Guide to the Human Genome
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Search of human proteins with 17158041

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
         (879 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]           1748   0.0  
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]           1708   0.0  
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]           1708   0.0  
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]           1702   0.0  
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]            1126   0.0  
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]            894   0.0  
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]            894   0.0  
gi|153085395 histone deacetylase 4 [Homo sapiens]                     875   0.0  
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]           438   e-122
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]           417   e-116
gi|13128864 histone deacetylase 6 [Homo sapiens]                      155   2e-37
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]          140   7e-33
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]           140   7e-33
gi|13128860 histone deacetylase 1 [Homo sapiens]                       77   7e-14
gi|116284376 histone deacetylase 2 [Homo sapiens]                      75   2e-13
gi|8923769 histone deacetylase 8 [Homo sapiens]                        74   5e-13
gi|13128862 histone deacetylase 3 [Homo sapiens]                       66   1e-10
gi|221139761 zinc finger protein 853 [Homo sapiens]                    59   2e-08
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      56   2e-07
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      56   2e-07
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       56   2e-07
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       56   2e-07
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   55   3e-07
gi|148746195 trichohyalin [Homo sapiens]                               54   6e-07
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      54   6e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    52   2e-06
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    52   2e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    52   2e-06
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 52   3e-06
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]           51   4e-06

>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
          Length = 879

 Score = 1748 bits (4527), Expect = 0.0
 Identities = 879/879 (100%), Positives = 879/879 (100%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120

Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
           EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180

Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
           HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240

Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
           PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300

Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
           EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360

Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
           GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420

Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
           QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480

Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
           QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540

Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
           QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600

Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
           EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660

Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
           IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720

Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
           DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780

Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
           GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840

Query: 841 SLHRYDEGNFFPGSGAPNEVRFISLEPHFYLYLSGNCIA 879
           SLHRYDEGNFFPGSGAPNEVRFISLEPHFYLYLSGNCIA
Sbjct: 841 SLHRYDEGNFFPGSGAPNEVRFISLEPHFYLYLSGNCIA 879


>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
          Length = 1011

 Score = 1708 bits (4423), Expect = 0.0
 Identities = 860/860 (100%), Positives = 860/860 (100%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120

Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
           EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180

Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
           HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240

Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
           PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300

Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
           EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360

Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
           GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420

Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
           QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480

Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
           QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540

Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
           QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600

Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
           EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660

Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
           IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720

Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
           DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780

Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
           GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840

Query: 841 SLHRYDEGNFFPGSGAPNEV 860
           SLHRYDEGNFFPGSGAPNEV
Sbjct: 841 SLHRYDEGNFFPGSGAPNEV 860


>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
          Length = 1066

 Score = 1708 bits (4423), Expect = 0.0
 Identities = 860/860 (100%), Positives = 860/860 (100%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120

Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
           EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180

Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
           HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240

Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
           PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300

Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
           EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360

Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
           GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420

Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
           QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480

Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
           QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540

Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
           QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600

Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
           EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660

Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
           IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720

Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
           DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780

Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
           GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840

Query: 841 SLHRYDEGNFFPGSGAPNEV 860
           SLHRYDEGNFFPGSGAPNEV
Sbjct: 841 SLHRYDEGNFFPGSGAPNEV 860


>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
          Length = 1069

 Score = 1702 bits (4409), Expect = 0.0
 Identities = 860/863 (99%), Positives = 860/863 (99%), Gaps = 3/863 (0%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
           KQLLIAEFQKQHENLTRQHQAQLQEHIK   ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120

Query: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
           HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180

Query: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
           TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240

Query: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
           RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300

Query: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
           PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360

Query: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
           LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420

Query: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
           LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480

Query: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
           YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540

Query: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597
           TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600

Query: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657
           DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660

Query: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717
           AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720

Query: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777
           LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780

Query: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837
           RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840

Query: 838 LYISLHRYDEGNFFPGSGAPNEV 860
           LYISLHRYDEGNFFPGSGAPNEV
Sbjct: 841 LYISLHRYDEGNFFPGSGAPNEV 863


>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
          Length = 590

 Score = 1126 bits (2913), Expect = 0.0
 Identities = 574/574 (100%), Positives = 574/574 (100%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120

Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
           EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180

Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
           HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240

Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
           PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300

Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
           EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360

Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
           GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420

Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
           QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480

Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
           QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540

Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574
           QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score =  894 bits (2309), Expect = 0.0
 Identities = 510/908 (56%), Positives = 634/908 (69%), Gaps = 70/908 (7%)

Query: 1   MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
           +HS+  +V+VK  +P  +            SP++LR  L   +  VDP +RE+QLQQELL
Sbjct: 26  LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82

Query: 52  LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
            ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K   E+LA KQQQE+L  +++Q+L
Sbjct: 83  ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142

Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
           EQQRQ     ++E+E+ R EQQL  LR K++ +E A+ASTEVK +LQEFLLSKS  K+  
Sbjct: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200

Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
             G NHS+ +HPK W   AHH SLDQSSPP SG   T PSYK  LPG  D++DDFPLRKT
Sbjct: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258

Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
           ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR  E+T      SSV +S+PGS
Sbjct: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318

Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
           GPSSPN+  +       T  +P  P   +M+ Q R L  + S N  SLYTSPSLPNI+LG
Sbjct: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376

Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
           L A      S L AS  L  +Q+ E Q   +LRQG  L G++  +         V LEG 
Sbjct: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436

Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
                H +LLQH+LL EQ RQQ  L+A  VPLH QSPL T ER++  +R   KLPRHRPL
Sbjct: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494

Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
           +RTQS+PLPQS   L QLV+QQQHQQFLEKQKQ  QQ+ + K+L+K+ E  +QP +H EE
Sbjct: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552

Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
            EEEL        G+ A+   R  S+   ST+ D       DD   +   ++VK+E  +S
Sbjct: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612

Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
             +E   ++E  +G +  F     L+P     L V QAPL+   +     H+ + RT SS
Sbjct: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663

Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
           PAA        D+P++    TG+ YD  MLKHQC+CGN+  HPEHAGRIQSIWSRLQETG
Sbjct: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723

Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
           LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG  SQK ++ LPCG
Sbjct: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783

Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
           G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843

Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
           CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903

Query: 853 GSGAPNEV 860
           GSGAP EV
Sbjct: 904 GSGAPEEV 911


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score =  894 bits (2309), Expect = 0.0
 Identities = 510/908 (56%), Positives = 634/908 (69%), Gaps = 70/908 (7%)

Query: 1   MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
           +HS+  +V+VK  +P  +            SP++LR  L   +  VDP +RE+QLQQELL
Sbjct: 25  LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81

Query: 52  LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
            ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K   E+LA KQQQE+L  +++Q+L
Sbjct: 82  ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141

Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
           EQQRQ     ++E+E+ R EQQL  LR K++ +E A+ASTEVK +LQEFLLSKS  K+  
Sbjct: 142 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199

Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
             G NHS+ +HPK W   AHH SLDQSSPP SG   T PSYK  LPG  D++DDFPLRKT
Sbjct: 200 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257

Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
           ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR  E+T      SSV +S+PGS
Sbjct: 258 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317

Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
           GPSSPN+  +       T  +P  P   +M+ Q R L  + S N  SLYTSPSLPNI+LG
Sbjct: 318 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375

Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
           L A      S L AS  L  +Q+ E Q   +LRQG  L G++  +         V LEG 
Sbjct: 376 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435

Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
                H +LLQH+LL EQ RQQ  L+A  VPLH QSPL T ER++  +R   KLPRHRPL
Sbjct: 436 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493

Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
           +RTQS+PLPQS   L QLV+QQQHQQFLEKQKQ  QQ+ + K+L+K+ E  +QP +H EE
Sbjct: 494 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551

Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
            EEEL        G+ A+   R  S+   ST+ D       DD   +   ++VK+E  +S
Sbjct: 552 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611

Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
             +E   ++E  +G +  F     L+P     L V QAPL+   +     H+ + RT SS
Sbjct: 612 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662

Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
           PAA        D+P++    TG+ YD  MLKHQC+CGN+  HPEHAGRIQSIWSRLQETG
Sbjct: 663 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722

Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
           LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG  SQK ++ LPCG
Sbjct: 723 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782

Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
           G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 783 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842

Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
           CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 843 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902

Query: 853 GSGAPNEV 860
           GSGAP EV
Sbjct: 903 GSGAPEEV 910


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score =  875 bits (2262), Expect = 0.0
 Identities = 495/885 (55%), Positives = 617/885 (69%), Gaps = 54/885 (6%)

Query: 1   MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
           ++ M S+VDV + +P+ + P + P+DLR D +  +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 25  VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84

Query: 60  QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
           Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK   E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 85  QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144

Query: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
           +  REQ+L  L+ K++G+E AVASTEVK KLQEF+L+K   K       NH +S  P+ W
Sbjct: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202

Query: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
           Y    H+SLDQSSPP SG S SY + + G  DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262

Query: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
           RRSSPLLRRKDG VVT+ KKR  +VT+S+ SS+ PGSGPSSPNN       EN  +   P
Sbjct: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321

Query: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356
           +  AE  ++  R++  E S   L LYTSPSLPNITLGLPA       +   ++ ++    
Sbjct: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379

Query: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414
            L+Q + L PG +    P  S+ P   LE +   ++H  LLQH++L EQ   Q  LV G 
Sbjct: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433

Query: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471
             +PLH QS L   +R+SP I   HKL +HRPL RTQSAPLPQ+   L  LVIQQQHQQF
Sbjct: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489

Query: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525
           LEK KQ   QQQ+ MNK++ K  E  +QP SH EE EEEL+  QA+ +    DR P    
Sbjct: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547

Query: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577
                      +   Q G V+VK+EP++SDE+           Q   S ++  F QQ  L
Sbjct: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596

Query: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635
            E      L   QA + A G+      HR +SR  SSPA++  P    + P +P   TG+
Sbjct: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656

Query: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695
            YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL  KCE I+GRKA+LEE+Q VHS
Sbjct: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716

Query: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755
           E H+LLYGTNPL+ QKLD + LLG  +  F   LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775

Query: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815
           GCV+EL  KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835

Query: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 860
           IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EV
Sbjct: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEV 880


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score =  438 bits (1126), Expect = e-122
 Identities = 329/813 (40%), Positives = 418/813 (51%), Gaps = 112/813 (13%)

Query: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115

Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191
             AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175

Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251
           +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222

Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308
            S ++R  E     S  SSS+P SG SSPN+   G           P P    + +  QR
Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271

Query: 309 ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363
           + + E S+   +L T   LP ITLGLPA P++ ++              L  G P     
Sbjct: 272 LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328

Query: 364 ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419
               L  + GG++P S   P + L+   P+ SH  LL    L            G +P H
Sbjct: 329 LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372

Query: 420 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479
               L T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + 
Sbjct: 373 FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424

Query: 480 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539
           Q      ++ +S +  ++P      + E+L+ D                      VDD L
Sbjct: 425 Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463

Query: 540 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599
                   +E      E      ++   Q    +Q  L     R  S     L  +   G
Sbjct: 464 EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516

Query: 600 LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647
              HR +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC 
Sbjct: 517 ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573

Query: 648 CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707
           CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL
Sbjct: 574 CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633

Query: 708 DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767
              KLD   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS
Sbjct: 634 SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693

Query: 768 GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827
            ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGT
Sbjct: 694 RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753

Query: 828 QQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 860
           QQ FY DPS+LYISLHR+D+GNFFPGSGA +EV
Sbjct: 754 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEV 786


>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
          Length = 954

 Score =  417 bits (1071), Expect = e-116
 Identities = 319/805 (39%), Positives = 399/805 (49%), Gaps = 133/805 (16%)

Query: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115

Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191
             AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175

Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251
           +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222

Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309
            S ++R  E     S  SSS+P SG SSPN+   G           P P         R 
Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270

Query: 310 LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367
                        T P+L      LG P  P  L                      L  +
Sbjct: 271 ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299

Query: 368 YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427
            GG++P S   P + L+   P+ SH  LL    L            G +P H    L T 
Sbjct: 300 AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343

Query: 428 ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487
           ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q      +
Sbjct: 344 ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389

Query: 488 LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547
           + +S +  ++P      + E+L+ D                      VDD L        
Sbjct: 390 IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428

Query: 548 KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607
           +E      E      ++   Q    +Q  L     R  S     L  +   G   HR +S
Sbjct: 429 RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484

Query: 608 RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655
           R  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HP
Sbjct: 485 RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544

Query: 656 EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715
           EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD  
Sbjct: 545 EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604

Query: 716 ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775
            L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA
Sbjct: 605 KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664

Query: 776 VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835
           VVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DP
Sbjct: 665 VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724

Query: 836 SILYISLHRYDEGNFFPGSGAPNEV 860
           S+LYISLHR+D+GNFFPGSGA +EV
Sbjct: 725 SVLYISLHRHDDGNFFPGSGAVDEV 749


>gi|13128864 histone deacetylase 6 [Homo sapiens]
          Length = 1215

 Score =  155 bits (391), Expect = 2e-37
 Identities = 101/252 (40%), Positives = 132/252 (52%), Gaps = 31/252 (12%)

Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
           P   +L  P +       S TG+ YD  M+ H C   +S  HPE   RI  I  RL+E G
Sbjct: 467 PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518

Query: 673 LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 731
           L  +C  +  R A+  E+   HS E+   L  T  +  ++L        +S  F S   C
Sbjct: 519 LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572

Query: 732 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 791
                          +   A++A G    L   V SGE+ NG AVVRPPGHHAE+  A G
Sbjct: 573 PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619

Query: 792 FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 850
           FCFFNSVA+ A++ +    +  +ILIVD DVHHGNGTQ  F  DPS+LY+SLHRYD G F
Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679

Query: 851 FP--GSGAPNEV 860
           FP    GA +++
Sbjct: 680 FPMGDEGASSQI 691



 Score =  149 bits (376), Expect = 1e-35
 Identities = 85/229 (37%), Positives = 127/229 (55%), Gaps = 22/229 (9%)

Query: 631 SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 690
           + TG+  D  + +  C+  +S   PE   R+ +I  +L + GLL++C   Q R A  EE+
Sbjct: 84  AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141

Query: 691 QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 749
            LVHS E+  L+  T  ++  +L  R+L                     D+++   +S  
Sbjct: 142 MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182

Query: 750 AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 809
            A +A G V+ L   V   E++NG A++RPPGHHA+ S   G+C FN VA+ A+Y + + 
Sbjct: 183 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242

Query: 810 NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN 858
            I ++LIVD DVHHG GTQ  F  DPS+LY S+HRY++G F+P   A N
Sbjct: 243 RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASN 291


>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score =  140 bits (352), Expect = 7e-33
 Identities = 80/221 (36%), Positives = 117/221 (52%), Gaps = 20/221 (9%)

Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
           T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
           VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 63  VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103

Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
           R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163

Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
            +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score =  140 bits (352), Expect = 7e-33
 Identities = 80/221 (36%), Positives = 117/221 (52%), Gaps = 20/221 (9%)

Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
           T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
           VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 63  VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103

Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
           R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163

Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
            +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204


>gi|13128860 histone deacetylase 1 [Homo sapiens]
          Length = 482

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 59/212 (27%), Positives = 92/212 (43%), Gaps = 40/212 (18%)

Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 709
           HP    RI+   + L   GL  K E  +  KA+ EE+   HS+ +     +    N  + 
Sbjct: 28  HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87

Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
            K   R  +G+D   F     F  L  GG                           +AS 
Sbjct: 88  SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121

Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823
           V   + +   AV    G HHA++S A GFC+ N + +    L       ++L +D+D+HH
Sbjct: 122 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179

Query: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855
           G+G ++AFY    ++ +S H+Y  G +FPG+G
Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTG 209


>gi|116284376 histone deacetylase 2 [Homo sapiens]
          Length = 582

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 58/211 (27%), Positives = 89/211 (42%), Gaps = 38/211 (18%)

Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709
           HP    RI+   + L   GL  K E  +  KA+ EE+   HS+ +      +   N  + 
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182

Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
            K   R  +G+D   F     F  L  GG  V      N   +  A   A G        
Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234

Query: 765 VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 824
                            HHA++S A GFC+ N + +    L       ++L +D+D+HHG
Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275

Query: 825 NGTQQAFYADPSILYISLHRYDEGNFFPGSG 855
           +G ++AFY    ++ +S H+Y  G +FPG+G
Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTG 304


>gi|8923769 histone deacetylase 8 [Homo sapiens]
          Length = 377

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 66/245 (26%), Positives = 116/245 (47%), Gaps = 35/245 (14%)

Query: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679
           M+ P +P  + G +  P+ +   ++  +C +    P+ A  + S+   ++   L  +   
Sbjct: 1   MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56

Query: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737
           ++ + AS+EE+   H++ +           Q L      GDD           GLG D  
Sbjct: 57  VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103

Query: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795
            ++ I++   + G A + A  C+I+   KVA      G+       HHA++  A GFC+ 
Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155

Query: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855
           N   +    LR +    +IL VDLD+HHG+G + AF     ++ +SLH++  G FFPG+G
Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212

Query: 856 APNEV 860
             ++V
Sbjct: 213 DVSDV 217


>gi|13128862 histone deacetylase 3 [Homo sapiens]
          Length = 428

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 33/80 (41%), Positives = 49/80 (61%), Gaps = 5/80 (6%)

Query: 782 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 841
           HHA++  A GFC+ N + I    L       ++L +D+D+HHG+G Q+AFY    ++ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191

Query: 842 LHRYDEGN-FFPGSGAPNEV 860
            H+Y  GN FFPG+G   EV
Sbjct: 192 FHKY--GNYFFPGTGDMYEV 209


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 11/111 (9%)

Query: 45  QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI----KELLAIKQQQELL 100
           Q QQ+LLL+QQQ Q+Q+QLL  +  +  + L  Q QAQLQ+ +    +E L  +QQQ+LL
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295

Query: 101 EKEQKL--EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           +++Q+   +QQ Q   +E    E+    L   D G E+     E++Q+ QE
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ-----ELEQQRQE 341



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 30/92 (32%), Positives = 59/92 (64%), Gaps = 2/92 (2%)

Query: 33  MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLA 92
           + P +  + +++QLQ +   +Q+QQ++Q+Q    + Q+  E    Q Q QLQ+ ++E   
Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203

Query: 93  IKQQQELLEKEQKLEQQRQEQEVERHRREQQL 124
           ++QQQE L+++Q L+QQ Q Q+ +  ++++QL
Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQL 235



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%)

Query: 335 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 390
           PAV + + AS   +E    +++ + Q L Q  P P Q           PH+ L+ +P   
Sbjct: 67  PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125

Query: 391 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450
             Q L Q   L+++  Q          +H Q        + P ++  H+  + +P    +
Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166

Query: 451 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 510
              L Q        Q Q QQ L++Q+Q QQQ+   +LL +  EQL+Q    L + +E+LQ
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224

Query: 511 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 570
             Q  Q+          +      +    GQ+      ++ +   + AQ+Q+    +Q A
Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272

Query: 571 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 605
            +QQ  L     +    +Q  L     + L++ +L
Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 35/99 (35%), Positives = 63/99 (63%), Gaps = 10/99 (10%)

Query: 42  REKQLQQELLLIQQQQQIQKQ---LLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
           +++QLQQ+    QQQ+Q+Q+Q   LL+ +  +  + L +Q QAQLQ+ + E    + QQ+
Sbjct: 219 QQEQLQQQQFQ-QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQ 277

Query: 99  LLEKEQKLEQQRQEQEVERHRREQ------QLPPLRGKD 131
           LL ++Q+  QQ+Q+Q++ + ++EQ      Q PPL  ++
Sbjct: 278 LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/101 (38%), Positives = 60/101 (59%), Gaps = 19/101 (18%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
           ++ QLQQ+L L QQQ Q+Q+QLL+ +     Q+Q + L +Q Q QLQ+   +   ++ ++
Sbjct: 258 QQAQLQQQL-LEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316

Query: 98  EL----------LEKEQKLEQQRQE----QEVERHRREQQL 124
           E           L  EQ+LEQQRQE    QE+ER + ++QL
Sbjct: 317 EEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 34/112 (30%), Positives = 66/112 (58%), Gaps = 20/112 (17%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           + Q  QE  ++QQQ+Q+Q+Q+       Q + L +Q Q QL           QQQ+LL++
Sbjct: 178 QTQQAQEQQVLQQQEQLQQQV-------QEQQLLQQQQEQL-----------QQQQLLQQ 219

Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154
           +++L+QQ+ +Q+ E+ +++QQL  L  + +G+ +     + + +LQ+ LL +
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQL--LLLQQQGQLQQQLLQQQQAQLQQQLLEQ 269



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/130 (29%), Positives = 68/130 (52%), Gaps = 28/130 (21%)

Query: 43  EKQLQQELLLIQQQQQIQKQLL------------------------IAEFQKQHENLTRQ 78
           ++Q QQ+LL  QQQ+Q+Q+Q L                          E ++Q + L RQ
Sbjct: 287 QQQQQQQLLQ-QQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQ 345

Query: 79  HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138
            + + Q+  ++ L +K Q+EL + EQ+LEQ  Q+Q++E+   + +L P+    + +E  +
Sbjct: 346 QELERQQEQRQ-LQLKLQEELQQLEQQLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQL 402

Query: 139 ASTEVKQKLQ 148
             T V+ +LQ
Sbjct: 403 ELTPVQPELQ 412



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 33/106 (31%), Positives = 60/106 (56%), Gaps = 9/106 (8%)

Query: 47  QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQ 104
           QQ+L  +QQ+  Q +  Q L  E Q  H+    Q Q Q Q+ ++E   ++QQQE L+ +Q
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQ----QQQLQPQQ-VQEQQRLQQQQEQLQTQQ 181

Query: 105 KLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148
             EQQ  +Q++++++  +EQQL   + +   +++ +   E  Q+ Q
Sbjct: 182 AQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 14/121 (11%)

Query: 39  PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQ 96
           P  RE QLQQ    ++QQ + Q+Q    + Q+   +L  Q Q Q   Q+ + +L   K Q
Sbjct: 84  PGQRELQLQQ----LEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQ 139

Query: 97  ----QELLEKEQKLEQQRQ---EQEVERHRREQQLPPLRGKDRGRERAVASTE-VKQKLQ 148
               QEL  + Q + QQ+Q   +Q  E+ R +QQ   L+ +    ++ +   E ++Q++Q
Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199

Query: 149 E 149
           E
Sbjct: 200 E 200



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%)

Query: 393 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450
           Q  LQ  LL++Q  Q  Q+LL      L  Q  L  +E++    +      +   L + Q
Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306

Query: 451 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 496
             P P     +  ++              +Q +Q LE+Q++ ++Q    +L  K  E+L+
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366

Query: 497 QPGSHLEEAEEELQGDQAMQE 517
           Q    LE+ +++L+  +   E
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%)

Query: 393 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 444
           Q LLQ    +EQ++QQ+L      PL P+     +  + P   G+ +        L R +
Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346

Query: 445 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 503
            L R Q     +    QL +Q++ QQ  ++ +Q QQQ+   ++ L  +  +L   G+  +
Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398

Query: 504 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 549
           E + EL   Q  +Q +  P++G    +   A     +   G V V+E
Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           E  L++E L +QQ+ +   + L     KQ + L +Q Q   + HIK LL  +Q++   +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402

Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
           E++    EQQR+E      QE E+ RR + +  LR ++  R +A    E K+K  E    
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457

Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
                      +  S     +L    A+  SL Q            +  LPG +     +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507

Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
                P  K A    ++ R+R+     ++++SPL + K G+  T  +  + + +      
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561

Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
           +S + P   P  P  GP  S+  +   + P   P P ++ +  Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)

Query: 42  REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
           R+ +   + LL Q+Q++I++Q      + E Q++     +  + + Q  ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440

Query: 98  ELLE-------KEQKLEQQRQEQEVERHRREQ 122
           E  +       K ++LE+QRQ + ++R  +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)

Query: 40  VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           V  +++ ++E   +Q+++Q   Q  + + Q       R+   + QE+ ++ L  ++Q E 
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464

Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
           L+++ + E       QQ+Q+Q+  + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           E  L++E L +QQ+ +   + L     KQ + L +Q Q   + HIK LL  +Q++   +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402

Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
           E++    EQQR+E      QE E+ RR + +  LR ++  R +A    E K+K  E    
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457

Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
                      +  S     +L    A+  SL Q            +  LPG +     +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507

Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
                P  K A    ++ R+R+     ++++SPL + K G+  T  +  + + +      
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561

Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
           +S + P   P  P  GP  S+  +   + P   P P ++ +  Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)

Query: 42  REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
           R+ +   + LL Q+Q++I++Q      + E Q++     +  + + Q  ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440

Query: 98  ELLE-------KEQKLEQQRQEQEVERHRREQ 122
           E  +       K ++LE+QRQ + ++R  +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)

Query: 40  VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           V  +++ ++E   +Q+++Q   Q  + + Q       R+   + QE+ ++ L  ++Q E 
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464

Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
           L+++ + E       QQ+Q+Q+  + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           E  L++E L +QQ+ +   + L     KQ + L +Q Q   + HIK LL  +Q++   +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402

Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
           E++    EQQR+E      QE E+ RR + +  LR ++  R +A    E K+K  E    
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457

Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
                      +  S     +L    A+  SL Q            +  LPG +     +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507

Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
                P  K A    ++ R+R+     ++++SPL + K G+  T  +  + + +      
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561

Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
           +S + P   P  P  GP  S+  +   + P   P P ++ +  Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)

Query: 42  REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
           R+ +   + LL Q+Q++I++Q      + E Q++     +  + + Q  ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440

Query: 98  ELLE-------KEQKLEQQRQEQEVERHRREQ 122
           E  +       K ++LE+QRQ + ++R  +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)

Query: 40  VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           V  +++ ++E   +Q+++Q   Q  + + Q       R+   + QE+ ++ L  ++Q E 
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464

Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
           L+++ + E       QQ+Q+Q+  + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 91/395 (23%), Positives = 156/395 (39%), Gaps = 88/395 (22%)

Query: 15  PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74
           P  +  +S    +T L++    +    +++Q QQ+     QQQQ Q+Q    +FQ Q   
Sbjct: 138 PHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--QQFQAQQSA 195

Query: 75  LTRQHQA------------QLQEHIKEL-----LAIKQQQELLEKEQKLEQQRQEQEVER 117
           + +Q QA            Q Q+H+ +L       I+QQQ+ L++  +L+ Q+Q+Q+ ++
Sbjct: 196 MQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQ 255

Query: 118 HRREQQ-----LPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRH 172
            +++QQ      PP++     + +   S  + Q+LQ+             + ++H     
Sbjct: 256 QQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM-----------HHTQHHQPPPQ 304

Query: 173 PKLWYTAAHHTSLDQSSPPLSGTSP--SYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRL 230
           P+    A +  S     PP S T P  S    LPG          +   ++P LK   R 
Sbjct: 305 PQQPPVAQNQPS---QLPPQSQTQPLVSQAQALPG----------QMLYTQPPLKF-VRA 350

Query: 231 KQKVAERRSSPLLRRKDGNVVTSFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPT 283
              V +    P ++++   V T+   +M     +V++SS   +SS SPG    +P +   
Sbjct: 351 PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS--- 407

Query: 284 GSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNA 343
                     +PP P       Q                +S    N++ G    PS    
Sbjct: 408 ----------MPPPPQPSPQPGQP---------------SSQPNSNVSSGPAPSPSSFLP 442

Query: 344 SNSLKEKQKCETQTLRQ--GVPLPGQYGGSIPASS 376
           S S +  Q   T    Q   VP PG     +  SS
Sbjct: 443 SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 477



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 100/483 (20%), Positives = 168/483 (34%), Gaps = 114/483 (23%)

Query: 34  MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAI 93
           M VV     + QLQ + + +QQQQQ Q      +FQ+Q +   +Q Q Q           
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQ----------- 183

Query: 94  KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
            QQQ+  + +Q   QQ+ +  V++   +QQL                 + +Q+ Q+ L+ 
Sbjct: 184 -QQQQQFQAQQSAMQQQFQAVVQQ---QQQL-----------------QQQQQQQQHLIK 222

Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
                      +   + R  +L         L Q            +  L  AQ      
Sbjct: 223 LHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQQALQ-AQPPIQQP 273

Query: 214 PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGS 273
           P+++    P+  +  +L+Q    +   P                                
Sbjct: 274 PMQQPQPPPSQALPQQLQQMHHTQHHQP-------------------------------- 301

Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
            P  P   P   V +N+ S LPP    + +VSQ + L  +       LYT P L  +   
Sbjct: 302 -PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------MLYTQPPLKFVRA- 350

Query: 334 LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSHPHVTLEGKPPNSS 391
            P V  Q      ++++Q          +  PG      S+P  SS P    + + P S 
Sbjct: 351 -PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS-PSPGQQVQTPQSM 408

Query: 392 HQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISPGIRGTHKLPRHRP 445
                      +   Q    V+ G    P S      P  ++  ++        +P   P
Sbjct: 409 PPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGP 468

Query: 446 LNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
           LN   +   P S ++     Q + QQ+L+K KQ          LSK IE L++  + +++
Sbjct: 469 LNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKYIEPLRRMINKIDK 515

Query: 505 AEE 507
            E+
Sbjct: 516 NED 518



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)

Query: 436 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 490
           GT  +  H     + + P  Q  L Q+ +QQQ QQ  F ++Q+   Q QQQ    +    
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191

Query: 491 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 550
               ++Q    + + +++LQ  Q  Q+        + +          L ++  ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249

Query: 551 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 610
                +  Q Q+     Q    Q P  +P        +  P  A+     + H   ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299

Query: 611 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 649
             P     P  A ++P  L P S T     PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 48/187 (25%), Positives = 90/187 (48%), Gaps = 17/187 (9%)

Query: 23  PLDLRTDLRMMMP-VVDPVVREKQLQQELL-------LIQQQQQI--QKQLLIAEFQKQH 72
           PL +   + MM P V+ P   ++ LQQ++L       L+QQQQ +  Q+Q L   ++KQ 
Sbjct: 84  PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143

Query: 73  ENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDR 132
           E L  Q   Q Q+  +      QQQ+  +++Q+ +QQ+Q+Q+ ++ +++QQ     GK  
Sbjct: 144 EQLHLQLLQQQQQQQQ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQA 197

Query: 133 GRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPP 191
             ++     + +   Q+ +  +   +      + H +S +   L        +L   S P
Sbjct: 198 KEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLP 257

Query: 192 LSGTSPS 198
            +G SP+
Sbjct: 258 QAGLSPA 264



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)

Query: 424 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 483
           + T + I+P  +   ++ + + L+  Q   L Q   A ++ QQQ Q+F +KQ   Q+Q+H
Sbjct: 93  MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147

Query: 484 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 543
           +  L  +  +Q +Q     ++ +++ Q  Q  Q+ +             A       Q  
Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207

Query: 544 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 601
                ++ V   +  Q+Q+++  +    +Q+  L   P    AL V+  P A +    ++
Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267

Query: 602 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 652
           +  + V+  HS     +  H  +D      S+T  +      P +  H  V G S+
Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 44/199 (22%), Positives = 95/199 (47%), Gaps = 17/199 (8%)

Query: 43  EKQLQQELL---LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           EK+L+QE     L ++Q++ + QLL  E +++ + L R+ + +L++ +K     +++ E 
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-----REEVER 609

Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159
           LE+E++ EQ+ + +E E  RR+Q L     ++R R++ +   + +++ Q     +   + 
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEER-RQQQLRREQQERREQRLKREEEEERL 668

Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219
                + H   R  +           +Q+   +    P +++ L    DA+      K  
Sbjct: 669 EQRLKREHEEERREQ----ELAEEEQEQARERIKSRIPKWQWQLESEADARQS----KVY 720

Query: 220 SEPNLKVRSRLKQKVAERR 238
           S P  +   R +Q+  E+R
Sbjct: 721 SRPRKQEGQRRRQEQEEKR 739



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 40/117 (34%), Positives = 66/117 (56%), Gaps = 10/117 (8%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           RE+QL++E  L ++QQ  ++Q L  E Q + E   R+ Q   +E  +E    K +QE  E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444

Query: 102 KEQKLEQQ------RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           +  K EQ+      ++E+E ERH   RR+QQL   + ++R RER +   E +++ Q+
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER-RERWLKLEEEERREQQ 500



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 27/83 (32%), Positives = 54/83 (65%), Gaps = 1/83 (1%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKELLAIKQQQELL 100
           RE+QL++E  L ++QQ  ++Q L  E Q ++ + L R+ Q + ++ ++    ++++QE  
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432

Query: 101 EKEQKLEQQRQEQEVERHRREQQ 123
             EQK EQ+R+EQ ++R + E++
Sbjct: 433 RHEQKHEQERREQRLKREQEERR 455



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 37/129 (28%), Positives = 67/129 (51%), Gaps = 18/129 (13%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           RE+QL++E  L ++QQ  ++Q      QK  +    Q   + QE  ++ L  +++ E  E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468

Query: 102 KEQKLEQQRQEQEVER----------------HRREQQLPPLRGKDRGRERAVASTEVKQ 145
           +E++ +Q +++QE ER                 RREQQL   R ++  RE+ +   E ++
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL--RREQEERREQRLKRQEEEE 526

Query: 146 KLQEFLLSK 154
           +LQ+ L S+
Sbjct: 527 RLQQRLRSE 535



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 29/111 (26%), Positives = 66/111 (59%), Gaps = 5/111 (4%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK--ELLAIKQQQELL 100
           E++LQ+E    Q++ Q +++ L  + ++Q     RQ + Q Q+ ++  + L  KQ++E  
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQL-RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
           E++++  +Q++ +E +  RREQQL   R ++  RE+ +   + +++ ++ L
Sbjct: 316 EQQEERREQQERREQQEERREQQL--RREQEERREQQLRREQEEERREQQL 364



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 37/211 (17%), Positives = 96/211 (45%), Gaps = 21/211 (9%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQ--KQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           RE+QL++E    +++QQ++++  +   Q  ++ + L R+ Q + ++ ++    ++++Q+L
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419

Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159
             ++Q   +Q +E+  ++H +E++   L+ +   R   +   E  ++ ++    +   +D
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479

Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219
                +          W         +Q            +  L   Q+ + +  L++  
Sbjct: 480 QEEERRER--------WLKLEEEERREQQE--------RREQQLRREQEERREQRLKRQE 523

Query: 220 SEPNLKVRSRLKQKV---AERRSSPLLRRKD 247
            E  L+ R R +Q++    E R   LL+R++
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREE 554



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 32/131 (24%), Positives = 72/131 (54%), Gaps = 7/131 (5%)

Query: 19  EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78
           EP    +L+ +   +  +    +R ++ ++E    QQQQ+++++  +   Q++     ++
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEE----QQQQRLRREQQLRRKQEEERREQQE 319

Query: 79  HQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRERA 137
            + + QE  ++    ++QQ   E+E++ EQQ R+EQE ER  REQQL   + ++R  ++ 
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEER--REQQLRREQEEERREQQL 377

Query: 138 VASTEVKQKLQ 148
               +++++ Q
Sbjct: 378 RREQQLRREQQ 388



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 32/113 (28%), Positives = 65/113 (57%), Gaps = 8/113 (7%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           R+++LQ+E    +Q +++++Q L  E Q++ +   R  + Q     +E    +QQ+E  E
Sbjct: 267 RQRELQEEE---EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323

Query: 102 KEQKLEQQ--RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           ++++ EQQ  R+EQ++ R    RREQQL   + ++R  ++     E +++ Q+
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/139 (25%), Positives = 71/139 (51%), Gaps = 33/139 (23%)

Query: 44   KQLQQELLLIQQQQQIQKQLLIAEFQKQHE--NLTRQHQAQLQEHIKELLAIKQ------ 95
            ++ ++E   +Q++QQ+++Q L  +F+++ +    T Q Q + QE  +++L  +Q      
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760

Query: 96   QQEL--------LEKEQKLEQQRQEQEVE---------------RHRREQQLPPLR--GK 130
            +Q+L          +E++L Q+R+EQ++                + R EQQL P +  GK
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820

Query: 131  DRGRERAVASTEVKQKLQE 149
             R  E  +   E +Q+L++
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQ 1839



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/123 (21%), Positives = 69/123 (56%), Gaps = 10/123 (8%)

Query: 42  REKQL--QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
           RE++L  Q+E   +QQ+ + ++QL   + +++ + L R+ + +L++  +E    ++Q+E 
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574

Query: 100 LEKEQKLEQQRQEQEVERHRRE--------QQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
            ++  K E++R++Q ++R + E        +++  L  ++R  +R       +++ Q+ L
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634

Query: 152 LSK 154
            S+
Sbjct: 635 KSE 637



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 26/85 (30%), Positives = 56/85 (65%), Gaps = 6/85 (7%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98
            R ++L+++    ++ QQ ++QLL  E +K+  + L RQ+  + +LQ+  ++LL  +Q++ 
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191

Query: 99   LLEKEQKLEQQRQEQEVERHRREQQ 123
              E+E+   Q R+E+E++R +R+Q+
Sbjct: 1192 RQERER---QYREEEELQRQKRKQR 1213



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 27/98 (27%), Positives = 62/98 (63%), Gaps = 10/98 (10%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           RE+QL++E    +++QQ++++    E +++ + L R+ Q + ++ ++    ++++Q+L  
Sbjct: 347 REQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLRREQQLRREQQLRREQQL-R 402

Query: 102 KEQKLEQQRQEQEVERH---RREQQLPPLRGKDRGRER 136
           +EQ+L   R+EQ++ R    RREQQL   + ++R  ++
Sbjct: 403 REQQL---RREQQLRREQQLRREQQLRREQEEERHEQK 437



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/109 (25%), Positives = 67/109 (61%), Gaps = 15/109 (13%)

Query: 54  QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ---------QELL--EK 102
           +QQ++ ++QL   + +++ + L RQ +   +E +++ L  +QQ         ++LL  E+
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEE---EERLQQRLRSEQQLRREQEERREQLLKREE 554

Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
           E++LEQ+R+EQ ++R + E++   L+ ++  R++ +   E +++L++ L
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRL-KREQEERLEQRL 602



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 25/100 (25%), Positives = 59/100 (59%), Gaps = 5/100 (5%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE----LLAIKQQQ 97
           RE++ +Q+ L  +Q+++++++L   E ++  +   R+ + + +E  +E    LL  ++Q+
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 98  ELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRER 136
           E  +++ + EQQ R+EQ ++R   E++L     ++   ER
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/120 (26%), Positives = 69/120 (57%), Gaps = 13/120 (10%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
            R+ + +++LL  +++QQ+ +Q    +F ++ + L RQ + +     +EL + + +++ LE
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE-QELRSQEPERKFLE 1519

Query: 102  KEQKLEQQR-------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154
            +EQ+L +Q+       +EQ++ R  R QQ    R +DR R +     +++Q+ +E  LS+
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQ----RRQDRDR-KFREEEQLRQEREEQQLSR 1574



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 11/114 (9%)

Query: 38   DPVVREKQLQQ---ELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94
            D   RE++L+    E   ++++QQ+ +Q    +F ++ + L RQ + Q +         +
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR--------Q 1551

Query: 95   QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148
             +     +E++L Q+R+EQ++ R  R+++      K R +E+     E +Q+L+
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 25/91 (27%), Positives = 54/91 (59%), Gaps = 6/91 (6%)

Query: 47   QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106
            ++E L +++Q+Q  +Q    +++ + E    Q +++ +E  +EL   ++Q+   E+E+KL
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREE--QELWQEEEQKRRQERERKL 1880

Query: 107  EQQ---RQEQEVERHRREQQLPPLRGKDRGR 134
             ++   RQ++E +RHR+  ++    GK  GR
Sbjct: 1881 REEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 34/125 (27%), Positives = 64/125 (51%), Gaps = 12/125 (9%)

Query: 45  QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI-KELLAIKQQQELLEKE 103
           Q  QE    Q+Q++ QK     E +++    T   +  LQE + KE   +++++E L++E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 104 QKLEQQRQEQEVERHRREQQLPP----------LRGKDRGRERAVASTEVKQKLQEFLLS 153
           ++ +++RQEQE  ++R E+QL             + + + RER     +  Q+ +E LL 
Sbjct: 917 EREKRRRQEQE-RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975

Query: 154 KSATK 158
           +   K
Sbjct: 976 EEPEK 980



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 36/119 (30%), Positives = 69/119 (57%), Gaps = 12/119 (10%)

Query: 42   REKQLQQELLLIQQ--QQQIQKQLLIAEFQKQHENLTRQHQAQ--LQEHIKELLAIKQQQ 97
            R+++ ++E  L+Q+  +QQ+++Q    +F+++ + L RQ + +  LQE  ++L   + ++
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE-QQLRRQELER 1723

Query: 98   ELLEKEQKLEQQRQEQ--EVERHRR---EQQLPPLRGKD--RGRERAVASTEVKQKLQE 149
            +  E+EQ  ++  QEQ    ER+R+   E+QL P R +   R +ER     E +Q  QE
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 27/109 (24%), Positives = 60/109 (55%), Gaps = 2/109 (1%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-QAQLQEHIKELLAIKQQQELL 100
           RE  L++E   +Q+++  Q+Q  + E ++Q   L RQ  + + QE  ++   ++++Q+L 
Sbjct: 249 RETVLRKEEEKLQEEEP-QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307

Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
            K+++  +++QE+  E+  R +Q    R +   RE+     +  ++ QE
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 34/125 (27%), Positives = 70/125 (56%), Gaps = 19/125 (15%)

Query: 43  EKQLQQELLLI------QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK-- 94
           E+QL++  LL       +++QQ +++     FQ++ E   R+ +  L++  ++L   +  
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 95  QQQELLEKEQKL----------EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVK 144
           +Q+EL E+E++L          E+Q +EQ+ +R RREQQL   + ++R RE+     E +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQ 325

Query: 145 QKLQE 149
           ++ ++
Sbjct: 326 ERREQ 330



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 23/83 (27%), Positives = 52/83 (62%), Gaps = 9/83 (10%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           RE+Q ++E    QQ+++ ++QL   + +++ + L R+ + + +E       ++++QE   
Sbjct: 322 REQQERRE----QQEERREQQLRREQEERREQQLRREQEEERREQ-----QLRREQEEER 372

Query: 102 KEQKLEQQRQEQEVERHRREQQL 124
           +EQ+L +++Q +  ++ RREQQL
Sbjct: 373 REQQLRREQQLRREQQLRREQQL 395



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 33/135 (24%), Positives = 66/135 (48%), Gaps = 25/135 (18%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------QLQEHI 87
           + ++ ++EL  +++++Q+Q++    + Q++ + L    +               QL+E  
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882

Query: 88  KE----LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEV 143
           K     L A    QE L KEQ+L Q+ +E+E++R  RE++      + + +ER     E 
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQE-EEEELQREEREKR------RRQEQERQYREEEQ 935

Query: 144 KQKLQEFLLSKSATK 158
            Q+ +E LL +   K
Sbjct: 936 LQQEEEQLLREEREK 950



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 29/123 (23%), Positives = 66/123 (53%), Gaps = 9/123 (7%)

Query: 38   DPVVREKQLQQELL-LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH--IKELLAIK 94
            D  +R++Q QQ+L  L+ +QQ+  ++     +Q++  +   + Q + +E    K      
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314

Query: 95   QQQELLEKEQKLEQQRQEQEVERHRREQQL------PPLRGKDRGRERAVASTEVKQKLQ 148
            Q+++ L +E++ E++R+++   + R E+QL       PLR ++R R+        +++ +
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374

Query: 149  EFL 151
            +FL
Sbjct: 1375 KFL 1377



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 29/120 (24%), Positives = 63/120 (52%), Gaps = 16/120 (13%)

Query: 42   REKQLQQEL--LLIQQQQQIQKQLLIAEFQKQHENLTRQH----------QAQLQEHIKE 89
            RE+QL+Q+      +++QQ+ +Q    +F+++ + + RQ           Q + + H K 
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK- 1462

Query: 90   LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
                +++++LL++ ++ +  RQE++ +    EQQL       + RE+ + S E ++K  E
Sbjct: 1463 ---FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 23/81 (28%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           R++QL++E    ++Q++ +++  +AE ++Q E   R  Q   Q   +EL   +Q+QE  E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW--RQRQEWQE 182

Query: 102 KEQKLEQQRQEQEVERHRREQ 122
           +E++  ++ Q Q  + H  E+
Sbjct: 183 REERRAEEEQLQSCKGHETEE 203



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 32/112 (28%), Positives = 60/112 (53%), Gaps = 8/112 (7%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ--EHIKELLAIKQQQEL 99
           RE+QL+ E    ++QQ+ Q+ L   E ++Q     R+ + +LQ  E  ++L   ++ Q+L
Sbjct: 794 RERQLRAE----ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849

Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
            E+E  L++ ++ +  +  RR+Q+      ++R R R   +   K  LQE L
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR--HTLYAKPALQEQL 899



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 30/129 (23%), Positives = 69/129 (53%), Gaps = 20/129 (15%)

Query: 39   PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
            P ++E+  +++ LL ++++++Q++        + E   RQ Q   +   +E   ++Q++E
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQRE--------EREKRRRQEQ---ERQYREEEQLQQEEE 941

Query: 99   LLEKEQKLEQQRQEQEVERHR------REQQL---PPLRGKDRGRERAVASTEVKQKLQE 149
             L +E++ +++RQE+E +  +      +E+QL    P + + + RE+     E  Q+ +E
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 150  FLLSKSATK 158
             LL +   K
Sbjct: 1002 QLLREEREK 1010



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 33/125 (26%), Positives = 66/125 (52%), Gaps = 14/125 (11%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
            R ++L+++    ++ QQ ++QLL  E +K+     R+ Q + +E +++     ++++LL 
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQ-ERERQCREEEELQQ-----EEEQLLR 1125

Query: 102  KE------QKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLS 153
            +E      Q+LE+Q +E+E  +   EQ L   P + + +  ER     E  Q+ +E LL 
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 154  KSATK 158
            +   K
Sbjct: 1186 EEQEK 1190



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 26/88 (29%), Positives = 54/88 (61%), Gaps = 5/88 (5%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           RE+QL+++    +++QQ +++      ++Q E   +Q + + +E  ++ L  +Q++E  E
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361

Query: 102 KEQKLEQQ--RQEQEVERH---RREQQL 124
           ++ + EQ+  R+EQ++ R    RREQQL
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQL 389



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 22/107 (20%), Positives = 60/107 (56%), Gaps = 2/107 (1%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           +++ +Q+L   Q++++ ++ L + E +++ +   R+ Q + ++  +    +K+Q+E    
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528

Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           +Q+L  ++Q +  +  RREQ L   R +++  E+      +K++ +E
Sbjct: 529 QQRLRSEQQLRREQEERREQLLK--REEEKRLEQERREQRLKREQEE 573



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 31/123 (25%), Positives = 66/123 (53%), Gaps = 15/123 (12%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK-------ELLAIK 94
            R+ Q +++LL  +++++ ++Q    +F+++ + L  + +  L+   +       EL   +
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371

Query: 95   QQQELLEKEQKLEQQ-------RQEQEVERHRREQQLPPLRG-KDRGRERAVASTEVKQK 146
            Q ++ LE+EQ+L +Q       ++EQ++    REQQL   R  K R  E+ ++  E  +K
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431

Query: 147  LQE 149
             +E
Sbjct: 1432 FRE 1434



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 29/115 (25%), Positives = 61/115 (53%), Gaps = 4/115 (3%)

Query: 38   DPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94
            D   RE++L   +Q    ++++Q++++Q    +F K+ + L  Q + Q     ++    +
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 95   QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
            ++Q+L  +E+  + + +EQ+V R  RE++      + R +ER     E +Q LQE
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR-QERHRKFREEEQLLQE 1472



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 26/108 (24%), Positives = 60/108 (55%), Gaps = 2/108 (1%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           +E++ QQE    QQ ++ Q++    + +++ E   R+ Q + ++  +      ++++ L 
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384

Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           +EQ+L +++Q +  ++ RREQQL   R +   RE+ +   +  ++ QE
Sbjct: 385 REQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQE 430



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 32/107 (29%), Positives = 59/107 (55%), Gaps = 7/107 (6%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100
            RE+Q ++E    ++ QQ ++QLL  E +K+  + L RQ++ + +   +E   ++++ E  
Sbjct: 1106 RERQCREE----EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK- 1160

Query: 101  EKEQKLEQQRQEQEVERHRREQQLPPLRGKDR-GRERAVASTEVKQK 146
             + Q+LE+Q +E+E  +   EQ L   + K R  RER     E  Q+
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207



 Score = 37.7 bits (86), Expect = 0.047
 Identities = 23/107 (21%), Positives = 58/107 (54%), Gaps = 1/107 (0%)

Query: 44   KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ-QELLEK 102
            ++ +QE   ++ +QQ+++Q    + +++ +   R+ +  LQE  ++ L  +++ ++ LE+
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648

Query: 103  EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
            E +L +Q +EQ++   R  +     +    G E+ +   E  +K +E
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695



 Score = 37.7 bits (86), Expect = 0.047
 Identities = 28/116 (24%), Positives = 58/116 (50%), Gaps = 8/116 (6%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE--------LLAI 93
            R+ +  ++LL  +++QQ+ +Q    +F ++   L RQ + Q   H ++        LL  
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678

Query: 94   KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
             ++Q+L  +E+  + + +EQ++ R  RE++      + R +E      E +Q  QE
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734



 Score = 37.4 bits (85), Expect = 0.062
 Identities = 31/121 (25%), Positives = 61/121 (50%), Gaps = 12/121 (9%)

Query: 43  EKQLQQELLLIQQQQQIQK-QLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
           E++ +QEL   +Q+Q  ++ +  I ++Q Q E+     Q+++    ++    +++QE  E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLR-----------GKDRGRERAVASTEVKQKLQEF 150
           K ++ E + Q QE ER  R+QQ    R             +RGR+R  A   ++++ +  
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 151 L 151
           L
Sbjct: 798 L 798



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 23/91 (25%), Positives = 55/91 (60%), Gaps = 5/91 (5%)

Query: 47   QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQ-AQLQEHIKELLAIKQQQELLEKEQK 105
            +++ L  Q+++Q  +Q    +F+++ + L+RQ +  + +E  +++   +++++ LE+EQ+
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454

Query: 106  LEQQR----QEQEVERHRREQQLPPLRGKDR 132
            L Q+R    +E+E     RE+Q    + +DR
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDR 1485



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 15/125 (12%)

Query: 43   EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
            E+QL+QE    +++QQ++ Q    +++ + E L  + Q Q     ++     ++Q   ++
Sbjct: 1800 EEQLRQE----REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855

Query: 103  EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPT 162
            + + E+Q   QE E+ RR++           RER +    ++++ +E    +   +    
Sbjct: 1856 KSRREEQELWQEEEQKRRQE-----------RERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904

Query: 163  NGKNH 167
             GK H
Sbjct: 1905 EGKGH 1909



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 27/102 (26%), Positives = 59/102 (57%), Gaps = 8/102 (7%)

Query: 27  RTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH 86
           R + R+    V+ + +E++ +Q L   + +++ ++QLL +E  +Q E   +Q + + QE 
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE--EQEERRQQQLRREQQER 654

Query: 87  IKELLAIKQQQELLEKEQKLE--QQRQEQEV----ERHRREQ 122
            ++ L  ++++E LE+  K E  ++R+EQE+    +   RE+
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 32/122 (26%), Positives = 65/122 (53%), Gaps = 8/122 (6%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98
            R ++ +++     + QQ ++QLL  E +K+  +   RQ+  + +LQ+  ++LL  +++  
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071

Query: 99   LLEKEQKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLSKSA 156
               + Q+LE+Q +++E  +   EQ L   P + + + RER     E  Q+ +E LL +  
Sbjct: 1072 ---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128

Query: 157  TK 158
             K
Sbjct: 1129 EK 1130



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 22/77 (28%), Positives = 47/77 (61%), Gaps = 1/77 (1%)

Query: 47  QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106
           ++ LL  ++Q++ Q++    + Q + E   R+ Q + QE  +EL   ++Q E  E+ ++ 
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKR-QEQERELAEGEEQSEKQERLEQR 164

Query: 107 EQQRQEQEVERHRREQQ 123
           ++QR+++E+ R R+E Q
Sbjct: 165 DRQRRDEELWRQRQEWQ 181



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 32/131 (24%), Positives = 70/131 (53%), Gaps = 13/131 (9%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL---QEHIKELLAIKQQQE 98
           RE+Q ++E  L ++Q++ ++Q L  + +++      + + QL   QE  +E L  +++++
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556

Query: 99  LLEKEQ-----KLEQQRQEQEV---ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150
            LE+E+     K EQ+ +  ++   E  RR+Q+L   R ++   E+ +   EV++  QE 
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEE 614

Query: 151 LLSKSATKDTP 161
              +   ++ P
Sbjct: 615 RREQRLKREEP 625



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 35/123 (28%), Positives = 69/123 (56%), Gaps = 14/123 (11%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQA--QLQEHIKELLAIKQQQE 98
            REK+ ++E    ++ QQ ++QLL  E +K+  +   RQ++   +LQ+  ++LL  ++++ 
Sbjct: 986  REKKYREE----EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041

Query: 99   LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLLSKS 155
             L++ ++  Q R+E+E+++   E+QL     + R R   ER     E  Q+ +E LL + 
Sbjct: 1042 RLQERER--QYREEEELQQ--EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 156  ATK 158
              K
Sbjct: 1098 PEK 1100



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 24/87 (27%), Positives = 49/87 (56%), Gaps = 15/87 (17%)

Query: 43   EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
            E+QL+QE    +++QQ+ +Q    +F+ + + + RQ Q       ++ +  +QQ    E 
Sbjct: 1560 EEQLRQE----REEQQLSRQERDRKFRLEEQKVRRQEQE------RKFMEDEQQLRRQEG 1609

Query: 103  EQKLEQQ-----RQEQEVERHRREQQL 124
            +Q+L Q+     R+++++ + R EQQL
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQL 1636



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 28/127 (22%), Positives = 66/127 (51%), Gaps = 12/127 (9%)

Query: 40   VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQ 97
            ++ E+QL+ E    +++QQ+++Q    +F+++ +    + + QL  QE  ++    +Q +
Sbjct: 1749 ILEEEQLRPE----REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804

Query: 98   ELLEKEQKLEQQR------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
            +  E++Q   QQR      +E++++   +EQ+L   R +    E   A+ E  ++ ++ L
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864

Query: 152  LSKSATK 158
              +   K
Sbjct: 1865 WQEEEQK 1871



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 36/126 (28%), Positives = 64/126 (50%), Gaps = 20/126 (15%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
            RE+Q ++E    ++ QQ ++QLL        E  TR+ Q +L+   ++   ++Q++E L 
Sbjct: 1046 RERQYREE----EELQQEEEQLL------GEERETRRRQ-ELERQYRKEEELQQEEEQLL 1094

Query: 102  KEQKLEQQRQE------QEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLL 152
            +E+  +++RQE      +E E  + E+QL     + R R   ER     E  Q+ +E LL
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 153  SKSATK 158
             +   K
Sbjct: 1155 REEPEK 1160



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 25/111 (22%), Positives = 61/111 (54%), Gaps = 19/111 (17%)

Query: 44   KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQELLE 101
            ++ ++E   ++++QQ++++    +F+++ + L  + + QL  QE  ++ L  +QQ    E
Sbjct: 1440 RRQERERKFLEEEQQLRQERH-RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498

Query: 102  KEQKLEQQ------------RQEQEVERHRRE----QQLPPLRGKDRGRER 136
            +++K  +Q             +EQ++ R +R+    Q+   LR ++RG++R
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 38/128 (29%), Positives = 61/128 (47%), Gaps = 23/128 (17%)

Query: 42  REKQLQQELLLIQQQQQIQKQ--LLIAEFQKQHENLTRQHQ------------AQLQE-- 85
           R+K+ +QE  L + ++Q +KQ  L   + Q++ E L RQ Q             QLQ   
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197

Query: 86  -HIKELLAIKQQ---QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAST 141
            H  E    ++Q   +ELLE  +K  +++Q+Q  ER  R  Q      +   R+R     
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ---EEEEKEWRKRETVLR 254

Query: 142 EVKQKLQE 149
           + ++KLQE
Sbjct: 255 KEEEKLQE 262



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 11/103 (10%)

Query: 43  EKQLQQ----ELLLIQQQQQIQKQLLI-----AEFQKQHENLTRQHQAQLQEHIKELLAI 93
           E+QLQ     E      ++Q++++ L+        +KQ +   RQ +   +E  KE    
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR-- 247

Query: 94  KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 136
           K++  L ++E+KL+++  +++ E    E+QL  L  ++  RER
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 30/113 (26%), Positives = 61/113 (53%), Gaps = 10/113 (8%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHE----NLTRQHQAQLQEHIKELLAIKQQQ 97
           R   L++E    + +Q+ +KQ L  + +++       L  + + + QE  ++ L  +Q++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513

Query: 98  ELLEKEQKLEQQRQEQEV-ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
               +EQ+L++Q +E+ + +R R EQQL   R ++  RE+ +   E K+  QE
Sbjct: 514 ---RREQRLKRQEEEERLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQE 561



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 26/132 (19%), Positives = 69/132 (52%), Gaps = 7/132 (5%)

Query: 19   EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78
            +P     LR + +++    + + RE++ ++     ++Q + ++QL   E Q   E   ++
Sbjct: 892  KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951

Query: 79   HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138
             + + +   ++   ++Q++E L  E+  +++RQE+E +++R E++L       +  E+ +
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE-KKYREEEEL------QQEEEQLL 1004

Query: 139  ASTEVKQKLQEF 150
                 K++ QE+
Sbjct: 1005 REEREKRRRQEW 1016



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 27/109 (24%), Positives = 59/109 (54%), Gaps = 7/109 (6%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100
            +E+Q ++E    +Q QQ ++QLL  E +K+  +   RQ++   +   KE   + ++ E  
Sbjct: 926  QERQYREE----EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981

Query: 101  EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
             ++++ ++ R+E+E+++   E+QL     + R R+        K +LQ+
Sbjct: 982  RRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWERQYRKKDELQQ 1028



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 29/130 (22%), Positives = 63/130 (48%), Gaps = 11/130 (8%)

Query: 29   DLRMMMPVVDPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 85
            +LR   P    +  E+QL   Q++   +Q++QQ+++Q    + ++  +   R+ +   QE
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566

Query: 86   HIKELLAIKQQQELLE-KEQKLEQQRQE-------QEVERHRREQQLPPLRGKDRGRERA 137
              ++ L+ +++      +EQK+ +Q QE       Q++ R   +QQL   R +    +  
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626

Query: 138  VASTEVKQKL 147
            +     +Q+L
Sbjct: 1627 LLQEREEQQL 1636



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 8/94 (8%)

Query: 52  LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQ 111
           L+Q ++Q + Q       +Q E    Q + Q ++        +Q++EL E E++ E+Q +
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ--------EQERELAEGEEQSEKQER 160

Query: 112 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145
            ++ +R RR+++L   R + + RE   A  E  Q
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 31/206 (15%)

Query: 42   REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
            RE+Q +++  L    QQ ++QLL  E +K+     RQ + +     +EL   +Q++E L 
Sbjct: 956  RERQYRKDKKL----QQKEEQLLGEEPEKRR----RQEREKKYREEEEL---QQEEEQLL 1004

Query: 102  KEQKLEQQRQEQEVERHRR-------EQQLPPLRGKDR--GRERAVASTEVKQKLQEFLL 152
            +E++ +++RQE E +  ++       EQ L   R K R   RER     E  Q+ +E LL
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064

Query: 153  SKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDD 212
                       G+     R  +L         L Q    L    P  +      +  +++
Sbjct: 1065 -----------GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113

Query: 213  FPLRKTASEPNLKVRSRLKQKVAERR 238
              L++   +   + R + +++  ER+
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQ 1139



 Score = 33.5 bits (75), Expect = 0.89
 Identities = 27/108 (25%), Positives = 60/108 (55%), Gaps = 7/108 (6%)

Query: 43   EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
            E Q ++E LL ++ ++ ++Q L  +++++ E   +Q + QL    +E    +++++  E+
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKRRQERERQYREE 1202

Query: 103  EQKLEQQRQEQEVERHRREQQLPPLRGK-DRGRERAVASTEVKQKLQE 149
            E+   Q+R+    +R+R E Q   L+ + +  +E AV   +V  K +E
Sbjct: 1203 EELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 38/124 (30%), Positives = 62/124 (50%), Gaps = 23/124 (18%)

Query: 42  REKQLQ-QELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL-------QEHIKELLAI 93
           RE +LQ QE     +QQQ ++Q     +Q Q E  + + + +L       ++  ++L A 
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801

Query: 94  KQQQ-------ELLEKEQKLEQQRQ-EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145
           ++QQ       E  EKEQ+  Q+R+ E+E++    E+QL       + RERA    E + 
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL-------QRRERAQQLQEEED 854

Query: 146 KLQE 149
            LQE
Sbjct: 855 GLQE 858



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 34/144 (23%), Positives = 71/144 (49%), Gaps = 21/144 (14%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELL---------- 91
           RE++L++E    + +Q+++++    E +++ + L  + Q Q +E IK  +          
Sbjct: 655 REQRLKREEEEERLEQRLKRE---HEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711

Query: 92  AIKQQQELLEKEQKLEQQRQEQEV-E-RHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
           A  +Q ++  + +K E QR+ QE  E R RRE +L     + +  ERA    + +++ ++
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL-----QWQEEERAHRQQQEEEQRRD 766

Query: 150 FLLSKSATKDTPTNGKNHSVSRHP 173
           F     A ++    G+    +R P
Sbjct: 767 FTWQWQA-EEKSERGRQRLSARPP 789



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 28/146 (19%), Positives = 65/146 (44%), Gaps = 34/146 (23%)

Query: 43   EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------------- 81
            E++LQ++    + + + Q+  L  +++ + EN  R ++                      
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261

Query: 82   QLQEHIKELLAIKQQQEL-------------LEKEQKLEQQRQEQEVERHRREQQLPPLR 128
            Q Q+ ++ LL  +Q+++                +E++LE++ Q++   R R+ Q+   L 
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321

Query: 129  GKDRGRERAVASTEVKQKLQEFLLSK 154
             ++R  +R    T+ K + +E LL +
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQE 1347


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 68/273 (24%), Positives = 115/273 (42%), Gaps = 43/273 (15%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
           E  L++E L +QQ+ +   + L     KQ + L +Q Q   + HIK LL  +Q++   +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402

Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
           E++    EQQR+E      QE E+ RR + +  LR ++  R +A    E K+K  E    
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457

Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
                      +  S     +L    A+  SL Q            +  LPG +     +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507

Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
                P  K A    ++ R+R+     ++++SPL + K G+  T  +  + + +      
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561

Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTP 298
           +S + P   P  P  GP  S+ +  T  L   P
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 53/271 (19%), Positives = 109/271 (40%), Gaps = 30/271 (11%)

Query: 42  REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
           R+ +   + LL Q+Q++I++Q      + E Q++     +  + + Q  ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440

Query: 98  ELLE-------KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150
           E  +       K ++LE+QRQ + ++R + +Q+   L+   + +++     +  QK Q+ 
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQR-QLQQEHAYLKSLQQQQQQ-----QQLQKQQQQ 494

Query: 151 LLSKSATKDTPTNGKNHSVSRHP--------KLWYTAAHHTSLDQSSPPLSGTSPSYKYT 202
            L     K     G+  + +  P        +       ++ L +S P  +G  P     
Sbjct: 495 QLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554

Query: 203 LPGAQDAKDDFPLRKTASEPNLKVRSRLK-QKVAERRSSPLLRRKDGNV--VTSFKKRMF 259
            PG        P  +   EP       L+ Q      + P     D  +   T+      
Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARG 614

Query: 260 EVTESSVSSSSPGSGPSSPNNGPTGSVTENE 290
            V   +   +S G GPS   N P     +NE
Sbjct: 615 AVIRQNSDPTSEGPGPSP--NPPAWVRPDNE 643


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 18/178 (10%)

Query: 39   PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
            P+   +QLQQ+  L QQQQQ+Q+Q      Q+Q +   +  Q QLQ+  ++    +QQQ+
Sbjct: 3893 PMGSLQQLQQQQQL-QQQQQLQQQQ-----QQQLQQQQQLQQQQLQQQQQQQQLQQQQQQ 3946

Query: 99   LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK-----------L 147
             L+++Q+  QQ+Q+Q+ ++ +++QQ   +   ++ R       + +Q+           L
Sbjct: 3947 QLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPL 4006

Query: 148  QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 205
            Q F    +        GK  + +  P +   A    S  Q  P   GT+P    T PG
Sbjct: 4007 QHFSSPGALGPTLLLTGKEQN-TVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 139/660 (21%), Positives = 236/660 (35%), Gaps = 137/660 (20%)

Query: 43   EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
            E   ++  L+ +QQ +IQKQL  + + QK+H NL  +++             KQQQ+   
Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN------------KQQQQ--- 3602

Query: 102  KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
             +Q+ +QQ+Q+          Q P L  K  G+       +  Q            + TP
Sbjct: 3603 -QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLRLTP 3659

Query: 162  TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASE 221
                       P L    A       S    S   PS  +  PG    +   P  +   E
Sbjct: 3660 GGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRLLQE 3718

Query: 222  PNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG--- 274
              L++   R +L QK+ +++     ++   G V    +++     +++ +      G   
Sbjct: 3719 RQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP 3778

Query: 275  PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRILIHE 313
            PSS            P  GP G +   + +VL         P  PH + +++Q R+L   
Sbjct: 3779 PSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL--- 3835

Query: 314  DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIP 373
                     +SP L     GL  +  +L  +   +++Q+ + Q    G+    Q   S+ 
Sbjct: 3836 ---------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ---SLM 3881

Query: 374  ASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPG 433
            + S  P   L  +P  S  Q   Q  L ++Q  QQ+           Q  L  ++++   
Sbjct: 3882 SHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL--- 3926

Query: 434  IRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIE 493
                            Q   L Q    Q + QQQ QQ  ++Q+Q QQQ    +   +  +
Sbjct: 3927 ----------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQ 3970

Query: 494  QLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVKVKE 549
            Q +Q G  L ++   L   Q  Q+  A   G   +      S   +  TL   G  +   
Sbjct: 3971 QQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTV 4029

Query: 550  EPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTHT-- 582
            +P  S                          E  +++   SG+    + QP  +P  +  
Sbjct: 4030 DPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSL 4089

Query: 583  ------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGSAT 633
                  R    +Q  ++ +   G   H  +    SS A+SV   L  P++    QPGS T
Sbjct: 4090 QLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMT 4149


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 104/548 (18%), Positives = 217/548 (39%), Gaps = 68/548 (12%)

Query: 43   EKQLQQELLLIQQQQQIQKQL--LIAEFQKQHENLTRQHQAQLQ-------EHIKELLAI 93
            +K L  +++ IQ++ +   Q+  +   ++ Q+E L  Q    ++       +H ++ +++
Sbjct: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473

Query: 94   KQQQELLE-------KEQKLEQQRQ-------EQEVERHRREQQLPPLRGK-DRGRERAV 138
            ++ QEL E       K + LE Q +       E+E E    ++Q   L+ +  R R+   
Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ 1533

Query: 139  ASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPS 198
              T  +++L++ +  K          +   V+   K+ + A     L + +  L   +  
Sbjct: 1534 DRTTQEEQLRQQITEKEEKT------RKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-- 1585

Query: 199  YKYTLPGAQDA-KDDFPLRKTASEPNLKVR-SRLKQKVAERRSSPLLRRKDGNVVTSFKK 256
                  GA D  KD+  +R TA +   + R SRL++++ E +   L +R +    ++   
Sbjct: 1586 ------GALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVP 1639

Query: 257  RMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSM 316
                      + +S   G +S ++ PT ++        P    A  M   +         
Sbjct: 1640 EQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKST----PRA 1695

Query: 317  NLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASS 376
            ++  + T  ++ N T    A    +  +  ++ ++  +++   + VP+ G   GS+ ++S
Sbjct: 1696 SIRPMVTPATVTNPTTTPTAT---VMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTS 1752

Query: 377  SHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRG 436
              P+V            ++ Q +L  +Q  Q    V      HPQ   A +E  S  +  
Sbjct: 1753 --PNV----------QPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800

Query: 437  THKLPRHRPLNRT----QSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 492
                P  RP   T      +  P S+L +   +++    +E   Q      +   L K +
Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDT-VEMPLPKKL 1859

Query: 493  EQLKQPGSHLE-EAEEELQGD---QAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVK 548
            + +   G+  E  AEE   G+   Q   +D   S G          ++D+     ++++ 
Sbjct: 1860 KSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQID 1919

Query: 549  EEPVDSDE 556
              P+ SD+
Sbjct: 1920 LGPLQSDQ 1927



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 25/113 (22%), Positives = 57/113 (50%), Gaps = 6/113 (5%)

Query: 41   VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKEL----LAIKQQ 96
            V   + +Q + L++++ Q  +  L AE +K    +T +  AQ +E +K+     + ++  
Sbjct: 1219 VESLRYRQRVELLERELQELQDSLNAEREKVQ--VTAKTMAQHEELMKKTETMNVVMETN 1276

Query: 97   QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
            + L E++++LEQ  Q+ + +  + E  + PL+  +          + ++KL E
Sbjct: 1277 KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLE 1329


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 29/246 (11%)

Query: 53  IQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQ 111
           +++QQ +Q+Q L     ++ E   RQ  A+ Q+ I++    K+Q+  LE++Q+ E++ R+
Sbjct: 370 LRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ---KEQRRRLEEQQRREREARR 421

Query: 112 EQEVERHRREQ-------QLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNG 164
           +QE E+ RREQ       +L   R ++  R RA       ++ QE++  +   +      
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481

Query: 165 KNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ----DAKDDFPLR 216
               + +   +    +   H     Q  PP    S PS+    P A     D   + P+R
Sbjct: 482 LQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVR 541

Query: 217 KTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGP 275
            T+  P L  R    Q   ++ S    R    N  +S + R ++E  E  V     GS  
Sbjct: 542 TTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERVEKLVPRPGSGSSS 597

Query: 276 SSPNNG 281
            S N+G
Sbjct: 598 GSSNSG 603


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 35/131 (26%), Positives = 74/131 (56%), Gaps = 4/131 (3%)

Query: 20  PISPLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTR 77
           P +   +   + MM P V+ P   ++ LQQ++L  QQ Q + Q+Q  +   Q+Q +   +
Sbjct: 106 PHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYK 165

Query: 78  QHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 137
           + Q QL  H++ L   +QQQ+  +++Q+ +QQ+Q+Q+ ++ +++QQ    + +  G++  
Sbjct: 166 KQQEQL--HLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAK 223

Query: 138 VASTEVKQKLQ 148
               + +Q+ Q
Sbjct: 224 EQQQQQQQQQQ 234



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 28/283 (9%)

Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAG--GVPLHPQSPLA--------TKERISPGIRG 436
           P +S  Q  LQ LL      + KL + G      HP +  A        T + I+P  + 
Sbjct: 76  PKSSDKQRPLQELL-----PETKLCICGHSSGDGHPHNTFAVPVSVAMMTPQVITP--QQ 128

Query: 437 THKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 496
             ++ + + L+  Q   L Q   A ++ QQQ Q+F +KQ   Q+Q+H+  L  +  +Q +
Sbjct: 129 MQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLHLQLLQQQQQQQQQ 185

Query: 497 QPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDE 556
           Q     ++ +++ Q  Q  Q+ +             A       Q       ++ V   +
Sbjct: 186 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQ 245

Query: 557 DAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLEK-HRLVSRTHSSP 613
             Q+Q+++  +    +Q+  L   P    AL V+  P A +    +++  + V+  HS  
Sbjct: 246 LLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSME 305

Query: 614 AASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 652
              +  H  +D      S+T  +      P +  H  V G S+
Sbjct: 306 DNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 347


>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
          Length = 347

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 51/211 (24%), Positives = 92/211 (43%), Gaps = 35/211 (16%)

Query: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706
           G    HP  AG+   + + L+E  LL+    ++ R+AS E++ +VH+  +   L +    
Sbjct: 30  GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89

Query: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
               ++ P I L +    +K    L                      R   G  I +A K
Sbjct: 90  ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126

Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822
           +A   ++ G+A+    G HH       GFC +  + +  K+L +++  IS+  I+DLD H
Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183

Query: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPG 853
            GNG ++ F  D  +  + ++     + +PG
Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPG 211


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,008,166
Number of Sequences: 37866
Number of extensions: 1884689
Number of successful extensions: 19616
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 679
Number of HSP's that attempted gapping in prelim test: 9866
Number of HSP's gapped (non-prelim): 5511
length of query: 879
length of database: 18,247,518
effective HSP length: 111
effective length of query: 768
effective length of database: 14,044,392
effective search space: 10786093056
effective search space used: 10786093056
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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