +  ++   +E P +ST  S+      +A+G      P  
Sbjct: 1160 TTASKTTTTSTITSLPTTVFTTTSKITAGSEIPTASTTDSATTAISTKASGTTVESAPST 1219

Query: 782  AAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFS 841
            A P P   T           AS P           G     SV  +  +    +   + +
Sbjct: 1220 APPTPAETT----------TASVPTTTSTTGSENTGHHTVSSVPTTVFATASESSTGSET 1269

Query: 842  FQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAV 901
             +A+  A    +     +      +ET  V+T    P       F    V P     A+V
Sbjct: 1270 TRASTSATEVTTAMTTAMTT---GSETAVVST--KAPVTTTQSGFSTATVMPAKTTTASV 1324

Query: 902  A 902
            +
Sbjct: 1325 S 1325


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 136/533 (25%), Positives = 193/533 (36%), Gaps = 69/533 (12%)

Query: 431 KPELLSPGQAERVSVGKA-GTVSPGKEDPVSSRREDPIS-----------AGSRKTSSEK 478
           K +    G A R    +A G ++P    P S R   P++           A  RK  +E+
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTP--RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61

Query: 479 VN-------PESSGKTNPVSSGPGDPRSLGTAGPPSA--VKAEPATGGKGDPLSSEKAGL 529
                    PES+ +  P  S     R+  +  P S    +A PA      P+SS     
Sbjct: 62  AGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGR-- 119

Query: 530 VASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGK 589
            ASG   P   G+ + L +  E+ V++GKA   P     S    +  S P    P P+  
Sbjct: 120 -ASGTTRPGPLGQ-KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 177

Query: 590 VDPVSLGKAEAIPEGKVGSLP----------LEKGSPVTTTKADPRASGKAQPQSGGKAE 639
               + G    +P     + P          +   S  +TT+  P A  + +P +GG  +
Sbjct: 178 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA--RRRPSAGGGLQ 235

Query: 640 TKLPGQEGAAA-----PGEAGAVCLKKETPQA----SEKVDPG--SCRKAEPLASGKGEP 688
                   ++A     P  +G     + TP+A    S+    G  + R  +     K   
Sbjct: 236 RPASRSLSSSATPLSSPARSGPSA--RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 293

Query: 689 VSLGKADSAPSRKTESPS--LGKVVPLSLEKTKPSSS-SRQLDRKALGSARSPEGARGSE 745
            +LG   S+P   T SPS  L    P +L  T  SSS + QL      +  SP      +
Sbjct: 294 PALGPLSSSPLA-TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQ 352

Query: 746 GRVEPKAEPVSSTEASSLGQKDLEAAGA--ERSPCPEAAAPPPGPRTR---DNFTKAPSW 800
               P A P S    +SLG   L+A  +     P    A PPP              PS 
Sbjct: 353 TLPSPPATPPSQA-TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP 411

Query: 801 EASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSA-FSFQAAPR---APSPPSRRD 856
            AS P  P      QA     V +  +P SP       A FS  A+P    + +PPS+  
Sbjct: 412 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471

Query: 857 AGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEP 909
             L            A+ PM+P A  PP  P     P   LA    PP  A P
Sbjct: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA---KPPPQAPP 521



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 161/664 (24%), Positives = 220/664 (33%), Gaps = 122/664 (18%)

Query: 285 LSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGT----GAPG 340
           +  KRD   +G A   P             PGLL    PGS     PV+       GA G
Sbjct: 1   MDNKRDKAKAGAAARTP---------AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAG 51

Query: 341 SLGRLDPTCLGMADPASVGNVETVP-----ATKEDSRFLGKMDPASSGEGRPVSGHTDTT 395
           ++GR       +A+ A      T+P     A    S      +PAS     P SG  +  
Sbjct: 52  AVGRKP-----LAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRP---PASGRGERA 103

Query: 396 ASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER------VSVGKAG 449
             AK       +    +SG   P  LG+     S + E ++ G+A        +S G   
Sbjct: 104 PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE-ETVARGKATEAPKRSALSAGARR 162

Query: 450 TVS---PGKEDPVSSRREDPISAGS-----RKTSSEKVNPESSGKTNPVSSGPGDPRSLG 501
             S   PG   P  +RR    +AG+     R   S +  P + G    VSS         
Sbjct: 163 DTSGPTPGTPSPAMARRSR--AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH----S 216

Query: 502 TAGPPSAVKAEPATGG-----KGDPLSSEKAGLVASGKAAPTASG-----------KAEP 545
           T  P  A +  P+ GG         LSS    L +  ++ P+A G           K + 
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG 276

Query: 546 LAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGK 605
           L   +   V+  + DA P+       +G + S+P  T P PS  +   +     A P   
Sbjct: 277 LQALRPPQVTPPRKDAAPA-------LGPLSSSPLAT-PSPSAALQSQAPPTLPATPHSS 328

Query: 606 VGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQ 665
             SL  +  +P+      P A    Q          LP     A P       L   T Q
Sbjct: 329 --SLTCQLATPLPLAPPSPSAPPSLQT---------LPSPP--ATPPSQATTSLGSPTLQ 375

Query: 666 ASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSR 725
           A+    P     + PL+     P     A + P  +   PS     PLS   T    +  
Sbjct: 376 ATHSFLP-----SPPLSPLATPPPQAPPALALPPLQAP-PSPPASPPLSPLATPSPQAPN 429

Query: 726 QLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPP 785
            L    L +  SP  +   +    P A P  S  A+   Q     A       P    PP
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA------PPLQVPP 483

Query: 786 PGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAA 845
             P +       P    SA PPP+  A     A         P +P       A +    
Sbjct: 484 SPPAS-------PPMSPSATPPPQ--APPPLAAPPLQLAKPPPQAPP------ALATPPL 528

Query: 846 PRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPE 905
              PSPP+          G A     A+ PM+P A  PP  P V   P       V P  
Sbjct: 529 QALPSPPASFP-------GQAPFSPSASLPMSPLATPPPQAPPVLAAP----LLQVPPSP 577

Query: 906 PAEP 909
           PA P
Sbjct: 578 PASP 581



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 157/714 (21%), Positives = 223/714 (31%), Gaps = 89/714 (12%)

Query: 229 SPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGK 288
           +P    PG L    P S     PV P     R  G    V  + +A  +       + G 
Sbjct: 16  TPAARAPGLLTPRPPGSPRPPPPVTPAAL--RVLGAAGAVGRKPLAERAGG-----IGGA 68

Query: 289 RDPGPSGKADPMPLESMDSASTGKTEP--GLLGKLIPGSSGKNGPVSS-----GTGAPGS 341
             P  + +A P       S +     P  G   +  P  +   GPVSS     GT  PG 
Sbjct: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128

Query: 342 LGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTD 401
           LG+     L ++   +V   +   A K  +         S+G  R  SG T  T S    
Sbjct: 129 LGQKG---LRISAEETVARGKATEAPKRSA--------LSAGARRDTSGPTPGTPSPAMA 177

Query: 402 LTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSS 461
             S          +     +G   P  S +P    P +  R SV  A   S  +  P ++
Sbjct: 178 RRS----------RAAGTEVGLPRPAPSARPR--PPTEGPRKSVSSASEHSTTEPSP-AA 224

Query: 462 RREDPISAGSRKTSSEKVNPESSGKTNPVSSGPG--------------DPRSLGTAGPPS 507
           RR      G ++ +S  ++  ++  ++P  SGP                P+ L    PP 
Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284

Query: 508 AVK----AEPATGG-KGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAG 562
                  A PA G     PL++         +A PT        ++  +       A   
Sbjct: 285 VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPS 344

Query: 563 PSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKA 622
           PS      ++    +TP        G   P        +P   +  L             
Sbjct: 345 PSAPPSLQTLPSPPATPPSQATTSLGS--PTLQATHSFLPSPPLSPLATPPPQAPPALAL 402

Query: 623 DPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKE-TPQASEKVDPGSCRKAEPL 681
            P  +  + P S   +    P  +   AP       L+   +P  S  V       A P 
Sbjct: 403 PPLQAPPSPPASPPLSPLATPSPQ---APNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 459

Query: 682 ASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGA 741
            S    P S      A       PS     P+S   T P  +   L    L  A+ P  A
Sbjct: 460 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519

Query: 742 RGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWE 801
                   P  + + S  AS  GQ     + A     P A  PP  P        AP  +
Sbjct: 520 --PPALATPPLQALPSPPASFPGQAPFSPS-ASLPMSPLATPPPQAPPV----LAAPLLQ 572

Query: 802 ASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRD----- 856
              PP P      QA  +           P     G   +   AP  P PPSR       
Sbjct: 573 V--PPSPPASPTLQAPRRPPTP------GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 624

Query: 857 ----AGLQVSLGAA--ETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPP 904
               AG   S  +   E R   +GP    AA+PP   E+     +A +   APP
Sbjct: 625 GPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPP 678



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 65/268 (24%), Positives = 97/268 (36%), Gaps = 29/268 (10%)

Query: 672 PGSCRKAEPLASGKGEPV-SLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRK 730
           PGS R   P+       + + G     P  +      G  +P S  +  P+ S+    R 
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 731 ALGSARSPEGARG---------SEGRVEPKAEPVSSTEASSLGQKDLEAAGAER------ 775
              ++R P   RG         S G V        +T    LGQK L  +  E       
Sbjct: 90  P--ASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA 147

Query: 776 SPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGA 835
           +  P+ +A   G R RD     P   + A       AGT+ G       A  P  P +G 
Sbjct: 148 TEAPKRSALSAGAR-RDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSA-RPRPPTEGP 205

Query: 836 GGSAFSF-QAAPRAPSPPSRR--DAGLQVSLGAAETRSVATGPMT------PQAAAPPAF 886
             S  S  + +   PSP +RR   AG  +   A+ + S +  P++      P A   P  
Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 887 PEVRVRPGSALAAAVAPPEPAEPVRDVS 914
           P    +P      A+ PP+   P +D +
Sbjct: 266 PAHPSQPKPKGLQALRPPQVTPPRKDAA 293



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 36/137 (26%), Positives = 50/137 (36%), Gaps = 9/137 (6%)

Query: 16  DSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPS 75
           D+S  GPR T    P       G        PS   + P    H+   +   E      S
Sbjct: 595 DTSVSGPRLTLALAP-------GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 647

Query: 76  GAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSV 135
           G   GA+ S  P   LA   P  +S   +P      A GA +   P AT  G  + + ++
Sbjct: 648 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP-WPPATGPGSADGLCTI 706

Query: 136 -KTEPKSSDDRNPMFLE 151
            +TE   S    P  L+
Sbjct: 707 YETEGPESATPAPGALD 723


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 245/1013 (24%), Positives = 331/1013 (32%), Gaps = 185/1013 (18%)

Query: 21   GPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEG 80
            GPR         G  GA  +   D  P  + ++ AP        PG     R P G  +G
Sbjct: 390  GPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGP----RGPPGP-QG 444

Query: 81   ASCSDGPRGSLACPSPTCFSPQESPSKETLEA--HGASISGTPEATTSGKPEP--VSSVK 136
            A+   GP+G    P    F  ++ P  E   A   GA      E     + EP  V  + 
Sbjct: 445  ATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIG 504

Query: 137  TEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPV 196
               +     N  F  +      K A        + G S  A P     A  +    G+P 
Sbjct: 505  PPGERGAPGNRGFPGQDGLAGPKGAPG------ERGPSGLAGPK---GANGDPGRPGEPG 555

Query: 197  APGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRK 256
             PG    +T R  D G  GKV P   +      P    P   R    V        FP  
Sbjct: 556  LPGARG-LTGRPGDAGPQGKVGP-SGAPGEDGRPGPPGPQGARGQPGVMG------FPGP 607

Query: 257  E----EPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGK 312
            +    EP  +G++    +  +     +  +   +G   PGP+G A     +     S  +
Sbjct: 608  KGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP--PGPAGPAGERGEQGAPGPSGFQ 665

Query: 313  TEPGLLGKLIPGSSGKNGP--VSSGTGAPGSLG----------RLDPTCLGMADPASVGN 360
              PG  G   PG  GK G   V    GAPG +G          R  P   G+  P  +  
Sbjct: 666  GLPGPPGP--PGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPG 723

Query: 361  VETVPATKEDSRFLGKMDPASSG----EGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                   K  S   G   P + G    +G P        A  K D   +    P  +   
Sbjct: 724  TPGTDGPKGASGPAG--PPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGK 781

Query: 417  DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            D    G   P+    P   +    E+  VG  G                  SAG+R    
Sbjct: 782  DG-GRGLTGPIGPPGP---AGANGEKGEVGPPGPAG---------------SAGARGAPG 822

Query: 477  EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
            E+      G+T P       P   G AGPP A     A G +G+  + +K    A G   
Sbjct: 823  ER------GETGP-------PGPAGFAGPPGADGQPGAKGEQGE--AGQKGDAGAPGPQG 867

Query: 537  PT-ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKT-------VPVPSG 588
            P+ A G   P   G   P     A   P   G   + G+ V  PG          P PSG
Sbjct: 868  PSGAPGPQGP--TGVTGPKGARGAQGPPGATGFPGAAGR-VGPPGSNGNPGPPGPPGPSG 924

Query: 589  KVDPVSLGKAEAIPEGKVG--------SLPLEKGSPVTTTKADPRASGKAQPQSGGKAET 640
            K  P    + ++ P G+ G          P EKG P     +        Q  +G +   
Sbjct: 925  KDGPKG-ARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIV 983

Query: 641  KLPGQEG----AAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGK--A 694
             LPGQ G       PG +G    K+  P AS    P        L    GEP   G   A
Sbjct: 984  GLPGQRGERGFPGLPGPSGEPG-KQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGA 1042

Query: 695  DSAPSR------KTESPSLGKV----VPLSLEKTKPSS-SSRQLDRKALGS-----ARSP 738
            D  P R      K +    G V     P       P+  + +Q DR   G+        P
Sbjct: 1043 DGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGP 1102

Query: 739  EGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAP 798
             GARG +G   P+ +     EA   G++ L+  G       +    PPGP + D     P
Sbjct: 1103 AGARGIQGPQGPRGD---KGEAGEPGERGLK--GHRGFTGLQGLPGPPGP-SGDQGASGP 1156

Query: 799  SWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAG 858
                + P  PR   G            V P S +DGA G        P    PP  R   
Sbjct: 1157 ----AGPSGPRGPPG-----------PVGP-SGKDGANG-------IPGPIGPPGPRG-- 1191

Query: 859  LQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG---SALAAAVAPPEPAEPVRDVSW 915
                      RS  TGP  P     P  P     PG   SA A      +  +P++ +  
Sbjct: 1192 ----------RSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRA 1241

Query: 916  DEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRS 968
            D+       + A ++      A  K L  QIE      +   P  +R  P R+
Sbjct: 1242 DQAAGGLRQHDAEVD------ATLKSLNNQIE------SIRSPEGSRKNPART 1282



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 152/587 (25%), Positives = 200/587 (34%), Gaps = 86/587 (14%)

Query: 431 KPELLSPG-QAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
           K E  +PG + E  S G+ G+  P     +   R     AG+         P  +G   P
Sbjct: 299 KGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGP 358

Query: 490 VSSG-----PGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLV-ASGKAA----PTA 539
           V        PG P + G AGP  A   E A G +G+P +    G   ASG       P A
Sbjct: 359 VGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGA 418

Query: 540 SGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPG----KTVPVPSGKVDPVSL 595
            G A    +         +   GP G    +        PG    K    P G+  P   
Sbjct: 419 KGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGP 478

Query: 596 GKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQP--QSGGKAETKLPGQEGAA---- 649
             A   P G+ G    ++G+     + +P   G   P  + G       PGQ+G A    
Sbjct: 479 QGAPG-PAGEEG----KRGA-----RGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKG 528

Query: 650 APGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGK 709
           APGE G   L    P+ +   DPG            GEP  L  A     R  ++   GK
Sbjct: 529 APGERGPSGLAG--PKGANG-DPGR----------PGEP-GLPGARGLTGRPGDAGPQGK 574

Query: 710 VVPLSL--EKTKPSSSSRQLDRKALG--SARSPEGARGSEGRVEPKAEPVSSTEASSLGQ 765
           V P     E  +P     Q  R   G      P+GA G  G+   K  P  +     L  
Sbjct: 575 VGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLP-GAPGLRGLPG 633

Query: 766 KDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVA 825
           KD E   A     P   A P G R          ++    PP     G + G Q     A
Sbjct: 634 KDGETGAAG----PPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEA 689

Query: 826 VSP--MSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSV-----ATGPMTP 878
            +P  + P+   G         P     P  +  GLQ   G   T        A+GP  P
Sbjct: 690 GAPGLVGPRGERG--------FPGERGSPGAQ--GLQGPRGLPGTPGTDGPKGASGPAGP 739

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
             A  P  P ++  PG   AA +A P+      DV   EKG      GA  +    G+  
Sbjct: 740 PGAQGP--PGLQGMPGERGAAGIAGPKGDRG--DVG--EKGPE----GAPGKDGGRGLTG 789

Query: 939 QKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPG 985
                     +G +G   PP     GP  S   R AP +     PPG
Sbjct: 790 PIGPPGPAGANGEKGEVGPP-----GPAGSAGARGAPGERGETGPPG 831



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 170/736 (23%), Positives = 231/736 (31%), Gaps = 119/736 (16%)

Query: 291  PGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNG-------PVSSGT------- 336
            PG  G+A P      + A   + EPG  G   PG +G +G       P + G+       
Sbjct: 371  PGAKGEAGPTGARGPEGAQGPRGEPGTPGS--PGPAGASGNPGTDGIPGAKGSAGAPGIA 428

Query: 337  GAPGSLGRLDPT----CLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHT 392
            GAPG  G   P       G   P        +   K +    G+  PA   +G P     
Sbjct: 429  GAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGP-QGAPGPAGE 487

Query: 393  DTTASAKTDLTSLKNVDPMSS-GKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTV 451
            +    A+ +   +  + P    G          D +   K    +PG+      G +G  
Sbjct: 488  EGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKG---APGER-----GPSGLA 539

Query: 452  SPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSS-----GPGDPRSLGTAGPP 506
             P   +    R  +P   G+R  +    +    GK  P  +      PG P   G  G P
Sbjct: 540  GPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQP 599

Query: 507  SAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQ 566
              +      G  G+P  + + GL  +           E  A G   P       AG  G+
Sbjct: 600  GVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPA----GPAGERGE 655

Query: 567  GDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVG-----SLPLEKGSPVTTTK 621
              +         PG   P   G          EA   G VG       P E+GSP     
Sbjct: 656  QGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGL 715

Query: 622  ADPRASGKAQPQSGGKAETKLPGQEGA-------AAPGEAGAVCLKKETPQASEKVDPGS 674
              PR         G K  +   G  GA         PGE GA  +      A  K D G 
Sbjct: 716  QGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGI------AGPKGDRGD 769

Query: 675  CRKAEPL-ASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALG 733
              +  P  A GK     L      P     +   G+V P       P+ S+         
Sbjct: 770  VGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGP-----PGPAGSAGARGAPGER 824

Query: 734  SARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDN 793
                P G  G  G      +P +  E    GQK     G   +P P+  +  PGP+    
Sbjct: 825  GETGPPGPAGFAGPPGADGQPGAKGEQGEAGQK-----GDAGAPGPQGPSGAPGPQGPTG 879

Query: 794  FTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPS 853
             T  P     A  PP        GA      A     P  G+ G+       P  P  PS
Sbjct: 880  VT-GPKGARGAQGPP--------GATGFPGAAGRVGPP--GSNGN-----PGPPGPPGPS 923

Query: 854  RRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG-SALAAAVAPPEPAEPVRD 912
             +D G + + G +     A  P     A PP     +  PG    + A  PP P      
Sbjct: 924  GKD-GPKGARGDSGPPGRAGEPGLQGPAGPPG---EKGEPGDDGPSGAEGPPGP------ 973

Query: 913  VSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAP--PPAARAGPGRSGS 970
                         G A +  ++G+  Q+       E G  G P P   P  +  PG SG 
Sbjct: 974  ------------QGLAGQRGIVGLPGQR------GERGFPGLPGPSGEPGKQGAPGASGD 1015

Query: 971  VRTAPPDGAAKRPPGL 986
                 P G    PPGL
Sbjct: 1016 RGPPGPVG----PPGL 1027



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 150/614 (24%), Positives = 203/614 (33%), Gaps = 98/614 (15%)

Query: 419 VSLGKMDPMC-------SGKP----ELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPI 467
           +  G+  P+C       SG+P    +   PG  + + VG  G   PG + P   +     
Sbjct: 80  IPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDI-VGPKGP--PGPQGPAGEQGP--- 133

Query: 468 SAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKA 527
             G R    EK  P   G+       PG P + G  GPP      P   G G   +++ A
Sbjct: 134 -RGDRGDKGEKGAPGPRGRDGE----PGTPGNPGPPGPPGP----PGPPGLGGNFAAQMA 184

Query: 528 GLV---ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSG-QGDSVSIGKVVSTPGKTV 583
           G     A G       G   P+  G   P     A  GP G QG+    G+    PG + 
Sbjct: 185 GGFDEKAGGAQLGVMQGPMGPM--GPRGPPGPAGAP-GPQGFQGNPGEPGE----PGVSG 237

Query: 584 PV-PSGKVDPVSL--GKAEAIPEGKVGSLPLEKGSPVTT-TKADPRASGKAQPQSGGKAE 639
           P+ P G   P        EA   GK G    E+G P     +  P   G      G K  
Sbjct: 238 PMGPRGPPGPPGKPGDDGEAGKPGKAG----ERGPPGPQGARGFPGTPGLP----GVKGH 289

Query: 640 TKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCR-KAEPLASGKGEPVSLGKADSAP 698
              PG +GA   GEAGA  +K E+    E   PG    +  P   G+  P     A    
Sbjct: 290 RGYPGLDGAK--GEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGND 347

Query: 699 SRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSST 758
            +   +   G V P       P +   + +    G AR PEGA+G  G       P  + 
Sbjct: 348 GQPGPAGPPGPVGPAG-GPGFPGAPGAKGEAGPTG-ARGPEGAQGPRGEPGTPGSPGPAG 405

Query: 759 EASSLGQKDLEAA----------------GAERSPCPEAAAPPPGPRTRDNFT------- 795
            + + G   +  A                G    P P+ A  P GP+ +           
Sbjct: 406 ASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKG 465

Query: 796 -------KAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRA 848
                    P+    AP P  E+    A  +      + P   +   G   F  Q     
Sbjct: 466 EQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAG 525

Query: 849 P--SPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEP 906
           P  +P  R  +GL    GA         P  P     P    +  RPG A       P  
Sbjct: 526 PKGAPGERGPSGLAGPKGANGD------PGRPGEPGLPGARGLTGRPGDAGPQGKVGPSG 579

Query: 907 AEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPG 966
           A P  D      G      GA  +  V+G    K    +  + G +G P  P   R  PG
Sbjct: 580 A-PGEDGRPGPPGPQ----GARGQPGVMGFPGPKGANGEPGKAGEKGLPGAP-GLRGLPG 633

Query: 967 RSGSVRTAPPDGAA 980
           + G    A P G A
Sbjct: 634 KDGETGAAGPPGPA 647


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
            sapiens]
          Length = 1418

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 245/1013 (24%), Positives = 331/1013 (32%), Gaps = 185/1013 (18%)

Query: 21   GPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEG 80
            GPR         G  GA  +   D  P  + ++ AP        PG     R P G  +G
Sbjct: 321  GPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGP----RGPPGP-QG 375

Query: 81   ASCSDGPRGSLACPSPTCFSPQESPSKETLEA--HGASISGTPEATTSGKPEP--VSSVK 136
            A+   GP+G    P    F  ++ P  E   A   GA      E     + EP  V  + 
Sbjct: 376  ATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIG 435

Query: 137  TEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPV 196
               +     N  F  +      K A        + G S  A P     A  +    G+P 
Sbjct: 436  PPGERGAPGNRGFPGQDGLAGPKGAPG------ERGPSGLAGPK---GANGDPGRPGEPG 486

Query: 197  APGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRK 256
             PG    +T R  D G  GKV P   +      P    P   R    V        FP  
Sbjct: 487  LPGARG-LTGRPGDAGPQGKVGP-SGAPGEDGRPGPPGPQGARGQPGVMG------FPGP 538

Query: 257  E----EPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGK 312
            +    EP  +G++    +  +     +  +   +G   PGP+G A     +     S  +
Sbjct: 539  KGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP--PGPAGPAGERGEQGAPGPSGFQ 596

Query: 313  TEPGLLGKLIPGSSGKNGP--VSSGTGAPGSLG----------RLDPTCLGMADPASVGN 360
              PG  G   PG  GK G   V    GAPG +G          R  P   G+  P  +  
Sbjct: 597  GLPGPPGP--PGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPG 654

Query: 361  VETVPATKEDSRFLGKMDPASSG----EGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKV 416
                   K  S   G   P + G    +G P        A  K D   +    P  +   
Sbjct: 655  TPGTDGPKGASGPAG--PPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGK 712

Query: 417  DPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSS 476
            D    G   P+    P   +    E+  VG  G                  SAG+R    
Sbjct: 713  DG-GRGLTGPIGPPGP---AGANGEKGEVGPPGPAG---------------SAGARGAPG 753

Query: 477  EKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAA 536
            E+      G+T P       P   G AGPP A     A G +G+  + +K    A G   
Sbjct: 754  ER------GETGP-------PGPAGFAGPPGADGQPGAKGEQGE--AGQKGDAGAPGPQG 798

Query: 537  PT-ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKT-------VPVPSG 588
            P+ A G   P   G   P     A   P   G   + G+ V  PG          P PSG
Sbjct: 799  PSGAPGPQGP--TGVTGPKGARGAQGPPGATGFPGAAGR-VGPPGSNGNPGPPGPPGPSG 855

Query: 589  KVDPVSLGKAEAIPEGKVG--------SLPLEKGSPVTTTKADPRASGKAQPQSGGKAET 640
            K  P    + ++ P G+ G          P EKG P     +        Q  +G +   
Sbjct: 856  KDGPKG-ARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIV 914

Query: 641  KLPGQEG----AAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGK--A 694
             LPGQ G       PG +G    K+  P AS    P        L    GEP   G   A
Sbjct: 915  GLPGQRGERGFPGLPGPSGEPG-KQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGA 973

Query: 695  DSAPSR------KTESPSLGKV----VPLSLEKTKPSS-SSRQLDRKALGS-----ARSP 738
            D  P R      K +    G V     P       P+  + +Q DR   G+        P
Sbjct: 974  DGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGP 1033

Query: 739  EGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAP 798
             GARG +G   P+ +     EA   G++ L+  G       +    PPGP + D     P
Sbjct: 1034 AGARGIQGPQGPRGD---KGEAGEPGERGLK--GHRGFTGLQGLPGPPGP-SGDQGASGP 1087

Query: 799  SWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAG 858
                + P  PR   G            V P S +DGA G        P    PP  R   
Sbjct: 1088 ----AGPSGPRGPPG-----------PVGP-SGKDGANG-------IPGPIGPPGPRG-- 1122

Query: 859  LQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG---SALAAAVAPPEPAEPVRDVSW 915
                      RS  TGP  P     P  P     PG   SA A      +  +P++ +  
Sbjct: 1123 ----------RSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRA 1172

Query: 916  DEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRS 968
            D+       + A ++      A  K L  QIE      +   P  +R  P R+
Sbjct: 1173 DQAAGGLRQHDAEVD------ATLKSLNNQIE------SIRSPEGSRKNPART 1213



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 152/587 (25%), Positives = 200/587 (34%), Gaps = 86/587 (14%)

Query: 431 KPELLSPG-QAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
           K E  +PG + E  S G+ G+  P     +   R     AG+         P  +G   P
Sbjct: 230 KGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGP 289

Query: 490 VSSG-----PGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLV-ASGKAA----PTA 539
           V        PG P + G AGP  A   E A G +G+P +    G   ASG       P A
Sbjct: 290 VGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGA 349

Query: 540 SGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPG----KTVPVPSGKVDPVSL 595
            G A    +         +   GP G    +        PG    K    P G+  P   
Sbjct: 350 KGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGP 409

Query: 596 GKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQP--QSGGKAETKLPGQEGAA---- 649
             A   P G+ G    ++G+     + +P   G   P  + G       PGQ+G A    
Sbjct: 410 QGAPG-PAGEEG----KRGA-----RGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKG 459

Query: 650 APGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGK 709
           APGE G   L    P+ +   DPG            GEP  L  A     R  ++   GK
Sbjct: 460 APGERGPSGLAG--PKGANG-DPGR----------PGEP-GLPGARGLTGRPGDAGPQGK 505

Query: 710 VVPLSL--EKTKPSSSSRQLDRKALG--SARSPEGARGSEGRVEPKAEPVSSTEASSLGQ 765
           V P     E  +P     Q  R   G      P+GA G  G+   K  P  +     L  
Sbjct: 506 VGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLP-GAPGLRGLPG 564

Query: 766 KDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVA 825
           KD E   A     P   A P G R          ++    PP     G + G Q     A
Sbjct: 565 KDGETGAAG----PPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEA 620

Query: 826 VSP--MSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSV-----ATGPMTP 878
            +P  + P+   G         P     P  +  GLQ   G   T        A+GP  P
Sbjct: 621 GAPGLVGPRGERG--------FPGERGSPGAQ--GLQGPRGLPGTPGTDGPKGASGPAGP 670

Query: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
             A  P  P ++  PG   AA +A P+      DV   EKG      GA  +    G+  
Sbjct: 671 PGAQGP--PGLQGMPGERGAAGIAGPKGDRG--DVG--EKGPE----GAPGKDGGRGLTG 720

Query: 939 QKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPG 985
                     +G +G   PP     GP  S   R AP +     PPG
Sbjct: 721 PIGPPGPAGANGEKGEVGPP-----GPAGSAGARGAPGERGETGPPG 762



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 170/736 (23%), Positives = 231/736 (31%), Gaps = 119/736 (16%)

Query: 291 PGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNG-------PVSSGT------- 336
           PG  G+A P      + A   + EPG  G   PG +G +G       P + G+       
Sbjct: 302 PGAKGEAGPTGARGPEGAQGPRGEPGTPGS--PGPAGASGNPGTDGIPGAKGSAGAPGIA 359

Query: 337 GAPGSLGRLDPT----CLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHT 392
           GAPG  G   P       G   P        +   K +    G+  PA   +G P     
Sbjct: 360 GAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGP-QGAPGPAGE 418

Query: 393 DTTASAKTDLTSLKNVDPMSS-GKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTV 451
           +    A+ +   +  + P    G          D +   K    +PG+      G +G  
Sbjct: 419 EGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKG---APGER-----GPSGLA 470

Query: 452 SPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSS-----GPGDPRSLGTAGPP 506
            P   +    R  +P   G+R  +    +    GK  P  +      PG P   G  G P
Sbjct: 471 GPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQP 530

Query: 507 SAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQ 566
             +      G  G+P  + + GL  +           E  A G   P       AG  G+
Sbjct: 531 GVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPA----GPAGERGE 586

Query: 567 GDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVG-----SLPLEKGSPVTTTK 621
             +         PG   P   G          EA   G VG       P E+GSP     
Sbjct: 587 QGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGL 646

Query: 622 ADPRASGKAQPQSGGKAETKLPGQEGA-------AAPGEAGAVCLKKETPQASEKVDPGS 674
             PR         G K  +   G  GA         PGE GA  +      A  K D G 
Sbjct: 647 QGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGI------AGPKGDRGD 700

Query: 675 CRKAEPL-ASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALG 733
             +  P  A GK     L      P     +   G+V P       P+ S+         
Sbjct: 701 VGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGP-----PGPAGSAGARGAPGER 755

Query: 734 SARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDN 793
               P G  G  G      +P +  E    GQK     G   +P P+  +  PGP+    
Sbjct: 756 GETGPPGPAGFAGPPGADGQPGAKGEQGEAGQK-----GDAGAPGPQGPSGAPGPQGPTG 810

Query: 794 FTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPS 853
            T  P     A  PP        GA      A     P  G+ G+       P  P  PS
Sbjct: 811 VT-GPKGARGAQGPP--------GATGFPGAAGRVGPP--GSNGN-----PGPPGPPGPS 854

Query: 854 RRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG-SALAAAVAPPEPAEPVRD 912
            +D G + + G +     A  P     A PP     +  PG    + A  PP P      
Sbjct: 855 GKD-GPKGARGDSGPPGRAGEPGLQGPAGPPG---EKGEPGDDGPSGAEGPPGP------ 904

Query: 913 VSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAP--PPAARAGPGRSGS 970
                        G A +  ++G+  Q+       E G  G P P   P  +  PG SG 
Sbjct: 905 ------------QGLAGQRGIVGLPGQR------GERGFPGLPGPSGEPGKQGAPGASGD 946

Query: 971 VRTAPPDGAAKRPPGL 986
                P G    PPGL
Sbjct: 947 RGPPGPVG----PPGL 958



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 144/585 (24%), Positives = 192/585 (32%), Gaps = 87/585 (14%)

Query: 437 PGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGD 496
           PG  + + VG  G   PG + P   +       G R    EK  P   G+       PG 
Sbjct: 40  PGDIKDI-VGPKGP--PGPQGPAGEQGP----RGDRGDKGEKGAPGPRGRDGE----PGT 88

Query: 497 PRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLV---ASGKAAPTASGKAEPLAVGKEDP 553
           P + G  GPP      P   G G   +++ AG     A G       G   P+  G   P
Sbjct: 89  PGNPGPPGPPGP----PGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPM--GPRGP 142

Query: 554 VSKGKADAGPSG-QGDSVSIGKVVSTPGKTVPV-PSGKVDPVSL--GKAEAIPEGKVGSL 609
                A  GP G QG+    G+    PG + P+ P G   P        EA   GK G  
Sbjct: 143 PGPAGAP-GPQGFQGNPGEPGE----PGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAG-- 195

Query: 610 PLEKGSPVTT-TKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASE 668
             E+G P     +  P   G      G K     PG +GA   GEAGA  +K E+    E
Sbjct: 196 --ERGPPGPQGARGFPGTPGLP----GVKGHRGYPGLDGAK--GEAGAPGVKGESGSPGE 247

Query: 669 KVDPGSCR-KAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQL 727
              PG    +  P   G+  P     A     +   +   G V P       P +   + 
Sbjct: 248 NGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAG-GPGFPGAPGAKG 306

Query: 728 DRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAA---------------- 771
           +    G AR PEGA+G  G       P  +  + + G   +  A                
Sbjct: 307 EAGPTG-ARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFP 365

Query: 772 GAERSPCPEAAAPPPGPRTRDNFT--------------KAPSWEASAPPPPREDAGTQAG 817
           G    P P+ A  P GP+ +                    P+    AP P  E+    A 
Sbjct: 366 GPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGAR 425

Query: 818 AQACVSVAVSPMSPQDGAGGSAFSFQAAPRAP--SPPSRRDAGLQVSLGAAETRSVATGP 875
            +      + P   +   G   F  Q     P  +P  R  +GL    GA         P
Sbjct: 426 GEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGD------P 479

Query: 876 MTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLG 935
             P     P    +  RPG A       P  A P  D      G      GA  +  V+G
Sbjct: 480 GRPGEPGLPGARGLTGRPGDAGPQGKVGPSGA-PGEDGRPGPPGPQ----GARGQPGVMG 534

Query: 936 MAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAA 980
               K    +  + G +G P  P   R  PG+ G    A P G A
Sbjct: 535 FPGPKGANGEPGKAGEKGLPGAP-GLRGLPGKDGETGAAGPPGPA 578


>gi|153070260 myristoylated alanine-rich protein kinase C substrate
           [Homo sapiens]
          Length = 332

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 92/337 (27%), Positives = 126/337 (37%), Gaps = 24/337 (7%)

Query: 555 SKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKG 614
           +KG+A A   G+        V S+P K     +G V         A   G    L    G
Sbjct: 10  AKGEAAAERPGEA------AVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQAN-G 62

Query: 615 SPVTTTKADPRA--SGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDP 672
           S     K +P A  SG A P +  K      G+  AAA  EAGA  ++KE P   E  +P
Sbjct: 63  SAPAADKEEPAAAGSGAASPSAAEK------GEPAAAAAPEAGASPVEKEAPAEGEAAEP 116

Query: 673 GSCRKAEPLASGKGEPVSLGKAD--SAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRK 730
           GS   AE  A+      S  KA+  + PS   E+P   K      +  K S  S + ++K
Sbjct: 117 GSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKK 176

Query: 731 ALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRT 790
             G     E      G+ E  A   ++  A+  G    E A A   P  EAAA   G   
Sbjct: 177 EAGEGGEAEAPAAEGGKDE--AAGGAAAAAAEAGAASGEQAAA---PGEEAAAGEEGAAG 231

Query: 791 RDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPS 850
            D     P   A AP  P     T+A  +   S      + + GA  +A    +A    +
Sbjct: 232 GDPQEAKPQEAAVAPEKPPASDETKAAEEP--SKVEEKKAEEAGASAAACEAPSAAGPGA 289

Query: 851 PPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFP 887
           PP +  A  +    AA + + A      Q    P  P
Sbjct: 290 PPEQEAAPAEEPAAAAASSACAAPSQEAQPECSPEAP 326



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 88/373 (23%), Positives = 133/373 (35%), Gaps = 59/373 (15%)

Query: 446 GKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGP 505
           G+A    PG+    SS    P  A  ++    KVN    G  +P ++  G    L   G 
Sbjct: 12  GEAAAERPGEAAVASS----PSKANGQENGHVKVN----GDASPAAAESGAKEELQANGS 63

Query: 506 -PSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPS 564
            P+A K EPA  G              SG A+P+A+ K EP A    +  +       P+
Sbjct: 64  APAADKEEPAAAG--------------SGAASPSAAEKGEPAAAAAPEAGASPVEKEAPA 109

Query: 565 GQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADP 624
            +G++   G   +  G+     S    P +   A   P  +      ++ S   + K   
Sbjct: 110 -EGEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSG 168

Query: 625 RASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASG 684
            +  K + ++G   E + P  EG       GA     E   AS +            A+ 
Sbjct: 169 FSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGE-----------QAAA 217

Query: 685 KGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGS 744
            GE  + G+  +A       P   K    ++   KP +S          +  + E ++  
Sbjct: 218 PGEEAAAGEEGAAGG----DPQEAKPQEAAVAPEKPPASDE--------TKAAEEPSKVE 265

Query: 745 EGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAA-APPPGPRTRDNFTKAPSWEA- 802
           E + E      ++ EA S       AAG    P  EAA A  P      +   APS EA 
Sbjct: 266 EKKAEEAGASAAACEAPS-------AAGPGAPPEQEAAPAEEPAAAAASSACAAPSQEAQ 318

Query: 803 ---SAPPPPREDA 812
              S   PP E A
Sbjct: 319 PECSPEAPPAEAA 331



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 93/375 (24%), Positives = 133/375 (35%), Gaps = 60/375 (16%)

Query: 638  AETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCR---KAEPLASGKGEPVSLGKA 694
            ++T   G+  A  PGEA        +P  +   + G  +    A P A+  G    L   
Sbjct: 6    SKTAAKGEAAAERPGEAAVA----SSPSKANGQENGHVKVNGDASPAAAESGAKEELQAN 61

Query: 695  DSAPSRKTESPSL---GKVVPLSLEKTKPSSSSRQLDRKALGSARSP-EGARGSEGRVEP 750
             SAP+   E P+    G   P + EK +P++++      A  +  SP E    +EG    
Sbjct: 62   GSAPAADKEEPAAAGSGAASPSAAEKGEPAAAA------APEAGASPVEKEAPAEGEA-- 113

Query: 751  KAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPRE 810
             AEP S T A        EAA A        A+    P+  D  T +PS E    P  ++
Sbjct: 114  -AEPGSPTAAEG------EAASA--------ASSTSSPKAEDGATPSPSNET---PKKKK 155

Query: 811  DAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRS 870
               +   +      +      + G GG A     AP A       + G   + G A   +
Sbjct: 156  KRFSFKKSFKLSGFSFKKNKKEAGEGGEA----EAPAA-------EGGKDEAAGGAAAAA 204

Query: 871  VATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAME 930
               G  + + AA P         G    AA   P+ A+P       EK    +   AA E
Sbjct: 205  AEAGAASGEQAAAPGEEAAAGEEG----AAGGDPQEAKPQEAAVAPEKPPASDETKAAEE 260

Query: 931  VEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRAL 990
                     K  E++ EE G   A    P+A AGPG       AP +  A        A 
Sbjct: 261  PS-------KVEEKKAEEAGASAAACEAPSA-AGPGAPPEQEAAPAEEPAAAAASSACAA 312

Query: 991  LQSVRRPRCCSRAGP 1005
                 +P C   A P
Sbjct: 313  PSQEAQPECSPEAPP 327



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 61/298 (20%), Positives = 105/298 (35%), Gaps = 87/298 (29%)

Query: 50  QKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKET 109
           ++   A    +P ++ G E+ H   +G    A+                    ES +KE 
Sbjct: 17  ERPGEAAVASSPSKANGQENGHVKVNGDASPAAA-------------------ESGAKEE 57

Query: 110 LEAHG---ASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSI 166
           L+A+G   A+    P A  SG   P ++ K EP ++              ++ +A ++ +
Sbjct: 58  LQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAA--------------AAPEAGASPV 103

Query: 167 GKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTY 226
            KE P     A+P     AE E                                 S+ + 
Sbjct: 104 EKEAPAEGEAAEPGSPTAAEGE-------------------------------AASAASS 132

Query: 227 TVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLS 286
           T SP+ ED  +     P  S++     P+K++ R+S K+    S K++  S +K      
Sbjct: 133 TSSPKAEDGAT-----PSPSNET----PKKKKKRFSFKK----SFKLSGFSFKK------ 173

Query: 287 GKRDPGPSGKAD-PMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLG 343
            K++ G  G+A+ P      D A+ G            G         +  G  G+ G
Sbjct: 174 NKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAG 231


>gi|82534351 microtubule-associated protein tau isoform 1 [Homo
           sapiens]
          Length = 758

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 132/560 (23%), Positives = 208/560 (37%), Gaps = 95/560 (16%)

Query: 387 PVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKP--ELLSPGQAERVS 444
           P    ++   S  +D  S    + +++  VD  + GK     + +P  E+     AE   
Sbjct: 51  PTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQ---AAAQPHTEIPEGTTAEEAG 107

Query: 445 VGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSG-PGDPRSLGTA 503
           +G     +P  ED  +        +G          P   G ++ + SG PG P  L   
Sbjct: 108 IGD----TPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAP--LLPE 161

Query: 504 GP------PSAVKAEPATGGKGDP--LSSEKAG-LVASGKAAPTASGKAEPLA------- 547
           GP      PS    E   GG+  P  L  +  G L   G     A GK  P +       
Sbjct: 162 GPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDED 221

Query: 548 --VGKEDPVSKGKADAGPS--GQGDSVSIGKVVSTPG----KTVPVPSGKVDPVSLGKAE 599
             V +  P     + A P+  G+    +  +  S PG      +P+P   +  VS     
Sbjct: 222 RDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPA 281

Query: 600 AIPEG------KVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGE 653
           + P+G      K    PLE    V  T    +    ++   G  A    PG+   A    
Sbjct: 282 SEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPS 341

Query: 654 AGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPL 713
            G    + + P+ SEK         +P A+ +G+PVS  +     +R       G     
Sbjct: 342 LGEDTKEADLPEPSEK---------QPAAAPRGKPVS--RVPQLKARMVSKSKDGTGSDD 390

Query: 714 SLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKA-----EPVSS--------TEA 760
              KT   SS++ L  +   S + P     S+  ++P +     EP SS        +  
Sbjct: 391 KKAKTSTRSSAKTLKNRPCLSPKHPTPG-SSDPLIQPSSPAVCPEPPSSPKHVSSVTSRT 449

Query: 761 SSLGQKDLEAAGAE---RSPCPEAAAPPPGPRTRDNFTKAPSWEASAPP-PPREDAGTQA 816
            S G K+++  GA+   +   P  AAPP G + + N T+ P+    AP  PP      ++
Sbjct: 450 GSSGAKEMKLKGADGKTKIATPRGAAPP-GQKGQANATRIPAKTPPAPKTPPSSGEPPKS 508

Query: 817 GAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPM 876
           G ++  S   SP SP     G+  S    P  P+PP+R    + V         V T P 
Sbjct: 509 GDRSGYS---SPGSP-----GTPGSRSRTPSLPTPPTREPKKVAV---------VRTPPK 551

Query: 877 TPQAA------APPAFPEVR 890
           +P +A      AP   P+++
Sbjct: 552 SPSSAKSRLQTAPVPMPDLK 571



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 128/568 (22%), Positives = 188/568 (33%), Gaps = 89/568 (15%)

Query: 225 TYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHP---VSSEKVAPTSAEKV 281
           TY +  RK+  G     D              + P   G E P    S  K  PT AE V
Sbjct: 17  TYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPT-AEDV 75

Query: 282 DLVLSGKRDPGPSGKADPMP---------------LESMDSASTGK-TEPGLLGKLI--- 322
              L  +  PG    A P                   S++  + G  T+    GK++   
Sbjct: 76  TAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEG 135

Query: 323 ----PGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMD 378
               PG  G +  + SG   PG+    +        P+  G  +T            ++ 
Sbjct: 136 FLREPGPPGLSHQLMSGM--PGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLL 193

Query: 379 PASSGEGRPVSGHTDTTA-SAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSP 437
                EG P+ G        +K ++   ++VD  S     P    K  P   G+P   + 
Sbjct: 194 GDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPP---SKASPAQDGRPPQTAA 250

Query: 438 GQAERVS--------------VGKAGTVSPGKE-DPVSSRREDPISAGSRKTSSEKVNPE 482
            +A  +               + K  T  P  E D  S  R     A    T   ++ P 
Sbjct: 251 REATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITP- 309

Query: 483 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK 542
                N           LG A  P A    P   G      +++A L    +  P A+ +
Sbjct: 310 -----NVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPR 364

Query: 543 AEPLAVG---KEDPVSKGKADAGPSGQGDSVSIGKVVST----PGKTVPVPS-GKVDPVS 594
            +P++     K   VSK K   G   +    S      T    P  +   P+ G  DP+ 
Sbjct: 365 GKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLI 424

Query: 595 LGKAEAI-PEGKVGSLPLEKGSPVTTTKADPRASG-KAQPQSGGKAETKLPGQEGAAAPG 652
              + A+ PE      P      V++  +   +SG K     G   +TK+    GAA PG
Sbjct: 425 QPSSPAVCPE------PPSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPG 478

Query: 653 EAG---AVCLKKETPQASEKVDPGSCRKAEPLASG----------KGEPVSLGKADSAPS 699
           + G   A  +  +TP A  K  P S    EP  SG           G P S  +  S P+
Sbjct: 479 QKGQANATRIPAKTPPA-PKTPPSS---GEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPT 534

Query: 700 RKTESPSLGKVVPLSLEKTKPSSSSRQL 727
             T  P   KV  +      PSS+  +L
Sbjct: 535 PPTREPK--KVAVVRTPPKSPSSAKSRL 560



 Score = 35.0 bits (79), Expect = 0.36
 Identities = 85/404 (21%), Positives = 141/404 (34%), Gaps = 55/404 (13%)

Query: 30  PQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRG 89
           P  G+ G      ++     +    + P+ +P          R P  A   A+   G   
Sbjct: 202 PLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPA 261

Query: 90  SLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVS---------SVKTEPK 140
             A P P  F  + S      E  G S+         G+  P+          +V+ E  
Sbjct: 262 EGAIPLPVDFLSKVSTEIPASEPDGPSV-----GRAKGQDAPLEFTFHVEITPNVQKEQA 316

Query: 141 SSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGR 200
            S++     L +  F  +      + G      +++AD     + +P    +G PV+  R
Sbjct: 317 HSEEH----LGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVS--R 370

Query: 201 MDPMTVR-----KEDLGS---LGKVDPLCSSKTY----TVSPRKEDPGSLRKVDPVSSDK 248
           +  +  R     K+  GS     K     S+KT      +SP+   PGS   +   SS  
Sbjct: 371 VPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPA 430

Query: 249 VDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDL----------VLSGKRDPGPSGKAD 298
           V P      EP  S K     + +   + A+++ L             G   PG  G+A+
Sbjct: 431 VCP------EPPSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQAN 484

Query: 299 PMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGT-GAPGSLGRLD--PTCLGMADP 355
              + +  +    KT P       P S  ++G  S G+ G PGS  R    PT     +P
Sbjct: 485 ATRIPA-KTPPAPKTPPS--SGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPT-PPTREP 540

Query: 356 ASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAK 399
             V  V T P +   ++   +  P    + + V     +T + K
Sbjct: 541 KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLK 584


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 225/934 (24%), Positives = 299/934 (32%), Gaps = 147/934 (15%)

Query: 45   YCPSQQKASPAPP----RHTPDQSPGMESRHRSPSGAGE-GASCSDGPRGSLACPSPTCF 99
            YCP  QK  P       +  P   PG+  R  +P   G  G++ + G RG      P   
Sbjct: 1250 YCPKGQKGEPGEMGLRGQVGPPGDPGLPGRTGAPGPQGPPGSATAKGERGF-----PGAD 1304

Query: 100  SPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSK 159
                SP +       A   GTP A        +   + +P     R P        K   
Sbjct: 1305 GRPGSPGR-------AGNPGTPGAPGLKGSPGLPGPRGDPGERGPRGP--------KGEP 1349

Query: 160  QADSTSIGKEDPG-SSRKADPMFTGKAEPE-ILGKGDPVAPGRMDPMTVRKEDLGSLGKV 217
             A    IG E PG   RK DP  +G   P   LG   P  P  + P T  K D G  G+ 
Sbjct: 1350 GAPGQVIGGEGPGLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGL-PGTAMKGDKGDRGER 1408

Query: 218  DPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKE--------HPVS 269
             P    +          PG      P S     PV P  ++      E         P S
Sbjct: 1409 GPPGPGEGGIAPGEPGLPGL-----PGSPGPQGPVGPPGKKGEKGDSEDGAPGLPGQPGS 1463

Query: 270  SEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKN 329
              +  P            +  PGP G+A           +  +  PG+ G+  PG+ G  
Sbjct: 1464 PGEQGPRGPPGAIGPKGDRGFPGPLGEAGEKGERGPPGPAGSRGLPGVAGR--PGAKGPE 1521

Query: 330  GPVSSGTGAPGSLGRL----DPTCLGMA-----------DPASVGNVETVPATKEDSRFL 374
            GP    TG  G  G      DP  +G A            PA       V   +     +
Sbjct: 1522 GPPGP-TGRQGEKGEPGRPGDPAVVGPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLV 1580

Query: 375  GKMDPASSGE--GRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKP 432
               DP   G+   R   G T             +  DP   G   PV     D     K 
Sbjct: 1581 LPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKG 1640

Query: 433  ELLSPGQAERVSVGKAGTV----SPGKEDPVSSRRE--DPISAGSRKTSSEKVNPESSGK 486
            +   PG       GKAG      +PG   PV  + +  DP   G   +          G+
Sbjct: 1641 DEGPPGDPGLP--GKAGERGLRGAPGVRGPVGEKGDQGDPGEDGRNGSPGSSGPKGDRGE 1698

Query: 487  TNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSE-KAGLVASGKAAPTASGKAEP 545
              P    PG P  L   GP +  K EP   G+  P   +   GL  +         +  P
Sbjct: 1699 PGP----PGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDPGLPGAPGERGIEGFRGPP 1754

Query: 546  LAVGKEDPVSKG----KADAGPSG-QGDSVSIGKVVSTPGKTVPV-PSGKVDPVSLGKAE 599
               G  DP  +G    K D GP G  G S   GK    PG   P  P+G          +
Sbjct: 1755 GPQG--DPGVRGPAGEKGDRGPPGLDGRSGLDGK----PGAAGPSGPNGAAGKAGDPGRD 1808

Query: 600  AIP--EGKVGSLPLEKGSPVTTTK----ADPRASGK-AQP-------QSGGKAETKLPGQ 645
             +P   G+ G LP   G P    K      P  +GK  +P       + G K ++   G+
Sbjct: 1809 GLPGLRGEQG-LPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEKGDSGASGR 1867

Query: 646  EGAAAP-GEAGA--VCLKKETPQASEKV-DPGSCRKAEPLASG----KGEPVSLGKADSA 697
            EG   P GE GA  +   +  P     V  PG      P  +G    +GE  S G+    
Sbjct: 1868 EGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGFPGVPGGTGPKGDRGETGSKGEQGLP 1927

Query: 698  PSR--KTESPSLGKVVPLSLEKTKPSSSSRQL----DRKALGSARSPEGARGSEGRVEPK 751
              R  + E  S+  V  L       +S+ R++    D  +      PE  RG +G    +
Sbjct: 1928 GERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSFLPVPERRRGPKGDSGEQ 1987

Query: 752  AEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPRED 811
              P         G++ L+  G    P P+    PPG    +     PS  A  P  P   
Sbjct: 1988 GPPGKEGPIGFPGERGLK--GDRGDPGPQG---PPGLALGERGPPGPSGLAGEPGKP--- 2039

Query: 812  AGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSV 871
                                  G  G          A  P  R + G +   G       
Sbjct: 2040 ----------------------GIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGP 2077

Query: 872  ATGPMTPQAAAPPAFPEVRV-RPGSALAAAVAPP 904
               P TP    PP  P+V V  PG  L+    PP
Sbjct: 2078 PGLPGTPGPPGPPG-PKVSVDEPGPGLSGEQGPP 2110



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 162/634 (25%), Positives = 219/634 (34%), Gaps = 106/634 (16%)

Query: 314  EPGLLGKLIPGSSGKNGPVSSGT-----GAPGSLGRLDPTCLGMADPASVGNVET--VPA 366
            +PGL G+   G+ G  GP  S T     G PG+ GR          P   GN  T   P 
Sbjct: 1273 DPGLPGRT--GAPGPQGPPGSATAKGERGFPGADGR-------PGSPGRAGNPGTPGAPG 1323

Query: 367  TKEDSRFLG-KMDPASSGEGRPVS--GHTDTTASAKTDLTSLKNVDPMSSGKVDPVS-LG 422
             K      G + DP   G   P    G        +      +  DP  SG   P   LG
Sbjct: 1324 LKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGPRGPLG 1383

Query: 423  KMDPMCSGKPELLSPGQAERVSVGKAGT----------VSPGKED----PVSSRREDPIS 468
              DP   G P L  PG A +   G  G           ++PG+      P S   + P+ 
Sbjct: 1384 --DPGPRGPPGL--PGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQGPVG 1439

Query: 469  AGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAG 528
               +K   EK + E      P    PG P   G  GPP A+  +   G +G P    +AG
Sbjct: 1440 PPGKK--GEKGDSEDGAPGLP--GQPGSPGEQGPRGPPGAIGPK---GDRGFPGPLGEAG 1492

Query: 529  LVASGKAAPTASGKAEPLAVGKEDPVSKG-KADAGPSG-QGDSVSIGKVVSTPGKTVPVP 586
                      A  +  P   G+  P +KG +   GP+G QG+    G+    PG      
Sbjct: 1493 EKGERGPPGPAGSRGLPGVAGR--PGAKGPEGPPGPTGRQGEKGEPGR----PG------ 1540

Query: 587  SGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQE 646
                DP  +G A A P+G+ G +            A PR +   Q + G      LPG  
Sbjct: 1541 ----DPAVVGPAVAGPKGEKGDV----------GPAGPRGATGVQGERGPPG-LVLPGDP 1585

Query: 647  GAAA-PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESP 705
            G    PG+ G + L        +   PG   K +P   G   PV     D     K +  
Sbjct: 1586 GPKGDPGDRGPIGLTGRAGPPGDSGPPG--EKGDPGRPGPPGPVGPRGRDGEVGEKGDEG 1643

Query: 706  SLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ 765
              G       +   P  +  +  R A G  R P G +G +G  +P  +  + +  SS  +
Sbjct: 1644 PPG-------DPGLPGKAGERGLRGAPG-VRGPVGEKGDQG--DPGEDGRNGSPGSSGPK 1693

Query: 766  KDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQ-AGAQACVSV 824
             D    G    P P       GP  R+        +   P  P+ D G   A  +  +  
Sbjct: 1694 GD---RGEPGPPGPPGRLVDTGPGAREKGEPGDRGQ-EGPRGPKGDPGLPGAPGERGIEG 1749

Query: 825  AVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPP 884
               P  PQ   G    + +   R P P     +GL    GAA       GP  P  AA  
Sbjct: 1750 FRGPPGPQGDPGVRGPAGEKGDRGP-PGLDGRSGLDGKPGAA-------GPSGPNGAAGK 1801

Query: 885  AFPEVR-----VRPGSALAAAVAPPE-PAEPVRD 912
            A    R     +R    L     PP  P +P  D
Sbjct: 1802 AGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGED 1835



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 212/859 (24%), Positives = 282/859 (32%), Gaps = 146/859 (16%)

Query: 51   KASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQES-PSKET 109
            +  P P      + P  E   R P G  +G S  DG  G+     P   + +   P ++ 
Sbjct: 1751 RGPPGPQGDPGVRGPAGEKGDRGPPGL-DGRSGLDGKPGAAGPSGPNGAAGKAGDPGRDG 1809

Query: 110  L-----EAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADST 164
            L     E      SG P     GKP          K+ +  +P      D +  ++ DS 
Sbjct: 1810 LPGLRGEQGLPGPSGPPGLP--GKPGEDGKPGLNGKNGEPGDP----GEDGRKGEKGDSG 1863

Query: 165  SIGKE--DPGSSRKADPMFTGKAEPEIL-------GKGDPVAPGRMDPMTVRKE------ 209
            + G+E  D     +  P   G   P  L       G+G P  PG   P   R E      
Sbjct: 1864 ASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGFPGVPGGTGPKGDRGETGSKGE 1923

Query: 210  -----------DLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
                       + GS+  VD L  +     S  +E    + +    SS    PV  R+  
Sbjct: 1924 QGLPGERGLRGEPGSVPNVDRLLETAGIKASALRE----IVETWDESSGSFLPVPERRRG 1979

Query: 259  PRY-SGKEHPVSSEKVAPTSAEKVDLVLSGKR-DPGPSGKADPMPLESMDSASTGKT-EP 315
            P+  SG++ P   E       E+    L G R DPGP G       E      +G   EP
Sbjct: 1980 PKGDSGEQGPPGKEGPIGFPGERG---LKGDRGDPGPQGPPGLALGERGPPGPSGLAGEP 2036

Query: 316  GLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTC----LGMADPASVGNVETVPATKEDS 371
            G  G  IPG  G+ G V    G PG  G           G   P  +      P      
Sbjct: 2037 GKPG--IPGLPGRAGGVGEA-GRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPPGPK 2093

Query: 372  RFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGK 431
              + +  P  SGE  P          AK +  S  +  P     V  +   + +P   G+
Sbjct: 2094 VSVDEPGPGLSGEQGPPG-----LKGAKGEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQ 2148

Query: 432  PELLSPG-QAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPV 490
                +PG   ER   G  G   PG + P    R  P   G              G   P 
Sbjct: 2149 DG--NPGLPGERGMAGPEG--KPGLQGP----RGPPGPVGGH------------GDPGP- 2187

Query: 491  SSGPGDPRSLGTAGP--PSAVKAEPA-TGGKGDPLSSEKAGLVASGKAAPTA-----SGK 542
               PG P   G AGP  PS +K EP  TG  G  L+     +   G   P+         
Sbjct: 2188 ---PGAPGLAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSP 2244

Query: 543  AEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPV-PSGKVDPVSL-GKAEA 600
              P  VG+         D      GD  S G V  +PG   PV P G+  P    G+A  
Sbjct: 2245 GLPGQVGETGKPGAPGRDGASGKDGDRGSPG-VPGSPGLPGPVGPKGEPGPTGAPGQAVV 2303

Query: 601  IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
               G  G    EKG+P          +G    + G K +  LPG  G    GEAG     
Sbjct: 2304 GLPGAKG----EKGAP-------GGLAGDLVGEPGAKGDRGLPGPRGEK--GEAG----- 2345

Query: 661  KETPQASEKVDPGSC-RKAEPLASG-KGEP-VSLGKADSAPSRKTESPSLGK-------- 709
                +A E  DPG   +K  P   G KG+P V +  +   P        LG         
Sbjct: 2346 ----RAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPGPPGVKGDLGLPGLPGAPG 2401

Query: 710  VVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLE 769
            VV     +T P     Q           P G  G  G + P   P S     + G K  +
Sbjct: 2402 VVGFP-GQTGPRGEMGQPGPSGERGLAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGDK 2460

Query: 770  AAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEA----SAPPPPREDAGTQA--------G 817
                   P P      PG R  D     P  E     + PP  R + G +         G
Sbjct: 2461 GDPGVGLPGPRGERGEPGIRGEDG---RPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKG 2517

Query: 818  AQACVSVAVSPMSPQDGAG 836
             +   +V + P  P+   G
Sbjct: 2518 DKGDSAVILGPPGPRGAKG 2536



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 231/962 (24%), Positives = 309/962 (32%), Gaps = 180/962 (18%)

Query: 13   LQKDSSPPGPR-PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH 71
            L+ D   PGP+ P      + G  G    A     P +      P R       G     
Sbjct: 2004 LKGDRGDPGPQGPPGLALGERGPPGPSGLAGE---PGKPGIPGLPGRAGGVGEAGRPGER 2060

Query: 72   RSPSGAGE-GASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPE 130
                  GE G    DGP G    P P    P     K +++  G  +SG         P 
Sbjct: 2061 GERGEKGERGEQGRDGPPGLPGTPGP----PGPPGPKVSVDEPGPGLSGEQG------PP 2110

Query: 131  PVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPG----SSRKADPMFTGKAE 186
             +   K EP S+ D+ P        K  +        + +PG          P   G A 
Sbjct: 2111 GLKGAKGEPGSNGDQGP--------KGDRGVPGIKGDRGEPGPRGQDGNPGLPGERGMAG 2162

Query: 187  PEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSS 246
            PE    G P   G   P       +G  G   P               PG+     P   
Sbjct: 2163 PE----GKPGLQGPRGP----PGPVGGHGDPGP---------------PGAPGLAGPAGP 2199

Query: 247  DKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMD 306
                 +   K EP   G+  P       PT A    + L G   PGPSG   P     + 
Sbjct: 2200 QGPSGL---KGEP---GETGPPGRGLTGPTGA----VGLPGP--PGPSGLVGPQGSPGLP 2247

Query: 307  SASTGKTEPGLLGKLIPGSSGKNGP-----VSSGTGAPGSLG-RLDPTCLGMADPASVGN 360
                   +PG  G+   G+SGK+G      V    G PG +G + +P   G    A VG 
Sbjct: 2248 GQVGETGKPGAPGR--DGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAVVG- 2304

Query: 361  VETVPATKEDSRFLGKM------DPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSG 414
               +P  K +    G +      +P + G+ R + G       A     + +  DP   G
Sbjct: 2305 ---LPGAKGEKGAPGGLAGDLVGEPGAKGD-RGLPGPRGEKGEAGR---AGEPGDPGEDG 2357

Query: 415  -KVDPVSLGKMDPMCSGKPELLSPGQAERVSV-GKAGTVS-PGKEDPVSSRREDPISAGS 471
             K  P   G       G P   SPG      V G  G    PG    V      P   G 
Sbjct: 2358 QKGAPGPKGFKGDPGVGVPG--SPGPPGPPGVKGDLGLPGLPGAPGVVGF----PGQTGP 2411

Query: 472  RKTSSEKVNPESSGKTNPVSSGP----GDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKA 527
            R    E   P  SG+     +GP    G P  LG  GPP +V    A+G KGD       
Sbjct: 2412 R---GEMGQPGPSGERG--LAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGD------- 2459

Query: 528  GLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPS 587
                                  K DP   G    GP G+     I      PG+    P 
Sbjct: 2460 ----------------------KGDP---GVGLPGPRGERGEPGIRGEDGRPGQ--EGPR 2492

Query: 588  GKVDPVSLGKAEAIPEGKVGSLPL--EKG-SPVTTTKADPRAS----GKAQPQ-----SG 635
            G   P    + E   +G VGS  L  +KG S V      PR +    G+  P+      G
Sbjct: 2493 GLTGPPG-SRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGAKGDMGERGPRGLDGDKG 2551

Query: 636  GKAETKLPGQEGA-AAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKA 694
             + +   PG +G+   PG+ G+  L         +  PG+       A   G+P S GK 
Sbjct: 2552 PRGDNGDPGDKGSKGEPGDKGSAGLPGLRGLLGPQGQPGA-------AGIPGDPGSPGK- 2603

Query: 695  DSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD-RKALGSARSPEGARGSEGRVEPKAE 753
            D  P  + E   +G + P  L+  +    +  LD  K       P G  G  G      E
Sbjct: 2604 DGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAGPPGRPGLAGHKGEMGE 2663

Query: 754  PVSSTEASSLGQKDLEAAGAER----SPCP--------EAAAPP----PGPRTRDNFTKA 797
            P    ++ + G++ L     +R     P P        E   P     PGP   D     
Sbjct: 2664 PGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQGEKGERGTPGIGGFPGPSGNDGSAGP 2723

Query: 798  PSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDA 857
            P    S  P   E    Q G +      V       GA G     +     P P   R  
Sbjct: 2724 PGPPGSVGPRGPEGLQGQKGERGPPGERVVGAPGVPGAPGE----RGEQGRPGPAGPRGE 2779

Query: 858  GLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPE-PAEPVRDVSWD 916
              + +L   + R      M+   A    F     RP  + AA  A  +  A PV  VS  
Sbjct: 2780 KGEAALTEDDIRGFVRQEMSQHCACQGQFIASGSRPLPSYAADTAGSQLHAVPVLRVSHA 2839

Query: 917  EK 918
            E+
Sbjct: 2840 EE 2841



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 125/520 (24%), Positives = 169/520 (32%), Gaps = 88/520 (16%)

Query: 519  GDPLSSEKAGLV-ASGKAAPTASGKAEPLAVGKEDPVSKG-KADAGPSGQGDSVSIGKVV 576
            G  L    +GL  A  +A+ T   + EP  V       KG K + G  G    V      
Sbjct: 1219 GPSLDQAVSGLATALCQASFTTQPRPEPCPVY----CPKGQKGEPGEMGLRGQVGPPGDP 1274

Query: 577  STPGKT-VPVPSGKVDPVSLGKAEAIP--EGKVGS-----------LPLEKGSP-VTTTK 621
              PG+T  P P G     +       P  +G+ GS            P  KGSP +   +
Sbjct: 1275 GLPGRTGAPGPQGPPGSATAKGERGFPGADGRPGSPGRAGNPGTPGAPGLKGSPGLPGPR 1334

Query: 622  ADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAG----------AVCLKKETPQASEKVD 671
             DP   G   P+    A  ++ G EG   PG  G             L    P+    + 
Sbjct: 1335 GDPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGL- 1393

Query: 672  PGSCRKAEPLASGKGEPVSLGKADSAPSRK-----TESPS-LGKVVPLSLEKTKPSSSSR 725
            PG+  K +    G+  P   G+   AP          SP   G V P   +  K  S   
Sbjct: 1394 PGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQGPVGPPGKKGEKGDSEDG 1453

Query: 726  QLDRKALGSARSPEGARGSEGRVEPKAE---PVSSTEASSLGQKDLEAAGAERS------ 776
                     +   +G RG  G + PK +   P    EA   G++        R       
Sbjct: 1454 APGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEAGEKGERGPPGPAGSRGLPGVAG 1513

Query: 777  -PCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGA 835
             P  +    PPGP  R    +    E   P  P       AG +      V P  P+   
Sbjct: 1514 RPGAKGPEGPPGPTGR----QGEKGEPGRPGDPAVVGPAVAGPKG-EKGDVGPAGPRGAT 1568

Query: 836  GGSAFSFQAAPRAPSPPS-RRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPG 894
            G            P  P  + D G +  +G     +   GP  P  + PP       RPG
Sbjct: 1569 GVQGERGPPGLVLPGDPGPKGDPGDRGPIGL----TGRAGP--PGDSGPPGEKGDPGRPG 1622

Query: 895  SALAAAVAPPEPAEP-VRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHL------ERQIE 947
                    PP P  P  RD    EKG      G   +  + G A ++ L         + 
Sbjct: 1623 --------PPGPVGPRGRDGEVGEKGDE----GPPGDPGLPGKAGERGLRGAPGVRGPVG 1670

Query: 948  EHGRQGAPAPPPAARAGPGRSGSVRTAPPDG--AAKRPPG 985
            E G QG P          GR+GS  ++ P G      PPG
Sbjct: 1671 EKGDQGDPGE-------DGRNGSPGSSGPKGDRGEPGPPG 1703


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 123/513 (23%), Positives = 178/513 (34%), Gaps = 68/513 (13%)

Query: 431 KPELLSPGQAERVSVGKA-GTVSPGKEDPVSSRREDPIS-----------AGSRKTSSEK 478
           K +    G A R    +A G ++P    P S R   P++           A  RK  +E+
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTP--RPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61

Query: 479 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAE---PATGGKGDPLSSEKAGLVASGKA 535
                 G T P S+    P    T+ PP++ + E   PA      P+SS      ASG  
Sbjct: 62  AGG-IGGATIPESAPRAGPTR--TSRPPASGRGERAPPAKNTSPGPVSSPGR---ASGTT 115

Query: 536 APTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSL 595
            P   G+ + L +  E+ V++GKA   P     S    +  S P    P P+      + 
Sbjct: 116 RPGPLGQ-KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 174

Query: 596 GKAEAIPEGKVGSLP----------LEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQ 645
           G    +P     + P          +   S  +TT+  P A  + +P +GG  +      
Sbjct: 175 GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA--RRRPSAGGGLQRPASRS 232

Query: 646 EGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLG-----KADSAPSR 700
             ++A            TP +S      S R      +   +P   G          P R
Sbjct: 233 LSSSA------------TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR 280

Query: 701 KTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEA 760
           K  +P+LG +    L    PS+        +L +  SP     S+      +  + +T  
Sbjct: 281 KDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH- 339

Query: 761 SSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQA 820
           S L    L          P A A PP           PS  AS P  P      QA    
Sbjct: 340 SFLPSPPLSPLATPPPQAPPALALPP-------LQAPPSPPASPPLSPLATPSPQAPNAL 392

Query: 821 CVSVAVSPMSPQDGAGGSA-FSFQAAPR---APSPPSRRDAGLQVSLGAAETRSVATGPM 876
            V +  +P SP       A FS  A+P    + +PPS+    L            A+ PM
Sbjct: 393 AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452

Query: 877 TPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEP 909
           +P A  PP  P     P   LA    PP  A P
Sbjct: 453 SPSATPPPQAPPPLAAPPLQLA---KPPPQAPP 482



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 163/695 (23%), Positives = 231/695 (33%), Gaps = 131/695 (18%)

Query: 285 LSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGT----GAPG 340
           +  KRD   +G A   P             PGLL    PGS     PV+       GA G
Sbjct: 1   MDNKRDKAKAGAAARTP---------AARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAG 51

Query: 341 SLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKT 400
           ++GR       +A+ A      T+P +   +       P +SG G       +    AK 
Sbjct: 52  AVGRKP-----LAERAGGIGGATIPESAPRAGPTRTSRPPASGRG-------ERAPPAKN 99

Query: 401 DLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAER------VSVGKAGTVS-- 452
                 +    +SG   P  LG+     S + E ++ G+A        +S G     S  
Sbjct: 100 TSPGPVSSPGRASGTTRPGPLGQKGLRISAE-ETVARGKATEAPKRSALSAGARRDTSGP 158

Query: 453 -PGKEDPVSSRREDPISAGS-----RKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPP 506
            PG   P  +RR    +AG+     R   S +  P + G    VSS         T  P 
Sbjct: 159 TPGTPSPAMARRSR--AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH----STTEPS 212

Query: 507 SAVKAEPATGG-----KGDPLSSEKAGLVASGKAAPTASG-----------KAEPLAVGK 550
            A +  P+ GG         LSS    L +  ++ P+A G           K + L   +
Sbjct: 213 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 272

Query: 551 EDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLP 610
              V+  + DA P+       +G + S+P  T P PS    P +    + +P     S P
Sbjct: 273 PPQVTPPRKDAAPA-------LGPLSSSPLAT-PSPSAPPSPSAPPSLQTLP-----SPP 319

Query: 611 LEKGSPVTTTKADPRA------------SGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC 658
               S  TT+   P              S  A P         LP  +   +P  +  + 
Sbjct: 320 ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 379

Query: 659 -LKKETPQASEKVD------PGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVV 711
            L   +PQA   +       P S   + P+ +    P S   + SA       PSL    
Sbjct: 380 PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP 439

Query: 712 -----------PLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEA 760
                      P+S   T P  +   L    L  A+ P  A        P  + + S  A
Sbjct: 440 LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA--PPALATPPLQALPSPPA 497

Query: 761 SSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQA 820
           S  GQ     + A     P A  PP  P        AP  +   PP P      QA  + 
Sbjct: 498 SFPGQAPFSPS-ASLPMSPLATPPPQAPPV----LAAPLLQV--PPSPPASPTLQAPRRP 550

Query: 821 CVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRD---------AGLQVSLGAA--ETR 869
                     P     G   +   AP  P PPSR           AG   S  +   E R
Sbjct: 551 PTP------GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 604

Query: 870 SVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPP 904
              +GP    AA+PP   E+     +A +   APP
Sbjct: 605 GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPP 639



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 65/260 (25%), Positives = 96/260 (36%), Gaps = 22/260 (8%)

Query: 672 PGSCRKAEPLASGKGEPV-SLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRK 730
           PGS R   P+       + + G     P  +      G  +P S  +  P+ +SR     
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP---P 86

Query: 731 ALGSA-RSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAER------SPCPEAAA 783
           A G   R+P     S G V        +T    LGQK L  +  E       +  P+ +A
Sbjct: 87  ASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 146

Query: 784 PPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSF- 842
              G R RD     P   + A       AGT+ G       A  P  P +G   S  S  
Sbjct: 147 LSAGAR-RDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSA-RPRPPTEGPRKSVSSAS 204

Query: 843 QAAPRAPSPPSRR--DAGLQVSLGAAETRSVATGPMT------PQAAAPPAFPEVRVRPG 894
           + +   PSP +RR   AG  +   A+ + S +  P++      P A   P  P    +P 
Sbjct: 205 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 264

Query: 895 SALAAAVAPPEPAEPVRDVS 914
                A+ PP+   P +D +
Sbjct: 265 PKGLQALRPPQVTPPRKDAA 284



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 36/137 (26%), Positives = 50/137 (36%), Gaps = 9/137 (6%)

Query: 16  DSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPS 75
           D+S  GPR T    P       G        PS   + P    H+   +   E      S
Sbjct: 556 DTSVSGPRLTLALAP-------GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 608

Query: 76  GAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSV 135
           G   GA+ S  P   LA   P  +S   +P      A GA +   P AT  G  + + ++
Sbjct: 609 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP-WPPATGPGSADGLCTI 667

Query: 136 -KTEPKSSDDRNPMFLE 151
            +TE   S    P  L+
Sbjct: 668 YETEGPESATPAPGALD 684


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 215/925 (23%), Positives = 307/925 (33%), Gaps = 147/925 (15%)

Query: 16   DSSPPGPR--PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRS 73
            D  PPGP   P AF        G GS+      PS   +SPA    +   S  + S    
Sbjct: 511  DPEPPGPPDPPVAF------GKGYGSA------PSSSASSPASSSASAATSFSLGSGTFK 558

Query: 74   PSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKET--LEAHGASISGTPEATTSGKPEP 131
               +G+G++      G L  P P    P  +PSK T  L    A+       +  G   P
Sbjct: 559  AQESGQGSTA-----GPLRPPPPGAGGPA-TPSKATRFLPMDPATFRRKRPESVGGLEPP 612

Query: 132  VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG 191
              SV   P S        L     K  ++     +      S     P     + P    
Sbjct: 613  GPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPA-APLSRPAATM 671

Query: 192  KGDPVAPGRMDPMTVRKEDLGSLGKVDP----LCSSKTYTVSPRKEDPGSLRKVDPVSSD 247
              + V P    P+ +  +   + G+ +        ++T   +  +   GS   V  V SD
Sbjct: 672  VTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSD 731

Query: 248  KVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDS 307
            K       K     S   H V+   +         +       PG    A P        
Sbjct: 732  K-------KSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQG 784

Query: 308  ASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLD------------PTCLGMAD- 354
            A  G T  G         SG NGPV  G   PG+LG+              P  L +A  
Sbjct: 785  APGGGTTAG---SGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPA 841

Query: 355  ----PASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDP 410
                P +     + PA     RF   + P +S  G+ ++    T       L S+ +  P
Sbjct: 842  PAPAPGTKAAAPSGPAPTTSIRFT--LPPGTSTNGKVLAATAPTPGIPI--LQSVPSAPP 897

Query: 411  MSSGKVDPVSL---GKMDPMCSGKPELLSPGQAERVSVGKAGT------VSPGKEDPVSS 461
              +  V PV     G    +  GK  +L P  A  +SV   G       VSP    PV +
Sbjct: 898  PKAQSVSPVQAPPPGGSAQLLPGK--VLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQN 955

Query: 462  RREDPISAGSRKTSSEKVNPESSGKTNPVSSG--PGDPRSLGTAGPPSAVKAE--PATGG 517
              + P S   + T      P  SG   P+S    PG          PS+ +     + GG
Sbjct: 956  GAQPP-SKIIQLTPVPVSTP--SGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGG 1012

Query: 518  KGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVS 577
               PL +           +P +S      + G    V+ G    GPSG            
Sbjct: 1013 HALPLGT-----------SPASSQAGTVTSYGPTSSVALGFTSLGPSG------------ 1049

Query: 578  TPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQP----- 632
             P    P+       +S G+A  +  G+VG       SPV + +  P  +    P     
Sbjct: 1050 -PAFVQPL-------LSAGQAPLLAPGQVGV------SPVPSPQLPPACAAPGGPVITAF 1095

Query: 633  QSGGKAETK-LPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSL 691
             SG  A T   P  + + AP           TP A+  +  G      P A     P   
Sbjct: 1096 YSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKG------PPAPATATPAP- 1148

Query: 692  GKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPK 751
                  PS    S +   V P   +  +PS  + Q  + A+ S        G+ GR  P 
Sbjct: 1149 --TSPFPSATAGSMTYSLVAP---KAQRPSPKAPQKVKAAIASIPVGSFEAGASGR--PG 1201

Query: 752  AEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAP-PPPRE 810
              P    E   + +     +  E  P P A  PPP P T       P+  +S P PPP E
Sbjct: 1202 PAPRQPLEPGPVREPTAPESELEGQPTPPA--PPPLPETW-----TPTARSSPPLPPPAE 1254

Query: 811  DAGTQAGAQACVSVAVSPMSPQD-GAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETR 869
            +  +  G +   S    P S  D    G     +  P  P+PPS   A      G++E+ 
Sbjct: 1255 ERTSAKGPETMAS--KFPSSSSDWRVPGQGLENRGEP--PTPPSPAPAPAVAPGGSSESS 1310

Query: 870  SVATGPMTPQ-AAAPPAFPEVRVRP 893
            S      TP+   A     +V+VRP
Sbjct: 1311 SGRAAGDTPERKEAAGTGKKVKVRP 1335



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 192/855 (22%), Positives = 280/855 (32%), Gaps = 136/855 (15%)

Query: 156 KSSKQADSTSIGKE-DPGSSRKADPMFT-GKAEPEILGKGDP-----VAPGRMDPMTVRK 208
           +S + A+S ++  E  PG +  ADP    G   PE  G G P     V  G+  P T  +
Sbjct: 70  QSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEE 129

Query: 209 EDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPV 268
           E  G  G  +P   S+T +      D   L  + P     + P   R +      KE   
Sbjct: 130 EASGPPG--EPRLDSETES----DHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDS 183

Query: 269 SSEKV--APTSAEKVDL-------VLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLG 319
           SSEK   +P   EK  +       ++  KR      +  P    + D+ +  K       
Sbjct: 184 SSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHP----NQDNRTVSKILGEWWY 239

Query: 320 KLIPGSSGKNGPVS----------------SGTGAPGSLGRLDPTCLGMAD------PAS 357
            L P    K   ++                       S     PT LG+A         S
Sbjct: 240 ALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERS 299

Query: 358 VGNVETVPATKEDSRFLG----------KMDPASSGEGRPVSGHTDTTASAKTDLTSLKN 407
           +    T  A    S  L              P SS  G           SA+    S   
Sbjct: 300 MSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFSHSG 359

Query: 408 VDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGT-VSPGKEDPVSSRREDP 466
           V  +  G+VD  +L ++  M SG      P  +     G  G   +PG+   +++    P
Sbjct: 360 VHSLDGGEVDSQALQELTQMVSGPASYSGPKPS--TQYGAPGPFAAPGEGGALAATGRPP 417

Query: 467 I----SAGSRKTSSEKVNPESSGKTNPVSSGPGD---PRSLGTAGPPSAVKAEPATGGKG 519
           +    ++ S++ +SE +  +          G  D       GT       K        G
Sbjct: 418 LLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESG 477

Query: 520 DPLSSEKAGLVASGKA--APTASGK-------AEPLAVGKED-PVSKGKA-DAGPSGQGD 568
           D    +  G    G+   +P             +P   G  D PV+ GK   + PS    
Sbjct: 478 DSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSAS 537

Query: 569 SVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKA------ 622
           S +     ++   +  + SG       G+      G +   P   G P T +KA      
Sbjct: 538 SPASSS--ASAATSFSLGSGTFKAQESGQGST--AGPLRPPPPGAGGPATPSKATRFLPM 593

Query: 623 DPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKK-ETPQASEKVDPGSCRKAEPL 681
           DP    + +P+S G  E   PG    AAP   G   L+    P   E+ + G  R    +
Sbjct: 594 DPATFRRKRPESVGGLEP--PGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGAR----V 647

Query: 682 ASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGA 741
            S     ++ G   +  SR   +     V P+S      +S       +A  S     GA
Sbjct: 648 PSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGA 707

Query: 742 R---GSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPP------PGPRTRD 792
           R   G+  RV     P  S    SL   D ++A A  SP P   A P        P T  
Sbjct: 708 RTEMGTGSRV-----PGGSPLGVSLVYSDKKSAAA-TSPAPHLVAGPLLGTVGKAPATVT 761

Query: 793 N-FTKAPSWEASAPPPPR------EDAGTQAGAQACVSVAVSPMSP------QDGAGGSA 839
           N     P + A APP  +         GT AG+ A       P  P      Q GA G A
Sbjct: 762 NLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGA--GAGSGPNGPVPLGILQPGALGKA 819

Query: 840 FSF-QAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSAL- 897
               Q     P+ P       Q+ +  A   +  T    P   AP       + PG++  
Sbjct: 820 GGITQVQYILPTLPQ------QLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTN 873

Query: 898 --AAAVAPPEPAEPV 910
               A   P P  P+
Sbjct: 874 GKVLAATAPTPGIPI 888



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 192/920 (20%), Positives = 309/920 (33%), Gaps = 135/920 (14%)

Query: 14   QKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQK-ASPAPP--RHTPDQSPGMESR 70
            +K ++   P P     P  G++G   + + +         +PAPP  +     +PG  + 
Sbjct: 732  KKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTT 791

Query: 71   HRSPSGAGEGAS-------CSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEA 123
              S +GAG G +          G  G     +   +     P +  +    A   GT  A
Sbjct: 792  AGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAA 851

Query: 124  TTSGKPEPVSSVK-TEPKSSDDRNPMF-----------LEKMDFKSSKQADSTS-IGKED 170
              SG P P +S++ T P  +     +            L+ +      +A S S +    
Sbjct: 852  APSG-PAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPP 910

Query: 171  PGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSK-TYTVS 229
            PG S +  P             G  + P     M+VR    G  G+  PL S   +  V 
Sbjct: 911  PGGSAQLLP-------------GKVLVPLAAPSMSVRG---GGAGQPLPLVSPPFSVPVQ 954

Query: 230  PRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSS-EKVAPTSAEKVDLVLSGK 288
               + P  + ++ PV       + P        G   P S  +KV   S+ ++  V S  
Sbjct: 955  NGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPG---PTSQPQKVLLPSSTRITYVQSAG 1011

Query: 289  RDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK---NGPVSSGTG---APGSL 342
                P G + P   ++    S G T    LG    G SG       +S+G     APG +
Sbjct: 1012 GHALPLGTS-PASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQV 1070

Query: 343  G-------RLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTT 395
            G       +L P C     P         PA    +       P+ +      +  T TT
Sbjct: 1071 GVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLA---QPSQAPPSLVYTVATSTT 1127

Query: 396  ASAKTDLT----SLKNVDPMSSGKVDPVSLGKMD-PMCSGKPELLSPGQAERVSVGKA-- 448
              A T L     +     P  +      + G M   + + K +  SP   ++V    A  
Sbjct: 1128 PPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASI 1187

Query: 449  --GTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGT---- 502
              G+   G           P+  G  +   E   PES  +  P    P       T    
Sbjct: 1188 PVGSFEAGASGRPGPAPRQPLEPGPVR---EPTAPESELEGQPTPPAPPPLPETWTPTAR 1244

Query: 503  AGPPSAVKAEPATGGKGDPLSSEK------------AGLVASGKA-APTASGKAEPLAVG 549
            + PP    AE  T  KG    + K             GL   G+   P +   A  +A G
Sbjct: 1245 SSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPG 1304

Query: 550  KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
                 S G+A      + ++   GK V      +      VD   L + +   E +   L
Sbjct: 1305 GSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDF--EERFAEL 1362

Query: 610  PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
            P  +   V  +      +   +   G   + +    +  +AP          E P + ++
Sbjct: 1363 PEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAP----------EDPTSPKR 1412

Query: 670  VDPGSCRKAEPLASGKGEPVSLG-KADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLD 728
                  R+    +S    P S   + D     +T + +   +  L  +K   SS  R LD
Sbjct: 1413 ----KMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLD 1468

Query: 729  -RKAL-----------GSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERS 776
             R+AL            SA++    +     + P ++     +   + QK ++AA     
Sbjct: 1469 QRRALVMQLFQDHGFFPSAQATAAFQARYADIFP-SKVCLQLKIREVRQKIMQAATPTEQ 1527

Query: 777  PCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAG----TQAGAQACVSVAVSPMSPQ 832
            P P A AP P P         P+  A+AP P    AG    T   + +  + A  P+ P 
Sbjct: 1528 P-PGAEAPLPVP--------PPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPP 1578

Query: 833  DGAGGSAFSFQAAPRAPSPP 852
              +G     ++ AP+ PSPP
Sbjct: 1579 PESGPGQPGWEGAPQ-PSPP 1597



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 154/689 (22%), Positives = 235/689 (34%), Gaps = 126/689 (18%)

Query: 370 DSRFLGKMDPASSGEGRPVS-----GHTDT---------TASAKTDLTSLKNVDPMSSGK 415
           D ++  K    SS E +P S     GH +T         TA+A    + L +V   +   
Sbjct: 266 DWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLS 325

Query: 416 VDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAG--TVSPGKEDPVSSRREDPISAGSRK 473
            D  + G           +  PG A   +   +G  ++  G+ D  + +    + +G   
Sbjct: 326 SDTKAPGSSSCGAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPAS 385

Query: 474 TSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAV--KAEPATGGKGDPLSSEKAGLVA 531
            S  K + +  G   P ++ PG+  +L   G P  +  +A  +     + ++S++  +V 
Sbjct: 386 YSGPKPSTQY-GAPGPFAA-PGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVI 443

Query: 532 ------------SGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVST- 578
                        G        K +      E   S G+   G  G G  V    + S+ 
Sbjct: 444 CEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSF 503

Query: 579 ---PGKTVPVPSGKVDP-VSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQS 634
                   P P G  DP V+ GK          S P    +   T+ +    + KAQ   
Sbjct: 504 THCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESG 563

Query: 635 GGKAETKL----PGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVS 690
            G     L    PG  G A P +A               +DP + R+  P + G  EP  
Sbjct: 564 QGSTAGPLRPPPPGAGGPATPSKATRFL----------PMDPATFRRKRPESVGGLEP-- 611

Query: 691 LGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEP 750
                  PS     PS G  +  +L    P+   ++     + SA +P  A G+      
Sbjct: 612 -----PGPSVIAAPPSGGGNILQTLV-LPPNKEEQEGGGARVPSAPAPSLAYGAP----- 660

Query: 751 KAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPRE 810
            A P+S   A+ +            +P P A+ P P            S  A A P    
Sbjct: 661 -AAPLSRPAATMVTNV---VRPVSSTPVPIASKPFP-----------TSGRAEASPNDTA 705

Query: 811 DAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGL---QVSLGAAE 867
            A T+ G  + V    SP+          +S + +  A SP     AG     V    A 
Sbjct: 706 GARTEMGTGSRVPGG-SPLGVS-----LVYSDKKSAAATSPAPHLVAGPLLGTVGKAPAT 759

Query: 868 TRSVATGPMTPQAAAPPAF-------PEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGM 920
             ++  G     A APPA        P      GS   A   P  P  P+  +     G 
Sbjct: 760 VTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPV-PLGILQPGALGK 818

Query: 921 TWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPA------ARAGPGRSGSVRTA 974
                G   +V+ +   + + L         Q APAP PA      A +GP  + S+R  
Sbjct: 819 A----GGITQVQYILPTLPQQL---------QVAPAPAPAPGTKAAAPSGPAPTTSIRFT 865

Query: 975 PPDG--------AAKRP-PGLFRALLQSV 994
            P G        AA  P PG+   +LQSV
Sbjct: 866 LPPGTSTNGKVLAATAPTPGI--PILQSV 892



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 97/409 (23%), Positives = 143/409 (34%), Gaps = 88/409 (21%)

Query: 435 LSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK-------VNPESS-GK 486
           L+P Q +  SV  +    P      S++ ++P  A S   + E+        +PE   G 
Sbjct: 44  LAPSQPDP-SVQPSEAQQPASHPVASNQSKEP--AESAAVAHERPPGGTGSADPERPPGA 100

Query: 487 TNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPL 546
           T P S GPG P  LG               GKG P ++E+    ASG             
Sbjct: 101 TCPESPGPGPPHPLGV-----------VESGKGPPPTTEEE---ASG------------- 133

Query: 547 AVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKV 606
                 P  + + D+      D   +   + +P   +P+P GK    SL    A+P+ + 
Sbjct: 134 ------PPGEPRLDSETESDHDDAFLS--IMSPEIQLPLPPGKRRTQSL---SALPKERD 182

Query: 607 GSLPLEKGSPVTTTKADPRASGKA---------------QPQSGGKAETKLPGQEG-AAA 650
            S   +  SP    K   R    A                P    +  +K+ G+   A  
Sbjct: 183 SSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALG 242

Query: 651 PGEAGAV-CLKKETPQASEKVDPG--SCRKAEPLASGKGEPVSLGKADSAPSRKTESPS- 706
           P E      L  +  +A  K  P    C K    +S + +P SLG A      +  S S 
Sbjct: 243 PKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSE 302

Query: 707 LGKVVPLSLEKTKPSSSSRQL---DRKALGSARSPEGAR-----GSEGRVEPKAEPVSST 758
            G      +     S +++ L   D KA GS  S  GA      G  G   P+A   S  
Sbjct: 303 TGTAAAPGVSSELLSVAAQTLLSSDTKAPGS--SSCGAERLHTVGGPGSARPRAFSHSGV 360

Query: 759 EASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPP 807
            +   G+ D +A   E +      A   GP+        PS +  AP P
Sbjct: 361 HSLDGGEVDSQAL-QELTQMVSGPASYSGPK--------PSTQYGAPGP 400


>gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1230

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 112/441 (25%), Positives = 160/441 (36%), Gaps = 37/441 (8%)

Query: 468 SAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKA 527
           S  S  + S   +  +SG + P +SG   P + G + P  +  A P+  G   P +S  A
Sbjct: 10  SGVSTPSGSGWASSSASGASTPSNSGWASPSASGASIPSDSGWASPSASGASTPSNSGWA 69

Query: 528 GLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPS 587
              AS  + P+ SG A P A     P   G   A PS  G S+      S  G   P  S
Sbjct: 70  SFSASWASIPSDSGWASPSASWASTPSDSGW--ASPSASGASIP-----SDSGWASPSVS 122

Query: 588 GKVDPVSLGKAEAIPEGKVGSLPLEKG--SPVTTTKADPRASGKAQPQ---SGGKAETKL 642
           G   P +     A P     S P + G  SP  +  +    SG A P    +   A    
Sbjct: 123 GASIPSAFW---ASPSASGASTPSDSGWASPSASWASTSSDSGWASPSASWTSPSASCAS 179

Query: 643 PGQEGAAAPGEAG-----AVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSA 697
               GA+ P ++G        +   T  AS   D G    + P  SG     +   + SA
Sbjct: 180 SSASGASTPSDSGWASPSVFWVSPSTSWASSPSDFGWA--STPSDSGWASSSASCISPSA 237

Query: 698 PSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSS 757
               T S S       S   T  S +S   D     S+ S +      G V P A   SS
Sbjct: 238 SGASTSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWVCPSASWASS 297

Query: 758 TEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAG 817
           +           A+ A       +++P     +  + +   S+ AS    P +   T   
Sbjct: 298 S-----------ASWASAPSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHS 346

Query: 818 AQACVSVAVSP-MSPQ-DGAGGSAFSFQAAPRAP-SPPSRRDAGLQVSLG-AAETRSVAT 873
           A    + + S   SP   GA  S+ S  A+P A  + PS   A      G A+ + S A+
Sbjct: 347 ASGVSTTSDSGWASPSASGASTSSDSGWASPSASWASPSASGASTPSDSGWASPSASGAS 406

Query: 874 GPMTPQAAAPPAFPEVRVRPG 894
            P  P       FP++  R G
Sbjct: 407 MPSAPSLCPGSCFPQLTARTG 427



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 94/404 (23%), Positives = 137/404 (33%), Gaps = 36/404 (8%)

Query: 243 PVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPL 302
           P +S    P       P  SG   P +S    P+++       S    P  SG A P   
Sbjct: 31  PSNSGWASPSASGASIPSDSGWASPSASGASTPSNSGWASFSASWASIPSDSGWASPSAS 90

Query: 303 ESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVE 362
            +   + +G   P   G  IP  SG   P  SG   P +     P+  G + P+  G   
Sbjct: 91  WASTPSDSGWASPSASGASIPSDSGWASPSVSGASIPSAFW-ASPSASGASTPSDSGWAS 149

Query: 363 TVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTD------LTSLKNVDPMSSGKV 416
              +    S   G   P++S      S  + + + A T         S+  V P +S   
Sbjct: 150 PSASWASTSSDSGWASPSASWTSPSASCASSSASGASTPSDSGWASPSVFWVSPSTSWAS 209

Query: 417 DPVSLG-KMDPMCSG----KPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGS 471
            P   G    P  SG        +SP  +   +   +G  SP       S      S   
Sbjct: 210 SPSDFGWASTPSDSGWASSSASCISPSASGASTSSDSGWASP-------SASWVSTSTSR 262

Query: 472 RKTSSEKVNPESSGKTNPVSSGPG-DPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLV 530
             TSS+     SS   + ++S  G    S   A   ++  + P+  G   P  S  + L 
Sbjct: 263 ASTSSDSGWASSSASWDSITSDSGWVCPSASWASSSASWASAPSDSGSSSPSVSRASTLS 322

Query: 531 ASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
            SG A+ +ASG + P   G     + G +    SG           S  G +    SG  
Sbjct: 323 VSGWASFSASGASAPSDSGWTSHSASGVSTTSDSGWASP-------SASGASTSSDSGWA 375

Query: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQS 634
            P     + A P     S P + G       A P ASG + P +
Sbjct: 376 SP---SASWASPSASGASTPSDSG------WASPSASGASMPSA 410



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 97/426 (22%), Positives = 137/426 (32%), Gaps = 26/426 (6%)

Query: 286 SGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRL 345
           SG   P  SG A      +   +++G   P   G  IP  SG   P +SG   P + G  
Sbjct: 10  SGVSTPSGSGWASSSASGASTPSNSGWASPSASGASIPSDSGWASPSASGASTPSNSGWA 69

Query: 346 DPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSL 405
             +    + P+  G      +        G   P++SG   P      + + +   + S 
Sbjct: 70  SFSASWASIPSDSGWASPSASWASTPSDSGWASPSASGASIPSDSGWASPSVSGASIPSA 129

Query: 406 KNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRRED 465
               P +SG   P   G   P  S        G A         + S     P +S    
Sbjct: 130 FWASPSASGASTPSDSGWASPSASWASTSSDSGWA---------SPSASWTSPSASCASS 180

Query: 466 PISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSE 525
             S  S  + S   +P S    +P +S    P   G A  PS      ++     P    
Sbjct: 181 SASGASTPSDSGWASP-SVFWVSPSTSWASSPSDFGWASTPSDSGWASSSASCISP---- 235

Query: 526 KAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPV 585
                ASG +  + SG A P A       S+    +       S S   + S  G   P 
Sbjct: 236 ----SASGASTSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWVCPS 291

Query: 586 PSGKVDPVSLGKAEAIPEGKVGSLP-LEKGSPVTTTK-ADPRASGKAQPQSGGKAETKLP 643
            S      S   A   P     S P + + S ++ +  A   ASG + P   G       
Sbjct: 292 ASWASSSASWASA---PSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHSAS 348

Query: 644 GQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKT- 702
           G    +  G A        T   S    P S   A P ASG   P   G A  + S  + 
Sbjct: 349 GVSTTSDSGWASPSASGASTSSDSGWASP-SASWASPSASGASTPSDSGWASPSASGASM 407

Query: 703 -ESPSL 707
             +PSL
Sbjct: 408 PSAPSL 413



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 95/423 (22%), Positives = 139/423 (32%), Gaps = 32/423 (7%)

Query: 259 PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLL 318
           P  SG     +S    P+++       SG   P  SG A P    +   +++G       
Sbjct: 15  PSGSGWASSSASGASTPSNSGWASPSASGASIPSDSGWASPSASGASTPSNSGWASFSAS 74

Query: 319 GKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPA-------SVGNVETVPATKEDS 371
              IP  SG   P +S    P   G   P+  G + P+       SV       A     
Sbjct: 75  WASIPSDSGWASPSASWASTPSDSGWASPSASGASIPSDSGWASPSVSGASIPSAFWASP 134

Query: 372 RFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSG- 430
              G   P+ SG   P +    T++ +     S     P +S      S G   P  SG 
Sbjct: 135 SASGASTPSDSGWASPSASWASTSSDSGWASPSASWTSPSASCASSSAS-GASTPSDSGW 193

Query: 431 -KPEL--LSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKT 487
             P +  +SP  +   S    G  S             P  +G   +S+  ++P +SG +
Sbjct: 194 ASPSVFWVSPSTSWASSPSDFGWAS------------TPSDSGWASSSASCISPSASGAS 241

Query: 488 NPVSSGPGDPRSLGTAGPPSAVKAEPATG-----GKGDPLSSEKAGLVASGK-AAPTASG 541
               SG   P +   +   S       +G        D ++S+   +  S   A+ +AS 
Sbjct: 242 TSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWVCPSASWASSSASW 301

Query: 542 KAEPLAVGKEDPVSKGKADAGPSGQGD-SVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEA 600
            + P   G   P     +    SG    S S     S  G T    SG       G A  
Sbjct: 302 ASAPSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHSASGVSTTSDSGWASP 361

Query: 601 IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK 660
              G   S      SP + + A P ASG + P   G A     G    +AP      C  
Sbjct: 362 SASGASTSSDSGWASP-SASWASPSASGASTPSDSGWASPSASGASMPSAPSLCPGSCFP 420

Query: 661 KET 663
           + T
Sbjct: 421 QLT 423


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.126    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,364,125
Number of Sequences: 37866
Number of extensions: 3387881
Number of successful extensions: 22249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 1610
Number of HSP's that attempted gapping in prelim test: 13204
Number of HSP's gapped (non-prelim): 7268
length of query: 1008
length of database: 18,247,518
effective HSP length: 112
effective length of query: 896
effective length of database: 14,006,526
effective search space: 12549847296
effective search space used: 12549847296
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.