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Search of human proteins with 16933557
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16933557 dachsous 1 precursor [Homo sapiens]
(3298 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16933557 dachsous 1 precursor [Homo sapiens] 6543 0.0
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 1397 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 1152 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 922 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 922 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 880 0.0
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 807 0.0
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 802 0.0
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 431 e-120
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 425 e-118
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 414 e-115
gi|216548395 dachsous 2 isoform 3 [Homo sapiens] 398 e-110
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 348 4e-95
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 348 4e-95
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 342 5e-93
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 342 5e-93
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 330 2e-89
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 330 2e-89
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 330 2e-89
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 330 2e-89
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 327 1e-88
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 327 1e-88
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 327 1e-88
gi|94538350 protocadherin 17 precursor [Homo sapiens] 322 5e-87
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur... 317 2e-85
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur... 317 2e-85
gi|7706113 protocadherin 12 precursor [Homo sapiens] 316 2e-85
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs... 315 4e-85
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs... 315 4e-85
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur... 314 8e-85
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 6543 bits (16975), Expect = 0.0
Identities = 3298/3298 (100%), Positives = 3298/3298 (100%)
Query: 1 MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTL 60
MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTL
Sbjct: 1 MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTL 60
Query: 61 IGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAV 120
IGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAV
Sbjct: 61 IGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAV 120
Query: 121 TPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY 180
TPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY
Sbjct: 121 TPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY 180
Query: 181 ALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQAL 240
ALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQAL
Sbjct: 181 ALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQAL 240
Query: 241 LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSE 300
LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSE
Sbjct: 241 LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSE 300
Query: 301 GDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360
GDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP
Sbjct: 301 GDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360
Query: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV 420
SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV
Sbjct: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV 420
Query: 421 IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPE 480
IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPE
Sbjct: 421 IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPE 480
Query: 481 PLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL 540
PLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL
Sbjct: 481 PLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL 540
Query: 541 EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV 600
EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV
Sbjct: 541 EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV 600
Query: 601 TATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAV 660
TATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAV
Sbjct: 601 TATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAV 660
Query: 661 DGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRL 720
DGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRL
Sbjct: 661 DGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRL 720
Query: 721 SYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI 780
SYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI
Sbjct: 721 SYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI 780
Query: 781 VPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLD 840
VPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLD
Sbjct: 781 VPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLD 840
Query: 841 AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDT 900
AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDT
Sbjct: 841 AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDT 900
Query: 901 VLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSG 960
VLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSG
Sbjct: 901 VLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSG 960
Query: 961 GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL 1020
GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL
Sbjct: 961 GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL 1020
Query: 1021 QVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080
QVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA
Sbjct: 1021 QVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080
Query: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRL 1140
ELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRL
Sbjct: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRL 1140
Query: 1141 TYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVA 1200
TYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVA
Sbjct: 1141 TYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVA 1200
Query: 1201 VLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPG 1260
VLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPG
Sbjct: 1201 VLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPG 1260
Query: 1261 SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP 1320
SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP
Sbjct: 1261 SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP 1320
Query: 1321 PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFA 1380
PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFA
Sbjct: 1321 PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFA 1380
Query: 1381 LDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP 1440
LDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP
Sbjct: 1381 LDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP 1440
Query: 1441 LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG
Sbjct: 1441 LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
Query: 1501 LDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPP 1560
LDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPP
Sbjct: 1501 LDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPP 1560
Query: 1561 GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV
Sbjct: 1561 GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
Query: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA
Sbjct: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
Query: 1681 NGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
NGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA
Sbjct: 1681 NGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
Query: 1741 VEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVL 1800
VEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVL
Sbjct: 1741 VEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVL 1800
Query: 1801 DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1860
DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY
Sbjct: 1801 DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1860
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE 1920
SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE
Sbjct: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE 1920
Query: 1921 QCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPT 1980
QCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPT
Sbjct: 1921 QCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPT 1980
Query: 1981 LALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVA 2040
LALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVA
Sbjct: 1981 LALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVA 2040
Query: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNG 2100
TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNG
Sbjct: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNG 2100
Query: 2101 PITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLT 2160
PITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLT
Sbjct: 2101 PITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLT 2160
Query: 2161 LQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLF 2220
LQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLF
Sbjct: 2161 LQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLF 2220
Query: 2221 HVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP 2280
HVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP
Sbjct: 2221 HVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP 2280
Query: 2281 WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE 2340
WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE
Sbjct: 2281 WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE 2340
Query: 2341 QCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA 2400
QCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA
Sbjct: 2341 QCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA 2400
Query: 2401 TDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
TDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP
Sbjct: 2401 TDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY
Sbjct: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
Query: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP
Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
Query: 2581 PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT 2640
PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT
Sbjct: 2581 PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT 2640
Query: 2641 VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVN 2700
VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVN
Sbjct: 2641 VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVN 2700
Query: 2701 DHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFAL 2760
DHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFAL
Sbjct: 2701 DHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFAL 2760
Query: 2761 NSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHF 2820
NSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHF
Sbjct: 2761 NSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHF 2820
Query: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSG 2880
QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSG
Sbjct: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSG 2880
Query: 2881 TATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGA 2940
TATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGA
Sbjct: 2881 TATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGA 2940
Query: 2941 VAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSE 3000
VAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSE
Sbjct: 2941 VAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSE 3000
Query: 3001 HLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSL 3060
HLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSL
Sbjct: 3001 HLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSL 3060
Query: 3061 AARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFL 3120
AARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFL
Sbjct: 3061 AARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFL 3120
Query: 3121 GGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVF 3180
GGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVF
Sbjct: 3121 GGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVF 3180
Query: 3181 TEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPIS 3240
TEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPIS
Sbjct: 3181 TEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPIS 3240
Query: 3241 HEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI 3298
HEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI
Sbjct: 3241 HEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI 3298
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 1397 bits (3617), Expect = 0.0
Identities = 973/2917 (33%), Positives = 1458/2917 (49%), Gaps = 210/2917 (7%)
Query: 483 PEVALPGSFVVR-------------VTARDPDQGTNGQVTYSLAPGAHTHW----FSIDP 525
PE L G+ V R VTA D D G G + YSL G ++ F IDP
Sbjct: 54 PETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 113
Query: 526 TSGIITTAASLDYELEPQP-QLIVVATDGGLPP----------LASSATVSVALQDVNDN 574
G I + +D E +P L+V A DG L++ A V V L+DVNDN
Sbjct: 114 HDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDN 173
Query: 575 EPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAH 634
P F + Y S+ + TQPGT + V ATD DSG +G ++Y L G SS F ID+
Sbjct: 174 HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS---LFTIDST 230
Query: 635 SGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMV-YVKVFLSDENDNPPQFYPREYAAS 693
+G + S+ +F+ L+ + ++ F E D E +
Sbjct: 231 TGLYSPEVEI-----LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRG 285
Query: 694 ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRAN 753
+ + L+ D + G + +A + L G++ + PL+ +
Sbjct: 286 WFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKIL-----GEGIIYLTLPLSHLES 340
Query: 754 SVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQ 813
+ + L + A+DGGGL A +A V I I T P FE+ +Y F V EDV + +G V+
Sbjct: 341 TTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
Query: 814 AHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873
A P P+ +S GD G FS+ G ++T +PLD E PV+ L V+A G P
Sbjct: 401 AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ-PVVVLTVQAQLGSAP 459
Query: 874 AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933
A + V + + DVNDN PAF D + + T PGT +Y RA D DSG N + +++
Sbjct: 460 ACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI 519
Query: 934 LAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGT 993
+ G F +D G + L LG L L A D G P+ + L VV++
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK--- 576
Query: 994 RGLAPR--FNSPTYRVDLPSGTTAGTQVLQVQAQAPDG-----GPITYHLAAEGASSPFG 1046
R +P F Y+V++ + TQ+LQ QA P G P+ Y L S+ FG
Sbjct: 577 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH-PLGPQRAASPLRYSLEPSVDSAMFG 635
Query: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
+ P +GW+++R D E+ + Y +V A L Q + TV V + ++N++SP
Sbjct: 636 IRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFL 693
Query: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
D FL V E+ P +G++ A D DSG NG+L Y L D K F+++P TG T+
Sbjct: 694 HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKFFKMNPNTGPAGTI 750
Query: 1167 QT--------------------------------------------LDREQQSSYQLLVQ 1182
LDRE + +++ V
Sbjct: 751 YVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVL 810
Query: 1183 VQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAK 1242
V D GSPPR+ T V+V+V D+NDN P F Q G L ++V + P LVTT+ AK
Sbjct: 811 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQC--LPGKELHVKVLEGQPVNMLVTTVFAK 868
Query: 1243 DPDEGENGTILYTLTGP-GSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPR 1301
DPDEG N + Y+++ S+ F + ++GE+ T L RP Y +++ A DQG PP
Sbjct: 869 DPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPL 928
Query: 1302 SASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAG 1361
+ +QV+P L++ +++ +P E L+P ++ + + +
Sbjct: 929 QGQAVVNIQVIP---LSKGRAIMSQNIRHLIIP--------ENLKPTKIMSLIKSSDHLQ 977
Query: 1362 V---GALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAG-A 1417
G L +++V D +G F +D+++G L+L++ LD+E + + + +
Sbjct: 978 QHYNGKLHFSIVAD-DKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLS 1036
Query: 1418 RLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLL 1477
+ + + V+D+N+H+P+F + + +++ EN G +Y F A D DG NS ++Y +
Sbjct: 1037 STVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIE 1096
Query: 1478 RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVT 1537
P + G L LDRE+ P ++L V A+D+ N + RR ++A++ +
Sbjct: 1097 SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVIL 1156
Query: 1538 DENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHS 1596
D ND+ P F S + ED G H+ A DPD G +V+Y + SG + F L
Sbjct: 1157 DVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDE 1216
Query: 1597 STGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV 1656
S+G L+ PLD E + +H+LTV+A D G+P S++Q LTV+V DVNDEAP F+Q Y
Sbjct: 1217 SSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA 1276
Query: 1657 LLRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREE 1713
++EN PG + + A D D G N ++ + G S E F ++ DTG + T LDRE
Sbjct: 1277 SVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREI 1336
Query: 1714 QEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLR 1773
QE L V +D G P + T+ VEDENDHAP F + +EV E Q+P+ + +
Sbjct: 1337 QEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL 1396
Query: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
ASD D G N ++Y I+DG+ F ++ SGE T R LDRE F L I D G P
Sbjct: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDP 1456
Query: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYY 1893
S+ + L V VLDANDH+P+FP Y V ED GT++L L A D D G NG Y+
Sbjct: 1457 PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516
Query: 1894 LGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
L +GAF ++P SG L+T+ LDRE +TFS A D + G STTV + + V DV
Sbjct: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
Query: 1954 NDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
ND+ P +P + L P+ T + +RA+D D G N ++++ A T ++
Sbjct: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVI----VRADDLDLGPNGTVVFSFAETQSM-FSI 1631
Query: 2014 DSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASS 2073
D YTGEI+ ++P + L + TD G PAR+ TG++++ ++GE + F
Sbjct: 1632 DKYTGEIQFQQNP-SSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVK-ISFSHHLY 1689
Query: 2074 EATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLD 2133
+ + EN GT IV+ +A + YSI SGNE G S+ +G +TV+ + LD
Sbjct: 1690 KGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLD 1749
Query: 2134 FEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQV 2193
FEV ++L++ AES G A+ + + +QD NDN+P F + Y A + ES+ ++QV
Sbjct: 1750 FEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQV 1809
Query: 2194 EADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRG 2253
A DLD G G I YS+ + F +D +G ITT AILD E+ + L++ ATD+G
Sbjct: 1810 FATDLDSGLNGLIEYSILSGNQEEA-FQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
Query: 2254 SPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD-SGPVLWYV 2312
P L + + V V D NDN P + ++ED+L G + V+ +DVD + ++
Sbjct: 1869 MPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
Query: 2313 LSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDN 2372
S P F++ + G V L LDFE+ Y+L + D H L V V DVNDN
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDN 1988
Query: 2373 APAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLF 2432
P FSQ YQV + E P G ++L++SATD +S N +ISY + S + FS+DP NGT+F
Sbjct: 1989 PPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPKNGTIF 2046
Query: 2433 TIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVT 2492
TI + L D ++EA D G P A V + ++D N++AP FT+ Y ++++
Sbjct: 2047 TISPVLLL--DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLS 2104
Query: 2493 EDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALG 2552
ED GSTL+T D D +R + V+YSIISGN F +E + + + +G
Sbjct: 2105 EDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY----KQVG 2160
Query: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
LVLL LD E+ + L + A+D G PP SS +++ VLDVNDNPP F+ SY V
Sbjct: 2161 YLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVK 2220
Query: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
E TP+G+ + V A+D D G H + + + SG+ G F L+E++G L L LD E +
Sbjct: 2221 ESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK 2280
Query: 2673 HQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAID 2732
L VQA+D HF+ A V + V D NDH P F + S V EN P + + +++A+D
Sbjct: 2281 FTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD 2340
Query: 2733 GDAGAFGRLRYSLLEAGPGPEG----REAFALNSSTGELRARVPFDYEHTESFRLLVGAA 2788
DAG +G L YS++ G + F ++ TG++ A+ DYE+ + L V A
Sbjct: 2341 FDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK 2400
Query: 2789 DAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLV 2848
D G+ +AS+ V V + G DE++P+F + F +PE + +G V+A+D D G DG++
Sbjct: 2401 DKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVI 2460
Query: 2849 LYSLATSSPYFGINQTTGALYL-----RVDSRAPGSGTATSGGGGRTRREAPRELRLEVI 2903
LYSL TSSP+F +N+T G +YL + S+ T L +++I
Sbjct: 2461 LYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDT----------------LEMKII 2504
Query: 2904 ARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVV-----VLALAALVL 2958
A P S+ A+ V V+++ ++ G L V A + S+ +VV ++ + L++
Sbjct: 2505 AHSPKSDSKFASCTVFVNVSFSSEGTP-----LAVFASSFSISLVVSFLVFLILICILIV 2559
Query: 2959 GLVRARSRKA-----EAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHLYHQTLPSYGGP 3013
++R + + E + + D+ + +E + P +
Sbjct: 2560 MILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSL 2619
Query: 3014 GAGGPYPRGGSLDPSHSSGRGS--AEAAEDDEIRMINEFPRVASVASSLA---ARGPDSG 3068
+ S+SSG S E AED EI+ INE P S+L+ +R PDSG
Sbjct: 2620 ISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSG 2679
Query: 3069 IQQDADGLSDTSCE---------PPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAF 3119
I +D+D LS S E A T+ +G + G T + P T
Sbjct: 2680 IPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQG----EGCSTTCAQNNVLPQTVQKR 2735
Query: 3120 LGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASV 3179
+ + F + + AL+ + + + +Y+W+YLLSW P+FQPLASV
Sbjct: 2736 EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV 2795
Query: 3180 FTEIARLKDEARPCPPAPR-----IDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPAS 3234
F +IA+LKDE P P+ + PPPLITAVA PG K+VPP+ A PP
Sbjct: 2796 FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPR--MPAVNLGQVPPKH 2853
Query: 3235 HRSPIS-HEGSLSSAAMSPSFSPSLSPLAARSPVVSP 3270
RSPI H GSL M+P+FSPSLS L + P +SP
Sbjct: 2854 PRSPIPYHLGSLPE-GMTPNFSPSLSLLTMQPPALSP 2889
Score = 621 bits (1601), Expect = e-177
Identities = 623/2180 (28%), Positives = 940/2180 (43%), Gaps = 195/2180 (8%)
Query: 53 EEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR 112
E+ P + IG + A P ++ P+ Y IS+ + +G +I G +RT + LD E +
Sbjct: 388 EDVPEDSPIGTVKAREPLNSSEPIFYRISSGD---LGGKFSIHPRLGTIRTRKPLDHETQ 444
Query: 113 DRYRFTAVT-----PDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPA 167
T P ++ EV + V D+ND+ PAF + +++ + T GT L A
Sbjct: 445 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
Query: 168 RDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEA 227
D D+GR G Y+++ G F ++ G L + G L + L L A
Sbjct: 505 EDRDSGRNGLIRYSIASPQPG-VFAIDRALG-------VLFLNGSLGAGEQRELTLTLRA 556
Query: 228 YDGGSPPRRAQALLDVTLLDINDHAPA--FNQSRYHAVVSESLAPGSPVLQVFASDADAG 285
D G P+ A +L V +++ +H+P+ F Y VSESL+P + +LQ A
Sbjct: 557 EDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GP 614
Query: 286 VNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA---RDGGAHPE 342
A + S F I +TG + L R D+E + + V A DG +
Sbjct: 615 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG--FLQ 672
Query: 343 LGSAFVTVHVRDANDNQPSM--TVIFLSADGSPQVSEAAPPGQLVARISVSDPD------ 394
S V V V D NDN P+ V+FL + SP P ++ +I+ D D
Sbjct: 673 NVSTTVIVRVWDENDNSPTFLHDVLFLKVEESP------VPQGVIGKITAIDMDSGKNGQ 726
Query: 395 -------DGDFAHVNVS---------LEGGEGHFALSTQDSVI-----------YLVCVA 427
DG F +N + + +G A S D L C
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 428 RR--------LDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRP 479
LDRE R + + V TD GSPP A A + VTD+NDN P F + L
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 480 EPLPEVALPGS----FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAAS 535
E L L G V V A+DPD+G N +VTYS++ + F ID +G I T
Sbjct: 847 E-LHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTI 905
Query: 536 LDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGT 595
L Y+ P ++ V+ATD G+PPL A V++ + ++ + + +PE +P
Sbjct: 906 LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
Query: 596 CFLQVTATDADSGPF-GLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFD 654
+ ++D + G L +S+ + F ID+ +GD+ ++ LD + S +
Sbjct: 966 IMSLIKSSDHLQQHYNGKLHFSI---VADDKDGHFEIDSSTGDLFLSKELDYET-TSHYL 1021
Query: 655 FTVTAVDGG---GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHD 711
F V D L S V++ + + D+ND+ P F S+ P GT V A D
Sbjct: 1022 FRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD 1081
Query: 712 PDQGS--HGRLSYHILA---GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG 766
D GS + R+ Y+I + G +P F + G L L R + V L + A D
Sbjct: 1082 -DDGSFLNSRIQYYIESHNPGTNP--FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQA 1138
Query: 767 GLQAEPSAR---VDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP-PGRLA 822
+ R I I+ P F V EDV G+ V + AH+P GR
Sbjct: 1139 VNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHITAHDPDEGRNG 1197
Query: 823 PVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRV 882
VT S+ G+ F LD SGLL T PLD E+ + + G P + + V
Sbjct: 1198 KVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTV 1257
Query: 883 LLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-GAF 941
+ DVND +P F + N PG + + ALD DSGVNS++ F ++ G F
Sbjct: 1258 TVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELF 1317
Query: 942 TVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFN 1001
++ TG V L L + RDGG P +S + V+D AP F
Sbjct: 1318 EINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDH--APEFI 1375
Query: 1002 SPTYRVDLPSGTTAGT--QVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAA 1059
+Y +++ VL A + + YH+ F + SG L A
Sbjct: 1376 VSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRA 1435
Query: 1060 LDREAQELYILKVMAVSGSKAELGQQTGTATV--RVSILNQNEHSPRLSEDPTFLAVAEN 1117
LDRE + L ++ ++LG ++ + +V +L+ N+HSP +V E+
Sbjct: 1436 LDREQISNFTLVILC-----SDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED 1490
Query: 1118 QPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSY 1177
GT V + A D+D G NG+ Y L E S AF I P +G + T TLDRE +S +
Sbjct: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFL--TDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548
Query: 1178 QLLVQVQDGG-SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLV 1236
+D RSTT + V V D+NDN P Q + + P
Sbjct: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQ------NPFDVFLSPESPTNQTT 1602
Query: 1237 TTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296
++A D D G NGT++++ S +FS+ ++GE+ P + L L DQ
Sbjct: 1603 VIVRADDLDLGPNGTVVFSFAETQS-MFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQ 1660
Query: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA 1356
G P R+ + L++ + E + + E G+ + +V A
Sbjct: 1661 GIPARTTTGLLVIHM------------EGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
Query: 1357 PEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARP--LDFEAGPPWRALTVRAEGPG 1413
P + ++ Y++ G + +G +L + SG+L + P LDFE + L V AE G
Sbjct: 1709 FAPDSIQDSMKYSIFSG-NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQ-LIVLAESSG 1766
Query: 1414 GAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVR 1473
+V V +QDEN+++P F + ++ E+ A + A+D D G N +
Sbjct: 1767 HRA--YCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS-GLNGLIE 1823
Query: 1474 YRLL--RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVS 1531
Y +L QE A ++DA +G ++ LD E T + L+V+ATD+ R +
Sbjct: 1824 YSILSGNQE---EAFQIDALSGVITTKAILDYELTSSYSLIVQATDK---GMPRLSNTTV 1877
Query: 1532 ARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH 1591
+V VTD NDNAP F V + ED PG HV D DL A S+ S
Sbjct: 1878 IKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTK 1937
Query: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
F + +TG + +V+ LD E+ E+ L + SD A L V V DVND P F Q
Sbjct: 1938 FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLDVNDNPPVFSQ 1994
Query: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV-SSESFSLDPDTGVLTTLR-AL 1709
Y V + E+ P G S+LTL AT D+ +N ++Y + SS+ FS+DP G + T+ L
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKEFSIDPKNGTIFTISPVL 2052
Query: 1710 DREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQT 1768
+ V A D G+P V + +ED N++AP F +L + E T
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 1769 LTMLRASDPD-VGANGQLQYRILDGDPSGAFVLDL----------ASGEFGTMRPLDREV 1817
L D D N ++Y I+ G+ F ++ G + LDRE
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
Query: 1818 EPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQL 1877
+ +L I A D G P LS+T ++++ VLD ND+ P F +Y V E P G+ + +
Sbjct: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
Query: 1878 QAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAA 1936
A+D D G++ + Y + +G G F LE ++G L LD E+ +T +V A D A
Sbjct: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AE 2291
Query: 1937 AGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGAN 1996
S V V ++V D NDHAP F S +P P ST + ++ A D DAG
Sbjct: 2292 KKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPISST----ICSINALDFDAGPY 2346
Query: 1997 ASILYRLAGTPPPGTT-----------VDSYTGEIRVARSPVALGPRDRVLFIVATDLGR 2045
+ Y + P T +D TG+I + L + A D G
Sbjct: 2347 GELTYSIVS--PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG- 2403
Query: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITY 2104
+A+ V+ V ++G E P F + T+ E I A A G +G I Y
Sbjct: 2404 -DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
Query: 2105 SILSGNEKGTFSIQPSTGAI 2124
S+ G FS+ + G I
Sbjct: 2463 SL--GTSSPFFSVNKTNGNI 2480
Score = 615 bits (1587), Expect = e-175
Identities = 679/2533 (26%), Positives = 1066/2533 (42%), Gaps = 267/2533 (10%)
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGP--FSIDAHTGLLQLERPLDFEQ-RRVHELVV 332
+V ASDAD+G+ G + Y + + P F ID H G + + + +D E+ ++L+V
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 333 QARDGG----AHPEL------GSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPG 382
+A+DG H L AFV V + D NDN P +F + +S+ PG
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP----VFNPSTYVTSISDETQPG 193
Query: 383 QLVARISVSDPDDGDFAHV-------NVS----LEGGEGHFALSTQ-------------- 417
+ + +D D G + V NVS ++ G ++ +
Sbjct: 194 TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVM 253
Query: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
+S+ + + R + ERD S +R + LH V D A + D +
Sbjct: 254 NSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAA 313
Query: 478 RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLD 537
+ G ++ +T P S + +T S
Sbjct: 314 ARYVANLAKILGEGIIYLTL---------------------------PLSHLESTTLS-- 344
Query: 538 YELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYN----ASLPEGTQP 593
L+V A DGG +A V++ + +F+R Y +PE +
Sbjct: 345 --------LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI 396
Query: 594 GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSF 653
GT + ++ + + S LG F I G + T + LD + P
Sbjct: 397 GTVKAREPLNSSEPIFYRISSGDLGG--------KFSIHPRLGTIRTRKPLDHETQPVVV 448
Query: 654 DFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD 713
+ S V + + D NDN P F IS +PPGTA+ RA D D
Sbjct: 449 LTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 508
Query: 714 QGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS 773
G +G + Y I A P +F +D G+L + L + L + AED G+ + +
Sbjct: 509 SGRNGLIRYSI-ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAED-QGVHPQAA 566
Query: 774 ARVDISIVPGTPTPP--IFEQLQYVFSVPEDVAPGTSVGIVQAH--NPPGRLAPVTLSLS 829
V ++ P FE L Y V E ++P T + QAH P +P+ SL
Sbjct: 567 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 626
Query: 830 GGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVR----VLLD 885
+F + +G + R D E R + +P + V V +
Sbjct: 627 PSVDSAMFGIRPYTGWIYLRRQFDYE---STQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
Query: 886 DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDP 945
D NDNSP F + + + P I + A+D DSG N ++ + LL+ G F ++P
Sbjct: 684 DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS-DGKFFKMNP 742
Query: 946 TTGHVRLMRPLGPSGGPA------------------------------------------ 963
TG + + + G A
Sbjct: 743 NTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHR 802
Query: 964 --HELELEARDGGSPPRTSHFRLRVVVQDVG-TRGLAPR-FNSPTYRVDLPSGTTAGTQV 1019
HE+ + D GSPPR + + V V D+ R P+ V + G V
Sbjct: 803 GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
Query: 1020 LQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVS 1076
V A+ PD G +TY +++E +S F ++ +G + L + + Y + V+A
Sbjct: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
Query: 1077 GSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR-DSG 1135
L G A V + ++ ++ +S++ L + EN P + + ++D
Sbjct: 923 QGVPPL---QGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQH 979
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQD-GGSPPRSTT 1194
NG+L +S+ +D F I TG++ + LD E S Y V D + S+T
Sbjct: 980 YNGKLHFSIVADDKDGH-FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSST 1038
Query: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE--NGTI 1252
+ + V D ND+SP+F + I V + VP GTLV AKD D+G N I
Sbjct: 1039 VFLSIDVEDQNDHSPSFQDEL------IVISVEENVPIGTLVYVFNAKD-DDGSFLNSRI 1091
Query: 1253 LYTLT--GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQ 1310
Y + PG+ F +HP G L+T + L R P +LT++A DQ L+ L
Sbjct: 1092 QYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTA 1151
Query: 1311 VLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYT 1368
+ + + P P A V +TV GSL+ + A P+ G +TY+
Sbjct: 1152 QIVILDVNDHNPTFIS-FPNAHVKEDVTV--------GSLVHHITAHDPDEGRNGKVTYS 1202
Query: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPG-GAGARLLRVQVQVQ 1427
++ G + TF LD +SG L PLD+E LTV A G A + + V V
Sbjct: 1203 ILSG-NENMTFMLDESSGLLTTTCPLDYEM-KTQHILTVLALDDGTPALSSSQTLTVTVL 1260
Query: 1428 DENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALR 1487
D N+ AP F + ++ EN PG + A D D G NS +++ ++
Sbjct: 1261 DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDS-GVNSKLQFEIM-PGASFELFE 1318
Query: 1488 LDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF- 1546
+++ TG + LDRE L V D ++ + V DEND+AP F
Sbjct: 1319 INSDTGEVVTTTILDREIQEVFTLRVLVRD---GGFPSLSSTTTILCTVEDENDHAPEFI 1375
Query: 1547 ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVR 1605
S + + E+Q P V+A D D G V Y + G D F ++ +G LS R
Sbjct: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
Query: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
LDREQ + L ++ SD G PPRS+ L V V D ND +P+F Y +RE+ G
Sbjct: 1435 ALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVG 1494
Query: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
T +L L A D D G NGQ Y +S +F++DP +G L T LDRE + + + A
Sbjct: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
Query: 1724 QD---RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEV-PEGQDPQTLTMLRASDPDV 1779
+D +GS + T V ++V V D ND+ P + + PE QT ++RA D D+
Sbjct: 1555 RDCSIQGS--RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL 1612
Query: 1780 GANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATL 1839
G NG + + + F +D +GE + E P + L+++ D G PA + T
Sbjct: 1613 GPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTG 1669
Query: 1840 LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTA 1899
LL + ++ D +F Y V E+ AGT ++ ++A PD+ +
Sbjct: 1670 LLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNED 1728
Query: 1900 GAFLLEPSSGEL--RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHA 1957
G L SG+L + LD E V + A + V + ++D ND++
Sbjct: 1729 GVLSLCSKSGQLTVKEPKFLDFE----VRNEVQLIVLAESSGHRAYCKVAVLIQDENDNS 1784
Query: 1958 PTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSY 2016
P F S + + + + A D D+G N I Y L+G +D+
Sbjct: 1785 PCFEQSIYQASVSES----QLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDAL 1840
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEAT 2076
+G I L + ATD G P S T VI V + + P F S
Sbjct: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF-LPSEAVE 1899
Query: 2077 IRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGT-FSIQPSTGAITVRSAEGLDFE 2135
I E++ PG IV+ +VH N +S + GT F+I +TG + + + LDFE
Sbjct: 1900 ITEDSLPGV-IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVL--VKTLDFE 1956
Query: 2136 VSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEA 2195
L++Q + L + + D NDN P F + Y +PES P+ +L + A
Sbjct: 1957 EMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Query: 2196 DDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMATDRGS 2254
DL+ S ISY + +S F +DP GTI T + +L + + T+ ++ A+D G+
Sbjct: 2017 TDLE--SNENISYRILSSSKE---FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
Query: 2255 PALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVD---SGPVLW 2310
P L + + + D N+ P + + L +SEDAL+GS + + D D +
Sbjct: 2072 PDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVE 2131
Query: 2311 YVLSPSGPQDPFSVG----------RYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHE 2357
Y + Q+ F V + G + L LD E ++L +LA D P
Sbjct: 2132 YSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS 2191
Query: 2358 GRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS 2417
A +++ V DVNDN P FS Y + E TP GS I VSA DRD+G++ I Y++ S
Sbjct: 2192 STAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
Query: 2418 PAD--GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQ 2475
+ F ++ N G L+ I L ++ + ++A D + A V V + D
Sbjct: 2252 GNEKGHFYLEENTGVLYLI---KPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDD 2307
Query: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG---NWGRVFQ 2532
NDHAP F S + V E+LP ST+ ++ A D D + + YSI+S G +
Sbjct: 2308 NDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG-PYGELTYSIVSPCFLTHGMSYD 2366
Query: 2533 LEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTV 2592
+ L + G + + LD+E+ +Y LTV A D+G S VV V +
Sbjct: 2367 HDLFLIDP---------LTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEG 2417
Query: 2593 LDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFEL 2652
+D + P+FT+ Y T+PE + VEASDAD G G++ +++ + P F +
Sbjct: 2418 ID--EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP--FFSV 2473
Query: 2653 DESSGTLRLAHAL 2665
++++G + L AL
Sbjct: 2474 NKTNGNIYLIRAL 2486
Score = 606 bits (1562), Expect = e-172
Identities = 657/2488 (26%), Positives = 1040/2488 (41%), Gaps = 259/2488 (10%)
Query: 167 ARDADAGRLGTQGYALSGDG-----AGETFRLETRPGPDGTPVPELVVTGELDRE-NRSH 220
A DAD+G G Y+L DG A + FR++ G ++ V+ ++DRE + +
Sbjct: 81 ASDADSGLYGFIEYSLY-DGFLSYEAPQAFRIDPHDG-------QICVSQDIDRERDPAT 132
Query: 221 YMLQLEAYDGGSPPRR----------AQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270
Y L +EA DG AQA + V L D+ND+ P FN S Y +S+ P
Sbjct: 133 YDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQP 192
Query: 271 GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330
G+ ++ V A+D D+G+ G V YE+ F+ID+ TGL E
Sbjct: 193 GTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGLYSPEVE----------- 239
Query: 331 VVQARDGGAHPELGSAF-----VTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLV 385
++ A + A E+ ++ + H + ++ + F ++ G + +
Sbjct: 240 ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYL 299
Query: 386 ARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
+ DG+ A V+ + A + +IYL L E +L V+A
Sbjct: 300 KVQDEAASADGEAAARYVA------NLAKILGEGIIYLTLPLSHL---ESTTLSLMVSAQ 350
Query: 446 DSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYR---PEPLPEVALPGSFVVRVTARDPDQ 502
D G A +H+ F+R Y E +PE + G+ V AR+P
Sbjct: 351 DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAREP-L 405
Query: 503 GTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSA 562
++ + Y ++ G FSI P G I T LD+E +P L V A G P SS
Sbjct: 406 NSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS-APACSST 464
Query: 563 TVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLG 622
V++ + DVNDN P F RT + + T PGT A D DSG GL+ YS +
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS----IA 520
Query: 623 SSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG-GLKSMVYVKVFLSDENDN 681
S F ID G + +L + T+ A D G ++ + V + ++ ++
Sbjct: 521 SPQPGVFAIDRALGVLFLNGSLGAGE-QRELTLTLRAEDQGVHPQAALLVLTVVIEKREH 579
Query: 682 PPQ--FYPREYAASISAQSPPGTAVLRLRAHD-PDQGSHGRLSYHILAGNSPPLFTLDEQ 738
P F Y +S P T +L+ +AH Q + L Y + +F +
Sbjct: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 639
Query: 739 SGLLTVAWPLARRANSVVQLEIGA---EDGGGLQAEPSARVDISIVPGTPTPPIFEQLQY 795
+G + + + + A ED G S V + + P F
Sbjct: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPED--GFLQNVSTTVIVRVWDENDNSPTFLHDVL 697
Query: 796 VFSVPEDVAPGTSVGIVQA---------------------------HNPPGRLAPVT--- 825
V E P +G + A P G + +T
Sbjct: 698 FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWAD 757
Query: 826 --LSLSGGDPRGLFSLDAV-------------SGLLQTLRPLDRELLGPVLELEVRAGSG 870
+ SG D FS D + G L LDRE G + G
Sbjct: 758 GAAAFSGTD--FAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRG 815
Query: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTP----IYTLRALDPDSGVN 926
PP A V V + D+NDN P FP L G P + T+ A DPD G N
Sbjct: 816 SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875
Query: 927 SRVTFTLLA-GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLR 985
+ VT+++ + F +D G +R L P++ + + A D G PP +
Sbjct: 876 AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVN 935
Query: 986 VVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQV-----QAQAPDGGPITYHLAAEG 1040
+ V + ++G A S R + T+++ + Q G + + + A+
Sbjct: 936 IQVIPL-SKGRA--IMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD 992
Query: 1041 ASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
F ++ +G L++ LD E Y+ +V+ SK + T + + + +QN+
Sbjct: 993 KDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL--SLSSTVFLSIDVEDQND 1050
Query: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGRLTYSLQQLSEDSKAFRIHPQ 1159
HSP ++ ++V EN P GT V A D D S N R+ Y ++ + + F IHP
Sbjct: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
Query: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGG---SPPRSTTGTVHVAVLDLNDNSPTFLQASG 1216
G + T+ LDRE + L V D + R + T + +LD+ND++PTF+
Sbjct: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN 1170
Query: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT-LTGPGSELFSLHPHSGELLT 1275
A V + V G+LV + A DPDEG NG + Y+ L+G + F L SG L T
Sbjct: 1171 A-------HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTT 1223
Query: 1276 AAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPV 1335
PL + ++LT+ A D G+P S+S L V VL D+ + P
Sbjct: 1224 TCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL----------DVNDEAPVFK-QH 1272
Query: 1336 VLTVTAAEGLRPGSLLGSV-AAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARP 1393
+ + E PG + V A +GV + L + ++ GA E F +++ +G +
Sbjct: 1273 LYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE-LFEINSDTGEVVTTTI 1331
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGA 1453
LD E + + +G + + + V+DEN+HAP F + + EN EP
Sbjct: 1332 LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-E 1390
Query: 1454 ALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLV 1513
+YT ASD D G N V Y ++ ++ +G LS R LDRE L++
Sbjct: 1391 VVYTVLASDMDA-GNNRAVEYHIIDGNTD-ECFTINEMSGELSTTRALDREQISNFTLVI 1448
Query: 1514 EATDRPANASRRRAARVSARVFVTDENDNAPVFAS---PSRVRLPEDQPPGPAALHVVAR 1570
+D R++ + +V V D ND++P F + S VR ED G L + A
Sbjct: 1449 LCSDL---GDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR--EDAEVGTVVLVLSAV 1503
Query: 1571 DPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASD---HGSP 1627
D D G + Y L G F + +G L LDRE R++H + VA D GS
Sbjct: 1504 DKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS- 1562
Query: 1628 PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG 1687
RS T ++ V V DVND P +Q + V L +P + + +RA D D+G NG V +
Sbjct: 1563 -RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFS 1621
Query: 1688 GVSSES-FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
++S FS+D TG + + E I L + D+G P + T + + +E E+
Sbjct: 1622 FAETQSMFSIDKYTGEI-QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV 1680
Query: 1747 HAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGE 1806
+ L + ++ ++A PD ++Y I G+ G L SG+
Sbjct: 1681 KISFSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQ 1739
Query: 1807 FGTMRP--LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEV 1864
P LD EV QL + A G A + V + D ND++P F Y V
Sbjct: 1740 LTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSIYQASV 1796
Query: 1865 PEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCP 1923
E ++Q+ A D D+G NG + Y + +G AF ++ SG + T A LD E
Sbjct: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
Query: 1924 SYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTL-A 1982
SY+ V A D LS T + + V D+ND+AP F LP + +L
Sbjct: 1857 SYSLIVQATD-KGMPRLSNTTVIKVQVTDINDNAPAF--------LPSEAVEITEDSLPG 1907
Query: 1983 LATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDRVLFIVA 2040
+ D N++ ++ A PGT +D TG + + ++ L + + +
Sbjct: 1908 VIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKT---LDFEEMTEYELL 1964
Query: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNG 2100
+ G ++V + + P F + + T+ E+ P G +++ A +N
Sbjct: 1965 IQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDL-ESNE 2023
Query: 2101 PITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRL--------VLQAESGG-- 2150
I+Y ILS +++ FSI P G I F +SP L L +++A GG
Sbjct: 2024 NISYRILSSSKE--FSIDPKNGTI---------FTISPVLLLDTISTTQFLVEASDGGNP 2072
Query: 2151 -AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD-QGSGGQISY 2208
A T++ + ++D N+ AP F Y L E + L+ D D + Y
Sbjct: 2073 DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
Query: 2209 SLAASQPARGLFHVD----------PTTGTITTTAILDREIWAETRLVLMATDRGSPALV 2258
S+ + ++ FHV+ G + LDRE A LV++A+D G P L
Sbjct: 2133 SIISGN-SQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS 2191
Query: 2259 GSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG---PVLWYVLS 2314
+A +++ V+D NDN P + V E LGS I V+ ND D+G +++ ++S
Sbjct: 2192 STAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251
Query: 2315 PSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANLTVLVEDVNDN 2372
+ F + G + L PLD+E+ ++ L + A D H A + V V D ND+
Sbjct: 2252 -GNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDH 2310
Query: 2373 APAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA----------DGF 2422
AP F S + ++ E+ P S I S++A D D+G G ++Y + SP D F
Sbjct: 2311 APQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLF 2370
Query: 2423 SVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSF 2482
+DP G I L ++ + ++A+D G A V V ++ ++ P F
Sbjct: 2371 LIDPLTG---DIHAKQILDYENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIF 2425
Query: 2483 TLSHYRVAVTEDLPPGSTLLTLEATDAD 2510
T Y + E + +EA+DAD
Sbjct: 2426 TQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
Score = 573 bits (1476), Expect = e-162
Identities = 664/2577 (25%), Positives = 1100/2577 (42%), Gaps = 275/2577 (10%)
Query: 388 ISVSDPDDGDFAHVNVSLEGG------EGHFALSTQDSVIYLVCVARRLDREERDA-YNL 440
++ SD D G + + SL G F + D I CV++ +DRE A Y+L
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI---CVSQDIDRERDPATYDL 135
Query: 441 RVTATDSGSPP----------LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
V A D L A+A + + DVNDN P F+ Y + + PG+
Sbjct: 136 LVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTS-ISDETQPGT 194
Query: 491 FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGI----ITTAASLDYELEPQPQL 546
++ V A D D G G V Y L PG + F+ID T+G+ + +++++ + +
Sbjct: 195 EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKE--- 251
Query: 547 IVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQP-GTCFLQVTATDA 605
++ + + LP L V +D E +F+ + +G + +Q A A
Sbjct: 252 VMNSLEMFLPLLRHFKKVE---RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASA 308
Query: 606 DSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGL 665
D +L LG G + T L + ++ V+A DGGGL
Sbjct: 309 DGEAAARYVANLAKILG------------EGIIYLTLPLSHLES-TTLSLMVSAQDGGGL 355
Query: 666 KSMVY--VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723
+++ V + + P +F +Y + P + + ++A +P S + Y
Sbjct: 356 TAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE-PIFYR 414
Query: 724 ILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPG 783
I +G+ F++ + G + PL VV L + A+ G A S V+I+++
Sbjct: 415 ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVMDV 473
Query: 784 TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAV 842
P F + + + PGT++ + +A + GR + S++ P G+F++D
Sbjct: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 532
Query: 843 SGLLQTLRPL----DRELLGPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPA--FP 895
G+L L RE L L +RA GV P A+ + V+++ ++SP+ F
Sbjct: 533 LGVLFLNGSLGAGEQRE-----LTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFE 586
Query: 896 APEDTVLLPPNTAPGTPIYTLRA--LDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRL 952
V + + +P T + +A L P S + ++L A F + P TG + L
Sbjct: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA-SPLRYSLEPSVDSAMFGIRPYTGWIYL 645
Query: 953 MRPLGPSGGPAHELELEA---RDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVD- 1008
R + + A DG L+ V V R NSPT+ D
Sbjct: 646 RRQFDYESTQTYNFRVFAWIPEDG---------FLQNVSTTVIVRVWDENDNSPTFLHDV 696
Query: 1009 ---------LPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG------- 1052
+P G ++ + + G + Y L ++G F + P +G
Sbjct: 697 LFLKVEESPVPQGVIG--KITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGPAGTIYV 752
Query: 1053 --WLWVRA-------ALDREAQELYILKVMAVSGSKAEL--------------------- 1082
W A A + + ++LK + + EL
Sbjct: 753 ITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVT 812
Query: 1083 ----GQQTGTATVRVSILNQNEHSP----RLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134
+ T V VS+ + N++ P L + V E QP V VFA D D
Sbjct: 813 DRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 872
Query: 1135 GPNGRLTYSLQQLSEDSK-AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
G N +TYS+ SEDS F+I GE+ T L + + SY++ V D G PP
Sbjct: 873 GNNAEVTYSVS--SEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQG 930
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDP-DEGENGTI 1252
V++ V+ L+ Q + +P+ + P +++ +++ D + NG +
Sbjct: 931 QAVVNIQVIPLSKGRAIMSQ------NIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL 984
Query: 1253 LYTLTGPGSE-LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQV 1311
+++ + F + +G+L + L HY+ + D S +L L V
Sbjct: 985 HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTD-----HSKNLSLSSTV 1039
Query: 1312 LPSARLAEPPPDLAERDPAAP--VPVVLTVTAAEGLRPGSLLGSVAAPEPAGV---GALT 1366
S D+ +++ +P ++ ++ E + G+L+ A + G +
Sbjct: 1040 FLSI-------DVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
Query: 1367 YTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPG----GAGARLLRV 1422
Y + F + + G L LD E+ P LTV A R L
Sbjct: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRES-IPTVILTVTASDQAVNVTDRRLRSLTA 1151
Query: 1423 QVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPP 1482
Q+ + D N+H P F P A + E+ G+ ++ A D D G N V Y +L
Sbjct: 1152 QIVILDVNDHNPTFISFPNA-HVKEDVTVGSLVHHITAHDPD-EGRNGKVTYSILSGNEN 1209
Query: 1483 VPALRLDARTGALSAPRGLDRETTPALLLLVEATD--RPANASRRRAARVSARVFVTDEN 1540
+ LD +G L+ LD E +L V A D PA +S + + V V D N
Sbjct: 1210 M-TFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQ-----TLTVTVLDVN 1263
Query: 1541 DNAPVFASP-SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSST 1598
D APVF + E+Q PG V A D D G +++ + + G F ++S T
Sbjct: 1264 DEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDT 1323
Query: 1599 GALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLL 1658
G + LDRE + L V+ D G P S+T + +V D ND AP F Y + +
Sbjct: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
Query: 1659 RENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQE 1715
EN P + T+ A+D D G N V Y G + E F+++ +G L+T RALDRE+
Sbjct: 1384 LENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQIS 1442
Query: 1716 EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRA 1774
L + D G PP+ + + ++V V D NDH+P+F + + V E + T+ + L A
Sbjct: 1443 NFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSA 1502
Query: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGG-QP 1833
D D G NGQ +Y + D + SGAF +D SG T LDRE ARD Q
Sbjct: 1503 VDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
Query: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYY 1893
+ S T+++ V V D ND+ P + V + + P + ++A D D G NG V +
Sbjct: 1562 SRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFS 1621
Query: 1894 LGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
A T F ++ +GE++ E P + + D P TT + + +
Sbjct: 1622 F-AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGI--PARTTTGLLVIHMEG 1677
Query: 1954 NDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
D +F + L L T ++ T++A D+ ++ +G ++
Sbjct: 1678 EDVKISF-SHHLYKGLVTENCEAGT---SIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSL 1733
Query: 2014 DSYTGEIRVARSPVALG--PRDRV-LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070
S +G++ V + P L R+ V L ++A G A V+I Q E + P F +
Sbjct: 1734 CSKSGQLTV-KEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLI---QDENDNSPCFEQ 1789
Query: 2071 ASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSA 2129
+ +A++ E+ ++ A G NG I YSILSGN++ F I +G IT ++
Sbjct: 1790 SIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAI 1849
Query: 2130 EGLDFEVSPRLRLVLQAESGGAFAF---TVLTLTLQDANDNAPRFLRPHYVAFLPESRPL 2186
LD+E++ L++QA G TV+ + + D NDNAP FL V +S P
Sbjct: 1850 --LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP- 1906
Query: 2187 EGPLL-QVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRL 2245
G ++ V D+D S S++ ++ + F +D TG + LD E E L
Sbjct: 1907 -GVIVTHVSVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYEL 1963
Query: 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVD 2304
++ +D L V V+D NDN P Q +++ V E +G + ++ D++
Sbjct: 1964 LIQISD---SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020
Query: 2305 SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGP-LDFEQCDRYQLQLLAHDGPHEGRANLT 2363
S + Y + S + FS+ G + P L + Q + A DG + LT
Sbjct: 2021 SNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078
Query: 2364 VL---VEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD-SGANGHISYHLAS-- 2417
++ +ED+N+ AP F+ Y + L E GS +++ S D D + N ++ Y + S
Sbjct: 2079 LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGN 2138
Query: 2418 PADGFSVDP---NNGTLFTIVGTVALGH----DGSGAVDVVLEARDHGAPGRAARATVHV 2470
+ F V+ ++ + VG + L H + S + ++V+ A D G P ++ A + +
Sbjct: 2139 SQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISI 2198
Query: 2471 QLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV 2530
Q+ D ND+ P+F+ Y V E P GS + + A D D + SHA + Y+IISGN
Sbjct: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRD-TGSHAEIIYNIISGNEKGH 2257
Query: 2531 FQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTV 2590
F LE G L L++PLD+E +T++ LTV A+D + S V V
Sbjct: 2258 FYLEEN--------------TGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFV 2302
Query: 2591 TVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS------- 2643
+VLD ND+ P F +S+ VPE+ P+ + + + A D D GP+G + +++ S
Sbjct: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHG 2362
Query: 2644 -GDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDH 2702
LF +D +G + LD E ++ L VQA D A +L V ++++ +++
Sbjct: 2363 MSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLV-VWVDIEGIDEF 2421
Query: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
P F + ++ E L+ + A D DAG G + YSL + P F++N
Sbjct: 2422 EPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP------FFSVNK 2475
Query: 2763 STGE---LRA----RVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPV 2812
+ G +RA + + E T +++ + + + AS TV V V+ E P+
Sbjct: 2476 TNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPL 2532
Score = 570 bits (1469), Expect = e-162
Identities = 535/1871 (28%), Positives = 831/1871 (44%), Gaps = 171/1871 (9%)
Query: 69 PAGTAAPLMYFISAQEGSGV--GTDLAI--DEHSGVVRTAR-------------VLDREQ 111
PAGT +Y I+ +G+ GTD A DE V + LDRE
Sbjct: 746 PAGT----IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREH 801
Query: 112 RDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAA----LQVPEHTAFGTR 161
R + T + D AT+ V V V DIND+ P FPQ ++V E
Sbjct: 802 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 861
Query: 162 YPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
A+D D G Y++S + + + F+++ G E+ T L + R Y
Sbjct: 862 VTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG-------EIRTTTILSYDYRPSY 914
Query: 222 MLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASD 281
+ + A D G PP + QA++++ ++ ++ +Q+ H ++ E+L P + + +SD
Sbjct: 915 RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974
Query: 282 -ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAH 340
NG + + I + DG F ID+ TG L L + LD+E + V D +
Sbjct: 975 HLQQHYNGKLHFSIVA--DDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
Query: 341 PELGSA-FVTVHVRDANDNQPSMT--VIFLSADGSPQVSEAAPPGQLVARISVSDPDDGD 397
L S F+++ V D ND+ PS +I +S V E P G LV + D DDG
Sbjct: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVIS------VEENVPIGTLVYVFNAKD-DDGS 1085
Query: 398 FAHVNV-----SLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG---- 448
F + + S G F + + V RLDRE L VTA+D
Sbjct: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVS---RLDRESIPTVILTVTASDQAVNVT 1142
Query: 449 SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV 508
LR+ A ++ + DVND+ P F + + E GS V +TA DPD+G NG+V
Sbjct: 1143 DRRLRSLTAQIV-ILDVNDHNPTFIS--FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKV 1199
Query: 509 TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVAL 568
TYS+ G F +D +SG++TT LDYE++ Q L V+A D G P L+SS T++V +
Sbjct: 1200 TYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTV 1259
Query: 569 QDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
DVND P F++ Y AS+ E PG +V A D DSG L + + G +
Sbjct: 1260 LDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPG---ASFEL 1316
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFY 686
F I++ +G+V TT LDR+ F V DGG L S + + DEND+ P+F
Sbjct: 1317 FEINSDTGEVVTTTILDREI-QEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
Query: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAW 746
Y + P V + A D D G++ + YHI+ GN+ FT++E SG L+
Sbjct: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
Query: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
L R S L I D G + + ++ P F L Y SV ED G
Sbjct: 1435 ALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVG 1494
Query: 807 TSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEV 865
T V ++ A + L T + G F++D +SG L+T LDRE
Sbjct: 1495 TVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
Query: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGV 925
R S ++V + DVNDN P V L P + +RA D D G
Sbjct: 1555 RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGP 1614
Query: 926 NSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLR 985
N V F+ A F++D TG ++ + P L+L+ D G P RT+
Sbjct: 1615 NGTVVFS-FAETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTT---TG 1669
Query: 986 VVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDG--GPITYHLAAEGASS 1043
++V + + F+ Y+ + AGT ++ V+A APD + Y + +
Sbjct: 1670 LLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDG 1729
Query: 1044 PFGLEPQSGWLWVRAA--LDREAQ-ELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
L +SG L V+ LD E + E+ ++ + SG +A V V I ++N+
Sbjct: 1730 VLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRA-------YCKVAVLIQDEND 1782
Query: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQT 1160
+SP + +V+E+Q V +VFATD DSG NG + YS+ +++ +AF+I +
Sbjct: 1783 NSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE-EAFQIDALS 1841
Query: 1161 GEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGG 1220
G +TT LD E SSY L+VQ D G P S T + V V D+NDN+P FL +
Sbjct: 1842 GVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEA---- 1897
Query: 1221 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL---TGPGSELFSLHPHSGELLTAA 1277
+++ + PG +VT + D D N +++ + PG++ F++ ++G ++
Sbjct: 1898 ---VEITEDSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTK-FAIDQNTGVVVLVK 1951
Query: 1278 PLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL 1337
L E Y L + D A L+V+VL + + PP ++
Sbjct: 1952 TLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLD---VNDNPPVFSQD--------FY 1997
Query: 1338 TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
VT E + G + +++A + ++Y ++ + F++D +G ++ P+
Sbjct: 1998 QVTVPESIPVGYSVLTLSATDLESNENISYRILSSSK---EFSIDPKNGTIFTISPVLLL 2054
Query: 1398 AGPPWRALTVRAEGPGGAGARLLR-VQVQVQDENEHAPAFARDPLALALPENPEPGAALY 1456
V A G R L V++ ++D N +AP F L+L E+ G+ L
Sbjct: 2055 DTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLV 2114
Query: 1457 TFRASDADGPGPNSDVRYRLL---------------RQEPPVPALRLDARTGALSAPRGL 1501
TF D D N+ V Y ++ E P + G L L
Sbjct: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY------KQVGYLVLLHSL 2168
Query: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPP 1560
DRE + + L++ A+D + ++ + V D NDN P F+S S + E P
Sbjct: 2169 DREASASHELVILASD---SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL 2225
Query: 1561 GPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTV 1619
G V A D D G A + Y + SG + GHF L +TG L +++PLD E+ + LTV
Sbjct: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285
Query: 1620 VASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVG 1679
ASD + V+ VSV D ND AP F +S ++ EN P +++ ++ A D D G
Sbjct: 2286 QASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG 2344
Query: 1680 ANGQVTYGGVS-----------SESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728
G++TY VS + F +DP TG + + LD E + LTV A+D+G
Sbjct: 2345 PYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD 2404
Query: 1729 PPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQTLTMLRASDPDVGANGQLQY 1787
+ V V +E ++ P F +PE +D Q + + ASD D G +G + Y
Sbjct: 2405 --ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILY 2462
Query: 1788 RILDGDPSGAFVLDLASGEFGTMRPL-----DREVEPAFQLRIEARDGGQPALSATLLLT 1842
+ G S F ++ +G +R L E +++I A + A+ +
Sbjct: 2463 SL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVF 2520
Query: 1843 VTVLDANDHAP 1853
V V +++ P
Sbjct: 2521 VNVSFSSEGTP 2531
Score = 566 bits (1459), Expect = e-160
Identities = 592/2191 (27%), Positives = 945/2191 (43%), Gaps = 213/2191 (9%)
Query: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211
VPE + GT EP ++ Y +S G F + R G T P
Sbjct: 390 VPEDSPIGTVKAREPLNSSEP-----IFYRISSGDLGGKFSIHPRLGTIRTRKP------ 438
Query: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271
LD E + +L ++A GS P + +++T++D+ND+ PAF ++ +S++ PG
Sbjct: 439 -LDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG 496
Query: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
+ + A D D+G NG + Y I S G F+ID G+L L L ++R L
Sbjct: 497 TALYLARAEDRDSGRNGLIRYSI---ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 553
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEA-APPGQLVARISV 390
++A D G HP+ +TV V + ++ PS T F +VSE+ +P Q++ +
Sbjct: 554 LRAEDQGVHPQAALLVLTV-VIEKREHSPSWT--FEHLVYQVEVSESLSPMTQMLQTQAH 610
Query: 391 SDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG 448
+ + SLE F + IYL R+ D E YN RV A
Sbjct: 611 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL---RRQFDYESTQTYNFRVFAWIPE 667
Query: 449 SPPLR-AEAAFVLHVTDVNDNAPAF--DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTN 505
L+ ++ V D NDN+P F D + E P +P + ++TA D D G N
Sbjct: 668 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESP---VPQGVIGKITAIDMDSGKN 724
Query: 506 GQVTYSLAPGAHTHWFSIDPTSG------IITTA-------------------------- 533
GQ+ Y L + +F ++P +G +IT A
Sbjct: 725 GQLLYFLL--SDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782
Query: 534 ------------ASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
+LD E ++ V+ TD G PP ++ V V++ D+NDN P F +
Sbjct: 783 FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 842
Query: 582 F----YNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
+ + EG V A D D G ++YS+ + S F+IDA++G+
Sbjct: 843 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDHFKIDANNGE 899
Query: 638 VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASIS 695
+ TT L D P S+ +V A D G L+ V + Q P +I
Sbjct: 900 IRTTTILSYDYRP-SYRMSVIATDQGVPPLQGQAVVNI----------QVIPLSKGRAIM 948
Query: 696 AQS----------PPGTAVLRLRAHDP-DQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV 744
+Q+ P + +++ D Q +G+L + I+A + F +D +G L +
Sbjct: 949 SQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFL 1008
Query: 745 AWPLARRANSVVQLEIGAED-GGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDV 803
+ L S + D L + + I + P F+ V SV E+V
Sbjct: 1009 SKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENV 1068
Query: 804 APGTSVGIVQAHNPPGRL--APVTLSLSGGDP-RGLFSLDAVSGLLQTLRPLDRELLGPV 860
GT V + A + G + + + +P F + G L T+ LDRE + V
Sbjct: 1069 PIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTV 1128
Query: 861 LELEVRAGSGVPPAFAVAR---VRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
+ + V R ++++ DVND++P F + + + T G+ ++ +
Sbjct: 1129 ILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTV-GSLVHHIT 1187
Query: 918 ALDPDSGVNSRVTFTLLAGGGG-AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976
A DPD G N +VT+++L+G F +D ++G + PL H L + A D G+P
Sbjct: 1188 AHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTP 1247
Query: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PIT 1033
+S L V V DV AP F Y + G V +V+A D G +
Sbjct: 1248 ALSSSQTLTVTVLDVNDE--APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305
Query: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRV 1093
+ + + F + +G + LDRE QE++ L+V+ G L + T T+
Sbjct: 1306 FEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSL---SSTTTILC 1362
Query: 1094 SILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKA 1153
++ ++N+H+P + V ENQ P V V A+D D+G N + Y + + D +
Sbjct: 1363 TVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTD-EC 1420
Query: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
F I+ +GE++T + LDREQ S++ L++ D G PPRS+ + V VLD ND+SP+F
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 1214 ASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
+ V + GT+V L A D DEG NG Y LT S F++ P SG L
Sbjct: 1481 LYYQS------SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTL 1534
Query: 1274 LTAAPLIRAERPHYVLTLSAHD---QGSPPRSASLQLLV-QVLPSARLAEPPPDLAERDP 1329
T+ L R R + + A D QGS + +++ V V + + E P P
Sbjct: 1535 KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSP 1594
Query: 1330 AAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLY 1389
+P + A+ L G P G ++ A+ + F++D +G +
Sbjct: 1595 ESPTNQTTVIVRADDLDLG----------PNGTVVFSF-----AETQSMFSIDKYTGEIQ 1639
Query: 1390 LARPLDFEAGPPWRALTVRAEG-PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPEN 1448
+ E P W L V +G P LL + ++ +D +F+ + EN
Sbjct: 1640 FQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVK---ISFSHHLYKGLVTEN 1696
Query: 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSA--PRGLDRETT 1506
E G ++ T +A D ++Y + L L +++G L+ P+ LD E
Sbjct: 1697 CEAGTSIVTVKAFAPD--SIQDSMKYSIFSGNED-GVLSLCSKSGQLTVKEPKFLDFEVR 1753
Query: 1507 PALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAAL 1565
+ L+V A S A V + DENDN+P F S + + E Q +
Sbjct: 1754 NEVQLIVLA------ESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVI 1807
Query: 1566 HVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
V A D D G + Y + SG + F++ + +G ++ LD E + + L V A+D
Sbjct: 1808 QVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDK 1867
Query: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQV 1684
G P S T V+ V V D+ND AP F E +V + E++ PG + + D D+ +
Sbjct: 1868 GMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIF 1926
Query: 1685 TYGGVSS--ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742
++ S+ F++D +TGV+ ++ LD EE E L + D T + V V
Sbjct: 1927 SFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVL 1983
Query: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
D ND+ P F + VPE P ++L S D+ +N + YRIL S F +D
Sbjct: 1984 DVNDNPPVFSQDFYQVTVPE-SIPVGYSVLTLSATDLESNENISYRILSS--SKEFSIDP 2040
Query: 1803 ASGEFGTMRP-LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYS 1861
+G T+ P L + Q +EA DGG P L A L+ + + D N++AP F V +Y+
Sbjct: 2041 KNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
Query: 1862 VEVPEDVPAGTLLLQLQAHDPD-AGANGHVTYYLGAGTA-GAFLLE----------PSSG 1909
+ + ED G+ L+ D D N +V Y + +G + F +E G
Sbjct: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
Query: 1910 ELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
L +LDRE S+ + A D + PLS+T ++I V DVND+ P F + +
Sbjct: 2161 YLVLLHSLDREASASHELVILASD-SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHV 2219
Query: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVA 2028
P S T+ + A DRD G++A I+Y ++G ++ TG + + + P+
Sbjct: 2220 KESTPLGSHITV----VSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK-PLD 2274
Query: 2029 LGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
+ V + V+ V + + + P+F +S + EN P + I
Sbjct: 2275 YEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTIC 2334
Query: 2089 SPRAV-HAGGTNGPITYSILS--------GNEKGTFSIQPSTGAITVRSAEGLDFEVSPR 2139
S A+ G G +TYSI+S + F I P TG I + LD+E +
Sbjct: 2335 SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI--LDYENGNK 2392
Query: 2140 LRLVLQA-ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDL 2198
L +QA + G A A V+ + ++ ++ P F + Y LPE + +VEA D
Sbjct: 2393 YCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDA 2452
Query: 2199 DQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229
D G G I YSL S P F V+ T G I
Sbjct: 2453 DAGIDGVILYSLGTSSP---FFSVNKTNGNI 2480
Score = 551 bits (1421), Expect = e-156
Identities = 634/2490 (25%), Positives = 1023/2490 (41%), Gaps = 266/2490 (10%)
Query: 94 IDEHSGVVRTARVLDREQR-------------DRYRFT--AVTPDGATVEVTVRV--ADI 136
ID H G + ++ +DRE+ D R T A+ G + + VRV D+
Sbjct: 111 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDV 170
Query: 137 NDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETR 196
ND+ P F + + + T GT A D D+G GT Y L F +++
Sbjct: 171 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 230
Query: 197 PGPDGTPVPEL-VVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF 255
G V L V D+E + + L R + + F
Sbjct: 231 TGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRF 290
Query: 256 NQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQ 315
R+ L+V A A A Y N + G+G ++
Sbjct: 291 KGRRH-----------LHYLKVQDEAASADGEAAARYVANLAKILGEG---------IIY 330
Query: 316 LERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHV-----RDANDNQPSMTVIFLSAD 370
L PL + L+V A+DGG + +A VT+H+ A +P T +
Sbjct: 331 LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE-- 388
Query: 371 GSPQVSEAAPPGQLVAR--ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVAR 428
V E +P G + AR ++ S+P +S G F++ + + + +
Sbjct: 389 ---DVPEDSPIGTVKAREPLNSSEP-----IFYRISSGDLGGKFSIHPR---LGTIRTRK 437
Query: 429 RLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP 488
LD E + L V A GS P + + V DVNDN PAF R + + P
Sbjct: 438 PLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR-ISQTTPP 495
Query: 489 GSFVVRVTARDPDQGTNGQVTYSLA---PGAHTHWFSIDPTSGIITTAASLDYELEPQPQ 545
G+ + A D D G NG + YS+A PG F+ID G++ SL + +
Sbjct: 496 GTALYLARAEDRDSGRNGLIRYSIASPQPGV----FAIDRALGVLFLNGSLGAGEQRELT 551
Query: 546 LIVVATDGGLPPLASSATVSVALQDVNDNEPQ--FQRTFYNASLPEGTQPGTCFLQVTAT 603
L + A D G+ P A+ ++V ++ ++ P F+ Y + E P T LQ A
Sbjct: 552 LTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 610
Query: 604 DADSGP---FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTA- 659
GP L YSL + S+ F I ++G + R D + +++F V A
Sbjct: 611 PL--GPQRAASPLRYSLEPSVDSA---MFGIRPYTGWIYLRRQFDY-ESTQTYNFRVFAW 664
Query: 660 --VDG--GGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQG 715
DG + + V V+V+ DENDN P F + P + ++ A D D G
Sbjct: 665 IPEDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSG 722
Query: 716 SHGRLSYHILAG--------NSPP---------------------LFTLDEQSGLL---- 742
+G+L Y +L+ N+ P F+ DE +
Sbjct: 723 KNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSL 782
Query: 743 --------TVAW-PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQL 793
+ W L R ++ + D G + V +S+ P F Q
Sbjct: 783 FCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 842
Query: 794 QYVFSVPEDVAPGTSVGI----VQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQT 848
+ V G V + V A +P G A VT S+S D F +DA +G ++T
Sbjct: 843 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRT 902
Query: 849 LRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTA 908
L + + GVPP A V + + ++ +++P N
Sbjct: 903 TTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLK 962
Query: 909 PGTPIYTLRALDP-DSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHEL 966
P + +++ D N ++ F+++A G F +D +TG + L + EL
Sbjct: 963 PTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSK----------EL 1012
Query: 967 ELEARDGGSPPRTSHFRLRVVVQD-----------------VGTRGLAPRFNSPTYRVDL 1009
+ E TSH+ RV+ D +P F + +
Sbjct: 1013 DYET--------TSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
Query: 1010 PSGTTAGTQVLQVQAQAPDG----GPITYHLAAEG-ASSPFGLEPQSGWLWVRAALDREA 1064
GT V A+ DG I Y++ + ++PF + P G L + LDRE+
Sbjct: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
IL V A + ++ + T ++ IL+ N+H+P P V E+ G+ V
Sbjct: 1125 IPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVTVGSLV 1183
Query: 1125 GRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQ 1184
+ A D D G NG++TYS+ ++ F + +G +TT LD E ++ + L V
Sbjct: 1184 HHITAHDPDEGRNGKVTYSILS-GNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLAL 1242
Query: 1185 DGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDP 1244
D G+P S++ T+ V VLD+ND +P F Q A V + PG VT ++A D
Sbjct: 1243 DDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA------SVKENQNPGEFVTRVEALDR 1296
Query: 1245 DEGENGTILY-TLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSA 1303
D G N + + + G ELF ++ +GE++T L R + + L + D G P S+
Sbjct: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSS 1356
Query: 1304 SLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLT--VTAAEGLRPGSLLGSVAAPEPAG 1361
+ +L V + + AP +V + + E P + +A+ AG
Sbjct: 1357 TTTILCTV-------------EDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAG 1403
Query: 1362 VG-ALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLL 1420
A+ Y ++ G E F ++ SG L R LD E + + + ++ + ++
Sbjct: 1404 NNRAVEYHIIDGNTDE-CFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVI 1462
Query: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE 1480
+QV+V D N+H+P+F ++ E+ E G + A D D G N Y L +
Sbjct: 1463 HLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKD-EGLNGQTEYFL--TD 1519
Query: 1481 PPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDEN 1540
A +D +G L LDRE A D S R+ V +V+VTD N
Sbjct: 1520 EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVN 1577
Query: 1541 DNAPVF-ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTG 1599
DN PV +P V L + P + V A D DLG V + A F + TG
Sbjct: 1578 DNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE-TQSMFSIDKYTG 1636
Query: 1600 ALSVVRPLDREQRAEHV---LTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV 1656
+ + +E+ L + +D G P R+ T +L + + + D +F Y
Sbjct: 1637 EIQ----FQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKG 1691
Query: 1657 LLRENNPPGTSLLTLRATDPDVGANGQ--VTYGGVSSESFSLDPDTGVLTTL--RALDRE 1712
L+ EN GTS++T++A PD + + G SL +G LT + LD E
Sbjct: 1692 LVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFE 1751
Query: 1713 EQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT-LTM 1771
+ E+ L V A+ G + V V ++DEND++P F + V E Q +
Sbjct: 1752 VRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
Query: 1772 LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGG 1831
+ A+D D G NG ++Y IL G+ AF +D SG T LD E+ ++ L ++A D G
Sbjct: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
Query: 1832 QPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVT 1891
P LS T ++ V V D ND+APAF +P+ +VE+ ED G ++ + HD D + +
Sbjct: 1869 MPRLSNTTVIKVQVTDINDNAPAF-LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS 1927
Query: 1892 YYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVR 1951
+ + F ++ ++G + LD E+ Y + D T ++ + V
Sbjct: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH----YTEGALVVRVL 1983
Query: 1952 DVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT 2011
DVND+ P F ++ +P P + + L D +N +I YR+ +
Sbjct: 1984 DVNDNPPVFSQDFYQVTVPESIP------VGYSVLTLSATDLESNENISYRILSSSKE-F 2036
Query: 2012 TVDSYTGEIRVARSPVALGPRDRVLFIV-ATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070
++D G I + L F+V A+D G P A ++ +G++ P F
Sbjct: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTV 2096
Query: 2071 ASSEATIRENAPPGTPIVSPRAVHAGGT--NGPITYSILSGNEKGTFSIQ--------PS 2120
S ++ E+A G+ +V+ + T N + YSI+SGN + F ++ P
Sbjct: 2097 KSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Query: 2121 TGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYV 2177
+ LD E S LV+ A G + V+++ + D NDN P F Y
Sbjct: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 2178 AFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDR 2237
+ ES PL + V A+D D GS +I Y++ + +G F+++ TG + LD
Sbjct: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGN-EKGHFYLEENTGVLYLIKPLDY 2275
Query: 2238 EIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIA 2296
E + L + A+D A + V V+D ND+ P + V E+ + S I
Sbjct: 2276 EKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTIC 2334
Query: 2297 QVTGNDVDSGP---VLWYVLSP-------SGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ 2346
+ D D+GP + + ++SP S D F + G + LD+E ++Y
Sbjct: 2335 SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
Query: 2347 LQLLAHDGPHEGRANLTVLV--EDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD 2404
L + A D + A+L V V E +++ P F+Q Y L E I V A+D D
Sbjct: 2395 LTVQAKD-KGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
Query: 2405 SGANGHISYHLASPADGFSVDPNNGTLFTI 2434
+G +G I Y L + + FSV+ NG ++ I
Sbjct: 2454 AGIDGVILYSLGTSSPFFSVNKTNGNIYLI 2483
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 1152 bits (2981), Expect = 0.0
Identities = 895/2945 (30%), Positives = 1397/2945 (47%), Gaps = 194/2945 (6%)
Query: 41 WGQAGSLDLQIDEEQPAGTLI-------GDISAGLPAGTAAPLMYFISAQEGSGVGTDLA 93
+ Q D+ + E P GT + GD+ GT S QE
Sbjct: 582 FSQPEGYDVSVVENAPTGTELLMLRATDGDLGDN---GTVR-----FSLQEAETDRRSFR 633
Query: 94 IDEHSGVVRTARVLDREQRDRYRFTAVT------PDGATVEVTVRVADINDHAPAFPQAR 147
+D SG + T LDRE++ Y + P + + V + DIND++P F +
Sbjct: 634 LDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQ 693
Query: 148 AALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPEL 207
+ E+ G+ A D D G GT Y++S G F++ + G T +
Sbjct: 694 YFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISA-GDRSRFQVNAQSGVISTRMA-- 750
Query: 208 VVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSES 267
LDRE ++ Y LQ+ A DGG+ QA++ +T+LD D+ P F+Q Y VV E+
Sbjct: 751 -----LDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFEN 805
Query: 268 LAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRV 327
+A G V V AS D +N ++Y I +G F+I+ TG L +D E++
Sbjct: 806 VALGYHVGSVSASTMD--LNSNISYLITTGDQKG--MFAINQVTGQLTTANVIDREEQSF 861
Query: 328 HELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVAR 387
++L V A G G V + V+D NDN P FL A S V E G + +
Sbjct: 862 YQLKVVASGGTV---TGDTMVNITVKDLNDNSPH----FLQAIESVNVVENWQAGHSIFQ 914
Query: 388 ISVSDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446
DPD+G V SL + + FA++ ++ I L+ LD +Y + + A+D
Sbjct: 915 AKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLL---GPLD-VHAGSYQIEILASD 970
Query: 447 SGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNG 506
G P L + ++V DVNDN+P FD+ Y L E S +V A D D G NG
Sbjct: 971 MGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVT-LSESEPVNSRFFKVQASDKDSGANG 1029
Query: 507 QVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSV 566
++ Y++A G F I P G + + LD EL+ + L+VVA+D + PL+++ V+V
Sbjct: 1030 EIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTV 1088
Query: 567 ALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGS 626
L+DVNDN P F T Y E + G+ +V+A D D GP G + YS
Sbjct: 1089 ILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSF-----EMVQ 1143
Query: 627 PPFRIDAHSGDVCTTRTLDRD-----QGPSSFDFTVTAVDGG---GLKSMVYVKVFLSDE 678
P F + A SG++ T DR+ +G + F FTV A D G LK V V++ D
Sbjct: 1144 PDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDI 1203
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQ 738
NDN P+F Y A+IS + T VLR+ A D D+G++G + Y I+ GN F +D
Sbjct: 1204 NDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDST 1263
Query: 739 SGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFS 798
SG +T+ L A L I A D G + + ++I I+ P F +
Sbjct: 1264 SGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVD 1323
Query: 799 VPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELL 857
V E++ G V V A + G A + S++G + G FS+ +G + + LD E
Sbjct: 1324 VLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQ 1383
Query: 858 GPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916
+ +L + A G PP + V + + D NDN P+FP + + N GT + ++
Sbjct: 1384 S-LYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442
Query: 917 RALDPDSGVNSRVTFTLLAG--GGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG 974
A DPD+ +N ++++T++ G FT+D G + + EL ++A D
Sbjct: 1443 TAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQA 1502
Query: 975 SPPRTSHFRLR---VVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD--- 1028
P T + L+ ++V D+ P F S PS G+ + + A PD
Sbjct: 1503 VPIETRRYALKNVTILVTDLNDN--VPMFISQNALAADPSAVI-GSVLTTIMAADPDEGA 1559
Query: 1029 GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGT 1088
G I Y + G + F ++ SG L V +AL +Q +Y L V A +LG +
Sbjct: 1560 NGEIEYEII-NGDTDTFIVDRYSGDLRVASALV-PSQLIYNLIVSAT-----DLGPERRK 1612
Query: 1089 ATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLS 1148
+T ++I+ Q P ++ + E +P GT+V + A G + Y + +
Sbjct: 1613 STTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYIVSVR 1671
Query: 1149 EDSKA----FRIHPQTGEVTTLQTLDREQQSSYQLL--VQVQDGGSPPRSTTGTVHVAVL 1202
+ K F I TG + T LDREQ + L+ ++ + PR+ V + +
Sbjct: 1672 CEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQ 1731
Query: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262
D+NDN P F L + V + + G+ + L A D DEG N + YT+ +
Sbjct: 1732 DINDNPPVFPTDM------LDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADD 1785
Query: 1263 LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPP 1322
F + P SG+L+ L R R Y L + A D +S+ +++ + V
Sbjct: 1786 SFRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITV----------S 1832
Query: 1323 DLAERDPAAPVPVVLTVTAAEGLRPGSLLGSV-AAPEPAGV-GALTYTLVGGADPEGTFA 1380
D+ + P PV + E PGSL+ ++ A + +GV G +TY +V D +G F
Sbjct: 1833 DVNDHTPKFSRPVY-SFDIPEDTIPGSLVAAILATDDDSGVNGEITY-IVNEDDEDGIFF 1890
Query: 1381 LDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP 1440
L+ +G L R LD+E + LTVRAE GG +RV + D N++ P F+ +
Sbjct: 1891 LNPITGVFNLTRLLDYEV-QQYYILTVRAED-GGGQFTTIRVYFNILDVNDNPPIFSLNS 1948
Query: 1441 LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
+ +L EN G+ + F +DAD G NS + Y + + + +D + G L +
Sbjct: 1949 YSTSLMENLPVGSTVLVFNVTDADD-GINSQLTYSIASGDS-LGQFTVD-KNGVLKVLKA 2005
Query: 1501 LDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPP 1560
LDRE+ L+V+ D P + R + + + D NDN P F SP +PE+ P
Sbjct: 2006 LDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPI 2065
Query: 1561 GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
A DPD G + + Y L + F + + G + + LDRE+ + + LTVV
Sbjct: 2066 DTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVV 2125
Query: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
A+D G P S++ + V V D+ND P F Q Y V + EN GT ++ + A D D G
Sbjct: 2126 ATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGT 2185
Query: 1681 NGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
NGQV YG G +++ F +D TG +T + LDRE+ +LTV A DRGS P+ TV
Sbjct: 2186 NGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTV 2245
Query: 1738 RVAVEDENDHAPTFGSAHLSLEVPE--GQDPQTLTMLRASDPDVGANGQLQYRILDGDPS 1795
+ + D ND P F + S+ VPE G P+T+ + A D D G+N +L Y + G+
Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNED 2305
Query: 1796 GAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAF 1855
AF L ASGE G + LDRE + F L I A D G PAL+ T + V V D ND+ P F
Sbjct: 2306 NAFTLS-ASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTF 2364
Query: 1856 PVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAA 1915
AY +PED P GT +L + A D DA N + G F + PS+G++ T+A
Sbjct: 2365 ASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRI---IGGNSQFTINPSTGQIITSA 2421
Query: 1916 ALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPS 1975
LDRE +YT V D + PLS++ SV +TV DVND+ P F P +P P
Sbjct: 2422 LLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSP--- 2478
Query: 1976 FSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV 2035
+ P + + D D G N+ + Y L+G +D G I +A P+ G +
Sbjct: 2479 -TLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAI-MAAGPLN-GASEVT 2535
Query: 2036 LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRA-SSEATIR--ENAPPGTPIVSPRA 2092
+ D G ++ + + V +A+ FP+ + E T EN P + + +
Sbjct: 2536 FSVHVKDGGSFPKTDSTTVTVRFVNKAD----FPKVRAKEQTFMFPENQPVSSLVTTITG 2591
Query: 2093 VHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAF 2152
G P++Y I SGN TF I TG +++ ++ LDFE + + ++A GG
Sbjct: 2592 SSLRGE--PMSYYIASGNLGNTFQIDQLTGQVSI--SQPLDFEKIQKYVVWIEARDGGFP 2647
Query: 2153 AFT---VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYS 2209
F+ L +T+ D NDNAP F +++ + E+ +L V A D D G GQ+ Y
Sbjct: 2648 PFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLS-PRKILTVSAMDKDSGPNGQLDYE 2706
Query: 2210 LAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVID 2269
+ F ++ TG I + LDRE + L + ++D+GSP+ S + + ++D
Sbjct: 2707 IVNGN-MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILD 2765
Query: 2270 TNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG 2329
NDN P Q + V E++ LG + +VT +D D G S PF++ G
Sbjct: 2766 ENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTG 2825
Query: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHT 2389
+ ++ PL+ E DRY++++ AHD ++T+ V D+NDNAP FS++ Y + E T
Sbjct: 2826 DIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELT 2885
Query: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVD 2449
GS + V ATD D G+NG + Y + S ++ F ++ G +F G V+
Sbjct: 2886 EIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVN 2945
Query: 2450 V-----VLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
+ ++ + D G P + TV + + D ND+AP F S Y VT+++ G+ L+ +
Sbjct: 2946 INRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRV 3005
Query: 2505 EATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFES 2564
A D ++ V+Y I + N F+L+ G + + L +
Sbjct: 3006 TAIDDKDFGLNSEVEYFISNDNHLGKFKLD--------------NDTGWISVASSLISDL 3051
Query: 2565 LTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHV 2624
+ +TV A D+G PP SS V +TV + N + P F+++ T+PE +G+ + V
Sbjct: 3052 NQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV 3111
Query: 2625 EASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG 2684
A D D +GL+++++SSG+ G+F ++ S+G L LA ALD E +H++ + A D
Sbjct: 3112 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW 3171
Query: 2685 -AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRY 2743
A VT+ V DVND+ P F + +V EN P GT V L+A D D+G + Y
Sbjct: 3172 VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAY 3231
Query: 2744 SLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSV 2801
++ + + F ++ +TG + + D+E +S+ L V A + + + TV++
Sbjct: 3232 TVQSS-----DSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNI 3286
Query: 2802 LVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS--PYF 2859
+ G +EY P F++ ++F++ E A +G +G V A+D D G DG V Y + +S F
Sbjct: 3287 QLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGF 3346
Query: 2860 GINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIAR--GPLPGSRSATVP 2917
IN+ TG +Y+ G RE + L+V+A+ G + G+ V
Sbjct: 3347 QINKKTGQIYV----------------SGILDREKEERVSLKVLAKNFGSIRGADIDEVT 3390
Query: 2918 VTVDI 2922
V V +
Sbjct: 3391 VNVTV 3395
Score = 1116 bits (2886), Expect = 0.0
Identities = 916/2936 (31%), Positives = 1389/2936 (47%), Gaps = 188/2936 (6%)
Query: 12 PGMKSPRPHLLLPLL----LLLLLLLGAGVPG-AW--GQAGSLDLQIDEEQPAGTLIGDI 64
P + RP L L L LL + L + +PG AW G Q+ EEQP GTL+G I
Sbjct: 5 PDRATGRPWLPLHTLSVSQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTI 64
Query: 65 SAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDG 124
T Y +S AI+ +G + T +DRE V
Sbjct: 65 Q------TRPGFTYRLSESHAL-----FAINSSTGALYTTSTIDRESLPSDVINLVVLSS 113
Query: 125 ATV---EVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYA 181
A EV V V D+ND+AP FP + E ++ G + L+ A D+D G G +
Sbjct: 114 APTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRS 173
Query: 182 ---LSGDGAGETFRLETRPGPDGTPV-PELVVTGELDRENRSHYMLQLEAYDGGSPPRRA 237
+ G+ AG FRL+ P G LV G LDRE Y L +E D G P RR
Sbjct: 174 YRIIRGNEAGR-FRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRG 232
Query: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297
++VT+ DIND+ P F S Y A V E GS VLQV A+DAD G N + Y R
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRY---RL 289
Query: 298 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357
Q EG PF +D TGL+ + PLDFE RR + L VQA D G G A + + D ND
Sbjct: 290 QDEGT-PFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVND 348
Query: 358 NQPSMTVIFLSADGS-PQVSEAAPPGQLVARISVSDPDD-GDFAHVNVSLEGG--EGHFA 413
N P + + A V E A G +VA ++V+D D +++V + GG + HF
Sbjct: 349 NDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFE 408
Query: 414 L-STQDSVIYLVCVARRLDREERDAYNLRVTATDS-GSPPLRA------EAAFVLHVTDV 465
+ S++ + L+ VA LDRE +YNL V+ +D+ G+PP A A+ V+ V D+
Sbjct: 409 VQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDI 468
Query: 466 NDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDP 525
ND+ P F +Q+YR L E A PGS+V ++A D D G N + YS+ G WF I
Sbjct: 469 NDHPPVFSQQVYRVN-LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISE 527
Query: 526 TSGIITTAAS--LDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQF-QRTF 582
SG++TT +S LD EL Q L + A D G+ P S A + V L DVND +P F Q
Sbjct: 528 HSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEG 587
Query: 583 YNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTR 642
Y+ S+ E GT L + ATD D G G + +SL + FR+D SG + T
Sbjct: 588 YDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQE--AETDRRSFRLDPVSGRLSTIS 645
Query: 643 TLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPP 700
+LDR++ + + V A D G SM + V L D NDN P FYP +Y A I P
Sbjct: 646 SLDREE-QAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPG 704
Query: 701 GTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEI 760
G+ + + A DPD G++G + Y I AG+ F ++ QSG+++ L R + QL+I
Sbjct: 705 GSYITTVSATDPDLGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDREEKTAYQLQI 763
Query: 761 GAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGR 820
A DGG LQ+ A V I+++ PP+F Q+ Y F V E+VA G VG V A +
Sbjct: 764 VATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSA-STMDL 822
Query: 821 LAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARV 880
+ ++ ++ GD +G+F+++ V+G L T +DRE +L+V A G + V
Sbjct: 823 NSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQS-FYQLKVVASGGTVTGDTM--V 879
Query: 881 RVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA 940
+ + D+NDNSP F ++V + N G I+ +A+DPD GVN V ++L
Sbjct: 880 NITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNL 939
Query: 941 FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRF 1000
F ++ G + L+ PL G ++++E+ A D G P +S L V V DV +P F
Sbjct: 940 FAINEKNGTISLLGPLDVHAG-SYQIEILASDMGVPQLSSSVILTVYVHDVNDN--SPVF 996
Query: 1001 NSPTYRVDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVR 1057
+ +Y V L ++ +VQA D G I Y +A FG+ P G L+++
Sbjct: 997 DQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIK 1055
Query: 1058 AALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAEN 1117
+ LDRE Q+ Y+L V+A S + + T V V + + N++ P + E
Sbjct: 1056 SELDRELQDRYVLMVVA---SDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEE 1112
Query: 1118 QPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQ---- 1173
Q G+ VG+V A D+D GPNG + YS + + D F +H +GE+T DRE
Sbjct: 1113 QRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPD---FELHAISGEITNTHQFDRESLMRR 1169
Query: 1174 --QSSYQLLVQVQDGGSP-PRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRV 1230
+ + V D G P P TVHV + D+NDN+P FL+ A + +
Sbjct: 1170 RGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQA------TISESA 1223
Query: 1231 PPGTLVTTLQAKDPDEGENGTILYT-LTGPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289
T V + A D DEG NG I Y+ + G F++ SG++ L P Y L
Sbjct: 1224 ANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSL 1283
Query: 1290 TLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGS 1349
+ A D G+ P +++ L + +L D + P+ P L V E +R G
Sbjct: 1284 VIQAVDSGTIPLNSTCTLNIDIL----------DENDNTPSFP-KSTLFVDVLENMRIGE 1332
Query: 1350 LLGSVAAPE-PAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVR 1408
L+ SV A + +G A Y + G + GTF++ +G ++LA+ LDFE ++ L +
Sbjct: 1333 LVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYK-LNIT 1391
Query: 1409 AEGPG-GAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPG 1467
A+ G + + V + V+D N++ P+F + ++ EN G ++ + A D D
Sbjct: 1392 AKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDA-D 1450
Query: 1468 PNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRA 1527
N + Y +++Q P +D G + +DRE L V+A D+ RR
Sbjct: 1451 INGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRY 1510
Query: 1528 ARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG 1587
A + + VTD NDN P+F S + + G ++A DPD G + Y + +G
Sbjct: 1511 ALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIING 1570
Query: 1588 GDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAP 1647
F + +G L V L Q + L V A+D G R +T LT+ + + + P
Sbjct: 1571 DTDTFIVDRYSGDLRVASALVPSQLI-YNLIVSATDLGPERRKSTTELTIILQGL--DGP 1627
Query: 1648 TFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS--------SESFSLDPD 1699
F Q +Y +L+E P GT+++++ A P G+ V Y VS F++
Sbjct: 1628 VFTQPKYITILKEGEPIGTNVISIEAASPR-GSEAPVEYYIVSVRCEEKTVGRLFTIGRH 1686
Query: 1700 TGVLTTLRALDREEQEEINLT-VYAQDRGSP-PQLTHVTVRVAVEDENDHAPTFGSAHLS 1757
TG++ T LDRE+ + L VYA ++ + P+ V + ++D ND+ P F + L
Sbjct: 1687 TGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLD 1746
Query: 1758 LEVPEG-QDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDRE 1816
L V E D + L A D D GAN + Y I+ G +F +D SG+ R LDRE
Sbjct: 1747 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRE 1805
Query: 1817 VEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQ 1876
+ L + A DG Q S+ + + +TV D NDH P F P YS ++PED G+L+
Sbjct: 1806 RRSKYSLLVRADDGLQ---SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAA 1862
Query: 1877 LQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGA 1935
+ A D D+G NG +TY + G F L P +G LD E Y +V A DG
Sbjct: 1863 ILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDG- 1921
Query: 1936 AAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGA 1995
G TT+ V + DVND+ P F + L P ST + D D G
Sbjct: 1922 --GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGST----VLVFNVTDADDGI 1975
Query: 1996 NASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGR-PAR--SATG 2052
N+ + Y +A G G ++V ++ L + DL + PA ++T
Sbjct: 1976 NSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTA 2035
Query: 2053 VIIVGLQGEAERGPRFPRASSEAT-IRENAPPGTPIVSPRAVHA-GGTNGPITYSILS-- 2108
+ + L + P F S + T I EN P T + +A G N I Y++L+
Sbjct: 2036 QVSIILLDVNDNPPTF--LSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPL 2093
Query: 2109 GNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDAN 2165
GN+ FSI G VR LD E L + A G + T + + + D N
Sbjct: 2094 GNK---FSIGTIDG--EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDIN 2148
Query: 2166 DNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPT 2225
DN P F + Y + E+ ++QV A D D+G+ GQ+ Y + + F +D
Sbjct: 2149 DNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE-FRIDSV 2207
Query: 2226 TGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELR 2284
TG IT LDRE L + ATDRGS ++T++++++D ND P P+ +
Sbjct: 2208 TGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVN 2267
Query: 2285 VSED-ALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQ 2341
V E+ L I QV D D G L YVL + F++ G + +T LD E
Sbjct: 2268 VPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRET 2326
Query: 2342 CDRYQLQLLAHDGPH---EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398
+R+ L + A D G + V+V+DVNDN P F+ Y + E P G+ +L V
Sbjct: 2327 KERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLV 2386
Query: 2399 SATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHG 2458
+A+D D+ N I + F+++P+ G + T + L + +V+ D G
Sbjct: 2387 NASDADASKNAVI--RIIGGNSQFTINPSTGQIIT---SALLDRETKDNYTLVVVCSDAG 2441
Query: 2459 APGRAARAT-VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA 2517
+P + +T V V + D ND+ P F Y + PGS + + TDAD ++
Sbjct: 2442 SPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDAD-IGPNSE 2500
Query: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADR 2577
+ YS +SG F ++P L A +AGP ++ +V D
Sbjct: 2501 LHYS-LSGRNSEKFHIDP-LRGAIMAAGP---------------LNGASEVTFSVHVKDG 2543
Query: 2578 GQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLV 2637
G P++ VTV ++ D P V + PE+ PV + + + S P +
Sbjct: 2544 GSFPKTDSTTVTVRFVNKADFPKVRAK-EQTFMFPENQPVSSLVTTITGSSLRGEP---M 2599
Query: 2638 RFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEV 2696
+ ++SG+ F++D+ +G + ++ LD E ++ + ++A D F + + I V
Sbjct: 2600 SYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITV 2659
Query: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
DVND+ P F + + + EN P ++ T+ A+D D+G G+L Y ++
Sbjct: 2660 LDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEIVNGNM----EN 2714
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFL 2814
+F++N +TGE+R+ P D E + L + ++D G+ S S +V V++ DE D P F
Sbjct: 2715 SFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF- 2773
Query: 2815 APAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
+ F VPE + G+++ V +DED G + + YS+ +S F IN +TG + +
Sbjct: 2774 SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVI 2829
Score = 933 bits (2411), Expect = 0.0
Identities = 839/2894 (28%), Positives = 1314/2894 (45%), Gaps = 209/2894 (7%)
Query: 53 EEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR 112
E G +G +SA + + Y I+ + G+ AI++ +G + TA V+DRE++
Sbjct: 804 ENVALGYHVGSVSAST-MDLNSNISYLITTGDQKGM---FAINQVTGQLTTANVIDREEQ 859
Query: 113 DRYRFTAVTPDGATVE---VTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARD 169
Y+ V G V + V D+ND++P F QA ++ V E+ G A D
Sbjct: 860 SFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVD 919
Query: 170 ADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYD 229
D G G Y+L F + + G + + G LD S Y +++ A D
Sbjct: 920 PDEGVNGMVLYSLK-QNPKNLFAINEKNGT-------ISLLGPLDVHAGS-YQIEILASD 970
Query: 230 GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGA 289
G P + +L V + D+ND++P F+Q Y +SES S +V ASD D+G NG
Sbjct: 971 MGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGE 1030
Query: 290 VTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVT 349
+ Y I + GD F I G L ++ LD E + + L+V A D P + VT
Sbjct: 1031 IAYTIAEGNT-GDA-FGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVT 1087
Query: 350 VHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGE 409
V + D NDN+P +F S + + E G V ++S D D G V S E +
Sbjct: 1088 VILEDVNDNRP----LFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQ 1143
Query: 410 GHFALSTQDSVIYLVCVARRLDREE------RDAYNLRVTATDSGSP-PLRAEAAFVLHV 462
F L I + DRE ++ V ATD G P PL+ +A +++
Sbjct: 1144 PDFELHAISGEI---TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYM 1200
Query: 463 TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFS 522
D+NDNAP F + Y+ + E A + V+RV+A D D+G NG + YS+ G F+
Sbjct: 1201 KDINDNAPKFLKDFYQAT-ISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFA 1259
Query: 523 IDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTF 582
ID TSG +T LDYE P L++ A D G PL S+ T+++ + D NDN P F ++
Sbjct: 1260 IDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKST 1319
Query: 583 YNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTR 642
+ E + G VTATD+DSG L YS+ G++ F I ++G + +
Sbjct: 1320 LFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI---TGTNNHGTFSISPNTGSIFLAK 1376
Query: 643 TLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPP 700
LD + S + +TA D G S + V + + D NDNPP F P + SI P
Sbjct: 1377 KLDFET-QSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPI 1435
Query: 701 GTAVLRLRAHDPDQGSHGRLSYHILA----GNSPPLFTLDEQSGLLTVAWPLARRANSVV 756
GT+V+ + AHDPD +G+LSY I+ GN FT+DE G + + R ++
Sbjct: 1436 GTSVISVTAHDPDADINGQLSYTIIQQMPRGNH---FTIDEVKGTIYTNAEIDREFANLF 1492
Query: 757 QLEIGAEDGGGLQAEPSA-------RVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSV 809
+L + A D QA P V I + P+F + + P V
Sbjct: 1493 ELTVKAND----QAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLT 1548
Query: 810 GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGS 869
I+ A G + + GD F +D SG L+ L L + L V A
Sbjct: 1549 TIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVASALVPSQL--IYNLIVSATD 1605
Query: 870 -GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSR 928
G + + ++L ++ P F P+ +L GT + ++ A P G +
Sbjct: 1606 LGPERRKSTTELTIILQGLD--GPVFTQPKYITILKEGEPIGTNVISIEAASP-RGSEAP 1662
Query: 929 VTFTLLAGG------GGAFTVDPTTGHVRLMRPLGPSGGPA-HELELEARDGGSP-PRTS 980
V + +++ G FT+ TG ++ L G + +++ A + + PRT
Sbjct: 1663 VEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQ 1722
Query: 981 HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLA 1037
+ + +QD+ P F + + + G++++Q+ A D G +TY +
Sbjct: 1723 RAEVEITLQDINDN--PPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTII 1780
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ GA F ++P+SG L LDRE + Y L V +A+ G Q+ + +++ +
Sbjct: 1781 S-GADDSFRIDPESGDLIATRRLDRERRSKYSLLV------RADDGLQSSDMRINITVSD 1833
Query: 1098 QNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIH 1157
N+H+P+ S + E+ PG+ V + ATD DSG NG +TY + + ED F ++
Sbjct: 1834 VNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDG-IFFLN 1892
Query: 1158 PQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGA 1217
P TG + LD E Q Y L V+ +DGG + TT V+ +LD+NDN P F S +
Sbjct: 1893 PITGVFNLTRLLDYEVQQYYILTVRAEDGGG--QFTTIRVYFNILDVNDNPPIFSLNSYS 1950
Query: 1218 AGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAA 1277
+ + +P G+ V D D+G N + Y++ S +G L
Sbjct: 1951 TS------LMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLK 2004
Query: 1278 PLIRAERPHYVLTLSAHDQGSPPRSASLQLL-VQVLPSARLAEPPPDLAERDPAAP--VP 1334
L R + Y L + HD P S V ++ PP L+ + P P
Sbjct: 2005 ALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTP 2064
Query: 1335 VVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT-FALDAASGRLYLARP 1393
+ V A+ P S S + YTL+ +P G F++ G + L
Sbjct: 2065 IDTVVFKAQATDPDSGPNSY----------IEYTLL---NPLGNKFSIGTIDGEVRLTGE 2111
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGA 1453
LD E + V + + + V V V D N++ P FA+ + + EN G
Sbjct: 2112 LDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGT 2171
Query: 1454 ALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLV 1513
+ A+D D G N VRY ++ R+D+ TGA++ + LDRE TP L V
Sbjct: 2172 DIIQVFAADGD-EGTNGQVRYGIVNGNTN-QEFRIDSVTGAITVAKPLDREKTPTYHLTV 2229
Query: 1514 EATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAA-LHVVARD 1571
+ATDR S R + + + D ND PVF SP V +PE+ P L VVARD
Sbjct: 2230 QATDR---GSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARD 2286
Query: 1572 PDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSA 1631
D G +++SY L G + + S++G L V + LDRE + VL + A+D GSP +
Sbjct: 2287 DDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTG 2346
Query: 1632 TQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSS 1691
T + V V DVND PTF + Y + E+ P GT +L + A+D D N + G +S
Sbjct: 2347 TGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNS 2406
Query: 1692 ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVT-VRVAVEDENDHAPT 1750
+ F+++P TG + T LDRE ++ L V D GSP L+ T V V V D ND+ P
Sbjct: 2407 Q-FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPR 2465
Query: 1751 FGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGT 1809
F +P P + + +D D+G N +L Y L G S F +D G
Sbjct: 2466 FQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRNSEKFHIDPLRGAIMA 2524
Query: 1810 MRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVP 1869
PL+ E F + + +DGG + + +TV ++ D P + PE+ P
Sbjct: 2525 AGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPENQP 2581
Query: 1870 AGTLLLQLQAHDPDAGANGH-VTYYLGAGTAG-AFLLEPSSGELRTAAALDREQCPSYTF 1927
+L+ + + G ++YY+ +G G F ++ +G++ + LD E+ Y
Sbjct: 2582 VSSLVTTITG----SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVV 2637
Query: 1928 SVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR 1987
+ A DG P S+ + ITV DVND+AP F P + + + T+
Sbjct: 2638 WIEARDGGFP-PFSSYEKLDITVLDVNDNAPIFKEDPFISEILE-----NLSPRKILTVS 2691
Query: 1988 AEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARSPVALGPRDR------VLFIVA 2040
A D+D+G N + Y + G +++ TGEIR R P DR VL I +
Sbjct: 2692 AMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVR------PLDREKVSHYVLTIKS 2745
Query: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTN 2099
+D G P++S + +++ + E + PRF + S A + EN+P G + G N
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRFSQIFS-AHVPENSPLGYTVTRVTTSDEDIGIN 2804
Query: 2100 GPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTL 2159
YSI+ + F+I PSTG I + + L+ E + R R+ + A G T +T+
Sbjct: 2805 AISRYSIMDASLP--FTINPSTGDIVI--SRPLNREDTDRYRIRVSAHDSGWTVSTDVTI 2860
Query: 2160 TLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL 2219
+ D NDNAPRF R Y PE + + QV A D D+GS GQ+ Y + +
Sbjct: 2861 FVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE---Y 2917
Query: 2220 FHVDPTTGTITTTAILDREIWA--------ETRLVLMATDRGSPALVGSATLTVMVIDTN 2271
F ++ TTG I IL + ++ ++DRG P+L+ T+T+ ++D+N
Sbjct: 2918 FRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSN 2977
Query: 2272 DNRPT-IPQPWELRVSEDALLGSEIAQVTG-NDVDSG--PVLWYVLSPSGPQDPFSVGRY 2327
DN P + + V+++ +G+++ +VT +D D G + Y +S F +
Sbjct: 2978 DNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDND 3037
Query: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVM 2384
G +S+ L + + + + A D P +A + + V + N + P FSQS
Sbjct: 3038 TGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT 3097
Query: 2385 LLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTIVGTVALGH 2442
+ E GS + +VSA DRD+ NG I Y ++S + F+++ + G L AL +
Sbjct: 3098 IPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTL---AKALDY 3154
Query: 2443 DGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLL 2502
+ ++ + A D G R +V V + D ND++P F Y V E+ P G+T++
Sbjct: 3155 ELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVI 3214
Query: 2503 TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
L ATDAD S ++A + Y++ S + +F ++P G + LDF
Sbjct: 3215 HLNATDAD-SGTNAVIAYTVQSSD-SDLFVIDPNT--------------GVITTQGFLDF 3258
Query: 2563 ESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELL 2622
E+ Y+LTV A + + S V + + N+ P F Y + E P G +
Sbjct: 3259 ETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVG 3318
Query: 2623 HVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADP 2682
V ASD D G G V + + F++++ +G + ++ LD E + R L V A +
Sbjct: 3319 EVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNF 3378
Query: 2683 A---GAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA-GAF 2738
GA V + V D ND P F LN+ S ++E P GT VT + A D D+ ++
Sbjct: 3379 GSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSW 3437
Query: 2739 GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVT 2798
R Y + G G E AF++N TG++ D E + L V A D+G SA+ +
Sbjct: 3438 SRFSYFI---GSGNENG-AFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGS 3493
Query: 2799 VSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDED----GGADGLVLYSLAT 2854
S+LVT ED D + +V E R G + +Q+TD D G L S
Sbjct: 3494 ASLLVTLEDINDNGPMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGP 3553
Query: 2855 SSPYFGINQTTGAL 2868
++ YF ++ T G L
Sbjct: 3554 ATSYFSLS-TAGVL 3566
Score = 879 bits (2270), Expect = 0.0
Identities = 768/2628 (29%), Positives = 1216/2628 (46%), Gaps = 206/2628 (7%)
Query: 52 DEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRE 110
+EEQ AG+ +G +SA G + Y V D + SG + DRE
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM-----VQPDFELHAISGEITNTHQFDRE 1164
Query: 111 QRDRYRFTAV---------------TPDGATVEVTVRVADINDHAPAFPQARAALQVPEH 155
R R TAV D ATV V ++ DIND+AP F + + E
Sbjct: 1165 SLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMK--DINDNAPKFLKDFYQATISES 1222
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
A T+ A D D G G Y++ F +++ G ++ + G+LD
Sbjct: 1223 AANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSG-------QVTLIGKLDY 1275
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E Y L ++A D G+ P + L++ +LD ND+ P+F +S V E++ G V
Sbjct: 1276 EATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVS 1335
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
V A+D+D+G N + Y I + G FSI +TG + L + LDFE + +++L + A+
Sbjct: 1336 SVTATDSDSGDNADLYYSITGTNNHGT--FSISPNTGSIFLAKKLDFETQSLYKLNITAK 1393
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPD- 394
D G P + V +HVRD NDN PS F D + E P G V ++ DPD
Sbjct: 1394 DQGRPPRSSTMSVVIHVRDFNDNPPS----FPPGDIFKSIVENIPIGTSVISVTAHDPDA 1449
Query: 395 --DGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452
+G ++ + HF + IY +DRE + + L V A D P
Sbjct: 1450 DINGQLSYTIIQQMPRGNHFTIDEVKGTIY---TNAEIDREFANLFELTVKANDQAVPIE 1506
Query: 453 RAEAAF---VLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
A + VTD+NDN P F Q A+ GS + + A DPD+G NG++
Sbjct: 1507 TRRYALKNVTILVTDLNDNVPMFISQ--NALAADPSAVIGSVLTTIMAADPDEGANGEIE 1564
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y + G T F +D SG + A++L + LIV ATD G S+ +++ LQ
Sbjct: 1565 YEIING-DTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQ 1622
Query: 570 DVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATD--ADSGPFGLLSYSLGAGLGSSGSP 627
++ P F + Y L EG GT + + A P S+ + G
Sbjct: 1623 GLDG--PVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRL 1680
Query: 628 PFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVY-------VKVFLSDEND 680
F I H+G + T LDR+QG + V A++ KS + V++ L D ND
Sbjct: 1681 -FTIGRHTGIIQTAAILDREQGACLYLVDVYAIE----KSTAFPRTQRAEVEITLQDIND 1735
Query: 681 NPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSG 740
NPP F ++ G+ +++L A D D+G++ ++Y I++G + F +D +SG
Sbjct: 1736 NPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESG 1794
Query: 741 LLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVP 800
L L R S L + A+DG LQ+ R++I++ P F + Y F +P
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDG--LQSS-DMRINITVSDVNDHTPKFSRPVYSFDIP 1851
Query: 801 EDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP 859
ED PG+ V + A + G +T ++ D G+F L+ ++G+ R LD E+
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQY 1911
Query: 860 VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRAL 919
+ L VRA G F RV + DVNDN P F + L N G+ +
Sbjct: 1912 YI-LTVRAEDG-GGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVT 1969
Query: 920 DPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
D D G+NS++T+++ +G G FTVD G +++++ L + L ++ D P
Sbjct: 1970 DADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPA 2028
Query: 979 ---TSHFRLRVVVQDVGTRGLAPRFNSP--TYRVDLPSGTTAGTQVLQVQAQAPDGGPIT 1033
TS ++ +++ DV P F SP TY +P T T V + QA PD GP +
Sbjct: 2029 SRFTSTAQVSIILLDVNDN--PPTFLSPKLTY---IPENTPIDTVVFKAQATDPDSGPNS 2083
Query: 1034 Y--HLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATV 1091
Y + + F + G + + LDRE Y L V+A + L T V
Sbjct: 2084 YIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSST---EV 2140
Query: 1092 RVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDS 1151
V +L+ N+++P ++ + + EN GT + +VFA D D G NG++ Y + +
Sbjct: 2141 VVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN-GNTN 2199
Query: 1152 KAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF 1211
+ FRI TG +T + LDRE+ +Y L VQ D GS PR+ T TV + +LD+ND P F
Sbjct: 2200 QEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVF 2259
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQ---AKDPDEGENGTILYTLTGPGSELFSLHP 1268
+ + + VP+ + GTL T+ A+D D G N + Y L G +
Sbjct: 2260 ELSPYS------VNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS 2311
Query: 1269 HSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERD 1328
SGEL L R + +VL ++A D GSP + + + V V D+ +
Sbjct: 2312 ASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIV----------DDVNDNV 2361
Query: 1329 PAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRL 1388
P T T E G+ + V A + ++GG F ++ ++G++
Sbjct: 2362 PTFASKAYFT-TIPEDAPTGTDVLLVNASDADASKNAVIRIIGG---NSQFTINPSTGQI 2417
Query: 1389 YLARPLDFEAGPPWRALTVRAE-GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPE 1447
+ LD E + + V ++ G + V V V D N++ P F P +P
Sbjct: 2418 ITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPS 2477
Query: 1448 NPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTP 1507
PG+ ++ +DAD GPNS++ Y L + +D GA+ A L+ +
Sbjct: 2478 PTLPGSFVFAVTVTDAD-IGPNSELHYSLSGRNSE--KFHIDPLRGAIMAAGPLNGASEV 2534
Query: 1508 ALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHV 1567
+ V+ S + + V ++ D V A PE+QP +
Sbjct: 2535 TFSVHVKD-----GGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTI 2589
Query: 1568 VARDPDLGEAAR---VSYRLASGGDGH-FRLHSSTGALSVVRPLDREQRAEHVLTVVASD 1623
G + R +SY +ASG G+ F++ TG +S+ +PLD E+ ++V+ + A D
Sbjct: 2590 T------GSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARD 2643
Query: 1624 HGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQ 1683
G PP S+ + L ++V DVND AP F++ + + EN P +LT+ A D D G NGQ
Sbjct: 2644 GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQ 2702
Query: 1684 VTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
+ Y G SFS++ TG + ++R LDRE+ LT+ + D+GSP Q T V V +
Sbjct: 2703 LDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMIN 2762
Query: 1741 VEDENDHAPTFG---SAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGA 1797
+ DEND+AP F SAH+ P G T+T + SD D+G N +Y I+D S
Sbjct: 2763 ILDENDNAPRFSQIFSAHVPENSPLGY---TVTRVTTSDEDIGINAISRYSIMDA--SLP 2817
Query: 1798 FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPV 1857
F ++ ++G+ RPL+RE +++R+ A D G + + +T+ V D ND+AP F
Sbjct: 2818 FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDINDNAPRFSR 2874
Query: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL 1917
+Y ++ PE G+ + Q+ A DPD G+NG V Y++ + + F + ++GE+ L
Sbjct: 2875 TSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE-YFRINATTGEIFNKQIL 2933
Query: 1918 DREQCPSYT--------FSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
+ ++ F V++ D +S T +VTI + D ND+AP F S +
Sbjct: 2934 KYQNVTGFSNVNINRHSFIVTSSDRGKPSLISET-TVTINIVDSNDNAPQFLKSKYFTPV 2992
Query: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVA 2028
+ + T + +D+D G N+ + Y ++ G +D+ TG I VA S ++
Sbjct: 2993 TK---NVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLIS 3049
Query: 2029 LGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI- 2087
++ + + A D G P S+ + + + E P F ++ ATI E+ G+ +
Sbjct: 3050 DLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR 3109
Query: 2088 -VSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA 2146
VS R A NG I YSI SGNE+G F+I STG +T+ A+ LD+E+ + + + A
Sbjct: 3110 TVSARDRDAA-MNGLIKYSISSGNEEGIFAINSSTGILTL--AKALDYELCQKHEMTISA 3166
Query: 2147 ESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG 2203
GG A T +T+ + D NDN+P FL Y + E+ P ++ + A D D G+
Sbjct: 3167 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTN 3226
Query: 2204 GQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATL 2263
I+Y++ +S LF +DP TG ITT LD E L + A + AT+
Sbjct: 3227 AVIAYTVQSSDS--DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATV 3284
Query: 2264 TVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQD 2320
+ + TN+ P + + + +SE A G+ + +V +D D G + Y++ + +
Sbjct: 3285 NIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKK 3344
Query: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD-----GPHEGRANLTVLVEDVNDNAPA 2375
F + + G++ ++G LD E+ +R L++LA + G + V V D ND P
Sbjct: 3345 GFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPI 3403
Query: 2376 FSQSLYQVMLLEHTPPGSAILSVSATDRDSGAN-GHISYHLASPADG--FSVDPNNGTLF 2432
F+ ++Y V + E P G+ + VSA D DS + SY + S + FS++P G
Sbjct: 3404 FTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQ-- 3461
Query: 2433 TIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVT 2492
I T L + ++ + A D G P A++ V L+D ND+ P T+S V
Sbjct: 3462 -ITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM-- 3518
Query: 2493 EDLPPGSTLLTLEATDADGSRSHAAVDYSIIS-GNWGRVFQLEPRLAEAGESAGPGPRAL 2551
E+ PG+ ++TL++TD D + Y ++S G F L
Sbjct: 3519 ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLS---------------TA 3563
Query: 2552 GCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
G L +D E + + L+V D G P SS V +TV+D NDNP
Sbjct: 3564 GVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 808 bits (2087), Expect = 0.0
Identities = 727/2483 (29%), Positives = 1158/2483 (46%), Gaps = 164/2483 (6%)
Query: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVT------VRVADINDHAPAFPQA 146
AID SG V LD E Y D T+ + + + D ND+ P+FP++
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS 1318
Query: 147 RAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPE 206
+ V E+ G A D+D+G Y+++G TF + G
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTG-------S 1371
Query: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266
+ + +LD E +S Y L + A D G PPR + + + + D ND+ P+F + E
Sbjct: 1372 IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVE 1431
Query: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326
++ G+ V+ V A D DA +NG ++Y I ++ G+ F+ID G + +D E
Sbjct: 1432 NIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH-FTIDEVKGTIYTNAEIDREFAN 1490
Query: 327 VHELVVQARDGGAHPEL---GSAFVTVHVRDANDNQPS-MTVIFLSADGSPQVSEAAPPG 382
+ EL V+A D E VT+ V D NDN P ++ L+AD S + G
Sbjct: 1491 LFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVI------G 1544
Query: 383 QLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRV 442
++ I +DPD+G + + G+ + + S V A + YNL V
Sbjct: 1545 SVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALV---PSQLIYNLIV 1601
Query: 443 TATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQ 502
+ATD G P R ++ L + + P F + Y L E G+ V+ + A P +
Sbjct: 1602 SATDLG--PERRKSTTELTIILQGLDGPVFTQPKYITI-LKEGEPIGTNVISIEAASP-R 1657
Query: 503 GTNGQVTYSLAP-----GAHTHWFSIDPTSGIITTAASLDYELEPQPQLI-VVATDGGLP 556
G+ V Y + F+I +GII TAA LD E L+ V A +
Sbjct: 1658 GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTA 1717
Query: 557 -PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSY 615
P A V + LQD+NDN P F + ++ E G+ +Q+TA DAD G L++Y
Sbjct: 1718 FPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTY 1777
Query: 616 SLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFL 675
++ +G S FRID SGD+ TR LDR++ S + V A D G S + + + +
Sbjct: 1778 TIISGADDS----FRIDPESGDLIATRRLDRERR-SKYSLLVRA-DDGLQSSDMRINITV 1831
Query: 676 SDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTL 735
SD ND+ P+F Y+ I + PG+ V + A D D G +G ++Y + + +F L
Sbjct: 1832 SDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFL 1891
Query: 736 DEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQY 795
+ +G+ + L L + AEDGGG + RV +I+ PPIF Y
Sbjct: 1892 NPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFT--TIRVYFNILDVNDNPPIFSLNSY 1949
Query: 796 VFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854
S+ E++ G++V + + G + +T S++ GD G F++D +G+L+ L+ LDR
Sbjct: 1950 STSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDR 2008
Query: 855 ELLGPV-LELEVRAGSGVPPA--FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGT 911
E L ++V +P + + A+V ++L DVNDN P F +P+ T + P NT T
Sbjct: 2009 ESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYI-PENTPIDT 2067
Query: 912 PIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEAR 971
++ +A DPDSG NS + +TLL G F++ G VRL L + L + A
Sbjct: 2068 VVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVAT 2127
Query: 972 DGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD--- 1028
D G P +S + V+V D+ P F Y+V++ T GT ++QV A D
Sbjct: 2128 DKGQPSLSSSTEVVVMVLDINDNN--PIFAQALYKVEINENTLTGTDIIQVFAADGDEGT 2185
Query: 1029 GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGT 1088
G + Y + + F ++ +G + V LDRE Y L V A +T T
Sbjct: 2186 NGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTP---RTDT 2242
Query: 1089 ATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGT---SVGRVFATDRDSGPNGRLTYSLQ 1145
+TV + +L+ N+ P P + V EN GT ++ +V A D D G N +L+Y L
Sbjct: 2243 STVSIVLLDINDFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLF 2300
Query: 1146 QLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLN 1205
+ED+ AF + +GE+ Q+LDRE + + L++ D GSP + TGT++V V D+N
Sbjct: 2301 GGNEDN-AFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVN 2358
Query: 1206 DNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFS 1265
DN PTF A +P+ P GT V + A D D +N I + G G+ F+
Sbjct: 2359 DNVPTF------ASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIG-GNSQFT 2409
Query: 1266 LHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP-PRSASLQLLVQVLPSARLAEPPPDL 1324
++P +G+++T+A L R + +Y L + D GSP P S+S +LV V + + PP
Sbjct: 2410 INPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTD---VNDNPPRF 2466
Query: 1325 AERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGA---LTYTLVGGADPEGTFAL 1381
+P PGS + +V + A +G L Y+L G + F +
Sbjct: 2467 QHHPYVTHIP--------SPTLPGSFVFAVTVTD-ADIGPNSELHYSLSGRNSEK--FHI 2515
Query: 1382 DAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENE-HAPAFARDP 1440
D G + A PL+ G +V + GG+ + V V+ N+ P
Sbjct: 2516 DPLRGAIMAAGPLN---GASEVTFSVHVKD-GGSFPKTDSTTVTVRFVNKADFPKVRAKE 2571
Query: 1441 LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
PEN + + T S G + + L ++D TG +S +
Sbjct: 2572 QTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGN-----TFQIDQLTGQVSISQP 2626
Query: 1501 LDRETTPALLLLVEATDR--PANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPED 1557
LD E ++ +EA D P +S + + V D NDNAP+F P + E+
Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLD-----ITVLDVNDNAPIFKEDPFISEILEN 2681
Query: 1558 QPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHV 1616
P L V A D D G ++ Y + +G + F ++ +TG + VRPLDRE+ + +V
Sbjct: 2682 LSPRKI-LTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYV 2740
Query: 1617 LTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDP 1676
LT+ +SD GSP +S + + +++ D ND AP F Q +S + EN+P G ++ + +D
Sbjct: 2741 LTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDE 2799
Query: 1677 DVGANGQVTYGGV-SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHV 1735
D+G N Y + +S F+++P TG + R L+RE+ + + V A D G
Sbjct: 2800 DIGINAISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVST 2856
Query: 1736 TVRVAVEDENDHAPTFGSAHLSLEVPEGQD-PQTLTMLRASDPDVGANGQLQYRILDGDP 1794
V + V D ND+AP F L+ PE + +T + A+DPD G+NGQ+ Y I
Sbjct: 2857 DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKS--Q 2914
Query: 1795 SGAFVLDLASGEFGTMRPLDREVEPAFQ--------LRIEARDGGQPALSATLLLTVTVL 1846
S F ++ +GE + L + F + + D G+P+L + +T+ ++
Sbjct: 2915 SEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV 2974
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQA-HDPDAGANGHVTYYLGAGT-AGAFLL 1904
D+ND+AP F Y V ++V GT L+++ A D D G N V Y++ G F L
Sbjct: 2975 DSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKL 3034
Query: 1905 EPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSP 1964
+ +G + A++L + ++ +V+A D PLS+ +V ITV + N H P F S
Sbjct: 3035 DNDTGWISVASSLISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEFSQSH 3093
Query: 1965 LRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVA 2023
+ +P S S ++ + T+ A DRDA N I Y ++ G ++S TG + +A
Sbjct: 3094 MSATIPE---SHSIGSI-VRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLA 3149
Query: 2024 RSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP 2083
++ + + I A D G AR+ + V + + P F T+ ENAP
Sbjct: 3150 KALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPS 3209
Query: 2084 GTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRL 2142
GT ++ A A GTN I Y++ S ++ F I P+TG IT + LDFE L
Sbjct: 3210 GTTVIHLNATDADSGTNAVIAYTVQS-SDSDLFVIDPNTGVITTQGF--LDFETKQSYHL 3266
Query: 2143 VLQA---ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199
++A +F + + L+ N+ PRF+ Y + E+ P + +V A D D
Sbjct: 3267 TVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRD 3326
Query: 2200 QGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGS--PAL 2257
G+ G++ Y + + +G F ++ TG I + ILDRE L ++A + GS A
Sbjct: 3327 LGTDGEVHYLIFGNSRKKG-FQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGAD 3385
Query: 2258 VGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLW----YVL 2313
+ T+ V V+D ND + +++SE +G+ + V+ D DS P W Y +
Sbjct: 3386 IDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPS-WSRFSYFI 3444
Query: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVN 2370
FS+ G++++T LD E Y L +LA D G A+L V +ED+N
Sbjct: 3445 GSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDIN 3504
Query: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGAN-GHISYHLAS--PADGFSVDPN 2427
DN P + S +VM E+ PG+ ++++ +TD D N G +Y+L S PA +
Sbjct: 3505 DNGPMLTVSEGEVM--ENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST 3562
Query: 2428 NGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY 2487
G L T T + + + + +D G P ++ TVH+ + DQND+
Sbjct: 3563 AGVLST---TREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEI 3619
Query: 2488 RVAVTEDLPPGSTLLTLEATDAD 2510
V +L PG L +++ D D
Sbjct: 3620 FVNYYGNLFPGGILGSVKPQDPD 3642
Score = 781 bits (2016), Expect = 0.0
Identities = 703/2438 (28%), Positives = 1092/2438 (44%), Gaps = 177/2438 (7%)
Query: 46 SLDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTA 104
+L + + E G L+ ++A +G A L Y I+ G +I ++G + A
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGT---FSISPNTGSIFLA 1375
Query: 105 RVLDREQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
+ LD E + Y+ D +T+ V + V D ND+ P+FP + E+
Sbjct: 1376 KKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPI 1435
Query: 159 GTRYPLEPARDADAGRLGTQGYALSGD-GAGETFRLETRPGPDGTPVPELVVTGELDREN 217
GT A D DA G Y + G F ++ G + E+DRE
Sbjct: 1436 GTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGT-------IYTNAEIDREF 1488
Query: 218 RSHYMLQLEAYDGGSP-PRRAQALLDVTLL--DINDHAPAFNQSRYHAVVSESLAPGSPV 274
+ + L ++A D P R AL +VT+L D+ND+ P F S+ S GS +
Sbjct: 1489 ANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI-SQNALAADPSAVIGSVL 1547
Query: 275 LQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA 334
+ A+D D G NG + YEI ++ F +D ++G L++ L + ++ L+V A
Sbjct: 1548 TTIMAADPDEGANGEIEYEIINGDTD---TFIVDRYSGDLRVASAL-VPSQLIYNLIVSA 1603
Query: 335 RDGGAHPELGSAFVTVHVRDAND---NQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391
D G + +T+ ++ + QP I + E P G V I +
Sbjct: 1604 TDLGPERRKSTTELTIILQGLDGPVFTQPKYITI---------LKEGEPIGTNVISIEAA 1654
Query: 392 DP--DDGDFAHVNVSLEGGEGH----FALSTQDSVIYLVCVARRLDREERDA-YNLRVTA 444
P + + VS+ E F + +I + LDRE+ Y + V A
Sbjct: 1655 SPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI---LDREQGACLYLVDVYA 1711
Query: 445 TDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQG 503
+ + R + A V + + D+NDN P F + + E GS ++++TA D D+G
Sbjct: 1712 IEKSTAFPRTQRAEVEITLQDINDNPPVFPTDML-DLTVEENIGDGSKIMQLTAMDADEG 1770
Query: 504 TNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSAT 563
N VTY++ GA F IDP SG + LD E + L+V A DG +S
Sbjct: 1771 ANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMR 1826
Query: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGS 623
+++ + DVND+ P+F R Y+ +PE T PG+ + ATD DSG G ++Y +
Sbjct: 1827 INITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE---D 1883
Query: 624 SGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
F ++ +G TR LD + + TV A DGGG + + V + D NDNPP
Sbjct: 1884 DEDGIFFLNPITGVFNLTRLLDYEV-QQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPP 1942
Query: 684 QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
F Y+ S+ P G+ VL D D G + +L+Y I +G+S FT+D+ +G+L
Sbjct: 1943 IFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLK 2001
Query: 744 VAWPLARRANSVVQLEIGAEDGGGLQAE---PSARVDISIVPGTPTPPIFEQLQYVFSVP 800
V L R + S L + D + A +A+V I ++ PP F + + +P
Sbjct: 2002 VLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IP 2060
Query: 801 EDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELL 857
E+ T V QA +P P TL G+ FS+ + G ++ LDRE +
Sbjct: 2061 ENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEV 2117
Query: 858 GPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
V G P + V V++ D+NDN+P F V + NT GT I +
Sbjct: 2118 SNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVF 2177
Query: 918 ALDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976
A D D G N +V + ++ G F +D TG + + +PL P + L ++A D GS
Sbjct: 2178 AADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGST 2237
Query: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGT-TAGTQVLQVQAQAPDGGP---I 1032
PRT + +V+ D+ P F Y V++P T +LQV A+ D G +
Sbjct: 2238 PRTDTSTVSIVLLDIND--FVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKL 2295
Query: 1033 TYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092
+Y L + F L SG L V +LDRE +E ++L + A L TGT T+
Sbjct: 2296 SYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPAL---TGTGTIN 2351
Query: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK 1152
V + + N++ P + F + E+ P GT V V A+D D+ N + ++ +
Sbjct: 2352 VIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI-----RIIGGNS 2406
Query: 1153 AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP-PRSTTGTVHVAVLDLNDNSPTF 1211
F I+P TG++ T LDRE + +Y L+V D GSP P S++ +V V V D+NDN P F
Sbjct: 2407 QFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRF 2466
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSG 1271
+P PG+ V + D D G N + Y+L+G SE F + P G
Sbjct: 2467 QHHPYVT------HIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRG 2520
Query: 1272 ELLTAAPLIRAERPHYVLTLSAH--DQGSPPRSASLQLLVQVL-----PSARLAEPPPDL 1324
++ A PL A +T S H D GS P++ S + V+ + P R E
Sbjct: 2521 AIMAAGPLNGASE----VTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMF 2576
Query: 1325 AERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAA 1384
E P + + +T ++ G EP ++Y + G + TF +D
Sbjct: 2577 PENQPVSSLVTTITGSSLRG-------------EP-----MSYYIASG-NLGNTFQIDQL 2617
Query: 1385 SGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALA 1444
+G++ +++PLDFE + +G + ++ + V D N++AP F DP
Sbjct: 2618 TGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISE 2677
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRE 1504
+ EN P L T A D D GPN + Y ++ + ++ TG + + R LDRE
Sbjct: 2678 ILENLSPRKIL-TVSAMDKDS-GPNGQLDYEIVNGNME-NSFSINHATGEIRSVRPLDRE 2734
Query: 1505 TTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAA 1564
+L ++++D+ S ++ V + + DENDNAP F+ +PE+ P G
Sbjct: 2735 KVSHYVLTIKSSDK---GSPSQSTSVKVMINILDENDNAPRFSQIFSAHVPENSPLGYTV 2791
Query: 1565 LHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
V D D+G A Y + F ++ STG + + RPL+RE + + V A D
Sbjct: 2792 TRVTTSDEDIGINAISRYSIMDASLP-FTINPSTGDIVISRPLNREDTDRYRIRVSAHDS 2850
Query: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQV 1684
G + + +T+ V D+ND AP F + Y + E G+ + + ATDPD G+NGQV
Sbjct: 2851 GW---TVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQV 2907
Query: 1685 TYGGVS-SESFSLDPDTGVLTTLRALDREEQ---EEINLT-----VYAQDRGSPPQLTHV 1735
Y S SE F ++ TG + + L + +N+ V + DRG P ++
Sbjct: 2908 FYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISET 2967
Query: 1736 TVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT--LTMLRASDPDVGANGQLQYRILDGD 1793
TV + + D ND+AP F + V + T + + D D G N +++Y I + +
Sbjct: 2968 TVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDN 3027
Query: 1794 PSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAP 1853
G F LD +G L ++ F + + A+D G P LS+ + +TV + N H P
Sbjct: 3028 HLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTP 3087
Query: 1854 AFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELR 1912
F S +PE G+++ + A D DA NG + Y + +G G F + S+G L
Sbjct: 3088 EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILT 3147
Query: 1913 TAAALDREQCPSYTFSVSAVDGAAAGPLSTT--VSVTITVRDVNDHAPTFPTSPLRLRLP 1970
A ALD E C + ++SA+DG G ++ T SVT+ V DVND++P F + +
Sbjct: 3148 LAKALDYELCQKHEMTISAIDG---GWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204
Query: 1971 RPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG 2030
PS +T + L A D D+G NA I Y + + +D TG I
Sbjct: 3205 ENAPSGTT----VIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFET 3260
Query: 2031 PRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSP 2090
+ L + A ++ R + + + L+G E PRF I E AP GT +
Sbjct: 3261 KQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEV 3320
Query: 2091 RAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG 2149
A GT+G + Y I + K F I TG I V LD E R+ L + A++
Sbjct: 3321 FASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLAKNF 3378
Query: 2150 GAFAFT-----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQ-GSG 2203
G+ + +T+ DAND P F Y + E P+ + V A D D S
Sbjct: 3379 GSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSW 3437
Query: 2204 GQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATL 2263
+ SY + + G F ++P TG IT TA LDRE L ++A D G+P+ GSA+L
Sbjct: 3438 SRFSYFIGSGNE-NGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASL 3496
Query: 2264 TVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD----SGPVLWYVLSPSGPQ 2319
V + D NDN P + E V E+ G+ + + D D GP +Y+LS +GP
Sbjct: 3497 LVTLEDINDNGPMLTVS-EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLS-TGPA 3554
Query: 2320 DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG-----PHEGRANLTVLVEDVNDNAP 2374
+ G +S T +D EQ + L ++ D G ++TV+ D NDN
Sbjct: 3555 TSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVI--DQNDNPS 3612
Query: 2375 AFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHIS 2412
V + PG + SV D D + H S
Sbjct: 3613 QSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCS 3650
Score = 502 bits (1292), Expect = e-141
Identities = 476/1669 (28%), Positives = 738/1669 (44%), Gaps = 105/1669 (6%)
Query: 88 VGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPD------GATVEVTVRVADINDHAP 141
+G +I G VR LDRE+ Y T V D ++ EV V V DIND+ P
Sbjct: 2093 LGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNP 2152
Query: 142 AFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDG 201
F QA +++ E+T GT A D D G G Y + + FR+++ G
Sbjct: 2153 IFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGA-- 2210
Query: 202 TPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYH 261
+ V LDRE Y L ++A D GS PR + + + LLDIND P F S Y
Sbjct: 2211 -----ITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYS 2265
Query: 262 AVVSESLAP-GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPL 320
V E+L +LQV A D D G N ++Y + D F++ A +G L + + L
Sbjct: 2266 VNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE--DNAFTLSA-SGELGVTQSL 2322
Query: 321 DFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAP 380
D E + L++ A D G+ G+ + V V D NDN P+ F S + E AP
Sbjct: 2323 DRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT----FASKAYFTTIPEDAP 2378
Query: 381 PGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNL 440
G V ++ SD D A + + GG F ++ I + LDRE +D Y L
Sbjct: 2379 TGTDVLLVNASDADASKNAVIRII--GGNSQFTINPSTGQIITSAL---LDRETKDNYTL 2433
Query: 441 RVTATDSGSP-PLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARD 499
V +D+GSP PL + + ++ VTDVNDN P F Y +P LPGSFV VT D
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTH-IPSPTLPGSFVFAVTVTD 2492
Query: 500 PDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559
D G N ++ YSL+ G ++ F IDP G I A L+ E V DGG P
Sbjct: 2493 ADIGPNSELHYSLS-GRNSEKFHIDPLRGAIMAAGPLNGASEVT--FSVHVKDGGSFPKT 2549
Query: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
S TV+V + D P+ + PE + +T + P +SY + +
Sbjct: 2550 DSTTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEP---MSYYIAS 2605
Query: 620 G-LGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS-- 676
G LG++ F+ID +G V ++ LD ++ + + A DGG Y K+ ++
Sbjct: 2606 GNLGNT----FQIDQLTGQVSISQPLDFEK-IQKYVVWIEARDGGFPPFSSYEKLDITVL 2660
Query: 677 DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD 736
D NDN P F + + I P +L + A D D G +G+L Y I+ GN F+++
Sbjct: 2661 DVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSIN 2719
Query: 737 EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYV 796
+G + PL R S L I + D G S +V I+I+ P F Q+ +
Sbjct: 2720 HATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQI-FS 2778
Query: 797 FSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDREL 856
VPE+ G +V V + + ++ S D F+++ +G + RPL+RE
Sbjct: 2779 AHVPENSPLGYTVTRVTTSDEDIGINAIS-RYSIMDASLPFTINPSTGDIVISRPLNRE- 2836
Query: 857 LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916
+R + V + + D+NDN+P F + P T G+ + +
Sbjct: 2837 --DTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQV 2894
Query: 917 RALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHV---RLMRPLGPSGGP-----AHELEL 968
A DPD G N +V F + F ++ TTG + ++++ +G H +
Sbjct: 2895 FATDPDEGSNGQV-FYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIV 2953
Query: 969 EARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQA-QAP 1027
+ D G P S V + V + AP+F Y + GT++++V A
Sbjct: 2954 TSSDRGKPSLISE--TTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDK 3011
Query: 1028 DGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQ 1084
D G + Y ++ + F L+ +GW+ V ++L + + + + V A L
Sbjct: 3012 DFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSS 3071
Query: 1085 QTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
Q ATV +++ +N H+P S+ + E+ G+ V V A DRD+ NG + YS+
Sbjct: 3072 Q---ATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI 3128
Query: 1145 QQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDL 1204
+E+ F I+ TG +T + LD E +++ + DGG R+ +V V V+D+
Sbjct: 3129 SSGNEEG-IFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDV 3187
Query: 1205 NDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELF 1264
NDNSP FL V + P GT V L A D D G N I YT+ S+LF
Sbjct: 3188 NDNSPVFLSDDYFP------TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLF 3241
Query: 1265 SLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDL 1324
+ P++G + T L + Y LT+ A + R + + +Q+ + E P
Sbjct: 3242 VIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTN---EYVPRF 3298
Query: 1325 AERDPAAPVPVVLTVTAAEGLRPGSLLGSV-AAPEPAGVGALTYTLVGGADPEGTFALDA 1383
+ + +E G+++G V A+ G + L+ G + F ++
Sbjct: 3299 VSK--------LYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK 3350
Query: 1384 ASGRLYLARPLDFEAGPPWRALTVRAEGPG---GAGARLLRVQVQVQDENEHAPAFARDP 1440
+G++Y++ LD E +L V A+ G GA + V V V D N+ P F +
Sbjct: 3351 KTGQIYVSGILDREKEERV-SLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNI 3408
Query: 1441 LALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
++ + E G + A D+D S Y + A ++ +TG ++
Sbjct: 3409 YSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSY-FIGSGNENGAFSINPQTGQITVTAE 3467
Query: 1501 LDRETTPALLLLVEATDRPANASRRRAARVSARVFVT--DENDNAPVFASPSRVRLPEDQ 1558
LDRET P L V A D S +A SA + VT D NDN P+ + S + E++
Sbjct: 3468 LDRETLPIYNLSVLAVD-----SGTPSATGSASLLVTLEDINDNGPML-TVSEGEVMENK 3521
Query: 1559 PPGPAALHVVARDPDL--GEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHV 1616
PG + + + DPDL + Y L++G + S+ G LS R +DREQ A+
Sbjct: 3522 RPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFY 3581
Query: 1617 LTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDP 1676
L+VV D G P S+T + ++V D ND + E V N PG L +++ DP
Sbjct: 3582 LSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDP 3641
Query: 1677 DVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQD 1725
DV + + + FS+ G L + R +LTV + D
Sbjct: 3642 DVLDSFHCSLTSGVTSLFSI---PGGTCDLNSQPRSTDGTFDLTVLSND 3687
Score = 172 bits (435), Expect = 6e-42
Identities = 153/542 (28%), Positives = 237/542 (43%), Gaps = 58/542 (10%)
Query: 2385 LLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDG 2444
+LE PPG+ + ++ +Y L+ F+++ + G L+T T+
Sbjct: 51 VLEEQPPGTLVGTIQTRPG-------FTYRLSESHALFAINSSTGALYT-TSTIDRESLP 102
Query: 2445 SGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
S +++V+ + P V V ++D ND+AP F V ED G ++
Sbjct: 103 SDVINLVVLSSAPTYP-----TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILD 157
Query: 2505 EATDAD-GSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFE 2563
ATD+D GS Y II GN F+L+ L +GE A LV LD E
Sbjct: 158 TATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGA------FLHLVSKGGLDRE 211
Query: 2564 SLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623
QY L V D+G+P + + V VTV D+NDNPPVF + Y+ VPED VG+ +L
Sbjct: 212 VTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQ 271
Query: 2624 VEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPA 2683
V A+DAD G + +R+ + D F++D +G + + LD E + ++ L VQA D
Sbjct: 272 VAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRG 329
Query: 2684 GAHF-ALAPVTIEVQDVNDHGPA-----FPLNLLSTSVAENQPPGTLVTTLHAIDGDA-G 2736
A I++ DVND+ P FP SV EN GT+V L D D+
Sbjct: 330 VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPA 389
Query: 2737 AFGRLRYSLLEAGPGPEGREAFALNSS----TGELRARVPFDYEHTESFRLLVGAAD--- 2789
A G + +L G + F + SS ++ D E S+ L V +D
Sbjct: 390 ANGNISVQIL----GGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYG 445
Query: 2790 ------AGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGG 2843
S+ ++ + V +++ PVF + + E A G + + ATD D G
Sbjct: 446 APPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSG 505
Query: 2844 ADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVI 2903
+ + YS+ + + G + + SG T+G G RE ++ L +
Sbjct: 506 LNANLRYSIVSGN---------GLGWFHISEH---SGLVTTGSSGGLDRELASQIVLNIS 553
Query: 2904 AR 2905
AR
Sbjct: 554 AR 555
Score = 35.8 bits (81), Expect = 0.72
Identities = 36/141 (25%), Positives = 59/141 (41%), Gaps = 27/141 (19%)
Query: 23 LPLLLLLLLLLGAGVPGAWGQAGSL----------------DLQIDEEQPAGTLIGDISA 66
LP+ L +L + +G P A G A L + ++ E + GTL+ + +
Sbjct: 3473 LPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVMENKRPGTLVMTLQS 3532
Query: 67 GLP--AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPD- 123
P P Y++ + +G T +GV+ T R +DREQ + + VT D
Sbjct: 3533 TDPDLPPNQGPFTYYLLS---TGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDS 3589
Query: 124 -----GATVEVTVRVADINDH 139
+T V + V D ND+
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDN 3610
Score = 35.4 bits (80), Expect = 0.94
Identities = 14/32 (43%), Positives = 21/32 (65%)
Query: 3159 GSYNWDYLLSWCPQFQPLASVFTEIARLKDEA 3190
G++NWD LL+W P F VF ++A L ++A
Sbjct: 4926 GTFNWDNLLNWGPGFGHYVDVFKDLASLPEKA 4957
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 922 bits (2383), Expect = 0.0
Identities = 832/2834 (29%), Positives = 1281/2834 (45%), Gaps = 228/2834 (8%)
Query: 150 LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209
L + E T G+ A+D D L + +SG+ A F +E G P
Sbjct: 40 LLISEDTPVGSSVTQLLAQDMDNDPLV---FGVSGEEASRFFAVEPDTGVVWLRQP---- 92
Query: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
LDRE +S + ++ D R +++ + D+ND+AP F+ Y + E+
Sbjct: 93 ---LDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
Query: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
G+P+ V A+D D G G+V Y F+ID+ G++ + R LD+E + ++
Sbjct: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQF----FAIDSARGIVTVIRELDYETTQAYQ 202
Query: 330 LVVQARDGGAHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARI 388
L V A D L + A + + + D D P IF++ S + E +PPG V I
Sbjct: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNIYEHSPPGTTVRII 258
Query: 389 SVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446
+ D D G + ++ G + FAL V+ L + R + + L V T+
Sbjct: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
Query: 447 SGSPPLRAEA----AFVLHVTDVNDNAPAFDRQLYRP--EPLPEVALPGSFVVRVTARDP 500
++A F + V D+NDNAP F+ Y L +V ++V +D
Sbjct: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
Query: 501 DQGTNGQVTYSLAPGAHTHWFSIDPTSG------IITTAASLDYELEPQPQLIVVATDGG 554
+ G N L G ++H F I PTS I A LDYE + + A +
Sbjct: 379 NLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
Query: 555 LPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLS 614
+P A V + L + NDN P F + YN SL E GT L V ATD D+G FG +S
Sbjct: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVS 496
Query: 615 YSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVF 674
Y S F +D +G + LD + F T+ A DGGG ++ V++
Sbjct: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRIN 550
Query: 675 LSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLF- 733
+ D NDN P F Y ++ P T ++RLRA D D + +++Y I++ ++ +
Sbjct: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
Query: 734 --TLDEQSGLLTVAWPL--ARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
+L E G+++V+ PL + +N ++ L + A D G + V I + PP
Sbjct: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
Query: 790 FEQLQYVFSVPEDVAPGTSVGIVQA----HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
F + Y SV E++ G +V + A + + SL G F ++A SG
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGE 727
Query: 846 LQTLRPLDRELLGPVLELEVRA---GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVL 902
+ T LDRE + L VRA G G +A V + L D+NDN P + +
Sbjct: 728 ITTTSLLDRETKSEYI-LIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
Query: 903 LPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGP 962
L T P + + T+ A+DPD G N + ++ + ++++ TTG +R + P
Sbjct: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENP 845
Query: 963 -AHELEL------EARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTA 1015
HE EL D G PP + V V + P F + + ++ G A
Sbjct: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
Query: 1016 GTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKV 1072
G + QV A D G ++Y + F + SG + LDRE Y L+V
Sbjct: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
Query: 1073 MAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR 1132
+A S A ++ T+T+ + +L+ N+ +P ++V+E+ P V + TD
Sbjct: 966 VA---SDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
Query: 1133 DSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRS 1192
D G N L+Y + + D K F + + V T+ LDRE ++Y L+++ D G +
Sbjct: 1023 DVGLNAELSYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKR 1081
Query: 1193 TTG--TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENG 1250
TG TV V VLD+NDN P FLQ+S A VP+ +P G + L+A D DEGE G
Sbjct: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEA------SVPEDIPEGHSILQLKATDADEGEFG 1135
Query: 1251 TILY-TLTGPGSELFSLHPHSGELLTA-APLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308
+ Y L G F +H +G L+ PL R +VL + A++ P +S++++
Sbjct: 1136 RVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI 1195
Query: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYT 1368
V V + + P ++ + L + G+ ++ + G + Y
Sbjct: 1196 VYV---EDINDEAPVFTQQQYSR-----LGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
Query: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQD 1428
++ GA EG F +D ++G + LD+E + + V + + +
Sbjct: 1248 ILSGA--EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLN 1305
Query: 1429 ENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRL 1488
E + A F+ A+ EN G + +A D R+ ++
Sbjct: 1306 ELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKI 1364
Query: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP--VF 1546
DA TG ++ +DRE L V A D + + V + V DENDN+P F
Sbjct: 1365 DAITGVITVQGLVDREKGDFYTLTVVADD----GGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 1547 ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRL---HSSTGALS 1602
S S V +PED P G V A DPD G +V + LASG G F + + S G +
Sbjct: 1421 TSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVF 1480
Query: 1603 VVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQ-EYSVLLREN 1661
V RPLDRE+ ++L VVASD G+PPR +L V++ D+ND P + Y+V + EN
Sbjct: 1481 VARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNEN 1540
Query: 1662 NPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA-LDREEQEEI 1717
GT+++ +RATD D+G N ++Y G +F +D +G + T A DRE Q
Sbjct: 1541 VGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFY 1600
Query: 1718 NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP--QTLTMLRAS 1775
+L +D G+P V V + DEND+AP F H + + EG D +L ++A
Sbjct: 1601 HLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQAL 1660
Query: 1776 DPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPAL 1835
D D G NG + Y I+ G+ F +D G + LD E+ I P L
Sbjct: 1661 DLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
Query: 1836 SATLLLTVTVL----DANDHAPAFPVPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHV 1890
S L T TVL D ND+ P FP EV E P G + AHD D+G NG V
Sbjct: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQV 1779
Query: 1891 TYYLGAG-TAGAFLLEPSSGELRTA--AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVT 1947
Y + G G F++ P G LR LDRE Y ++ A D PLS+T+ V
Sbjct: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD-RGMPPLSSTMLVG 1838
Query: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGT 2006
I V D+ND+ P P+ + + P S +A + A D D+G NA + + + AG
Sbjct: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSS----FVAHVLASDADSGCNARLTFNITAGN 1894
Query: 2007 PPPGTTVDSYTGEIRVARSPVALGPRDRV----LFIVATD---LGRPARSATGVIIVGLQ 2059
+++ TG + V R P+ R+R+ L I D R AR ++++ L
Sbjct: 1895 RERAFFINATTGIVTVNR-PL---DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
Query: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPI-------------TYSI 2106
E + P F +++ +A + EN+P GTP+ NGPI TY +
Sbjct: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV--------LNGPILALDADQDIYAVVTYQL 2002
Query: 2107 LSGNEKGTFSIQPSTGAITVRSAEGLDFEV--SPRLRLVLQAESGGAFAFTV-LTLTLQD 2163
L G + G F I STG +TVRS +D E P L L+L AE G T L +T+ D
Sbjct: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061
Query: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVD 2223
NDN P F L E+ P +LQV A D D G G++ Y + A R L H+
Sbjct: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHL- 2120
Query: 2224 PTTGTITT-TAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWE 2282
TG I A +DRE RL ++ATDRG+ L G+A +T+++ D ND+RP P +
Sbjct: 2121 -VTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
Query: 2283 -LRVSEDALLGSEIAQVTGNDVDSGPVLWYVL-----------SPSGPQDPFSVGRYGGR 2330
+ V E A G+ IA +T D D P L Y + +D F+V G
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
Query: 2331 VSLTGPLDFEQCDRYQLQLLAHDGPHE--------GRANLTVLVEDVNDNAPAFSQ---S 2379
V + P++ E Y++ L D + A LTV V DVNDN P F +
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
Query: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVA 2439
Y +LE PG+ +++V+A D D G NG ++Y L V + + ++
Sbjct: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
Query: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
+ ++ ++ + A D+G+P RAA V++++ D ND+ P F Y+ AV ED+P G+
Sbjct: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
Query: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559
+LT+ ATDAD S + A ++YS+ G+ F + P G + +L
Sbjct: 2420 IILTVTATDAD-SGNFALIEYSL--GDGESKFAINP--------------TTGDIYVLSS 2462
Query: 2560 LDFESLTQYNLTVAAADR----GQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615
LD E Y LT A D + + V V + VLDVND P F++ + +V E+
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
Query: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675
P G ++ + A+D D GP+G + +++ G F +D SG + L ++ + L
Sbjct: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
Query: 2676 VVQAADPAGAH-FALAPVTIEVQDVNDHGPAF--PLNLLSTSVAENQPPGTLVTTLHAID 2732
V A D + + +EV DVND+ P F P N + E P + V ++A D
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 2733 GDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN 2792
D G G +RYS L+ G E F ++ +G ++ D E + L++ A+D G
Sbjct: 2640 KDEGLNGAVRYSFLKTA-GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
Query: 2793 ---LSASVTVSVLVTGEDEYDPVFLAP---AFHFQ---VPEGARRGHSLGHVQ-ATDEDG 2842
+ V + D+ +P+F+ P + +Q VPE + RG +G+V A D D
Sbjct: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
Query: 2843 GADGLVLYSLATSS 2856
G + +V Y +A +
Sbjct: 2759 GPNAIVYYFIAAGN 2772
Score = 831 bits (2147), Expect = 0.0
Identities = 838/2969 (28%), Positives = 1298/2969 (43%), Gaps = 254/2969 (8%)
Query: 37 VPGAWGQAGSLD----------LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGS 86
+ G WGQ L L I E+ P G+ + + A PL++ +S +E S
Sbjct: 18 ISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEAS 75
Query: 87 GVGTDLAIDEHSGVVRTARVLDREQRDRY--RFTAVTPDGA-TVEVTVRVADINDHAPAF 143
A++ +GVV + LDRE + + F+ G T +V ++V D+ND+AP F
Sbjct: 76 RF---FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
Query: 144 PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTP 203
++++PE+T GT + A D D G G+ Y S + F +++ G
Sbjct: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQFFAIDSARG----- 185
Query: 204 VPELVVTGELDRENRSHYMLQLEAYD-GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 262
+ V ELD E Y L + A D + P A L + + D+ D P F Y
Sbjct: 186 --IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 243
Query: 263 VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDF 322
+ E PG+ V + A D D G + Y I + F++D +G+L L LD
Sbjct: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNTNSIFALDYISGVLTLNGLLDR 301
Query: 323 EQRRVHE---LVVQARDGGAHPELGSAFVT----VHVRDANDNQPSMTVIFLSADGSPQV 375
E L V+ + A VT + V D NDN P F S++ S +
Sbjct: 302 ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE----FNSSEYSVAI 357
Query: 376 SEAAPPG-QLVARISVSDPDD--GDFAHVNVSLEGGEGHFAL----STQDSVIYLVCVAR 428
+E A G L I V D D+ G + V L G H + S Q + VA
Sbjct: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAI 417
Query: 429 RLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP 488
LD E D Y+ + A +S P A + + + NDN P F + LY L E
Sbjct: 418 PLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNIS-LYENVTV 475
Query: 489 GSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIV 548
G+ V+ V A D D GT G+V+Y + FS+D +G+I A LDYEL + L +
Sbjct: 476 GTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTI 533
Query: 549 VATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG 608
+A DGG ++ V + + DVNDN P FQ+ Y +L E T +++ ATD DS
Sbjct: 534 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 591
Query: 609 PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF-TVTAVDGGG--L 665
P ++YS+ + + G + +R LD +Q + + TV A+D G L
Sbjct: 592 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 651
Query: 666 KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHIL 725
S V V + + DENDNPP F Y S+ G VL L A D D+ I
Sbjct: 652 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIY 711
Query: 726 AGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDG--GGLQAEPSARVDISIVPG 783
+ F ++ +SG +T L R S L + A DG G Q A V+I+++
Sbjct: 712 SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771
Query: 784 TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAV 842
P ++ Y ++ E P + V V A +P G + S+ P +SL++
Sbjct: 772 NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
Query: 843 SGLLQTLR---------PLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPA 893
+G ++T P + EL+ ++ G A + A V V L D+NDN P
Sbjct: 830 TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
Query: 894 FPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRL 952
F + G IY + A+D D G+N V++ + G F ++ ++G V
Sbjct: 890 FQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVT 949
Query: 953 MRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSG 1012
L ++L + A D G+P ++S L + V DV P F Y V +
Sbjct: 950 TTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE--TPTFFPAVYNVSVSED 1007
Query: 1013 TTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069
+V+ + D G ++Y + F + + + LDRE Y+
Sbjct: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
Query: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFA 1129
L + A+ + TGTATV V++L+ N++ P + +V E+ P G S+ ++ A
Sbjct: 1068 LILEAIDNGPVG-KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
Query: 1130 TDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTT-LQTLDREQQSSYQLLVQVQDGGS 1188
TD D G GR+ Y + FRIH G + + LDRE+ SS+ L+V+ +
Sbjct: 1127 TDADEGEFGRVWYRILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
Query: 1189 PPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE 1248
P ++ V V V D+ND +P F Q + G + + GT V +QA D D G+
Sbjct: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLG-----LRETAGIGTSVIVVQATDRDSGD 1240
Query: 1249 NGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308
G + Y + F + +G ++T L + Y++ +SA DQ P +
Sbjct: 1241 GGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVY 1300
Query: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTY- 1367
+ +L + + A+ +L E L G+ + V A + +TY
Sbjct: 1301 ITLLNEL------DEAVQFSNASYEAAIL-----ENLALGTEIVRVQAYSIDNLNQITYR 1349
Query: 1368 -TLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQV 1426
+ F +DA +G + + +D E G + LTV A+ G ++V + V
Sbjct: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKG-DFYTLTVVADDGGPKVDSTVKVYITV 1408
Query: 1427 QDENEHAPAF-ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE--PPV 1483
DEN+++P F A+++PE+ G + T +A D D G N V + L
Sbjct: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDA-GSNGQVVFSLASGNIAGAF 1467
Query: 1484 PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNA 1543
+ + G + R LDRE +L V A+DR + R +V + D NDN
Sbjct: 1468 EIVTTNDSIGEVFVARPLDREELDHYILQVVASDR---GTPPRKKDHILQVTILDINDNP 1524
Query: 1544 PVFASP--SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGA 1600
PV SP V + E+ G A + V A D D+G + +SY + G D FR+ +G
Sbjct: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
Query: 1601 LSV-VRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659
++ P DRE+++ + L D G+P SAT + V++ D ND AP FQQ Y VLL
Sbjct: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD 1644
Query: 1660 EN-NPPGTSLLTLRATDPDVGANGQVTYGGVSS---ESFSLDPDTGVLTTLRALDRE-EQ 1714
E + TSL+T++A D D G NG VTY V+ +F +D GV+T + LD E
Sbjct: 1645 EGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISH 1704
Query: 1715 EEINLTVYAQDRGSPPQLTH-----VTVRVAVEDENDHAPTFGSAHLS-LEVPEGQDPQT 1768
L V A D+ P L+H TV V V D ND+ PTF + EV EGQ
Sbjct: 1705 GRYTLIVTATDQ--CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
Query: 1769 LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR--PLDREVEPAFQLRIE 1826
+ A D D G NGQ++Y I+DGDP G FV+ G + LDRE + L I
Sbjct: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1822
Query: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA 1886
ARD G P LS+T+L+ + VLD ND+ P ++ + E+ P + + + A D D+G
Sbjct: 1823 ARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
Query: 1887 NGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT-- 1943
N +T+ + AG AF + ++G + LDRE+ P Y ++S D ++
Sbjct: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
Query: 1944 VSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003
+ I + D ND+ P F S + + P+ + T+ + A D D A + Y+L
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
Query: 2004 AGTPPPGTTVDSYTGEIRVARSPV----ALGPRDRVLFIVATDLGRPARSATGVIIVGLQ 2059
G ++S TG + V + A P L ++A D+G ++T +++ +
Sbjct: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITIL 2060
Query: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQ 2118
+ + P F A+ + EN PPG ++ A G NG + Y I +G + F I
Sbjct: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIH 2119
Query: 2119 PSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPH 2175
TG I V +A +D E RL + A G + ++T+ + D ND+ P FL P
Sbjct: 2120 LVTGVIRVGNAT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISY---SLAASQPARGL-------FHVDPT 2225
+ ES + + A +D ++ Y + A L F V+
Sbjct: 2179 QTVSVLESAEPGTVIANITA--IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236
Query: 2226 TGTITTTAILDREIWAETRLVLMATDRGS-----PALVGSATLTVMVIDTNDNRPTIPQP 2280
TG++ + ++RE+ A + L D S V +A LTV V+D NDN P +P
Sbjct: 2237 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF-KP 2295
Query: 2281 WEL-----RVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVS 2332
+ + R+ E A G+ + V D D +G V + +L P G+V
Sbjct: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
Query: 2333 LTGPLDFEQCDRYQLQLLAHD-GPHEGRANLTVLVE--DVNDNAPAFSQSLYQVMLLEHT 2389
+D+E+ + A D G A + V +E D+NDN P F Q YQ + E
Sbjct: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
Query: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVG----------TVA 2439
P G+ IL+V+ATD DSG I Y L F+++P G ++ + A
Sbjct: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
Query: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
L D G DV R++ V +Q+ D ND P F+ + +V E+ P G+
Sbjct: 2476 LAKDNPG--DVASNRRENS-------VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
Query: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRAL------GC 2553
+++T+ ATD D + + YS+ GPG A G
Sbjct: 2527 SVITMMATDQD-EGPNGELTYSL---------------------EGPGVEAFHVDMDSGL 2564
Query: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA--SYRVTV 2611
+ PL +S +++LTV A D G+PP + V V+DVNDN PVF R + +
Sbjct: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622
Query: 2612 PEDTPVGAELLHVEASDADPGPHGLVRFT---VSSGDPSGLFELDESSGTLRLAHALDCE 2668
E+ P+ + + V A+D D G +G VR++ + F +D SG ++ A LD E
Sbjct: 2623 REEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRE 2682
Query: 2669 TQARHQLVVQAAD--PAGAHFALAPVTIEVQDVNDHGPAF-------PLNLLSTSVAENQ 2719
+QA + L++ A+D + + P+ + ++D++D+ P F P L T V E+
Sbjct: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT-VPEHS 2741
Query: 2720 PPGTLV-TTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHT 2778
P GTLV A+D D G + Y + AG + F L G L D E
Sbjct: 2742 PRGTLVGNVTGAVDADEGP-NAIVYYFIAAG---NEEKNFHLQPD-GCLLVLRDLDRERE 2796
Query: 2779 ESFRLLV------------GAADAGNLSASVT---VSVLVTGEDEYDPVFLAPAFHFQVP 2823
F +V G + +L A +T V V++ ++ P F + V
Sbjct: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
Query: 2824 EGARRGHSLGHVQATDEDGGADGLVLYSL 2852
A+ G L V A D D G + LV YS+
Sbjct: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSI 2885
Score = 816 bits (2107), Expect = 0.0
Identities = 810/2783 (29%), Positives = 1226/2783 (44%), Gaps = 285/2783 (10%)
Query: 51 IDEEQPAGTLIGDISA-----GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
I E P GT + I+A G P G ++ + A+D SGV+
Sbjct: 245 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-------SGNTNSIFALDYISGVLTLNG 297
Query: 106 VLDREQRDRYRFTAV------------TPDGATVEVT--VRVADINDHAPAFPQARAALQ 151
+LDRE Y + TP ATV T + V DIND+AP F + ++
Sbjct: 298 LLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVA 356
Query: 152 VPEHTAFGTRYPL---EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELV 208
+ E G PL +D + G L G+ + T G +
Sbjct: 357 ITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT--SVQGKADIRIR 414
Query: 209 VTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESL 268
V LD E Y L A + P A + +TL++ ND+ P F+Q Y+ + E++
Sbjct: 415 VAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV 473
Query: 269 APGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVH 328
G+ VL V A+D DAG G V+Y S+ FS+D TGL+ L LD+E +
Sbjct: 474 TVGTSVLTVLATDNDAGTFGEVSYFF----SDDPDRFSLDKDTGLIMLIARLDYELIQRF 529
Query: 329 ELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM---TVIFLSADGSPQVSEAAPPGQLV 385
L + ARDGG G V ++V D NDN P+ + + P V++ +
Sbjct: 530 TLTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ-------L 580
Query: 386 ARISVSD---PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREE--RDAYNL 440
R+ +D P + + VS +F +S + ++ V+R LD E+ L
Sbjct: 581 VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY-GVISVSRPLDYEQISNGLIYL 639
Query: 441 RVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDP 500
V A D+G+PPL + + V D NDN P F + Y + + + G+ V+ + A D
Sbjct: 640 TVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI-MAGATVLFLNATDL 698
Query: 501 DQGTN-GQ--VTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPP 557
D+ GQ + YSL F I+ SG ITT + LD E + + LIV A DGG+
Sbjct: 699 DRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGH 755
Query: 558 LASS--ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSY 615
+ ATV++ L D+NDN P ++ Y +L E T P + V A D D G G L Y
Sbjct: 756 NQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 616 SLGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQGPSSFD------FTVTAVDGGG-- 664
S+ PP + +++ +G + TT + + P + V+ D G
Sbjct: 816 SI--------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
Query: 665 LKSMVYVKVFLS--DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSY 722
LK+ VF++ D NDN P F + A + P G ++ ++ A D D+G +G +SY
Sbjct: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
Query: 723 HILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVP 782
+ G F ++ SG++ L R + QL + A D G ++ + I ++
Sbjct: 928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987
Query: 783 GTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSLDA 841
P F Y SV EDV V + N G A ++ ++GG+ G FS+
Sbjct: 988 VNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGY 1047
Query: 842 VSGLLQTLRPLDRELLGP-VLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPED 899
+++T+ LDRE +L LE V A V V + DVNDN P F
Sbjct: 1048 RDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSY 1107
Query: 900 TVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHV-RLMRPLG 957
+P + G I L+A D D G RV + +L G G F + + G + R RPL
Sbjct: 1108 EASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLD 1167
Query: 958 PSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTY-RVDLPSGTTAG 1016
+H L +EA + P S R+ V V+D+ AP F Y R+ L G
Sbjct: 1168 RERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE--APVFTQQQYSRLGLRETAGIG 1225
Query: 1017 TQVLQVQA---QAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVM 1073
T V+ VQA + DGG + Y + + GA F ++ +G + LD E + Y++ V
Sbjct: 1226 TSVIVVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVS 1284
Query: 1074 AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD 1133
A + G +V +++LN+ + + + S A+ EN GT + RV A D
Sbjct: 1285 ATDQAPPF---NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID 1341
Query: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
+ ++ ++ F+I TG +T +DRE+ Y L V DGG P +
Sbjct: 1342 NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDS 1400
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
T V++ VLD NDNSP F S +A + +P+ P G V T++A DPD G NG ++
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSA-----VSIPEDCPVGQRVATVKAWDPDAGSNGQVV 1455
Query: 1254 YTLTGPGS----ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLV 1309
++L E+ + + GE+ A PL R E HY+L + A D+G+PPR L V
Sbjct: 1456 FSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1515
Query: 1310 QVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-PAGVGALTYT 1368
+L D+ + P P V+ E + G+ + V A + G+ ++
Sbjct: 1516 TIL----------DINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSY 1565
Query: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWR--------ALTVRAEGPGGAGARLL 1420
+ + + F +D SG + RP PP R TV EG A
Sbjct: 1566 YITEGNKDMAFRMDRISGEI-ATRP-----APPDRERQSFYHLVATVEDEGTPTLSATT- 1618
Query: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEP-GAALYTFRASDADGPGPNSDVRYRLLRQ 1479
V V + DEN++AP F + + L E P+ +L T +A D D GPN V Y ++
Sbjct: 1619 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-EGPNGTVTYAIVAG 1677
Query: 1480 EPPVPALRLDARTGALSAPRGLDRETTPA-LLLLVEATDRPANASRRRAARVSARVFVTD 1538
V R+D G ++A + LD E + L+V ATD+ S R + + V V D
Sbjct: 1678 NI-VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVND 1736
Query: 1539 ENDNAPVFASPSR--VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLH 1595
NDN P F + E QP GP +A D D G +V Y + G G F +
Sbjct: 1737 INDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
Query: 1596 SSTGALSVVRP--LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQE 1653
G L V + LDRE A + LT+ A D G PP S+T ++ + V D+ND P
Sbjct: 1796 PVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLP 1855
Query: 1654 YSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALD 1710
++ + EN+P + + + A+D D G N ++T+ G +F ++ TG++T R LD
Sbjct: 1856 MNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLD 1915
Query: 1711 REEQEEINLTVYAQDRGSPPQLT---HVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ 1767
RE E LT+ +D P++ + + + + DEND+ P F + EV E
Sbjct: 1916 RERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAG 1975
Query: 1768 T-LTMLR----ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRP---LDREV-- 1817
T LT+L A D D + Y++L G SG F ++ ++G T+R +DRE
Sbjct: 1976 TPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVV-TVRSGVIIDREAFS 2033
Query: 1818 EPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQL 1877
P +L + A D G L++T L +T+LD ND+ P F +V + E+ P G +LQ+
Sbjct: 2034 PPILELLLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
Query: 1878 QAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTA-AALDREQCPSYTFSVSAVDGAA 1936
A D D+G NG + Y + AG FL+ +G +R A +DRE+ SY +V A D
Sbjct: 2092 TATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGT 2151
Query: 1937 AGPLSTTVSVTITVRDVNDHAPTFPTSPLR----LRLPRPGPSFSTPTLALATLRAEDRD 1992
PLS T VTI + D+ND P F +P++ L PG +A + A D D
Sbjct: 2152 V-PLSGTAIVTILIDDINDSRPEF-LNPIQTVSVLESAEPGT-------VIANITAIDHD 2202
Query: 1993 AGANASILYRLAGTPPPGTT------------VDSYTGEIRVARSPV---ALGPRDRVLF 2037
N + Y + G T V+ TG + V +SP+ + + L
Sbjct: 2203 L--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV-KSPMNRELVATYEVTLS 2259
Query: 2038 IVATDLGRPARSAT---GVIIVGLQGEAERGPRFPRASSE---ATIRENAPPGTPIVSPR 2091
++ P RS + + V + + P+F I E A PGT +++
Sbjct: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
Query: 2092 AVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG 2150
AV G NG +TY++L G ++ S+ + + +D+E L ++A G
Sbjct: 2320 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT-VDYEEVHWLNFTVRASDNG 2378
Query: 2151 A---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQIS 2207
+ A + L + D NDN P F +P Y + E P+ +L V A D D G+ I
Sbjct: 2379 SPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIE 2438
Query: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS------A 2261
YSL + F ++PTTG I + LDRE + +L A + +P V S
Sbjct: 2439 YSLGDGESK---FAINPTTGDIYVLSSLDRE--KKDHYILTALAKDNPGDVASNRRENSV 2493
Query: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQ- 2319
+ + V+D ND RP +P + V E+ G+ + + D D GP S GP
Sbjct: 2494 QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGV 2553
Query: 2320 DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAF 2376
+ F V G V+ PL + +++ L ++A DG P G L V V DVNDN P F
Sbjct: 2554 EAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2611
Query: 2377 SQSLYQVML--LEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDPNNG 2429
+ +L E P S + V ATD+D G NG + Y A F +DP +G
Sbjct: 2612 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2671
Query: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAP-GRAARATVHVQLQDQNDHAPSFTLS--- 2485
+ T L + ++L A D G P + V L+D +D+ P F
Sbjct: 2672 LIQT---AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
Query: 2486 --HYRVAVTEDLPPGSTLL--TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAG 2541
Y++ + P TL+ A DAD +A V Y I +GN + F L+P
Sbjct: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEG-PNAIVYYFIAAGNEEKNFHLQPD----- 2782
Query: 2542 ESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD-------RGQPPQSSVVP------V 2588
GCL++L LD E ++ V A+ RG P +V V
Sbjct: 2783 ----------GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEV 2832
Query: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV------- 2641
V + D+ND PP FT+A Y V D VG+EL+ V A DAD G + LV +++
Sbjct: 2833 RVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFR 2892
Query: 2642 ----SSGDPSGLFELDESSGTLR 2660
S D +F + G LR
Sbjct: 2893 ALANDSEDVGQVFTMGSMDGILR 2915
Score = 796 bits (2057), Expect = 0.0
Identities = 739/2516 (29%), Positives = 1151/2516 (45%), Gaps = 209/2516 (8%)
Query: 472 FDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIIT 531
FD L E P GS V ++ A+D D N + + ++ + +F+++P +G++
Sbjct: 36 FDTYLLISEDTPV----GSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVW 88
Query: 532 TAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGT 591
LD E + + + +D + V++ + DVNDN P F Y+ +PE T
Sbjct: 89 LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
Query: 592 QPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQ 648
GT V ATD D G G + YS PP F ID+ G V R LD +
Sbjct: 146 PVGTPIFIVNATDPDLGAGGSVLYSF--------QPPSQFFAIDSARGIVTVIRELDYET 197
Query: 649 GPSSFDFTVTAVDGGG---LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705
++ TV A D L ++ + + ++D D P F Y+ +I SPPGT V
Sbjct: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
Query: 706 RLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARR----ANSVVQLEIG 761
+ A D D+G + Y I++GN+ +F LD SG+LT+ L R ++ + G
Sbjct: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKG 316
Query: 762 AE---DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTS----VGIVQA 814
E D A + +I ++ P F +Y ++ E G + + +V
Sbjct: 317 TELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDK 376
Query: 815 HNPPGRLAPVTLSLSGGDPRG-LFSLDAVSG----LLQTLRPLDRELLGPVLELEVRAGS 869
G + + L G + + S +V G ++ PLD E + + ++ A
Sbjct: 377 DENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
Query: 870 GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRV 929
VP A+V++ L + NDN P F P + L N GT + T+ A D D+G V
Sbjct: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
Query: 930 TFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQ 989
++ + F++D TG + L+ L L + ARDGG T R+R+ V
Sbjct: 496 SY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVL 552
Query: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGA-SSPF 1045
DV P F Y L + TQ+++++A D P ITY + + A S F
Sbjct: 553 DVNDN--VPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
Query: 1046 GLEPQSGW--LWVRAALDRE--AQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101
+ G+ + V LD E + L L VMA+ L T V + + ++N++
Sbjct: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL---NSTVPVTIEVFDENDN 667
Query: 1102 SPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGR--LTYSLQQLSEDSKAFRIHP 1158
P S+ F++V EN G +V + ATD D S G+ + YSL E S FRI+
Sbjct: 668 PPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL----EGSTQFRINA 723
Query: 1159 QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG--TVHVAVLDLNDNSPTFLQASG 1216
++GE+TT LDRE +S Y L+V+ DGG TG TV++ +LD+NDN PT+ A
Sbjct: 724 RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP- 782
Query: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTA 1276
I + + PP + VTT+ A DPD GENGT++Y++ P ++ +SL+ +G++ T
Sbjct: 783 -----YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-PPNKFYSLNSTTGKIRTT 836
Query: 1277 APLIRAERPH-------YVLTLSAHDQGSPPRSA--SLQLLVQVLPSARLAEPPPDLAER 1327
++ E P + +S D G PP A S + V +L DL +
Sbjct: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLL----------DLNDN 886
Query: 1328 DPA-APVPVVLTVTAAEGLRPG-SLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAAS 1385
DP +P V V EG+ G S+ VA G+ L + P F ++++S
Sbjct: 887 DPTFQNLPFVAEV--LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS 944
Query: 1386 GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALAL 1445
G + LD E ++ V ++ + + + V D N+ P F +++
Sbjct: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 1446 PENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET 1505
E+ + +D D G N+++ Y + + R + GLDRET
Sbjct: 1005 SEDVPREFRVVWLNCTDND-VGLNAELSYFITGGNVD-GKFSVGYRDAVVRTVVGLDRET 1062
Query: 1506 TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAA 1564
T A +L++EA D +R + V V D NDN P+F S +PED P G +
Sbjct: 1063 TAAYMLILEAIDN-GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
Query: 1565 LHVVARDPDLGEAARVSYRLASGGDG-HFRLHSSTGAL-SVVRPLDREQRAEHVLTVVAS 1622
L + A D D GE RV YR+ G G +FR+H S G L RPLDRE+ + HVL V A
Sbjct: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
Query: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL-LRENNPPGTSLLTLRATDPDVGAN 1681
+H P ++ + V V D+NDEAP F QQ+YS L LRE GTS++ ++ATD D G
Sbjct: 1182 NHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
Query: 1682 GQVTYGGVSSE--SFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV 1739
G V Y +S F +D TG++ T+ LD E + + V A D+ P +V +
Sbjct: 1242 GLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
Query: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRI---LDGDPSG 1796
+ +E D A F +A + E T ++R + Q+ YR
Sbjct: 1302 TLLNELDEAVQFSNASYEAAILENLALGT-EIVRVQAYSIDNLNQITYRFNAYTSTQAKA 1360
Query: 1797 AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
F +D +G +DRE + L + A DGG P + +T+ + +TVLD ND++P F
Sbjct: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFD 1419
Query: 1857 VPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLL---EPSSGEL 1911
+ S V +PED P G + ++A DPDAG+NG V + L +G AGAF + S GE+
Sbjct: 1420 FTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEV 1479
Query: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
A LDRE+ Y V A D P + +T+ D+ND+ P SP +
Sbjct: 1480 FVARPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVI-ESPFGYNV-S 1536
Query: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARSPVALG 2030
+ T A+ +RA DRD G N+ + Y + G +D +GEI +P
Sbjct: 1537 VNENVGGGT-AVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP---P 1592
Query: 2031 PRDRVLF--IVAT--DLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GT 2085
R+R F +VAT D G P SAT + V + E + P F + E + E T
Sbjct: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
Query: 2086 PIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVS-PRLRLV 2143
+++ +A+ G NG +TY+I++GN TF I G IT +A+ LD+E+S R L+
Sbjct: 1653 SLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT--AAKELDYEISHGRYTLI 1710
Query: 2144 LQAE------SGGAFAFTVLTLTLQDANDNAPRFLRPHYVAF-LPESRPLEGP-LLQVEA 2195
+ A S + T + + + D NDN P F R + F + E +P GP + A
Sbjct: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP--GPRVWTFLA 1768
Query: 2196 DDLDQGSGGQISYSLAASQPARGLFHVDPTTGT--ITTTAILDREIWAETRLVLMATDRG 2253
D D G GQ+ YS+ P G F + P G + LDRE A L + A DRG
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
Query: 2254 SPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG--PVLW 2310
P L + + + V+D NDN P + P + +SE++ + S +A V +D DSG L
Sbjct: 1828 MPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
Query: 2311 YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN------LTV 2364
+ ++ + F + G V++ PLD E+ Y+L + D P R L +
Sbjct: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLI 1947
Query: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL----SVSATDRDSGANGHISYHLASPAD 2420
+ D NDN P F++S YQ ++E++P G+ + + A D D ++Y L
Sbjct: 1948 FLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS 2007
Query: 2421 G-FSVDPNNGTLFTIVGTVALGHDGSG--AVDVVLEARDHGAPGRAARATVHVQLQDQND 2477
G F ++ + G + T+ V + + ++++L A D G A + + + D ND
Sbjct: 2008 GLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDND 2064
Query: 2478 HAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPR 2536
+ P+F+ + V + E+ PPG ++L + ATD D + V Y I +G R + L
Sbjct: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAGAQDRFLIHLVTG 2123
Query: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596
+ G + +D E Y LTV A DRG P S VT+ + D+N
Sbjct: 2124 VIRVGNAT---------------IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
Query: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGP---HGLVRFTVSSGDPSGL---- 2649
D+ P F V+V E G + ++ A D D P + +V V+ D L
Sbjct: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGI-VAKDDTDRLVPNQ 2227
Query: 2650 ---FELDESSGTLRLAHALDCETQARHQLVVQAADPA------GAHFALAPVTIEVQDVN 2700
F ++ ++G++ + ++ E A +++ + D A A +T+ V DVN
Sbjct: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2287
Query: 2701 DHGPAFP---LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGRE 2756
D+ P F + + E PGT + + A+D D G G + Y+LL+ PG E
Sbjct: 2288 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFL 2814
+SS G++ A DYE V A+D G+ +A + V + + ++ +P+F
Sbjct: 2348 ----DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
Query: 2815 APAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
P++ V E G + V ATD D G L+ YSL F IN TTG +Y+
Sbjct: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459
Score = 789 bits (2037), Expect = 0.0
Identities = 801/2917 (27%), Positives = 1266/2917 (43%), Gaps = 257/2917 (8%)
Query: 49 LQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
++I E P GT I ++A P G ++Y S Q S AID G+V R L
Sbjct: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQF---FAIDSARGIVTVIREL 193
Query: 108 DREQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
D E Y+ T D + + + D+ D P F + + EH+ GT
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
Query: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR-- 218
+ A D D GR GY + F L+ G L + G LDREN
Sbjct: 254 TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV-------LTLNGLLDRENPLY 306
Query: 219 SH-YMLQLEAYDGGSPPRRAQALLDVT----LLDINDHAPAFNQSRYHAVVSESLAPGSP 273
SH ++L ++ + + A + T ++DIND+AP FN S Y ++E G
Sbjct: 307 SHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFA 366
Query: 274 V---LQVFASDADAGVNGAVTYEINRRQSEGD--GPFSIDAHTGL-LQLERPLDFEQRRV 327
+ +QV D + G+N + S P S+ + +++ PLD+E
Sbjct: 367 LPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
Query: 328 HELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVAR 387
++ + A + +G A V + + + NDN+P IF + + E G V
Sbjct: 427 YDFDLFANES-VPDHVGYAKVKITLINENDNRP----IFSQPLYNISLYENVTVGTSVLT 481
Query: 388 ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDS 447
+ +D D G F V+ F+L +I L+ RLD E + L + A D
Sbjct: 482 VLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIA---RLDYELIQRFTLTIIARDG 538
Query: 448 GSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507
G ++V DVNDN P F + Y L E + +VR+ A D D N Q
Sbjct: 539 GGEETTGRVR--INVLDVNDNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQ 595
Query: 508 VTYSL-APGAHTHWFSIDPTSG--IITTAASLDYELEPQP--QLIVVATDGGLPPLASSA 562
+TYS+ + A +F I G +I+ + LDYE L V+A D G PPL S+
Sbjct: 596 ITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTV 655
Query: 563 TVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDAD-SGPFGLLS--YSLGA 619
V++ + D NDN P F + Y S+ E G L + ATD D S +G S YSL
Sbjct: 656 PVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-- 713
Query: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG----GLKSMVYVKVFL 675
GS FRI+A SG++ TT LDR+ S + V AVDGG + V + L
Sbjct: 714 ----EGSTQFRINARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITL 768
Query: 676 SDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTL 735
D NDN P + Y ++ +PP + V + A DPD G +G L Y I N ++L
Sbjct: 769 LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSL 826
Query: 736 DEQSGLLTVAWPLARRANS-------VVQLEIGAEDGGG--LQAEPSARVDISIVPGTPT 786
+ +G + + R N + ++ + D G L+A SA V ++++
Sbjct: 827 NSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDN 886
Query: 787 PPIFEQLQYVFSVPEDVAPGTSV-GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
P F+ L +V V E + G S+ +V G V+ + G PR F +++ SG+
Sbjct: 887 DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV 946
Query: 846 LQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPP 905
+ T LDRE + V + +G P + + + + + DVND +P F V +
Sbjct: 947 VVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSE 1006
Query: 906 NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAH 964
+ + L D D G+N+ +++ + G G F+V VR + L A+
Sbjct: 1007 DVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAY 1066
Query: 965 ELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQA 1024
L LEA D G + V V + P F +Y +P G +LQ++A
Sbjct: 1067 MLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
Query: 1025 QAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAA-LDREAQELYILKVMAVSGSKA 1080
D G + Y + + F + +G L LDRE ++L V A +
Sbjct: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH--- 1183
Query: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDP-TFLAVAENQPPGTSVGRVFATDRDSGPNGR 1139
+LG + V V + + N+ +P ++ + L + E GTSV V ATDRDSG G
Sbjct: 1184 DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
Query: 1140 LTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV 1199
+ Y + LS F I TG + T+ LD E ++SY + V D P +V++
Sbjct: 1244 VNYRI--LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
Query: 1200 AVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI---LYTL 1256
+L+ D + F AS A + + + GT + +QA D T YT
Sbjct: 1302 TLLNELDEAVQFSNASYEAA------ILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355
Query: 1257 TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSAR 1316
T LF + +G + + R + Y LT+ A D G P +++++ + VL
Sbjct: 1356 T-QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVL---- 1409
Query: 1317 LAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYTLVGGAD 1374
D + P V+ E G + +V A P+ G + ++L G +
Sbjct: 1410 ------DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG-N 1462
Query: 1375 PEGTFALDAAS---GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENE 1431
G F + + G +++ARPLD E + V ++ + +QV + D N+
Sbjct: 1463 IAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
Query: 1432 HAPAFARDPLA--LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLD 1489
+ P P +++ EN G A+ RA+D D G NS + Y + + A R+D
Sbjct: 1523 NPPVI-ESPFGYNVSVNENVGGGTAVVQVRATDRD-IGINSVLSYYITEGNKDM-AFRMD 1579
Query: 1490 ARTGALS---APRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF 1546
+G ++ AP +R++ L+ VE P +A V + DENDNAP+F
Sbjct: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPT-----LSATTHVYVTIVDENDNAPMF 1634
Query: 1547 ASPSRVRLPEDQPP--GPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSSTGALSV 1603
P L ++ P + + + A D D G V+Y + +G + FR+ G ++
Sbjct: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
Query: 1604 VRPLDRE-QRAEHVLTVVASDHG---SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659
+ LD E + L V A+D S ++T + V+V D+ND PTF +
Sbjct: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV 1754
Query: 1660 ENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFSLDPDTGVLTTLR--ALDREEQ 1714
PG + T A D D G NGQV Y + + F + P GVL + LDRE
Sbjct: 1755 TEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI 1814
Query: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LR 1773
NLT+ A+DRG PP + + V + V D ND+ P + +++ + E + +
Sbjct: 1815 AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVL 1874
Query: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
ASD D G N +L + I G+ AF ++ +G RPLDRE P ++L I +D +
Sbjct: 1875 ASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
Query: 1834 ALSATL---LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ----AHDPDAGA 1886
A LL + + D ND+ P F Y EV E+ PAGT L L A D D
Sbjct: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDI 1994
Query: 1887 NGHVTYYLGAGTAGAFLLEPSSG--ELRTAAALDREQC--PSYTFSVSAVDGAAAGPLST 1942
VTY L +G F + S+G +R+ +DRE P + A D G L++
Sbjct: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED---IGLLNS 2051
Query: 1943 TVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
T + IT+ D ND+ PTF + L + L P P ++ + A D D+G N ++YR
Sbjct: 2052 TAHLLITILDDNDNRPTFSPATLTVHLLENCP----PGFSVLQVTATDEDSGLNGELVYR 2107
Query: 2003 LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV-LFIVATDLGRPARSATGVIIVGLQGE 2061
+ + TG IRV + + ++ L +VATD G S T ++ + +
Sbjct: 2108 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
Query: 2062 AERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSI-----------LSGN 2110
+ P F ++ E+A PGT I + A+ N + Y I L N
Sbjct: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-LNPKLEYHIVGIVAKDDTDRLVPN 2226
Query: 2111 EKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL------QAESGGAFAFTVLTLTLQDA 2164
++ F++ +TG++ V+S + + + L + E + LT+ + D
Sbjct: 2227 QEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
Query: 2165 NDNAPRFLRPHYVAFLPESRPLEGP-----LLQVEADDLDQGSGGQISYSLAASQPARGL 2219
NDN P+F +P + + E R LEG L+ V A D D+G G ++Y+L P +
Sbjct: 2287 NDNTPQF-KPFGITYYME-RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
Query: 2220 FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ 2279
D + G + +D E + A+D GSP + + ++D NDN P Q
Sbjct: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
Query: 2280 P-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLD 2338
P ++ V ED +G+ I VT D DSG S + F++ G + + LD
Sbjct: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
Query: 2339 FEQCDRYQLQLLAHDGP-------HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391
E+ D Y L LA D P E + + V DVND P FS+ + + E+ P
Sbjct: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
Query: 2392 GSAILSVSATDRDSGANGHISYHLASPA-DGFSVDPNNGTLFTIVGTVALGHDGSGAVDV 2450
G++++++ ATD+D G NG ++Y L P + F VD ++G + T +
Sbjct: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLV-----TTQRPLQSYEKFSL 2579
Query: 2451 VLEARDHGAPGRAARATVHVQLQDQNDHAPSF------TLSHYRVAVTEDLPPGSTLLTL 2504
+ A D G P + V++ D ND+ P F T+ H R E++P S + +
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIR----EEIPLRSNVYEV 2635
Query: 2505 EATDADGSRSHAAVDYSII--SGN--WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
ATD D + AV YS + +GN W F ++P G + + L
Sbjct: 2636 YATDKDEGLN-GAVRYSFLKTAGNRDW-EFFIIDP--------------ISGLIQTAQRL 2679
Query: 2561 DFESLTQYNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVFTRA-----SYRV-TVPE 2613
D ES Y+L + A+D GQP P ++ P+ V + D++DN P+F R Y++ TVPE
Sbjct: 2680 DRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPE 2739
Query: 2614 DTPVGAELLHVE-ASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
+P G + +V A DAD GP+ +V + +++G+ F L + G L + LD E +A
Sbjct: 2740 HSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDREREAI 2798
Query: 2673 HQLVVQAAD------PAG--------AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAEN 2718
+V+A+ P G A L V + ++D+ND P F + VA +
Sbjct: 2799 FSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATD 2858
Query: 2719 QPPGTLVTTLHAIDGDAGAFGRLRYSLLE-------AGPGPEGREAFALNSSTGELRARV 2771
G+ + + A+D D G + YS+L A + + F + S G LR
Sbjct: 2859 AKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFD 2918
Query: 2772 PFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDE 2808
F F + + A D + + + + + +D+
Sbjct: 2919 LFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQ 2955
Score = 664 bits (1712), Expect = 0.0
Identities = 636/2215 (28%), Positives = 983/2215 (44%), Gaps = 183/2215 (8%)
Query: 799 VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
+ ED G+SV + A + P+ +SG + F+++ +G++ +PLDRE
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 859 P-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
+E V GV +V + + DVNDN+P F +V +P NT GTPI+ +
Sbjct: 100 EFTVEFSVSDHQGV----ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
Query: 918 ALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP- 976
A DPD G V ++ F +D G V ++R L A++L + A D
Sbjct: 156 ATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
Query: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---IT 1033
P ++ L +++ DV + + P F + Y ++ + GT V + A D G I
Sbjct: 215 PLSTLANLAIIITDV--QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
Query: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAE----LGQQTGTA 1089
Y + + +S F L+ SG L + LDRE ++ V G++ T T
Sbjct: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Query: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR-VFATDRDSGPNGRLTYSLQQLS 1148
T + +++ N+++P + +A+ E G ++ + D+D + + +
Sbjct: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
Query: 1149 EDSKAFRIHPQTGE------VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202
+S F I P + + + LD E Y + + P V + ++
Sbjct: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLI 451
Query: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262
+ NDN P F Q I + + V GT V T+ A D D G G + Y + +
Sbjct: 452 NENDNRPIFSQPL------YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PD 504
Query: 1263 LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLV----QVLPSARLA 1318
FSL +G ++ A L + LT+ A D G + +++ V +P+ +
Sbjct: 505 RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKD 564
Query: 1319 EPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT 1378
L E +P+ V L T + + P +TY++V +
Sbjct: 565 AYVGALRENEPSVTQLVRLRATDED-----------SPPN----NQITYSIVSASAFGSY 609
Query: 1379 F--ALDAASGRLYLARPLDFEA-GPPWRALTVRAEGPGGAGAR-LLRVQVQVQDENEHAP 1434
F +L G + ++RPLD+E LTV A G + V ++V DEN++ P
Sbjct: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Query: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPAL------RL 1488
F++ +++ EN GA + A+D D R R QE + +L R+
Sbjct: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLD--------RSREYGQESIIYSLEGSTQFRI 721
Query: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA- 1547
+AR+G ++ LDRET +L+V A D +++ + + + D NDN P +
Sbjct: 722 NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI-ATVNITLLDINDNHPTWKD 780
Query: 1548 SPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRP- 1606
+P + L E PP VVA DPDLGE + Y + + L+S+TG +
Sbjct: 781 APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAM 839
Query: 1607 LDREQRAEHV------LTVVASDHGSPPRSATQVLTVSV--ADVNDEAPTFQQQEYSVLL 1658
LDRE H + V +D G PP AT TV V D+ND PTFQ + +
Sbjct: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
Query: 1659 RENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQE 1715
E P G S+ + A D D G NG V+Y G+ F ++ +GV+ T LDRE
Sbjct: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
Query: 1716 EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRA 1774
E L V A D G+P + + T+ + V D ND PTF A ++ V E + + L
Sbjct: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
Query: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
+D DVG N +L Y I G+ G F + T+ LDRE A+ L +EA D G
Sbjct: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
Query: 1835 L--SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892
+ T + VTVLD ND+ P F +Y VPED+P G +LQL+A D D G G V Y
Sbjct: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY 1139
Query: 1893 YLGAGTAGA-FLLEPSSGEL-RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950
+ G G F + S+G L R LDRE+ S+ V A + GP+ ++V V + V
Sbjct: 1140 RILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-GPMRSSVRVIVYV 1198
Query: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010
D+ND AP F R T + + +A DRD+G + YR+
Sbjct: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVV---QATDRDSGDGGLVNYRILSGAEGK 1255
Query: 2011 TTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070
+D TG I ++ + ATD P + + L E + +F
Sbjct: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
Query: 2071 ASSEATIRENAPPGTPIVSPRAVHAGGTNGPITY---SILSGNEKGTFSIQPSTGAITVR 2127
AS EA I EN GT IV +A N ITY + S K F I TG ITV+
Sbjct: 1316 ASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFTVLT--LTLQDANDNAPRF-LRPHYVAFLPESR 2184
+D E L + A+ GG + + +T+ D NDN+PRF +PE
Sbjct: 1375 GL--VDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDC 1432
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAI---LDREIWA 2241
P+ + V+A D D GS GQ+ +SLA+ A G F + T +I + LDRE
Sbjct: 1433 PVGQRVATVKAWDPDAGSNGQVVFSLASGNIA-GAFEIVTTNDSIGEVFVARPLDREELD 1491
Query: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP--WELRVSEDALLGSEIAQVT 2299
L ++A+DRG+P L V ++D NDN P I P + + V+E+ G+ + QV
Sbjct: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
Query: 2300 GNDVDSG--PVLWYVLSPSGPQDPFSVGRYGGRVSLT-GPLDFEQCDRYQLQLLAHDGPH 2356
D D G VL Y ++ F + R G ++ P D E+ Y L D
Sbjct: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED--- 1608
Query: 2357 EGRANLT------VLVEDVNDNAPAFSQSLYQVMLLEHTPP-GSAILSVSATDRDSGANG 2409
EG L+ V + D NDNAP F Q Y+V+L E ++++++ A D D G NG
Sbjct: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668
Query: 2410 HISYHLASP--ADGFSVDPNNGTLFTIVGTVALGHDGS-GAVDVVLEARDHG---APGRA 2463
++Y + + + F +D + G I L ++ S G +++ A D +
Sbjct: 1669 TVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLT 1725
Query: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
+ TV V + D ND+ P+F + + PG + T A D D S + V+YSI+
Sbjct: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRD-SGPNGQVEYSIM 1784
Query: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP--LDFESLTQYNLTVAAADRGQPP 2581
G+ F + P G L + + LD E++ YNLT+ A DRG PP
Sbjct: 1785 DGDPLGEFVISP--------------VEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
Query: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641
SS + V + VLD+NDN PV +T+ E++PV + + HV ASDAD G + + F +
Sbjct: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
Query: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQ 2697
++G+ F ++ ++G + + LD E ++L + D P A + I +
Sbjct: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
Query: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH----AIDGDAGAFGRLRYSLLEAGPGPE 2753
D ND+ P F + V EN P GT +T L+ A+D D + + Y LL A G
Sbjct: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
Query: 2754 GREAFALNSSTG--ELRARVPFDYE--HTESFRLLVGAADAGNLSASVTVSVLVTGEDEY 2809
F +NSSTG +R+ V D E LL+ A D G L+++ + + + +++
Sbjct: 2009 ---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
Query: 2810 DPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGAL 2868
P F + E G S+ V ATDED G +G ++Y + A + F I+ TG +
Sbjct: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVI 2125
Query: 2869 YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA--RGPLPGSRSATVPVTVD 2921
+ G RE RL V+A RG +P S +A V + +D
Sbjct: 2126 RV---------------GNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILID 2165
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 922 bits (2383), Expect = 0.0
Identities = 837/2881 (29%), Positives = 1308/2881 (45%), Gaps = 214/2881 (7%)
Query: 49 LQIDEEQPAGT-LIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
+Q+ E QP G+ +I S L G L+Y +S G + ID +G+++ L
Sbjct: 724 IQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS---GGNEDSCFMIDMETGMLKILSPL 780
Query: 108 DREQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTR 161
DRE D+Y D A + V V D ND+ P F Q ++V E +
Sbjct: 781 DRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSE 840
Query: 162 YPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
A D D G G Y++ D +TF +++ G P LDRE + +
Sbjct: 841 IIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARP-------LDRELQHEH 891
Query: 222 MLQLEAYDGG--SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFA 279
L++EA D P + ++ V+L D+ND+ P F Y V E L G+ ++ + A
Sbjct: 892 SLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEA 951
Query: 280 SDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGA 339
D D G +G V Y + G+G F +D +G +++ + LDFE+++V+ L V+A+D G
Sbjct: 952 HDPDLGQSGQVRYSL---LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGK 1008
Query: 340 HPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF 398
L S +V V V D N+N +F S V E AP G LV +S D D
Sbjct: 1009 PVSLSSTCYVEVEVVDVNEN--LHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRD 1066
Query: 399 AHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEA 456
+ S+ G G F + + VI + RLDRE Y L V ATD G PL +
Sbjct: 1067 GEIRYSIRDGSGVGVFKIGEETGVIE---TSDRLDRESTSHYWLTVFATDQGVVPLSSFI 1123
Query: 457 AFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGA 516
+ V DVNDNAP +Y PE + E + VV++ A DPD +N ++ Y + G
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPE-IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGN 1182
Query: 517 HTHWFSIDPTSGIITTAA-SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNE 575
+FSI P +G+ITT + LD E + + L V TD G PP ++ A V V + D NDN+
Sbjct: 1183 PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
Query: 576 PQFQRTFYNASLPEGTQPG-------TCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
PQF + FY LPE +P V ATD D GP +SYS+ G +
Sbjct: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDG---NEHGK 1299
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFD-FTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYP 687
F I+ +G V + R +D ++ AVD G + ++ + + P P
Sbjct: 1300 FFIEPKTGVVSSKRF----SAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
Query: 688 REYAASISA----QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
+ S +S P ++ + + +P L + I GN F +D+ +G +
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIP---LWFDITGGNYDSHFDVDKGTGTII 1412
Query: 744 VAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDV 803
VA PL S L + A DG +V I ++ P F +Y +PED
Sbjct: 1413 VAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDT 1469
Query: 804 APGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGL--FSLDAVSGLLQTLRPLDRELLGPVL 861
AP T + + A + + + S DP L F LD +G L T LD E +
Sbjct: 1470 APETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHT 1529
Query: 862 ELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDP 921
+ VP AR+ V + D ND++P F A + + A G+ + + ALD
Sbjct: 1530 LTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDK 1589
Query: 922 DSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTS 980
D G N+ V +++ +G G +F +DP G ++ + L S ++L ++A D GSPP +
Sbjct: 1590 DKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
Query: 981 HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEG 1040
+R+ V +P+F S Y V+L + G+ V V A + + Y +
Sbjct: 1650 ITSVRIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS--VVYEIKDGN 1705
Query: 1041 ASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE 1100
F + P SG + + ALD E +Y L + + + G T T TV V + ++N+
Sbjct: 1706 TGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA----GLSTNT-TVLVHLQDEND 1760
Query: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDR-----------DSGPNGRLTYSLQQLSE 1149
++P + ++E+ S+ V TDR D N L Y + + S
Sbjct: 1761 NAPVFMQAEYTGLISES----ASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV 1816
Query: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPP--RSTTGTVHVAVLDLNDN 1207
+ F I TG + T+ +LD E+ S + VQV D G+P V V V+D+ND
Sbjct: 1817 HT-YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDC 1875
Query: 1208 SPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSL 1266
P F + A LP G V T+ A D D ++Y++T G E FS+
Sbjct: 1876 PPVFAKPLYEASLLLPTY------KGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929
Query: 1267 HPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAE 1326
+G L R Y LT+ A D G S+++ V+ + L
Sbjct: 1930 DYKTGAL--TVQNTTQLRSRYELTVRASD-GRFAGLTSVKINVKESKESHLK------FT 1980
Query: 1327 RDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASG 1386
+D + V V T AE L + +G+ EP L Y ++ +P+ F + SG
Sbjct: 1981 QDVYSAV-VKENSTEAETLAVITAIGN-PINEP-----LFYHIL---NPDRRFKISRTSG 2030
Query: 1387 RL-YLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALAL 1445
L P D E + + E + + V+V V+D+N++AP F P +
Sbjct: 2031 VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVV 2090
Query: 1446 PENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET 1505
+ E G + A D D G N +V Y L L G +S + + +T
Sbjct: 2091 KVDTEVGHVIRYVTAVDRDS-GRNGEVHYYLKEHHEHFQIGPL----GEISLKKQFELDT 2145
Query: 1506 -TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASP-SRVRLPEDQPPGPA 1563
L+ V A D A V +T N PVF P + E
Sbjct: 2146 LNKEYLVTVVAKD-----GGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP 2200
Query: 1564 ALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTVVAS 1622
+HV A P E +V Y + G F ++ +TG ++V+ PLD E + L++ A+
Sbjct: 2201 VVHVQANSP---EGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT 2257
Query: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
D A + + V D+ND P F QQ Y+V L E + GTS++ +RATD D N
Sbjct: 2258 D-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNR 2316
Query: 1683 QVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
++Y S + F +D TG+++ LR LD E+ + + V A D G P + V V
Sbjct: 2317 GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
Query: 1738 RVAVEDENDHAPTFG----SAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGD 1793
V V D ND+ P F A +S P G +T ++A D D +LQY IL G+
Sbjct: 2377 TVDVTDLNDNPPLFEQQIYEARISEHAPHG---HFVTCVKAYDADSSDIDKLQYSILSGN 2433
Query: 1794 PSGAFVLDLASGEFGTMRPLDRE-VEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHA 1852
FV+D A+G T+ L R ++P + L + DG ++ + VTV+ N H+
Sbjct: 2434 DHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLHS 2489
Query: 1853 PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELR 1912
PAF Y VE+ E+ P TL+++++ D D+G GHVTY++ A G++
Sbjct: 2490 PAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIF 2549
Query: 1913 TAAALDREQCPSYTFSVSAVDGAAAGPLS-TTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
T LDRE SV + A G ++ TV+V +T D ND+AP F + + +
Sbjct: 2550 TLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILT--DDNDNAPQFRATKYEVNI-- 2605
Query: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRL---AGTPPPGTTVDSYTGEIRVARSPVA 2028
G S + T + L A D D G+NA I Y + + + ++ +G I S +
Sbjct: 2606 -GSSAAKGTSVVKVL-ASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIG 2663
Query: 2029 LGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
L F+ A D G P++ + ++ V + + P+F T+ E+ P GT I
Sbjct: 2664 LENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEID 2723
Query: 2089 SPRAVHAGGTNGPITYSILSG-----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLV 2143
RA H +G + YS++ G N +F I +G + + + LD E + +
Sbjct: 2724 LIRAEH----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE--KSLDHETTKWYQFS 2777
Query: 2144 LQA----ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199
+ A + A +++ ++DANDN+P F Y AF+ E+ P ++Q+ A D D
Sbjct: 2778 ILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDAD 2837
Query: 2200 QGSGGQISYSLAASQPARGL--FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-A 2256
G+ GQ+ YSL SQ + F ++ TG ITT LD E ++ ++A+D G
Sbjct: 2838 SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQ 2897
Query: 2257 LVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSGPV---LWYV 2312
L +A + V V D ND+ P + ++ VSED G IA ++ D DS + + Y
Sbjct: 2898 LSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYF 2957
Query: 2313 LSPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVN 2370
++ P F+V +V + PLD E+ D Y L + A DG +A + V V D N
Sbjct: 2958 ITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDAN 3017
Query: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYH-LASPADGFSVDPNNG 2429
DN+P ++LY + E PG I+ +SATD D +N I+Y L S A+ F ++P+ G
Sbjct: 3018 DNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTG 3077
Query: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489
L T + L + +++ A D G GR +A++ + L+D ND+AP F+ Y +
Sbjct: 3078 ELKT---STPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAI 3132
Query: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPR 2549
V E+ PG+ L ++ATDAD + + YS+I G+ F +
Sbjct: 3133 TVFENTEPGTLLTRVQATDADAGLNRKIL-YSLIDSADGQ-FSIN--------------E 3176
Query: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQ-SSVVPVTVTVLDVNDNPPVFTRASYR 2608
G + L +PLD E Y L++ A D+G P + ++ V V+VLD+NDNPPVF Y
Sbjct: 3177 LSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYG 3236
Query: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCE 2668
TV ED VG E+L V A+ D + + +++ SG+ G F +D +G + + LD E
Sbjct: 3237 ATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYE 3296
Query: 2669 TQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT 2727
+ + L V+A D + +A V + V D+ND+ P F + +T ++E+ V T
Sbjct: 3297 SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVIT 3356
Query: 2728 LHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGA 2787
+ A D D + + YS+++ G +F ++ GE++ D E + L V A
Sbjct: 3357 VMADDADGPSNSHIHYSIIDGNQG----SSFTIDPVRGEVKVTKLLDRETISGYTLTVQA 3412
Query: 2788 ADAGNLSA--SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGAD 2845
+D G+ + TV++ V+ ++ PVF + + E G S+ + TDED +
Sbjct: 3413 SDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHN 3472
Query: 2846 G 2846
G
Sbjct: 3473 G 3473
Score = 810 bits (2093), Expect = 0.0
Identities = 774/2796 (27%), Positives = 1236/2796 (44%), Gaps = 209/2796 (7%)
Query: 136 INDHAPAFPQAR-AALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
+N H P F +QV E+ G+ + D D G G YA+SG F ++
Sbjct: 709 VNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMID 768
Query: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
G L + LDRE Y L + YD G P + A LL V ++D ND+ P
Sbjct: 769 METGM-------LKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPE 821
Query: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
F Q Y VSE S ++QV A+D D G NG VTY I FSID+ TG++
Sbjct: 822 FLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI----VTDTDTFSIDSVTGVV 877
Query: 315 QLERPLDFEQRRVHELVVQARDGGAH-PELGSAFVT-VHVRDANDNQPSMTVIFLSADGS 372
+ RPLD E + H L ++ARD P+L S V V + D NDN P+ F+ +
Sbjct: 878 NIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT----FIPPNYR 933
Query: 373 PQVSEAAPPGQLVARISVSDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLD 431
+V E P G ++ + DPD G V SL + GEG+F + D + V + ++LD
Sbjct: 934 VKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDV---DKLSGAVRIVQQLD 990
Query: 432 REERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNA-PAFDRQLYRPEPLPEVALPG 489
E++ YNL V A D G P + +V + V DVN+N P + E A G
Sbjct: 991 FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
Query: 490 SFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
S V+ V+A D D +G++ YS+ G+ F I +G+I T+ LD E L V
Sbjct: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVF 1110
Query: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
ATD G+ PL+S + + ++DVNDN PQ Y + E + +Q+ A D DS
Sbjct: 1111 ATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS 1170
Query: 610 FGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTT-RTLDRDQGPSSFDFTVTAVDGGGLK 666
L Y + +SG+P F I +G + TT R LDR+Q VT D G
Sbjct: 1171 NDKLMYKI-----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI-LEVTVTDNGSPP 1224
Query: 667 SMVYVKVFLS--DENDNPPQFYPREYAASISAQSPPG-------TAVLRLRAHDPDQGSH 717
+V + DENDN PQF + Y + + P + + A D D+G +
Sbjct: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
Query: 718 GRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVD 777
+SY I GN F ++ ++G+ V+ A L I A D G Q + R+
Sbjct: 1285 AEISYSIEDGNEHGKFFIEPKTGV--VSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLH 1342
Query: 778 ISIV--PGTPTPPI-FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPR 834
I + P PI FE+ + F+V E +G++ PPG P+ ++GG+
Sbjct: 1343 IEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-EPPG--IPLWFDITGGNYD 1399
Query: 835 GLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAF 894
F +D +G + +PLD E L V A G ++V+ D ND+ P F
Sbjct: 1400 SHFDVDKGTGTIIVAKPLDAEQKSN-YNLTVEATDGTTTILTQVFIKVI--DTNDHRPQF 1456
Query: 895 PAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG----GAFTVDPTTGHV 950
+ V++P +TAP T I + A+D D +++ +TL + F +DP TG +
Sbjct: 1457 STSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSL 1514
Query: 951 RLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLP 1010
L H L + RD P + + R+ V V D T AP F + +Y+ +
Sbjct: 1515 YTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD--TNDHAPWFTASSYKGRVY 1572
Query: 1011 SGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQEL 1067
G+ VLQV A D G + Y + + + F ++P G + LDR Q
Sbjct: 1573 ESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAE 1632
Query: 1068 YILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRV 1127
Y L V A + + T +VR+ + + SP+ + + ++E G+ VG V
Sbjct: 1633 YDLMVKATDKGSPPMSEIT---SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
Query: 1128 FATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187
A + S + Y ++ AF I+P +G + T + LD E Y L++Q +
Sbjct: 1690 TAHSQSS-----VVYEIKD-GNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMA 1743
Query: 1188 SPPRSTTGTVHVAVLDLNDNSPTFLQA--SGAAGGGLPIQ---VPDRVPPGTLVTTLQAK 1242
+TT VH+ D NDN+P F+QA +G I + DR P ++A
Sbjct: 1744 GLSTNTTVLVHLQ--DENDNAPVFMQAEYTGLISESASINSVVLTDRNVP----LVIRAA 1797
Query: 1243 DPDEGENGTILYTLTGPG-SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPR 1301
D D+ N ++Y + P F++ +G + T L E + T+ HD G+P
Sbjct: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL 1857
Query: 1302 SA--SLQLLVQVLP----SARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVA 1355
A + + V V+ A+P + + P V+TV A +
Sbjct: 1858 FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDA----------- 1906
Query: 1356 APEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGA 1415
+ + L Y++ G E F++D +G L + + LTVRA G
Sbjct: 1907 --DSSAFSQLIYSITEGNIGE-KFSMDYKTGALTVQNTTQLRSR---YELTVRAS--DGR 1958
Query: 1416 GARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYR 1475
A L V++ V++ E F +D + + EN L A G N + Y
Sbjct: 1959 FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAI---GNPINEPLFYH 2015
Query: 1476 LLRQEPPVPALRLDARTGALSAP-RGLDRETTPALLLLVEATDRPANASRRRAARVSARV 1534
+L P ++ +G LS DRE A ++VE T+ ++ A V +V
Sbjct: 2016 ILN---PDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSA---VAHVVVKV 2069
Query: 1535 FVTDENDNAPVFAS-PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFR 1593
V D+NDNAPVF + P + D G +V A D D G V Y L + HF+
Sbjct: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE-HFQ 2128
Query: 1594 LHSSTGALSVVRPLDREQ-RAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQ 1652
+ G +S+ + + + E+++TVVA D G+P SA ++ ++V +N P F++
Sbjct: 2129 I-GPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKP 2185
Query: 1653 EYSVLLRENNPPGTSLLTLRATDPD-VGANGQVTYGGVSSESFSLDPDTGVLTTLRALDR 1711
YS + E+ + ++ ++A P+ + +T G S+ F+++ +TGV+ + LD
Sbjct: 2186 FYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQ-FTINFNTGVINVIAPLDF 2244
Query: 1712 EEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT-LT 1770
E L++ A D + V V + V+D ND+ P F ++ + E T +
Sbjct: 2245 EAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVV 2303
Query: 1771 MLRASDPDVGANGQLQYRILDGDPSG--AFVLDLASGEFGTMRPLDREVEPAFQLRIEAR 1828
+RA+D D N + Y++ F +D ++G +R LD E + + A
Sbjct: 2304 QVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAV 2363
Query: 1829 DGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANG 1888
DGG P LS+ +++TV V D ND+ P F Y + E P G + ++A+D D+
Sbjct: 2364 DGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDID 2423
Query: 1889 HVTYYLGAGTAGAFLLEPSSGELRTAAALDREQC-PSYTFSVSAVDGAAAGPLSTTVSVT 1947
+ Y + +G + S+ + T + L R P Y+ ++S DG ++ V
Sbjct: 2424 KLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV----FRSSTQVH 2479
Query: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTP 2007
+TV N H+P F + + L P + + ++ D D+G + Y +
Sbjct: 2480 VTVIGGNLHSPAFLQNEYEVELAENAPLHT----LVMEVKTTDGDSGIYGHVTYHIVNDF 2535
Query: 2008 PPGTTVDSYTGEIRVARSPVALGPRDRVLFI--VATDLGRPARSATGVIIVGLQGEAERG 2065
+ G+I P ++V+ + +A D G T +I L + +
Sbjct: 2536 AKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI--LTDDNDNA 2593
Query: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE--KGTFSIQPSTG 2122
P+F E I +A GT +V A A G+N ITY+I + +E K I +G
Sbjct: 2594 PQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSG 2653
Query: 2123 AITVR-SAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLP 2181
IT + S GL+ E + S + ++ + + P+F P Y +
Sbjct: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713
Query: 2182 ESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG----LFHVDPTTGTITTTAILDR 2237
E P + E D + G + YSL F +D +G + LD
Sbjct: 2714 EDVP-----IGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDH 2768
Query: 2238 EI--WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSE 2294
E W + ++ T + +V S +++ V D NDN P P+E + E+ GS
Sbjct: 2769 ETTKWYQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSR 2827
Query: 2295 IAQVTGNDVDSGP--VLWYVLSPSGPQ---DPFSVGRYGGRVSLTGPLDFEQCDRYQLQL 2349
+ Q+ +D DSG + Y L S + F++ G ++ LD E+ D YQ+++
Sbjct: 2828 VIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKV 2887
Query: 2350 LAHDGPHEGRANLTVLVE----DVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405
+A D + + + T +V+ DVND+ P F+ +Y+ + E P G I +S TD DS
Sbjct: 2888 VASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADS 2947
Query: 2406 -GANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGR 2462
N ++Y + P F+V+ + + L + + + A D
Sbjct: 2948 EEINRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLDREKRDNYLLTITATDGTF--- 3003
Query: 2463 AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSI 2522
+++A V V++ D ND++P + Y + ED+ PG ++ + ATDAD RS+A + Y++
Sbjct: 3004 SSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD-IRSNAEITYTL 3062
Query: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD-RGQPP 2581
+ G+ F+L P E S PLD E Y+L V A D G+
Sbjct: 3063 L-GSGAEKFKLNPDTGELKTST--------------PLDREEQAVYHLLVRATDGGGRFC 3107
Query: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT- 2640
Q+S+V +T+ DVNDN P F+ Y +TV E+T G L V+A+DAD G + + ++
Sbjct: 3108 QASIV---LTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL 3164
Query: 2641 VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAH--FALAPVTIEVQD 2698
+ S D G F ++E SG ++L LD E QA + L ++A D A V + V D
Sbjct: 3165 IDSAD--GQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLD 3222
Query: 2699 VNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAF 2758
+ND+ P F +V+E+ GT V ++A D A + YS++ F
Sbjct: 3223 INDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE----HGKF 3278
Query: 2759 ALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAP 2816
+++S TG + DYE + + L V A D G +LS TV+V VT ++ PVF
Sbjct: 3279 SIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQD 3338
Query: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
+ + E A S+ V A D DG ++ + YS+
Sbjct: 3339 TYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSI 3374
Score = 757 bits (1954), Expect = 0.0
Identities = 780/2892 (26%), Positives = 1244/2892 (43%), Gaps = 262/2892 (9%)
Query: 106 VLDREQRDRYRFTAV-----TPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
+L+RE +D Y T A +V V+V D ND P F ++ +PE+TA T
Sbjct: 107 ILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
A DAD G G Y+ + F + G +V+TG LD
Sbjct: 167 SIARVSATDADIGTNGEFYYSFK--DRTDMFAIHPTSG-------VIVLTGRLDYLETKL 217
Query: 221 YMLQLEAYDG-----GSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
Y +++ A D GS + A L V + N+ AP +S S P
Sbjct: 218 YEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA----VTLSPSELDRDPAY 273
Query: 276 Q-VFASDADAGVNGAVT-----------YEINRRQSEGDGPFSIDAHTGLLQLERPLDFE 323
V D D G NG + R G + + A G+ P +
Sbjct: 274 AIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGY- 332
Query: 324 QRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQ 383
L +QA+D G P+ S V +HV + + V F ++SE APP
Sbjct: 333 -----NLTLQAKDKGTPPQFSSVKV-IHV--TSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
Query: 384 LVARISVSDPDDGDFAHVNVSLEG--GEGHFALSTQDSVIYLVCVARRLDREERDAYNLR 441
V + ++H+ + G+ F+L+ L+ + + R++ + L
Sbjct: 385 PVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTG---LISILEPVKRQQAAHFELE 437
Query: 442 VTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPD 501
VT +D +A ++ V N N P F + Y+ V + G+ V+ ++A DPD
Sbjct: 438 VTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPI-GTTVMSLSAVDPD 491
Query: 502 QGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP-QLIVVATDGGLPPLAS 560
+G NG VTYS+A H F+ID +G ++T+ +LDYEL P+ L + A+D GLP
Sbjct: 492 EGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
Query: 561 -SATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
++ L ++NDN P F++ ++P G V+A DAD L+ Y + A
Sbjct: 551 VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEA 608
Query: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGP--SSFDFTVTAVDGGGLKSMVYVKVFLS- 676
G + F ++ +SG + R+L G S +TA DG + +Y+ + ++
Sbjct: 609 G---NELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAA 665
Query: 677 ------------------------------------------DENDNPPQFYPR-EYAAS 693
N + PQF
Sbjct: 666 SHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQ 725
Query: 694 ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRAN 753
+ P G++V+ + + D D G +G+L Y + GN F +D ++G+L + PL R
Sbjct: 726 VKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETT 785
Query: 754 SVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQ 813
L I D G Q + + +V PP F Q Y V ED + + V+
Sbjct: 786 DKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 814 AHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEVR-AGSG 870
A + G VT S+ FS+D+V+G++ RPLDREL L++E R
Sbjct: 846 ATDKDLGPNGHVTYSIV--TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903
Query: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
P F+ V+V L+DVNDN P F P V + + GT I L A DPD G + +V
Sbjct: 904 EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR 963
Query: 931 FTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP-PRTSHFRLRVVVQ 989
++LL G G F VD +G VR+++ L + L + A+D G P +S + V V
Sbjct: 964 YSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVV 1023
Query: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDG---GPITYHLAAEGASSPFG 1046
DV P F+S + + G+ V+ V A D G I Y + F
Sbjct: 1024 DVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFK 1083
Query: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
+ ++G + LDRE+ Y L V A L + + + + + N+++P+ S
Sbjct: 1084 IGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPL---SSFIEIYIEVEDVNDNAPQTS 1140
Query: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
E + + EN P SV ++ A D DS N +L Y + F IHP+TG +TT
Sbjct: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITS-GNPQGFFSIHPKTGLITTT 1199
Query: 1167 -QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
+ LDREQQ + L V V D GSPP+ST V V +LD NDN P FLQ I+
Sbjct: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKF------YKIR 1253
Query: 1226 VPDRVPPGTLVTTLQ-------AKDPDEGENGTILYTL-TGPGSELFSLHPHSGELLTAA 1277
+P+R P + A D DEG N I Y++ G F + P +G + ++
Sbjct: 1254 LPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG--VVSS 1311
Query: 1278 PLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL 1337
A + +L++ A D G P +S++ +L ++ +++P P L +P +
Sbjct: 1312 KRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE-----WISKPKPSL---EPISFEESFF 1363
Query: 1338 TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
T T E ++G V + EP G+ L + + GG + + F +D +G + +A+PLD E
Sbjct: 1364 TFTVMESDPVAHMIG-VISVEPPGI-PLWFDITGG-NYDSHFDVDKGTGTIIVAKPLDAE 1420
Query: 1398 AGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT 1457
+ LTV E G L +V ++V D N+H P F+ + +PE+ P +
Sbjct: 1421 QKSNYN-LTV--EATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQ 1477
Query: 1458 FRASDADGPGPNSDVRYRLLRQEPP--VPALRLDARTGALSAPRGLDRETTPALLLLVEA 1515
A D D + + Y L P + RLD TG+L LD E L V
Sbjct: 1478 ISAVDQD---EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMV 1534
Query: 1516 TDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAALHVVARDPDL 1574
D+ R A V V V+D ND+AP F AS + R+ E G L V A D D
Sbjct: 1535 RDQDVPVKRNFARIV---VNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
Query: 1575 GEAARVSYRLASGGDGH-FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQ 1633
G+ A V Y + SG G+ F + G++ + LDR +AE+ L V A+D GSPP S
Sbjct: 1592 GKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEIT 1651
Query: 1634 VLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVS 1690
+ + V ++ +P F +EYSV L E G+ + + A + V Y G +
Sbjct: 1652 SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA-----HSQSSVVYEIKDGNT 1706
Query: 1691 SESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
++F ++P +G + T +ALD E L + Q T+ TV V ++DEND+AP
Sbjct: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLVHLQDENDNAPV 1764
Query: 1751 FGSAHLSLEVPEG--------QDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
F A + + E D ++RA+D D +N L Y I++ F +D
Sbjct: 1765 FMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDS 1824
Query: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLL--LTVTVLDANDHAPAFPVPAY 1860
++G T+ LD E F ++ D G P L A +TV V+D ND P F P Y
Sbjct: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG-AFLLEPSSGELRTAAALDR 1919
+ G ++ + A D D+ A + Y + G G F ++ +G L
Sbjct: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQL 1944
Query: 1920 EQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTP 1979
Y +V A DG AG SV I V++ + F T + + + S
Sbjct: 1945 RS--RYELTVRASDGRFAG----LTSVKINVKESKESHLKF-TQDVYSAVVKEN-STEAE 1996
Query: 1980 TLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIV 2039
TLA+ T N + Y + P + +G + +P ++ +V
Sbjct: 1997 TLAVITAIGNP----INEPLFYHIL-NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVV 2051
Query: 2040 -ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGG 2097
T+ +P+ A V+ V ++ + + P F A ++ + G I AV G
Sbjct: 2052 EVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSG 2111
Query: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV- 2156
NG + Y + +E F I P G I+++ LD ++ + + A+ GG AF+
Sbjct: 2112 RNGEVHYYLKEHHEH--FQIGP-LGEISLKKQFELD-TLNKEYLVTVVAKDGGNPAFSAE 2167
Query: 2157 LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
+ + + N P F +P Y A + ES + P++ V+A+ + G ++ YS+ P
Sbjct: 2168 VIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSITDGDPF 2224
Query: 2217 RGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT 2276
F ++ TG I A LD E +L + ATD + A + ++V D NDN P
Sbjct: 2225 -SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGA-HAEVFVDIIVDDINDNPPV 2282
Query: 2277 I-PQPWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVL--SPSGPQDPFSVGRYGGRV 2331
Q + + +SE +++G+ + QV D DS P + Y + + S D F V G +
Sbjct: 2283 FAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLI 2342
Query: 2332 SLTGPLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLYQVMLLEH 2388
SL LD+EQ ++ + + A DG ++ +TV V D+NDN P F Q +Y+ + EH
Sbjct: 2343 SLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEH 2402
Query: 2389 TPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAV 2448
P G + V A D DS + Y + S D + + + G + L + A+
Sbjct: 2403 APHGHFVTCVKAYDADSSDIDKLQYSILS-----GNDHKHFVIDSATGIITLSNLHRHAL 2457
Query: 2449 DVVLEARDHGAPGRAARAT-VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
+ G +T VHV + N H+P+F + Y V + E+ P + ++ ++ T
Sbjct: 2458 KPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTT 2517
Query: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
D D S + V Y I++ F + R G + LE LD E+ +
Sbjct: 2518 DGD-SGIYGHVTYHIVNDFAKDRFYINER---------------GQIFTLEKLDRETPAE 2561
Query: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
++V + + + V V + D NDN P F Y V + G ++ V AS
Sbjct: 2562 KVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
Query: 2628 DADPGPHGLVRFTVSSGDPS--GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG- 2684
DAD G + + + + + S E+++ SG + +L V+A D
Sbjct: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP 2681
Query: 2685 AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYS 2744
+ ++ V +++ P F + +V+E+ P GT + + A G + YS
Sbjct: 2682 SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHS-----GTVLYS 2736
Query: 2745 LLEAGPGPEGR--EAFALNSSTGELRARVPFDYEHTESFRLLVGA---ADAGNLSASVTV 2799
L++ G PE E+F ++ +G L+ D+E T+ ++ + A D + ASV V
Sbjct: 2737 LVK-GNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDV 2795
Query: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY- 2858
S+ V ++ PVF + + + E G + ++A+D D G +G V+YSL S
Sbjct: 2796 SIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVE 2855
Query: 2859 ----FGINQTTG 2866
F IN TG
Sbjct: 2856 VIESFAINMETG 2867
Score = 724 bits (1868), Expect = 0.0
Identities = 770/2874 (26%), Positives = 1235/2874 (42%), Gaps = 241/2874 (8%)
Query: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGA--------TVEVTVRVADINDHAPAFP 144
+ID +GVV AR LDRE + + D A TV V V + D+ND+ P F
Sbjct: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
Query: 145 QARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPV 204
++V E GT A D D G+ G Y+L G G F ++ G
Sbjct: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGA----- 982
Query: 205 PELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQAL-LDVTLLDIND--HAPAFNQSRYH 261
+ + +LD E + Y L + A D G P + ++V ++D+N+ H P F+
Sbjct: 983 --VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 262 AVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLD 321
V E GS V+ V A D DA +G + Y I R G G F I TG+++ LD
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI--RDGSGVGVFKIGEETGVIETSDRLD 1098
Query: 322 FEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP--SMTVIFLSADGSPQVSEAA 379
E + L V A D G P + + V D NDN P S V + P++ E +
Sbjct: 1099 RESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYY------PEIMENS 1152
Query: 380 PPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVARRLDREERDA 437
P V +I DPD + + G +G F++ + +I +R+LDRE++D
Sbjct: 1153 PKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLI--TTTSRKLDREQQDE 1210
Query: 438 YNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSF------ 491
+ L VT TD+GSPP A ++ + D NDN P F ++ Y+ LPE P
Sbjct: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIR-LPEREKPDRERNARRE 1269
Query: 492 -VVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITT---AASLDYELEPQPQLI 547
+ V A D D+G N +++YS+ G F I+P +G++++ +A+ +Y++ L
Sbjct: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-----LS 1324
Query: 548 VVATDGGLPPLASSATVSVALQDVNDNEPQ-----FQRTFYNASLPEGTQPGTCFLQVTA 602
+ A D G P S+T + ++ ++ +P F+ +F+ ++ E + P + V +
Sbjct: 1325 IKAVDNGRPQ--KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVME-SDPVAHMIGVIS 1381
Query: 603 TDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDG 662
+ P L + + G S F +D +G + + LD +Q S+++ TV A DG
Sbjct: 1382 VEPPGIP---LWFDITGGNYDSH---FDVDKGTGTIIVAKPLDAEQ-KSNYNLTVEATDG 1434
Query: 663 GG-LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLS 721
+ + V++KV D ND+ PQF +Y I + P T +L++ A D D+ + +L
Sbjct: 1435 TTTILTQVFIKVI--DTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN--KLI 1490
Query: 722 YHILAGNSP---PLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDI 778
Y + + P F LD +G L + L A L + D AR+ +
Sbjct: 1491 YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVV 1550
Query: 779 SIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLF 837
++ P F Y V E A G+ V V A G+ A V S+ G+ F
Sbjct: 1551 NVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSF 1610
Query: 838 SLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897
+D V G ++T + LDR + G PP + VR+ + ++ SP F +
Sbjct: 1611 MIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSK 1670
Query: 898 EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPL 956
E +V L + G+ + + A S V + + G G AF ++P +G + + L
Sbjct: 1671 EYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKAL 1725
Query: 957 GPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAG 1016
P + L ++ + +++ + V +QD AP F Y + +
Sbjct: 1726 DFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDENDN--APVFMQAEYTGLISESASIN 1781
Query: 1017 TQVLQ----------VQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQE 1066
+ VL A + YH+ + F ++ +G + +LD E
Sbjct: 1782 SVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETS 1841
Query: 1067 LYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR 1126
++ V L + A V V +++ N+ P ++ ++ G V
Sbjct: 1842 IFHFTVQVHDMGTPRLFAEYA-ANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT 1900
Query: 1127 VFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDG 1186
V ATD DS +L YS+ + + K F + +TG +T T + +S Y+L V+ DG
Sbjct: 1901 VNATDADSSAFSQLIYSITEGNIGEK-FSMDYKTGALTVQNTT--QLRSRYELTVRASDG 1957
Query: 1187 GSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDE 1246
++ V + V + ++ F Q +A + + TL +P
Sbjct: 1958 RFAGLTS---VKINVKESKESHLKFTQDVYSA-----VVKENSTEAETLAVITAIGNPI- 2008
Query: 1247 GENGTILYTLTGPGSELFSLHPHSGEL-LTAAPLIRAERPHYVLTLSAHDQGSPPRSASL 1305
N + Y + P F + SG L T P R ++ + + + ++ P SA
Sbjct: 2009 --NEPLFYHILNPDRR-FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKP--SAVA 2063
Query: 1306 QLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGL--RPGSLLGSVAAPE--PAG 1361
++V+V+ + +++ APV V L A + G ++ V A +
Sbjct: 2064 HVVVKVI-----------VEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
Query: 1362 VGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLR 1421
G + Y L + F + G + L + + + +TV A+ GG A
Sbjct: 2113 NGEVHYYL---KEHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKD-GGNPAFSAE 2167
Query: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEP 1481
V V + N+ P F + + + E+ + + + +A+ +G V Y + +P
Sbjct: 2168 VIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEG----LKVFYSITDGDP 2223
Query: 1482 PVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDEND 1541
++ TG ++ LD E PA L + ATD A A V + V D ND
Sbjct: 2224 -FSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH----AEVFVDIIVDDIND 2278
Query: 1542 NAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLA---SGGDGHFRLHSS 1597
N PVFA S V L E G + + V A D D +SY++ S HF + SS
Sbjct: 2279 NPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
Query: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL 1657
TG +S++R LD EQ +H + V A D G P S+ ++TV V D+ND P F+QQ Y
Sbjct: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
Query: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQ 1714
+ E+ P G + ++A D D ++ Y G + F +D TG++T L L R
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT-LSNLHRHAL 2457
Query: 1715 E---EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM 1771
+ +NL+V S Q V V V N H+P F +E+ E TL M
Sbjct: 2458 KPFYSLNLSVSDGVFRSSTQ-----VHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM 2512
Query: 1772 -LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREV--EPAFQLRIEAR 1828
++ +D D G G + Y I++ F ++ G+ T+ LDRE E +R+ A+
Sbjct: 2513 EVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLDRETPAEKVISVRLMAK 2571
Query: 1829 DGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANG 1888
D G T+ + +T D ND+AP F Y V + GT ++++ A D D G+N
Sbjct: 2572 DAGGKVAFCTVNVILT--DDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNA 2629
Query: 1889 HVTYYLGAGTAGA---FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
+TY + A + + SG + T +L + +TF V AVD + S
Sbjct: 2630 DITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESV--- 2686
Query: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRD---AGANASILYR 2002
V + V+ + P ++LP+ F T T++ + D A + ++LY
Sbjct: 2687 VLVYVKIL----------PPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYS 2736
Query: 2003 LA-GTPPPGT-----TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV-II 2055
L G P +D +G +++ +S + I+A V +
Sbjct: 2737 LVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVS 2796
Query: 2056 VGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKG- 2113
+ ++ + P F + EA I EN P G+ ++ RA A GTNG + YS+
Sbjct: 2797 IQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEV 2856
Query: 2114 --TFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA----FAFTVLTLTLQDANDN 2167
+F+I TG IT + + LD E ++ + A G + ++ +T+ D ND+
Sbjct: 2857 IESFAINMETGWIT--TLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDS 2914
Query: 2168 APRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS-GGQISYSLAASQPARGLFHVDPTT 2226
PRF Y + E P G + + D D Q++Y + P G F V+
Sbjct: 2915 PPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL-GQFAVETIQ 2973
Query: 2227 GT--ITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WEL 2283
+ LDRE L + ATD A + V V+D NDN P + +
Sbjct: 2974 NEWKVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSD 3030
Query: 2284 RVSEDALLGSEIAQVTGNDVD--SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQ 2341
+ ED L G I Q++ D D S + Y L SG + F + G + + PLD E+
Sbjct: 3031 TIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREE 3089
Query: 2342 CDRYQLQLLAHDGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSA 2400
Y L + A DG +A++ + +EDVNDNAP FS Y + + E+T PG+ + V A
Sbjct: 3090 QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
Query: 2401 TDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGA 2459
TD D+G N I Y L ADG FS++ +G + L + + L+A D G
Sbjct: 3150 TDADAGLNRKILYSLIDSADGQFSINELSGIIQL---EKPLDRELQAVYTLSLKAVDQGL 3206
Query: 2460 PGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAV 2518
P R A TV V + D ND+ P F Y V+ED+ G+ +L + A D ++A +
Sbjct: 3207 PRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD-IEANAEI 3265
Query: 2519 DYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRG 2578
YSIISGN F ++ + G + ++E LD+ES +Y LTV A D G
Sbjct: 3266 TYSIISGNEHGKFSIDSKT--------------GAVFIIENLDYESSHEYYLTVEATDGG 3311
Query: 2579 QPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVR 2638
P S V V V V D+NDN PVF++ +Y + ED + ++ V A DAD + +
Sbjct: 3312 TPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIH 3371
Query: 2639 FTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG-AHFALAPVTIEVQ 2697
+++ G+ F +D G +++ LD ET + + L VQA+D V I+V
Sbjct: 3372 YSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVS 3431
Query: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA 2757
DVND+ P F S + EN+P G V L D D+ G + + G +A
Sbjct: 3432 DVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTG---NDEKA 3488
Query: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLA 2815
F +N G L + + + L V AD G LS+ + + V E Y P L
Sbjct: 3489 FEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILP 3547
Query: 2816 PAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGAL 2868
G +G + ATD+D + YSL F ++ T G L
Sbjct: 3548 LEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKL 3599
Score = 699 bits (1803), Expect = 0.0
Identities = 725/2762 (26%), Positives = 1185/2762 (42%), Gaps = 248/2762 (8%)
Query: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
T L+RE + HY L ++A + + A+ + V +LD ND P F+ + Y + E+ A
Sbjct: 105 TAILNREVKDHYTLIVKALEKNTNVE-ARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTA 163
Query: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
+ + +V A+DAD G NG Y R F+I +G++ L LD+ + +++E
Sbjct: 164 IRTSIARVSATDADIGTNGEFYYSFKDRTD----MFAIHPTSGVIVLTGRLDYLETKLYE 219
Query: 330 LVVQARDGGAHPELGS-----AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQL 384
+ + A D G S A +TVH+ AN+ P +T + L SP + P +
Sbjct: 220 MEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL----SPSELDRDPAYAI 275
Query: 385 VARISVSDPDDGDFAHVNVSLEGGEGHF--ALSTQDSVIYLVCVARRLDREERD-AYNLR 441
V +GD A +++ F S S Y V +D + YNL
Sbjct: 276 VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLT 335
Query: 442 VTATDSGSPPLRAEAAFVLHVTDVNDNA--PAFDRQLYRPEPLPEVALPGSFVVRVTARD 499
+ A D G+PP + + V+HVT A F++ +YR E + E A P + VV V A
Sbjct: 336 LQAKDKGTPP-QFSSVKVIHVTSPQFKAGPVKFEKDVYRAE-ISEFAPPNTPVVMVKA-- 391
Query: 500 PDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559
++ + + PG FS++ +G+I+ + + +L V +D
Sbjct: 392 IPAYSHLRYVFKSTPGKAK--FSLNYNTGLISILEPVKRQQAAHFELEVTTSD-----RK 444
Query: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
+S V V + N N P+F +T Y A+ E GT + ++A D D G G ++YS
Sbjct: 445 ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYS--- 501
Query: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG---GLKSMVYVKVFLS 676
+ + PF ID +G V T+ LD + P + + A D G + V + L+
Sbjct: 502 -IANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLN 560
Query: 677 DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD 736
+ NDN P F +I G + + A D D+ + Y I AGN F+L+
Sbjct: 561 NLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLN 618
Query: 737 EQSGLLTVAWPLARRANSVV---QLEIGAEDGG-------------------GLQAEPSA 774
SG+L++ L + V L I A DG LQ E +
Sbjct: 619 PNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETG 678
Query: 775 RVDI-----------------------SIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGI 811
+ S P L V E+ G+SV
Sbjct: 679 VAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIF 738
Query: 812 VQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSG 870
+ + + G + ++SGG+ F +D +G+L+ L PLDRE G
Sbjct: 739 MNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLG 798
Query: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
+P A + V++ D NDN P F V + + + I + A D D G N VT
Sbjct: 799 IPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVT 858
Query: 931 FTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG--SPPRTSHFRLRVVV 988
++++ F++D TG V + RPL H L++EARD P S ++V +
Sbjct: 859 YSIVT-DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSL 917
Query: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPF 1045
+DV P F P YRV + GT ++ ++A PD G + Y L G + F
Sbjct: 918 EDVNDN--PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-F 974
Query: 1046 GLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL 1105
++ SG + + LD E +++Y L V A K T V V +N+N H P
Sbjct: 975 DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVF 1034
Query: 1106 SEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTT 1165
S V E+ P G+ V V A D D+ +G + YS++ F+I +TG + T
Sbjct: 1035 SSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD-GSGVGVFKIGEETGVIET 1093
Query: 1166 LQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
LDRE S Y L V D G P S+ +++ V D+NDN+P + P+
Sbjct: 1094 SDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSE---------PVY 1144
Query: 1226 VP---DRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAA-PLI 1280
P + P V ++A DPD N ++Y +T G FS+HP +G + T + L
Sbjct: 1145 YPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLD 1204
Query: 1281 RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340
R ++ ++L ++ D GSPP+S +++V++L + P ++ +P
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDE---NDNKPQFLQKFYKIRLPEREKPD 1261
Query: 1341 AAEGLRPGSLLGSVAAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAG 1399
R L +A + G A ++Y++ G + G F ++ +G + R F A
Sbjct: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDG-NEHGKFFIEPKTGVVSSKR---FSAA 1317
Query: 1400 PPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459
+ L+++A G + ++ ++ ++ P+ +P++ + +TF
Sbjct: 1318 GEYDILSIKAV-DNGRPQKSSTTRLHIEWISKPKPSL--EPISFE--------ESFFTFT 1366
Query: 1460 ASDADGPGPNSDVRYRLLRQEPPVPA------------LRLDARTGALSAPRGLDRETTP 1507
++D P + + + + P +P +D TG + + LD E
Sbjct: 1367 VMESD---PVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
Query: 1508 ALLLLVEATDRPANASRRRAARVSARVF--VTDENDNAPVFA-SPSRVRLPEDQPPGPAA 1564
L VEATD + +VF V D ND+ P F+ S V +PED P
Sbjct: 1424 NYNLTVEATD--------GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI 1475
Query: 1565 LHVVARDPDLGEAARVSYRLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
L + A D D E ++ Y L S D FRL +TG+L LD E +H LTV+
Sbjct: 1476 LQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533
Query: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
D P + + V+V+D ND AP F Y + E+ G+ +L + A D D G
Sbjct: 1534 VRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGK 1593
Query: 1681 NGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
N +V Y G SF +DP G + T + LDR Q E +L V A D+GSPP +V
Sbjct: 1594 NAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSV 1653
Query: 1738 RVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGA 1797
R+ V ++ +P F S S+E+ E + + + + + Y I DG+ A
Sbjct: 1654 RIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYEIKDGNTGDA 1709
Query: 1798 FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPV 1857
F ++ SG T + LD E P + L I+ + LS + V + D ND+AP F
Sbjct: 1710 FDINPHSGTIITQKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQ 1767
Query: 1858 PAYSVEVPEDVPAGTLLLQ-------LQAHDPDAGANGHVTYYLGAGTAGA-FLLEPSSG 1909
Y+ + E +++L ++A D D +N + Y++ + F ++ S+G
Sbjct: 1768 AEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG 1827
Query: 1910 ELRTAAALDREQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTF--PTSPLR 1966
+ T +LD E+ + F+V D G +VT+ V D+ND P F P
Sbjct: 1828 AIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEAS 1887
Query: 1967 LRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARS 2025
L LP + + + T+ A D D+ A + ++Y + G ++D TG + V +
Sbjct: 1888 LLLP------TYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNT 1941
Query: 2026 PVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGT 2085
R R V GR A + + + ++ E +F + A ++EN+
Sbjct: 1942 TQL---RSRYELTVRASDGRFAGLTS--VKINVKESKESHLKFTQDVYSAVVKENSTEAE 1996
Query: 2086 PIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
+ A+ N P+ Y IL+ + + F I ++G ++ + D E +V++
Sbjct: 1997 TLAVITAI-GNPINEPLFYHILNPDRR--FKISRTSGVLST-TGTPFDREQQEAFDVVVE 2052
Query: 2146 A---ESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS 2202
A A V+ + ++D NDNAP F+ Y A + + + V A D D G
Sbjct: 2053 VTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR 2112
Query: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLV-LMATDRGSPALVGSA 2261
G++ Y L F + P G I+ + + + LV ++A D G+PA SA
Sbjct: 2113 NGEVHYYLKEHHEH---FQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAF--SA 2166
Query: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQD 2320
+ V + N P +P + ++E + S + V N + G ++Y ++ P
Sbjct: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSITDGDPFS 2225
Query: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPHEGRANLTVLVEDVNDNAPAFS 2377
F++ G +++ PLDFE Y+L + A D G H + ++V+D+NDN P F+
Sbjct: 2226 QFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFA 2284
Query: 2378 QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL----ASPADGFSVDPNNGTLFT 2433
Q Y V L E + G++++ V ATD DS N ISY + + D F VD + G L +
Sbjct: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTG-LIS 2343
Query: 2434 IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
++ T L ++ S + + A D G P ++ V V + D ND+ P F Y ++E
Sbjct: 2344 LLRT--LDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
Query: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGC 2553
P G + ++A DAD S + YSI+SGN + F ++ A G
Sbjct: 2402 HAPHGHFVTCVKAYDADSS-DIDKLQYSILSGNDHKHFVID--------------SATGI 2446
Query: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPE 2613
+ L Y+L ++ +D S V VTV+ N + P F + Y V + E
Sbjct: 2447 ITLSNLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAE 2503
Query: 2614 DTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARH 2673
+ P+ ++ V+ +D D G +G V + + + F ++E G + LD ET A
Sbjct: 2504 NAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEK 2562
Query: 2674 QLVVQ-AADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAID 2732
+ V+ A AG A V + + D ND+ P F ++ + GT V + A D
Sbjct: 2563 VISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASD 2622
Query: 2733 GDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN 2792
D G+ + Y++ +E +N +G + + E F V A D G+
Sbjct: 2623 ADEGSNADITYAI--EADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2680
Query: 2793 LS--ASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLY 2850
S + V V V + + P F P + F V E G + ++A G VLY
Sbjct: 2681 PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLY 2735
Query: 2851 SL 2852
SL
Sbjct: 2736 SL 2737
Score = 624 bits (1609), Expect = e-178
Identities = 661/2374 (27%), Positives = 1013/2374 (42%), Gaps = 165/2374 (6%)
Query: 53 EEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR 112
E P +IG IS P PL + I+ G + +D+ +G + A+ LD EQ+
Sbjct: 1369 ESDPVAHMIGVISVEPPG---IPLWFDIT---GGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422
Query: 113 DRYRFTAVTPDGAT---VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARD 169
Y T DG T +V ++V D NDH P F ++ + +PE TA T A D
Sbjct: 1423 SNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVD 1482
Query: 170 ADAGRLGTQGYALSGDGAG-ETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAY 228
D S D + FRL+ G L + +LD E + L +
Sbjct: 1483 QDEKNKLIYTLQSSRDPLSLKKFRLDPATG-------SLYTSEKLDHEAVHQHTLTVMVR 1535
Query: 229 DGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNG 288
D P +R A + V + D NDHAP F S Y V ES A GS VLQV A D D G N
Sbjct: 1536 DQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNA 1595
Query: 289 AVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFV 348
V Y I F ID G ++ + LD + ++L+V+A D G+ P V
Sbjct: 1596 EVLYSI--ESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSV 1653
Query: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408
+ V A++ P F S + S ++SE G V ++ + V +G
Sbjct: 1654 RIFVTIADNASPK----FTSKEYSVELSETVSIGSFVGMVTAHSQS----SVVYEIKDGN 1705
Query: 409 EGH-FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467
G F ++ I + LD E Y L + T+ L ++H+ D ND
Sbjct: 1706 TGDAFDINPHSGTI---ITQKALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDEND 1760
Query: 468 NAPAFDRQLYRPEPLPEVALPGSFVVR-------VTARDPDQGTNGQVTYSLA-PGAHTH 519
NAP F + Y + E A S V+ + A D D+ +N + Y + P HT
Sbjct: 1761 NAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT- 1818
Query: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLAS--SATVSVALQDVNDNEPQ 577
+F+ID ++G I T SLDYE V D G P L + +A V+V + D+ND P
Sbjct: 1819 YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPV 1878
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F + Y ASL T G + V ATDADS F L YS+ G + F +D +G
Sbjct: 1879 FAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEG---NIGEKFSMDYKTGA 1935
Query: 638 VCTTRTLDRDQGPSSFDFTVTAVDG--GGLKSMVYVKVFLSDENDNPPQFYPREYAASIS 695
+ T Q S ++ TV A DG GL S VK+ + + ++ +F Y+A +
Sbjct: 1936 LTVQNT---TQLRSRYELTVRASDGRFAGLTS---VKINVKESKESHLKFTQDVYSAVVK 1989
Query: 696 AQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLL-TVAWPLARRANS 754
S + + A + L YHIL N F + SG+L T P R
Sbjct: 1990 ENSTEAETLAVITA--IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQE 2045
Query: 755 VVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA 814
+ + + A V + + P+F L Y V D G + V A
Sbjct: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTA 2105
Query: 815 -HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873
GR V L + F + + G + + + + L + V A G P
Sbjct: 2106 VDRDSGRNGEVHYYLK--EHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNP 2162
Query: 874 AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933
AF+ A V V + +N P F P + + + +P+ ++A P+ +V +++
Sbjct: 2163 AFS-AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE---GLKVFYSI 2218
Query: 934 LAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVG 992
G FT++ TG + ++ PL PA++L + A D + F + ++V D+
Sbjct: 2219 TDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF-VDIIVDDIN 2277
Query: 993 TRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASS--PFGL 1047
P F +Y V L + GT V+QV+A D P I+Y + + S F +
Sbjct: 2278 DN--PPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV 2335
Query: 1048 EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSE 1107
+ +G + + LD E + + V AV G L TV V+ LN N P L E
Sbjct: 2336 DSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDV-IVTVDVTDLNDN---PPLFE 2391
Query: 1108 DPTFLA-VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
+ A ++E+ P G V V A D DS +L YS+ D K F I TG + TL
Sbjct: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILS-GNDHKHFVIDSATG-IITL 2449
Query: 1167 QTLDREQ-QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
L R + Y L + V DG RS+T VHV V+ N +SP FLQ ++
Sbjct: 2450 SNLHRHALKPFYSLNLSVSDGVF--RSST-QVHVTVIGGNLHSPAFLQ------NEYEVE 2500
Query: 1226 VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERP 1285
+ + P TLV ++ D D G G + Y + ++ G++ T L R
Sbjct: 2501 LAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPA 2560
Query: 1286 HYVLT--LSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
V++ L A D G ++ +++ D A + A V + +AA+
Sbjct: 2561 EKVISVRLMAKDAGGKVAFCTVNVIL---------TDDNDNAPQFRATKYEVNIGSSAAK 2611
Query: 1344 GLRPGSLLGSVAAPEPAGVGALTYTLVGGADP-EGTFALDAASGRLYLARPLDFEAGPPW 1402
G +L S A + +TY + ++ + ++ SG + L +
Sbjct: 2612 GTSVVKVLASDA--DEGSNADITYAIEADSESVKENLEINKLSGVITTKESL-IGLENEF 2668
Query: 1403 RALTVRAEGPGGAGAR-LLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
VRA G ++ V V++ P F+ + E+ G + RA
Sbjct: 2669 FTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE 2728
Query: 1462 DADGPGPNSDVRYRLLRQEPPV----PALRLDARTGALSAPRGLDRETTPALLLLVEATD 1517
+ V Y L++ P + +D ++G L + LD ETT + A
Sbjct: 2729 H------SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILA-- 2780
Query: 1518 RPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLPEDQPPGPAALHVVARDPDLGE 1576
R A V + V D NDN+PVF +SP + E+ P G + + A D D G
Sbjct: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840
Query: 1577 AARVSYRLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR-SA 1631
+V Y L F ++ TG ++ ++ LD E+R + + VVASDHG + S+
Sbjct: 2841 NGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSS 2900
Query: 1632 TQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPD-VGANGQVTY---G 1687
T ++ V+V DVND P F + Y + E++P G + L TD D N QVTY G
Sbjct: 2901 TAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG 2960
Query: 1688 GVSSESFSLD--PDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEN 1745
G F+++ + + + LDRE+++ LT+ A D + V V V D N
Sbjct: 2961 GDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS---SKAIVEVKVLDAN 3017
Query: 1746 DHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLAS 1804
D++P S +PE P L M + A+D D+ +N ++ Y +L G + F L+ +
Sbjct: 3018 DNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDT 3076
Query: 1805 GEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEV 1864
GE T PLDRE + + L + A DGG A+++LT+ D ND+AP F Y++ V
Sbjct: 3077 GELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYAITV 3134
Query: 1865 PEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPS 1924
E+ GTLL ++QA D DAG N + Y L G F + SG ++ LDRE
Sbjct: 3135 FENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAV 3194
Query: 1925 YTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA-- 1982
YT S+ AVD L+ T +V ++V D+ND+ P F G + S L
Sbjct: 3195 YTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVF-------EYREYGATVSEDILVGT 3247
Query: 1983 -LATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVA 2040
+ + A RD ANA I Y ++G ++DS TG + + + + L + A
Sbjct: 3248 EVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEA 3307
Query: 2041 TDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGG-TN 2099
TD G P+ S + V + + P F + + I E+A +++ A A G +N
Sbjct: 3308 TDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSN 3367
Query: 2100 GPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTV 2156
I YSI+ GN+ +F+I P G + V LD E L +QA G+ T
Sbjct: 3368 SHIHYSIIDGNQGSSFTIDPVRGEVKVTKL--LDRETISGYTLTVQASDNGSPPRVNTTT 3425
Query: 2157 LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
+ + + D NDNAP F R +Y + E++P+ +LQ+ D D G + +
Sbjct: 3426 VNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND 3485
Query: 2217 RGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT 2276
F V+P G + T++ + R+ L + D G P L + + VI+ + P
Sbjct: 3486 EKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA 3544
Query: 2277 I-PQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG 2335
I P + S + G I ++ D D L Y L P + FSV GG++
Sbjct: 3545 ILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQ-MDNLFSVSSTGGKLIAHK 3603
Query: 2336 PLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDV 2369
LD Q Y L + DG A++TV + V
Sbjct: 3604 KLDIGQ---YLLNVSVTDGKFTTVADITVHIRQV 3634
Score = 572 bits (1473), Expect = e-162
Identities = 603/2209 (27%), Positives = 938/2209 (42%), Gaps = 242/2209 (10%)
Query: 786 TPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
TP F L+Y +V E+ A T VG PV + + P VSG
Sbjct: 30 TPLQFTHLEYNVTVQENSAAKTYVG-----------HPVKMGVYITHPAWEVRYKIVSGD 78
Query: 846 LQTLRPLDRELLGPVLELEVRAGSGVPPAF----------------------AVARVRVL 883
+ L + +LG L +R G A +VRV
Sbjct: 79 SENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQ 138
Query: 884 LDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTV 943
+ D ND P F +V LP NTA T I + A D D G N ++ F +
Sbjct: 139 VLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-KDRTDMFAI 197
Query: 944 DPTTGHVRLMRPLGPSGGPAHELELEARDGG-----SPPRTSHFRLRVVVQDVG------ 992
PT+G + L L +E+E+ A D G S +S +L V ++
Sbjct: 198 HPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVI 257
Query: 993 ---TRGLAPRFNSPTYRV------------DLPS-GTTAGTQVLQVQAQAPDGGPITYHL 1036
T + P Y + D+ S AG + Q + G Y +
Sbjct: 258 TAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKV 317
Query: 1037 AAEGA----SSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092
A G S PFG L ++A + +KV+ V+ + + G
Sbjct: 318 KAIGGIDWDSHPFGYN-----LTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPV------- 365
Query: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK 1152
+ +D ++E PP T V V A S L Y + +K
Sbjct: 366 -----------KFEKDVYRAEISEFAPPNTPVVMVKAIPAYS----HLRYVFKSTPGKAK 410
Query: 1153 AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFL 1212
F ++ TG ++ L+ + R+Q + ++L V D R + V V VL N N P F
Sbjct: 411 -FSLNYNTGLISILEPVKRQQAAHFELEVTTSD-----RKASTKVLVKVLGANSNPPEFT 464
Query: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGE 1272
Q + A + VP GT V +L A DPDEGENG + Y++ F++ +G
Sbjct: 465 QTAYKAA------FDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGA 518
Query: 1273 LLTAAPLIRAERPH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAA 1331
+ T+ L P Y L + A D G P R L L + P + +
Sbjct: 519 VSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTI 578
Query: 1332 PVPV-----VLTVTAAEG---------LRPGSLLGSVAAPEPAGVGALTYTLVGGADPEG 1377
P + + TV+A + + G+ L + +GV +L +L+ G +
Sbjct: 579 PRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKV 638
Query: 1378 TF---ALDAASGRLYLARPL--DFEAGPPWRALTVRAEGPGGAG--------ARLLRVQV 1424
+F + A G + A PL + + + ++ E G A A L Q
Sbjct: 639 SFHSLRITATDGENF-ATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
Query: 1425 QVQD-------ENEHAPAFARD-PLALALPENPEPGAALYTFRASDADGPGPNSDVRYRL 1476
+V+D N H P F P + + EN G+++ ++D D G N + Y +
Sbjct: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLD-TGFNGKLVYAV 756
Query: 1477 LRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFV 1536
+D TG L LDRETT L + D ++AA V V
Sbjct: 757 SGGNED-SCFMIDMETGMLKILSPLDRETTDKYTLNITVYDL---GIPQKAAWRLLHVVV 812
Query: 1537 TDENDNAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH 1595
D NDN P F S V + ED+ + V A D DLG V+Y + + D F +
Sbjct: 813 VDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT-FSID 871
Query: 1596 SSTGALSVVRPLDREQRAEHVLTVVASDHG--SPPRSATQVLTVSVADVNDEAPTFQQQE 1653
S TG +++ RPLDRE + EH L + A D P +T V+ VS+ DVND PTF
Sbjct: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPN 931
Query: 1654 YSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS--SESFSLDPDTGVLTTLRALDR 1711
Y V +RE+ P GT ++ L A DPD+G +GQV Y + +F +D +G + ++ LD
Sbjct: 932 YRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDF 991
Query: 1712 EEQEEINLTVYAQDRGSPPQLT---HVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768
E+++ NLTV A+D+G P L+ +V V V +EN H P F S V E +
Sbjct: 992 EKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGS 1051
Query: 1769 LTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEA 1827
L M + A D D +G+++Y I DG G F + +G T LDRE + L + A
Sbjct: 1052 LVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFA 1111
Query: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887
D G LS+ + + + V D ND+AP P Y E+ E+ P ++Q++A DPD+ +N
Sbjct: 1112 TDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSN 1171
Query: 1888 GHVTYYLGAGTA-GAFLLEPSSGELRTAAA-LDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
+ Y + +G G F + P +G + T + LDREQ + V+ D + P ST
Sbjct: 1172 DKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP-PKSTIAR 1230
Query: 1946 VTITVRDVNDHAPTFPTSPLRLRLP---RPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
V + + D ND+ P F ++RLP +P + L + A D+D G NA I Y
Sbjct: 1231 VIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYS 1290
Query: 2003 LAGTPPPGTT-VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGE 2061
+ G ++ TG + R A G D +L I A D GRP +S+T + + +
Sbjct: 1291 IEDGNEHGKFFIEPKTGVVSSKRFSAA-GEYD-ILSIKAVDNGRPQKSSTTRLHIEWISK 1348
Query: 2062 AERGPR---FPRASSEATIRENAPP----GTPIVSPRAVHAGGTNGPITYSILSGNEKGT 2114
+ F + T+ E+ P G V P + P+ + I GN
Sbjct: 1349 PKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI-------PLWFDITGGNYDSH 1401
Query: 2115 FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRP 2174
F + TG I V A+ LD E L ++A G T + + + D ND+ P+F
Sbjct: 1402 FDVDKGTGTIIV--AKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTS 1459
Query: 2175 HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL--FHVDPTTGTITTT 2232
Y +PE E +LQ+ A +DQ ++ Y+L +S+ L F +DP TG++ T+
Sbjct: 1460 KYEVVIPEDTAPETEILQISA--VDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTS 1517
Query: 2233 AILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALL 2291
LD E + L +M D+ P A + V V DTND+ P ++ RV E A +
Sbjct: 1518 EKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAV 1577
Query: 2292 GSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQL 2349
GS + QVT D D G + Y + + F + G + LD Y L +
Sbjct: 1578 GSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMV 1637
Query: 2350 LAHDGPHEGRANLT---VLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
A D + +T + V ++ +P F+ Y V L E GS + V+A + S
Sbjct: 1638 KATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS- 1696
Query: 2407 ANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAA 2464
+ Y + + D F ++P++GT+ T AL + ++++ + G +
Sbjct: 1697 ----VVYEIKDGNTGDAFDINPHSGTIIT---QKALDFETLPIYTLIIQGTNMA--GLST 1747
Query: 2465 RATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-------LEATDADGSRSHAA 2517
TV V LQD+ND+AP F + Y ++E S +LT + A DAD S+A
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKD-SNAL 1806
Query: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADR 2577
+ Y I+ + F ++ + G + + LD+E + ++ TV D
Sbjct: 1807 LVYHIVEPSVHTYFAIDS--------------STGAIHTVLSLDYEETSIFHFTVQVHDM 1852
Query: 2578 GQPPQSS--VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHG 2635
G P + VTV V+D+ND PPVF + Y ++ T G +++ V A+DAD
Sbjct: 1853 GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFS 1912
Query: 2636 LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIE 2695
+ ++++ G+ F +D +G L + + + ++R++L V+A+D G L V I
Sbjct: 1913 QLIYSITEGNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASD--GRFAGLTSVKIN 1968
Query: 2696 VQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGR 2755
V++ + F ++ S V EN + + AI L Y +L P+ R
Sbjct: 1969 VKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINE--PLFYHILN----PDRR 2022
Query: 2756 EAFALNSSTGELRAR-VPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PV 2812
F ++ ++G L PFD E E+F ++V + SA V V V ED+ D PV
Sbjct: 2023 --FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPV 2080
Query: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGI 2861
F+ ++ V GH + +V A D D G +G V Y L +F I
Sbjct: 2081 FVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129
Score = 459 bits (1181), Expect = e-128
Identities = 481/1837 (26%), Positives = 779/1837 (42%), Gaps = 183/1837 (9%)
Query: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
SG + L + + + D RI + G L +RE + Y L+V+ + + +
Sbjct: 76 SGDSENLFKAEEYILGDFCFLRIRTKGGNTAIL---NREVKDHYTLIVKALEKNTNVEAR 132
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
T V V VLD ND P F S + + +P+ T + + A D D G NG
Sbjct: 133 T-KVRVQVLDTNDLRPLFSPTSYS------VSLPENTAIRTSIARVSATDADIGTNGEFY 185
Query: 1254 YTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQG-----SPPRSASLQLL 1308
Y+ +++F++HP SG ++ L E Y + + A D+G S S+ +L
Sbjct: 186 YSFKDR-TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLT 244
Query: 1309 VQV------LPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGV 1362
V + P P +RDPA ++TV + G + AG
Sbjct: 245 VHIEQANECAPVITAVTLSPSELDRDPAY---AIVTVDDCDQGANGDIASLSIV---AGD 298
Query: 1363 GALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAG--ARLL 1420
+ V + + A G +D+++ P LT++A+ G + +
Sbjct: 299 LLQQFRTVRSFPGSKEYKVKAIGG-------IDWDSHPFGYNLTLQAKDKGTPPQFSSVK 351
Query: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE 1480
+ V F +D + E P + +A A S +RY + +
Sbjct: 352 VIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA-----YSHLRY-VFKST 405
Query: 1481 PPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDEN 1540
P L+ TG +S + R+ L V +DR A+ V V N
Sbjct: 406 PGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTK--------VLVKVLGAN 457
Query: 1541 DNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTG 1599
N P F + + E+ P G + + A DPD GE V+Y +A+ F + TG
Sbjct: 458 SNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTG 517
Query: 1600 ALSVVRPLDREQRAE-HVLTVVASDHGSPPRSATQVL-TVSVADVNDEAPTFQQQEYSVL 1657
A+S LD E + L + ASD G P R +VL T+++ ++ND P F++
Sbjct: 518 AVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGT 577
Query: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTY-GGVSSESFSLDPDTGVLTTLRAL-----DR 1711
+ + G + T+ A D D Q G + FSL+P++GVL+ R+L +
Sbjct: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
Query: 1712 EEQEEINLTVYAQDRGSPPQLTHVTVRVA------------------------------- 1740
+ +T + + P ++TV +
Sbjct: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
Query: 1741 -VED-------ENDHAPTFGSA-HLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL 1790
VED N H P F S ++V E Q ++ + ++D D G NG+L Y +
Sbjct: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
Query: 1791 DGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDAND 1850
G+ F++D+ +G + PLDRE + L I D G P +A LL V V+DAND
Sbjct: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAND 817
Query: 1851 HAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE 1910
+ P F +Y VEV ED + ++Q++A D D G NGHVTY + T F ++ +G
Sbjct: 818 NPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGV 876
Query: 1911 LRTAAALDREQCPSYTFSVSAVDGAAAGP-LSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
+ A LDRE ++ + A D A P L +TV V +++ DVND+ PTF R+++
Sbjct: 877 VNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKV 936
Query: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVAL 2029
P + + L A D D G + + Y L VD +G +R+ +
Sbjct: 937 REDLPEGT----VIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFE 992
Query: 2030 GPRDRVLFIVATDLGRP-ARSATGVIIVGL--QGEAERGPRFPRASSEATIRENAPPGTP 2086
+ L + A D G+P + S+T + V + E P F + T++E+AP G+
Sbjct: 993 KKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSL 1052
Query: 2087 IVSPRAVHAGG-TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
+++ A +G I YSI G+ G F I TG I +++ LD E + L +
Sbjct: 1053 VMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVI--ETSDRLDRESTSHYWLTVF 1110
Query: 2146 AESGGAF---AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGS 2202
A G +F + + ++D NDNAP+ P Y + E+ P + ++Q+EA D D S
Sbjct: 1111 ATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS 1170
Query: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTA-ILDREIWAETRLVLMATDRGSPALVGSA 2261
++ Y + + P +G F + P TG ITTT+ LDRE E L + TD GSP A
Sbjct: 1171 NDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIA 1229
Query: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSE-------IAQVTGNDVDSGP--VLWY 2311
+ V ++D NDN+P Q +++R+ E E + V D D GP + Y
Sbjct: 1230 RVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISY 1289
Query: 2312 VLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ-LQLLAHDGPHEGRANLTVL-VEDV 2369
+ F + G VS F Y L + A D +++ T L +E +
Sbjct: 1290 SIEDGNEHGKFFIEPKTGVVS---SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWI 1346
Query: 2370 NDNAP-----AFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSV 2424
+ P +F +S + ++E P I +S G + F V
Sbjct: 1347 SKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV--EPPGIPLWFDITGGNYDSHFDV 1404
Query: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARAT-VHVQLQDQNDHAPSFT 2483
D G TI+ L + ++ +EA D G T V +++ D NDH P F+
Sbjct: 1405 DKGTG---TIIVAKPLDAEQKSNYNLTVEATD----GTTTILTQVFIKVIDTNDHRPQFS 1457
Query: 2484 LSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGES 2543
S Y V + ED P + +L + A D D S + F+L+P
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDP-------- 1509
Query: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT 2603
A G L E LD E++ Q+ LTV D+ P + + + V V D ND+ P FT
Sbjct: 1510 ------ATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFT 1563
Query: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAH 2663
+SY+ V E VG+ +L V A D D G + V +++ SG+ F +D G+++ A
Sbjct: 1564 ASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAK 1623
Query: 2664 ALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPG 2722
LD QA + L+V+A D + + V I V ++ P F S ++E G
Sbjct: 1624 ELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIG 1683
Query: 2723 TLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFR 2782
+ V + A + + Y + + G +AF +N +G + + D+E +
Sbjct: 1684 SFVGMV-----TAHSQSSVVYEIKDGNTG----DAFDINPHSGTIITQKALDFETLPIYT 1734
Query: 2783 LLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGAR--------RGHSLGH 2834
L++ + LS + TV V + E++ PVF+ + + E A R L
Sbjct: 1735 LIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL-V 1793
Query: 2835 VQATDEDGGADGLVLYSLATSS--PYFGINQTTGALY 2869
++A D D ++ L++Y + S YF I+ +TGA++
Sbjct: 1794 IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIH 1830
Score = 303 bits (777), Expect = 1e-81
Identities = 250/819 (30%), Positives = 379/819 (46%), Gaps = 46/819 (5%)
Query: 51 IDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
I E P G+ + I A +GT +MY + + V AI+ +G + T + LD
Sbjct: 2818 IVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDH 2877
Query: 110 EQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRY 162
E+RD Y+ V D +T V V V D+ND P F V E G
Sbjct: 2878 EKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVI 2937
Query: 163 PLEPARDADAGRLGTQ-GYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHY 221
+ DAD+ + Q Y ++G F +ET ++ V LDRE R +Y
Sbjct: 2938 AILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE-----WKVYVKKPLDREKRDNY 2992
Query: 222 MLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASD 281
+L + A DG ++A+++V +LD ND++P ++ Y + E + PG ++Q+ A+D
Sbjct: 2993 LLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATD 3049
Query: 282 ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP 341
AD N +TY + G F ++ TG L+ PLD E++ V+ L+V+A DGG
Sbjct: 3050 ADIRSNAEITYTL---LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG-- 3104
Query: 342 ELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHV 401
A + + + D NDN P F + + V E PG L+ R+ +D D G +
Sbjct: 3105 RFCQASIVLTLEDVNDNAPE----FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKI 3160
Query: 402 NVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSP-PLRAEAAFV 459
SL + +G F+++ +I L + LDRE + Y L + A D G P L A +
Sbjct: 3161 LYSLIDSADGQFSINELSGIIQL---EKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVI 3217
Query: 460 LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH 519
+ V D+NDN P F+ + Y + E L G+ V++V A D N ++TYS+ G
Sbjct: 3218 VSVLDINDNPPVFEYREY-GATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHG 3276
Query: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
FSID +G + +LDYE + L V ATDGG P L+ ATV+V + D+NDN P F
Sbjct: 3277 KFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
Query: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVC 639
+ Y + E + V A DAD + YS+ G+ GS F ID G+V
Sbjct: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIID--GNQGS-SFTIDPVRGEVK 3393
Query: 640 TTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQ 697
T+ LDR+ S + TV A D G + V + +SD NDN P F Y+ I
Sbjct: 3394 VTKLLDRET-ISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQEN 3452
Query: 698 SPPGTAVLRLRAHDPDQGSHG-RLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVV 756
P G +VL+L D D +G + I+ GN F ++ Q LLT + + R+
Sbjct: 3453 KPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTSS-AIKRKEKDHY 3511
Query: 757 QLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN 816
L++ D G Q +DI ++ + PP L+ + + G +G + A
Sbjct: 3512 LLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHA-T 3570
Query: 817 PPGRLAPVTLSLSGGDPR--GLFSLDAVSGLLQTLRPLD 853
+T SL DP+ LFS+ + G L + LD
Sbjct: 3571 DQDVYDTLTYSL---DPQMDNLFSVSSTGGKLIAHKKLD 3606
Score = 139 bits (349), Expect = 6e-32
Identities = 149/556 (26%), Positives = 239/556 (42%), Gaps = 51/556 (9%)
Query: 2334 TGPLDFEQCDRYQL--QLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391
T L+ E D Y L + L + E R + V V D ND P FS + Y V L E+T
Sbjct: 105 TAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAI 164
Query: 2392 GSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVV 2451
++I VSATD D G NG Y D F++ P +G IV T L + + ++
Sbjct: 165 RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG---VIVLTGRLDYLETKLYEME 221
Query: 2452 LEARD-----HGAPGRAARATVHVQLQDQNDHAP---SFTLSHYRVAVTEDLPPGSTLLT 2503
+ A D +G+ G ++ A + V ++ N+ AP + TLS + D P ++T
Sbjct: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSEL----DRDPAYAIVT 277
Query: 2504 LEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFE 2563
++ D D + SI++G+ + F+ + E +A+G +D++
Sbjct: 278 VD--DCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYK---VKAIG------GIDWD 326
Query: 2564 SLT-QYNLTVAAADRGQPPQ-SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAEL 2621
S YNLT+ A D+G PPQ SSV + VT P F + YR + E P +
Sbjct: 327 SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Query: 2622 LHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ V+A A + +R+ S F L+ ++G + + + + A +L V +D
Sbjct: 387 VMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD 442
Query: 2682 PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRL 2741
A V ++V N + P F + EN P GT V +L A+D D G G +
Sbjct: 443 ----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYV 498
Query: 2742 RYSLLEAGPGPEGREAFALNSSTGELRARVPFDYE-HTESFRLLVGAADAG---NLSASV 2797
YS+ P FA++ TG + DYE + L + A+D G V
Sbjct: 499 TYSIANLNHVP-----FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553
Query: 2798 TVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS- 2856
++ + ++ P+F +P G + V A D D LV Y + +
Sbjct: 554 LATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNE 611
Query: 2857 -PYFGINQTTGALYLR 2871
+F +N +G L L+
Sbjct: 612 LDFFSLNPNSGVLSLK 627
Score = 67.0 bits (162), Expect = 3e-10
Identities = 70/270 (25%), Positives = 110/270 (40%), Gaps = 27/270 (10%)
Query: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLH-VEASDADPGPHGLVRFTVSSGDPSGLFELD 2653
+ P FT Y VTV E++ + H V+ P VR+ + SGD LF+ +
Sbjct: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
Query: 2654 E----SSGTLRL------AHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHG 2703
E LR+ L+ E + + L+V+A + A V ++V D ND
Sbjct: 87 EYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLR 146
Query: 2704 PAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSS 2763
P F S S+ EN T + + A D D G G YS + + FA++ +
Sbjct: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF------KDRTDMFAIHPT 200
Query: 2764 TGELRARVPFDYEHTESFRLLVGAADAG-------NLSASVTVSVLVTGEDEYDPVFLAP 2816
+G + DY T+ + + + AAD G +S+ ++V + +E PV A
Sbjct: 201 SGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAV 260
Query: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADG 2846
P R + V D D GA+G
Sbjct: 261 TLS---PSELDRDPAYAIVTVDDCDQGANG 287
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 880 bits (2275), Expect = 0.0
Identities = 814/2881 (28%), Positives = 1304/2881 (45%), Gaps = 215/2881 (7%)
Query: 48 DLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 106
D+ + E+ P G I I A +G +++ IS + ID +G ++
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMP 788
Query: 107 LDREQRDRYRFTAVTPDGATVE------VTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
+DRE D Y D + +T+ V D ND++P F Q ++ + E + GT
Sbjct: 789 MDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
Query: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
ARD D G G Y++ D + F + + G + V +LDRE++++
Sbjct: 849 EIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGI-------VYVADQLDRESKAN 899
Query: 221 YMLQLEAYDGGSPPRRAQAL--LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVF 278
Y L++EA D ++ ++ L V L D+ND +PAF S Y V E L G+ + +
Sbjct: 900 YSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLE 959
Query: 279 ASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGG 338
D D G+ G V Y + ++ +G F ID +G ++L + LD+E+++ + L V+A+D G
Sbjct: 960 THDPDLGLGGQVRYSL---VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKG 1016
Query: 339 AHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGD 397
L S +FV V V D N+N + + GS V E + G V +++ D D G
Sbjct: 1017 RPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS--VKENSRIGTSVLQVTARDEDSGR 1074
Query: 398 FAHVNVSLEGGEG--HFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
+ S+ G G F++ + VI A LDRE +Y L V ATD G PL +
Sbjct: 1075 DGEIQYSIRDGSGLGRFSIDDESGVI---TAADILDRETMGSYWLTVYATDRGVVPLYST 1131
Query: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPG 515
+ V DVNDNAP +Y P + S V+++ A DPD +N ++TY + G
Sbjct: 1132 IEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVS-VIQIQAEDPDSSSNEKLTYRITSG 1190
Query: 516 AHTHWFSIDPTSGIITTAA-SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDN 574
++F+I+ +G+ITT + LD E + + L V TDGG P S+ V V + D NDN
Sbjct: 1191 NPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
Query: 575 EPQFQRTFYNASLPEGTQP--GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRID 632
+PQF Y LPE + G + A D D GP +SYS+ G + F ID
Sbjct: 1251 KPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDG---NDDGKFFID 1307
Query: 633 AHSGDVCTTRTLDRDQGPSSFDF-TVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYA 691
+G V + + S+D T+ AVD G + ++ + PP P +
Sbjct: 1308 PKTGMVSSRKQFTA----GSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFD 1363
Query: 692 ASIS----AQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWP 747
+S T ++ + + P ++ L + I+ GN F ++ G + +A P
Sbjct: 1364 EPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP 1420
Query: 748 LARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGT 807
L S+ + + DG + +V I ++ P F Q Y ++ EDV P T
Sbjct: 1421 LDAEQRSIYNMSVEVTDGTNVAV---TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDT 1477
Query: 808 SVGIVQA--HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELE 864
+ ++A + +L+ S F +D +G+L T LD E +L +
Sbjct: 1478 EILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIM 1537
Query: 865 VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSG 924
VR P +ARV V ++D ND+SP F P + + A G+ + + ALD D G
Sbjct: 1538 VR-DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKG 1596
Query: 925 VNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR--TSH 981
N+ + +T+ AG G F ++P G + + + + L ++ D GSPP T+
Sbjct: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
Query: 982 FRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGA 1041
R+ V + D P+F Y+ ++ GT V+ + A + + Y +
Sbjct: 1657 VRISVTMSD----NSHPKFIHKDYQAEVNENVDIGTSVILISAISQS--TLIYEVKDGDI 1710
Query: 1042 SSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101
+ F + P SG + + ALD E Y L + A + + ATV + I+++N++
Sbjct: 1711 NGIFTINPYSGVITTQKALDYERTSSYQLIIQATN-----MAGMASNATVNIQIVDENDN 1765
Query: 1102 SPRLSEDPTFLAVAENQPPGTSVGR-------VFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
+P +++E P + V + ATD DS N L Y + + S K F
Sbjct: 1766 APVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVE-STAKKFF 1824
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV--AVLDLNDNSPTFL 1212
+ TG + T+ LD E + + V V+D GSP + V V V D+NDN P F
Sbjct: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFT 1884
Query: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGE 1272
QA LP V G V + A DPD + Y+L + F + +SG
Sbjct: 1885 QAVFETILLLPTYV------GVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGV 1938
Query: 1273 LLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSA-RLAEPPPDLAERDPAA 1331
L + + HY+L + D S ++ + + S + + +
Sbjct: 1939 LTIKNNNL--SKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNT 1996
Query: 1332 PVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLA 1391
+ V V A G+ L EP L Y+++ +P F + + SG +
Sbjct: 1997 NITKVAIVNAV-----GNRLN-----EP-----LKYSIL---NPGNKFKIKSTSGVIQTT 2038
Query: 1392 R-PLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPE 1450
P D E + + + + V+V ++D N+++P F P A+ + E
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
Query: 1451 PGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTP--- 1507
PG +Y A D D GPN +V Y L + ++ +G + + + +
Sbjct: 2099 PGTLIYQVTAIDKD-KGPNGEVTYVL---QDDYGHFEINPNSGNVILKEAFNSDLSNIEY 2154
Query: 1508 ALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALH 1566
+ +L + +P+ ++ S + +T N PVF P + ED L
Sbjct: 2155 GVTILAKDGGKPSLST-------SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILS 2207
Query: 1567 VVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
+ A P E + Y + G F + TG L VV PLD E + + LT+ ASD
Sbjct: 2208 INATSP---EGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDAL 2264
Query: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVT 1685
+ R+ V + V DVND P F Q Y+ L E + GT +L + + D D N V
Sbjct: 2265 TGARAEVTV-DLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVH 2323
Query: 1686 YGGV-----SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
Y V S++ F +D +G++ T R LD E + L V + D G P + V V +
Sbjct: 2324 YQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
Query: 1741 VEDENDHAPTFGS----AHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSG 1796
+ D ND+ P F +++S P G +T ++ASD D +L+Y IL G+
Sbjct: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGH---FVTCVQASDADSSDFDRLEYSILSGNDRT 2440
Query: 1797 AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
+F++D SG + +EP + L + DG ++T + + VL AN ++PAF
Sbjct: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFS 2497
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAA 1916
Y EV E+V AGT ++ ++A D D G G ++Y + A L S+G++ T
Sbjct: 2498 QSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTER 2557
Query: 1917 LDREQCPSYTFS--VSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 1974
LDRE S V A+DG G +T +V + V D ND+AP F T R +
Sbjct: 2558 LDRENPLEGDVSIFVRALDG---GGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
Query: 1975 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSYTGEIRVARSPVALG 2030
T ++A D D GAN+ I Y L +D G + + L
Sbjct: 2615 RGHLVT----QVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLK 2670
Query: 2031 PRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSP 2090
F+ A D G P + + + + + P F ++ TI E+ G+ + +
Sbjct: 2671 NTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTL 2730
Query: 2091 RAVHAGGTNGPITYSILSG-----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
R + + + +S ++G N+ G F I+ TG T++ + LD E SP +
Sbjct: 2731 RILPSQN----VWFSTVNGERPENNKGGIFVIEQETG--TIKLDKRLDRETSPAFHFKVA 2784
Query: 2146 AE---SGGAFAFTV-LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQG 2201
A FTV + + + D NDN P F Y + E P+ L QV A D+D G
Sbjct: 2785 ATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG 2844
Query: 2202 SGGQISYSLAA-SQPARGL--FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-AL 2257
+ GQ++YSL + SQP + + F++D TG I+T LD E ++A+D G +L
Sbjct: 2845 ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSL 2904
Query: 2258 VGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPV---LWYVL 2313
+A ++V V D NDN P Q + V E G +A ++ D D+ V + Y +
Sbjct: 2905 SSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964
Query: 2314 SPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVND 2371
+ P+ F++G +V + PLD E+ D Y L + A DG +A + V V DVND
Sbjct: 2965 TGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVND 3024
Query: 2372 NAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-FSVDPNNGT 2430
N+P Q Y +L E P IL VSA D D G+NG+I Y L + F +DP +G
Sbjct: 3025 NSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGE 3084
Query: 2431 LFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVA 2490
L T+ L + ++ +A D G GR ++ +H+ L+D ND+ P F+ HY
Sbjct: 3085 LKTLA---LLDRERIPVYSLMAKATDGG--GRFCQSNIHLILEDVNDNPPVFSSDHYNTC 3139
Query: 2491 VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA 2550
V E+ + L ++A D D + V YS+ + + G VF ++ +
Sbjct: 3140 VYENTATKALLTRVQAVDPDIGINRKVV-YSL-ADSAGGVFSIDS--------------S 3183
Query: 2551 LGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS--SVVPVTVTVLDVNDNPPVFTRASYR 2608
G ++L +PLD E + YN++V A D+ P QS S+ VT+TVLD+NDNPPVF R Y
Sbjct: 3184 SGIIILEQPLDREQQSSYNISVRATDQS-PGQSLSSLTTVTITVLDINDNPPVFERRDYL 3242
Query: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCE 2668
VTVPEDT G ++L V A+ D G + + + + SG+ G F+++ +G + ++ LD E
Sbjct: 3243 VTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYE 3302
Query: 2669 TQARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT 2727
R LVV+A D A A+A V I + DVND+ P F ++ S ++E+ G V
Sbjct: 3303 LCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVIL 3362
Query: 2728 LHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGA 2787
L A D D+ G++ +S++ E F ++ G ++ + D E + LLV A
Sbjct: 3363 LIAEDVDSQPNGQIHFSIVNGDRDNE----FTVDPVLGLVKVKKKLDRERVSGYSLLVQA 3418
Query: 2788 ADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGAD 2845
D+G +S++ TV++ ++ ++ PVF + + E G S+ + TD D +
Sbjct: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
Query: 2846 G 2846
G
Sbjct: 3479 G 3479
Score = 773 bits (1995), Expect = 0.0
Identities = 771/2793 (27%), Positives = 1226/2793 (43%), Gaps = 206/2793 (7%)
Query: 136 INDHAPAFPQARAA-LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
IN P F ++ + + V E G A DAD+G G + +S F ++
Sbjct: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
Query: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
G +L V +DRE+ Y+L + YD G+P + + LL + + D ND++P
Sbjct: 778 METG-------QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
Query: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
F Q Y + ES G+ ++QV A D D G NG VTY + + F+I++ TG++
Sbjct: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ----FAINSSTGIV 886
Query: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHV--RDANDNQPSMTVIFLSADGS 372
+ LD E + + L ++ARD + + VT+ V D ND P+ F+ + S
Sbjct: 887 YVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA----FIPSSYS 942
Query: 373 PQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG-EGHFALSTQDSVIYLVCVARRLD 431
+V E P G ++A + DPD G V SL G F + I L ++ LD
Sbjct: 943 VKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRL---SKELD 999
Query: 432 REERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
E++ YNL V A D G P + +FV + V DVN+N L+ P P+ A+ GS
Sbjct: 1000 YEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN-------LHTPY-FPDFAVVGS 1051
Query: 491 F---------VVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELE 541
V++VTARD D G +G++ YS+ G+ FSID SG+IT A LD E
Sbjct: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM 1111
Query: 542 PQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
L V ATD G+ PL S+ V + ++DVNDN P Y + E + +Q+
Sbjct: 1112 GSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQ 1171
Query: 602 ATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTT-RTLDRDQGPSSFDFTVT 658
A D DS L+Y + +SG+P F I+ +G + TT R LDR+Q F VT
Sbjct: 1172 AEDPDSSSNEKLTYRI-----TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF-LEVT 1225
Query: 659 AVDGGGL--KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPP--GTAVLRLRAHDPDQ 714
DGG +S ++V V + DENDN PQF + Y + + G + R A D D+
Sbjct: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
Query: 715 GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSA 774
G + +SY I+ GN F +D ++G+++ A S L I A D G Q +A
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFT--AGSYDILTIKAVDNGRPQKSSTA 1343
Query: 775 RVDISIV---PGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGG 831
R+ I + P +P P F++ Y F+V E VG+V P P+ + GG
Sbjct: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQ--PAN-TPLWFDIVGG 1400
Query: 832 DPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
+ F + G + +PLD E + +EV G+ V AV +V + + D NDN
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV----AVTQVFIKVLDNNDN 1456
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA----FTVDPT 946
P F P V + + P T I + A D D ++++T+ + F +DP+
Sbjct: 1457 GPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPS 1514
Query: 947 TGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYR 1006
TG + L H L + RD P R + R+ V V+D +P F +P Y
Sbjct: 1515 TGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDH--SPYFTNPLYE 1572
Query: 1007 VDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDRE 1063
+ G+ VLQV A D G + Y + A + F +EP G + + D
Sbjct: 1573 ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMT 1632
Query: 1064 AQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTS 1123
++L + + + TA VR+S+ + P+ V EN GTS
Sbjct: 1633 TMGQFVLSIKVTDQGSPPM---SATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTS 1689
Query: 1124 VGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQV 1183
V + A + + L Y ++ + + F I+P +G +TT + LD E+ SSYQL++Q
Sbjct: 1690 VILISAISQST-----LIYEVKD-GDINGIFTINPYSGVITTQKALDYERTSSYQLIIQA 1743
Query: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFL--QASGAAGGGLPIQVPDRVPPGTLVTTLQA 1241
+ ++ TV++ ++D NDN+P FL Q SG+ PI R + + ++A
Sbjct: 1744 TNMAG--MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLV-IRA 1800
Query: 1242 KDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPP 1300
D D N ++Y + + F++ +G + T A L H+ + D GSP
Sbjct: 1801 TDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
Query: 1301 RSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPA 1360
+A + V + + + PP + A +L + G+ L S P+
Sbjct: 1861 LTAESPVEVNI-EVTDVNDNPPVFTQ----AVFETILLLPTYVGVEV--LKVSATDPDSE 1913
Query: 1361 GVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLL 1420
LTY+L+ G+ F +D+ SG L + L V+ G
Sbjct: 1914 VPPELTYSLMEGSLDH--FLIDSNSGVLTIKNN---NLSKDHYMLIVKVSD--GKFYSTS 1966
Query: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE 1480
V + V++ + F + + ++ EN + +A G N ++Y +L
Sbjct: 1967 MVTIMVKEAMDSGLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRLNEPLKYSILN-- 2021
Query: 1481 PPVPALRLDARTGALSAPR-GLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
P ++ + +G + DRE L+VEA+ R ARV RV + D
Sbjct: 2022 -PGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS---RELDHLRVARVVVRVNIEDI 2077
Query: 1540 NDNAPVFAS-PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSST 1598
NDN+PVF P + D PG V A D D G V+Y L GHF ++ ++
Sbjct: 2078 NDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDY-GHFEINPNS 2136
Query: 1599 GALSVVRPLDRE-QRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL 1657
G + + + + E+ +T++A D G P S + L +++ VN P F + Y+
Sbjct: 2137 GNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTAS 2194
Query: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEI 1717
+ E+ T +L++ AT P+ + G + F++D DTGVL + LD E
Sbjct: 2195 VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
Query: 1718 NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRAS-D 1776
LT+ A D + + VTV + V D ND+ P F + + E T + S D
Sbjct: 2255 KLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSID 2313
Query: 1777 PDVGANGQLQYRILDG--DPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
D N + Y+I+ + + F +D +SG T R LD E+ L++ + D G P+
Sbjct: 2314 ADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPS 2373
Query: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
LS+ +L+ + + D ND+ P F Y V E P G + +QA D D+ + Y +
Sbjct: 2374 LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
Query: 1895 GAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
+G +FL++ SG + + + P Y+ +VS DG ++T V I V
Sbjct: 2434 LSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL----FTSTAQVHIRVLGA 2489
Query: 1954 NDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
N ++P F S + R + T + + RA D D G I Y + +
Sbjct: 2490 NLYSPAFSQSTYVAEV-RENVAAGTKVIHV---RATDGDPGTYGQISYAIINDFAKDRFL 2545
Query: 2014 DSYTGEI----RVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFP 2069
G++ R+ R G D +F+ A D G T +IV E + P+F
Sbjct: 2546 IDSNGQVITTERLDRENPLEG--DVSIFVRALDGGGRTTFCTVRVIV--VDENDNAPQFM 2601
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGT---FSIQPSTGAIT 2125
A++R + G + +A+ G N ITYS+ S I P G +
Sbjct: 2602 TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMV 2661
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPE 2182
+ + + L ++A GG + + + + P F + Y + E
Sbjct: 2662 TKG--NFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAE 2719
Query: 2183 SRPLEGPLLQVEADDLDQGSGGQISYSLAASQPAR----GLFHVDPTTGTITTTAILDRE 2238
+ + D L + +S + G+F ++ TGTI LDRE
Sbjct: 2720 DTAIGSTV-----DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRE 2774
Query: 2239 IWAETRLVLMAT-DRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIA 2296
+ AT +V + + + V+D NDN+P ++ + E +G+++
Sbjct: 2775 TSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT 2834
Query: 2297 QVTGNDVD---SGPVLWYVLSPSGPQ---DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350
QV D+D +G V + + S S P+ + F++ G +S LD E + ++
Sbjct: 2835 QVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV 2894
Query: 2351 AHDGPH----EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD-S 2405
A D A ++V V D+NDNAP F+Q +Y+ + E PPG + +S DRD S
Sbjct: 2895 ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTS 2954
Query: 2406 GANGHISYHLA--SPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRA 2463
N +SYH+ +P F++ V L + + + A D
Sbjct: 2955 DVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR-PLDREEQDIYFLNITATDGLF---V 3010
Query: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
+A V V + D ND++P Y + ED+P +L + A DAD S+ + YS+
Sbjct: 3011 TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIG-SNGYIRYSLY 3069
Query: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS 2583
G+ F L+P E+GE L L LD E + Y+L A D G
Sbjct: 3070 -GSGNSEFFLDP---ESGE-----------LKTLALLDRERIPVYSLMAKATDGGGRFCQ 3114
Query: 2584 SVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS 2643
S + + + DVNDNPPVF+ Y V E+T A L V+A D D G + V ++++
Sbjct: 3115 SNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
Query: 2644 GDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD--PAGAHFALAPVTIEVQDVND 2701
G+F +D SSG + L LD E Q+ + + V+A D P + +L VTI V D+ND
Sbjct: 3173 S-AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIND 3231
Query: 2702 HGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALN 2761
+ P F +V E+ PGT V + A D G + Y L+ +G +G+ F +N
Sbjct: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY-LIRSG-NEQGK--FKIN 3287
Query: 2762 SSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFH 2819
TG + DYE + F L+V A D G LSA TV++ +T ++ P F +
Sbjct: 3288 PKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYS 3347
Query: 2820 FQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
+ E A G S+ + A D D +G + +S+
Sbjct: 3348 AVISEDALVGDSVILLIAEDVDSQPNGQIHFSI 3380
Score = 761 bits (1966), Expect = 0.0
Identities = 792/2963 (26%), Positives = 1281/2963 (43%), Gaps = 289/2963 (9%)
Query: 48 DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 106
D ++E P GT + +SA G + Y I++ I++ +GV+ T
Sbjct: 478 DAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNL----LPFVINQFTGVISTTEE 533
Query: 107 LDREQRDR-YRFTAVTPDGAT-------VEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
LD E YRF D + V VT+R+ ++ND++P F + +
Sbjct: 534 LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPV 593
Query: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
G A D D L + +SG+ G + PD + V +L +
Sbjct: 594 GGHITAVSAIDIDELEL-VKYKIISGNELGFFYL-----NPD-SGVLQLKKSLTNSGIKN 646
Query: 219 SHYMLQLEAYDGGS------------------------PPRRAQALLDVTLL-------- 246
++ L++ A DG + R AQ L + L+
Sbjct: 647 GNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706
Query: 247 ----------DINDHAPAFNQSRYHAV-VSESLAPGSPVLQVFASDADAGVNGAVTYEIN 295
IN P F++S V V E L G+ +L++ A DAD+G NG V + I+
Sbjct: 707 NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766
Query: 296 RRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355
D F+ID TG L++ P+D E ++ L + D G + +T++V DA
Sbjct: 767 --DGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDA 824
Query: 356 NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALS 415
NDN P +F+ S + E++ G + ++ D D G V S+ FA++
Sbjct: 825 NDNSP----VFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAIN 880
Query: 416 TQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHV--TDVNDNAPAFD 473
+ ++Y VA +LDRE + Y+L++ A D + + L V DVND +PAF
Sbjct: 881 SSTGIVY---VADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
Query: 474 RQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTA 533
Y + L ++ + G+ + + DPD G GQV YSL + F ID SG I +
Sbjct: 938 PSSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLS 995
Query: 534 ASLDYELEPQPQLIVVATDGGLP-PLASSATVSVALQDVNDN--EPQFQRTFYNASLPEG 590
LDYE + L V A D G P L+S + V V + DVN+N P F S+ E
Sbjct: 996 KELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055
Query: 591 TQPGTCFLQVTATDADSGPFGLLSYSL--GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQ 648
++ GT LQVTA D DSG G + YS+ G+GLG F ID SG + LDR+
Sbjct: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR-----FSIDDESGVITAADILDRET 1110
Query: 649 GPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLR 706
S+ TV A D G L S + V + + D NDN P Y + SP +V++
Sbjct: 1111 -MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169
Query: 707 LRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV-AWPLARRANSVVQLEIGAEDG 765
++A DPD S+ +L+Y I +GN F ++ ++GL+T + L R + LE+ DG
Sbjct: 1170 IQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDG 1229
Query: 766 GGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAH---NPPGRLA 822
G + + V + ++ P F + Y +PE I +A G A
Sbjct: 1230 GPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNA 1289
Query: 823 PVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRA-GSGVPPAFAVARVR 881
++ S+ G+ G F +D +G++ + + G L ++A +G P + AR+
Sbjct: 1290 EISYSIVDGNDDGKFFIDPKTGMVSSRKQFTA---GSYDILTIKAVDNGRPQKSSTARLH 1346
Query: 882 VLLDDVNDNSPAFPAPEDTVLLPPNTAPGT---PIYTLRALDPDS-----GV------NS 927
+ E PP+ P T P Y ++ D GV N+
Sbjct: 1347 I---------------EWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
Query: 928 RVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRV 986
+ F ++ G AF + G + + +PL + + +E DG + T F +
Sbjct: 1392 PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVF---I 1448
Query: 987 VVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASS 1043
V D G P F+ P Y V + T++LQ++A D T H + + S
Sbjct: 1449 KVLDNNDNG--PEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM 1506
Query: 1044 -PFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHS 1102
F ++P +G L+ LD EAQ+ +IL +M E + A V V++ + N+HS
Sbjct: 1507 RKFRIDPSTGVLYTAERLDHEAQDKHILNIMV---RDQEFPYRRNLARVIVNVEDANDHS 1563
Query: 1103 PRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGE 1162
P + +V E+ G++V +V A D+D G N L Y+++ F+I P G
Sbjct: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA-GNTGNMFKIEPVLGI 1622
Query: 1163 VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGL 1222
+T + D + L ++V D GSPP S T V ++V +++ P F+ A
Sbjct: 1623 ITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQA---- 1678
Query: 1223 PIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIR 1281
+V + V GT V + A T++Y + G + +F+++P+SG + T L
Sbjct: 1679 --EVNENVDIGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDY 1731
Query: 1282 AERPHYVLTLSAHDQGSPPRSASLQLLV----QVLPSARLAEPPPDLAERDPAAPV---- 1333
Y L + A + +A++ + + P ++ L+E P +
Sbjct: 1732 ERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSL 1791
Query: 1334 ---PVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYL 1390
P+V+ T A+ R L+ + + + F +D+++G +
Sbjct: 1792 DNSPLVIRATDADSNRNALLVYQIVE----------------STAKKFFTVDSSTGAIRT 1835
Query: 1391 ARPLDFEAGPPWRA-LTVRAEG-PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPEN 1448
LD E + + VR G P + V ++V D N++ P F + L
Sbjct: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP 1895
Query: 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPA 1508
G + A+D D P ++ Y L+ E + +D+ +G L+ + +
Sbjct: 1896 TYVGVEVLKVSATDPDSEVP-PELTYSLM--EGSLDHFLIDSNSGVLTIKN--NNLSKDH 1950
Query: 1509 LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAALHV 1567
+L+V+ +D ++ + V + D+ F S + E+ V
Sbjct: 1951 YMLIVKVSDGKFYSTSM------VTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIV 2004
Query: 1568 VARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVR-PLDREQRAEHVLTVVASDHGS 1626
A L E + Y + + G+ F++ S++G + P DRE++ + L V AS
Sbjct: 2005 NAVGNRLNEPLK--YSILNPGN-KFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELD 2061
Query: 1627 PPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY 1686
R A V+ V++ D+ND +P F Y ++ + PGT + + A D D G NG+VTY
Sbjct: 2062 HLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY 2121
Query: 1687 GGVSSES-FSLDPDTGVLTTLRALDREEQE-EINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
F ++P++G + A + + E +T+ A+D G P T V + + +
Sbjct: 2122 VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV-- 2179
Query: 1745 NDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQ-LQYRILDGDPSGAFVLDL 1802
N P F + V E T + + A+ P+ GQ + Y I+DGDP F +D
Sbjct: 2180 NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE----GQGIIYIIIDGDPFKQFNIDF 2235
Query: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV 1862
+G + PLD EV A++L I A D A A + + + V D ND+ P F P Y+
Sbjct: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGA-RAEVTVDLLVNDVNDNPPIFDQPTYNT 2294
Query: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA---FLLEPSSGELRTAAALDR 1919
+ E GT +LQ+ + D D+ N V Y + T + F ++ SSG + TA LD
Sbjct: 2295 TLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDH 2354
Query: 1920 EQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTP 1979
E T V ++D LS+ V V I + DVND+ P F + P
Sbjct: 2355 ELVQHCTLKVRSIDSGFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
Query: 1980 TLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFI 2038
T ++A D D+ + Y L+G +DS +G I ++ R L+
Sbjct: 2414 TC----VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQ---RMEPLYS 2466
Query: 2039 VATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-G 2097
+ + ++T + + + G P F +++ A +REN GT ++ RA G
Sbjct: 2467 LNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPG 2526
Query: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEG---LDFEVSPRLRLVLQAESGGAFAF 2154
T G I+Y+I++ K F I + IT + L+ +VS +R + + GG F
Sbjct: 2527 TYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRAL---DGGGRTTF 2583
Query: 2155 TVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSL--AA 2212
+ + + D NDNAP+F+ Y A + + QV+A D D G+ +I+YSL A
Sbjct: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEA 2643
Query: 2213 SQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
S L +DP G + T ++ + A D G P + + V+
Sbjct: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703
Query: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDP----FSVGRY 2327
P+ Q + ++ED +GS + T + S V + ++ P++ F + +
Sbjct: 2704 FLPSFTQSQYSFTIAEDTAIGSTVD--TLRILPSQNVWFSTVNGERPENNKGGIFVIEQE 2761
Query: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVE----DVNDNAPAFSQSLYQV 2383
G + L LD E + ++ A + TV V+ D+NDN P F S Y
Sbjct: 2762 TGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDT 2821
Query: 2384 MLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA------DGFSVDPNNGTLFTIVGT 2437
+++E P G+ + V A D D GANG ++Y L S + + F++D N G + T+
Sbjct: 2822 IIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD- 2880
Query: 2438 VALGHDGSGAVDVVLEARDHG-APGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLP 2496
L H+ + A D G A ++ A V V++ D ND+AP F YR V E P
Sbjct: 2881 --LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 2497 PGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL-- 2554
PG + L D D S + V Y I GN PR G ALG +
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGN--------PR----------GRFALGLVQS 2980
Query: 2555 ----VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVT 2610
+ PLD E Y L + A D Q+ V V+V DVNDN PV + +Y
Sbjct: 2981 EWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMV---EVSVSDVNDNSPVCDQVAYTAL 3037
Query: 2611 VPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2670
+PED P +L V A DAD G +G +R+++ S F LD SG L+ LD E
Sbjct: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERI 3096
Query: 2671 ARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHA 2730
+ L+ +A D G F + + + ++DVND+ P F + +T V EN L+T + A
Sbjct: 3097 PVYSLMAKATD-GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQA 3155
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G ++ YSL ++ G F+++SS+G + P D E S+ + V A D
Sbjct: 3156 VDPDIGINRKVVYSLADSAGG-----VFSIDSSSGIIILEQPLDREQQSSYNISVRATDQ 3210
Query: 2791 G---NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGL 2847
+LS+ TV++ V ++ PVF + VPE G + V AT +D G +
Sbjct: 3211 SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAE 3270
Query: 2848 VLYSLATSSPY--FGINQTTGAL 2868
+ Y + + + F IN TG +
Sbjct: 3271 ITYLIRSGNEQGKFKINPKTGGI 3293
Score = 731 bits (1886), Expect = 0.0
Identities = 732/2687 (27%), Positives = 1193/2687 (44%), Gaps = 197/2687 (7%)
Query: 51 IDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
+ E GT + ++A +G + Y S ++GSG+G +ID+ SGV+ A +LDR
Sbjct: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQY--SIRDGSGLGR-FSIDDESGVITAADILDR 1108
Query: 110 EQRDRYRFTA------VTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYP 163
E Y T V P +T+EV + V D+ND+AP + V E++
Sbjct: 1109 ETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Query: 164 LEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYML 223
A D D+ Y ++ F + + G T + +LDRE ++ + L
Sbjct: 1169 QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITT------TSRKLDREQQAEHFL 1222
Query: 224 QLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSES--LAPGSPVLQVFASD 281
++ DGG P+++ + V +LD ND+ P F + Y + E G P+ + FA D
Sbjct: 1223 EVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282
Query: 282 ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP 341
D G N ++Y I DG F ID TG++ + F L ++A D G
Sbjct: 1283 RDEGPNAEISYSIV--DGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRPQ 1338
Query: 342 ELGSAFVTVHVRDANDNQPS-MTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAH 400
+ +A +H+ PS + + F + V E+ ++V +SV +
Sbjct: 1339 KSSTA--RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPAN----TP 1392
Query: 401 VNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVL 460
+ + GG A + V +V +A+ LD E+R YN+ V TD + A +
Sbjct: 1393 LWFDIVGGNFDSAFDAEKGVGTIV-IAKPLDAEQRSIYNMSVEVTDGTNV---AVTQVFI 1448
Query: 461 HVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT-YSLAPGAHTH 519
V D NDN P F + Y + E LP + ++++ A D D+ T +S
Sbjct: 1449 KVLDNNDNGPEFSQPNY-DVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMR 1507
Query: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
F IDP++G++ TA LD+E + + L ++ D P + A V V ++D ND+ P F
Sbjct: 1508 KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567
Query: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVC 639
Y AS+ E G+ LQVTA D D G L Y++ AG ++G+ F+I+ G +
Sbjct: 1568 NPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAG--NTGNM-FKIEPVLGIIT 1624
Query: 640 TTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQ 697
+ D F ++ D G + + V++ ++ +++ P+F ++Y A ++
Sbjct: 1625 ICKEPDMTT-MGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNEN 1683
Query: 698 SPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQ 757
GT+V+ + A S L Y + G+ +FT++ SG++T L S Q
Sbjct: 1684 VDIGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQ 1738
Query: 758 LEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP 817
L I A + G+ + +A V+I IV P+F QY S+ E AP S+ + N
Sbjct: 1739 LIIQATNMAGMAS--NATVNIQIVDENDNAPVFLFSQYSGSLSE-AAPINSI-VRSLDNS 1794
Query: 818 P----------GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVR 866
P R A + + + F++D+ +G ++T+ LD E + + VR
Sbjct: 1795 PLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVR 1854
Query: 867 AGSGVPPAFAVARVRVLLD--DVNDNSPAFP-APEDTVLLPPNTAPGTPIYTLRALDPDS 923
SG P A + V V ++ DVNDN P F A +T+LL P T G + + A DPDS
Sbjct: 1855 -DSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP-TYVGVEVLKVSATDPDS 1912
Query: 924 GVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFR 983
V +T++L+ G F +D +G + + + H + + G TS
Sbjct: 1913 EVPPELTYSLMEGSLDHFLIDSNSGVLTIKNN---NLSKDHYMLIVKVSDGKFYSTS--M 1967
Query: 984 LRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLAAEGAS 1042
+ ++V++ GL F Y + T T+V V A P+ Y + G
Sbjct: 1968 VTIMVKEAMDSGL--HFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPG-- 2023
Query: 1043 SPFGLEPQSGWLWVRAA-LDREAQELYILKVMAVSGSKAELGQ-QTGTATVRVSILNQNE 1100
+ F ++ SG + DRE QELY L V A EL + VRV+I + N+
Sbjct: 2024 NKFKIKSTSGVIQTTGVPFDREEQELYELVVEA----SRELDHLRVARVVVRVNIEDIND 2079
Query: 1101 HSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQT 1160
+SP P + AV + PGT + +V A D+D GPNG +TY LQ +D F I+P +
Sbjct: 2080 NSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNS 2136
Query: 1161 GEVTTLQTLDREQQS-SYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1219
G V + + + + Y + + +DGG P ST+ V + + +N P F + A
Sbjct: 2137 GNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTS--VELPITIVNKAMPVFDKPFYTAS 2194
Query: 1220 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPL 1279
V + + T + ++ A P EG+ G I + G + F++ +G L +PL
Sbjct: 2195 ------VNEDIRMNTPILSINATSP-EGQ-GIIYIIIDGDPFKQFNIDFDTGVLKVVSPL 2246
Query: 1280 IRAERPHYVLTLSAHDQGSPPRS-ASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLT 1338
Y LT+ A D + R+ ++ LLV D+ + P P T
Sbjct: 2247 DYEVTSAYKLTIRASDALTGARAEVTVDLLVN------------DVNDNPPIFDQPTYNT 2294
Query: 1339 VTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT--FALDAASGRLYLARPLDF 1396
+ L +L V+ + + + + T F +D++SG + AR LD
Sbjct: 2295 TLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDH 2354
Query: 1397 EAGPPWRALTVRAEGPGGAG-ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAAL 1455
E L VR+ G + + V + + D N++ P F + + E G +
Sbjct: 2355 ELVQHC-TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
Query: 1456 YTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEA 1515
+ASDAD + + Y +L L +D+++G ++ + P L V
Sbjct: 2414 TCVQASDADSSDFDR-LEYSILSGNDRTSFL-MDSKSGVITLSNHRKQRMEPLYSLNVSV 2471
Query: 1516 TDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVARDPDL 1574
+D ++ A+V RV N +P F+ + V + E+ G +HV A D D
Sbjct: 2472 SDGLFTST----AQVHIRVL--GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDP 2525
Query: 1575 GEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQV 1634
G ++SY + + L S G + LDRE E +++ R+
Sbjct: 2526 GTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCT 2585
Query: 1635 LTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESF 1694
+ V V D ND AP F EY +R + G + ++A DPD GAN ++TY S S
Sbjct: 2586 VRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASV 2645
Query: 1695 S------LDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHA 1748
S +DPD G + T ++ + ++ V A D G P + + + V + V
Sbjct: 2646 SVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFL 2705
Query: 1749 PTFGSAHLSLEVPE----GQDPQTLTMLRASDPDVGA-NGQLQYRILDGDPSGAFVLDLA 1803
P+F + S + E G TL +L + + NG+ + + G FV++
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERP----ENNKGGIFVIEQE 2761
Query: 1804 SGEFGTMRPLDREVEPAFQLRIEARDG-GQPALSATLLLTVTVLDANDHAPAFPVPAYSV 1862
+G + LDRE PAF ++ A + + T+ + + VLD ND+ P F +Y
Sbjct: 2762 TGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDT 2821
Query: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG-----AFLLEPSSGELRTAAAL 1917
+ E +P GT L Q++A D D GANG VTY L + + AF ++ ++G + T L
Sbjct: 2822 IIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDL 2881
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E P++TFSV A D A LS+T V++ V D+ND+AP F R + P
Sbjct: 2882 DHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP--- 2938
Query: 1978 TPTLALATLRAEDRDAG-ANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDR-- 2034
P +A L DRD N + Y + G P G G ++ P DR
Sbjct: 2939 -PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFA---LGLVQSEWKVYVKRPLDREE 2994
Query: 2035 ----VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSP 2090
L I ATD G A ++ V + + P + + A + E+ P I+
Sbjct: 2995 QDIYFLNITATD-GLFVTQA--MVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKV 3051
Query: 2091 RAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA-ES 2148
A A G+NG I YS L G+ F + P +G + + LD E P L+ +A +
Sbjct: 3052 SAKDADIGSNGYIRYS-LYGSGNSEFFLDPESGELKTLAL--LDRERIPVYSLMAKATDG 3108
Query: 2149 GGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
GG F + + L L+D NDN P F HY + E+ + L +V+A D D G ++ Y
Sbjct: 3109 GGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVY 3168
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRG-SPALVGSATLTVMV 2267
SLA S A G+F +D ++G I LDRE + + + ATD+ +L T+T+ V
Sbjct: 3169 SLADS--AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITV 3226
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQV--TGNDVDSGPVLWYVLSPSGPQDPFSV 2324
+D NDN P + + + V ED G+++ V T D+ + + Y++ Q F +
Sbjct: 3227 LDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKI 3286
Query: 2325 GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---ANLTVLVEDVNDNAPAFSQSLY 2381
G +S++ LD+E C R+ L + A DG A + + + DVNDN P FSQ +Y
Sbjct: 3287 NPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVY 3346
Query: 2382 QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA--DGFSVDPNNGTLFTIVGTVA 2439
++ E G +++ + A D DS NG I + + + + F+VDP L +
Sbjct: 3347 SAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP---VLGLVKVKKK 3403
Query: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
L + ++++A D G P ++ ATV++ + D ND++P FT ++Y + E+ P G+
Sbjct: 3404 LDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGT 3463
Query: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559
++L L TD D + +SI+SGN F L+P G L
Sbjct: 3464 SILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH---------------GILRSAVV 3508
Query: 2560 LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGA 2619
+Y L V A D G+P Q S + V V++ + + P + ED G
Sbjct: 3509 FQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGG 3568
Query: 2620 ELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALD 2666
+ + A+D D + ++ F + S + LF+++ G + LD
Sbjct: 3569 VIGKIHATDQD--MYDVLTFALKS-EQKSLFKVNSHDGKIIALGGLD 3612
Score = 724 bits (1868), Expect = 0.0
Identities = 777/2937 (26%), Positives = 1245/2937 (42%), Gaps = 243/2937 (8%)
Query: 48 DLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
D+ I E P G ++ + + + Y +S E + I+ SG++ TAR L
Sbjct: 382 DVSISEFSPPGVVVAIVKL---SPEPIDVEYKLSPGEDA---VYFKINPRSGLIVTARPL 435
Query: 108 DREQRDRYRFTAVTPDG-ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEP 166
+ +++ Y+ +G +VT+ + D NDH P F Q V E GT
Sbjct: 436 NTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVS 495
Query: 167 ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH-YMLQL 225
A D D G G Y+++ L P + T ELD E+ Y +
Sbjct: 496 ASDKDKGENGYITYSIAS--------LNLLPFVINQFTGVISTTEELDFESSPEIYRFIV 547
Query: 226 EAYDGGSPPRR-AQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADA 284
A D GSP R ++ + + + ++ND++P F + V+S G + V A D D
Sbjct: 548 RASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE 607
Query: 285 GVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFE--QRRVHELVVQARDGG---- 338
V Y+I G F ++ +G+LQL++ L + L + A DG
Sbjct: 608 --LELVKYKIISGNELGF--FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663
Query: 339 --------AHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQ---------------- 374
H ++ S + +I A+G
Sbjct: 664 PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723
Query: 375 -----------VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
V E P G + +I D D G V ++ G + D
Sbjct: 724 YFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNI-DMETGQ 782
Query: 424 VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483
+ V +DRE D Y L +T D G+P + ++V D NDN+P F + Y L
Sbjct: 783 LKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILE 842
Query: 484 EVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ 543
+ G+ +++V ARD D G+NG+VTYS+ T F+I+ ++GI+ A LD E +
Sbjct: 843 SSGI-GTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKAN 899
Query: 544 PQLIVVATDGGLP--PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
L + A D L S T+ V L DVND P F + Y+ + E GT +
Sbjct: 900 YSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLE 959
Query: 602 ATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD 661
D D G G + YSL F ID SG + ++ LD ++ ++ TV A D
Sbjct: 960 THDPDLGLGGQVRYSLVNDYNGR----FEIDKASGAIRLSKELDYEK-QQFYNLTVRAKD 1014
Query: 662 GG---GLKSMVYVKVFLSDENDN--PPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS 716
G L S+ +V+V + D N+N P F S+ S GT+VL++ A D D G
Sbjct: 1015 KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGR 1074
Query: 717 HGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARV 776
G + Y I G+ F++D++SG++T A L R L + A D G + + V
Sbjct: 1075 DGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEV 1134
Query: 777 DISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGGDPRG 835
I + P+ + Y V E+ SV +QA +P +T ++ G+P+
Sbjct: 1135 YIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQN 1194
Query: 836 LFSLDAVSGLLQTL-RPLDRELLGP-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPA 893
F+++ +GL+ T R LDRE LE+ V G P + V +LD+ NDN P
Sbjct: 1195 FFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE-NDNKPQ 1253
Query: 894 FPAPEDTVLLPPNTAP--GTPIYTLRALDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHV 950
FP + LP G PIY A D D G N+ ++++++ G G F +DP TG V
Sbjct: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313
Query: 951 RLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVV-VQDVGTRGLAPRFNSPTYRVDL 1009
+ + G L ++A D G P ++S RL + ++ + F+ P Y +
Sbjct: 1314 SSRKQF--TAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371
Query: 1010 PSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069
T+++ V + P P+ + + S F E G + + LD E + +Y
Sbjct: 1372 MESDRV-TEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYN 1430
Query: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFA 1129
+ V G+ + Q V + +L+ N++ P S+ + ++E+ P T + ++ A
Sbjct: 1431 MSVEVTDGTNVAVTQ------VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEA 1484
Query: 1130 TDRDSGPNGRLTYSLQQL--SEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187
TDRD +L+Y++ S + FRI P TG + T + LD E Q + L + V+D
Sbjct: 1485 TDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Query: 1188 SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEG 1247
P R V V V D ND+SP F A V + G+ V + A D D+G
Sbjct: 1543 FPYRRNLARVIVNVEDANDHSPYFTNPLYEAS------VFESAALGSAVLQVTALDKDKG 1596
Query: 1248 ENGTILYTL-TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQ 1306
EN ++YT+ G +F + P G + +VL++ DQGSPP SA+
Sbjct: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
Query: 1307 LLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALT 1366
+ + V S P +D A V E + G+ SV L
Sbjct: 1657 VRISVTMSDN---SHPKFIHKDYQAEVN--------ENVDIGT---SVILISAISQSTLI 1702
Query: 1367 YTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQV 1426
Y + G D G F ++ SG + + LD+E ++ L ++A G + V +Q+
Sbjct: 1703 YEVKDG-DINGIFTINPYSGVITTQKALDYERTSSYQ-LIIQATNMAGMASNAT-VNIQI 1759
Query: 1427 QDENEHAPAFARDPLALALPENPEPGAALYTF-------RASDADGPGPNSDVRYRLLRQ 1479
DEN++AP F + +L E + + + RA+DAD N+ + Y+++ +
Sbjct: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS-NRNALLVYQIV-E 1817
Query: 1480 EPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
+D+ TGA+ LD ET V D + + V + VTD
Sbjct: 1818 STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDS-GSPQLTAESPVEVNIEVTDV 1876
Query: 1540 NDNAPVFASP---SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHS 1596
NDN PVF + + LP G L V A DPD ++Y L G HF + S
Sbjct: 1877 NDNPPVFTQAVFETILLLPTYV--GVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDS 1934
Query: 1597 STGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV 1656
++G L++ + +H + +V G +T ++T+ V + D F Q YS
Sbjct: 1935 NSGVLTIK---NNNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSFYST 1989
Query: 1657 LLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS-SESFSLDPDTGVL-TTLRALDREEQ 1714
+ ENN T + + A + N + Y ++ F + +GV+ TT DREEQ
Sbjct: 1990 SISENNTNITKVAIVNAVGNRL--NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQ 2047
Query: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLT-MLR 1773
E L V A ++ V VRV +ED ND++P F V +P TL +
Sbjct: 2048 ELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
Query: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPA-FQLRIEARDGGQ 1832
A D D G NG++ Y + D G F ++ SG + ++ + + I A+DGG+
Sbjct: 2108 AIDKDKGPNGEVTYVLQDD--YGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGK 2165
Query: 1833 PALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892
P+LS ++ L +T++ N P F P Y+ V ED+ T +L + A P+ G +
Sbjct: 2166 PSLSTSVELPITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEG--QGIIYI 2221
Query: 1893 YLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
+ F ++ +G L+ + LD E +Y ++ A D TV + V D
Sbjct: 2222 IIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVD--LLVND 2279
Query: 1953 VNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT 2012
VND+ P F L TP L + ++ D D+ N + Y++ T
Sbjct: 2280 VNDNPPIFDQPTYNTTLSEAS-LIGTPVLQVVSI---DADSENNKMVHYQIVQDTYNSTD 2335
Query: 2013 ---VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFP 2069
+DS +G I AR + L + + D G P+ S+ ++ + + + P F
Sbjct: 2336 YFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFN 2395
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGTN-GPITYSILSGNEKGTFSIQPSTGAITVRS 2128
+ E+ + E AP G + +A A ++ + YSILSGN++ +F + +G IT+ +
Sbjct: 2396 QLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSN 2455
Query: 2129 AEGLDFEVSPRLRLVLQAESGGAFAFTV-LTLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187
E L + + S G F T + + + AN +P F + YVA + E+
Sbjct: 2456 HRKQRMEPLYSLNVSV---SDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG 2512
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE--IWAETRL 2245
++ V A D D G+ GQISY++ + A+ F +D + G + TT LDRE + + +
Sbjct: 2513 TKVIHVRATDGDPGTYGQISYAII-NDFAKDRFLID-SNGQVITTERLDRENPLEGDVSI 2570
Query: 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVD 2304
+ A D G T+ V+V+D NDN P + + V D G + QV D D
Sbjct: 2571 FVRALDGGGRTTF--CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPD 2628
Query: 2305 SGP---VLWYVLSPSGPQ--DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL--AHDGPHE 2357
G + + + S + D + G + G +F Q L A DG
Sbjct: 2629 DGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKG--NFNQLKNTVLSFFVKAVDGGIP 2686
Query: 2358 GRANLTVLVEDV---NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYH 2414
+ +L + V P+F+QS Y + E T GS + ++ +
Sbjct: 2687 VKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNV-------- 2738
Query: 2415 LASPADGFSVDPNNGTLFTI---VGTVALGHDGSGAVDVVLEARDHGAPGRAARAT---- 2467
S +G + N G +F I GT+ L D L+ A AT
Sbjct: 2739 WFSTVNGERPENNKGGIFVIEQETGTIKL--------DKRLDRETSPAFHFKVAATIPLD 2790
Query: 2468 ---------VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAV 2518
V +++ D ND+ P F S Y + E +P G+ L + A D D ++ V
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG-ANGQV 2849
Query: 2519 DYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRG 2578
YS+ S + +P + G + L+ LD E+ + +V A+D G
Sbjct: 2850 TYSLHSDS-------QPEKVMEAFNIDSNT---GWISTLKDLDHETDPTFTFSVVASDLG 2899
Query: 2579 QP-PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGP-HGL 2636
+ SS V+V V D+NDN PVF + YR V E P G + + D D +
Sbjct: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQ 2959
Query: 2637 VRFTVSSGDPSGLFELD--ESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTI 2694
V + ++ G+P G F L +S + + LD E Q + L + A D G A V +
Sbjct: 2960 VSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD--GLFVTQAMVEV 3017
Query: 2695 EVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEG 2754
V DVND+ P + + E+ P ++ + A D D G+ G +RYSL +G
Sbjct: 3018 SVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG----- 3072
Query: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFL 2814
F L+ +GEL+ D E + L+ A D G + +++ ++ PVF
Sbjct: 3073 NSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFS 3132
Query: 2815 APAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-PYFGINQTTGALYL 2870
+ ++ V E L VQA D D G + V+YSLA S+ F I+ ++G + L
Sbjct: 3133 SDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIIL 3189
Score = 721 bits (1860), Expect = 0.0
Identities = 751/2893 (25%), Positives = 1251/2893 (43%), Gaps = 267/2893 (9%)
Query: 106 VLDREQRDRYRFT---AVTPDG--ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
+L+RE +D Y +V + A +V ++V D+ND P F ++ + E T T
Sbjct: 116 ILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
Query: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
A DAD G G Y + F + G + ++G L+ + ++
Sbjct: 176 SVAQVTATDADIGSNGEFYYYFKNKV--DLFSVHPTSGV-------ISLSGRLNYDEKNR 226
Query: 221 YMLQLEAYDGG-----SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
Y L++ A D G + + A L V + IN+HAP + + V SL
Sbjct: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTH---VPFSLEKEPTYA 283
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGL----LQLERPLDFEQRRV-HEL 330
V D D G NG + D F L ++ + +D+E + L
Sbjct: 284 VVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNL 343
Query: 331 VVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390
+QA+D G+ P+ SA V++ N + ++ + F +SE +PPG +VA + +
Sbjct: 344 TLQAKDKGS-PQKCSALKAVYI--GNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
Query: 391 SDPDDGDFAHVNVSLEGGEG--HFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG 448
S P+ D V L GE +F ++ + L+ AR L+ +++ Y L VT +
Sbjct: 401 S-PEPID---VEYKLSPGEDAVYFKINPRSG---LIVTARPLNTVKKEVYKLEVTNKEGD 453
Query: 449 SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV 508
+A + + D ND+ P F + LY V + G+ V+ V+A D D+G NG +
Sbjct: 454 -----LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-GTSVLTVSASDKDKGENGYI 507
Query: 509 TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP-QLIVVATDGGLPPL-ASSATVSV 566
TYS+A + F I+ +G+I+T LD+E P+ + IV A+D G P S V++
Sbjct: 508 TYSIA-SLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTI 566
Query: 567 ALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAG--LGSS 624
+ +VNDN P F++ + G V+A D D L+ Y + +G LG
Sbjct: 567 RIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGF- 623
Query: 625 GSPPFRIDAHSGDVCTTRTLDRDQGPS-SFDFTVTAVDGGGLKSMVYVKV---------- 673
F ++ SG + ++L + +F +TA DG L + + +
Sbjct: 624 ----FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSK 679
Query: 674 -----------------------------------FLSDENDNPPQFYPREYAASISAQS 698
F S P ++ + + + ++ +
Sbjct: 680 SFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP--YFDKSFPSDVAVKE 737
Query: 699 --PPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVV 756
P G +L+++A+D D G +G++ + I GN+ F +D ++G L V P+ R +
Sbjct: 738 DLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLY 797
Query: 757 QLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN 816
L I D G Q + I++ P+F Q Y ++ E GT + V+A +
Sbjct: 798 LLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
Query: 817 PP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVR--AGSGVP 872
G VT S+ + F++++ +G++ LDRE L++E R A SG
Sbjct: 858 KDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG-Q 914
Query: 873 PAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFT 932
F+V ++V LDDVND SPAF +V + + GT I L DPD G+ +V ++
Sbjct: 915 QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS 974
Query: 933 LLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFR-LRVVVQDV 991
L+ G F +D +G +RL + L + L + A+D G P S + V V DV
Sbjct: 975 LVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
Query: 992 GTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLE 1048
P F + + GT VLQV A+ D G I Y + F ++
Sbjct: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
Query: 1049 PQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSED 1108
+SG + LDRE Y L V A L T V + + + N+++P SE
Sbjct: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPL---YSTIEVYIEVEDVNDNAPLTSEP 1151
Query: 1109 PTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL-Q 1167
+ V EN P SV ++ A D DS N +LTY + F I+ +TG +TT +
Sbjct: 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS-GNPQNFFAINIKTGLITTTSR 1210
Query: 1168 TLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVP 1227
LDREQQ+ + L V V DGG P+ +T V V VLD NDN P F + I++P
Sbjct: 1211 KLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV------YQIKLP 1264
Query: 1228 --DRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAER 1284
DR G + A D DEG N I Y++ G F + P +G + +
Sbjct: 1265 ERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGS- 1323
Query: 1285 PHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL-----TV 1339
+ +LT+ A D G P +S++ +L ++ + +PPP +P+P+
Sbjct: 1324 -YDILTIKAVDNGRPQKSSTARLHIEWIK-----KPPP--------SPIPLTFDEPFYNF 1369
Query: 1340 TAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAG 1399
T E R ++G V+ +PA L + +VGG + + F + G + +A+PLD E
Sbjct: 1370 TVMESDRVTEIVGVVSV-QPANT-PLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQR 1426
Query: 1400 PPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFR 1459
+ + E G + +V ++V D N++ P F++ + + E+ P +
Sbjct: 1427 SIYN---MSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIE 1483
Query: 1460 ASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRP 1519
A+D D S + + + R+D TG L LD E +L + D+
Sbjct: 1484 ATDRDEKHKLSYTVHSSI-DSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Query: 1520 ANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAA 1578
RR ARV V V D ND++P F +P + E G A L V A D D GE A
Sbjct: 1543 F-PYRRNLARVI--VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENA 1599
Query: 1579 RVSYRLASGGDGH-FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTV 1637
+ Y + +G G+ F++ G +++ + D + VL++ +D GSPP SAT ++ +
Sbjct: 1600 ELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
Query: 1638 SVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLD 1697
SV ++ P F ++Y + EN GTS++ + A +V G ++ F+++
Sbjct: 1660 SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIY-EVKDGDING-IFTIN 1717
Query: 1698 PDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLS 1757
P +GV+TT +ALD E L + A + ++ TV + + DEND+AP F + S
Sbjct: 1718 PYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQYS 1775
Query: 1758 LEVPEGQDPQTLT--------MLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGT 1809
+ E ++ ++RA+D D N L Y+I++ F +D ++G T
Sbjct: 1776 GSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRT 1835
Query: 1810 MRPLDREVEPAFQLRIEARDGGQPALSAT--LLLTVTVLDANDHAPAFPVPAYSVEVPED 1867
+ LD E F + RD G P L+A + + + V D ND+ P F + +
Sbjct: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP 1895
Query: 1868 VPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAA-LDREQCPSYT 1926
G +L++ A DPD+ +TY L G+ FL++ +SG L L ++ Y
Sbjct: 1896 TYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDH---YM 1952
Query: 1927 FSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATL 1986
V DG +T VTI V++ D F S + + + + A
Sbjct: 1953 LIVKVSDGK----FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVG 2008
Query: 1987 RAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRP 2046
N + Y + P + S +G I+ P ++ L+ + + R
Sbjct: 2009 NR------LNEPLKYSILN-PGNKFKIKSTSGVIQTTGVP--FDREEQELYELVVEASRE 2059
Query: 2047 A---RSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPI 2102
R A V+ V ++ + P F A ++ +A PGT I A+ G NG +
Sbjct: 2060 LDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEV 2119
Query: 2103 TYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQ 2162
TY + ++ G F I P++G + ++ A D +L + G T + L +
Sbjct: 2120 TYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPIT 2177
Query: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHV 2222
N P F +P Y A + E + P+L + A +G G I Y + P + F++
Sbjct: 2178 IVNKAMPVFDKPFYTASVNEDIRMNTPILSINATS-PEGQG--IIYIIIDGDPFKQ-FNI 2233
Query: 2223 DPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS---ATLTVMVIDTNDNRPTIPQ 2279
D TG + + LD E+ + +L + A+D AL G+ T+ ++V D NDN P Q
Sbjct: 2234 DFDTGVLKVVSPLDYEVTSAYKLTIRASD----ALTGARAEVTVDLLVNDVNDNPPIFDQ 2289
Query: 2280 P-WELRVSEDALLGSEIAQVTGNDVDS--GPVLWY--VLSPSGPQDPFSVGRYGGRVSLT 2334
P + +SE +L+G+ + QV D DS ++ Y V D F + G +
Sbjct: 2290 PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTA 2349
Query: 2335 GPLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391
LD E L++ + D ++ + + + DVNDN P F+Q +Y+ + E P
Sbjct: 2350 RMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPR 2409
Query: 2392 GSAILSVSATDRDSGANGHISYHLASPAD--GFSVDPNNGTLFTIVGTVALGHDGSGAVD 2449
G + V A+D DS + Y + S D F +D +G + L + ++
Sbjct: 2410 GHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGV-------ITLSNHRKQRME 2462
Query: 2450 VVLEARDHGAPGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATD 2508
+ + G + A VH+++ N ++P+F+ S Y V E++ G+ ++ + ATD
Sbjct: 2463 PLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATD 2522
Query: 2509 ADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQY 2568
D ++ + Y+II+ F + L ++ G ++ E LD E+ +
Sbjct: 2523 GDPG-TYGQISYAIIND-----FAKDRFLIDSN----------GQVITTERLDRENPLEG 2566
Query: 2569 NLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASD 2628
++++ +++ V V V+D NDN P F YR +V D G + V+A D
Sbjct: 2567 DVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAID 2626
Query: 2629 ADPGPHGLVRFTV---SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPA-G 2684
D G + + +++ +S + L E+D +G + + V+A D
Sbjct: 2627 PDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIP 2686
Query: 2685 AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYS 2744
+L PV I V P+F + S ++AE+ G+ V TL + F +
Sbjct: 2687 VKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVN-- 2744
Query: 2745 LLEAGPGPEGREA--FALNSSTGELRARVPFDYEHTESFRLLVGAA---DAGNLSASVTV 2799
G PE + F + TG ++ D E + +F V A D ++ +V V
Sbjct: 2745 ----GERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDV 2800
Query: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS--- 2856
+ V ++ PVF ++ + EG G L V+A D D GA+G V YSL + S
Sbjct: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
Query: 2857 ---PYFGINQTTG 2866
F I+ TG
Sbjct: 2861 KVMEAFNIDSNTG 2873
Score = 671 bits (1731), Expect = 0.0
Identities = 648/2424 (26%), Positives = 1076/2424 (44%), Gaps = 200/2424 (8%)
Query: 533 AASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQ 592
+A L+ E++ LIV + G L + V++ + D+ND P F T Y+ ++ E T
Sbjct: 114 SAILNREIQDNYLLIVKGSVRG-EDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
Query: 593 PGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSS 652
T QVTATDAD G G Y + F + SG + + L+ D+ +
Sbjct: 173 LRTSVAQVTATDADIGSNGEFYYYF-----KNKVDLFSVHPTSGVISLSGRLNYDE-KNR 226
Query: 653 FDFTVTAVDGG-------GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705
+D + AVD G G+ S + V + N++ P + + S + P AV+
Sbjct: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP-FSLEKEPTYAVV 285
Query: 706 RLRAHDPDQGSHGRL-SYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIG--- 761
+ D D G++G + S I+AG+ F L ++ L R+ G
Sbjct: 286 TV--DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNL 343
Query: 762 ---AEDGGGLQAEPSARVDISIVPGTPTPPI-FEQLQYVFSVPEDVAPGTSVGIVQAHNP 817
A+D G Q + + P T PI FE+ Y S+ E PG V IV+
Sbjct: 344 TLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPE 403
Query: 818 PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAV 877
P V LS G+ F ++ SGL+ T RPL+ + V +LEV G
Sbjct: 404 P---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNT-VKKEVYKLEVTNKEGD----LK 455
Query: 878 ARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG 937
A+V + ++D ND++P F P + + GT + T+ A D D G N +T+++ +
Sbjct: 456 AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
Query: 938 GGAFTVDPTTGHVRLMRPLGPSGGP-AHELELEARDGGSPPRTSHFRLRVVVQDVGTRGL 996
F ++ TG + L P + + A D GSP R + V ++
Sbjct: 516 LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYR-HESEVNVTIRIGNVNDN 574
Query: 997 APRFNSPTYRVDLPSGTTAGTQVLQVQA-QAPDGGPITYHLAAEGASSPFGLEPQSGWLW 1055
+P F + + G + V A + + Y + + F L P SG L
Sbjct: 575 SPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQ 634
Query: 1056 VRAALDREA--QELYILKVMAVSGS----------------------------------- 1078
++ +L + L++ A G
Sbjct: 635 LKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAE 694
Query: 1079 ----KAELGQQTGTATVRVSILNQNEHSPRLSED-PTFLAVAENQPPGTSVGRVFATDRD 1133
KA+ + + + N P + P+ +AV E+ P G ++ ++ A D D
Sbjct: 695 KLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDAD 754
Query: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
SG NG++ +++ + DS F I +TG++ L +DRE Y L + + D G+P +S+
Sbjct: 755 SGFNGKVLFTISDGNTDS-CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSS 813
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
+ + V D NDNSP F+Q S + + + GT + ++A+D D G NG +
Sbjct: 814 WRLLTINVEDANDNSPVFIQDS------YSVNILESSGIGTEIIQVEARDKDLGSNGEVT 867
Query: 1254 YTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLP 1313
Y++ ++ F+++ +G + A L R + +Y L + A D ++ S Q L V+
Sbjct: 868 YSVL-TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARD-----KAESGQQLFSVVT 921
Query: 1314 SARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVG 1371
+ D+ + PA +P +V E L G+++ + +P G+G + Y+LV
Sbjct: 922 LKVFLD---DVNDCSPAF-IPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
Query: 1372 GADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGG----AGARLLRVQVQVQ 1427
D G F +D ASG + L++ LD+E + LTVRA+ G + + V+V
Sbjct: 978 --DYNGRFEIDKASGAIRLSKELDYEK-QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
Query: 1428 DENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALR 1487
+EN H P F + ++ EN G ++ A D D G + +++Y +R +
Sbjct: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS-GRDGEIQYS-IRDGSGLGRFS 1092
Query: 1488 LDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA 1547
+D +G ++A LDRET + L V ATDR + + + V D NDNAP+ +
Sbjct: 1093 IDDESGVITAADILDRETMGSYWLTVYATDRGVVP---LYSTIEVYIEVEDVNDNAPLTS 1149
Query: 1548 SPSRVR-LPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVV- 1604
P + E+ P + + + A DPD +++YR+ SG F ++ TG ++
Sbjct: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Query: 1605 RPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLL--RENN 1662
R LDREQ+AEH L V +D G P+ +T + V V D ND P F ++ Y + L R+
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
Query: 1663 PPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQEEINL 1719
G + A D D G N +++Y G F +DP TG++++ + + L
Sbjct: 1270 KRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYD--IL 1327
Query: 1720 TVYAQDRGSPPQLTHVTVRVAVEDENDHAP-----TFGSAHLSLEVPEGQDPQTLTMLRA 1774
T+ A D G P + + T R+ +E P TF + V E + + +
Sbjct: 1328 TIKAVDNGRPQKSS--TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVS 1385
Query: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
P AN L + I+ G+ AF + G +PLD E + + +E DG A
Sbjct: 1386 VQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVA 1442
Query: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYY- 1893
++ + VLD ND+ P F P Y V + EDV T +LQ++A D D T +
Sbjct: 1443 VTQVF---IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHS 1499
Query: 1894 -LGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS-VTITVR 1951
+ + + F ++PS+G L TA LD E + ++ D P ++ V + V
Sbjct: 1500 SIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVIVNVE 1557
Query: 1952 DVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR--AEDRDAGANASILYRL-AGTPP 2008
D NDH+P F T+PL F + L A L+ A D+D G NA ++Y + AG
Sbjct: 1558 DANDHSPYF-TNPL-----YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTG 1611
Query: 2009 PGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF 2068
++ G I + + P VL I TD G P SAT ++ + + P+F
Sbjct: 1612 NMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKF 1671
Query: 2069 PRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRS 2128
+A + EN GT ++ A+ + + Y + G+ G F+I P +G IT +
Sbjct: 1672 IHKDYQAEVNENVDIGTSVILISAI----SQSTLIYEVKDGDINGIFTINPYSGVITTQK 1727
Query: 2129 AEGLDFEVSPRLRLVLQAES-GGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRP-- 2185
A LD+E + +L++QA + G + + + + D NDNAP FL Y L E+ P
Sbjct: 1728 A--LDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
Query: 2186 -----LEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIW 2240
L+ L + A D D + Y + S A+ F VD +TG I T A LD E
Sbjct: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVES-TAKKFFTVDSSTGAIRTIANLDHETI 1844
Query: 2241 AETRLVLMATDRGSPALVGSA--TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQ 2297
A + D GSP L + + + V D NDN P Q +E + +G E+ +
Sbjct: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904
Query: 2298 VTGNDVDS--GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP 2355
V+ D DS P L Y L G D F + G +++ + D Y L + DG
Sbjct: 1905 VSATDPDSEVPPELTYSLM-EGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK 1961
Query: 2356 HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL 2415
+ +T++V++ D+ F+QS Y + E+ + + V+A + N + Y +
Sbjct: 1962 FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--GNRLNEPLKYSI 2019
Query: 2416 ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQ 2475
+P + F + +G + T V + ++V+EA R AR V V ++D
Sbjct: 2020 LNPGNKFKIKSTSGVIQTT--GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077
Query: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEP 2535
ND++P F Y AV D PG+ + + A D D + V Y ++ ++G F++ P
Sbjct: 2078 NDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKD-KGPNGEVTY-VLQDDYGH-FEINP 2134
Query: 2536 RLAEAGESAGPGPRALGCLVLLEPLDFE-SLTQYNLTVAAADRGQPPQSSVVPVTVTVLD 2594
G ++L E + + S +Y +T+ A D G+P S+ V + +T+
Sbjct: 2135 N--------------SGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI-- 2178
Query: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDE 2654
VN PVF + Y +V ED + +L + A+ P G++ + + GDP F +D
Sbjct: 2179 VNKAMPVFDKPFYTASVNEDIRMNTPILSINAT--SPEGQGII-YIIIDGDPFKQFNIDF 2235
Query: 2655 SSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTS 2714
+G L++ LD E + ++L ++A+D A V + V DVND+ P F +T+
Sbjct: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTT 2295
Query: 2715 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFD 2774
++E GT V + +ID D+ + Y +++ + F ++SS+G + D
Sbjct: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQ--DTYNSTDYFHIDSSSGLILTARMLD 2353
Query: 2775 YEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSL 2832
+E + L V + D+G +LS+ V V + ++ ++ PVF + V E A RGH +
Sbjct: 2354 HELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
Query: 2833 GHVQATDEDGGADGLVLYSLATSS 2856
VQA+D D + YS+ + +
Sbjct: 2414 TCVQASDADSSDFDRLEYSILSGN 2437
Score = 562 bits (1448), Expect = e-159
Identities = 582/2107 (27%), Positives = 931/2107 (44%), Gaps = 215/2107 (10%)
Query: 876 AVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA 935
A +V + + D+ND P F +V + +T T + + A D D G N +
Sbjct: 140 AWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYY-YFK 198
Query: 936 GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG-----SPPRTSHFRLRVVVQD 990
F+V PT+G + L L ++LE+ A D G + +S +L V ++
Sbjct: 199 NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIER 258
Query: 991 VGTRGLAPRFN-----------SPTYRV----DLPSGTTAGTQVLQVQAQAPDGGPIT-Y 1034
+ AP + PTY V DL G + + + A G P+ +
Sbjct: 259 INEH--APTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVA----GDPLDQF 312
Query: 1035 HLAAEGASSPFGLEPQSGWLWVRAALDREAQEL--------YILKVMAVSGSKAELGQQT 1086
LA EG W+ +E +++ Y L + A K + Q
Sbjct: 313 FLAKEGK-------------WLNEYKIKERKQIDWESFPYGYNLTLQA----KDKGSPQK 355
Query: 1087 GTATVRVSILNQNEHSP--RLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
+A V I N + R ++ ++++E PPG V V + +L+
Sbjct: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPG- 414
Query: 1145 QQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDL 1204
ED+ F+I+P++G + T + L+ ++ Y+L V ++G + T +++ D
Sbjct: 415 ----EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVT-----ISIEDA 465
Query: 1205 NDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELF 1264
ND++P F Q A V + VP GT V T+ A D D+GENG I Y++ F
Sbjct: 466 NDHTPEFQQPLYDA------YVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPF 519
Query: 1265 SLHPHSGELLTAAPLIRAERPH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323
++ +G + T L P Y + A D GSP R S + + + P
Sbjct: 520 VINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP--- 576
Query: 1324 LAERDPAAPV-----PVVLTVTAAEGLR------------PGSLLGSVAAPEPAGVGALT 1366
L E+ V PV +TA + G+ LG +GV L
Sbjct: 577 LFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLK 636
Query: 1367 YTLVGGADPEGTFALD-AASGRLYLARPLDFEAGP-----PWRALTVRAEGPGGAGARLL 1420
+L G FAL A+ LA P+ ++ + R A L
Sbjct: 637 KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
Query: 1421 RVQVQVQDE-------------NEHAPAFARD-PLALALPENPEPGAALYTFRASDADGP 1466
++ + + N P F + P +A+ E+ GA + +A DAD
Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADS- 755
Query: 1467 GPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD--RPANASR 1524
G N V + + +D TG L +DRE T LL + D P +S
Sbjct: 756 GFNGKVLFTISDGNTD-SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSW 814
Query: 1525 RRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR 1583
R + V D NDN+PVF S V + E G + V ARD DLG V+Y
Sbjct: 815 RLLT-----INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYS 869
Query: 1584 LASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVA--D 1641
+ + F ++SSTG + V LDRE +A + L + A D + V+T+ V D
Sbjct: 870 VLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Query: 1642 VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES--FSLDPD 1699
VND +P F YSV + E+ P GT + L DPD+G GQV Y V+ + F +D
Sbjct: 929 VNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKA 988
Query: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVT---VRVAVEDENDHAPTFGSAHL 1756
+G + + LD E+Q+ NLTV A+D+G P L+ V+ V V +EN H P F +
Sbjct: 989 SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
Query: 1757 SLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
V E T + + A D D G +G++QY I DG G F +D SG LDR
Sbjct: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDR 1108
Query: 1816 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
E ++ L + A D G L +T+ + + V D ND+AP P Y V E+ P ++
Sbjct: 1109 ETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Query: 1876 QLQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELRTAAA-LDREQCPSYTFSVSAVD 1933
Q+QA DPD+ +N +TY + +G F + +G + T + LDREQ + V+ D
Sbjct: 1169 QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTD 1228
Query: 1934 GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDA 1993
G + P +T+ V + V D ND+ P FP +++LP + A A DRD
Sbjct: 1229 GGPS-PKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAF--AFDRDE 1285
Query: 1994 GANASILYRLAGTPPPGTT-VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG 2052
G NA I Y + G +D TG + +R G D +L I A D GRP +S+T
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVS-SRKQFTAGSYD-ILTIKAVDNGRPQKSSTA 1343
Query: 2053 VIIVGLQGEAERGP---RFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSG 2109
+ + + P F T+ E+ T IV +V T P+ + I+ G
Sbjct: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVVSVQPANT--PLWFDIVGG 1400
Query: 2110 NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAP 2169
N F + G I + A+ LD E + ++ G A T + + + D NDN P
Sbjct: 1401 NFDSAFDAEKGVGTIVI--AKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGP 1458
Query: 2170 RFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL--FHVDPTTG 2227
F +P+Y + E + +LQ+EA D D+ ++SY++ +S + + F +DP+TG
Sbjct: 1459 EFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISMRKFRIDPSTG 1516
Query: 2228 TITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVS 2286
+ T LD E + L +M D+ P A + V V D ND+ P P +E V
Sbjct: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
Query: 2287 EDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDR 2344
E A LGS + QVT D D G L Y + + F + G +++ D +
Sbjct: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQ 1636
Query: 2345 YQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSAT 2401
+ L + D P A + + V +++ P F YQ + E+ G++++ +SA
Sbjct: 1637 FVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI 1696
Query: 2402 DRDSGANGHISYHLASPADG-----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
+ + + Y + DG F+++P +G + T AL ++ + + ++++A +
Sbjct: 1697 SQST-----LIYEVK---DGDINGIFTINPYSGVITT---QKALDYERTSSYQLIIQATN 1745
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTL-------LTLEATDA 2509
G A+ ATV++Q+ D+ND+AP F S Y +++E P S + L + ATDA
Sbjct: 1746 MA--GMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803
Query: 2510 DGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYN 2569
D +R+ A + Y I+ + F ++ + G + + LD E++ ++
Sbjct: 1804 DSNRN-ALLVYQIVESTAKKFFTVDS--------------STGAIRTIANLDHETIAHFH 1848
Query: 2570 LTVAAADRGQPPQSSVVPVTVT--VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
V D G P ++ PV V V DVNDNPPVFT+A + + T VG E+L V A+
Sbjct: 1849 FHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAT 1908
Query: 2628 DADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF 2687
D D + +++ G F +D +SG L + + + ++ + L+V+ +D G +
Sbjct: 1909 DPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD--GKFY 1963
Query: 2688 ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE 2747
+ + VTI V++ D G F + STS++EN T V ++A+ L+YS+L
Sbjct: 1964 STSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE--PLKYSILN 2021
Query: 2748 AGPGPEGREAFALNSSTGELRAR-VPFDYEHTESFRLLVGAA-DAGNLS-ASVTVSVLVT 2804
G F + S++G ++ VPFD E E + L+V A+ + +L A V V V +
Sbjct: 2022 PG------NKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIE 2075
Query: 2805 GEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQT 2864
++ PVF+ ++ V A G + V A D+D G +G V Y L +F IN
Sbjct: 2076 DINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPN 2135
Query: 2865 TGALYLR 2871
+G + L+
Sbjct: 2136 SGNVILK 2142
Score = 541 bits (1394), Expect = e-153
Identities = 521/1915 (27%), Positives = 846/1915 (44%), Gaps = 188/1915 (9%)
Query: 1058 AALDREAQELYILKVM-AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAE 1116
A L+RE Q+ Y+L V +V G E + V + +L+ N+ P S + +AE
Sbjct: 115 AILNREIQDNYLLIVKGSVRGEDLEAWTK-----VNIQVLDMNDLRPLFSPTTYSVTIAE 169
Query: 1117 NQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSS 1176
+ P TSV +V ATD D G NG Y + + F +HP +G ++ L+ ++++
Sbjct: 170 STPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVISLSGRLNYDEKNR 226
Query: 1177 YQLLVQVQDG-----GSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVP 1231
Y L + D G+ S+T ++V + +N+++PT + VP +
Sbjct: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---------HVVTHVPFSLE 277
Query: 1232 PGTLVTTLQAKDPDEGENGTI--LYTLTGPGSELFSLHPHSGELLTAAPLIRAER----- 1284
+ D D+G NG I + + G + F L G+ L + ++
Sbjct: 278 KEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEGKWLNEYKIKERKQIDWES 336
Query: 1285 -PH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAA 1342
P+ Y LTL A D+GSP + ++L+ + + P D P V V+ +
Sbjct: 337 FPYGYNLTLQAKDKGSPQKCSALK-------AVYIGNPTRDTV---PIRFEKEVYDVSIS 386
Query: 1343 EGLRPGSLLGSV-AAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPP 1401
E PG ++ V +PEP V Y L G D F ++ SG + ARPL+
Sbjct: 387 EFSPPGVVVAIVKLSPEPIDV---EYKLSPGEDAV-YFKINPRSGLIVTARPLNTVKKEV 442
Query: 1402 WRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
++ EG A +V + ++D N+H P F + + E+ G ++ T AS
Sbjct: 443 YKLEVTNKEGDLKA-----QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 1462 DADGPGPNSDVRYRL--LRQEPPVPALRLDARTGALSAPRGLDRETTPALL-LLVEATDR 1518
D D G N + Y + L P V ++ TG +S LD E++P + +V A+D
Sbjct: 498 DKD-KGENGYITYSIASLNLLPFV----INQFTGVISTTEELDFESSPEIYRFIVRASD- 551
Query: 1519 PANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEA 1577
+ R + V+ + + + NDN+P+F + + + D P G V A D D E
Sbjct: 552 -WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--EL 608
Query: 1578 ARVSYRLASGGD-GHFRLHSSTGALSVVRPLDRE--QRAEHVLTVVASD----------- 1623
V Y++ SG + G F L+ +G L + + L + L + A+D
Sbjct: 609 ELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSIN 668
Query: 1624 ----HGSPPRSATQVLTVSVA---------------------------DVNDEAPTFQQQ 1652
HG + VA +N + P F +
Sbjct: 669 ISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKS 728
Query: 1653 EYS-VLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA 1708
S V ++E+ P G ++L ++A D D G NG+V + G + F++D +TG L L
Sbjct: 729 FPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMP 788
Query: 1709 LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768
+DRE + L + D G+P + + + + VED ND++P F S+ + E T
Sbjct: 789 MDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
Query: 1769 -LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEA 1827
+ + A D D+G+NG++ Y +L + F ++ ++G LDRE + + L+IEA
Sbjct: 849 EIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEA 906
Query: 1828 RDGGQPA--LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAG 1885
RD + L + + L V + D ND +PAF +YSV+V ED+P GT++ L+ HDPD G
Sbjct: 907 RDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG 966
Query: 1886 ANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
G V Y L G F ++ +SG +R + LD E+ Y +V A D LS+
Sbjct: 967 LGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSF 1026
Query: 1946 VTITVRDVND--HAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003
V + V DVN+ H P FP + + + T L + A D D+G + I Y +
Sbjct: 1027 VEVEVVDVNENLHTPYFPDFAV-VGSVKENSRIGTSVLQVT---ARDEDSGRDGEIQYSI 1082
Query: 2004 A-GTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEA 2062
G+ ++D +G I A L + ATD G +T + + ++
Sbjct: 1083 RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVN 1142
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPST 2121
+ P + EN+P ++ +A +N +TY I SGN + F+I T
Sbjct: 1143 DNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKT 1202
Query: 2122 GAITVRSAEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDANDNAPRFLRPHYVA 2178
G IT S + LD E L + GG + + + + D NDN P+F Y
Sbjct: 1203 GLITTTSRK-LDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQI 1261
Query: 2179 FLPE-SRPLEG-PLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILD 2236
LPE R G P+ + A D D+G +ISYS+ G F +DP TG +++
Sbjct: 1262 KLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGND-DGKFFIDPKTGMVSSRKQFT 1320
Query: 2237 REIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRP---TIPQPWELRVSEDALLGS 2293
+ L + A D G P +A L + I P T +P+ ++ +
Sbjct: 1321 AGSY--DILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVT 1378
Query: 2294 EIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD 2353
EI V + P LW+ + F + G + + PLD EQ Y + + D
Sbjct: 1379 EIVGVVSVQPANTP-LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD 1437
Query: 2354 GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISY 2413
G + + + V D NDN P FSQ Y V + E P + IL + ATDRD +SY
Sbjct: 1438 GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSY 1495
Query: 2414 HLASPADG-----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468
+ S D F +DP+ G L+T L H+ + + RD P R A V
Sbjct: 1496 TVHSSIDSISMRKFRIDPSTGVLYT---AERLDHEAQDKHILNIMVRDQEFPYRRNLARV 1552
Query: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG 2528
V ++D NDH+P FT Y +V E GS +L + A D D +A + Y+I +GN G
Sbjct: 1553 IVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD-KGENAELIYTIEAGNTG 1611
Query: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV 2588
+F++EP LG + + + D ++ Q+ L++ D+G PP S+ V
Sbjct: 1612 NMFKIEP--------------VLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657
Query: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSG 2648
++V +++ P F Y+ V E+ +G ++ + A + + V GD +G
Sbjct: 1658 RISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGDING 1712
Query: 2649 LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPL 2708
+F ++ SG + ALD E + +QL++QA + AG + A V I++ D ND+ P F
Sbjct: 1713 IFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGM-ASNATVNIQIVDENDNAPVFLF 1771
Query: 2709 NLLSTSVAENQPPGTLVTTL-------HAIDGDAGAFGRLRYSLLEAGPGPEGREAFALN 2761
+ S S++E P ++V +L A D D+ L Y ++E+ ++ F ++
Sbjct: 1772 SQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVES----TAKKFFTVD 1827
Query: 2762 SSTGELRARVPFDYEHTESFRLLVGAADAGN----LSASVTVSVLVTGEDEYDPVFLAPA 2817
SSTG +R D+E F V D+G+ + V V++ VT ++ PVF
Sbjct: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
Query: 2818 FHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-PYFGINQTTGALYLR 2871
F + G + V ATD D + YSL S +F I+ +G L ++
Sbjct: 1888 FETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIK 1942
Score = 453 bits (1166), Expect = e-126
Identities = 478/1875 (25%), Positives = 817/1875 (43%), Gaps = 205/1875 (10%)
Query: 1169 LDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPD 1228
L+RE Q +Y L+V+ G + T V++ VLD+ND P F + + + + +
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWT-KVNIQVLDMNDLRPLFSPTTYS------VTIAE 169
Query: 1229 RVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYV 1288
P T V + A D D G NG Y +LFS+HP SG + + L E+ Y
Sbjct: 170 STPLRTSVAQVTATDADIGSNGEFYYYFKNK-VDLFSVHPTSGVISLSGRLNYDEKNRYD 228
Query: 1289 LTLSAHDQG-----SPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
L + A D+G + S++ +L V + R+ E P + VV V +
Sbjct: 229 LEILAVDRGMKLYGNNGVSSTAKLYVHI---ERINEHAPT---------IHVVTHVPFSL 276
Query: 1344 GLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGR------LYLARPLDFE 1397
P + +V + G + + DP F L A G+ + + +D+E
Sbjct: 277 EKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEGKWLNEYKIKERKQIDWE 335
Query: 1398 AGPPWRALTVRAEGPGGAG--ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAAL 1455
+ P LT++A+ G + L V + + F ++ +++ E PG +
Sbjct: 336 SFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Query: 1456 YTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEA 1515
+ S P P DV Y+L E V +++ R+G + R L+ T + +E
Sbjct: 396 AIVKLS----PEP-IDVEYKLSPGEDAV-YFKINPRSGLIVTARPLN--TVKKEVYKLEV 447
Query: 1516 TDRPANASRRRAARVSARVFVTDENDNAPVFASPSR-VRLPEDQPPGPAALHVVARDPDL 1574
T++ + + + + D ND+ P F P + E P G + L V A D D
Sbjct: 448 TNKEGDL------KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDK 501
Query: 1575 GEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV-ASDHGSPPRSATQ 1633
GE ++Y +AS F ++ TG +S LD E E +V ASD GSP R ++
Sbjct: 502 GENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESE 561
Query: 1634 V-LTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE 1692
V +T+ + +VND +P F++ ++ + P G + + A D D V Y +S
Sbjct: 562 VNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--ELELVKYKIISGN 619
Query: 1693 S---FSLDPDTGVLTTLRALDREEQEEIN----LTVYAQDRGSPPQLTHVTV-------- 1737
F L+PD+GVL ++L + N +T + + P +++V
Sbjct: 620 ELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSK 679
Query: 1738 -------RVA------------------VEDE-------NDHAPTFGSAHLS-----LEV 1760
RVA +ED N P F + S ++
Sbjct: 680 SFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDL 739
Query: 1761 PEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPA 1820
P G + + ++A D D G NG++ + I DG+ F +D+ +G+ + P+DRE
Sbjct: 740 PVGAN---ILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL 796
Query: 1821 FQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAH 1880
+ L I D G P S+ LLT+ V DAND++P F +YSV + E GT ++Q++A
Sbjct: 797 YLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEAR 856
Query: 1881 DPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG-P 1939
D D G+NG VTY + T F + S+G + A LDRE +Y+ + A D A +G
Sbjct: 857 DKDLGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQ 915
Query: 1940 LSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASI 1999
L + V++ + + DVND +P F S +++ P + +A L D D G +
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGT----VIAWLETHDPDLGLGGQV 971
Query: 2000 LYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQ 2059
Y L +D +G IR+++ + L + A D GRP S + V V ++
Sbjct: 972 RYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV-SLSSVSFVEVE 1030
Query: 2060 ----GEAERGPRFPRASSEATIRENAPPGTPIVSPRA-VHAGGTNGPITYSILSGNEKGT 2114
E P FP + +++EN+ GT ++ A G +G I YSI G+ G
Sbjct: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR 1090
Query: 2115 FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRF 2171
FSI +G IT +A+ LD E L + A G ++ + + ++D NDNAP
Sbjct: 1091 FSIDDESGVIT--AADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLT 1148
Query: 2172 LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITT 2231
P Y + E+ P + ++Q++A+D D S +++Y + + P + F ++ TG ITT
Sbjct: 1149 SEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP-QNFFAINIKTGLITT 1207
Query: 2232 TA-ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSE-- 2287
T+ LDRE AE L + TD G + + V V+D NDN+P P+ +++++ E
Sbjct: 1208 TSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
Query: 2288 DALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRY 2345
G I + D D GP + Y + F + G VS D
Sbjct: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDIL 1327
Query: 2346 QLQLLAHDGPHEGRANLTVLVEDVNDNAPA-----FSQSLYQVMLLEHTPPGSAILSVSA 2400
++ + + P + + + +E + P+ F + Y ++E + VS
Sbjct: 1328 TIKAVDNGRPQKS-STARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSV 1386
Query: 2401 TDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
AN + + + + D G + TIV L + ++ +E D
Sbjct: 1387 ----QPANTPLWFDIVGGNFDSAFDAEKG-VGTIVIAKPLDAEQRSIYNMSVEVTD---G 1438
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
A V +++ D ND+ P F+ +Y V ++ED+ P + +L +EATD D + +
Sbjct: 1439 TNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVH 1498
Query: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
S I R F+++P + G L E LD E+ ++ L + D+ P
Sbjct: 1499 SSIDSISMRKFRIDP--------------STGVLYTAERLDHEAQDKHILNIMVRDQEFP 1544
Query: 2581 PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT 2640
+ ++ V V V D ND+ P FT Y +V E +G+ +L V A D D G + + +T
Sbjct: 1545 YRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYT 1604
Query: 2641 VSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD---PAGAHFALAPVTIEVQ 2697
+ +G+ +F+++ G + + D T + L ++ D P + A+ +++ +
Sbjct: 1605 IEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMS 1664
Query: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA 2757
D N H P F V EN GT V + AI + +L+ +
Sbjct: 1665 D-NSH-PKFIHKDYQAEVNENVDIGTSVILISAIS---------QSTLIYEVKDGDINGI 1713
Query: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPA 2817
F +N +G + + DYE T S++L++ A + ++++ TV++ + E++ PVFL
Sbjct: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQ 1773
Query: 2818 FHFQVPEGARRG---HSLGH----VQATDEDGGADGLVLYSL--ATSSPYFGINQTTGAL 2868
+ + E A SL + ++ATD D + L++Y + +T+ +F ++ +TGA+
Sbjct: 1774 YSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAI 1833
Query: 2869 --------------YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSA 2914
+ V R GS T+ E+P E+ +EV P +
Sbjct: 1834 RTIANLDHETIAHFHFHVHVRDSGSPQLTA--------ESPVEVNIEVTDVNDNPPVFTQ 1885
Query: 2915 TVPVTVDITHTALGL 2929
V T+ + T +G+
Sbjct: 1886 AVFETILLLPTYVGV 1900
Score = 343 bits (879), Expect = 2e-93
Identities = 358/1360 (26%), Positives = 581/1360 (42%), Gaps = 158/1360 (11%)
Query: 1580 VSYRLASGGDGHF--------------RLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
+ YR+ SG + F R+ + G ++ L+RE + ++L V S G
Sbjct: 79 IKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAI---LNREIQDNYLLIVKGSVRG 135
Query: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVT 1685
+ T+V + V D+ND P F YSV + E+ P TS+ + ATD D+G+NG+
Sbjct: 136 EDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFY 194
Query: 1686 YGGVSS-ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRG-----SPPQLTHVTVRV 1739
Y + + FS+ P +GV++ L+ +E+ +L + A DRG + + + V
Sbjct: 195 YYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYV 254
Query: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGANGQLQ-YRILDGDPSGA 1797
+E N+HAPT H+ VP + + T ++ D D GANG+++ I+ GDP
Sbjct: 255 HIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQ 311
Query: 1798 FVLD-----LASGEFGTMRPLDREVEP-AFQLRIEARDGGQPALSATLLLTVTVLDANDH 1851
F L L + + +D E P + L ++A+D G P + L D
Sbjct: 312 FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDT 371
Query: 1852 APA-FPVPAYSVEVPEDVPAGTL--LLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPS 1907
P F Y V + E P G + +++L D V Y L G A F + P
Sbjct: 372 VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFKINPR 425
Query: 1908 SGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL 1967
SG + TA L+ + Y V+ +G VTI++ D NDH P F PL
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEG------DLKAQVTISIEDANDHTPEFQ-QPLYD 478
Query: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPV 2027
T L T+ A D+D G N I Y +A ++ +TG I
Sbjct: 479 AYVNESVPVGTSVL---TVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELD 535
Query: 2028 ALGPRDRVLFIV-ATDLGRPARSATGV-IIVGLQGEAERGPRFPRASSEATIRENAPPGT 2085
+ FIV A+D G P R + V + + + + P F + + + I + P G
Sbjct: 536 FESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGG 595
Query: 2086 PIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGA--------------------IT 2125
I + A+ + Y I+SGNE G F + P +G IT
Sbjct: 596 HITAVSAIDIDELE-LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRIT 654
Query: 2126 VRSAEGL-----------------------DFEVSPRL--RLVLQAESGGAFAFTVLTLT 2160
E L + V+ +L +L+++A++ G L
Sbjct: 655 ATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLD 714
Query: 2161 LQDANDNAPRFLR--PHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG 2218
N P F + P VA + E P+ +L+++A D D G G++ ++++
Sbjct: 715 FYSINRQGPYFDKSFPSDVA-VKEDLPVGANILKIKAYDADSGFNGKVLFTISDGN-TDS 772
Query: 2219 LFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT-I 2277
F++D TG + +DRE L + D G+P LT+ V D NDN P I
Sbjct: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI 832
Query: 2278 PQPWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVSLT 2334
+ + + E + +G+EI QV D D +G V + VL+ + F++ G V +
Sbjct: 833 QDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT---QQFAINSSTGIVYVA 889
Query: 2335 GPLDFEQCDRYQLQLLAHDGPHEGR-----ANLTVLVEDVNDNAPAFSQSLYQVMLLEHT 2389
LD E Y L++ A D G+ L V ++DVND +PAF S Y V +LE
Sbjct: 890 DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDL 949
Query: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAV 2448
P G+ I + D D G G + Y L + +G F +D +G + + L ++
Sbjct: 950 PVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRL---SKELDYEKQQFY 1006
Query: 2449 DVVLEARDHGAP-GRAARATVHVQLQDQND--HAPSFTLSHYRVAVTEDLPPGSTLLTLE 2505
++ + A+D G P ++ + V V++ D N+ H P F +V E+ G+++L +
Sbjct: 1007 NLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVT 1066
Query: 2506 ATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESL 2565
A D D R + YSI G+ F ++ G + + LD E++
Sbjct: 1067 ARDEDSGRD-GEIQYSIRDGSGLGRFSIDDE--------------SGVITAADILDRETM 1111
Query: 2566 TQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVE 2625
Y LTV A DRG P S + V + V DVNDN P+ + Y V E++P ++ ++
Sbjct: 1112 GSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQ 1171
Query: 2626 ASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL-RLAHALDCETQARHQLVVQAAD--P 2682
A D D + + + ++SG+P F ++ +G + + LD E QA H L V D P
Sbjct: 1172 AEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGP 1231
Query: 2683 AGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAE--NQPPGTLVTTLHAIDGDAGAFGR 2740
+ + V ++V D ND+ P FP + + E + G + A D D G
Sbjct: 1232 SPKQSTIW-VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
Query: 2741 LRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVS 2800
+ YS+++ +G+ F ++ TG + +R F + L + A D G S T
Sbjct: 1291 ISYSIVDG--NDDGK--FFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTAR 1344
Query: 2801 VLVTGEDEYDP-----VFLAPAFHFQVPEGARRGHSLGHV 2835
+ + + P F P ++F V E R +G V
Sbjct: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV 1384
Score = 310 bits (795), Expect = 1e-83
Identities = 267/880 (30%), Positives = 403/880 (45%), Gaps = 53/880 (6%)
Query: 43 QAGSLDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFI-SAQEGSGVGTDLAIDEHSGV 100
+ S D I E P GT + + A + G + Y + S + V ID ++G
Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGW 2874
Query: 101 VRTARVLDREQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVP 153
+ T + LD E + F+ V D +T V+VRV DIND+AP F Q V
Sbjct: 2875 ISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVK 2934
Query: 154 EHTAFGTRYPLEPARDADAGRLGTQ-GYALSGDGAGETFRLETRPGPDGTPVPE--LVVT 210
E G + D D + Q Y ++G F L G E + V
Sbjct: 2935 ESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFAL-------GLVQSEWKVYVK 2987
Query: 211 GELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270
LDRE + Y L + A DG QA+++V++ D+ND++P +Q Y A++ E +
Sbjct: 2988 RPLDREEQDIYFLNITATDGLFV---TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
Query: 271 GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330
+L+V A DAD G NG + Y + G+ F +D +G L+ LD E+ V+ L
Sbjct: 3045 NKIILKVSAKDADIGSNGYIRYSL---YGSGNSEFFLDPESGELKTLALLDRERIPVYSL 3101
Query: 331 VVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390
+ +A DGG + + + + D NDN P +F S + V E L+ R+
Sbjct: 3102 MAKATDGGGR--FCQSNIHLILEDVNDNPP----VFSSDHYNTCVYENTATKALLTRVQA 3155
Query: 391 SDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATD-SG 448
DPD G V SL + G F++ + +I L + LDRE++ +YN+ V ATD S
Sbjct: 3156 VDPDIGINRKVVYSLADSAGGVFSIDSSSGIIIL---EQPLDREQQSSYNISVRATDQSP 3212
Query: 449 SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV 508
L + + V D+NDN P F+R+ Y +PE PG+ V+ V A D GTN ++
Sbjct: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVT-VPEDTSPGTQVLAVFATSKDIGTNAEI 3271
Query: 509 TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVAL 568
TY + G F I+P +G I+ + LDYEL + L+V A DGG P L++ ATV++ L
Sbjct: 3272 TYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINL 3331
Query: 569 QDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
DVNDN P+F + Y+A + E G + + A D DS P G + +S+ +
Sbjct: 3332 TDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSI---VNGDRDNE 3388
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFY 686
F +D G V + LDR++ S + V AVD G + S V + +SD NDN P F
Sbjct: 3389 FTVDPVLGLVKVKKKLDRER-VSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFT 3447
Query: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHG-RLSYHILAGNSPPLFTLDEQSGLLTVA 745
P Y A I P GT++L+L D D +G S+ IL+GN F LD G+L A
Sbjct: 3448 PANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GILRSA 3506
Query: 746 WPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAP 805
+ L + A+D G Q + + ++ + P L+ ED P
Sbjct: 3507 VVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFP 3566
Query: 806 GTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEV 865
G +G + A + + V + + LF +++ G + L LD VL + V
Sbjct: 3567 GGVIGKIHATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKY--VLNVSV 3622
Query: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAF----PAPEDTV 901
G P V V L+ ++ N+ +PED V
Sbjct: 3623 SDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFV 3662
Score = 215 bits (548), Expect = 5e-55
Identities = 236/898 (26%), Positives = 383/898 (42%), Gaps = 125/898 (13%)
Query: 2057 GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPR--AVHAGGTNGPITYSILSGNEKGT 2114
GL G G F + AT+ EN+ T + S + + I Y I+SG+E+G
Sbjct: 32 GLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGF 91
Query: 2115 FSIQPSTGA----ITVRSAEG----LDFEVSPRLRLVLQAESGGAF--AFTVLTLTLQDA 2164
F + A + +R+ G L+ E+ L+++ G A+T + + + D
Sbjct: 92 FKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDM 151
Query: 2165 NDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDP 2224
ND P F Y + ES PL + QV A D D GS G+ Y + LF V P
Sbjct: 152 NDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF---KNKVDLFSVHP 208
Query: 2225 TTGTITTTAILDREIWAETRLVLMATDR-----GSPALVGSATLTVMVIDTNDNRPTIPQ 2279
T+G I+ + L+ + L ++A DR G+ + +A L V + N++ PTI
Sbjct: 209 TSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV 268
Query: 2280 PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGG-----RV 2331
+ S + A VT +D+D +G + + P D F + + G ++
Sbjct: 269 VTHVPFSLEK--EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKI 326
Query: 2332 SLTGPLDFEQCD-RYQLQLLAHD--GPHEGRANLTVLV-EDVNDNAP-AFSQSLYQVMLL 2386
+D+E Y L L A D P + A V + D P F + +Y V +
Sbjct: 327 KERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSIS 386
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTI--VGTVALGH 2442
E +PPG + V + + Y L+ D F ++P +G + T + TV
Sbjct: 387 EFSPPGVVVAIVKLSPEPI----DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTV---K 439
Query: 2443 DGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLL 2502
++V + D +A V + ++D NDH P F Y V E +P G+++L
Sbjct: 440 KEVYKLEVTNKEGD-------LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVL 492
Query: 2503 TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
T+ A+D D + + YSI S N L P + + G + E LDF
Sbjct: 493 TVSASDKD-KGENGYITYSIASLN------LLPFVIN---------QFTGVISTTEELDF 536
Query: 2563 ESLTQ-YNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAE 2620
ES + Y V A+D G P S V VT+ + +VNDN P+F + + + + D PVG
Sbjct: 537 ESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGH 596
Query: 2621 LLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHAL--------------- 2665
+ V A D D LV++ + SG+ G F L+ SG L+L +L
Sbjct: 597 ITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRIT 654
Query: 2666 ---------------------------DC-ETQARHQLVVQAADPAGAH--FALAPVTIE 2695
C ET+ +L + A A+ L ++
Sbjct: 655 ATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLD 714
Query: 2696 VQDVNDHGPAFPLNLLS-TSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEG 2754
+N GP F + S +V E+ P G + + A D D+G G++ +++ +
Sbjct: 715 FYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTD--- 771
Query: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PV 2812
F ++ TG+L+ +P D EHT+ + L + D GN S + + ED D PV
Sbjct: 772 -SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
Query: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
F+ ++ + E + G + V+A D+D G++G V YS+ T + F IN +TG +Y+
Sbjct: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYV 888
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 807 bits (2085), Expect = 0.0
Identities = 506/1305 (38%), Positives = 714/1305 (54%), Gaps = 85/1305 (6%)
Query: 25 LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQE 84
LL LL+ + G+ Q +L L +DE P TL+GDI AGLPA F +++
Sbjct: 47 LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
Query: 85 G--SGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPA 142
S + D + +G++RTAR LDRE+RD Y F A T GA V+V +RV D+NDH+P
Sbjct: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPR 166
Query: 143 FPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL------SGDGAGETFRLETR 196
FP L V E + GT + L A D DAG TQGY L D AG F+L R
Sbjct: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
Query: 197 -PGPDGTPVP----------ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTL 245
PGP +P+ +LV+ LDRE + + LQ+EA+DGG P R +++ +
Sbjct: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
Query: 246 LDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP- 304
LD ND+ P F Q Y A V E PG+ V +V A+D D G NG V Y + RQ G G
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
Query: 305 ---------FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355
F+++ +G++++ RPLD E + H+LVV+ARDGGA PE+ + V++ V D
Sbjct: 347 GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
Query: 356 NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF----------------A 399
NDN+P++ V+FL+ G +VSE A PG VAR+SVSD D GD+
Sbjct: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD-GDWEKEDEATGELGVGLGDG 465
Query: 400 HVNVSLEGGEGHFALSTQDSV-IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF 458
+++SLEGGEG FAL ++ +CV LDRE RD Y L + ATD+GSPPL E
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 459 VLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ------VTYSL 512
+L V D+ND P F +Q Y+ + E A PG+ V+ V+A D D+ + V
Sbjct: 526 LLRVADLNDQPPLFSQQHYKAS-VSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 513 APG---------AHTHW----FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559
AP HT F+ID SG I+T +LD E++ +L VVA D G PPL+
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
++ VS+ + DVNDNEP F R YNA++ E G CFLQVTA+DADSG +G + YSL
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
Query: 620 GLGSSGSPP-FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
G S +P FRID H G +C ++ +DR++ P+++D V A DGGGL + +V+V L D
Sbjct: 705 GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQ 738
NDN P F P Y SIS ++ PGT ++ + A D D G +G ++Y ++ GN LFT+D
Sbjct: 765 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
Query: 739 SGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFS 798
+G++ + PL+ ++ + L + A+DGGGL A +A V I I T P FE+ +Y F
Sbjct: 825 TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
Query: 799 VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
V EDV + +G V+A P P+ +S GD G FS+ G ++T +PLD E
Sbjct: 885 VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE-TQ 943
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
PV+ L V+A G PA + V + + DVNDN PAF D + + T PGT +Y RA
Sbjct: 944 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
D DSG N + +++ + G F +D G + L LG L L A D G P+
Sbjct: 1004 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
Query: 979 TSHFRLRVVVQDVGTRGLAP--RFNSPTYRVDLPSGTTAGTQVLQVQAQ--APD--GGPI 1032
+ L VV++ R +P F Y+V++ + TQ+LQ QA P P+
Sbjct: 1064 AALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 1120
Query: 1033 TYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092
Y L S+ FG+ P +GW+++R D E+ + Y +V A L Q + TV
Sbjct: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVI 1178
Query: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK 1152
V + ++N++SP D FL V E+ P +G++ A D DSG NG+L Y L D K
Sbjct: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF---LLSDGK 1235
Query: 1153 AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFL 1212
F+++P TGE+ LDRE + +++ V V D GSPPR+ T V+V+V D+NDN P F
Sbjct: 1236 FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 1295
Query: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT 1257
Q G L ++V + P LVTT+ AKDPDEG N + Y+++
Sbjct: 1296 QC--LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
Score = 428 bits (1100), Expect = e-119
Identities = 392/1298 (30%), Positives = 567/1298 (43%), Gaps = 137/1298 (10%)
Query: 1337 LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALD-----AASGRLYLA 1391
LT++ EGL P +L+G + A PA D + + LD +G + A
Sbjct: 69 LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
Query: 1392 RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEP 1451
R LD E + + G +++V+++V D N+H+P F D L L + E P
Sbjct: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
Query: 1452 GAALYTFRASDADGPGPNSDVRYRLLR-----QEPPVPALRLDART-GALSAP------- 1498
G A A D D G S Y L++ ++P P +L RT G L +P
Sbjct: 183 GTAFRLPVAHDPDA-GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
Query: 1499 ----------RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS 1548
R LDRE A L +EA D RR +S + V DENDN PVF
Sbjct: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWD---GGRPRRTGLLSVELRVLDENDNPPVFEQ 298
Query: 1549 PS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL-------------ASGGDGHFRL 1594
R + ED PG V A D DLG V Y + A G +F +
Sbjct: 299 DEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAV 358
Query: 1595 HSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT----FQ 1650
+G + V RPLDRE +A H L V A D G+ P AT ++++V DVND P F
Sbjct: 359 EELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418
Query: 1651 QQEYSVLLRENNPPGTSLLTLRATDPDVG------ANGQVTYG-GVSSESFSLDPDTGVL 1703
+ + E PG + + +D D A G++ G G S S SL+ G
Sbjct: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
Query: 1704 TTLRA-------------LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
L LDRE ++ L + A D GSPP T T+ + V D ND P
Sbjct: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
Query: 1751 FGSAHLSLEVPEGQDPQTLTM-LRASDPDVGAN------------------GQLQYRILD 1791
F H V E P T+ M + ASD D + G LQ +++
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
Query: 1792 GDPSG-AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDAND 1850
G +F +D SG T+R LDREV+ A +L++ A+D G+P LSAT L+++TV D ND
Sbjct: 599 TAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658
Query: 1851 HAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-----YLGAGTAGAFLLE 1905
+ P F Y+ + E P G LQ+ A D D+G G + Y +L AF ++
Sbjct: 659 NEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRID 718
Query: 1906 PSSGELRTAAALDREQCP-SYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSP 1964
P G++ + +DRE+ P +Y V A DG G LS V + + DVND+ P F S
Sbjct: 719 PHDGQICVSQDIDRERDPATYDLLVEAKDG---GGLSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 1965 LRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGTPPPGTTVDSYTGEIRVA 2023
+ + P + + A D+D+G ++ Y L G T+DS TG I +
Sbjct: 776 YVTSI----SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLT 831
Query: 2024 RSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP 2083
L L + A D G + + + F R + E+ P
Sbjct: 832 LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
Query: 2084 GTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLV 2143
+PI + +A ++ PI Y I SG+ G FSI P G T+R+ + LD E P + L
Sbjct: 892 DSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLT 949
Query: 2144 LQAESGGAFA--FTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQG 2201
+QA+ G A A T + +T+ D NDN P FLR + ++ P L A+D D G
Sbjct: 950 VQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
Query: 2202 SGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSA 2261
G I YS+A+ QP G+F +D G + L E L L A D+G
Sbjct: 1010 RNGLIRYSIASPQP--GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 1067
Query: 2262 TLTVMVIDTNDNRPTIP---QPWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSP 2315
LTV VI+ ++ P+ +++ VSE +++ Q + + + L Y L P
Sbjct: 1068 VLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
Query: 2316 SGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG---RANLTVLVE--DVN 2370
S F + Y G + L D+E Y ++ A P +G + TV+V D N
Sbjct: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVWDEN 1185
Query: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGT 2430
DN+P F + + + E P I ++A D DSG NG + Y L S F ++PN G
Sbjct: 1186 DNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGE 1245
Query: 2431 LFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL----SH 2486
L + VAL + G ++ + D G+P R A V+V + D ND+ P F
Sbjct: 1246 L---INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 1302
Query: 2487 YRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIIS 2524
V V E P + T+ A D D ++A V YS+ S
Sbjct: 1303 LHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYSVSS 1339
Score = 369 bits (947), Expect = e-101
Identities = 376/1275 (29%), Positives = 535/1275 (41%), Gaps = 139/1275 (10%)
Query: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
F +H TG + R LDRE+R +H V A+ G A + + V DVND +P F
Sbjct: 116 FHVHPDTGIIRTARRLDRERR-DHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPL 169
Query: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP------------- 1698
+ + E +PPGT+ A DPD G Y V DP
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 1699 --------------DTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
+ L LR LDREE L + A D G P + ++V + V DE
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 1745 NDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGA------ 1797
ND+ P F V E P + +RA+D D+G NG ++Y + GA
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 1798 ------FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDH 1851
F ++ SG RPLDRE + QL +EARDGG AT+ +++ VLD ND+
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
Query: 1852 APAFPVPAYS----VEVPEDVPAGTLLLQLQAHDPDAG------ANGHVTYYLGAGTA-- 1899
PA V + V E G + ++ D D A G + LG G+
Sbjct: 410 RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
Query: 1900 ------GAFLLEPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
G F L P L LDRE Y + A D A + PLST ++ +
Sbjct: 470 SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD-AGSPPLSTEETLLLR 528
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRD-AGAN------------ 1996
V D+ND P F + + + P + + A D D AG++
Sbjct: 529 VADLNDQPPLFSQQHYKASVSEA----AAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 1997 -----ASILYRLAGTPP--PGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARS 2049
S+ ++ T P +DS +G I R+ L +VA DLG P S
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 2050 ATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILS 2108
AT ++ + + + P F R ATI E+AP G + A A G G I YS+
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
Query: 2109 G----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLR--LVLQAESGGAFAFTVLTLTLQ 2162
G F I P G I V ++ +D E P LV + GG A + + L+
Sbjct: 705 GFLSYEAPQAFRIDPHDGQICV--SQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE 762
Query: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHV 2222
D NDN P F YV + + ++ V A D D G G ++Y L + LF +
Sbjct: 763 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS-SLFTI 821
Query: 2223 DPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-W 2281
D TTG I T L L++ A D G V +A +T+ + T +P +
Sbjct: 822 DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
Query: 2282 ELRVSEDALLGSEIAQVTGND-VDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE 2340
V ED S I V + ++S ++Y +S FS+ G + PLD E
Sbjct: 882 TFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE 941
Query: 2341 QCDRYQLQLLAHDG--PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398
L + A G P + + V DVNDN PAF ++ ++ + + TPPG+A+
Sbjct: 942 TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
Query: 2399 SATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457
A DRDSG NG I Y +ASP G F++D G LF +LG + + L A D
Sbjct: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTLTLRAEDQ 1058
Query: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSH--YRVAVTEDLPPGSTLLTLEATDADGSRSH 2515
G +AA + V ++ + +H+PS+T H Y+V V+E L P + +L +A R+
Sbjct: 1059 GVHPQAALLVLTVVIE-KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 1117
Query: 2516 AAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA- 2574
+ + YS LEP + A P G + L D+ES YN V A
Sbjct: 1118 SPLRYS-----------LEPSVDSAMFGIRP---YTGWIYLRRQFDYESTQTYNFRVFAW 1163
Query: 2575 ADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPH 2634
Q+ V V V D NDN P F + V E + + A D D G +
Sbjct: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
Query: 2635 G-LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGA-HFALAPV 2692
G L+ F +S G F+++ ++G L ALD E + H++ V D A V
Sbjct: 1224 GQLLYFLLSDGK---FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 1280
Query: 2693 TIEVQDVNDHGPAFPLNL----LSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEA 2748
+ V D+ND+ P FP L L V E QP LVTT+ A D D G + YS+ A
Sbjct: 1281 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
Query: 2749 GPGP-EGREAFALNS 2762
P P +G+ AF S
Sbjct: 1341 RPMPLKGKTAFGKQS 1355
Score = 351 bits (900), Expect = 8e-96
Identities = 386/1338 (28%), Positives = 548/1338 (40%), Gaps = 197/1338 (14%)
Query: 375 VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL----------- 423
V E PP LV I P + G G F D L
Sbjct: 73 VDEGLPPDTLVGDIRAGLPA--------AQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
Query: 424 VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483
+ ARRLDRE RD Y+ V AT G A + V DVND++P F + + +
Sbjct: 125 IRTARRLDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLD-VS 177
Query: 484 EVALPGSFVVRVTARDPDQG-----------------------------TNGQVTYSLAP 514
E++ PG+ A DPD G T G + L P
Sbjct: 178 ELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLP 237
Query: 515 GAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDN 574
G+ + +D + LD E +L + A DGG P +V + + D NDN
Sbjct: 238 GSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 575 EPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA----GLGSSG----- 625
P F++ Y A++ E QPG +V ATD D GP G + YS+ A G GS G
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
Query: 626 SPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPP 683
+ F ++ SG V R LDR+ + V A DGG + V+V ++ D NDN P
Sbjct: 353 AAYFAVEELSGVVRVWRPLDRE-AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
Query: 684 Q----FYPREYAASISAQSPPGTAVLRLRAHDPD-------------------------- 713
F A +S + PG V R+ D D
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSL 471
Query: 714 QGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS 773
+G G + +L G P +F L V PL R + + +L + A D G
Sbjct: 472 EGGEG--DFALLPGGPPGVF-------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 774 ARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPG--------RLAPVT 825
+ + + PP+F Q Y SV E APGT V V A + R V
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 826 LS------------LSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873
LS + + F++D+ SG + T+R LDRE+ V V G PP
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
Query: 874 AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933
A V + +DDVNDN P F + + G + A D DSG+ + ++L
Sbjct: 643 LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSL 702
Query: 934 LAG-----GGGAFTVDPTTGHVRLMRPLGPSGGPA-HELELEARDGGSPPRTSHFRLRVV 987
G AF +DP G + + + + PA ++L +EA+DGG ++ +RV
Sbjct: 703 YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVD 760
Query: 988 VQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSP 1044
++DV P FN TY + T GT+++ V A D G + Y L SS
Sbjct: 761 LEDVNDNH--PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
Query: 1045 FGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI-LNQNEHSP 1103
F ++ +G +++ L L V A G G T V+I + Q +P
Sbjct: 819 FTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDG-----GGLTAVINADVTIHIFQTTLAP 873
Query: 1104 RLSEDP--TFLAVAENQPPGTSVGRVFATD--RDSGPNGRLTYSLQQLSEDSKAFRIHPQ 1159
E P TFL V E+ P + +G V A + S P + Y + K F IHP+
Sbjct: 874 AEFERPKYTFL-VYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGDLGGK-FSIHPR 928
Query: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1219
G + T + LD E Q L VQ Q G +P S+T V++ V+D+NDN P FL+ S
Sbjct: 929 LGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDE-- 985
Query: 1220 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPL 1279
I++ PPGT + +A+D D G NG I Y++ P +F++ G L L
Sbjct: 986 ----IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL 1041
Query: 1280 IRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVP-VVLT 1338
E+ LTL A DQG P++A L L V + + E P+ +V
Sbjct: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-----------EKREHSPSWTFEHLVYQ 1090
Query: 1339 VTAAEGLRP-GSLLGSVAAP--EPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
V +E L P +L + A P L Y+L D F + +G +YL R D
Sbjct: 1091 VEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVD-SAMFGIRPYTGWIYLRRQFD 1149
Query: 1396 FEAGPPWRALTVRAEGP--GGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGA 1453
+E+ + V A P G V V+V DEN+++P F D L L + E+P P
Sbjct: 1150 YESTQTYN-FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG 1208
Query: 1454 ALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLV 1513
+ A D D G N + Y LL +++ TG L LDRE + V
Sbjct: 1209 VIGKITAIDMDS-GKNGQLLYFLLSDG---KFFKMNPNTGELINWVALDREHRGHHEMTV 1264
Query: 1514 EATDRPANASRRRAARVSARVFVTDENDNAPVF-----ASPSRVRLPEDQPPGPAALHVV 1568
TDR S R A ++ V VTD NDN P F V++ E QP V
Sbjct: 1265 LVTDR---GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF 1321
Query: 1569 ARDPDLGEAARVSYRLAS 1586
A+DPD G A V+Y ++S
Sbjct: 1322 AKDPDEGNNAEVTYSVSS 1339
Score = 347 bits (891), Expect = 9e-95
Identities = 391/1334 (29%), Positives = 573/1334 (42%), Gaps = 145/1334 (10%)
Query: 860 VLELEVRAGSGVPPAFAVARVRV-------------LLDDVNDNSPAFPAPEDTVLLPPN 906
+ L + G+PP V +R L + +D+SP D + P+
Sbjct: 66 LFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL----DDFHVHPD 121
Query: 907 TAPGTPIYTLRALDPDSGVN-SRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHE 965
T I T R LD + + S V TLL G V+ V P P
Sbjct: 122 TGI---IRTARRLDRERRDHYSFVAATLL---GAVVQVEIRVNDVNDHSPRFP----LDS 171
Query: 966 LELEARDGGSPPRTSHFRLRVVVQ-DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQA 1024
L+L+ + SPP T+ FRL V D G F++ Y + PS Q
Sbjct: 172 LQLDVSEL-SPPGTA-FRLPVAHDPDAGL------FSTQGYTLVQPSDLPKDPAGPFFQL 223
Query: 1025 QAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQ 1084
+ GP+ L G+SSP LEP L + LDRE + L++ A G + +
Sbjct: 224 RYRTPGPLPSPLLP-GSSSP--LEPLD--LVLLRRLDREEAAAHRLQIEAWDGGRP---R 275
Query: 1085 QTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
+TG +V + +L++N++ P +D AV E+ PG V RV ATDRD GPNG + YS+
Sbjct: 276 RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV 335
Query: 1145 QQLSE-----------DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
+ D+ F + +G V + LDRE Q+ +QL+V+ +DGG+ P
Sbjct: 336 RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVA 395
Query: 1194 TGTVHVAVLDLNDNSPT----FLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPD---- 1245
T V +AVLD+NDN P FL G A +V + PG V + D D
Sbjct: 396 TVRVSIAVLDVNDNRPAIHVLFLTEGGVA------RVSEGARPGDYVARVSVSDADGDWE 449
Query: 1246 -EGENGTILYTLTGPGSELFSLHPHSGE-------------LLTAAPLIRAERPHYVLTL 1291
E E L G GS SL G+ L PL R R Y L L
Sbjct: 450 KEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLL 509
Query: 1292 SAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAER-------DPAAPVPVVLTVTAAEG 1344
A D GSPP S LL++V A L + PP +++ + AAP VV+ V+A++
Sbjct: 510 VATDAGSPPLSTEETLLLRV---ADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDA 566
Query: 1345 LRPGS-----LLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAG 1399
GS V P +G+L +V A+ +FA+D+ SG + R LD E
Sbjct: 567 DEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQ 626
Query: 1400 PPWRALTVRAE-GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTF 1458
V + G A L V + V D N++ P F R + E+ G
Sbjct: 627 EAVELKVVAQDLGEPPLSATCL-VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685
Query: 1459 RASDADGPGPNSDVRYRL----LRQEPPVPALRLDARTGALSAPRGLDRETTPALL-LLV 1513
ASDAD G + Y L L E P A R+D G + + +DRE PA LLV
Sbjct: 686 TASDADS-GLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 743
Query: 1514 EATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVARDP 1572
EA D +A+ RV + D NDN PVF + V + ++ PG ++V+A D
Sbjct: 744 EAKD-----GGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798
Query: 1573 DLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSA 1631
D G V+Y L G F + S+TG + + PL + L V A D G
Sbjct: 799 DSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVI 858
Query: 1632 TQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GG 1688
+T+ + F++ +Y+ L+ E+ P + + T++A +P + ++ + Y G
Sbjct: 859 NADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSG 917
Query: 1689 VSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHA 1748
FS+ P G + T + LD E Q + LTV AQ GS P + V + V D ND+
Sbjct: 918 DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNH 976
Query: 1749 PTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEF 1807
P F + + + P T L + RA D D G NG ++Y I P G F +D A G
Sbjct: 977 PAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVL 1035
Query: 1808 GTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPA--FPVPAYSVEVP 1865
L + L + A D G +A L+LTV V++ +H+P+ F Y VEV
Sbjct: 1036 FLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVS 1094
Query: 1866 EDVPAGTLLLQLQAH--DPDAGANGHVTYYLGAGTAGA-FLLEPSSGELRTAAALDREQC 1922
E + T +LQ QAH P A+ + Y L A F + P +G + D E
Sbjct: 1095 ESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYEST 1153
Query: 1923 PSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
+Y F V A + + +V + V D ND++PTF L L++ P
Sbjct: 1154 QTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEES----PVPQGV 1209
Query: 1983 LATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDR---VLFIV 2039
+ + A D D+G N +LY L + ++ TGE+ + VAL R + ++
Sbjct: 1210 IGKITAIDMDSGKNGQLLYFLL-SDGKFFKMNPNTGEL---INWVALDREHRGHHEMTVL 1265
Query: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI-VSPRAVHA--- 2095
TD G P R+AT + V + + P FP+ + G P+ + V A
Sbjct: 1266 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDP 1325
Query: 2096 -GGTNGPITYSILS 2108
G N +TYS+ S
Sbjct: 1326 DEGNNAEVTYSVSS 1339
Score = 346 bits (888), Expect = 2e-94
Identities = 384/1343 (28%), Positives = 567/1343 (42%), Gaps = 182/1343 (13%)
Query: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
D G PP + V D+ P QQQE S + + LL
Sbjct: 74 DEGLPPDTL-------VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL------------- 113
Query: 1683 QVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742
+ F + PDTG++ T R LDRE ++ + V A G+ Q V + V
Sbjct: 114 ---------DDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVN 158
Query: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLR-ASDPDVGANGQLQYRI-----LDGDPSG 1796
D NDH+P F L L+V E P T L A DPD G Y + L DP+G
Sbjct: 159 DVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
Query: 1797 AFVL-----------DLASGEFGTMRPLD--------REVEPAFQLRIEARDGGQPALSA 1837
F L G + PLD RE A +L+IEA DGG+P +
Sbjct: 219 PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG 278
Query: 1838 TLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--- 1894
L + + VLD ND+ P F Y V ED G + +++A D D G NG V Y +
Sbjct: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
Query: 1895 ---GAGTAGA-------FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV 1944
GAG+ G F +E SG +R LDRE + V A DG A P TV
Sbjct: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATV 397
Query: 1945 SVTITVRDVNDHAPT----FPTSPLRLRLP---RPGPSFSTPTLALAT--LRAEDRDAG- 1994
V+I V DVND+ P F T R+ RPG + +++ A ED G
Sbjct: 398 RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
Query: 1995 -----ANASILYRLAGTP---------PPGTTVDSYTGEIRVARSPVALGPRDRV-LFIV 2039
+ SI L G PPG G P+ RD L +V
Sbjct: 458 LGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEG-------PLDRESRDLYELLLV 510
Query: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV---SPRAVHAG 2096
ATD G P S +++ + ++ P F + +A++ E A PGT ++ + A AG
Sbjct: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
Query: 2097 GTNGPITYSILSGN----------------EKG-TFSIQPSTGAI-TVRSAEGLDFEVSP 2138
+ + Y+++ + E G +F+I +GAI T+R+ LD EV
Sbjct: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
Query: 2139 RLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEA 2195
+ L + A+ G A ++++T+ D NDN P F R Y A + E P+ LQV A
Sbjct: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
Query: 2196 DDLDQGSGGQISYSLA---ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDR 2252
D D G G I YSL S A F +DP G I + +DRE T +L+
Sbjct: 688 SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
Query: 2253 GSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSG--PVL 2309
G L A + V + D NDN P P + +S++ G+EI V D DSG +
Sbjct: 748 GG-GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTV 806
Query: 2310 WYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG---RANLTVLV 2366
Y L P F++ G + LT PL + L + A DG A++T+ +
Sbjct: 807 AYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI 866
Query: 2367 EDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSV 2424
F + Y ++ E P S I +V A + ++ I Y ++S G FS+
Sbjct: 867 FQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSI 925
Query: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL 2484
P GT+ T L H+ V + ++A+ AP + V++ + D ND+ P+F
Sbjct: 926 HPRLGTIRT---RKPLDHETQPVVVLTVQAQLGSAPA-CSSTEVNITVMDVNDNHPAFLR 981
Query: 2485 SHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESA 2544
+ + +++ PPG+ L A D D R+ + YSI S G VF ++
Sbjct: 982 TSDEIRISQTTPPGTALYLARAEDRDSGRN-GLIRYSIASPQPG-VFAID---------- 1029
Query: 2545 GPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPP-VFT 2603
RALG L L L + LT+ A D+G PQ++++ +TV + +P F
Sbjct: 1030 ----RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 1085
Query: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGL-VRFTVSSGDPSGLFELDESSGTLRLA 2662
Y+V V E ++L +A P +R+++ S +F + +G + L
Sbjct: 1086 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 1145
Query: 2663 HALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAENQP 2720
D E+ + V A P T+ V+ D ND+ P F ++L V E+
Sbjct: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 1205
Query: 2721 PGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES 2780
P ++ + AID D+G G+L Y LL G + F +N +TGEL V D EH
Sbjct: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG------KFFKMNPNTGELINWVALDREHRGH 1259
Query: 2781 FRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVF----LAPAFHFQVPEGARRGHSLGH 2834
+ V D G+ + T++V V+ D D P F H +V EG +
Sbjct: 1260 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 1319
Query: 2835 VQATDEDGGADGLVLYSLATSSP 2857
V A D D G + V YS++++ P
Sbjct: 1320 VFAKDPDEGNNAEVTYSVSSARP 1342
Score = 337 bits (864), Expect = 1e-91
Identities = 357/1279 (27%), Positives = 531/1279 (41%), Gaps = 171/1279 (13%)
Query: 1755 HLSLEVPEGQDPQTLTM-----LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGT 1809
+L+L V EG P TL L A+ G+ L D F + +G T
Sbjct: 68 NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127
Query: 1810 MRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVP 1869
R LDRE + L A + + + V D NDH+P FP+ + ++V E P
Sbjct: 128 ARRLDRERRDHYSFVAAT------LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
Query: 1870 AGTLLLQLQAHDPDAGANGHVTYYLGAGT------AGAF--------------LLEPSSG 1909
GT AHDPDAG Y L + AG F LL SS
Sbjct: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
Query: 1910 ELRTA-----AALDREQCPSYTFSVSAVDGAAAGPLST-TVSVTITVRDVNDHAPTFPTS 1963
L LDRE+ ++ + A DG P T +SV + V D ND+ P F
Sbjct: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR--PRRTGLLSVELRVLDENDNPPVFEQD 299
Query: 1964 PLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT------------ 2011
R + + P + +RA DRD G N + Y + PG
Sbjct: 300 EYRAAVRED----AQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY 355
Query: 2012 -TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPR--- 2067
V+ +G +RV R L + A D G AT + + + + P
Sbjct: 356 FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
Query: 2068 -FPRASSEATIRENAPPGTPIVSPRAVHAGGT----------------NGPITYSILSGN 2110
F A + E A PG + A G +G I+ S+ G
Sbjct: 416 LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG- 474
Query: 2111 EKGTFSIQPS--TGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV---LTLTLQDAN 2165
+G F++ P G + LD E L+L A G+ + L L + D N
Sbjct: 475 -EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
Query: 2166 DNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG------------------GQIS 2207
D P F + HY A + E+ ++ V A D D+ G +
Sbjct: 534 DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
Query: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267
+ + F +D +G I+T LDRE+ L ++A D G P L + +++ V
Sbjct: 594 SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
Query: 2268 IDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWY-------VLSPSGPQ 2319
D NDN P Q + ++E A +G QVT +D DSG + LS PQ
Sbjct: 654 DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
Query: 2320 DPFSVGRYGGRVSLTGPLDFEQCDR-YQLQLLAHDGPH-EGRANLTVLVEDVNDNAPAFS 2377
F + + G++ ++ +D E+ Y L + A DG +A + V +EDVNDN P F+
Sbjct: 714 -AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFN 772
Query: 2378 QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL--ASPADGFSVDPNNGTLFTIV 2435
S Y + + T PG+ I++V ATD+DSG G ++Y L + + F++D G ++
Sbjct: 773 PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL-- 830
Query: 2436 GTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDL 2495
T+ L H S + +++ A+D G A V + + F Y V ED+
Sbjct: 831 -TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
Query: 2496 PPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLV 2555
P S + T++A + S + Y I SG+ G F + PRL G +
Sbjct: 890 PEDSPIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRL--------------GTIR 933
Query: 2556 LLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615
+PLD E+ LTV A G P S V +TV+DVNDN P F R S + + + T
Sbjct: 934 TRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675
P G L A D D G +GL+R++++S P G+F +D + G L L +L Q L
Sbjct: 993 PPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTL 1051
Query: 2676 VVQAADPAGAH--FALAPVTIEVQDVNDHGPAFPLNLL--STSVAENQPPGT--LVTTLH 2729
++A D G H AL +T+ ++ +H P++ L V+E+ P T L T H
Sbjct: 1052 TLRAEDQ-GVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
Query: 2730 AIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES--FRLLVGA 2787
+ G A LRYSL P + F + TG + R FDYE T++ FR+
Sbjct: 1110 PL-GPQRAASPLRYSL---EPSVDSA-MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
Query: 2788 ADAGNL-SASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADG 2846
+ G L + S TV V V E++ P FL +V E +G + A D D G +G
Sbjct: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
Query: 2847 LVLYSLATSSPYFGINQTTGAL--YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA 2904
+LY L + +F +N TG L ++ +D G E+ + V
Sbjct: 1225 QLLYFLLSDGKFFKMNPNTGELINWVALDREHRGH----------------HEMTVLVTD 1268
Query: 2905 RGPLPGSRSATVPVTVDIT 2923
RG P R+AT+ V V +T
Sbjct: 1269 RGSPP--RNATMAVYVSVT 1285
Score = 165 bits (418), Expect = 6e-40
Identities = 178/660 (26%), Positives = 272/660 (41%), Gaps = 52/660 (7%)
Query: 94 IDEHSGVVRTARVLDREQRDR-YRFTAVTPDG----ATVEVTVRVADINDHAPAFPQARA 148
ID H G + ++ +DRE+ Y DG A V V + D+ND+ P F +
Sbjct: 717 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTY 776
Query: 149 ALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELV 208
+ + T GT A D D+G GT Y L F +++ G +
Sbjct: 777 VTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGI-------IY 829
Query: 209 VTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESL 268
+T L + L + A DGG A + + + F + +Y +V E +
Sbjct: 830 LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
Query: 269 APGSPVLQVFASDADAGVNGAVTYEINRRQSEGD--GPFSIDAHTGLLQLERPLDFEQRR 326
SP+ V A + + + Y I S GD G FSI G ++ +PLD E +
Sbjct: 890 PEDSPIGTVKAREP-LNSSEPIFYRI----SSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
Query: 327 VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386
V L VQA+ G A P S V + V D NDN P+ FL ++S+ PPG +
Sbjct: 945 VVVLTVQAQLGSA-PACSSTEVNITVMDVNDNHPA----FLRTSDEIRISQTTPPGTALY 999
Query: 387 RISVSDPDDGDFAHVNVSLEGGE-GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
D D G + S+ + G FA+ V++L L E+ L + A
Sbjct: 1000 LARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTLTLRAE 1056
Query: 446 DSGSPPLRAEAAFVLHVTDVNDNAPA--FDRQLYRPEPLPEVALPGSFVVRVTARD-PDQ 502
D G P A + V + +++P+ F+ +Y+ E + E P + +++ A Q
Sbjct: 1057 DQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE-VSESLSPMTQMLQTQAHPLGPQ 1114
Query: 503 GTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVA---TDGGLPPLA 559
+ YSL P + F I P +G I DYE V A DG L +
Sbjct: 1115 RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV- 1173
Query: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619
S TV V + D NDN P F + E P ++TA D DSG G L Y L
Sbjct: 1174 -STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL-- 1230
Query: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--D 677
S F+++ ++G++ LDR+ + TV D G + V++S D
Sbjct: 1231 ---LSDGKFFKMNPNTGELINWVALDREHR-GHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
Query: 678 ENDNPPQFYP-----REYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPL 732
NDN P F+P +E + P V + A DPD+G++ ++Y + + PL
Sbjct: 1287 INDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
Score = 32.3 bits (72), Expect = 8.0
Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 4/154 (2%)
Query: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
G + L L+ SV E PP TLV + A A + L E + F ++
Sbjct: 61 GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
Query: 2763 STGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQV 2822
TG +R D E + + + A L A V V + V +++ P F + V
Sbjct: 121 DTGIIRTARRLDRERRDHYSFVA----ATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
Query: 2823 PEGARRGHSLGHVQATDEDGGADGLVLYSLATSS 2856
E + G + A D D G Y+L S
Sbjct: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 802 bits (2072), Expect = 0.0
Identities = 768/2772 (27%), Positives = 1204/2772 (43%), Gaps = 206/2772 (7%)
Query: 49 LQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
L++ E+ P GT++ + A P G A + Y + G +D +G + R L
Sbjct: 932 LKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLM----DGAHGTFRVDLMTGALILEREL 987
Query: 108 DREQRDRYRFTAVTPDGAT-------VEVTVRVADIND--HAPAFPQARAALQVPEHTAF 158
D E+R Y + DG V V V D+N+ H P F QV E++
Sbjct: 988 DFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPS 1047
Query: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
GT+ + A+D D+G G Y L F + G T P LDRE
Sbjct: 1048 GTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP-------LDREFA 1100
Query: 219 SHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVF 278
S+Y L + A D GS P + + + + D ND+ P +Q+ ++ + E G+ VLQ+
Sbjct: 1101 SYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
Query: 279 ASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGG 338
A D D+ G +T+ I G F I TGLL + LD E + H L V D G
Sbjct: 1161 AWDPDSSSKGKLTFNITSGNYMGF--FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNG 1218
Query: 339 AHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF 398
++ V V + D NDN P + + ++S +P V R+ SD D+G
Sbjct: 1219 EPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP--VYRLVASDLDEGLN 1276
Query: 399 AHVNVSLEGG-EGHFALSTQDSVIYLVCVARRLDREERDAYN-LRVTATDSGSPPLRAEA 456
V S+E E F++ D V +V + E YN L + ATDSG PPL A
Sbjct: 1277 GRVTYSIEDSDEEAFSI---DLVTGVVSSSSTFTAGE---YNILTIKATDSGQPPLSASV 1330
Query: 457 AFVLHVTDVNDNAP-----AFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS 511
LH+ + P AFD Y + P + +V V + + G G ++
Sbjct: 1331 R--LHIEWIPWPRPSSIPLAFDETYYSFTVMETD--PVNHMVGVISVE---GRPGLFWFN 1383
Query: 512 LAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV 571
++ G F I+ T+G I A LD L V TDG +A+ + + + ++
Sbjct: 1384 ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT-IATQVHIFM-IANI 1441
Query: 572 NDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI 631
N + PQF T Y +P+ T PG L+V A D D G L Y++ + F++
Sbjct: 1442 NHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQL 1499
Query: 632 DAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPRE 689
D SG + T LD GPS TV D ++ V+V + + D N +PP+F
Sbjct: 1500 DPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLH 1559
Query: 690 YAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLA 749
Y AS+ PGT +L++RA D D+G + + Y +L GNS F ++ G++T+A L
Sbjct: 1560 YEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
Query: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSV 809
+ ++ L + AED G Q A V I + P + PIF + +Y +PE + G+ +
Sbjct: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
Query: 810 GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGS 869
+V A +P + VT L G+ G+FS+++ SGL+ T + LD E + +L++R GS
Sbjct: 1680 LLVSAMSP----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISS-YQLKIR-GS 1733
Query: 870 GVPPAFAVARVRVLLDDVNDNSPAF-----------PAPEDTVLLPPNTAPGTPIYTLRA 918
+ AF V V + D NDN+P F AP ++++ N P + + A
Sbjct: 1734 NMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP----FVIHA 1789
Query: 919 LDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPP 977
D D NS + + +L F +DP+ G + ++ + P+ + + D GSP
Sbjct: 1790 SDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPV 1849
Query: 978 RTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLA 1037
+ +V++ PRF+ Y V + G ++L V+A D + Y +
Sbjct: 1850 LFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED-SEVNYSIK 1908
Query: 1038 AEGASSPFGLEPQSGWLWV-RAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSIL 1096
A + P +G + V A +++L I +A G TA V++S+
Sbjct: 1909 TGNADEAVTIHPVTGSISVLNPAFLGLSRKLTI---------RASDGLYQDTALVKISLT 1959
Query: 1097 NQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRI 1156
+ S + +D + AV EN ++ V + + N L+Y L + F +
Sbjct: 1960 QVLDKSLQFDQDVYWAAVKENLQDRKAL--VILGAQGNHLNDTLSYF---LLNGTDMFHM 2014
Query: 1157 HPQTGEVTTL-QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQAS 1215
G + T DREQQ +++L V+V+D +P R G V V++ D+NDN P F
Sbjct: 2015 VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKH-- 2072
Query: 1216 GAAGGGLPIQ--VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
LP + D PG ++ + A D D G NG + Y F + P+ G++
Sbjct: 2073 ------LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-AEDYTYFRIDPYLGDI 2125
Query: 1274 LTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDP---A 1330
P Y L + A D G+P + ++LV V + P R P
Sbjct: 2126 SLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENIT 2185
Query: 1331 APVPVVLT-VTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLY 1389
P++ T + EGLR L Y +V +P F D +G L
Sbjct: 2186 LYTPILHTQARSPEGLR------------------LIYNIV-EEEPLMLFTTDFKTGVLT 2226
Query: 1390 LARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENP 1449
+ PLD+E+ TVRA V+V V+D N++ P F++ ++ E
Sbjct: 2227 VTGPLDYESKTK-HVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGL 2285
Query: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPA-LRLDARTGALSAPRGLDRETTPA 1508
+ ASD D G N DV Y+++ V +++ TG +S + LD E
Sbjct: 2286 PAQTPVIQLLASDQDS-GRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQH 2344
Query: 1509 LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHV 1567
+ V A D+ V V+D NDN P F P + E G L V
Sbjct: 2345 FHVKVRAMDK---GDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKV 2401
Query: 1568 VARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGS 1626
A DPD + +R+ Y + SG D HF ++SS+G +S+ + + + L V ASD
Sbjct: 2402 QAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD--- 2458
Query: 1627 PPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY 1686
AT + ++ + N +P FQQ Y L EN GT ++ L A D D G G + Y
Sbjct: 2459 GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDY 2518
Query: 1687 ---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVED 1743
++SE FS++P+ G + TL+ LDRE E + + R ++ TV++ + D
Sbjct: 2519 TIINKLASEKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTD 2577
Query: 1744 ENDHAPTFGSAH--LSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGD-PSGAFVL 1800
END+ P F ++ +S++ +D + +L A D D G N + Y + D +
Sbjct: 2578 ENDNPPQFKASEYTVSIQSNVSKDSPVIQVL-AYDADEGQNADVTYSVNPEDLVKDVIEI 2636
Query: 1801 DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1860
+ +G L I+A+DGG P ++ + + + V+ P F P Y
Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLY 2696
Query: 1861 SVEVPEDVPAGT---LLLQLQAHDPDAGANGHVTYYLGAGTA------GAFLLEPSSGEL 1911
+ PED+P G+ ++ + A DP V Y L GT G F L+P +G +
Sbjct: 2697 TFSAPEDLPEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Query: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
+ +D E Y V A + + VSV I V DVND+ P F P + L
Sbjct: 2750 KVRKPMDHESTKLYQIDVMA-HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTE 2808
Query: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT----TVDSYTGEIRVARSPV 2027
P + ++ + A D+D G + + YRL+ P +DS +G I +
Sbjct: 2809 NMPVGT----SVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELD 2864
Query: 2028 ALGPRDRVLFIVATDLGRPAR-SATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTP 2086
+ +VA D G+ + S+ ++ V + E + PRF ++ EN+ PG
Sbjct: 2865 CETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGEL 2924
Query: 2087 IVSPRAVHA--GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL 2144
+ + + + A N +T I G+ G F I + S + LD E + + L +
Sbjct: 2925 VATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRV 2984
Query: 2145 QAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGG 2204
A G A + + + D NDN+P+ + Y + E +L+V A DLD +
Sbjct: 2985 TASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNA 3044
Query: 2205 QISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLT 2264
QI+YSL P F +DP TG +TT LDRE LV ATD G + A +T
Sbjct: 3045 QITYSLHG--PGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSC--QADIT 3100
Query: 2265 VMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLS-PSGPQDPF 2322
+ V D NDN P P + V ++ + + +A V D D G V S P + F
Sbjct: 3101 LHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHF 3160
Query: 2323 SVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----GPHEGRANLTVLVEDVNDNAPAFSQ 2378
S+ G + L PL +L + A D P +TV V + D P F
Sbjct: 3161 SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
Query: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTV 2438
+ + V + E PPG+ +L ++ R + F +D G L+
Sbjct: 3221 TEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYV---NA 3277
Query: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
+L + S + +E + + TV V + D N+H P F Y V E+ G
Sbjct: 3278 SLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVG 3337
Query: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
+LT+ ATD DG ++ + YS+I GN F + P+ E L + +
Sbjct: 3338 DVILTVSATDEDGP-LNSDITYSLIGGNQLGHFTIHPKKGE--------------LQVAK 3382
Query: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
LD E + Y+L + A D GQPP + + V DVNDNPP F + +Y TV E++P+G
Sbjct: 3383 ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIG 3442
Query: 2619 AELLHVEASDADPGPHG-LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVV 2677
+++L + SD D +G F ++ G+ F + G L A L Q +QL +
Sbjct: 3443 SKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQI 3501
Query: 2678 QAADPAGAHF-ALAPVTIEVQDVNDHGP-AFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
QA+D +L V + V + + + P A PL + T V E++ G +V +HA D D
Sbjct: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFIT-VGEDEFQGGMVGKIHATDRDP 3560
Query: 2736 GAFGRLRYSLLE 2747
L YSL E
Sbjct: 3561 Q--DTLTYSLAE 3570
Score = 775 bits (2001), Expect = 0.0
Identities = 822/2986 (27%), Positives = 1295/2986 (43%), Gaps = 260/2986 (8%)
Query: 49 LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLD 108
+Q+ E P G+ + + A P + ++ VG L + +G++ T +++D
Sbjct: 369 VQLSEFSPPGSRVVMVRVT----PAFPNLQYVLKPSSENVGFKL--NARTGLITTTKLMD 422
Query: 109 REQRDRYRFTAVTPDG-ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPA 167
R Y+ T G A+ V + + D N+HAP F ++ + E+ GT A
Sbjct: 423 FHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTA 482
Query: 168 RDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRE-NRSHYMLQLE 226
D D G G Y+++G A F ++ G T P +D E + Y ++
Sbjct: 483 TDRDHGENGYVTYSIAGPKA-LPFSIDPYLGIISTSKP-------MDYELMKRIYTFRVR 534
Query: 227 AYDGGSPPRRAQAL-LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAG 285
A D GSP RR + + + + L ++ND+ P F + + + G ++ + A D D
Sbjct: 535 ASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDEL 594
Query: 286 VNGAVTYEI-NRRQSEGDGPFSIDAHTGLLQLERP---LDFEQRRVHELVVQARDGGAHP 341
N + YEI + + E F ++ +G++ L+RP L Q + L + A DG +
Sbjct: 595 QN--LKYEIVSGNELE---YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYA 649
Query: 342 ELGSAFVTVHVRDAN--------------------------DNQPSMTVIFLS------- 368
+ +TV V+D + NQ S F S
Sbjct: 650 SPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQIN 708
Query: 369 ------ADGSPQ---VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQ 417
D PQ V E+ P +AR++ +DPD G + + G EG F + +
Sbjct: 709 HYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELE 768
Query: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
L+ VA LD E + Y L VT D G+P + ++V D NDNAP F Y
Sbjct: 769 TG---LLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825
Query: 478 RPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLD 537
+ + E G+ + +T +D D NG+V Y+L + T FS+ P +G + LD
Sbjct: 826 Q-LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLD 882
Query: 538 YELEPQPQLIVVATDGGLP--PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGT 595
E EP+ L V A D L S + + L+DVNDN PQ +PE PGT
Sbjct: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942
Query: 596 CFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF 655
+ A+D D GP G + Y L G + FR+D +G + R LD ++ + ++
Sbjct: 943 VLTFLDASDPDLGPAGEVRYVLMDGAHGT----FRVDLMTGALILERELDFER-RAGYNL 997
Query: 656 TVTAVDGG---GLKSMVYVKVFLSDENDN--PPQFYPREYAASISAQSPPGTAVLRLRAH 710
++ A DGG +++ +V+V + D N+N PP F + + SP GT V+ + A
Sbjct: 998 SLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQ 1057
Query: 711 DPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQA 770
D D G G L Y + AG F++++ +G++ PL R S L + A D G +
Sbjct: 1058 DDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL 1117
Query: 771 EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP-PGRLAPVTLSLS 829
V I + PP Q + S+ ED GTSV + A +P +T +++
Sbjct: 1118 SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT 1177
Query: 830 GGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELEVRAGSGVPPAFAVARVRVLLDDVN 888
G+ G F + V+GLL T + LDRE +LE+ V +G P + +RV V + DVN
Sbjct: 1178 SGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LDNGEPSLKSTSRVVVGILDVN 1236
Query: 889 DNSPAFPAPEDTVLLPPNTAPGT--PIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPT 946
DN P F V LP +P + P+Y L A D D G+N RVT+++ AF++D
Sbjct: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLV 1296
Query: 947 TGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYR 1006
TG V + G + L ++A D G PP ++ RL + P TY
Sbjct: 1297 TGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYY 1354
Query: 1007 VDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQE 1066
T ++ V + G ++++ F +E +G + + LD +
Sbjct: 1355 SFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRS 1414
Query: 1067 LYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR 1126
Y L V GS+ T I N N H P+ E + V ++ PG + R
Sbjct: 1415 NYNLTVEVTDGSRT-----IATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
Query: 1127 VFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD-REQQSSYQLLVQVQD 1185
V A D+D G + T Q + F++ P +G + T+ LD S + L V V+D
Sbjct: 1470 VQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
Query: 1186 GGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPD 1245
P + V + V D N + P F Q A VPD + PGT + ++A D D
Sbjct: 1530 QEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEA------SVPDTIAPGTELLQVRAMDAD 1583
Query: 1246 EGENGTILYTLTGPGSE-LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSAS 1304
G N + Y+L SE F+++ G + A L +A + LT+ A DQGSP
Sbjct: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDL 1643
Query: 1305 LQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGA 1364
+++ V PS R A P ++ + +P E + GS + V+A P+ V
Sbjct: 1644 ATVIIHVYPSDRSA---PIFSKSEYFVEIP--------ESIPVGSPILLVSAMSPSEV-- 1690
Query: 1365 LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQV 1424
TY L G + +G F++++ SG + + LD E ++ L +R GA ++ V V
Sbjct: 1691 -TYELREG-NKDGVFSMNSYSGLISTQKKLDHEKISSYQ-LKIRGSNMAGAFTDVM-VVV 1746
Query: 1425 QVQDENEHAPAFARD----------PL-ALALPENPEPGAALYTFRASDADGPGPNSDVR 1473
+ DEN++AP F + PL ++ + +N P + ASD+D NS +
Sbjct: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP----FVIHASDSDKEA-NSLLV 1801
Query: 1474 YRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR--PANASRRRAARVS 1531
Y++L E + ++D G L+ +D E+ P+ V D+ P + R A +
Sbjct: 1802 YKILEPE-ALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVI- 1859
Query: 1532 ARVFVTDENDNAPVFASP-SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG-GD 1589
+ V D ND+ P F+ V + PG L V A D D + V+Y + +G D
Sbjct: 1860 --IHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNAD 1913
Query: 1590 GHFRLHSSTGALSVVRP----LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDE 1645
+H TG++SV+ P L R+ LT+ ASD T ++ +S+ V D+
Sbjct: 1914 EAVTIHPVTGSISVLNPAFLGLSRK------LTIRASD---GLYQDTALVKISLTQVLDK 1964
Query: 1646 APTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS-SESFSLDPDTGVLT 1704
+ F Q Y ++EN +L+ L A + N ++Y ++ ++ F + GVL
Sbjct: 1965 SLQFDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYFLLNGTDMFHMVQSAGVLQ 2022
Query: 1705 TLR-ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEG 1763
T A DRE+Q+ L V +D +P ++ VRV++ED ND+ P F + +G
Sbjct: 2023 TRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDG 2082
Query: 1764 QDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQ 1822
+P L + A+D D+G NG + Y + F +D G+ +P D + +
Sbjct: 2083 TEPGDVLFQVSATDEDLGTNGAVTYEF--AEDYTYFRIDPYLGDISLKKPFDYQALNKYH 2140
Query: 1823 LRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP 1882
L++ ARDGG P+L + + VTV N P F P Y V VPE++ T +L QA P
Sbjct: 2141 LKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSP 2198
Query: 1883 DAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLST 1942
+ + + F + +G L LD E + F+V A D A
Sbjct: 2199 E--GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA 2256
Query: 1943 TVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
TV V V DVND+ PTF + P+ TP + L A D+D+G N + Y+
Sbjct: 2257 TVEV--LVEDVNDNPPTFSQLVYTTSISEGLPA-QTPVIQLL---ASDQDSGRNRDVSYQ 2310
Query: 2003 LAGTPPPGTTVDSY------TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIV 2056
+ G+ V + TGE+ + + + + A D G P + +++V
Sbjct: 2311 IV---EDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVV 2367
Query: 2057 GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTN-GPITYSILSGNEKGTF 2115
+ + P F + EA + E A G ++ +A+ + + Y ILSGN+ F
Sbjct: 2368 NVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHF 2427
Query: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV-LTLTLQDANDNAPRFLRP 2174
I S+G I++ + + S LR+ S G F TV + + +AN +P F +
Sbjct: 2428 FINSSSGIISMFNLCKKHLDSSYNLRV---GASDGVFRATVPVYINTTNANKYSPEFQQH 2484
Query: 2175 HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAI 2234
Y A L E+ + ++ + A D D G G I Y++ ++ A F ++P G I T
Sbjct: 2485 LYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI-INKLASEKFSINP-NGQIATLQK 2542
Query: 2235 LDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGS 2293
LDRE E + + R V T+ +++ D NDN P + + + + S
Sbjct: 2543 LDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDS 2602
Query: 2294 EIAQVTGNDVDSG---PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350
+ QV D D G V + V +D + G V + L + +
Sbjct: 2603 PVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIK 2662
Query: 2351 AHDG--PH-EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGA 2407
A DG PH + + V + P FS+ LY E P GS I V A A
Sbjct: 2663 AQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AA 2718
Query: 2408 NGHISYHLA------SPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
+ Y L S DG FS+DP+ G I + H+ + + + A
Sbjct: 2719 QDPVIYSLVRGTTPESNKDGVFSLDPDTG---VIKVRKPMDHESTKLYQIDVMAHCLQNT 2775
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
+ +V++Q+ D ND+ P F Y+ +TE++P G++++ + A D D R V Y
Sbjct: 2776 DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD-GQVSY 2834
Query: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580
+ + V +L A ES G + L+ LD E+ Y+ V A D GQ
Sbjct: 2835 RLSADPGSNVHEL---FAIDSES--------GWITTLQELDCETCQTYHFHVVAYDHGQT 2883
Query: 2581 PQ-SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHG-LVR 2638
Q SS V V++ D NDN P F YR +V E++ G + ++ DAD V
Sbjct: 2884 IQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVT 2943
Query: 2639 FTVSSGDPSGLFELDESSGTLRLA--HALDCETQARHQLVVQAADPAGAHFALAPVTIEV 2696
++ GDP G F + + R++ LD E A++ L V A+D G A V I V
Sbjct: 2944 CYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD--GKFQASVTVEIFV 3001
Query: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
DVND+ P L + V E+ PG + + A D D ++ YSL GP G
Sbjct: 3002 LDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL--HGP---GAH 3056
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAP 2816
F L+ TGEL D E + F L+ A D G S +++ V ++ P F
Sbjct: 3057 EFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPS 3116
Query: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSP-YFGINQTTGALYLRVDSR 2875
V + + V A D D GA+ V+YSL S+ +F I+ TTG + L
Sbjct: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPL- 3175
Query: 2876 APGSGTATSGGGGRTRREAPRELRLEVIARG-PLPGSRSATVPVTV 2920
+ R +AP EL + G P+P S TV V+V
Sbjct: 3176 -------------QVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208
Score = 770 bits (1989), Expect = 0.0
Identities = 782/2837 (27%), Positives = 1230/2837 (43%), Gaps = 222/2837 (7%)
Query: 107 LDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEP 166
L ++ FT+++ T ++ DH FPQ+ + V E T
Sbjct: 689 LQNQESSDEEFTSLS----TYQINHYTPQFEDH---FPQS---IDVLESVPINTPLARLA 738
Query: 167 ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLE 226
A D DAG G Y ++ F +E G L V LD E + Y+L +
Sbjct: 739 ATDPDAGFNGKLVYVIADGNEEGCFDIELETGL-------LTVAAPLDYEATNFYILNVT 791
Query: 227 AYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGV 286
YD G+P + + LL V + D ND+AP F Y +SE G+ + ++ DAD+
Sbjct: 792 VYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSED 851
Query: 287 NGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARD--GGAHPELG 344
NG V Y + + FS+ TG L + LD E + L V+ARD H
Sbjct: 852 NGRVRYTLLSPTEK----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
Query: 345 SAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVN-V 403
+ + + D NDN P ++ +V E PPG ++ + SDPD G V V
Sbjct: 908 VTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV 963
Query: 404 SLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHV 462
++G G F + + L R LD E R YNL + A+D G P R V + V
Sbjct: 964 LMDGAHGTFRVDLMTGALIL---ERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV 1020
Query: 463 TDVNDNA-PAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWF 521
DVN+N P + E + G+ V+ V A+D D G +G++ Y L G F
Sbjct: 1021 LDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF 1080
Query: 522 SIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
SI+ +G+I T A LD E L V+A D G PL+S V + + D NDN PQ +
Sbjct: 1081 SINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQA 1140
Query: 582 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTT 641
+ S+ E GT LQ+ A D DS G L++++ +G + F I +G + T
Sbjct: 1141 VFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTA 1197
Query: 642 RTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSP 699
+ LDR+ VT +D G LKS V V + D NDNPP F + + + +
Sbjct: 1198 QQLDRENKDEHI-LEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLS 1256
Query: 700 PGT--AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQ 757
P + V RL A D D+G +GR++Y I + F++D +G+++ + ++
Sbjct: 1257 PVSPGPVYRLVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTGVVSSSSTFTAGEYNI-- 1313
Query: 758 LEIGAEDGGGLQAEPSARVDISIVP---GTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA 814
L I A D G S R+ I +P + P F++ Y F+V E VG++
Sbjct: 1314 LTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV 1373
Query: 815 HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLD-RELLGPVLELEVRAGSGVPP 873
PG ++SGGD F ++ +G + RPLD R L +EV GS
Sbjct: 1374 EGRPGLF---WFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT-- 1428
Query: 874 AFAVARVRV-LLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTF- 931
+V + ++ ++N + P F V +P +T PG + ++A+D D G + T
Sbjct: 1429 --IATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIH 1486
Query: 932 -TLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPA-HELELEARDGGSPPRTSHFRLRVVVQ 989
+ G F +DP++G + + L GP+ H L + RD P + + + + V+
Sbjct: 1487 GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE 1546
Query: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFG 1046
D PRF Y +P GT++LQV+A D G + Y L + F
Sbjct: 1547 DGNLH--PPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
Query: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
+ G + + LD+ + L V A Q ATV + + + +P S
Sbjct: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSP---QWHDLATVIIHVYPSDRSAPIFS 1661
Query: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL 1166
+ F+ + E+ P G+ + V A +TY L++ ++D F ++ +G ++T
Sbjct: 1662 KSEYFVEIPESIPVGSPILLVSAMS-----PSEVTYELREGNKDG-VFSMNSYSGLISTQ 1715
Query: 1167 QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV 1226
+ LD E+ SSYQL +++ T V V ++D NDN+P FL+++ Q+
Sbjct: 1716 KKLDHEKISSYQL--KIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVG------QI 1767
Query: 1227 PDRVPPGTLVT-------TLQAKDPDEGENGTILYTLTGPGS-ELFSLHPHSGELLTAAP 1278
+ P +++ + A D D+ N ++Y + P + + F + P G L +
Sbjct: 1768 SEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE 1827
Query: 1279 LIRAERPHYVLTLSAHDQGSP----PRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVP 1334
+ P + + HDQGSP PR A Q+++ V + + PP +E+
Sbjct: 1828 MDYESMPSFQFCVYVHDQGSPVLFAPRPA--QVIIHV---RDVNDSPPRFSEQ------- 1875
Query: 1335 VVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTL-VGGADPEGTFALDAASGRLYLARP 1393
+ V + PG L V A + + Y++ G AD T + +G + + P
Sbjct: 1876 -IYEVAIVGPIHPGMELLMVRASDED--SEVNYSIKTGNADEAVT--IHPVTGSISVLNP 1930
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQV-QVQDENEHAPAFARDPLALALPENPEPG 1452
R LT+RA L+++ + QV D++ F +D A+ EN +
Sbjct: 1931 AFLGLS---RKLTIRASDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKENLQDR 1984
Query: 1453 AALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL--DRETTPALL 1510
AL A G N + Y LL + G L RG+ DRE
Sbjct: 1985 KALVIL---GAQGNHLNDTLSYFLLN---GTDMFHMVQSAGVLQT-RGVAFDREQQDTHE 2037
Query: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPEDQPPGPAALHVVA 1569
L VE D N + +R A+ RV + D NDN P F P + + PG V A
Sbjct: 2038 LAVEVRD---NRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSA 2094
Query: 1570 RDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR 1629
D DLG V+Y A +FR+ G +S+ +P D + ++ L V+A D G+P
Sbjct: 2095 TDEDLGTNGAVTYEFAEDYT-YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSL 2153
Query: 1630 SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV 1689
+ + + V+V N P FQ Y V + EN T +L +A P+ ++ Y V
Sbjct: 2154 QSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE---GLRLIYNIV 2208
Query: 1690 SSES---FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
E F+ D TGVLT LD E + + TV A D + + TV V VED ND
Sbjct: 2209 EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT-ALGSFSEATVEVLVEDVND 2267
Query: 1747 HAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILD--GDPSGAFVLDLA 1803
+ PTF + + EG QT + L ASD D G N + Y+I++ D S F ++ +
Sbjct: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGS 2327
Query: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVE 1863
+GE T++ LD E + F +++ A D G P L+ L+ V V D ND+ P F P Y
Sbjct: 2328 TGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEAN 2387
Query: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA-FLLEPSSGELRTAAALDREQC 1922
V E G L+L++QA DPD+ + Y + +G F + SSG + +
Sbjct: 2388 VSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD 2447
Query: 1923 PSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
SY V A DG TV V I + N ++P F L T +
Sbjct: 2448 SSYNLRVGASDGV----FRATVPVYINTTNANKYSPEFQQHLYEAELAE-NAMVGTKVID 2502
Query: 1983 LATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATD 2042
L + D+D+G +I Y + + G+I + +RV+ I
Sbjct: 2503 LLAI---DKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMA 2559
Query: 2043 LGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGP 2101
R A + + L E + P+F + +I+ N +P++ A A G N
Sbjct: 2560 RDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
Query: 2102 ITYSILSGN-EKGTFSIQPSTGAITVR-SAEGLDFEVSPRLRLVLQAESGGAFAFTVLT- 2158
+TYS+ + K I P TG + V+ S GL+ + L ++A+ GG + L
Sbjct: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLE---NQTLDFFIKAQDGGPPHWNSLVP 2676
Query: 2159 --LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPA 2216
L + + P+F P Y PE P + V+A + + YSL
Sbjct: 2677 VRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA----VAAQDPVIYSLVRGTTP 2732
Query: 2217 R----GLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
G+F +DP TG I +D E ++ +MA + +V ++ + V D ND
Sbjct: 2733 ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
Query: 2273 NRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSP---SGPQDPFSVGR 2326
NRP P++ ++E+ +G+ + QVT D D+G + Y LS S + F++
Sbjct: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDS 2852
Query: 2327 YGGRVSLTGPLDFEQCDRYQLQLLAHDGPH----EGRANLTVLVEDVNDNAPAFSQSLYQ 2382
G ++ LD E C Y ++A+D +A + V + D NDNAP F+ Y+
Sbjct: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR 2912
Query: 2383 VMLLEHTPPGSAILSVSATDRD-SGANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVA 2439
++E++ PG + ++ D D S N ++ ++ P F + G + I
Sbjct: 2913 GSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGIS-QVGDEWRISSRKT 2971
Query: 2440 LGHDGSGAVDVVLEARDHGAPGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
L + + + + A D G+ A TV + + D ND++P + Y V ED+ PG
Sbjct: 2972 LDREHTAKYLLRVTASD----GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
Query: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
+L + ATD D + ++A + YS + G F+L+P E L L
Sbjct: 3028 HFILKVSATDLD-TDTNAQITYS-LHGPGAHEFKLDPHTGE--------------LTTLT 3071
Query: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
LD E +NL A D G +S +T+ V DVNDN P F + V V ++T V
Sbjct: 3072 ALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVK 3129
Query: 2619 AELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
+ V A D D G + V +++ G F +D ++G +RL L QA +L V+
Sbjct: 3130 TPVAVVFARDPDQGANAQVVYSLPD-SAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
Query: 2679 AADPAGAHF---ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
A+D G L VT+ V + D+ P F S V E+ PPGT V L +
Sbjct: 3189 ASD-LGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP- 3246
Query: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAA--DAGNL 2793
G + +GR F L++ TG L D+E + + L + + + +L
Sbjct: 3247 ---GAEKTGYRVVSGNEQGR--FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSL 3301
Query: 2794 SASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLA 2853
S TV V +T +E+ P F + +V E A G + V ATDEDG + + YSL
Sbjct: 3302 SDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI 3361
Query: 2854 TSSP--YFGINQTTGAL 2868
+ +F I+ G L
Sbjct: 3362 GGNQLGHFTIHPKKGEL 3378
Score = 725 bits (1871), Expect = 0.0
Identities = 780/2866 (27%), Positives = 1244/2866 (43%), Gaps = 263/2866 (9%)
Query: 107 LDREQRDRYRFTAVTPDG--------ATVEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
LDRE RY D + ++ + + D+ND++P L+VPE
Sbjct: 881 LDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940
Query: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
GT A D D G G Y L DGA TFR++ G L++ ELD E R
Sbjct: 941 GTVLTFLDASDPDLGPAGEVRYVLM-DGAHGTFRVDLMTGA-------LILERELDFERR 992
Query: 219 SHYMLQLEAYDGGSP-PRRAQALLDVTLLDIND--HAPAFNQSRYHAVVSESLAPGSPVL 275
+ Y L L A DGG P RR ++V +LD+N+ H P F + V E+ G+ V+
Sbjct: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVI 1052
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
V A D D+G++G + Y + R G FSI+ TG++Q PLD E + L V A
Sbjct: 1053 VVAAQDDDSGLDGELQYFL--RAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV 1110
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G+ P V + V DANDN P M+ A P + E AP G V ++ DPD
Sbjct: 1111 DRGSVPLSSVTEVYIEVTDANDNPPQMS----QAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
Query: 396 GDFAHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLR 453
+ ++ G G F + V L+ A++LDRE +D + L VT D+G P L+
Sbjct: 1167 SSKGKLTFNITSGNYMGFFMIHP---VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLK 1223
Query: 454 AEAAFVLHVTDVNDNAPAFDRQLYR---PEPLPEVALPGSFVVRVTARDPDQGTNGQVTY 510
+ + V+ + DVNDN P F +L+ PE L V+ PG V R+ A D D+G NG+VTY
Sbjct: 1224 STSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVS-PGP-VYRLVASDLDEGLNGRVTY 1281
Query: 511 SLAPGAHTHWFSIDPTSGIITTAASL---DYELEPQPQLIVVATDGGLPPLASSATVSVA 567
S+ + FSID +G+++++++ +Y + L + ATD G PPL SA+V +
Sbjct: 1282 SIED-SDEEAFSIDLVTGVVSSSSTFTAGEYNI-----LTIKATDSGQPPL--SASVRLH 1333
Query: 568 LQDVNDNEPQ-----FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLG 622
++ + P F T+Y+ ++ E T P + V + + G GL +++ G
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVME-TDPVNHMVGVISVE---GRPGLFWFNISGG-- 1387
Query: 623 SSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNP 682
F I+ +G + R LD + S+++ TV DG + +++ N +
Sbjct: 1388 -DKDMDFDIEKTTGSIVIARPLDTRRR-SNYNLTVEVTDGSRTIATQVHIFMIANINHHR 1445
Query: 683 PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSP---PLFTLDEQS 739
PQF Y + + PG +LR++A D D+G L Y I P LF LD S
Sbjct: 1446 PQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSS 1503
Query: 740 GLLTVAWPLARRAN-SVVQLEIGAEDGGGLQAEPSAR----VDISIVPGTPTPPIFEQLQ 794
G+L L + S L + D Q P R V I + G PP F QL
Sbjct: 1504 GVLVTVGKLDLGSGPSQHTLTVMVRD----QEIPIKRNFVWVTIHVEDGNLHPPRFTQLH 1559
Query: 795 YVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLD 853
Y SVP+ +APGT + V+A + G A V SL G+ G F+++A+ G++ + LD
Sbjct: 1560 YEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
Query: 854 RELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPI 913
+ P G P +A V + + + ++P F E V +P + G+PI
Sbjct: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
Query: 914 YTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972
+ A+ P S VT+ L G G F+++ +G + + L +++L++
Sbjct: 1680 LLVSAMSP-----SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIR--- 1731
Query: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQ-------VQAQ 1025
GS + + VVV + AP F T+ + + ++ + A
Sbjct: 1732 -GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHAS 1790
Query: 1026 APD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAEL 1082
D + Y + A F ++P G L + + +D E+ + V L
Sbjct: 1791 DSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL 1850
Query: 1083 GQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTY 1142
A V + + + N+ PR SE +A+ PG + V A+D DS N Y
Sbjct: 1851 FAPR-PAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----Y 1905
Query: 1143 SLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202
S++ + D +A IHP TG ++ L S +L ++ DG T V +++
Sbjct: 1906 SIKTGNAD-EAVTIHPVTGSISVLNPAFLGL--SRKLTIRASDG---LYQDTALVKISLT 1959
Query: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262
+ D S F Q A V + + + L A+ N T+ Y L G++
Sbjct: 1960 QVLDKSLQFDQDVYWAA------VKENLQDRKALVILGAQG--NHLNDTLSYFLLN-GTD 2010
Query: 1263 LFSLHPHSGELLTAAPLI-RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPP 1321
+F + +G L T R ++ + L + D +P R A + V +
Sbjct: 2011 MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI---------- 2060
Query: 1322 PDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAP-EPAGV-GALTYTLVGGADPEGTF 1379
D+ + P T+ +G PG +L V+A E G GA+TY A+ F
Sbjct: 2061 EDVNDNPPKFKHLPYYTIIQ-DGTEPGDVLFQVSATDEDLGTNGAVTYEF---AEDYTYF 2116
Query: 1380 ALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARD 1439
+D G + L +P D++A + + +G G + +V V N+ P F
Sbjct: 2117 RIDPYLGDISLKKPFDYQALNKYHLKVIARDG--GTPSLQSEEEVLVTVRNKSNPLFQSP 2174
Query: 1440 PLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPR 1499
+ +PEN + +A +G + Y ++ +EP + D +TG L+
Sbjct: 2175 YYKVRVPENITLYTPILHTQARSPEG----LRLIYNIVEEEP-LMLFTTDFKTGVLTVTG 2229
Query: 1500 GLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS-PSRVRLPEDQ 1558
LD E+ + V ATD + + + V V D NDN P F+ + E
Sbjct: 2230 PLDYESKTKHVFTVRATDTALGSF----SEATVEVLVEDVNDNPPTFSQLVYTTSISEGL 2285
Query: 1559 PPGPAALHVVARDPDLGEAARVSYRLASGGDG---HFRLHSSTGALSVVRPLDREQRAEH 1615
P + ++A D D G VSY++ G F+++ STG +S V+ LD E +
Sbjct: 2286 PAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHF 2345
Query: 1616 VLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATD 1675
+ V A D G PP + ++ V+V+D+ND P F+Q +Y + E G +L ++A D
Sbjct: 2346 HVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAID 2405
Query: 1676 PDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQD---RGSP 1729
PD ++ Y G F ++ +G+++ + NL V A D R +
Sbjct: 2406 PDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATV 2465
Query: 1730 PQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYR 1788
P + T + N ++P F E+ E T + L A D D G G + Y
Sbjct: 2466 PVYINTT------NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
Query: 1789 ILDGDPSGAFVLDLASGEFGTMRPLDRE--VEPAFQLRIEARDGGQPALSATLLLTVTVL 1846
I++ S F ++ +G+ T++ LDRE E +++ ARDGG T+ + +T
Sbjct: 2520 IINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT-- 2576
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLE- 1905
D ND+ P F Y+V + +V + ++Q+ A+D D G N VTY + ++E
Sbjct: 2577 DENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEI 2636
Query: 1906 -PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSP 1964
P +G ++ +L + + F + A DG GP V + ++ V P
Sbjct: 2637 NPVTGVVKVKDSLVGLENQTLDFFIKAQDG---GPPHWNSLVPVRLQVV----------P 2683
Query: 1965 LRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP------GTT------ 2012
++ LP+ FS P + ED G+ I+ +A P GTT
Sbjct: 2684 KKVSLPK----FSEPLYTFSA--PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKD 2737
Query: 2013 ----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQ-GEA-ERGP 2066
+D TG I+V + + + ++A L ++ V +Q G+ + P
Sbjct: 2738 GVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT--DVVSLVSVNIQVGDVNDNRP 2795
Query: 2067 RFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILS---GNEKGTFSIQPSTG 2122
F +A + EN P GT ++ A+ G +G ++Y + + N F+I +G
Sbjct: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESG 2855
Query: 2123 AITVRSAEGLDFEVSPRLRLVLQAESGGAF----AFTVLTLTLQDANDNAPRFLRPHYVA 2178
IT + + LD E + A G + ++ +++ D NDNAPRF Y
Sbjct: 2856 WIT--TLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
Query: 2179 FLPE-SRP--LEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGT--ITTTA 2233
+ E S P L L ++AD +Q Q++ + P G F + I++
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNR--QVTCYITEGDPL-GQFGISQVGDEWRISSRK 2970
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLG 2292
LDRE A+ L + A+D A S T+ + V+D NDN P Q + +V ED G
Sbjct: 2971 TLDREHTAKYLLRVTASDGKFQA---SVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
Query: 2293 SEIAQVTGNDVDSGPVLWYVLSPSGP-QDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLA 2351
I +V+ D+D+ S GP F + + G ++ LD E+ D + L A
Sbjct: 3028 HFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKA 3087
Query: 2352 HDGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
DG +A++T+ VEDVNDNAP F S V + ++T + + V A D D GAN
Sbjct: 3088 TDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQ 3147
Query: 2411 ISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP-GRAARATV 2468
+ Y L A+G FS+D G + L +++ + A D G P + TV
Sbjct: 3148 VVYSLPDSAEGHFSIDATTGVIRL---EKPLQVRPQAPLELTVRASDLGTPIPLSTLGTV 3204
Query: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG 2528
V + D+ P F + + V V ED PPG+ +L L G+ Y ++SGN
Sbjct: 3205 TVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEK---TGYRVVSGNEQ 3261
Query: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV 2588
F+L+ R G L + LDFE+ +Y L++ + + S V V
Sbjct: 3262 GRFRLDART--------------GILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTV 3307
Query: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSG 2648
V + DVN++ P F + Y V E+ VG +L V A+D D + + +++ G+ G
Sbjct: 3308 MVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLG 3367
Query: 2649 LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFAL-APVTIEVQDVNDHGPAFP 2707
F + G L++A ALD E + + L ++A D + I+V DVND+ P F
Sbjct: 3368 HFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFF 3427
Query: 2708 LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGEL 2767
ST+V EN P G+ V L D D+ G + G AF + G L
Sbjct: 3428 QLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKG---NNGSAFRVTPD-GWL 3483
Query: 2768 RARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEG 2825
E ++L + A+D+G LS+ +V V VT + Y P L V E
Sbjct: 3484 VTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGED 3543
Query: 2826 ARRGHSLGHVQATDEDGGADGLVLYSLA---TSSPYFGINQTTGAL 2868
+G +G + ATD D + YSLA T +F + G +
Sbjct: 3544 EFQGGMVGKIHATDRD--PQDTLTYSLAEEETLGRHFSVGAPDGKI 3587
Score = 724 bits (1869), Expect = 0.0
Identities = 771/2866 (26%), Positives = 1219/2866 (42%), Gaps = 280/2866 (9%)
Query: 180 YALSGDGAGETFRLETRPGPDGTPVPELVVTGEL-DRENRSHYMLQLEAYDGGSPPRRAQ 238
Y L F+L R G L+ T +L D +R+HY L + + P +A
Sbjct: 395 YVLKPSSENVGFKLNARTG--------LITTTKLMDFHDRAHYQLHIR-----TSPGQAS 441
Query: 239 ALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQ 298
++ + ++D N+HAP FN+S Y + E++ PG+ VL V A+D D G NG VTY I +
Sbjct: 442 TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPK 501
Query: 299 SEGDGPFSIDAHTGLLQLERPLDFE-QRRVHELVVQARDGGA-HPELGSAFVTVHVRDAN 356
+ PFSID + G++ +P+D+E +R++ V+A D G+ + + +R+ N
Sbjct: 502 AL---PFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
Query: 357 DNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALST 416
DNQP +F + + + + P G+ + +S D D+ + +F L+
Sbjct: 559 DNQP----MFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNH 614
Query: 417 QDSVIYLVCVARRLDREERDAYNLRVTATDS---GSP---------------PLRAEAAF 458
VI L L + +Y+L++TA+D SP P+ +
Sbjct: 615 FSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTG 674
Query: 459 VL--------------------------HVTDVNDNAPAFDRQLYRPEPLPEVALPGSFV 492
VL +N P F+ + + E + +
Sbjct: 675 VLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPL 734
Query: 493 VRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATD 552
R+ A DPD G NG++ Y +A G F I+ +G++T AA LDYE L V D
Sbjct: 735 ARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
Query: 553 GGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGL 612
G P +S ++V ++D NDN P+F Y ++ E T+ GT ++T DADS G
Sbjct: 795 LGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGR 854
Query: 613 LSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD----GGGLKSM 668
+ Y+L S + F + +G++ T LDR+ P + V A D G L S+
Sbjct: 855 VRYTL-----LSPTEKFSLHPLTGELVVTGHLDRESEP-RYILKVEARDQPSKGHQLFSV 908
Query: 669 VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGN 728
+ + L D NDN PQ + PPGT + L A DPD G G + Y +L
Sbjct: 909 TDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY-VLMDG 967
Query: 729 SPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG-GLQAEPSARVDISIVPGTPT- 786
+ F +D +G L + L + L + A DGG L V++ ++
Sbjct: 968 AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENL 1027
Query: 787 -PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGGDPRGLFSLDAVSG 844
PP F + V E+ GT V +V A + L + L G FS++ +G
Sbjct: 1028 HPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG 1087
Query: 845 LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904
++QTL PLDRE + G P +V V + + D NDN P +
Sbjct: 1088 MIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQ 1147
Query: 905 PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963
+ GT + L A DPDS ++TF + +G G F + P TG + + L
Sbjct: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDE 1207
Query: 964 HELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLP---SGTTAGTQVL 1020
H LE+ D G P S R+ V + DV P F+ + V LP S + G
Sbjct: 1208 HILEVTVLDNGEPSLKSTSRVVVGILDVNDN--PPIFSHKLFNVRLPERLSPVSPGPVYR 1265
Query: 1021 QVQAQAPDG--GPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGS 1078
V + +G G +TY + + F ++ +G V ++ A E IL + A
Sbjct: 1266 LVASDLDEGLNGRVTYSI-EDSDEEAFSIDLVTG--VVSSSSTFTAGEYNILTIKA---- 1318
Query: 1079 KAELGQQTGTATVRVS---ILNQNEHSPRLSEDPTF--LAVAENQPPGTSVGRVFATDRD 1133
+ GQ +A+VR+ I S L+ D T+ V E P VG +
Sbjct: 1319 -TDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV---- 1373
Query: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
G G +++ +D F I TG + + LD ++S+Y L V+V DG R+
Sbjct: 1374 EGRPGLFWFNISGGDKDMD-FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---RTI 1429
Query: 1194 TGTVHV-AVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI 1252
VH+ + ++N + P FL+ ++VP PG + +QA D D+G+ ++
Sbjct: 1430 ATQVHIFMIANINHHRPQFLETR------YEVRVPQDTVPGVELLRVQAIDQDKGK--SL 1481
Query: 1253 LYTLTG---PGS-ELFSLHPHSGELLTAAPLIRAERP-HYVLTLSAHDQGSPPRSASLQL 1307
+YT+ G PGS LF L P SG L+T L P + LT+ DQ P + + +
Sbjct: 1482 IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWV 1541
Query: 1308 LVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-PAGVGA-L 1365
+ V PP + A VP + + PG+ L V A + GV A +
Sbjct: 1542 TIHVEDGNL---HPPRFTQLHYEASVP--------DTIAPGTELLQVRAMDADRGVNAEV 1590
Query: 1366 TYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGAR-LLRVQV 1424
Y+L+ G + EG F ++A G + LA+ LD +A LTV+AE G L V +
Sbjct: 1591 HYSLLKG-NSEGFFNINALLGIITLAQKLD-QANHAPHTLTVKAEDQGSPQWHDLATVII 1648
Query: 1425 QVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP 1484
V + AP F++ + +PE+ G+ + A S+V Y LR+
Sbjct: 1649 HVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP------SEVTYE-LREGNKDG 1701
Query: 1485 ALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP 1544
+++ +G +S + LD E + L + ++ V V + DENDNAP
Sbjct: 1702 VFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG-----AFTDVMVVVDIIDENDNAP 1756
Query: 1545 VFASPSRVRLPEDQPP----------GPAALHVVARDPDLGEAARVSYR-LASGGDGHFR 1593
+F + V + P P +H A D D + + Y+ L F+
Sbjct: 1757 MFLKSTFVGQISEAAPLYSMIMDKNNNPFVIH--ASDSDKEANSLLVYKILEPEALKFFK 1814
Query: 1594 LHSSTGALSVVRPLDREQRAEHVLTVVASDHGSP----PRSATQVLTVSVADVNDEAPTF 1649
+ S G L++V +D E V D GSP PR A + + V DVND P F
Sbjct: 1815 IDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVI--IHVRDVNDSPPRF 1872
Query: 1650 QQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLR-- 1707
+Q Y V + PG LL +RA+D D N + G + E+ ++ P TG ++ L
Sbjct: 1873 SEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGN-ADEAVTIHPVTGSISVLNPA 1931
Query: 1708 --ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEG-Q 1764
L R+ LT+ A D V++++ D + F V E Q
Sbjct: 1932 FLGLSRK------LTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQ 1982
Query: 1765 DPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR-PLDREVEPAFQL 1823
D + L +L A + N L Y +L+G + F + ++G T DRE + +L
Sbjct: 1983 DRKALVILGAQGNHL--NDTLSYFLLNG--TDMFHMVQSAGVLQTRGVAFDREQQDTHEL 2038
Query: 1824 RIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPD 1883
+E RD P A L+ V++ D ND+ P F Y + + G +L Q+ A D D
Sbjct: 2039 AVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDED 2098
Query: 1884 AGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT 1943
G NG VTY A F ++P G++ D + Y V A DG L +
Sbjct: 2099 LGTNGAVTYEF-AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS-LQSE 2156
Query: 1944 VSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003
V +TVR N P F + ++R+P TL L + R I +
Sbjct: 2157 EEVLVTVR--NKSNPLFQSPYYKVRVP------ENITLYTPILHTQARSPEGLRLIYNIV 2208
Query: 2004 AGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIV-ATDLGRPARSATGVIIVGLQGEA 2062
P T D TG + V P+ + + +F V ATD + S V ++ ++
Sbjct: 2209 EEEPLMLFTTDFKTGVLTVT-GPLDYESKTKHVFTVRATDTALGSFSEATVEVL-VEDVN 2266
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGT--FSIQP 2119
+ P F + +I E P TP++ A G N ++Y I+ + F I
Sbjct: 2267 DNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQING 2326
Query: 2120 STGAITVRSAEGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY 2176
STG ++ + + LD+E + ++A G T++ + + D NDN P F +P Y
Sbjct: 2327 STGEMS--TVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQY 2384
Query: 2177 VAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILD 2236
A + E +L+V+A D D ++ Y + + R F ++ ++G I+ +
Sbjct: 2385 EANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFF-INSSSGIISMFNLCK 2443
Query: 2237 REIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNR--PTIPQP-WELRVSEDALLGS 2293
+ + + L + A+D V AT+ V + TN N+ P Q +E ++E+A++G+
Sbjct: 2444 KHLDSSYNLRVGASDG-----VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGT 2498
Query: 2294 EIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDR--YQLQL 2349
++ + D DSGP + Y + + FS+ G+++ LD E +++
Sbjct: 2499 KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKV 2557
Query: 2350 LAHDGPHEGR---ANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
+A DG GR + +++ D NDN P F S Y V + + S ++ V A D D G
Sbjct: 2558 MARDG--GGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEG 2615
Query: 2407 ANGHISYHLASP---ADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRA 2463
N ++Y + D ++P G + V L + +D ++A+D G P
Sbjct: 2616 QNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ---TLDFFIKAQDGGPPHWN 2672
Query: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
+ V +Q+ + P F+ Y + EDLP GS + ++A A ++ V +
Sbjct: 2673 SLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTP 2732
Query: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS 2583
N VF L+P G + + +P+D ES Y + V A
Sbjct: 2733 ESNKDGVFSLDP--------------DTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVV 2778
Query: 2584 SVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS 2643
S+V V + V DVNDN PVF Y+ + E+ PVG ++ V A D D G G V + +S+
Sbjct: 2779 SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSA 2838
Query: 2644 GDPSG----LFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFAL---APVTIEV 2696
DP LF +D SG + LDCET + V A D G L A V + +
Sbjct: 2839 -DPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYD-HGQTIQLSSQALVQVSI 2896
Query: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
D ND+ P F SV EN PG LV TL +D D R + G P G+
Sbjct: 2897 TDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEG-DPLGQF 2955
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAP 2816
+ + +R D EHT + L V A+D G ASVTV + V ++ P
Sbjct: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVTVEIFVLDVNDNSPQCSQL 3014
Query: 2817 AFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRA 2876
+ +V E GH + V ATD D + + YSL GA ++D
Sbjct: 3015 LYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL----------HGPGAHEFKLD--- 3061
Query: 2877 PGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDI 2922
P +G T+ T + R+ ++A+ G RS +T+ +
Sbjct: 3062 PHTGELTT----LTALDRERKDVFNLVAKATDGGGRSCQADITLHV 3103
Score = 710 bits (1833), Expect = 0.0
Identities = 744/2782 (26%), Positives = 1172/2782 (42%), Gaps = 253/2782 (9%)
Query: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
T L+RE R Y L ++A + + A + V +LD ND P F+ Y +SE +
Sbjct: 104 TALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMP 162
Query: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
SP+ +V A+DAD G N Y N R F+I +G++ + L+ R HE
Sbjct: 163 LKSPICKVTATDADLGQNAEFYYAFNTRSEM----FAIHPTSGVVTVAGKLNVTWRGKHE 218
Query: 330 LVVQARDGGAHPELGSAF-----VTVHVRDANDNQPSMTVIFL----SADGSPQVS---E 377
L V A D G+ F + VHV A P++ + + S DG+ + +
Sbjct: 219 LQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVD 278
Query: 378 AAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDA 437
A G V + V D G S +A S + S LV V E
Sbjct: 279 ANSSGAEVESVEVVGGDPGKHFKAIKS-------YARSNEFS---LVSVKDINWMEYLHG 328
Query: 438 YNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVV--RV 495
+NL + A SGS P H+ ++ F++ +YR + L E + PGS VV RV
Sbjct: 329 FNLSLQAR-SGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQ-LSEFSPPGSRVVMVRV 386
Query: 496 TARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGL 555
T P+ + Y L P + F ++ +G+ITT +D+ QL + + G
Sbjct: 387 TPAFPN------LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPG-- 438
Query: 556 PPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSY 615
+S V + + D N++ P F R+ Y+ +L E PGT L VTATD D G G ++Y
Sbjct: 439 ---QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTY 495
Query: 616 SLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD-GGGLKSMVYVKVF 674
S + + PF ID + G + T++ +D + + F V A D G + V +F
Sbjct: 496 S----IAGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIF 551
Query: 675 LS--DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPL 732
L + NDN P F SI P G +++ + A D D+ + L Y I++GN
Sbjct: 552 LQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEY 609
Query: 733 FTLDEQSGLLTVAWP---LARRANSVVQLEIGAEDGG----------------------- 766
F L+ SG++++ P L + L+I A DG
Sbjct: 610 FDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVT 669
Query: 767 ------------------GLQAEPSARVDISIVP----GTPTPPIFEQLQYVFSVPEDVA 804
GLQ + S+ + + + TP + V E V
Sbjct: 670 CDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVP 729
Query: 805 PGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLEL 863
T + + A +P G + ++ G+ G F ++ +GLL PLD E +
Sbjct: 730 INTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILN 789
Query: 864 EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDS 923
G P + + V + D NDN+P FP + + +T GT I L D DS
Sbjct: 790 VTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADS 849
Query: 924 GVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRT--SH 981
N RV +TLL+ F++ P TG + + L P + L++EARD S S
Sbjct: 850 EDNGRVRYTLLS-PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSV 908
Query: 982 FRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPI--TYHLAAE 1039
L + ++DV +P+ + R+ +P GT + + A PD GP ++ +
Sbjct: 909 TDLIITLEDVNDN--SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD 966
Query: 1040 GASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQN 1099
GA F ++ +G L + LD E + Y L + A G + + V V +N+N
Sbjct: 967 GAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNEN 1026
Query: 1100 EHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQ 1159
H P + V EN P GT V V A D DSG +G L Y L + AF I+
Sbjct: 1027 LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFL-RAGTGLAAFSINQD 1085
Query: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1219
TG + TL LDRE S Y L V D GS P S+ V++ V D NDN P QA
Sbjct: 1086 TGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV---- 1141
Query: 1220 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAP 1278
+ + P GT V L A DPD G + + +T G F +HP +G L TA
Sbjct: 1142 --FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ 1199
Query: 1279 LIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLT 1338
L R + ++L ++ D G P ++ +++V +L + + PP + + +P L+
Sbjct: 1200 LDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILD---VNDNPPIFSHKLFNVRLPERLS 1256
Query: 1339 VTAAEGLRPGSLLGSVAAPEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARPLDFE 1397
+ PG + VA+ G+ G +TY++ E F++D +G ++ F
Sbjct: 1257 PVS-----PGPVYRLVASDLDEGLNGRVTYSIED--SDEEAFSIDLVTG--VVSSSSTFT 1307
Query: 1398 AGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYT 1457
AG + LT++A +G L V++ E P + PLA Y+
Sbjct: 1308 AG-EYNILTIKAT---DSGQPPLSASVRLHIEWIPWPRPSSIPLAF--------DETYYS 1355
Query: 1458 FRASDADGPGPNSDVRYRLLRQEPPV-----------PALRLDARTGALSAPRGLDRETT 1506
F + D N V + P + ++ TG++ R LD
Sbjct: 1356 FTVMETD--PVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRR 1413
Query: 1507 PALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAAL 1565
L VE TD SR A +V + + N + P F VR+P+D PG L
Sbjct: 1414 SNYNLTVEVTD----GSRTIATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELL 1468
Query: 1566 HVVARDPDLGEAARVSYRLAS--GGDGHFRLHSSTGALSVVRPLD-REQRAEHVLTVVAS 1622
V A D D G++ + + G F+L S+G L V LD ++H LTV+
Sbjct: 1469 RVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVR 1528
Query: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
D P + +T+ V D N P F Q Y + + PGT LL +RA D D G N
Sbjct: 1529 DQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNA 1588
Query: 1683 QVTYG---GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV 1739
+V Y G S F+++ G++T + LD+ LTV A+D+GSP TV +
Sbjct: 1589 EVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVII 1648
Query: 1740 AVEDENDHAPTFGSAHLSLEVPEG-QDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAF 1798
V + AP F + +E+PE + ++ A P ++ Y + +G+ G F
Sbjct: 1649 HVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVF 1703
Query: 1799 VLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVP 1858
++ SG T + LD E ++QL+I R +++ V ++D ND+AP F
Sbjct: 1704 SMNSYSGLISTQKKLDHEKISSYQLKI--RGSNMAGAFTDVMVVVDIIDENDNAPMFLKS 1761
Query: 1859 AYSVEVPEDVPAGTLLLQ-------LQAHDPDAGANGHVTY-YLGAGTAGAFLLEPSSGE 1910
+ ++ E P ++++ + A D D AN + Y L F ++PS G
Sbjct: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGT 1821
Query: 1911 LRTAAALDREQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
L + +D E PS+ F V D G+ V I VRDVND P F + +
Sbjct: 1822 LTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
Query: 1970 PRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVAL 2029
P P + L +RA D D+ N SI G T+ TG I V +P L
Sbjct: 1882 VGP----IHPGMELLMVRASDEDSEVNYSI---KTGNADEAVTIHPVTGSISVL-NPAFL 1933
Query: 2030 GPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVS 2089
G R L I A+D T ++ + L ++ +F + A ++EN +V
Sbjct: 1934 G-LSRKLTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVI 1989
Query: 2090 PRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG 2149
A N ++Y +L+G + F + S G + R D E L ++
Sbjct: 1990 LGA-QGNHLNDTLSYFLLNGTD--MFHMVQSAGVLQTRGV-AFDREQQDTHELAVEVRDN 2045
Query: 2150 GA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQI 2206
A ++ ++++D NDN P+F Y + + L QV A D D G+ G +
Sbjct: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105
Query: 2207 SYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVM 2266
+Y A F +DP G I+ D + + L ++A D G+P+L + V
Sbjct: 2106 TYEFAEDYT---YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVT 2162
Query: 2267 VIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVG 2325
V N + P P +++RV E+ L + I + G L Y + P F+
Sbjct: 2163 V--RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GLRLIYNIVEEEPLMLFTTD 2219
Query: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLAHDGP--HEGRANLTVLVEDVNDNAPAFSQSLYQV 2383
G +++TGPLD+E ++ + A D A + VLVEDVNDN P FSQ +Y
Sbjct: 2220 FKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTT 2279
Query: 2384 MLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG----FSVDPNNGTLFTIVGTVA 2439
+ E P + ++ + A+D+DSG N +SY + F ++ + G + T+
Sbjct: 2280 SISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTV---QE 2336
Query: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
L ++ V + A D G P V V + D ND+ P F Y V+E G
Sbjct: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
Query: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559
+L ++A D D SR + ++Y I+SGN R F + + G + +
Sbjct: 2397 LVLKVQAIDPD-SRDTSRLEYLILSGNQDRHFFIN--------------SSSGIISMFNL 2441
Query: 2560 LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGA 2619
+ YNL V A+D + VPV + + N P F + Y + E+ VG
Sbjct: 2442 CKKHLDSSYNLRVGASD---GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGT 2498
Query: 2620 ELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQA 2679
+++ + A D D GP+G + +T+ + S F ++ +G + LD E + ++
Sbjct: 2499 KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKV 2557
Query: 2680 -ADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF 2738
A G A V I + D ND+ P F + + S+ N + V + A D D G
Sbjct: 2558 MARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQN 2617
Query: 2739 GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSAS 2796
+ YS+ P ++ +N TG ++ + ++ + A D G + ++
Sbjct: 2618 ADVTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSL 2674
Query: 2797 VTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL---- 2852
V V + V + P F P + F PE G +G V+A A V+YSL
Sbjct: 2675 VPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV----AAQDPVIYSLVRGT 2730
Query: 2853 ---ATSSPYFGINQTTGALYLR 2871
+ F ++ TG + +R
Sbjct: 2731 TPESNKDGVFSLDPDTGVIKVR 2752
Score = 649 bits (1675), Expect = 0.0
Identities = 647/2266 (28%), Positives = 992/2266 (43%), Gaps = 227/2266 (10%)
Query: 76 LMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQR-DRYRFTAVTPDGAT------VE 128
L+Y I + G + +D SGV+ T LD ++ T + D V
Sbjct: 1481 LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVW 1540
Query: 129 VTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAG 188
VT+ V D N H P F Q VP+ A GT A DAD G Y+L +
Sbjct: 1541 VTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSE 1600
Query: 189 ETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDI 248
F + G + + +LD+ N + + L ++A D GSP A + + +
Sbjct: 1601 GFFNINALLGI-------ITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPS 1653
Query: 249 NDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSID 308
+ AP F++S Y + ES+ GSP+L V A VTYE+ R+ DG FS++
Sbjct: 1654 DRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-----VTYEL--REGNKDGVFSMN 1706
Query: 309 AHTGLLQLERPLDFEQRRVHELVVQARD-GGAHPELGSAFVTVHVRDANDNQPSMTVIFL 367
+++GL+ ++ LD E+ ++L ++ + GA ++ V V + D NDN P +FL
Sbjct: 1707 SYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---MVVVDIIDENDNAP----MFL 1759
Query: 368 SADGSPQVSEAAPPGQLVAR-------ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV 420
+ Q+SEAAP ++ I SD D + + + E S+
Sbjct: 1760 KSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSM 1819
Query: 421 IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE--AAFVLHVTDVNDNAPAFDRQLYR 478
L V+ +D E ++ V D GSP L A A ++HV DVND+ P F Q+Y
Sbjct: 1820 GTLTIVSE-MDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY- 1877
Query: 479 PEPLPEVAL-----PGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTA 533
EVA+ PG ++ V A D D +V YS+ G +I P +G I+
Sbjct: 1878 -----EVAIVGPIHPGMELLMVRASDEDS----EVNYSIKTGNADEAVTIHPVTGSISVL 1928
Query: 534 ASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQP 593
L + L + A+DG +A V ++L V D QF + Y A++ E Q
Sbjct: 1929 NPAFLGLSRK--LTIRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQD 1983
Query: 594 GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTR--TLDRDQGPS 651
+ + A LSY L +G+ F + S V TR DR+Q
Sbjct: 1984 RKALVILGAQGNHLND--TLSYFL-----LNGTDMFHM-VQSAGVLQTRGVAFDREQ-QD 2034
Query: 652 SFDFTVTAVDGGGLKSMVY--VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRA 709
+ + V D + + V+V + D NDNPP+F Y I + PG + ++ A
Sbjct: 2035 THELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSA 2094
Query: 710 HDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG--G 767
D D G++G ++Y + F +D G +++ P +A + L++ A DGG
Sbjct: 2095 TDEDLGTNGAVTYEFAEDYT--YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
Query: 768 LQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLS 827
LQ+E V + + P+F+ Y VPE++ T + QA +P G + +
Sbjct: 2153 LQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEG--LRLIYN 2206
Query: 828 LSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDV 887
+ +P LF+ D +G+L PLD E + VRA +F+ A V VL++DV
Sbjct: 2207 IVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHV-FTVRATDTALGSFSEATVEVLVEDV 2265
Query: 888 NDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVD 944
NDN P F T + TP+ L A D DSG N V++ ++ G F ++
Sbjct: 2266 NDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQIN 2325
Query: 945 PTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPT 1004
+TG + ++ L +++ A D G PP T + V V D+ P F P
Sbjct: 2326 GSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDN--PPEFRQPQ 2383
Query: 1005 YRVDLPSGTTAGTQVLQVQAQAPDG---GPITYHLAAEGASSPFGLEPQSGWLWVRAALD 1061
Y ++ T G VL+VQA PD + Y + + F + SG + +
Sbjct: 2384 YEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK 2443
Query: 1062 REAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPG 1121
+ Y L+V A G T V ++ N N++SP + +AEN G
Sbjct: 2444 KHLDSSYNLRVGASDGVFR------ATVPVYINTTNANKYSPEFQQHLYEAELAENAMVG 2497
Query: 1122 TSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLV 1181
T V + A D+DSGP G + Y++ K F I+P G++ TLQ LDRE + + +
Sbjct: 2498 TKVIDLLAIDKDSGPYGTIDYTIINKLASEK-FSINPN-GQIATLQKLDRENSTERVIAI 2555
Query: 1182 QV--QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
+V +DGG R TV + + D NDN P F + + + V + V +
Sbjct: 2556 KVMARDGGG--RVAFCTVKIILTDENDNPPQFKASE------YTVSIQSNVSKDSPVIQV 2607
Query: 1240 QAKDPDEGENGTILYTLTGPG--SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQG 1297
A D DEG+N + Y++ ++ ++P +G + L+ E + A D G
Sbjct: 2608 LAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG 2667
Query: 1298 SPPRSASLQLLVQVLPSA----RLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG- 1352
P ++ + + +QV+P + +EP + T +A E L GS +G
Sbjct: 2668 PPHWNSLVPVRLQVVPKKVSLPKFSEP---------------LYTFSAPEDLPEGSEIGI 2712
Query: 1353 --SVAAPEPAGVGALTYTLVGGADPE----GTFALDAASGRLYLARPLDFEAGPPWRALT 1406
+VAA +P + Y+LV G PE G F+LD +G + + +P+D E+ ++
Sbjct: 2713 VKAVAAQDP-----VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDV 2767
Query: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP 1466
+ L+ V +QV D N++ P F DP L EN G ++ A D D
Sbjct: 2768 MAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKD-T 2826
Query: 1467 GPNSDVRYRLLRQEPPV--PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASR 1524
G + V YRL +D+ +G ++ + LD ET V A D
Sbjct: 2827 GRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL 2886
Query: 1525 RRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR 1583
A V +V +TDENDNAP FAS R + E+ PG + D D+ E R
Sbjct: 2887 SSQALV--QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTC 2944
Query: 1584 LASGGD--GHFRLHSSTG---ALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
+ GD G F + S G +S + LDRE A+++L V ASD G S T + +
Sbjct: 2945 YITEGDPLGQFGI-SQVGDEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVT--VEIF 3000
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG--GVSSESFSL 1696
V DVND +P Q Y+ + E+ PG +L + ATD D N Q+TY G + F L
Sbjct: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
Query: 1697 DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL 1756
DP TG LTTL ALDRE ++ NL A D G +T+ V ED ND+AP F +H
Sbjct: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHV--EDVNDNAPRFFPSHC 3118
Query: 1757 SLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
++ V + +T + ++ A DPD GAN Q+ Y + D G F +D +G +PL
Sbjct: 3119 AVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDS-AEGHFSIDATTGVIRLEKPLQV 3177
Query: 1816 EVEPAFQLRIEARDGGQPALSATL-LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLL 1874
+ +L + A D G P +TL +TV+V+ D+ P F +SV+VPED P GT +
Sbjct: 3178 RPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
Query: 1875 LQLQAHD-PDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVD 1933
LQL P A G+ + G F L+ +G L A+LD E P Y S+
Sbjct: 3238 LQLATLTRPGAEKTGYRV--VSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-S 3294
Query: 1934 GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDA 1993
++ LS +V + + DVN+H P FP P R+ + T+ A D D
Sbjct: 3295 RKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDV----ILTVSATDEDG 3350
Query: 1994 GANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG 2052
N+ I Y L G G T+ GE++VA++ L + ATD G+P
Sbjct: 3351 PLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDT 3410
Query: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVS-----PRAVHAGGTNGPITYSIL 2107
I + + + PRF + + T++EN+P G+ ++ P + G P ++ I
Sbjct: 3411 DIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGP---PYSFRIT 3467
Query: 2108 SGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDN 2167
GN F + P +T AEGL +L +QA G + LT +
Sbjct: 3468 KGNNGSAFRVTPDGWLVT---AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQ 3524
Query: 2168 APRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQI-----------SYSLAASQP- 2215
+ HY P + PLE + V D+ G G+I +YSLA +
Sbjct: 3525 S------HYA---PSALPLE-IFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETL 3574
Query: 2216 ---------------ARGL------FHVDPTTGTITTTAILDREIW 2240
A+GL F+V + GT TTTA + +W
Sbjct: 3575 GRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTTAGVHVYVW 3620
Score = 565 bits (1455), Expect = e-160
Identities = 686/2589 (26%), Positives = 1097/2589 (42%), Gaps = 254/2589 (9%)
Query: 396 GDFAHVNVSLEGGEGHFA---LSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452
GD A+V + E G+F + T+ S L L+RE RD+Y L + AT+ + L
Sbjct: 76 GDVANVFKTEEYVVGNFCFLRIRTKSSNTAL------LNREVRDSYTLIIQATEK-TLEL 128
Query: 453 RAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSL 512
A V+H+ D ND P F YR ++ L S + +VTA D D G N + Y+
Sbjct: 129 EALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLK-SPICKVTATDADLGQNAEFYYAF 187
Query: 513 APGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVN 572
+ F+I PTSG++T A L+ + +L V+A D + S+A V+
Sbjct: 188 --NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVH 245
Query: 573 DNEPQFQRTFYNASL---PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPF 629
EP ++ AS+ P + GT + V DA+S + S + G
Sbjct: 246 V-EPALRKPPAIASVVVTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAI 303
Query: 630 RIDAHSGD--VCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVF-LSDENDNPPQFY 686
+ A S + + + + ++ + F+ ++ A G G ++ F L + +F
Sbjct: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFE 363
Query: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAW 746
Y +S SPPG+ V+ +R + L Y + + F L+ ++GL+T
Sbjct: 364 KAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLNARTGLITTTK 419
Query: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
+ + QL I G + S V I IV P+F + Y ++ E++ PG
Sbjct: 420 LMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPG 474
Query: 807 TSVGIVQAHNPP-GRLAPVTLSLSGGDPRGL-FSLDAVSGLLQTLRPLDRELLGPVLELE 864
TSV V A + G VT S++G P+ L FS+D G++ T +P+D EL+ +
Sbjct: 475 TSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDYELMKRIYTFR 532
Query: 865 VRAGSGVPPAFAVARVRVLLD--DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD 922
VRA P V + L ++NDN P F T + + G I T+ A+D D
Sbjct: 533 VRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD 592
Query: 923 SGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRP---LGPSGGPAHELELEARDG---GS 975
N + + +++G F ++ +G + L RP L ++ L++ A DG S
Sbjct: 593 ELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYAS 650
Query: 976 PP-------RTSHFRLRVVVQDVGTR-----------GLAPRFNS-------PTYR---- 1006
P + HF + V G GL + +S TY+
Sbjct: 651 PTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHY 710
Query: 1007 -----------VDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSG 1052
+D+ T + ++ A PD G + Y +A F +E ++G
Sbjct: 711 TPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETG 770
Query: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELG--QQTGTATVRVSILNQNEHSPRLSEDPT 1110
L V A LD EA YIL V +LG Q++ + V++ + N+++PR
Sbjct: 771 LLTVAAPLDYEATNFYILNVTVY-----DLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825
Query: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170
L ++E+ GT++ + D DS NGR+ Y+L +E F +HP TGE+ LD
Sbjct: 826 QLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLD 882
Query: 1171 REQQSSYQLLVQVQDGGSPPR---STTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVP 1227
RE + Y L V+ +D S S T + + + D+NDNSP + ++VP
Sbjct: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLI-ITLEDVNDNSPQCITEHNR------LKVP 935
Query: 1228 DRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHY 1287
+ +PPGT++T L A DPD G G + Y L F + +G L+ L R Y
Sbjct: 936 EDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGY 995
Query: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
L+L A D G P +L + ++ PP A V E
Sbjct: 996 NLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS--------FVHQGQVQENSPS 1047
Query: 1348 GSLLGSVAA-PEPAGV-GALTYTLVGGADPEGTFALDAASGRLYLARPLDFE-AGPPWRA 1404
G+ + VAA + +G+ G L Y L G F+++ +G + PLD E A W
Sbjct: 1048 GTQVIVVAAQDDDSGLDGELQYFLRAGTG-LAAFSINQDTGMIQTLAPLDREFASYYW-- 1104
Query: 1405 LTVRAEGPGGAG-ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDA 1463
LTV A G + + V ++V D N++ P ++ ++ E+ G ++ A D
Sbjct: 1105 LTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWD- 1163
Query: 1464 DGPGPNSDVRYRL---LRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPA 1520
P+S + +L + + + TG LS + LDRE +L V D
Sbjct: 1164 ----PDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDN-G 1218
Query: 1521 NASRRRAARVSARVFVTDENDNAPVFASP-SRVRLPE---DQPPGPAALHVVARDPDLGE 1576
S + +RV V + D NDN P+F+ VRLPE PGP +VA D D G
Sbjct: 1219 EPSLKSTSRVV--VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGL 1275
Query: 1577 AARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLT 1636
RV+Y + + F + TG +S + ++LT+ A+D G PP SA+ L
Sbjct: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGE--YNILTIKATDSGQPPLSASVRLH 1333
Query: 1637 VSVAD---VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES 1693
+ + F + YS + E +P ++ + + + G GG
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGLFWFNISGGDKDMD 1392
Query: 1694 FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1753
F ++ TG + R LD + NLTV D GS T V + + + N H P F
Sbjct: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHI-FMIANINHHRPQFLE 1450
Query: 1754 AHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDG-DPSGA--FVLDLASGEFGT 1809
+ VP+ P L ++A D D G + L Y I DP A F LD +SG T
Sbjct: 1451 TRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVT 1508
Query: 1810 MRPLDREVEPA-FQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDV 1868
+ LD P+ L + RD P + +T+ V D N H P F Y VP+ +
Sbjct: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
Query: 1869 PAGTLLLQLQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELRTAAALDREQCPSYTF 1927
GT LLQ++A D D G N V Y L G + G F + G + A LD+ +T
Sbjct: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTL 1628
Query: 1928 SVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR 1987
+V A D + +V I V + AP F S + +P P +P L ++ +
Sbjct: 1629 TVKAED-QGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIP-VGSPILLVSAM- 1685
Query: 1988 AEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVAR-------SPVALGPRDRVLFIV 2039
+ + + Y L G +++SY+G I + S L R +
Sbjct: 1686 -------SPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGA 1738
Query: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV----SPRAVHA 2095
TD+ +++V + E + P F +++ I E AP + I+ +P +HA
Sbjct: 1739 FTDV---------MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHA 1789
Query: 2096 GGT----NGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA 2151
+ N + Y IL F I PS G +T+ S +D+E P + + G+
Sbjct: 1790 SDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE--MDYESMPSFQFCVYVHDQGS 1847
Query: 2152 FAF-----TVLTLTLQDANDNAPRFLRPHY-VAFLPESRPLEGPLLQVEADDLDQGSGGQ 2205
+ + ++D ND+ PRF Y VA + P LL V A D D +
Sbjct: 1848 PVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHP-GMELLMVRASDED----SE 1902
Query: 2206 ISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALV-GSATLT 2264
++YS+ A + P TG+I ++L+ +R + T R S L +A +
Sbjct: 1903 VNYSIKTGN-ADEAVTIHPVTGSI---SVLNPAFLGLSRKL---TIRASDGLYQDTALVK 1955
Query: 2265 VMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVD--SGPVLWYVLSPSGPQDPF 2322
+ + D Q ++ L + + G + + + +++L+ + D F
Sbjct: 1956 ISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGT---DMF 2012
Query: 2323 SVGRYGGRVSLTG-PLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQ 2378
+ + G + G D EQ D ++L + D R + V +EDVNDN P F
Sbjct: 2013 HMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKH 2072
Query: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTV 2438
Y ++ + T PG + VSATD D G NG ++Y A F +DP G +
Sbjct: 2073 LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISL---KK 2129
Query: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
+ + + ARD G P + V V ++++++ P F +Y+V V E++
Sbjct: 2130 PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSN--PLFQSPYYKVRVPENITLY 2187
Query: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLE 2558
+ +L +A +G R + Y+I+ +F + + G L +
Sbjct: 2188 TPILHTQARSPEGLR----LIYNIVEEEPLMLFTTDFK--------------TGVLTVTG 2229
Query: 2559 PLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVG 2618
PLD+ES T++ TV A D S V V V DVNDNPP F++ Y ++ E P
Sbjct: 2230 PLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288
Query: 2619 AELLHVEASDADPGPHGLVRFTV--SSGDPSGLFELDESSGTLRLAHALDCETQARHQLV 2676
++ + ASD D G + V + + D S F+++ S+G + LD E Q +
Sbjct: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348
Query: 2677 VQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
V+A D V + V D+ND+ P F +V+E G LV + AID D+
Sbjct: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408
Query: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSA 2795
RL Y +L G + R F +NSS+G + S+ L VGA+D G A
Sbjct: 2409 RDTSRLEYLILS---GNQDRH-FFINSSSGIISMFNLCKKHLDSSYNLRVGASD-GVFRA 2463
Query: 2796 SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAT- 2854
+V V + T ++Y P F + ++ E A G + + A D+D G G + Y++
Sbjct: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINK 2523
Query: 2855 -SSPYFGIN 2862
+S F IN
Sbjct: 2524 LASEKFSIN 2532
Score = 298 bits (764), Expect = 5e-80
Identities = 323/1179 (27%), Positives = 497/1179 (42%), Gaps = 148/1179 (12%)
Query: 1785 LQYRILDGDPSGAFVLD-LASGEFGTMRP---------LDREVEPAFQLRIEARDGGQPA 1834
++YRI+ GD + F + G F +R L+REV ++ L I+A +
Sbjct: 69 VRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE- 127
Query: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
L A + V +LD ND P F P+Y V + ED+P + + ++ A D D G N YY
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEF-YYA 186
Query: 1895 GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVD-------GAAAGPLSTTVSVT 1947
+ F + P+SG + A L+ + V AVD G G L+ V
Sbjct: 187 FNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVV-- 244
Query: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTP 2007
H P + P S AT+ + +GA + + G P
Sbjct: 245 --------HVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDP 296
Query: 2008 PPG-TTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVG------LQG 2060
+ SY S V++ + + ++ +L ARS +G L
Sbjct: 297 GKHFKAIKSYARSNEF--SLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPP 354
Query: 2061 EAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPS 2120
+F +A + E +PPG+ +V R A + Y + +E F +
Sbjct: 355 SKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN---LQYVLKPSSENVGFKLNAR 411
Query: 2121 TGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFL 2180
TG IT +DF +L ++ G A TV+ + + D N++AP F R Y L
Sbjct: 412 TGLITTTKL--MDFHDRAHYQLHIRTSPGQAS--TVVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 2181 PESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIW 2240
E+ P +L V A D D G G ++YS+A P F +DP G I+T+ +D E+
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLGIISTSKPMDYELM 525
Query: 2241 AET-RLVLMATDRGSP-ALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQ 2297
+ A+D GSP ++ + + + NDN+P + + +D +G I
Sbjct: 526 KRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Query: 2298 VTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGP---LDFEQCDRYQLQLLAHDG 2354
++ DVD L Y + + F + + G +SL P L Q Y L++ A DG
Sbjct: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
Query: 2355 PHEG---RANLTVLVE-------------------------------------------- 2367
+ N+TV+ +
Sbjct: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
Query: 2368 DVNDNAPAFSQSLYQ-VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSV 2424
+N P F Q + +LE P + + ++ATD D+G NG + Y +A + F +
Sbjct: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
Query: 2425 DPNNGTLFTIVGTVA--LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSF 2482
+ G L TVA L ++ + + + D G P +++ + V ++D ND+AP F
Sbjct: 766 ELETGLL-----TVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRF 820
Query: 2483 TLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
Y++ ++ED G+T+ L DAD S + V Y+++S F L P E
Sbjct: 821 PPGGYQLTISEDTEVGTTIAELTTKDAD-SEDNGRVRYTLLSPT--EKFSLHPLTGE--- 874
Query: 2543 SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS----SVVPVTVTVLDVNDN 2598
LV+ LD ES +Y L V A D QP + SV + +T+ DVNDN
Sbjct: 875 -----------LVVTGHLDRESEPRYILKVEARD--QPSKGHQLFSVTDLIITLEDVNDN 921
Query: 2599 PPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT 2658
P R+ VPED P G L ++ASD D GP G VR+ + G G F +D +G
Sbjct: 922 SPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGA 980
Query: 2659 LRLAHALDCETQARHQLVVQAADPAG--AHFALAPVTIEVQDVND--HGPAFPLNLLSTS 2714
L L LD E +A + L + A+D A L V + V DVN+ H P F +
Sbjct: 981 LILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQ 1040
Query: 2715 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFD 2774
V EN P GT V + A D D+G G L+Y L AG G AF++N TG ++ P D
Sbjct: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQY-FLRAG---TGLAAFSINQDTGMIQTLAPLD 1096
Query: 2775 YEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSL 2832
E + L V A D G+ LS+ V + VT ++ P F+ + E A G S+
Sbjct: 1097 REFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV 1156
Query: 2833 GHVQATDEDGGADGLVLYSLATSSPYFG---INQTTGAL 2868
+ A D D + G + +++ TS Y G I+ TG L
Sbjct: 1157 LQLDAWDPDSSSKGKLTFNI-TSGNYMGFFMIHPVTGLL 1194
Score = 110 bits (276), Expect = 2e-23
Identities = 141/562 (25%), Positives = 243/562 (43%), Gaps = 63/562 (11%)
Query: 2332 SLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVE--DVNDNAPAFSQSLYQVMLLEHT 2389
S T L+ E D Y L + A + E A V+V D ND P FS Y+V + E
Sbjct: 102 SNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDM 161
Query: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG--- 2446
P S I V+ATD D G N Y + ++ F++ P +G + T+ G + + G
Sbjct: 162 PLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVV-TVAGKLNVTWRGKHELQ 220
Query: 2447 --AVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
AVD + + + G A VHV+ + A +A PP S T
Sbjct: 221 VLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPA---------IASVVVTPPDSNDGTT 271
Query: 2505 EATD-ADGSRSHAAVD-YSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
AT D + S A V+ ++ G+ G+ F+ A + E + LV ++ +++
Sbjct: 272 YATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFS---------LVSVKDINW 322
Query: 2563 -ESLTQYNLTVAAADRGQPPQSSVV------PVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615
E L +NL++ A P S + P ++ L F +A YRV + E +
Sbjct: 323 MEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLK-------FEKAVYRVQLSEFS 375
Query: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675
P G+ ++ V + A P +++ + + F+L+ +G + +D +A +QL
Sbjct: 376 PPGSRVVMVRVTPAFPN----LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQL 431
Query: 2676 VVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDA 2735
++ + A V I++ D N+H P F + ++ EN PPGT V + A D D
Sbjct: 432 HIRTSPGQ----ASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH 487
Query: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES-FRLLVGAADAGN-- 2792
G G + YS+ AGP F+++ G + P DYE + + V A+D G+
Sbjct: 488 GENGYVTYSI--AGP---KALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF 542
Query: 2793 -LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS 2851
V++ + + ++ P+F + + G S+ + A D D + + Y
Sbjct: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYE 600
Query: 2852 LATSS--PYFGINQTTGALYLR 2871
+ + + YF +N +G + L+
Sbjct: 601 IVSGNELEYFDLNHFSGVISLK 622
Score = 76.6 bits (187), Expect = 4e-13
Identities = 78/287 (27%), Positives = 122/287 (42%), Gaps = 20/287 (6%)
Query: 2482 FTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAG 2541
FT SHY + E+ P + + + E + AV Y IISG+ VF+ E + G
Sbjct: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYV--VG 90
Query: 2542 ESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPV 2601
R L L+ E Y L + A ++ + ++ V V +LD ND P+
Sbjct: 91 NFCFLRIRTKSSNTAL--LNREVRDSYTLIIQATEKTLELE-ALTRVVVHILDQNDLKPL 147
Query: 2602 FTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRL 2661
F+ SYRVT+ ED P+ + + V A+DAD G + F + S +F + +SG + +
Sbjct: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQN--AEFYYAFNTRSEMFAIHPTSGVVTV 205
Query: 2662 AHALDCETQARHQLVVQAAD------PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSV 2715
A L+ + +H+L V A D +LA + + V+ PA SV
Sbjct: 206 AGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAI------ASV 259
Query: 2716 AENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
P TT + DA + G +E G G+ A+ S
Sbjct: 260 VVTPPDSNDGTTYATVLVDANSSG-AEVESVEVVGGDPGKHFKAIKS 305
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 431 bits (1109), Expect = e-120
Identities = 328/1010 (32%), Positives = 481/1010 (47%), Gaps = 60/1010 (5%)
Query: 1463 ADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANA 1522
A G GP D R R P + ++RT AP+ R + L RP
Sbjct: 238 ASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPK---RMRSRGLFRCRFLPQRPGPR 294
Query: 1523 SRRRAARVSARVFVTDEN--------DNAPVFASPS-RVRLPEDQPPGPAALHVVARDPD 1573
AR AR VT N + P F + + +PE++ G A L VVA+DPD
Sbjct: 295 PPGLPARPEARK-VTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPD 353
Query: 1574 LGEAARVSYRLASGGDGH----FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR 1629
GEA R+ Y LA+ + F + +G + LDRE H L V A DHGSP
Sbjct: 354 AGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRL 413
Query: 1630 SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV 1689
SAT ++ V+VAD ND +P F+Q +Y LREN G +L LRATD D N + Y V
Sbjct: 414 SATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFV 473
Query: 1690 --------SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV-- 1739
++ +F +DP +G+++T +DRE E L V A D+G P TVRV
Sbjct: 474 GPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHI 533
Query: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAF 1798
V DEND+AP F +V E P T+ + + A+D D ANG + Y I+ G+ G F
Sbjct: 534 TVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHF 593
Query: 1799 VLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSA-TLLLTVTVLDANDHAPAFPV 1857
+D +GE + PLD E E + LRI A+D G+P LS T L ++ V+D NDH P F
Sbjct: 594 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653
Query: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL-GAGTAGAFLLEPSSGELRTAAA 1916
+ V V E+ P G ++ +QA D D G N + Y L G F++ ++G + +
Sbjct: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGP 713
Query: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976
LDRE Y F V A D + PLS + SVT+TV DVND+ P F LRL
Sbjct: 714 LDRESVEHYFFGVEARDHGSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNED---- 768
Query: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG-PRDRV 2035
+ ++ ++ A DRDA N++I Y++ G S G + + + L ++R
Sbjct: 769 AAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERY 826
Query: 2036 LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA 2095
+V T R V I R P F A ++ E+ P G+ IV A
Sbjct: 827 FKLVLTASDRALHDHCYVHINITDANTHR-PVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
Query: 2096 G-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA--- 2151
G N ITY L + F I +GAIT+++ LD+E L + A G
Sbjct: 886 DVGENARITY--LLEDNLPQFRIDADSGAITLQAP--LDYEDQVTYTLAITARDNGIPQK 941
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
T + + + D NDNAP+F+ HY + E P +LQ+ A D D + G++ Y+
Sbjct: 942 ADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQ 1001
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTN 2271
+ G F ++PT+G + T LDRE + L A DRG P L ++ VMV D N
Sbjct: 1002 NGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVN 1061
Query: 2272 DNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVDSGP---VLWYVLSPSGPQDPFSVGRY 2327
DN P P + +E+RV E++++GS +AQ+T D D GP +++ ++ + P + F + +
Sbjct: 1062 DNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIP-ELFQMDIF 1120
Query: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387
G ++ LD+E Y + + A P RA + V + D NDN+P + +Q++
Sbjct: 1121 SGELTALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN--FQILFNN 1178
Query: 2388 H------TPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTL 2431
+ T P I + A D D + S+ + V+ +G L
Sbjct: 1179 YVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGEL 1228
Score = 405 bits (1040), Expect = e-112
Identities = 313/987 (31%), Positives = 477/987 (48%), Gaps = 63/987 (6%)
Query: 1848 ANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFL 1903
AN H P FP Y VPE+ AGT +L++ A DPDAG G + Y L A + F
Sbjct: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 1904 LEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTS 1963
++P SG +RTAAALDRE + V+A D + LS T V +TV D NDH+P F +
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPR-LSATTMVAVTVADRNDHSPVFEQA 436
Query: 1964 PLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVA 2023
R L R P L L RA D DA NA++ YR G PP + EI
Sbjct: 437 QYRETL-RENVEEGYPILQL---RATDGDAPPNANLRYRFVG-PPAARAAAAAAFEIDPR 491
Query: 2024 RSPVALGPR-DRV------LFIVATDLGRPA--RSATGVIIVGLQGEAERGPRFPRASSE 2074
++ R DR L + A+D G+ RSAT + + + E + P+F
Sbjct: 492 SGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYV 551
Query: 2075 ATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLD 2133
A +RE+ P T ++ A NG + Y+I+SGN +G F+I TG I V + LD
Sbjct: 552 AQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP--LD 609
Query: 2134 FEVSPRLRLVLQAESGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGP 2189
FE L ++A+ G + + ++ + D ND+ P F+ + + E+ PL
Sbjct: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
Query: 2190 LLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
++ ++A D D G ++ YSL P F ++ TG ++ + LDRE + A
Sbjct: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP-FVINSATGWVSVSGPLDRESVEHYFFGVEA 728
Query: 2250 TDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVDSGPV 2308
D GSP L SA++TV V+D NDNRP + + LR++EDA +G+ + VT D D+
Sbjct: 729 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA 788
Query: 2309 LWYVLSPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLV 2366
+ Y ++ ++ F++ GG V+L PLD++Q ++L L A D + + +
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI 848
Query: 2367 EDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDP 2426
D N + P F + Y V + E P GS I+ +SA+D D G N I+Y L F +D
Sbjct: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
Query: 2427 NNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
++G I L ++ + + ARD+G P +A V V + D ND+AP F SH
Sbjct: 909 DSGA---ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 2487 YRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRLAEAGESAG 2545
Y V+ED PP +++L + ATD D + ++ V Y+ +G G F +EP
Sbjct: 966 YTGLVSEDAPPFTSVLQISATDRD-AHANGRVQYTFQNGEDGDGDFTIEP---------- 1014
Query: 2546 PGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA 2605
G + + LD E+++ Y LT A DRG PP + V + V V DVNDN PVF
Sbjct: 1015 ----TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
Query: 2606 SYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHAL 2665
+ V V E++ VG+ + + A D D GP+ + + + G+ LF++D SG L L
Sbjct: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
Query: 2666 DCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF-PLNLLSTSVAENQP---P 2721
D E + + +VVQA + + A V + + D ND+ P +L + N+ P
Sbjct: 1131 DYEARQEYVIVVQAT--SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP 1188
Query: 2722 GTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESF 2781
++ + A D D L YS E G + +N ++GELR D
Sbjct: 1189 SGIIGRIPAYDPDVS--DHLFYS-FERG---NELQLLVVNQTSGELRLSRKLDNNRPLVA 1242
Query: 2782 RLLVGAADA-GNLSASVTVSVLVTGED 2807
+LV D +++A + V++ E+
Sbjct: 1243 SMLVTVTDGLHSVTAQCVLRVVIITEE 1269
Score = 376 bits (966), Expect = e-103
Identities = 304/986 (30%), Positives = 472/986 (47%), Gaps = 68/986 (6%)
Query: 998 PRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSP---FGLEPQS 1051
P+F Y+ +P AGT VL+V AQ PD G + Y LAA S F ++PQS
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1052 GWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTF 1111
G + AALDRE+ E + L+V A L + T V V++ ++N+HSP +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRL---SATTMVAVTVADRNDHSPVFEQAQYR 439
Query: 1112 LAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL----QQLSEDSKAFRIHPQTGEVTTLQ 1167
+ EN G + ++ ATD D+ PN L Y + + AF I P++G ++T
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
Query: 1168 TLDREQQSSYQLLVQVQDGGSPP--RSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
+DRE SY+L+V+ D G P RS T VH+ VLD NDN+P F + A Q
Sbjct: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA------Q 553
Query: 1226 VPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSELFSLHPHSGELLTAAPLIRAER 1284
V + V P T+V + A D D+ NG + Y + +G F++ +GE+ APL
Sbjct: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
Query: 1285 PHYVLTLSAHDQGSPPRSASLQLL-VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
Y L + A D G PP S + L +QV+ D+ + P V V+ E
Sbjct: 614 REYALRIRAQDAGRPPLSNNTGLASIQVV----------DINDHIPIF-VSTPFQVSVLE 662
Query: 1344 GLRPG-SLLGSVAAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPP 1401
G S++ A G A L Y+L G A P+ F +++A+G + ++ PLD E+
Sbjct: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVA-PDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 1402 WR-ALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRA 1460
+ + R G A V V V D N++ P F L L E+ G ++ + A
Sbjct: 722 YFFGVEARDHGSPPLSASA-SVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA 780
Query: 1461 SDADGPGPNSDVRYRLLRQEPPVP-ALRLDARTGALSAPRGLDRETTPALLLLVEATDRP 1519
D D NS + Y++ A+ G ++ LD + L++ A+DR
Sbjct: 781 VDRDA---NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
Query: 1520 ANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAA 1578
+ + +TD N + PVF S V + ED+P G + + A D D+GE A
Sbjct: 838 LHD------HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENA 891
Query: 1579 RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
R++Y L FR+ + +GA+++ PLD E + + L + A D+G P ++ T + V
Sbjct: 892 RITYLLEDNLP-QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVM 950
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES----F 1694
V DVND AP F Y+ L+ E+ PP TS+L + ATD D ANG+V Y + E F
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDF 1010
Query: 1695 SLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754
+++P +G++ T+R LDRE LT YA DRG PP T V+++V V+D ND+AP F +
Sbjct: 1011 TIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
Query: 1755 HLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPL 1813
+ V E + + A DPD G N + Y+I++G+ F +D+ SGE + L
Sbjct: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
Query: 1814 DREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP-----VPAYSVEVPEDV 1868
D E + + ++A L + + V ++D ND++P Y +
Sbjct: 1131 DYEARQEYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTF 1187
Query: 1869 PAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL-EPSSGELRTAAALDREQCPSYTF 1927
P+G ++ ++ A+DPD + H+ Y G L+ +SGELR + LD + +
Sbjct: 1188 PSG-IIGRIPAYDPDV--SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASM 1244
Query: 1928 SVSAVDGAAAGPLSTTVSVTITVRDV 1953
V+ DG + + V I ++
Sbjct: 1245 LVTVTDGLHSVTAQCVLRVVIITEEL 1270
Score = 360 bits (923), Expect = 2e-98
Identities = 309/936 (33%), Positives = 441/936 (47%), Gaps = 65/936 (6%)
Query: 51 IDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
+ E + AGT + + A P AG A L+Y ++A S +ID SG++RTA LDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 110 EQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYP 163
E +R+ D AT V V VAD NDH+P F QA+ + E+ G YP
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEG--YP 451
Query: 164 LEPAR--DADAGRLGTQGYALSGD-----GAGETFRLETRPGPDGTPVPELVVTGELDRE 216
+ R D DA Y G A F ++ R G T +G +DRE
Sbjct: 452 ILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST-------SGRVDRE 504
Query: 217 NRSHYMLQLEAYDGGSP--PRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPV 274
+ Y L +EA D G PR A + +T+LD ND+AP F++ RY A V E + P + V
Sbjct: 505 HMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVV 564
Query: 275 LQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA 334
L+V A+D D NG V Y I S G F+ID+ TG +Q+ PLDFE R + L ++A
Sbjct: 565 LRVTATDRDKDANGLVHYNIISGNSRGH--FAIDSLTGEIQVVAPLDFEAEREYALRIRA 622
Query: 335 RDGGAHP-ELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDP 393
+D G P + ++ V D ND+ P IF+S V E AP G V I D
Sbjct: 623 QDAGRPPLSNNTGLASIQVVDINDHIP----IFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
Query: 394 DDGDFAHVNVSLEG--GEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451
D G+ A + SL G + F + +S V V+ LDRE + Y V A D GSPP
Sbjct: 679 DHGENARLEYSLTGVAPDTPFVI---NSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
Query: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS 511
L A A+ + V DVNDN P F + Y L E A G+ VV VTA D D N ++Y
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLR-LNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 512 LAPGAHTHWFSIDPTSGI--ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
+ G + F+I G+ +T A LDY+ E +L++ A+D L V + +
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINIT 849
Query: 570 DVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPF 629
D N + P FQ Y+ S+ E G+ + ++A+D D G ++Y L L P F
Sbjct: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-----PQF 904
Query: 630 RIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYP 687
RIDA SG + LD + ++ +TA D G YV+V ++D NDN PQF
Sbjct: 905 RIDADSGAITLQAPLDYED-QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVA 963
Query: 688 REYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGLLTVAW 746
Y +S +PP T+VL++ A D D ++GR+ Y G + FT++ SG++
Sbjct: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
Query: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
L R A SV +L A D G + + + P+F ++ V E+ G
Sbjct: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
Query: 807 TSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEV 865
+ V + A +P G A + + G+ LF +D SG L L LD E + + V
Sbjct: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV-IVV 1142
Query: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYTLRALDP 921
+A S P + A V V L D NDNSP + + V +T P I + A DP
Sbjct: 1143 QATSA--PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP 1200
Query: 922 DSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPL 956
D V+ + ++ G V+ T+G +RL R L
Sbjct: 1201 D--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKL 1234
Score = 350 bits (899), Expect = 1e-95
Identities = 295/935 (31%), Positives = 437/935 (46%), Gaps = 54/935 (5%)
Query: 482 LPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH---WFSIDPTSGIITTAASLDY 538
+PE G+ V+RV A+DPD G G++ YSLA ++ FSIDP SG+I TAA+LD
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 539 ELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL 598
E + L V A D G P L+++ V+V + D ND+ P F++ Y +L E + G L
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
Query: 599 QVTATDADSGPFGLLSYSLGA--GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFT 656
Q+ ATD D+ P L Y ++ + F ID SG + T+ +DR+ S++
Sbjct: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH-MESYELV 512
Query: 657 VTAVDGG---GLKSM-VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDP 712
V A D G G +S V V + + DENDN PQF + Y A + P T VLR+ A D
Sbjct: 513 VEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDR 572
Query: 713 DQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQ-AE 771
D+ ++G + Y+I++GNS F +D +G + V PL A L I A+D G +
Sbjct: 573 DKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSN 632
Query: 772 PSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG 830
+ I +V PIF + SV E+ G SV +QA + G A + SL+G
Sbjct: 633 NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG 692
Query: 831 GDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
P F +++ +G + PLDRE + G PP A A V V + DVNDN
Sbjct: 693 VAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDN 752
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG---AFTVDPTT 947
P F E + L + A GT + ++ A+D D+ NS +++ + G A +
Sbjct: 753 RPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGV 810
Query: 948 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
G V L PL +L L A D H + + + D T P F S Y V
Sbjct: 811 GLVTLALPLDYKQERYFKLVLTASDRALH---DHCYVHINITDANTH--RPVFQSAHYSV 865
Query: 1008 DLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREA 1064
+ G+ ++ + A D G ITY L E F ++ SG + ++A LD E
Sbjct: 866 SVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYED 923
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
Q Y L + A + Q+ T V V + + N+++P+ V+E+ PP TSV
Sbjct: 924 QVTYTLAITARDNG---IPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
Query: 1125 GRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQ 1184
++ ATDRD+ NGR+ Y+ Q + F I P +G V T++ LDRE S Y+L
Sbjct: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
Query: 1185 DGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDP 1244
D G PP T ++ V V D+NDN+P F ++V + G++V + A DP
Sbjct: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVF------PAEEFEVRVKENSIVGSVVAQITAVDP 1094
Query: 1245 DEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSA 1303
DEG N I+Y + G ELF + SGEL L R YV+ + A
Sbjct: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA---------T 1145
Query: 1304 SLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL---TVTAAEGLRPGSLLGSVAAPEPA 1360
S L+ + RL D + P +L V+ P ++G + A +P
Sbjct: 1146 SAPLVSRATVHVRLV----DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
Query: 1361 GVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
L Y+ G + + ++ SG L L+R LD
Sbjct: 1202 VSDHLFYSFERGNELQ-LLVVNQTSGELRLSRKLD 1235
Score = 349 bits (896), Expect = 2e-95
Identities = 270/860 (31%), Positives = 395/860 (45%), Gaps = 39/860 (4%)
Query: 141 PAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY---ALSGDGAGETFRLETRP 197
P FPQ VPE+ A GT A+D DAG G Y AL + E F ++ +
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQ 257
G T LDRE+ + L++ A D GSP A ++ VT+ D NDH+P F Q
Sbjct: 383 GLIRT-------AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 258 SRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEI---NRRQSEGDGPFSIDAHTGLL 314
++Y + E++ G P+LQ+ A+D DA N + Y ++ F ID +GL+
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVH--VRDANDNQPSMTVIFLSADGS 372
+D E +ELVV+A D G P SA V VH V D NDN P F
Sbjct: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQ----FSEKRYV 551
Query: 373 PQVSEAAPPGQLVARISVS--DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRL 430
QV E P +V R++ + D D H N+ GHFA+ DS+ + V L
Sbjct: 552 AQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI---DSLTGEIQVVAPL 608
Query: 431 DREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPG 489
D E Y LR+ A D+G PPL + V D+ND+ P F ++ L L G
Sbjct: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL-G 667
Query: 490 SFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
V+ + A D D G N ++ YSL A F I+ +G ++ + LD E V
Sbjct: 668 HSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
Query: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
A D G PPL++SA+V+V + DVNDN P+F Y+ L E GT + VTA D D+
Sbjct: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
Query: 610 FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMV 669
+SY + G + F I G T L D + V L
Sbjct: 787 -SAISYQI---TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHC 842
Query: 670 YVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNS 729
YV + ++D N + P F Y+ S++ P G+ ++ + A D D G + R++Y L ++
Sbjct: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY--LLEDN 900
Query: 730 PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
P F +D SG +T+ PL L I A D G Q + V++ + P
Sbjct: 901 LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
Query: 790 FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGG-DPRGLFSLDAVSGLLQ 847
F Y V ED P TSV + A + V + G D G F+++ SG+++
Sbjct: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
Query: 848 TLRPLDRELLGPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPN 906
T+R LDRE + V EL A GVPP ++V++ DVNDN+P FPA E V + N
Sbjct: 1021 TVRRLDREAVS-VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
Query: 907 TAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHE 965
+ G+ + + A+DPD G N+ + + ++ G F +D +G + + L +
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
Query: 966 LELEARDGGSPPR-TSHFRL 984
+ ++A R T H RL
Sbjct: 1140 IVVQATSAPLVSRATVHVRL 1159
Score = 326 bits (836), Expect = 2e-88
Identities = 272/915 (29%), Positives = 418/915 (45%), Gaps = 60/915 (6%)
Query: 1962 TSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIR 2021
T+P R LP G S S P L A A A +A R A P P G R
Sbjct: 228 TAPRRNCLP--GASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSR--GLFR 283
Query: 2022 VARSPVALGPRDRVLFIVATDLGRP-ARSATGVIIVGLQGEAERGPRFPRASSEATIREN 2080
P GPR L RP AR T + A R P+FP+ + + + EN
Sbjct: 284 CRFLPQRPGPRPPGL------PARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPEN 337
Query: 2081 APPGTPIVSPRAVHA-GGTNGPITYSI---LSGNEKGTFSIQPSTGAITVRSAEGLDFEV 2136
GT ++ A G G + YS+ ++ FSI P +G I R+A LD E
Sbjct: 338 EAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLI--RTAAALDRES 395
Query: 2137 SPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQV 2193
R L + A+ G+ A T++ +T+ D ND++P F + Y L E+ P+LQ+
Sbjct: 396 MERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQL 455
Query: 2194 EADDLDQGSGGQISYSL----AASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
A D D + Y AA A F +DP +G I+T+ +DRE LV+ A
Sbjct: 456 RATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEA 515
Query: 2250 TDRGSPALVGSATLTV--MVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGND--VD 2304
+D+G SAT+ V V+D NDN P + + +V ED + + +VT D D
Sbjct: 516 SDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKD 575
Query: 2305 SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV 2364
+ ++ Y + + F++ G + + PLDFE Y L++ A D +N T
Sbjct: 576 ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635
Query: 2365 L----VEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPAD 2420
L V D+ND+ P F + +QV +LE+ P G +++ + A D D G N + Y L A
Sbjct: 636 LASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAP 695
Query: 2421 GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAP 2480
N+ T + V L + +EARDHG+P +A A+V V + D ND+ P
Sbjct: 696 DTPFVINSATGWVSVSG-PLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRP 754
Query: 2481 SFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEA 2540
FT+ Y + + ED G++++++ A D D +++A+ Y I GN F + +
Sbjct: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRD---ANSAISYQITGGNTRNRFAISTQ---- 807
Query: 2541 GESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPP 2600
+G + L PLD++ + L + A+DR V + + D N + P
Sbjct: 808 --------GGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYV---HINITDANTHRP 856
Query: 2601 VFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLR 2660
VF A Y V+V ED P+G+ ++ + ASD D G + + + + P F +D SG +
Sbjct: 857 VFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAIT 914
Query: 2661 LAHALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQ 2719
L LD E Q + L + A D A V + V DVND+ P F + + V+E+
Sbjct: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDA 974
Query: 2720 PPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTE 2779
PP T V + A D DA A GR++Y+ G +G F + ++G +R D E
Sbjct: 975 PPFTSVLQISATDRDAHANGRVQYTFQN---GEDGDGDFTIEPTSGIVRTVRRLDREAVS 1031
Query: 2780 SFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA 2837
+ L A D G L V++ V+V ++ PVF A F +V E + G + + A
Sbjct: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
Query: 2838 TDEDGGADGLVLYSL 2852
D D G + ++Y +
Sbjct: 1092 VDPDEGPNAHIMYQI 1106
Score = 301 bits (770), Expect = 9e-81
Identities = 287/1016 (28%), Positives = 446/1016 (43%), Gaps = 73/1016 (7%)
Query: 554 GLPPLASSATVSVA----LQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
GLP + V+ A + + PQF + Y +PE GT L+V A D D+G
Sbjct: 297 GLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGE 356
Query: 610 FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKS 667
G L YSL A + S F ID SG + T LDR+ + VTA D G L +
Sbjct: 357 AGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSPRLSA 415
Query: 668 MVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILA- 726
V V ++D ND+ P F +Y ++ G +L+LRA D D + L Y +
Sbjct: 416 TTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGP 475
Query: 727 ----GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSA--RVDISI 780
+ F +D +SGL++ + + R +L + A D G SA RV I++
Sbjct: 476 PAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITV 535
Query: 781 VPGTPTPPIFEQLQYVFSVPEDVAPGTSV-GIVQAHNPPGRLAPVTLSLSGGDPRGLFSL 839
+ P F + +YV V EDV P T V + V ++ G+ RG F++
Sbjct: 536 LDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI 595
Query: 840 DAVSGLLQTLRPLDRELLGPVLELEVRA-GSGVPPA---FAVARVRVLLDDVNDNSPAFP 895
D+++G +Q + PLD E L +RA +G PP +A ++V+ D+ND+ P F
Sbjct: 596 DSLTGEIQVVAPLDFE-AEREYALRIRAQDAGRPPLSNNTGLASIQVV--DINDHIPIFV 652
Query: 896 APEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL-AGGGGAFTVDPTTGHVRLMR 954
+ V + N G + ++A+D D G N+R+ ++L F ++ TG V +
Sbjct: 653 STPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG 712
Query: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTT 1014
PL + +EARD GSPP ++ + V V DV P F Y + L
Sbjct: 713 PLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDN--RPEFTMKEYHLRLNEDAA 770
Query: 1015 AGTQVLQVQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVM 1073
GT V+ V A D I+Y + + F + Q G V AL + ++ K++
Sbjct: 771 VGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLV 830
Query: 1074 AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD 1133
+ +A V ++I + N H P ++V E++P G+++ + A+D D
Sbjct: 831 LTASDRA----LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886
Query: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
G N R+TY L+ ++ FRI +G +T LD E Q +Y L + +D G P ++
Sbjct: 887 VGENARITYLLE---DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKAD 943
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
T V V V D+NDN+P F+ AS G V + PP T V + A D D NG +
Sbjct: 944 TTYVEVMVNDVNDNAPQFV-ASHYTG-----LVSEDAPPFTSVLQISATDRDAHANGRVQ 997
Query: 1254 YTLTG--PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPP--RSASLQLLV 1309
YT G F++ P SG + T L R Y LT A D+G PP S+Q++V
Sbjct: 998 YTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMV 1057
Query: 1310 QVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTY 1367
Q D+ + P P V E GS++ + A +P G A + Y
Sbjct: 1058 Q------------DVNDNAPVFPAE-EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMY 1104
Query: 1368 TLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQ 1427
+V G PE F +D SG L LD+EA + + P + A V V++
Sbjct: 1105 QIVEGNIPE-LFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRA---TVHVRLV 1160
Query: 1428 DENEHAPAFARDPLA----LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPV 1483
D+N+++P + ++ + P + A D D SD + + +
Sbjct: 1161 DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD----VSDHLFYSFERGNEL 1216
Query: 1484 PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
L ++ +G L R LD +LV TD + + + RV V +T+E
Sbjct: 1217 QLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV---VIITEE 1269
Score = 291 bits (745), Expect = 7e-78
Identities = 223/687 (32%), Positives = 319/687 (46%), Gaps = 43/687 (6%)
Query: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGA-------TVEVTVRVADINDHAPAFPQ 145
AID +G ++ LD E Y D T +++V DINDH P F
Sbjct: 594 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653
Query: 146 ARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP 205
+ V E+ G A DAD G Y+L+G F + + G
Sbjct: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATG------- 706
Query: 206 ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVS 265
+ V+G LDRE+ HY +EA D GSPP A A + VT+LD+ND+ P F YH ++
Sbjct: 707 WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN 766
Query: 266 ESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQR 325
E A G+ V+ V A D DA N A++Y+I + S GL+ L PLD++Q
Sbjct: 767 EDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQE 824
Query: 326 RVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLV 385
R +LV+ A D H +V +++ DAN ++P +F SA S V+E P G +
Sbjct: 825 RYFKLVLTASDRALHDH---CYVHINITDANTHRP----VFQSAHYSVSVNEDRPMGSTI 877
Query: 386 ARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
IS SD D G+ A + LE F + I L LD E++ Y L +TA
Sbjct: 878 VVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL---QAPLDYEDQVTYTLAITAR 934
Query: 446 DSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504
D+G P +A+ +V + V DVNDNAP F Y + E A P + V++++A D D
Sbjct: 935 DNGIPQ-KADTTYVEVMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHA 992
Query: 505 NGQVTYSLAPGAHTHW-FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSAT 563
NG+V Y+ G F+I+PTSGI+ T LD E +L A D G+PPL + +
Sbjct: 993 NGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVS 1052
Query: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGS 623
+ V +QDVNDN P F + + E + G+ Q+TA D D GP + Y + G
Sbjct: 1053 IQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEG--- 1109
Query: 624 SGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
+ F++D SG++ T +D D V L S V V L D+NDN P
Sbjct: 1110 NIPELFQMDIFSGEL--TALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSP 1167
Query: 684 -----QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQ 738
Q Y ++ S P G + R+ A+DPD H L Y GN L +++
Sbjct: 1168 VLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQT 1224
Query: 739 SGLLTVAWPLARRANSVVQLEIGAEDG 765
SG L ++ L V + + DG
Sbjct: 1225 SGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 248 bits (632), Expect = 9e-65
Identities = 183/620 (29%), Positives = 307/620 (49%), Gaps = 43/620 (6%)
Query: 2272 DNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPV--LWYVLSP---SGPQDPFSVG 2325
+ P PQ ++ V E+ G+ + +V D D+G L Y L+ S + FS+
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLA--HDGPHEGRANLT-VLVEDVNDNAPAFSQSLYQ 2382
G + LD E +R+ L++ A H P + V V D ND++P F Q+ Y+
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
Query: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP-------ADGFSVDPNNGTLFTIV 2435
L E+ G IL + ATD D+ N ++ Y P A F +DP +G + T
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS- 498
Query: 2436 GTVALGHDGSGAVDVVLEARDHGA-PG-RAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
G V H S ++V+EA D G PG R+A VH+ + D+ND+AP F+ Y V E
Sbjct: 499 GRVDREHMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
Query: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGC 2553
D+ P + +L + ATD D ++ V Y+IISGN F ++ E
Sbjct: 557 DVRPHTVVLRVTATDRDKD-ANGLVHYNIISGNSRGHFAIDSLTGE-------------- 601
Query: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV-TVTVLDVNDNPPVFTRASYRVTVP 2612
+ ++ PLDFE+ +Y L + A D G+PP S+ + ++ V+D+ND+ P+F ++V+V
Sbjct: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
Query: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
E+ P+G ++H++A DAD G + + ++++ P F ++ ++G + ++ LD E+
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 2673 HQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAI 2731
+ V+A D A A VT+ V DVND+ P F + + E+ GT V ++ A+
Sbjct: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 2732 DGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791
D DA + + Y + G R A + G + +P DY+ F+L++ A+D
Sbjct: 782 DRDANS--AISYQI--TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
Query: 2792 NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS 2851
L V + +T + + PVF + + V E G ++ + A+D+D G + + Y
Sbjct: 838 -LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYL 896
Query: 2852 LATSSPYFGINQTTGALYLR 2871
L + P F I+ +GA+ L+
Sbjct: 897 LEDNLPQFRIDADSGAITLQ 916
Score = 167 bits (424), Expect = 1e-40
Identities = 140/459 (30%), Positives = 209/459 (45%), Gaps = 53/459 (11%)
Query: 2480 PSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR---VFQLEPR 2536
P F +Y+ V E+ G+ +L + A D D + V YS+ + R +F ++P+
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLV-YSLAALMNSRSLELFSIDPQ 381
Query: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596
G + LD ES+ ++ L V A D G P S+ V VTV D N
Sbjct: 382 S--------------GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT-----VSSGDPSGLFE 2651
D+ PVF +A YR T+ E+ G +L + A+D D P+ +R+ + + FE
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
Query: 2652 LDESSGTLRLAHALDCETQARHQLVVQAADPA---GAHFALAPVTIEVQDVNDHGPAFPL 2708
+D SG + + +D E ++LVV+A+D G A V I V D ND+ P F
Sbjct: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE 547
Query: 2709 NLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELR 2768
V E+ P T+V + A D D A G + Y+++ R FA++S TGE++
Sbjct: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGN----SRGHFAIDSLTGEIQ 603
Query: 2769 ARVPFDYEHTESFRLLVGAADAGNLSASVTV---SVLVTGEDEYDPVFLAPAFHFQVPEG 2825
P D+E + L + A DAG S S+ V +++ P+F++ F V E
Sbjct: 604 VVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLEN 663
Query: 2826 ARRGHSLGHVQATDEDGGADGLVLYSLATSSP--YFGINQTTGALYLRVDSRAPGSGTAT 2883
A GHS+ H+QA D D G + + YSL +P F IN TG + +
Sbjct: 664 APLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSV------------- 710
Query: 2884 SGGGGRTRREAPRELRLEVIAR--GPLPGSRSATVPVTV 2920
G RE+ V AR G P S SA+V VTV
Sbjct: 711 ---SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTV 746
Score = 81.6 bits (200), Expect = 1e-14
Identities = 68/221 (30%), Positives = 97/221 (43%), Gaps = 10/221 (4%)
Query: 2704 PAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSS 2763
P FP T V EN+ GT V + A D DAG GRL YSL A E F+++
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLA-ALMNSRSLELFSIDPQ 381
Query: 2764 TGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ 2821
+G +R D E E L V A D G+ LSA+ V+V V +++ PVF +
Sbjct: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
Query: 2822 VPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGT 2881
+ E G+ + ++ATD D + + Y + A +D P SG
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAA----RAAAAAAFEID---PRSGL 494
Query: 2882 ATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDI 2922
++ G EL +E +G PG RSATV V + +
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITV 535
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 425 bits (1092), Expect = e-118
Identities = 317/943 (33%), Positives = 473/943 (50%), Gaps = 63/943 (6%)
Query: 1852 APAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFLLEPS 1907
AP F P+Y VPE+ PAGT + L+A DPD G G + Y + A + F L+P
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 1908 SGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL 1967
+G + TA LDRE ++ F V+A D S ++TI V D NDH P F +
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMPRR-SALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL----AGTPPPGTTVDSYTGEIRVA 2023
L R L T+RA D DA NA+ILYRL G+P +D +G IR
Sbjct: 297 SL-RENLEVGYEVL---TVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT- 351
Query: 2024 RSPVALGPRDRV----LFIVATDLGRPA--RSATGVIIVGLQGEAERGPRFPRASSEATI 2077
R PV R+ V L + A+D GR RS T + + ++ + + P+F +
Sbjct: 352 RGPV---DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 2078 RENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEV 2136
RE+ PG P++ A G+N + YSI+SGN +G F + TGA+ V S LD+E
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYET 466
Query: 2137 SPRLRLVLQAESGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQ 2192
+ L ++A+ GG + ++T+ + D NDNAP F+ + A + ES PL +L
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
Query: 2193 VEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDR 2252
V+A D D G ++ Y LA F ++ TG I+ A LDRE + A D
Sbjct: 527 VQAIDADAGDNARLEYRLAGVGHDFP-FTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWY 2311
G+PAL SA+++V V+D NDN PT QP + +R++EDA +G+ + V+ D D+ V+ Y
Sbjct: 586 GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITY 645
Query: 2312 VLSPSGPQDPFSVGRY--GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDV 2369
++ ++ FS+ GG VSL PLD++ +Y L + A DG + A + V V D
Sbjct: 646 QITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDA 705
Query: 2370 NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNG 2429
N + P F S Y V + E P G+ ++ +SATD D+G N I+Y + F +D + G
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG 765
Query: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489
+ T L ++ + + + ARD+G P ++ + + + D ND+AP F Y+
Sbjct: 766 AVTT---QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
Query: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPR 2549
+V ED+PP +++L + ATD D SG GRVF + G+
Sbjct: 823 SVYEDVPPFTSVLQISATDRD-------------SGLNGRVFYTFQG-GDDGDGDFIVES 868
Query: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRV 2609
G + L LD E++ QY L A D+G PP + + VTVTVLDVNDNPPVF + + V
Sbjct: 869 TSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
Query: 2610 TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET 2669
V E++P+G + V A+D D G + + + + G+ +F+LD SG L LD E
Sbjct: 929 FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
Query: 2670 QARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF-PLNLLSTSVAENQP---PGTLV 2725
+ + LV+QA + + A V + + D ND+ P +L + N+ PG +
Sbjct: 989 RPEYVLVIQAT--SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAI 1046
Query: 2726 TTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELR 2768
+ A D D L YS E G LN+STGEL+
Sbjct: 1047 GRVPAHDPDIS--DSLTYS-FERG---NELSLVLLNASTGELK 1083
Score = 402 bits (1034), Expect = e-111
Identities = 316/987 (32%), Positives = 467/987 (47%), Gaps = 71/987 (7%)
Query: 889 DNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA----GGGGAFTVD 944
+ +P F P +P N GTP+ +LRA+DPD G R+ +T+ A F++D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 945 PTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPT 1004
P TG V L H + A+D G P R++ L ++V D T P F
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD--TNDHDPVFEQQE 293
Query: 1005 YRVDLPSGTTAGTQVLQVQA---QAPDGGPITYHLAAEGASSP---FGLEPQSGWLWVRA 1058
Y+ L G +VL V+A AP I Y L SP F ++P+SG + R
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 1059 ALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQ 1118
+DRE E Y L V A S + G ++ TA V +S+ + N+++P+ SE + V E+
Sbjct: 354 PVDREEVESYQLTVEA-SDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 1119 PPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQ 1178
PG V RV A+DRD G N + YS+ + + F + QTG + + LD E Y
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQ-FYLDAQTGALDVVSPLDYETTKEYT 471
Query: 1179 LLVQVQDGGSPPRST-TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVT 1237
L V+ QDGG PP S +G V V VLD+NDN+P F+ A V + VP G LV
Sbjct: 472 LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA------TVLESVPLGYLVL 525
Query: 1238 TLQAKDPDEGENGTILYTLTGPGSEL-FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296
+QA D D G+N + Y L G G + F+++ +G + AA L R E Y + A D
Sbjct: 526 HVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA 1356
G+P +AS + V VL D+ + +P P TV E G+ + +V+A
Sbjct: 586 GTPALTASASVSVTVL----------DVNDNNPTFTQPEY-TVRLNEDAAVGTSVVTVSA 634
Query: 1357 PEPAGVGALTYTLVGGADPEGTFALDAASGR--LYLARPLDFEAGPPWRALTVRAEGPGG 1414
+ +TY + G + F++ + SG + LA PLD++ + ++G
Sbjct: 635 VDRDAHSVITYQITSG-NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ 693
Query: 1415 AGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRY 1474
A+++ V V D N H P F + + E+ G + A+D D G N+ + Y
Sbjct: 694 DTAQIV---VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITY 749
Query: 1475 RLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARV 1534
+ E +P R+DA TGA++ LD E + L + A D N +++ +
Sbjct: 750 FM---EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYLEI 803
Query: 1535 FVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG--GDGH 1591
V D NDNAP F S + + ED PP + L + A D D G RV Y G GDG
Sbjct: 804 LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD 863
Query: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
F + S++G + +R LDRE A++VL A D G PP +TV+V DVND P F+Q
Sbjct: 864 FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
Query: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA 1708
E+ V + EN+P G ++ + ATDPD G N Q+ Y G E F LD +G LT L
Sbjct: 924 DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVD 983
Query: 1709 LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL---------SLE 1759
LD E++ E L + A S P ++ TV V + D ND+ P G+ + S
Sbjct: 984 LDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSS 1040
Query: 1760 VPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEP 1819
P G + + A DPD+ + L Y G+ +L+ ++GE R LD P
Sbjct: 1041 FPGG----AIGRVPAHDPDI--SDSLTYSFERGNELSLVLLNASTGELKLSRALDNN-RP 1093
Query: 1820 AFQLRIEARDGGQPALSATLLLTVTVL 1846
+ G +++A L VT++
Sbjct: 1094 LEAIMSVLVSDGVHSVTAQCALRVTII 1120
Score = 378 bits (971), Expect = e-104
Identities = 315/938 (33%), Positives = 438/938 (46%), Gaps = 55/938 (5%)
Query: 43 QAGSLDLQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV 101
Q S + E QPAGT + + A P G A L Y + A S ++D +G V
Sbjct: 182 QPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV 241
Query: 102 RTARVLDREQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEH 155
TA LDRE + + F D A +T+ V D NDH P F Q + E+
Sbjct: 242 TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYAL---SGDGAGETFRLETRPGPDGTPVPELVVTGE 212
G A D DA Y L SG E F ++ R G T G
Sbjct: 302 LEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT-------RGP 354
Query: 213 LDRENRSHYMLQLEAYDGGSP--PRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270
+DRE Y L +EA D G PR A + +++ D ND+AP F++ RY V E + P
Sbjct: 355 VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
Query: 271 GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330
G+PVL+V ASD D G N V Y I G F +DA TG L + PLD+E + + L
Sbjct: 415 GAPVLRVTASDRDKGSNAVVHYSI--MSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
Query: 331 VVQARDGGAHPELG-SAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARIS 389
V+A+DGG P S VTV V D NDN P IF+S V E+ P G LV +
Sbjct: 473 RVRAQDGGRPPLSNVSGLVTVQVLDINDNAP----IFVSTPFQATVLESVPLGYLVLHVQ 528
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
D D GD A + L G GH T ++ + VA LDREE D Y+ V A D G+
Sbjct: 529 AIDADAGDNARLEYRL-AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGT 587
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
P L A A+ + V DVNDN P F + Y L E A G+ VV V+A D D + +T
Sbjct: 588 PALTASASVSVTVLDVNDNNPTFTQPEYTVR-LNEDAAVGTSVVTVSAVDRD--AHSVIT 644
Query: 510 YSLAPGAHTHWFSIDPTS--GIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVA 567
Y + G + FSI S G+++ A LDY+LE Q L V A+DG +A + V
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVN 701
Query: 568 LQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSP 627
+ D N + P FQ + Y ++ E GT + ++ATD D+G ++Y + P
Sbjct: 702 VTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIP 756
Query: 628 PFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQF 685
FRIDA +G V T LD + S+ +TA D G Y+++ ++D NDN PQF
Sbjct: 757 QFRIDADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
Query: 686 YPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGLLTV 744
Y S+ PP T+VL++ A D D G +GR+ Y G + F ++ SG++
Sbjct: 816 LRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
Query: 745 AWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVA 804
L R + L A D G A V ++++ PP+FEQ ++ V E+
Sbjct: 876 LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935
Query: 805 PGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLEL 863
G +V V A +P G A + + G+ +F LD SG L L LD E P L
Sbjct: 936 IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYE-DRPEYVL 994
Query: 864 EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYTLRAL 919
++A S P + A V V L D NDN P E + V ++ PG I + A
Sbjct: 995 VIQATSA--PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
Query: 920 DPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPL 956
DPD ++ +T++ G ++ +TG ++L R L
Sbjct: 1053 DPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRAL 1088
Score = 370 bits (950), Expect = e-101
Identities = 311/946 (32%), Positives = 450/946 (47%), Gaps = 49/946 (5%)
Query: 467 DNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS---LAPGAHTHWFSI 523
+ AP F Y+ +PE G+ V + A DPD+G G++ Y+ L +FS+
Sbjct: 176 NTAPQFQPPSYQAT-VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
Query: 524 DPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFY 583
DP +G +TTA LD E + V A D G+P ++ AT+++ + D ND++P F++ Y
Sbjct: 235 DPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 584 NASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT 643
SL E + G L V ATD D+ P + Y L G G S S F ID SG + T
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 644 LDRDQGPSSFDFTVTAVDGG---GLKSMVYVKVFLS--DENDNPPQFYPREYAASISAQS 698
+DR++ S+ TV A D G G +S VFLS D+NDN PQF + Y +
Sbjct: 355 VDREE-VESYQLTVEASDQGRDPGPRSTT-AAVFLSVEDDNDNAPQFSEKRYVVQVREDV 412
Query: 699 PPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQL 758
PG VLR+ A D D+GS+ + Y I++GN+ F LD Q+G L V PL L
Sbjct: 413 TPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTL 472
Query: 759 EIGAEDGGGLQ-AEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN- 816
+ A+DGG + S V + ++ PIF + +V E V G V VQA +
Sbjct: 473 RVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 817 PPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFA 876
G A + L+G F+++ +G + LDRE + G P A
Sbjct: 533 DAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTA 592
Query: 877 VARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG 936
A V V + DVNDN+P F PE TV L + A GT + T+ A+D D+ +S +T+ + +G
Sbjct: 593 SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG 650
Query: 937 GGG---AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGT 993
+ T G V L PL + L + A DG R ++ V V D T
Sbjct: 651 NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANT 707
Query: 994 RGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQ 1050
P F S Y V++ AGT V+ + A D G ITY + E + F ++
Sbjct: 708 H--RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM--EDSIPQFRIDAD 763
Query: 1051 SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPT 1110
+G + +A LD E Q Y L A++ + Q++ T + + + + N+++P+ D
Sbjct: 764 TGAVTTQAELDYEDQVSYTL---AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
Query: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170
+V E+ PP TSV ++ ATDRDSG NGR+ Y+ Q + F + +G V TL+ LD
Sbjct: 821 QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLD 880
Query: 1171 REQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRV 1230
RE + Y L D G PP T V V VLD+NDN P F Q + V +
Sbjct: 881 RENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDE------FDVFVEENS 934
Query: 1231 PPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289
P G V + A DPDEG N I+Y + G E+F L SGEL L +RP YVL
Sbjct: 935 PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
Query: 1290 TLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGS 1349
+ A S P + + V++L + PP L + + VT PG
Sbjct: 995 VIQA---TSAPLVSRATVHVRLLDR---NDNPPVLGNFE----ILFNNYVTNRSSSFPGG 1044
Query: 1350 LLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
+G V A +P +LTY+ G + L+A++G L L+R LD
Sbjct: 1045 AIGRVPAHDPDISDSLTYSFERG-NELSLVLLNASTGELKLSRALD 1089
Score = 355 bits (912), Expect = 3e-97
Identities = 306/979 (31%), Positives = 450/979 (45%), Gaps = 56/979 (5%)
Query: 1433 APAFARDPLALALPENPEPGAALYTFRASDAD-GPGPNSDVRYRLLRQEPPVPALRLDAR 1491
AP F +PEN G + + RA D D G + L LD
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 1492 TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS- 1550
TGA++ LDRET + V A D + RR+A + + VTD ND+ PVF
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 1551 RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH----FRLHSSTGALSVVRP 1606
+ L E+ G L V A D D A + YRL G G F + +G + P
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 1607 LDREQRAEHVLTVVASDHGSPP--RSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPP 1664
+DRE+ + LTV ASD G P RS T + +SV D ND AP F ++ Y V +RE+ P
Sbjct: 355 VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
Query: 1665 GTSLLTLRATDPDVGANGQVTYGGVSSES---FSLDPDTGVLTTLRALDREEQEEINLTV 1721
G +L + A+D D G+N V Y +S + F LD TG L + LD E +E L V
Sbjct: 415 GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
Query: 1722 YAQDRGSPPQLTHVT--VRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPD 1778
AQD G PP L++V+ V V V D ND+AP F S V E L + ++A D D
Sbjct: 475 RAQDGGRPP-LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 1779 VGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSAT 1838
G N +L+YR+ F ++ +G LDRE + +EARD G PAL+A+
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
Query: 1839 LLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG- 1897
++VTVLD ND+ P F P Y+V + ED GT ++ + A D D A+ +TY + +G
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGN 651
Query: 1898 TAGAFLLEPSSGE--LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVND 1955
T F + SG + A LD + Y +V+A DG T + + V D N
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT 707
Query: 1956 HAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDS 2015
H P F +S + + P+ +T L AT D D G NA I Y + + P +D+
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISAT----DEDTGENARITYFMEDSIPQ-FRIDA 762
Query: 2016 YTGEIRVARSPVALGPRDRV---LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRAS 2072
TG + + L D+V L I A D G P +S T + + + + P+F R S
Sbjct: 763 DTGAV---TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS 819
Query: 2073 SEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNE-KGTFSIQPSTGAITVRSAE 2130
+ ++ E+ PP T ++ A G NG + Y+ G++ G F ++ ++G VR+
Sbjct: 820 YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG--IVRTLR 877
Query: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVL--TLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187
LD E V+ + + G A T + T+T+ D NDN P F + + F+ E+ P+
Sbjct: 878 RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247
+ +V A D D+G+ QI Y + +F +D +G +T LD E E LV+
Sbjct: 938 LAVARVTATDPDEGTNAQIMYQIVEGNIPE-VFQLDIFSGELTALVDLDYEDRPEYVLVI 996
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVS------EDALLGSEIAQVTGN 2301
AT S LV AT+ V ++D NDN P + +E+ + + G I +V +
Sbjct: 997 QAT---SAPLVSRATVHVRLLDRNDNPPVLGN-FEILFNNYVTNRSSSFPGGAIGRVPAH 1052
Query: 2302 DVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN 2361
D D L Y + G + L+ LD + + +L DG H A
Sbjct: 1053 DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQ 1112
Query: 2362 LTVLVEDVNDNAPAFSQSL 2380
+ V + D S +L
Sbjct: 1113 CALRVTIITDEMLTHSITL 1131
Score = 342 bits (878), Expect = 3e-93
Identities = 300/984 (30%), Positives = 440/984 (44%), Gaps = 69/984 (7%)
Query: 1748 APTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYR---ILDGDPSGAFVLDLA 1803
AP F VPE Q T + LRA DPD G G+L+Y + D + F LD
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVE 1863
+G T LDRE + R+ A+D G P SA LT+ V D NDH P F Y
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA----FLLEPSSGELRTAAALDR 1919
+ E++ G +L ++A D DA N ++ Y L G+ G+ F ++P SG +RT +DR
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDR 357
Query: 1920 EQCPSYTFSVSAVD-GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFST 1978
E+ SY +V A D G GP STT +V ++V D ND+AP F +++ T
Sbjct: 358 EEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED----VT 413
Query: 1979 PTLALATLRAEDRDAGANASILYRL-AGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
P + + A DRD G+NA + Y + +G +D+ TG + V ++ L
Sbjct: 414 PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
Query: 2038 IVATDLGRPARS-ATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA- 2095
+ A D GRP S +G++ V + + P F +AT+ E+ P G ++ +A+ A
Sbjct: 474 VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N + Y + F+I TG I+V A LD E ++A G A T
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISV--AAELDREEVDFYSFGVEARDHGTPALT 591
Query: 2156 V---LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA 2212
+++T+ D NDN P F +P Y L E + ++ V A D D S I+Y + +
Sbjct: 592 ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITS 649
Query: 2213 SQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
R F + +G + L + E + VL T +A + V V D N
Sbjct: 650 GN-TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANT 707
Query: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPV--LWYVLSPSGPQDPFSVGRYGG 2329
+RP + + V+ED G+ + ++ D D+G + Y + S PQ F + G
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTG 765
Query: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLT---VLVEDVNDNAPAFSQSLYQVMLL 2386
V+ LD+E Y L + A D +++ T +LV DVNDNAP F + YQ +
Sbjct: 766 AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADG---FSVDPNNGTLFTIVGTVALGHD 2443
E PP +++L +SATDRDSG NG + Y DG F V+ +G + T+ D
Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL-----D 880
Query: 2444 GSGAVDVVLEAR--DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTL 2501
VL A D G P V V + D ND+ P F + V V E+ P G +
Sbjct: 881 RENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940
Query: 2502 LTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLD 2561
+ ATD D ++A + Y I+ GN VFQL+ E L L LD
Sbjct: 941 ARVTATDPDEG-TNAQIMYQIVEGNIPEVFQLDIFSGE--------------LTALVDLD 985
Query: 2562 FESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR----VTVPEDTPV 2617
+E +Y L + A P S V V +LD NDNPPV VT +
Sbjct: 986 YEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP 1042
Query: 2618 GAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVV 2677
G + V A D D + ++ G+ L L+ S+G L+L+ ALD + V
Sbjct: 1043 GGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100
Query: 2678 QAADPAGAHFALAPVTIEVQDVND 2701
+D G H A + V + D
Sbjct: 1101 LVSD--GVHSVTAQCALRVTIITD 1122
Score = 342 bits (877), Expect = 4e-93
Identities = 307/976 (31%), Positives = 436/976 (44%), Gaps = 52/976 (5%)
Query: 140 APAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY---ALSGDGAGETFRLETR 196
AP F VPE+ GT A D D G G Y AL + + F L+
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD-- 235
Query: 197 PGPDGTPVPELVVTGE-LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF 255
PV V T E LDRE +S ++ ++ A D G P R A A L + + D NDH P F
Sbjct: 236 ------PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 256 NQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP---FSIDAHTG 312
Q Y + E+L G VL V A+D DA N + Y + + G P F ID +G
Sbjct: 290 EQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRL--LEGSGGSPSEVFEIDPRSG 347
Query: 313 LLQLERPLDFEQRRVHELVVQARDGGAH--PELGSAFVTVHVRDANDNQPSMTVIFLSAD 370
+++ P+D E+ ++L V+A D G P +A V + V D NDN P F
Sbjct: 348 VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ----FSEKR 403
Query: 371 GSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG--EGHFALSTQDSVIYLVCVAR 428
QV E PG V R++ SD D G A V+ S+ G G F L Q + +V
Sbjct: 404 YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVV---S 460
Query: 429 RLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVAL 487
LD E Y LRV A D G PPL + V + V D+NDNAP F ++ L V L
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
Query: 488 PGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLI 547
G V+ V A D D G N ++ Y LA H F+I+ +G I+ AA LD E
Sbjct: 521 -GYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
Query: 548 VVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADS 607
V A D G P L +SA+VSV + DVNDN P F + Y L E GT + V+A D D+
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
Query: 608 GPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD-QGPSSFDFTVTAVDGGGLK 666
+++Y + +G + F I + SG + L D + + VTA D G +
Sbjct: 640 --HSVITYQITSG---NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQ 693
Query: 667 SMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILA 726
+ V ++D N + P F Y +++ P GT V+ + A D D G + R++Y +
Sbjct: 694 DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-- 751
Query: 727 GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 786
+S P F +D +G +T L L I A D G Q + ++I +
Sbjct: 752 EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDN 811
Query: 787 PPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDP-RGLFSLDAVSG 844
P F + Y SV EDV P TSV + A G V + GGD G F +++ SG
Sbjct: 812 APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG 871
Query: 845 LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904
+++TLR LDRE + + G+PPA V V + DVNDN P F E V +
Sbjct: 872 IVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVE 931
Query: 905 PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963
N+ G + + A DPD G N+++ + ++ G F +D +G + + L P
Sbjct: 932 ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPE 991
Query: 964 HELELEARDGGSPPR-TSHFRLRVVVQDVGTRG-LAPRFNSPTYRVDLPSGTTAGTQVLQ 1021
+ L ++A R T H RL + G FN+ V S + G + +
Sbjct: 992 YVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNN---YVTNRSSSFPGGAIGR 1048
Query: 1022 VQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080
V A PD +TY S L +G L + ALD I+ V+ G
Sbjct: 1049 VPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG--- 1105
Query: 1081 ELGQQTGTATVRVSIL 1096
+ T +RV+I+
Sbjct: 1106 -VHSVTAQCALRVTII 1120
Score = 337 bits (864), Expect = 1e-91
Identities = 285/908 (31%), Positives = 409/908 (45%), Gaps = 51/908 (5%)
Query: 74 APLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPD--------GA 125
A ++Y + G ID SGV+RT +DRE+ + Y+ T D
Sbjct: 322 ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRST 381
Query: 126 TVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGD 185
T V + V D ND+AP F + R +QV E G A D D G Y++
Sbjct: 382 TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSG 441
Query: 186 GAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPP-RRAQALLDVT 244
A F L+ + G L V LD E Y L++ A DGG PP L+ V
Sbjct: 442 NARGQFYLDAQTG-------ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQ 494
Query: 245 LLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP 304
+LDIND+AP F + + A V ES+ G VL V A DADAG N + Y + D P
Sbjct: 495 VLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL--AGVGHDFP 552
Query: 305 FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTV 364
F+I+ TG + + LD E+ + V+ARD G SA V+V V D NDN P+
Sbjct: 553 FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPT--- 609
Query: 365 IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLV 424
F + + +++E A G V +S D D ++ F++++Q S LV
Sbjct: 610 -FTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQ-SGGGLV 667
Query: 425 CVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPE 484
+A LD + Y L VTA+D + A V++VTD N + P F Y + E
Sbjct: 668 SLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVN-VNE 723
Query: 485 VALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP 544
G+ VV ++A D D G N ++TY + F ID +G +TT A LDYE +
Sbjct: 724 DRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSY 781
Query: 545 QLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATD 604
L + A D G+P + + + + + DVNDN PQF R Y S+ E P T LQ++ATD
Sbjct: 782 TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 605 ADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG- 663
DSG G + Y+ G G F +++ SG V T R LDR + + + AVD G
Sbjct: 842 RDSGLNGRVFYTFQG--GDDGDGDFIVESTSGIVRTLRRLDR-ENVAQYVLRAYAVDKGM 898
Query: 664 -GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSY 722
++ + V V + D NDNPP F E+ + SP G AV R+ A DPD+G++ ++ Y
Sbjct: 899 PPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMY 958
Query: 723 HILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVP 782
I+ GN P +F LD SG LT L L I A A V + ++
Sbjct: 959 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLD 1015
Query: 783 GTPTPPIFEQLQYVF----SVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFS 838
PP+ + +F + PG ++G V AH+ P +T S G+ L
Sbjct: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD-PDISDSLTYSFERGNELSLVL 1074
Query: 839 LDAVSGLLQTLRPLDREL-LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897
L+A +G L+ R LD L ++ + V G A RV ++ D++ +S
Sbjct: 1075 LNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLE 1134
Query: 898 E---DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMR 954
+ + L P + A PD V V A GG V + G +
Sbjct: 1135 DMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVG-----Q 1189
Query: 955 PLGPSGGP 962
P GP GGP
Sbjct: 1190 PPGPGGGP 1197
Score = 334 bits (856), Expect = 1e-90
Identities = 263/832 (31%), Positives = 387/832 (46%), Gaps = 51/832 (6%)
Query: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYS---ILSGNEKGTFSIQPST 2121
P+F S +AT+ EN P GTP+ S RA+ G G + Y+ + FS+ P T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2122 GAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVA 2178
GA+T +AE LD E + A+ G A LT+ + D ND+ P F + Y
Sbjct: 239 GAVT--TAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSL---AASQPARGLFHVDPTTGTITTTAIL 2235
L E+ + +L V A D D I Y L + P+ +F +DP +G I T +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE-VFEIDPRSGVIRTRGPV 355
Query: 2236 DREIWAETRLVLMATDRGSPALVGSATLTVM--VIDTNDNRPTIPQP-WELRVSEDALLG 2292
DRE +L + A+D+G S T V V D NDN P + + ++V ED G
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 2293 SEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350
+ + +VT +D D G V+ Y + + F + G + + PLD+E Y L++
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
Query: 2351 AHDGPHEGRANL----TVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406
A DG +N+ TV V D+NDNAP F + +Q +LE P G +L V A D D+G
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 2407 ANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARA 2466
N + Y LA F NNGT + V L + +EARDHG P A A
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 2467 TVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526
+V V + D ND+ P+FT Y V + ED G++++T+ A D D +H+ + Y I SGN
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD---AHSVITYQITSGN 651
Query: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586
F + +S G G + L PLD++ QY L V A+D + + +V
Sbjct: 652 TRNRFSI------TSQSGG------GLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIV 699
Query: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646
V V D N + PVF + Y V V ED P G ++ + A+D D G + + + + P
Sbjct: 700 ---VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP 756
Query: 2647 SGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPA 2705
F +D +G + LD E Q + L + A D + + I V DVND+ P
Sbjct: 757 Q--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQ 814
Query: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765
F + SV E+ PP T V + A D D+G GR+ Y+ G +G F + S++G
Sbjct: 815 FLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG---GDDGDGDFIVESTSG 871
Query: 2766 ELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQVP 2823
+R D E+ + L A D G A + V VT D D PVF F V
Sbjct: 872 IVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVE 931
Query: 2824 EGARRGHSLGHVQATDEDGGADGLVLYSLATSS--PYFGINQTTGALYLRVD 2873
E + G ++ V ATD D G + ++Y + + F ++ +G L VD
Sbjct: 932 ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVD 983
Score = 322 bits (826), Expect = 3e-87
Identities = 292/949 (30%), Positives = 427/949 (44%), Gaps = 66/949 (6%)
Query: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010
R+VN AP F + +P P+ TP +A+LRA D D G + Y +
Sbjct: 173 RNVNT-APQFQPPSYQATVPENQPA-GTP---VASLRAIDPDEGEAGRLEYTMDALFDSR 227
Query: 2011 T----TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGP 2066
+ ++D TG + A V + A D G P RSA + + + + P
Sbjct: 228 SNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDP 287
Query: 2067 RFPRASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGN---EKGTFSIQPSTG 2122
F + + ++REN G +++ RA N I Y +L G+ F I P +G
Sbjct: 288 VFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG 347
Query: 2123 AITVRSAEGLDFEVSPRLRLVLQA-----ESGGAFAFTVLTLTLQDANDNAPRFLRPHYV 2177
I R +D E +L ++A + G + L+++D NDNAP+F YV
Sbjct: 348 VIRTRGP--VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYV 405
Query: 2178 AFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDR 2237
+ E P+L+V A D D+GS + YS+ + ARG F++D TG + + LD
Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN-ARGQFYLDAQTGALDVVSPLDY 464
Query: 2238 EIWAETRLVLMATDRGSPALVG-SATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEI 2295
E E L + A D G P L S +TV V+D NDN P + P++ V E LG +
Sbjct: 465 ETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV 524
Query: 2296 AQVTGNDVDSGPV--LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD 2353
V D D+G L Y L+ G PF++ G +S+ LD E+ D Y + A D
Sbjct: 525 LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD 584
Query: 2354 GPHEG---RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
A+++V V DVNDN P F+Q Y V L E G+++++VSA DRD A+
Sbjct: 585 HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSV 642
Query: 2411 ISYHLAS--PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468
I+Y + S + FS+ +G ++AL D VL R A +
Sbjct: 643 ITYQITSGNTRNRFSITSQSGGGLV---SLALPLDYKLERQYVLAVTASDGT-RQDTAQI 698
Query: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG 2528
V + D N H P F SHY V V ED P G+T++ + ATD D + +A + Y
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED-TGENARITYF------- 750
Query: 2529 RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV 2588
+E + + A G + LD+E Y L + A D G P +S +
Sbjct: 751 ----MEDSIPQFRIDADTG-----AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801
Query: 2589 TVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS- 2647
+ V DVNDN P F R SY+ +V ED P +L + A+D D G +G V +T GD
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
Query: 2648 GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAP--VTIEVQDVNDHGPA 2705
G F ++ +SG +R LD E A++ L A D G A P VT+ V DVND+ P
Sbjct: 862 GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK-GMPPARTPMEVTVTVLDVNDNPPV 920
Query: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765
F + V EN P G V + A D D G ++ Y ++E G PE F L+ +G
Sbjct: 921 FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE-GNIPE---VFQLDIFSG 976
Query: 2766 ELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVF--LAPAFHFQVP 2823
EL A V DYE + L++ A A L + TV V + ++ PV F+ V
Sbjct: 977 ELTALVDLDYEDRPEYVLVIQATSA-PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVT 1035
Query: 2824 EGARR--GHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
+ G ++G V A D D + +N +TG L L
Sbjct: 1036 NRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKL 1084
Score = 131 bits (330), Expect = 1e-29
Identities = 144/493 (29%), Positives = 206/493 (41%), Gaps = 44/493 (8%)
Query: 43 QAGSLDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV 101
Q+ + ++E++PAGT + ISA G A + YF+ ID +G V
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSI-----PQFRIDADTGAV 767
Query: 102 RTARVLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEH 155
T LD E + Y D T + + V D+ND+AP F + V E
Sbjct: 768 TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYED 827
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSG--DGAGETFRLETRPGPDGTPVPELVVTGEL 213
T A D D+G G Y G DG G+ F +E+ G T L
Sbjct: 828 VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD-FIVESTSGIVRT-------LRRL 879
Query: 214 DRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSP 273
DREN + Y+L+ A D G PP R + VT+LD+ND+ P F Q + V E+ G
Sbjct: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
Query: 274 VLQVFASDADAGVNGAVTYEINRRQSEGDGP--FSIDAHTGLLQLERPLDFEQRRVHELV 331
V +V A+D D G N + Y+I EG+ P F +D +G L LD+E R + LV
Sbjct: 940 VARVTATDPDEGTNAQIMYQI----VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLV 995
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391
+QA P + A V V + D NDN P + + + ++ PG + R+
Sbjct: 996 IQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
Query: 392 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451
DPD D + S E G +L ++ + ++R LD + V +D G
Sbjct: 1053 DPDISD--SLTYSFERG-NELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHS 1108
Query: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPE---VALPGSFVVRVT---ARDPDQGTN 505
+ A+ A L VT + D L + PE L G F+ V A PD
Sbjct: 1109 VTAQCA--LRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVV 1166
Query: 506 GQVTYSL-APGAH 517
V APG H
Sbjct: 1167 FNVQRDTDAPGGH 1179
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 414 bits (1065), Expect = e-115
Identities = 335/1018 (32%), Positives = 483/1018 (47%), Gaps = 86/1018 (8%)
Query: 1468 PNSDVRYRLL---RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASR 1524
P VR RLL R+ + L P + P L EA PA +R
Sbjct: 175 PGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRAR 234
Query: 1525 R-RAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSY 1582
R + R S + F P+ +V L E++P G L + A GE RVSY
Sbjct: 235 RGTSGRGSLK------------FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSY 282
Query: 1583 RLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
+ D G+FR+ S+TGA+S LDRE + HVL V A D+ +PPRSAT +TV
Sbjct: 283 YMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVL 342
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG--GVSSESFSL 1696
V D ND +P F+Q EY +REN G +LT+RA+D D N + Y G + + F L
Sbjct: 343 VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQL 402
Query: 1697 DPDTGVLTTLRALDREEQEEINLTVYAQDRG--SPPQLTHVTVRVAVEDENDHAPTFGSA 1754
+ +GV++T LDREE E L V A D+G P TV + VEDEND+ P F
Sbjct: 403 NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
Query: 1755 HLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPL 1813
+ ++VPE T + ++A+D D G N + Y IL G+ +G F L SG + PL
Sbjct: 463 NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPL 522
Query: 1814 DREVEPAFQLRIEARDGGQPAL-SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGT 1872
D E + L I+A+DGG+P L +++ +++V VLD ND+ P F + V E+VP G
Sbjct: 523 DFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY 582
Query: 1873 LLLQLQAHDPDAGANGHVTY--------YLGAGTAG----------AFLLEPSSGELRTA 1914
++ +QA D D+G N + Y +LG G+AG F + SSG +
Sbjct: 583 PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC 642
Query: 1915 AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 1974
A LDRE+ Y+F V AVD + P+S++ SV+ITV DVND+ P F LRL
Sbjct: 643 AELDREEVEHYSFGVEAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAA 701
Query: 1975 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYT-------GEIRVARSPV 2027
S ++ TL+A DRD AN+ I Y+L G G T + + G I +A +
Sbjct: 702 VGS----SVLTLQARDRD--ANSVITYQLTG----GNTRNRFALSSQRGGGLITLA---L 748
Query: 2028 ALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI 2087
L + +++A RS T +++ + P F + ++ E+ P GT I
Sbjct: 749 PLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
Query: 2088 VSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA 2146
+ A G N ITY I + F I P +G T+ + LD+E L + A
Sbjct: 809 ATLSANDEDTGENARITYVI--QDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMA 864
Query: 2147 ESGG---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG 2203
+ G T L + + DANDNAP+FL Y + E P +LQV A D D G
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 2204 GQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPA-LVGSAT 2262
G++ Y+ G F+++PT+G I T LDRE A L +A DRGSP L S
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVE 984
Query: 2263 LTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQ 2319
+ V ++D NDN P + EL V E+ +GS +A++ ND D GP + Y + +
Sbjct: 985 IQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMR 1044
Query: 2320 DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQS 2379
F + G + LDFE Y L + A P RA + +L+ D NDN P
Sbjct: 1045 HFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD- 1103
Query: 2380 LYQVMLLEHTP------PGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTL 2431
+Q++ + P I + A D D + + ++ + +DP G L
Sbjct: 1104 -FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGEL 1160
Score = 414 bits (1065), Expect = e-115
Identities = 306/991 (30%), Positives = 492/991 (49%), Gaps = 72/991 (7%)
Query: 1855 FPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFLLEPSSGE 1910
FP+P Y V + E+ PAGTL+LQL AH G V+YY+ + G F ++ ++G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 1911 LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLP 1970
+ T + LDRE ++ V AVD + P S T +T+ V+D NDH+P F S R R+
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRERV- 362
Query: 1971 RPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG 2030
R L T+RA DRD+ NA++ YR+ G ++ +G +
Sbjct: 363 RENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
Query: 2031 PRDRVLFIVATDLGRPAR--SATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
+ L + A D GR SAT + + ++ E + P+F + + E+ T ++
Sbjct: 420 AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
Query: 2089 SPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147
+A G N I YSILSGN G F + +G + V + LDFE + L ++A+
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIKAQ 537
Query: 2148 SGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG 2203
GG V+++ + D NDN P F+ + A + E+ PL P++ ++A D D G
Sbjct: 538 DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 2204 GQISYSLAAS-------------QPARGL---FHVDPTTGTITTTAILDREIWAETRLVL 2247
++ Y L + PA F + ++G IT A LDRE +
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSG 2306
A D GSP + S ++++ V+D NDN P QP +ELR++EDA +GS + + D D+
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN 717
Query: 2307 PVLWYVLSPSGPQDPFSVG--RYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV 2364
V+ Y L+ ++ F++ R GG ++L PLD++Q +Y L + A DG A++ +
Sbjct: 718 SVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLI 777
Query: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSV 2424
V D N + P F S Y V + E P G++I ++SA D D+G N I+Y + P F +
Sbjct: 778 NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRI 837
Query: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL 2484
DP++GT++T+ + L ++ A + + A+D+G P ++ T+ + + D ND+AP F
Sbjct: 838 DPDSGTMYTM---MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLW 894
Query: 2485 SHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG-RVFQLEPRLAEAGES 2543
Y+ ++ ED PP +++L + ATD D S + + Y+ G+ G F +EP
Sbjct: 895 DFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDDGDGDFYIEP-------- 945
Query: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVF 2602
G + LD E++ YNL A DRG P P S+ V + VT+LD+NDN P+F
Sbjct: 946 ------TSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
Query: 2603 TRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLA 2662
+ + V E+ PVG+ + + A+D D GP+ + + + GD F+LD +G LR
Sbjct: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM 1059
Query: 2663 HALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFP-----LNLLSTSVAE 2717
LD E + + LVVQA + + A V I + D ND+ P P N T+ +
Sbjct: 1060 VELDFEVRREYVLVVQAT--SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 1117
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
+ P G ++ + A D D L Y+ ++ G E R L+ +TGEL+ D
Sbjct: 1118 SFPTG-VIGCIPAHDPDVS--DSLNYTFVQ---GNELR-LLLLDPATGELQLSRDLDNNR 1170
Query: 2778 TESFRLLVGAADA-GNLSASVTVSVLVTGED 2807
+ V +D +++A T+ V + +D
Sbjct: 1171 PLEALMEVSVSDGIHSVTAFCTLRVTIITDD 1201
Score = 354 bits (909), Expect = 7e-97
Identities = 315/1035 (30%), Positives = 477/1035 (46%), Gaps = 87/1035 (8%)
Query: 992 GTRGLAP-RFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAA---EGASSP 1044
GT G +F P Y+V L AGT +LQ+ A G ++Y++ E +
Sbjct: 236 GTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGY 295
Query: 1045 FGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPR 1104
F ++ +G + + LDRE +E ++L+V AV S ++ T + V + + N+HSP
Sbjct: 296 FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLVKDTNDHSPV 352
Query: 1105 LSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVT 1164
+ V EN G V + A+DRDS N L Y + + D F+++ +G V+
Sbjct: 353 FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVS 410
Query: 1165 TLQTLDREQQSSYQLLVQVQDGGSPPR--STTGTVHVAVLDLNDNSPTFLQASGAAGGGL 1222
T LDRE+ + YQLLV+ D G P S T TV++ V D NDN P F + +
Sbjct: 411 TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYV----- 465
Query: 1223 PIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT-LTGPGSELFSLHPHSGELLTAAPLIR 1281
+QVP+ V T V +QA D D+G+N I Y+ L+G + F LH SG L PL
Sbjct: 466 -VQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDF 524
Query: 1282 AERPHYVLTLSAHDQGSPPR-SASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340
+ Y L++ A D G PP ++S + VQVL D+ + +P V T
Sbjct: 525 EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVL----------DVNDNEPIF-VSSPFQAT 573
Query: 1341 AAEGLRPGSLLGSVAAPEP-AGVGALTY--------TLVGGAD---------PEGTFALD 1382
E + G + + A + +G A + T +GG P+ F +
Sbjct: 574 VLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH 633
Query: 1383 AASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLA 1442
+SG + + LD E + + + V + V D N++ P F +
Sbjct: 634 NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYE 693
Query: 1443 LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP-ALRLDARTGALSAPRGL 1501
L L E+ G+++ T +A D D NS + Y+L AL G ++ L
Sbjct: 694 LRLNEDAAVGSSVLTLQARDRDA---NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
Query: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPP 1560
D + +L V A+D +R A V + VTD N + PVF S V + ED+P
Sbjct: 751 DYKQEQQYVLAVTASD----GTRSHTAHVL--INVTDANTHRPVFQSSHYTVSVSEDRPV 804
Query: 1561 GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620
G + + A D D GE AR++Y + FR+ +G + + LD E + + LT++
Sbjct: 805 GTSIATLSANDEDTGENARITYVIQDPVP-QFRIDPDSGTMYTMMELDYENQVAYTLTIM 863
Query: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
A D+G P +S T L + + D ND AP F Y + E+ PP TS+L + ATD D G
Sbjct: 864 AQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP 923
Query: 1681 NGQVTY----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLT-HV 1735
NG++ Y G F ++P +GV+ T R LDRE NL A DRGSP L+ V
Sbjct: 924 NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
Query: 1736 TVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDP 1794
++V + D ND+AP F L L V E + +RA+DPD G N Q+ Y+I++GD
Sbjct: 984 EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
Query: 1795 SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPA 1854
F LDL +G+ M LD EV + L ++A L + + + ++D ND+ P
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPV 1100
Query: 1855 FP-----VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSG 1909
P Y P G + + AHDPD + + T+ G LL+P++G
Sbjct: 1101 LPDFQILFNNYVTNKSNSFPTGVIGC-IPAHDPDVSDSLNYTFVQG-NELRLLLLDPATG 1158
Query: 1910 ELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969
EL+ + LD + VS DG + T+ VTI D+ T+ + +RL
Sbjct: 1159 ELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDM-------LTNSITVRL 1211
Query: 1970 PRPG-PSFSTPTLAL 1983
F +P LAL
Sbjct: 1212 ENMSQEKFLSPLLAL 1226
Score = 343 bits (880), Expect = 2e-93
Identities = 303/989 (30%), Positives = 451/989 (45%), Gaps = 70/989 (7%)
Query: 53 EEQPAGTLIGDISAGLPA-GTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ 111
E +PAGTLI + A G + Y++ ID +G V T VLDRE
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 112 RDRY--RFTAVT----PDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLE 165
++ + R AV P AT +TV V D NDH+P F Q+ +V E+ G
Sbjct: 316 KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
Query: 166 PARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQL 225
A D D+ Y + G GA + F+L G T LDRE + Y L +
Sbjct: 376 RASDRDSPINANLRYRVLG-GAWDVFQLNESSGVVST-------RAVLDREEAAEYQLLV 427
Query: 226 EAYDGG--SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDAD 283
EA D G P A A + + + D ND+ P F++ Y V E + + VL+V A+D D
Sbjct: 428 EANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRD 487
Query: 284 AGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPEL 343
G N A+ Y I G F + + +G+L + PLDFE + + L ++A+DGG P +
Sbjct: 488 QGQNAAIHYSI--LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLI 545
Query: 344 GSA-FVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVN 402
S+ V+V V D NDN+P IF+S+ V E P G V I D D G+ A ++
Sbjct: 546 NSSGVVSVQVLDVNDNEP----IFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
Query: 403 VSLEGGEGHF----------ALSTQDSVIYL------VCVARRLDREERDAYNLRVTATD 446
L F T D + + V LDREE + Y+ V A D
Sbjct: 602 YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
Query: 447 SGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNG 506
GSPP+ + + + V DVNDN P F + Y L E A GS V+ + ARD D N
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELR-LNEDAAVGSSVLTLQARDRD--ANS 718
Query: 507 QVTYSLAPGAHTHWFSIDPT--SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564
+TY L G + F++ G+IT A LDY+ E Q L V A+DG + +A V
Sbjct: 719 VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHV 775
Query: 565 SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624
+ + D N + P FQ + Y S+ E GT ++A D D+G ++Y +
Sbjct: 776 LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QD 830
Query: 625 GSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNP 682
P FRID SG + T LD + ++ T+ A D G +++ + D NDN
Sbjct: 831 PVPQFRIDPDSGTMYTMMELDY-ENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 683 PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGL 741
PQF Y SI +PP T++L++ A D D G +GRL Y G + F ++ SG+
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 742 LTVAWPLARRANSVVQL-EIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVP 800
+ L R +V L + + G S + ++I+ P+FE+ + V
Sbjct: 950 IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
Query: 801 EDVAPGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP 859
E+ G+ V ++A++P G A + + GD R F LD ++G L+ + LD E+
Sbjct: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
Query: 860 VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYT 915
+ L V+A S P + A V +LL D NDN P P + + V N+ P I
Sbjct: 1070 YV-LVVQATSA--PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
Query: 916 LRALDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDG- 973
+ A DPD V+ + +T + G +DP TG ++L R L + +E+ DG
Sbjct: 1127 IPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
Query: 974 GSPPRTSHFRLRVVVQDVGTRGLAPRFNS 1002
S R+ ++ D+ T + R +
Sbjct: 1185 HSVTAFCTLRVTIITDDMLTNSITVRLEN 1213
Score = 336 bits (861), Expect = 3e-91
Identities = 293/966 (30%), Positives = 429/966 (44%), Gaps = 61/966 (6%)
Query: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGD-GPFSIDAHTGL 313
F Y + E+ G+ +LQ+ A G V+Y + E G F ID+ TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 314 LQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSP 373
+ + LD E + H L V+A D P + ++TV V+D ND+ P +F ++
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP----VFEQSEYRE 360
Query: 374 QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGH-FALSTQDSVIYLVCVARRLDR 432
+V E G V I SD D A++ + GG F L+ V+ V LDR
Sbjct: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV---LDR 417
Query: 433 EERDAYNLRVTATDSG--SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
EE Y L V A D G PL A A + V D NDN P F Q Y + +V L +
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL-NT 476
Query: 491 FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVA 550
V+RV A D DQG N + YS+ G F + SGI+ LD+E + L + A
Sbjct: 477 AVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
Query: 551 TDGGLPPLA-SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
DGG PPL SS VSV + DVNDNEP F + + A++ E G + + A DADSG
Sbjct: 537 QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 610 FGLLSYS--------LGAGLGSSGSP------PFRIDAHSGDVCTTRTLDRDQGPSSFDF 655
L Y LG G +P PF+I SG + LDR++ + F
Sbjct: 597 NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF 655
Query: 656 TVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD 713
V AVD G + S V + + D NDN P F Y ++ + G++VL L+A D D
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 714 QGSHGRLSYHILAGNSPPLFTLDEQ--SGLLTVAWPLARRANSVVQLEIGAEDGGGLQAE 771
S ++Y + GN+ F L Q GL+T+A PL + L + A DG
Sbjct: 716 ANS--VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRS 770
Query: 772 PSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN-PPGRLAPVTLSLSG 830
+A V I++ P+F+ Y SV ED GTS+ + A++ G A +T +
Sbjct: 771 HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ- 829
Query: 831 GDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
DP F +D SG + T+ LD E + +G+P + +L+ D NDN
Sbjct: 830 -DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG--GGGAFTVDPTTG 948
+P F + + P T I + A D DSG N R+ +T G G G F ++PT+G
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
Query: 949 HVRLMRPLGPSGGPAHELELEARDGGSP-PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
+R R L + L A D GSP P ++ ++V + D+ AP F +
Sbjct: 949 VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDN--APMFEKDELEL 1006
Query: 1008 DLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREA 1064
+ G+ V +++A PD GP I Y + F L+ +G L LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV 1066
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDP----TFLAVAENQPP 1120
+ Y+L V A S ATV + +++QN++ P L + ++ N P
Sbjct: 1067 RREYVLVVQATS------APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
Query: 1121 GTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLL 1180
+G + A D D + L Y+ Q + + + P TGE+ + LD + +
Sbjct: 1121 TGVIGCIPAHDPDVSDS--LNYTFVQ-GNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
Query: 1181 VQVQDG 1186
V V DG
Sbjct: 1178 VSVSDG 1183
Score = 326 bits (835), Expect = 3e-88
Identities = 282/927 (30%), Positives = 417/927 (44%), Gaps = 57/927 (6%)
Query: 1377 GTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAF 1436
G F +D+A+G + LD E + + + V V+D N+H+P F
Sbjct: 294 GYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVF 353
Query: 1437 ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALS 1496
+ + EN E G + T RASD D P N+++RYR+L V +L+ +G +S
Sbjct: 354 EQSEYRERVRENLEVGYEVLTIRASDRDSP-INANLRYRVLGGAWDV--FQLNESSGVVS 410
Query: 1497 APRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSR-VRLP 1555
LDRE LLVEA D+ N +A + + V DENDN P F+ + V++P
Sbjct: 411 TRAVLDREEAAEYQLLVEANDQGRNPG-PLSATATVYIEVEDENDNYPQFSEQNYVVQVP 469
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAE 1614
ED A L V A D D G+ A + Y + SG G F LHS +G L V+ PLD E +
Sbjct: 470 EDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
Query: 1615 HVLTVVASDHGSPPR-SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673
+ L++ A D G PP +++ V++V V DVND P F + + EN P G ++ ++A
Sbjct: 530 YSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQA 589
Query: 1674 TDPDVGANGQVTYGGVSSES--------------------FSLDPDTGVLTTLRALDREE 1713
D D G N ++ Y V + S F + +G +T LDREE
Sbjct: 590 VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE 649
Query: 1714 QEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQTLTML 1772
E + V A D GSPP + +V + V D ND+ P F L + E ++ L
Sbjct: 650 VEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTL 709
Query: 1773 RASDPDVGANGQLQYRILDGDPSGAFVL--DLASGEFGTMRPLDREVEPAFQLRIEARDG 1830
+A D D AN + Y++ G+ F L G PLD + E + L + A DG
Sbjct: 710 QARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG 767
Query: 1831 GQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHV 1890
+ S T + + V DAN H P F Y+V V ED P GT + L A+D D G N +
Sbjct: 768 TR---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARI 824
Query: 1891 TYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950
TY + F ++P SG + T LD E +YT ++ A D S T ++ I +
Sbjct: 825 TYVI-QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILI 882
Query: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010
D ND+AP F + + P P+ ++ + A DRD+G N +LY G
Sbjct: 883 LDANDNAPQFLWDFYQGSIFEDAP----PSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
Query: 2011 TT--VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPA-RSATGVIIVGLQGEAERGPR 2067
++ +G IR R L+ +A D G P SA+ I V + + P
Sbjct: 939 GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998
Query: 2068 FPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITV 2126
F + E + EN P G+ + RA G N I Y I+ G+ + F + G +
Sbjct: 999 FEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNG--DL 1056
Query: 2127 RSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAP-----RFLRPHYVAFLP 2181
R+ LDFEV LV+QA S + + + L D NDN P + L +YV
Sbjct: 1057 RAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKS 1116
Query: 2182 ESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWA 2241
S P G + + A D D ++Y+ R L +DP TG + + LD
Sbjct: 1117 NSFP-TGVIGCIPAHDPDVSD--SLNYTFVQGNELR-LLLLDPATGELQLSRDLDNNRPL 1172
Query: 2242 ETRLVLMATDRGSPALVGSATLTVMVI 2268
E + + +D G ++ TL V +I
Sbjct: 1173 EALMEVSVSD-GIHSVTAFCTLRVTII 1198
Score = 323 bits (829), Expect = 1e-87
Identities = 288/959 (30%), Positives = 427/959 (44%), Gaps = 79/959 (8%)
Query: 479 PEPLPEVAL-----PGSFVVRVTARDPDQGTNGQVTY---SLAPGAHTHWFSIDPTSGII 530
P P +VAL G+ ++++ A +G +V+Y L +F ID +G +
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305
Query: 531 TTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEG 590
+T + LD E + L V A D PP +++ ++V ++D ND+ P F+++ Y + E
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 591 TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGP 650
+ G L + A+D DS L Y + G F+++ SG V T LDR++
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV----FQLNESSGVVSTRAVLDREEA- 420
Query: 651 SSFDFTVTAVDGGG----LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLR 706
+ + V A D G L + V + + DENDN PQF + Y + TAVLR
Sbjct: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
Query: 707 LRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGG 766
++A D DQG + + Y IL+GN F L SG+L V PL L I A+DGG
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
Query: 767 GLQA-EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPG------ 819
S V + ++ PIF + +V E+V G V +QA +
Sbjct: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
Query: 820 --RLAPVTLSLSGGDPRGL----------FSLDAVSGLLQTLRPLDRELLGPVLELEVRA 867
RL + GG G F + SG + LDRE +
Sbjct: 601 HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660
Query: 868 GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNS 927
G PP + V + + DVNDN P F P + L + A G+ + TL+A D D+ NS
Sbjct: 661 DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NS 718
Query: 928 RVTFTLLAGGGG---AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRL 984
+T+ L G A + G + L PL + L + A DG + T+H +
Sbjct: 719 VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLI 777
Query: 985 RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGA 1041
V D T P F S Y V + GT + + A D G ITY + +
Sbjct: 778 NVT--DANTH--RPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI--QDP 831
Query: 1042 SSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101
F ++P SG ++ LD E Q Y L +MA + Q++ T T+ + IL+ N++
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG---IPQKSDTTTLEILILDANDN 888
Query: 1102 SPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTG 1161
+P+ D ++ E+ PP TS+ +V ATDRDSGPNGRL Y+ Q + F I P +G
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
Query: 1162 EVTTLQTLDREQQSSYQLLVQVQDGGSP-PRSTTGTVHVAVLDLNDNSPTFLQASGAAGG 1220
+ T + LDRE + Y L D GSP P S + + V +LD+NDN+P F +
Sbjct: 949 VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDE----- 1003
Query: 1221 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPL 1279
L + V + P G++V ++A DPDEG N I+Y + G F L +G+L L
Sbjct: 1004 -LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVEL 1062
Query: 1280 IRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL-- 1337
R YVL + A R+ LLV D + P P +L
Sbjct: 1063 DFEVRREYVLVVQATSAPLVSRATVHILLV-------------DQNDNPPVLPDFQILFN 1109
Query: 1338 -TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
VT P ++G + A +P +L YT V G + LD A+G L L+R LD
Sbjct: 1110 NYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELR-LLLLDPATGELQLSRDLD 1167
Score = 318 bits (815), Expect = 6e-86
Identities = 288/977 (29%), Positives = 431/977 (44%), Gaps = 74/977 (7%)
Query: 577 QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSG 636
+F Y +L E GT LQ+ A G +SY + FRID+ +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 637 DVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASI 694
V T LDR+ + V AVD + Y+ V + D ND+ P F EY +
Sbjct: 304 AVSTDSVLDRET-KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 695 SAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANS 754
G VL +RA D D + L Y +L G + +F L+E SG+++ L R +
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAA 421
Query: 755 VVQLEIGAEDGGGLQA--EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIV 812
QL + A D G +A V I + P F + YV VPEDV T+V V
Sbjct: 422 EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
Query: 813 QA-HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSG 870
QA G+ A + S+ G+ G F L ++SG+L + PLD E + L ++ + G
Sbjct: 482 QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541
Query: 871 VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930
P + V V + DVNDN P F + + N G P+ ++A+D DSG N+R+
Sbjct: 542 PPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
Query: 931 FTLL------AGGGGA------------FTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972
+ L+ GGG A F + ++G + + L + +EA D
Sbjct: 602 YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
Query: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031
GSPP +S + + V DV P F PTY + L G+ VL +QA+ D
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDND--PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSV 719
Query: 1032 ITYHLAAEGASSPFGLEPQ--SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTA 1089
ITY L + F L Q G + + LD + ++ Y+L V A G+++ TA
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSH------TA 773
Query: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149
V +++ + N H P ++V+E++P GTS+ + A D D+G N R+TY +Q +
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---D 830
Query: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSP 1209
FRI P +G + T+ LD E Q +Y L + QD G P +S T T+ + +LD NDN+P
Sbjct: 831 PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP 890
Query: 1210 TFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTG--PGSELFSLH 1267
FL + + PP T + + A D D G NG +LYT G G F +
Sbjct: 891 QFLWDFYQG------SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIE 944
Query: 1268 PHSGELLTAAPLIRAERPHYVLTLSAHDQGSP-PRSASLQLLVQVLPSARLAEPPPDLAE 1326
P SG + T L R Y L A D+GSP P SAS+++ V +L + + P + E
Sbjct: 945 PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD---INDNAP-MFE 1000
Query: 1327 RDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGTFALDAA 1384
+D L + E GS++ + A +P G A + Y +V G D F LD
Sbjct: 1001 KDE-------LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG-DMRHFFQLDLL 1052
Query: 1385 SGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLA-- 1442
+G L LDFE + + P + A V + + D+N++ P +
Sbjct: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRA---TVHILLVDQNDNPPVLPDFQILFN 1109
Query: 1443 --LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500
+ N P + A D P + + Y + Q + L LD TG L R
Sbjct: 1110 NYVTNKSNSFPTGVIGCIPAHD---PDVSDSLNYTFV-QGNELRLLLLDPATGELQLSRD 1165
Query: 1501 LDRETTPALLLLVEATD 1517
LD L+ V +D
Sbjct: 1166 LDNNRPLEALMEVSVSD 1182
Score = 308 bits (789), Expect = 6e-83
Identities = 247/860 (28%), Positives = 396/860 (46%), Gaps = 78/860 (9%)
Query: 2059 QGEAERGP-RFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITY---SILSGNEKG 2113
+G + RG +FP + + + EN P GT I+ A + G ++Y + +G
Sbjct: 235 RGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRG 294
Query: 2114 TFSIQPSTGAITVRSAEGLDFEVSPRLRL-VLQAESGGAFAFTVLTLTLQDANDNAPRFL 2172
F I +TGA++ S + + + LR+ + + A T +T+ ++D ND++P F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 2173 RPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTT 2232
+ Y + E+ + +L + A D D + Y + A +F ++ ++G ++T
Sbjct: 355 QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG--AWDVFQLNESSGVVSTR 412
Query: 2233 AILDREIWAETRLVLMATDRG-SPA-LVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDA 2289
A+LDRE AE +L++ A D+G +P L +AT+ + V D NDN P Q + ++V ED
Sbjct: 413 AVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDV 472
Query: 2290 LLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQL 2347
L + + +V D D G + Y + F + G + + PLDFE +Y L
Sbjct: 473 GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL 532
Query: 2348 QLLAHDGPHEGRAN----LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDR 2403
+ A DG N ++V V DVNDN P F S +Q +LE+ P G ++ + A D
Sbjct: 533 SIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDA 592
Query: 2404 DSGANGHISYHLASPADGF----SVDPNNGTL-----FTIVGTVALGHDGSGAVDVV--- 2451
DSG N + Y L A F S P N F I H+ SG + V
Sbjct: 593 DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI-------HNSSGWITVCAEL 645
Query: 2452 -----------LEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGST 2500
+EA DHG+P ++ +V + + D ND+ P FT Y + + ED GS+
Sbjct: 646 DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS 705
Query: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
+LTL+A D D +++ + Y + GN F L + R G + L PL
Sbjct: 706 VLTLQARDRD---ANSVITYQLTGGNTRNRFALSSQ------------RGGGLITLALPL 750
Query: 2561 DFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAE 2620
D++ QY L V A+D +S V + V D N + PVF + Y V+V ED PVG
Sbjct: 751 DYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
Query: 2621 LLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAA 2680
+ + A+D D G + + + + DP F +D SGT+ LD E Q + L + A
Sbjct: 808 IATLSANDEDTGENARITYVIQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
Query: 2681 DPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF 2738
D G T+E+ D ND+ P F + S+ E+ PP T + + A D D+G
Sbjct: 866 DN-GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 2739 GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN---LSA 2795
GRL Y+ G +G F + ++G +R + D E+ + L A D G+ LSA
Sbjct: 925 GRLLYTFQG---GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 2796 SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATS 2855
SV + V + ++ P+F V E G + ++A D D G + ++Y +
Sbjct: 982 SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
Query: 2856 S--PYFGINQTTGALYLRVD 2873
+F ++ G L V+
Sbjct: 1042 DMRHFFQLDLLNGDLRAMVE 1061
Score = 300 bits (769), Expect = 1e-80
Identities = 267/919 (29%), Positives = 406/919 (44%), Gaps = 60/919 (6%)
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + ++L+++A D +PPR A + V + D NDH+P F QS Y V E+L G
Sbjct: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVV 332
VL + ASD D+ +N + Y + F ++ +G++ LD E+ ++L+V
Sbjct: 371 EVLTIRASDRDSPINANLRYRV---LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427
Query: 333 QARDGGAHPELGSAFVTVH--VRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390
+A D G +P SA TV+ V D NDN P F + QV E V R+
Sbjct: 428 EANDQGRNPGPLSATATVYIEVEDENDNYPQ----FSEQNYVVQVPEDVGLNTAVLRVQA 483
Query: 391 SDPDDGDFAHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG 448
+D D G A ++ S+ G G F L + ++ ++ LD E+ Y+L + A D G
Sbjct: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVI---NPLDFEDVQKYSLSIKAQDGG 540
Query: 449 SPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507
PPL + V + V DVNDN P F ++ L V L G VV + A D D G N +
Sbjct: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVVHIQAVDADSGENAR 599
Query: 508 VTYSLAPGAHTHW-----------------FSIDPTSGIITTAASLDYELEPQPQLIVVA 550
+ Y L A T F I +SG IT A LD E V A
Sbjct: 600 LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEA 659
Query: 551 TDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPF 610
D G PP++SS +VS+ + DVNDN+P F + Y L E G+ L + A D D+
Sbjct: 660 VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN-- 717
Query: 611 GLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD-QGPSSFDFTVTAVDGGGLKSMV 669
+++Y L G + F + + G T L D + + VTA D G
Sbjct: 718 SVITYQL---TGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTA 773
Query: 670 YVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNS 729
+V + ++D N + P F Y S+S P GT++ L A+D D G + R++Y I +
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI--QDP 831
Query: 730 PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
P F +D SG + L L I A+D G Q + ++I I+ P
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
Query: 790 FEQLQYVFSVPEDVAPGTSVGIVQA----HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
F Y S+ ED P TS+ V A P GRL + G D G F ++ SG+
Sbjct: 892 FLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL--LYTFQGGDDGDGDFYIEPTSGV 949
Query: 846 LQTLRPLDRELLGPVLELEVRAGSGVP-PAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904
++T R LDRE + + G P P A ++V + D+NDN+P F E + +
Sbjct: 950 IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
Query: 905 PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963
N G+ + +RA DPD G N+++ + ++ G F +D G +R M L
Sbjct: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
Query: 964 HELELEARDGGSPPRTSHFRLRVVVQDVGTR-GLAPRFNSPTYRVDLPSGTTAGTQVLQ- 1021
+ L ++A S P S + +++ D + P F + T V+
Sbjct: 1070 YVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
Query: 1022 VQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080
+ A PD + Y L+P +G L + LD +++V G
Sbjct: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDG--- 1183
Query: 1081 ELGQQTGTATVRVSILNQN 1099
+ T T+RV+I+ +
Sbjct: 1184 -IHSVTAFCTLRVTIITDD 1201
Score = 297 bits (760), Expect = 1e-79
Identities = 245/795 (30%), Positives = 372/795 (46%), Gaps = 80/795 (10%)
Query: 2170 RFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA--SQPARGLFHVDPTTG 2227
+F P+Y L E+ P +LQ+ A +G ++SY + + +RG F +D TG
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 2228 TITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVS 2286
++T ++LDRE L + A D +P + +TV+V DTND+ P Q + RV
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCD 2343
E+ +G E+ + +D DS + + VL G D F + G VS LD E+
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLG--GAWDVFQLNESSGVVSTRAVLDREEAA 421
Query: 2344 RYQLQLLAHD-----GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398
YQL + A+D GP A + + VED NDN P FS+ Y V + E +A+L V
Sbjct: 422 EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
Query: 2399 SATDRDSGANGHISYHLASP--ADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
ATDRD G N I Y + S A F + +G L I L + + ++A+D
Sbjct: 482 QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN---PLDFEDVQKYSLSIKAQD 538
Query: 2457 HGAPGRA-ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSH 2515
G P + V VQ+ D ND+ P F S ++ V E++P G ++ ++A DAD S +
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD-SGEN 597
Query: 2516 AAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA------------LGCLVLLEPLDFE 2563
A + Y ++ G SAGP A G + + LD E
Sbjct: 598 ARLHYRLVD---------TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648
Query: 2564 SLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623
+ Y+ V A D G PP SS V++TVLDVNDN PVFT+ +Y + + ED VG+ +L
Sbjct: 649 EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
Query: 2624 VEASDADPGPHGLVRFTVSSGDPSGLFELDES--SGTLRLAHALDCETQARHQLVVQAAD 2681
++A D D + ++ + ++ G+ F L G + LA LD + + ++ L V A+D
Sbjct: 709 LQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Query: 2682 PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRL 2741
+H A V I V D N H P F + + SV+E++P GT + TL A D D G R+
Sbjct: 767 GTRSH--TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARI 824
Query: 2742 RYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTV 2799
Y + + P F ++ +G + + DYE+ ++ L + A D G S + T+
Sbjct: 825 TYVIQDPVP------QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878
Query: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYF 2859
+L+ ++ P FL + + E A S+ V ATD D G +G +LY+ +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT------FQ 932
Query: 2860 GINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRE-------LRLEVIARGPLPGSR 2912
G + G Y+ P SG RT+R RE L V P P S
Sbjct: 933 GGDDGDGDFYIE-----PTSGVI------RTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 2913 SATVPVTV-DITHTA 2926
S + VT+ DI A
Sbjct: 982 SVEIQVTILDINDNA 996
>gi|216548395 dachsous 2 isoform 3 [Homo sapiens]
Length = 709
Score = 398 bits (1022), Expect = e-110
Identities = 257/641 (40%), Positives = 351/641 (54%), Gaps = 67/641 (10%)
Query: 25 LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQE 84
LL LL+ + G+ Q +L L +DE P TL+GDI AGLPA F +++
Sbjct: 47 LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
Query: 85 G--SGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPA 142
S + D + +G++RTAR LDRE+RD Y F A T GA V+V +RV D+NDH+P
Sbjct: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPR 166
Query: 143 FPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL------SGDGAGETFRLETR 196
FP L V E + GT + L A D DAG TQGY L D AG F+L R
Sbjct: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
Query: 197 -PGPDGTPVP----------ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTL 245
PGP +P+ +LV+ LDRE + + LQ+EA+DGG P R +++ +
Sbjct: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
Query: 246 LDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP- 304
LD ND+ P F Q Y A V E PG+ V +V A+D D G NG V Y + RQ G G
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
Query: 305 ---------FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355
F+++ +G++++ RPLD E + H+LVV+ARDGGA PE+ + V++ V D
Sbjct: 347 GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
Query: 356 NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF----------------A 399
NDN+P++ V+FL+ G +VSE A PG VAR+SVSD DGD+
Sbjct: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDA-DGDWEKEDEATGELGVGLGDG 465
Query: 400 HVNVSLEGGEGHFALSTQDSV-IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF 458
+++SLEGGEG FAL ++ +CV LDRE RD Y L + ATD+GSPPL E
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
Query: 459 VLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ------VTYSL 512
+L V D+ND P F +Q Y+ + E A PG+ V+ V+A D D+ + V
Sbjct: 526 LLRVADLNDQPPLFSQQHYKAS-VSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
Query: 513 AP---------GAHT----HWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559
AP HT F+ID SG I+T +LD E++ +L VVA D G PPL+
Sbjct: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
Query: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV 600
++ VS+ + DVNDNEP F R YNA++ E G CFLQ+
Sbjct: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 215 bits (548), Expect = 5e-55
Identities = 197/627 (31%), Positives = 272/627 (43%), Gaps = 96/627 (15%)
Query: 1337 LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALD-----AASGRLYLA 1391
LT++ EGL P +L+G + A PA D + + LD +G + A
Sbjct: 69 LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
Query: 1392 RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEP 1451
R LD E + + G +++V+++V D N+H+P F D L L + E P
Sbjct: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
Query: 1452 GAALYTFRASDADGPGPNSDVRYRLLR-----QEPPVPALRLDART-GALSAP------- 1498
G A A D D G S Y L++ ++P P +L RT G L +P
Sbjct: 183 GTAFRLPVAHDPDA-GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
Query: 1499 ----------RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS 1548
R LDRE A L +EA D RR +S + V DENDN PVF
Sbjct: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWD---GGRPRRTGLLSVELRVLDENDNPPVFEQ 298
Query: 1549 PS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL-------------ASGGDGHFRL 1594
R + ED PG V A D DLG V Y + A G +F +
Sbjct: 299 DEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAV 358
Query: 1595 HSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT----FQ 1650
+G + V RPLDRE +A H L V A D G+ P AT ++++V DVND P F
Sbjct: 359 EELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418
Query: 1651 QQEYSVLLRENNPPGTSLLTLRATDPDVG------ANGQVTYG-GVSSESFSLDPDTGVL 1703
+ + E PG + + +D D A G++ G G S S SL+ G
Sbjct: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
Query: 1704 TTLRA-------------LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
L LDRE ++ L + A D GSPP T T+ + V D ND P
Sbjct: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
Query: 1751 FGSAHLSLEVPEGQDPQTLTM-LRASDPDVGAN------------------GQLQYRILD 1791
F H V E P T+ M + ASD D + G LQ +++
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
Query: 1792 GDPSG-AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDAND 1850
G +F +D SG T+R LDREV+ A +L++ A+D G+P LSAT L+++TV D ND
Sbjct: 599 TAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658
Query: 1851 HAPAFPVPAYSVEVPEDVPAGTLLLQL 1877
+ P F Y+ + E P G LQL
Sbjct: 659 NEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 183 bits (465), Expect = 2e-45
Identities = 169/554 (30%), Positives = 231/554 (41%), Gaps = 97/554 (17%)
Query: 1492 TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS- 1550
TG + R LDRE + A+ A V + V D ND++P F S
Sbjct: 122 TGIIRTARRLDRERRDHYSFV---------AATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
Query: 1551 RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-------GHFRLHSSTGA--- 1600
++ + E PPG A VA DPD G + Y L D F+L T
Sbjct: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
Query: 1601 ---------------LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDE 1645
L ++R LDRE+ A H L + A D G P R+ + + V D ND
Sbjct: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 1646 APTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY-------------GGVSSE 1692
P F+Q EY +RE+ PG + +RATD D+G NG V Y GG +
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
Query: 1693 S--FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
+ F+++ +GV+ R LDRE Q L V A+D G+ P++ V V +AV D ND+ P
Sbjct: 353 AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
Query: 1751 FGSAHLS----LEVPEGQDP-QTLTMLRASDPDVG------ANGQLQYRILDGDPSGAFV 1799
L+ V EG P + + SD D A G+L + GD S +
Sbjct: 413 IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL--GDGSISLS 470
Query: 1800 LDLASGEFGTMR-------------PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVL 1846
L+ G+F + PLDRE ++L + A D G P LS L + V
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH-----------VTYYLG 1895
D ND P F Y V E GT+++ + A D D + H LG
Sbjct: 531 DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
Query: 1896 ---------AGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSV 1946
A +F ++ SG + T LDRE + V A D PLS T V
Sbjct: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD-LGEPPLSATCLV 649
Query: 1947 TITVRDVNDHAPTF 1960
+ITV DVND+ P F
Sbjct: 650 SITVDDVNDNEPIF 663
Score = 182 bits (463), Expect = 4e-45
Identities = 171/567 (30%), Positives = 239/567 (42%), Gaps = 84/567 (14%)
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE R HY G A +++ + D+NDH+P F VSE PG+
Sbjct: 131 LDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQS---EGDGPF-------------------SIDAH 310
A D DAG+ Y + + + GPF S
Sbjct: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
Query: 311 TGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSAD 370
L L R LD E+ H L ++A DGG G V + V D NDN P +F +
Sbjct: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP----VFEQDE 300
Query: 371 GSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLE-----------GGEGHFALSTQDS 419
V E A PG V R+ +D D G V S+ G G A +
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
Query: 420 VIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRP 479
+ +V V R LDRE + + L V A D G+ P A + V DVNDN PA L+
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLT 419
Query: 480 EP----LPEVALPGSFVVRVTARDPD-------QGT--------NGQVTYSLAPGAHTHW 520
E + E A PG +V RV+ D D + T +G ++ SL G
Sbjct: 420 EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
Query: 521 FSIDPTSGI--ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQF 578
G+ + LD E +L++VATD G PPL++ T+ + + D+ND P F
Sbjct: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
Query: 579 QRTFYNASLPEGTQPGTCFLQVTATDADSG-------PFGLLSYSLGAGLGSSGS----- 626
+ Y AS+ E PGT + V+A+DAD + ++ S LGS S
Sbjct: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
Query: 627 ----PPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDEND 680
P F ID+ SG + T RTLDR+ + + V A D G L + V + + D ND
Sbjct: 600 AECGPSFAIDSESGAISTIRTLDREV-QEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658
Query: 681 NPPQFYPREYAASISAQSPPGTAVLRL 707
N P F+ + Y A+I+ +P G L+L
Sbjct: 659 NEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 173 bits (438), Expect = 3e-42
Identities = 198/688 (28%), Positives = 276/688 (40%), Gaps = 103/688 (14%)
Query: 2106 ILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDAN 2165
+L G S+GA T RS L + + L A SG + LTL++ +
Sbjct: 24 LLPGRRDTPHGRSGSSGARTQRSLLWL------LVHVWLWAASGSSAQLFNLTLSVDEGL 77
Query: 2166 DNAPRFLRPHYVAFLPESRPLEGP--LLQVEADDLDQGSGGQISYSLAASQPARGLFHVD 2223
P L A LP ++ EG L ++DD P FHV
Sbjct: 78 P--PDTLVGDIRAGLPAAQQQEGSGFFLSEDSDD----------------SPLLDDFHVH 119
Query: 2224 PTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSAT-LTVMVIDTNDNRPTIP-QPW 2281
P TG I T LDRE V + L+G+ + + V D ND+ P P
Sbjct: 120 PDTGIIRTARRLDRERRDHYSFV-------AATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
Query: 2282 ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLS-----PSGPQDPFSVGRYGGRVSLT 2334
+L VSE + G+ +D D+G Y L P P PF RY L
Sbjct: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
Query: 2335 GPL-------------------DFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDN 2372
PL D E+ ++LQ+ A DG R L + V D NDN
Sbjct: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 2373 APAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL-------ASPADGFSVD 2425
P F Q Y+ + E PG+ + V ATDRD G NG + Y + A G D
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
Query: 2426 PNNGTLFTIVGTVA----LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPS 2481
+ + G V L + +V+EARD GA A V + + D ND+ P+
Sbjct: 353 AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
Query: 2482 FT---LSHYRVA-VTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLE 2534
L+ VA V+E PG + + +DADG A + + G+ LE
Sbjct: 413 IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
Query: 2535 PRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLD 2594
+ G GP + L + PLD ES Y L + A D G PP S+ + + V D
Sbjct: 473 GGEGDFALLPG-GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
Query: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG--PHGLVRFTVSS-GDPSGL-- 2649
+ND PP+F++ Y+ +V E G ++ V ASDAD H +R+TV P L
Sbjct: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
Query: 2650 --------------FELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTI 2694
F +D SG + LD E Q +L V A D A V+I
Sbjct: 592 LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
Query: 2695 EVQDVNDHGPAFPLNLLSTSVAENQPPG 2722
V DVND+ P F + + ++AE+ P G
Sbjct: 652 TVDDVNDNEPIFWRQVYNATIAEHAPVG 679
Score = 164 bits (416), Expect = 1e-39
Identities = 192/658 (29%), Positives = 272/658 (41%), Gaps = 133/658 (20%)
Query: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682
D G PP + V D+ P QQQE S + + LL
Sbjct: 74 DEGLPPDTL-------VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL------------- 113
Query: 1683 QVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742
+ F + PDTG++ T R LDRE ++ + V A G+ Q V + V
Sbjct: 114 ---------DDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVN 158
Query: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLR-ASDPDVGANGQLQYRI-----LDGDPSG 1796
D NDH+P F L L+V E P T L A DPD G Y + L DP+G
Sbjct: 159 DVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
Query: 1797 AFVL-----------DLASGEFGTMRPLD--------REVEPAFQLRIEARDGGQPALSA 1837
F L G + PLD RE A +L+IEA DGG+P +
Sbjct: 219 PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG 278
Query: 1838 TLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--- 1894
L + + VLD ND+ P F Y V ED G + +++A D D G NG V Y +
Sbjct: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
Query: 1895 ---GAGTAGA-------FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV 1944
GAG+ G F +E SG +R LDRE + V A DG A P TV
Sbjct: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATV 397
Query: 1945 SVTITVRDVNDHAPT----FPTSPLRLRL---PRPGPSFSTPTLALA--TLRAEDRDAG- 1994
V+I V DVND+ P F T R+ RPG + +++ A ED G
Sbjct: 398 RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
Query: 1995 -----ANASILYRLAGTP---------PPGTTVDSYTGEIRVARSPVALGPRDRV-LFIV 2039
+ SI L G PPG G P+ RD L +V
Sbjct: 458 LGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEG-------PLDRESRDLYELLLV 510
Query: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV---SPRAVHAG 2096
ATD G P S +++ + ++ P F + +A++ E A PGT ++ + A AG
Sbjct: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
Query: 2097 GTNGPITYSILS-------GNEKG----------TFSIQPSTGAI-TVRSAEGLDFEVSP 2138
+ + Y+++ G+ + +F+I +GAI T+R+ LD EV
Sbjct: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
Query: 2139 RLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQV 2193
+ L + A+ G A ++++T+ D NDN P F R Y A + E P+ LQ+
Sbjct: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 163 bits (412), Expect = 3e-39
Identities = 167/562 (29%), Positives = 243/562 (43%), Gaps = 81/562 (14%)
Query: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH----GAPGRAARATVHVQLQDQ 2475
D F V P+ G + T A + E RDH A A V +++ D
Sbjct: 114 DDFHVHPDTGIIRT-------------ARRLDRERRDHYSFVAATLLGAVVQVEIRVNDV 160
Query: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN------WGR 2529
NDH+P F L ++ V+E PPG+ A D D + Y+++ + G
Sbjct: 161 NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGL-FSTQGYTLVQPSDLPKDPAGP 219
Query: 2530 VFQLEPRLAEAGESAGPGPRAL--GC--------LVLLEPLDFESLTQYNLTVAAADRGQ 2579
FQL R + GP P L G LVLL LD E + L + A D G+
Sbjct: 220 FFQLRYR------TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
Query: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639
P ++ ++ V + VLD NDNPPVF + YR V ED GAE+ V A+D D GP+G VR+
Sbjct: 274 PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
Query: 2640 TVSSGDPSG------------LFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAH 2686
+V + G F ++E SG +R+ LD E QA HQLVV+A D A
Sbjct: 334 SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
Query: 2687 FALAPVTIEVQDVNDHGPAFPLNLLS----TSVAENQPPGTLVTTLHAIDGDAGAFGRLR 2742
A V+I V DVND+ PA + L+ V+E PG V + D D G + +
Sbjct: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD-GDWEKED 452
Query: 2743 YSLLEAGPG-PEGREAFALNSSTGE-------------LRARVPFDYEHTESFRLLVGAA 2788
+ E G G +G + +L G+ L P D E + + LL+ A
Sbjct: 453 EATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT 512
Query: 2789 DAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDED--GGA 2844
DAG+ LS T+ + V ++ P+F + V E A G + V A+D D G
Sbjct: 513 DAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSD 572
Query: 2845 DGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTR---REAPRELRLE 2901
+ Y++ S + + + + + SG R RE + L+
Sbjct: 573 HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632
Query: 2902 VIAR--GPLPGSRSATVPVTVD 2921
V+A+ G P S + V +TVD
Sbjct: 633 VVAQDLGEPPLSATCLVSITVD 654
Score = 152 bits (384), Expect = 5e-36
Identities = 161/587 (27%), Positives = 230/587 (39%), Gaps = 122/587 (20%)
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEAT 2076
TG IR AR + RD F+ AT LG A + + + + PRFP S +
Sbjct: 122 TGIIRTARR-LDRERRDHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLD 175
Query: 2077 IRENAPPGTPIVSPRAVHAGG------------------------------TNGPITYSI 2106
+ E +PPGT P A T GP+ +
Sbjct: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
Query: 2107 LSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLT---LTLQD 2163
L G+ ++P + R LD E + RL ++A GG T L L + D
Sbjct: 236 LPGSSS---PLEPLDLVLLRR----LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
Query: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQ-PARG---- 2218
NDN P F + Y A + E + +V A D D G G + YS+ A Q P G
Sbjct: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
Query: 2219 ------LFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
F V+ +G + LDRE A +LV+ A D G+ V + +++ V+D ND
Sbjct: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
Query: 2273 NRPTI-----PQPWELRVSEDALLGSEIAQVTGNDVDS---------------------- 2305
NRP I + RVSE A G +A+V+ +D D
Sbjct: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
Query: 2306 ----GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358
G + L P GP F + + GPLD E D Y+L L+A D P
Sbjct: 469 LSLEGGEGDFALLPGGPPGVFFL-------CVEGPLDRESRDLYELLLVATDAGSPPLST 521
Query: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHI------- 2411
L + V D+ND P FSQ Y+ + E PG+ ++ VSA+D D + H
Sbjct: 522 EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
Query: 2412 --------------SYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457
H A F++D +G + TI L + AV++ + A+D
Sbjct: 582 QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR---TLDREVQEAVELKVVAQDL 638
Query: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504
G P +A V + + D ND+ P F Y + E P G L L
Sbjct: 639 GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 151 bits (382), Expect = 9e-36
Identities = 174/606 (28%), Positives = 250/606 (41%), Gaps = 101/606 (16%)
Query: 693 SISAQSPPGTAVLRLRAHDP----DQGSHGRLSYHILAGNSPPL--FTLDEQSGLLTVAW 746
S+ PP T V +RA P +GS LS + +SP L F + +G++ A
Sbjct: 72 SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED--SDDSPLLDDFHVHPDTGIIRTAR 129
Query: 747 PLARRAN------------SVVQLEIGAEDGGGLQAE---PSARVDISIV--PGT----- 784
L R +VVQ+EI D S ++D+S + PGT
Sbjct: 130 RLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLP 189
Query: 785 ----PTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSL 839
P +F Y P D+ + Q + PG P+ L G L L
Sbjct: 190 VAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG---PLPSPLLPGSSSPLEPL 246
Query: 840 DAVSGLLQTLRPLDRE-LLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE 898
D V LR LDRE L++E G G P + V + + D NDN P F E
Sbjct: 247 DLV-----LLRRLDREEAAAHRLQIEAWDG-GRPRRTGLLSVELRVLDENDNPPVFEQDE 300
Query: 899 DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA-------GGGGA------FTVDP 945
+ + PG + +RA D D G N V +++ A GGGA F V+
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
Query: 946 TTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPR--FNSP 1003
+G VR+ RPL H+L +EARDGG+ P + R+ + V DV A F +
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
Query: 1004 TYRVDLPSGTTAGTQVLQVQAQAPDG----------------GPITYHLAAEGASSPFGL 1047
+ G G V +V DG G + L+ EG F L
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
Query: 1048 EPQSG----WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSP 1103
P +L V LDRE+++LY L ++A L + T+ + + + N+ P
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE---TLLLRVADLNDQPP 537
Query: 1104 RLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGR--LTYSLQQLS------------- 1148
S+ +V+E PGT V V A+D D + L Y++ QLS
Sbjct: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
Query: 1149 ---EDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLN 1205
E +F I ++G ++T++TLDRE Q + +L V QD G PP S T V + V D+N
Sbjct: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
Query: 1206 DNSPTF 1211
DN P F
Sbjct: 658 DNEPIF 663
Score = 149 bits (377), Expect = 3e-35
Identities = 177/631 (28%), Positives = 262/631 (41%), Gaps = 108/631 (17%)
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLE-----PSSGELRTAA 1915
++ V E +P TL+ ++A P A ++L + + LL+ P +G +RTA
Sbjct: 70 TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
Query: 1916 ALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL---RLPRP 1972
LDRE+ Y+F AA L V V I V DVNDH+P FP L+L L P
Sbjct: 130 RLDRERRDHYSF-------VAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
Query: 1973 GPSFSTP-----------TLALATLRAEDRD---AGANASILYRLAGTPP----PGTTVD 2014
G +F P T ++ D AG + YR G P PG++
Sbjct: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
Query: 2015 SYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQ--GEAERGPRFPRAS 2072
++ + R L I A D GRP R TG++ V L+ E + P F +
Sbjct: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRR--TGLLSVELRVLDENDNPPVFEQDE 300
Query: 2073 SEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGT------------FSIQP 2119
A +RE+A PG + RA G NG + YS+ + G F+++
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
Query: 2120 STGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHY 2176
+G VR LD E +LV++A GGA A +++ + D NDN P +
Sbjct: 361 LSGV--VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI----H 414
Query: 2177 VAFLPE---SRPLEGP-----LLQVEADDLD-------QGSG--------GQISYSLAAS 2213
V FL E +R EG + +V D D + +G G IS SL
Sbjct: 415 VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
Query: 2214 QPARGLFHVDPT-TGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
+ L P + LDRE L+L+ATD GSP L TL + V D ND
Sbjct: 475 EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
Query: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGP-----VLWYVLSPSGPQD------ 2320
P Q ++ VSE A G+ + V+ +D D + + V+ S P +
Sbjct: 535 QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
Query: 2321 ----------PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPHEGRANLTVLVE 2367
F++ G +S LD E + +L+++A D P +++ V+
Sbjct: 595 KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
Query: 2368 DVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398
DVNDN P F + +Y + EH P G L +
Sbjct: 655 DVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
Score = 149 bits (375), Expect = 6e-35
Identities = 170/665 (25%), Positives = 251/665 (37%), Gaps = 107/665 (16%)
Query: 447 SGSPPLRAEAAFVLHV---TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQG 503
SG+ R+ ++HV +A F+ L E LP L G + A +G
Sbjct: 39 SGARTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEG 98
Query: 504 TNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSAT 563
+ ++ F + P +GII TA LD E + G +
Sbjct: 99 SGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV------VQ 152
Query: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG--------------- 608
V + + DVND+ P+F + E + PGT F A D D+G
Sbjct: 153 VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDL 212
Query: 609 ------PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDG 662
PF L Y L S P D+ R LDR++ ++ + A DG
Sbjct: 213 PKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEA-AAHRLQIEAWDG 271
Query: 663 GGLK--SMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRL 720
G + ++ V++ + DENDNPP F EY A++ + PG V R+RA D D G +G +
Sbjct: 272 GRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFV 331
Query: 721 SYHILAGNSP------------PLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGL 768
Y + A P F ++E SG++ V PL R A + QL + A DGG
Sbjct: 332 RYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE 391
Query: 769 QAEPSARVDISIVPGTPTPPIFEQLQY----VFSVPEDVAPGTSVGIVQAHNPPGRL--- 821
+ RV I+++ P L V V E PG V V + G
Sbjct: 392 PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
Query: 822 -------------APVTLSLSGGD---------PRGLFSLDAVSGLLQTLRPLDRELLGP 859
++LSL GG+ P G+F L V G PLDRE
Sbjct: 452 DEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFL-CVEG------PLDRESRDL 504
Query: 860 VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRAL 919
L V +G PP + + + D+ND P F + APGT + + A
Sbjct: 505 YELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSAS 564
Query: 920 DPD----------------------SGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLG 957
D D + S++ T A G +F +D +G + +R L
Sbjct: 565 DADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT--AECGPSFAIDSESGAISTIRTLD 622
Query: 958 PSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGT 1017
A EL++ A+D G PP ++ + + V DV P F Y + G
Sbjct: 623 REVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDN--EPIFWRQVYNATIAEHAPVGH 680
Query: 1018 QVLQV 1022
LQ+
Sbjct: 681 CFLQL 685
Score = 144 bits (363), Expect = 1e-33
Identities = 161/597 (26%), Positives = 235/597 (39%), Gaps = 90/597 (15%)
Query: 2302 DVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN 2361
D D P+L D F V G + LD E+ D Y G
Sbjct: 106 DSDDSPLL----------DDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG---AVVQ 152
Query: 2362 LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG 2421
+ + V DVND++P F Q+ + E +PPG+A A D D+G Y L P+D
Sbjct: 153 VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSD- 211
Query: 2422 FSVDPNN----------GTL--------------FTIVGTVALGHDGSGAVDVVLEARDH 2457
DP G L +V L + + A + +EA D
Sbjct: 212 LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDG 271
Query: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA 2517
G P R +V +++ D+ND+ P F YR AV ED PG+ + + ATD D +
Sbjct: 272 GRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLG-PNGF 330
Query: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGP-----RALGCLVLLEPLDFESLTQYNLTV 2572
V YS+ R Q+ P G + G G + + PLD E+ + L V
Sbjct: 331 VRYSV------RARQV-PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVV 383
Query: 2573 AAADRGQPPQSSVVPVTVTVLDVNDNPP----VFTRASYRVTVPEDTPVGAELLHVEASD 2628
A D G P+ + V V++ VLDVNDN P +F V E G + V SD
Sbjct: 384 EARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSD 443
Query: 2629 ADPG----PHGLVRFTVSSGDPSGLFELDESSGTLRLAHA-------------LDCETQA 2671
AD V GD S L+ G L LD E++
Sbjct: 444 ADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRD 503
Query: 2672 RHQLVVQAADPAGAHFALAP-VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHA 2730
++L++ A D + + + V D+ND P F SV+E PGT+V + A
Sbjct: 504 LYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSA 563
Query: 2731 IDGDAGAFGR--LRYSLLEAGPG-------------PEGREAFALNSSTGELRARVPFDY 2775
D D LRY++++ E +FA++S +G + D
Sbjct: 564 SDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDR 623
Query: 2776 EHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830
E E+ L V A D G LSA+ VS+ V ++ +P+F ++ + E A GH
Sbjct: 624 EVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGH 680
Score = 141 bits (356), Expect = 9e-33
Identities = 170/617 (27%), Positives = 246/617 (39%), Gaps = 138/617 (22%)
Query: 798 SVPEDVAPGTSVGIVQAHNPPGRLAPVT---LSLSGGDPRGL--FSLDAVSGLLQTLRPL 852
SV E + P T VG ++A P + + LS D L F + +G+++T R L
Sbjct: 72 SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRL 131
Query: 853 DRE-----------LLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTV 901
DRE LLG V+++E+R ++DVND+SP FP +
Sbjct: 132 DRERRDHYSFVAATLLGAVVQVEIR-----------------VNDVNDHSPRFPLDSLQL 174
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG------------------------ 937
+ + PGT A DPD+G+ S +TL+
Sbjct: 175 DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
Query: 938 ---GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTR 994
G + ++P + L+R L AH L++EA DGG P RT + + V D
Sbjct: 235 LLPGSSSPLEPLD--LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 995 GLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAE------------ 1039
P F YR + G +V +V+A D GP + Y + A
Sbjct: 293 --PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
Query: 1040 GASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI--LN 1097
G ++ F +E SG + V LDREAQ + L V A G G + ATVRVSI L+
Sbjct: 351 GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG-----GAEPEVATVRVSIAVLD 405
Query: 1098 QNEHSPRLS----EDPTFLAVAENQPPGTSVGRVFATDRDSG------PNGRLTYSLQQL 1147
N++ P + + V+E PG V RV +D D G L L
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL--- 462
Query: 1148 SEDSKAFRIHPQTGEVTTLQ-------------TLDREQQSSYQLLVQVQDGGSPPRSTT 1194
+ S + + G+ L LDRE + Y+LL+ D GSPP ST
Sbjct: 463 GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDE--GENGTI 1252
T+ + V DLND P F Q A V + PGT+V + A D DE ++ +
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKA------SVSEAAAPGTVVMWVSASDADEAGSDHAWL 576
Query: 1253 LYTL------------------TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAH 1294
YT+ T F++ SG + T L R + L + A
Sbjct: 577 RYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ 636
Query: 1295 DQGSPPRSASLQLLVQV 1311
D G PP SA+ + + V
Sbjct: 637 DLGEPPLSATCLVSITV 653
Score = 69.3 bits (168), Expect = 6e-11
Identities = 58/199 (29%), Positives = 84/199 (42%), Gaps = 32/199 (16%)
Query: 107 LDREQRDRYRFTAVTPDGATVEVT------VRVADINDHAPAFPQARAALQVPEHTAFGT 160
LDRE RD Y V D + ++ +RVAD+ND P F Q V E A GT
Sbjct: 497 LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556
Query: 161 RYPLEPARDADAG------------------RLGT-QGYALSGDGAGETFRLETRPGPDG 201
A DAD LG+ Q + G +F +++ G
Sbjct: 557 VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIS 616
Query: 202 TPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYH 261
T LDRE + L++ A D G PP A L+ +T+ D+ND+ P F + Y+
Sbjct: 617 T-------IRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYN 669
Query: 262 AVVSESLAPGSPVLQVFAS 280
A ++E G LQ+ ++
Sbjct: 670 ATIAEHAPVGHCFLQLISA 688
Score = 32.3 bits (72), Expect = 8.0
Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 4/154 (2%)
Query: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762
G + L L+ SV E PP TLV + A A + L E + F ++
Sbjct: 61 GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
Query: 2763 STGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQV 2822
TG +R D E + + + A L A V V + V +++ P F + V
Sbjct: 121 DTGIIRTARRLDRERRDHYSFVA----ATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
Query: 2823 PEGARRGHSLGHVQATDEDGGADGLVLYSLATSS 2856
E + G + A D D G Y+L S
Sbjct: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 348 bits (894), Expect = 4e-95
Identities = 264/784 (33%), Positives = 379/784 (48%), Gaps = 47/784 (5%)
Query: 16 SPRP---HLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISA--GLP- 69
SP P LLLP +LL LLLL A PG A + ++ EEQP TLIG ++A G P
Sbjct: 29 SPGPGGQRLLLPSMLLALLLLLAPSPG---HATRVVYKVPEEQPPNTLIGSLAADYGFPD 85
Query: 70 ------AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ---RDRYRFTAV 120
AP + + + G T+ +ID G+ L + T +
Sbjct: 86 VGHLYKLEVGAPYLR-VDGKTGDIFTTETSIDRE-GLRECQNQLPGDPCILEFEVSITDL 143
Query: 121 TPDGAT--VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQ 178
+G+ +E + V DIND+ P F L +PE+T G+ +P+ A D DAG G
Sbjct: 144 VQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
Query: 179 GYAL-SGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRA 237
Y L +G A E F L+ + P+L+V G LDRE Y L ++ DGGSPPR +
Sbjct: 204 SYELQAGPEAQELFGLQVAEDQEEKQ-PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
Query: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297
ALL VT+LD ND+AP F + Y A +SE+ G V+QV A+D+D G N + Y ++
Sbjct: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
Query: 298 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357
+D +TGL+ ++ P+D E V A+D G +P+ A V V V+D ND
Sbjct: 323 PEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
Query: 358 NQPSMTV----IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFA 413
N P++ + + DG +SE VA + VSD D+G+ A V + G+ F
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQ 441
Query: 414 L------STQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467
L + Y + LD E+ Y + + A DSG+PPL + + + V DVND
Sbjct: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
Query: 468 NAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP-GAHTHWFSIDPT 526
NAP F Q PE PG + +TA D D G+N ++ YSL P A F+I P
Sbjct: 502 NAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560
Query: 527 SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 586
+G I SLD E +L VVA D G P L +ATV V + D NDN+P+F + YN S
Sbjct: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 587 LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDR 646
+ E + VT D D G + S+ G F I +G + ++ + DR
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTILSSLSFDR 675
Query: 647 DQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFYPREYAAS--ISAQSPPGT 702
+Q S++ F + AVDGG YV V ++ DENDN P + ++ Q+ G
Sbjct: 676 EQ-QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734
Query: 703 AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGA 762
V ++ A D D G + L Y I GN LF + SG +T+ + RR + + +L +
Sbjct: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 763 EDGG 766
D G
Sbjct: 795 SDRG 798
Score = 255 bits (651), Expect = 6e-67
Identities = 274/1033 (26%), Positives = 420/1033 (40%), Gaps = 118/1033 (11%)
Query: 1543 APVFASPSRVRLPEDQPPGPAALHVVARD---PDLGEAARVSYRLASGGDGHFRLHSSTG 1599
+P A+ ++PE+QPP + +A D PD+G Y+L G + R+ TG
Sbjct: 53 SPGHATRVVYKVPEEQPPN-TLIGSLAADYGFPDVGHL----YKLEVGAP-YLRVDGKTG 106
Query: 1600 ALSVVRP-LDREQRAE--------------HVLTVVASDHGSPPRSATQVLTVSVADVND 1644
+ +DRE E V +GSP Q+ V D+ND
Sbjct: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI---EVQDIND 163
Query: 1645 EAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY----GGVSSESFSL---- 1696
P F ++ + EN G+ A+D D G NG +Y G + E F L
Sbjct: 164 NTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAE 223
Query: 1697 --DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754
+ L + LDRE + +LT+ QD GSPP+ + +RV V D ND+AP F
Sbjct: 224 DQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERP 283
Query: 1755 HLSLEVPEGQD-PQTLTMLRASDPDVGANGQLQYRILDGDP--SGAFVLDLASGEFGTMR 1811
E+ E ++ ++A+D D GAN +++Y LD +G
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 1812 PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV--------E 1863
P+DRE + + A+D G SA + VTV D ND+AP + +
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE-------LRTAAA 1916
+ EDV T + +Q D D G N VT + +G L+T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463
Query: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976
LD E+ YT + AVD PLS+T S+ + V DVND+AP F S + P
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN---- 518
Query: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDR 2034
+ P +A + A D D+G+NA ++Y L P T+ TGEI+V S
Sbjct: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
Query: 2035 VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVH 2094
L +VA D G P+ T ++V + + P+F + ++ EN P +P+ +
Sbjct: 579 ELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID 638
Query: 2095 AG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA-- 2151
G N + S+ N G F IQ TG T+ S+ D E L+A GG
Sbjct: 639 GDKGENAQVQLSVEQDN--GDFVIQNGTG--TILSSLSFDREQQSTYTFQLKAVDGGVPP 694
Query: 2152 -FAFTVLTLTLQDANDNAPRFLRPHYVA---FLPESRPLEGPLLQVEADDLDQGSGGQIS 2207
A+ +T+ + D NDNAP P + P++R L + QV A+D D G ++
Sbjct: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELI 753
Query: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267
YS+A P GLF + +G IT ++R RLV+ +DRG P G+A + + V
Sbjct: 754 YSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Query: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRY 2327
+T NR + + LLG + D+ P S + G
Sbjct: 813 NETLANRTLL----------ETLLGHSLDTPLDIDIAGDP----EYERSKQRGNILFGVV 858
Query: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387
G V++ + RY Q A G G+ +D+ P+ S +
Sbjct: 859 AGVVAVALLIALAVLVRYCRQREAKSGYQAGKKE----TKDLYAPKPSGKASKGNKSKGK 914
Query: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447
+ + V D ++G + ++L S A G S + + L +
Sbjct: 915 KSKSPKPVKPVEDED-EAGLQKSLKFNLMSDAPGDSPRIH----------LPLNYPPG-- 961
Query: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
+ D G R+ +QLQ Q +PS + H V +DLPP +T + T
Sbjct: 962 ------SPDLGRHYRSNSPLPSIQLQPQ---SPSASKKH---QVVQDLPPANTFVGTGDT 1009
Query: 2508 DADGSRSHAAVDY 2520
+ GS ++ Y
Sbjct: 1010 TSTGSEQYSDYSY 1022
Score = 253 bits (645), Expect = 3e-66
Identities = 234/785 (29%), Positives = 347/785 (44%), Gaps = 84/785 (10%)
Query: 1399 GPPWRALTVRAEGPGGAG----ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAA 1454
GPP + GPGG + LL + + + HA + +PE P
Sbjct: 19 GPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATR-----VVYKVPEEQPPNTL 73
Query: 1455 LYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDRETT------- 1506
+ + A D P+ Y+L E P LR+D +TG + + +DRE
Sbjct: 74 IGSLAA---DYGFPDVGHLYKL---EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQL 127
Query: 1507 ---PALLLL-VEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPG 1561
P +L V TD N S R + ++ V D NDN P FASP + +PE+ G
Sbjct: 128 PGDPCILEFEVSITDLVQNGSPRL---LEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1562 PAALHVVARDPDLGEAARVSYRLASGGDGH--FRLHSSTGA------LSVVRPLDREQRA 1613
+A D D G SY L +G + F L + L V+ LDRE+
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1614 EHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673
+ LT+ D GSPPR+++ +L V+V D ND AP F++ Y L EN+P G S++ ++A
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 1674 TDPDVGANGQVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728
D D GAN ++ Y V LD +TG++T +DRE+ + +V A+DRG+
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
Query: 1729 PPQLTHVTVRVAVEDENDHAPTF------------GSAHLSLEVPEGQDPQTLTMLRASD 1776
P+ V V V+D ND+APT G A++S +V E + +++ SD
Sbjct: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE---ETAVALVQVSD 421
Query: 1777 PDVGAN--------GQLQYRILDGDPSGAFVLDLASGEF-GTMRPLDREVEPAFQLRIEA 1827
D G N G + +++ +G+ D F T PLD E + + I A
Sbjct: 422 RDEGENAAVTCVVAGDVPFQLRQASETGS---DSKKKYFLQTTTPLDYEKVKDYTIEIVA 478
Query: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887
D G P LS+T L V V+D ND+AP F V PE+ G ++ ++ A D D+G+N
Sbjct: 479 VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
Query: 1888 GHVTYYLGAGTA--GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
+ Y L A G F + P +GE++ +LDREQ SY V A D + L T +
Sbjct: 539 AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTAT 597
Query: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAG 2005
V + V D ND+ P F S + P+ S + + D D G NA + +L+
Sbjct: 598 VLVNVLDCNDNDPKFMLSGYNFSVMENMPALS----PVGMVTVIDGDKGENAQV--QLSV 651
Query: 2006 TPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAER 2064
G + + TG I + S + A D G P RSA + + + E +
Sbjct: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
Query: 2065 GPRF--PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPST 2121
P P +S + G + A G N + YSI GN G F I +
Sbjct: 712 APYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHS 771
Query: 2122 GAITV 2126
GAIT+
Sbjct: 772 GAITL 776
Score = 242 bits (618), Expect = 4e-63
Identities = 245/878 (27%), Positives = 380/878 (43%), Gaps = 133/878 (15%)
Query: 2208 YSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMA--------------TDR 2252
Y L P VD TG I TT +DRE E + L
Sbjct: 90 YKLEVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
Query: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VL 2309
GSP L+ + V D NDN P P L + E+ +GS +D D+GP V
Sbjct: 147 GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
Query: 2310 WYVLSPSGPQDPFSVGRYGG--------RVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358
Y L +GP+ G ++ + G LD E+ D Y L + DG P
Sbjct: 204 SYELQ-AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
Query: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418
A L V V D NDNAP F + Y+ L E++P G +++ V A D D GAN I Y
Sbjct: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
Query: 2419 ADG----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474
+ +D N G L T+ G V + + + A+D G ++ARA V V ++D
Sbjct: 323 PEVVRRLLRLDRNTG-LITVQGPV--DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKD 379
Query: 2475 QNDHAPSFTLSHYRVA--------VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526
ND+AP+ + + ++ED+ + + ++ +D D + A +++G+
Sbjct: 380 MNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT--CVVAGD 437
Query: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586
+ +L +A E+ G + L PLD+E + Y + + A D G PP SS
Sbjct: 438 ------VPFQLRQASET-GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490
Query: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646
+ V V+DVNDN PVFT++ V PE+ G + + ASDAD G + + +++
Sbjct: 491 SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
Query: 2647 S-GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGP 2704
+ GLF + +G +++ +LD E + ++L V AAD A V + V D ND+ P
Sbjct: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610
Query: 2705 AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSST 2764
F L+ + SV EN P + V + IDGD G +++ S+ + F + + T
Sbjct: 611 KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV------EQDNGDFVIQNGT 664
Query: 2765 GELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPA--FHF 2820
G + + + FD E ++ + A D G SA V V++ V E++ P AP+ H
Sbjct: 665 GTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHK 724
Query: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYLRVDSRAPG 2878
+ R G ++ V A D D G + ++YS+A +PY F I +GA+ L +
Sbjct: 725 LLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI---- 780
Query: 2879 SGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDIT-------HTALGLAP 2931
R L ++V RG P +A V + V+ T T LG +
Sbjct: 781 ----------ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSL 830
Query: 2932 DLNL------------------LLVGAVAASLGVVVVLALAALVLGLVRARSRKAEA--- 2970
D L +L G VA + V +++ALA LV R R+A++
Sbjct: 831 DTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVR---YCRQREAKSGYQ 887
Query: 2971 ----------APGPMSQAAPLASDSLQKLGREPPSPPP 2998
AP P + AS + G++ SP P
Sbjct: 888 AGKKETKDLYAPKPSGK----ASKGNKSKGKKSKSPKP 921
Score = 242 bits (617), Expect = 5e-63
Identities = 221/772 (28%), Positives = 337/772 (43%), Gaps = 62/772 (8%)
Query: 474 RQLYR-PEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSG-IIT 531
R +Y+ PE P L GS PD G Y L GA + +D +G I T
Sbjct: 59 RVVYKVPEEQPPNTLIGSLAADYGF--PDVGH----LYKLEVGAP--YLRVDGKTGDIFT 110
Query: 532 TAASLDYE--LEPQPQL------------IVVATDGGLPPLASSATVSVALQDVNDNEPQ 577
T S+D E E Q QL I G P L + +QD+NDN P
Sbjct: 111 TETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDINDNTPN 167
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI----DA 633
F ++PE T G+ F A+D D+GP G+ SY L AG + ++ +
Sbjct: 168 FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEE 227
Query: 634 HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYA 691
+ LDR++ S+D T+ DGG S ++V + D NDN P+F Y
Sbjct: 228 KQPQLIVMGNLDRERW-DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYE 286
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY--HILAGNSPPLFTLDEQSGLLTVAWPLA 749
A +S SP G +V++++A+D DQG++ + Y H L LD +GL+TV P+
Sbjct: 287 AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVD 346
Query: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE--------QLQYVFSVPE 801
R S ++ + A+D G A+V +++ P E + ++ E
Sbjct: 347 REDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406
Query: 802 DVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSG------LLQTLRPLDR 854
DVA T+V +VQ + G A VT ++G P L LQT PLD
Sbjct: 407 DVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDY 466
Query: 855 ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY 914
E + V SG PP + ++V + DVNDN+P F V P N PG I
Sbjct: 467 EKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIA 526
Query: 915 TLRALDPDSGVNSRVTFTLLA--GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972
+ A D DSG N+ + ++L G FT+ P TG +++ L ++EL++ A D
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAAD 586
Query: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031
GSP + V V D P+F Y + A + V V D G
Sbjct: 587 RGSPSLQGTATVLVNVLDCNDND--PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 644
Query: 1032 ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATV 1091
L+ E + F ++ +G + + DRE Q Y ++ AV G G V
Sbjct: 645 AQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---V 701
Query: 1092 RVSILNQNEHSPRLS--EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149
+++L++N+++P ++ + + + G +V +V A D DSG N L YS+
Sbjct: 702 TINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAG-GN 760
Query: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201
F+I +G +T + ++R ++L+V+V D G PPR T VH+ V
Sbjct: 761 PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 227 bits (579), Expect = 1e-58
Identities = 207/695 (29%), Positives = 300/695 (43%), Gaps = 65/695 (9%)
Query: 2132 LDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLL 2191
L+FEVS + G+ + +QD NDN P F P +PE+ + G L
Sbjct: 134 LEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI-GSLF 187
Query: 2192 QVE-ADDLDQGSGGQISYSLAASQPARGLFHV------DPTTGTITTTAILDREIWAETR 2244
+ A D D G G SY L A A+ LF + + + LDRE W
Sbjct: 188 PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDV 2303
L + D GSP SA L V V+DTNDN P +P +E +SE++ +G + QV ND
Sbjct: 248 LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307
Query: 2304 DSGP----VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356
D G + +P + + R G +++ GP+D E + +LA D P
Sbjct: 308 DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367
Query: 2357 EGRANLTVLVEDVNDNAPAF--------SQSLYQVMLLEHTPPGSAILSVSATDRDSGAN 2408
RA + V V+D+NDNAP + + E +A+ V +DRD G N
Sbjct: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 2409 --------GHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
G + + L ++ S L T T L ++ + + A D G P
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---TTPLDYEKVKDYTIEIVAVDSGNP 484
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
++ ++ VQ+ D ND+AP FT S VA E+ PG + + A+DAD S S+A + Y
Sbjct: 485 PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVY 543
Query: 2521 SIISGNWGRVFQLEPRLAEAGE-SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ 2579
S LEP A G + P G + + LD E Y L V AADRG
Sbjct: 544 S-----------LEPEPAAKGLFTISP---ETGEIQVKTSLDREQRESYELKVVAADRGS 589
Query: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639
P V V VLD NDN P F + Y +V E+ P + + V D D G + V+
Sbjct: 590 PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649
Query: 2640 TVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAHFALAPVTIEVQD 2698
+V +G F + +GT+ + + D E Q+ + ++A D A VTI V D
Sbjct: 650 SVE--QDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
Query: 2699 VNDHGP--AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
ND+ P P N + G V+ + A D D+G L YS+ AG P G
Sbjct: 708 ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI--AGGNPYG-- 763
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791
F + S +G + + H RL+V +D G
Sbjct: 764 LFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Score = 216 bits (551), Expect = 2e-55
Identities = 218/775 (28%), Positives = 331/775 (42%), Gaps = 59/775 (7%)
Query: 1748 APTFGSA-HLSLEVPEGQDPQTLTMLRASD---PDVGANGQLQ----YRILDGDPSGAFV 1799
AP+ G A + +VPE Q P TL A+D PDVG +L+ Y +DG F
Sbjct: 51 APSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFT 110
Query: 1800 LDLASGEFGTMRPLDREV--EPAF-QLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
+ + G +R ++ +P + + D Q L + V D ND+ P F
Sbjct: 111 TETSIDREG-LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFA 169
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL--------EPSS 1908
P ++ +PE+ G+L A D DAG NG +Y L AG L E
Sbjct: 170 SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQ 229
Query: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLR 1968
+L LDRE+ SY ++ DG + P +++ + +TV D ND+AP F
Sbjct: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAE 288
Query: 1969 LPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV---DSYTGEIRVARS 2025
L P + + ++A D D GANA I Y P + D TG I V +
Sbjct: 289 LSENSPIGHS----VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QG 343
Query: 2026 PVALGPRDRVLF-IVATDLGRPARSATGVIIVGLQGEAERGPRFP--------RASSEAT 2076
PV + F ++A D G +SA ++V ++ + P A
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 2077 IRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAIT-----VRSAE 2130
I E+ T + + G N +T +++G+ TG+ + +++
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTT 462
Query: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVLTLTLQ--DANDNAPRFLRPHYVAFLPESRPLE 2187
LD+E V ++ +SG + +L +Q D NDNAP F + PE+
Sbjct: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247
+ ++ A D D GS ++ YSL A+GLF + P TG I LDRE L +
Sbjct: 523 EVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKV 582
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSG 2306
+A DRGSP+L G+AT+ V V+D NDN P + + V E+ S + VT D D G
Sbjct: 583 VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 2307 PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLT 2363
LS F + G + + D EQ Y QL A DG P +T
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702
Query: 2364 VLVEDVNDNAPAFS--QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLA--SPA 2419
+ V D NDNAP + + +L T G + V+A D DSG N + Y +A +P
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPY 762
Query: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474
F + ++G + T+ + H G +V++ D G P R A VH+ + +
Sbjct: 763 GLFQIGSHSGAI-TLEKEIERRHHGLHR--LVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 207 bits (528), Expect = 1e-52
Identities = 161/545 (29%), Positives = 239/545 (43%), Gaps = 26/545 (4%)
Query: 46 SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
S + ++ E P G + + A A + + Q V L +D ++G++
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 106 VLDREQRDRYRFTAVT------PDGATVEVTVRVADINDHAPAFPQARAAL--------Q 151
+DRE RF+ + P A +V V V D+ND+AP L
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211
+ E A T L D D G ++GD + R + G D L T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKKKYFLQTTT 462
Query: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271
LD E Y +++ A D G+PP + L V ++D+ND+AP F QS E+ PG
Sbjct: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
Query: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
+ ++ ASDAD+G N + Y + + G F+I TG +Q++ LD EQR +EL
Sbjct: 523 EVIAEITASDADSGSNAELVYSLEPEPA-AKGLFTISPETGEIQVKTSLDREQRESYELK 581
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391
V A D G+ G+A V V+V D NDN P F+ + + V E P V ++V
Sbjct: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPK----FMLSGYNFSVMENMPALSPVGMVTVI 637
Query: 392 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451
D D G+ A V +S+E G F + I + DRE++ Y ++ A D G PP
Sbjct: 638 DGDKGENAQVQLSVEQDNGDFVIQNGTGTILS---SLSFDREQQSTYTFQLKAVDGGVPP 694
Query: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPL--PEVALPGSFVVRVTARDPDQGTNGQVT 509
A ++V D NDNAP L P+ L G V +V A D D G N ++
Sbjct: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVNAELI 753
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
YS+A G F I SG IT ++ +L+V +D G PP +A V + +
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 570 DVNDN 574
+ N
Sbjct: 814 ETLAN 818
Score = 197 bits (500), Expect = 2e-49
Identities = 191/685 (27%), Positives = 286/685 (41%), Gaps = 57/685 (8%)
Query: 985 RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHL-AAEG 1040
++ VQD+ P F SP + +P T G+ A D GP +Y L A
Sbjct: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1041 ASSPFGL------EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVS 1094
A FGL E + L V LDRE + Y L + G + +A +RV+
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP---RASSALLRVT 269
Query: 1095 ILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED-SKA 1153
+L+ N+++P+ ++EN P G SV +V A D D G N + Y+ Q E +
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
R+ TG +T +DRE S+ + V +D G+ P+S V V V D+NDN+PT
Sbjct: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI-- 387
Query: 1214 ASGAAGGGLPIQ------VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP-------G 1260
G GL + + V T V +Q D DEGEN + + G
Sbjct: 388 --EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 1261 SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP 1320
SE S L T PL + Y + + A D G+PP S++ L VQV+
Sbjct: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV-------- 497
Query: 1321 PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGT 1378
D+ + P V V E +PG ++ + A + +G A L Y+L +G
Sbjct: 498 --DVNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554
Query: 1379 FALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFAR 1438
F + +G + + LD E + V A+ + V V V D N++ P F
Sbjct: 555 FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614
Query: 1439 DPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAP 1498
++ EN + + D D G N+ V+ L E + TG + +
Sbjct: 615 SGYNFSVMENMPALSPVGMVTVIDGD-KGENAQVQ---LSVEQDNGDFVIQNGTGTILSS 670
Query: 1499 RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVR---LP 1555
DRE ++A D R+A V + V DENDNAP +PS L
Sbjct: 671 LSFDREQQSTYTFQLKAVD---GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLT 727
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAE 1614
G V A D D G A + Y +A G G F++ S +GA+++ + ++R
Sbjct: 728 PQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787
Query: 1615 HVLTVVASDHGSPPRSATQVLTVSV 1639
H L V SD G PPR T ++ + V
Sbjct: 788 HRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 189 bits (479), Expect = 5e-47
Identities = 199/774 (25%), Positives = 334/774 (43%), Gaps = 88/774 (11%)
Query: 796 VFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSG-LLQTLRPLDR 854
V+ VPE+ P T +G + A + + L G P +D +G + T +DR
Sbjct: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHL-YKLEVGAP--YLRVDGKTGDIFTTETSIDR 117
Query: 855 ELLGP----------VLELEVRAGSGVP---PAFAVARVRVLLDDVNDNSPAFPAPEDTV 901
E L +LE EV V P ++ V D+NDN+P F +P T+
Sbjct: 118 EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV--QDINDNTPNFASPVITL 175
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG--------AFTVDPTTGHVRLM 953
+P NT G+ A D D+G N ++ L AG A + + +M
Sbjct: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235
Query: 954 RPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGT 1013
L +++L ++ +DGGSPPR S LRV V D T AP+F P+Y +L +
Sbjct: 236 GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD--TNDNAPKFERPSYEAELSENS 293
Query: 1014 TAGTQVLQVQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELY 1068
G V+QV+A D G T+H A E L+ +G + V+ +DRE +L
Sbjct: 294 PIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRE--DLS 351
Query: 1069 ILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL--------SEDPTFLAVAENQPP 1120
L+ ++ + ++ A V V++ + N+++P + + ++E+
Sbjct: 352 TLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 1121 GTSVGRVFATDRDSGPNGRLT--------YSLQQLSE---DSKAFRIHPQTGEVTTLQTL 1169
T+V V +DRD G N +T + L+Q SE DSK + + T L
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK------KKYFLQTTTPL 464
Query: 1170 DREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDR 1229
D E+ Y + + D G+PP S+T ++ V V+D+NDN+P F Q+ + P+
Sbjct: 465 DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV------TEVAFPEN 518
Query: 1230 VPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSE-LFSLHPHSGELLTAAPLIRAERPHY 1287
PG ++ + A D D G N ++Y+L P ++ LF++ P +GE+ L R +R Y
Sbjct: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
Query: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
L + A D+GSP + +LV VL D + DP + + E +
Sbjct: 579 ELKVVAADRGSPSLQGTATVLVNVL----------DCNDNDPKFMLS-GYNFSVMENMPA 627
Query: 1348 GSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTV 1407
S +G V + G + G F + +G + + D E +
Sbjct: 628 LSPVGMVTVID-GDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 1408 RAEGPGGAGARLLRVQVQVQDENEHAP---AFARDPLALALPENPEPGAALYTFRASDAD 1464
+G + + V + V DEN++AP A + L P+ G + A D D
Sbjct: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFD 745
Query: 1465 GPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR 1518
G N+++ Y + P ++ + +GA++ + ++R L+V+ +DR
Sbjct: 746 S-GVNAELIYSIAGGN-PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 187 bits (476), Expect = 1e-46
Identities = 175/649 (26%), Positives = 283/649 (43%), Gaps = 74/649 (11%)
Query: 788 PIFEQLQYVFSVPEDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGDPRGLFSLDAVSG 844
P F ++PE+ G+ I A + P +A L +G + + LF L
Sbjct: 166 PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ-AGPEAQELFGLQVAED 224
Query: 845 L------LQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897
L + LDRE L ++V+ G G PP + A +RV + D NDN+P F P
Sbjct: 225 QEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-GSPPRASSALLRVTVLDTNDNAPKFERP 283
Query: 898 EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVDPTTGHVRLMR 954
L N+ G + ++A D D G N+ + +T +D TG + +
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV------- 1007
P+ + A+D G+ P+++ ++ V V+D+ N+PT +
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND-------NAPTIEIRGIGLVT 396
Query: 1008 ------DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG--------- 1052
++ T V VQ D G PF L S
Sbjct: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
Query: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFL 1112
+L LD E + Y ++++AV L + T +++V +++ N+++P ++ T +
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPL---SSTNSLKVQVVDVNDNAPVFTQSVTEV 513
Query: 1113 AVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE 1172
A EN PG + + A+D DSG N L YSL+ F I P+TGE+ +LDRE
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573
Query: 1173 QQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPP 1232
Q+ SY+L V D GSP T TV V VLD NDN P F+ + G V + +P
Sbjct: 574 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS------GYNFSVMENMPA 627
Query: 1233 GTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLS 1292
+ V + D D+GEN + ++ + F + +G +L++ R ++ Y L
Sbjct: 628 LSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 1293 AHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG 1352
A D G PPRSA + + + VL + + AP + T+ + L P + LG
Sbjct: 687 AVDGGVPPRSAYVGVTINVL-------------DENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 1353 ----SVAAPE-PAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
VAA + +GV A L Y++ GG +P G F + + SG + L + ++
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGG-NPYGLFQIGSHSGAITLEKEIE 781
Score = 144 bits (364), Expect = 1e-33
Identities = 147/573 (25%), Positives = 249/573 (43%), Gaps = 75/573 (13%)
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446
E PP + I S++A D GH+ Y L A VD G +FT ++ D G
Sbjct: 66 EEQPPNTLIGSLAA-DYGFPDVGHL-YKLEVGAPYLRVDGKTGDIFTTETSI----DREG 119
Query: 2447 A-------------VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
++ + D G +++QD ND+ P+F +A+ E
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPE 179
Query: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPRLAEAGESAGPGPRALG 2552
+ GS A+D D + A Y + +G + +F L+ +AE E P
Sbjct: 180 NTNIGSLFPIPLASDRDAGPNGVA-SYELQAGPEAQELFGLQ--VAEDQEEKQPQ----- 231
Query: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
L+++ LD E Y+LT+ D G PP++S + VTVLD NDN P F R SY +
Sbjct: 232 -LIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
Query: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP--SGLFELDESSGTLRLAHALDCETQ 2670
E++P+G ++ V+A+D+D G + + +T L LD ++G + + +D E
Sbjct: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
Query: 2671 ARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLS--------TSVAENQPP 2721
+ + V A D A A V + V+D+ND+ P + + +++E+
Sbjct: 351 STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 2722 GTLVTTLHAIDGDAG--------AFGRLRYSLLEAG-PGPEGREAFALNSSTGELRARVP 2772
T V + D D G G + + L +A G + ++ + L ++T P
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------P 463
Query: 2773 FDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830
DYE + + + + A D+GN LS++ ++ V V ++ PVF PE + G
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523
Query: 2831 SLGHVQATDEDGGADGLVLYSL---ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGG 2887
+ + A+D D G++ ++YSL + F I+ TG + ++
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL------------- 570
Query: 2888 GRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
R +RE+ EL++ RG +ATV V V
Sbjct: 571 DREQRES-YELKVVAADRGSPSLQGTATVLVNV 602
Score = 117 bits (292), Expect = 2e-25
Identities = 99/345 (28%), Positives = 153/345 (44%), Gaps = 25/345 (7%)
Query: 48 DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGS-GVGTDLAIDEHSGVVRTAR 105
++ E G +I +I+A +G+ A L+Y + + + G+ T I +G ++
Sbjct: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFT---ISPETGEIQVKT 568
Query: 106 VLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
LDREQR+ Y V D T V V V D ND+ P F + V E+
Sbjct: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
Query: 160 TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 219
+ + D D G ++ D + T GT + L DRE +S
Sbjct: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGT-----GTILSSL----SFDREQQS 679
Query: 220 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFN--QSRYHAVVSESLAPGSPVLQV 277
Y QL+A DGG PPR A + + +LD ND+AP + H +++ G V QV
Sbjct: 680 TYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQV 739
Query: 278 FASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDG 337
A D D+GVN + Y I G F I +H+G + LE+ ++ +H LVV+ D
Sbjct: 740 AAEDFDSGVNAELIYSI--AGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Query: 338 GAHPELGSAFVTVHVRDANDNQPSM-TVIFLSADGSPQVSEAAPP 381
G P G+A V ++V + N+ + T++ S D + A P
Sbjct: 798 GKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDP 842
Score = 33.1 bits (74), Expect = 4.7
Identities = 52/216 (24%), Positives = 78/216 (36%), Gaps = 19/216 (8%)
Query: 2715 VAENQPPGTLVTTLHAIDG--DAGAFGRLRYSLLEAGPGPEGREAFALNSSTG-----EL 2767
V E QPP TL+ +L A G D G +L + + F +S E
Sbjct: 64 VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123
Query: 2768 RARVPFD---YEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPE 2824
+ ++P D E S LV L + V + ++ P F +P +PE
Sbjct: 124 QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI----NDNTPNFASPVITLAIPE 179
Query: 2825 GARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATS 2884
G A+D D G +G+ Y L Q L + D
Sbjct: 180 NTNIGSLFPIPLASDRDAGPNGVASYELQAGPE----AQELFGLQVAEDQEEKQPQLIVM 235
Query: 2885 GGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
G R R ++ +L ++V G P + SA + VTV
Sbjct: 236 GNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTV 270
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 348 bits (894), Expect = 4e-95
Identities = 264/784 (33%), Positives = 379/784 (48%), Gaps = 47/784 (5%)
Query: 16 SPRP---HLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISA--GLP- 69
SP P LLLP +LL LLLL A PG A + ++ EEQP TLIG ++A G P
Sbjct: 29 SPGPGGQRLLLPSMLLALLLLLAPSPG---HATRVVYKVPEEQPPNTLIGSLAADYGFPD 85
Query: 70 ------AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ---RDRYRFTAV 120
AP + + + G T+ +ID G+ L + T +
Sbjct: 86 VGHLYKLEVGAPYLR-VDGKTGDIFTTETSIDRE-GLRECQNQLPGDPCILEFEVSITDL 143
Query: 121 TPDGAT--VEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQ 178
+G+ +E + V DIND+ P F L +PE+T G+ +P+ A D DAG G
Sbjct: 144 VQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
Query: 179 GYAL-SGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRA 237
Y L +G A E F L+ + P+L+V G LDRE Y L ++ DGGSPPR +
Sbjct: 204 SYELQAGPEAQELFGLQVAEDQEEKQ-PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
Query: 238 QALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 297
ALL VT+LD ND+AP F + Y A +SE+ G V+QV A+D+D G N + Y ++
Sbjct: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
Query: 298 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357
+D +TGL+ ++ P+D E V A+D G +P+ A V V V+D ND
Sbjct: 323 PEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
Query: 358 NQPSMTV----IFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFA 413
N P++ + + DG +SE VA + VSD D+G+ A V + G+ F
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQ 441
Query: 414 L------STQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 467
L + Y + LD E+ Y + + A DSG+PPL + + + V DVND
Sbjct: 442 LRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND 501
Query: 468 NAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP-GAHTHWFSIDPT 526
NAP F Q PE PG + +TA D D G+N ++ YSL P A F+I P
Sbjct: 502 NAPVF-TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPE 560
Query: 527 SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 586
+G I SLD E +L VVA D G P L +ATV V + D NDN+P+F + YN S
Sbjct: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 587 LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDR 646
+ E + VT D D G + S+ G F I +G + ++ + DR
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTILSSLSFDR 675
Query: 647 DQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFYPREYAAS--ISAQSPPGT 702
+Q S++ F + AVDGG YV V ++ DENDN P + ++ Q+ G
Sbjct: 676 EQ-QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734
Query: 703 AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGA 762
V ++ A D D G + L Y I GN LF + SG +T+ + RR + + +L +
Sbjct: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 763 EDGG 766
D G
Sbjct: 795 SDRG 798
Score = 255 bits (651), Expect = 6e-67
Identities = 274/1033 (26%), Positives = 420/1033 (40%), Gaps = 118/1033 (11%)
Query: 1543 APVFASPSRVRLPEDQPPGPAALHVVARD---PDLGEAARVSYRLASGGDGHFRLHSSTG 1599
+P A+ ++PE+QPP + +A D PD+G Y+L G + R+ TG
Sbjct: 53 SPGHATRVVYKVPEEQPPN-TLIGSLAADYGFPDVGHL----YKLEVGAP-YLRVDGKTG 106
Query: 1600 ALSVVRP-LDREQRAE--------------HVLTVVASDHGSPPRSATQVLTVSVADVND 1644
+ +DRE E V +GSP Q+ V D+ND
Sbjct: 107 DIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI---EVQDIND 163
Query: 1645 EAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY----GGVSSESFSL---- 1696
P F ++ + EN G+ A+D D G NG +Y G + E F L
Sbjct: 164 NTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAE 223
Query: 1697 --DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754
+ L + LDRE + +LT+ QD GSPP+ + +RV V D ND+AP F
Sbjct: 224 DQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERP 283
Query: 1755 HLSLEVPEGQD-PQTLTMLRASDPDVGANGQLQYRILDGDP--SGAFVLDLASGEFGTMR 1811
E+ E ++ ++A+D D GAN +++Y LD +G
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 1812 PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV--------E 1863
P+DRE + + A+D G SA + VTV D ND+AP + +
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE-------LRTAAA 1916
+ EDV T + +Q D D G N VT + +G L+T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463
Query: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976
LD E+ YT + AVD PLS+T S+ + V DVND+AP F S + P
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN---- 518
Query: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGT--TVDSYTGEIRVARSPVALGPRDR 2034
+ P +A + A D D+G+NA ++Y L P T+ TGEI+V S
Sbjct: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
Query: 2035 VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVH 2094
L +VA D G P+ T ++V + + P+F + ++ EN P +P+ +
Sbjct: 579 ELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVID 638
Query: 2095 AG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA-- 2151
G N + S+ N G F IQ TG T+ S+ D E L+A GG
Sbjct: 639 GDKGENAQVQLSVEQDN--GDFVIQNGTG--TILSSLSFDREQQSTYTFQLKAVDGGVPP 694
Query: 2152 -FAFTVLTLTLQDANDNAPRFLRPHYVA---FLPESRPLEGPLLQVEADDLDQGSGGQIS 2207
A+ +T+ + D NDNAP P + P++R L + QV A+D D G ++
Sbjct: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAELI 753
Query: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267
YS+A P GLF + +G IT ++R RLV+ +DRG P G+A + + V
Sbjct: 754 YSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Query: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRY 2327
+T NR + + LLG + D+ P S + G
Sbjct: 813 NETLANRTLL----------ETLLGHSLDTPLDIDIAGDP----EYERSKQRGNILFGVV 858
Query: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387
G V++ + RY Q A G G+ +D+ P+ S +
Sbjct: 859 AGVVAVALLIALAVLVRYCRQREAKSGYQAGKKE----TKDLYAPKPSGKASKGNKSKGK 914
Query: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447
+ + V D ++G + ++L S A G S + + L +
Sbjct: 915 KSKSPKPVKPVEDED-EAGLQKSLKFNLMSDAPGDSPRIH----------LPLNYPPG-- 961
Query: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
+ D G R+ +QLQ Q +PS + H V +DLPP +T + T
Sbjct: 962 ------SPDLGRHYRSNSPLPSIQLQPQ---SPSASKKH---QVVQDLPPANTFVGTGDT 1009
Query: 2508 DADGSRSHAAVDY 2520
+ GS ++ Y
Sbjct: 1010 TSTGSEQYSDYSY 1022
Score = 253 bits (645), Expect = 3e-66
Identities = 234/785 (29%), Positives = 347/785 (44%), Gaps = 84/785 (10%)
Query: 1399 GPPWRALTVRAEGPGGAG----ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAA 1454
GPP + GPGG + LL + + + HA + +PE P
Sbjct: 19 GPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATR-----VVYKVPEEQPPNTL 73
Query: 1455 LYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDRETT------- 1506
+ + A D P+ Y+L E P LR+D +TG + + +DRE
Sbjct: 74 IGSLAA---DYGFPDVGHLYKL---EVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQL 127
Query: 1507 ---PALLLL-VEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPG 1561
P +L V TD N S R + ++ V D NDN P FASP + +PE+ G
Sbjct: 128 PGDPCILEFEVSITDLVQNGSPRL---LEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 1562 PAALHVVARDPDLGEAARVSYRLASGGDGH--FRLHSSTGA------LSVVRPLDREQRA 1613
+A D D G SY L +G + F L + L V+ LDRE+
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 1614 EHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673
+ LT+ D GSPPR+++ +L V+V D ND AP F++ Y L EN+P G S++ ++A
Sbjct: 245 SYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKA 304
Query: 1674 TDPDVGANGQVTY-----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGS 1728
D D GAN ++ Y V LD +TG++T +DRE+ + +V A+DRG+
Sbjct: 305 NDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT 364
Query: 1729 PPQLTHVTVRVAVEDENDHAPTF------------GSAHLSLEVPEGQDPQTLTMLRASD 1776
P+ V V V+D ND+APT G A++S +V E + +++ SD
Sbjct: 365 NPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE---ETAVALVQVSD 421
Query: 1777 PDVGAN--------GQLQYRILDGDPSGAFVLDLASGEF-GTMRPLDREVEPAFQLRIEA 1827
D G N G + +++ +G+ D F T PLD E + + I A
Sbjct: 422 RDEGENAAVTCVVAGDVPFQLRQASETGS---DSKKKYFLQTTTPLDYEKVKDYTIEIVA 478
Query: 1828 RDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887
D G P LS+T L V V+D ND+AP F V PE+ G ++ ++ A D D+G+N
Sbjct: 479 VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN 538
Query: 1888 GHVTYYLGAGTA--GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS 1945
+ Y L A G F + P +GE++ +LDREQ SY V A D + L T +
Sbjct: 539 AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTAT 597
Query: 1946 VTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAG 2005
V + V D ND+ P F S + P+ S + + D D G NA + +L+
Sbjct: 598 VLVNVLDCNDNDPKFMLSGYNFSVMENMPALS----PVGMVTVIDGDKGENAQV--QLSV 651
Query: 2006 TPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAER 2064
G + + TG I + S + A D G P RSA + + + E +
Sbjct: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDN 711
Query: 2065 GPRF--PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPST 2121
P P +S + G + A G N + YSI GN G F I +
Sbjct: 712 APYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHS 771
Query: 2122 GAITV 2126
GAIT+
Sbjct: 772 GAITL 776
Score = 242 bits (618), Expect = 4e-63
Identities = 245/878 (27%), Positives = 380/878 (43%), Gaps = 133/878 (15%)
Query: 2208 YSLAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMA--------------TDR 2252
Y L P VD TG I TT +DRE E + L
Sbjct: 90 YKLEVGAP---YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQN 146
Query: 2253 GSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VL 2309
GSP L+ + V D NDN P P L + E+ +GS +D D+GP V
Sbjct: 147 GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVA 203
Query: 2310 WYVLSPSGPQDPFSVGRYGG--------RVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358
Y L +GP+ G ++ + G LD E+ D Y L + DG P
Sbjct: 204 SYELQ-AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRAS 262
Query: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418
A L V V D NDNAP F + Y+ L E++P G +++ V A D D GAN I Y
Sbjct: 263 SALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA 322
Query: 2419 ADG----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474
+ +D N G L T+ G V + + + A+D G ++ARA V V ++D
Sbjct: 323 PEVVRRLLRLDRNTG-LITVQGPV--DREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKD 379
Query: 2475 QNDHAPSFTLSHYRVA--------VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN 2526
ND+AP+ + + ++ED+ + + ++ +D D + A +++G+
Sbjct: 380 MNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT--CVVAGD 437
Query: 2527 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2586
+ +L +A E+ G + L PLD+E + Y + + A D G PP SS
Sbjct: 438 ------VPFQLRQASET-GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTN 490
Query: 2587 PVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP 2646
+ V V+DVNDN PVFT++ V PE+ G + + ASDAD G + + +++
Sbjct: 491 SLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
Query: 2647 S-GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGP 2704
+ GLF + +G +++ +LD E + ++L V AAD A V + V D ND+ P
Sbjct: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610
Query: 2705 AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSST 2764
F L+ + SV EN P + V + IDGD G +++ S+ + F + + T
Sbjct: 611 KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV------EQDNGDFVIQNGT 664
Query: 2765 GELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPA--FHF 2820
G + + + FD E ++ + A D G SA V V++ V E++ P AP+ H
Sbjct: 665 GTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHK 724
Query: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYLRVDSRAPG 2878
+ R G ++ V A D D G + ++YS+A +PY F I +GA+ L +
Sbjct: 725 LLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI---- 780
Query: 2879 SGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDIT-------HTALGLAP 2931
R L ++V RG P +A V + V+ T T LG +
Sbjct: 781 ----------ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSL 830
Query: 2932 DLNL------------------LLVGAVAASLGVVVVLALAALVLGLVRARSRKAEA--- 2970
D L +L G VA + V +++ALA LV R R+A++
Sbjct: 831 DTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVR---YCRQREAKSGYQ 887
Query: 2971 ----------APGPMSQAAPLASDSLQKLGREPPSPPP 2998
AP P + AS + G++ SP P
Sbjct: 888 AGKKETKDLYAPKPSGK----ASKGNKSKGKKSKSPKP 921
Score = 242 bits (617), Expect = 5e-63
Identities = 221/772 (28%), Positives = 337/772 (43%), Gaps = 62/772 (8%)
Query: 474 RQLYR-PEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSG-IIT 531
R +Y+ PE P L GS PD G Y L GA + +D +G I T
Sbjct: 59 RVVYKVPEEQPPNTLIGSLAADYGF--PDVGH----LYKLEVGAP--YLRVDGKTGDIFT 110
Query: 532 TAASLDYE--LEPQPQL------------IVVATDGGLPPLASSATVSVALQDVNDNEPQ 577
T S+D E E Q QL I G P L + +QD+NDN P
Sbjct: 111 TETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG---QIEVQDINDNTPN 167
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI----DA 633
F ++PE T G+ F A+D D+GP G+ SY L AG + ++ +
Sbjct: 168 FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEE 227
Query: 634 HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYA 691
+ LDR++ S+D T+ DGG S ++V + D NDN P+F Y
Sbjct: 228 KQPQLIVMGNLDRERW-DSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYE 286
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY--HILAGNSPPLFTLDEQSGLLTVAWPLA 749
A +S SP G +V++++A+D DQG++ + Y H L LD +GL+TV P+
Sbjct: 287 AELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVD 346
Query: 750 RRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE--------QLQYVFSVPE 801
R S ++ + A+D G A+V +++ P E + ++ E
Sbjct: 347 REDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISE 406
Query: 802 DVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVSG------LLQTLRPLDR 854
DVA T+V +VQ + G A VT ++G P L LQT PLD
Sbjct: 407 DVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDY 466
Query: 855 ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY 914
E + V SG PP + ++V + DVNDN+P F V P N PG I
Sbjct: 467 EKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIA 526
Query: 915 TLRALDPDSGVNSRVTFTLLA--GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972
+ A D DSG N+ + ++L G FT+ P TG +++ L ++EL++ A D
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAAD 586
Query: 973 GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031
GSP + V V D P+F Y + A + V V D G
Sbjct: 587 RGSPSLQGTATVLVNVLDCNDND--PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 644
Query: 1032 ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATV 1091
L+ E + F ++ +G + + DRE Q Y ++ AV G G V
Sbjct: 645 AQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---V 701
Query: 1092 RVSILNQNEHSPRLS--EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149
+++L++N+++P ++ + + + G +V +V A D DSG N L YS+
Sbjct: 702 TINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAG-GN 760
Query: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201
F+I +G +T + ++R ++L+V+V D G PPR T VH+ V
Sbjct: 761 PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 227 bits (579), Expect = 1e-58
Identities = 207/695 (29%), Positives = 300/695 (43%), Gaps = 65/695 (9%)
Query: 2132 LDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLL 2191
L+FEVS + G+ + +QD NDN P F P +PE+ + G L
Sbjct: 134 LEFEVS-----ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNI-GSLF 187
Query: 2192 QVE-ADDLDQGSGGQISYSLAASQPARGLFHV------DPTTGTITTTAILDREIWAETR 2244
+ A D D G G SY L A A+ LF + + + LDRE W
Sbjct: 188 PIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDV 2303
L + D GSP SA L V V+DTNDN P +P +E +SE++ +G + QV ND
Sbjct: 248 LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307
Query: 2304 DSGP----VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356
D G + +P + + R G +++ GP+D E + +LA D P
Sbjct: 308 DQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK 367
Query: 2357 EGRANLTVLVEDVNDNAPAF--------SQSLYQVMLLEHTPPGSAILSVSATDRDSGAN 2408
RA + V V+D+NDNAP + + E +A+ V +DRD G N
Sbjct: 368 SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 427
Query: 2409 --------GHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
G + + L ++ S L T T L ++ + + A D G P
Sbjct: 428 AAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---TTPLDYEKVKDYTIEIVAVDSGNP 484
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520
++ ++ VQ+ D ND+AP FT S VA E+ PG + + A+DAD S S+A + Y
Sbjct: 485 PLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD-SGSNAELVY 543
Query: 2521 SIISGNWGRVFQLEPRLAEAGE-SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ 2579
S LEP A G + P G + + LD E Y L V AADRG
Sbjct: 544 S-----------LEPEPAAKGLFTISP---ETGEIQVKTSLDREQRESYELKVVAADRGS 589
Query: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639
P V V VLD NDN P F + Y +V E+ P + + V D D G + V+
Sbjct: 590 PSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQL 649
Query: 2640 TVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAHFALAPVTIEVQD 2698
+V +G F + +GT+ + + D E Q+ + ++A D A VTI V D
Sbjct: 650 SVE--QDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707
Query: 2699 VNDHGP--AFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
ND+ P P N + G V+ + A D D+G L YS+ AG P G
Sbjct: 708 ENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI--AGGNPYG-- 763
Query: 2757 AFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791
F + S +G + + H RL+V +D G
Sbjct: 764 LFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRG 798
Score = 216 bits (551), Expect = 2e-55
Identities = 218/775 (28%), Positives = 331/775 (42%), Gaps = 59/775 (7%)
Query: 1748 APTFGSA-HLSLEVPEGQDPQTLTMLRASD---PDVGANGQLQ----YRILDGDPSGAFV 1799
AP+ G A + +VPE Q P TL A+D PDVG +L+ Y +DG F
Sbjct: 51 APSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFT 110
Query: 1800 LDLASGEFGTMRPLDREV--EPAF-QLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
+ + G +R ++ +P + + D Q L + V D ND+ P F
Sbjct: 111 TETSIDREG-LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFA 169
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL--------EPSS 1908
P ++ +PE+ G+L A D DAG NG +Y L AG L E
Sbjct: 170 SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQ 229
Query: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLR 1968
+L LDRE+ SY ++ DG + P +++ + +TV D ND+AP F
Sbjct: 230 PQLIVMGNLDRERWDSYDLTIKVQDGGSP-PRASSALLRVTVLDTNDNAPKFERPSYEAE 288
Query: 1969 LPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV---DSYTGEIRVARS 2025
L P + + ++A D D GANA I Y P + D TG I V +
Sbjct: 289 LSENSPIGHS----VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QG 343
Query: 2026 PVALGPRDRVLF-IVATDLGRPARSATGVIIVGLQGEAERGPRFP--------RASSEAT 2076
PV + F ++A D G +SA ++V ++ + P A
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 2077 IRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAIT-----VRSAE 2130
I E+ T + + G N +T +++G+ TG+ + +++
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTT 462
Query: 2131 GLDFE-VSPRLRLVLQAESGGAFAFTVLTLTLQ--DANDNAPRFLRPHYVAFLPESRPLE 2187
LD+E V ++ +SG + +L +Q D NDNAP F + PE+
Sbjct: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247
+ ++ A D D GS ++ YSL A+GLF + P TG I LDRE L +
Sbjct: 523 EVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKV 582
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVDSG 2306
+A DRGSP+L G+AT+ V V+D NDN P + + V E+ S + VT D D G
Sbjct: 583 VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 2307 PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLT 2363
LS F + G + + D EQ Y QL A DG P +T
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702
Query: 2364 VLVEDVNDNAPAFS--QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLA--SPA 2419
+ V D NDNAP + + +L T G + V+A D DSG N + Y +A +P
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPY 762
Query: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474
F + ++G + T+ + H G +V++ D G P R A VH+ + +
Sbjct: 763 GLFQIGSHSGAI-TLEKEIERRHHGLHR--LVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 207 bits (528), Expect = 1e-52
Identities = 161/545 (29%), Positives = 239/545 (43%), Gaps = 26/545 (4%)
Query: 46 SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
S + ++ E P G + + A A + + Q V L +D ++G++
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 106 VLDREQRDRYRFTAVT------PDGATVEVTVRVADINDHAPAFPQARAAL--------Q 151
+DRE RF+ + P A +V V V D+ND+AP L
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMAN 403
Query: 152 VPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTG 211
+ E A T L D D G ++GD + R + G D L T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKKKYFLQTTT 462
Query: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271
LD E Y +++ A D G+PP + L V ++D+ND+AP F QS E+ PG
Sbjct: 463 PLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG 522
Query: 272 SPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
+ ++ ASDAD+G N + Y + + G F+I TG +Q++ LD EQR +EL
Sbjct: 523 EVIAEITASDADSGSNAELVYSLEPEPA-AKGLFTISPETGEIQVKTSLDREQRESYELK 581
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 391
V A D G+ G+A V V+V D NDN P F+ + + V E P V ++V
Sbjct: 582 VVAADRGSPSLQGTATVLVNVLDCNDNDPK----FMLSGYNFSVMENMPALSPVGMVTVI 637
Query: 392 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451
D D G+ A V +S+E G F + I + DRE++ Y ++ A D G PP
Sbjct: 638 DGDKGENAQVQLSVEQDNGDFVIQNGTGTILS---SLSFDREQQSTYTFQLKAVDGGVPP 694
Query: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPL--PEVALPGSFVVRVTARDPDQGTNGQVT 509
A ++V D NDNAP L P+ L G V +V A D D G N ++
Sbjct: 695 RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVNAELI 753
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
YS+A G F I SG IT ++ +L+V +D G PP +A V + +
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 570 DVNDN 574
+ N
Sbjct: 814 ETLAN 818
Score = 197 bits (500), Expect = 2e-49
Identities = 191/685 (27%), Positives = 286/685 (41%), Gaps = 57/685 (8%)
Query: 985 RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHL-AAEG 1040
++ VQD+ P F SP + +P T G+ A D GP +Y L A
Sbjct: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1041 ASSPFGL------EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVS 1094
A FGL E + L V LDRE + Y L + G + +A +RV+
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP---RASSALLRVT 269
Query: 1095 ILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSED-SKA 1153
+L+ N+++P+ ++EN P G SV +V A D D G N + Y+ Q E +
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 1154 FRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
R+ TG +T +DRE S+ + V +D G+ P+S V V V D+NDN+PT
Sbjct: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI-- 387
Query: 1214 ASGAAGGGLPIQ------VPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP-------G 1260
G GL + + V T V +Q D DEGEN + + G
Sbjct: 388 --EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 1261 SELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP 1320
SE S L T PL + Y + + A D G+PP S++ L VQV+
Sbjct: 446 SETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV-------- 497
Query: 1321 PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGT 1378
D+ + P V V E +PG ++ + A + +G A L Y+L +G
Sbjct: 498 --DVNDNAPVFTQSVT-EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554
Query: 1379 FALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFAR 1438
F + +G + + LD E + V A+ + V V V D N++ P F
Sbjct: 555 FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614
Query: 1439 DPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAP 1498
++ EN + + D D G N+ V+ L E + TG + +
Sbjct: 615 SGYNFSVMENMPALSPVGMVTVIDGD-KGENAQVQ---LSVEQDNGDFVIQNGTGTILSS 670
Query: 1499 RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVR---LP 1555
DRE ++A D R+A V + V DENDNAP +PS L
Sbjct: 671 LSFDREQQSTYTFQLKAVD---GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLT 727
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAE 1614
G V A D D G A + Y +A G G F++ S +GA+++ + ++R
Sbjct: 728 PQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGL 787
Query: 1615 HVLTVVASDHGSPPRSATQVLTVSV 1639
H L V SD G PPR T ++ + V
Sbjct: 788 HRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 189 bits (479), Expect = 5e-47
Identities = 199/774 (25%), Positives = 334/774 (43%), Gaps = 88/774 (11%)
Query: 796 VFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSG-LLQTLRPLDR 854
V+ VPE+ P T +G + A + + L G P +D +G + T +DR
Sbjct: 61 VYKVPEEQPPNTLIGSLAADYGFPDVGHL-YKLEVGAP--YLRVDGKTGDIFTTETSIDR 117
Query: 855 ELLGP----------VLELEVRAGSGVP---PAFAVARVRVLLDDVNDNSPAFPAPEDTV 901
E L +LE EV V P ++ V D+NDN+P F +P T+
Sbjct: 118 EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV--QDINDNTPNFASPVITL 175
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG--------AFTVDPTTGHVRLM 953
+P NT G+ A D D+G N ++ L AG A + + +M
Sbjct: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235
Query: 954 RPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGT 1013
L +++L ++ +DGGSPPR S LRV V D T AP+F P+Y +L +
Sbjct: 236 GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD--TNDNAPKFERPSYEAELSENS 293
Query: 1014 TAGTQVLQVQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELY 1068
G V+QV+A D G T+H A E L+ +G + V+ +DRE +L
Sbjct: 294 PIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRE--DLS 351
Query: 1069 ILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL--------SEDPTFLAVAENQPP 1120
L+ ++ + ++ A V V++ + N+++P + + ++E+
Sbjct: 352 TLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 1121 GTSVGRVFATDRDSGPNGRLT--------YSLQQLSE---DSKAFRIHPQTGEVTTLQTL 1169
T+V V +DRD G N +T + L+Q SE DSK + + T L
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK------KKYFLQTTTPL 464
Query: 1170 DREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDR 1229
D E+ Y + + D G+PP S+T ++ V V+D+NDN+P F Q+ + P+
Sbjct: 465 DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV------TEVAFPEN 518
Query: 1230 VPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSE-LFSLHPHSGELLTAAPLIRAERPHY 1287
PG ++ + A D D G N ++Y+L P ++ LF++ P +GE+ L R +R Y
Sbjct: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
Query: 1288 VLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
L + A D+GSP + +LV VL D + DP + + E +
Sbjct: 579 ELKVVAADRGSPSLQGTATVLVNVL----------DCNDNDPKFMLS-GYNFSVMENMPA 627
Query: 1348 GSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTV 1407
S +G V + G + G F + +G + + D E +
Sbjct: 628 LSPVGMVTVID-GDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 1408 RAEGPGGAGARLLRVQVQVQDENEHAP---AFARDPLALALPENPEPGAALYTFRASDAD 1464
+G + + V + V DEN++AP A + L P+ G + A D D
Sbjct: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQT-RLGETVSQVAAEDFD 745
Query: 1465 GPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR 1518
G N+++ Y + P ++ + +GA++ + ++R L+V+ +DR
Sbjct: 746 S-GVNAELIYSIAGGN-PYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Score = 187 bits (476), Expect = 1e-46
Identities = 175/649 (26%), Positives = 283/649 (43%), Gaps = 74/649 (11%)
Query: 788 PIFEQLQYVFSVPEDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGDPRGLFSLDAVSG 844
P F ++PE+ G+ I A + P +A L +G + + LF L
Sbjct: 166 PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ-AGPEAQELFGLQVAED 224
Query: 845 L------LQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP 897
L + LDRE L ++V+ G G PP + A +RV + D NDN+P F P
Sbjct: 225 QEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-GSPPRASSALLRVTVLDTNDNAPKFERP 283
Query: 898 EDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVDPTTGHVRLMR 954
L N+ G + ++A D D G N+ + +T +D TG + +
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV------- 1007
P+ + A+D G+ P+++ ++ V V+D+ N+PT +
Sbjct: 344 PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND-------NAPTIEIRGIGLVT 396
Query: 1008 ------DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG--------- 1052
++ T V VQ D G PF L S
Sbjct: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
Query: 1053 WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFL 1112
+L LD E + Y ++++AV L + T +++V +++ N+++P ++ T +
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPL---SSTNSLKVQVVDVNDNAPVFTQSVTEV 513
Query: 1113 AVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE 1172
A EN PG + + A+D DSG N L YSL+ F I P+TGE+ +LDRE
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573
Query: 1173 QQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPP 1232
Q+ SY+L V D GSP T TV V VLD NDN P F+ + G V + +P
Sbjct: 574 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLS------GYNFSVMENMPA 627
Query: 1233 GTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLS 1292
+ V + D D+GEN + ++ + F + +G +L++ R ++ Y L
Sbjct: 628 LSPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 1293 AHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLG 1352
A D G PPRSA + + + VL + + AP + T+ + L P + LG
Sbjct: 687 AVDGGVPPRSAYVGVTINVL-------------DENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 1353 ----SVAAPE-PAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
VAA + +GV A L Y++ GG +P G F + + SG + L + ++
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGG-NPYGLFQIGSHSGAITLEKEIE 781
Score = 144 bits (364), Expect = 1e-33
Identities = 147/573 (25%), Positives = 249/573 (43%), Gaps = 75/573 (13%)
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446
E PP + I S++A D GH+ Y L A VD G +FT ++ D G
Sbjct: 66 EEQPPNTLIGSLAA-DYGFPDVGHL-YKLEVGAPYLRVDGKTGDIFTTETSI----DREG 119
Query: 2447 A-------------VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
++ + D G +++QD ND+ P+F +A+ E
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPE 179
Query: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPRLAEAGESAGPGPRALG 2552
+ GS A+D D + A Y + +G + +F L+ +AE E P
Sbjct: 180 NTNIGSLFPIPLASDRDAGPNGVA-SYELQAGPEAQELFGLQ--VAEDQEEKQPQ----- 231
Query: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
L+++ LD E Y+LT+ D G PP++S + VTVLD NDN P F R SY +
Sbjct: 232 -LIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
Query: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDP--SGLFELDESSGTLRLAHALDCETQ 2670
E++P+G ++ V+A+D+D G + + +T L LD ++G + + +D E
Sbjct: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
Query: 2671 ARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLS--------TSVAENQPP 2721
+ + V A D A A V + V+D+ND+ P + + +++E+
Sbjct: 351 STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 2722 GTLVTTLHAIDGDAG--------AFGRLRYSLLEAG-PGPEGREAFALNSSTGELRARVP 2772
T V + D D G G + + L +A G + ++ + L ++T P
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTT-------P 463
Query: 2773 FDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830
DYE + + + + A D+GN LS++ ++ V V ++ PVF PE + G
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523
Query: 2831 SLGHVQATDEDGGADGLVLYSL---ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGG 2887
+ + A+D D G++ ++YSL + F I+ TG + ++
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL------------- 570
Query: 2888 GRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
R +RE+ EL++ RG +ATV V V
Sbjct: 571 DREQRES-YELKVVAADRGSPSLQGTATVLVNV 602
Score = 117 bits (292), Expect = 2e-25
Identities = 99/345 (28%), Positives = 153/345 (44%), Gaps = 25/345 (7%)
Query: 48 DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGS-GVGTDLAIDEHSGVVRTAR 105
++ E G +I +I+A +G+ A L+Y + + + G+ T I +G ++
Sbjct: 512 EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFT---ISPETGEIQVKT 568
Query: 106 VLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
LDREQR+ Y V D T V V V D ND+ P F + V E+
Sbjct: 569 SLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628
Query: 160 TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 219
+ + D D G ++ D + T GT + L DRE +S
Sbjct: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGT-----GTILSSL----SFDREQQS 679
Query: 220 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFN--QSRYHAVVSESLAPGSPVLQV 277
Y QL+A DGG PPR A + + +LD ND+AP + H +++ G V QV
Sbjct: 680 TYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQV 739
Query: 278 FASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDG 337
A D D+GVN + Y I G F I +H+G + LE+ ++ +H LVV+ D
Sbjct: 740 AAEDFDSGVNAELIYSI--AGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Query: 338 GAHPELGSAFVTVHVRDANDNQPSM-TVIFLSADGSPQVSEAAPP 381
G P G+A V ++V + N+ + T++ S D + A P
Sbjct: 798 GKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDP 842
Score = 33.1 bits (74), Expect = 4.7
Identities = 52/216 (24%), Positives = 78/216 (36%), Gaps = 19/216 (8%)
Query: 2715 VAENQPPGTLVTTLHAIDG--DAGAFGRLRYSLLEAGPGPEGREAFALNSSTG-----EL 2767
V E QPP TL+ +L A G D G +L + + F +S E
Sbjct: 64 VPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLREC 123
Query: 2768 RARVPFD---YEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPE 2824
+ ++P D E S LV L + V + ++ P F +P +PE
Sbjct: 124 QNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDI----NDNTPNFASPVITLAIPE 179
Query: 2825 GARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATS 2884
G A+D D G +G+ Y L Q L + D
Sbjct: 180 NTNIGSLFPIPLASDRDAGPNGVASYELQAGPE----AQELFGLQVAEDQEEKQPQLIVM 235
Query: 2885 GGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
G R R ++ +L ++V G P + SA + VTV
Sbjct: 236 GNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTV 270
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 342 bits (876), Expect = 5e-93
Identities = 247/687 (35%), Positives = 356/687 (51%), Gaps = 50/687 (7%)
Query: 21 LLLPLLLLLLLLLGAGVPGAWGQAGSL---DLQIDEEQPAGTLIGDISAGL-PAGTAAPL 76
LLLP+LLLL +L W QA +L ++EEQ AGT+I +++ AG A
Sbjct: 4 LLLPVLLLLAIL--------WTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDP 55
Query: 77 MYFISAQEGSGVGTDLA-IDEHSGVVRTARVLDREQRDRYR------FTAVTPDGATVEV 129
+ + S L I+ SG++ T + +DR+ R ++ +
Sbjct: 56 RQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVI 115
Query: 130 TVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGE 189
V + D+ND+AP+FP A+ L++ E + GTR PL+ A D D+G G Q Y L+ + E
Sbjct: 116 KVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN---E 172
Query: 190 TFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDIN 249
F LE + DG+ ELVV LDRE +SHY ++ A DGG PPR L + + D N
Sbjct: 173 LFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN 232
Query: 250 DHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE----INRRQSEGDGPF 305
D+ P F++S Y V E+ P +PV+++ ASD D G NG V Y +N R E F
Sbjct: 233 DNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRE---LF 289
Query: 306 SIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVI 365
ID H+GL+ + LD+E+ V+EL VQA+D G + VTV V D NDN P + ++
Sbjct: 290 QIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLL 349
Query: 366 FLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVC 425
++++ +VSE+APPG ++A + VSD D G V L G F L +S +
Sbjct: 350 SVNSE-LVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNV-PFRLQEYES-FSTIL 406
Query: 426 VARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEV 485
V RLDRE+ D YNL + A D G P L++ +F + +TD NDN P F + Y+ + E
Sbjct: 407 VDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ-VIVQEN 465
Query: 486 ALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH-----WFSIDPTSGIITTAASLDYEL 540
PG++++ V+ARDPD G NG V+Y + P + SI+P SG I S ++E
Sbjct: 466 NTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQ 525
Query: 541 EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQR-TFYNAS----LPEGTQPGT 595
+ V+A DGGLP L S+ATV V + DVNDN P N + +P + G
Sbjct: 526 TKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGY 585
Query: 596 CFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF 655
V A D D G G ++Y + G F ID +G+V TTRT + SS++
Sbjct: 586 LVTVVKAEDYDEGENGRVTYDMTEG----DRGFFEIDQVNGEVRTTRTFG-ESSKSSYEL 640
Query: 656 TVTAVDGG--GLKSMVYVKVFLSDEND 680
V A D G L + V ++LS D
Sbjct: 641 IVVAHDHGKTSLSASALVLIYLSPALD 667
Score = 212 bits (539), Expect = 6e-54
Identities = 185/676 (27%), Positives = 294/676 (43%), Gaps = 60/676 (8%)
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEG------ENGTILYTLTGPGSELFS 1265
L AA L V + GT++ + AKD E + ++ L
Sbjct: 15 LWTQAAALINLKYSVEEEQRAGTVIANV-AKDAREAGFALDPRQASAFRVVSNSAPHLVD 73
Query: 1266 LHPHSGELLTAAPLIR----AERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPP 1321
++P SG L+T + R + P +++L S+S+++ V + L +
Sbjct: 74 INPSSGLLVTKQKIDRDLLCRQSPKCIISLEV-------MSSSMEICVIKVEIKDLNDNA 126
Query: 1322 PDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
P PAA + + ++ A+ G R L S P+ G TY L P F L
Sbjct: 127 PSF----PAAQIELEISEAASPGTRIP--LDSAYDPDSGSFGVQTYELT----PNELFGL 176
Query: 1382 DAAS-------GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAP 1434
+ + L + + LD E + +G + + ++V D N++ P
Sbjct: 177 EIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP 236
Query: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLR--QEPPVPALRLDART 1492
F+ A+++PEN P + ASD D G N V Y + ++D +
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQIDPHS 295
Query: 1493 GALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF----AS 1548
G ++ LD E L V+A D N+ A V V D NDN PV +
Sbjct: 296 GLVTVTGALDYEEGHVYELDVQAKDLGPNSI---PAHCKVTVSVLDTNDNPPVINLLSVN 352
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLD 1608
V + E PPG V D D G RV RL + + S + V LD
Sbjct: 353 SELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLD 412
Query: 1609 REQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSL 1668
REQ ++ LT+ A D G P + + TV + D ND P F + Y V+++ENN PG L
Sbjct: 413 REQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL 472
Query: 1669 LTLRATDPDVGANGQVTYGGVSSE--------SFSLDPDTGVLTTLRALDREEQEEINLT 1720
L++ A DPD+G NG V+Y V S+ S++P++G + LR+ + E+ +
Sbjct: 473 LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFK 532
Query: 1721 VYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT------LTMLRA 1774
V A+D G P ++ TVRV + D ND+ P + L E P+ +T+++A
Sbjct: 533 VLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKA 592
Query: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
D D G NG++ Y + +GD G F +D +GE T R + +++L + A D G+ +
Sbjct: 593 EDYDEGENGRVTYDMTEGD-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 1835 LSATLLLTVTVLDAND 1850
LSA+ L+ + + A D
Sbjct: 652 LSASALVLIYLSPALD 667
Score = 211 bits (536), Expect = 1e-53
Identities = 179/619 (28%), Positives = 284/619 (45%), Gaps = 51/619 (8%)
Query: 497 ARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL--EPQPQLIVVATDGG 554
A DP Q + +V + AP H I+P+SG++ T +D +L P+ I+
Sbjct: 52 ALDPRQASAFRVVSNSAP----HLVDINPSSGLLVTKQKIDRDLLCRQSPKCII-----S 102
Query: 555 LPPLASS---ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFG 611
L ++SS + V ++D+NDN P F + E PGT +A D DSG FG
Sbjct: 103 LEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFG 162
Query: 612 LLSYSL------GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGL 665
+ +Y L G + + G + ++ ++LDR+ S + F +TA+DGG
Sbjct: 163 VQTYELTPNELFGLEIKTRGD-----GSRFAELVVEKSLDRET-QSHYSFRITALDGGDP 216
Query: 666 KSM--VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723
+ V + + ++D NDN P F YA S+ SPP T V+RL A DPD+G++G++ Y
Sbjct: 217 PRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYS 276
Query: 724 I---LAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI 780
+ + LF +D SGL+TV L V +L++ A+D G +V +S+
Sbjct: 277 FYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSV 336
Query: 781 VPGTPTPPIFEQLQY---VFSVPEDVAPGTSVGIVQ-AHNPPGRLAPVTLSLSGGDPRGL 836
+ PP+ L + V E PG + +V+ + G V L G P L
Sbjct: 337 LDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL 396
Query: 837 FSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFP 895
++ S +L R LDRE L ++ R G GVP + VL+ D NDN P F
Sbjct: 397 QEYESFSTILVDGR-LDREQHDQYNLTIQARDG-GVPMLQSAKSFTVLITDENDNHPHFS 454
Query: 896 APEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG---GGGAFT---VDPTTGH 949
P V++ N PG + ++ A DPD G+N V++ ++ FT ++P +G
Sbjct: 455 KPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGD 514
Query: 950 VRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRG---LAPRFNSPTYR 1006
+ +R A E ++ A+DGG P S+ +RV++ DV AP + T
Sbjct: 515 IYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAE 574
Query: 1007 VDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDRE 1063
V +P + G V V+A+ D G +TY + EG F ++ +G +
Sbjct: 575 VYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDM-TEGDRGFFEIDQVNGEVRTTRTFGES 633
Query: 1064 AQELYILKVMAVSGSKAEL 1082
++ Y L V+A K L
Sbjct: 634 SKSSYELIVVAHDHGKTSL 652
Score = 209 bits (531), Expect = 5e-53
Identities = 166/603 (27%), Positives = 270/603 (44%), Gaps = 49/603 (8%)
Query: 1696 LDPDTGVLTTLRALDREE--QEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1753
++P +G+L T + +DR+ ++ + + S ++ ++V ++D ND+AP+F +
Sbjct: 74 INPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEIC--VIKVEIKDLNDNAPSFPA 131
Query: 1754 AHLSLEVPEGQDPQTLTML-RASDPDVGANGQLQYRILDGDPSGAFVLDLASG----EFG 1808
A + LE+ E P T L A DPD G+ G Y + + G + G E
Sbjct: 132 AQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELV 191
Query: 1809 TMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDV 1868
+ LDRE + + RI A DGG P T+ L++ V D+ND+ P F Y+V VPE+
Sbjct: 192 VEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENS 251
Query: 1869 PAGTLLLQLQAHDPDAGANGHVTY----YLGAGTAGAFLLEPSSGELRTAAALDREQCPS 1924
P T +++L A DPD G NG V Y Y+ T F ++P SG + ALD E+
Sbjct: 252 PPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHV 311
Query: 1925 YTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
Y V A D GP S VT++V D ND+ P + L S + P
Sbjct: 312 YELDVQAKD---LGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSES-APPGYV 367
Query: 1983 LATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV------L 2036
+A +R DRD+G N + RL G P E + + G DR L
Sbjct: 368 IALVRVSDRDSGLNGRVQCRLLGNVP------FRLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 2037 FIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG 2096
I A D G P + V + E + P F + + ++EN PG ++S A
Sbjct: 422 TIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD 481
Query: 2097 -GTNGPITYSILSGNEKGT-----FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG 2150
G NG ++Y I+ + SI P++G + + + E + + A+ GG
Sbjct: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSG--DIYALRSFNHEQTKAFEFKVLAKDGG 539
Query: 2151 AFAF---TVLTLTLQDANDNAPRFLRPHYV-----AFLPESRPLEGPLLQVEADDLDQGS 2202
+ + + + D NDN P P + ++P + + + V+A+D D+G
Sbjct: 540 LPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGE 599
Query: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSAT 2262
G+++Y + ++ RG F +D G + TT + L+++A D G +L SA
Sbjct: 600 NGRVTYDM--TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
Query: 2263 LTV 2265
+ +
Sbjct: 658 VLI 660
Score = 199 bits (507), Expect = 3e-50
Identities = 168/643 (26%), Positives = 274/643 (42%), Gaps = 66/643 (10%)
Query: 709 AHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLAR------RANSVVQLEIGA 762
A DP Q S ++ +++ ++P L ++ SGLL + R ++ LE+ +
Sbjct: 52 ALDPRQAS----AFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMS 107
Query: 763 EDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRL 821
+ + + I P F Q + E +PGT + + A++P G
Sbjct: 108 S------SMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSF 161
Query: 822 APVTLSLSGGDPRGLFSLDAVS-------GLLQTLRPLDRELLGPVLELEVRAGSGVPPA 874
T L+ P LF L+ + L + LDRE G PP
Sbjct: 162 GVQTYELT---PNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPR 218
Query: 875 FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL 934
+ + + D NDN+P F V +P N+ P TP+ L A DPD G N +V ++
Sbjct: 219 LGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFY 278
Query: 935 AGGGGA----FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQD 990
F +DP +G V + L G +EL+++A+D G +H ++ V V D
Sbjct: 279 GYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLD 338
Query: 991 VGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASS------- 1043
N P + + +++++V AP G I ++ S
Sbjct: 339 TND-------NPPVINL-----LSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQC 386
Query: 1044 ------PFGLEPQSGW--LWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI 1095
PF L+ + + V LDRE + Y L + A G L + V I
Sbjct: 387 RLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPML---QSAKSFTVLI 443
Query: 1096 LNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLS-EDSKAF 1154
++N++ P S+ + V EN PG + V A D D G NG ++Y + D F
Sbjct: 444 TDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVF 503
Query: 1155 R---IHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF 1211
I+P +G++ L++ + EQ +++ V +DGG P + TV V +LD+NDN+P
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPV- 562
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSG 1271
+ A G + +P G LVT ++A+D DEGENG + Y +T F + +G
Sbjct: 563 ITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNG 622
Query: 1272 ELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPS 1314
E+ T + + Y L + AHD G SAS +L+ + P+
Sbjct: 623 EVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPA 665
Score = 199 bits (506), Expect = 4e-50
Identities = 186/654 (28%), Positives = 282/654 (43%), Gaps = 68/654 (10%)
Query: 2205 QISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLT 2264
Q S S A L ++P++G + T +DR++ + + + + +
Sbjct: 57 QASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIK 116
Query: 2265 VMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDP 2321
V + D NDN P+ P EL +SE A G+ I + D DSG V Y L+P+ +
Sbjct: 117 VEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN---EL 173
Query: 2322 FSV-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVND 2371
F + G + + LD E Y ++ A DG P G L++ V D ND
Sbjct: 174 FGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSND 233
Query: 2372 NAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDP 2426
N P FS+S Y V + E++PP + ++ ++A+D D G NG + Y + F +DP
Sbjct: 234 NNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDP 293
Query: 2427 NNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
++G L T+ G AL ++ ++ ++A+D G A V V + D ND+ P L
Sbjct: 294 HSG-LVTVTG--ALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLS 350
Query: 2487 YR---VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGES 2543
V V+E PPG + + +D D SG GRV + RL
Sbjct: 351 VNSELVEVSESAPPGYVIALVRVSDRD-------------SGLNGRV---QCRLLGNVPF 394
Query: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT 2603
+ +++ LD E QYNLT+ A D G P S TV + D NDN P F+
Sbjct: 395 RLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFS 454
Query: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGL-----FELDESSGT 2658
+ Y+V V E+ GA LL V A D D G +G V + + + ++ +SG
Sbjct: 455 KPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGD 514
Query: 2659 LRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAE 2717
+ + + E + V A D + A V + + DVND+ P L AE
Sbjct: 515 IYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAE 574
Query: 2718 -----NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVP 2772
N G LVT + A D D G GR+ Y + E G F ++ GE+R
Sbjct: 575 VYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRG-----FFEIDQVNGEVRTTRT 629
Query: 2773 FDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGA 2826
F S+ L+V A D G S S + VL ++L+PA Q G+
Sbjct: 630 FGESSKSSYELIVVAHDHGKTSLSASALVL---------IYLSPALDAQESMGS 674
Score = 194 bits (492), Expect = 2e-48
Identities = 175/637 (27%), Positives = 284/637 (44%), Gaps = 49/637 (7%)
Query: 2076 TIRENAPPGTPI--VSPRAVHAGGTNGP---ITYSILSGNEKGTFSIQPSTGAITVRSAE 2130
++ E GT I V+ A AG P + ++S + I PS+G + +
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKI 87
Query: 2131 GLDF--EVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEG 2188
D SP+ + L+ S + V+ + ++D NDNAP F + E+
Sbjct: 88 DRDLLCRQSPKCIISLEVMSS-SMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGT 146
Query: 2189 PLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTT-------GTITTTAILDREIWA 2241
+ A D D GS G +Y L ++ LF ++ T + LDRE +
Sbjct: 147 RIPLDSAYDPDSGSFGVQTYELTPNE----LFGLEIKTRGDGSRFAELVVEKSLDRETQS 202
Query: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTG 2300
+ A D G P +G+ L++ V D+NDN P + + + V E++ + + ++
Sbjct: 203 HYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNA 262
Query: 2301 NDVDSGPVLWYVLSPSG-----PQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD-G 2354
+D D G V S G ++ F + + G V++TG LD+E+ Y+L + A D G
Sbjct: 263 SDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLG 322
Query: 2355 PHE--GRANLTVLVEDVNDNAPAF---SQSLYQVMLLEHTPPGSAILSVSATDRDSGANG 2409
P+ +TV V D NDN P S + V + E PPG I V +DRDSG NG
Sbjct: 323 PNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNG 382
Query: 2410 HISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVH 2469
+ L F + + TI+ L + ++ ++ARD G P + +
Sbjct: 383 RVQCRLLGNVP-FRLQEYE-SFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFT 440
Query: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR 2529
V + D+ND+ P F+ +Y+V V E+ PG+ LL++ A D D + +V Y I+
Sbjct: 441 VLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN-GSVSYQIVPS---- 495
Query: 2530 VFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVT 2589
Q+ S P G + L + E + V A D G P S V
Sbjct: 496 --QVRDMPVFTYVSINPNS---GDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVR 550
Query: 2590 VTVLDVNDNPPVFT-----RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSG 2644
V +LDVNDN PV T + V +P ++ +G + V+A D D G +G V + ++ G
Sbjct: 551 VIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEG 610
Query: 2645 DPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
D G FE+D+ +G +R +++ ++L+V A D
Sbjct: 611 D-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHD 646
Score = 189 bits (481), Expect = 3e-47
Identities = 176/570 (30%), Positives = 255/570 (44%), Gaps = 55/570 (9%)
Query: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNE 2111
VI V ++ + P FP A E I E A PGT I A G+ G TY L+ NE
Sbjct: 114 VIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYE-LTPNE 172
Query: 2112 KGTFSIQPSTGAITVRSAE-----GLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQD 2163
F ++ T R AE LD E + A GG L++ + D
Sbjct: 173 --LFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTD 230
Query: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA--SQPARGLFH 2221
+NDN P F Y +PE+ P P++++ A D D+G+ GQ+ YS + R LF
Sbjct: 231 SNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQ 290
Query: 2222 VDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP--- 2278
+DP +G +T T LD E L + A D G ++ +TV V+DTNDN P I
Sbjct: 291 IDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLS 350
Query: 2279 -QPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG--RVSLTG 2335
+ VSE A G IA V +D DSG + V PF + Y + + G
Sbjct: 351 VNSELVEVSESAPPGYVIALVRVSDRDSG-LNGRVQCRLLGNVPFRLQEYESFSTILVDG 409
Query: 2336 PLDFEQCDRYQLQLLAHDGPH---EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPG 2392
LD EQ D+Y L + A DG + + TVL+ D NDN P FS+ YQV++ E+ PG
Sbjct: 410 RLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPG 469
Query: 2393 SAILSVSATDRDSGANGHISYHLA------SPADGF-SVDPNNGTLFTIVGTVALGHDGS 2445
+ +LSVSA D D G NG +SY + P + S++PN+G ++ + + H+ +
Sbjct: 470 AYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYAL---RSFNHEQT 526
Query: 2446 GAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPP-----GST 2500
A + + A+D G P + ATV V + D ND+ P T E P G
Sbjct: 527 KAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYL 586
Query: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
+ ++A D D + V Y + G+ G F+++ E + G
Sbjct: 587 VTVVKAEDYD-EGENGRVTYDMTEGDRG-FFEIDQVNGEVRTTRTFGE------------ 632
Query: 2561 DFESLTQYNLTVAAADRGQPPQSSVVPVTV 2590
S + Y L V A D G+ S+ V +
Sbjct: 633 --SSKSSYELIVVAHDHGKTSLSASALVLI 660
Score = 174 bits (442), Expect = 1e-42
Identities = 185/681 (27%), Positives = 291/681 (42%), Gaps = 64/681 (9%)
Query: 1113 AVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQQLSEDSKAF-RIHPQTGEVTTLQTL 1169
+V E Q GT + V R++G + R + + +S + I+P +G + T Q +
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKI 87
Query: 1170 DREQ--QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVP 1227
DR+ + S + ++ ++ S + V + DLNDN+P+F A + +++
Sbjct: 88 DRDLLCRQSPKCIISLEVMSSSMEICV--IKVEIKDLNDNAPSFPAAQ------IELEIS 139
Query: 1228 DRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHS-------GELLTAAPLI 1280
+ PGT + A DPD G G Y LT +ELF L + EL+ L
Sbjct: 140 EAASPGTRIPLDSAYDPDSGSFGVQTYELTP--NELFGLEIKTRGDGSRFAELVVEKSLD 197
Query: 1281 RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340
R + HY ++A D G PPR ++ L ++V S + P +E A VP
Sbjct: 198 RETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN---DNNPVFSESTYAVSVP------ 248
Query: 1341 AAEGLRPGSLLGSVAAPEP--AGVGALTYTLVGGADPEGT--FALDAASGRLYLARPLDF 1396
E P + + + A +P G + Y+ G + F +D SG + + LD+
Sbjct: 249 --ENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
Query: 1397 EAGPPWRALTVRAE--GPGGAGARLLRVQVQVQDENEHAPAF---ARDPLALALPENPEP 1451
E G + L V+A+ GP A +V V V D N++ P + + + + E+ P
Sbjct: 307 EEGHVYE-LDVQAKDLGPNSIPAHC-KVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
Query: 1452 GAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLL 1511
G + R SD D G N V+ RLL P L+ + LDRE L
Sbjct: 365 GYVIALVRVSDRDS-GLNGRVQCRLLGNVPF--RLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 1512 LVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVAR 1570
++A D ++A+ S V +TDENDN P F+ P +V + E+ PG L V AR
Sbjct: 422 TIQARD--GGVPMLQSAK-SFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSAR 478
Query: 1571 DPDLGEAARVSYRLASGGDG------HFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
DPDLG VSY++ + ++ ++G + +R + EQ V+A D
Sbjct: 479 DPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDG 538
Query: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEY-----SVLLRENNPPGTSLLTLRATDPDVG 1679
G P + + V + DVND P V + N+ G + ++A D D G
Sbjct: 539 GLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG 598
Query: 1680 ANGQVTYGGVSSES--FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
NG+VTY + F +D G + T R + L V A D G V
Sbjct: 599 ENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
Query: 1738 RVAVEDENDHAPTFGSAHLSL 1758
+ + D + GS +LSL
Sbjct: 659 LIYLSPALDAQESMGSVNLSL 679
Score = 162 bits (411), Expect = 4e-39
Identities = 131/424 (30%), Positives = 207/424 (48%), Gaps = 44/424 (10%)
Query: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNW 2527
+ V+++D ND+APSF + + ++E PG+ + A D D SG++
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPD-------------SGSF 161
Query: 2528 G-RVFQLEPRLAEAGE--SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSS 2584
G + ++L P E + G G R LV+ + LD E+ + Y+ + A D G PP+
Sbjct: 162 GVQTYELTPNELFGLEIKTRGDGSR-FAELVVEKSLDRETQSHYSFRITALDGGDPPRLG 220
Query: 2585 VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT---V 2641
V +++ V D NDN PVF+ ++Y V+VPE++P ++ + ASD D G +G V ++
Sbjct: 221 TVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGY 280
Query: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVN 2700
+ LF++D SG + + ALD E ++L VQA D A VT+ V D N
Sbjct: 281 VNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTN 340
Query: 2701 DHGPAFPLNLLSTS-----VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGP-GPEG 2754
D+ P +NLLS + V+E+ PPG ++ + D D+G GR++ LL P +
Sbjct: 341 DNPPV--INLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE 398
Query: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPV 2812
E+F+ G L D E + + L + A D G L ++ + +VL+T E++ P
Sbjct: 399 YESFSTILVDGRL------DREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPH 452
Query: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-------PYFGINQTT 2865
F P + V E G L V A D D G +G V Y + S Y IN +
Sbjct: 453 FSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNS 512
Query: 2866 GALY 2869
G +Y
Sbjct: 513 GDIY 516
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 342 bits (876), Expect = 5e-93
Identities = 247/687 (35%), Positives = 356/687 (51%), Gaps = 50/687 (7%)
Query: 21 LLLPLLLLLLLLLGAGVPGAWGQAGSL---DLQIDEEQPAGTLIGDISAGL-PAGTAAPL 76
LLLP+LLLL +L W QA +L ++EEQ AGT+I +++ AG A
Sbjct: 4 LLLPVLLLLAIL--------WTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDP 55
Query: 77 MYFISAQEGSGVGTDLA-IDEHSGVVRTARVLDREQRDRYR------FTAVTPDGATVEV 129
+ + S L I+ SG++ T + +DR+ R ++ +
Sbjct: 56 RQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVI 115
Query: 130 TVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGE 189
V + D+ND+AP+FP A+ L++ E + GTR PL+ A D D+G G Q Y L+ + E
Sbjct: 116 KVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN---E 172
Query: 190 TFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDIN 249
F LE + DG+ ELVV LDRE +SHY ++ A DGG PPR L + + D N
Sbjct: 173 LFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN 232
Query: 250 DHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE----INRRQSEGDGPF 305
D+ P F++S Y V E+ P +PV+++ ASD D G NG V Y +N R E F
Sbjct: 233 DNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRE---LF 289
Query: 306 SIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVI 365
ID H+GL+ + LD+E+ V+EL VQA+D G + VTV V D NDN P + ++
Sbjct: 290 QIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLL 349
Query: 366 FLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVC 425
++++ +VSE+APPG ++A + VSD D G V L G F L +S +
Sbjct: 350 SVNSE-LVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNV-PFRLQEYES-FSTIL 406
Query: 426 VARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEV 485
V RLDRE+ D YNL + A D G P L++ +F + +TD NDN P F + Y+ + E
Sbjct: 407 VDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ-VIVQEN 465
Query: 486 ALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH-----WFSIDPTSGIITTAASLDYEL 540
PG++++ V+ARDPD G NG V+Y + P + SI+P SG I S ++E
Sbjct: 466 NTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQ 525
Query: 541 EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQR-TFYNAS----LPEGTQPGT 595
+ V+A DGGLP L S+ATV V + DVNDN P N + +P + G
Sbjct: 526 TKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGY 585
Query: 596 CFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF 655
V A D D G G ++Y + G F ID +G+V TTRT + SS++
Sbjct: 586 LVTVVKAEDYDEGENGRVTYDMTEG----DRGFFEIDQVNGEVRTTRTFG-ESSKSSYEL 640
Query: 656 TVTAVDGG--GLKSMVYVKVFLSDEND 680
V A D G L + V ++LS D
Sbjct: 641 IVVAHDHGKTSLSASALVLIYLSPALD 667
Score = 212 bits (539), Expect = 6e-54
Identities = 185/676 (27%), Positives = 294/676 (43%), Gaps = 60/676 (8%)
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEG------ENGTILYTLTGPGSELFS 1265
L AA L V + GT++ + AKD E + ++ L
Sbjct: 15 LWTQAAALINLKYSVEEEQRAGTVIANV-AKDAREAGFALDPRQASAFRVVSNSAPHLVD 73
Query: 1266 LHPHSGELLTAAPLIR----AERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPP 1321
++P SG L+T + R + P +++L S+S+++ V + L +
Sbjct: 74 INPSSGLLVTKQKIDRDLLCRQSPKCIISLEV-------MSSSMEICVIKVEIKDLNDNA 126
Query: 1322 PDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
P PAA + + ++ A+ G R L S P+ G TY L P F L
Sbjct: 127 PSF----PAAQIELEISEAASPGTRIP--LDSAYDPDSGSFGVQTYELT----PNELFGL 176
Query: 1382 DAAS-------GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAP 1434
+ + L + + LD E + +G + + ++V D N++ P
Sbjct: 177 EIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNP 236
Query: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLR--QEPPVPALRLDART 1492
F+ A+++PEN P + ASD D G N V Y + ++D +
Sbjct: 237 VFSESTYAVSVPENSPPNTPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQIDPHS 295
Query: 1493 GALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF----AS 1548
G ++ LD E L V+A D N+ A V V D NDN PV +
Sbjct: 296 GLVTVTGALDYEEGHVYELDVQAKDLGPNSI---PAHCKVTVSVLDTNDNPPVINLLSVN 352
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLD 1608
V + E PPG V D D G RV RL + + S + V LD
Sbjct: 353 SELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLD 412
Query: 1609 REQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSL 1668
REQ ++ LT+ A D G P + + TV + D ND P F + Y V+++ENN PG L
Sbjct: 413 REQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL 472
Query: 1669 LTLRATDPDVGANGQVTYGGVSSE--------SFSLDPDTGVLTTLRALDREEQEEINLT 1720
L++ A DPD+G NG V+Y V S+ S++P++G + LR+ + E+ +
Sbjct: 473 LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFK 532
Query: 1721 VYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT------LTMLRA 1774
V A+D G P ++ TVRV + D ND+ P + L E P+ +T+++A
Sbjct: 533 VLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKA 592
Query: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
D D G NG++ Y + +GD G F +D +GE T R + +++L + A D G+ +
Sbjct: 593 EDYDEGENGRVTYDMTEGD-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 1835 LSATLLLTVTVLDAND 1850
LSA+ L+ + + A D
Sbjct: 652 LSASALVLIYLSPALD 667
Score = 211 bits (536), Expect = 1e-53
Identities = 179/619 (28%), Positives = 284/619 (45%), Gaps = 51/619 (8%)
Query: 497 ARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL--EPQPQLIVVATDGG 554
A DP Q + +V + AP H I+P+SG++ T +D +L P+ I+
Sbjct: 52 ALDPRQASAFRVVSNSAP----HLVDINPSSGLLVTKQKIDRDLLCRQSPKCII-----S 102
Query: 555 LPPLASS---ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFG 611
L ++SS + V ++D+NDN P F + E PGT +A D DSG FG
Sbjct: 103 LEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFG 162
Query: 612 LLSYSL------GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGL 665
+ +Y L G + + G + ++ ++LDR+ S + F +TA+DGG
Sbjct: 163 VQTYELTPNELFGLEIKTRGD-----GSRFAELVVEKSLDRET-QSHYSFRITALDGGDP 216
Query: 666 KSM--VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723
+ V + + ++D NDN P F YA S+ SPP T V+RL A DPD+G++G++ Y
Sbjct: 217 PRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYS 276
Query: 724 I---LAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI 780
+ + LF +D SGL+TV L V +L++ A+D G +V +S+
Sbjct: 277 FYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSV 336
Query: 781 VPGTPTPPIFEQLQY---VFSVPEDVAPGTSVGIVQ-AHNPPGRLAPVTLSLSGGDPRGL 836
+ PP+ L + V E PG + +V+ + G V L G P L
Sbjct: 337 LDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL 396
Query: 837 FSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFP 895
++ S +L R LDRE L ++ R G GVP + VL+ D NDN P F
Sbjct: 397 QEYESFSTILVDGR-LDREQHDQYNLTIQARDG-GVPMLQSAKSFTVLITDENDNHPHFS 454
Query: 896 APEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG---GGGAFT---VDPTTGH 949
P V++ N PG + ++ A DPD G+N V++ ++ FT ++P +G
Sbjct: 455 KPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGD 514
Query: 950 VRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRG---LAPRFNSPTYR 1006
+ +R A E ++ A+DGG P S+ +RV++ DV AP + T
Sbjct: 515 IYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAE 574
Query: 1007 VDLPSGTTAGTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDRE 1063
V +P + G V V+A+ D G +TY + EG F ++ +G +
Sbjct: 575 VYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDM-TEGDRGFFEIDQVNGEVRTTRTFGES 633
Query: 1064 AQELYILKVMAVSGSKAEL 1082
++ Y L V+A K L
Sbjct: 634 SKSSYELIVVAHDHGKTSL 652
Score = 209 bits (531), Expect = 5e-53
Identities = 166/603 (27%), Positives = 270/603 (44%), Gaps = 49/603 (8%)
Query: 1696 LDPDTGVLTTLRALDREE--QEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1753
++P +G+L T + +DR+ ++ + + S ++ ++V ++D ND+AP+F +
Sbjct: 74 INPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEIC--VIKVEIKDLNDNAPSFPA 131
Query: 1754 AHLSLEVPEGQDPQTLTML-RASDPDVGANGQLQYRILDGDPSGAFVLDLASG----EFG 1808
A + LE+ E P T L A DPD G+ G Y + + G + G E
Sbjct: 132 AQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELV 191
Query: 1809 TMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDV 1868
+ LDRE + + RI A DGG P T+ L++ V D+ND+ P F Y+V VPE+
Sbjct: 192 VEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENS 251
Query: 1869 PAGTLLLQLQAHDPDAGANGHVTY----YLGAGTAGAFLLEPSSGELRTAAALDREQCPS 1924
P T +++L A DPD G NG V Y Y+ T F ++P SG + ALD E+
Sbjct: 252 PPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHV 311
Query: 1925 YTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLA 1982
Y V A D GP S VT++V D ND+ P + L S + P
Sbjct: 312 YELDVQAKD---LGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSES-APPGYV 367
Query: 1983 LATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV------L 2036
+A +R DRD+G N + RL G P E + + G DR L
Sbjct: 368 IALVRVSDRDSGLNGRVQCRLLGNVP------FRLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 2037 FIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG 2096
I A D G P + V + E + P F + + ++EN PG ++S A
Sbjct: 422 TIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD 481
Query: 2097 -GTNGPITYSILSGNEKGT-----FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG 2150
G NG ++Y I+ + SI P++G + + + E + + A+ GG
Sbjct: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSG--DIYALRSFNHEQTKAFEFKVLAKDGG 539
Query: 2151 AFAF---TVLTLTLQDANDNAPRFLRPHYV-----AFLPESRPLEGPLLQVEADDLDQGS 2202
+ + + + D NDN P P + ++P + + + V+A+D D+G
Sbjct: 540 LPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGE 599
Query: 2203 GGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSAT 2262
G+++Y + ++ RG F +D G + TT + L+++A D G +L SA
Sbjct: 600 NGRVTYDM--TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
Query: 2263 LTV 2265
+ +
Sbjct: 658 VLI 660
Score = 199 bits (507), Expect = 3e-50
Identities = 168/643 (26%), Positives = 274/643 (42%), Gaps = 66/643 (10%)
Query: 709 AHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLAR------RANSVVQLEIGA 762
A DP Q S ++ +++ ++P L ++ SGLL + R ++ LE+ +
Sbjct: 52 ALDPRQAS----AFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMS 107
Query: 763 EDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRL 821
+ + + I P F Q + E +PGT + + A++P G
Sbjct: 108 S------SMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSF 161
Query: 822 APVTLSLSGGDPRGLFSLDAVS-------GLLQTLRPLDRELLGPVLELEVRAGSGVPPA 874
T L+ P LF L+ + L + LDRE G PP
Sbjct: 162 GVQTYELT---PNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPR 218
Query: 875 FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL 934
+ + + D NDN+P F V +P N+ P TP+ L A DPD G N +V ++
Sbjct: 219 LGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFY 278
Query: 935 AGGGGA----FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQD 990
F +DP +G V + L G +EL+++A+D G +H ++ V V D
Sbjct: 279 GYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLD 338
Query: 991 VGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASS------- 1043
N P + + +++++V AP G I ++ S
Sbjct: 339 TND-------NPPVINL-----LSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQC 386
Query: 1044 ------PFGLEPQSGW--LWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI 1095
PF L+ + + V LDRE + Y L + A G L + V I
Sbjct: 387 RLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPML---QSAKSFTVLI 443
Query: 1096 LNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLS-EDSKAF 1154
++N++ P S+ + V EN PG + V A D D G NG ++Y + D F
Sbjct: 444 TDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVF 503
Query: 1155 R---IHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF 1211
I+P +G++ L++ + EQ +++ V +DGG P + TV V +LD+NDN+P
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPV- 562
Query: 1212 LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSG 1271
+ A G + +P G LVT ++A+D DEGENG + Y +T F + +G
Sbjct: 563 ITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNG 622
Query: 1272 ELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPS 1314
E+ T + + Y L + AHD G SAS +L+ + P+
Sbjct: 623 EVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPA 665
Score = 199 bits (506), Expect = 4e-50
Identities = 186/654 (28%), Positives = 282/654 (43%), Gaps = 68/654 (10%)
Query: 2205 QISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLT 2264
Q S S A L ++P++G + T +DR++ + + + + +
Sbjct: 57 QASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIK 116
Query: 2265 VMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDP 2321
V + D NDN P+ P EL +SE A G+ I + D DSG V Y L+P+ +
Sbjct: 117 VEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN---EL 173
Query: 2322 FSV-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVND 2371
F + G + + LD E Y ++ A DG P G L++ V D ND
Sbjct: 174 FGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSND 233
Query: 2372 NAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDP 2426
N P FS+S Y V + E++PP + ++ ++A+D D G NG + Y + F +DP
Sbjct: 234 NNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDP 293
Query: 2427 NNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
++G L T+ G AL ++ ++ ++A+D G A V V + D ND+ P L
Sbjct: 294 HSG-LVTVTG--ALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLS 350
Query: 2487 YR---VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGES 2543
V V+E PPG + + +D D SG GRV + RL
Sbjct: 351 VNSELVEVSESAPPGYVIALVRVSDRD-------------SGLNGRV---QCRLLGNVPF 394
Query: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFT 2603
+ +++ LD E QYNLT+ A D G P S TV + D NDN P F+
Sbjct: 395 RLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFS 454
Query: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGL-----FELDESSGT 2658
+ Y+V V E+ GA LL V A D D G +G V + + + ++ +SG
Sbjct: 455 KPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGD 514
Query: 2659 LRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAE 2717
+ + + E + V A D + A V + + DVND+ P L AE
Sbjct: 515 IYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAE 574
Query: 2718 -----NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVP 2772
N G LVT + A D D G GR+ Y + E G F ++ GE+R
Sbjct: 575 VYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRG-----FFEIDQVNGEVRTTRT 629
Query: 2773 FDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGA 2826
F S+ L+V A D G S S + VL ++L+PA Q G+
Sbjct: 630 FGESSKSSYELIVVAHDHGKTSLSASALVL---------IYLSPALDAQESMGS 674
Score = 194 bits (492), Expect = 2e-48
Identities = 175/637 (27%), Positives = 284/637 (44%), Gaps = 49/637 (7%)
Query: 2076 TIRENAPPGTPI--VSPRAVHAGGTNGP---ITYSILSGNEKGTFSIQPSTGAITVRSAE 2130
++ E GT I V+ A AG P + ++S + I PS+G + +
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKI 87
Query: 2131 GLDF--EVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEG 2188
D SP+ + L+ S + V+ + ++D NDNAP F + E+
Sbjct: 88 DRDLLCRQSPKCIISLEVMSS-SMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGT 146
Query: 2189 PLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTT-------GTITTTAILDREIWA 2241
+ A D D GS G +Y L ++ LF ++ T + LDRE +
Sbjct: 147 RIPLDSAYDPDSGSFGVQTYELTPNE----LFGLEIKTRGDGSRFAELVVEKSLDRETQS 202
Query: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTG 2300
+ A D G P +G+ L++ V D+NDN P + + + V E++ + + ++
Sbjct: 203 HYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNA 262
Query: 2301 NDVDSGPVLWYVLSPSG-----PQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD-G 2354
+D D G V S G ++ F + + G V++TG LD+E+ Y+L + A D G
Sbjct: 263 SDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLG 322
Query: 2355 PHE--GRANLTVLVEDVNDNAPAF---SQSLYQVMLLEHTPPGSAILSVSATDRDSGANG 2409
P+ +TV V D NDN P S + V + E PPG I V +DRDSG NG
Sbjct: 323 PNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNG 382
Query: 2410 HISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVH 2469
+ L F + + TI+ L + ++ ++ARD G P + +
Sbjct: 383 RVQCRLLGNVP-FRLQEYE-SFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFT 440
Query: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR 2529
V + D+ND+ P F+ +Y+V V E+ PG+ LL++ A D D + +V Y I+
Sbjct: 441 VLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN-GSVSYQIVPS---- 495
Query: 2530 VFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVT 2589
Q+ S P G + L + E + V A D G P S V
Sbjct: 496 --QVRDMPVFTYVSINPNS---GDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVR 550
Query: 2590 VTVLDVNDNPPVFT-----RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSG 2644
V +LDVNDN PV T + V +P ++ +G + V+A D D G +G V + ++ G
Sbjct: 551 VIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEG 610
Query: 2645 DPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
D G FE+D+ +G +R +++ ++L+V A D
Sbjct: 611 D-RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHD 646
Score = 189 bits (481), Expect = 3e-47
Identities = 176/570 (30%), Positives = 255/570 (44%), Gaps = 55/570 (9%)
Query: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNE 2111
VI V ++ + P FP A E I E A PGT I A G+ G TY L+ NE
Sbjct: 114 VIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYE-LTPNE 172
Query: 2112 KGTFSIQPSTGAITVRSAE-----GLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQD 2163
F ++ T R AE LD E + A GG L++ + D
Sbjct: 173 --LFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTD 230
Query: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA--SQPARGLFH 2221
+NDN P F Y +PE+ P P++++ A D D+G+ GQ+ YS + R LF
Sbjct: 231 SNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQ 290
Query: 2222 VDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP--- 2278
+DP +G +T T LD E L + A D G ++ +TV V+DTNDN P I
Sbjct: 291 IDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLS 350
Query: 2279 -QPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG--RVSLTG 2335
+ VSE A G IA V +D DSG + V PF + Y + + G
Sbjct: 351 VNSELVEVSESAPPGYVIALVRVSDRDSG-LNGRVQCRLLGNVPFRLQEYESFSTILVDG 409
Query: 2336 PLDFEQCDRYQLQLLAHDGPH---EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPG 2392
LD EQ D+Y L + A DG + + TVL+ D NDN P FS+ YQV++ E+ PG
Sbjct: 410 RLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPG 469
Query: 2393 SAILSVSATDRDSGANGHISYHLA------SPADGF-SVDPNNGTLFTIVGTVALGHDGS 2445
+ +LSVSA D D G NG +SY + P + S++PN+G ++ + + H+ +
Sbjct: 470 AYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYAL---RSFNHEQT 526
Query: 2446 GAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPP-----GST 2500
A + + A+D G P + ATV V + D ND+ P T E P G
Sbjct: 527 KAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYL 586
Query: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
+ ++A D D + V Y + G+ G F+++ E + G
Sbjct: 587 VTVVKAEDYD-EGENGRVTYDMTEGDRG-FFEIDQVNGEVRTTRTFGE------------ 632
Query: 2561 DFESLTQYNLTVAAADRGQPPQSSVVPVTV 2590
S + Y L V A D G+ S+ V +
Sbjct: 633 --SSKSSYELIVVAHDHGKTSLSASALVLI 660
Score = 174 bits (442), Expect = 1e-42
Identities = 185/681 (27%), Positives = 291/681 (42%), Gaps = 64/681 (9%)
Query: 1113 AVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQQLSEDSKAF-RIHPQTGEVTTLQTL 1169
+V E Q GT + V R++G + R + + +S + I+P +G + T Q +
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKI 87
Query: 1170 DREQ--QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVP 1227
DR+ + S + ++ ++ S + V + DLNDN+P+F A + +++
Sbjct: 88 DRDLLCRQSPKCIISLEVMSSSMEICV--IKVEIKDLNDNAPSFPAAQ------IELEIS 139
Query: 1228 DRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHS-------GELLTAAPLI 1280
+ PGT + A DPD G G Y LT +ELF L + EL+ L
Sbjct: 140 EAASPGTRIPLDSAYDPDSGSFGVQTYELTP--NELFGLEIKTRGDGSRFAELVVEKSLD 197
Query: 1281 RAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340
R + HY ++A D G PPR ++ L ++V S + P +E A VP
Sbjct: 198 RETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN---DNNPVFSESTYAVSVP------ 248
Query: 1341 AAEGLRPGSLLGSVAAPEP--AGVGALTYTLVGGADPEGT--FALDAASGRLYLARPLDF 1396
E P + + + A +P G + Y+ G + F +D SG + + LD+
Sbjct: 249 --ENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
Query: 1397 EAGPPWRALTVRAE--GPGGAGARLLRVQVQVQDENEHAPAF---ARDPLALALPENPEP 1451
E G + L V+A+ GP A +V V V D N++ P + + + + E+ P
Sbjct: 307 EEGHVYE-LDVQAKDLGPNSIPAHC-KVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
Query: 1452 GAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLL 1511
G + R SD D G N V+ RLL P L+ + LDRE L
Sbjct: 365 GYVIALVRVSDRDS-GLNGRVQCRLLGNVPF--RLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 1512 LVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVAR 1570
++A D ++A+ S V +TDENDN P F+ P +V + E+ PG L V AR
Sbjct: 422 TIQARD--GGVPMLQSAK-SFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSAR 478
Query: 1571 DPDLGEAARVSYRLASGGDG------HFRLHSSTGALSVVRPLDREQRAEHVLTVVASDH 1624
DPDLG VSY++ + ++ ++G + +R + EQ V+A D
Sbjct: 479 DPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDG 538
Query: 1625 GSPPRSATQVLTVSVADVNDEAPTFQQQEY-----SVLLRENNPPGTSLLTLRATDPDVG 1679
G P + + V + DVND P V + N+ G + ++A D D G
Sbjct: 539 GLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG 598
Query: 1680 ANGQVTYGGVSSES--FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
NG+VTY + F +D G + T R + L V A D G V
Sbjct: 599 ENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
Query: 1738 RVAVEDENDHAPTFGSAHLSL 1758
+ + D + GS +LSL
Sbjct: 659 LIYLSPALDAQESMGSVNLSL 679
Score = 162 bits (411), Expect = 4e-39
Identities = 131/424 (30%), Positives = 207/424 (48%), Gaps = 44/424 (10%)
Query: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNW 2527
+ V+++D ND+APSF + + ++E PG+ + A D D SG++
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPD-------------SGSF 161
Query: 2528 G-RVFQLEPRLAEAGE--SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSS 2584
G + ++L P E + G G R LV+ + LD E+ + Y+ + A D G PP+
Sbjct: 162 GVQTYELTPNELFGLEIKTRGDGSR-FAELVVEKSLDRETQSHYSFRITALDGGDPPRLG 220
Query: 2585 VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT---V 2641
V +++ V D NDN PVF+ ++Y V+VPE++P ++ + ASD D G +G V ++
Sbjct: 221 TVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGY 280
Query: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVN 2700
+ LF++D SG + + ALD E ++L VQA D A VT+ V D N
Sbjct: 281 VNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTN 340
Query: 2701 DHGPAFPLNLLSTS-----VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGP-GPEG 2754
D+ P +NLLS + V+E+ PPG ++ + D D+G GR++ LL P +
Sbjct: 341 DNPPV--INLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE 398
Query: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPV 2812
E+F+ G L D E + + L + A D G L ++ + +VL+T E++ P
Sbjct: 399 YESFSTILVDGRL------DREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPH 452
Query: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-------PYFGINQTT 2865
F P + V E G L V A D D G +G V Y + S Y IN +
Sbjct: 453 FSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNS 512
Query: 2866 GALY 2869
G +Y
Sbjct: 513 GDIY 516
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 330 bits (845), Expect = 2e-89
Identities = 240/721 (33%), Positives = 361/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIGD+ L P + M F + V + I+E +G + T
Sbjct: 30 IREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 88
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 89 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 148
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 149 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 206
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 327 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 384
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 385 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG + +V+A D D G N ++
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKIN 502
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 503 YLLGPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 561
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F YN +PE + GT L +T TD D G ++ S+ +
Sbjct: 562 DQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 615
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 616 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 744 V 744
+
Sbjct: 735 L 735
Score = 272 bits (696), Expect = 4e-72
Identities = 206/665 (30%), Positives = 320/665 (48%), Gaps = 39/665 (5%)
Query: 1418 RLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLL 1477
RL++++ ++D N++AP F + +++PEN + YT A+ G N Y L+
Sbjct: 121 RLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YTLPAAVDPDVGINGVQNYELI 179
Query: 1478 RQEPPVPALRLDARTG----ALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSAR 1533
+ + ++ G L + LDRE ++ V+ D +R++ +
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED---GGFPQRSSTAILQ 236
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR----LASGG 1588
V VTD NDN PVF V +PE+ P G + + A D D+GE A++ + +++
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
F L+++TG +++ PLDRE+ H L V+ASD G P A ++ V+V DVND P+
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPS 354
Query: 1649 FQQQ------EYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP---D 1699
+ +V+L EN P T + + TD D NG+VT F L P +
Sbjct: 355 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLE 1759
+L T LD E +E + + A D G PP + + V+DEND+AP F + +++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 1760 VPEGQDPQ-TLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVE 1818
+PE P LT + A D D G N ++ Y +L D F LD +G ++ LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
+ I A+D G P L++ + + V+++D ND++P F Y+ VPE++P + +
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG 1938
DPD G N VT + F ++ +G +R + DRE+ SYTF V A DG
Sbjct: 594 VTDPDYGDNSAVTLSI-LDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1939 PLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANAS 1998
S++ VTI V DVND+ P F P PS + T+ + A D D G NA
Sbjct: 653 -RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI-AVDNDTGMNAE 710
Query: 1999 ILYRLAGTPPPGTT-----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV 2053
+ Y + G G T +D TG I + + + A DLG+P S V
Sbjct: 711 VRYSIVG----GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP-DSLFSV 765
Query: 2054 IIVGL 2058
+IV L
Sbjct: 766 VIVNL 770
Score = 246 bits (628), Expect = 3e-64
Identities = 217/767 (28%), Positives = 343/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 93
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 94 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 149
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 209
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 210 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269
Query: 1670 TLRATDPDVGANGQVTY------GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 330 SDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 387
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 388 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA-------YLDYESTKEYAIKLLAAD 440
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L ++ A D D+G N
Sbjct: 441 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK 500
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 501 INYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 559
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + +P P T L T D D G N+++ +
Sbjct: 560 IIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 614
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 615 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 735 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 238 bits (608), Expect = 6e-62
Identities = 188/655 (28%), Positives = 299/655 (45%), Gaps = 36/655 (5%)
Query: 1323 DLAERDPAAPVPVV-LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
D+ + P P V+ +++ + L + P+ G Y L+ + G +
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1382 DAASG----RLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFA 1437
+ G +L + + LD E + +G + +QV V D N++ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1438 RDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP--ALRLDARTGAL 1495
+ +++PEN G ++ A+DAD G N+ + + + L+A TG +
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDAD-IGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 1496 SAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP-------VFAS 1548
+ LDRE TP LLV A+D AR V VTD NDN P V
Sbjct: 310 TIKEPLDREETPNHKLLVLASD-----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH---SSTGALSVVR 1605
V L E+ P + D D RV+ + + FRL S+ L
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
LD E E+ + ++A+D G PP + + +L + V D ND AP F Q +V + ENN PG
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L + A D D G N ++ Y G + FSLD TG+LT ++ LDRE++++ T+ A
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGAN 1782
+D G PP ++VTV V++ D+ND++P F + VPE T+ ++ +DPD G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1783 GQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT 1842
+ ILD + F +D +G DRE + ++ ++A DGG+ + S++ +T
Sbjct: 603 SAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1843 VTVLDANDHAPAFPVP----AYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAG 1897
+ V+D ND+ P F VP +Y + +P P GT++ Q+ A D D G N V Y +G
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGN 719
Query: 1898 TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
T F ++ +G + D + V A D L + V V + V +
Sbjct: 720 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 236 bits (601), Expect = 4e-61
Identities = 197/672 (29%), Positives = 306/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 418
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L + A DAD S +A ++Y ++ + F L+ R G L
Sbjct: 479 NSPGIQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR--------------TGML 522
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y VPE+
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIA 700
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 701 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 756
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 757 GQPDSLFSVVIV 768
Score = 230 bits (586), Expect = 2e-59
Identities = 203/702 (28%), Positives = 315/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 366
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L TAA L
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLETAAYL 424
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 425 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 479
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-LDREKEDKYLF 538
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + EN P GT +
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 599 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 713
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI 2268
S+ R LF +D TG IT D R+++ A D G P + S + + +
Sbjct: 714 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 2269 DTNDNRPTIPQPWELRVSEDALL-GSEIAQVTGNDVDSGPVL 2309
+ + T+ + +E + +EIA V+ D +L
Sbjct: 773 NESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKIL 814
Score = 229 bits (583), Expect = 4e-59
Identities = 212/740 (28%), Positives = 326/740 (44%), Gaps = 51/740 (6%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 73 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 190
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 368
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDY 426
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 484
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+ +V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPD-APPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 544 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG 600
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 601 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL-VQVLP 1313
+ G + +LF++ +G + + + + + A+D G P S+ ++ + V
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1314 SARLAEPPPDLAERDPAAPV 1333
S A +L + APV
Sbjct: 775 SVTNATLINELVRKSTEAPV 794
Score = 227 bits (579), Expect = 1e-58
Identities = 198/649 (30%), Positives = 294/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 193
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 194 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 314 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLETAAYLDYE 427
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG +
Sbjct: 428 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSA D DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KLDREKEDKYLFTILAKD 544
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y V E+LP T+ + TD D ++
Sbjct: 545 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNS 603
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 604 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 647
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVF----TRASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF + SY + +P P G + V A D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTG 706
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Score = 198 bits (504), Expect = 6e-50
Identities = 181/695 (26%), Positives = 304/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 196
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 197 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 375
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+T LD E
Sbjct: 376 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTK 430
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 431 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
+D DSG N+++ + L F++D TG + +++ L + + A+D G PP
Sbjct: 491 MDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y +P V + PD G L+
Sbjct: 551 TSN--VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 609 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 665
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 724
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 189 bits (480), Expect = 4e-47
Identities = 190/701 (27%), Positives = 304/701 (43%), Gaps = 88/701 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 128
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 186
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 415
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 416 ------------FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L V A DAD GP+ + + + P F LD +G L
Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGML 522
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N + V E
Sbjct: 523 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 635
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAP----AFHFQVPEGARRGHS 2831
ES+ V A D G +S S + V + D D PVF+ P ++ +P G
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTV 694
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
+ V A D D G + V YS+ + F I+Q TG + L
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 181 bits (458), Expect = 1e-44
Identities = 161/580 (27%), Positives = 251/580 (43%), Gaps = 44/580 (7%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLETAAYLDY 426
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 487 KVSAMDADSGPNAKINYLLG---PDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + + V E P V I+V+DPD
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 600 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLP-EVALP----GSFVVRVTARDPDQGTNGQVTY 510
A ++V DVNDN P F + P E+ LP G+ V +V A D D G N +V Y
Sbjct: 657 AKVTINVVDVNDNKPVF---IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 511 SLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQD 570
S+ G F+ID +G IT D +++V A D G P + SV + +
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVN 769
Query: 571 VNDNEPQFQRTFYNASLPEGTQ----PGTCFLQVTATDAD 606
+ NE T N + + T+ P T V++ +D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (450), Expect = 1e-43
Identities = 165/617 (26%), Positives = 258/617 (41%), Gaps = 46/617 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 249
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 250 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 362
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 419
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L +V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P + V E+ + +T D
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 598 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 2361 NLTVLVEDVNDNAPAF----SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL- 2415
+T+ V DVNDN P F S Y+ ++L T PG+ + V A D D+G N + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2416 -ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 717 GGNTRDLFAIDQETGNI 733
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 330 bits (845), Expect = 2e-89
Identities = 240/721 (33%), Positives = 361/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIGD+ L P + M F + V + I+E +G + T
Sbjct: 30 IREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 88
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 89 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 148
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 149 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 206
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 327 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 384
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 385 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG + +V+A D D G N ++
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKIN 502
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 503 YLLGPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 561
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F YN +PE + GT L +T TD D G ++ S+ +
Sbjct: 562 DQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 615
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 616 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 744 V 744
+
Sbjct: 735 L 735
Score = 272 bits (696), Expect = 4e-72
Identities = 206/665 (30%), Positives = 320/665 (48%), Gaps = 39/665 (5%)
Query: 1418 RLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLL 1477
RL++++ ++D N++AP F + +++PEN + YT A+ G N Y L+
Sbjct: 121 RLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YTLPAAVDPDVGINGVQNYELI 179
Query: 1478 RQEPPVPALRLDARTG----ALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSAR 1533
+ + ++ G L + LDRE ++ V+ D +R++ +
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED---GGFPQRSSTAILQ 236
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR----LASGG 1588
V VTD NDN PVF V +PE+ P G + + A D D+GE A++ + +++
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
F L+++TG +++ PLDRE+ H L V+ASD G P A ++ V+V DVND P+
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPS 354
Query: 1649 FQQQ------EYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP---D 1699
+ +V+L EN P T + + TD D NG+VT F L P +
Sbjct: 355 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLE 1759
+L T LD E +E + + A D G PP + + V+DEND+AP F + +++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 1760 VPEGQDPQ-TLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVE 1818
+PE P LT + A D D G N ++ Y +L D F LD +G ++ LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
+ I A+D G P L++ + + V+++D ND++P F Y+ VPE++P + +
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG 1938
DPD G N VT + F ++ +G +R + DRE+ SYTF V A DG
Sbjct: 594 VTDPDYGDNSAVTLSI-LDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1939 PLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANAS 1998
S++ VTI V DVND+ P F P PS + T+ + A D D G NA
Sbjct: 653 -RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI-AVDNDTGMNAE 710
Query: 1999 ILYRLAGTPPPGTT-----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV 2053
+ Y + G G T +D TG I + + + A DLG+P S V
Sbjct: 711 VRYSIVG----GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP-DSLFSV 765
Query: 2054 IIVGL 2058
+IV L
Sbjct: 766 VIVNL 770
Score = 246 bits (628), Expect = 3e-64
Identities = 217/767 (28%), Positives = 343/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 93
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 94 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 149
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 209
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 210 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269
Query: 1670 TLRATDPDVGANGQVTY------GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 330 SDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 387
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 388 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA-------YLDYESTKEYAIKLLAAD 440
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L ++ A D D+G N
Sbjct: 441 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK 500
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 501 INYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 559
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + +P P T L T D D G N+++ +
Sbjct: 560 IIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 614
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 615 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 735 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 238 bits (608), Expect = 6e-62
Identities = 188/655 (28%), Positives = 299/655 (45%), Gaps = 36/655 (5%)
Query: 1323 DLAERDPAAPVPVV-LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
D+ + P P V+ +++ + L + P+ G Y L+ + G +
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1382 DAASG----RLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFA 1437
+ G +L + + LD E + +G + +QV V D N++ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1438 RDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP--ALRLDARTGAL 1495
+ +++PEN G ++ A+DAD G N+ + + + L+A TG +
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDAD-IGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 1496 SAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP-------VFAS 1548
+ LDRE TP LLV A+D AR V VTD NDN P V
Sbjct: 310 TIKEPLDREETPNHKLLVLASD-----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH---SSTGALSVVR 1605
V L E+ P + D D RV+ + + FRL S+ L
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
LD E E+ + ++A+D G PP + + +L + V D ND AP F Q +V + ENN PG
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L + A D D G N ++ Y G + FSLD TG+LT ++ LDRE++++ T+ A
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGAN 1782
+D G PP ++VTV V++ D+ND++P F + VPE T+ ++ +DPD G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1783 GQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT 1842
+ ILD + F +D +G DRE + ++ ++A DGG+ + S++ +T
Sbjct: 603 SAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1843 VTVLDANDHAPAFPVP----AYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAG 1897
+ V+D ND+ P F VP +Y + +P P GT++ Q+ A D D G N V Y +G
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGN 719
Query: 1898 TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
T F ++ +G + D + V A D L + V V + V +
Sbjct: 720 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 236 bits (601), Expect = 4e-61
Identities = 197/672 (29%), Positives = 306/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 418
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L + A DAD S +A ++Y ++ + F L+ R G L
Sbjct: 479 NSPGIQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR--------------TGML 522
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y VPE+
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIA 700
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 701 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 756
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 757 GQPDSLFSVVIV 768
Score = 230 bits (586), Expect = 2e-59
Identities = 203/702 (28%), Positives = 315/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 366
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L TAA L
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLETAAYL 424
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 425 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 479
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-LDREKEDKYLF 538
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + EN P GT +
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 599 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 713
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI 2268
S+ R LF +D TG IT D R+++ A D G P + S + + +
Sbjct: 714 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 2269 DTNDNRPTIPQPWELRVSEDALL-GSEIAQVTGNDVDSGPVL 2309
+ + T+ + +E + +EIA V+ D +L
Sbjct: 773 NESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKIL 814
Score = 229 bits (583), Expect = 4e-59
Identities = 212/740 (28%), Positives = 326/740 (44%), Gaps = 51/740 (6%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 73 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 190
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 368
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDY 426
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 484
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+ +V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPD-APPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 544 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG 600
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 601 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL-VQVLP 1313
+ G + +LF++ +G + + + + + A+D G P S+ ++ + V
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1314 SARLAEPPPDLAERDPAAPV 1333
S A +L + APV
Sbjct: 775 SVTNATLINELVRKSTEAPV 794
Score = 227 bits (579), Expect = 1e-58
Identities = 198/649 (30%), Positives = 294/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 193
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 194 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 314 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLETAAYLDYE 427
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG +
Sbjct: 428 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSA D DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KLDREKEDKYLFTILAKD 544
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y V E+LP T+ + TD D ++
Sbjct: 545 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNS 603
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 604 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 647
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVF----TRASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF + SY + +P P G + V A D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTG 706
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Score = 198 bits (504), Expect = 6e-50
Identities = 181/695 (26%), Positives = 304/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 196
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 197 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 375
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+T LD E
Sbjct: 376 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTK 430
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 431 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
+D DSG N+++ + L F++D TG + +++ L + + A+D G PP
Sbjct: 491 MDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y +P V + PD G L+
Sbjct: 551 TSN--VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 609 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 665
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 724
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 189 bits (480), Expect = 4e-47
Identities = 190/701 (27%), Positives = 304/701 (43%), Gaps = 88/701 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 128
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 186
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 415
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 416 ------------FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L V A DAD GP+ + + + P F LD +G L
Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGML 522
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N + V E
Sbjct: 523 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 635
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAP----AFHFQVPEGARRGHS 2831
ES+ V A D G +S S + V + D D PVF+ P ++ +P G
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTV 694
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
+ V A D D G + V YS+ + F I+Q TG + L
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 181 bits (458), Expect = 1e-44
Identities = 161/580 (27%), Positives = 251/580 (43%), Gaps = 44/580 (7%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLETAAYLDY 426
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 487 KVSAMDADSGPNAKINYLLG---PDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + + V E P V I+V+DPD
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 600 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLP-EVALP----GSFVVRVTARDPDQGTNGQVTY 510
A ++V DVNDN P F + P E+ LP G+ V +V A D D G N +V Y
Sbjct: 657 AKVTINVVDVNDNKPVF---IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 511 SLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQD 570
S+ G F+ID +G IT D +++V A D G P + SV + +
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVN 769
Query: 571 VNDNEPQFQRTFYNASLPEGTQ----PGTCFLQVTATDAD 606
+ NE T N + + T+ P T V++ +D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (450), Expect = 1e-43
Identities = 165/617 (26%), Positives = 258/617 (41%), Gaps = 46/617 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 249
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 250 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 362
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 419
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L +V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P + V E+ + +T D
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 598 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 2361 NLTVLVEDVNDNAPAF----SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL- 2415
+T+ V DVNDN P F S Y+ ++L T PG+ + V A D D+G N + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2416 -ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 717 GGNTRDLFAIDQETGNI 733
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 330 bits (845), Expect = 2e-89
Identities = 240/721 (33%), Positives = 361/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIGD+ L P + M F + V + I+E +G + T
Sbjct: 30 IREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 88
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 89 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 148
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 149 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 206
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 327 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 384
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 385 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG + +V+A D D G N ++
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKIN 502
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 503 YLLGPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 561
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F YN +PE + GT L +T TD D G ++ S+ +
Sbjct: 562 DQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 615
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 616 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 744 V 744
+
Sbjct: 735 L 735
Score = 272 bits (696), Expect = 4e-72
Identities = 206/665 (30%), Positives = 320/665 (48%), Gaps = 39/665 (5%)
Query: 1418 RLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLL 1477
RL++++ ++D N++AP F + +++PEN + YT A+ G N Y L+
Sbjct: 121 RLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YTLPAAVDPDVGINGVQNYELI 179
Query: 1478 RQEPPVPALRLDARTG----ALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSAR 1533
+ + ++ G L + LDRE ++ V+ D +R++ +
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED---GGFPQRSSTAILQ 236
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR----LASGG 1588
V VTD NDN PVF V +PE+ P G + + A D D+GE A++ + +++
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
F L+++TG +++ PLDRE+ H L V+ASD G P A ++ V+V DVND P+
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPS 354
Query: 1649 FQQQ------EYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP---D 1699
+ +V+L EN P T + + TD D NG+VT F L P +
Sbjct: 355 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLE 1759
+L T LD E +E + + A D G PP + + V+DEND+AP F + +++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 1760 VPEGQDPQ-TLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVE 1818
+PE P LT + A D D G N ++ Y +L D F LD +G ++ LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
+ I A+D G P L++ + + V+++D ND++P F Y+ VPE++P + +
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG 1938
DPD G N VT + F ++ +G +R + DRE+ SYTF V A DG
Sbjct: 594 VTDPDYGDNSAVTLSI-LDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1939 PLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANAS 1998
S++ VTI V DVND+ P F P PS + T+ + A D D G NA
Sbjct: 653 -RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI-AVDNDTGMNAE 710
Query: 1999 ILYRLAGTPPPGTT-----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV 2053
+ Y + G G T +D TG I + + + A DLG+P S V
Sbjct: 711 VRYSIVG----GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP-DSLFSV 765
Query: 2054 IIVGL 2058
+IV L
Sbjct: 766 VIVNL 770
Score = 246 bits (628), Expect = 3e-64
Identities = 217/767 (28%), Positives = 343/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 93
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 94 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 149
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 209
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 210 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269
Query: 1670 TLRATDPDVGANGQVTY------GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 330 SDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 387
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 388 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA-------YLDYESTKEYAIKLLAAD 440
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L ++ A D D+G N
Sbjct: 441 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK 500
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 501 INYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 559
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + +P P T L T D D G N+++ +
Sbjct: 560 IIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 614
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 615 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 735 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 238 bits (608), Expect = 6e-62
Identities = 188/655 (28%), Positives = 299/655 (45%), Gaps = 36/655 (5%)
Query: 1323 DLAERDPAAPVPVV-LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
D+ + P P V+ +++ + L + P+ G Y L+ + G +
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1382 DAASG----RLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFA 1437
+ G +L + + LD E + +G + +QV V D N++ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1438 RDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP--ALRLDARTGAL 1495
+ +++PEN G ++ A+DAD G N+ + + + L+A TG +
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDAD-IGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 1496 SAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP-------VFAS 1548
+ LDRE TP LLV A+D AR V VTD NDN P V
Sbjct: 310 TIKEPLDREETPNHKLLVLASD-----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH---SSTGALSVVR 1605
V L E+ P + D D RV+ + + FRL S+ L
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
LD E E+ + ++A+D G PP + + +L + V D ND AP F Q +V + ENN PG
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L + A D D G N ++ Y G + FSLD TG+LT ++ LDRE++++ T+ A
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGAN 1782
+D G PP ++VTV V++ D+ND++P F + VPE T+ ++ +DPD G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1783 GQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT 1842
+ ILD + F +D +G DRE + ++ ++A DGG+ + S++ +T
Sbjct: 603 SAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1843 VTVLDANDHAPAFPVP----AYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAG 1897
+ V+D ND+ P F VP +Y + +P P GT++ Q+ A D D G N V Y +G
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGN 719
Query: 1898 TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
T F ++ +G + D + V A D L + V V + V +
Sbjct: 720 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 236 bits (601), Expect = 4e-61
Identities = 197/672 (29%), Positives = 306/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 418
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L + A DAD S +A ++Y ++ + F L+ R G L
Sbjct: 479 NSPGIQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR--------------TGML 522
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y VPE+
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIA 700
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 701 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 756
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 757 GQPDSLFSVVIV 768
Score = 230 bits (586), Expect = 2e-59
Identities = 203/702 (28%), Positives = 315/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 366
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L TAA L
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLETAAYL 424
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 425 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 479
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-LDREKEDKYLF 538
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + EN P GT +
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 599 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 713
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI 2268
S+ R LF +D TG IT D R+++ A D G P + S + + +
Sbjct: 714 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 2269 DTNDNRPTIPQPWELRVSEDALL-GSEIAQVTGNDVDSGPVL 2309
+ + T+ + +E + +EIA V+ D +L
Sbjct: 773 NESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKIL 814
Score = 229 bits (583), Expect = 4e-59
Identities = 212/740 (28%), Positives = 326/740 (44%), Gaps = 51/740 (6%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 73 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 190
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 368
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDY 426
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 484
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+ +V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPD-APPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 544 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG 600
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 601 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL-VQVLP 1313
+ G + +LF++ +G + + + + + A+D G P S+ ++ + V
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1314 SARLAEPPPDLAERDPAAPV 1333
S A +L + APV
Sbjct: 775 SVTNATLINELVRKSTEAPV 794
Score = 227 bits (579), Expect = 1e-58
Identities = 198/649 (30%), Positives = 294/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 193
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 194 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 314 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLETAAYLDYE 427
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG +
Sbjct: 428 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSA D DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KLDREKEDKYLFTILAKD 544
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y V E+LP T+ + TD D ++
Sbjct: 545 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNS 603
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 604 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 647
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVF----TRASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF + SY + +P P G + V A D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTG 706
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Score = 198 bits (504), Expect = 6e-50
Identities = 181/695 (26%), Positives = 304/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 196
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 197 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 375
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+T LD E
Sbjct: 376 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTK 430
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 431 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
+D DSG N+++ + L F++D TG + +++ L + + A+D G PP
Sbjct: 491 MDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y +P V + PD G L+
Sbjct: 551 TSN--VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 609 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 665
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 724
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 189 bits (480), Expect = 4e-47
Identities = 190/701 (27%), Positives = 304/701 (43%), Gaps = 88/701 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 128
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 186
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 415
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 416 ------------FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L V A DAD GP+ + + + P F LD +G L
Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGML 522
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N + V E
Sbjct: 523 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 635
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAP----AFHFQVPEGARRGHS 2831
ES+ V A D G +S S + V + D D PVF+ P ++ +P G
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTV 694
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
+ V A D D G + V YS+ + F I+Q TG + L
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 181 bits (458), Expect = 1e-44
Identities = 161/580 (27%), Positives = 251/580 (43%), Gaps = 44/580 (7%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLETAAYLDY 426
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 487 KVSAMDADSGPNAKINYLLG---PDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + + V E P V I+V+DPD
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 600 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLP-EVALP----GSFVVRVTARDPDQGTNGQVTY 510
A ++V DVNDN P F + P E+ LP G+ V +V A D D G N +V Y
Sbjct: 657 AKVTINVVDVNDNKPVF---IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 511 SLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQD 570
S+ G F+ID +G IT D +++V A D G P + SV + +
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVN 769
Query: 571 VNDNEPQFQRTFYNASLPEGTQ----PGTCFLQVTATDAD 606
+ NE T N + + T+ P T V++ +D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (450), Expect = 1e-43
Identities = 165/617 (26%), Positives = 258/617 (41%), Gaps = 46/617 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 249
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 250 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 362
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 419
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L +V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P + V E+ + +T D
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 598 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 2361 NLTVLVEDVNDNAPAF----SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL- 2415
+T+ V DVNDN P F S Y+ ++L T PG+ + V A D D+G N + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2416 -ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 717 GGNTRDLFAIDQETGNI 733
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 330 bits (845), Expect = 2e-89
Identities = 240/721 (33%), Positives = 361/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIGD+ L P + M F + V + I+E +G + T
Sbjct: 30 IREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 88
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 89 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 148
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 149 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 206
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 207 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 266
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 267 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 326
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 327 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 384
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 385 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGK 443
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG + +V+A D D G N ++
Sbjct: 444 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKIN 502
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 503 YLLGPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 561
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F YN +PE + GT L +T TD D G ++ S+ +
Sbjct: 562 DQNDNSPVFTHNEYNFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 615
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 616 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 744 V 744
+
Sbjct: 735 L 735
Score = 272 bits (696), Expect = 4e-72
Identities = 206/665 (30%), Positives = 320/665 (48%), Gaps = 39/665 (5%)
Query: 1418 RLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLL 1477
RL++++ ++D N++AP F + +++PEN + YT A+ G N Y L+
Sbjct: 121 RLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YTLPAAVDPDVGINGVQNYELI 179
Query: 1478 RQEPPVPALRLDARTG----ALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSAR 1533
+ + ++ G L + LDRE ++ V+ D +R++ +
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED---GGFPQRSSTAILQ 236
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR----LASGG 1588
V VTD NDN PVF V +PE+ P G + + A D D+GE A++ + +++
Sbjct: 237 VSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIA 296
Query: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
F L+++TG +++ PLDRE+ H L V+ASD G P A ++ V+V DVND P+
Sbjct: 297 RRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPS 354
Query: 1649 FQQQ------EYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP---D 1699
+ +V+L EN P T + + TD D NG+VT F L P +
Sbjct: 355 IDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN 414
Query: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLE 1759
+L T LD E +E + + A D G PP + + V+DEND+AP F + +++
Sbjct: 415 QFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 1760 VPEGQDPQ-TLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVE 1818
+PE P LT + A D D G N ++ Y +L D F LD +G ++ LDRE E
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE 533
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
+ I A+D G P L++ + + V+++D ND++P F Y+ VPE++P + +
Sbjct: 534 DKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG 1938
DPD G N VT + F ++ +G +R + DRE+ SYTF V A DG
Sbjct: 594 VTDPDYGDNSAVTLSI-LDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Query: 1939 PLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANAS 1998
S++ VTI V DVND+ P F P PS + T+ + A D D G NA
Sbjct: 653 -RSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI-AVDNDTGMNAE 710
Query: 1999 ILYRLAGTPPPGTT-----VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV 2053
+ Y + G G T +D TG I + + + A DLG+P S V
Sbjct: 711 VRYSIVG----GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP-DSLFSV 765
Query: 2054 IIVGL 2058
+IV L
Sbjct: 766 VIVNL 770
Score = 246 bits (628), Expect = 3e-64
Identities = 217/767 (28%), Positives = 343/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 93
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 94 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 149
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 150 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 209
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 210 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 269
Query: 1670 TLRATDPDVGANGQVTY------GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 270 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 329
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 330 SDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 387
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 388 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAA-------YLDYESTKEYAIKLLAAD 440
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L ++ A D D+G N
Sbjct: 441 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAK 500
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 501 INYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 559
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + +P P T L T D D G N+++ +
Sbjct: 560 IIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 614
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 615 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 674
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 675 VPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 734
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 735 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 779
Score = 238 bits (608), Expect = 6e-62
Identities = 188/655 (28%), Positives = 299/655 (45%), Gaps = 36/655 (5%)
Query: 1323 DLAERDPAAPVPVV-LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
D+ + P P V+ +++ + L + P+ G Y L+ + G +
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1382 DAASG----RLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFA 1437
+ G +L + + LD E + +G + +QV V D N++ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 1438 RDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP--ALRLDARTGAL 1495
+ +++PEN G ++ A+DAD G N+ + + + L+A TG +
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDAD-IGENAKIHFSFSNLVSNIARRLFHLNATTGLI 309
Query: 1496 SAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP-------VFAS 1548
+ LDRE TP LLV A+D AR V VTD NDN P V
Sbjct: 310 TIKEPLDREETPNHKLLVLASD-----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 1549 PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH---SSTGALSVVR 1605
V L E+ P + D D RV+ + + FRL S+ L
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAA 422
Query: 1606 PLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG 1665
LD E E+ + ++A+D G PP + + +L + V D ND AP F Q +V + ENN PG
Sbjct: 423 YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG 482
Query: 1666 TSLLTLRATDPDVGANGQVTY--GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L + A D D G N ++ Y G + FSLD TG+LT ++ LDRE++++ T+ A
Sbjct: 483 IQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILA 542
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGAN 1782
+D G PP ++VTV V++ D+ND++P F + VPE T+ ++ +DPD G N
Sbjct: 543 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 602
Query: 1783 GQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT 1842
+ ILD + F +D +G DRE + ++ ++A DGG+ + S++ +T
Sbjct: 603 SAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT 660
Query: 1843 VTVLDANDHAPAFPVP----AYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAG 1897
+ V+D ND+ P F VP +Y + +P P GT++ Q+ A D D G N V Y +G
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIVGGN 719
Query: 1898 TAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
T F ++ +G + D + V A D L + V V + V +
Sbjct: 720 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Score = 236 bits (601), Expect = 4e-61
Identities = 197/672 (29%), Positives = 306/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 120 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 179
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 180 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 239
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 240 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 299
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 300 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 359
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 418
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 419 ETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 478
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L + A DAD S +A ++Y ++ + F L+ R G L
Sbjct: 479 NSPGIQLTKVSAMDAD-SGPNAKINY-LLGPDAPPEFSLDCR--------------TGML 522
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y VPE+
Sbjct: 523 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 640
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIA 700
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 701 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 756
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 757 GQPDSLFSVVIV 768
Score = 230 bits (586), Expect = 2e-59
Identities = 203/702 (28%), Positives = 315/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 366
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L TAA L
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLETAAYL 424
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 425 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 479
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-LDREKEDKYLF 538
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + EN P GT +
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 599 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 654
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 713
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI 2268
S+ R LF +D TG IT D R+++ A D G P + S + + +
Sbjct: 714 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 772
Query: 2269 DTNDNRPTIPQPWELRVSEDALL-GSEIAQVTGNDVDSGPVL 2309
+ + T+ + +E + +EIA V+ D +L
Sbjct: 773 NESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKIL 814
Score = 229 bits (583), Expect = 4e-59
Identities = 212/740 (28%), Positives = 326/740 (44%), Gaps = 51/740 (6%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 73 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 132
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 190
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 250
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 251 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 310
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 311 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 368
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLETAAYLDY 426
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 484
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+ +V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPD-APPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 544 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG 600
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 601 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 714
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL-VQVLP 1313
+ G + +LF++ +G + + + + + A+D G P S+ ++ + V
Sbjct: 715 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNE 774
Query: 1314 SARLAEPPPDLAERDPAAPV 1333
S A +L + APV
Sbjct: 775 SVTNATLINELVRKSTEAPV 794
Score = 227 bits (579), Expect = 1e-58
Identities = 198/649 (30%), Positives = 294/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 193
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 194 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 253
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 314 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 371
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 372 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLETAAYLDYE 427
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG +
Sbjct: 428 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTK 487
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSA D DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 488 VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KLDREKEDKYLFTILAKD 544
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y V E+LP T+ + TD D ++
Sbjct: 545 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG-DNS 603
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 604 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 647
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVF----TRASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF + SY + +P P G + V A D D G
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTG 706
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 755
Score = 198 bits (504), Expect = 6e-50
Identities = 181/695 (26%), Positives = 304/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 196
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 197 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 315
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 375
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+T LD E
Sbjct: 376 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTK 430
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 431 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSA 490
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
+D DSG N+++ + L F++D TG + +++ L + + A+D G PP
Sbjct: 491 MDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y +P V + PD G L+
Sbjct: 551 TSN--VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 608
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 609 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 665
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 724
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 725 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759
Score = 189 bits (480), Expect = 4e-47
Identities = 190/701 (27%), Positives = 304/701 (43%), Gaps = 88/701 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 128
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 186
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 364
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 415
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 416 ------------FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 463
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L V A DAD GP+ + + + P F LD +G L
Sbjct: 464 PVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE-FSLDCRTGML 522
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N + V E
Sbjct: 523 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPE 581
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 582 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 635
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAP----AFHFQVPEGARRGHS 2831
ES+ V A D G +S S + V + D D PVF+ P ++ +P G
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLP-STNPGTV 694
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
+ V A D D G + V YS+ + F I+Q TG + L
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 181 bits (458), Expect = 1e-44
Identities = 161/580 (27%), Positives = 251/580 (43%), Gaps = 44/580 (7%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 254 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 373
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 374 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLETAAYLDY 426
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 487 KVSAMDADSGPNAKINYLLG---PDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + + V E P V I+V+DPD
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 600 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 656
Query: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLP-EVALP----GSFVVRVTARDPDQGTNGQVTY 510
A ++V DVNDN P F + P E+ LP G+ V +V A D D G N +V Y
Sbjct: 657 AKVTINVVDVNDNKPVF---IVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 511 SLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQD 570
S+ G F+ID +G IT D +++V A D G P + SV + +
Sbjct: 714 SIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVN 769
Query: 571 VNDNEPQFQRTFYNASLPEGTQ----PGTCFLQVTATDAD 606
+ NE T N + + T+ P T V++ +D
Sbjct: 770 LFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 177 bits (450), Expect = 1e-43
Identities = 165/617 (26%), Positives = 258/617 (41%), Gaps = 46/617 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 131 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 190
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 191 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 249
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 250 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 305
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 306 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 362
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 363 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 419
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L +V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P + V E+ + +T D
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 598 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 2361 NLTVLVEDVNDNAPAF----SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL- 2415
+T+ V DVNDN P F S Y+ ++L T PG+ + V A D D+G N + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 2416 -ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 717 GGNTRDLFAIDQETGNI 733
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 327 bits (838), Expect = 1e-88
Identities = 239/721 (33%), Positives = 362/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIG++ L P + M F + V + I+E +G + T
Sbjct: 62 IREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 120
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 121 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 180
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 181 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 238
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 359 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 416
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 417 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 475
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG +++V+A D D G N ++
Sbjct: 476 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEIN 534
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 535 YLLGPDAPPE-FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 593
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F Y +PE + GT L +T TD D G ++ S+ +
Sbjct: 594 DQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 647
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 648 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 706
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Y S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 766
Query: 744 V 744
+
Sbjct: 767 L 767
Score = 248 bits (632), Expect = 9e-65
Identities = 217/767 (28%), Positives = 345/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 66 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 125
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 126 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 181
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 182 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 241
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 242 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301
Query: 1670 TLRATDPDVGANGQVTYG------GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 362 SDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 419
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 420 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY-------LDYESTKEYAIKLLAAD 472
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L+++ A D D+G N
Sbjct: 473 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE 532
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 533 INYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 591
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + + +P P T L T D D G N+++ +
Sbjct: 592 IIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 646
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 647 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 706
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 766
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 767 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Score = 242 bits (617), Expect = 5e-63
Identities = 198/672 (29%), Positives = 309/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 450
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L+ + ATDAD S +A ++Y ++ + F L+ R G L
Sbjct: 511 NSPGIQLMKVSATDAD-SGPNAEINY-LLGPDAPPEFSLD--------------RRTGML 554
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y+ VPE+
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 614
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 615 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 733 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 788
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 789 GQPDSLFSVVIV 800
Score = 231 bits (588), Expect = 1e-59
Identities = 199/649 (30%), Positives = 296/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 225
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 226 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 285
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 346 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 404 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLENAAYLDYE 459
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG ++
Sbjct: 460 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 519
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSATD DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 520 VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KLDREKEDKYLFTILAKD 576
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y+ V E+LP T+ + TD D ++
Sbjct: 577 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG-DNS 635
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 636 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 679
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVFT----RASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF SY + +P P G + V A D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTG 738
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 787
Score = 228 bits (582), Expect = 6e-59
Identities = 203/702 (28%), Positives = 313/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 398
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L AA L
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLENAAYL 456
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 457 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 511
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-LDREKEDKYLF 570
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + + EN P GT +
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 631 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 686
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 687 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 745
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-ALVGSATLTVMV 2267
S+ R LF +D TG IT D R+++ A D G P +L + + V
Sbjct: 746 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVL 2309
++ N I + + +EIA V+ D +L
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKIL 846
Score = 227 bits (578), Expect = 2e-58
Identities = 204/705 (28%), Positives = 313/705 (44%), Gaps = 50/705 (7%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 105 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 164
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 222
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 223 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 282
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 283 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 342
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 343 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 400
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 401 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDY 458
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 516
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+++V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 517 LMKVSATDADSGPNAEINYLLGPD-APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 576 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 632
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 633 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 746
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP 1299
+ G + +LF++ +G + + + + + A+D G P
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 207 bits (528), Expect = 1e-52
Identities = 214/751 (28%), Positives = 319/751 (42%), Gaps = 97/751 (12%)
Query: 1136 PNGRLTYSLQ----QLSEDSKAFRIHPQTGEV-TTLQTLDREQQSS---------YQLLV 1181
PN LT ++Q + D RI TGE+ TT +DRE+ + Y++ V
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEV 144
Query: 1182 QVQDGGSPPRSTTGTVHVAVL--DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
+ P V + L D+NDN+P F + I +P+ + T
Sbjct: 145 AIL-----PDEIFRLVKIRFLIEDINDNAPLFPATV------INISIPENSAINSKYTLP 193
Query: 1240 QAKDPDEGENGTILYTLTGPGSELFSLH-------PHSGELLTAAPLIRAERPHYVLTLS 1292
A DPD G NG Y L +F L +L+ L R E+ YV+ +
Sbjct: 194 AAVDPDVGINGVQNYELI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 1293 AHDQGSPPRSASLQLLVQVL------PSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLR 1346
D G P RS++ L V V P + E + E P L T A+
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDAD--- 309
Query: 1347 PGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALT 1406
E A + LV F L+A +G + + PLD E P + L
Sbjct: 310 ---------IGENAKIHFSFSNLVSNI-ARRLFHLNATTGLITIKEPLDREETPNHKLLV 359
Query: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAF--------ARDPLALA--LPENPEPGAALY 1456
+ ++G G AR + V V V D N++ P+ D + L+ +P N + AL
Sbjct: 360 LASDG-GLMPARAM-VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK--IALI 415
Query: 1457 TFRASDADGPG-----PNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL-- 1509
T DAD G + ++ +RL PV + + A LD E+T
Sbjct: 416 TVTDKDADHNGRVTCFTDHEIPFRLR----PVFSNQFLLENAAY-----LDYESTKEYAI 466
Query: 1510 -LLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAALHV 1567
LL +A P N S +V DENDNAPVF S V +PE+ PG + V
Sbjct: 467 KLLAADAGKPPLNQSAMLFIKVK------DENDNAPVFTQSFVTVSIPENNSPGIQLMKV 520
Query: 1568 VARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSP 1627
A D D G A ++Y L F L TG L+VV+ LDRE+ +++ T++A D+G P
Sbjct: 521 SATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 580
Query: 1628 PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG 1687
P ++ + VS+ D ND +P F EY + EN P ++ + TDPD G N VT
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 1688 GV-SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
+ ++ F++D TGV+ + DRE+QE V A+D G + + V + V D ND
Sbjct: 641 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVND 700
Query: 1747 HAPTF----GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
+ P F + L +P + + A D D G N +++Y I+ G+ F +D
Sbjct: 701 NKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 760
Query: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
+G M D ++ ++A D GQP
Sbjct: 761 ETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 196 bits (498), Expect = 3e-49
Identities = 180/695 (25%), Positives = 302/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 111 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 170
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 228
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 229 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 407
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+ LD E
Sbjct: 408 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTK 462
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 463 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSA 522
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
D DSG N+ + + L F++D TG + +++ L + + A+D G PP
Sbjct: 523 TDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y+ +P V + PD G L+
Sbjct: 583 TSN--VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 641 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 697
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 698 VNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 756
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 757 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 195 bits (495), Expect = 7e-49
Identities = 190/700 (27%), Positives = 305/700 (43%), Gaps = 86/700 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 106 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 160
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 218
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 219 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 447
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 448 ------------FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L+ V A+DAD GP+ + + + P F LD +G L
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGML 554
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N V E
Sbjct: 555 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 614 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 667
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQ---VPEGARRGHSL 2832
ES+ V A D G +S S + V + D D PVF+ P +++ V G +
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 727
Query: 2833 GHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
V A D D G + V YS+ + F I+Q TG + L
Sbjct: 728 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 181 bits (460), Expect = 8e-45
Identities = 160/577 (27%), Positives = 248/577 (42%), Gaps = 38/577 (6%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLENAAYLDY 458
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A+DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 519 KVSATDADSGPNAEINYLLG---PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + V E P V I+V+DPD
Sbjct: 576 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 456 AAFVLHVTDVNDNAPAF--DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA 513
A ++V DVNDN P F Y E + PG+ V +V A D D G N +V YS+
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748
Query: 514 PGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVND 573
G F+ID +G IT D +++V A D G P + SV + ++
Sbjct: 749 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVNLFV 804
Query: 574 NEPQFQRTFYN----ASLPEGTQPGTCFLQVTATDAD 606
NE T N S+ P T V++ +D
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 181 bits (459), Expect = 1e-44
Identities = 169/668 (25%), Positives = 281/668 (42%), Gaps = 57/668 (8%)
Query: 875 FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL 934
F + ++R L++D+NDN+P FPA + +P N+A + A+DPD G+N + L+
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 935 AGGG--GAFTVDPTTG----HVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVV 988
G ++ G + + + L + ++++ DGG P R+S L+V V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITY------HLAAEGAS 1042
D T P F V +P GT V Q+ A D G +L + A
Sbjct: 272 TD--TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329
Query: 1043 SPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHS 1102
F L +G + ++ LDRE + L V+A G G A V V++ + N++
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDG-----GLMPARAMVLVNVTDVNDNV 384
Query: 1103 P----RLSEDPT--FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRI 1156
P R +P + ++EN P T + + TD+D+ NGR+T ++ FR+
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC----FTDHEIPFRL 440
Query: 1157 HPQTGEVTTLQT---LDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
P L+ LD E Y + + D G PP + + + + V D NDN+P F Q
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 500
Query: 1214 ASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
+ + + +P+ PG + + A D D G N I Y L FSL +G L
Sbjct: 501 SF------VTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 554
Query: 1274 LTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPV 1333
L R + Y+ T+ A D G PP ++++ + V ++ + P + V
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQ---NDNSPVFTHNEYKFYV 611
Query: 1334 PVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARP 1393
P L GL +V P+ A+T +++ D F +D+ +G +
Sbjct: 612 PENLPRHGTVGLI------TVTDPDYGDNSAVTLSIL---DENDDFTIDSQTGVIRPNIS 662
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP----LALALPENP 1449
D E + +G + + +V + V D N++ P F P L LP +
Sbjct: 663 FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-ST 721
Query: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL 1509
PG ++ A D D G N++VRY ++ +D TG ++ D
Sbjct: 722 NPGTVVFQVIAVDND-TGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLH 779
Query: 1510 LLLVEATD 1517
+LV+A D
Sbjct: 780 RVLVKAND 787
Score = 181 bits (459), Expect = 1e-44
Identities = 164/616 (26%), Positives = 258/616 (41%), Gaps = 44/616 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 163 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 222
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 223 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 281
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 282 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 337
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 338 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 394
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 395 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 451
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L++V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 569
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P ++ V E+ + +T D
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 630 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 2361 NLTVLVEDVNDNAPAFSQSLYQV---MLLEHTPPGSAILSVSATDRDSGANGHISYHL-- 2415
+T+ V DVNDN P F Y ++L T PG+ + V A D D+G N + Y +
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749
Query: 2416 ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 750 GNTRDLFAIDQETGNI 765
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 327 bits (838), Expect = 1e-88
Identities = 239/721 (33%), Positives = 362/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIG++ L P + M F + V + I+E +G + T
Sbjct: 62 IREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 120
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 121 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 180
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 181 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 238
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 359 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 416
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 417 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 475
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG +++V+A D D G N ++
Sbjct: 476 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEIN 534
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 535 YLLGPDAPPE-FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 593
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F Y +PE + GT L +T TD D G ++ S+ +
Sbjct: 594 DQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 647
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 648 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 706
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Y S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 766
Query: 744 V 744
+
Sbjct: 767 L 767
Score = 248 bits (632), Expect = 9e-65
Identities = 217/767 (28%), Positives = 345/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 66 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 125
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 126 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 181
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 182 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 241
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 242 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 301
Query: 1670 TLRATDPDVGANGQVTYG------GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 302 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 362 SDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 419
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 420 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY-------LDYESTKEYAIKLLAAD 472
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L+++ A D D+G N
Sbjct: 473 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE 532
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 533 INYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 591
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + + +P P T L T D D G N+++ +
Sbjct: 592 IIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 646
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 647 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 706
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 766
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 767 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Score = 242 bits (617), Expect = 5e-63
Identities = 198/672 (29%), Positives = 309/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 272 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 331
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 332 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 391
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 450
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L+ + ATDAD S +A ++Y ++ + F L+ R G L
Sbjct: 511 NSPGIQLMKVSATDAD-SGPNAEINY-LLGPDAPPEFSLD--------------RRTGML 554
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y+ VPE+
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 614
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 615 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 733 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 788
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 789 GQPDSLFSVVIV 800
Score = 231 bits (588), Expect = 1e-59
Identities = 199/649 (30%), Positives = 296/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 225
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 226 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 285
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 346 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 403
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 404 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLENAAYLDYE 459
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG ++
Sbjct: 460 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 519
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSATD DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 520 VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KLDREKEDKYLFTILAKD 576
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y+ V E+LP T+ + TD D ++
Sbjct: 577 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG-DNS 635
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 636 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 679
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVFT----RASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF SY + +P P G + V A D D G
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTG 738
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 787
Score = 228 bits (582), Expect = 6e-59
Identities = 203/702 (28%), Positives = 313/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 398
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L AA L
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLENAAYL 456
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 457 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 511
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-LDREKEDKYLF 570
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + + EN P GT +
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 631 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 686
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 687 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 745
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-ALVGSATLTVMV 2267
S+ R LF +D TG IT D R+++ A D G P +L + + V
Sbjct: 746 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 804
Query: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVL 2309
++ N I + + +EIA V+ D +L
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKIL 846
Score = 227 bits (578), Expect = 2e-58
Identities = 204/705 (28%), Positives = 313/705 (44%), Gaps = 50/705 (7%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 105 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 164
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 222
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 223 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 282
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 283 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 342
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 343 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 400
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 401 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDY 458
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 516
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+++V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 517 LMKVSATDADSGPNAEINYLLGPD-APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 576 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 632
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 633 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 746
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP 1299
+ G + +LF++ +G + + + + + A+D G P
Sbjct: 747 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 207 bits (528), Expect = 1e-52
Identities = 214/751 (28%), Positives = 319/751 (42%), Gaps = 97/751 (12%)
Query: 1136 PNGRLTYSLQ----QLSEDSKAFRIHPQTGEV-TTLQTLDREQQSS---------YQLLV 1181
PN LT ++Q + D RI TGE+ TT +DRE+ + Y++ V
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEV 144
Query: 1182 QVQDGGSPPRSTTGTVHVAVL--DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
+ P V + L D+NDN+P F + I +P+ + T
Sbjct: 145 AIL-----PDEIFRLVKIRFLIEDINDNAPLFPATV------INISIPENSAINSKYTLP 193
Query: 1240 QAKDPDEGENGTILYTLTGPGSELFSLH-------PHSGELLTAAPLIRAERPHYVLTLS 1292
A DPD G NG Y L +F L +L+ L R E+ YV+ +
Sbjct: 194 AAVDPDVGINGVQNYELI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 1293 AHDQGSPPRSASLQLLVQVL------PSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLR 1346
D G P RS++ L V V P + E + E P L T A+
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDAD--- 309
Query: 1347 PGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALT 1406
E A + LV F L+A +G + + PLD E P + L
Sbjct: 310 ---------IGENAKIHFSFSNLVSNI-ARRLFHLNATTGLITIKEPLDREETPNHKLLV 359
Query: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAF--------ARDPLALA--LPENPEPGAALY 1456
+ ++G G AR + V V V D N++ P+ D + L+ +P N + AL
Sbjct: 360 LASDG-GLMPARAM-VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK--IALI 415
Query: 1457 TFRASDADGPG-----PNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL-- 1509
T DAD G + ++ +RL PV + + A LD E+T
Sbjct: 416 TVTDKDADHNGRVTCFTDHEIPFRLR----PVFSNQFLLENAAY-----LDYESTKEYAI 466
Query: 1510 -LLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAALHV 1567
LL +A P N S +V DENDNAPVF S V +PE+ PG + V
Sbjct: 467 KLLAADAGKPPLNQSAMLFIKVK------DENDNAPVFTQSFVTVSIPENNSPGIQLMKV 520
Query: 1568 VARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSP 1627
A D D G A ++Y L F L TG L+VV+ LDRE+ +++ T++A D+G P
Sbjct: 521 SATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 580
Query: 1628 PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG 1687
P ++ + VS+ D ND +P F EY + EN P ++ + TDPD G N VT
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 1688 GV-SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
+ ++ F++D TGV+ + DRE+QE V A+D G + + V + V D ND
Sbjct: 641 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVND 700
Query: 1747 HAPTF----GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
+ P F + L +P + + A D D G N +++Y I+ G+ F +D
Sbjct: 701 NKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 760
Query: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
+G M D ++ ++A D GQP
Sbjct: 761 ETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 196 bits (498), Expect = 3e-49
Identities = 180/695 (25%), Positives = 302/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 111 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 170
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 228
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 229 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 347
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 407
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+ LD E
Sbjct: 408 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTK 462
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 463 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSA 522
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
D DSG N+ + + L F++D TG + +++ L + + A+D G PP
Sbjct: 523 TDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y+ +P V + PD G L+
Sbjct: 583 TSN--VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 641 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 697
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 698 VNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 756
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 757 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 195 bits (495), Expect = 7e-49
Identities = 190/700 (27%), Positives = 305/700 (43%), Gaps = 86/700 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 106 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 160
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 218
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 219 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 447
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 448 ------------FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L+ V A+DAD GP+ + + + P F LD +G L
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGML 554
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N V E
Sbjct: 555 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 614 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 667
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQ---VPEGARRGHSL 2832
ES+ V A D G +S S + V + D D PVF+ P +++ V G +
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 727
Query: 2833 GHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
V A D D G + V YS+ + F I+Q TG + L
Sbjct: 728 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 181 bits (460), Expect = 8e-45
Identities = 160/577 (27%), Positives = 248/577 (42%), Gaps = 38/577 (6%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 286 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 346 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLENAAYLDY 458
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A+DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 519 KVSATDADSGPNAEINYLLG---PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 575
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + V E P V I+V+DPD
Sbjct: 576 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 688
Query: 456 AAFVLHVTDVNDNAPAF--DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA 513
A ++V DVNDN P F Y E + PG+ V +V A D D G N +V YS+
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748
Query: 514 PGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVND 573
G F+ID +G IT D +++V A D G P + SV + ++
Sbjct: 749 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVNLFV 804
Query: 574 NEPQFQRTFYN----ASLPEGTQPGTCFLQVTATDAD 606
NE T N S+ P T V++ +D
Sbjct: 805 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 181 bits (459), Expect = 1e-44
Identities = 169/668 (25%), Positives = 281/668 (42%), Gaps = 57/668 (8%)
Query: 875 FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL 934
F + ++R L++D+NDN+P FPA + +P N+A + A+DPD G+N + L+
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 935 AGGG--GAFTVDPTTG----HVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVV 988
G ++ G + + + L + ++++ DGG P R+S L+V V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 271
Query: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITY------HLAAEGAS 1042
D T P F V +P GT V Q+ A D G +L + A
Sbjct: 272 TD--TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329
Query: 1043 SPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHS 1102
F L +G + ++ LDRE + L V+A G G A V V++ + N++
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDG-----GLMPARAMVLVNVTDVNDNV 384
Query: 1103 P----RLSEDPT--FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRI 1156
P R +P + ++EN P T + + TD+D+ NGR+T ++ FR+
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC----FTDHEIPFRL 440
Query: 1157 HPQTGEVTTLQT---LDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
P L+ LD E Y + + D G PP + + + + V D NDN+P F Q
Sbjct: 441 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 500
Query: 1214 ASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
+ + + +P+ PG + + A D D G N I Y L FSL +G L
Sbjct: 501 SF------VTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 554
Query: 1274 LTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPV 1333
L R + Y+ T+ A D G PP ++++ + V ++ + P + V
Sbjct: 555 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQ---NDNSPVFTHNEYKFYV 611
Query: 1334 PVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARP 1393
P L GL +V P+ A+T +++ D F +D+ +G +
Sbjct: 612 PENLPRHGTVGLI------TVTDPDYGDNSAVTLSIL---DENDDFTIDSQTGVIRPNIS 662
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP----LALALPENP 1449
D E + +G + + +V + V D N++ P F P L LP +
Sbjct: 663 FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-ST 721
Query: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL 1509
PG ++ A D D G N++VRY ++ +D TG ++ D
Sbjct: 722 NPGTVVFQVIAVDND-TGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLH 779
Query: 1510 LLLVEATD 1517
+LV+A D
Sbjct: 780 RVLVKAND 787
Score = 181 bits (459), Expect = 1e-44
Identities = 164/616 (26%), Positives = 258/616 (41%), Gaps = 44/616 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 163 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 222
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 223 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 281
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 282 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 337
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 338 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 394
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 395 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 451
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L++V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 569
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P ++ V E+ + +T D
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 630 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 2361 NLTVLVEDVNDNAPAFSQSLYQV---MLLEHTPPGSAILSVSATDRDSGANGHISYHL-- 2415
+T+ V DVNDN P F Y ++L T PG+ + V A D D+G N + Y +
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749
Query: 2416 ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 750 GNTRDLFAIDQETGNI 765
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 327 bits (838), Expect = 1e-88
Identities = 239/721 (33%), Positives = 362/721 (50%), Gaps = 42/721 (5%)
Query: 51 IDEEQPAGTLIGDISAGL-----PAGTAAPLMYFISAQEGSGVGTDLAIDEHSG-VVRTA 104
I EE P LIG++ L P + M F + V + I+E +G + T
Sbjct: 51 IREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPL-IRIEEDTGEIFTTG 109
Query: 105 RVLDREQ------RDRYRF----TAVTPDGATVEVTVR--VADINDHAPAFPQARAALQV 152
+DRE+ RD + F A+ PD V +R + DIND+AP FP + +
Sbjct: 110 ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI 169
Query: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212
PE++A ++Y L A D D G G Q Y L + F L+ P+G +P+L+V E
Sbjct: 170 PENSAINSKYTLPAAVDPDVGINGVQNYELIK--SQNIFGLDVIETPEGDKMPQLIVQKE 227
Query: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272
LDRE + Y+++++ DGG P R + A+L V++ D ND+ P F ++ + E+ G+
Sbjct: 228 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 287
Query: 273 PVLQVFASDADAGVNGAVTYEINRRQSE-GDGPFSIDAHTGLLQLERPLDFEQRRVHELV 331
V Q+ A+DAD G N + + + S F ++A TGL+ ++ PLD E+ H+L+
Sbjct: 288 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 347
Query: 332 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFL--SADGSPQVSEAAPPGQLVARIS 389
V A DGG P A V V+V D NDN PS+ + ++ + + +SE P +A I+
Sbjct: 348 VLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALIT 405
Query: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGS 449
V+D D V + E F L S +L+ A LD E Y +++ A D+G
Sbjct: 406 VTDKDADHNGRVTCFTD-HEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGK 464
Query: 450 PPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT 509
PPL A + V D NDNAP F Q + +PE PG +++V+A D D G N ++
Sbjct: 465 PPLNQSAMLFIKVKDENDNAPVF-TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEIN 523
Query: 510 YSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Y L P A FS+D +G++T LD E E + ++A D G+PPL S+ TV V++
Sbjct: 524 YLLGPDAPPE-FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII 582
Query: 570 DVNDNEPQFQRTFYNASLPEG-TQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
D NDN P F Y +PE + GT L +T TD D G ++ S+ +
Sbjct: 583 DQNDNSPVFTHNEYKFYVPENLPRHGTVGL-ITVTDPDYGDNSAVTLSI-----LDENDD 636
Query: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPPQFY 686
F ID+ +G + + DR++ S+ F V A DGG + KV ++ D NDN P F
Sbjct: 637 FTIDSQTGVIRPNISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 695
Query: 687 PREYAASISAQSP---PGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Y S P PGT V ++ A D D G + + Y I+ GN+ LF +D+++G +T
Sbjct: 696 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 755
Query: 744 V 744
+
Sbjct: 756 L 756
Score = 248 bits (632), Expect = 9e-65
Identities = 217/767 (28%), Positives = 345/767 (44%), Gaps = 64/767 (8%)
Query: 1445 LPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGAL-SAPRGLDR 1503
+PEN G L S + ++++L+ + VP +R++ TG + + +DR
Sbjct: 55 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDR 114
Query: 1504 ETTPA-------LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-ASPSRVRLP 1555
E A VE P R V R + D NDNAP+F A+ + +P
Sbjct: 115 EKLCAGIPRDEHCFYEVEVAILPDEIFRL----VKIRFLIEDINDNAPLFPATVINISIP 170
Query: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGGD--GHFRLHSSTG----ALSVVRPLDR 1609
E+ A DPD+G +Y L + G + + G L V + LDR
Sbjct: 171 ENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDR 230
Query: 1610 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL 1669
E++ +V+ V D G P RS+T +L VSV D ND P F++ E V + EN P GTS+
Sbjct: 231 EEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVT 290
Query: 1670 TLRATDPDVGANGQVTYG------GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYA 1723
L ATD D+G N ++ + ++ F L+ TG++T LDREE L V A
Sbjct: 291 QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 350
Query: 1724 QDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL------SLEVPEGQDPQT-LTMLRASD 1776
D G P V V V D ND+ P+ ++ ++ + E T + ++ +D
Sbjct: 351 SDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTD 408
Query: 1777 PDVGANGQLQYRILDGDP-------SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829
D NG++ P S F+L+ A+ LD E + +++ A D
Sbjct: 409 KDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAY-------LDYESTKEYAIKLLAAD 461
Query: 1830 GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH 1889
G+P L+ + +L + V D ND+AP F +V +PE+ G L+++ A D D+G N
Sbjct: 462 AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAE 521
Query: 1890 VTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949
+ Y LG F L+ +G L LDRE+ Y F++ A D PL++ V+V ++
Sbjct: 522 INYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVS 580
Query: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPP 2009
+ D ND++P F + + +P P T L T D D G N+++ +
Sbjct: 581 IIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVT----DPDYGDNSAVTLSIL-DEND 635
Query: 2010 GTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF- 2068
T+DS TG IR S ++ A D GR +RS++ + + + + P F
Sbjct: 636 DFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFI 695
Query: 2069 --PRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQPSTGAIT 2125
P S + + PGT + AV + G N + YSI+ GN + F+I TG IT
Sbjct: 696 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNIT 755
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGG----AFAFTVLTLTLQDANDNA 2168
+ E D R++++A G F+ ++ L + ++ NA
Sbjct: 756 L--MEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 800
Score = 242 bits (617), Expect = 5e-63
Identities = 198/672 (29%), Positives = 309/672 (45%), Gaps = 44/672 (6%)
Query: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
F + ++D NDNAP F +PE+ + A D D G G +Y L
Sbjct: 141 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 200
Query: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETR----LVLMATDRGSPALVGSATLTVMV 2267
SQ GL ++ G I+ +E+ E + + + D G P +A L V V
Sbjct: 201 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 260
Query: 2268 IDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSG-----PQDP 2321
DTNDN P + E+ + E+A +G+ + Q+ D D G S S +
Sbjct: 261 TDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRL 320
Query: 2322 FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP-HEGRANLTVLVEDVNDNAPAFSQSL 2380
F + G +++ PLD E+ ++L +LA DG RA + V V DVNDN P+
Sbjct: 321 FHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRY 380
Query: 2381 Y------QVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTI 2434
V+L E+ P + I ++ TD+D+ NG ++ F + P F +
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLL 439
Query: 2435 VGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTED 2494
L ++ + + L A D G P A + ++++D+ND+AP FT S V++ E+
Sbjct: 440 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 2495 LPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL 2554
PG L+ + ATDAD S +A ++Y ++ + F L+ R G L
Sbjct: 500 NSPGIQLMKVSATDAD-SGPNAEINY-LLGPDAPPEFSLD--------------RRTGML 543
Query: 2555 VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
+++ LD E +Y T+ A D G PP +S V V V+++D NDN PVFT Y+ VPE+
Sbjct: 544 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPEN 603
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
P + + +D D G + V T+S D + F +D +G +R + D E Q +
Sbjct: 604 LPRHGTVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 661
Query: 2675 LVVQAADPAG-AHFALAPVTIEVQDVNDHGPAF---PLNLLSTSVAENQPPGTLVTTLHA 2730
V+A D + + A VTI V DVND+ P F P N V + PGT+V + A
Sbjct: 662 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 721
Query: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
+D D G +RYS++ G R+ FA++ TG + D R+LV A D
Sbjct: 722 VDNDTGMNAEVRYSIV----GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDL 777
Query: 2791 GNLSASVTVSVL 2802
G + +V ++
Sbjct: 778 GQPDSLFSVVIV 789
Score = 231 bits (588), Expect = 1e-59
Identities = 199/649 (30%), Positives = 296/649 (45%), Gaps = 57/649 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSIL-SGNEKGTFSIQPS 2120
+ P FP +I EN+ + P AV G NG Y ++ S N G I+
Sbjct: 155 DNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETP 214
Query: 2121 TGAITVRSA--EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPH 2175
G + + LD E + ++ E GG + +L +++ D NDN P F
Sbjct: 215 EGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETE 274
Query: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA--ASQPARGLFHVDPTTGTITTTA 2233
+PE+ P+ + Q+ A D D G +I +S + S AR LFH++ TTG IT
Sbjct: 275 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334
Query: 2234 ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI-------PQPWELRVS 2286
LDRE +L+++A+D G + A + V V D NDN P+I P + +S
Sbjct: 335 PLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLS 392
Query: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL---TGPLDFE 2340
E+ L ++IA +T D D+ G V + + + PF + L LD+E
Sbjct: 393 ENIPLNTKIALITVTDKDADHNGRVTCF----TDHEIPFRLRPVFSNQFLLENAAYLDYE 448
Query: 2341 QCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397
Y ++LLA D P A L + V+D NDNAP F+QS V + E+ PG ++
Sbjct: 449 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 508
Query: 2398 VSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
VSATD DSG N I+Y L A FS+D G L + L + + A+D
Sbjct: 509 VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KLDREKEDKYLFTILAKD 565
Query: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHA 2516
+G P + TV V + DQND++P FT + Y+ V E+LP T+ + TD D ++
Sbjct: 566 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG-DNS 624
Query: 2517 AVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD 2576
AV SI+ N + + S D E Y V A D
Sbjct: 625 AVTLSILDENDDFTIDSQTGVIRPNIS----------------FDREKQESYTFYVKAED 668
Query: 2577 RGQPPQSSVVPVTVTVLDVNDNPPVFT----RASYRVTVPEDTPVGAELLHVEASDADPG 2632
G+ +SS VT+ V+DVNDN PVF SY + +P P G + V A D D G
Sbjct: 669 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTG 727
Query: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD 2681
+ VR+++ G+ LF +D+ +G + L D H+++V+A D
Sbjct: 728 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKAND 776
Score = 228 bits (582), Expect = 6e-59
Identities = 203/702 (28%), Positives = 313/702 (44%), Gaps = 47/702 (6%)
Query: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES-FSLD 1697
+ D+ND AP F ++ + EN+ + A DPDVG NG Y + S++ F LD
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 1698 ----PDTGVLTTL---RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750
P+ + L + LDREE++ + V +D G P + + ++V+V D ND+ P
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 269
Query: 1751 FGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQY---RILDGDPSGAFVLDLASGE 1806
F + + +PE T +T L A+D D+G N ++ + ++ F L+ +G
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 329
Query: 1807 FGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY------ 1860
PLDRE P +L + A DGG A +L+ VT D ND+ P+ +
Sbjct: 330 ITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVND 387
Query: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAAL 1917
+V + E++P T + + D DA NG VT + F L P L AA L
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP--FRLRPVFSNQFLLENAAYL 445
Query: 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFS 1977
D E Y + A D A PL+ + + I V+D ND+AP F S + + +P +
Sbjct: 446 DYESTKEYAIKLLAAD-AGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN----N 500
Query: 1978 TPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLF 2037
+P + L + A D D+G NA I Y L PP ++D TG + V + + D+ LF
Sbjct: 501 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-LDREKEDKYLF 559
Query: 2038 -IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GTPIVSPRAVHA 2095
I+A D G P ++ + V + + + P F + + EN P GT +
Sbjct: 560 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 619
Query: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT 2155
G N +T SIL N+ F+I TG I R D E ++AE GG + +
Sbjct: 620 YGDNSAVTLSILDENDD--FTIDSQTGVI--RPNISFDREKQESYTFYVKAEDGGRVSRS 675
Query: 2156 V---LTLTLQDANDNAPRFLRP----HYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
+T+ + D NDN P F+ P Y LP + P + QV A D D G ++ Y
Sbjct: 676 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRY 734
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-ALVGSATLTVMV 2267
S+ R LF +D TG IT D R+++ A D G P +L + + V
Sbjct: 735 SIVGGN-TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 793
Query: 2268 IDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVL 2309
++ N I + + +EIA V+ D +L
Sbjct: 794 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKIL 835
Score = 227 bits (578), Expect = 2e-58
Identities = 204/705 (28%), Positives = 313/705 (44%), Gaps = 50/705 (7%)
Query: 627 PPFRIDAHSGDVCTTRT-LDRDQ-------GPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678
P RI+ +G++ TT +DR++ F A+ + +V ++ + D
Sbjct: 94 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDI 153
Query: 679 NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLD-- 736
NDN P F SI S + A DPD G +G +Y ++ S +F LD
Sbjct: 154 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLDVI 211
Query: 737 -----EQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFE 791
++ L V L R +++ EDGG Q +A + +S+ P+F+
Sbjct: 212 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFK 271
Query: 792 QLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG---GDPRGLFSLDAVSGLLQ 847
+ + S+PE+ GTSV + A + G A + S S R LF L+A +GL+
Sbjct: 272 ETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT 331
Query: 848 TLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAP------EDTV 901
PLDRE L + + G+ PA A+ V V DVNDN P+ DTV
Sbjct: 332 IKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVT--DVNDNVPSIDIRYIVNPVNDTV 389
Query: 902 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRP---LGP 958
+L N T I + D D+ N RVT F + P + L+ L
Sbjct: 390 VLSENIPLNTKIALITVTDKDADHNGRVT--CFTDHEIPFRLRPVFSNQFLLENAAYLDY 447
Query: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1018
+ ++L A D G PP L + V+D AP F V +P + G Q
Sbjct: 448 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDN--APVFTQSFVTVSIPENNSPGIQ 505
Query: 1019 VLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075
+++V A D GP I Y L + A F L+ ++G L V LDRE ++ Y+ ++A
Sbjct: 506 LMKVSATDADSGPNAEINYLLGPD-APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 564
Query: 1076 SGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG 1135
L T TV VSI++QN++SP + + V EN P +VG + TD D G
Sbjct: 565 DNGVPPL---TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYG 621
Query: 1136 PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG 1195
N +T S+ ++D F I QTG + + DRE+Q SY V+ +DGG RS++
Sbjct: 622 DNSAVTLSILDENDD---FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 678
Query: 1196 TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT 1255
V + V+D+NDN P F+ L V PGT+V + A D D G N + Y+
Sbjct: 679 KVTINVVDVNDNKPVFIVPPYNYSYEL---VLPSTNPGTVVFQVIAVDNDTGMNAEVRYS 735
Query: 1256 LTGPGS-ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP 1299
+ G + +LF++ +G + + + + + A+D G P
Sbjct: 736 IVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780
Score = 207 bits (528), Expect = 1e-52
Identities = 214/751 (28%), Positives = 319/751 (42%), Gaps = 97/751 (12%)
Query: 1136 PNGRLTYSLQ----QLSEDSKAFRIHPQTGEV-TTLQTLDREQQSS---------YQLLV 1181
PN LT ++Q + D RI TGE+ TT +DRE+ + Y++ V
Sbjct: 74 PNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEV 133
Query: 1182 QVQDGGSPPRSTTGTVHVAVL--DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
+ P V + L D+NDN+P F + I +P+ + T
Sbjct: 134 AIL-----PDEIFRLVKIRFLIEDINDNAPLFPATV------INISIPENSAINSKYTLP 182
Query: 1240 QAKDPDEGENGTILYTLTGPGSELFSLH-------PHSGELLTAAPLIRAERPHYVLTLS 1292
A DPD G NG Y L +F L +L+ L R E+ YV+ +
Sbjct: 183 AAVDPDVGINGVQNYELI-KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 241
Query: 1293 AHDQGSPPRSASLQLLVQVL------PSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLR 1346
D G P RS++ L V V P + E + E P L T A+
Sbjct: 242 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDAD--- 298
Query: 1347 PGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALT 1406
E A + LV F L+A +G + + PLD E P + L
Sbjct: 299 ---------IGENAKIHFSFSNLVSNI-ARRLFHLNATTGLITIKEPLDREETPNHKLLV 348
Query: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAF--------ARDPLALA--LPENPEPGAALY 1456
+ ++G G AR + V V V D N++ P+ D + L+ +P N + AL
Sbjct: 349 LASDG-GLMPARAM-VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK--IALI 404
Query: 1457 TFRASDADGPG-----PNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL-- 1509
T DAD G + ++ +RL PV + + A LD E+T
Sbjct: 405 TVTDKDADHNGRVTCFTDHEIPFRLR----PVFSNQFLLENAAY-----LDYESTKEYAI 455
Query: 1510 -LLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAALHV 1567
LL +A P N S +V DENDNAPVF S V +PE+ PG + V
Sbjct: 456 KLLAADAGKPPLNQSAMLFIKVK------DENDNAPVFTQSFVTVSIPENNSPGIQLMKV 509
Query: 1568 VARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSP 1627
A D D G A ++Y L F L TG L+VV+ LDRE+ +++ T++A D+G P
Sbjct: 510 SATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 569
Query: 1628 PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG 1687
P ++ + VS+ D ND +P F EY + EN P ++ + TDPD G N VT
Sbjct: 570 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 629
Query: 1688 GV-SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDEND 1746
+ ++ F++D TGV+ + DRE+QE V A+D G + + V + V D ND
Sbjct: 630 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVND 689
Query: 1747 HAPTF----GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDL 1802
+ P F + L +P + + A D D G N +++Y I+ G+ F +D
Sbjct: 690 NKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQ 749
Query: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
+G M D ++ ++A D GQP
Sbjct: 750 ETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780
Score = 196 bits (498), Expect = 3e-49
Identities = 180/695 (25%), Positives = 302/695 (43%), Gaps = 43/695 (6%)
Query: 524 DPTSGIITTAASLDYELE----PQPQLIVVATDGGLPP--LASSATVSVALQDVNDNEPQ 577
+ T I TT A +D E P+ + + + P + + ++D+NDN P
Sbjct: 100 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 159
Query: 578 FQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGD 637
F T N S+PE + + + A D D G G+ +Y L G I+ GD
Sbjct: 160 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--IETPEGD 217
Query: 638 ----VCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYA 691
+ + LDR++ ++ V DGG S ++V ++D NDN P F E
Sbjct: 218 KMPQLIVQKELDREE-KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 276
Query: 692 ASISAQSPPGTAVLRLRAHDPDQGSHGRLSY---HILAGNSPPLFTLDEQSGLLTVAWPL 748
SI +P GT+V +L A D D G + ++ + ++++ + LF L+ +GL+T+ PL
Sbjct: 277 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 336
Query: 749 ARRANSVVQLEIGAEDGGGLQAEPSARVDISIV----PGTPTPPIFEQLQYVFSVPEDVA 804
R +L + A DGG + A V+++ V P I + + E++
Sbjct: 337 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIP 396
Query: 805 PGTSVGIVQA------HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
T + ++ HN GR VT P L + + LL+ LD E
Sbjct: 397 LNTKIALITVTDKDADHN--GR---VTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTK 451
Query: 859 PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918
+ A +G PP A + + + D NDN+P F TV +P N +PG + + A
Sbjct: 452 EYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSA 511
Query: 919 LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978
D DSG N+ + + L F++D TG + +++ L + + A+D G PP
Sbjct: 512 TDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 571
Query: 979 TSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLA 1037
TS+ + V V + +P F Y+ +P V + PD G L+
Sbjct: 572 TSN--VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 629
Query: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097
+ F ++ Q+G + + DRE QE Y V A G + ++ +A V +++++
Sbjct: 630 ILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV---SRSSSAKVTINVVD 686
Query: 1098 QNEHSPRLSEDP---TFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
N++ P P ++ V + PGT V +V A D D+G N + YS+ F
Sbjct: 687 VNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG-GNTRDLF 745
Query: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP 1189
I +TG +T ++ D +++LV+ D G P
Sbjct: 746 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780
Score = 195 bits (495), Expect = 7e-49
Identities = 190/700 (27%), Positives = 305/700 (43%), Gaps = 86/700 (12%)
Query: 2219 LFHVDPTTGTITTT-AILDRE-----------IWAETRLVLMATDRGSPALVGSATLTVM 2266
L ++ TG I TT A +DRE + E + ++ + + + +
Sbjct: 95 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDE-----IFRLVKIRFL 149
Query: 2267 VIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFS 2323
+ D NDN P P + + E++ + S+ D D G V Y L S Q+ F
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS--QNIFG 207
Query: 2324 V-------GRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDNA 2373
+ G ++ + LD E+ D Y +++ DG R++ +L V D NDN
Sbjct: 208 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 267
Query: 2374 PAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFS--VDPNNGTL 2431
P F ++ +V + E+ P G+++ + ATD D G N I + ++ + + N T
Sbjct: 268 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 327
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHY---- 2487
I L + + +++ A D G ARA V V + D ND+ PS + +
Sbjct: 328 GLITIKEPLDREETPNHKLLVLASDGGL--MPARAMVLVNVTDVNDNVPSIDIRYIVNPV 385
Query: 2488 --RVAVTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
V ++E++P + + + TD D R D+ I F+L P +
Sbjct: 386 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-------PFRLRPVFSNQ-- 436
Query: 2543 SAGPGPRALGCLVLLEP---LDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNP 2599
LLE LD+ES +Y + + AAD G+PP + + + V D NDN
Sbjct: 437 ------------FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484
Query: 2600 PVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL 2659
PVFT++ V++PE+ G +L+ V A+DAD GP+ + + + P F LD +G L
Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGML 543
Query: 2660 RLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAE 2717
+ LD E + ++ + A D G + VT+ V D ND+ P F N V E
Sbjct: 544 TVVKKLDREKEDKYLFTILAKD-NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 602
Query: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777
N P V + D D G + S+L+ + F ++S TG +R + FD E
Sbjct: 603 NLPRHGTVGLITVTDPDYGDNSAVTLSILDE------NDDFTIDSQTGVIRPNISFDREK 656
Query: 2778 TESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQ---VPEGARRGHSL 2832
ES+ V A D G +S S + V + D D PVF+ P +++ V G +
Sbjct: 657 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVV 716
Query: 2833 GHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYL 2870
V A D D G + V YS+ + F I+Q TG + L
Sbjct: 717 FQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 756
Score = 181 bits (460), Expect = 8e-45
Identities = 160/577 (27%), Positives = 248/577 (42%), Gaps = 38/577 (6%)
Query: 47 LDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
+++ I E P GT + + A G A + + S + ++ +G++
Sbjct: 275 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334
Query: 106 VLDREQRDRYRFTAVTPDG----ATVEVTVRVADINDHAPAFP------QARAALQVPEH 155
LDRE+ ++ + DG A V V V D+ND+ P+ + + E+
Sbjct: 335 PLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 394
Query: 156 TAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDR 215
T+ L D DA G + FRL P + L LD
Sbjct: 395 IPLNTKIALITVTDKDADHNGRVTCFTDHE---IPFRLR----PVFSNQFLLENAAYLDY 447
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ Y ++L A D G PP A+L + + D ND+AP F QS + E+ +PG ++
Sbjct: 448 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR 335
+V A+DAD+G N + Y + + FS+D TG+L + + LD E+ + + A+
Sbjct: 508 KVSATDADSGPNAEINYLLG---PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 564
Query: 336 DGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD 395
D G P + V V + D NDN P +F + V E P V I+V+DPD
Sbjct: 565 DNGVPPLTSNVTVFVSIIDQNDNSP----VFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620
Query: 396 GDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
GD + V +S+ F + +Q VI DRE++++Y V A D G +
Sbjct: 621 GDNSAVTLSILDENDDFTIDSQTGVIRPNI---SFDREKQESYTFYVKAEDGGRVSRSSS 677
Query: 456 AAFVLHVTDVNDNAPAF--DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA 513
A ++V DVNDN P F Y E + PG+ V +V A D D G N +V YS+
Sbjct: 678 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 737
Query: 514 PGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVND 573
G F+ID +G IT D +++V A D G P + SV + ++
Sbjct: 738 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP----DSLFSVVIVNLFV 793
Query: 574 NEPQFQRTFYN----ASLPEGTQPGTCFLQVTATDAD 606
NE T N S+ P T V++ +D
Sbjct: 794 NESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 181 bits (459), Expect = 1e-44
Identities = 169/668 (25%), Positives = 281/668 (42%), Gaps = 57/668 (8%)
Query: 875 FAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL 934
F + ++R L++D+NDN+P FPA + +P N+A + A+DPD G+N + L+
Sbjct: 141 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 200
Query: 935 AGGG--GAFTVDPTTG----HVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVV 988
G ++ G + + + L + ++++ DGG P R+S L+V V
Sbjct: 201 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSV 260
Query: 989 QDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITY------HLAAEGAS 1042
D T P F V +P GT V Q+ A D G +L + A
Sbjct: 261 TD--TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 318
Query: 1043 SPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHS 1102
F L +G + ++ LDRE + L V+A G G A V V++ + N++
Sbjct: 319 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDG-----GLMPARAMVLVNVTDVNDNV 373
Query: 1103 P----RLSEDPT--FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRI 1156
P R +P + ++EN P T + + TD+D+ NGR+T ++ FR+
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC----FTDHEIPFRL 429
Query: 1157 HPQTGEVTTLQT---LDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQ 1213
P L+ LD E Y + + D G PP + + + + V D NDN+P F Q
Sbjct: 430 RPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQ 489
Query: 1214 ASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL 1273
+ + + +P+ PG + + A D D G N I Y L FSL +G L
Sbjct: 490 SF------VTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGML 543
Query: 1274 LTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPV 1333
L R + Y+ T+ A D G PP ++++ + V ++ + P + V
Sbjct: 544 TVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQ---NDNSPVFTHNEYKFYV 600
Query: 1334 PVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARP 1393
P L GL +V P+ A+T +++ D F +D+ +G +
Sbjct: 601 PENLPRHGTVGLI------TVTDPDYGDNSAVTLSIL---DENDDFTIDSQTGVIRPNIS 651
Query: 1394 LDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDP----LALALPENP 1449
D E + +G + + +V + V D N++ P F P L LP +
Sbjct: 652 FDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP-ST 710
Query: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPAL 1509
PG ++ A D D G N++VRY ++ +D TG ++ D
Sbjct: 711 NPGTVVFQVIAVDND-TGMNAEVRYSIVGGNTR-DLFAIDQETGNITLMEKCDVTDLGLH 768
Query: 1510 LLLVEATD 1517
+LV+A D
Sbjct: 769 RVLVKAND 776
Score = 181 bits (459), Expect = 1e-44
Identities = 164/616 (26%), Positives = 258/616 (41%), Gaps = 44/616 (7%)
Query: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTAGAFLL 1904
D ND+AP FP ++ +PE+ + A DPD G NG Y L G ++
Sbjct: 152 DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVI 211
Query: 1905 EPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
E G+ L LDRE+ +Y V DG ST + + ++V D ND+ P F
Sbjct: 212 ETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVF 270
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSY 2016
+ + + +P P ++ T L A D D G NA I + + +++
Sbjct: 271 KETEIEVSIPENAPVGTSVT----QLHATDADIGENAKIHFSFSNLVSNIARRLFHLNAT 326
Query: 2017 TGEIRVARSPVALGPRDRVLFIVATDLG-RPARSATGVIIVGLQGEAERGPRFP------ 2069
TG I + + L ++A+D G PAR+ +++V + + P
Sbjct: 327 TGLITIKEPLDREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVN 383
Query: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGT-NGPITYSILSGNEKGTFSIQPS-TGAITVR 2127
+ + EN P T I NG +T + + F ++P + +
Sbjct: 384 PVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRPVFSNQFLLE 440
Query: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+A LD+E + + L A G +L + ++D NDNAP F + +PE+
Sbjct: 441 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 500
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
L++V A D D G +I+Y L P F +D TG +T LDRE +
Sbjct: 501 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 558
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDV 2303
++A D G P L + T+ V +ID NDN P ++ V E+ + +T D
Sbjct: 559 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 618
Query: 2304 DSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---A 2360
D G LS D F++ G + D E+ + Y + A DG R A
Sbjct: 619 DYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 678
Query: 2361 NLTVLVEDVNDNAPAFSQSLYQV---MLLEHTPPGSAILSVSATDRDSGANGHISYHL-- 2415
+T+ V DVNDN P F Y ++L T PG+ + V A D D+G N + Y +
Sbjct: 679 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 738
Query: 2416 ASPADGFSVDPNNGTL 2431
+ D F++D G +
Sbjct: 739 GNTRDLFAIDQETGNI 754
>gi|94538350 protocadherin 17 precursor [Homo sapiens]
Length = 1159
Score = 322 bits (824), Expect = 5e-87
Identities = 230/690 (33%), Positives = 333/690 (48%), Gaps = 62/690 (8%)
Query: 46 SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTD-------------- 91
+L+ + EEQ AGT+IG+I G A L + E G G
Sbjct: 20 NLNYSVPEEQGAGTVIGNI------GRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPH 73
Query: 92 -LAIDEHSGVVRTARVLDREQRDRYR------FTAVTPDGATVEVTVRVADINDHAPAFP 144
L +D SG++ T + +DRE R+ D + V + DIND+AP+F
Sbjct: 74 LLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFS 133
Query: 145 QARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPV 204
+ + + E+ A GTR+PL A D DAG G + Y L+ D G F L+ + DGT
Sbjct: 134 SDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHG-LFGLDVKSRGDGTKF 192
Query: 205 PELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVV 264
PELV+ LDRE ++H+ L L A DGG PPR A ++V ++D ND++P F Y +
Sbjct: 193 PELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVEL 252
Query: 265 SESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP-FSIDAHTGLLQLERPLDFE 323
E+ G+ V+ + A+DAD G NG V Y + + FSID TGL++++ LD+E
Sbjct: 253 PENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYE 312
Query: 324 QRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQ 383
+ + E+ VQARD G +P VTV + D NDN PS+ + + +SEAAPPG
Sbjct: 313 ENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA---LSEAAPPGT 369
Query: 384 LVARISVSDPDDGDFAHVNVSLEGGEG--------------HFALSTQDSVIYLVCVARR 429
++A + V+D D G + + GG G F L Y V R
Sbjct: 370 VIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRP 429
Query: 430 LDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPG 489
LDRE +D YN+ + A D GSPPL + +F + + D NDN P F + LY + + E +PG
Sbjct: 430 LDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQ-VHENNIPG 488
Query: 490 SFVVRVTARDPDQGTNGQVTYSLAPG-----AHTHWFSIDPTSGIITTAASLDYELEPQP 544
++ V A+DPD G NG V+YS+ P + + S++PT+G I S ++E
Sbjct: 489 EYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAF 548
Query: 545 QLIVVATDGGLPP-LASSATVSVALQDVNDNE-----PQFQRTFYNASLPEGTQPGTCFL 598
+ V+A D G P L S+ATV V + DVNDN P Q +P G
Sbjct: 549 EFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVS 608
Query: 599 QVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVT 658
V A D+D G G L+Y + G + F ID SG++ T D P + V
Sbjct: 609 TVRALDSDFGESGRLTYEIVDG---NDDHLFEIDPSSGEIRTLHPFWEDVTP-VVELVVK 664
Query: 659 AVDGGGLKSMVYVKVFLSDENDNPPQFYPR 688
D G K+ + + + P+ PR
Sbjct: 665 VTDHGKPTLSAVAKLIIRSVSGSLPEGVPR 694
Score = 270 bits (691), Expect = 1e-71
Identities = 226/712 (31%), Positives = 322/712 (45%), Gaps = 96/712 (13%)
Query: 1433 APAFARDPLALALPENPEPGAALYTFRA----------SDADGPGPNSDVRYRLLRQEPP 1482
APA L ++PE G + ++ G G + YR+L P
Sbjct: 13 APALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAP 72
Query: 1483 VPALRLDARTGALSAPRGLDRETTPA------LLLLVEATDRPANASRRRAARVSARVFV 1536
L +DA +G L + +DRE+ L L V A D+ +V +
Sbjct: 73 -HLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEI---------CMIKVEI 122
Query: 1537 TDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH 1595
D NDNAP F+S + + E+ PG A DPD GE +Y L G F L
Sbjct: 123 QDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLD 182
Query: 1596 SSTGA-------LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
+ L + + LDREQ+ H L + A D G PPRSAT + V V D ND +P
Sbjct: 183 VKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPV 242
Query: 1649 FQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS------SESFSLDPDTGV 1702
F+ Y V L EN P GT ++ L ATD D G NG+V Y S E FS+DP TG+
Sbjct: 243 FEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGL 302
Query: 1703 LTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFG-----SAHLS 1757
+ LD EE + + V A+D G P H V V + D ND+AP+ G LS
Sbjct: 303 IRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALS 362
Query: 1758 LEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGA------------FVLDLASG 1805
P G + ++R +D D G NGQLQ R+L G +G F L+
Sbjct: 363 EAAPPG---TVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYD 419
Query: 1806 EFGTM---RPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV 1862
F T+ RPLDRE + + + I ARDGG P L++T + +LD ND+ P F Y +
Sbjct: 420 NFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVL 479
Query: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTY-----YLGAGTAGAFL-LEPSSGELRTAAA 1916
+V E+ G L + A DPD G NG V+Y ++G + ++ + P++G + +
Sbjct: 480 QVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRS 539
Query: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHA-----PTFPTSPLRLRLPR 1971
+ EQ ++ F V A D A L + +V +TV DVND+A PT L++PR
Sbjct: 540 FNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPR 599
Query: 1972 -PGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVAR----- 2024
G + ++T+RA D D G + + Y + G +D +GEIR
Sbjct: 600 NAGLGY-----LVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWED 654
Query: 2025 -SPVALGPRDRVLFIVATDLGRPARSATGVIIV-GLQGEAERGPRFPRASSE 2074
+PV L + TD G+P SA +I+ + G G PR + E
Sbjct: 655 VTPVV------ELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEG--VPRVNGE 698
Score = 220 bits (561), Expect = 2e-56
Identities = 200/694 (28%), Positives = 296/694 (42%), Gaps = 68/694 (9%)
Query: 140 APAFPQARAALQVPEHTAFGT-----------RYPLEPARDADAGRLGTQGYALSGDGAG 188
APA VPE GT + L PA GR + Y + + A
Sbjct: 13 APALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAP 72
Query: 189 ETFRLETRPGPDGTPVPELVVTGELDRENRSHY----MLQLEAYDGGSPPRRAQALLDVT 244
++ G L +DRE+ + L LE + + ++ V
Sbjct: 73 HLLDVDADSGL-------LYTKQRIDRESLCRHNAKCQLSLEVFAND----KEICMIKVE 121
Query: 245 LLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP 304
+ DIND+AP+F+ + +SE+ APG+ A D DAG NG TY + R + G
Sbjct: 122 IQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTR---DDHGL 178
Query: 305 FSIDAHTG-------LLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 357
F +D + L +++ LD EQ+ H LV+ A DGG P + + V V D+ND
Sbjct: 179 FGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSND 238
Query: 358 NQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEG--GEGHFALS 415
N P +F + ++ E AP G +V ++ +D D+G V S + L
Sbjct: 239 NSP----VFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELF 294
Query: 416 TQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQ 475
+ D L+ V LD EE + V A D G P+ A + + D NDNAP+
Sbjct: 295 SIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFV 354
Query: 476 LYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHW------------FSI 523
R L E A PG+ + V D D G NGQ+ + G T F +
Sbjct: 355 SVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL 414
Query: 524 DPTSG---IITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQR 580
+ + T LD E + + + +VA DGG PPL S+ + ++ + D NDN P+F +
Sbjct: 415 EENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTK 474
Query: 581 TFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYS-LGAGLGSSGSPPF-RIDAHSGDV 638
Y + E PG V A D D G G +SYS L + +G + ++ +G +
Sbjct: 475 GLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAI 534
Query: 639 CTTRTLDRDQGPSSFDFTVTAVDGGG---LKSMVYVKVFLSDENDNPPQFY-PREYAASI 694
R+ + +Q +F+F V A D G L+S V+V + D NDN P P +
Sbjct: 535 YALRSFNFEQ-TKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTA 593
Query: 695 SAQSPP----GTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLAR 750
Q P G V +RA D D G GRL+Y I+ GN LF +D SG + P
Sbjct: 594 ELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWE 653
Query: 751 RANSVVQLEIGAEDGGGLQAEPSARVDISIVPGT 784
VV+L + D G A++ I V G+
Sbjct: 654 DVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGS 687
Score = 215 bits (548), Expect = 5e-55
Identities = 190/655 (29%), Positives = 280/655 (42%), Gaps = 58/655 (8%)
Query: 713 DQGSHGRL---SYHILAGNSPPLFTLDEQSGLLTVAWPLARR------ANSVVQLEIGAE 763
++G GR SY +L ++P L +D SGLL + R A + LE+ A
Sbjct: 52 ERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFAN 111
Query: 764 DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAP 823
D + + + I P F Q + E+ APGT + AH+P
Sbjct: 112 D------KEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENG 165
Query: 824 VTLSLSGGDPRGLFSLDAVSGLLQTLRP-------LDRELLGPVLELEVRAGSGVPPAFA 876
+ L D GLF LD S T P LDRE + G PP A
Sbjct: 166 LRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSA 225
Query: 877 VARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA- 935
++ V + D NDNSP F AP V LP N GT + L A D D G N V ++ +
Sbjct: 226 TVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSY 285
Query: 936 ---GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVG 992
F++DP TG +R+ L E++++ARD G P +H +V V+ +
Sbjct: 286 VPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAH--CKVTVKLID 343
Query: 993 TRGLAPRFNSPTYRVD-LPSGTTAGTQVLQVQAQAPDGGPITY---------------HL 1036
AP + R L GT + V+ D G L
Sbjct: 344 RNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGL 403
Query: 1037 AAEGASSPFGLEPQSGWLWVRAA---LDREAQELYILKVMAVSGSKAELGQQTGTATVRV 1093
G S PF LE + LDRE Q+ Y + ++A G L T + +
Sbjct: 404 GGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPL---NSTKSFAI 460
Query: 1094 SILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL--QQLSEDS 1151
IL++N++ PR ++ L V EN PG +G V A D D G NG ++YS+ + + S
Sbjct: 461 KILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVS 520
Query: 1152 --KAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPR-STTGTVHVAVLDLNDNS 1208
++P G + L++ + EQ +++ V +D G+P + TV V VLD+NDN+
Sbjct: 521 IYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNA 580
Query: 1209 PTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLH 1267
P + + +QVP G LV+T++A D D GE+G + Y + G LF +
Sbjct: 581 PVIVLPT-LQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEID 639
Query: 1268 PHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPP 1322
P SGE+ T P P L + D G P SA +L+++ + S L E P
Sbjct: 640 PSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSV-SGSLPEGVP 693
Score = 211 bits (538), Expect = 7e-54
Identities = 195/668 (29%), Positives = 296/668 (44%), Gaps = 85/668 (12%)
Query: 2191 LQVEADDLDQGSGGQI---SYSLAASQPARGLFHVDPTTGTITTTAILDREIWA------ 2241
LQ ++G GG+ SY + + A L VD +G + T +DRE
Sbjct: 44 LQPGLPPAERGGGGRSKSGSYRVLENS-APHLLDVDADSGLLYTKQRIDRESLCRHNAKC 102
Query: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTG 2300
+ L + A D+ + V + D NDN P+ E+ +SE+A G+ +
Sbjct: 103 QLSLEVFANDKEI------CMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSA 156
Query: 2301 NDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGP------------LDFEQCDRYQ 2346
+D D+G + Y+L+ G +G V G LD EQ + +
Sbjct: 157 HDPDAGENGLRTYLLTRDDH------GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHT 210
Query: 2347 LQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDR 2403
L L A DG P + V V D NDN+P F Y V L E+ P G+ ++ ++ATD
Sbjct: 211 LVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDA 270
Query: 2404 DSGANGHISYHLAS-----PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHG 2458
D G NG + Y +S + FS+DP G L + G L ++ +G +++ ++ARD G
Sbjct: 271 DEGPNGEVLYSFSSYVPDRVRELFSIDPKTG-LIRVKGN--LDYEENGMLEIDVQARDLG 327
Query: 2459 APGRAARATVHVQLQDQNDHAPSFTLSHYRV-AVTEDLPPGSTLLTLEATDADGSRSHAA 2517
A V V+L D+ND+APS R A++E PPG+ + + TD D ++
Sbjct: 328 PNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQL 387
Query: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA----------LGCLVLLEPLDFESLTQ 2567
+ G G G GPG +V PLD E+ +
Sbjct: 388 QCRVLGGGGTG----------GGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDE 437
Query: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
YN+T+ A D G PP +S + +LD NDNPP FT+ Y + V E+ G L V A
Sbjct: 438 YNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQ 497
Query: 2628 DADPGPHGLVRFTV---SSGDPS--GLFELDESSGTLRLAHALDCETQARHQLVVQAADP 2682
D D G +G V +++ GD S ++ ++G + + + E + V A D
Sbjct: 498 DPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDS 557
Query: 2683 -AGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP-----GTLVTTLHAIDGDA 2735
A AH + A V + V DVND+ P L L AE Q P G LV+T+ A+D D
Sbjct: 558 GAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDF 617
Query: 2736 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSA 2795
G GRL Y +++ F ++ S+GE+R PF + T L+V D G +
Sbjct: 618 GESGRLTYEIVDGNDD----HLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTL 673
Query: 2796 SVTVSVLV 2803
S +++
Sbjct: 674 SAVAKLII 681
Score = 204 bits (520), Expect = 9e-52
Identities = 182/635 (28%), Positives = 270/635 (42%), Gaps = 46/635 (7%)
Query: 1033 TYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092
+Y + A ++ SG L+ + +DRE+ + K S ++
Sbjct: 63 SYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQL---SLEVFANDKEICMIK 119
Query: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQ-----L 1147
V I + N+++P S D + ++EN PGT A D D+G NG TY L +
Sbjct: 120 VEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLF 179
Query: 1148 SEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDN 1207
D K+ + E+ + LDREQQ+ + L++ DGG PPRS T ++V V+D NDN
Sbjct: 180 GLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDN 239
Query: 1208 SPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTG----PGSEL 1263
SP F S +++P+ P GT+V L A D DEG NG +LY+ + EL
Sbjct: 240 SPVFEAPS------YLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVREL 293
Query: 1264 FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL------PSARL 1317
FS+ P +G + L E + + A D G P A ++ V+++ PS
Sbjct: 294 FSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGF 353
Query: 1318 AEPPPD-LAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPE 1376
L+E P V ++ VT + + G L V G G +GG
Sbjct: 354 VSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGG----GLGGPGGS 409
Query: 1377 GTFALDAASGRLYLA---RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHA 1433
F L+ Y RPLD E + V +G +++ DEN++
Sbjct: 410 VPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNP 469
Query: 1434 PAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE----PPVPALRLD 1489
P F + L + EN PG L + A D D G N V Y +L + ++
Sbjct: 470 PRFTKGLYVLQVHENNIPGEYLGSVLAQDPD-LGQNGTVSYSILPSHIGDVSIYTYVSVN 528
Query: 1490 ARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASP 1549
GA+ A R + E T A V A D A A A V RV V D NDNAPV P
Sbjct: 529 PTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATV--RVTVLDVNDNAPVIVLP 586
Query: 1550 ------SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSSTGALS 1602
+ +++P + G V A D D GE+ R++Y + G D H F + S+G +
Sbjct: 587 TLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIR 646
Query: 1603 VVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTV 1637
+ P + L V +DHG P SA L +
Sbjct: 647 TLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLII 681
Score = 187 bits (476), Expect = 1e-46
Identities = 174/585 (29%), Positives = 255/585 (43%), Gaps = 67/585 (11%)
Query: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGT--PIVSPRAVHAGGTNGPITYSILSGN 2110
+I V +Q + P F E I ENA PGT P+ S AG NG TY +L+ +
Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAG-ENGLRTY-LLTRD 174
Query: 2111 EKGTFSIQPSTGAITVRSAE-----GLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQ 2162
+ G F + + + E LD E LVL A GG A + + +
Sbjct: 175 DHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVI 234
Query: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQP--ARGLF 2220
D+NDN+P F P Y+ LPE+ PL ++ + A D D+G G++ YS ++ P R LF
Sbjct: 235 DSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELF 294
Query: 2221 HVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI--P 2278
+DP TG I LD E + + A D G + +TV +ID NDN P+I
Sbjct: 295 SIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFV 354
Query: 2279 QPWELRVSEDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSL-- 2333
+ +SE A G+ IA V D DS G + VL G +G GG V
Sbjct: 355 SVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL 414
Query: 2334 ------------TGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQ 2378
PLD E D Y + ++A DG P + + + D NDN P F++
Sbjct: 415 EENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTK 474
Query: 2379 SLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-------FSVDPNNGTL 2431
LY + + E+ PG + SV A D D G NG +SY + G SV+P NG +
Sbjct: 475 GLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAI 534
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGR-AARATVHVQLQDQNDHAPSFTLSHYRVA 2490
+ + + + + A + + A+D GAP + ATV V + D ND+AP L +
Sbjct: 535 YAL---RSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQND 591
Query: 2491 VTEDLPP-----GSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAG 2545
E P G + T+ A D+D S + Y I+ GN +F+++P E
Sbjct: 592 TAELQVPRNAGLGYLVSTVRALDSDFGES-GRLTYEIVDGNDDHLFEIDPSSGE------ 644
Query: 2546 PGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTV 2590
+ L P + L V D G+P S+V + +
Sbjct: 645 --------IRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLII 681
Score = 181 bits (459), Expect = 1e-44
Identities = 133/430 (30%), Positives = 213/430 (49%), Gaps = 40/430 (9%)
Query: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNW 2527
+ V++QD ND+APSF+ + ++E+ PG+ A D D + Y + +
Sbjct: 118 IKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRT-YLLTRDDH 176
Query: 2528 GRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVP 2587
G +F L+ + S G G + LV+ + LD E + L + A D G+PP+S+ V
Sbjct: 177 G-LFGLDVK------SRGDGTK-FPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQ 228
Query: 2588 VTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS 2647
+ V V+D NDN PVF SY V +PE+ P+G ++ + A+DAD GP+G V ++ SS P
Sbjct: 229 INVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPD 288
Query: 2648 ---GLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQDVN 2700
LF +D +G +R+ LD E ++ VQA D P AH VT+++ D N
Sbjct: 289 RVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAH---CKVTVKLIDRN 345
Query: 2701 DHGPAFP-LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAG--------PG 2751
D+ P+ +++ +++E PPGT++ + D D+G G+L+ +L G G
Sbjct: 346 DNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGG 405
Query: 2752 PEGREAFALNSSTGELRARV---PFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGE 2806
P G F L + V P D E + + + + A D G+ L+++ + ++ + E
Sbjct: 406 PGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDE 465
Query: 2807 DEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-------PYF 2859
++ P F + QV E G LG V A D D G +G V YS+ S Y
Sbjct: 466 NDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYV 525
Query: 2860 GINQTTGALY 2869
+N T GA+Y
Sbjct: 526 SVNPTNGAIY 535
Score = 181 bits (458), Expect = 1e-44
Identities = 159/543 (29%), Positives = 249/543 (45%), Gaps = 51/543 (9%)
Query: 2362 LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG 2421
+ V ++D+NDNAP+FS ++ + E+ PG+ SA D D+G NG +Y L G
Sbjct: 118 IKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHG 177
Query: 2422 -FSVDPNN---GTLFT-IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476
F +D + GT F +V AL + +VL A D G P R+A ++V++ D N
Sbjct: 178 LFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSN 237
Query: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV---FQL 2533
D++P F Y V + E+ P G+ ++ L ATDAD + V YS S RV F +
Sbjct: 238 DNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEG-PNGEVLYSFSSYVPDRVRELFSI 296
Query: 2534 EPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVL 2593
+P+ G + + LD+E + V A D G P + VTV ++
Sbjct: 297 DPKT--------------GLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLI 342
Query: 2594 DVNDNPPVFTRASYRV-TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSG---- 2648
D NDN P S R + E P G + V +D D G +G ++ V G +G
Sbjct: 343 DRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGG 402
Query: 2649 --------LFELDESSG---TLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTIEV 2696
F+L+E+ T+ LD ETQ + + + A D + I++
Sbjct: 403 LGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKI 462
Query: 2697 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2756
D ND+ P F L V EN PG + ++ A D D G G + YS+L + G
Sbjct: 463 LDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIY 522
Query: 2757 AF-ALNSSTGELRARVPFDYEHTESFRLLVGAADAG---NLSASVTVSVLVTGEDEYDPV 2812
+ ++N + G + A F++E T++F V A D+G +L ++ TV V V ++ PV
Sbjct: 523 TYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPV 582
Query: 2813 FLAPAFH-----FQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSP--YFGINQTT 2865
+ P QVP A G+ + V+A D D G G + Y + + F I+ ++
Sbjct: 583 IVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSS 642
Query: 2866 GAL 2868
G +
Sbjct: 643 GEI 645
Score = 165 bits (417), Expect = 8e-40
Identities = 183/681 (26%), Positives = 280/681 (41%), Gaps = 72/681 (10%)
Query: 1852 APAFPVPAYSVEVPEDVPAGTLL------LQLQAHDPDA-----GANGHVTYYLGAGTAG 1900
APA + + VPE+ AGT++ +LQ P A G + +Y + +A
Sbjct: 13 APALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAP 72
Query: 1901 AFL-LEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959
L ++ SG L T +DRE + A + + + ++D+ND+AP+
Sbjct: 73 HLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICM-IKVEIQDINDNAPS 131
Query: 1960 FPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLA-------GTPPPGTT 2012
F + + + + + P A D DAG N Y L G
Sbjct: 132 FSSDQIEMDISEN----AAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRG 187
Query: 2013 VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRAS 2072
+ E+ + ++ L + A D G P RSAT I V + + P F S
Sbjct: 188 DGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPS 247
Query: 2073 SEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILS---GNEKGTFSIQPSTGAITVRS 2128
+ ENAP GT ++ A A G NG + YS S + FSI P TG I V+
Sbjct: 248 YLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKG 307
Query: 2129 AEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDANDNAPR--FLRPHYVAFLPES 2183
LD+E + L + +QA G A +T+ L D NDNAP F+ A L E+
Sbjct: 308 --NLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA-LSEA 364
Query: 2184 RPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTG--------------TI 2229
P + V D D G GQ+ + G + G T+
Sbjct: 365 APPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTV 424
Query: 2230 TTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSED 2288
T LDRE E + ++A D GSP L + + + ++D NDN P + + L+V E+
Sbjct: 425 VTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHEN 484
Query: 2289 ALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDP-----FSVGRYGGRVSLTGPLDFEQ 2341
+ G + V D D G + Y + PS D SV G + +FEQ
Sbjct: 485 NIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQ 544
Query: 2342 CDRYQLQLLAHDGPH----EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP-----G 2392
++ ++LA D E A + V V DVNDNAP Q E P G
Sbjct: 545 TKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLG 604
Query: 2393 SAILSVSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTIVGTVALGHDGSGAVDV 2450
+ +V A D D G +G ++Y + D F +DP++G + T+ D + V++
Sbjct: 605 YLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTL---HPFWEDVTPVVEL 661
Query: 2451 VLEARDHGAPGRAARATVHVQ 2471
V++ DHG P +A A + ++
Sbjct: 662 VVKVTDHGKPTLSAVAKLIIR 682
>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
[Homo sapiens]
Length = 837
Score = 317 bits (811), Expect = 2e-85
Identities = 235/679 (34%), Positives = 332/679 (48%), Gaps = 50/679 (7%)
Query: 25 LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGL---PAGTAAPLMYFIS 81
LLLLL + LG + G +A + + EE G+ +G+IS L P A + +S
Sbjct: 13 LLLLLCIFLGT-LRGF--RARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVS 69
Query: 82 AQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVE-------VTVRVA 134
G A++ SG + TA +DRE+ + VE V V +
Sbjct: 70 R----GKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII 125
Query: 135 DINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
DIND+AP+F + ++V EH G R+ L ARD D G Q Y LS + F L+
Sbjct: 126 DINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNY---FSLQ 182
Query: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
R DG PELV+ G LDRE + ++L L A DGG P R+ + V +LD+NDH P
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
Query: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
F QS Y V E+++ G+ VL V A+D D G+NG V Y +S+ F +D+ TG +
Sbjct: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
Query: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQ 374
Q+ LDFE+ R +E+ +Q +DGG + +T V D NDN P +T+
Sbjct: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLIT--VVDVNDNAPEITI----TSSINS 356
Query: 375 VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREE 434
+ E +PPG ++A ++V D D G+ V+ + F L Y + +R LDRE
Sbjct: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFIP-NHLPFKLEKTYGNYYKLITSRVLDREL 415
Query: 435 RDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVR 494
+YN+ +TATD GSPPL AE L+V D NDN P F Y +PE G+ +
Sbjct: 416 VQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAY-IPENNPRGASIFS 474
Query: 495 VTARDPDQGTNGQVTYSLAPGA-----HTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
VTA DPD N VTYSL + + SI+ +G++ S DYE +L V+
Sbjct: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVI 534
Query: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNA----------SLPEGTQPGTCFLQ 599
A D G PPL+S+ ++S+ + D NDN P+ Y A P +PG +
Sbjct: 535 ARDSGDPPLSSNVSLSLFVLDQNDNAPEI---LYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 600 VTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT-LDRDQGPSSFDFTVT 658
V A D DSG LSY L L +S F + H+G+V T R LDRD S V
Sbjct: 592 VVAVDKDSGQNAWLSYRL---LKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQ 648
Query: 659 AVDGGGLKSMVYVKVFLSD 677
L + V + V ++D
Sbjct: 649 DHGQPPLSATVTLTVAVAD 667
Score = 238 bits (607), Expect = 7e-62
Identities = 184/554 (33%), Positives = 258/554 (46%), Gaps = 39/554 (7%)
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHF 1592
V + D NDNAP F +++ E PG ARDPD+G + SY+L+
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSL 181
Query: 1593 RLHSSTGA-----LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAP 1647
+L T L + LDRE+ A H+L + A D G P R + V V DVND P
Sbjct: 182 QLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIP 241
Query: 1648 TFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG-----GVSSESFSLDPDTGV 1702
F Q Y V + EN GT +L + ATDPD G NG+V Y +SE F LD TG
Sbjct: 242 MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGE 301
Query: 1703 LTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE 1762
+ +LD E+ + + QD G T T+ + V D ND+AP + E
Sbjct: 302 VQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILE 359
Query: 1763 GQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFG---TMRPLDREVE 1818
P T + +L D D G NGQ+ I + P F L+ G + T R LDRE+
Sbjct: 360 NSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITSRVLDRELV 416
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
++ + + A D G P LSA + + V D ND+ P FP +YS +PE+ P G + +
Sbjct: 417 QSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVT 476
Query: 1879 AHDPDAGANGHVTYYL------GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAV 1932
A DPD+ N VTY L G + + ++G L + D EQ V A
Sbjct: 477 ALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIAR 536
Query: 1933 DGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG-------PSFSTPTLALAT 1985
D + PLS+ VS+++ V D ND+AP L LP G P + P +
Sbjct: 537 D-SGDPPLSSNVSLSLFVLDQNDNAPEI----LYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 1986 LRAEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLG 2044
+ A D+D+G NA + YRL PG V +TGE+R AR+ + + L + D G
Sbjct: 592 VVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHG 651
Query: 2045 RPARSATGVIIVGL 2058
+P SAT + V +
Sbjct: 652 QPPLSATVTLTVAV 665
Score = 221 bits (563), Expect = 9e-57
Identities = 199/620 (32%), Positives = 284/620 (45%), Gaps = 64/620 (10%)
Query: 1691 SESFSLDPDTGVLTTLRALDREEQEE------INLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
++ F+++P +G L T +DREE E +N+ + +D L V V + D
Sbjct: 73 TQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDT-----LKIYGVEVEIIDI 127
Query: 1745 NDHAPTFGSAHLSLEVPEGQDPQTLTML-RASDPDVGANGQLQYRILDGDPSGAFVLDLA 1803
ND+AP+F + ++V E P L A DPDVG N Y++ P+ F L L
Sbjct: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL---SPNNYFSLQLR 184
Query: 1804 SGEFGTMRP-------LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
G P LDRE E A L + A DGG P + + V VLD NDH P F
Sbjct: 185 GRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFT 244
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY---YLGAGTAGAFLLEPSSGELRT 1913
Y V VPE++ +GT +L + A DPD G NG V Y + + + F L+ +GE++
Sbjct: 245 QSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
Query: 1914 AAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFP-TSPLRLRLPRP 1972
+LD E+ Y + DG G L TT ++ ITV DVND+AP TS + L
Sbjct: 305 RGSLDFEKYRFYEMEIQGQDG---GGLFTTTTMLITVVDVNDNAPEITITSSINSILEN- 360
Query: 1973 GPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPR 2032
S P +A L +D+D+G N + + P +Y ++ S V R
Sbjct: 361 ----SPPGTVIALLNVQDQDSGENGQVSCFIP-NHLPFKLEKTYGNYYKLITSRVL--DR 413
Query: 2033 DRV----LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
+ V + + ATD G P SA + + + + + P FP +S A I EN P G I
Sbjct: 414 ELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIF 473
Query: 2089 SPRAVHAGG-TNGPITYSILSGNEKGT-----FSIQPSTGAITVRSAEGLDFEVSPRLRL 2142
S A+ N +TYS+ +G SI +TG + + + D+E L L
Sbjct: 474 SVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVL--YALQSFDYEQFRDLEL 531
Query: 2143 VLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY-------VAFLPESRPLEGPLLQ 2192
+ A G + L+L + D NDNAP L P V P S + +
Sbjct: 532 RVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 2193 VEADDLDQGSGGQISYS-LAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMAT 2250
V A D D G +SY L AS+P GLF V TG + T A+LDR+ ++ LV+
Sbjct: 592 VVAVDKDSGQNAWLSYRLLKASEP--GLFAVGEHTGEVRTARALLDRDALKQS-LVVAVQ 648
Query: 2251 DRGSPALVGSATLTVMVIDT 2270
D G P L + TLTV V D+
Sbjct: 649 DHGQPPLSATVTLTVAVADS 668
Score = 204 bits (518), Expect = 2e-51
Identities = 183/630 (29%), Positives = 284/630 (45%), Gaps = 48/630 (7%)
Query: 790 FEQLQYVFSVPEDVAPGTSVGIVQAH--NPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQ 847
F Q +SVPE+ G+ VG + P LA + + LF+++ SG L
Sbjct: 27 FRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLI 86
Query: 848 TLRPLDR-ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPN 906
T +DR EL V + V + V V + D+NDN+P+F E + + +
Sbjct: 87 TAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEH 146
Query: 907 TAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVR-----LMRPLGPSGG 961
PG A DPD GVNS ++ L + + T + L L
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
Query: 962 PAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQ 1021
AH L L A DGG P R +RVVV DV P F YRV +P ++GT+VL
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH--IPMFTQSVYRVSVPENISSGTRVLM 264
Query: 1022 VQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVS 1076
V A PD G ++ AS F L+ Q+G + VR +LD E Y +++
Sbjct: 265 VNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQD 324
Query: 1077 GSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGP 1136
G G T T+ +++++ N+++P ++ + ++ EN PPGT + + D+DSG
Sbjct: 325 G-----GGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGE 379
Query: 1137 NGRLTYSLQQLSEDSKAFRIHPQTG---EVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
NG+++ + + F++ G ++ T + LDRE SY + + D GSPP S
Sbjct: 380 NGQVSCFI----PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSA 435
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
V + V D NDN P F +S +A +P+ P G + ++ A DPD +N +
Sbjct: 436 ETHVWLNVADDNDNPPVFPHSSYSA------YIPENNPRGASIFSVTALDPDSKQNALVT 489
Query: 1254 YTLTG------PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQL 1307
Y+LT P S S++ ++G L + L + A D G PP S+++ L
Sbjct: 490 YSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSL 549
Query: 1308 LVQVLPSARLAEPPPDLAERDPAAPVPVVLTV-TAAEGLRPGSLLGS-VAAPEPAGVGA- 1364
+ VL + P++ PA P V A PG L+ VA + +G A
Sbjct: 550 SLFVLDQ---NDNAPEILY--PALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAW 604
Query: 1365 LTYTLVGGADPEGTFALDAASGRLYLARPL 1394
L+Y L+ ++P G FA+ +G + AR L
Sbjct: 605 LSYRLLKASEP-GLFAVGEHTGEVRTARAL 633
Score = 201 bits (512), Expect = 8e-51
Identities = 192/634 (30%), Positives = 296/634 (46%), Gaps = 92/634 (14%)
Query: 2219 LFHVDPTTGTITTTAILDREIWAET------RLVLMATDRGSPALVGSATLTVMVIDTND 2272
LF V+P +G++ T +DRE ET + L+ D + + G + V +ID ND
Sbjct: 75 LFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVED--TLKIYG---VEVEIIDIND 129
Query: 2273 NRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFSVGRYGG 2329
N P+ + E++VSE A+ G+ A D D G + Y LSP+ GR G
Sbjct: 130 NAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDG 189
Query: 2330 ----RVSLTGPLDFEQCDRYQLQLLAHDGP---HEGRANLTVLVEDVNDNAPAFSQSLYQ 2382
+ L G LD E+ + L L A DG +G + V+V DVND+ P F+QS+Y+
Sbjct: 190 AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYR 249
Query: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHL----ASPADGFSVDPNNGTLFTIVGTV 2438
V + E+ G+ +L V+ATD D G NG + Y + ++ F +D G + + G+
Sbjct: 250 VSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV-QVRGS- 307
Query: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
L + ++ ++ +D G G T+ + + D ND+AP T++ ++ E+ PPG
Sbjct: 308 -LDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
Query: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRV---------FQLEPRLAEAGESAGPGPR 2549
+ + L D D SG G+V F+LE +
Sbjct: 365 TVIALLNVQDQD-------------SGENGQVSCFIPNHLPFKLEKTYGNYYK------- 404
Query: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRV 2609
L+ LD E + YN+T+ A D+G PP S+ V + V D NDNPPVF +SY
Sbjct: 405 ----LITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
Query: 2610 TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGL-----FELDESSGTLRLAHA 2664
+PE+ P GA + V A D D + LV ++++ G+ ++ ++G L +
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520
Query: 2665 LDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTS------ 2714
D E +L V A D P ++ +L ++ V D ND+ P L T
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSL---SLFVLDQNDNAPEILYPALPTDGSTGVE 577
Query: 2715 -VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAG-PGPEGREAFALNSSTGELR-ARV 2771
+ PG LVT + A+D D+G L Y LL+A PG FA+ TGE+R AR
Sbjct: 578 LAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPG-----LFAVGEHTGEVRTARA 632
Query: 2772 PFDYEHTESFRLLVGAADAGN--LSASVTVSVLV 2803
D + + L+V D G LSA+VT++V V
Sbjct: 633 LLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAV 665
Score = 193 bits (490), Expect = 3e-48
Identities = 190/670 (28%), Positives = 288/670 (42%), Gaps = 62/670 (9%)
Query: 175 LGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR----SHYMLQLEAYDG 230
L +G + G + F + R G L+ G +DRE S L +E
Sbjct: 60 LAKRGVRIVSRGKTQLFAVNPRSG-------SLITAGRIDREELCETVSSCFLNMELLVE 112
Query: 231 GSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAV 290
+ ++V ++DIND+AP+F + VSE PG+ A D D GVN
Sbjct: 113 DTLKIYG---VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQ 169
Query: 291 TYEIN-------RRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPEL 343
+Y+++ + + DG A L LE LD E+ H L++ A DGG
Sbjct: 170 SYQLSPNNYFSLQLRGRTDG-----AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRK 224
Query: 344 GSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNV 403
G+ + V V D ND+ P +F + V E G V ++ +DPD+G V
Sbjct: 225 GAVPIRVVVLDVNDHIP----MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY 280
Query: 404 SLEGGEGHFALSTQ-DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHV 462
S E + Q DS V V LD E+ Y + + D G L ++ V
Sbjct: 281 SFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITV 338
Query: 463 TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFS 522
DVNDNAP L E + PG+ + + +D D G NGQV+ + F
Sbjct: 339 VDVNDNAPEITITSSINSIL-ENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FK 394
Query: 523 IDPTSGI---ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
++ T G + T+ LD EL + + ATD G PPL++ V + + D NDN P F
Sbjct: 395 LEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFP 454
Query: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSL------GAGLGSSGSPPFRIDA 633
+ Y+A +PE G VTA D DS L++YSL G L S S I++
Sbjct: 455 HSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS----INS 510
Query: 634 HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFY----P 687
++G + ++ D +Q + V A D G L S V + +F+ D+NDN P+ P
Sbjct: 511 NTGVLYALQSFDYEQF-RDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALP 569
Query: 688 REYAASISA---QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV 744
+ + + + PG V ++ A D D G + LSY +L + P LF + E +G +
Sbjct: 570 TDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRT 629
Query: 745 AWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVA 804
A L R L + +D G Q SA V +++ P + L + S+
Sbjct: 630 ARALLDRDALKQSLVVAVQDHG--QPPLSATVTLTVAVADSIPEVLADLGSLESLANSET 687
Query: 805 PGTSVGIVQA 814
S+ +V A
Sbjct: 688 SDLSLYLVVA 697
Score = 192 bits (487), Expect = 6e-48
Identities = 193/700 (27%), Positives = 303/700 (43%), Gaps = 76/700 (10%)
Query: 2317 GPQDPFSVGRYGGRVSLTGPLDFEQ-CDRYQ-----LQLLAHDGPHEGRANLTVLVEDVN 2370
G F+V G + G +D E+ C+ ++LL D + ++ D+N
Sbjct: 71 GKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII--DIN 128
Query: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGT 2430
DNAP+F + ++ + EH PG+ +A D D G N SY L SP + FS+ T
Sbjct: 129 DNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQLRGRT 187
Query: 2431 LFT----IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
+V +L + A ++L A D G P R + V + D NDH P FT S
Sbjct: 188 DGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSV 247
Query: 2487 YRVAVTEDLPPGSTLLTLEATDAD-GSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAG 2545
YRV+V E++ G+ +L + ATD D G + + +FQL+ ++ GE
Sbjct: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLD---SQTGEVQV 304
Query: 2546 PGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA 2605
G LDFE Y + + D G + + +TV+DVNDN P T
Sbjct: 305 RGS-----------LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITIT 351
Query: 2606 SYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT---LRLA 2662
S ++ E++P G + + D D G +G V + + P F+L+++ G L +
Sbjct: 352 SSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITS 408
Query: 2663 HALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP 2721
LD E + + + A D A V + V D ND+ P FP + S + EN P
Sbjct: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPR 468
Query: 2722 GTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGREAFALNSSTGELRARVPFDYEHTES 2780
G + ++ A+D D+ + YSL + G ++NS+TG L A FDYE
Sbjct: 469 GASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRD 528
Query: 2781 FRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-------VPEGARRGHS 2831
L V A D+G+ LS++V++S+ V +++ P L PA P A G+
Sbjct: 529 LELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYL 588
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGR 2889
+ V A D+D G + + Y L A+ F + + TG + +
Sbjct: 589 VTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEV--------------RTARALL 634
Query: 2890 TRREAPRELRLEVIARGPLPGSRSATVPVTV------------DITHTALGLAPDLNLLL 2937
R + L + V G P S + T+ V V + A DL+L L
Sbjct: 635 DRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLESLANSETSDLSLYL 694
Query: 2938 VGAVAASLGVVVVLALAALVLGLVR-ARSRKAEAAPGPMS 2976
V AVAA + +V + L L L R +SR +A+ G ++
Sbjct: 695 VVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGLA 734
Score = 186 bits (473), Expect = 3e-46
Identities = 177/644 (27%), Positives = 269/644 (41%), Gaps = 81/644 (12%)
Query: 1036 LAAEGASSPFGLEPQSGWLWVRAALDREA-----------QELYILKVMAVSGSKAELGQ 1084
+ + G + F + P+SG L +DRE EL + + + G
Sbjct: 67 IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG------- 119
Query: 1085 QTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
V V I++ N+++P ED + V+E+ PG A D D G N +Y L
Sbjct: 120 ------VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL 173
Query: 1145 QQLSEDSKAFRIHP---QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201
+ S R + E+ +LDRE+++++ LL+ DGG P R + V V
Sbjct: 174 SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVV 233
Query: 1202 LDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT---LTG 1258
LD+ND+ P F Q+ + VP+ + GT V + A DPDEG NG ++Y+ +
Sbjct: 234 LDVNDHIPMFTQSV------YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMES 287
Query: 1259 PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL----PS 1314
SE+F L +GE+ L + Y + + D G + ++ + V + P
Sbjct: 288 KASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPE 347
Query: 1315 ARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGAD 1374
+ + E P V +L V + G + + P
Sbjct: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP--------------- 392
Query: 1375 PEGTFALDAASGRLY---LARPLDFEAGPPWR-ALTVRAEGPGGAGARLLRVQVQVQDEN 1430
F L+ G Y +R LD E + LT +G A V + V D+N
Sbjct: 393 ----FKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAET-HVWLNVADDN 447
Query: 1431 EHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRL----LRQEPPVPAL 1486
++ P F + +PEN GA++++ A D D N+ V Y L ++ P +
Sbjct: 448 DNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSK-QNALVTYSLTDDTVQGVPLSSYV 506
Query: 1487 RLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF 1546
+++ TG L A + D E L L V A D + ++ VS +FV D+NDNAP
Sbjct: 507 SINSNTGVLYALQSFDYEQFRDLELRVIARD---SGDPPLSSNVSLSLFVLDQNDNAPEI 563
Query: 1547 ASPSR-------VRL-PEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSS 1597
P+ V L P PG VVA D D G+ A +SYRL + G F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEH 623
Query: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVAD 1641
TG + R L + L V DHG PP SAT LTV+VAD
Sbjct: 624 TGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 179 bits (455), Expect = 3e-44
Identities = 170/618 (27%), Positives = 263/618 (42%), Gaps = 43/618 (6%)
Query: 724 ILAGNSPPLFTLDEQSGLLTVAWPLARR------ANSVVQLEIGAEDGGGLQAEPSARVD 777
I++ LF ++ +SG L A + R ++ + +E+ ED + V+
Sbjct: 67 IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG-----VE 121
Query: 778 ISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLF 837
+ I+ P F++ + V E PG + A +P + +L P F
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPD--VGVNSLQSYQLSPNNYF 179
Query: 838 SLD-------AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
SL A + L LDRE L L G P +RV++ DVND+
Sbjct: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFT---LLAGGGGAFTVDPTT 947
P F V +P N + GT + + A DPD G+N V ++ + + F +D T
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQT 299
Query: 948 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
G V++ L +E+E++ +DGG T+ + VV DV AP +
Sbjct: 300 GEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV--DVNDN--APEITITSSIN 355
Query: 1008 DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG---WLWVRAALDREA 1064
+ + GT + + Q D G PF LE G L LDRE
Sbjct: 356 SILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDREL 415
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
+ Y + + A L +T V +++ + N++ P + EN P G S+
Sbjct: 416 VQSYNITLTATDQGSPPLSAETH---VWLNVADDNDNPPVFPHSSYSAYIPENNPRGASI 472
Query: 1125 GRVFATDRDSGPNGRLTYSLQQLSED----SKAFRIHPQTGEVTTLQTLDREQQSSYQLL 1180
V A D DS N +TYSL + S I+ TG + LQ+ D EQ +L
Sbjct: 473 FSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELR 532
Query: 1181 VQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV-PDRVPPGTLVTTL 1239
V +D G PP S+ ++ + VLD NDN+P L + G +++ P PG LVT +
Sbjct: 533 VIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKV 592
Query: 1240 QAKDPDEGENGTILYTL---TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296
A D D G+N + Y L + PG LF++ H+GE+ TA L+ + L ++ D
Sbjct: 593 VAVDKDSGQNAWLSYRLLKASEPG--LFAVGEHTGEVRTARALLDRDALKQSLVVAVQDH 650
Query: 1297 GSPPRSASLQLLVQVLPS 1314
G PP SA++ L V V S
Sbjct: 651 GQPPLSATVTLTVAVADS 668
Score = 164 bits (416), Expect = 1e-39
Identities = 178/651 (27%), Positives = 274/651 (42%), Gaps = 60/651 (9%)
Query: 482 LPEVALPGSFVVRVT---ARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDY 538
+PE GSFV ++ +P + V + T F+++P SG + TA +D
Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVR--IVSRGKTQLFAVNPRSGSLITAGRIDR 93
Query: 539 E-LEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCF 597
E L + + + V V + D+NDN P FQ + E PG F
Sbjct: 94 EELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARF 153
Query: 598 LQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRID-AHSGDVCTTRTLDRDQGPSSFDFT 656
A D D G L SY L S R D A + ++ +LDR++ +
Sbjct: 154 ALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHL-LL 212
Query: 657 VTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQ 714
+TA+DGG K V ++V + D ND+ P F Y S+ GT VL + A DPD+
Sbjct: 213 LTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDE 272
Query: 715 GSHGRLSYHI--LAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEP 772
G +G + Y + + +F LD Q+G + V L ++EI +DGGGL
Sbjct: 273 GINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFT-- 330
Query: 773 SARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGG 831
+ + I++V P + S+ E+ PGT + ++ + G V+ +
Sbjct: 331 TTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNH 390
Query: 832 DPRGLFSLDAVSG---LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVN 888
P F L+ G L T R LDREL+ G PP A V + + D N
Sbjct: 391 LP---FKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDN 447
Query: 889 DNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG------GGAFT 942
DN P FP + +P N G I+++ ALDPDS N+ VT++L +
Sbjct: 448 DNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS 507
Query: 943 VDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDV----------- 991
++ TG + ++ EL + ARD G PP +S+ L + V D
Sbjct: 508 INSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPA 567
Query: 992 ----GTRG--LAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPF 1045
G+ G LAPR P Y V T+V+ V + ++Y L F
Sbjct: 568 LPTDGSTGVELAPRSAEPGYLV---------TKVVAVDKDSGQNAWLSYRLLKASEPGLF 618
Query: 1046 GLEPQSGWL-WVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI 1095
+ +G + RA LDR+A + + V+AV + GQ +ATV +++
Sbjct: 619 AVGEHTGEVRTARALLDRDALKQSL--VVAVQ----DHGQPPLSATVTLTV 663
Score = 149 bits (377), Expect = 3e-35
Identities = 152/560 (27%), Positives = 230/560 (41%), Gaps = 48/560 (8%)
Query: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAF 1902
V ++D ND+AP+F ++V E G A DPD G N +Y L +
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSL 181
Query: 1903 LLE-----PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLST-TVSVTITVRDVNDH 1956
L + EL +LDRE+ ++ ++A+DG P+ V + + V DVNDH
Sbjct: 182 QLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGG--DPIRKGAVPIRVVVLDVNDH 239
Query: 1957 APTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV--- 2013
P F S R+ +P + S+ T L + A D D G N ++Y + +
Sbjct: 240 IPMFTQSVYRVSVPE---NISSGTRVLM-VNATDPDEGINGEVMYSFRNMESKASEIFQL 295
Query: 2014 DSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASS 2073
DS TGE++V S R + I D G T +++ + + P SS
Sbjct: 296 DSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSS 353
Query: 2074 EATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAI-TVRSAEG 2131
+I EN+PPGT I G NG ++ I + F ++ + G + ++
Sbjct: 354 INSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITSRV 410
Query: 2132 LDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEG 2188
LD E+ + L A G+ A T + L + D NDN P F Y A++PE+ P
Sbjct: 411 LDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGA 470
Query: 2189 PLLQVEADDLDQGSGGQISYSLAASQ----PARGLFHVDPTTGTITTTAILDREIWAETR 2244
+ V A D D ++YSL P ++ TG + D E + +
Sbjct: 471 SIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE 530
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIA-------- 2296
L ++A D G P L + +L++ V+D NDN P I P + D G E+A
Sbjct: 531 LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYP---ALPTDGSTGVELAPRSAEPGY 587
Query: 2297 ---QVTGNDVDSGPVLW--YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLA 2351
+V D DSG W Y L + F+VG + G V L + L +
Sbjct: 588 LVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAV 647
Query: 2352 HD---GPHEGRANLTVLVED 2368
D P LTV V D
Sbjct: 648 QDHGQPPLSATVTLTVAVAD 667
Score = 110 bits (276), Expect = 2e-23
Identities = 103/375 (27%), Positives = 156/375 (41%), Gaps = 36/375 (9%)
Query: 2525 GNWGRVFQLEPR-LAEAG---------ESAGPGPRALGCLVLLEPLDFESLTQ------Y 2568
GN + LEPR LA+ G + PR+ G L+ +D E L +
Sbjct: 47 GNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRS-GSLITAGRIDREELCETVSSCFL 105
Query: 2569 NLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASD 2628
N+ + D + V V ++D+NDN P F + V E GA A D
Sbjct: 106 NMELLVEDT-----LKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARD 160
Query: 2629 ADPGPHGLVRFTVSSGDPSGLFELDESSGT-------LRLAHALDCETQARHQLVVQAAD 2681
D G + L + +S P+ F L T L L +LD E +A H L++ A D
Sbjct: 161 PDVGVNSLQSYQLS---PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALD 217
Query: 2682 PAGA-HFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGR 2740
P+ + V DVNDH P F ++ SV EN GT V ++A D D G G
Sbjct: 218 GGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGE 277
Query: 2741 LRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVS 2800
+ YS + E F L+S TGE++ R D+E + + + D G L + T+
Sbjct: 278 VMYSFRNMES--KASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTML 335
Query: 2801 VLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFG 2860
+ V ++ P + + E + G + + D+D G +G V + P F
Sbjct: 336 ITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP-FK 394
Query: 2861 INQTTGALYLRVDSR 2875
+ +T G Y + SR
Sbjct: 395 LEKTYGNYYKLITSR 409
>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
[Homo sapiens]
Length = 935
Score = 317 bits (811), Expect = 2e-85
Identities = 235/679 (34%), Positives = 332/679 (48%), Gaps = 50/679 (7%)
Query: 25 LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGL---PAGTAAPLMYFIS 81
LLLLL + LG + G +A + + EE G+ +G+IS L P A + +S
Sbjct: 13 LLLLLCIFLGT-LRGF--RARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVS 69
Query: 82 AQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVE-------VTVRVA 134
G A++ SG + TA +DRE+ + VE V V +
Sbjct: 70 R----GKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII 125
Query: 135 DINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
DIND+AP+F + ++V EH G R+ L ARD D G Q Y LS + F L+
Sbjct: 126 DINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNY---FSLQ 182
Query: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
R DG PELV+ G LDRE + ++L L A DGG P R+ + V +LD+NDH P
Sbjct: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
Query: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
F QS Y V E+++ G+ VL V A+D D G+NG V Y +S+ F +D+ TG +
Sbjct: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
Query: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQ 374
Q+ LDFE+ R +E+ +Q +DGG + +T V D NDN P +T+
Sbjct: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLIT--VVDVNDNAPEITI----TSSINS 356
Query: 375 VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREE 434
+ E +PPG ++A ++V D D G+ V+ + F L Y + +R LDRE
Sbjct: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFIP-NHLPFKLEKTYGNYYKLITSRVLDREL 415
Query: 435 RDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVR 494
+YN+ +TATD GSPPL AE L+V D NDN P F Y +PE G+ +
Sbjct: 416 VQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAY-IPENNPRGASIFS 474
Query: 495 VTARDPDQGTNGQVTYSLAPGA-----HTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
VTA DPD N VTYSL + + SI+ +G++ S DYE +L V+
Sbjct: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVI 534
Query: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNA----------SLPEGTQPGTCFLQ 599
A D G PPL+S+ ++S+ + D NDN P+ Y A P +PG +
Sbjct: 535 ARDSGDPPLSSNVSLSLFVLDQNDNAPEI---LYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 600 VTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT-LDRDQGPSSFDFTVT 658
V A D DSG LSY L L +S F + H+G+V T R LDRD S V
Sbjct: 592 VVAVDKDSGQNAWLSYRL---LKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQ 648
Query: 659 AVDGGGLKSMVYVKVFLSD 677
L + V + V ++D
Sbjct: 649 DHGQPPLSATVTLTVAVAD 667
Score = 238 bits (607), Expect = 7e-62
Identities = 184/554 (33%), Positives = 258/554 (46%), Gaps = 39/554 (7%)
Query: 1534 VFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHF 1592
V + D NDNAP F +++ E PG ARDPD+G + SY+L+
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSL 181
Query: 1593 RLHSSTGA-----LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAP 1647
+L T L + LDRE+ A H+L + A D G P R + V V DVND P
Sbjct: 182 QLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIP 241
Query: 1648 TFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG-----GVSSESFSLDPDTGV 1702
F Q Y V + EN GT +L + ATDPD G NG+V Y +SE F LD TG
Sbjct: 242 MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGE 301
Query: 1703 LTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE 1762
+ +LD E+ + + QD G T T+ + V D ND+AP + E
Sbjct: 302 VQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILE 359
Query: 1763 GQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFG---TMRPLDREVE 1818
P T + +L D D G NGQ+ I + P F L+ G + T R LDRE+
Sbjct: 360 NSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITSRVLDRELV 416
Query: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
++ + + A D G P LSA + + V D ND+ P FP +YS +PE+ P G + +
Sbjct: 417 QSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVT 476
Query: 1879 AHDPDAGANGHVTYYL------GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAV 1932
A DPD+ N VTY L G + + ++G L + D EQ V A
Sbjct: 477 ALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIAR 536
Query: 1933 DGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG-------PSFSTPTLALAT 1985
D + PLS+ VS+++ V D ND+AP L LP G P + P +
Sbjct: 537 D-SGDPPLSSNVSLSLFVLDQNDNAPEI----LYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 1986 LRAEDRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLG 2044
+ A D+D+G NA + YRL PG V +TGE+R AR+ + + L + D G
Sbjct: 592 VVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHG 651
Query: 2045 RPARSATGVIIVGL 2058
+P SAT + V +
Sbjct: 652 QPPLSATVTLTVAV 665
Score = 221 bits (563), Expect = 9e-57
Identities = 199/620 (32%), Positives = 284/620 (45%), Gaps = 64/620 (10%)
Query: 1691 SESFSLDPDTGVLTTLRALDREEQEE------INLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
++ F+++P +G L T +DREE E +N+ + +D L V V + D
Sbjct: 73 TQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDT-----LKIYGVEVEIIDI 127
Query: 1745 NDHAPTFGSAHLSLEVPEGQDPQTLTML-RASDPDVGANGQLQYRILDGDPSGAFVLDLA 1803
ND+AP+F + ++V E P L A DPDVG N Y++ P+ F L L
Sbjct: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL---SPNNYFSLQLR 184
Query: 1804 SGEFGTMRP-------LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
G P LDRE E A L + A DGG P + + V VLD NDH P F
Sbjct: 185 GRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFT 244
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY---YLGAGTAGAFLLEPSSGELRT 1913
Y V VPE++ +GT +L + A DPD G NG V Y + + + F L+ +GE++
Sbjct: 245 QSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
Query: 1914 AAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFP-TSPLRLRLPRP 1972
+LD E+ Y + DG G L TT ++ ITV DVND+AP TS + L
Sbjct: 305 RGSLDFEKYRFYEMEIQGQDG---GGLFTTTTMLITVVDVNDNAPEITITSSINSILEN- 360
Query: 1973 GPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPR 2032
S P +A L +D+D+G N + + P +Y ++ S V R
Sbjct: 361 ----SPPGTVIALLNVQDQDSGENGQVSCFIP-NHLPFKLEKTYGNYYKLITSRVL--DR 413
Query: 2033 DRV----LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088
+ V + + ATD G P SA + + + + + P FP +S A I EN P G I
Sbjct: 414 ELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIF 473
Query: 2089 SPRAVHAGG-TNGPITYSILSGNEKGT-----FSIQPSTGAITVRSAEGLDFEVSPRLRL 2142
S A+ N +TYS+ +G SI +TG + + + D+E L L
Sbjct: 474 SVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVL--YALQSFDYEQFRDLEL 531
Query: 2143 VLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY-------VAFLPESRPLEGPLLQ 2192
+ A G + L+L + D NDNAP L P V P S + +
Sbjct: 532 RVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTK 591
Query: 2193 VEADDLDQGSGGQISYS-LAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMAT 2250
V A D D G +SY L AS+P GLF V TG + T A+LDR+ ++ LV+
Sbjct: 592 VVAVDKDSGQNAWLSYRLLKASEP--GLFAVGEHTGEVRTARALLDRDALKQS-LVVAVQ 648
Query: 2251 DRGSPALVGSATLTVMVIDT 2270
D G P L + TLTV V D+
Sbjct: 649 DHGQPPLSATVTLTVAVADS 668
Score = 204 bits (518), Expect = 2e-51
Identities = 183/630 (29%), Positives = 284/630 (45%), Gaps = 48/630 (7%)
Query: 790 FEQLQYVFSVPEDVAPGTSVGIVQAH--NPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQ 847
F Q +SVPE+ G+ VG + P LA + + LF+++ SG L
Sbjct: 27 FRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLI 86
Query: 848 TLRPLDR-ELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPN 906
T +DR EL V + V + V V + D+NDN+P+F E + + +
Sbjct: 87 TAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEH 146
Query: 907 TAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVR-----LMRPLGPSGG 961
PG A DPD GVNS ++ L + + T + L L
Sbjct: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
Query: 962 PAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQ 1021
AH L L A DGG P R +RVVV DV P F YRV +P ++GT+VL
Sbjct: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH--IPMFTQSVYRVSVPENISSGTRVLM 264
Query: 1022 VQAQAPDGG-----PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVS 1076
V A PD G ++ AS F L+ Q+G + VR +LD E Y +++
Sbjct: 265 VNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQD 324
Query: 1077 GSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGP 1136
G G T T+ +++++ N+++P ++ + ++ EN PPGT + + D+DSG
Sbjct: 325 G-----GGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGE 379
Query: 1137 NGRLTYSLQQLSEDSKAFRIHPQTG---EVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
NG+++ + + F++ G ++ T + LDRE SY + + D GSPP S
Sbjct: 380 NGQVSCFI----PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSA 435
Query: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
V + V D NDN P F +S +A +P+ P G + ++ A DPD +N +
Sbjct: 436 ETHVWLNVADDNDNPPVFPHSSYSA------YIPENNPRGASIFSVTALDPDSKQNALVT 489
Query: 1254 YTLTG------PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQL 1307
Y+LT P S S++ ++G L + L + A D G PP S+++ L
Sbjct: 490 YSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSL 549
Query: 1308 LVQVLPSARLAEPPPDLAERDPAAPVPVVLTV-TAAEGLRPGSLLGS-VAAPEPAGVGA- 1364
+ VL + P++ PA P V A PG L+ VA + +G A
Sbjct: 550 SLFVLDQ---NDNAPEILY--PALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAW 604
Query: 1365 LTYTLVGGADPEGTFALDAASGRLYLARPL 1394
L+Y L+ ++P G FA+ +G + AR L
Sbjct: 605 LSYRLLKASEP-GLFAVGEHTGEVRTARAL 633
Score = 201 bits (512), Expect = 8e-51
Identities = 192/634 (30%), Positives = 296/634 (46%), Gaps = 92/634 (14%)
Query: 2219 LFHVDPTTGTITTTAILDREIWAET------RLVLMATDRGSPALVGSATLTVMVIDTND 2272
LF V+P +G++ T +DRE ET + L+ D + + G + V +ID ND
Sbjct: 75 LFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVED--TLKIYG---VEVEIIDIND 129
Query: 2273 NRPTIPQPW-ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPSGPQDPFSVGRYGG 2329
N P+ + E++VSE A+ G+ A D D G + Y LSP+ GR G
Sbjct: 130 NAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDG 189
Query: 2330 ----RVSLTGPLDFEQCDRYQLQLLAHDGP---HEGRANLTVLVEDVNDNAPAFSQSLYQ 2382
+ L G LD E+ + L L A DG +G + V+V DVND+ P F+QS+Y+
Sbjct: 190 AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYR 249
Query: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHL----ASPADGFSVDPNNGTLFTIVGTV 2438
V + E+ G+ +L V+ATD D G NG + Y + ++ F +D G + + G+
Sbjct: 250 VSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV-QVRGS- 307
Query: 2439 ALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPG 2498
L + ++ ++ +D G G T+ + + D ND+AP T++ ++ E+ PPG
Sbjct: 308 -LDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
Query: 2499 STLLTLEATDADGSRSHAAVDYSIISGNWGRV---------FQLEPRLAEAGESAGPGPR 2549
+ + L D D SG G+V F+LE +
Sbjct: 365 TVIALLNVQDQD-------------SGENGQVSCFIPNHLPFKLEKTYGNYYK------- 404
Query: 2550 ALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRV 2609
L+ LD E + YN+T+ A D+G PP S+ V + V D NDNPPVF +SY
Sbjct: 405 ----LITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
Query: 2610 TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGL-----FELDESSGTLRLAHA 2664
+PE+ P GA + V A D D + LV ++++ G+ ++ ++G L +
Sbjct: 461 YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS 520
Query: 2665 LDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTS------ 2714
D E +L V A D P ++ +L ++ V D ND+ P L T
Sbjct: 521 FDYEQFRDLELRVIARDSGDPPLSSNVSL---SLFVLDQNDNAPEILYPALPTDGSTGVE 577
Query: 2715 -VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAG-PGPEGREAFALNSSTGELR-ARV 2771
+ PG LVT + A+D D+G L Y LL+A PG FA+ TGE+R AR
Sbjct: 578 LAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPG-----LFAVGEHTGEVRTARA 632
Query: 2772 PFDYEHTESFRLLVGAADAGN--LSASVTVSVLV 2803
D + + L+V D G LSA+VT++V V
Sbjct: 633 LLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAV 665
Score = 193 bits (490), Expect = 3e-48
Identities = 190/670 (28%), Positives = 288/670 (42%), Gaps = 62/670 (9%)
Query: 175 LGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR----SHYMLQLEAYDG 230
L +G + G + F + R G L+ G +DRE S L +E
Sbjct: 60 LAKRGVRIVSRGKTQLFAVNPRSG-------SLITAGRIDREELCETVSSCFLNMELLVE 112
Query: 231 GSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAV 290
+ ++V ++DIND+AP+F + VSE PG+ A D D GVN
Sbjct: 113 DTLKIYG---VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQ 169
Query: 291 TYEIN-------RRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPEL 343
+Y+++ + + DG A L LE LD E+ H L++ A DGG
Sbjct: 170 SYQLSPNNYFSLQLRGRTDG-----AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRK 224
Query: 344 GSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNV 403
G+ + V V D ND+ P +F + V E G V ++ +DPD+G V
Sbjct: 225 GAVPIRVVVLDVNDHIP----MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY 280
Query: 404 SLEGGEGHFALSTQ-DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHV 462
S E + Q DS V V LD E+ Y + + D G L ++ V
Sbjct: 281 SFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITV 338
Query: 463 TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFS 522
DVNDNAP L E + PG+ + + +D D G NGQV+ + F
Sbjct: 339 VDVNDNAPEITITSSINSIL-ENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FK 394
Query: 523 IDPTSGI---ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
++ T G + T+ LD EL + + ATD G PPL++ V + + D NDN P F
Sbjct: 395 LEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFP 454
Query: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSL------GAGLGSSGSPPFRIDA 633
+ Y+A +PE G VTA D DS L++YSL G L S S I++
Sbjct: 455 HSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS----INS 510
Query: 634 HSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFY----P 687
++G + ++ D +Q + V A D G L S V + +F+ D+NDN P+ P
Sbjct: 511 NTGVLYALQSFDYEQF-RDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALP 569
Query: 688 REYAASISA---QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV 744
+ + + + PG V ++ A D D G + LSY +L + P LF + E +G +
Sbjct: 570 TDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRT 629
Query: 745 AWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVA 804
A L R L + +D G Q SA V +++ P + L + S+
Sbjct: 630 ARALLDRDALKQSLVVAVQDHG--QPPLSATVTLTVAVADSIPEVLADLGSLESLANSET 687
Query: 805 PGTSVGIVQA 814
S+ +V A
Sbjct: 688 SDLSLYLVVA 697
Score = 192 bits (487), Expect = 6e-48
Identities = 193/700 (27%), Positives = 303/700 (43%), Gaps = 76/700 (10%)
Query: 2317 GPQDPFSVGRYGGRVSLTGPLDFEQ-CDRYQ-----LQLLAHDGPHEGRANLTVLVEDVN 2370
G F+V G + G +D E+ C+ ++LL D + ++ D+N
Sbjct: 71 GKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII--DIN 128
Query: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGT 2430
DNAP+F + ++ + EH PG+ +A D D G N SY L SP + FS+ T
Sbjct: 129 DNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNYFSLQLRGRT 187
Query: 2431 LFT----IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
+V +L + A ++L A D G P R + V + D NDH P FT S
Sbjct: 188 DGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSV 247
Query: 2487 YRVAVTEDLPPGSTLLTLEATDAD-GSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAG 2545
YRV+V E++ G+ +L + ATD D G + + +FQL+ ++ GE
Sbjct: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLD---SQTGEVQV 304
Query: 2546 PGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA 2605
G LDFE Y + + D G + + +TV+DVNDN P T
Sbjct: 305 RGS-----------LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITIT 351
Query: 2606 SYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT---LRLA 2662
S ++ E++P G + + D D G +G V + + P F+L+++ G L +
Sbjct: 352 SSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITS 408
Query: 2663 HALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP 2721
LD E + + + A D A V + V D ND+ P FP + S + EN P
Sbjct: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPR 468
Query: 2722 GTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGREAFALNSSTGELRARVPFDYEHTES 2780
G + ++ A+D D+ + YSL + G ++NS+TG L A FDYE
Sbjct: 469 GASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRD 528
Query: 2781 FRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-------VPEGARRGHS 2831
L V A D+G+ LS++V++S+ V +++ P L PA P A G+
Sbjct: 529 LELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYL 588
Query: 2832 LGHVQATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGR 2889
+ V A D+D G + + Y L A+ F + + TG + +
Sbjct: 589 VTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEV--------------RTARALL 634
Query: 2890 TRREAPRELRLEVIARGPLPGSRSATVPVTV------------DITHTALGLAPDLNLLL 2937
R + L + V G P S + T+ V V + A DL+L L
Sbjct: 635 DRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLESLANSETSDLSLYL 694
Query: 2938 VGAVAASLGVVVVLALAALVLGLVR-ARSRKAEAAPGPMS 2976
V AVAA + +V + L L L R +SR +A+ G ++
Sbjct: 695 VVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGLA 734
Score = 186 bits (473), Expect = 3e-46
Identities = 177/644 (27%), Positives = 269/644 (41%), Gaps = 81/644 (12%)
Query: 1036 LAAEGASSPFGLEPQSGWLWVRAALDREA-----------QELYILKVMAVSGSKAELGQ 1084
+ + G + F + P+SG L +DRE EL + + + G
Sbjct: 67 IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG------- 119
Query: 1085 QTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
V V I++ N+++P ED + V+E+ PG A D D G N +Y L
Sbjct: 120 ------VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL 173
Query: 1145 QQLSEDSKAFRIHP---QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAV 1201
+ S R + E+ +LDRE+++++ LL+ DGG P R + V V
Sbjct: 174 SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVV 233
Query: 1202 LDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT---LTG 1258
LD+ND+ P F Q+ + VP+ + GT V + A DPDEG NG ++Y+ +
Sbjct: 234 LDVNDHIPMFTQSV------YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMES 287
Query: 1259 PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL----PS 1314
SE+F L +GE+ L + Y + + D G + ++ + V + P
Sbjct: 288 KASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPE 347
Query: 1315 ARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGAD 1374
+ + E P V +L V + G + + P
Sbjct: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP--------------- 392
Query: 1375 PEGTFALDAASGRLY---LARPLDFEAGPPWR-ALTVRAEGPGGAGARLLRVQVQVQDEN 1430
F L+ G Y +R LD E + LT +G A V + V D+N
Sbjct: 393 ----FKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAET-HVWLNVADDN 447
Query: 1431 EHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRL----LRQEPPVPAL 1486
++ P F + +PEN GA++++ A D D N+ V Y L ++ P +
Sbjct: 448 DNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSK-QNALVTYSLTDDTVQGVPLSSYV 506
Query: 1487 RLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF 1546
+++ TG L A + D E L L V A D + ++ VS +FV D+NDNAP
Sbjct: 507 SINSNTGVLYALQSFDYEQFRDLELRVIARD---SGDPPLSSNVSLSLFVLDQNDNAPEI 563
Query: 1547 ASPSR-------VRL-PEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSS 1597
P+ V L P PG VVA D D G+ A +SYRL + G F +
Sbjct: 564 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEH 623
Query: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVAD 1641
TG + R L + L V DHG PP SAT LTV+VAD
Sbjct: 624 TGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 179 bits (455), Expect = 3e-44
Identities = 170/618 (27%), Positives = 263/618 (42%), Gaps = 43/618 (6%)
Query: 724 ILAGNSPPLFTLDEQSGLLTVAWPLARR------ANSVVQLEIGAEDGGGLQAEPSARVD 777
I++ LF ++ +SG L A + R ++ + +E+ ED + V+
Sbjct: 67 IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG-----VE 121
Query: 778 ISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLF 837
+ I+ P F++ + V E PG + A +P + +L P F
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPD--VGVNSLQSYQLSPNNYF 179
Query: 838 SLD-------AVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
SL A + L LDRE L L G P +RV++ DVND+
Sbjct: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFT---LLAGGGGAFTVDPTT 947
P F V +P N + GT + + A DPD G+N V ++ + + F +D T
Sbjct: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQT 299
Query: 948 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
G V++ L +E+E++ +DGG T+ + VV DV AP +
Sbjct: 300 GEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV--DVNDN--APEITITSSIN 355
Query: 1008 DLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSG---WLWVRAALDREA 1064
+ + GT + + Q D G PF LE G L LDRE
Sbjct: 356 SILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDREL 415
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
+ Y + + A L +T V +++ + N++ P + EN P G S+
Sbjct: 416 VQSYNITLTATDQGSPPLSAETH---VWLNVADDNDNPPVFPHSSYSAYIPENNPRGASI 472
Query: 1125 GRVFATDRDSGPNGRLTYSLQQLSED----SKAFRIHPQTGEVTTLQTLDREQQSSYQLL 1180
V A D DS N +TYSL + S I+ TG + LQ+ D EQ +L
Sbjct: 473 FSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELR 532
Query: 1181 VQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV-PDRVPPGTLVTTL 1239
V +D G PP S+ ++ + VLD NDN+P L + G +++ P PG LVT +
Sbjct: 533 VIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKV 592
Query: 1240 QAKDPDEGENGTILYTL---TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ 1296
A D D G+N + Y L + PG LF++ H+GE+ TA L+ + L ++ D
Sbjct: 593 VAVDKDSGQNAWLSYRLLKASEPG--LFAVGEHTGEVRTARALLDRDALKQSLVVAVQDH 650
Query: 1297 GSPPRSASLQLLVQVLPS 1314
G PP SA++ L V V S
Sbjct: 651 GQPPLSATVTLTVAVADS 668
Score = 164 bits (416), Expect = 1e-39
Identities = 178/651 (27%), Positives = 274/651 (42%), Gaps = 60/651 (9%)
Query: 482 LPEVALPGSFVVRVT---ARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDY 538
+PE GSFV ++ +P + V + T F+++P SG + TA +D
Sbjct: 36 VPEETEKGSFVGNISKDLGLEPRELAKRGVR--IVSRGKTQLFAVNPRSGSLITAGRIDR 93
Query: 539 E-LEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCF 597
E L + + + V V + D+NDN P FQ + E PG F
Sbjct: 94 EELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARF 153
Query: 598 LQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRID-AHSGDVCTTRTLDRDQGPSSFDFT 656
A D D G L SY L S R D A + ++ +LDR++ +
Sbjct: 154 ALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHL-LL 212
Query: 657 VTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQ 714
+TA+DGG K V ++V + D ND+ P F Y S+ GT VL + A DPD+
Sbjct: 213 LTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDE 272
Query: 715 GSHGRLSYHI--LAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEP 772
G +G + Y + + +F LD Q+G + V L ++EI +DGGGL
Sbjct: 273 GINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFT-- 330
Query: 773 SARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGG 831
+ + I++V P + S+ E+ PGT + ++ + G V+ +
Sbjct: 331 TTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNH 390
Query: 832 DPRGLFSLDAVSG---LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVN 888
P F L+ G L T R LDREL+ G PP A V + + D N
Sbjct: 391 LP---FKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDN 447
Query: 889 DNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG------GGAFT 942
DN P FP + +P N G I+++ ALDPDS N+ VT++L +
Sbjct: 448 DNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS 507
Query: 943 VDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDV----------- 991
++ TG + ++ EL + ARD G PP +S+ L + V D
Sbjct: 508 INSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPA 567
Query: 992 ----GTRG--LAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPF 1045
G+ G LAPR P Y V T+V+ V + ++Y L F
Sbjct: 568 LPTDGSTGVELAPRSAEPGYLV---------TKVVAVDKDSGQNAWLSYRLLKASEPGLF 618
Query: 1046 GLEPQSGWL-WVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI 1095
+ +G + RA LDR+A + + V+AV + GQ +ATV +++
Sbjct: 619 AVGEHTGEVRTARALLDRDALKQSL--VVAVQ----DHGQPPLSATVTLTV 663
Score = 149 bits (377), Expect = 3e-35
Identities = 152/560 (27%), Positives = 230/560 (41%), Gaps = 48/560 (8%)
Query: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAF 1902
V ++D ND+AP+F ++V E G A DPD G N +Y L +
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSL 181
Query: 1903 LLE-----PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLST-TVSVTITVRDVNDH 1956
L + EL +LDRE+ ++ ++A+DG P+ V + + V DVNDH
Sbjct: 182 QLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGG--DPIRKGAVPIRVVVLDVNDH 239
Query: 1957 APTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV--- 2013
P F S R+ +P + S+ T L + A D D G N ++Y + +
Sbjct: 240 IPMFTQSVYRVSVPE---NISSGTRVLM-VNATDPDEGINGEVMYSFRNMESKASEIFQL 295
Query: 2014 DSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASS 2073
DS TGE++V S R + I D G T +++ + + P SS
Sbjct: 296 DSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSS 353
Query: 2074 EATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAI-TVRSAEG 2131
+I EN+PPGT I G NG ++ I + F ++ + G + ++
Sbjct: 354 INSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP---FKLEKTYGNYYKLITSRV 410
Query: 2132 LDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEG 2188
LD E+ + L A G+ A T + L + D NDN P F Y A++PE+ P
Sbjct: 411 LDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGA 470
Query: 2189 PLLQVEADDLDQGSGGQISYSLAASQ----PARGLFHVDPTTGTITTTAILDREIWAETR 2244
+ V A D D ++YSL P ++ TG + D E + +
Sbjct: 471 SIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE 530
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIA-------- 2296
L ++A D G P L + +L++ V+D NDN P I P + D G E+A
Sbjct: 531 LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYP---ALPTDGSTGVELAPRSAEPGY 587
Query: 2297 ---QVTGNDVDSGPVLW--YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLA 2351
+V D DSG W Y L + F+VG + G V L + L +
Sbjct: 588 LVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAV 647
Query: 2352 HD---GPHEGRANLTVLVED 2368
D P LTV V D
Sbjct: 648 QDHGQPPLSATVTLTVAVAD 667
Score = 110 bits (276), Expect = 2e-23
Identities = 103/375 (27%), Positives = 156/375 (41%), Gaps = 36/375 (9%)
Query: 2525 GNWGRVFQLEPR-LAEAG---------ESAGPGPRALGCLVLLEPLDFESLTQ------Y 2568
GN + LEPR LA+ G + PR+ G L+ +D E L +
Sbjct: 47 GNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRS-GSLITAGRIDREELCETVSSCFL 105
Query: 2569 NLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASD 2628
N+ + D + V V ++D+NDN P F + V E GA A D
Sbjct: 106 NMELLVEDT-----LKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARD 160
Query: 2629 ADPGPHGLVRFTVSSGDPSGLFELDESSGT-------LRLAHALDCETQARHQLVVQAAD 2681
D G + L + +S P+ F L T L L +LD E +A H L++ A D
Sbjct: 161 PDVGVNSLQSYQLS---PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALD 217
Query: 2682 PAGA-HFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGR 2740
P+ + V DVNDH P F ++ SV EN GT V ++A D D G G
Sbjct: 218 GGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGE 277
Query: 2741 LRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVS 2800
+ YS + E F L+S TGE++ R D+E + + + D G L + T+
Sbjct: 278 VMYSFRNMES--KASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTML 335
Query: 2801 VLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFG 2860
+ V ++ P + + E + G + + D+D G +G V + P F
Sbjct: 336 ITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP-FK 394
Query: 2861 INQTTGALYLRVDSR 2875
+ +T G Y + SR
Sbjct: 395 LEKTYGNYYKLITSR 409
>gi|7706113 protocadherin 12 precursor [Homo sapiens]
Length = 1184
Score = 316 bits (810), Expect = 2e-85
Identities = 236/697 (33%), Positives = 335/697 (48%), Gaps = 71/697 (10%)
Query: 22 LLPLLLLLLLLLGAG----VPGAWGQAGSLDL--QIDEEQPAGTLIGDISAGL------- 68
++ LL LLL LLG G + G + +L + Q+ EE P+GT+IG +S L
Sbjct: 1 MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRR 60
Query: 69 PAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAV-------T 121
AG A ++ A + +D G++ T R LDREQ R + T
Sbjct: 61 QAGAAFQVLQLPQA-------LPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLAT 113
Query: 122 PDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYA 181
D A + V ++V DINDH P FP+ L++ E + TR PL+ A D D G Y
Sbjct: 114 GDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYT 173
Query: 182 LSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALL 241
LS E F L+ GPD T EL+V ELDRE S + L L AYD G+PP+ +L+
Sbjct: 174 LS---PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLV 230
Query: 242 DVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQ-SE 300
V +LD ND++PAF +S + E APG+ ++++ A+D D G NG V + +++ E
Sbjct: 231 KVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPE 290
Query: 301 GDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQP 360
FSIDA TG + L RPLD+E+ +E+ VQARD G +P V + V D NDN P
Sbjct: 291 VLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIP 350
Query: 361 SMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSV 420
S+ V + S VSEA P +A + D D G V+ L GHF L +
Sbjct: 351 SIHVTWASQPS--LVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGN 408
Query: 421 IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPE 480
Y++ LDRE+ Y L + A D G PL A+ + ++D+NDNAP F++ Y
Sbjct: 409 TYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVS 468
Query: 481 PLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYEL 540
E LP ++ + A D D G NG+V+Y + H +ID +G +T SL+YE
Sbjct: 469 -TRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEE 527
Query: 541 EPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQR-----------TFYNAS--- 586
+ V+A D G P LASS +V V+L D NDN P+ + NAS
Sbjct: 528 MAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGH 587
Query: 587 ------LPEGTQP-GT-------------CFLQVTATDADSGPFGLLSYSLGAGLGSSGS 626
P G P GT + A DADSG G YS+ +G + +
Sbjct: 588 LLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSG---NEA 644
Query: 627 PPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG 663
F ++ H+G + T S ++ + D G
Sbjct: 645 HLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQG 681
Score = 220 bits (561), Expect = 2e-56
Identities = 184/590 (31%), Positives = 273/590 (46%), Gaps = 65/590 (11%)
Query: 1593 RLHSSTGALSVVRPLDREQRAEHV-LTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
++ S G LS R LDREQ +V+ D + A + + V D+ND P F +
Sbjct: 78 QVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPK 137
Query: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGV-------LT 1704
E + + E+ T + RA DPD G N TY SE F+LD G L
Sbjct: 138 GEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELI 197
Query: 1705 TLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQ 1764
++ LDRE +L + A D G+PP+ V+V V D ND++P F + L+LE+ E
Sbjct: 198 VVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDA 257
Query: 1765 DPQTLTM-LRASDPDVGANGQLQYRILDGDPS---GAFVLDLASGEFGTMRPLDREVEPA 1820
P TL + L A+DPD G NG++++ + P F +D +G+ RPLD E PA
Sbjct: 258 APGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPA 317
Query: 1821 FQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVE--VPEDVPAGTLLLQLQ 1878
+++ ++ARD G + A + + VLD ND+ P+ V S V E +P + + +
Sbjct: 318 YEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVM 377
Query: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGE---LRTAAALDREQCPSYTFSVSAVDGA 1935
A D D+G NG V +L G F L+ ++G L T A LDREQ P YT ++ A D
Sbjct: 378 ADDLDSGHNGLVHCWLSQ-ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG 436
Query: 1936 AAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGA 1995
PLS ++I + D+ND+AP F S + + P+L L T++A D D G
Sbjct: 437 LQ-PLSAKKQLSIQISDINDNAPVFEKSRYEVSTREN----NLPSLHLITIKAHDADLGI 491
Query: 1996 NASILYRLAGTPPPG-TTVDSYTGEIRVARSPVALGPRDRVLF---IVATDLGRPARSAT 2051
N + YR+ +P +DS TGE+ RS L + F ++A D G+P +++
Sbjct: 492 NGKVSYRIQDSPVAHLVAIDSNTGEVTAQRS---LNYEEMAGFEFQVIAEDSGQPMLASS 548
Query: 2052 GVIIVGLQGEAERGPRFPR-----ASSEATIRENAPPG---TPIVSPRAVHAGGT----- 2098
+ V L + P + + ++ NA G PI +P + GT
Sbjct: 549 VSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPL 608
Query: 2099 ----------------------NGPITYSILSGNEKGTFSIQPSTGAITV 2126
NG YSI SGNE F + P TG + V
Sbjct: 609 ATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 213 bits (541), Expect = 3e-54
Identities = 210/690 (30%), Positives = 302/690 (43%), Gaps = 86/690 (12%)
Query: 1225 QVPDRVPPGTLVTTLQ---AKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIR 1281
QV + VP GT++ L ++ + G L P + + G L T L R
Sbjct: 35 QVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDR 94
Query: 1282 AER-PHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPV-PVVLTV 1339
+ + L + D + A + + +QVL D+ + P P L +
Sbjct: 95 EQLCRQWDPCLVSFDVLATGDLALIHVEIQVL----------DINDHQPRFPKGEQELEI 144
Query: 1340 TAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASG-------RLYLAR 1392
+ + LR L P+ TYTL P FALD G L + +
Sbjct: 145 SESASLRTRIPLDRALDPDTGPNTLHTYTL----SPSEHFALDVIVGPDETKHAELIVVK 200
Query: 1393 PLDFEAGPPWR-ALTVRAEG-PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPE 1450
LD E + LT G P +G L V+V V D N+++PAFA LAL + E+
Sbjct: 201 ELDREIHSFFDLVLTAYDNGNPPKSGTSL--VKVNVLDSNDNSPAFAESSLALEIQEDAA 258
Query: 1451 PGAALYTFRASDADGPGPNSDVRYRLLRQEPP--VPALRLDARTGALSAPRGLDRETTPA 1508
PG L A+D D GPN +V + L + PP + +DA+TG + R LD E PA
Sbjct: 259 PGTLLIKLTATDPD-QGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPA 317
Query: 1509 LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF-----ASPSRVRLPEDQPPGPA 1563
+ V+A D N A + V D NDN P + PS V E P
Sbjct: 318 YEVDVQARDLGPNPI---PAHCKVLIKVLDVNDNIPSIHVTWASQPSLVS--EALPKDSF 372
Query: 1564 ALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTG---ALSVVRPLDREQRAEHVLTVV 1620
V+A D D G V L S GHFRL + G L LDREQ ++ LT++
Sbjct: 373 IALVMADDLDSGHNGLVHCWL-SQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLL 431
Query: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680
A D G P SA + L++ ++D+ND AP F++ Y V RENN P L+T++A D D+G
Sbjct: 432 AQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGI 491
Query: 1681 NGQVTY---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTV 1737
NG+V+Y + ++D +TG +T R+L+ EE V A+D G P + V+V
Sbjct: 492 NGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSV 551
Query: 1738 RVAVEDENDHAP-------TFGSAHLSLEV------------------PEGQD------- 1765
V++ D ND+AP + G A LS+ V P G D
Sbjct: 552 WVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATH 611
Query: 1766 ---PQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGE-FGTMRPLDREVEPAF 1821
P LT + A D D GANG+ Y I G+ + F+L+ +G+ F + + +
Sbjct: 612 SSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEW 671
Query: 1822 QLRIEARDGGQPALSATLLLTVTVLDANDH 1851
+L I D G P L LL V + + DH
Sbjct: 672 ELEIVVEDQGSPPLQTRALLRVMFVTSVDH 701
Score = 198 bits (504), Expect = 6e-50
Identities = 177/587 (30%), Positives = 259/587 (44%), Gaps = 65/587 (11%)
Query: 1381 LDAASGRLYLARPLDFEA-GPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARD 1439
+D+ G L R LD E W V + L+ V++QV D N+H P F +
Sbjct: 79 VDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKG 138
Query: 1440 PLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGA----- 1494
L + E+ + RA D D GPN+ Y L P LD G
Sbjct: 139 EQELEISESASLRTRIPLDRALDPD-TGPNTLHTYTL----SPSEHFALDVIVGPDETKH 193
Query: 1495 --LSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-R 1551
L + LDRE L++ A D N + ++ +V V D NDN+P FA S
Sbjct: 194 AELIVVKELDREIHSFFDLVLTAYD---NGNPPKSGTSLVKVNVLDSNDNSPAFAESSLA 250
Query: 1552 VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGH----FRLHSSTGALSVVRPL 1607
+ + ED PG + + A DPD G V + L+ F + + TG + + RPL
Sbjct: 251 LEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPL 310
Query: 1608 DREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV--LLRENNPPG 1665
D E+ + + V A D G P A + + V DVND P+ S L+ E P
Sbjct: 311 DYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKD 370
Query: 1666 TSLLTLRATDPDVGANGQVTYGGVSSE--SFSLDPDTG---VLTTLRALDREEQEEINLT 1720
+ + + A D D G NG V + +S E F L G +L T LDRE+ + LT
Sbjct: 371 SFIALVMADDLDSGHNGLV-HCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLT 429
Query: 1721 VYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDV 1779
+ AQD+G P + + + D ND+AP F + + E P L ++A D D+
Sbjct: 430 LLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADL 489
Query: 1780 GANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATL 1839
G NG++ YRI D + +D +GE R L+ E F+ ++ A D GQP L++++
Sbjct: 490 GINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSV 549
Query: 1840 LLTVTVLDANDHAPAFPVPAYS--------------------VEVPEDV-PAGT------ 1872
+ V++LDAND+AP P S +E P + PAGT
Sbjct: 550 SVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLA 609
Query: 1873 -------LLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGEL 1911
LL + A D D+GANG Y + +G A F+L P +G+L
Sbjct: 610 THSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQL 656
Score = 179 bits (454), Expect = 4e-44
Identities = 162/562 (28%), Positives = 250/562 (44%), Gaps = 71/562 (12%)
Query: 2150 GAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYS 2209
G A + + + D ND+ PRF + + ES L + A D D G +Y+
Sbjct: 114 GDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYT 173
Query: 2210 LAASQPARGLFHVDPTTGTITTTAI-------LDREIWAETRLVLMATDRGSPALVGSAT 2262
L+ S+ F +D G T LDREI + LVL A D G+P G++
Sbjct: 174 LSPSEH----FALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSL 229
Query: 2263 LTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGP---VLWYVLSPSGP 2318
+ V V+D+NDN P + L + EDA G+ + ++T D D GP V +++ P
Sbjct: 230 VKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPP 289
Query: 2319 Q--DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD-GPHEGRANLTVLVE--DVNDNA 2373
+ D FS+ G+V L PLD+E+ Y++ + A D GP+ A+ VL++ DVNDN
Sbjct: 290 EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNI 349
Query: 2374 PAF--SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTL 2431
P+ + + ++ E P S I V A D DSG NG + L+ F + NG
Sbjct: 350 PSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNT 409
Query: 2432 FTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAV 2491
+ ++ L + + L A+D G +A+ + +Q+ D ND+AP F S Y V+
Sbjct: 410 YMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVST 469
Query: 2492 TEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRAL 2551
E+ P L+T++A DAD + V Y I + ++ E
Sbjct: 470 RENNLPSLHLITIKAHDADLG-INGKVSYRIQDSPVAHLVAIDSNTGE------------ 516
Query: 2552 GCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPP----------- 2600
+ L++E + + V A D GQP +S V V V++LD NDN P
Sbjct: 517 --VTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGK 574
Query: 2601 ----VFTRASY-RVTVPEDTPVGAE------------------LLHVEASDADPGPHGLV 2637
V AS + VP +TP G L + A DAD G +G
Sbjct: 575 ASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEP 634
Query: 2638 RFTVSSGDPSGLFELDESSGTL 2659
+++ SG+ + LF L+ +G L
Sbjct: 635 LYSIRSGNEAHLFILNPHTGQL 656
Score = 178 bits (452), Expect = 7e-44
Identities = 170/597 (28%), Positives = 268/597 (44%), Gaps = 77/597 (12%)
Query: 776 VDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP---PGRLAPVTLSLSGGD 832
V+I ++ P F + + + E + T + + +A +P P L TLS
Sbjct: 121 VEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLS----- 175
Query: 833 PRGLFSLDAVSGLLQT-------LRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLD 885
P F+LD + G +T ++ LDRE+ + +G PP + V+V +
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVL 235
Query: 886 DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG----GAF 941
D NDNSPAF + + + APGT + L A DPD G N V F L F
Sbjct: 236 DSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTF 295
Query: 942 TVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFN 1001
++D TG V L RPL PA+E++++ARD G P +H ++ + V DV N
Sbjct: 296 SIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVND-------N 348
Query: 1002 SPTYRVDLPSGTTAGTQVLQ-------VQAQAPDGGPI-TYHLAAEGASSPFGLEPQSG- 1052
P+ V S + ++ L V A D G H F L+ +G
Sbjct: 349 IPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGN 408
Query: 1053 --WLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPT 1110
L A LDRE Y L ++A L + + + I + N+++P +
Sbjct: 409 TYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKK---QLSIQISDINDNAPVFEKSRY 465
Query: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170
++ EN P + + A D D G NG+++Y +Q S + I TGEVT ++L+
Sbjct: 466 EVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQD-SPVAHLVAIDSNTGEVTAQRSLN 524
Query: 1171 REQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGG--------- 1221
E+ + ++ V +D G P +++ +V V++LD NDN+P +Q + G
Sbjct: 525 YEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNAS 584
Query: 1222 -----LPIQVPDRV-PPGT-------------LVTTLQAKDPDEGENGTILYTL-TGPGS 1261
+PI+ P+ + P GT L+TT+ A+D D G NG LY++ +G +
Sbjct: 585 TGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEA 644
Query: 1262 ELFSLHPHSGELL----TAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPS 1314
LF L+PH+G+L A+ LI +E + L + DQGSPP L V + S
Sbjct: 645 HLFILNPHTGQLFVNVTNASSLIGSE---WELEIVVEDQGSPPLQTRALLRVMFVTS 698
Score = 170 bits (430), Expect = 2e-41
Identities = 173/614 (28%), Positives = 269/614 (43%), Gaps = 96/614 (15%)
Query: 2222 VDPTTGTITTTAILDREI----WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI 2277
VD G ++T LDRE W + G AL+ + + V+D ND++P
Sbjct: 79 VDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIH---VEIQVLDINDHQPRF 135
Query: 2278 PQ-PWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGG----- 2329
P+ EL +SE A L + I D D+GP + Y LSPS + F++ G
Sbjct: 136 PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPS---EHFALDVIVGPDETK 192
Query: 2330 --RVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVM 2384
+ + LD E + L L A+D P G + + V V D NDN+PAF++S +
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 2385 LLEHTPPGSAILSVSATDRDSGANGHISYHLASPA-----DGFSVDPNNGTLFTIVGTVA 2439
+ E PG+ ++ ++ATD D G NG + + L+ D FS+D G ++
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQ---VILRRP 309
Query: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSF--TLSHYRVAVTEDLPP 2497
L ++ + A +V ++ARD G A V +++ D ND+ PS T + V+E LP
Sbjct: 310 LDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPK 369
Query: 2498 GSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLL 2557
S + + A D D H + + +S G F+L+ R G +L
Sbjct: 370 DSFIALVMADDLDSG--HNGLVHCWLSQELGH-FRLK--------------RTNGNTYML 412
Query: 2558 ---EPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPED 2614
LD E +Y LT+ A D+G P S+ +++ + D+NDN PVF ++ Y V+ E+
Sbjct: 413 LTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTREN 472
Query: 2615 TPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ 2674
L+ ++A DAD G +G V + + + L +D ++G + +L+ E A +
Sbjct: 473 NLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFE 532
Query: 2675 LVVQAADPAGAHFALA-PVTIEVQDVNDHGPAFPLNLLSTSVAENQ-------------- 2719
V A D A + V + + D ND+ P +LS A
Sbjct: 533 FQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPI 592
Query: 2720 -------PPGT-------------LVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA-- 2757
P GT L+TT+ A D D+GA G YS+ G EA
Sbjct: 593 ETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSI------RSGNEAHL 646
Query: 2758 FALNSSTGELRARV 2771
F LN TG+L V
Sbjct: 647 FILNPHTGQLFVNV 660
Score = 167 bits (422), Expect = 2e-40
Identities = 187/695 (26%), Positives = 295/695 (42%), Gaps = 88/695 (12%)
Query: 2321 PFSVGRYGGRVSLTGPLDFEQ-CDRYQLQLLAHDGPHEGRANLT---VLVEDVNDNAPAF 2376
P V G +S LD EQ C ++ L++ D G L + V D+ND+ P F
Sbjct: 76 PIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRF 135
Query: 2377 SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVD----PNNGTLF 2432
+ ++ + E + I A D D+G N +Y L SP++ F++D P+
Sbjct: 136 PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-SPSEHFALDVIVGPDETKHA 194
Query: 2433 TIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVT 2492
++ L + D+VL A D+G P ++ + V V + D ND++P+F S + +
Sbjct: 195 ELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQ 254
Query: 2493 EDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALG 2552
ED PG+ L+ L ATD D + V++ + V A+ G+
Sbjct: 255 EDAAPGTLLIKLTATDPDQG-PNGEVEFFLSKHMPPEVLDTFSIDAKTGQ---------- 303
Query: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVF--TRASYRVT 2610
++L PLD+E Y + V A D G P + V + VLDVNDN P T AS
Sbjct: 304 -VILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSL 362
Query: 2611 VPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT--LRLAHA-LDC 2667
V E P + + V A D D G +GLV +S G F L ++G + L +A LD
Sbjct: 363 VSEALPKDSFIALVMADDLDSGHNGLVHCWLSQ--ELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 2668 ETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVT 2726
E ++ L + A D A ++I++ D+ND+ P F + S EN P +
Sbjct: 421 EQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLI 480
Query: 2727 TLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVG 2786
T+ A D D G G++ Y + ++ A++S+TGE+ A+ +YE F V
Sbjct: 481 TIKAHDADLGINGKVSYRIQDSPVA----HLVAIDSNTGEVTAQRSLNYEEMAGFEFQVI 536
Query: 2787 AADAGN--LSASVTVSVLVTGEDEYDPVFLAPAF----------------HFQVPEGARR 2828
A D+G L++SV+V V + ++ P + P H VP
Sbjct: 537 AEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPN 596
Query: 2829 G-------------HS-----LGHVQATDEDGGADGLVLYSLATSSP--YFGINQTTGAL 2868
G HS L + A D D GA+G LYS+ + + F +N TG L
Sbjct: 597 GLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQL 656
Query: 2869 YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALG 2928
++ V + + G+ E E+ +E PL V + H
Sbjct: 657 FVNVTNASSLIGS-----------EWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDS 705
Query: 2929 LAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRA 2963
GA++ S+ V+ LA+ + GL+ A
Sbjct: 706 ARKP------GALSMSMLTVICLAVLLGIFGLILA 734
Score = 164 bits (414), Expect = 2e-39
Identities = 179/681 (26%), Positives = 279/681 (40%), Gaps = 79/681 (11%)
Query: 1863 EVPEDVPAGTLLLQLQ---AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDR 1919
+V E+VP+GT++ +L + G L A ++ G L T LDR
Sbjct: 35 QVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDR 94
Query: 1920 EQ-CPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFST 1978
EQ C + + + D A G L+ + V I V D+NDH P FP L + S S
Sbjct: 95 EQLCRQWDPCLVSFDVLATGDLAL-IHVEIQVLDINDHQPRFPKGEQELEISE---SASL 150
Query: 1979 PTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSP-VALGPRDRV-- 2035
T + RA D D G N Y L+ P +D G + + + DR
Sbjct: 151 RT-RIPLDRALDPDTGPNTLHTYTLS--PSEHFALDVIVGPDETKHAELIVVKELDREIH 207
Query: 2036 ----LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPR 2091
L + A D G P +S T ++ V + + P F +S I+E+A PGT ++
Sbjct: 208 SFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLT 267
Query: 2092 AVHAG-GTNGPITYSI---LSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147
A G NG + + + + TFSI TG + +R LD+E +P + +QA
Sbjct: 268 ATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRP--LDYEKNPAYEVDVQAR 325
Query: 2148 SGGAF---AFTVLTLTLQDANDNAPRF-----LRPHYVAFLPESRPLEGPLLQVEADDLD 2199
G A + + + D NDN P +P V+ E+ P + + V ADDLD
Sbjct: 326 DLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVS---EALPKDSFIALVMADDLD 382
Query: 2200 QGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVG 2259
G G + L+ L + T + T A LDRE W + L L+A D+G L
Sbjct: 383 SGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSA 442
Query: 2260 SATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSPS 2316
L++ + D NDN P + +E+ E+ L + + +D D G + Y + S
Sbjct: 443 KKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDS 502
Query: 2317 GPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPH---EGRANLTVLVEDVNDNA 2373
++ G V+ L++E+ ++ Q++A D ++ V + D NDNA
Sbjct: 503 PVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNA 562
Query: 2374 PAFSQ----------------SLYQVMLLEHTPPGSA------------------ILSVS 2399
P Q S +++ TP G + ++
Sbjct: 563 PEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV 622
Query: 2400 ATDRDSGANGHISYHLAS--PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457
A D DSGANG Y + S A F ++P+ G LF V + +++V+E D
Sbjct: 623 ARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVE--DQ 680
Query: 2458 GAPGRAARATVHVQLQDQNDH 2478
G+P RA + V DH
Sbjct: 681 GSPPLQTRALLRVMFVTSVDH 701
Score = 157 bits (396), Expect = 2e-37
Identities = 177/671 (26%), Positives = 276/671 (41%), Gaps = 68/671 (10%)
Query: 374 QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQ-DSVIYLVCVARRLDR 432
QVSE P G ++ ++S + + + + AL Q DS L+ RRLDR
Sbjct: 35 QVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDR 94
Query: 433 EER-DAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSF 491
E+ ++ + + D + A + V D+ND+ P F + E E++ S
Sbjct: 95 EQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKG----EQELEISESASL 150
Query: 492 VVRVT---ARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITT-------AASLDYELE 541
R+ A DPD G N TY+L+P H F++D G T LD E+
Sbjct: 151 RTRIPLDRALDPDTGPNTLHTYTLSPSEH---FALDVIVGPDETKHAELIVVKELDREIH 207
Query: 542 PQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
L++ A D G PP + ++ V V + D NDN P F + + E PGT +++T
Sbjct: 208 SFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLT 267
Query: 602 ATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD 661
ATD D GP G + + L + F IDA +G V R LD ++ P +++ V A D
Sbjct: 268 ATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNP-AYEVDVQARD 326
Query: 662 GGGLKSMVYVKVFLS--DENDNPPQFYP--REYAASISAQSPPGTAVLRLRAHDPDQGSH 717
G + KV + D NDN P + + +S P + + + A D D G +
Sbjct: 327 LGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHN 386
Query: 718 GRLSYHILAGNSPPLFTLDEQSG----LLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS 773
G + H F L +G LLT A L R L + A+D G
Sbjct: 387 GLV--HCWLSQELGHFRLKRTNGNTYMLLTNA-TLDREQWPKYTLTLLAQDQGLQPLSAK 443
Query: 774 ARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGD 832
++ I I P+FE+ +Y S E+ P + ++AH+ G V+ +
Sbjct: 444 KQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSP 503
Query: 833 PRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSP 892
L ++D+ +G + R L+ E + + SG P + V V L D NDN+P
Sbjct: 504 VAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAP 563
Query: 893 AF----------------------------------PAPEDTVLLPPNTAPGTPIYTLRA 918
PA DT L +++ + T+ A
Sbjct: 564 EVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVA 623
Query: 919 LDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRL-MRPLGPSGGPAHELELEARDGGSP 976
D DSG N +++ +G F ++P TG + + + G ELE+ D GSP
Sbjct: 624 RDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSP 683
Query: 977 PRTSHFRLRVV 987
P + LRV+
Sbjct: 684 PLQTRALLRVM 694
Score = 148 bits (373), Expect = 1e-34
Identities = 158/599 (26%), Positives = 258/599 (43%), Gaps = 65/599 (10%)
Query: 797 FSVPEDVAPGTSVGIV------QAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLR 850
+ V E+V GT +G + + A L L P +D+ GLL T R
Sbjct: 34 YQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALP---IQVDSEEGLLSTGR 90
Query: 851 PLDRELL----GPVL-ELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPP 905
LDRE L P L +V A + A+ V + + D+ND+ P FP E + +
Sbjct: 91 RLDREQLCRQWDPCLVSFDVLATGDL----ALIHVEIQVLDINDHQPRFPKGEQELEISE 146
Query: 906 NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTV---DPTTGHVRLM--RPLGPSG 960
+ + T I RALDPD+G N+ T+TL A V T H L+ + L
Sbjct: 147 SASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKELDREI 206
Query: 961 GPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL 1020
+L L A D G+PP++ ++V V D +P F + +++ GT ++
Sbjct: 207 HSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDN--SPAFAESSLALEIQEDAAPGTLLI 264
Query: 1021 QVQAQAPDGGP-------ITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVM 1073
++ A PD GP ++ H+ E + F ++ ++G + +R LD E Y + V
Sbjct: 265 KLTATDPDQGPNGEVEFFLSKHMPPEVLDT-FSIDAKTGQVILRRPLDYEKNPAYEVDVQ 323
Query: 1074 AVSGSKAELGQQTGTA--TVRVSILNQNEHSPRL----SEDPTFLAVAENQPPGTSVGRV 1127
A +LG A V + +L+ N++ P + + P+ V+E P + + V
Sbjct: 324 A-----RDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSL--VSEALPKDSFIALV 376
Query: 1128 FATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187
A D DSG NG + L Q + R + T + T TLDREQ Y L + QD G
Sbjct: 377 MADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG 436
Query: 1188 SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEG 1247
P S + + + D+NDN+P F ++ + + P + T++A D D G
Sbjct: 437 LQPLSAKKQLSIQISDINDNAPVFEKSR------YEVSTRENNLPSLHLITIKAHDADLG 490
Query: 1248 ENGTILYTL-TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQ 1306
NG + Y + P + L ++ ++GE+ L E + + A D G P ++S+
Sbjct: 491 INGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVS 550
Query: 1307 LLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAP--EPAGVG 1363
+ V +L D + P PV+ A+ + + G + P P G+G
Sbjct: 551 VWVSLL----------DANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLG 599
Score = 139 bits (349), Expect = 6e-32
Identities = 159/644 (24%), Positives = 271/644 (42%), Gaps = 62/644 (9%)
Query: 628 PFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD--GGGLKSMVYVKVFLSDENDNPPQF 685
P ++D+ G + T R LDR+Q +D + + D G ++++V++ + D ND+ P+F
Sbjct: 76 PIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRF 135
Query: 686 YPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTL----DEQSGL 741
E IS + T + RA DPD G + +Y + L + + +
Sbjct: 136 PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAE 195
Query: 742 LTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPE 801
L V L R +S L + A D G ++ V ++++ P F + + E
Sbjct: 196 LIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQE 255
Query: 802 DVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGL---FSLDAVSGLLQTLRPLDRELL 857
D APGT + + A +P G V LS P + FS+DA +G + RPLD E
Sbjct: 256 DAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEK- 314
Query: 858 GPVLELEVRAGS-GVPPAFAVARVRVLLDDVNDNSPAFPAP--EDTVLLPPNTAPGTPIY 914
P E++V+A G P A +V + + DVNDN P+ L+ + I
Sbjct: 315 NPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIA 374
Query: 915 TLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLM---RPLGPSGGPAHELELEAR 971
+ A D DSG N V L+ G F + T G+ ++ L P + L L A+
Sbjct: 375 LVMADDLDSGHNGLV-HCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQ 433
Query: 972 DGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD--- 1028
D G P ++ +L + + D+ AP F Y V ++ ++A D
Sbjct: 434 DQGLQPLSAKKQLSIQISDINDN--APVFEKSRYEVSTRENNLPSLHLITIKAHDADLGI 491
Query: 1029 GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGT 1088
G ++Y + + ++ +G + + +L+ E + +V+A + L +
Sbjct: 492 NGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLAS---S 548
Query: 1089 ATVRVSILNQNEHSPR-----LSEDPTFLAVAENQ----------------PPGTS---- 1123
+V VS+L+ N+++P LS+ L+V N P GT
Sbjct: 549 VSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPL 608
Query: 1124 ---------VGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEV-TTLQTLDREQ 1173
+ + A D DSG NG YS++ +E + F ++P TG++ +
Sbjct: 609 ATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNE-AHLFILNPHTGQLFVNVTNASSLI 667
Query: 1174 QSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGA 1217
S ++L + V+D GSPP T + V + D+ + GA
Sbjct: 668 GSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGA 711
Score = 129 bits (325), Expect = 4e-29
Identities = 139/468 (29%), Positives = 198/468 (42%), Gaps = 62/468 (13%)
Query: 46 SLDLQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTA 104
SL L+I E+ GTL+ ++A P G + +F+S V +ID +G V
Sbjct: 248 SLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILR 307
Query: 105 RVLDREQRDRY------RFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQ--VPEHT 156
R LD E+ Y R P A +V ++V D+ND+ P+ A+ V E
Sbjct: 308 RPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEAL 367
Query: 157 AFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRE 216
+ L A D D+G G LS + FRL+ G L+ LDRE
Sbjct: 368 PKDSFIALVMADDLDSGHNGLVHCWLSQELGH--FRLKRTNGNTYM----LLTNATLDRE 421
Query: 217 NRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQ 276
Y L L A D G P A+ L + + DIND+AP F +SRY E+ P ++
Sbjct: 422 QWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLIT 481
Query: 277 VFASDADAGVNGAVTYEINRRQSEGDGPFS----IDAHTGLLQLERPLDFEQRRVHELVV 332
+ A DAD G+NG V+Y I D P + ID++TG + +R L++E+ E V
Sbjct: 482 IKAHDADLGINGKVSYRIQ------DSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 333 QARDGGAHPELGSAFVTVHVRDANDNQP------------SMTVIFLSADGSPQVSEAAP 380
A D G S V V + DANDN P S++V+ ++ G V P
Sbjct: 536 IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETP 595
Query: 381 PGQ------------------LVARISVSDPDDGDFAHVNVSLEGG-EGH-FALSTQDSV 420
G L+ I D D G S+ G E H F L+
Sbjct: 596 NGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQ 655
Query: 421 IYL-VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF-VLHVTDVN 466
+++ V A L E + L + D GSPPL+ A V+ VT V+
Sbjct: 656 LFVNVTNASSLIGSE---WELEIVVEDQGSPPLQTRALLRVMFVTSVD 700
Score = 44.3 bits (103), Expect = 0.002
Identities = 53/211 (25%), Positives = 81/211 (38%), Gaps = 52/211 (24%)
Query: 84 EGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDG------ATVEVTVRVADIN 137
+ S V +AID ++G V R L+ E+ + F + D ++V V V + D N
Sbjct: 500 QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDAN 559
Query: 138 DHAPAFPQ-----ARAALQVPEHTAFG-TRYPLEP------------------------- 166
D+AP Q +A+L V + + G P+E
Sbjct: 560 DNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLT 619
Query: 167 ---ARDADAGRLGTQGYALSGDGAGETFRLETRPGP---DGTPVPELVVTGELDRENRSH 220
ARDAD+G G Y++ F L G + T L+ S
Sbjct: 620 TIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLI---------GSE 670
Query: 221 YMLQLEAYDGGSPPRRAQALLDVTLLDINDH 251
+ L++ D GSPP + +ALL V + DH
Sbjct: 671 WELEIVVEDQGSPPLQTRALLRVMFVTSVDH 701
>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
[Homo sapiens]
Length = 871
Score = 315 bits (808), Expect = 4e-85
Identities = 224/662 (33%), Positives = 326/662 (49%), Gaps = 42/662 (6%)
Query: 45 GSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGT----DLAIDEHSGV 100
G + + EE GT +G+++ T + +SA+ G +D SG
Sbjct: 29 GQIRYPVPEESQEGTFVGNVAQDFLLDTDS-----LSARRLQVAGEVNQRHFRVDLDSGA 83
Query: 101 VRTARVLDREQRDRYRFTAVTPDGATVE-------VTVRVADINDHAPAFPQARAALQVP 153
+ +DRE + + P E V + D+NDHAP FP+ + L++
Sbjct: 84 LLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIG 143
Query: 154 EHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGEL 213
E G R+PLE A+DAD G Y LS + E F L+ + DG+ VPEL++ L
Sbjct: 144 EAAPPGQRFPLEKAQDADVGSNSISSYRLSSN---EHFALDVKKRSDGSLVPELLLEKPL 200
Query: 214 DRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSP 273
DRE +S Y L L A DGG+PPR A L V++LD+ND+APAF QS Y V ES G
Sbjct: 201 DREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMV 260
Query: 274 VLQVFASDADAGVNGAVTYEINRRQSEG-DGPFSIDAHTGLLQLERPLDFEQRRVHELVV 332
++Q+ ASD D G +G VT+ + + FS+ TG L L PLDFE +E V
Sbjct: 261 LIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDV 320
Query: 333 QARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD 392
+ARDGG+ + V + D NDN P +TV S G+ + E+A PG +VA ISV D
Sbjct: 321 RARDGGSPAMEQHCSLRVDLLDVNDNAPYITV--TSELGT--LPESAEPGTVVALISVQD 376
Query: 393 PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452
PD G V++ + FAL + + + A LDRE + +Y++ VTA+D+G+PPL
Sbjct: 377 PDSGSNGDVSLRIP-DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPL 435
Query: 453 RAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSL 512
L+++DVNDN P+F ++ + +PE PG + + A DPD G N ++YSL
Sbjct: 436 STHRTIFLNISDVNDNPPSFFQRSHEVF-VPENNRPGDLLCSLAASDPDSGLNALISYSL 494
Query: 513 APGAH-----THWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVA 567
+ + + S++P +G + S DYE Q V A D G PPL+S+ TV +
Sbjct: 495 LEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLF 554
Query: 568 LQDVNDNEPQFQR------TFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGL 621
+ D+NDN P R + +LP G +VTA D DSG +SY L L
Sbjct: 555 VLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQL---L 611
Query: 622 GSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDN 681
+ F + ++G+V T + D P + D G V + +S E D
Sbjct: 612 EAPDPSLFAVSRYAGEVRTAVPIPADLPPQK--LVIVVKDSGSPPLSTSVTLLVSLEEDT 669
Query: 682 PP 683
P
Sbjct: 670 HP 671
Score = 277 bits (709), Expect = 1e-73
Identities = 218/630 (34%), Positives = 309/630 (49%), Gaps = 58/630 (9%)
Query: 1487 RLDARTGALSAPRGLDRE-----TTPALLLLVEATDRPANASRRRAARVSARVFVTDEND 1541
R+D +GAL +DRE + ++ L T+ P R A V + D ND
Sbjct: 76 RVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYR-------AEVEIVDVND 128
Query: 1542 NAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH----- 1595
+AP F + + E PPG A+D D+G + SYRL+S + HF L
Sbjct: 129 HAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSS--NEHFALDVKKRS 186
Query: 1596 --SSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQE 1653
S L + +PLDRE+++++ L + A D G+PPRS T L VSV DVND AP FQQ
Sbjct: 187 DGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSS 246
Query: 1654 YSVLLRENNPPGTSLLTLRATDPDVGANGQVT--YGGVSSES----FSLDPDTGVLTTLR 1707
Y + + E+ P G L+ L A+DPD+G +G VT + G + + FSL P TG LT L
Sbjct: 247 YRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLG 306
Query: 1708 ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ 1767
LD E + V A+D GSP H ++RV + D ND+AP +PE +P
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 1768 T-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLA-SGEFG--TMRPLDREVEPAFQL 1823
T + ++ DPD G+NG + RI D P F L A +F T PLDRE + ++ +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPDHLP---FALKSAFRNQFSLVTAGPLDREAKSSYDI 423
Query: 1824 RIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPD 1883
+ A D G P LS + + + D ND+ P+F ++ V VPE+ G LL L A DPD
Sbjct: 424 MVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPD 483
Query: 1884 AGANGHVTYYL------GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAA 1937
+G N ++Y L + L P +G + + D EQ + F V A D
Sbjct: 484 SGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARD-RGN 542
Query: 1938 GPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG---PSFSTPTLA----LATLRAED 1990
PLS+TV+V + V D+ND+AP + LR R RPG P P++ + + A D
Sbjct: 543 PPLSSTVTVRLFVLDLNDNAP----AVLRPR-ARPGSLCPQALPPSVGAGHLITKVTAVD 597
Query: 1991 RDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARS 2049
D+G NA + Y+L P P V Y GE+R A P+ + L IV D G P S
Sbjct: 598 LDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTA-VPIPADLPPQKLVIVVKDSGSPPLS 656
Query: 2050 ATGVIIVGLQGEAERGPRFPRASSEATIRE 2079
+ ++V L E + P P + RE
Sbjct: 657 TSVTLLVSL--EEDTHPVVPDLRESSAPRE 684
Score = 248 bits (632), Expect = 9e-65
Identities = 219/679 (32%), Positives = 307/679 (45%), Gaps = 56/679 (8%)
Query: 1343 EGLRPGSLLGSVAAPEPAGVGALTYTL--VGGADPEGTFALDAASGRLYLARPLDFEAGP 1400
E + G+ +G+VA +L+ V G + F +D SG L + P+D EA
Sbjct: 37 EESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALC 96
Query: 1401 PWRA-----LTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAAL 1455
A L EGP + R +V++ D N+HAP F R L L + E PG
Sbjct: 97 GLSASCIVPLEFVTEGP----LEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRF 152
Query: 1456 YTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAP-----RGLDRETTPALL 1510
+A DAD G NS YRL E AL + R+ P + LDRE
Sbjct: 153 PLEKAQDAD-VGSNSISSYRLSSNEH--FALDVKKRSDGSLVPELLLEKPLDREKQSDYR 209
Query: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVA 1569
L++ A D + R+ RV V D NDNAP F S R+ + E P G + + A
Sbjct: 210 LVLTAVD---GGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNA 266
Query: 1570 RDPDLGEAARVSYRLASGGDGH--------FRLHSSTGALSVVRPLDREQRAEHVLTVVA 1621
DPDLG + V++ + GH F LH +TG L+++ PLD E + V A
Sbjct: 267 SDPDLGPSGNVTFYFS----GHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRA 322
Query: 1622 SDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGAN 1681
D GSP L V + DVND AP L E+ PGT + + DPD G+N
Sbjct: 323 RDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSN 382
Query: 1682 GQVTYGGVSSESFSLDP---DTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVR 1738
G V+ F+L + L T LDRE + ++ V A D G+PP TH T+
Sbjct: 383 GDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIF 442
Query: 1739 VAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL-----DG 1792
+ + D ND+ P+F + VPE P L L ASDPD G N + Y +L D
Sbjct: 443 LNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDV 502
Query: 1793 DPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHA 1852
S L+ +G R D E Q ++ARD G P LS+T+ + + VLD ND+A
Sbjct: 503 SASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNA 562
Query: 1853 PAF------PVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAGTAGAFLLE 1905
PA P +P V AG L+ ++ A D D+G N V+Y L A F +
Sbjct: 563 PAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVS 622
Query: 1906 PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPL 1965
+GE+RTA + + P V V + + PLST+V++ +++ + D P P
Sbjct: 623 RYAGEVRTAVPIPADLPPQKL--VIVVKDSGSPPLSTSVTLLVSLEE--DTHPVVP-DLR 677
Query: 1966 RLRLPRPGPSFSTPTLALA 1984
PR G S T LA++
Sbjct: 678 ESSAPREGESRLTLYLAVS 696
Score = 220 bits (561), Expect = 2e-56
Identities = 198/629 (31%), Positives = 279/629 (44%), Gaps = 61/629 (9%)
Query: 733 FTLDEQSGLLTVAWPLARRA------NSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 786
F +D SG L + P+ R A + +V LE E G L+ R ++ IV
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTE--GPLEMY---RAEVEIVDVNDH 129
Query: 787 PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVS-- 843
P F + Q + E PG + +A + G + + LS + F+LD
Sbjct: 130 APRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRS 186
Query: 844 --GLLQTL---RPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE 898
L+ L +PLDRE + G PP A +RV + DVNDN+PAF
Sbjct: 187 DGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSS 246
Query: 899 DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG----GAFTVDPTTGHVRLMR 954
+ + + G + L A DPD G + VTF F++ PTTG + L+
Sbjct: 247 YRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLG 306
Query: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTT 1014
PL +E ++ ARDGGSP H LRV + DV AP + LP
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDN--APYITVTSELGTLPESAE 364
Query: 1015 AGTQVLQVQAQAPDGGP-------ITYHLAAEGASSPFGLEP---QSGWLWVRAALDREA 1064
GT V + Q PD G I HL PF L+ L LDREA
Sbjct: 365 PGTVVALISVQDPDSGSNGDVSLRIPDHL-------PFALKSAFRNQFSLVTAGPLDREA 417
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
+ Y + V A L T+ ++I + N++ P + + V EN PG +
Sbjct: 418 KSSYDIMVTASDAGNPPLSTHR---TIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLL 474
Query: 1125 GRVFATDRDSGPNGRLTYSL-QQLSEDSKA---FRIHPQTGEVTTLQTLDREQQSSYQLL 1180
+ A+D DSG N ++YSL + + D A ++PQTG V ++ D EQ + Q
Sbjct: 475 CSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFE 534
Query: 1181 VQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQ 1240
VQ +D G+PP S+T TV + VLDLNDN+P L+ G P +P V G L+T +
Sbjct: 535 VQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVT 594
Query: 1241 AKDPDEGENGTILY-TLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP 1299
A D D G N + Y L P LF++ ++GE+ TA P I A+ P L + D GSP
Sbjct: 595 AVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVP-IPADLPPQKLVIVVKDSGSP 653
Query: 1300 PRSASLQLLVQ-------VLPSARLAEPP 1321
P S S+ LLV V+P R + P
Sbjct: 654 PLSTSVTLLVSLEEDTHPVVPDLRESSAP 682
Score = 213 bits (541), Expect = 3e-54
Identities = 181/628 (28%), Positives = 277/628 (44%), Gaps = 41/628 (6%)
Query: 290 VTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQR-RVHELVVQARDGGAHPELGSAFV 348
V E+N+R F +D +G L ++ P+D E + + + L
Sbjct: 66 VAGEVNQRH------FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRA 119
Query: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408
V + D ND+ P F ++ EAAPPGQ D D G + + L
Sbjct: 120 EVEIVDVNDHAPR----FPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 409 EGHFALSTQD----SVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTD 464
E HFAL + S++ + + + LDRE++ Y L +TA D G+PP A + V D
Sbjct: 176 E-HFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLD 234
Query: 465 VNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA---PGAHTHWF 521
VNDNAPAF + YR L E A G ++++ A DPD G +G VT+ + P + F
Sbjct: 235 VNDNAPAFQQSSYRISVL-ESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLF 293
Query: 522 SIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
S+ PT+G +T LD+E E + V A DGG P + ++ V L DVNDN P T
Sbjct: 294 SLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT 353
Query: 582 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTT 641
+LPE +PGT ++ D DSG G +S + L + FR + + T
Sbjct: 354 SELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFR---NQFSLVTA 410
Query: 642 RTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFL--SDENDNPPQFYPREYAASISAQSP 699
LDR+ SS+D VTA D G + +FL SD NDNPP F+ R + + +
Sbjct: 411 GPLDRE-AKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNR 469
Query: 700 PGTAVLRLRAHDPDQGSHGRLSYHILAG-----NSPPLFTLDEQSGLLTVAWPLARRANS 754
PG + L A DPD G + +SY +L ++ +L+ Q+G +
Sbjct: 470 PGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQ 529
Query: 755 VVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPP--IFEQLQYVFSVPEDVAPGTSVG-- 810
+Q E+ A D G + V + ++ P + + + P+ + P G
Sbjct: 530 TLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHL 589
Query: 811 ---IVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRA 867
+ G A V+ L LF++ +G ++T P+ +L L + V+
Sbjct: 590 ITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVK- 648
Query: 868 GSGVPPAFAVARVRVLLDDVNDNSPAFP 895
SG PP + V L++ D P P
Sbjct: 649 DSGSPPLSTSVTLLVSLEE--DTHPVVP 674
Score = 213 bits (541), Expect = 3e-54
Identities = 178/576 (30%), Positives = 274/576 (47%), Gaps = 52/576 (9%)
Query: 2265 VMVIDTNDNRPTIP-QPWELRVSEDALLGSE--IAQVTGNDVDSGPVLWYVLSPSG---- 2317
V ++D ND+ P P Q +L + E A G + + DV S + Y LS +
Sbjct: 121 VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL 180
Query: 2318 PQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAP 2374
S G + L PLD E+ Y+L L A DG P G A L V V DVNDNAP
Sbjct: 181 DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP 240
Query: 2375 AFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDPNNG 2429
AF QS Y++ +LE P G ++ ++A+D D G +G+++++ + FS+ P G
Sbjct: 241 AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG 300
Query: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489
L T++G + + DV ARD G+P ++ V L D ND+AP T++
Sbjct: 301 KL-TLLGPLDFESENYYEFDV--RARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELG 357
Query: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRLAEAGESAGPGP 2548
+ E PG+ + + D D SG+ G V ++ L A +SA
Sbjct: 358 TLPESAEPGTVVALISVQDPD-------------SGSNGDVSLRIPDHLPFALKSAF--- 401
Query: 2549 RALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR 2608
R LV PLD E+ + Y++ V A+D G PP S+ + + + DVNDNPP F + S+
Sbjct: 402 RNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHE 461
Query: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTV-----SSGDPSGLFELDESSGTLRLAH 2663
V VPE+ G L + ASD D G + L+ +++ S L+ +G +
Sbjct: 462 VFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATR 521
Query: 2664 ALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAF------PLNLLSTSVA 2716
+ D E Q VQA D + V + V D+ND+ PA P +L ++
Sbjct: 522 SFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALP 581
Query: 2717 ENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYE 2776
+ G L+T + A+D D+G + Y LLEA P P FA++ GE+R VP +
Sbjct: 582 PSVGAGHLITKVTAVDLDSGYNAWVSYQLLEA-PDP---SLFAVSRYAGEVRTAVPIPAD 637
Query: 2777 HTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPV 2812
+L++ D+G+ S +V++LV+ E++ PV
Sbjct: 638 LPPQ-KLVIVVKDSGSPPLSTSVTLLVSLEEDTHPV 672
Score = 211 bits (537), Expect = 1e-53
Identities = 191/637 (29%), Positives = 275/637 (43%), Gaps = 59/637 (9%)
Query: 47 LDLQIDEEQPAGTLIG-DISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHS-GVVRTA 104
LDL+I E P G + + G+ + Y +S+ E + D +
Sbjct: 138 LDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLE 197
Query: 105 RVLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
+ LDRE++ YR DG T E+ V V D+ND+APAF Q+ + V E
Sbjct: 198 KPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPA 257
Query: 159 GTRYPLEPARDADAGRLGTQGYALSG---DGAGETFRLETRPGPDGTPVPELVVTGELDR 215
G A D D G G + SG D F L G +L + G LD
Sbjct: 258 GMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG-------KLTLLGPLDF 310
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ ++Y + A DGGSP L V LLD+ND+AP + + ES PG+ V
Sbjct: 311 ESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVA 370
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDA---HTGLLQLERPLDFEQRRVHELVV 332
+ D D+G NG V+ I PF++ + + L PLD E + ++++V
Sbjct: 371 LISVQDPDSGSNGDVSLRIPDHL-----PFALKSAFRNQFSLVTAGPLDREAKSSYDIMV 425
Query: 333 QARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD 392
A D G P + +++ D NDN PS F V E PG L+ ++ SD
Sbjct: 426 TASDAGNPPLSTHRTIFLNISDVNDNPPS----FFQRSHEVFVPENNRPGDLLCSLAASD 481
Query: 393 PDDGDFAHVNVSL-------EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
PD G A ++ SL +L+ Q ++ R D E+ V A
Sbjct: 482 PDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVH---ATRSFDYEQTQTLQFEVQAR 538
Query: 446 DSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP-----GSFVVRVTARDP 500
D G+PPL + L V D+NDNAPA R RP L ALP G + +VTA D
Sbjct: 539 DRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDL 598
Query: 501 DQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLAS 560
D G N V+Y L F++ +G + TA + +L PQ +L++V D G PPL++
Sbjct: 599 DSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ-KLVIVVKDSGSPPLST 657
Query: 561 SATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFG----LLSYS 616
S T+ V+L++ D P +++ EG T +L V+ FG LLS
Sbjct: 658 SVTLLVSLEE--DTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKC 715
Query: 617 L-GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSS 652
L GA G + P C TR+ R+ P S
Sbjct: 716 LRGAACGVTCFPA------GTCACLTRSRRREGLPPS 746
Score = 207 bits (527), Expect = 1e-52
Identities = 174/569 (30%), Positives = 262/569 (46%), Gaps = 43/569 (7%)
Query: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHV 2222
D ND+APRF R + E+ P +A D D GS SY L++++ F +
Sbjct: 125 DVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH----FAL 180
Query: 2223 DP---TTGTITTTAIL----DREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRP 2275
D + G++ +L DRE ++ RLVL A D G+P G+A L V V+D NDN P
Sbjct: 181 DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP 240
Query: 2276 TIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGP---VLWYVL--SPSGPQDPFSVGRYGG 2329
Q + + V E A G + Q+ +D D GP V +Y +P ++ FS+ G
Sbjct: 241 AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG 300
Query: 2330 RVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLL 2386
+++L GPLDFE + Y+ + A DG E +L V + DVNDNAP + + L
Sbjct: 301 KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP 360
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446
E PG+ + +S D DSG+NG +S + F++ F++V L +
Sbjct: 361 ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLP-FALKSAFRNQFSLVTAGPLDREAKS 419
Query: 2447 AVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEA 2506
+ D+++ A D G P + T+ + + D ND+ PSF + V V E+ PG L +L A
Sbjct: 420 SYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAA 479
Query: 2507 TDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESA--GPGPRALGCLVLLEPLDFES 2564
+D D S +A + YS+ LEPR + S+ P+ G + D+E
Sbjct: 480 SDPD-SGLNALISYSL----------LEPRNRDVSASSFISLNPQT-GAVHATRSFDYEQ 527
Query: 2565 LTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR------VTVPEDTPVG 2618
V A DRG PP SS V V + VLD+NDN P R R +P G
Sbjct: 528 TQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAG 587
Query: 2619 AELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
+ V A D D G + V + + LF + +G +R A + + + +LV+
Sbjct: 588 HLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ-KLVIV 646
Query: 2679 AADPAGAHFALAPVTIEVQDVNDHGPAFP 2707
D +G+ VT+ V D P P
Sbjct: 647 VKD-SGSPPLSTSVTLLVSLEEDTHPVVP 674
Score = 206 bits (524), Expect = 3e-52
Identities = 184/610 (30%), Positives = 264/610 (43%), Gaps = 51/610 (8%)
Query: 2286 SEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRY 2345
S++ +AQ D DS ++ Q F V G + + P+D E
Sbjct: 39 SQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGL 98
Query: 2346 QLQLLAH-----DGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVS 2399
+ +GP E RA + ++ DVND+AP F + + + E PPG
Sbjct: 99 SASCIVPLEFVTEGPLEMYRAEVEIV--DVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEK 156
Query: 2400 ATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVAL----GHDGSGAVDVVLEAR 2455
A D D G+N SY L+S + F++D + ++V + L + +VL A
Sbjct: 157 AQDADVGSNSISSYRLSSN-EHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAV 215
Query: 2456 DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSH 2515
D G P R+ A + V + D ND+AP+F S YR++V E P G L+ L A+D D S
Sbjct: 216 DGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSG 275
Query: 2516 AAVDYSIISGNWG----RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLT 2571
Y SG+ +F L P G L LL PLDFES Y
Sbjct: 276 NVTFY--FSGHTPDRVRNLFSLHP--------------TTGKLTLLGPLDFESENYYEFD 319
Query: 2572 VAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADP 2631
V A D G P + V +LDVNDN P T S T+PE G + + D D
Sbjct: 320 VRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDS 379
Query: 2632 GPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHF 2687
G +G V + P L + +L A LD E ++ + ++V A+D P H
Sbjct: 380 GSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTH- 438
Query: 2688 ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE 2747
+ + + DVND+ P+F V EN PG L+ +L A D D+G + YSLLE
Sbjct: 439 --RTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLE 496
Query: 2748 AGPGPEGREAF-ALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVT 2804
+F +LN TG + A FDYE T++ + V A D GN LS++VTV + V
Sbjct: 497 PRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVL 556
Query: 2805 GEDEYDPVFLAPAFH------FQVPEGARRGHSLGHVQATDEDGGADGLVLYSL--ATSS 2856
++ P L P +P GH + V A D D G + V Y L A
Sbjct: 557 DLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDP 616
Query: 2857 PYFGINQTTG 2866
F +++ G
Sbjct: 617 SLFAVSRYAG 626
Score = 179 bits (453), Expect = 5e-44
Identities = 170/567 (29%), Positives = 251/567 (44%), Gaps = 50/567 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTG 2122
+ PRFPR + I E APPG +A A + I+ LS NE ++ +
Sbjct: 128 DHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSD 187
Query: 2123 AITVRSA---EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY 2176
V + LD E RLVL A GG L +++ D NDNAP F + Y
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 2177 VAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQP--ARGLFHVDPTTGTITTTAI 2234
+ ES P L+Q+ A D D G G +++ + P R LF + PTTG +T
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGP 307
Query: 2235 LDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWEL-RVSEDALLGS 2293
LD E + A D GSPA+ +L V ++D NDN P I EL + E A G+
Sbjct: 308 LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGT 367
Query: 2294 EIAQVTGNDVDSGPVLWYVLSPSGPQDPFSV-GRYGGRVSL--TGPLDFEQCDRYQLQLL 2350
+A ++ D DSG V PF++ + + SL GPLD E Y + +
Sbjct: 368 VVALISVQDPDSGS-NGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVT 426
Query: 2351 AHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGA 2407
A D P + + + DVNDN P+F Q ++V + E+ PG + S++A+D DSG
Sbjct: 427 ASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGL 486
Query: 2408 NGHISYHLASP------ADGF-SVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
N ISY L P A F S++P G + T + ++ + + ++ARD G P
Sbjct: 487 NALISYSLLEPRNRDVSASSFISLNPQTG---AVHATRSFDYEQTQTLQFEVQARDRGNP 543
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVA--VTEDLPP----GSTLLTLEATDADGSRS 2514
++ TV + + D ND+AP+ R + LPP G + + A D D S
Sbjct: 544 PLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLD-SGY 602
Query: 2515 HAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA 2574
+A V Y ++ +F + R A +A P P L L +
Sbjct: 603 NAWVSYQLLEAPDPSLFAVS-RYAGEVRTAVPIP--------------ADLPPQKLVIVV 647
Query: 2575 ADRGQPPQSSVVPVTVTVLDVNDNPPV 2601
D G PP S+ V + V++ + D PV
Sbjct: 648 KDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 176 bits (447), Expect = 3e-43
Identities = 132/416 (31%), Positives = 201/416 (48%), Gaps = 34/416 (8%)
Query: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR 2529
V++ D NDHAP F + + E PPG +A DAD S++ Y + S
Sbjct: 121 VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVG-SNSISSYRLSSNEH-- 177
Query: 2530 VFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVT 2589
F L+ + G L+L +PLD E + Y L + A D G PP+S +
Sbjct: 178 -FALDVKKRSDGSLVPE-------LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELR 229
Query: 2590 VTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS-- 2647
V+VLDVNDN P F ++SYR++V E P G L+ + ASD D GP G V F S P
Sbjct: 230 VSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV 289
Query: 2648 -GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG-AHFALAPVTIEVQDVNDHGPA 2705
LF L ++G L L LD E++ ++ V+A D A + +++ DVND+ P
Sbjct: 290 RNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPY 349
Query: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765
+ ++ E+ PGT+V + D D+G+ G + + + P FAL S+
Sbjct: 350 ITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLP-------FALKSAFR 402
Query: 2766 ELRARV---PFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHF 2820
+ V P D E S+ ++V A+DAGN LS T+ + ++ ++ P F +
Sbjct: 403 NQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEV 462
Query: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSL-------ATSSPYFGINQTTGALY 2869
VPE R G L + A+D D G + L+ YSL ++S + +N TGA++
Sbjct: 463 FVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVH 518
Score = 164 bits (416), Expect = 1e-39
Identities = 168/606 (27%), Positives = 254/606 (41%), Gaps = 46/606 (7%)
Query: 1902 FLLEPSSGELRTAAALDREQ-CPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
F ++ SG L +DRE C + ++ GPL + + DVNDHAP F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEM-YRAEVEIVDVNDHAPRF 133
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVD-----S 2015
P L L + P P +A+D D G+N+ YRL+ V S
Sbjct: 134 PRQQLDLEIGEAAP----PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGS 189
Query: 2016 YTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEA 2075
E+ + + D L + A D G P RS T + V + + P F ++S
Sbjct: 190 LVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRI 249
Query: 2076 TIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE----KGTFSIQPSTGAITVRSAE 2130
++ E+AP G ++ A G +G +T+ SG+ + FS+ P+TG +T+
Sbjct: 250 SVLESAPAGMVLIQLNASDPDLGPSGNVTF-YFSGHTPDRVRNLFSLHPTTGKLTLLGP- 307
Query: 2131 GLDFEVSPRLRLVLQAESGGAFAF---TVLTLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187
LDFE ++A GG+ A L + L D NDNAP + LPES
Sbjct: 308 -LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247
+ + D D GS G +S + P L ++ T LDRE + +++
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPDHLPF-ALKSAFRNQFSLVTAGPLDREAKSSYDIMV 425
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG 2306
A+D G+P L T+ + + D NDN P+ Q E+ V E+ G + + +D DSG
Sbjct: 426 TASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSG 485
Query: 2307 --PVLWYVLSPSGPQDP-----FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356
++ Y L +D S+ G V T D+EQ Q ++ A D P
Sbjct: 486 LNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPL 545
Query: 2357 EGRANLTVLVEDVNDNAPAFSQ------SLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
+ + V D+NDNAPA + SL L G I V+A D DSG N
Sbjct: 546 SSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAW 605
Query: 2411 ISYHLASPADG--FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468
+SY L D F+V G + T V A +V+ +D G+P + T+
Sbjct: 606 VSYQLLEAPDPSLFAVSRYAGEVRTAVPIPA----DLPPQKLVIVVKDSGSPPLSTSVTL 661
Query: 2469 HVQLQD 2474
V L++
Sbjct: 662 LVSLEE 667
>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
[Homo sapiens]
Length = 938
Score = 315 bits (808), Expect = 4e-85
Identities = 224/662 (33%), Positives = 326/662 (49%), Gaps = 42/662 (6%)
Query: 45 GSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGT----DLAIDEHSGV 100
G + + EE GT +G+++ T + +SA+ G +D SG
Sbjct: 29 GQIRYPVPEESQEGTFVGNVAQDFLLDTDS-----LSARRLQVAGEVNQRHFRVDLDSGA 83
Query: 101 VRTARVLDREQRDRYRFTAVTPDGATVE-------VTVRVADINDHAPAFPQARAALQVP 153
+ +DRE + + P E V + D+NDHAP FP+ + L++
Sbjct: 84 LLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIG 143
Query: 154 EHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGEL 213
E G R+PLE A+DAD G Y LS + E F L+ + DG+ VPEL++ L
Sbjct: 144 EAAPPGQRFPLEKAQDADVGSNSISSYRLSSN---EHFALDVKKRSDGSLVPELLLEKPL 200
Query: 214 DRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSP 273
DRE +S Y L L A DGG+PPR A L V++LD+ND+APAF QS Y V ES G
Sbjct: 201 DREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMV 260
Query: 274 VLQVFASDADAGVNGAVTYEINRRQSEG-DGPFSIDAHTGLLQLERPLDFEQRRVHELVV 332
++Q+ ASD D G +G VT+ + + FS+ TG L L PLDFE +E V
Sbjct: 261 LIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDV 320
Query: 333 QARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD 392
+ARDGG+ + V + D NDN P +TV S G+ + E+A PG +VA ISV D
Sbjct: 321 RARDGGSPAMEQHCSLRVDLLDVNDNAPYITV--TSELGT--LPESAEPGTVVALISVQD 376
Query: 393 PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452
PD G V++ + FAL + + + A LDRE + +Y++ VTA+D+G+PPL
Sbjct: 377 PDSGSNGDVSLRIP-DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPL 435
Query: 453 RAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSL 512
L+++DVNDN P+F ++ + +PE PG + + A DPD G N ++YSL
Sbjct: 436 STHRTIFLNISDVNDNPPSFFQRSHEVF-VPENNRPGDLLCSLAASDPDSGLNALISYSL 494
Query: 513 APGAH-----THWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVA 567
+ + + S++P +G + S DYE Q V A D G PPL+S+ TV +
Sbjct: 495 LEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLF 554
Query: 568 LQDVNDNEPQFQR------TFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGL 621
+ D+NDN P R + +LP G +VTA D DSG +SY L L
Sbjct: 555 VLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQL---L 611
Query: 622 GSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDN 681
+ F + ++G+V T + D P + D G V + +S E D
Sbjct: 612 EAPDPSLFAVSRYAGEVRTAVPIPADLPPQK--LVIVVKDSGSPPLSTSVTLLVSLEEDT 669
Query: 682 PP 683
P
Sbjct: 670 HP 671
Score = 277 bits (709), Expect = 1e-73
Identities = 218/630 (34%), Positives = 309/630 (49%), Gaps = 58/630 (9%)
Query: 1487 RLDARTGALSAPRGLDRE-----TTPALLLLVEATDRPANASRRRAARVSARVFVTDEND 1541
R+D +GAL +DRE + ++ L T+ P R A V + D ND
Sbjct: 76 RVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYR-------AEVEIVDVND 128
Query: 1542 NAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLH----- 1595
+AP F + + E PPG A+D D+G + SYRL+S + HF L
Sbjct: 129 HAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSS--NEHFALDVKKRS 186
Query: 1596 --SSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQE 1653
S L + +PLDRE+++++ L + A D G+PPRS T L VSV DVND AP FQQ
Sbjct: 187 DGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSS 246
Query: 1654 YSVLLRENNPPGTSLLTLRATDPDVGANGQVT--YGGVSSES----FSLDPDTGVLTTLR 1707
Y + + E+ P G L+ L A+DPD+G +G VT + G + + FSL P TG LT L
Sbjct: 247 YRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLG 306
Query: 1708 ALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ 1767
LD E + V A+D GSP H ++RV + D ND+AP +PE +P
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 1768 T-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLA-SGEFG--TMRPLDREVEPAFQL 1823
T + ++ DPD G+NG + RI D P F L A +F T PLDRE + ++ +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPDHLP---FALKSAFRNQFSLVTAGPLDREAKSSYDI 423
Query: 1824 RIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPD 1883
+ A D G P LS + + + D ND+ P+F ++ V VPE+ G LL L A DPD
Sbjct: 424 MVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPD 483
Query: 1884 AGANGHVTYYL------GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAA 1937
+G N ++Y L + L P +G + + D EQ + F V A D
Sbjct: 484 SGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARD-RGN 542
Query: 1938 GPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG---PSFSTPTLA----LATLRAED 1990
PLS+TV+V + V D+ND+AP + LR R RPG P P++ + + A D
Sbjct: 543 PPLSSTVTVRLFVLDLNDNAP----AVLRPR-ARPGSLCPQALPPSVGAGHLITKVTAVD 597
Query: 1991 RDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARS 2049
D+G NA + Y+L P P V Y GE+R A P+ + L IV D G P S
Sbjct: 598 LDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTA-VPIPADLPPQKLVIVVKDSGSPPLS 656
Query: 2050 ATGVIIVGLQGEAERGPRFPRASSEATIRE 2079
+ ++V L E + P P + RE
Sbjct: 657 TSVTLLVSL--EEDTHPVVPDLRESSAPRE 684
Score = 248 bits (632), Expect = 9e-65
Identities = 219/679 (32%), Positives = 307/679 (45%), Gaps = 56/679 (8%)
Query: 1343 EGLRPGSLLGSVAAPEPAGVGALTYTL--VGGADPEGTFALDAASGRLYLARPLDFEAGP 1400
E + G+ +G+VA +L+ V G + F +D SG L + P+D EA
Sbjct: 37 EESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALC 96
Query: 1401 PWRA-----LTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAAL 1455
A L EGP + R +V++ D N+HAP F R L L + E PG
Sbjct: 97 GLSASCIVPLEFVTEGP----LEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRF 152
Query: 1456 YTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAP-----RGLDRETTPALL 1510
+A DAD G NS YRL E AL + R+ P + LDRE
Sbjct: 153 PLEKAQDAD-VGSNSISSYRLSSNEH--FALDVKKRSDGSLVPELLLEKPLDREKQSDYR 209
Query: 1511 LLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVA 1569
L++ A D + R+ RV V D NDNAP F S R+ + E P G + + A
Sbjct: 210 LVLTAVD---GGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNA 266
Query: 1570 RDPDLGEAARVSYRLASGGDGH--------FRLHSSTGALSVVRPLDREQRAEHVLTVVA 1621
DPDLG + V++ + GH F LH +TG L+++ PLD E + V A
Sbjct: 267 SDPDLGPSGNVTFYFS----GHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRA 322
Query: 1622 SDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGAN 1681
D GSP L V + DVND AP L E+ PGT + + DPD G+N
Sbjct: 323 RDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSN 382
Query: 1682 GQVTYGGVSSESFSLDP---DTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVR 1738
G V+ F+L + L T LDRE + ++ V A D G+PP TH T+
Sbjct: 383 GDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIF 442
Query: 1739 VAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL-----DG 1792
+ + D ND+ P+F + VPE P L L ASDPD G N + Y +L D
Sbjct: 443 LNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDV 502
Query: 1793 DPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHA 1852
S L+ +G R D E Q ++ARD G P LS+T+ + + VLD ND+A
Sbjct: 503 SASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNA 562
Query: 1853 PAF------PVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-YLGAGTAGAFLLE 1905
PA P +P V AG L+ ++ A D D+G N V+Y L A F +
Sbjct: 563 PAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVS 622
Query: 1906 PSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPL 1965
+GE+RTA + + P V V + + PLST+V++ +++ + D P P
Sbjct: 623 RYAGEVRTAVPIPADLPPQKL--VIVVKDSGSPPLSTSVTLLVSLEE--DTHPVVP-DLR 677
Query: 1966 RLRLPRPGPSFSTPTLALA 1984
PR G S T LA++
Sbjct: 678 ESSAPREGESRLTLYLAVS 696
Score = 220 bits (561), Expect = 2e-56
Identities = 198/629 (31%), Positives = 279/629 (44%), Gaps = 61/629 (9%)
Query: 733 FTLDEQSGLLTVAWPLARRA------NSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 786
F +D SG L + P+ R A + +V LE E G L+ R ++ IV
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTE--GPLEMY---RAEVEIVDVNDH 129
Query: 787 PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVS-- 843
P F + Q + E PG + +A + G + + LS + F+LD
Sbjct: 130 APRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRS 186
Query: 844 --GLLQTL---RPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE 898
L+ L +PLDRE + G PP A +RV + DVNDN+PAF
Sbjct: 187 DGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSS 246
Query: 899 DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG----GAFTVDPTTGHVRLMR 954
+ + + G + L A DPD G + VTF F++ PTTG + L+
Sbjct: 247 YRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLG 306
Query: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTT 1014
PL +E ++ ARDGGSP H LRV + DV AP + LP
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDN--APYITVTSELGTLPESAE 364
Query: 1015 AGTQVLQVQAQAPDGGP-------ITYHLAAEGASSPFGLEP---QSGWLWVRAALDREA 1064
GT V + Q PD G I HL PF L+ L LDREA
Sbjct: 365 PGTVVALISVQDPDSGSNGDVSLRIPDHL-------PFALKSAFRNQFSLVTAGPLDREA 417
Query: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
+ Y + V A L T+ ++I + N++ P + + V EN PG +
Sbjct: 418 KSSYDIMVTASDAGNPPLSTHR---TIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLL 474
Query: 1125 GRVFATDRDSGPNGRLTYSL-QQLSEDSKA---FRIHPQTGEVTTLQTLDREQQSSYQLL 1180
+ A+D DSG N ++YSL + + D A ++PQTG V ++ D EQ + Q
Sbjct: 475 CSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFE 534
Query: 1181 VQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQ 1240
VQ +D G+PP S+T TV + VLDLNDN+P L+ G P +P V G L+T +
Sbjct: 535 VQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVT 594
Query: 1241 AKDPDEGENGTILY-TLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSP 1299
A D D G N + Y L P LF++ ++GE+ TA P I A+ P L + D GSP
Sbjct: 595 AVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVP-IPADLPPQKLVIVVKDSGSP 653
Query: 1300 PRSASLQLLVQ-------VLPSARLAEPP 1321
P S S+ LLV V+P R + P
Sbjct: 654 PLSTSVTLLVSLEEDTHPVVPDLRESSAP 682
Score = 213 bits (541), Expect = 3e-54
Identities = 181/628 (28%), Positives = 277/628 (44%), Gaps = 41/628 (6%)
Query: 290 VTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQR-RVHELVVQARDGGAHPELGSAFV 348
V E+N+R F +D +G L ++ P+D E + + + L
Sbjct: 66 VAGEVNQRH------FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRA 119
Query: 349 TVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG 408
V + D ND+ P F ++ EAAPPGQ D D G + + L
Sbjct: 120 EVEIVDVNDHAPR----FPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 409 EGHFALSTQD----SVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTD 464
E HFAL + S++ + + + LDRE++ Y L +TA D G+PP A + V D
Sbjct: 176 E-HFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLD 234
Query: 465 VNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA---PGAHTHWF 521
VNDNAPAF + YR L E A G ++++ A DPD G +G VT+ + P + F
Sbjct: 235 VNDNAPAFQQSSYRISVL-ESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLF 293
Query: 522 SIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
S+ PT+G +T LD+E E + V A DGG P + ++ V L DVNDN P T
Sbjct: 294 SLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT 353
Query: 582 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTT 641
+LPE +PGT ++ D DSG G +S + L + FR + + T
Sbjct: 354 SELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFR---NQFSLVTA 410
Query: 642 RTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFL--SDENDNPPQFYPREYAASISAQSP 699
LDR+ SS+D VTA D G + +FL SD NDNPP F+ R + + +
Sbjct: 411 GPLDRE-AKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNR 469
Query: 700 PGTAVLRLRAHDPDQGSHGRLSYHILAG-----NSPPLFTLDEQSGLLTVAWPLARRANS 754
PG + L A DPD G + +SY +L ++ +L+ Q+G +
Sbjct: 470 PGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQ 529
Query: 755 VVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPP--IFEQLQYVFSVPEDVAPGTSVG-- 810
+Q E+ A D G + V + ++ P + + + P+ + P G
Sbjct: 530 TLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHL 589
Query: 811 ---IVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRA 867
+ G A V+ L LF++ +G ++T P+ +L L + V+
Sbjct: 590 ITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVK- 648
Query: 868 GSGVPPAFAVARVRVLLDDVNDNSPAFP 895
SG PP + V L++ D P P
Sbjct: 649 DSGSPPLSTSVTLLVSLEE--DTHPVVP 674
Score = 213 bits (541), Expect = 3e-54
Identities = 178/576 (30%), Positives = 274/576 (47%), Gaps = 52/576 (9%)
Query: 2265 VMVIDTNDNRPTIP-QPWELRVSEDALLGSE--IAQVTGNDVDSGPVLWYVLSPSG---- 2317
V ++D ND+ P P Q +L + E A G + + DV S + Y LS +
Sbjct: 121 VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL 180
Query: 2318 PQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAP 2374
S G + L PLD E+ Y+L L A DG P G A L V V DVNDNAP
Sbjct: 181 DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP 240
Query: 2375 AFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDPNNG 2429
AF QS Y++ +LE P G ++ ++A+D D G +G+++++ + FS+ P G
Sbjct: 241 AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG 300
Query: 2430 TLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRV 2489
L T++G + + DV ARD G+P ++ V L D ND+AP T++
Sbjct: 301 KL-TLLGPLDFESENYYEFDV--RARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELG 357
Query: 2490 AVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRLAEAGESAGPGP 2548
+ E PG+ + + D D SG+ G V ++ L A +SA
Sbjct: 358 TLPESAEPGTVVALISVQDPD-------------SGSNGDVSLRIPDHLPFALKSAF--- 401
Query: 2549 RALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR 2608
R LV PLD E+ + Y++ V A+D G PP S+ + + + DVNDNPP F + S+
Sbjct: 402 RNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHE 461
Query: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTV-----SSGDPSGLFELDESSGTLRLAH 2663
V VPE+ G L + ASD D G + L+ +++ S L+ +G +
Sbjct: 462 VFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATR 521
Query: 2664 ALDCETQARHQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAF------PLNLLSTSVA 2716
+ D E Q VQA D + V + V D+ND+ PA P +L ++
Sbjct: 522 SFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALP 581
Query: 2717 ENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYE 2776
+ G L+T + A+D D+G + Y LLEA P P FA++ GE+R VP +
Sbjct: 582 PSVGAGHLITKVTAVDLDSGYNAWVSYQLLEA-PDP---SLFAVSRYAGEVRTAVPIPAD 637
Query: 2777 HTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPV 2812
+L++ D+G+ S +V++LV+ E++ PV
Sbjct: 638 LPPQ-KLVIVVKDSGSPPLSTSVTLLVSLEEDTHPV 672
Score = 211 bits (537), Expect = 1e-53
Identities = 191/637 (29%), Positives = 275/637 (43%), Gaps = 59/637 (9%)
Query: 47 LDLQIDEEQPAGTLIG-DISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHS-GVVRTA 104
LDL+I E P G + + G+ + Y +S+ E + D +
Sbjct: 138 LDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLE 197
Query: 105 RVLDREQRDRYRFTAVTPDGA------TVEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
+ LDRE++ YR DG T E+ V V D+ND+APAF Q+ + V E
Sbjct: 198 KPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPA 257
Query: 159 GTRYPLEPARDADAGRLGTQGYALSG---DGAGETFRLETRPGPDGTPVPELVVTGELDR 215
G A D D G G + SG D F L G +L + G LD
Sbjct: 258 GMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG-------KLTLLGPLDF 310
Query: 216 ENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
E+ ++Y + A DGGSP L V LLD+ND+AP + + ES PG+ V
Sbjct: 311 ESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVA 370
Query: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDA---HTGLLQLERPLDFEQRRVHELVV 332
+ D D+G NG V+ I PF++ + + L PLD E + ++++V
Sbjct: 371 LISVQDPDSGSNGDVSLRIPDHL-----PFALKSAFRNQFSLVTAGPLDREAKSSYDIMV 425
Query: 333 QARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD 392
A D G P + +++ D NDN PS F V E PG L+ ++ SD
Sbjct: 426 TASDAGNPPLSTHRTIFLNISDVNDNPPS----FFQRSHEVFVPENNRPGDLLCSLAASD 481
Query: 393 PDDGDFAHVNVSL-------EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
PD G A ++ SL +L+ Q ++ R D E+ V A
Sbjct: 482 PDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVH---ATRSFDYEQTQTLQFEVQAR 538
Query: 446 DSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP-----GSFVVRVTARDP 500
D G+PPL + L V D+NDNAPA R RP L ALP G + +VTA D
Sbjct: 539 DRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDL 598
Query: 501 DQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLAS 560
D G N V+Y L F++ +G + TA + +L PQ +L++V D G PPL++
Sbjct: 599 DSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ-KLVIVVKDSGSPPLST 657
Query: 561 SATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFG----LLSYS 616
S T+ V+L++ D P +++ EG T +L V+ FG LLS
Sbjct: 658 SVTLLVSLEE--DTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKC 715
Query: 617 L-GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSS 652
L GA G + P C TR+ R+ P S
Sbjct: 716 LRGAACGVTCFPA------GTCACLTRSRRREGLPPS 746
Score = 207 bits (527), Expect = 1e-52
Identities = 174/569 (30%), Positives = 262/569 (46%), Gaps = 43/569 (7%)
Query: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHV 2222
D ND+APRF R + E+ P +A D D GS SY L++++ F +
Sbjct: 125 DVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH----FAL 180
Query: 2223 DP---TTGTITTTAIL----DREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRP 2275
D + G++ +L DRE ++ RLVL A D G+P G+A L V V+D NDN P
Sbjct: 181 DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP 240
Query: 2276 TIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGP---VLWYVL--SPSGPQDPFSVGRYGG 2329
Q + + V E A G + Q+ +D D GP V +Y +P ++ FS+ G
Sbjct: 241 AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG 300
Query: 2330 RVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLL 2386
+++L GPLDFE + Y+ + A DG E +L V + DVNDNAP + + L
Sbjct: 301 KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP 360
Query: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSG 2446
E PG+ + +S D DSG+NG +S + F++ F++V L +
Sbjct: 361 ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLP-FALKSAFRNQFSLVTAGPLDREAKS 419
Query: 2447 AVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEA 2506
+ D+++ A D G P + T+ + + D ND+ PSF + V V E+ PG L +L A
Sbjct: 420 SYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAA 479
Query: 2507 TDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESA--GPGPRALGCLVLLEPLDFES 2564
+D D S +A + YS+ LEPR + S+ P+ G + D+E
Sbjct: 480 SDPD-SGLNALISYSL----------LEPRNRDVSASSFISLNPQT-GAVHATRSFDYEQ 527
Query: 2565 LTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYR------VTVPEDTPVG 2618
V A DRG PP SS V V + VLD+NDN P R R +P G
Sbjct: 528 TQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAG 587
Query: 2619 AELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
+ V A D D G + V + + LF + +G +R A + + + +LV+
Sbjct: 588 HLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ-KLVIV 646
Query: 2679 AADPAGAHFALAPVTIEVQDVNDHGPAFP 2707
D +G+ VT+ V D P P
Sbjct: 647 VKD-SGSPPLSTSVTLLVSLEEDTHPVVP 674
Score = 206 bits (524), Expect = 3e-52
Identities = 184/610 (30%), Positives = 264/610 (43%), Gaps = 51/610 (8%)
Query: 2286 SEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRY 2345
S++ +AQ D DS ++ Q F V G + + P+D E
Sbjct: 39 SQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGL 98
Query: 2346 QLQLLAH-----DGPHEG-RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVS 2399
+ +GP E RA + ++ DVND+AP F + + + E PPG
Sbjct: 99 SASCIVPLEFVTEGPLEMYRAEVEIV--DVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEK 156
Query: 2400 ATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVAL----GHDGSGAVDVVLEAR 2455
A D D G+N SY L+S + F++D + ++V + L + +VL A
Sbjct: 157 AQDADVGSNSISSYRLSSN-EHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAV 215
Query: 2456 DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSH 2515
D G P R+ A + V + D ND+AP+F S YR++V E P G L+ L A+D D S
Sbjct: 216 DGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSG 275
Query: 2516 AAVDYSIISGNWG----RVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLT 2571
Y SG+ +F L P G L LL PLDFES Y
Sbjct: 276 NVTFY--FSGHTPDRVRNLFSLHP--------------TTGKLTLLGPLDFESENYYEFD 319
Query: 2572 VAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADP 2631
V A D G P + V +LDVNDN P T S T+PE G + + D D
Sbjct: 320 VRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDS 379
Query: 2632 GPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHF 2687
G +G V + P L + +L A LD E ++ + ++V A+D P H
Sbjct: 380 GSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTH- 438
Query: 2688 ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE 2747
+ + + DVND+ P+F V EN PG L+ +L A D D+G + YSLLE
Sbjct: 439 --RTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLE 496
Query: 2748 AGPGPEGREAF-ALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVT 2804
+F +LN TG + A FDYE T++ + V A D GN LS++VTV + V
Sbjct: 497 PRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVL 556
Query: 2805 GEDEYDPVFLAPAFH------FQVPEGARRGHSLGHVQATDEDGGADGLVLYSL--ATSS 2856
++ P L P +P GH + V A D D G + V Y L A
Sbjct: 557 DLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDP 616
Query: 2857 PYFGINQTTG 2866
F +++ G
Sbjct: 617 SLFAVSRYAG 626
Score = 179 bits (453), Expect = 5e-44
Identities = 170/567 (29%), Positives = 251/567 (44%), Gaps = 50/567 (8%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTG 2122
+ PRFPR + I E APPG +A A + I+ LS NE ++ +
Sbjct: 128 DHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSD 187
Query: 2123 AITVRSA---EGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHY 2176
V + LD E RLVL A GG L +++ D NDNAP F + Y
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 2177 VAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQP--ARGLFHVDPTTGTITTTAI 2234
+ ES P L+Q+ A D D G G +++ + P R LF + PTTG +T
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGP 307
Query: 2235 LDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWEL-RVSEDALLGS 2293
LD E + A D GSPA+ +L V ++D NDN P I EL + E A G+
Sbjct: 308 LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGT 367
Query: 2294 EIAQVTGNDVDSGPVLWYVLSPSGPQDPFSV-GRYGGRVSL--TGPLDFEQCDRYQLQLL 2350
+A ++ D DSG V PF++ + + SL GPLD E Y + +
Sbjct: 368 VVALISVQDPDSGS-NGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVT 426
Query: 2351 AHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGA 2407
A D P + + + DVNDN P+F Q ++V + E+ PG + S++A+D DSG
Sbjct: 427 ASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGL 486
Query: 2408 NGHISYHLASP------ADGF-SVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAP 2460
N ISY L P A F S++P G + T + ++ + + ++ARD G P
Sbjct: 487 NALISYSLLEPRNRDVSASSFISLNPQTG---AVHATRSFDYEQTQTLQFEVQARDRGNP 543
Query: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVA--VTEDLPP----GSTLLTLEATDADGSRS 2514
++ TV + + D ND+AP+ R + LPP G + + A D D S
Sbjct: 544 PLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLD-SGY 602
Query: 2515 HAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA 2574
+A V Y ++ +F + R A +A P P L L +
Sbjct: 603 NAWVSYQLLEAPDPSLFAVS-RYAGEVRTAVPIP--------------ADLPPQKLVIVV 647
Query: 2575 ADRGQPPQSSVVPVTVTVLDVNDNPPV 2601
D G PP S+ V + V++ + D PV
Sbjct: 648 KDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 176 bits (447), Expect = 3e-43
Identities = 132/416 (31%), Positives = 201/416 (48%), Gaps = 34/416 (8%)
Query: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR 2529
V++ D NDHAP F + + E PPG +A DAD S++ Y + S
Sbjct: 121 VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVG-SNSISSYRLSSNEH-- 177
Query: 2530 VFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVT 2589
F L+ + G L+L +PLD E + Y L + A D G PP+S +
Sbjct: 178 -FALDVKKRSDGSLVPE-------LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELR 229
Query: 2590 VTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS-- 2647
V+VLDVNDN P F ++SYR++V E P G L+ + ASD D GP G V F S P
Sbjct: 230 VSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV 289
Query: 2648 -GLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG-AHFALAPVTIEVQDVNDHGPA 2705
LF L ++G L L LD E++ ++ V+A D A + +++ DVND+ P
Sbjct: 290 RNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPY 349
Query: 2706 FPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTG 2765
+ ++ E+ PGT+V + D D+G+ G + + + P FAL S+
Sbjct: 350 ITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLP-------FALKSAFR 402
Query: 2766 ELRARV---PFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHF 2820
+ V P D E S+ ++V A+DAGN LS T+ + ++ ++ P F +
Sbjct: 403 NQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEV 462
Query: 2821 QVPEGARRGHSLGHVQATDEDGGADGLVLYSL-------ATSSPYFGINQTTGALY 2869
VPE R G L + A+D D G + L+ YSL ++S + +N TGA++
Sbjct: 463 FVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVH 518
Score = 164 bits (416), Expect = 1e-39
Identities = 168/606 (27%), Positives = 254/606 (41%), Gaps = 46/606 (7%)
Query: 1902 FLLEPSSGELRTAAALDREQ-CPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF 1960
F ++ SG L +DRE C + ++ GPL + + DVNDHAP F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEM-YRAEVEIVDVNDHAPRF 133
Query: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVD-----S 2015
P L L + P P +A+D D G+N+ YRL+ V S
Sbjct: 134 PRQQLDLEIGEAAP----PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGS 189
Query: 2016 YTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEA 2075
E+ + + D L + A D G P RS T + V + + P F ++S
Sbjct: 190 LVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRI 249
Query: 2076 TIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE----KGTFSIQPSTGAITVRSAE 2130
++ E+AP G ++ A G +G +T+ SG+ + FS+ P+TG +T+
Sbjct: 250 SVLESAPAGMVLIQLNASDPDLGPSGNVTF-YFSGHTPDRVRNLFSLHPTTGKLTLLGP- 307
Query: 2131 GLDFEVSPRLRLVLQAESGGAFAF---TVLTLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187
LDFE ++A GG+ A L + L D NDNAP + LPES
Sbjct: 308 -LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVL 2247
+ + D D GS G +S + P L ++ T LDRE + +++
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPDHLPF-ALKSAFRNQFSLVTAGPLDREAKSSYDIMV 425
Query: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG 2306
A+D G+P L T+ + + D NDN P+ Q E+ V E+ G + + +D DSG
Sbjct: 426 TASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSG 485
Query: 2307 --PVLWYVLSPSGPQDP-----FSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPH 2356
++ Y L +D S+ G V T D+EQ Q ++ A D P
Sbjct: 486 LNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPL 545
Query: 2357 EGRANLTVLVEDVNDNAPAFSQ------SLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
+ + V D+NDNAPA + SL L G I V+A D DSG N
Sbjct: 546 SSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAW 605
Query: 2411 ISYHLASPADG--FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468
+SY L D F+V G + T V A +V+ +D G+P + T+
Sbjct: 606 VSYQLLEAPDPSLFAVSRYAGEVRTAVPIPA----DLPPQKLVIVVKDSGSPPLSTSVTL 661
Query: 2469 HVQLQD 2474
V L++
Sbjct: 662 LVSLEE 667
>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
[Homo sapiens]
Length = 936
Score = 314 bits (805), Expect = 8e-85
Identities = 234/674 (34%), Positives = 332/674 (49%), Gaps = 44/674 (6%)
Query: 28 LLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSG 87
L+LL L G+P G A + I EE G+ +G+IS L G A + + S
Sbjct: 17 LVLLCLFFGIPWEAG-ARQISYSIPEELEKGSFVGNISKDL--GLAPRELAERGVRIVSR 73
Query: 88 VGTDL-AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVE-------VTVRVADINDH 139
T L +++ SG + TA +DRE+ V VE + + V DIND+
Sbjct: 74 GRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDN 133
Query: 140 APAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGP 199
AP F +++ E+ A G R+PL A D D G Q Y LS + + F L +
Sbjct: 134 APKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPN---KHFSLRVQSRA 190
Query: 200 DGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSR 259
+G PELV+ LDRE + + L L A DGG P R L+ VT+ D ND+AP F
Sbjct: 191 NGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPE 250
Query: 260 YHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERP 319
Y V E+L G+ +L V A+D D G NG VTY + F ++ +TG +++
Sbjct: 251 YRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISEN 310
Query: 320 LDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAA 379
LD+E+ +E+ +QA DGGA+ L +A V + V D NDN P +T+ L + V+E +
Sbjct: 311 LDYEETGFYEIEIQAEDGGAY--LATAKVLITVEDVNDNSPELTITSLFS----PVTEDS 364
Query: 380 PPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYN 439
P G +VA ++V D D V S+ F L Y + + R LDRE+ +YN
Sbjct: 365 PLGTVVALLNVHDLDSEQNGQVTCSIL-AYLPFKLEKSIDSYYRLVIHRALDREQVSSYN 423
Query: 440 LRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARD 499
+ VTATD GSPPL EA F+L V D+NDN P F + Y +PE G+ + VTA D
Sbjct: 424 ITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTY-IPENNARGASIFSVTALD 482
Query: 500 PDQGTNGQVTYSLAPGA-----HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGG 554
PD N Q+ YSLA + + SI+ +G++ S DYE + Q+ V A+D G
Sbjct: 483 PDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSG 542
Query: 555 LPPLASSATVSVALQDVNDNEPQFQRTFYNA----------SLPEGTQPGTCFLQVTATD 604
PPL+S+ ++S+ + D NDN P+ Y A P +PG +V A D
Sbjct: 543 DPPLSSNVSLSLFVLDQNDNAPEI---LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD 599
Query: 605 ADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT-LDRDQGPSSFDFTVTAVDGG 663
DSG LSY L L +S F + H+G+V T R LDRD S V
Sbjct: 600 RDSGQNAWLSYRL---LKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQP 656
Query: 664 GLKSMVYVKVFLSD 677
L + V + V ++D
Sbjct: 657 PLSATVTLTVAVAD 670
Score = 233 bits (594), Expect = 2e-60
Identities = 199/610 (32%), Positives = 279/610 (45%), Gaps = 61/610 (10%)
Query: 1488 LDARTGALSAPRGLDRETTPA--------LLLLVEATDRPANASRRRAARVSARVFVTDE 1539
L+ R+G+L +DRE A +LVE R + VTD
Sbjct: 81 LNPRSGSLITAGRIDREELCAQSARCVVSFNILVED----------RVKLFGIEIEVTDI 130
Query: 1540 NDNAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSST 1598
NDNAP F + + V++ E+ G A DPD+G + SY+L+ + HF L +
Sbjct: 131 NDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSP--NKHFSLRVQS 188
Query: 1599 GALSVVRP-------LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651
A V P LDRE+ A H L + ASD G P RS T +++V+V D ND AP F
Sbjct: 189 RANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTL 248
Query: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG-----GVSSESFSLDPDTGVLTTL 1706
EY V + EN P GT LLT+ ATD D GANG+VTY F L+ TG +
Sbjct: 249 PEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKIS 308
Query: 1707 RALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP 1766
LD EE + + A+D G+ L V + VED ND++P L V E
Sbjct: 309 ENLDYEETGFYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPL 366
Query: 1767 QT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTM---RPLDREVEPAFQ 1822
T + +L D D NGQ+ IL P F L+ + + + R LDRE ++
Sbjct: 367 GTVVALLNVHDLDSEQNGQVTCSILAYLP---FKLEKSIDSYYRLVIHRALDREQVSSYN 423
Query: 1823 LRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDP 1882
+ + A DGG P LS + V D ND+ P F +Y +PE+ G + + A DP
Sbjct: 424 ITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDP 483
Query: 1883 DAGANGHVTYYL------GAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAA 1936
D+ N + Y L G + + +G L + D EQ V+A D +
Sbjct: 484 DSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASD-SG 542
Query: 1937 AGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG-------PSFSTPTLALATLRAE 1989
PLS+ VS+++ V D ND+AP L LP G P + P + + A
Sbjct: 543 DPPLSSNVSLSLFVLDQNDNAPEI----LYPALPTDGSTGVELAPRSAEPGYLVTKVVAV 598
Query: 1990 DRDAGANASILYRLAGTPPPGT-TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPAR 2048
DRD+G NA + YRL PG V +TGE+R AR+ + + L + D G+P
Sbjct: 599 DRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 658
Query: 2049 SATGVIIVGL 2058
SAT + V +
Sbjct: 659 SATVTLTVAV 668
Score = 211 bits (538), Expect = 7e-54
Identities = 193/617 (31%), Positives = 277/617 (44%), Gaps = 58/617 (9%)
Query: 1691 SESFSLDPDTGVLTTLRALDREE------QEEINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
++ FSL+P +G L T +DREE + ++ + +DR + + + V D
Sbjct: 76 TQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDR-----VKLFGIEIEVTDI 130
Query: 1745 NDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLA 1803
ND+AP F + +L +++ E + A DPDVG N Y++ P+ F L +
Sbjct: 131 NDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQL---SPNKHFSLRVQ 187
Query: 1804 SGEFGTMRP-------LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
S G P LDRE E L + A DGG P S T+L++VTV DAND+AP F
Sbjct: 188 SRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFT 247
Query: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY---YLGAGTAGAFLLEPSSGELRT 1913
+P Y V VPE++P GT LL + A D D GANG VTY L F L +GE++
Sbjct: 248 LPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKI 307
Query: 1914 AAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG 1973
+ LD E+ Y + A DG G T V ITV DVND++P + L +
Sbjct: 308 SENLDYEETGFYEIEIQAEDG---GAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDS 364
Query: 1974 PSFSTPTLALATLRAEDRDAGANASILYRLAGTPP--PGTTVDSYTGEIRVARSPVALGP 2031
P + +A L D D+ N + + P ++DSY + + R+
Sbjct: 365 PLGT----VVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYY-RLVIHRALDREQV 419
Query: 2032 RDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPR 2091
+ + ATD G P S ++ + + P F + S I EN G I S
Sbjct: 420 SSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVT 479
Query: 2092 AVHAGG-TNGPITYSILSGNEKGT-----FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
A+ N I YS+ +G SI TG + + D+E L++ +
Sbjct: 480 ALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVL--YALRSFDYEQFHELQMQVT 537
Query: 2146 AESGG---AFAFTVLTLTLQDANDNAPRFLRPHY-------VAFLPESRPLEGPLLQVEA 2195
A G + L+L + D NDNAP L P V P S + +V A
Sbjct: 538 ASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVA 597
Query: 2196 DDLDQGSGGQISYS-LAASQPARGLFHVDPTTGTI-TTTAILDREIWAETRLVLMATDRG 2253
D D G +SY L AS+P GLF V TG + T A+LDR+ ++ LV+ D G
Sbjct: 598 VDRDSGQNAWLSYRLLKASEP--GLFAVGEHTGEVRTARALLDRDALKQS-LVVAVQDHG 654
Query: 2254 SPALVGSATLTVMVIDT 2270
P L + TLTV V D+
Sbjct: 655 QPPLSATVTLTVAVADS 671
Score = 209 bits (533), Expect = 3e-53
Identities = 183/599 (30%), Positives = 276/599 (46%), Gaps = 26/599 (4%)
Query: 427 ARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEV 485
A R+DREE A + R + + R + + + VTD+NDNAP F + + V
Sbjct: 91 AGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENV 150
Query: 486 ALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGI----ITTAASLDYELE 541
A F + A DPD G N +Y L+P H +G+ + SLD E E
Sbjct: 151 AAGMRFPLP-EAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEE 209
Query: 542 PQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
L++ A+DGG P + + VSV + D NDN P F Y S+PE GT L VT
Sbjct: 210 AIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVT 269
Query: 602 ATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD 661
ATD D G G ++YS L + F+++ ++G++ + LD ++ ++ + A D
Sbjct: 270 ATDRDEGANGEVTYSFRK-LPDTQLLKFQLNKYTGEIKISENLDYEE-TGFYEIEIQAED 327
Query: 662 GGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLS 721
GG + V + + D NDN P+ + ++ SP GT V L HD D +G+++
Sbjct: 328 GGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVT 387
Query: 722 YHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIV 781
ILA L + L + L R S + + A DGG A + +
Sbjct: 388 CSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVA 447
Query: 782 PGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGR-LAPVTLSLSGGDPRGL---- 836
PP F Q+ Y +PE+ A G S+ V A +P + A + SL+ +G+
Sbjct: 448 DINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSS 507
Query: 837 -FSLDAVSGLLQTLRPLDRELLGPVLELEVRAG-SGVPPAFAVARVRVLLDDVNDNSP-- 892
S+++ +G+L LR D E L+++V A SG PP + + + + D NDN+P
Sbjct: 508 YISINSDTGVLYALRSFDYEQFHE-LQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEI 566
Query: 893 AFPA-PED----TVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL-AGGGGAFTVDPT 946
+PA P D L P + PG + + A+D DSG N+ +++ LL A G F V
Sbjct: 567 LYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEH 626
Query: 947 TGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAP--RFNSP 1003
TG VR R L L + +D G PP ++ L V V D + LA F SP
Sbjct: 627 TGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSFESP 685
Score = 196 bits (499), Expect = 2e-49
Identities = 187/626 (29%), Positives = 270/626 (43%), Gaps = 48/626 (7%)
Query: 794 QYVFSVPEDVAPGTSVGIVQAHN--PPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRP 851
Q +S+PE++ G+ VG + P LA + + LFSL+ SG L T
Sbjct: 34 QISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGR 93
Query: 852 LDRE-LLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPG 910
+DRE L V V + + + + D+NDN+P F A V + N A G
Sbjct: 94 IDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAG 153
Query: 911 TPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVR-----LMRPLGPSGGPAHE 965
A+DPD GVNS ++ L + V V+ L L H
Sbjct: 154 MRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHH 213
Query: 966 LELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQ 1025
L L A DGG P R+ + V V D AP F P YRV +P GTQ+L V A
Sbjct: 214 LVLTASDGGDPLRSGTVLVSVTVFDANDN--APVFTLPEYRVSVPENLPVGTQLLTVTAT 271
Query: 1026 APD---GGPITYHLAA--EGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080
D G +TY + F L +G + + LD E Y +++ A G
Sbjct: 272 DRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDG--- 328
Query: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRL 1140
G TA V +++ + N++SP L+ F V E+ P GT V + D DS NG++
Sbjct: 329 --GAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQV 386
Query: 1141 TYSLQQLSEDSKAFRIHPQTGEVTTL---QTLDREQQSSYQLLVQVQDGGSPPRSTTGTV 1197
T S+ F++ L + LDREQ SSY + V DGGSPP ST
Sbjct: 387 TCSILAYLP----FKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHF 442
Query: 1198 HVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT 1257
+ V D+NDN PTF Q S +P+ G + ++ A DPD EN I+Y+L
Sbjct: 443 MLQVADINDNPPTFSQVSYFT------YIPENNARGASIFSVTALDPDSKENAQIIYSLA 496
Query: 1258 G------PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQV 1311
P S S++ +G L + + ++A D G PP S+++ L + V
Sbjct: 497 EDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFV 556
Query: 1312 LPSARLAEPPPDLAERDPAAPVPVVLTV-TAAEGLRPGSLLGSVAAPE-PAGVGA-LTYT 1368
L + P++ PA P V A PG L+ V A + +G A L+Y
Sbjct: 557 LDQ---NDNAPEILY--PALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYR 611
Query: 1369 LVGGADPEGTFALDAASGRLYLARPL 1394
L+ ++P G FA+ +G + AR L
Sbjct: 612 LLKASEP-GLFAVGEHTGEVRTARAL 636
Score = 193 bits (490), Expect = 3e-48
Identities = 175/633 (27%), Positives = 274/633 (43%), Gaps = 59/633 (9%)
Query: 1036 LAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI 1095
+ + G + F L P+SG L +DRE EL V + + + + +
Sbjct: 70 IVSRGRTQLFSLNPRSGSLITAGRIDRE--ELCAQSARCVVSFNILVEDRVKLFGIEIEV 127
Query: 1096 LNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFR 1155
+ N+++P+ + + + EN G A D D G N +Y L +K F
Sbjct: 128 TDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSP----NKHFS 183
Query: 1156 IHPQTG-------EVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNS 1208
+ Q+ E+ +LDRE+++ + L++ DGG P RS T V V V D NDN+
Sbjct: 184 LRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNA 243
Query: 1209 PTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTG-PGSEL--FS 1265
P F + VP+ +P GT + T+ A D DEG NG + Y+ P ++L F
Sbjct: 244 PVFTLPE------YRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQ 297
Query: 1266 LHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL----PSARLAEPP 1321
L+ ++GE+ + L E Y + + A D G+ +A + + V+ + P +
Sbjct: 298 LNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLF 357
Query: 1322 PDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFAL 1381
+ E P V +L V + + G + S+ A P + L D
Sbjct: 358 SPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLP-------FKLEKSID------- 403
Query: 1382 DAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPL 1441
+ RL + R LD E + +G + +QV D N++ P F++
Sbjct: 404 --SYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSY 461
Query: 1442 ALALPENPEPGAALYTFRASDADGPGPNSDVRYRL----LRQEPPVPALRLDARTGALSA 1497
+PEN GA++++ A D D N+ + Y L ++ P + +++ TG L A
Sbjct: 462 FTYIPENNARGASIFSVTALDPDSK-ENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYA 520
Query: 1498 PRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSR------ 1551
R D E L + V A+D + ++ VS +FV D+NDNAP P+
Sbjct: 521 LRSFDYEQFHELQMQVTASD---SGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 577
Query: 1552 -VRL-PEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLD 1608
V L P PG VVA D D G+ A +SYRL + G F + TG + R L
Sbjct: 578 GVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALL 637
Query: 1609 REQRAEHVLTVVASDHGSPPRSATQVLTVSVAD 1641
+ L V DHG PP SAT LTV+VAD
Sbjct: 638 DRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 670
Score = 189 bits (480), Expect = 4e-47
Identities = 199/695 (28%), Positives = 296/695 (42%), Gaps = 76/695 (10%)
Query: 2322 FSVGRYGGRVSLTGPLDFEQ-CDRYQLQLLAHDGPHEGRANL---TVLVEDVNDNAPAFS 2377
FS+ G + G +D E+ C + +++ + E R L + V D+NDNAP F
Sbjct: 79 FSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQ 138
Query: 2378 QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPN---NGTLFT- 2433
V + E+ G A D D G N SY L SP FS+ NG +
Sbjct: 139 AENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQL-SPNKHFSLRVQSRANGVKYPE 197
Query: 2434 IVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
+V +L + +VL A D G P R+ V V + D ND+AP FTL YRV+V E
Sbjct: 198 LVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPE 257
Query: 2494 DLPPGSTLLTLEATDAD-GSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALG 2552
+LP G+ LLT+ ATD D G+ + + FQL + G
Sbjct: 258 NLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLN--------------KYTG 303
Query: 2553 CLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVP 2612
+ + E LD+E Y + + A D G + V +TV DVNDN P T S V
Sbjct: 304 EIKISENLDYEETGFYEIEIQAEDGG--AYLATAKVLITVEDVNDNSPELTITSLFSPVT 361
Query: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
ED+P+G + + D D +G V ++ + P L + +S L + ALD E +
Sbjct: 362 EDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSS 421
Query: 2673 HQLVVQAADPAG------AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVT 2726
+ + V A D AHF L +V D+ND+ P F T + EN G +
Sbjct: 422 YNITVTATDGGSPPLSTEAHFML-----QVADINDNPPTFSQVSYFTYIPENNARGASIF 476
Query: 2727 TLHAIDGDAGAFGRLRYSLLE-AGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLV 2785
++ A+D D+ ++ YSL E G ++NS TG L A FDYE ++ V
Sbjct: 477 SVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQV 536
Query: 2786 GAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-------VPEGARRGHSLGHVQ 2836
A+D+G+ LS++V++S+ V +++ P L PA P A G+ + V
Sbjct: 537 TASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVV 596
Query: 2837 ATDEDGGADGLVLYSL--ATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREA 2894
A D D G + + Y L A+ F + + TG + + R
Sbjct: 597 AVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEV--------------RTARALLDRDAL 642
Query: 2895 PRELRLEVIARGPLPGSRSATVPVTV------------DITHTALGLAPDLNLLLVGAVA 2942
+ L + V G P S + T+ V V A DL L LV AVA
Sbjct: 643 KQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVA 702
Query: 2943 ASLGVVVVLALAALVLGLVR-ARSRKAEAAPGPMS 2976
A V + + L L R +SR +A+ G ++
Sbjct: 703 AVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLT 737
Score = 177 bits (448), Expect = 2e-43
Identities = 173/621 (27%), Positives = 266/621 (42%), Gaps = 49/621 (7%)
Query: 724 ILAGNSPPLFTLDEQSGLLTVAWPL------ARRANSVVQLEIGAEDGGGLQAEPSARVD 777
I++ LF+L+ +SG L A + A+ A VV I ED L ++
Sbjct: 70 IVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFG-----IE 124
Query: 778 ISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLF 837
I + P F+ + E+VA G + +A +P + +L P F
Sbjct: 125 IEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPD--VGVNSLQSYQLSPNKHF 182
Query: 838 SLDAVSGLLQTLRP-------LDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
SL S P LDRE + + G P V V + D NDN
Sbjct: 183 SLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDN 242
Query: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA---FTVDPTT 947
+P F PE V +P N GT + T+ A D D G N VT++ F ++ T
Sbjct: 243 APVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYT 302
Query: 948 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
G +++ L +E+E++A DGG+ T+ ++ + V+DV +P +
Sbjct: 303 GEIKISENLDYEETGFYEIEIQAEDGGAYLATA--KVLITVEDVNDN--SPELTITSLFS 358
Query: 1008 DLPSGTTAGTQVLQVQAQAPDG---GPITYHLAAEGASSPFGLEPQSGWLW---VRAALD 1061
+ + GT V + D G +T + A PF LE + + ALD
Sbjct: 359 PVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAY---LPFKLEKSIDSYYRLVIHRALD 415
Query: 1062 REAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPG 1121
RE Y + V A G L + A + + + N++ P S+ F + EN G
Sbjct: 416 REQVSSYNITVTATDGGSPPLSTE---AHFMLQVADINDNPPTFSQVSYFTYIPENNARG 472
Query: 1122 TSVGRVFATDRDSGPNGRLTYSLQQLSED----SKAFRIHPQTGEVTTLQTLDREQQSSY 1177
S+ V A D DS N ++ YSL + + S I+ TG + L++ D EQ
Sbjct: 473 ASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHEL 532
Query: 1178 QLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV-PDRVPPGTLV 1236
Q+ V D G PP S+ ++ + VLD NDN+P L + G +++ P PG LV
Sbjct: 533 QMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 592
Query: 1237 TTLQAKDPDEGENGTILYTL---TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSA 1293
T + A D D G+N + Y L + PG LF++ H+GE+ TA L+ + L ++
Sbjct: 593 TKVVAVDRDSGQNAWLSYRLLKASEPG--LFAVGEHTGEVRTARALLDRDALKQSLVVAV 650
Query: 1294 HDQGSPPRSASLQLLVQVLPS 1314
D G PP SA++ L V V S
Sbjct: 651 QDHGQPPLSATVTLTVAVADS 671
Score = 176 bits (445), Expect = 4e-43
Identities = 173/613 (28%), Positives = 260/613 (42%), Gaps = 51/613 (8%)
Query: 1897 GTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDH 1956
G F L P SG L TA +DRE+ + + + I V D+ND+
Sbjct: 74 GRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDN 133
Query: 1957 APTFPTSPLRLRLPR---PGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
AP F L +++ G F P A D D G N+ Y+L+ V
Sbjct: 134 APKFQAENLDVKINENVAAGMRFPLP-------EAIDPDVGVNSLQSYQLSPNKHFSLRV 186
Query: 2014 DSYTGEIRVARSPV--ALGPRDRV---LFIVATDLGRPARSATGVIIVGLQGEAERGPRF 2068
S ++ + +L + L + A+D G P RS T ++ V + + P F
Sbjct: 187 QSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVF 246
Query: 2069 PRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSI--LSGNEKGTFSIQPSTGAIT 2125
++ EN P GT +++ A G NG +TYS L + F + TG I
Sbjct: 247 TLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIK 306
Query: 2126 VRSAEGLDFEVSPRLRLVLQAESGGAFAFTV-LTLTLQDANDNAPRFLRPHYVAFLPESR 2184
+ +E LD+E + + +QAE GGA+ T + +T++D NDN+P + + E
Sbjct: 307 I--SENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDS 364
Query: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
PL + + DLD GQ++ S+ A P + +D + A LDRE +
Sbjct: 365 PLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRA-LDREQVSSYN 423
Query: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDV 2303
+ + ATD GSP L A + V D NDN PT Q + + E+ G+ I VT D
Sbjct: 424 ITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDP 483
Query: 2304 DS--GPVLWYVLSPSGPQ-----DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG-- 2354
DS + Y L+ Q S+ G + D+EQ Q+Q+ A D
Sbjct: 484 DSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGD 543
Query: 2355 -PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE----------HTPPGSAILSVSATDR 2403
P +L++ V D NDNAP + LY + + PG + V A DR
Sbjct: 544 PPLSSNVSLSLFVLDQNDNAP---EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDR 600
Query: 2404 DSGANGHISYHL--ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPG 2461
DSG N +SY L AS F+V + G + T AL + +V+ +DHG P
Sbjct: 601 DSGQNAWLSYRLLKASEPGLFAVGEHTGEVRT---ARALLDRDALKQSLVVAVQDHGQPP 657
Query: 2462 RAARATVHVQLQD 2474
+A T+ V + D
Sbjct: 658 LSATVTLTVAVAD 670
Score = 175 bits (443), Expect = 8e-43
Identities = 153/565 (27%), Positives = 254/565 (44%), Gaps = 46/565 (8%)
Query: 2157 LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY-------- 2208
+ + + D NDNAP+F + + E+ EA D D G SY
Sbjct: 123 IEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHF 182
Query: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI 2268
SL A G+ + + + LDRE A LVL A+D G P G+ ++V V
Sbjct: 183 SLRVQSRANGVKYPE-----LVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVF 237
Query: 2269 DTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLS----PSGPQDPFS 2323
D NDN P P + + V E+ +G+++ VT D D G S P F
Sbjct: 238 DANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQ 297
Query: 2324 VGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG-PHEGRANLTVLVEDVNDNAPAFSQSLYQ 2382
+ +Y G + ++ LD+E+ Y++++ A DG + A + + VEDVNDN+P + +
Sbjct: 298 LNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLF 357
Query: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGH 2442
+ E +P G+ + ++ D DS NG ++ + + F ++ + + + +V AL
Sbjct: 358 SPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLP-FKLEKSIDSYYRLVIHRALDR 416
Query: 2443 DGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLL 2502
+ + ++ + A D G+P + A +Q+ D ND+ P+F+ Y + E+ G+++
Sbjct: 417 EQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIF 476
Query: 2503 TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
++ A D D S+ +A + YS+ V L ++ ++ G L L D+
Sbjct: 477 SVTALDPD-SKENAQIIYSLAEDTIQGV-PLSSYISINSDT--------GVLYALRSFDY 526
Query: 2563 ESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELL 2622
E + + V A+D G PP SS V +++ VLD NDN P + +P D G EL
Sbjct: 527 EQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPA----LPTDGSTGVELA 582
Query: 2623 -----------HVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQA 2671
V A D D G + + + + GLF + E +G +R A AL + A
Sbjct: 583 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARAL-LDRDA 641
Query: 2672 RHQLVVQAADPAGAHFALAPVTIEV 2696
Q +V A G A VT+ V
Sbjct: 642 LKQSLVVAVQDHGQPPLSATVTLTV 666
Score = 172 bits (435), Expect = 6e-42
Identities = 171/567 (30%), Positives = 261/567 (46%), Gaps = 63/567 (11%)
Query: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPST 2121
+ P+F + + I EN G P A+ G N +Y LS N+ FS++ +
Sbjct: 132 DNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQ-LSPNKH--FSLRVQS 188
Query: 2122 GAITVRSAE-----GLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLR 2173
A V+ E LD E LVL A GG ++++T+ DANDNAP F
Sbjct: 189 RANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTL 248
Query: 2174 PHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL-FHVDPTTGTITTT 2232
P Y +PE+ P+ LL V A D D+G+ G+++YS + L F ++ TG I +
Sbjct: 249 PEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKIS 308
Query: 2233 AILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRP--TIPQPWELRVSEDAL 2290
LD E + + A D G A + +A + + V D NDN P TI + V+ED+
Sbjct: 309 ENLDYEETGFYEIEIQAEDGG--AYLATAKVLITVEDVNDNSPELTITSLFS-PVTEDSP 365
Query: 2291 LGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQL 2347
LG+ +A + +D+DS G V +L+ + S+ Y R+ + LD EQ Y +
Sbjct: 366 LGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYY-RLVIHRALDREQVSSYNI 424
Query: 2348 QLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD 2404
+ A DG P A+ + V D+NDN P FSQ Y + E+ G++I SV+A D D
Sbjct: 425 TVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPD 484
Query: 2405 SGANGHISYHLAS------PADGF-SVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457
S N I Y LA P + S++ + G L+ + + ++ + + + A D
Sbjct: 485 SKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALR---SFDYEQFHELQMQVTASDS 541
Query: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTE----------DLPPGSTLLTLEAT 2507
G P ++ ++ + + DQND+AP Y T+ PG + + A
Sbjct: 542 GDPPLSSNVSLSLFVLDQNDNAPEIL---YPALPTDGSTGVELAPRSAEPGYLVTKVVAV 598
Query: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
D D S +A + Y ++ + EP L GE G A L D ++L Q
Sbjct: 599 DRD-SGQNAWLSYRLLKAS-------EPGLFAVGEHTGEVRTARALL------DRDALKQ 644
Query: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLD 2594
+L VA D GQPP S+ V +TV V D
Sbjct: 645 -SLVVAVQDHGQPPLSATVTLTVAVAD 670
Score = 158 bits (400), Expect = 7e-38
Identities = 160/565 (28%), Positives = 243/565 (43%), Gaps = 54/565 (9%)
Query: 1841 LTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG 1900
+ + V D ND+AP F V++ E+V AG +A DPD G N +Y L
Sbjct: 123 IEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHF 182
Query: 1901 AFLLEPSSG-----ELRTAAALDREQCPSYTFSVSAVDGAAAGPL-STTVSVTITVRDVN 1954
+ ++ + EL +LDRE+ + ++A DG PL S TV V++TV D N
Sbjct: 183 SLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGG--DPLRSGTVLVSVTVFDAN 240
Query: 1955 DHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILY---RLAGTPPPGT 2011
D+AP F R+ +P P + L T+ A DRD GAN + Y +L T
Sbjct: 241 DNAPVFTLPEYRVSVPENLPVGTQ----LLTVTATDRDEGANGEVTYSFRKLPDTQLLKF 296
Query: 2012 TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRA 2071
++ YTGEI+++ + + I A D G A AT +++ ++ + P
Sbjct: 297 QLNKYTGEIKISENLDYEETGFYEIEIQAEDGG--AYLATAKVLITVEDVNDNSPELTIT 354
Query: 2072 SSEATIRENAPPGTPIVSPRAVHA--GGTNGPITYSILSGNEKGTFSIQPSTGA---ITV 2126
S + + E++P GT +V+ VH NG +T SIL+ F ++ S + + +
Sbjct: 355 SLFSPVTEDSPLGT-VVALLNVHDLDSEQNGQVTCSILAYLP---FKLEKSIDSYYRLVI 410
Query: 2127 RSAEGLDFEVSPRLRLVLQAESGGAFAFTV---LTLTLQDANDNAPRFLRPHYVAFLPES 2183
A LD E + + A GG+ + L + D NDN P F + Y ++PE+
Sbjct: 411 HRA--LDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPEN 468
Query: 2184 RPLEGPLLQVEADDLDQGSGGQISYSLAASQ----PARGLFHVDPTTGTITTTAILDREI 2239
+ V A D D QI YSLA P ++ TG + D E
Sbjct: 469 NARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQ 528
Query: 2240 WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIA--- 2296
+ E ++ + A+D G P L + +L++ V+D NDN P I P + D G E+A
Sbjct: 529 FHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYP---ALPTDGSTGVELAPRS 585
Query: 2297 --------QVTGNDVDSGPVLW--YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ 2346
+V D DSG W Y L + F+VG + G V L +
Sbjct: 586 AEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQS 645
Query: 2347 LQLLAHD---GPHEGRANLTVLVED 2368
L + D P LTV V D
Sbjct: 646 LVVAVQDHGQPPLSATVTLTVAVAD 670
Score = 87.0 bits (214), Expect = 3e-16
Identities = 88/338 (26%), Positives = 138/338 (40%), Gaps = 49/338 (14%)
Query: 46 SLDLQIDEEQPAGTLIG-----DISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGV 100
SL + E+ P GT++ D+ + ++ ++ + + +ID + +
Sbjct: 355 SLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFK------LEKSIDSYYRL 408
Query: 101 VRTARVLDREQRDRYRFTAVTPDGATVEVT------VRVADINDHAPAFPQARAALQVPE 154
V R LDREQ Y T DG + ++ ++VADIND+ P F Q +PE
Sbjct: 409 V-IHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPE 467
Query: 155 HTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV----T 210
+ A G A D D+ Y+L+ D G P+ + T
Sbjct: 468 NNARGASIFSVTALDPDSKENAQIIYSLAEDTI------------QGVPLSSYISINSDT 515
Query: 211 GEL------DRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF-------NQ 257
G L D E +Q+ A D G PP + L + +LD ND+AP +
Sbjct: 516 GVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDG 575
Query: 258 SRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLE 317
S + S PG V +V A D D+G N ++Y + + G F++ HTG ++
Sbjct: 576 STGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPG--LFAVGEHTGEVRTA 633
Query: 318 RPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355
R L LVV +D G P + +TV V D+
Sbjct: 634 RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADS 671
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 149,533,020
Number of Sequences: 37866
Number of extensions: 8362761
Number of successful extensions: 58297
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 21356
Number of HSP's gapped (non-prelim): 4943
length of query: 3298
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3177
effective length of database: 13,665,732
effective search space: 43416030564
effective search space used: 43416030564
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.