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Search of human proteins with 112382257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112382257 InaD-like [Homo sapiens]
(1801 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112382257 InaD-like [Homo sapiens] 3557 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 1200 0.0
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 189 3e-47
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 154 7e-37
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 154 7e-37
gi|45827729 scribble isoform b [Homo sapiens] 149 2e-35
gi|45827731 scribble isoform a [Homo sapiens] 149 2e-35
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 139 2e-32
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 139 2e-32
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 135 4e-31
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 135 4e-31
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 132 4e-30
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 122 4e-27
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 120 2e-26
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 120 2e-26
gi|87196343 PDZ domain containing 2 [Homo sapiens] 119 3e-26
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 119 3e-26
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 114 1e-24
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 114 1e-24
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 113 1e-24
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 112 4e-24
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 111 7e-24
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 110 9e-24
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 110 9e-24
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 110 9e-24
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 107 1e-22
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 107 1e-22
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 106 2e-22
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 106 2e-22
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 104 7e-22
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 3557 bits (9223), Expect = 0.0
Identities = 1801/1801 (100%), Positives = 1801/1801 (100%)
Query: 1 MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQL 60
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQL
Sbjct: 1 MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQL 60
Query: 61 KGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN 120
KGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN
Sbjct: 61 KGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN 120
Query: 121 SVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180
SVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
Sbjct: 121 SVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180
Query: 181 ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPET 240
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPET
Sbjct: 181 ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPET 240
Query: 241 VCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
VCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN
Sbjct: 241 VCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL 360
VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL 360
Query: 361 FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA
Sbjct: 361 FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALF 480
VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALF
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALF 480
Query: 481 LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE 540
LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
Sbjct: 481 LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE 540
Query: 541 VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQP 600
VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQP
Sbjct: 541 VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQP 600
Query: 601 EDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETE 660
EDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETE
Sbjct: 601 EDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETE 660
Query: 661 VDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLV 720
VDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLV
Sbjct: 661 VDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLV 720
Query: 721 ADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEE 780
ADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEE
Sbjct: 721 ADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEE 780
Query: 781 SCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQ 840
SCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQ
Sbjct: 781 SCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQ 840
Query: 841 QKEIEQSKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPLSHIQEATPV 900
QKEIEQSKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPLSHIQEATPV
Sbjct: 841 QKEIEQSKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPLSHIQEATPV 900
Query: 901 PSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPS 960
PSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPS
Sbjct: 901 PSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPS 960
Query: 961 TEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQ 1020
TEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQ
Sbjct: 961 TEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQ 1020
Query: 1021 ATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLG 1080
ATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLG
Sbjct: 1021 ATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLG 1080
Query: 1081 ISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSE 1140
ISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSE
Sbjct: 1081 ISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSE 1140
Query: 1141 AVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMK 1200
AVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMK
Sbjct: 1141 AVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMK 1200
Query: 1201 LPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRS 1260
LPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRS
Sbjct: 1201 LPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRS 1260
Query: 1261 RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR 1320
RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR
Sbjct: 1261 RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Query: 1321 NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM 1380
NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM
Sbjct: 1321 NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM 1380
Query: 1381 KQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI 1440
KQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI
Sbjct: 1381 KQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI 1440
Query: 1441 SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEE 1500
SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEE
Sbjct: 1441 SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEE 1500
Query: 1501 AITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFIS 1560
AITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFIS
Sbjct: 1501 AITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFIS 1560
Query: 1561 DIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWT 1620
DIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWT
Sbjct: 1561 DIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWT 1620
Query: 1621 SARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN 1680
SARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN
Sbjct: 1621 SARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN 1680
Query: 1681 RELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSH 1740
RELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSH
Sbjct: 1681 RELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSH 1740
Query: 1741 ADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEHHPEDTEEQLQMTA 1800
ADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEHHPEDTEEQLQMTA
Sbjct: 1741 ADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEHHPEDTEEQLQMTA 1800
Query: 1801 D 1801
D
Sbjct: 1801 D 1801
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 1200 bits (3105), Expect = 0.0
Identities = 809/2011 (40%), Positives = 1122/2011 (55%), Gaps = 339/2011 (16%)
Query: 6 ATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLN 65
A DK + L +RL+ KL+E+GD + +KLS+ L+SPLF+QIL+LQ S++QLK Q+N
Sbjct: 4 AIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVN 63
Query: 66 HIPSDCSANFDFSR-KGLLVFTDGSITNGNVHRPSNNSTVSGLF-PWTPKLGN----EDF 119
I + ++N +++ L ++ N + NN + L P P + ++F
Sbjct: 64 -IATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEF 122
Query: 120 NSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRL 179
+ +I+ MAQGR +E ++ +P +GGLGFSVV LRS+N G++ IFV+++Q GSVA RD RL
Sbjct: 123 DQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRL 182
Query: 180 KENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR-------EPVHTKS-STSSS 231
KE DQILAIN LDQ I+HQQAI++LQ+ +++L++AR P+ ++S S +S+
Sbjct: 183 KETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAST 242
Query: 232 LNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGD 291
++ + P V W H+E +EL+NDGSGLGFGI+GGK +GV+V+TI+PGG+AD+ GRL +GD
Sbjct: 243 ISAHSNP--VHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGD 300
Query: 292 HILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVAS 351
HILKIG T++ GM+SEQVAQVLR CGN V++++AR + + AP AL + L + +
Sbjct: 301 HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT----APTALGITLSSSPT 356
Query: 352 KGP----------GSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSII 401
P G +S ET++VEL K+ Q LGI I GY+G E SGI+VKSI
Sbjct: 357 STPELRVDASTQKGEES---ETFDVELT-KNVQGLGITIAGYIGDKKL-EPSGIFVKSIT 411
Query: 402 PGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPL 461
SA H+G IQ+ D+I+AVDG N+QGF N VEVLR+ GQ V LTL+RR +
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELM 471
Query: 462 EPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEK------ 515
+ K L A + N + +DE+ + + +N NI E+
Sbjct: 472 SRE-------DVTKDADLSPVNASIIKENYE-KDEDF---LSSTRNTNILPTEEEGYPLL 520
Query: 516 ---LEKVPDSPENE--LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRL 570
+E++ D+ + E L ++W+ ++G +YE++VA + K+S+ L
Sbjct: 521 SAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA----------HVSKFSE-----NSGL 565
Query: 571 GVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP 630
G+ +++ GHH+I S++ GPV G L DELLEVNG+ L G++ ++ V+ LKE+P
Sbjct: 566 GISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
Query: 631 FTLVCCRRLFDD--EASVDEPRRTETSLPET-EVDHNMDVNTEEDDD------------- 674
T+VCCRR ++ +D + L E VD + + E +D
Sbjct: 626 VTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTE 685
Query: 675 ---GELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGL 731
LA+W ++ +EL K KGLGFSILDYQDP+DP +VI+IRSLV G+AE+ G L
Sbjct: 686 EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRL 745
Query: 732 LPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNE 791
LPGDRL+ VN+ L+N+SL EAVE LK P G V +G+ KPL EE + S+ E
Sbjct: 746 LPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEG-----YVSAKE 800
Query: 792 DKTEFSGTIHDINSSLILEAPK--------GFRDEPYFKEELVDEPFLDLGKSFHSQQKE 843
D F H + + + P G D E + P+ S +S Q
Sbjct: 801 DS--FLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQAS 858
Query: 844 IEQ-----------------SKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQD---PS 883
I S ++ E + ++ E L + QD PS
Sbjct: 859 ILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPS 918
Query: 884 PSMELYPLSH--IQEATPVPSVN------------ELHFGTQWLHDNE-PSESQEARTGR 928
+ + P S I + TP ++ E H ++ + E PS ++
Sbjct: 919 VDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKG 978
Query: 929 TVYSQEAQPYGYCPENVMKENFVMESLP-SVPSTEGNSQQGRF--DDLENLNSLAKTSLD 985
+ Y E E VM +N ES ++ +GNS G + + L + ++ +
Sbjct: 979 SEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIH 1038
Query: 986 LGMIPNDVQ---------------------------------GPSLLIDLPVVAQRREQE 1012
G I D + GP + I V A+ E+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITY-VPAEHLEEF 1097
Query: 1013 DLPLYQHQATRVISKA--SAYTGMLSSRYATDTCELPEREEGEGEETP----NFSHWGPP 1066
+ L Q Q+ RV++ S+YTG D ELPEREEGEGEE+ +S+W P
Sbjct: 1098 KISLGQ-QSGRVMALDIFSSYTGR-------DIPELPEREEGEGEESELQNTAYSNWNQP 1149
Query: 1067 RIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1126
R VE++REP+ SLGISIVGG+ + RL NGE ++GIFIK VLEDSPAGK LK GD+I+
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 1127 EVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIP------NVHNKANKITGNQ 1180
EV G+DL++ASH +AVEAI+ AGNPVVF+VQS+ + PR P N++ K N + N
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNP 1269
Query: 1181 -------NQDTQEKKEKRQGTAPPPMKLPPPYKA----------------LTDDSDENEE 1217
N D + + + P +PPP + ++ D D+ E+
Sbjct: 1270 FADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDK-ED 1328
Query: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAA 1277
E ++ + IR+RY L GELH+IELEK +GLGLSLAGNKDRSRMS+F+VGI+P G A
Sbjct: 1329 EFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGK 1388
Query: 1278 DGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPF---- 1333
DGR++I DELLEIN QILYGRSHQNAS+IIK APSKVK++FIRN+DAVNQMAV P
Sbjct: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVE 1448
Query: 1334 PVPSSSP--------------------SSIE---------DQSGTEPISSEEDGSVEVGI 1364
P+PS+S SS + DQ G SEED V I
Sbjct: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVII 1508
Query: 1365 KQLPE-------------------------SESFKLAVSQMKQQKYPTKVSF-----SSQ 1394
K L E + +S +K K K++ SQ
Sbjct: 1509 KSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQ 1568
Query: 1395 EIPLAPASSY----HSTDADFTGYGGFQAPLSV--------------DPATCPIVPGQEM 1436
+P A ++ +S+ + G P S+ DPATCPI+PG E
Sbjct: 1569 AVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCET 1628
Query: 1437 IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496
IEISKGR+GLGLSIVGG DT L AI+IHEVYEEGAA +DGRLWAGDQILEVNG+DLR +
Sbjct: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
Query: 1497 SHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSG 1556
+H+EAI LRQTPQ+VRL +YRDEA Y++EE + ++LQKK G+GLGLSIVGKRN +G
Sbjct: 1689 THDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG 1748
Query: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRA 1616
VF+SDIVKGG AD DGRL+QGDQIL VNGED+RNA+QE VA +LK ++G +
Sbjct: 1749 VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSL--------- 1799
Query: 1617 GSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRT 1676
S+T + S S+ + S+ + + A I GL RT
Sbjct: 1800 SSFTFPLSGSSTSESLESSSKKN---ALASEIQGL-----------------------RT 1833
Query: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
VE+ + +D+LGISIAGG GSPLGD+P+FIAM+ +GVAA+TQKL+VGDRIV+I G +
Sbjct: 1834 VEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 1893
Query: 1737 GLSHADVVNLLKNAYGRIILQVVADTNISAI 1767
G++H VNLLKNA G I +QVVA ++S +
Sbjct: 1894 GMTHTQAVNLLKNASGSIEMQVVAGGDVSVV 1924
Score = 124 bits (312), Expect = 6e-28
Identities = 106/341 (31%), Positives = 165/341 (48%), Gaps = 52/341 (15%)
Query: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501
K GLGLSIVG ++ + + ++ + G A DGRL GDQIL VNG D+RN++ +EA
Sbjct: 1731 KPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEA 1787
Query: 1502 ITALRQTPQKVRLVVYRDEAHYRDEENLE--------------IFPVDLQKKAGRGLGLS 1547
+ AL + + + E+LE + V+++K LG+S
Sbjct: 1788 VAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGIS 1847
Query: 1548 IVGKRNGSG-------VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
I G G G +FI+ + G A +L GD+I+++ G + +L
Sbjct: 1848 IAG---GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLL 1904
Query: 1601 KCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRV 1660
K A G +++++ AG S T Q Q+ A SS TGL +
Sbjct: 1905 KNASGSIEMQVV---AGGDVSVVTGHQ-----QEPASSSLS------FTGLTS------- 1943
Query: 1661 SDPSQKNSGTDMEPRTVEINRELS-DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
S Q + G P+ I E D LG SI GG GSP GD+P+++ + A G A+
Sbjct: 1944 SSIFQDDLGP---PQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDG 2000
Query: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
+LK GD+I+++NGQ L+G++H + V +LK G + L V++
Sbjct: 2001 RLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2041
Score = 117 bits (294), Expect = 8e-26
Identities = 165/728 (22%), Positives = 272/728 (37%), Gaps = 86/728 (11%)
Query: 1103 FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSST 1162
FI+ VL + P G + L +GD++LEV+G+ L +H + V +K V +
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVC-----C 631
Query: 1163 PRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFT 1222
R +P + + EK G + P A+TD EE
Sbjct: 632 RRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEE----- 686
Query: 1223 DQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDR---SRMSIFVVGINPEGPAAADG 1279
++ A + IELEK GLG S+ +D + I + + P G A DG
Sbjct: 687 ---VQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDG 743
Query: 1280 RMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSS 1339
R+ GD L+ +N+ L S + A +K APS + + P
Sbjct: 744 RLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP--------LPLSPEEGY 795
Query: 1340 PSSIEDQSGTEPISSEEDGSVE----------VGIKQ--LPESESFKLAVSQMKQQKYPT 1387
S+ ED P S EE G + VG L + +F+ S Y T
Sbjct: 796 VSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYST 855
Query: 1388 KVSFSSQEIPLAPASSYHSTDADFTGYGGF---QAPLSVDPATCPIVPGQEMIIEI---- 1440
+ S S + S+ D YG P V +C V M +E
Sbjct: 856 QASI---------LSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQ 906
Query: 1441 ------SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQI-------LE 1487
+ + +S+ +N E+ + +W + E
Sbjct: 907 NLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAE 966
Query: 1488 VNGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLG 1545
+ V L +S+ + + L Q+ V+ ++ + E + I K LG
Sbjct: 967 LPSV-LPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINI------AKGNSSLG 1019
Query: 1546 LSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQG 1605
+++ ++G G+ + I+ GGA DGR+ GD ILS+N E + + +L+
Sbjct: 1020 MTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR-RHS 1078
Query: 1606 LV--QLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDP 1663
L+ ++I + A + + G + + + + G S+
Sbjct: 1079 LIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESEL 1138
Query: 1664 SQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL----GDIP--VFIAMIQASGVAAR 1717
+PR VE+ RE S +LGISI GGRG G++ +FI + A +
Sbjct: 1139 QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGK 1198
Query: 1718 TQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTN---ISAIAAQLENM 1774
LK GDRIV ++G L SH V ++ A ++ V + N S + + L N+
Sbjct: 1199 NGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNL 1258
Query: 1775 STGYHLGS 1782
Y+ S
Sbjct: 1259 YPKYNFSS 1266
Score = 117 bits (292), Expect = 1e-25
Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 25/328 (7%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
I++++ GLG S+V R+ +FV D+ G +AD D RL + DQIL +N +
Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDT----GVFVSDIVKGGIADADGRLMQGDQILMVNGEDV- 1780
Query: 195 QNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELIND 254
+N + + ALL+ + GSL P+ + SSTS SL ++ + ++ + +
Sbjct: 1781 RNATQEAVAALLKVSEGSLSSFTF--PL-SGSSTSESLESSSKKNALA-SEIQGLRTVEM 1836
Query: 255 GSG----LGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
G LG I GG S + + + P G+A + +L+ GD I+ I GT+ +GMT
Sbjct: 1837 KKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMT 1896
Query: 306 SEQVAQVLRNCGNSVRMLVARDPAGDISVTP---PAPAALPVALPTVASKGPGSDSSLFE 362
Q +L+N S+ M V GD+SV PA+ ++ + S D
Sbjct: 1897 HTQAVNLLKNASGSIEMQVVA--GGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP 1954
Query: 363 TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
+ + LG IVG G+ H G+ IYVK++ AA +G ++ D+I+AV+
Sbjct: 1955 QCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVN 2012
Query: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLV 450
G +++G + + V +L+ V L ++
Sbjct: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 114 bits (285), Expect = 9e-25
Identities = 161/704 (22%), Positives = 291/704 (41%), Gaps = 97/704 (13%)
Query: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
++ I++E+ +G LG S+ + ++ ++ +F+ + P A +D RL+ D++L IN
Sbjct: 1347 ELHMIELEKGHSG-LGLSLAGNKDRS--RMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAREP-------------VHTKSSTSSSLNDTTL 237
L SHQ A ++++ +++I R V S S +L +
Sbjct: 1404 QIL-YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 238 PETVC----------WGHVEEVELINDGSGLGFGIVGGKT-SGVVVRTIVPGGLADRDGR 286
TV + +V+ +EL D GLG I T SGV+++++ G+A DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 287 LQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV-ARDP--------AGDIS---- 333
L+ GD IL + V G E+ +L+ +V++ + A +P AG S
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
Query: 334 ------VTPPAPAALPVAL--------PTVASKGPGSDSSLFETYNVELVRKDGQSLGIR 379
+ P + + P ++ P + + P + + + K LG+
Sbjct: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1642
Query: 380 IVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLR 439
IVG T I + + AA +G + D+I+ V+G++++ + + + VLR
Sbjct: 1643 IVGGSDTL----LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
Query: 440 NAGQVVHLTLVRRKT--------SSSTSPLEPPSDRG---TVVEPLKPPALFLTGAVETE 488
Q V LTL R + + T L+ +G ++V +F++ V+
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGG 1758
Query: 489 -TNVDGE----DEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMV 543
+ DG D+ + + ++N +A+ L KV E L S L G +
Sbjct: 1759 IADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS---EGSLSSFTFPLSGSSTSESL 1815
Query: 544 ATLDTQIADDAELQKYS----KLLPIHTLRL----GVEVDSFDGHHYISSIVSGGPVDTL 595
+ + A +E+Q K P +L + GV D +I+ + G
Sbjct: 1816 ESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQT 1875
Query: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETS 655
L+ D ++ + G G + +AV+ LK + + + + SV + E +
Sbjct: 1876 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM---QVVAGGDVSVVTGHQQEPA 1932
Query: 656 LPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD-YQDPLDPTRSVI 714
+ +DD G P+ K + L + GLGFSI+ Y P I
Sbjct: 1933 SSSLSFTGLTSSSIFQDDLGP-----PQCKSITLERGPDGLGFSIVGGYGSPHGDLP--I 1985
Query: 715 VIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
++++ A G A G L GD++++VN L+ + EAV ILK
Sbjct: 1986 YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029
Score = 96.7 bits (239), Expect = 2e-19
Identities = 129/600 (21%), Positives = 231/600 (38%), Gaps = 135/600 (22%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
+ ++++++ + GGLG ++ S+ + +K + VA D RLK DQILA++
Sbjct: 1479 KNVQHLELPKDQ-GGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVD 1533
Query: 190 HT-----PLDQNIS------------------HQQAI------ALLQQTTGSLRLIVAR- 219
P+++ IS QA+ A ++ S L+V +
Sbjct: 1534 DEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQS 1593
Query: 220 -----EPVHTKSSTSSSLNDTTLPET--VCWGHVEEVELINDGSGLGFGIVGGKTS---G 269
E + S +S+ + P T + G +E+ +GLG IVGG +
Sbjct: 1594 GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGA 1653
Query: 270 VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPA 329
+++ + G A +DGRL GD IL++ G +++ T ++ VLR VR+ + RD A
Sbjct: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
Query: 330 GDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHT 389
P + + +T +EL +K G+ LG+ IVG
Sbjct: 1714 ------------------------PYKEEEVCDTLTIELQKKPGKGLGLSIVG------K 1743
Query: 390 GEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLR-NAGQVVHLT 448
+G++V I+ G A +G + D+I+ V+G +++ V +L+ + G + T
Sbjct: 1744 RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFT 1803
Query: 449 LVRRKTSSSTSPLEPPSDR----------------------------GTVVEPLKPPALF 480
+S+S S LE S + G V PL +F
Sbjct: 1804 FPLSGSSTSES-LESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIF 1862
Query: 481 LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE 540
+ T + + +RI T+ + + + + V + + G D
Sbjct: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVS 1922
Query: 541 VMVA---------------TLDTQIADDAELQKYSKLLPIHTLRLGVE------VDSFDG 579
V+ T + DD + + TL G + V +
Sbjct: 1923 VVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSI----TLERGPDGLGFSIVGGYGS 1978
Query: 580 HH-----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
H Y+ ++ + G G L+ D+++ VNG L G + EAV+ LK TL+
Sbjct: 1979 PHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 96.3 bits (238), Expect = 2e-19
Identities = 72/246 (29%), Positives = 122/246 (49%), Gaps = 21/246 (8%)
Query: 99 SNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIE---YIDIERPSTGGLGFSVVALRSQ 155
S S S FP + +E S ++ A +I+ +++++ T LG S+
Sbjct: 1795 SEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGS 1854
Query: 156 NLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215
LG V IF+ + P VA + Q+L+ D+I+ I T + ++H QA+ LL+ +GS+ +
Sbjct: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE-GMTHTQAVNLLKNASGSIEM 1913
Query: 216 -IVAREPV-----HTKSSTSSSLNDTTLPETVCWG------HVEEVELINDGSGLGFGIV 263
+VA V H + SSSL+ T L + + + + L GLGF IV
Sbjct: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIV 1973
Query: 264 GGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGN 318
GG S + V+T+ G A DGRL+ GD I+ + G +++G+T E+ +L+
Sbjct: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
Query: 319 SVRMLV 324
+V ++V
Sbjct: 2034 TVTLMV 2039
Score = 89.7 bits (221), Expect = 2e-17
Identities = 114/453 (25%), Positives = 177/453 (39%), Gaps = 144/453 (31%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
+E+ ++P LG+SIVG + G+F+ +++ A L GD+IL V
Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDT----------GVFVSDIVKGGIADADGRLMQGDQILMV 1775
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKK 1188
+G D++NA+ EAV A+ SLSS ++G+ ++ E
Sbjct: 1776 NGEDVRNATQ-EAVAALLKVSEG------SLSSF----------TFPLSGSSTSESLESS 1818
Query: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDK-N 1247
K+ A +++ G L +E++K +
Sbjct: 1819 SKKNALA-----------------------------------SEIQG-LRTVEMKKGPTD 1842
Query: 1248 GLGLSLAGN--KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
LG+S+AG + IF+ ++P G AA ++R+GD ++ I G +H
Sbjct: 1843 SLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQ--- 1899
Query: 1306 IIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIK 1365
AVN + ++ SIE Q + + D SV G +
Sbjct: 1900 ------------------AVNLL--------KNASGSIEMQ-----VVAGGDVSVVTGHQ 1928
Query: 1366 QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDP 1425
Q P S S +SF+ T FQ L
Sbjct: 1929 QEPASSS----------------LSFTG-----------------LTSSSIFQDDLG--- 1952
Query: 1426 ATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN--AIVIHEVYEEGAAARDGRLWAGD 1483
P Q I + +G GLG SIVGG +P I + V+ +GAA+ DGRL GD
Sbjct: 1953 ------PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGD 2006
Query: 1484 QILEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
QI+ VNG L +HEEA+ L++T V L+V
Sbjct: 2007 QIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 81.3 bits (199), Expect = 8e-15
Identities = 77/296 (26%), Positives = 124/296 (41%), Gaps = 60/296 (20%)
Query: 1029 SAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQT 1088
S++T LS +++ E ++ E R VE+ + P SLGISI GG
Sbjct: 1800 SSFTFPLSGSSTSESLESSSKKNALASEIQGL------RTVEMKKGPTDSLGISIAGGV- 1852
Query: 1089 VIKRLKNGEELKG--IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146
G L IFI + A +T L+ GD+I+ + G + +H++AV +K
Sbjct: 1853 -------GSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
Query: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206
NA + V + + +TG+Q + P +
Sbjct: 1906 NASGSIEMQVVA-----------GGDVSVVTGHQQE---------------PASSSLSFT 1939
Query: 1207 ALTDDSDENEEEDAFTDQKIRQRYADL-PGELHIIELEKDKNGLGLSLAGN--KDRSRMS 1263
LT S F D DL P + I LE+ +GLG S+ G +
Sbjct: 1940 GLTSSS-------IFQD--------DLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLP 1984
Query: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319
I+V + +G A+ DGR++ GD+++ +N Q L G +H+ A AI+K V L+ +
Sbjct: 1985 IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 70.1 bits (170), Expect = 2e-11
Identities = 67/251 (26%), Positives = 113/251 (45%), Gaps = 21/251 (8%)
Query: 1530 EIFPVDLQKKAGRGLGLSIVGKRNGS--GVFISDIVKGGAADLDGRLIQGDQILSVNGED 1587
E+ ++L+K GLGLS+ G ++ S VFI I GAA DGRL D++L +NG+
Sbjct: 1347 ELHMIELEK-GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 1588 MRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPV 1647
+ S + ++I+KCA V++ R N Q A + + P+
Sbjct: 1406 LYGRSHQNASSIIKCAPSKVKIIFIR--------------NKDAVNQMAVCPGN-AVEPL 1450
Query: 1648 ITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINREL-SDALGISIAGGRGSPLGDIPVFI 1706
+ +NL + + ++ D+ + EL D G+ IA L V I
Sbjct: 1451 PSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSG--VII 1508
Query: 1707 AMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISA 1766
+ GVAA +LKVGD+I++++ + + G ++LLK A + L + A+ S
Sbjct: 1509 KSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQ 1568
Query: 1767 IAAQLENMSTG 1777
++G
Sbjct: 1569 AVPSAAGAASG 1579
Score = 52.8 bits (125), Expect = 3e-06
Identities = 33/111 (29%), Positives = 58/111 (52%), Gaps = 2/111 (1%)
Query: 1666 KNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGD 1725
KN E+ + S LG S+ G R G++ +F+ IQ VA R +LK D
Sbjct: 127 KNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETD 186
Query: 1726 RIVSINGQPLD-GLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMS 1775
+I++INGQ LD ++H +++L+ A + L V+A ++ + + + + S
Sbjct: 187 QILAINGQALDQTITHQQAISILQKAKDTVQL-VIARGSLPQLVSPIVSRS 236
Score = 45.4 bits (106), Expect = 5e-04
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1064 GPPRIVEIFREPNVS-LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122
GPP+ I E LG SIVGG +G+ I++K V A + LK G
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGS----PHGD--LPIYVKTVFAKGAASEDGRLKRG 2005
Query: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQS 1158
D+I+ V+G L+ +H EAV +K V +V S
Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2041
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 189 bits (479), Expect = 3e-47
Identities = 137/423 (32%), Positives = 211/423 (49%), Gaps = 46/423 (10%)
Query: 1337 SSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEI 1396
S + + IE+++G P + G++ PE++ +++ +S S+E
Sbjct: 153 SRTQAEIENENG--PTLLDPAGTLS------PEADCLGTGAVPVERHLTSASLSTWSEEP 204
Query: 1397 PLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS--GLGLSIVGG 1454
L + S AD T Q PLS+ G+ IEI + LG+SIVGG
Sbjct: 205 GLDNPAFEESAGADTT-----QQPLSLPE-------GEITTIEIHRSNPYIQLGISIVGG 252
Query: 1455 KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRL 1514
+TPL IVI EVY +G ARDGRL AGDQIL+VN ++ N SH A L Q + L
Sbjct: 253 NETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHL 312
Query: 1515 VVYRD-----EAHYRDEENL---EIFPVDLQKK-AGRGLGLSIVGKRNGSGVFISDIVKG 1565
V R+ AH + N EIF V L K+ +G LG+ +V + + GVFI D+++G
Sbjct: 313 TVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEG 372
Query: 1566 GAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTT 1625
G A DGRL D++L++NG D++ + E A I++ + V L I R G T
Sbjct: 373 GLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA--RPGKPQPGNTI 430
Query: 1626 SQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSD 1685
+ S S H + P ++ R S + + + + +E +
Sbjct: 431 REAGNHSSSSQHHTPPPYYS-------------RPSSHKDLTQCVTCQEKHITVKKEPHE 477
Query: 1686 ALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
+LG+++AGGRGS G++P+F+ + G AR ++K GD +++ING L LSH++ V
Sbjct: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
Query: 1746 LLK 1748
+LK
Sbjct: 538 MLK 540
Score = 98.2 bits (243), Expect = 6e-20
Identities = 95/370 (25%), Positives = 159/370 (42%), Gaps = 61/370 (16%)
Query: 1432 PGQEMI-IEISKGRSG--LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEV 1488
P +E+ + + K SG LG+ +V D P + I ++ E G AA+DGRL + D++L +
Sbjct: 333 PREEIFQVALHKRDSGEQLGIKLVRRTDEP--GVFILDLLEGGLAAQDGRLSSNDRVLAI 390
Query: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP----- 1533
NG DL+ + E A ++ + ++V L + R EA + P
Sbjct: 391 NGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYS 450
Query: 1534 ------------------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLD 1571
+ ++K+ LG+++ G R +F++ + G D
Sbjct: 451 RPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARD 510
Query: 1572 GRLIQGDQILSVNGEDMRNASQETVATILKC--AQGLVQLEIGRLRAGSWTSARTTSQNS 1629
GR+ +GD +L++NG D+ N S +LK A V L+ ++ + Q S
Sbjct: 511 GRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPS 570
Query: 1630 QGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
S+ +S PS+ + GL PS +S D + + R + G
Sbjct: 571 TFSENEYDASWSPSWVMWL-GL-----------PSTLHSCHD-----IVLRRSYLGSWGF 613
Query: 1690 SIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
SI GG + P FI I A +LK GD IV++NG G+SH+ +V +LK
Sbjct: 614 SIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKE 673
Query: 1750 AYGRIILQVV 1759
++ L V+
Sbjct: 674 QRNKVTLTVI 683
Score = 94.4 bits (233), Expect = 9e-19
Identities = 83/307 (27%), Positives = 146/307 (47%), Gaps = 23/307 (7%)
Query: 145 LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIA 204
LG S+V L ++I +++V V RD RL DQIL +N+ + N+SH A A
Sbjct: 245 LGISIVGGNETPL--INIVIQEVYRDGVIARDGRLLAGDQILQVNNYNIS-NVSHNYARA 301
Query: 205 LLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVG 264
+L Q +L L V RE + + + +D+ P + +V L SG GI
Sbjct: 302 VLSQPCNTLHLTVLRE--RRFGNRAHNHSDSNSPRE----EIFQVALHKRDSGEQLGIKL 355
Query: 265 GKTS---GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVR 321
+ + GV + ++ GGLA +DGRL + D +L I G +++ T E AQ+++ G V
Sbjct: 356 VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVN 415
Query: 322 MLVAR----DPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY-----NVELVRKD 372
+ +AR P I ++ P P S L + ++ + ++
Sbjct: 416 LTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEP 475
Query: 373 GQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
+SLG+ + G G S +GE I+V S+ P +G I+ D ++ ++G+++ ++
Sbjct: 476 HESLGMTVAGGRG-SKSGELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
Query: 433 DVVEVLR 439
+ V +L+
Sbjct: 534 EAVAMLK 540
Score = 88.6 bits (218), Expect = 5e-17
Identities = 110/480 (22%), Positives = 182/480 (37%), Gaps = 94/480 (19%)
Query: 1217 EEDAFTDQKIRQRYADLP-GELHIIELEKDKN--GLGLSLAGNKDRSRMSIFVVGINPEG 1273
EE A D Q+ LP GE+ IE+ + LG+S+ G + ++I + + +G
Sbjct: 212 EESAGADTT--QQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDG 269
Query: 1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPF 1333
A DGR+ GD++L++NN + SH A A++ + + L +R N+
Sbjct: 270 VIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNR------ 323
Query: 1334 PVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQ----------- 1382
+ S S+ + + + D ++GIK + ++ + + + +
Sbjct: 324 -AHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLS 382
Query: 1383 ------------QKYPTK------VSFSSQEIPLA--------------PASSYHSTDAD 1410
KY T + S + + L A ++ S+
Sbjct: 383 SNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQH 442
Query: 1411 FTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN--AIVIHEVY 1468
T + P S T + ++ I + LG+++ GG+ + I + V
Sbjct: 443 HTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVP 502
Query: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ------KVRLVVYRDEAH 1522
G ARDGR+ GD +L +NG+DL N SH EA+ L+ + K V +EA
Sbjct: 503 PHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEAT 562
Query: 1523 YRDEENLEIF---------------------------PVDLQKKAGRGLGLSIVG----K 1551
EE F + L++ G SIVG
Sbjct: 563 QNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEEN 622
Query: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
FI IV G A DGRL GD I++VNG S + +LK + V L +
Sbjct: 623 HTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
Score = 84.7 bits (208), Expect = 7e-16
Identities = 85/328 (25%), Positives = 151/328 (46%), Gaps = 47/328 (14%)
Query: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR-- 219
+F+ D+ G +A +D RL ND++LAIN L + + A ++Q + + L +AR
Sbjct: 364 VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYG-TPELAAQIIQASGERVNLTIARPG 422
Query: 220 --EPVHT------KSSTS------------SSLNDTTLPETVCWGHVEEVELINDGSGLG 259
+P +T SS+S SS D T T H+ + ++ LG
Sbjct: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHES--LG 480
Query: 260 FGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
+ GG+ S + V ++ P G RDGR++ GD +L I G ++ ++ + +L+
Sbjct: 481 MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
Query: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTV------ASKGP------GSDSSLFE 362
S + + A ++ + A T AS P G S+L
Sbjct: 541 ASAASPAVALK---ALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHS 597
Query: 363 TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
+++ L R S G IVG +HT + ++K+I+ G+ AY++G ++ D IVAV+
Sbjct: 598 CHDIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVN 655
Query: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLV 450
G++ G ++ +V +L+ V LT++
Sbjct: 656 GLSTVGMSHSALVPMLKEQRNKVTLTVI 683
Score = 74.3 bits (181), Expect = 1e-12
Identities = 72/272 (26%), Positives = 111/272 (40%), Gaps = 28/272 (10%)
Query: 79 RKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIE 138
R L + G GN R + N + S P + + Q ++I ++
Sbjct: 413 RVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVK 472
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
+ LG +V R G++ IFV V P RD R+K D +L IN L N+S
Sbjct: 473 KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDL-TNLS 531
Query: 199 HQQAIALLQQTTGS-------LRLIVAREPVHTKSSTSSSLNDTTL-----PETVCW-GH 245
H +A+A+L+ + S L + + E S+ ++ P V W G
Sbjct: 532 HSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGL 591
Query: 246 VEEVELIND--------GSGLGFGIVGG-----KTSGVVVRTIVPGGLADRDGRLQTGDH 292
+ +D GS GF IVGG ++TIV G A DGRL+ GD
Sbjct: 592 PSTLHSCHDIVLRRSYLGS-WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
Query: 293 ILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV 324
I+ + G + GM+ + +L+ N V + V
Sbjct: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
Score = 73.6 bits (179), Expect = 2e-12
Identities = 76/266 (28%), Positives = 111/266 (41%), Gaps = 43/266 (16%)
Query: 1049 REEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
RE G N S PR EIF+ V+L G Q IK ++ +E G+FI +L
Sbjct: 316 RERRFGNRAHNHSDSNSPR-EEIFQ---VALHKRDSGEQLGIKLVRRTDE-PGVFILDLL 370
Query: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
E A + L + D++L ++G DL+ + A + I+ +G V + P
Sbjct: 371 EGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR--------PG 422
Query: 1169 VHNKANKI--TGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKI 1226
N I GN + +Q T PP P +K LT T Q
Sbjct: 423 KPQPGNTIREAGNHSSSSQHH------TPPPYYSRPSSHKDLTQ---------CVTCQ-- 465
Query: 1227 RQRYADLPGELHIIELEKDKNGLGLSLAGNKDRS--RMSIFVVGINPEGPAAADGRMRIG 1284
E HI ++ LG+++AG + + IFV + P G A DGR++ G
Sbjct: 466 ---------EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRG 516
Query: 1285 DELLEINNQILYGRSHQNASAIIKTA 1310
D LL IN L SH A A++K +
Sbjct: 517 DVLLNINGIDLTNLSHSEAVAMLKAS 542
Score = 73.2 bits (178), Expect = 2e-12
Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 28/229 (12%)
Query: 229 SSSLNDTTLPETVCWGHVEEVEL--INDGSGLGFGIVGGKTS---GVVVRTIVPGGLADR 283
S+ + T P ++ G + +E+ N LG IVGG + +V++ + G+ R
Sbjct: 214 SAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIAR 273
Query: 284 DGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343
DGRL GD IL++ N+ ++ VL N++ + V R+
Sbjct: 274 DGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR-------------- 319
Query: 344 VALPTVASKGPGSDSSLFETYNVELVRKD-GQSLGIRIVGYVGTSHTGEASGIYVKSIIP 402
A S+S E + V L ++D G+ LGI++V + G+++ ++
Sbjct: 320 --FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLV------RRTDEPGVFILDLLE 371
Query: 403 GSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
G A +G + ND+++A++G +++ ++++ +G+ V+LT+ R
Sbjct: 372 GGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
Score = 66.2 bits (160), Expect = 3e-10
Identities = 64/258 (24%), Positives = 107/258 (41%), Gaps = 50/258 (19%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
+ + +EP+ SLG+++ GG + K+GE IF+ V + +K GD +L +
Sbjct: 469 ITVKKEPHESLGMTVAGG----RGSKSGE--LPIFVTSVPPHGCLARDGRIKRGDVLLNI 522
Query: 1129 SGVDLQNASHSEAVEAIK-NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEK 1187
+G+DL N SHSEAV +K +A +P V + + + Q
Sbjct: 523 NGIDLTNLSHSEAVAMLKASAASPAVAL------------------------KALEVQIV 558
Query: 1188 KEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELH----IIELE 1243
+E Q P ENE + +++ + + LP LH I+
Sbjct: 559 EEATQNAEEQPSTF-----------SENEYDASWSPSWVM--WLGLPSTLHSCHDIVLRR 605
Query: 1244 KDKNGLGLSLAGN--KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301
G S+ G ++ + F+ I PA DGR++ GD ++ +N G SH
Sbjct: 606 SYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHS 665
Query: 1302 NASAIIKTAPSKVKLVFI 1319
++K +KV L I
Sbjct: 666 ALVPMLKEQRNKVTLTVI 683
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 6/93 (6%)
Query: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPL 773
IVI+ + DGV R G LL GD+++ VN Y + N S A +L + P +HL + +
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL-SQPCNTLHLTVLRER 318
Query: 774 VEDNEEESCYILHSSSNEDKTE-FSGTIHDINS 805
N + HS SN + E F +H +S
Sbjct: 319 RFGNRAHN----HSDSNSPREEIFQVALHKRDS 347
Score = 36.2 bits (82), Expect = 0.30
Identities = 51/208 (24%), Positives = 81/208 (38%), Gaps = 35/208 (16%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK--EVPPPFTLVCCRRL 639
+++S+ G + G ++ D LL +NG+ L S EAV+ LK P L
Sbjct: 497 FVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQ 556
Query: 640 FDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCKG 695
+EA+ + + T E E D A WSP + + + C
Sbjct: 557 IVEEATQNAEEQPST-FSENEYD---------------ASWSPSWVMWLGLPSTLHSCHD 600
Query: 696 L----------GFSIL-DYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744
+ GFSI+ Y++ + T I+++V A G L GD +V+VN
Sbjct: 601 IVLRRSYLGSWGFSIVGGYEE--NHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLS 658
Query: 745 LDNTSLAEAVEILKAVPPGLVHLGICKP 772
S + V +LK + IC P
Sbjct: 659 TVGMSHSALVPMLKEQRNKVTLTVICWP 686
Score = 32.3 bits (72), Expect = 4.3
Identities = 40/168 (23%), Positives = 63/168 (37%), Gaps = 33/168 (19%)
Query: 327 DPAGDISVTP--------PAPAALPVALPTVASKGPGSDSSLFE------TYNVELVRKD 372
DPAG +S P L A + S+ PG D+ FE T L +
Sbjct: 169 DPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPE 228
Query: 373 GQSLGIRI----------VGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
G+ I I + VG + T I ++ + +G + D+I+ V+
Sbjct: 229 GEITTIEIHRSNPYIQLGISIVGGNET-PLINIVIQEVYRDGVIARDGRLLAGDQILQVN 287
Query: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKT--------SSSTSPLE 462
NI +++ VL +HLT++R + S S SP E
Sbjct: 288 NYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPRE 335
Score = 31.6 bits (70), Expect = 7.3
Identities = 18/46 (39%), Positives = 26/46 (56%)
Query: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
I + S+ G R G + GD L+++N L N S +EAV +LKA
Sbjct: 496 IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKA 541
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 154 bits (389), Expect = 7e-37
Identities = 126/455 (27%), Positives = 218/455 (47%), Gaps = 45/455 (9%)
Query: 1329 AVTPFPVPSSSP--SSIEDQSGTEP---ISSEEDGS-----VEVGIKQLPESESFKLAVS 1378
A P P S++ S + D+ G + +SS EDG V+ G + F+ +
Sbjct: 157 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 216
Query: 1379 QMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI- 1437
+ + K + + A + H+ D AP V P ++P E+
Sbjct: 217 RSRSFKKINRALSVLRRTKSGSAVANHA-DQGRENSENTTAP-EVFPRLYHLIPDGEITS 274
Query: 1438 IEISK--GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
I+I++ L + +VGG +TPL I+I +Y +G ARDGRL GD IL+VNG+D+ N
Sbjct: 275 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334
Query: 1496 SSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEI----------FPVDLQKKA-GRGL 1544
H A+ LRQ Q + L V R E +R N + F V L K + L
Sbjct: 335 VPHNYAVRLLRQPCQVLWLTVMR-EQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQL 393
Query: 1545 GLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQ 1604
G+ +V K + GVFI +++ GG A G+L + D++L++NG D+R S E+ A +++ ++
Sbjct: 394 GIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 453
Query: 1605 GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPS 1664
V L + +R Q S Q A + + S++P +R + P
Sbjct: 454 RRVHLVV----------SRQVRQRSPDIFQEAGWNSNGSWSP--------GPGERSNTPK 495
Query: 1665 QKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
+ + V I ++ ++LG+++AGG D+P+++ ++ GV +R ++K G
Sbjct: 496 PLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTG 555
Query: 1725 DRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
D +++++G L +S ++ V LLK I+L+ +
Sbjct: 556 DILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 590
Score = 95.1 bits (235), Expect = 5e-19
Identities = 91/360 (25%), Positives = 151/360 (41%), Gaps = 54/360 (15%)
Query: 1436 MIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
+I+ S LG+ +V D P + I V + G A R G+L D++L +NG DLR
Sbjct: 382 VILNKSSPEEQLGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 439
Query: 1496 SSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP------------ 1533
S E A ++ + ++V LVV R EA + + P
Sbjct: 440 GSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP 499
Query: 1534 --------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQIL 1581
V++QK G LG+++ G + +++ + GG DGR+ GD +L
Sbjct: 500 TITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILL 559
Query: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCH 1641
+V+G ++ S+ +LK + L+ L + S S + S H+
Sbjct: 560 NVDGVELTEVSRSEAVALLKRTSSSIVLKA--LEVKEYEPQEDCS--SPAALDSNHNMAP 615
Query: 1642 PS-FAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLG 1700
PS ++P L P + D + + R + +LG I GG G
Sbjct: 616 PSDWSPSWVMWLEL--------PRCLYNCKD-----IVLRRNTAGSLGFCIVGGYEEYNG 662
Query: 1701 DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
+ P FI I A +++ GD ++++NG+ G+ HA + LLK GRI L +V+
Sbjct: 663 NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 722
Score = 95.1 bits (235), Expect = 5e-19
Identities = 90/335 (26%), Positives = 152/335 (45%), Gaps = 56/335 (16%)
Query: 159 KVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215
KVD +F+ +V G VA R +L+END++LAIN L S + A L+Q + + L
Sbjct: 400 KVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHL 458
Query: 216 IVAREPVHT----------------------KSSTSSSLNDTTLPETVCWGHVEEVELIN 253
+V+R+ +S+T L+ P C H + V +
Sbjct: 459 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLH----PTITC--HEKVVNIQK 512
Query: 254 D-GSGLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSE 307
D G LG + GG + + V ++ PGG+ RDGR++TGD +L + G + ++
Sbjct: 513 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 572
Query: 308 QVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS-------- 359
+ +L+ +S+ +L A + P + P AL + + P SD S
Sbjct: 573 EAVALLKRTSSSI-VLKALEVK---EYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLE 628
Query: 360 ----LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
L+ ++ L R SLG IVG G ++KSI+ G+ AY++G I+
Sbjct: 629 LPRCLYNCKDIVLRRNTAGSLGFCIVG--GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
Query: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
D ++AV+G + G + + +L+ + LT+V
Sbjct: 687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721
Score = 80.1 bits (196), Expect = 2e-14
Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 43/335 (12%)
Query: 160 VDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
V I ++ + V RD RL D IL +N + N+ H A+ LL+Q L L V R
Sbjct: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS-NVPHNYAVRLLRQPCQVLWLTVMR 357
Query: 220 EPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSG---LGFGIVGGKTS-GVVVRTI 275
E +S + D P + HV ++N S LG +V GV + +
Sbjct: 358 EQKF-RSRNNGQAPDAYRPRDDSF-HV----ILNKSSPEEQLGIKLVRKVDEPGVFIFNV 411
Query: 276 VPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVT 335
+ GG+A R G+L+ D +L I G +++ + E A +++ V ++V+R V
Sbjct: 412 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ------VR 465
Query: 336 PPAPAALPVA---LPTVASKGPGSDSSLFETYN---------VELVRKDGQSLGIRIVGY 383
+P A S GPG S+ + + V + + G+SLG+ + G
Sbjct: 466 QRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG- 524
Query: 384 VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443
G SH IYV S+ PG +G I+ D ++ VDGV + + + V +L+
Sbjct: 525 -GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSS 583
Query: 444 VVHLTLVRRK------------TSSSTSPLEPPSD 466
+ L + K S + PPSD
Sbjct: 584 SIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618
Score = 70.5 bits (171), Expect = 1e-11
Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 25/218 (11%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
++I++ LG +V S + I+V V+PG V RD R+K D +L ++ L
Sbjct: 508 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 567
Query: 195 QNISHQQAIALLQQTTGSLRL----IVAREPVHTKSSTSSSLNDTTL-------PETVCW 243
+ +S +A+ALL++T+ S+ L + EP SS ++ ++ + P V W
Sbjct: 568 E-VSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
Query: 244 GHVEE--------VELINDGSGLGFGIVGGK-----TSGVVVRTIVPGGLADRDGRLQTG 290
+ V N LGF IVGG +++IV G A DGR++ G
Sbjct: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
Query: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
D +L + G + GM +A++L+ + + + P
Sbjct: 687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 724
Score = 64.3 bits (155), Expect = 1e-09
Identities = 55/247 (22%), Positives = 111/247 (44%), Gaps = 41/247 (16%)
Query: 248 EVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
++ ++ L +VGG + ++++ I G+ RDGRL GD ILK+ G ++ +
Sbjct: 276 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 335
Query: 305 TSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY 364
++LR + + V R+ AP A P DS +
Sbjct: 336 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR----------PRDDS-----F 380
Query: 365 NVELVRKDGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDG 423
+V L + + LGI++V V + G+++ +++ G AY +G ++ ND+++A++G
Sbjct: 381 HVILNKSSPEEQLGIKLVRKV------DEPGVFIFNVLDGGVAYRHGQLEENDRVLAING 434
Query: 424 VNIQGFANHDVVEVLRNAGQVVHLTLVRR--------------KTSSSTSPLEPPSDRGT 469
+++ + +++ + + VHL + R+ ++ S SP P +R
Sbjct: 435 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP--GPGERSN 492
Query: 470 VVEPLKP 476
+PL P
Sbjct: 493 TPKPLHP 499
Score = 58.2 bits (139), Expect = 7e-08
Identities = 65/285 (22%), Positives = 104/285 (36%), Gaps = 68/285 (23%)
Query: 1052 GEGEETPNFSH---WGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
GE TP H ++V I ++P SLG+++ GG + + E I++ V
Sbjct: 488 GERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGAS------HREWDLPIYVISVE 541
Query: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--------FIVQSLS 1160
+ +KTGD +L V GV+L S SEAV +K + +V + Q
Sbjct: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
Query: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDA 1220
S+P + + HN A PP P +
Sbjct: 602 SSPAALDSNHNMA-----------------------PPSDWSPSW--------------- 623
Query: 1221 FTDQKIRQRYADLPGELH----IIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGP 1274
+ +LP L+ I+ LG + G + F+ I P
Sbjct: 624 -------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 676
Query: 1275 AAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319
A DGR+R GD LL +N + G H + ++K ++ L +
Sbjct: 677 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721
Score = 51.6 bits (122), Expect = 7e-06
Identities = 59/270 (21%), Positives = 108/270 (40%), Gaps = 47/270 (17%)
Query: 1087 QTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146
Q IK ++ +E G+FI VL+ A + L+ D++L ++G DL+ S A I+
Sbjct: 392 QLGIKLVRKVDE-PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 450
Query: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206
+ V +V + P++ +A N N +R T P P+
Sbjct: 451 ASERRVHLVVSR--QVRQRSPDIFQEAG---WNSNGSWSPGPGERSNT-PKPL------- 497
Query: 1207 ALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSR--MS 1263
+ + ++ ++KD LG+++AG +
Sbjct: 498 -----------------------HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLP 534
Query: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED 1323
I+V+ + P G + DGR++ GD LL ++ L S A A++K S + L + ++
Sbjct: 535 IYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 594
Query: 1324 AVNQMAVTPFPVPSSSPSSIEDQSGTEPIS 1353
Q SSP++++ P S
Sbjct: 595 YEPQ-------EDCSSPAALDSNHNMAPPS 617
Score = 44.7 bits (104), Expect = 8e-04
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 30/174 (17%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Y+ S+ GG + G ++ D LL V+G++L SR EAV+ LK L
Sbjct: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL----- 590
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCK--- 694
E EP+ +S + +HNM ++ WSP +++ + +CK
Sbjct: 591 -EVKEYEPQEDCSSPAALDSNHNMAPPSD---------WSPSWVMWLELPRCLYNCKDIV 640
Query: 695 -------GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
LGF I+ + + + I+S+V A G + GD L++VN
Sbjct: 641 LRRNTAGSLGFCIVGGYEEYNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVN 693
Score = 41.6 bits (96), Expect = 0.007
Identities = 52/248 (20%), Positives = 88/248 (35%), Gaps = 67/248 (27%)
Query: 1074 EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDL 1133
+P+ SL I +VGG L I I+ + D + L GD IL+V+G+D+
Sbjct: 281 DPSESLSIRLVGGSET--------PLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 332
Query: 1134 QNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQG 1193
N H+ AV ++ + V Q+ + + G
Sbjct: 333 SNVPHNYAVRLLRQPCQVLWLTVMR-------------------------EQKFRSRNNG 367
Query: 1194 TAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHII-ELEKDKNGLGLS 1252
AP + +D+F H+I + LG+
Sbjct: 368 QAPDAYR---------------PRDDSF----------------HVILNKSSPEEQLGIK 396
Query: 1253 LAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
L D +F+ + G A G++ D +L IN L S ++A+ +I+ +
Sbjct: 397 LVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER 454
Query: 1313 KVKLVFIR 1320
+V LV R
Sbjct: 455 RVHLVVSR 462
Score = 35.8 bits (81), Expect = 0.39
Identities = 18/45 (40%), Positives = 26/45 (57%)
Query: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
I+I+ + DGV R G LLPGD ++ VN + N AV +L+
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
Score = 35.4 bits (80), Expect = 0.50
Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 6/85 (7%)
Query: 1078 SLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
SLG IVGG NG K FIK ++E +PA ++ GD +L V+G
Sbjct: 648 SLGFCIVGGYEEY----NGN--KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 701
Query: 1138 HSEAVEAIKNAGNPVVFIVQSLSST 1162
H+ +K + + S T
Sbjct: 702 HACLARLLKELKGRITLTIVSWPGT 726
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 154 bits (389), Expect = 7e-37
Identities = 126/455 (27%), Positives = 218/455 (47%), Gaps = 45/455 (9%)
Query: 1329 AVTPFPVPSSSP--SSIEDQSGTEP---ISSEEDGS-----VEVGIKQLPESESFKLAVS 1378
A P P S++ S + D+ G + +SS EDG V+ G + F+ +
Sbjct: 61 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 120
Query: 1379 QMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI- 1437
+ + K + + A + H+ D AP V P ++P E+
Sbjct: 121 RSRSFKKINRALSVLRRTKSGSAVANHA-DQGRENSENTTAP-EVFPRLYHLIPDGEITS 178
Query: 1438 IEISK--GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
I+I++ L + +VGG +TPL I+I +Y +G ARDGRL GD IL+VNG+D+ N
Sbjct: 179 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 238
Query: 1496 SSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEI----------FPVDLQKKA-GRGL 1544
H A+ LRQ Q + L V R E +R N + F V L K + L
Sbjct: 239 VPHNYAVRLLRQPCQVLWLTVMR-EQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQL 297
Query: 1545 GLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQ 1604
G+ +V K + GVFI +++ GG A G+L + D++L++NG D+R S E+ A +++ ++
Sbjct: 298 GIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 357
Query: 1605 GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPS 1664
V L + +R Q S Q A + + S++P +R + P
Sbjct: 358 RRVHLVV----------SRQVRQRSPDIFQEAGWNSNGSWSP--------GPGERSNTPK 399
Query: 1665 QKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
+ + V I ++ ++LG+++AGG D+P+++ ++ GV +R ++K G
Sbjct: 400 PLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTG 459
Query: 1725 DRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
D +++++G L +S ++ V LLK I+L+ +
Sbjct: 460 DILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 494
Score = 95.1 bits (235), Expect = 5e-19
Identities = 91/360 (25%), Positives = 151/360 (41%), Gaps = 54/360 (15%)
Query: 1436 MIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
+I+ S LG+ +V D P + I V + G A R G+L D++L +NG DLR
Sbjct: 286 VILNKSSPEEQLGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 343
Query: 1496 SSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP------------ 1533
S E A ++ + ++V LVV R EA + + P
Sbjct: 344 GSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP 403
Query: 1534 --------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQIL 1581
V++QK G LG+++ G + +++ + GG DGR+ GD +L
Sbjct: 404 TITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILL 463
Query: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCH 1641
+V+G ++ S+ +LK + L+ L + S S + S H+
Sbjct: 464 NVDGVELTEVSRSEAVALLKRTSSSIVLKA--LEVKEYEPQEDCS--SPAALDSNHNMAP 519
Query: 1642 PS-FAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLG 1700
PS ++P L P + D + + R + +LG I GG G
Sbjct: 520 PSDWSPSWVMWLEL--------PRCLYNCKD-----IVLRRNTAGSLGFCIVGGYEEYNG 566
Query: 1701 DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
+ P FI I A +++ GD ++++NG+ G+ HA + LLK GRI L +V+
Sbjct: 567 NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 626
Score = 95.1 bits (235), Expect = 5e-19
Identities = 90/335 (26%), Positives = 152/335 (45%), Gaps = 56/335 (16%)
Query: 159 KVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215
KVD +F+ +V G VA R +L+END++LAIN L S + A L+Q + + L
Sbjct: 304 KVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHL 362
Query: 216 IVAREPVHT----------------------KSSTSSSLNDTTLPETVCWGHVEEVELIN 253
+V+R+ +S+T L+ P C H + V +
Sbjct: 363 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLH----PTITC--HEKVVNIQK 416
Query: 254 D-GSGLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSE 307
D G LG + GG + + V ++ PGG+ RDGR++TGD +L + G + ++
Sbjct: 417 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 476
Query: 308 QVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS-------- 359
+ +L+ +S+ +L A + P + P AL + + P SD S
Sbjct: 477 EAVALLKRTSSSI-VLKALEVK---EYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLE 532
Query: 360 ----LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
L+ ++ L R SLG IVG G ++KSI+ G+ AY++G I+
Sbjct: 533 LPRCLYNCKDIVLRRNTAGSLGFCIVG--GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
Query: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
D ++AV+G + G + + +L+ + LT+V
Sbjct: 591 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625
Score = 80.1 bits (196), Expect = 2e-14
Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 43/335 (12%)
Query: 160 VDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
V I ++ + V RD RL D IL +N + N+ H A+ LL+Q L L V R
Sbjct: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS-NVPHNYAVRLLRQPCQVLWLTVMR 261
Query: 220 EPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSG---LGFGIVGGKTS-GVVVRTI 275
E +S + D P + HV ++N S LG +V GV + +
Sbjct: 262 EQKF-RSRNNGQAPDAYRPRDDSF-HV----ILNKSSPEEQLGIKLVRKVDEPGVFIFNV 315
Query: 276 VPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVT 335
+ GG+A R G+L+ D +L I G +++ + E A +++ V ++V+R V
Sbjct: 316 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ------VR 369
Query: 336 PPAPAALPVA---LPTVASKGPGSDSSLFETYN---------VELVRKDGQSLGIRIVGY 383
+P A S GPG S+ + + V + + G+SLG+ + G
Sbjct: 370 QRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG- 428
Query: 384 VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443
G SH IYV S+ PG +G I+ D ++ VDGV + + + V +L+
Sbjct: 429 -GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSS 487
Query: 444 VVHLTLVRRK------------TSSSTSPLEPPSD 466
+ L + K S + PPSD
Sbjct: 488 SIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522
Score = 70.5 bits (171), Expect = 1e-11
Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 25/218 (11%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
++I++ LG +V S + I+V V+PG V RD R+K D +L ++ L
Sbjct: 412 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 471
Query: 195 QNISHQQAIALLQQTTGSLRL----IVAREPVHTKSSTSSSLNDTTL-------PETVCW 243
+ +S +A+ALL++T+ S+ L + EP SS ++ ++ + P V W
Sbjct: 472 E-VSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
Query: 244 GHVEE--------VELINDGSGLGFGIVGGK-----TSGVVVRTIVPGGLADRDGRLQTG 290
+ V N LGF IVGG +++IV G A DGR++ G
Sbjct: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
Query: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
D +L + G + GM +A++L+ + + + P
Sbjct: 591 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 628
Score = 64.3 bits (155), Expect = 1e-09
Identities = 55/247 (22%), Positives = 111/247 (44%), Gaps = 41/247 (16%)
Query: 248 EVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
++ ++ L +VGG + ++++ I G+ RDGRL GD ILK+ G ++ +
Sbjct: 180 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 239
Query: 305 TSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY 364
++LR + + V R+ AP A P DS +
Sbjct: 240 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR----------PRDDS-----F 284
Query: 365 NVELVRKDGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDG 423
+V L + + LGI++V V + G+++ +++ G AY +G ++ ND+++A++G
Sbjct: 285 HVILNKSSPEEQLGIKLVRKV------DEPGVFIFNVLDGGVAYRHGQLEENDRVLAING 338
Query: 424 VNIQGFANHDVVEVLRNAGQVVHLTLVRR--------------KTSSSTSPLEPPSDRGT 469
+++ + +++ + + VHL + R+ ++ S SP P +R
Sbjct: 339 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP--GPGERSN 396
Query: 470 VVEPLKP 476
+PL P
Sbjct: 397 TPKPLHP 403
Score = 58.2 bits (139), Expect = 7e-08
Identities = 65/285 (22%), Positives = 104/285 (36%), Gaps = 68/285 (23%)
Query: 1052 GEGEETPNFSH---WGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
GE TP H ++V I ++P SLG+++ GG + + E I++ V
Sbjct: 392 GERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGAS------HREWDLPIYVISVE 445
Query: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--------FIVQSLS 1160
+ +KTGD +L V GV+L S SEAV +K + +V + Q
Sbjct: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
Query: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDA 1220
S+P + + HN A PP P +
Sbjct: 506 SSPAALDSNHNMA-----------------------PPSDWSPSW--------------- 527
Query: 1221 FTDQKIRQRYADLPGELH----IIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGP 1274
+ +LP L+ I+ LG + G + F+ I P
Sbjct: 528 -------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 580
Query: 1275 AAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319
A DGR+R GD LL +N + G H + ++K ++ L +
Sbjct: 581 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625
Score = 51.6 bits (122), Expect = 7e-06
Identities = 59/270 (21%), Positives = 108/270 (40%), Gaps = 47/270 (17%)
Query: 1087 QTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146
Q IK ++ +E G+FI VL+ A + L+ D++L ++G DL+ S A I+
Sbjct: 296 QLGIKLVRKVDE-PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 354
Query: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206
+ V +V + P++ +A N N +R T P P+
Sbjct: 355 ASERRVHLVVSR--QVRQRSPDIFQEAG---WNSNGSWSPGPGERSNT-PKPL------- 401
Query: 1207 ALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSR--MS 1263
+ + ++ ++KD LG+++AG +
Sbjct: 402 -----------------------HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLP 438
Query: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED 1323
I+V+ + P G + DGR++ GD LL ++ L S A A++K S + L + ++
Sbjct: 439 IYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 498
Query: 1324 AVNQMAVTPFPVPSSSPSSIEDQSGTEPIS 1353
Q SSP++++ P S
Sbjct: 499 YEPQ-------EDCSSPAALDSNHNMAPPS 521
Score = 44.7 bits (104), Expect = 8e-04
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 30/174 (17%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Y+ S+ GG + G ++ D LL V+G++L SR EAV+ LK L
Sbjct: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL----- 494
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCK--- 694
E EP+ +S + +HNM ++ WSP +++ + +CK
Sbjct: 495 -EVKEYEPQEDCSSPAALDSNHNMAPPSD---------WSPSWVMWLELPRCLYNCKDIV 544
Query: 695 -------GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
LGF I+ + + + I+S+V A G + GD L++VN
Sbjct: 545 LRRNTAGSLGFCIVGGYEEYNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVN 597
Score = 41.6 bits (96), Expect = 0.007
Identities = 52/248 (20%), Positives = 88/248 (35%), Gaps = 67/248 (27%)
Query: 1074 EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDL 1133
+P+ SL I +VGG L I I+ + D + L GD IL+V+G+D+
Sbjct: 185 DPSESLSIRLVGGSET--------PLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 236
Query: 1134 QNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQG 1193
N H+ AV ++ + V Q+ + + G
Sbjct: 237 SNVPHNYAVRLLRQPCQVLWLTVMR-------------------------EQKFRSRNNG 271
Query: 1194 TAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHII-ELEKDKNGLGLS 1252
AP + +D+F H+I + LG+
Sbjct: 272 QAPDAYR---------------PRDDSF----------------HVILNKSSPEEQLGIK 300
Query: 1253 LAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
L D +F+ + G A G++ D +L IN L S ++A+ +I+ +
Sbjct: 301 LVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER 358
Query: 1313 KVKLVFIR 1320
+V LV R
Sbjct: 359 RVHLVVSR 366
Score = 35.8 bits (81), Expect = 0.39
Identities = 18/45 (40%), Positives = 26/45 (57%)
Query: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
I+I+ + DGV R G LLPGD ++ VN + N AV +L+
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
Score = 35.4 bits (80), Expect = 0.50
Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 6/85 (7%)
Query: 1078 SLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
SLG IVGG NG K FIK ++E +PA ++ GD +L V+G
Sbjct: 552 SLGFCIVGGYEEY----NGN--KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 605
Query: 1138 HSEAVEAIKNAGNPVVFIVQSLSST 1162
H+ +K + + S T
Sbjct: 606 HACLARLLKELKGRITLTIVSWPGT 630
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 149 bits (376), Expect = 2e-35
Identities = 156/545 (28%), Positives = 229/545 (42%), Gaps = 126/545 (23%)
Query: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
LGISI GG+ + E GIFI +V E+ PA + ++ GDK+LEV+GV LQ A H
Sbjct: 738 LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
EAVEA++ AG VQ R++ A IT + +D +E+R G P
Sbjct: 794 HEAVEALRGAGT----AVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGLRLP 847
Query: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
+ LPP + +RQR H+ L + + GLG S+AG K
Sbjct: 848 L-LPPE-----------------SPGPLRQR--------HVACLARSERGLGFSIAGGKG 881
Query: 1259 RS-----RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
+ IFV I G A G +++GD +L IN + H +A +++ A
Sbjct: 882 STPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Query: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
+ L+ R + P P+P SSP T +++ + G+ LP
Sbjct: 942 IALLLEREAGG----PLPPSPLPHSSPP-------TAAVATTSITTATPGVPGLPSLAPS 990
Query: 1374 KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPG 1433
LA + + P V+ P G
Sbjct: 991 LLAAA--------------------------------------LEGPYPVEEIRLPRAGG 1012
Query: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN-------AIVIHEVYEEGAAARDGRLWAGDQIL 1486
LGLSIVGG D + + I +V G AAR G L GD+IL
Sbjct: 1013 P------------LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRIL 1059
Query: 1487 EVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
VNG D+R+++H+EA++AL + ++ L+V RD A E + +QK G LG+
Sbjct: 1060 AVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE------LCIQKAPGERLGI 1113
Query: 1547 SIVGKRNG----------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
SI G G G+FIS + GAA DGRL G ++L VN + + +
Sbjct: 1114 SIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEA 1173
Query: 1597 ATILK 1601
+L+
Sbjct: 1174 VQLLR 1178
Score = 122 bits (306), Expect = 3e-27
Identities = 120/379 (31%), Positives = 177/379 (46%), Gaps = 67/379 (17%)
Query: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGK-DTPLNA----IVIHEVYEEGAAAR 1475
L ++PA + +E+ + I + GLG+SI GGK TP I I V EEG AAR
Sbjct: 715 LLIEPAR---IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
Query: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD---------------- 1519
G + GD++LEVNGV L+ + H EA+ ALR V++ V+R+
Sbjct: 772 AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
Query: 1520 EAHYRDEEN------LEIFP-----------VDLQKKAGRGLGLSIVGKRNGS------- 1555
E Y E L + P V ++ RGLG SI G + +
Sbjct: 831 EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDA 890
Query: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR 1615
G+F+S I +GGAA G L GD++LS+NG D+ A + ++L A + L + R
Sbjct: 891 GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER-E 949
Query: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675
AG +S + A +S + P + GL +L PS + + P
Sbjct: 950 AGGPLPPSPLPHSSPPTAAVATTSI-TTATPGVPGLPSLA-------PSLLAAALE-GPY 1000
Query: 1676 TVEINR--ELSDALGISIAGG---RGSPLG--DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
VE R LG+SI GG P G + VFI+ + G+AAR+ L+VGDRI+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRIL 1059
Query: 1729 SINGQPLDGLSHADVVNLL 1747
++NGQ + +H + V+ L
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 93.2 bits (230), Expect = 2e-18
Identities = 109/423 (25%), Positives = 174/423 (41%), Gaps = 98/423 (23%)
Query: 98 PSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERP-------------STGG 144
P N T++ L P ED S ++ G ++ + E P S G
Sbjct: 819 PENAVTITPLRP-------EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG 871
Query: 145 LGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
LGFS+ + G IFV + G A R L+ D++L+IN + + H
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE-ARHDH 930
Query: 202 AIALLQQTTGSLRLIVAREP------------------VHTKSSTSSSLNDTTLPE---- 239
A++LL + ++ L++ RE V T S T+++ LP
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 240 ---TVCWGH--VEEVELINDGSGLGFGIVGG----------KTSGVVVRTIVPGGLADRD 284
G VEE+ L G LG IVGG + GV + ++P GLA R
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
Query: 285 GRLQTGDHILKIGGTNVQGMT-SEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343
G L+ GD IL + G +V+ T E V+ +LR C + +LV RDPA PP L
Sbjct: 1051 G-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRRDPA------PPGLRELC 1102
Query: 344 VALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRI----VGYVGTSHTGEASGIYVKS 399
+ K P G+ LGI I G+ G GI++
Sbjct: 1103 I------QKAP------------------GERLGISIRGGARGHAGNPRDPTDEGIFISK 1138
Query: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
+ P AA +G ++V +++ V+ ++ G + + V++LR+ G + + + +S+ +
Sbjct: 1139 VSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDA 1198
Query: 460 PLE 462
LE
Sbjct: 1199 ALE 1201
Score = 91.3 bits (225), Expect = 8e-18
Identities = 94/349 (26%), Positives = 149/349 (42%), Gaps = 57/349 (16%)
Query: 142 TGGLGFSVVALRSQNLGKVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
TGGLG S+ + K D IF+ V A R ++ D++L +N L Q
Sbjct: 735 TGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVAL-QGAE 792
Query: 199 HQQAIALLQQTTGSLRLIVARE----PVHTKSSTSSSLNDTTLPETVCWGHVE------- 247
H +A+ L+ ++++ V RE P + + T D P G +
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPE 852
Query: 248 ---------EVELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTG 290
L GLGF I GGK S G+ V I GG A R G LQ G
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTP-----PAPAALPVA 345
D +L I G +V + +L ++ +L+ R+ G + +P P AA+
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972
Query: 346 LPTVASKG-PGSDS--------SLFETYNVELVR--KDGQSLGIRIVGYVGTSHTG---- 390
T A+ G PG S +L Y VE +R + G LG+ IVG G+ H+
Sbjct: 973 SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFG 1030
Query: 391 -EASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVL 438
+ G+++ ++P A +G ++V D+I+AV+G +++ + + V L
Sbjct: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 82.4 bits (202), Expect = 4e-15
Identities = 74/270 (27%), Positives = 120/270 (44%), Gaps = 39/270 (14%)
Query: 246 VEEVEL----INDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHI 293
+EE EL + GLG I GGK S G+ + + G A R G ++ GD +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 294 LKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----PAGDISVTPPAPA--------- 340
L++ G +QG + + LR G +V+M V R+ P +++TP P
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 341 ALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVG-TSHTGEASGIYVKS 399
+ LP + + PG +V + + + LG I G G T + +GI+V
Sbjct: 841 GGGLRLPLLPPESPGP----LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
Query: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
I G AA+ G +QV D++++++GV++ + V +L A + L L R +
Sbjct: 897 IAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER----EAGG 952
Query: 460 PLEPPSDRGTVVEPLKPPALFLTGAVETET 489
PL PPS + P A T ++ T T
Sbjct: 953 PL-PPS---PLPHSSPPTAAVATTSITTAT 978
Score = 70.1 bits (170), Expect = 2e-11
Identities = 67/224 (29%), Positives = 96/224 (42%), Gaps = 26/224 (11%)
Query: 1543 GLGLSIVG-------KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
GLG+SI G K + G+FIS + + G A G + GD++L VNG ++ A
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRV-GDKLLEVNGVALQGAEHHE 795
Query: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLV 1655
L+ A VQ+ + R R +A T + S +
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--------------ERRG 841
Query: 1656 GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSP---LGDIPVFIAMIQAS 1712
G R+ ++ G + R V LG SIAGG+GS GD +F++ I
Sbjct: 842 GGLRLPLLPPESPGP-LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIIL 1756
G A R L+VGDR++SING + H V+LL A I L
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
Score = 54.3 bits (129), Expect = 1e-06
Identities = 48/193 (24%), Positives = 87/193 (45%), Gaps = 39/193 (20%)
Query: 1185 QEKKEKRQGTAPPPMKLPPPYKALTDDSDEN--EEEDAFTDQKIRQ-------------- 1228
+E++E+ +G+ P + ++ +EN EEE+A T+++ ++
Sbjct: 659 KEEEEEEEGS---------PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSF 709
Query: 1229 --------RYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMS-----IFVVGINPEGPA 1275
A + E + + + GLG+S+AG K + IF+ ++ EGPA
Sbjct: 710 DQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPA 769
Query: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
A G +R+GD+LLE+N L G H A ++ A + V++ R + AVT P+
Sbjct: 770 ARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL 828
Query: 1336 PSSSPSSIEDQSG 1348
S ++ G
Sbjct: 829 RPEDDYSPRERRG 841
Score = 51.6 bits (122), Expect = 7e-06
Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 1675 RTVEINRELSDALGISIAGGRGSPLG------DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
R + I + + LGISI GG G D +FI+ + +G A R +L+VG R++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLE 1772
+N Q L GL+H + V LL++ G + +V D ++ A LE
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSV-GDTLTVLVCDGFEASTDAALE 1201
Score = 51.2 bits (121), Expect = 9e-06
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 9/117 (7%)
Query: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL---GD 1701
AP + G+ + +P++ + E T+ I R+ + LGISIAGG+GS D
Sbjct: 701 APSVKGVSFDQANNLLIEPAR----IEEEELTLTILRQ-TGGLGISIAGGKGSTPYKGDD 755
Query: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
+FI+ + G AAR ++VGD+++ +NG L G H + V L+ A + ++V
Sbjct: 756 EGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 51.2 bits (121), Expect = 9e-06
Identities = 56/197 (28%), Positives = 80/197 (40%), Gaps = 21/197 (10%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+IS + GP G+ + D+LLEVNG+ L G EAV L+ + R
Sbjct: 759 FISRVSEEGPAARAGV-RVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE--- 814
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDG--ELALWSPEV-------KIVELVKD 692
+ EP T P D D + E G L L PE + L +
Sbjct: 815 ---RMVEPENAVTITPLRPED---DYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARS 868
Query: 693 CKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
+GLGFSI + P + I + + G A R+G L GDR++S+N +
Sbjct: 869 ERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
Query: 751 AEAVEILKAVPPGLVHL 767
AV +L A P + L
Sbjct: 929 DHAVSLLTAASPTIALL 945
Score = 51.2 bits (121), Expect = 9e-06
Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Query: 1254 AGN-KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
AGN +D + IF+ ++P G A DGR+R+G LLE+N Q L G +H A ++++
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Query: 1313 KVKLVFIRNEDAVNQMA--VTPFPVPSSSPSSIEDQSGTEPISS 1354
+ ++ +A A V+P + + + I ++ E ISS
Sbjct: 1183 TLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISS 1226
Score = 48.5 bits (114), Expect = 6e-05
Identities = 33/82 (40%), Positives = 47/82 (57%), Gaps = 4/82 (4%)
Query: 1066 PRIVEIFREPNVS--LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
P VE R P LG+SIVGG G + G+FI +VL A ++ L+ GD
Sbjct: 999 PYPVEEIRLPRAGGPLGLSIVGGSDHSSH-PFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056
Query: 1124 KILEVSGVDLQNASHSEAVEAI 1145
+IL V+G D+++A+H EAV A+
Sbjct: 1057 RILAVNGQDVRDATHQEAVSAL 1078
Score = 48.1 bits (113), Expect = 8e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 11/115 (9%)
Query: 1065 PPRIVE--IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122
PP + E I + P LGISI GG +GIFI +V AG+ L+ G
Sbjct: 1095 PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVG 1154
Query: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV---------QSLSSTPRVIPN 1168
++LEV+ L +H EAV+ +++ G+ + +V +L +P VI N
Sbjct: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIAN 1209
Score = 45.1 bits (105), Expect = 6e-04
Identities = 57/222 (25%), Positives = 81/222 (36%), Gaps = 33/222 (14%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D ++S I GG G LQ D +L +NG+ + AVS L P L+ R
Sbjct: 889 DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
Query: 638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE-----------VKI 686
+ P S P T + T L +P V+
Sbjct: 949 ----EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
Query: 687 VELVKDCKGLGFSILDYQD----PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
+ L + LG SI+ D P + I ++ G+A RS GL GDR+++VN
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNG 1063
Query: 743 YCLDNTSLAEAVEIL-------------KAVPPGLVHLGICK 771
+ + + EAV L PPGL L I K
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQK 1105
Score = 37.7 bits (86), Expect = 0.10
Identities = 22/56 (39%), Positives = 31/56 (55%)
Query: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+P DPT I I + G A R G L G RL+ VN+ L + EAV++L++V
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
Score = 32.7 bits (73), Expect = 3.3
Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)
Query: 641 DDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVE------------ 688
++E P+ E E + +TEE+D + +P VK V
Sbjct: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
Query: 689 ----------LVKDCKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
+++ GLG SI + P I I + +G A R+ G+ GD+
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDK 779
Query: 737 LVSVNEYCLDNTSLAEAVEILK 758
L+ VN L EAVE L+
Sbjct: 780 LLEVNGVALQGAEHHEAVEALR 801
Score = 32.7 bits (73), Expect = 3.3
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
D D +IS + G G L+ LLEVN L G + EAV L+ V T++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Query: 635 CCRRLFDDEASVD 647
C EAS D
Sbjct: 1188 VCDGF---EASTD 1197
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 149 bits (376), Expect = 2e-35
Identities = 156/545 (28%), Positives = 229/545 (42%), Gaps = 126/545 (23%)
Query: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
LGISI GG+ + E GIFI +V E+ PA + ++ GDK+LEV+GV LQ A H
Sbjct: 738 LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
EAVEA++ AG VQ R++ A IT + +D +E+R G P
Sbjct: 794 HEAVEALRGAGT----AVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGLRLP 847
Query: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
+ LPP + +RQR H+ L + + GLG S+AG K
Sbjct: 848 L-LPPE-----------------SPGPLRQR--------HVACLARSERGLGFSIAGGKG 881
Query: 1259 RS-----RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
+ IFV I G A G +++GD +L IN + H +A +++ A
Sbjct: 882 STPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Query: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
+ L+ R + P P+P SSP T +++ + G+ LP
Sbjct: 942 IALLLEREAGG----PLPPSPLPHSSPP-------TAAVATTSITTATPGVPGLPSLAPS 990
Query: 1374 KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPG 1433
LA + + P V+ P G
Sbjct: 991 LLAAA--------------------------------------LEGPYPVEEIRLPRAGG 1012
Query: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN-------AIVIHEVYEEGAAARDGRLWAGDQIL 1486
LGLSIVGG D + + I +V G AAR G L GD+IL
Sbjct: 1013 P------------LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRIL 1059
Query: 1487 EVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
VNG D+R+++H+EA++AL + ++ L+V RD A E + +QK G LG+
Sbjct: 1060 AVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE------LCIQKAPGERLGI 1113
Query: 1547 SIVGKRNG----------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
SI G G G+FIS + GAA DGRL G ++L VN + + +
Sbjct: 1114 SIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEA 1173
Query: 1597 ATILK 1601
+L+
Sbjct: 1174 VQLLR 1178
Score = 122 bits (306), Expect = 3e-27
Identities = 120/379 (31%), Positives = 177/379 (46%), Gaps = 67/379 (17%)
Query: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGK-DTPLNA----IVIHEVYEEGAAAR 1475
L ++PA + +E+ + I + GLG+SI GGK TP I I V EEG AAR
Sbjct: 715 LLIEPAR---IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
Query: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD---------------- 1519
G + GD++LEVNGV L+ + H EA+ ALR V++ V+R+
Sbjct: 772 AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
Query: 1520 EAHYRDEEN------LEIFP-----------VDLQKKAGRGLGLSIVGKRNGS------- 1555
E Y E L + P V ++ RGLG SI G + +
Sbjct: 831 EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDA 890
Query: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR 1615
G+F+S I +GGAA G L GD++LS+NG D+ A + ++L A + L + R
Sbjct: 891 GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER-E 949
Query: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675
AG +S + A +S + P + GL +L PS + + P
Sbjct: 950 AGGPLPPSPLPHSSPPTAAVATTSI-TTATPGVPGLPSLA-------PSLLAAALE-GPY 1000
Query: 1676 TVEINR--ELSDALGISIAGG---RGSPLG--DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
VE R LG+SI GG P G + VFI+ + G+AAR+ L+VGDRI+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRIL 1059
Query: 1729 SINGQPLDGLSHADVVNLL 1747
++NGQ + +H + V+ L
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 93.2 bits (230), Expect = 2e-18
Identities = 109/423 (25%), Positives = 174/423 (41%), Gaps = 98/423 (23%)
Query: 98 PSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERP-------------STGG 144
P N T++ L P ED S ++ G ++ + E P S G
Sbjct: 819 PENAVTITPLRP-------EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG 871
Query: 145 LGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
LGFS+ + G IFV + G A R L+ D++L+IN + + H
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE-ARHDH 930
Query: 202 AIALLQQTTGSLRLIVAREP------------------VHTKSSTSSSLNDTTLPE---- 239
A++LL + ++ L++ RE V T S T+++ LP
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 240 ---TVCWGH--VEEVELINDGSGLGFGIVGG----------KTSGVVVRTIVPGGLADRD 284
G VEE+ L G LG IVGG + GV + ++P GLA R
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
Query: 285 GRLQTGDHILKIGGTNVQGMT-SEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343
G L+ GD IL + G +V+ T E V+ +LR C + +LV RDPA PP L
Sbjct: 1051 G-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRRDPA------PPGLRELC 1102
Query: 344 VALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRI----VGYVGTSHTGEASGIYVKS 399
+ K P G+ LGI I G+ G GI++
Sbjct: 1103 I------QKAP------------------GERLGISIRGGARGHAGNPRDPTDEGIFISK 1138
Query: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
+ P AA +G ++V +++ V+ ++ G + + V++LR+ G + + + +S+ +
Sbjct: 1139 VSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDA 1198
Query: 460 PLE 462
LE
Sbjct: 1199 ALE 1201
Score = 91.3 bits (225), Expect = 8e-18
Identities = 94/349 (26%), Positives = 149/349 (42%), Gaps = 57/349 (16%)
Query: 142 TGGLGFSVVALRSQNLGKVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
TGGLG S+ + K D IF+ V A R ++ D++L +N L Q
Sbjct: 735 TGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVAL-QGAE 792
Query: 199 HQQAIALLQQTTGSLRLIVARE----PVHTKSSTSSSLNDTTLPETVCWGHVE------- 247
H +A+ L+ ++++ V RE P + + T D P G +
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPE 852
Query: 248 ---------EVELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTG 290
L GLGF I GGK S G+ V I GG A R G LQ G
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTP-----PAPAALPVA 345
D +L I G +V + +L ++ +L+ R+ G + +P P AA+
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972
Query: 346 LPTVASKG-PGSDS--------SLFETYNVELVR--KDGQSLGIRIVGYVGTSHTG---- 390
T A+ G PG S +L Y VE +R + G LG+ IVG G+ H+
Sbjct: 973 SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFG 1030
Query: 391 -EASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVL 438
+ G+++ ++P A +G ++V D+I+AV+G +++ + + V L
Sbjct: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 82.4 bits (202), Expect = 4e-15
Identities = 74/270 (27%), Positives = 120/270 (44%), Gaps = 39/270 (14%)
Query: 246 VEEVEL----INDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHI 293
+EE EL + GLG I GGK S G+ + + G A R G ++ GD +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 294 LKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----PAGDISVTPPAPA--------- 340
L++ G +QG + + LR G +V+M V R+ P +++TP P
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 341 ALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVG-TSHTGEASGIYVKS 399
+ LP + + PG +V + + + LG I G G T + +GI+V
Sbjct: 841 GGGLRLPLLPPESPGP----LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
Query: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
I G AA+ G +QV D++++++GV++ + V +L A + L L R +
Sbjct: 897 IAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER----EAGG 952
Query: 460 PLEPPSDRGTVVEPLKPPALFLTGAVETET 489
PL PPS + P A T ++ T T
Sbjct: 953 PL-PPS---PLPHSSPPTAAVATTSITTAT 978
Score = 70.1 bits (170), Expect = 2e-11
Identities = 67/224 (29%), Positives = 96/224 (42%), Gaps = 26/224 (11%)
Query: 1543 GLGLSIVG-------KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
GLG+SI G K + G+FIS + + G A G + GD++L VNG ++ A
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRV-GDKLLEVNGVALQGAEHHE 795
Query: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLV 1655
L+ A VQ+ + R R +A T + S +
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--------------ERRG 841
Query: 1656 GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSP---LGDIPVFIAMIQAS 1712
G R+ ++ G + R V LG SIAGG+GS GD +F++ I
Sbjct: 842 GGLRLPLLPPESPGP-LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIIL 1756
G A R L+VGDR++SING + H V+LL A I L
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
Score = 54.3 bits (129), Expect = 1e-06
Identities = 48/193 (24%), Positives = 87/193 (45%), Gaps = 39/193 (20%)
Query: 1185 QEKKEKRQGTAPPPMKLPPPYKALTDDSDEN--EEEDAFTDQKIRQ-------------- 1228
+E++E+ +G+ P + ++ +EN EEE+A T+++ ++
Sbjct: 659 KEEEEEEEGS---------PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSF 709
Query: 1229 --------RYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMS-----IFVVGINPEGPA 1275
A + E + + + GLG+S+AG K + IF+ ++ EGPA
Sbjct: 710 DQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPA 769
Query: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
A G +R+GD+LLE+N L G H A ++ A + V++ R + AVT P+
Sbjct: 770 ARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL 828
Query: 1336 PSSSPSSIEDQSG 1348
S ++ G
Sbjct: 829 RPEDDYSPRERRG 841
Score = 51.6 bits (122), Expect = 7e-06
Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 1675 RTVEINRELSDALGISIAGGRGSPLG------DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
R + I + + LGISI GG G D +FI+ + +G A R +L+VG R++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLE 1772
+N Q L GL+H + V LL++ G + +V D ++ A LE
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSV-GDTLTVLVCDGFEASTDAALE 1201
Score = 51.2 bits (121), Expect = 9e-06
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 9/117 (7%)
Query: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL---GD 1701
AP + G+ + +P++ + E T+ I R+ + LGISIAGG+GS D
Sbjct: 701 APSVKGVSFDQANNLLIEPAR----IEEEELTLTILRQ-TGGLGISIAGGKGSTPYKGDD 755
Query: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
+FI+ + G AAR ++VGD+++ +NG L G H + V L+ A + ++V
Sbjct: 756 EGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 51.2 bits (121), Expect = 9e-06
Identities = 56/197 (28%), Positives = 80/197 (40%), Gaps = 21/197 (10%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+IS + GP G+ + D+LLEVNG+ L G EAV L+ + R
Sbjct: 759 FISRVSEEGPAARAGV-RVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE--- 814
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDG--ELALWSPEV-------KIVELVKD 692
+ EP T P D D + E G L L PE + L +
Sbjct: 815 ---RMVEPENAVTITPLRPED---DYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARS 868
Query: 693 CKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
+GLGFSI + P + I + + G A R+G L GDR++S+N +
Sbjct: 869 ERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
Query: 751 AEAVEILKAVPPGLVHL 767
AV +L A P + L
Sbjct: 929 DHAVSLLTAASPTIALL 945
Score = 51.2 bits (121), Expect = 9e-06
Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Query: 1254 AGN-KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
AGN +D + IF+ ++P G A DGR+R+G LLE+N Q L G +H A ++++
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Query: 1313 KVKLVFIRNEDAVNQMA--VTPFPVPSSSPSSIEDQSGTEPISS 1354
+ ++ +A A V+P + + + I ++ E ISS
Sbjct: 1183 TLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISS 1226
Score = 48.5 bits (114), Expect = 6e-05
Identities = 33/82 (40%), Positives = 47/82 (57%), Gaps = 4/82 (4%)
Query: 1066 PRIVEIFREPNVS--LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
P VE R P LG+SIVGG G + G+FI +VL A ++ L+ GD
Sbjct: 999 PYPVEEIRLPRAGGPLGLSIVGGSDHSSH-PFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056
Query: 1124 KILEVSGVDLQNASHSEAVEAI 1145
+IL V+G D+++A+H EAV A+
Sbjct: 1057 RILAVNGQDVRDATHQEAVSAL 1078
Score = 48.1 bits (113), Expect = 8e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 11/115 (9%)
Query: 1065 PPRIVE--IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122
PP + E I + P LGISI GG +GIFI +V AG+ L+ G
Sbjct: 1095 PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVG 1154
Query: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV---------QSLSSTPRVIPN 1168
++LEV+ L +H EAV+ +++ G+ + +V +L +P VI N
Sbjct: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIAN 1209
Score = 45.1 bits (105), Expect = 6e-04
Identities = 57/222 (25%), Positives = 81/222 (36%), Gaps = 33/222 (14%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D ++S I GG G LQ D +L +NG+ + AVS L P L+ R
Sbjct: 889 DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
Query: 638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE-----------VKI 686
+ P S P T + T L +P V+
Sbjct: 949 ----EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
Query: 687 VELVKDCKGLGFSILDYQD----PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
+ L + LG SI+ D P + I ++ G+A RS GL GDR+++VN
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNG 1063
Query: 743 YCLDNTSLAEAVEIL-------------KAVPPGLVHLGICK 771
+ + + EAV L PPGL L I K
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQK 1105
Score = 37.7 bits (86), Expect = 0.10
Identities = 22/56 (39%), Positives = 31/56 (55%)
Query: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+P DPT I I + G A R G L G RL+ VN+ L + EAV++L++V
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
Score = 32.7 bits (73), Expect = 3.3
Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)
Query: 641 DDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVE------------ 688
++E P+ E E + +TEE+D + +P VK V
Sbjct: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
Query: 689 ----------LVKDCKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
+++ GLG SI + P I I + +G A R+ G+ GD+
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDK 779
Query: 737 LVSVNEYCLDNTSLAEAVEILK 758
L+ VN L EAVE L+
Sbjct: 780 LLEVNGVALQGAEHHEAVEALR 801
Score = 32.7 bits (73), Expect = 3.3
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
D D +IS + G G L+ LLEVN L G + EAV L+ V T++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Query: 635 CCRRLFDDEASVD 647
C EAS D
Sbjct: 1188 VCDGF---EASTD 1197
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 139 bits (350), Expect = 2e-32
Identities = 110/326 (33%), Positives = 158/326 (48%), Gaps = 28/326 (8%)
Query: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
I + +G SGLG SI GG D P ++I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK-- 1551
R+ +H +A+ AL++ VRL V R R + +I + L K +GLG SI G
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKR-----RKPVSEKIMEIKL-IKGPKGLGFSIAGGVG 338
Query: 1552 ----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
+ ++++ I++GGAA DG+L GD++L+VN + + E T LK V
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
Query: 1608 QLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKN 1667
L++ + + + S Q + PS G Q R S S+
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPS---SFLG-QTPASPARYSPVSKAV 454
Query: 1668 SGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
G D EPR V ++R S LG +I GG +FI+ I A G A + +L+ G
Sbjct: 455 LGDDEITREPRKVVLHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKG 509
Query: 1725 DRIVSINGQPLDGLSHADVVNLLKNA 1750
DRI+S+N L SH LKNA
Sbjct: 510 DRIISVNSVDLRAASHEQAAAALKNA 535
Score = 109 bits (272), Expect = 3e-23
Identities = 92/352 (26%), Positives = 158/352 (44%), Gaps = 70/352 (19%)
Query: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
+ E I +ER ++G LGFS+ + ++G IF+ + G A +D RL+ ND IL +
Sbjct: 221 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
Query: 189 NHTPLDQNISHQQAIALLQQTTGSLRLIVAR-EPVHTKSSTSSSLNDTTLPETVCWGHVE 247
N + ++++H +A+ L++ +RL V R +PV K +
Sbjct: 280 NEVDV-RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK--------------------IM 318
Query: 248 EVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
E++LI GLGF I GG + + V I+ GG A +DG+LQ GD +L +
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 301 VQGMTSEQVAQVLRNCGNSVRMLVAR---------------------------DPAGDIS 333
++ +T E+ L+N + V + VA+ P+ +
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLG 438
Query: 334 VTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEAS 393
TP +PA + SK D + ++ + LG IVG GE
Sbjct: 439 QTPASPARY-----SPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG----GEDGE-- 487
Query: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
GI++ I+ G A +G ++ D+I++V+ V+++ ++ L+NAGQ V
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Score = 103 bits (256), Expect = 2e-21
Identities = 107/379 (28%), Positives = 164/379 (43%), Gaps = 61/379 (16%)
Query: 1198 PMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNK 1257
P PPP TD + T + AD E I LE+ +GLG S+AG
Sbjct: 193 PQANPPPVLVNTDSLE--------TPTYVNGTDADY--EYEEITLERGNSGLGFSIAGGT 242
Query: 1258 DRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
D + SIF+ I G AA DGR+R+ D +L +N + +H A +K A S
Sbjct: 243 DNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSI 302
Query: 1314 VKLVFIRNEDAVNQ--MAVTPFPVPSSSPSSIEDQSGTEPI---------------SSEE 1356
V+L +++ V++ M + P SI G + I ++ +
Sbjct: 303 VRL-YVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHK 361
Query: 1357 DGSVEVGIKQLP------ESESFKLAVSQMKQQK--------YPTKVSFSSQEIP--LAP 1400
DG +++G K L E + + AV+ +K PT + + P +
Sbjct: 362 DGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITN 421
Query: 1401 ASSY----HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIE-----ISKGRSGLGLSI 1451
+SS H + + F G +P P + ++ E+ E + +G +GLG +I
Sbjct: 422 SSSQPVDNHVSPSSFLGQTP-ASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
Query: 1452 VGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK 1511
VGG+D I I + G A G L GD+I+ VN VDLR +SHE+A AL+ Q
Sbjct: 481 VGGEDG--EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA 538
Query: 1512 VRLVV-YRDEAHYRDEENL 1529
V +V YR E + R E +
Sbjct: 539 VTIVAQYRPEEYSRFEAKI 557
Score = 82.8 bits (203), Expect = 3e-15
Identities = 62/221 (28%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I+V + G A +D +L+ D++LA+N+ L++ ++H++
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE-VTHEE 386
Query: 202 AIALLQQTTGSLRLIVAR--------------------EPVHTKSSTSSSLNDT------ 235
A+ L+ T+ + L VA+ +PV S SS L T
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
Query: 236 -------TLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRL 287
L + +V L +GLGF IVGG+ G+ + I+ GG AD G L
Sbjct: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 288 QTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
+ GD I+ + +++ + EQ A L+N G +V ++ P
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
Score = 81.6 bits (200), Expect = 6e-15
Identities = 88/363 (24%), Positives = 137/363 (37%), Gaps = 65/363 (17%)
Query: 337 PAPAALPVALPTVASKGP-----GSDSSLFETY---------NVELVRKDGQS-LGIRIV 381
P PA V LPT+ P +DS TY E+ + G S LG I
Sbjct: 180 PVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIA 239
Query: 382 GYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNA 441
G H G+ S I++ II G AA +G ++VND I+ V+ V+++ + VE L+ A
Sbjct: 240 GGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
Query: 442 GQVVHLTLVRRKTSS---------------------STSPLEPPSDRGTVVEPL------ 474
G +V L + RRK S P D V +
Sbjct: 300 GSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 359
Query: 475 -KPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEK----------VPDSP 523
K L + + NV E+ +E + LKN + K+ K P
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Query: 524 ENELKSRWENLLGPD--------YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVD 575
N +N + P + + + D E+ + + + +H G+ +
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFN 479
Query: 576 SFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPF 631
G +IS I++GGP D G L+ D ++ VN + L S +A + LK
Sbjct: 480 IVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Query: 632 TLV 634
T+V
Sbjct: 540 TIV 542
Score = 80.1 bits (196), Expect = 2e-14
Identities = 67/255 (26%), Positives = 110/255 (43%), Gaps = 38/255 (14%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++ + P LG SI GG + + G I++ +++E A K L+ GDK+
Sbjct: 320 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQ--D 1183
L V+ V L+ +H EAV A+KN + F+ ++ + N IT + +Q D
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSD---FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 1184 TQEKKEKRQGTAP-PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
G P P + P KA+ D ++ E + L
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDD-------------------EITREPRKVVL 469
Query: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
+ GLG ++ G +D IF+ I GPA G +R GD ++ +N+ L SH+
Sbjct: 470 HRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 1303 ASAIIKTAPSKVKLV 1317
A+A +K A V +V
Sbjct: 528 AAAALKNAGQAVTIV 542
Score = 72.8 bits (177), Expect = 3e-12
Identities = 61/235 (25%), Positives = 98/235 (41%), Gaps = 62/235 (26%)
Query: 1538 KKAGRGLGLSIVGKRNG------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
++ GLG SI G + S +FI+ I+ GGAA DGRL D IL VN D+R+
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
+ LK A +V+L + R + S
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVS--------------------------------- 314
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
+ ++ K + P LG SIAGG G+ GD +++ I
Sbjct: 315 EKIMEIKLIKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 353
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
G A + KL++GD+++++N L+ ++H + V LKN + L+V T++
Sbjct: 354 IEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSM 408
Score = 63.2 bits (152), Expect = 2e-09
Identities = 38/96 (39%), Positives = 52/96 (54%), Gaps = 18/96 (18%)
Query: 1070 EIFREP--------NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKT 1121
EI REP + LG +IVGG E+ +GIFI +L PA + L+
Sbjct: 459 EITREPRKVVLHRGSTGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRK 508
Query: 1122 GDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
GD+I+ V+ VDL+ ASH +A A+KNAG V + Q
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Score = 60.5 bits (145), Expect = 1e-08
Identities = 79/354 (22%), Positives = 128/354 (36%), Gaps = 101/354 (28%)
Query: 425 NIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPL-----KPPAL 479
N+ GF +H + ++ V+ + P+ P TV+ P PP L
Sbjct: 147 NVHGFVSHSHISPIKPTEAVLP-----SPPTVPVIPVLPVPAENTVILPTIPQANPPPVL 201
Query: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
T ++ET T V+G D + + TL+ N G +
Sbjct: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNS-------------------------GLGF 236
Query: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQ 599
+ T + I DD+ + +I+ I++GG G L+
Sbjct: 237 SIAGGTDNPHIGDDSSI-------------------------FITKIITGGAAAQDGRLR 271
Query: 600 PEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPET 659
D +L VN + + + +AV LKE L RR P +
Sbjct: 272 VNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRK-----------------PVS 314
Query: 660 EVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD-YQDPLDPTRSVIVIRS 718
E ++ ++L+K KGLGFSI + P + I +
Sbjct: 315 E----------------------KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK 352
Query: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
++ G A + G L GD+L++VN CL+ + EAV LK V+L + KP
Sbjct: 353 IIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT-SDFVYLKVAKP 405
Score = 51.6 bits (122), Expect = 7e-06
Identities = 62/247 (25%), Positives = 100/247 (40%), Gaps = 42/247 (17%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D Y++ I+ GG G LQ D+LL VN + L + EAV+ LK L +
Sbjct: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK 404
Query: 638 --RLFDDEASVDEPRRTETSLPETEVDHNMDVNTE-EDDDGELALWSP------------ 682
++ ++ +S P VD+++ ++ A +SP
Sbjct: 405 PTSMYMNDGYAPPDITNSSSQP---VDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEIT 461
Query: 683 -EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + V L + GLGF+I+ +D I I ++A G A+ SG L GDR++SVN
Sbjct: 462 REPRKVVLHRGSTGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDRIISVN 516
Query: 742 EYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIH 801
L S +A LK N ++ I+ E+ + F IH
Sbjct: 517 SVDLRAASHEQAAAALK------------------NAGQAVTIVAQYRPEEYSRFEAKIH 558
Query: 802 DINSSLI 808
D+ ++
Sbjct: 559 DLREQMM 565
Score = 47.8 bits (112), Expect = 1e-04
Identities = 30/82 (36%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
N LG SI GG G++ IFI +++ A + L+ D IL V+ VD+++
Sbjct: 231 NSGLGFSIAGGTD---NPHIGDD-SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
+HS+AVEA+K AG+ V V+
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVK 308
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 139 bits (350), Expect = 2e-32
Identities = 110/326 (33%), Positives = 158/326 (48%), Gaps = 28/326 (8%)
Query: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
I + +G SGLG SI GG D P ++I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK-- 1551
R+ +H +A+ AL++ VRL V R R + +I + L K +GLG SI G
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKR-----RKPVSEKIMEIKL-IKGPKGLGFSIAGGVG 338
Query: 1552 ----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
+ ++++ I++GGAA DG+L GD++L+VN + + E T LK V
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
Query: 1608 QLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKN 1667
L++ + + + S Q + PS G Q R S S+
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPS---SFLG-QTPASPARYSPVSKAV 454
Query: 1668 SGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
G D EPR V ++R S LG +I GG +FI+ I A G A + +L+ G
Sbjct: 455 LGDDEITREPRKVVLHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKG 509
Query: 1725 DRIVSINGQPLDGLSHADVVNLLKNA 1750
DRI+S+N L SH LKNA
Sbjct: 510 DRIISVNSVDLRAASHEQAAAALKNA 535
Score = 109 bits (272), Expect = 3e-23
Identities = 92/352 (26%), Positives = 158/352 (44%), Gaps = 70/352 (19%)
Query: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
+ E I +ER ++G LGFS+ + ++G IF+ + G A +D RL+ ND IL +
Sbjct: 221 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
Query: 189 NHTPLDQNISHQQAIALLQQTTGSLRLIVAR-EPVHTKSSTSSSLNDTTLPETVCWGHVE 247
N + ++++H +A+ L++ +RL V R +PV K +
Sbjct: 280 NEVDV-RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK--------------------IM 318
Query: 248 EVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
E++LI GLGF I GG + + V I+ GG A +DG+LQ GD +L +
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 301 VQGMTSEQVAQVLRNCGNSVRMLVAR---------------------------DPAGDIS 333
++ +T E+ L+N + V + VA+ P+ +
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLG 438
Query: 334 VTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEAS 393
TP +PA + SK D + ++ + LG IVG GE
Sbjct: 439 QTPASPARY-----SPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG----GEDGE-- 487
Query: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
GI++ I+ G A +G ++ D+I++V+ V+++ ++ L+NAGQ V
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Score = 103 bits (256), Expect = 2e-21
Identities = 107/379 (28%), Positives = 164/379 (43%), Gaps = 61/379 (16%)
Query: 1198 PMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNK 1257
P PPP TD + T + AD E I LE+ +GLG S+AG
Sbjct: 193 PQANPPPVLVNTDSLE--------TPTYVNGTDADY--EYEEITLERGNSGLGFSIAGGT 242
Query: 1258 DRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
D + SIF+ I G AA DGR+R+ D +L +N + +H A +K A S
Sbjct: 243 DNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSI 302
Query: 1314 VKLVFIRNEDAVNQ--MAVTPFPVPSSSPSSIEDQSGTEPI---------------SSEE 1356
V+L +++ V++ M + P SI G + I ++ +
Sbjct: 303 VRL-YVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHK 361
Query: 1357 DGSVEVGIKQLP------ESESFKLAVSQMKQQK--------YPTKVSFSSQEIP--LAP 1400
DG +++G K L E + + AV+ +K PT + + P +
Sbjct: 362 DGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITN 421
Query: 1401 ASSY----HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIE-----ISKGRSGLGLSI 1451
+SS H + + F G +P P + ++ E+ E + +G +GLG +I
Sbjct: 422 SSSQPVDNHVSPSSFLGQTP-ASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
Query: 1452 VGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK 1511
VGG+D I I + G A G L GD+I+ VN VDLR +SHE+A AL+ Q
Sbjct: 481 VGGEDG--EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQA 538
Query: 1512 VRLVV-YRDEAHYRDEENL 1529
V +V YR E + R E +
Sbjct: 539 VTIVAQYRPEEYSRFEAKI 557
Score = 82.8 bits (203), Expect = 3e-15
Identities = 62/221 (28%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I+V + G A +D +L+ D++LA+N+ L++ ++H++
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE-VTHEE 386
Query: 202 AIALLQQTTGSLRLIVAR--------------------EPVHTKSSTSSSLNDT------ 235
A+ L+ T+ + L VA+ +PV S SS L T
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
Query: 236 -------TLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRL 287
L + +V L +GLGF IVGG+ G+ + I+ GG AD G L
Sbjct: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 288 QTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
+ GD I+ + +++ + EQ A L+N G +V ++ P
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
Score = 81.6 bits (200), Expect = 6e-15
Identities = 88/363 (24%), Positives = 137/363 (37%), Gaps = 65/363 (17%)
Query: 337 PAPAALPVALPTVASKGP-----GSDSSLFETY---------NVELVRKDGQS-LGIRIV 381
P PA V LPT+ P +DS TY E+ + G S LG I
Sbjct: 180 PVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIA 239
Query: 382 GYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNA 441
G H G+ S I++ II G AA +G ++VND I+ V+ V+++ + VE L+ A
Sbjct: 240 GGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
Query: 442 GQVVHLTLVRRKTSS---------------------STSPLEPPSDRGTVVEPL------ 474
G +V L + RRK S P D V +
Sbjct: 300 GSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 359
Query: 475 -KPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEK----------VPDSP 523
K L + + NV E+ +E + LKN + K+ K P
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Query: 524 ENELKSRWENLLGPD--------YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVD 575
N +N + P + + + D E+ + + + +H G+ +
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFN 479
Query: 576 SFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPF 631
G +IS I++GGP D G L+ D ++ VN + L S +A + LK
Sbjct: 480 IVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Query: 632 TLV 634
T+V
Sbjct: 540 TIV 542
Score = 80.1 bits (196), Expect = 2e-14
Identities = 67/255 (26%), Positives = 110/255 (43%), Gaps = 38/255 (14%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++ + P LG SI GG + + G I++ +++E A K L+ GDK+
Sbjct: 320 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQ--D 1183
L V+ V L+ +H EAV A+KN + F+ ++ + N IT + +Q D
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSD---FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 1184 TQEKKEKRQGTAP-PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
G P P + P KA+ D ++ E + L
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDD-------------------EITREPRKVVL 469
Query: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
+ GLG ++ G +D IF+ I GPA G +R GD ++ +N+ L SH+
Sbjct: 470 HRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 1303 ASAIIKTAPSKVKLV 1317
A+A +K A V +V
Sbjct: 528 AAAALKNAGQAVTIV 542
Score = 72.8 bits (177), Expect = 3e-12
Identities = 61/235 (25%), Positives = 98/235 (41%), Gaps = 62/235 (26%)
Query: 1538 KKAGRGLGLSIVGKRNG------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
++ GLG SI G + S +FI+ I+ GGAA DGRL D IL VN D+R+
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
+ LK A +V+L + R + S
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVS--------------------------------- 314
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
+ ++ K + P LG SIAGG G+ GD +++ I
Sbjct: 315 EKIMEIKLIKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 353
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
G A + KL++GD+++++N L+ ++H + V LKN + L+V T++
Sbjct: 354 IEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSM 408
Score = 63.2 bits (152), Expect = 2e-09
Identities = 38/96 (39%), Positives = 52/96 (54%), Gaps = 18/96 (18%)
Query: 1070 EIFREP--------NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKT 1121
EI REP + LG +IVGG E+ +GIFI +L PA + L+
Sbjct: 459 EITREPRKVVLHRGSTGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRK 508
Query: 1122 GDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
GD+I+ V+ VDL+ ASH +A A+KNAG V + Q
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Score = 60.5 bits (145), Expect = 1e-08
Identities = 79/354 (22%), Positives = 128/354 (36%), Gaps = 101/354 (28%)
Query: 425 NIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPL-----KPPAL 479
N+ GF +H + ++ V+ + P+ P TV+ P PP L
Sbjct: 147 NVHGFVSHSHISPIKPTEAVLP-----SPPTVPVIPVLPVPAENTVILPTIPQANPPPVL 201
Query: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
T ++ET T V+G D + + TL+ N G +
Sbjct: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNS-------------------------GLGF 236
Query: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQ 599
+ T + I DD+ + +I+ I++GG G L+
Sbjct: 237 SIAGGTDNPHIGDDSSI-------------------------FITKIITGGAAAQDGRLR 271
Query: 600 PEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPET 659
D +L VN + + + +AV LKE L RR P +
Sbjct: 272 VNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRK-----------------PVS 314
Query: 660 EVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD-YQDPLDPTRSVIVIRS 718
E ++ ++L+K KGLGFSI + P + I +
Sbjct: 315 E----------------------KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK 352
Query: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
++ G A + G L GD+L++VN CL+ + EAV LK V+L + KP
Sbjct: 353 IIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT-SDFVYLKVAKP 405
Score = 51.6 bits (122), Expect = 7e-06
Identities = 62/247 (25%), Positives = 100/247 (40%), Gaps = 42/247 (17%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D Y++ I+ GG G LQ D+LL VN + L + EAV+ LK L +
Sbjct: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK 404
Query: 638 --RLFDDEASVDEPRRTETSLPETEVDHNMDVNTE-EDDDGELALWSP------------ 682
++ ++ +S P VD+++ ++ A +SP
Sbjct: 405 PTSMYMNDGYAPPDITNSSSQP---VDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEIT 461
Query: 683 -EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + V L + GLGF+I+ +D I I ++A G A+ SG L GDR++SVN
Sbjct: 462 REPRKVVLHRGSTGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDRIISVN 516
Query: 742 EYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIH 801
L S +A LK N ++ I+ E+ + F IH
Sbjct: 517 SVDLRAASHEQAAAALK------------------NAGQAVTIVAQYRPEEYSRFEAKIH 558
Query: 802 DINSSLI 808
D+ ++
Sbjct: 559 DLREQMM 565
Score = 47.8 bits (112), Expect = 1e-04
Identities = 30/82 (36%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
N LG SI GG G++ IFI +++ A + L+ D IL V+ VD+++
Sbjct: 231 NSGLGFSIAGGTD---NPHIGDD-SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
+HS+AVEA+K AG+ V V+
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVK 308
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
Length = 767
Score = 135 bits (340), Expect = 4e-31
Identities = 107/331 (32%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
I + +G SGLG SI GG D P +I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
R +H A+ AL++ VRL V R + +++ K +GLG SI G
Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLI------KGPKGLGFSIAGGVG 222
Query: 1554 G------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
+ ++++ I++GGAA DGRL GD+IL+VN + + E LK +V
Sbjct: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
Query: 1608 QLEIGRLRAGSWTSAR-----TTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSD 1662
L++ + + + TTS + + +HSS + P +R S
Sbjct: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTA---MTPTSPRRYSP 339
Query: 1663 PSQKNSGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
++ G + EPR + I+R S LG +I GG +FI+ I A G A +
Sbjct: 340 VAKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSG 394
Query: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
+L+ GD+I+S+NG L SH LKNA
Sbjct: 395 ELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
Score = 120 bits (302), Expect = 9e-27
Identities = 101/399 (25%), Positives = 162/399 (40%), Gaps = 84/399 (21%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + + + I+PGG A +DGRL+ D IL +
Sbjct: 107 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V+ +T + L+ G+ VR+ V R PPA + + L KGP
Sbjct: 167 DVREVTHSAAVEALKEAGSIVRLYVMRRK-------PPAEKVMEIKL----IKGP----- 210
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G VG H + IYV II G AA+ +G +Q+ DKI+
Sbjct: 211 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
AV+ V ++ + D V L+N VV+L + + + + PP + + L
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL----- 311
Query: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
D EI S + L + + + P
Sbjct: 312 ---------------DNEI-----------------------SHSSYLGTDYPTAMTPTS 333
Query: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTL 595
+ + + + ++ + + + IH G+ + G +IS I++GGP D
Sbjct: 334 PRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLS 393
Query: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
G L+ D++L VNG+ L S +A LK T++
Sbjct: 394 GELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432
Score = 115 bits (289), Expect = 3e-25
Identities = 134/523 (25%), Positives = 214/523 (40%), Gaps = 75/523 (14%)
Query: 1184 TQEKKEKRQGTAPPPMKLPP---PYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHII 1240
++ +K + Q PP++ P P +A + N + +++ + E I
Sbjct: 50 SESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEI 109
Query: 1241 ELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
LE+ +GLG S+AG D + SIF+ I P G AA DGR+R+ D +L +N +
Sbjct: 110 TLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 169
Query: 1297 GRSHQNASAIIKTAPSKVKLVFIRNEDAVNQ-MAVTPFPVPSSSPSSIEDQSGTEPI--- 1352
+H A +K A S V+L +R + + M + P SI G + I
Sbjct: 170 EVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGD 229
Query: 1353 ------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQ--------KYP 1386
++ +DG +++G K L E + AV+ +K P
Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
Query: 1387 TKVSFSSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPAT----CPI--------- 1430
+ S P +SY + + Y G P ++ P + P+
Sbjct: 290 SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEED 349
Query: 1431 VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNG 1490
+P + I I +G +GLG +IVGG+D I I + G A G L GDQIL VNG
Sbjct: 350 IPREPRRIVIHRGSTGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQILSVNG 407
Query: 1491 VDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIV 1549
VDLRN+SHE+A AL+ Q V ++ Y+ E + R E + L + G G + +
Sbjct: 408 VDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLM-NSSLGSGTASL 466
Query: 1550 GKRNGSGVFISDIVKGGAADLDGRLIQ------GDQILSVNGED--------MRNASQET 1595
G +I + G L Q GD + ++ D + + S+
Sbjct: 467 RSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETD 526
Query: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
+ + + + E RL+A W S S SQG + S S
Sbjct: 527 DIGFIPSKRRVERREWSRLKAKDWGS----SSGSQGREDSVLS 565
Score = 103 bits (258), Expect = 1e-21
Identities = 96/354 (27%), Positives = 157/354 (44%), Gaps = 68/354 (19%)
Query: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
+ E I +ER ++G LGFS+ + ++G IF+ + PG A +D RL+ ND IL +
Sbjct: 105 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV 163
Query: 189 NHTPLDQNISHQQAIALLQQTTGSLRL-IVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
N + + ++H A+ L++ +RL ++ R+P K V
Sbjct: 164 NEVDV-REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK--------------------VM 202
Query: 248 EVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
E++LI GLGF I GG + + V I+ GG A +DGRLQ GD IL +
Sbjct: 203 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 262
Query: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI--SVTPP--------------------- 337
++ + E L+N + V + VA+ + S PP
Sbjct: 263 LEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 322
Query: 338 --APAALPVALP----TVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
P A+ P VA G + E + ++ + LG IVG GE
Sbjct: 323 TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRI-VIHRGSTGLGFNIVG----GEDGE 377
Query: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
GI++ I+ G A +G ++ D+I++V+GV+++ ++ L+NAGQ V
Sbjct: 378 --GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
Score = 80.1 bits (196), Expect = 2e-14
Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 26/252 (10%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++ + P LG SI GG + + G I++ +++E A K L+ GDKI
Sbjct: 204 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQ 1185
L V+ V L++ H +AV A+KN + VV++ + S + + + +Q+ D +
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
Query: 1186 EKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD 1245
GT P P + + + + E+ D+P E I + +
Sbjct: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE------------DIPREPRRIVIHRG 362
Query: 1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
GLG ++ G +D IF+ I GPA G +R GD++L +N L SH+ A+
Sbjct: 363 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 1306 IIKTAPSKVKLV 1317
+K A V ++
Sbjct: 421 ALKNAGQTVTII 432
Score = 77.0 bits (188), Expect = 2e-13
Identities = 63/234 (26%), Positives = 108/234 (46%), Gaps = 57/234 (24%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I+V + G A +D RL+ D+ILA+N L+ ++ H+
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE-DVMHED 270
Query: 202 AIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVE----------- 250
A+A L+ T + L VA+ +++ L+D+ P + + + ++
Sbjct: 271 AVAALKNTYDVVYLKVAKP-------SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 323
Query: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
+I+ GS GLGF IVGG+ G+ +
Sbjct: 324 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 383
Query: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
I+ GG AD G L+ GD IL + G +++ + EQ A L+N G +V ++ P
Sbjct: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 437
Score = 68.2 bits (165), Expect = 7e-11
Identities = 41/92 (44%), Positives = 54/92 (58%), Gaps = 11/92 (11%)
Query: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
PR + I R + LG +IVGG E+ +GIFI +L PA + L+ GD+I
Sbjct: 354 PRRIVIHRG-STGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRKGDQI 402
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
L V+GVDL+NASH +A A+KNAG V I Q
Sbjct: 403 LSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 55.5 bits (132), Expect = 5e-07
Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 2/79 (2%)
Query: 1687 LGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVV 1744
LG SIAGG G+ GD +++ I G A + +L++GD+I+++N L+ + H D V
Sbjct: 213 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272
Query: 1745 NLLKNAYGRIILQVVADTN 1763
LKN Y + L+V +N
Sbjct: 273 AALKNTYDVVYLKVAKPSN 291
Score = 53.5 bits (127), Expect = 2e-06
Identities = 65/258 (25%), Positives = 98/258 (37%), Gaps = 58/258 (22%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE----------- 626
D Y++ I+ GG G LQ D++L VN + L +AV+ LK
Sbjct: 229 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 288
Query: 627 ----------VPPPFTLVCCRRLFDDEAS------VDEPRRTETSLPETEVDHNMDVNTE 670
PP T + L D+E S D P + P D+ E
Sbjct: 289 PSNAYLSDSYAPPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE 347
Query: 671 EDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGG 730
ED E + + + + GLGF+I+ +D I I ++A G A+ SG
Sbjct: 348 ED-------IPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGE 395
Query: 731 LLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSN 790
L GD+++SVN L N S +A LK N ++ I+
Sbjct: 396 LRKGDQILSVNGVDLRNASHEQAAIALK------------------NAGQTVTIIAQYKP 437
Query: 791 EDKTEFSGTIHDINSSLI 808
E+ + F IHD+ L+
Sbjct: 438 EEYSRFEAKIHDLREQLM 455
Score = 52.0 bits (123), Expect = 5e-06
Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 17/147 (11%)
Query: 1008 RREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPERE-EGEGEETPNFSHWGPP 1066
R + ED P +H + ++A++ +++ TDT E P E + G E G
Sbjct: 56 RYQDEDTPPLEHSPAHLPNQANSPPVIVN----TDTLEAPGYELQVNGTE-------GEM 104
Query: 1067 RIVEIFREP-NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
EI E N LG SI GG G++ IFI +++ A + L+ D I
Sbjct: 105 EYEEITLERGNSGLGFSIAGGTD---NPHIGDD-PSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
L V+ VD++ +HS AVEA+K AG+ V
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIV 187
Score = 45.8 bits (107), Expect = 4e-04
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L+ D +L VN + + + AV LKE L RR
Sbjct: 138 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-- 195
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
P E +V ++L+K KGLGFSI
Sbjct: 196 ---------------PPAE----------------------KVMEIKLIKGPKGLGFSIA 218
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I + ++ G A + G L GD++++VN L++ +AV LK
Sbjct: 219 GGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 278
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 279 -YDVVYLKVAKP 289
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 6/92 (6%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
R+ I I R STG LGF++V IF+ + G AD L++ DQIL++N
Sbjct: 352 REPRRIVIHRGSTG-LGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVN 406
Query: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
L +N SH+QA L+ ++ +I +P
Sbjct: 407 GVDL-RNASHEQAAIALKNAGQTVTIIAQYKP 437
Score = 32.7 bits (73), Expect = 3.3
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + + L + GLGFSI D P I I ++ G A + G L D ++ VN
Sbjct: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
Query: 742 EYCLDNTSLAEAVEILK 758
E + + + AVE LK
Sbjct: 165 EVDVREVTHSAAVEALK 181
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 135 bits (340), Expect = 4e-31
Identities = 107/331 (32%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
I + +G SGLG SI GG D P +I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
R +H A+ AL++ VRL V R + +++ K +GLG SI G
Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLI------KGPKGLGFSIAGGVG 176
Query: 1554 G------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
+ ++++ I++GGAA DGRL GD+IL+VN + + E LK +V
Sbjct: 177 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236
Query: 1608 QLEIGRLRAGSWTSAR-----TTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSD 1662
L++ + + + TTS + + +HSS + P +R S
Sbjct: 237 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTA---MTPTSPRRYSP 293
Query: 1663 PSQKNSGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
++ G + EPR + I+R S LG +I GG +FI+ I A G A +
Sbjct: 294 VAKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSG 348
Query: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
+L+ GD+I+S+NG L SH LKNA
Sbjct: 349 ELRKGDQILSVNGVDLRNASHEQAAIALKNA 379
Score = 120 bits (302), Expect = 9e-27
Identities = 101/399 (25%), Positives = 162/399 (40%), Gaps = 84/399 (21%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + + + I+PGG A +DGRL+ D IL +
Sbjct: 61 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V+ +T + L+ G+ VR+ V R PPA + + L KGP
Sbjct: 121 DVREVTHSAAVEALKEAGSIVRLYVMRRK-------PPAEKVMEIKL----IKGP----- 164
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G VG H + IYV II G AA+ +G +Q+ DKI+
Sbjct: 165 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
AV+ V ++ + D V L+N VV+L + + + + PP + + L
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL----- 265
Query: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
D EI S + L + + + P
Sbjct: 266 ---------------DNEI-----------------------SHSSYLGTDYPTAMTPTS 287
Query: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTL 595
+ + + + ++ + + + IH G+ + G +IS I++GGP D
Sbjct: 288 PRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLS 347
Query: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
G L+ D++L VNG+ L S +A LK T++
Sbjct: 348 GELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386
Score = 115 bits (288), Expect = 4e-25
Identities = 126/468 (26%), Positives = 193/468 (41%), Gaps = 72/468 (15%)
Query: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEIN 1291
E I LE+ +GLG S+AG D + SIF+ I P G AA DGR+R+ D +L +N
Sbjct: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
Query: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQ-MAVTPFPVPSSSPSSIEDQSGTE 1350
+ +H A +K A S V+L +R + + M + P SI G +
Sbjct: 119 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQ 178
Query: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQ------ 1383
I ++ +DG +++G K L E + AV+ +K
Sbjct: 179 HIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYL 238
Query: 1384 --KYPTKVSFSSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPAT----CPI---- 1430
P+ S P +SY + + Y G P ++ P + P+
Sbjct: 239 KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDL 298
Query: 1431 -----VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQI 1485
+P + I I +G +GLG +IVGG+D I I + G A G L GDQI
Sbjct: 299 LGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQI 356
Query: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENLEIFPVDLQKKAGRGL 1544
L VNGVDLRN+SHE+A AL+ Q V ++ Y+ E + R E + L + G
Sbjct: 357 LSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLM-NSSLGS 415
Query: 1545 GLSIVGKRNGSGVFISDIVKGGAADLDGRLIQ------GDQILSVNGED--------MRN 1590
G + + G +I + G L Q GD + ++ D + +
Sbjct: 416 GTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHS 475
Query: 1591 ASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
S+ + + + + E RL+A W S S SQG + S S
Sbjct: 476 DSETDDIGFIPSKRRVERREWSRLKAKDWGS----SSGSQGREDSVLS 519
Score = 103 bits (258), Expect = 1e-21
Identities = 96/354 (27%), Positives = 157/354 (44%), Gaps = 68/354 (19%)
Query: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
+ E I +ER ++G LGFS+ + ++G IF+ + PG A +D RL+ ND IL +
Sbjct: 59 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV 117
Query: 189 NHTPLDQNISHQQAIALLQQTTGSLRL-IVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
N + + ++H A+ L++ +RL ++ R+P K V
Sbjct: 118 NEVDV-REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK--------------------VM 156
Query: 248 EVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
E++LI GLGF I GG + + V I+ GG A +DGRLQ GD IL +
Sbjct: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
Query: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI--SVTPP--------------------- 337
++ + E L+N + V + VA+ + S PP
Sbjct: 217 LEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 276
Query: 338 --APAALPVALP----TVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
P A+ P VA G + E + ++ + LG IVG GE
Sbjct: 277 TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRI-VIHRGSTGLGFNIVG----GEDGE 331
Query: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
GI++ I+ G A +G ++ D+I++V+GV+++ ++ L+NAGQ V
Sbjct: 332 --GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 383
Score = 80.1 bits (196), Expect = 2e-14
Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 26/252 (10%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++ + P LG SI GG + + G I++ +++E A K L+ GDKI
Sbjct: 158 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQ 1185
L V+ V L++ H +AV A+KN + VV++ + S + + + +Q+ D +
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268
Query: 1186 EKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD 1245
GT P P + + + + E+ D+P E I + +
Sbjct: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE------------DIPREPRRIVIHRG 316
Query: 1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
GLG ++ G +D IF+ I GPA G +R GD++L +N L SH+ A+
Sbjct: 317 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 1306 IIKTAPSKVKLV 1317
+K A V ++
Sbjct: 375 ALKNAGQTVTII 386
Score = 77.0 bits (188), Expect = 2e-13
Identities = 63/234 (26%), Positives = 108/234 (46%), Gaps = 57/234 (24%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I+V + G A +D RL+ D+ILA+N L+ ++ H+
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE-DVMHED 224
Query: 202 AIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVE----------- 250
A+A L+ T + L VA+ +++ L+D+ P + + + ++
Sbjct: 225 AVAALKNTYDVVYLKVAKP-------SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 277
Query: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
+I+ GS GLGF IVGG+ G+ +
Sbjct: 278 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 337
Query: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
I+ GG AD G L+ GD IL + G +++ + EQ A L+N G +V ++ P
Sbjct: 338 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 391
Score = 68.2 bits (165), Expect = 7e-11
Identities = 41/92 (44%), Positives = 54/92 (58%), Gaps = 11/92 (11%)
Query: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
PR + I R + LG +IVGG E+ +GIFI +L PA + L+ GD+I
Sbjct: 308 PRRIVIHRG-STGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRKGDQI 356
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
L V+GVDL+NASH +A A+KNAG V I Q
Sbjct: 357 LSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Score = 55.5 bits (132), Expect = 5e-07
Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 2/79 (2%)
Query: 1687 LGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVV 1744
LG SIAGG G+ GD +++ I G A + +L++GD+I+++N L+ + H D V
Sbjct: 167 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226
Query: 1745 NLLKNAYGRIILQVVADTN 1763
LKN Y + L+V +N
Sbjct: 227 AALKNTYDVVYLKVAKPSN 245
Score = 53.5 bits (127), Expect = 2e-06
Identities = 65/258 (25%), Positives = 98/258 (37%), Gaps = 58/258 (22%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE----------- 626
D Y++ I+ GG G LQ D++L VN + L +AV+ LK
Sbjct: 183 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 242
Query: 627 ----------VPPPFTLVCCRRLFDDEAS------VDEPRRTETSLPETEVDHNMDVNTE 670
PP T + L D+E S D P + P D+ E
Sbjct: 243 PSNAYLSDSYAPPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE 301
Query: 671 EDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGG 730
ED E + + + + GLGF+I+ +D I I ++A G A+ SG
Sbjct: 302 ED-------IPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGE 349
Query: 731 LLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSN 790
L GD+++SVN L N S +A LK N ++ I+
Sbjct: 350 LRKGDQILSVNGVDLRNASHEQAAIALK------------------NAGQTVTIIAQYKP 391
Query: 791 EDKTEFSGTIHDINSSLI 808
E+ + F IHD+ L+
Sbjct: 392 EEYSRFEAKIHDLREQLM 409
Score = 51.2 bits (121), Expect = 9e-06
Identities = 47/147 (31%), Positives = 70/147 (47%), Gaps = 20/147 (13%)
Query: 1008 RREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEG-EGEETPNFSHWGPP 1066
R + ED P +H + ++A++ +++ TDT E P G EGE
Sbjct: 13 RYQDEDTPPLEHSPAHLPNQANSPPVIVN----TDTLEAPGYVNGTEGEM---------- 58
Query: 1067 RIVEIFREP-NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
EI E N LG SI GG G++ IFI +++ A + L+ D I
Sbjct: 59 EYEEITLERGNSGLGFSIAGGTD---NPHIGDD-PSIFITKIIPGGAAAQDGRLRVNDSI 114
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
L V+ VD++ +HS AVEA+K AG+ V
Sbjct: 115 LFVNEVDVREVTHSAAVEALKEAGSIV 141
Score = 45.8 bits (107), Expect = 4e-04
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L+ D +L VN + + + AV LKE L RR
Sbjct: 92 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-- 149
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
P E +V ++L+K KGLGFSI
Sbjct: 150 ---------------PPAE----------------------KVMEIKLIKGPKGLGFSIA 172
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I + ++ G A + G L GD++++VN L++ +AV LK
Sbjct: 173 GGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 232
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 233 -YDVVYLKVAKP 243
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 6/92 (6%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
R+ I I R STG LGF++V IF+ + G AD L++ DQIL++N
Sbjct: 306 REPRRIVIHRGSTG-LGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVN 360
Query: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
L +N SH+QA L+ ++ +I +P
Sbjct: 361 GVDL-RNASHEQAAIALKNAGQTVTIIAQYKP 391
Score = 32.7 bits (73), Expect = 3.3
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + + L + GLGFSI D P I I ++ G A + G L D ++ VN
Sbjct: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
Query: 742 EYCLDNTSLAEAVEILK 758
E + + + AVE LK
Sbjct: 119 EVDVREVTHSAAVEALK 135
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 132 bits (331), Expect = 4e-30
Identities = 108/351 (30%), Positives = 156/351 (44%), Gaps = 49/351 (13%)
Query: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
I + +G SGLG SI GG D P I I ++ GAAA DGRL D IL VN VD+
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK-- 1551
SH +A+ AL++ VRL V R +++F K +GLG SI G
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLF------KGPKGLGFSIAGGVG 161
Query: 1552 ----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
+ ++++ I+ GGAA DGRL GD++L VN + + E ILK +V
Sbjct: 162 NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 221
Query: 1608 QLEIGRLRAGSWT----------SARTTSQNSQGSQQSAHSSCHPSFAPVITG------- 1650
L++G+ T S +N S + S P+ G
Sbjct: 222 YLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK 281
Query: 1651 -----------LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL 1699
Q+ T++ S Q+ + EPR V +++ S LG +I GG
Sbjct: 282 HMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE- 339
Query: 1700 GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
+F++ I A G A + +L+ GD+I+S+NG L G SH LK A
Sbjct: 340 ---GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
Score = 122 bits (306), Expect = 3e-27
Identities = 105/404 (25%), Positives = 174/404 (43%), Gaps = 71/404 (17%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + G+ + I+PGG A DGRL+ D IL++
Sbjct: 46 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V ++ + + L+ G+ VR+ V R P + + L KGP
Sbjct: 106 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 149
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G VG H + IYV II G AA +G +QV D+++
Sbjct: 150 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
V+ +++ + + V +L+N +VV+L + + T T P PP + P++ L
Sbjct: 196 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 255
Query: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENL 534
G +E +T++ G I + + L +D+ + + P
Sbjct: 256 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTSHSQHSTATRQPS---------- 303
Query: 535 LGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGG 590
TL ++ + E +K + +H G+ + G ++S I++GG
Sbjct: 304 ---------MTLQRAVSLEGEPRK----VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGG 350
Query: 591 PVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
P D G LQ D++L VNG+ L G S +A + LK T++
Sbjct: 351 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
Score = 107 bits (266), Expect = 1e-22
Identities = 104/384 (27%), Positives = 166/384 (43%), Gaps = 97/384 (25%)
Query: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182
G +IEY I +ER ++G LGFS+ + ++G IF+ + PG A D RL+ N
Sbjct: 38 GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 96
Query: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242
D IL +N + + +SH +A+ L++ +RL V R + ETV
Sbjct: 97 DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 141
Query: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295
E++L GLGF I GG + + V I+ GG A +DGRLQ GD +L
Sbjct: 142 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 196
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT----PPAPAAL-- 342
+ +++ +T E+ +L+N V + V + DP G +T PP L
Sbjct: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 256
Query: 343 --------PVALPTVASKGPGSDSSLFETYNVE--------------------------- 367
+LP ++ PG S + + V+
Sbjct: 257 GNNGTLEYKTSLPPIS---PGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLE 313
Query: 368 ------LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAV 421
++ K LG IVG GE GI+V I+ G A +G +Q D+I++V
Sbjct: 314 GEPRKVVLHKGSTGLGFNIVG----GEDGE--GIFVSFILAGGPADLSGELQRGDQILSV 367
Query: 422 DGVNIQGFANHDVVEVLRNAGQVV 445
+G++++G ++ L+ AGQ V
Sbjct: 368 NGIDLRGASHEQAAAALKGAGQTV 391
Score = 99.4 bits (246), Expect = 3e-20
Identities = 83/298 (27%), Positives = 132/298 (44%), Gaps = 39/298 (13%)
Query: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
I+L K GLG S+AG + SI+V I G A DGR+++GD LL +NN L
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
Query: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
+H+ A AI+K ++V+++ P+ P + S + S
Sbjct: 203 EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENH--LLSG 257
Query: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
+G++E +K ++ + +Y +P + D D+T +
Sbjct: 258 NNGTLE-----------YKTSLPPISPGRY-------------SPIPKHMLVDDDYTSHS 293
Query: 1416 GFQAPLSVDPATCP---IVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGA 1472
T + G+ + + KG +GLG +IVGG+D I + + G
Sbjct: 294 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG--EGIFVSFILAGGP 351
Query: 1473 AARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENL 1529
A G L GDQIL VNG+DLR +SHE+A AL+ Q V ++ Y+ E + R E +
Sbjct: 352 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKI 409
Score = 90.9 bits (224), Expect = 1e-17
Identities = 70/262 (26%), Positives = 112/262 (42%), Gaps = 23/262 (8%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++F+ P LG SI GG + + G I++ ++++ A K L+ GD++
Sbjct: 143 IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
Query: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177
L V+ L+ +H EAV +KN G P + P + +
Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 254
Query: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQ--KIRQRYADLPG 1235
+ N T E K +P P + + DD + + T Q QR L G
Sbjct: 255 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEG 314
Query: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
E + L K GLG ++ G +D IFV I GPA G ++ GD++L +N L
Sbjct: 315 EPRKVVLHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDL 372
Query: 1296 YGRSHQNASAIIKTAPSKVKLV 1317
G SH+ A+A +K A V ++
Sbjct: 373 RGASHEQAAAALKGAGQTVTII 394
Score = 78.6 bits (192), Expect = 5e-14
Identities = 66/250 (26%), Positives = 107/250 (42%), Gaps = 66/250 (26%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I+V + G A +D RL+ D++L +N+ L++ ++H++
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE-VTHEE 209
Query: 202 AIA-----------------------------------------LLQQTTGSLRLIVARE 220
A+A LL G+L +
Sbjct: 210 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 269
Query: 221 PV--------------------HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLG 259
P+ H++ ST++ TL V G +V L +GLG
Sbjct: 270 PISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLG 329
Query: 260 FGIVGGKTS-GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGN 318
F IVGG+ G+ V I+ GG AD G LQ GD IL + G +++G + EQ A L+ G
Sbjct: 330 FNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 389
Query: 319 SVRMLVARDP 328
+V ++ P
Sbjct: 390 TVTIIAQYQP 399
Score = 74.3 bits (181), Expect = 1e-12
Identities = 76/276 (27%), Positives = 113/276 (40%), Gaps = 72/276 (26%)
Query: 1500 EAITALRQTPQKVR---LVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGS- 1555
+ I +L+Q Q ++ + V E Y EE + L++ GLG SI G +
Sbjct: 17 DTIASLKQCEQAMQHAFIPVNGTEIEYEFEE------ITLER-GNSGLGFSIAGGTDNPH 69
Query: 1556 -----GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLE 1610
G+FI+ I+ GGAA DGRL D IL VN D+ S LK A +V+L
Sbjct: 70 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 129
Query: 1611 IGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGT 1670
+ R R P+ L+ +V K P
Sbjct: 130 VRRRR------------------------------PI---LETVVEIKLFKGPK------ 150
Query: 1671 DMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIV 1728
LG SIAGG G+ GD +++ I G A + +L+VGDR++
Sbjct: 151 ---------------GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
Query: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
+N L+ ++H + V +LKN + L+V T I
Sbjct: 196 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 231
Score = 64.7 bits (156), Expect = 8e-10
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)
Query: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
G PR V + + + LG +IVGG E+ +GIF+ +L PA + L+ GD
Sbjct: 314 GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 362
Query: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
+IL V+G+DL+ ASH +A A+K AG V I Q
Sbjct: 363 QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
Score = 62.4 bits (150), Expect = 4e-09
Identities = 38/98 (38%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
P E ++EI KG GLG SI GG N+I + ++ + GAA +DGRL GD++
Sbjct: 135 PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
Query: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHY 1523
L VN L +HEEA+ L+ T + V L V + Y
Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIY 232
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/192 (28%), Positives = 80/192 (41%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L+ D +L VN + + S +AV LKE L RR
Sbjct: 77 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR--- 133
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
+ ET V+ ++L K KGLGFSI
Sbjct: 134 ------------RPILETVVE------------------------IKLFKGPKGLGFSIA 157
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I + ++ G A++ G L GDRL+ VN Y L+ + EAV ILK
Sbjct: 158 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 217
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 218 SE-VVYLKVGKP 228
Score = 50.1 bits (118), Expect = 2e-05
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
N LG SI GG G++ GIFI +++ A + L+ D IL V+ VD+
Sbjct: 54 NSGLGFSIAGGTD---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109
Query: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
SHS+AVEA+K AG+ V V+
Sbjct: 110 VSHSKAVEALKEAGSIVRLYVR 131
Score = 43.9 bits (102), Expect = 0.001
Identities = 66/273 (24%), Positives = 99/273 (36%), Gaps = 65/273 (23%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK--------EVPP 629
D Y++ I+ GG G LQ D LL VN L + EAV+ LK +V
Sbjct: 168 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 227
Query: 630 PFTLVCCRRLF--DDEASVDEPRRT------------ETSLPE------TEVDHNMDVNT 669
P T+ D S P +TSLP + + +M V+
Sbjct: 228 PTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD 287
Query: 670 EEDDDGE--LALWSPEVKI------------VELVKDCKGLGFSILDYQDPLDPTRSVIV 715
+ + A P + + V L K GLGF+I+ +D I
Sbjct: 288 DYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIF 342
Query: 716 IRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVE 775
+ ++A G A+ SG L GD+++SVN L S +A LK
Sbjct: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--------------- 387
Query: 776 DNEEESCYILHSSSNEDKTEFSGTIHDINSSLI 808
++ I+ ED F IHD+ ++
Sbjct: 388 ---GQTVTIIAQYQPEDYARFEAKIHDLREQMM 417
Score = 34.3 bits (77), Expect = 1.1
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + + L + GLGFSI D P I I ++ G A G L D ++ VN
Sbjct: 44 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
Query: 742 EYCLDNTSLAEAVEILK 758
E + S ++AVE LK
Sbjct: 104 EVDVSEVSHSKAVEALK 120
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 122 bits (305), Expect = 4e-27
Identities = 107/339 (31%), Positives = 158/339 (46%), Gaps = 35/339 (10%)
Query: 1434 QEMIIEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
+E+++E +G SGLG SI GG D P I I ++ GAAA DGRL D +L VN
Sbjct: 130 EEIVLE--RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 1490 GVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIV 1549
VD+ H A+ AL++ VRLVV R R I V+L K +GLG SI
Sbjct: 188 EVDVSEVVHSRAVEALKEAGPVVRLVVRR-----RQPPPETIMEVNLLK-GPKGLGFSIA 241
Query: 1550 GKRNG------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
G + ++I+ I++GGAA DGRL GD++L+VN ++++ E LK
Sbjct: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
Query: 1604 QGLVQLEIGR---------LRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNL 1654
+V L++ + + S T ++ S S+ + V
Sbjct: 302 SDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQ 361
Query: 1655 VGTKRVSD-PSQKNSGTDM--EPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQA 1711
V R S P + D EPR + +++ S LG +I GG +F++ I A
Sbjct: 362 VPPTRYSPIPRHMLAEEDFTREPRKIILHKG-STGLGFNIVGGEDGE----GIFVSFILA 416
Query: 1712 SGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
G A + +L+ GDRI+S+NG L +H LK A
Sbjct: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
Score = 106 bits (264), Expect = 2e-22
Identities = 96/364 (26%), Positives = 152/364 (41%), Gaps = 85/364 (23%)
Query: 133 EYIDIERPSTGGLGFSVVALRSQNLGKVD---------IFVKDVQPGSVADRDQRLKEND 183
E I +ER ++G LGFS+ G +D IF+ + PG A D RL ND
Sbjct: 130 EEIVLERGNSG-LGFSIA-------GGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181
Query: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCW 243
+L +N + + + H +A+ L++ +RL+V R PET+
Sbjct: 182 CVLRVNEVDVSE-VVHSRAVEALKEAGPVVRLVVRRR--------------QPPPETIM- 225
Query: 244 GHVEEVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKI 296
EV L+ GLGF I GG + + + I+ GG A +DGRLQ GD +L +
Sbjct: 226 ----EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
Query: 297 GGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----------------------------- 327
TN+Q + E+ L+N + V + VA+
Sbjct: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHN 341
Query: 328 ------PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIV 381
A + V+ PAP +P + + ++ ++ K LG IV
Sbjct: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIV 401
Query: 382 GYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNA 441
G GE GI+V I+ G A +G ++ D+I++V+GVN++ + L+ A
Sbjct: 402 G----GEDGE--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
Query: 442 GQVV 445
GQ V
Sbjct: 456 GQSV 459
Score = 100 bits (249), Expect = 1e-20
Identities = 98/348 (28%), Positives = 149/348 (42%), Gaps = 60/348 (17%)
Query: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
I LE+ +GLG S+AG D + IF+ I P G AA DGR+ + D +L +N +
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQ-MAVTPFPVPSSSPSSIEDQSGTEPI-- 1352
H A +K A V+LV R + M V P SI G + I
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPG 251
Query: 1353 -------------SSEEDGSVEVGIKQLPESES------FKLAVSQMKQQK--------Y 1385
++++DG +++G + L + + + AV+ +K
Sbjct: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Query: 1386 PTKVSFSSQEIPLAPASSY------HSTDADFTGYGG-------FQAPLSVDPATCPIVP 1432
P + + P AS++ H + GY G + AP V P +P
Sbjct: 312 PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371
Query: 1433 GQEMIIE----------ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAG 1482
+ E + KG +GLG +IVGG+D I + + G A G L G
Sbjct: 372 RHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG--EGIFVSFILAGGPADLSGELRRG 429
Query: 1483 DQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENL 1529
D+IL VNGV+LRN++HE+A AL++ Q V +V YR E + R E +
Sbjct: 430 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
Score = 97.1 bits (240), Expect = 1e-19
Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 37/230 (16%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + G+ + I+PGG A DGRL D +L++
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V + + + L+ G VR++V R PP + V L KGP
Sbjct: 190 DVSEVVHSRAVEALKEAGPVVRLVVRRRQ-------PPPETIMEVNL----LKGP----- 233
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G +G H + IY+ II G AA +G +Q+ D+++
Sbjct: 234 --------------KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
AV+ N+Q + + V L+N +V+L + + + PP T
Sbjct: 280 AVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYAST 329
Score = 89.0 bits (219), Expect = 4e-17
Identities = 70/234 (29%), Positives = 113/234 (48%), Gaps = 50/234 (21%)
Query: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
GLGFS+ + +Q++ G I++ + G A +D RL+ D++LA+N+T L Q++ H++
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL-QDVRHEE 293
Query: 202 AIALLQQTTGSLRLIVARE-PVHTK--------SSTSSSLNDTTLPETVCWGHVEEVE-- 250
A+A L+ T+ + L VA+ +H +ST ++L D + G++ VE
Sbjct: 294 AVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
Query: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
+++ GS GLGF IVGG+ G+ V
Sbjct: 354 VSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSF 413
Query: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
I+ GG AD G L+ GD IL + G N++ T EQ A L+ G SV ++ P
Sbjct: 414 ILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP 467
Score = 76.6 bits (187), Expect = 2e-13
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 37/261 (14%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
V + + P LG SI GG + + G I+I +++E A K L+ GD++
Sbjct: 227 VNLLKGPK-GLGFSIAGGI-------GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ---SLSSTPRVIPNVHNKA------NKI 1176
L V+ +LQ+ H EAV ++KN + V V SL P + N I
Sbjct: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHI 338
Query: 1177 TGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGE 1236
+ N + E + PP P Y + E D E
Sbjct: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE---------------DFTRE 383
Query: 1237 LHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
I L K GLG ++ G +D IFV I GPA G +R GD +L +N L
Sbjct: 384 PRKIILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 1297 GRSHQNASAIIKTAPSKVKLV 1317
+H+ A+A +K A V +V
Sbjct: 442 NATHEQAAAALKRAGQSVTIV 462
Score = 73.6 bits (179), Expect = 2e-12
Identities = 97/403 (24%), Positives = 152/403 (37%), Gaps = 113/403 (28%)
Query: 328 PAG-DISVTPPAPAALPVALPTVASKGPG-------SDSSLFETYN--------VELVRK 371
P G D+ PP P + P + GP ++ +E N E+V +
Sbjct: 77 PTGRDVGPVPPKPVP-GKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLE 135
Query: 372 DGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFA 430
G S LG I G + H + GI++ IIPG AA +G + VND ++ V+ V++
Sbjct: 136 RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVV 195
Query: 431 NHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPP------------- 477
+ VE L+ AG VV L + RR +PP + V LK P
Sbjct: 196 HSRAVEALKEAGPVVRLVVRRR---------QPPPETIMEVNLLKGPKGLGFSIAGGIGN 246
Query: 478 -------ALFLTGAVE-----------------TETNVDGEDEEIKERIDTLKNDNIQAL 513
++++T +E N + +D +E + +LKN +
Sbjct: 247 QHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVY 306
Query: 514 EKLEKVPDSPENELKSRWENLLGPDY-EVMVATLDTQIADDAEL---------------- 556
K+ K N++ + PDY A D I+ ++ L
Sbjct: 307 LKVAKPGSLHLNDMYA------PPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPP 360
Query: 557 ----QKYSKLLPIHTLR-------------------LGVE-VDSFDGHH-YISSIVSGGP 591
+YS +P H L LG V DG ++S I++GGP
Sbjct: 361 QVPPTRYSP-IPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 419
Query: 592 VDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
D G L+ D +L VNG+ L + +A + LK T+V
Sbjct: 420 ADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Score = 62.8 bits (151), Expect = 3e-09
Identities = 33/87 (37%), Positives = 50/87 (57%), Gaps = 10/87 (11%)
Query: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130
I + + LG +IVGG E+ +GIF+ +L PA + L+ GD+IL V+G
Sbjct: 388 ILHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELRRGDRILSVNG 437
Query: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
V+L+NA+H +A A+K AG V + Q
Sbjct: 438 VNLRNATHEQAAAALKRAGQSVTIVAQ 464
Score = 62.0 bits (149), Expect = 5e-09
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 62/229 (27%)
Query: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
++ GLG SI G + G+FI+ I+ GGAA +DGRL D +L VN D+
Sbjct: 135 ERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEV 194
Query: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
LK A PV+
Sbjct: 195 VHSRAVEALKEA-----------------------------------------GPVV--- 210
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
LV +R P T ME ++ + LG SIAGG G+ GD ++I I
Sbjct: 211 -RLVVRRRQPPPE-----TIMEVNLLKGPK----GLGFSIAGGIGNQHIPGDNSIYITKI 260
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
G A + +L++GDR++++N L + H + V LKN + L+V
Sbjct: 261 IEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
Score = 56.6 bits (135), Expect = 2e-07
Identities = 61/257 (23%), Positives = 98/257 (38%), Gaps = 49/257 (19%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D YI+ I+ GG G LQ D LL VN L EAV+ LK L +
Sbjct: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Query: 638 ---RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSP------------ 682
+D + + T T+L + + HN + + +++ +P
Sbjct: 312 PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371
Query: 683 -----------EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGL 731
E + + L K GLGF+I+ +D I + ++A G A+ SG L
Sbjct: 372 RHMLAEEDFTREPRKIILHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGEL 426
Query: 732 LPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNE 791
GDR++SVN L N + +A LK + + +P E
Sbjct: 427 RRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP------------------E 468
Query: 792 DKTEFSGTIHDINSSLI 808
+ + F IHD+ ++
Sbjct: 469 EYSRFESKIHDLREQMM 485
Score = 52.0 bits (123), Expect = 5e-06
Identities = 57/192 (29%), Positives = 79/192 (41%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L D +L VN + + AV LKE P LV RR
Sbjct: 161 FITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRR--- 217
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
+P PET ++ V L+K KGLGFSI
Sbjct: 218 ------QPP------PETIME------------------------VNLLKGPKGLGFSIA 241
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I I ++ G A++ G L GDRL++VN L + EAV LK
Sbjct: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 302 -SDMVYLKVAKP 312
Score = 48.5 bits (114), Expect = 6e-05
Identities = 33/102 (32%), Positives = 46/102 (45%), Gaps = 8/102 (7%)
Query: 1071 IFREPNVSLGISIVGGQTVIKRLKNGE--ELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
+ N LG SI GG + N + GIFI +++ A L D +L V
Sbjct: 133 VLERGNSGLGFSIAGG------IDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVH 1170
+ VD+ HS AVEA+K AG V +V+ P I V+
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVN 228
Score = 33.1 bits (74), Expect = 2.5
Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 687 VELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
+ L + GLGFSI D P P I I ++ G A G L D ++ VNE +
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 746 DNTSLAEAVEILKAVPP 762
+ AVE LK P
Sbjct: 192 SEVVHSRAVEALKEAGP 208
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 120 bits (300), Expect = 2e-26
Identities = 114/437 (26%), Positives = 185/437 (42%), Gaps = 85/437 (19%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + G+ + I+PGG A DGRL+ D IL++
Sbjct: 202 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V ++ + + L+ G+ VR+ V R P + + L KGP
Sbjct: 262 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 305
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G VG H + IYV II G AA +G +QV D+++
Sbjct: 306 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 351
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
V+ +++ + + V +L+N +VV+L + + T T P PP + P++ L
Sbjct: 352 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 411
Query: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDN--------IQALEKLEKVPDSPENE 526
G +E +T++ G I + + L +D+ + KL P SP +
Sbjct: 412 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTRPPEPVYSTVNKLCDKPASPRHY 469
Query: 527 LK-------------SRWENLLGPDYEVM------------VATLDTQIADDAELQKYSK 561
S + L PD E+ TL ++ + E +K
Sbjct: 470 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK--- 526
Query: 562 LLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSR 617
+ +H G+ + G ++S I++GGP D G LQ D++L VNG+ L G S
Sbjct: 527 -VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 585
Query: 618 REAVSFLKEVPPPFTLV 634
+A + LK T++
Sbjct: 586 EQAAAALKGAGQTVTII 602
Score = 108 bits (271), Expect = 4e-23
Identities = 77/220 (35%), Positives = 106/220 (48%), Gaps = 31/220 (14%)
Query: 1419 APLSVDPA----------TCPIVPGQEMIIE-----ISKGRSGLGLSIVGGKDTPL---- 1459
+PL PA T P V G E+ E + +G SGLG SI GG D P
Sbjct: 170 SPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDD 229
Query: 1460 NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
I I ++ GAAA DGRL D IL VN VD+ SH +A+ AL++ VRL V R
Sbjct: 230 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 289
Query: 1520 EAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK------RNGSGVFISDIVKGGAADLDGR 1573
+++F K +GLG SI G + ++++ I+ GGAA DGR
Sbjct: 290 RPILETVVEIKLF------KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 343
Query: 1574 LIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
L GD++L VN + + E ILK +V L++G+
Sbjct: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 103 bits (258), Expect = 1e-21
Identities = 117/412 (28%), Positives = 169/412 (41%), Gaps = 60/412 (14%)
Query: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEIN 1291
E I LE+ +GLG S+AG D + IF+ I P G AA DGR+R+ D +L +N
Sbjct: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
Query: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQSGTE 1350
+ SH A +K A S V+L R + + + F P SI G +
Sbjct: 260 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 319
Query: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQKY---- 1385
I ++++DG ++VG + L E + + AV+ +K
Sbjct: 320 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 379
Query: 1386 ----PTKVSFSSQEIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQ----- 1434
PT + + P P HS + G L + PI PG+
Sbjct: 380 KVGKPTTIYMTD---PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 436
Query: 1435 -EMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV-D 1492
M+++ R + K A H Y + L A + + D
Sbjct: 437 KHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH--YSPVECDKSFLLSAPYSHYHLGLLPD 494
Query: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQ-KKAGRGLGLSIVGK 1551
+SH + TA RQ ++ V +LE P + K GLG +IVG
Sbjct: 495 SEMTSHSQHSTATRQPSMTLQRAV-----------SLEGEPRKVVLHKGSTGLGFNIVGG 543
Query: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
+G G+F+S I+ GG ADL G L +GDQILSVNG D+R AS E A LK A
Sbjct: 544 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
Score = 99.0 bits (245), Expect = 4e-20
Identities = 93/325 (28%), Positives = 141/325 (43%), Gaps = 41/325 (12%)
Query: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
I+L K GLG S+AG + SI+V I G A DGR+++GD LL +NN L
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
Query: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP---------------SSSP 1340
+H+ A AI+K ++V+++ P+ P S +
Sbjct: 359 EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415
Query: 1341 SSIEDQSGTEPISSEEDGS------VEVGIKQLPE---SESFKLAVSQMKQQKYPTKVSF 1391
++E ++ PIS V+ + PE S KL + Y + V
Sbjct: 416 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY-SPVEC 474
Query: 1392 SSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPATCP---IVPGQEMIIEISKGRS 1445
+ AP S YH D++ T + T + G+ + + KG +
Sbjct: 475 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 534
Query: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
GLG +IVGG+D I + + G A G L GDQIL VNG+DLR +SHE+A AL
Sbjct: 535 GLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 592
Query: 1506 RQTPQKVRLVV-YRDEAHYRDEENL 1529
+ Q V ++ Y+ E + R E +
Sbjct: 593 KGAGQTVTIIAQYQPEDYARFEAKI 617
Score = 88.2 bits (217), Expect = 7e-17
Identities = 69/227 (30%), Positives = 108/227 (47%), Gaps = 41/227 (18%)
Query: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182
G +IEY I +ER ++G LGFS+ + ++G IF+ + PG A D RL+ N
Sbjct: 194 GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 252
Query: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242
D IL +N + + +SH +A+ L++ +RL V R + ETV
Sbjct: 253 DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 297
Query: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295
E++L GLGF I GG + + V I+ GG A +DGRLQ GD +L
Sbjct: 298 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 352
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT 335
+ +++ +T E+ +L+N V + V + DP G +T
Sbjct: 353 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDIT 399
Score = 84.7 bits (208), Expect = 7e-16
Identities = 85/331 (25%), Positives = 139/331 (41%), Gaps = 38/331 (11%)
Query: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
P E ++EI KG GLG SI GG N+I + ++ + GAA +DGRL GD++
Sbjct: 291 PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
Query: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLG 1545
L VN L +HEEA+ L+ T + V L V + Y + P D+ +
Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDP---YGPPDITHSYSPPME 407
Query: 1546 LSIVGKRNGSGVF---ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
++ NG+ + + I G + + ++ D D + +T+ K
Sbjct: 408 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD--------DYTRPPEPVYSTVNKL 459
Query: 1603 AQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP---VITGLQNLVGTKR 1659
+ S + + +S H P + + Q+ T++
Sbjct: 460 CD----------KPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 509
Query: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
S Q+ + EPR V +++ S LG +I GG +F++ I A G A +
Sbjct: 510 PSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE----GIFVSFILAGGPADLSG 564
Query: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
+L+ GD+I+S+NG L G SH LK A
Sbjct: 565 ELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
Score = 73.2 bits (178), Expect = 2e-12
Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 62/235 (26%)
Query: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
++ GLG SI G + G+FI+ I+ GGAA DGRL D IL VN D+
Sbjct: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266
Query: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
S LK A +V+L + R R P+ L
Sbjct: 267 SHSKAVEALKEAGSIVRLYVRRRR------------------------------PI---L 293
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
+ +V K P LG SIAGG G+ GD +++ I
Sbjct: 294 ETVVEIKLFKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 332
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
G A + +L+VGDR++ +N L+ ++H + V +LKN + L+V T I
Sbjct: 333 IDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 387
Score = 68.2 bits (165), Expect = 7e-11
Identities = 40/108 (37%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 223 HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGL 280
H++ ST++ TL V G +V L +GLGF IVGG+ G+ V I+ GG
Sbjct: 500 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 559
Query: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
AD G LQ GD IL + G +++G + EQ A L+ G +V ++ P
Sbjct: 560 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 607
Score = 64.7 bits (156), Expect = 8e-10
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)
Query: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
G PR V + + + LG +IVGG E+ +GIF+ +L PA + L+ GD
Sbjct: 522 GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 570
Query: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
+IL V+G+DL+ ASH +A A+K AG V I Q
Sbjct: 571 QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 604
Score = 62.4 bits (150), Expect = 4e-09
Identities = 36/122 (29%), Positives = 62/122 (50%)
Query: 332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
IS +PA + V T+ + + + + + + + LG I G H G+
Sbjct: 169 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 228
Query: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
GI++ IIPG AA +G ++VND I+ V+ V++ ++ VE L+ AG +V L + R
Sbjct: 229 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 288
Query: 452 RK 453
R+
Sbjct: 289 RR 290
Score = 55.8 bits (133), Expect = 4e-07
Identities = 68/315 (21%), Positives = 111/315 (35%), Gaps = 77/315 (24%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++F+ P LG SI GG + + G I++ ++++ A K L+ GD++
Sbjct: 299 IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
Query: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177
L V+ L+ +H EAV +KN G P + P + +
Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 410
Query: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
+ N T E K +P P + + DD E T K+ + A P
Sbjct: 411 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS-PRHY 469
Query: 1238 HIIELEKD---------------------------------------------------- 1245
+E +K
Sbjct: 470 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 529
Query: 1246 -KNGLGL--SLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
K GL ++ G +D IFV I GPA G ++ GD++L +N L G SH+
Sbjct: 530 HKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 587
Query: 1303 ASAIIKTAPSKVKLV 1317
A+A +K A V ++
Sbjct: 588 AAAALKGAGQTVTII 602
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/192 (28%), Positives = 80/192 (41%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L+ D +L VN + + S +AV LKE L RR
Sbjct: 233 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR--- 289
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
+ ET V+ ++L K KGLGFSI
Sbjct: 290 ------------RPILETVVE------------------------IKLFKGPKGLGFSIA 313
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I + ++ G A++ G L GDRL+ VN Y L+ + EAV ILK
Sbjct: 314 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 373
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 374 SE-VVYLKVGKP 384
Score = 53.1 bits (126), Expect = 2e-06
Identities = 45/128 (35%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 1634 QSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDA-LGISIA 1692
QS S S AP+I L D +GT++E EI E ++ LG SIA
Sbjct: 166 QSHISPLKASPAPIIVNTDTL-------DTIPYVNGTEIEYEFEEITLERGNSGLGFSIA 218
Query: 1693 GGRGSP-LGDIP-VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
GG +P +GD P +FI I G AA +L+V D I+ +N + +SH+ V LK A
Sbjct: 219 GGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
Query: 1751 YGRIILQV 1758
+ L V
Sbjct: 279 GSIVRLYV 286
Score = 51.6 bits (122), Expect = 7e-06
Identities = 73/309 (23%), Positives = 124/309 (40%), Gaps = 38/309 (12%)
Query: 852 EMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPL-SHIQEATPVPSVNELHFGT 910
++ EF L + E ++E ++ Q + L P +Q+++ + +
Sbjct: 14 DIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKSSELTDCSGSKENA 73
Query: 911 QWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRF 970
+ N+ ++S E T T Q G CP +N +E+ +P + +
Sbjct: 74 SCIEQNKENQSFENETDETT----TQNQGRCPA----QNCSVEAPAWMPVHHCTKYRYQD 125
Query: 971 DDLENLNSLAKTSLDLGMIPNDVQGPSLL-IDLPVVAQRREQEDLPLYQHQATRVISKAS 1029
+D + +SL + + ++V+GP L+ + ++Q L H + S A
Sbjct: 126 EDAPHDHSLPR-------LTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
Query: 1030 AYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREP-NVSLGISIVGGQT 1088
TDT + G E EI E N LG SI GG
Sbjct: 179 IIVN-------TDTLDTIPYVNGTEIEY---------EFEEITLERGNSGLGFSIAGGTD 222
Query: 1089 VIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA 1148
G++ GIFI +++ A + L+ D IL V+ VD+ SHS+AVEA+K A
Sbjct: 223 ---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
Query: 1149 GNPVVFIVQ 1157
G+ V V+
Sbjct: 279 GSIVRLYVR 287
Score = 38.5 bits (88), Expect = 0.060
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 23/126 (18%)
Query: 683 EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
E + V L K GLGF+I+ +D I + ++A G A+ SG L GD+++SVN
Sbjct: 523 EPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQILSVNG 577
Query: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHD 802
L S +A LK ++ I+ ED F IHD
Sbjct: 578 IDLRGASHEQAAAALKGA------------------GQTVTIIAQYQPEDYARFEAKIHD 619
Query: 803 INSSLI 808
+ ++
Sbjct: 620 LREQMM 625
Score = 38.5 bits (88), Expect = 0.060
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
GLGF++V IFV + G AD L+ DQIL++N L + SH+QA
Sbjct: 535 GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RGASHEQAA 589
Query: 204 ALLQQTTGSLRLIVAREP 221
A L+ ++ +I +P
Sbjct: 590 AALKGAGQTVTIIAQYQP 607
Score = 34.3 bits (77), Expect = 1.1
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + + L + GLGFSI D P I I ++ G A G L D ++ VN
Sbjct: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
Query: 742 EYCLDNTSLAEAVEILK 758
E + S ++AVE LK
Sbjct: 260 EVDVSEVSHSKAVEALK 276
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 120 bits (300), Expect = 2e-26
Identities = 114/437 (26%), Positives = 185/437 (42%), Gaps = 85/437 (19%)
Query: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
EE+ L SGLGF I GG + G+ + I+PGG A DGRL+ D IL++
Sbjct: 97 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156
Query: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
+V ++ + + L+ G+ VR+ V R P + + L KGP
Sbjct: 157 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 200
Query: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
+ LG I G VG H + IYV II G AA +G +QV D+++
Sbjct: 201 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 246
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
V+ +++ + + V +L+N +VV+L + + T T P PP + P++ L
Sbjct: 247 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 306
Query: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDN--------IQALEKLEKVPDSPENE 526
G +E +T++ G I + + L +D+ + KL P SP +
Sbjct: 307 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTRPPEPVYSTVNKLCDKPASPRHY 364
Query: 527 LK-------------SRWENLLGPDYEVM------------VATLDTQIADDAELQKYSK 561
S + L PD E+ TL ++ + E +K
Sbjct: 365 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK--- 421
Query: 562 LLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSR 617
+ +H G+ + G ++S I++GGP D G LQ D++L VNG+ L G S
Sbjct: 422 -VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 480
Query: 618 REAVSFLKEVPPPFTLV 634
+A + LK T++
Sbjct: 481 EQAAAALKGAGQTVTII 497
Score = 108 bits (271), Expect = 4e-23
Identities = 77/220 (35%), Positives = 106/220 (48%), Gaps = 31/220 (14%)
Query: 1419 APLSVDPA----------TCPIVPGQEMIIE-----ISKGRSGLGLSIVGGKDTPL---- 1459
+PL PA T P V G E+ E + +G SGLG SI GG D P
Sbjct: 65 SPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDD 124
Query: 1460 NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
I I ++ GAAA DGRL D IL VN VD+ SH +A+ AL++ VRL V R
Sbjct: 125 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 184
Query: 1520 EAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK------RNGSGVFISDIVKGGAADLDGR 1573
+++F K +GLG SI G + ++++ I+ GGAA DGR
Sbjct: 185 RPILETVVEIKLF------KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 238
Query: 1574 LIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
L GD++L VN + + E ILK +V L++G+
Sbjct: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 103 bits (258), Expect = 1e-21
Identities = 117/412 (28%), Positives = 169/412 (41%), Gaps = 60/412 (14%)
Query: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEIN 1291
E I LE+ +GLG S+AG D + IF+ I P G AA DGR+R+ D +L +N
Sbjct: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
Query: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQSGTE 1350
+ SH A +K A S V+L R + + + F P SI G +
Sbjct: 155 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 214
Query: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQKY---- 1385
I ++++DG ++VG + L E + + AV+ +K
Sbjct: 215 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 274
Query: 1386 ----PTKVSFSSQEIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQ----- 1434
PT + + P P HS + G L + PI PG+
Sbjct: 275 KVGKPTTIYMTD---PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 331
Query: 1435 -EMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV-D 1492
M+++ R + K A H Y + L A + + D
Sbjct: 332 KHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH--YSPVECDKSFLLSAPYSHYHLGLLPD 389
Query: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQ-KKAGRGLGLSIVGK 1551
+SH + TA RQ ++ V +LE P + K GLG +IVG
Sbjct: 390 SEMTSHSQHSTATRQPSMTLQRAV-----------SLEGEPRKVVLHKGSTGLGFNIVGG 438
Query: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
+G G+F+S I+ GG ADL G L +GDQILSVNG D+R AS E A LK A
Sbjct: 439 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
Score = 99.0 bits (245), Expect = 4e-20
Identities = 93/325 (28%), Positives = 141/325 (43%), Gaps = 41/325 (12%)
Query: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
I+L K GLG S+AG + SI+V I G A DGR+++GD LL +NN L
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
Query: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP---------------SSSP 1340
+H+ A AI+K ++V+++ P+ P S +
Sbjct: 254 EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 310
Query: 1341 SSIEDQSGTEPISSEEDGS------VEVGIKQLPE---SESFKLAVSQMKQQKYPTKVSF 1391
++E ++ PIS V+ + PE S KL + Y + V
Sbjct: 311 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY-SPVEC 369
Query: 1392 SSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPATCP---IVPGQEMIIEISKGRS 1445
+ AP S YH D++ T + T + G+ + + KG +
Sbjct: 370 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 429
Query: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
GLG +IVGG+D I + + G A G L GDQIL VNG+DLR +SHE+A AL
Sbjct: 430 GLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 487
Query: 1506 RQTPQKVRLVV-YRDEAHYRDEENL 1529
+ Q V ++ Y+ E + R E +
Sbjct: 488 KGAGQTVTIIAQYQPEDYARFEAKI 512
Score = 88.2 bits (217), Expect = 7e-17
Identities = 69/227 (30%), Positives = 108/227 (47%), Gaps = 41/227 (18%)
Query: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182
G +IEY I +ER ++G LGFS+ + ++G IF+ + PG A D RL+ N
Sbjct: 89 GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 147
Query: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242
D IL +N + + +SH +A+ L++ +RL V R + ETV
Sbjct: 148 DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 192
Query: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295
E++L GLGF I GG + + V I+ GG A +DGRLQ GD +L
Sbjct: 193 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 247
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT 335
+ +++ +T E+ +L+N V + V + DP G +T
Sbjct: 248 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDIT 294
Score = 84.7 bits (208), Expect = 7e-16
Identities = 85/331 (25%), Positives = 139/331 (41%), Gaps = 38/331 (11%)
Query: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
P E ++EI KG GLG SI GG N+I + ++ + GAA +DGRL GD++
Sbjct: 186 PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
Query: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLG 1545
L VN L +HEEA+ L+ T + V L V + Y + P D+ +
Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDP---YGPPDITHSYSPPME 302
Query: 1546 LSIVGKRNGSGVF---ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
++ NG+ + + I G + + ++ D D + +T+ K
Sbjct: 303 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD--------DYTRPPEPVYSTVNKL 354
Query: 1603 AQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP---VITGLQNLVGTKR 1659
+ S + + +S H P + + Q+ T++
Sbjct: 355 CD----------KPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 404
Query: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
S Q+ + EPR V +++ S LG +I GG +F++ I A G A +
Sbjct: 405 PSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE----GIFVSFILAGGPADLSG 459
Query: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
+L+ GD+I+S+NG L G SH LK A
Sbjct: 460 ELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
Score = 73.2 bits (178), Expect = 2e-12
Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 62/235 (26%)
Query: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
++ GLG SI G + G+FI+ I+ GGAA DGRL D IL VN D+
Sbjct: 102 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 161
Query: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
S LK A +V+L + R R P+ L
Sbjct: 162 SHSKAVEALKEAGSIVRLYVRRRR------------------------------PI---L 188
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
+ +V K P LG SIAGG G+ GD +++ I
Sbjct: 189 ETVVEIKLFKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 227
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
G A + +L+VGDR++ +N L+ ++H + V +LKN + L+V T I
Sbjct: 228 IDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 282
Score = 68.2 bits (165), Expect = 7e-11
Identities = 40/108 (37%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 223 HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGL 280
H++ ST++ TL V G +V L +GLGF IVGG+ G+ V I+ GG
Sbjct: 395 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 454
Query: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
AD G LQ GD IL + G +++G + EQ A L+ G +V ++ P
Sbjct: 455 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502
Score = 64.7 bits (156), Expect = 8e-10
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)
Query: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
G PR V + + + LG +IVGG E+ +GIF+ +L PA + L+ GD
Sbjct: 417 GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 465
Query: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
+IL V+G+DL+ ASH +A A+K AG V I Q
Sbjct: 466 QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
Score = 62.4 bits (150), Expect = 4e-09
Identities = 36/122 (29%), Positives = 62/122 (50%)
Query: 332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
IS +PA + V T+ + + + + + + + LG I G H G+
Sbjct: 64 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 123
Query: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
GI++ IIPG AA +G ++VND I+ V+ V++ ++ VE L+ AG +V L + R
Sbjct: 124 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
Query: 452 RK 453
R+
Sbjct: 184 RR 185
Score = 55.8 bits (133), Expect = 4e-07
Identities = 68/315 (21%), Positives = 111/315 (35%), Gaps = 77/315 (24%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
+++F+ P LG SI GG + + G I++ ++++ A K L+ GD++
Sbjct: 194 IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
Query: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177
L V+ L+ +H EAV +KN G P + P + +
Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 305
Query: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
+ N T E K +P P + + DD E T K+ + A P
Sbjct: 306 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS-PRHY 364
Query: 1238 HIIELEKD---------------------------------------------------- 1245
+E +K
Sbjct: 365 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 424
Query: 1246 -KNGLGL--SLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
K GL ++ G +D IFV I GPA G ++ GD++L +N L G SH+
Sbjct: 425 HKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 482
Query: 1303 ASAIIKTAPSKVKLV 1317
A+A +K A V ++
Sbjct: 483 AAAALKGAGQTVTII 497
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/192 (28%), Positives = 80/192 (41%), Gaps = 41/192 (21%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+I+ I+ GG G L+ D +L VN + + S +AV LKE L RR
Sbjct: 128 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR--- 184
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
+ ET V+ ++L K KGLGFSI
Sbjct: 185 ------------RPILETVVE------------------------IKLFKGPKGLGFSIA 208
Query: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
+ P + I + ++ G A++ G L GDRL+ VN Y L+ + EAV ILK
Sbjct: 209 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 268
Query: 761 PPGLVHLGICKP 772
+V+L + KP
Sbjct: 269 SE-VVYLKVGKP 279
Score = 53.1 bits (126), Expect = 2e-06
Identities = 45/128 (35%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 1634 QSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDA-LGISIA 1692
QS S S AP+I L D +GT++E EI E ++ LG SIA
Sbjct: 61 QSHISPLKASPAPIIVNTDTL-------DTIPYVNGTEIEYEFEEITLERGNSGLGFSIA 113
Query: 1693 GGRGSP-LGDIP-VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
GG +P +GD P +FI I G AA +L+V D I+ +N + +SH+ V LK A
Sbjct: 114 GGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173
Query: 1751 YGRIILQV 1758
+ L V
Sbjct: 174 GSIVRLYV 181
Score = 50.1 bits (118), Expect = 2e-05
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
N LG SI GG G++ GIFI +++ A + L+ D IL V+ VD+
Sbjct: 105 NSGLGFSIAGGTD---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 160
Query: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
SHS+AVEA+K AG+ V V+
Sbjct: 161 VSHSKAVEALKEAGSIVRLYVR 182
Score = 38.5 bits (88), Expect = 0.060
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 23/126 (18%)
Query: 683 EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
E + V L K GLGF+I+ +D I + ++A G A+ SG L GD+++SVN
Sbjct: 418 EPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQILSVNG 472
Query: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHD 802
L S +A LK ++ I+ ED F IHD
Sbjct: 473 IDLRGASHEQAAAALKGA------------------GQTVTIIAQYQPEDYARFEAKIHD 514
Query: 803 INSSLI 808
+ ++
Sbjct: 515 LREQMM 520
Score = 38.5 bits (88), Expect = 0.060
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
GLGF++V IFV + G AD L+ DQIL++N L + SH+QA
Sbjct: 430 GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RGASHEQAA 484
Query: 204 ALLQQTTGSLRLIVAREP 221
A L+ ++ +I +P
Sbjct: 485 AALKGAGQTVTIIAQYQP 502
Score = 34.3 bits (77), Expect = 1.1
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E + + L + GLGFSI D P I I ++ G A G L D ++ VN
Sbjct: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
Query: 742 EYCLDNTSLAEAVEILK 758
E + S ++AVE LK
Sbjct: 155 EVDVSEVSHSKAVEALK 171
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 119 bits (297), Expect = 3e-26
Identities = 127/484 (26%), Positives = 205/484 (42%), Gaps = 106/484 (21%)
Query: 1235 GELHIIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINN 1292
G + +EL K+ +GLG+ ++G + RS +I V + G A DGR+ +GDELL IN
Sbjct: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
Query: 1293 QILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQS---- 1347
+L G SH+ A AI+++A V+LV E++ + +T +P + SS+ED S
Sbjct: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-SSVEDVSSWTD 448
Query: 1348 -----------------------GTEP-------------ISSEEDGSVEV--------G 1363
GT+ + S + GS ++ G
Sbjct: 449 NEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG 508
Query: 1364 IKQLPESESF-KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLS 1422
+ +L E + +L V + +VS ++ L S ++ LS
Sbjct: 509 VHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568
Query: 1423 VDPATCP---IVPGQEMIIEISKGRS-GLGLSIVGGKDTPLN--AIVIHEVYEEGAAARD 1476
P I P II + K + GLG SI GG+D I + ++ G+AA D
Sbjct: 569 TTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAED 628
Query: 1477 GRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE---------------- 1520
GRL GD+IL+VNG+ ++ + +EAI +Q + ++ R +
Sbjct: 629 GRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMS 688
Query: 1521 --------------AHYRDE-------------ENLEIFPVDLQKKAGRGLGLS---IVG 1550
A DE ++ + V L K+ GLG+ +
Sbjct: 689 RSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLAL 748
Query: 1551 KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL-KCAQGLVQL 1609
+ + G++I + G A ++ L +GDQIL VN ++R+A+ V IL KC G V+L
Sbjct: 749 ENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 808
Query: 1610 EIGR 1613
IGR
Sbjct: 809 VIGR 812
Score = 82.0 bits (201), Expect = 5e-15
Identities = 78/293 (26%), Positives = 126/293 (43%), Gaps = 41/293 (13%)
Query: 1469 EEGAAARD---GRLWAG--DQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHY 1523
+ G AA+D R W+ DQ+L G R S L K ++ EA
Sbjct: 2559 DTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQS------VLSSVGSKSTILTLIQEAKA 2612
Query: 1524 RDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQGDQIL 1581
+ E ++ + L +K G GLG S+ G + + + + GAA +G + +GD +L
Sbjct: 2613 QSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLL 2672
Query: 1582 SVNGEDMRNASQETVATILKCAQ----GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAH 1637
SVNG + + V +L AQ LV ++ G + + N +G
Sbjct: 2673 SVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKG------ 2726
Query: 1638 SSCHPSFAPVITGLQNLVGTKRVS-DPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696
L+ K + +P S + VE+ + S LG+S+ GG+
Sbjct: 2727 ----------------LLSRKTIPLEPGIGRSVAVHDALCVEVLKT-SAGLGLSLDGGKS 2769
Query: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
S GD P+ I + G A + ++ GD I++ING+PL GL H D N++K+
Sbjct: 2770 SVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKS 2822
Score = 77.8 bits (190), Expect = 9e-14
Identities = 91/361 (25%), Positives = 146/361 (40%), Gaps = 41/361 (11%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
GLG V R I V V+ G A RD RL D++L IN L +SH++A+
Sbjct: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL-VGLSHEEAV 401
Query: 204 ALLQQTTGSLRLIVAREPVHTKS---STSSSLNDTTLPETVCWGHVEEVELINDGSGLGF 260
A+L+ TG ++L+VA + + TS SL D T VE+V D
Sbjct: 402 AILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-------SSVEDVSSWTDNEDQEA 454
Query: 261 GIVGGKTSGVVVRTIVPG--------GLADRDGRLQT---GDHILKI-----GGTNVQGM 304
+ + V+ +PG G + G L++ G + +K+ GG +
Sbjct: 455 DGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLES 514
Query: 305 TSEQVAQVLRNCGNSVRML-VARD----------PAGDISVTPPAPAALPVALPTVASKG 353
E ++RN +RML V+RD + S +L T +
Sbjct: 515 VEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVES 574
Query: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
P + L ++ G+ LG I G G GI+VK+I P +A +G ++
Sbjct: 575 PWRLIRPSVISIIGLYKEKGKGLGFSIAG--GRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
Query: 414 VNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK-TSSSTSPLEPPSDRGTVVE 472
D+I+ V+G+ I+G + + + + + VR K S S +P P+
Sbjct: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
Query: 473 P 473
P
Sbjct: 693 P 693
Score = 75.9 bits (185), Expect = 3e-13
Identities = 64/237 (27%), Positives = 101/237 (42%), Gaps = 36/237 (15%)
Query: 132 IEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHT 191
I I + + GLGFS+ R G++ IFVK + P A D RLKE D+IL +N
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
Query: 192 PLDQNISHQQAIALLQQTTGSLRLIVAR----EPVHTKSSTSSSLNDTTLPETVCWGH-- 245
P+ + ++ Q+AI +Q L ++ R P T ST + ++ + P G
Sbjct: 644 PI-KGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702
Query: 246 -----------------------VEEVELINDGS-GLGFG----IVGGKTSGVVVRTIVP 277
V EV L + GLG G + G+ + ++ P
Sbjct: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAP 762
Query: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNC-GNSVRMLVARDPAGDIS 333
G +A + L GD IL++ NV+ +V +L C VR+++ R P +S
Sbjct: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVS 819
Score = 74.7 bits (182), Expect = 8e-13
Identities = 62/208 (29%), Positives = 92/208 (44%), Gaps = 27/208 (12%)
Query: 255 GSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQV 309
G GLGF I GG+ G+ V+TI P G A DGRL+ GD IL + G ++G+T ++
Sbjct: 594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 653
Query: 310 AQVLRNCGNSVRMLVARDPAGDISVTP-PAPAALP-VALPTVASKG--------PGSDSS 359
+ + + +L R S+TP P + A P + G GS SS
Sbjct: 654 IHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSS 713
Query: 360 LFE---------TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNG 410
L V L ++ LGI G + GIY+ S+ PGS A
Sbjct: 714 LGRKTPGPKDRIVMEVTLNKEPRVGLGI---GACCLALENSPPGIYIHSLAPGSVAKMES 770
Query: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVL 438
++ D+I+ V+ VN++ A V +L
Sbjct: 771 NLSRGDQILEVNSVNVRHAALSKVHAIL 798
Score = 74.7 bits (182), Expect = 8e-13
Identities = 65/212 (30%), Positives = 97/212 (45%), Gaps = 35/212 (16%)
Query: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501
K SGLG S+ GG D +I +H V+ +GAA+++G + GD +L VNG L +H
Sbjct: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
Query: 1502 ITALRQTP-QKVRLVVYR---DEAHYRDEEN---------LEIFPVDLQKKAGR------ 1542
+ L Q K LVV + D+ + L + L+ GR
Sbjct: 2688 LKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHD 2747
Query: 1543 -----------GLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGDQILSVNGED 1587
GLGLS+ G ++ G G + I + KGGAA+ G + GD+IL++NG+
Sbjct: 2748 ALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKP 2807
Query: 1588 MRNASQETVATILKCA-QGLVQLEIGRLRAGS 1618
+ I+K +G VQL I + R S
Sbjct: 2808 LVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS 2839
Score = 72.4 bits (176), Expect = 4e-12
Identities = 82/308 (26%), Positives = 127/308 (41%), Gaps = 48/308 (15%)
Query: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI--------------IKT 1309
I+V + PA G++R+ DE+L +N Q++ G AS + ++
Sbjct: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRR 178
Query: 1310 APSKVKLVFIRNEDAVNQMAVTPF----------------------PVPSSSPSSIEDQS 1347
K + N ++ TP P + +P + +
Sbjct: 179 FKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSA 238
Query: 1348 GTEPISSEEDGSVEVGIK-QLPESESFKL--AVSQMKQQKYP----TKVSFSSQE-IPLA 1399
G E +SS+ +E G +L F+L +K+ P ++V ++ IP
Sbjct: 239 GCE-VSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKT 297
Query: 1400 PASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPL 1459
A S D GG S D V G+ +E+ K GLG+ + GG+ +
Sbjct: 298 DAPLTTSNDKRRFSKGGKTDFQSSDCLAREEV-GRIWKMELLKESDGLGIQVSGGRGSKR 356
Query: 1460 N--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY 1517
+ AIV+ +V E GAA RDGRL GD++L +NG L SHEEA+ LR V+LVV
Sbjct: 357 SPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVA 416
Query: 1518 RDEAHYRD 1525
E D
Sbjct: 417 SKENSAED 424
Score = 70.1 bits (170), Expect = 2e-11
Identities = 76/275 (27%), Positives = 112/275 (40%), Gaps = 75/275 (27%)
Query: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
I+ K+ +GLG S+AG D SI V + +G A+ +G M GD LL +N L G
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
Query: 1299 SHQNASAIIKTAP-SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEED 1357
+H N ++ A K LV I+ ++Q P PS+ EP ++
Sbjct: 2683 AHGNVLKVLHQAQLHKDALVVIKK--GMDQ------PRPSAR---------QEPPTANGK 2725
Query: 1358 GSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGF 1417
G + S + IPL P G
Sbjct: 2726 GLL-------------------------------SRKTIPLEP---------------GI 2739
Query: 1418 QAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKD--TPLNAIVIHEVYEEGAAAR 1475
++V A C +E+ K +GLGLS+ GGK T +VI VY+ GAA +
Sbjct: 2740 GRSVAVHDALC---------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQ 2790
Query: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1510
G + AGD+IL +NG L H +A ++ P+
Sbjct: 2791 AGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
Score = 68.2 bits (165), Expect = 7e-11
Identities = 73/266 (27%), Positives = 118/266 (44%), Gaps = 27/266 (10%)
Query: 1474 ARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFP 1533
+RDGR + Q+L+ + +++ +L T + E+ +R I
Sbjct: 536 SRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTT---------QVESPWRLIRPSVISI 586
Query: 1534 VDLQKKAGRGLGLSIVGKRN----GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMR 1589
+ L K+ G+GLG SI G R+ G+F+ I G+A DGRL +GD+IL VNG ++
Sbjct: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
Query: 1590 NAS-QETVATILKCAQGLVQLEI-GRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPV 1647
+ QE + T + GL L + +L + S T T + S+ + + ++S S
Sbjct: 647 GLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGS 706
Query: 1648 ITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIA--GGRGSPLGDIPVF 1705
G + +G K P K D V +N+E LGI SP G ++
Sbjct: 707 DEGSSSSLGRK---TPGPK----DRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IY 756
Query: 1706 IAMIQASGVAARTQKLKVGDRIVSIN 1731
I + VA L GD+I+ +N
Sbjct: 757 IHSLAPGSVAKMESNLSRGDQILEVN 782
Score = 66.2 bits (160), Expect = 3e-10
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 9/158 (5%)
Query: 1234 PGELHIIELEKDKN-GLGLSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
P + II L K+K GLG S+AG +D R +M IFV I P G AA DGR++ GDE+L++
Sbjct: 581 PSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDV 640
Query: 1291 NNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPS----SSPSSIEDQ 1346
N + G + Q A K S + ++ +R + + ++TP P+ S+ +
Sbjct: 641 NGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK--LVSPSLTPCSTPTHMSRSASPNFNTS 698
Query: 1347 SGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQK 1384
G S+E S +G K + + V+ K+ +
Sbjct: 699 GGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR 736
Score = 66.2 bits (160), Expect = 3e-10
Identities = 57/219 (26%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 254 DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
+GSGLGF + GG + + V + G A ++G + GD +L + G ++ G+ V
Sbjct: 2629 EGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVL 2688
Query: 311 QVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKG----------PGSDSSL 360
+VL LV D P P+A PT KG PG S+
Sbjct: 2689 KVLHQAQLHKDALVVIKKGMD----QPRPSARQEP-PTANGKGLLSRKTIPLEPGIGRSV 2743
Query: 361 --FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKI 418
+ VE++ K LG+ + G G S + +K + G AA G I+ D+I
Sbjct: 2744 AVHDALCVEVL-KTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEI 2800
Query: 419 VAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
+A++G + G + D ++++ + L+R+ +SS
Sbjct: 2801 LAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS 2839
Score = 63.2 bits (152), Expect = 2e-09
Identities = 33/92 (35%), Positives = 52/92 (56%)
Query: 1684 SDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADV 1743
SD LGI ++GGRGS + + ++ G A R +L +GD ++ ING L GLSH +
Sbjct: 341 SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEA 400
Query: 1744 VNLLKNAYGRIILQVVADTNISAIAAQLENMS 1775
V +L++A G + L V + N + +L + S
Sbjct: 401 VAILRSATGMVQLVVASKENSAEDLLRLTSKS 432
Score = 62.8 bits (151), Expect = 3e-09
Identities = 114/504 (22%), Positives = 206/504 (40%), Gaps = 80/504 (15%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
+E+ +E + LGI + GG+ KR + I + QV E A + L GD++L +
Sbjct: 335 MELLKESD-GLGIQVSGGRGS-KRSPHA-----IVVTQVKEGGAAHRDGRLSLGDELLVI 387
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQS--------LSSTPRVIPNVHNKANKITG-N 1179
+G L SH EAV +++A V +V S L T + +P++ + ++
Sbjct: 388 NGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWT 447
Query: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTD-----DSDENEEEDAFTDQKIRQRYADLP 1234
N+D + E+ +GT+ + P D +S N E KI+ + + L
Sbjct: 448 DNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLK-SRLS 506
Query: 1235 GELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294
G +H +E ++ N L + R RM + DGR +LL+ ++
Sbjct: 507 GGVHRLESVEEYN--ELMVRNGDPRIRML----------EVSRDGRKHSLPQLLDSSSAS 554
Query: 1295 LYGRSHQNASAIIKTA----------PSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIE 1344
+ ++ + T PS + ++ + E F + + I
Sbjct: 555 QEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKG----LGFSI-AGGRDCIR 609
Query: 1345 DQSG--TEPI----SSEEDGSVEVG-----IKQLP-ESESFKLAVSQMKQQK-------Y 1385
Q G + I S+ EDG ++ G + +P + +F+ A+ KQ +
Sbjct: 610 GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
Query: 1386 PTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPI-----VPGQEMIIEI 1440
TK+ S P S +F GG A S + ++ + P +++E+
Sbjct: 670 RTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEV 729
Query: 1441 SKGRS-----GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
+ + G+G + +++P I IH + A + L GDQILEVN V++R+
Sbjct: 730 TLNKEPRVGLGIGACCLALENSP-PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
Query: 1496 SSHEEAITALRQTPQ-KVRLVVYR 1518
++ + L + P VRLV+ R
Sbjct: 789 AALSKVHAILSKCPPGPVRLVIGR 812
Score = 60.1 bits (144), Expect = 2e-08
Identities = 31/87 (35%), Positives = 50/87 (57%), Gaps = 5/87 (5%)
Query: 244 GHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
G + ++EL+ + GLG + GG+ S +VV + GG A RDGRL GD +L I G
Sbjct: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
Query: 299 TNVQGMTSEQVAQVLRNCGNSVRMLVA 325
+ G++ E+ +LR+ V+++VA
Sbjct: 390 HLLVGLSHEEAVAILRSATGMVQLVVA 416
Score = 58.2 bits (139), Expect = 7e-08
Identities = 36/107 (33%), Positives = 59/107 (55%), Gaps = 5/107 (4%)
Query: 1526 EENLEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQIL 1581
EE I+ ++L K++ GLG+ + G KR+ + ++ + +GGAA DGRL GD++L
Sbjct: 327 EEVGRIWKMELLKESD-GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELL 385
Query: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQN 1628
+NG + S E IL+ A G+VQL + + R TS++
Sbjct: 386 VINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKS 432
Score = 57.4 bits (137), Expect = 1e-07
Identities = 75/358 (20%), Positives = 142/358 (39%), Gaps = 53/358 (14%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
I+ +++E LG SI GG+ I+ G+ GIF+K + + A + LK GD+IL+
Sbjct: 586 IIGLYKEKGKGLGFSIAGGRDCIR----GQ--MGIFVKTIFPNGSAAEDGRLKEGDEILD 639
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFI-----VQSLSSTPRVIPNVHNKANKITGNQNQ 1182
V+G+ ++ + EA+ K + + + + S S TP P +++ N +
Sbjct: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSG 699
Query: 1183 DTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
++ K P P + + N+E
Sbjct: 700 GASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKE------------------------- 734
Query: 1243 EKDKNGLGL-SLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301
+ GLG+ + + S I++ + P A + + GD++LE+N+ + +
Sbjct: 735 --PRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALS 792
Query: 1302 NASAII-KTAPSKVKLVFIRNED-AVNQMAVTPFPVPSSSPSSIEDQSGT---EPISSEE 1356
AI+ K P V+LV R+ + V++ + S+ S E S P+ S
Sbjct: 793 KVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPS 852
Query: 1357 DGSVEVGIKQLPESESF---------KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYH 1405
+ I + S+ F V+ + + +P +S+E L P++S H
Sbjct: 853 LAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTH 910
Score = 54.3 bits (129), Expect = 1e-06
Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
+ + +E LG SIAGGR G + +F+ I +G AA +LK GD I+ +NG P+
Sbjct: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
Query: 1737 GLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHL 1780
GL+ + ++ K + + V ++ L ST H+
Sbjct: 647 GLTFQEAIHTFKQIRSGLFVLTV---RTKLVSPSLTPCSTPTHM 687
Score = 50.4 bits (119), Expect = 2e-05
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 27/216 (12%)
Query: 134 YIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPL 193
+I + R GLGFSV ++ I V V A ++ + D +L++N L
Sbjct: 2622 FIVLNRKEGSGLGFSVAG--GTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASL 2679
Query: 194 ------------DQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLP--- 238
Q H+ A+ ++++ R +EP ++ L+ T+P
Sbjct: 2680 AGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEP--PTANGKGLLSRKTIPLEP 2737
Query: 239 ---ETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTG 290
+V VE++ +GLG + GGK+S +V++ + GG A++ G ++ G
Sbjct: 2738 GIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
Query: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
D IL I G + G+ ++++ L+ R
Sbjct: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
Score = 49.3 bits (116), Expect = 3e-05
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 31/234 (13%)
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
++ +I G G L+ DE+L+VNG+ + G + +EA+ K++ ++ R
Sbjct: 615 FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR---- 670
Query: 642 DEASVDEPRRTETSLPETEVDHNMDVN-----------TEEDDDGELALWSPEVKI---- 686
+ P T S P T + + N ++E L +P K
Sbjct: 671 --TKLVSPSLTPCSTP-THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVM 727
Query: 687 -VELVKDCK---GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
V L K+ + G+G L L+ + I I SL VA+ L GD+++ VN
Sbjct: 728 EVTLNKEPRVGLGIGACCL----ALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNS 783
Query: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICK-PLVEDNEEESCYILHSSSNEDKTE 795
+ + +L++ IL PPG V L I + P + +E+E ++ S+ ++ E
Sbjct: 784 VNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
Score = 43.1 bits (100), Expect = 0.002
Identities = 30/130 (23%), Positives = 54/130 (41%), Gaps = 8/130 (6%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
R + + + + GLG L +N I++ + PGSVA + L DQIL +N
Sbjct: 724 RIVMEVTLNKEPRVGLGIGACCLALEN-SPPGIYIHSLAPGSVAKMESNLSRGDQILEVN 782
Query: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEV 249
+ + L + G +RL++ R P + +++ + E + +E
Sbjct: 783 SVNVRHAALSKVHAILSKCPPGPVRLVIGRHP-------NPKVSEQEMDEVIARSTYQES 835
Query: 250 ELINDGSGLG 259
+ N GLG
Sbjct: 836 KEANSSPGLG 845
Score = 43.1 bits (100), Expect = 0.002
Identities = 50/194 (25%), Positives = 81/194 (41%), Gaps = 14/194 (7%)
Query: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP-PPFTLVCCRRLFD 641
+ + S G G + D LL VNG L G + + L + LV ++
Sbjct: 2650 VHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKK--- 2706
Query: 642 DEASVDEPRRTETSLPETEVDHNM----DVNTEEDDDGELALWSPEVKIVELVKDCKGLG 697
+D+PR + P T + + E +A+ + VE++K GLG
Sbjct: 2707 ---GMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH--DALCVEVLKTSAGLG 2761
Query: 698 FSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL 757
S LD +VI+ + G AE++G + GD ++++N L +A I+
Sbjct: 2762 LS-LDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
Query: 758 KAVPPGLVHLGICK 771
K+VP G V L I K
Sbjct: 2821 KSVPEGPVQLLIRK 2834
Score = 42.7 bits (99), Expect = 0.003
Identities = 25/74 (33%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
+ +NR+ LG S+AGG I V Q G A++ + GD ++S+NG L
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLA 2680
Query: 1737 GLSHADVVNLLKNA 1750
GL+H +V+ +L A
Sbjct: 2681 GLAHGNVLKVLHQA 2694
Score = 42.4 bits (98), Expect = 0.004
Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 8/119 (6%)
Query: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
+EL+K+ GLG + + +++V + + G A R G L GD L+ +N + L
Sbjct: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQ-VKEGGAAHRDGRLSLGDELLVINGHLLV 393
Query: 747 NTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINS 805
S EAV IL++ G+V L + ++N E L S S D T ++ D++S
Sbjct: 394 GLSHEEAVAILRSA-TGMVQLVVAS---KENSAEDLLRLTSKSLPDLT---SSVEDVSS 445
Score = 41.2 bits (95), Expect = 0.009
Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 8/158 (5%)
Query: 684 VKIVELVKDC-KGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
+ I+ L K+ KGLGFSI +D + + V +++ +G A G L GD ++ VN
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV-KTIFPNGSAAEDGRLKEGDEILDVNG 642
Query: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSS------NEDKTEF 796
+ + EA+ K + GL L + LV + H S N
Sbjct: 643 IPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702
Query: 797 SGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLG 834
+G + +SS + G +D + L EP + LG
Sbjct: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
Score = 40.0 bits (92), Expect = 0.020
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 1240 IELEKDKNGLGLSLAGNKDRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINNQILYG 1297
+E+ K GLGLSL G K + + + G A G + GDE+L IN + L G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
Query: 1298 RSHQNASAIIKTAPSKVKLVFIR 1320
H +A I+K+ P + IR
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLIR 2833
Score = 39.7 bits (91), Expect = 0.027
Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 17/144 (11%)
Query: 547 DTQIADDAELQKYSKLLPIHTLR----LGVEVDSFDGHH------YISSIVSGGPVDTLG 596
D Q +D ++ ++ + L+ LG++V G ++ + GG G
Sbjct: 317 DFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDG 376
Query: 597 LLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSL 656
L DELL +NG L G S EAV+ L+ LV + + ++ D R T SL
Sbjct: 377 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASK---ENSAEDLLRLTSKSL 433
Query: 657 PE----TEVDHNMDVNTEEDDDGE 676
P+ E + N +++ DGE
Sbjct: 434 PDLTSSVEDVSSWTDNEDQEADGE 457
Score = 37.4 bits (85), Expect = 0.13
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 628
DG I + GG + G+++ DE+L +NG L G +A + +K VP
Sbjct: 2774 DGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP 2824
Score = 35.0 bits (79), Expect = 0.66
Identities = 20/76 (26%), Positives = 32/76 (42%), Gaps = 8/76 (10%)
Query: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
R+ LG S+ GG V E K I + +V A + + GD +L V+G
Sbjct: 2627 RKEGSGLGFSVAGGTDV--------EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGAS 2678
Query: 1133 LQNASHSEAVEAIKNA 1148
L +H ++ + A
Sbjct: 2679 LAGLAHGNVLKVLHQA 2694
Score = 33.5 bits (75), Expect = 1.9
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 141 STGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQ 200
++ GLG S+ +S G + +K V G A++ ++ D+ILAIN PL + H
Sbjct: 2756 TSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL-VGLMHF 2814
Query: 201 QAIALLQQT-TGSLRLIVAREPVHTKSS 227
A +++ G ++L++ + H SS
Sbjct: 2815 DAWNIMKSVPEGPVQLLIRK---HRNSS 2839
Score = 31.2 bits (69), Expect = 9.5
Identities = 40/178 (22%), Positives = 73/178 (41%), Gaps = 27/178 (15%)
Query: 1102 IFIKQVLEDSPAGKTNALKTGDKILEVS-----GVDLQNASHSEAVEAIKNAGNPVVFIV 1156
I++ ++ ++SPAGK+ ++ D+IL ++ GVD+ AS+ E N G + ++
Sbjct: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASY--LAEQCWNGGFIYLIML 176
Query: 1157 QSLSSTPRVIPNVHNKANKITGN----QNQDTQEKKEKRQG-----TAPPPMKLPPPYKA 1207
+ N ++ + G + D KK KR + PP K P K
Sbjct: 177 RRFKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKG 236
Query: 1208 LTD---DSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRM 1262
SD + E + D ++ G H+ +LE + L + +RS +
Sbjct: 237 SAGCEVSSDPSTELENGPDPEL--------GNGHVFQLENGPDSLKEVAGPHLERSEV 286
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 119 bits (297), Expect = 3e-26
Identities = 156/665 (23%), Positives = 253/665 (38%), Gaps = 105/665 (15%)
Query: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI 1239
Q Q T+E E PP + PP + + FT + ++L G+
Sbjct: 418 QQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFT-----RNPSELKGKFIH 472
Query: 1240 IELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRS 1299
+L K G G ++ G + + + + +GPAA DG+M GD ++ +N+ + G +
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531
Query: 1300 HQNASAIIKTAP--SKVKLVFIR------NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
H I ++ P + V L R + D N VT + P + Q +
Sbjct: 532 HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591
Query: 1352 ISSEEDGSVEV-GIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPA--------- 1401
+S + +V G+K S +A + YP + I P
Sbjct: 592 PASHSSKTGKVNGMKDARPSSPADVASNS--SHGYPNDTVSLASSIATQPELITVHIVKG 649
Query: 1402 -SSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKG----------------- 1443
+ T AD G GG + VD C + ++I+E++K
Sbjct: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
Query: 1444 -----------RSGLGLSIVGGKDTPL----------NAIVIHEVYEEGAAARDGRLWAG 1482
R GL + K PL +++ H + + ++
Sbjct: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
Query: 1483 DQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGR 1542
E D +SS ++ + Q + E D + +IF +K+ G
Sbjct: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMY----ENRLPDYQEQDIFL--WRKETGF 823
Query: 1543 GLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
G + + G G ++I IV GAAD DGRL GD+++ V+G + S + V +++
Sbjct: 824 GFRI-LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882
Query: 1603 A--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP----VITGLQNLVG 1656
A QG V L + R + T S HSS P+ G QN +
Sbjct: 883 AAKQGHVNLTVRRKVV---FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN 939
Query: 1657 TKRVSDPSQKNSG-------------TDMEPRTVEINRELSDALGISIAGG-----RGSP 1698
T VS S SG T ++P VEI R ++ G I G+
Sbjct: 940 T--VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 997
Query: 1699 LGD----IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRI 1754
G+ +P I I A R KLKVGDRI+++NG + SH+D+VNL+K A +
Sbjct: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
Query: 1755 ILQVV 1759
L+++
Sbjct: 1058 TLRII 1062
Score = 104 bits (260), Expect = 7e-22
Identities = 86/294 (29%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIK------QVLEDSPAGKTNAL 1119
P VEI R N G IV + R + G + +++E SPA + L
Sbjct: 968 PYDVEIRRGENEGFGFVIVSS---VSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKL 1024
Query: 1120 KTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--FIVQSLSSTPRVIPNVHNKANKIT 1177
K GD+IL V+G + N SHS+ V IK AGN V I SS ++ N A T
Sbjct: 1025 KVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITT 1084
Query: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
+ +Q+ ++ + T P + +KA +E+D +T
Sbjct: 1085 --THTPSQQGTQETRNTTKPKQESQFEFKA----PQATQEQDFYT--------------- 1123
Query: 1238 HIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYG 1297
+ELE+ G G SL G ++ + M ++V+ + +GPA G+MRIGDE+LEIN +
Sbjct: 1124 --VELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1180
Query: 1298 RSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
H A +IK +V+L R + + VP PSS T P
Sbjct: 1181 MKHSRAIELIKNGGRRVRLFLKRGDGS----------VPEYDPSSDRHGPATGP 1224
Score = 97.1 bits (240), Expect = 1e-19
Identities = 144/628 (22%), Positives = 239/628 (38%), Gaps = 132/628 (21%)
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA--GNPVVFIVQSLS- 1160
+KQ++ DSP + LK GD I+EV+ ++Q +H++ V+ + G+ V +VQ
Sbjct: 668 VKQIV-DSP--RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
Query: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAP----------PPMKLPPPYKALTD 1210
P+ P K + N +Q + +P PP + P + TD
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ--TD 782
Query: 1211 DSDENEEEDAFTDQKIRQRYAD-LPG-ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVG 1268
S + + + + R Y + LP + I L + + G G + G + I++
Sbjct: 783 SSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGE-PIYIGH 841
Query: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQM 1328
I P G A DGR+R GDEL+ ++ + G+SHQ +++ A + + V +
Sbjct: 842 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV 901
Query: 1329 AVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTK 1388
T VPS + S S +P S E+ K+ P+
Sbjct: 902 PKTENEVPSPASS---HHSSNQPASLTEE-------KRTPQ------------------- 932
Query: 1389 VSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS-GL 1447
SQ +S ST +G GG +S +V Q +EI +G + G
Sbjct: 933 ---GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVST------VV--QPYDVEIRRGENEGF 981
Query: 1448 GLSIVGGKDTPL------NAIV-----IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496
G IV P NA V I + E A R G+L GD+IL VNG + N
Sbjct: 982 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1041
Query: 1497 SHEEAITALRQTPQKVRLVVY----------------------------------RDEAH 1522
SH + + +++ V L + R+
Sbjct: 1042 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1101
Query: 1523 YRDEENLE-----------IFPVDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADL 1570
+ E E + V+L++ A +G G S+ G R +++ + + G A+
Sbjct: 1102 PKQESQFEFKAPQATQEQDFYTVELERGA-KGFGFSLRGGREYNMDLYVLRLAEDGPAER 1160
Query: 1571 DGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR------------LRAGS 1618
G++ GD+IL +NGE +N ++K V+L + R R G
Sbjct: 1161 CGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGP 1220
Query: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAP 1646
T + + G + H S S+ P
Sbjct: 1221 ATGPQGVPEVRAGPDRRQHPSLESSYPP 1248
Score = 93.6 bits (231), Expect = 2e-18
Identities = 109/444 (24%), Positives = 189/444 (42%), Gaps = 97/444 (21%)
Query: 229 SSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGR 286
S S+ + LP+ +++ L +G GF I+GG G + + IVP G AD DGR
Sbjct: 798 SRSMYENRLPDY----QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGR 853
Query: 287 LQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS--VRMLVARD-----PAGDISVTPPA- 338
L++GD ++ + GT V G + + V Q+++ V + V R P + V PA
Sbjct: 854 LRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 913
Query: 339 -------PAALPV----------ALPTVASK-------------GPGSDSSLFETYNVEL 368
PA+L +L TV+S G G S++ + Y+VE+
Sbjct: 914 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 973
Query: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIY-------VKSIIPGSAAYHNGHIQVNDKIVAV 421
R + + G IV V G G + II GS A G ++V D+I+AV
Sbjct: 974 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1033
Query: 422 DGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFL 481
+G +I ++ D+V +++ AG V L ++ SS+ A L
Sbjct: 1034 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN--------------------ATLL 1073
Query: 482 TGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEV 541
T A E+I T+ + + + ++ ++ + + +S++E ++
Sbjct: 1074 TNA---------------EKIATITTTHTPSQQGTQETRNTTKPKQESQFE------FKA 1112
Query: 542 MVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPE 601
AT + Q EL++ +K +LR G E ++ Y+ + GP + G ++
Sbjct: 1113 PQATQE-QDFYTVELERGAKGFGF-SLRGGRE---YNMDLYVLRLAEDGPAERCGKMRIG 1167
Query: 602 DELLEVNGMQLYGKSRREAVSFLK 625
DE+LE+NG A+ +K
Sbjct: 1168 DEILEINGETTKNMKHSRAIELIK 1191
Score = 73.6 bits (179), Expect = 2e-12
Identities = 84/407 (20%), Positives = 155/407 (38%), Gaps = 94/407 (23%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
G GF ++ N I++ + P AD D RL+ D+++ ++ TP+ SHQ +
Sbjct: 822 GFGFRILG---GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 877
Query: 204 ALLQQTT--GSLRLIVAREPVHTKSST-------SSSLNDTTLPETVC------WGHVEE 248
L+QQ G + L V R+ V T +SS + + P ++ G
Sbjct: 878 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS 937
Query: 249 VELINDGSGL--GFGIVGGKTSGVV----------------------------------- 271
+ ++ GSG G G GG SGVV
Sbjct: 938 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 997
Query: 272 -----------VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV 320
+ I+ G ADR G+L+ GD IL + G ++ + + +++ GN+V
Sbjct: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
Query: 321 RM-LVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ----- 374
+ ++ D + + ++ A + T+ + S ET N +++ Q
Sbjct: 1058 TLRIIPGDESSNATLLTNAEK-----IATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1112
Query: 375 --------------SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
G + G+ +YV + A G +++ D+I+
Sbjct: 1113 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1172
Query: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDR 467
++G + + +E+++N G+ V L L ++ S +P SDR
Sbjct: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFL--KRGDGSVPEYDPSSDR 1217
Score = 73.2 bits (178), Expect = 2e-12
Identities = 104/546 (19%), Positives = 206/546 (37%), Gaps = 109/546 (19%)
Query: 1007 QRREQEDLPLYQHQATRVISKAS-AYTGMLSSRYATDTCELPEREEGEGEETPN-FSHWG 1064
+R++ ++ + + R + AS +++ + + + P++ + G++ P+ F W
Sbjct: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWA 796
Query: 1065 PPRIVEIFREPN------------VSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSP 1112
R + R P+ G I+GG E + I+I ++
Sbjct: 797 QSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGN---------EPGEPIYIGHIVPLGA 847
Query: 1113 AGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNK 1172
A L++GD+++ V G + SH V+ ++ A + +P N+
Sbjct: 848 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 907
Query: 1173 -----ANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIR 1227
++ + NQ E+K QG + + T + +
Sbjct: 908 VPSPASSHHSSNQPASLTEEKRTPQG-SQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV 966
Query: 1228 QRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSRMSI----------FVVGINPEG-PA 1275
Q Y +E+ + +N G G + + R +G EG PA
Sbjct: 967 QPYD--------VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1018
Query: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
G++++GD +L +N + +SH + +IK A + V L I +++ N +T
Sbjct: 1019 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLT---- 1074
Query: 1336 PSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESES-FKLAVSQMKQQKYPTKVSFSSQ 1394
++ + + T + + G+ E P+ ES F+ Q Q++
Sbjct: 1075 -----NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ---------- 1119
Query: 1395 EIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGG 1454
DF +E+ +G G G S+ GG
Sbjct: 1120 ---------------DF------------------------YTVELERGAKGFGFSLRGG 1140
Query: 1455 KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRL 1514
++ ++ V+ + E+G A R G++ GD+ILE+NG +N H AI ++ ++VRL
Sbjct: 1141 REYNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
Query: 1515 VVYRDE 1520
+ R +
Sbjct: 1200 FLKRGD 1205
Score = 71.6 bits (174), Expect = 6e-12
Identities = 56/203 (27%), Positives = 95/203 (46%), Gaps = 17/203 (8%)
Query: 1559 ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGS 1618
I I++G AD G+L GD+IL+VNG + N S + ++K A V L R+ G
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL---RIIPGD 1065
Query: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQ-----KNSGTDME 1673
+S T N++ ++ + P G Q T + SQ + + +
Sbjct: 1066 ESSNATLLTNAEKI-----ATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD 1120
Query: 1674 PRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733
TVE+ R + G S+ GGR ++ +++ + G A R K+++GD I+ ING+
Sbjct: 1121 FYTVELERG-AKGFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGE 1176
Query: 1734 PLDGLSHADVVNLLKNAYGRIIL 1756
+ H+ + L+KN R+ L
Sbjct: 1177 TTKNMKHSRAIELIKNGGRRVRL 1199
Score = 65.9 bits (159), Expect = 3e-10
Identities = 71/266 (26%), Positives = 110/266 (41%), Gaps = 48/266 (18%)
Query: 135 IDIERPSTGGLGFSVVALRSQ-----NLGKVDIFVKD----VQPGSVADRDQRLKENDQI 185
++I R G GF +V+ S+ G + + + GS ADR +LK D+I
Sbjct: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
Query: 186 LAINHTPLDQNISHQQAIALLQQT--TGSLRLIVAREP-----------------VHTKS 226
LA+N + N SH + L+++ T +LR+I E HT S
Sbjct: 1031 LAVNGCSIT-NKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
Query: 227 S--TSSSLNDTT----------LPETVCWGHVEEVELINDGSGLGFGIVGGK--TSGVVV 272
T + N T P+ VEL G GF + GG+ + V
Sbjct: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1149
Query: 273 RTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----P 328
+ G A+R G+++ GD IL+I G + M + ++++N G VR+ + R P
Sbjct: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVP 1209
Query: 329 AGDISVTPPAPAALPVALPTVASKGP 354
D S PA P +P V + GP
Sbjct: 1210 EYDPSSDRHGPATGPQGVPEVRA-GP 1234
Score = 63.5 bits (153), Expect = 2e-09
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 581 HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLF 640
H I I+ G P D G L+ D +L VNG + KS + V+ +KE TL R +
Sbjct: 1007 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL---RIIP 1063
Query: 641 DDEAS----VDEPRR----TETSLPETEVDHNMDVNTEEDDDGELALWSPEVK------I 686
DE+S + + T T P + T+ + + +P+
Sbjct: 1064 GDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1123
Query: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
VEL + KG GFS+ + + + V+R L DG AER G + GD ++ +N
Sbjct: 1124 VELERGAKGFGFSL---RGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTK 1179
Query: 747 NTSLAEAVEILK 758
N + A+E++K
Sbjct: 1180 NMKHSRAIELIK 1191
Score = 51.2 bits (121), Expect = 9e-06
Identities = 35/109 (32%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 688 ELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
+L K +G GF+++ +P + + I+SLV DG A G + GD +VSVN+ C+
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 748 TSLAEAVEILKAVPPGL-VHLGICK--PLVEDNEEESCYILHSSSNEDK 793
+ A+ V+I +++P G V L +C+ PL D ++ + ++ S + DK
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK 578
Score = 48.5 bits (114), Expect = 6e-05
Identities = 127/616 (20%), Positives = 215/616 (34%), Gaps = 133/616 (21%)
Query: 244 GHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNV 301
G +L G GF +VGG + ++++V G A DG+++TGD I+ + T V
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 302 QGMTSEQVAQVLRN--CGNSVRMLVAR------DP------------------------- 328
G T QV ++ ++ G SV + + R DP
Sbjct: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
Query: 329 -----------AGDISVTPPAPAALPVALPTVASKGPGSDSSLF--------ETYNVELV 369
G ++ A + P + + +S G +D+ E V +V
Sbjct: 588 TYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIV 647
Query: 370 RKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGF 429
K G I G G VK I+ ++ D IV V+ N+Q
Sbjct: 648 -KGPMGFGFTIADSPG------GGGQRVKQIVDSPRC---RGLKEGDLIVEVNKKNVQAL 697
Query: 430 ANHDVVEVLRNAGQVVHLTLVRR-------KTSSSTSPLEPPSDRGTVVEPLKPPALFLT 482
++ VV++L + +TL+ + K S + PLE + + + T
Sbjct: 698 THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHT 757
Query: 483 GAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVM 542
+ T V E + + D + + + P + +S +EN L PDY+
Sbjct: 758 ASPSHSTQVLPEFPPAEAQAP----DQTDSSGQKKPDPFKIWAQSRSMYENRL-PDYQ-- 810
Query: 543 VATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPED 602
+ ++ + K LG YI IV G DT G L+ D
Sbjct: 811 ----------EQDIFLWRKETGFGFRILGGNEPG--EPIYIGHIVPLGAADTDGRLRSGD 858
Query: 603 ELLEVNGMQLYGKSRREAVSFLK-------------------------EVPPPFTLVCCR 637
EL+ V+G + GKS + V ++ EVP P
Sbjct: 859 ELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSP---ASSH 915
Query: 638 RLFDDEASVDEPRRT----ETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVEL-VKD 692
+ AS+ E +RT + SL G + S V+ ++ ++
Sbjct: 916 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975
Query: 693 CKGLGFSILDYQDPLDPTRSVIV----------IRSLVADGVAERSGGLLPGDRLVSVNE 742
+ GF + P I ++ A+R G L GDR+++VN
Sbjct: 976 GENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNG 1035
Query: 743 YCLDNTSLAEAVEILK 758
+ N S ++ V ++K
Sbjct: 1036 CSITNKSHSDIVNLIK 1051
Score = 43.5 bits (101), Expect = 0.002
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 64 LNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVI 123
L IP D S+N LL + T H PS T PK ++ F
Sbjct: 1059 LRIIPGDESSNAT-----LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ-FEFKA 1112
Query: 124 QQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKEND 183
Q Q + +++ER + G GFS+ R N+ D++V + A+R +++ D
Sbjct: 1113 PQATQEQDFYTVELERGAKG-FGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGD 1168
Query: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+IL IN +N+ H +AI L++ +RL + R
Sbjct: 1169 EILEIN-GETTKNMKHSRAIELIKNGGRRVRLFLKR 1203
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 114 bits (284), Expect = 1e-24
Identities = 166/770 (21%), Positives = 296/770 (38%), Gaps = 156/770 (20%)
Query: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
++ + G +I+GG + L+ +K VL+D PA + + GD I++++G
Sbjct: 414 KKSTMGFGFTIIGGDRPDEFLQ---------VKNVLKDGPAAQDGKIAPGDVIVDINGNC 464
Query: 1133 LQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNK-------ANKITGNQNQDTQ 1185
+ +H++ V+ + PV V +P+ A + Q+
Sbjct: 465 VLGHTHADVVQMFQLV--PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522
Query: 1186 EKKEKRQGTAPPPMKLPPPYKA---LTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
E Q P M L K+ LT D N DA + EL I L
Sbjct: 523 ETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNGPSDASEQRVSMASSGSSQPELVTIPL 581
Query: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
K G G ++A + ++ + + +G ++ GD + EI +Q + +H
Sbjct: 582 IKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQ 634
Query: 1303 ASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
++K P + V L+ +R P P+ + D+ E GS+
Sbjct: 635 VVEVLKQFPVGADVPLLILRGGP----------PSPTKTAKMKTDKK-------ENAGSL 677
Query: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
E + +P+ F ++ + K E+ L + Y
Sbjct: 678 EAINEPIPQPMPFPPSIIRSGSPK------LDPSEVYLKSKTLYEDKP------------ 719
Query: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLW 1480
P T +++ + + K SG G ++GG D P +I I + GAA +DGRL
Sbjct: 720 ----PNT------KDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLR 768
Query: 1481 AGDQILEVNGVDLRNSSHEEAITALRQTPQK------VRLVVYRDEAHYRDEENL----- 1529
A D+++ ++G+ ++ SH++ + + + VR ++ E D+ +
Sbjct: 769 AADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIST 828
Query: 1530 -------------------EIFPVDLQKKAGRGLGLSIVGKRNGS--GVF---ISDIVKG 1565
E + V LQ+K G G I+ +N GV I +++G
Sbjct: 829 QNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEG 888
Query: 1566 GAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI-------------- 1611
AD G+L GD I +VNG+ + S + + ++K A V L +
Sbjct: 889 SPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTN 948
Query: 1612 -------------GRLRAGSWTSARTTSQNSQGSQQSA---HS-SCHPSFAPVITGLQNL 1654
G+ +A R+ + G S HS S H A T + ++
Sbjct: 949 SARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV 1008
Query: 1655 VGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGV 1714
VG S+ N P VE+ R G S+ GG+ +G +FI + G
Sbjct: 1009 VG-------SRHNQNLGCYP--VELERG-PRGFGFSLRGGKEYNMG---LFILRLAEDGP 1055
Query: 1715 AARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
A + ++ VGD+IV ING+P G++H + L++ +++L + T +
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGL 1105
Score = 85.9 bits (211), Expect = 3e-16
Identities = 72/265 (27%), Positives = 116/265 (43%), Gaps = 27/265 (10%)
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV------- 1156
I +V+E SPA + LK GD I V+G + SH V+ IK+AG V V
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941
Query: 1157 ------QSLSSTPRVI--PNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKAL 1208
S +P + P ++AN I G+++ E + + Y+
Sbjct: 942 GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKD----------VSTSYRHS 991
Query: 1209 TDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVG 1268
D + D + R+ G + +ELE+ G G SL G K+ + M +F++
Sbjct: 992 WSDHKHLAQPDTAVISVVGSRHNQNLG-CYPVELERGPRGFGFSLRGGKEYN-MGLFILR 1049
Query: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQM 1328
+ +GPA DGR+ +GD+++EIN + G +H A +I+ +KV L+ +
Sbjct: 1050 LAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDH 1109
Query: 1329 AVTPFPVPSSSPSSIEDQSGTEPIS 1353
PSSS ++QS P S
Sbjct: 1110 GDWDINNPSSSNVIYDEQSPLPPSS 1134
Score = 73.9 bits (180), Expect = 1e-12
Identities = 61/222 (27%), Positives = 105/222 (47%), Gaps = 31/222 (13%)
Query: 248 EVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
+V L SG GF ++GG + + I+P G A++DGRL+ D ++ I G V+G +
Sbjct: 726 DVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 306 SEQVAQVLRNCGNSVRMLVA---------RDPAGD-----ISVTPPAPAALPVALPTVAS 351
+QV ++ + +L+ + P D IS +P +P A
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVP--AR 843
Query: 352 KGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIY---VKSIIPGSAAYH 408
P E Y+V L RK+ + G I+ TS G+ + +I GS A
Sbjct: 844 PAPQ------EPYDVVLQRKENEGFGFVIL----TSKNKPPPGVIPHKIGRVIEGSPADR 893
Query: 409 NGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
G ++V D I AV+G +I ++ ++V+++++AG V LT++
Sbjct: 894 CGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
Score = 72.0 bits (175), Expect = 5e-12
Identities = 76/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 1515 VVYRDEAHYRDEE-NLEIFPVDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADLDG 1572
V + + Y D+ N + V L+K+ G G ++G ++I I+ GAA+ DG
Sbjct: 707 VYLKSKTLYEDKPPNTKDLDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDG 765
Query: 1573 RLIQGDQILSVNGEDMRNASQETVATILKCA--QGLVQLEIGRLRAGSWTSARTTSQNSQ 1630
RL D+++ ++G ++ S + V ++ A G V L + R +
Sbjct: 766 RLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR-------------KIFY 812
Query: 1631 GSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGIS 1690
G +Q S + QN G+ R++ EP V + R+ ++ G
Sbjct: 813 GEKQPEDDS-----SQAFISTQN--GSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865
Query: 1691 IAGGRGSPL-GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
I + P G IP I + A R KLKVGD I ++NGQ + LSH ++V L+K+
Sbjct: 866 ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925
Query: 1750 AYGRIILQVVAD---------TNISAIAAQLENMSTGYHLGSPTAEHHPED 1791
A + L V+A+ TN + + L++ +G A H P D
Sbjct: 926 AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP----MGQSQANHIPGD 972
Score = 70.5 bits (171), Expect = 1e-11
Identities = 102/485 (21%), Positives = 188/485 (38%), Gaps = 93/485 (19%)
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
R G GF V+ + I++ + P A++D RL+ D+++ I+ P+ + S
Sbjct: 730 RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPV-KGKS 785
Query: 199 HQQAIALLQQTT--GSLRLIVAREPVH--------------TKSSTSSSLNDTTLPETVC 242
H+Q + L+ G + L V R+ + + + S LN +P
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 243 WGHVEEVELIN-DGSGLGFGIVGGKTS---GVV---VRTIVPGGLADRDGRLQTGDHILK 295
+V L + G GF I+ K GV+ + ++ G ADR G+L+ GDHI
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD------PAGDISV-TPPAPAALPVALPT 348
+ G ++ ++ + + Q++++ G +V + V + P+G S PA P+ +
Sbjct: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMG-QS 964
Query: 349 VASKGPGSDSSLFETYNVELVRKDGQSLG---------IRIVGYVGTSHTGEAS------ 393
A+ PG S+L ++ S ++ VG+ H
Sbjct: 965 QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024
Query: 394 -------------------GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDV 434
G+++ + A +G I V D+IV ++G QG +
Sbjct: 1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRA 1084
Query: 435 VEVLRNAGQVVHLTL--------------VRRKTSSST-----SPLEPPSDRGTVVEPLK 475
+E+++ G V L L + +SS+ SPL P S ++ E
Sbjct: 1085 IELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESH 1144
Query: 476 PPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQ-----ALEKLEKVPDSPENELKSR 530
P + + V+ + + + E+ TL + + L+K D P + S
Sbjct: 1145 VPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSHGHSN 1204
Query: 531 WENLL 535
+NLL
Sbjct: 1205 KKNLL 1209
Score = 67.0 bits (162), Expect = 2e-10
Identities = 66/240 (27%), Positives = 110/240 (45%), Gaps = 44/240 (18%)
Query: 249 VELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQ 308
+ LI G GF I T G V+ I+ LQ GD I +I NVQ +T Q
Sbjct: 579 IPLIKGPKGFGFAIADSPT-GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQ 634
Query: 309 VAQVLRN--CGNSVRMLVAR-----------------DPAGDI-SVTPPAPAALPVALPT 348
V +VL+ G V +L+ R + AG + ++ P P +P
Sbjct: 635 VVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSI 694
Query: 349 VASKGPGSDSS--------LFE-----TYNVEL-VRKDGQSLGIRIVGYVGTSHTGEASG 394
+ S P D S L+E T ++++ +RK G R++G G +
Sbjct: 695 IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS----- 749
Query: 395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTL-VRRK 453
IY+ +IIP AA +G ++ D+++ +DG+ ++G ++ V++++ A + H+ L VRRK
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Score = 52.4 bits (124), Expect = 4e-06
Identities = 58/279 (20%), Positives = 106/279 (37%), Gaps = 37/279 (13%)
Query: 1231 ADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
+ L G L L+K G G ++ G DR + V + +GPAA DG++ GD +++I
Sbjct: 402 SQLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDI 460
Query: 1291 NNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTE 1350
N + G +H + + + P VN +P+P S + D
Sbjct: 461 NGNCVLGHTHADVVQMFQLVPV---------NQYVNLTLCRGYPLPDDSEDPVVDIVAAT 511
Query: 1351 PISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDAD 1410
P+ + + S+ G + + FK ++Q S H+ D
Sbjct: 512 PVINGQ--SLTKG-ETCMNPQDFKPGAMVLEQN-----------------GKSGHTLTGD 551
Query: 1411 FTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEE 1470
+ V A+ + + I + KG G G +I +++ + +
Sbjct: 552 GLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ 611
Query: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTP 1509
G L GD I E+ +++N +H + + L+Q P
Sbjct: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 10/89 (11%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
VE+ R P G S+ GG+ E G+FI ++ ED PA K + GD+I+E+
Sbjct: 1022 VELERGPR-GFGFSLRGGK---------EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
+G Q +H+ A+E I+ GN V+ +++
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
Score = 47.4 bits (111), Expect = 1e-04
Identities = 120/566 (21%), Positives = 201/566 (35%), Gaps = 124/566 (21%)
Query: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV-- 312
G GF I+GG + V+ ++ G A +DG++ GD I+ I G V G T V Q+
Sbjct: 419 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Query: 313 LRNCGNSVRMLVAR---------DPAGDISVTPPA-------------------PAALPV 344
L V + + R DP DI P P A+ +
Sbjct: 479 LVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVL 538
Query: 345 --------ALPTVASKGP-----------GSDSSLFETYNVELVRKDGQSLGIRIVGY-V 384
L GP S SS E + L++ G + G+ +
Sbjct: 539 EQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIK------GPKGFGFAI 592
Query: 385 GTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRN--AG 442
S TG+ VK I+ + + G +Q D I + N+Q + VVEVL+ G
Sbjct: 593 ADSPTGQK----VKMIL--DSQWCQG-LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVG 645
Query: 443 QVVHLTLVRRKTSSSTSPLEPPSDR-------GTVVEPLKPPALFLTGAVET-ETNVDGE 494
V L ++R S T + +D+ + EP+ P F + + +D
Sbjct: 646 ADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPS 705
Query: 495 DEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDA 554
+ +K + TL D + L+ E+ R GPD +
Sbjct: 706 EVYLKSK--TLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSI------------- 750
Query: 555 ELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYG 614
YI +I+ G + G L+ DEL+ ++G+ + G
Sbjct: 751 ---------------------------YIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
Query: 615 KSRREAVSFLKEVP--PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED 672
KS ++ + + L R++F E ++ ++S + +
Sbjct: 784 KSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPED----DSSQAFISTQNGSPRLNRAE 839
Query: 673 DDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLL 732
A P +V K+ +G GF IL ++ P I ++ A+R G L
Sbjct: 840 VPARPAPQEP-YDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLK 898
Query: 733 PGDRLVSVNEYCLDNTSLAEAVEILK 758
GD + +VN + S V+++K
Sbjct: 899 VGDHISAVNGQSIVELSHDNIVQLIK 924
Score = 46.6 bits (109), Expect = 2e-04
Identities = 28/94 (29%), Positives = 53/94 (56%), Gaps = 7/94 (7%)
Query: 689 LVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNT 748
L K G GF+I+ P + + +++++ DG A + G + PGD +V +N C+
Sbjct: 413 LKKSTMGFGFTIIGGDRPDE----FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 749 SLAEAVEILKAVPPG-LVHLGICK--PLVEDNEE 779
+ A+ V++ + VP V+L +C+ PL +D+E+
Sbjct: 469 THADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499
+ K G G +I+GG D P + + V ++G AA+DG++ GD I+++NG + +H
Sbjct: 413 LKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 1500 EAITALRQTP--QKVRLVVYR 1518
+ + + P Q V L + R
Sbjct: 472 DVVQMFQLVPVNQYVNLTLCR 492
Score = 38.9 bits (89), Expect = 0.046
Identities = 42/215 (19%), Positives = 80/215 (37%), Gaps = 40/215 (18%)
Query: 581 HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE--VPPPFTLVCCRR 638
H I ++ G P D G L+ D + VNG + S V +K+ V T++
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 639 LFDDEASVDEPRRT------------------ETSLPETEVDHNMDVNTEEDDDGELALW 680
+ + R++ + S E E+ ++ + L
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 681 SPEVKI----------------VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGV 724
P+ + VEL + +G GFS+ + + + ++R L DG
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 725 AERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
A + G + GD++V +N + A+E+++A
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQA 1090
Score = 37.7 bits (86), Expect = 0.10
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
+++ER G GFS+ + N+G +F+ + A +D R+ DQI+ IN P
Sbjct: 1022 VELER-GPRGFGFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEP-T 1076
Query: 195 QNISHQQAIALLQQTTGSLRLIV 217
Q I+H +AI L+Q + L++
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Score = 36.6 bits (83), Expect = 0.23
Identities = 55/264 (20%), Positives = 96/264 (36%), Gaps = 54/264 (20%)
Query: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP--FTLVCCRR-- 638
+ +++ GP G + P D ++++NG + G + + V + VP L CR
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYP 495
Query: 639 LFDDEAS--VDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWS--------------- 681
L DD VD T ++ +N ++ G + L
Sbjct: 496 LPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNG 555
Query: 682 ------------------PEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADG 723
PE+ + L+K KG GF+I D PT + ++ D
Sbjct: 556 PSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD-----SPTGQKV---KMILD- 606
Query: 724 VAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCY 783
++ GL GD + + + N + + VE+LK P +G PL+
Sbjct: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP-----VGADVPLLILRGGPPSP 660
Query: 784 ILHSSSNEDKTEFSGTIHDINSSL 807
+ DK E +G++ IN +
Sbjct: 661 TKTAKMKTDKKENAGSLEAINEPI 684
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 114 bits (284), Expect = 1e-24
Identities = 166/770 (21%), Positives = 296/770 (38%), Gaps = 156/770 (20%)
Query: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
++ + G +I+GG + L+ +K VL+D PA + + GD I++++G
Sbjct: 414 KKSTMGFGFTIIGGDRPDEFLQ---------VKNVLKDGPAAQDGKIAPGDVIVDINGNC 464
Query: 1133 LQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNK-------ANKITGNQNQDTQ 1185
+ +H++ V+ + PV V +P+ A + Q+
Sbjct: 465 VLGHTHADVVQMFQLV--PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522
Query: 1186 EKKEKRQGTAPPPMKLPPPYKA---LTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
E Q P M L K+ LT D N DA + EL I L
Sbjct: 523 ETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNGPSDASEQRVSMASSGSSQPELVTIPL 581
Query: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
K G G ++A + ++ + + +G ++ GD + EI +Q + +H
Sbjct: 582 IKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQ 634
Query: 1303 ASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
++K P + V L+ +R P P+ + D+ E GS+
Sbjct: 635 VVEVLKQFPVGADVPLLILRGGP----------PSPTKTAKMKTDKK-------ENAGSL 677
Query: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
E + +P+ F ++ + K E+ L + Y
Sbjct: 678 EAINEPIPQPMPFPPSIIRSGSPK------LDPSEVYLKSKTLYEDKP------------ 719
Query: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLW 1480
P T +++ + + K SG G ++GG D P +I I + GAA +DGRL
Sbjct: 720 ----PNT------KDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLR 768
Query: 1481 AGDQILEVNGVDLRNSSHEEAITALRQTPQK------VRLVVYRDEAHYRDEENL----- 1529
A D+++ ++G+ ++ SH++ + + + VR ++ E D+ +
Sbjct: 769 AADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIST 828
Query: 1530 -------------------EIFPVDLQKKAGRGLGLSIVGKRNGS--GVF---ISDIVKG 1565
E + V LQ+K G G I+ +N GV I +++G
Sbjct: 829 QNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEG 888
Query: 1566 GAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI-------------- 1611
AD G+L GD I +VNG+ + S + + ++K A V L +
Sbjct: 889 SPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTN 948
Query: 1612 -------------GRLRAGSWTSARTTSQNSQGSQQSA---HS-SCHPSFAPVITGLQNL 1654
G+ +A R+ + G S HS S H A T + ++
Sbjct: 949 SARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV 1008
Query: 1655 VGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGV 1714
VG S+ N P VE+ R G S+ GG+ +G +FI + G
Sbjct: 1009 VG-------SRHNQNLGCYP--VELERG-PRGFGFSLRGGKEYNMG---LFILRLAEDGP 1055
Query: 1715 AARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
A + ++ VGD+IV ING+P G++H + L++ +++L + T +
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGL 1105
Score = 73.9 bits (180), Expect = 1e-12
Identities = 61/222 (27%), Positives = 105/222 (47%), Gaps = 31/222 (13%)
Query: 248 EVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
+V L SG GF ++GG + + I+P G A++DGRL+ D ++ I G V+G +
Sbjct: 726 DVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 306 SEQVAQVLRNCGNSVRMLVA---------RDPAGD-----ISVTPPAPAALPVALPTVAS 351
+QV ++ + +L+ + P D IS +P +P A
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVP--AR 843
Query: 352 KGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIY---VKSIIPGSAAYH 408
P E Y+V L RK+ + G I+ TS G+ + +I GS A
Sbjct: 844 PAPQ------EPYDVVLQRKENEGFGFVIL----TSKNKPPPGVIPHKIGRVIEGSPADR 893
Query: 409 NGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
G ++V D I AV+G +I ++ ++V+++++AG V LT++
Sbjct: 894 CGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
Score = 72.0 bits (175), Expect = 5e-12
Identities = 76/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 1515 VVYRDEAHYRDEE-NLEIFPVDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADLDG 1572
V + + Y D+ N + V L+K+ G G ++G ++I I+ GAA+ DG
Sbjct: 707 VYLKSKTLYEDKPPNTKDLDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDG 765
Query: 1573 RLIQGDQILSVNGEDMRNASQETVATILKCA--QGLVQLEIGRLRAGSWTSARTTSQNSQ 1630
RL D+++ ++G ++ S + V ++ A G V L + R +
Sbjct: 766 RLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR-------------KIFY 812
Query: 1631 GSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGIS 1690
G +Q S + QN G+ R++ EP V + R+ ++ G
Sbjct: 813 GEKQPEDDS-----SQAFISTQN--GSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865
Query: 1691 IAGGRGSPL-GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
I + P G IP I + A R KLKVGD I ++NGQ + LSH ++V L+K+
Sbjct: 866 ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925
Query: 1750 AYGRIILQVVAD---------TNISAIAAQLENMSTGYHLGSPTAEHHPED 1791
A + L V+A+ TN + + L++ +G A H P D
Sbjct: 926 AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP----MGQSQANHIPGD 972
Score = 67.0 bits (162), Expect = 2e-10
Identities = 66/240 (27%), Positives = 110/240 (45%), Gaps = 44/240 (18%)
Query: 249 VELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQ 308
+ LI G GF I T G V+ I+ LQ GD I +I NVQ +T Q
Sbjct: 579 IPLIKGPKGFGFAIADSPT-GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQ 634
Query: 309 VAQVLRN--CGNSVRMLVAR-----------------DPAGDI-SVTPPAPAALPVALPT 348
V +VL+ G V +L+ R + AG + ++ P P +P
Sbjct: 635 VVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSI 694
Query: 349 VASKGPGSDSS--------LFE-----TYNVEL-VRKDGQSLGIRIVGYVGTSHTGEASG 394
+ S P D S L+E T ++++ +RK G R++G G +
Sbjct: 695 IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS----- 749
Query: 395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTL-VRRK 453
IY+ +IIP AA +G ++ D+++ +DG+ ++G ++ V++++ A + H+ L VRRK
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Score = 66.2 bits (160), Expect = 3e-10
Identities = 81/375 (21%), Positives = 150/375 (40%), Gaps = 69/375 (18%)
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
R G GF V+ + I++ + P A++D RL+ D+++ I+ P+ + S
Sbjct: 730 RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPV-KGKS 785
Query: 199 HQQAIALLQQTT--GSLRLIVAREPVH--------------TKSSTSSSLNDTTLPETVC 242
H+Q + L+ G + L V R+ + + + S LN +P
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 243 WGHVEEVELIN-DGSGLGFGIVGGKTS---GVV---VRTIVPGGLADRDGRLQTGDHILK 295
+V L + G GF I+ K GV+ + ++ G ADR G+L+ GDHI
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD------PAGDISV-TPPAPAALPVALPT 348
+ G ++ ++ + + Q++++ G +V + V + P+G S PA P+ +
Sbjct: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMG-QS 964
Query: 349 VASKGPGSDSSLFETYNVELVRKDGQSLG---------IRIVGYVGTSHTGEAS------ 393
A+ PG S+L ++ S ++ VG+ H
Sbjct: 965 QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024
Query: 394 -------------------GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDV 434
G+++ + A +G I V D+IV ++G QG +
Sbjct: 1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRA 1084
Query: 435 VEVLRNAGQVVHLTL 449
+E+++ G V L L
Sbjct: 1085 IELIQAGGNKVLLLL 1099
Score = 54.3 bits (129), Expect = 1e-06
Identities = 66/258 (25%), Positives = 100/258 (38%), Gaps = 63/258 (24%)
Query: 146 GFSVVALRSQNL---GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQA 202
GF V L S+N G + + V GS ADR +LK D I A+N + + +SH
Sbjct: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE-LSHDNI 919
Query: 203 IALLQQTTGSLRLIVARE------PVHTKSSTSS-------------------------- 230
+ L++ ++ L V E P T S+ S
Sbjct: 920 VQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979
Query: 231 -------------------SLNDTTLPETVCWGHVEE-----VELINDGSGLGFGIVGGK 266
+ DT + V H + VEL G GF + GGK
Sbjct: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGK 1039
Query: 267 --TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV 324
G+ + + G A +DGR+ GD I++I G QG+T + ++++ GN V +L+
Sbjct: 1040 EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV-LLL 1098
Query: 325 ARDPAGDISVTPPAPAAL 342
R G I AP+ L
Sbjct: 1099 LRPGTGLIPDHGLAPSGL 1116
Score = 52.4 bits (124), Expect = 4e-06
Identities = 58/279 (20%), Positives = 106/279 (37%), Gaps = 37/279 (13%)
Query: 1231 ADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
+ L G L L+K G G ++ G DR + V + +GPAA DG++ GD +++I
Sbjct: 402 SQLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDI 460
Query: 1291 NNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTE 1350
N + G +H + + + P VN +P+P S + D
Sbjct: 461 NGNCVLGHTHADVVQMFQLVPV---------NQYVNLTLCRGYPLPDDSEDPVVDIVAAT 511
Query: 1351 PISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDAD 1410
P+ + + S+ G + + FK ++Q S H+ D
Sbjct: 512 PVINGQ--SLTKG-ETCMNPQDFKPGAMVLEQN-----------------GKSGHTLTGD 551
Query: 1411 FTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEE 1470
+ V A+ + + I + KG G G +I +++ + +
Sbjct: 552 GLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ 611
Query: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTP 1509
G L GD I E+ +++N +H + + L+Q P
Sbjct: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 10/89 (11%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
VE+ R P G S+ GG+ E G+FI ++ ED PA K + GD+I+E+
Sbjct: 1022 VELERGPR-GFGFSLRGGK---------EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
+G Q +H+ A+E I+ GN V+ +++
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
Score = 47.4 bits (111), Expect = 1e-04
Identities = 120/566 (21%), Positives = 201/566 (35%), Gaps = 124/566 (21%)
Query: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV-- 312
G GF I+GG + V+ ++ G A +DG++ GD I+ I G V G T V Q+
Sbjct: 419 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Query: 313 LRNCGNSVRMLVAR---------DPAGDISVTPPA-------------------PAALPV 344
L V + + R DP DI P P A+ +
Sbjct: 479 LVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVL 538
Query: 345 --------ALPTVASKGP-----------GSDSSLFETYNVELVRKDGQSLGIRIVGY-V 384
L GP S SS E + L++ G + G+ +
Sbjct: 539 EQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIK------GPKGFGFAI 592
Query: 385 GTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRN--AG 442
S TG+ VK I+ + + G +Q D I + N+Q + VVEVL+ G
Sbjct: 593 ADSPTGQK----VKMIL--DSQWCQG-LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVG 645
Query: 443 QVVHLTLVRRKTSSSTSPLEPPSDR-------GTVVEPLKPPALFLTGAVET-ETNVDGE 494
V L ++R S T + +D+ + EP+ P F + + +D
Sbjct: 646 ADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPS 705
Query: 495 DEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDA 554
+ +K + TL D + L+ E+ R GPD +
Sbjct: 706 EVYLKSK--TLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSI------------- 750
Query: 555 ELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYG 614
YI +I+ G + G L+ DEL+ ++G+ + G
Sbjct: 751 ---------------------------YIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
Query: 615 KSRREAVSFLKEVP--PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED 672
KS ++ + + L R++F E ++ ++S + +
Sbjct: 784 KSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPED----DSSQAFISTQNGSPRLNRAE 839
Query: 673 DDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLL 732
A P +V K+ +G GF IL ++ P I ++ A+R G L
Sbjct: 840 VPARPAPQEP-YDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLK 898
Query: 733 PGDRLVSVNEYCLDNTSLAEAVEILK 758
GD + +VN + S V+++K
Sbjct: 899 VGDHISAVNGQSIVELSHDNIVQLIK 924
Score = 46.6 bits (109), Expect = 2e-04
Identities = 28/94 (29%), Positives = 53/94 (56%), Gaps = 7/94 (7%)
Query: 689 LVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNT 748
L K G GF+I+ P + + +++++ DG A + G + PGD +V +N C+
Sbjct: 413 LKKSTMGFGFTIIGGDRPDE----FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 749 SLAEAVEILKAVPPG-LVHLGICK--PLVEDNEE 779
+ A+ V++ + VP V+L +C+ PL +D+E+
Sbjct: 469 THADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499
+ K G G +I+GG D P + + V ++G AA+DG++ GD I+++NG + +H
Sbjct: 413 LKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 1500 EAITALRQTP--QKVRLVVYR 1518
+ + + P Q V L + R
Sbjct: 472 DVVQMFQLVPVNQYVNLTLCR 492
Score = 38.9 bits (89), Expect = 0.046
Identities = 42/215 (19%), Positives = 80/215 (37%), Gaps = 40/215 (18%)
Query: 581 HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE--VPPPFTLVCCRR 638
H I ++ G P D G L+ D + VNG + S V +K+ V T++
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 639 LFDDEASVDEPRRT------------------ETSLPETEVDHNMDVNTEEDDDGELALW 680
+ + R++ + S E E+ ++ + L
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 681 SPEVKI----------------VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGV 724
P+ + VEL + +G GFS+ + + + ++R L DG
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 725 AERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
A + G + GD++V +N + A+E+++A
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQA 1090
Score = 37.7 bits (86), Expect = 0.10
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
+++ER G GFS+ + N+G +F+ + A +D R+ DQI+ IN P
Sbjct: 1022 VELER-GPRGFGFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEP-T 1076
Query: 195 QNISHQQAIALLQQTTGSLRLIV 217
Q I+H +AI L+Q + L++
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Score = 36.6 bits (83), Expect = 0.23
Identities = 55/264 (20%), Positives = 96/264 (36%), Gaps = 54/264 (20%)
Query: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP--FTLVCCRR-- 638
+ +++ GP G + P D ++++NG + G + + V + VP L CR
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYP 495
Query: 639 LFDDEAS--VDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWS--------------- 681
L DD VD T ++ +N ++ G + L
Sbjct: 496 LPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNG 555
Query: 682 ------------------PEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADG 723
PE+ + L+K KG GF+I D PT + ++ D
Sbjct: 556 PSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD-----SPTGQKV---KMILD- 606
Query: 724 VAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCY 783
++ GL GD + + + N + + VE+LK P +G PL+
Sbjct: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP-----VGADVPLLILRGGPPSP 660
Query: 784 ILHSSSNEDKTEFSGTIHDINSSL 807
+ DK E +G++ IN +
Sbjct: 661 TKTAKMKTDKKENAGSLEAINEPI 684
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 113 bits (283), Expect = 1e-24
Identities = 194/835 (23%), Positives = 301/835 (36%), Gaps = 158/835 (18%)
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP------ 628
D D I S+V GP G ++ D ++ VN + G + + V + +P
Sbjct: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
Query: 629 ---------------PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED- 672
P +LV + D E + + T S P + VN +D
Sbjct: 550 LELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS-PASHSSKTGKVNGMKDA 608
Query: 673 ------------------DDGELA---LWSPEVKIVELVKDCKGLGFSILDYQDPLDPTR 711
D LA PE+ V +VK G GF+I D P
Sbjct: 609 RPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIAD-----SPGG 663
Query: 712 SVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPG-----LVH 766
++ +V + R GL GD +V VN+ + + + V++L P G LV
Sbjct: 664 GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 767 LG---------ICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRD 817
G +PL + + S HS S+ + H ++ ++ E P
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSLHTASPSH--STQVLPEFPPAEAQ 776
Query: 818 EPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWE---MHEFLTPRLQEMDEEREMLVDE 874
P + D G+ K QS+ +E M L + + ERE+
Sbjct: 777 AP----DQTDSS----GQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREI---- 824
Query: 875 EYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQE 934
S + P+ QE E FG + L NEP G +Y
Sbjct: 825 -------NSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEP--------GEPIYIGH 869
Query: 935 AQPYGYCPENVM----KENFVMESLPSVPSTEGN----SQQGRFDDLENLNSLAKTSLDL 986
P G + E ++ P + + QQ NL K +
Sbjct: 870 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV 929
Query: 987 GMIPNDVQGP-SLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCE 1045
N+V P S A E++ P + +S S T + S
Sbjct: 930 PKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS-------- 981
Query: 1046 LPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIK 1105
G G + S P VEI R N G IV + R + G +
Sbjct: 982 ------GGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSS---VSRPEAGTTFGNACVA 1032
Query: 1106 ------QVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVF--IVQ 1157
+++E SPA + LK GD+IL V+G + N SHS+ V IK AGN V I
Sbjct: 1033 MPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1092
Query: 1158 SLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEE 1217
SS ++ N A T + +Q+ ++ + T P + +KA +E
Sbjct: 1093 DESSNATLLTNAEKIATITT--THTPSQQGTQETRNTTKPKQESQFEFKA----PQATQE 1146
Query: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAA 1277
+D +T +ELE+ G G SL G ++ + M ++V+ + +GPA
Sbjct: 1147 QDFYT-----------------VELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAER 1188
Query: 1278 DGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTP 1332
G+MRIGDE+LEIN + H A +IK +V+L R + +V + A+ P
Sbjct: 1189 CGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP 1243
Score = 93.6 bits (231), Expect = 2e-18
Identities = 110/450 (24%), Positives = 189/450 (42%), Gaps = 94/450 (20%)
Query: 224 TKSSTSSSLNDTTLPETVCWGHVEE-VELINDGSGLGFGIVGGKTSG--VVVRTIVPGGL 280
+K +N T E + E+ + L +G GF I+GG G + + IVP G
Sbjct: 816 SKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGA 875
Query: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS--VRMLVARD-----PAGDIS 333
AD DGRL++GD ++ + GT V G + + V Q+++ V + V R P +
Sbjct: 876 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
Query: 334 VTPPA--------PAALPV----------ALPTVASK-------------GPGSDSSLFE 362
V PA PA+L +L TV+S G G S++ +
Sbjct: 936 VPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
Query: 363 TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIY-------VKSIIPGSAAYHNGHIQVN 415
Y+VE+ R + + G IV V G G + II GS A G ++V
Sbjct: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055
Query: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK 475
D+I+AV+G +I ++ D+V +++ AG V L ++ SS+
Sbjct: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN------------------ 1097
Query: 476 PPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLL 535
A LT A E+I T+ + + + ++ ++ + + +S++E
Sbjct: 1098 --ATLLTNA---------------EKIATITTTHTPSQQGTQETRNTTKPKQESQFE--- 1137
Query: 536 GPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTL 595
++ AT + Q EL++ +K +LR G E ++ Y+ + GP +
Sbjct: 1138 ---FKAPQATQE-QDFYTVELERGAKGFGF-SLRGGRE---YNMDLYVLRLAEDGPAERC 1189
Query: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
G ++ DE+LE+NG A+ +K
Sbjct: 1190 GKMRIGDEILEINGETTKNMKHSRAIELIK 1219
Score = 89.4 bits (220), Expect = 3e-17
Identities = 138/611 (22%), Positives = 228/611 (37%), Gaps = 148/611 (24%)
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA--GNPVVFIVQSLS- 1160
+KQ++ DSP + LK GD I+EV+ ++Q +H++ V+ + G+ V +VQ
Sbjct: 668 VKQIV-DSP--RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
Query: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAP----------PPMKLPPPYKALTD 1210
P+ P K + N +Q + +P PP + P + TD
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ--TD 782
Query: 1211 DSDENEEEDAFTDQKIRQRYADLP-----------------------GELHI-------I 1240
S + + + + R Y + P GE I I
Sbjct: 783 SSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDI 842
Query: 1241 ELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSH 1300
L + + G G + G + I++ I P G A DGR+R GDEL+ ++ + G+SH
Sbjct: 843 FLWRKETGFGFRILGGNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 1301 QNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
Q +++ A + + V + T VPS + S S +P S E+
Sbjct: 902 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSH---HSSNQPASLTEE--- 955
Query: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
K+ P+ SQ +S ST +G GG
Sbjct: 956 ----KRTPQG----------------------SQNSLNTVSSGSGSTSGIGSGGGGGSGV 989
Query: 1421 LSVDPATCPIVPGQEMIIEISKGRS-GLGLSIVGGKDTPL------NAIV-----IHEVY 1468
+S +V Q +EI +G + G G IV P NA V I +
Sbjct: 990 VST------VV--QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRII 1041
Query: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY----------- 1517
E A R G+L GD+IL VNG + N SH + + +++ V L +
Sbjct: 1042 EGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLL 1101
Query: 1518 -----------------------RDEAHYRDEENLEI-----------FPVDLQKKAGRG 1543
R+ + E E + V+L++ A +G
Sbjct: 1102 TNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA-KG 1160
Query: 1544 LGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
G S+ G R +++ + + G A+ G++ GD+IL +NGE +N ++K
Sbjct: 1161 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
Query: 1603 AQGLVQLEIGR 1613
V+L + R
Sbjct: 1221 GGRRVRLFLKR 1231
Score = 85.9 bits (211), Expect = 3e-16
Identities = 77/246 (31%), Positives = 111/246 (45%), Gaps = 34/246 (13%)
Query: 1543 GLGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
G G I+G G ++I IV GAAD DGRL GD+++ V+G + S + V +++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 1602 CA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP----VITGLQNLV 1655
A QG V L + R + T S HSS P+ G QN +
Sbjct: 910 QAAKQGHVNLTVRRKVV---FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 966
Query: 1656 GTKRVSDPSQKNSG-------------TDMEPRTVEINRELSDALGISIAGG-----RGS 1697
T VS S SG T ++P VEI R ++ G I G+
Sbjct: 967 NT--VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024
Query: 1698 PLGD----IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGR 1753
G+ +P I I A R KLKVGDRI+++NG + SH+D+VNL+K A
Sbjct: 1025 TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
Query: 1754 IILQVV 1759
+ L+++
Sbjct: 1085 VTLRII 1090
Score = 85.1 bits (209), Expect = 6e-16
Identities = 173/851 (20%), Positives = 314/851 (36%), Gaps = 132/851 (15%)
Query: 1007 QRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPERE---EGEGEETPNFSHW 1063
Q+++Q+ Q Q SA + + E P RE +G+ T N S
Sbjct: 408 QQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPE-PAREVPLQGKPFFTRNPSEL 466
Query: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
I R+ + G ++VGG + L+ IK ++ D PA ++TGD
Sbjct: 467 KGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQ---------IKSLVLDGPAALDGKMETGD 517
Query: 1124 KILEVSGVDLQNASHSEAVEAIKNA------------GNPVVFIVQSLSSTPRVIPNVHN 1171
I+ V+ + +H++ V+ ++ G P+ F +++ + +
Sbjct: 518 VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILD 577
Query: 1172 KANKIT-GNQNQDTQEKKEKRQGTAPPPMKLPPPYKA-LTDDSDENEEEDAFTDQKIRQR 1229
K I G + D+ + G P A + +S D + +
Sbjct: 578 KEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVS---LASS 634
Query: 1230 YADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLE 1289
A P EL + + K G G ++A + + + +P ++ GD ++E
Sbjct: 635 IATQP-ELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG-----LKEGDLIVE 688
Query: 1290 INNQILYGRSHQNASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQS 1347
+N + + +H ++ P S+V L+ R V P P S P +D
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPV------PKKSPKSQPLERKDSQ 742
Query: 1348 GTEPISSEEDGSVEVG--------IKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLA 1399
+ S S+ + + P +E+ + QK P +Q +
Sbjct: 743 NSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMY 802
Query: 1400 PASSYHSTDADFTGYGGFQAPL-SVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTP 1458
+ A G + + S + CPI QE I + + +G G I+GG + P
Sbjct: 803 ENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNE-P 861
Query: 1459 LNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK--VRLVV 1516
I I + GAA DGRL +GD+++ V+G + SH+ + ++Q ++ V L V
Sbjct: 862 GEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 921
Query: 1517 YRDEAHYRDEENLEI-----------FPVDL--QKKAGRGLGLSIVGKRNGSGVFISDIV 1563
R + E+ P L +K+ +G S+ +GSG S I
Sbjct: 922 RRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSG-STSGIG 980
Query: 1564 K--GGAADLDGRLIQGDQILSVNGED-------MRNASQETVATILKCAQGLVQLEIGRL 1614
GG + + ++Q + GE+ + + S+ T A + +IGR+
Sbjct: 981 SGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRI 1040
Query: 1615 RAGS--------WTSARTTSQNSQGSQQSAHSSC-------------------HPSFAPV 1647
GS R + N +HS S A +
Sbjct: 1041 IEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATL 1100
Query: 1648 ITGLQNLV--------------GTKRVSDPSQKNSGTDMEPR--------TVEINRELSD 1685
+T + + T+ + P Q++ P+ TVE+ R +
Sbjct: 1101 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AK 1159
Query: 1686 ALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
G S+ GGR ++ +++ + G A R K+++GD I+ ING+ + H+ +
Sbjct: 1160 GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1216
Query: 1746 LLKNAYGRIIL 1756
L+KN R+ L
Sbjct: 1217 LIKNGGRRVRL 1227
Score = 73.2 bits (178), Expect = 2e-12
Identities = 89/430 (20%), Positives = 162/430 (37%), Gaps = 93/430 (21%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
G GF ++ N I++ + P AD D RL+ D+++ ++ TP+ SHQ +
Sbjct: 850 GFGFRILG---GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905
Query: 204 ALLQQTT--GSLRLIVAREPVHTKSST-------SSSLNDTTLPETVC------WGHVEE 248
L+QQ G + L V R+ V T +SS + + P ++ G
Sbjct: 906 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS 965
Query: 249 VELINDGSGL--GFGIVGGKTSGVV----------------------------------- 271
+ ++ GSG G G GG SGVV
Sbjct: 966 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 1025
Query: 272 -----------VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV 320
+ I+ G ADR G+L+ GD IL + G ++ + + +++ GN+V
Sbjct: 1026 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
Query: 321 RM-LVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ----- 374
+ ++ D + + ++ A + T+ + S ET N +++ Q
Sbjct: 1086 TLRIIPGDESSNATLLTNAEK-----IATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
Query: 375 --------------SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
G + G+ +YV + A G +++ D+I+
Sbjct: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
Query: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV-VEPLKPPAL 479
++G + + +E+++N G+ V L L R S + PP+ + E L
Sbjct: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
Query: 480 FLTGAVETET 489
+L G +T T
Sbjct: 1261 YLMGHNQTTT 1270
Score = 69.7 bits (169), Expect = 2e-11
Identities = 100/495 (20%), Positives = 189/495 (38%), Gaps = 103/495 (20%)
Query: 1051 EGEGEETPNFSHWGPPRIVEIFREPNVSL-------GISIVGGQTVIKRLKNGEELKGIF 1103
+GE E N +++G I + ++E ++ L G I+GG E + I+
Sbjct: 817 KGEREREINSTNFGECPIPD-YQEQDIFLWRKETGFGFRILGGN---------EPGEPIY 866
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163
I ++ A L++GD+++ V G + SH V+ ++ A +
Sbjct: 867 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV 926
Query: 1164 RVIPNVHNK-----ANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEE 1218
+P N+ ++ + NQ E+K QG+ + T
Sbjct: 927 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS-LNTVSSGSGSTSGIGSGGGG 985
Query: 1219 DAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSRMSIFV----------V 1267
+ + Q Y +E+ + +N G G + + R +
Sbjct: 986 GSGVVSTVVQPYD--------VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKI 1037
Query: 1268 GINPEG-PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVN 1326
G EG PA G++++GD +L +N + +SH + +IK A + V L I +++ N
Sbjct: 1038 GRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN 1097
Query: 1327 QMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESES-FKLAVSQMKQQKY 1385
+T ++ + + T + + G+ E P+ ES F+ Q Q++
Sbjct: 1098 ATLLT---------NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ- 1147
Query: 1386 PTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS 1445
DF +E+ +G
Sbjct: 1148 ------------------------DF------------------------YTVELERGAK 1159
Query: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
G G S+ GG++ ++ V+ + E+G A R G++ GD+ILE+NG +N H AI +
Sbjct: 1160 GFGFSLRGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
Query: 1506 RQTPQKVRLVVYRDE 1520
+ ++VRL + R +
Sbjct: 1219 KNGGRRVRLFLKRGD 1233
Score = 63.5 bits (153), Expect = 2e-09
Identities = 70/259 (27%), Positives = 110/259 (42%), Gaps = 51/259 (19%)
Query: 135 IDIERPSTGGLGFSVVALRSQ-----NLGKVDIFVKD----VQPGSVADRDQRLKENDQI 185
++I R G GF +V+ S+ G + + + GS ADR +LK D+I
Sbjct: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
Query: 186 LAINHTPLDQNISHQQAIALLQQ--TTGSLRLIVARE-----------------PVHTKS 226
LA+N + N SH + L+++ T +LR+I E HT S
Sbjct: 1059 LAVNGCSI-TNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
Query: 227 --STSSSLNDT----------TLPETVCWGHVEEVELINDGSGLGFGIVGGK--TSGVVV 272
T + N T P+ VEL G GF + GG+ + V
Sbjct: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1177
Query: 273 RTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI 332
+ G A+R G+++ GD IL+I G + M + ++++N G VR+ + R GD
Sbjct: 1178 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR---GDG 1234
Query: 333 SVTPPAPAALPVALPTVAS 351
SV P A +P P +A+
Sbjct: 1235 SV--PEYAMIP---PNIAA 1248
Score = 51.2 bits (121), Expect = 9e-06
Identities = 35/109 (32%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 688 ELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
+L K +G GF+++ +P + + I+SLV DG A G + GD +VSVN+ C+
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 748 TSLAEAVEILKAVPPGL-VHLGICK--PLVEDNEEESCYILHSSSNEDK 793
+ A+ V+I +++P G V L +C+ PL D ++ + ++ S + DK
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK 578
Score = 43.5 bits (101), Expect = 0.002
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 64 LNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVI 123
L IP D S+N LL + T H PS T PK ++ F
Sbjct: 1087 LRIIPGDESSNAT-----LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ-FEFKA 1140
Query: 124 QQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKEND 183
Q Q + +++ER + G GFS+ R N+ D++V + A+R +++ D
Sbjct: 1141 PQATQEQDFYTVELERGAKG-FGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGD 1196
Query: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+IL IN +N+ H +AI L++ +RL + R
Sbjct: 1197 EILEIN-GETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
Score = 41.6 bits (96), Expect = 0.007
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 4/87 (4%)
Query: 244 GHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNV 301
G +L G GF +VGG + ++++V G A DG+++TGD I+ + T V
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 302 QGMTSEQVAQVLRN--CGNSVRMLVAR 326
G T QV ++ ++ G SV + + R
Sbjct: 528 LGHTHAQVVKIFQSIPIGASVDLELCR 554
Score = 37.4 bits (85), Expect = 0.13
Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 249 VELINDGSGLGFGIV---GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
V ++ G GF I GG G V+ IV + R L+ GD I+++ NVQ +T
Sbjct: 644 VHIVKGPMGFGFTIADSPGG--GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALT 698
Query: 306 SEQVAQVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPV 344
QV +L C G+ V +LV R G + V +P + P+
Sbjct: 699 HNQVVDMLVECPKGSEVTLLVQR---GGLPVPKKSPKSQPL 736
>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
Length = 1076
Score = 112 bits (279), Expect = 4e-24
Identities = 166/751 (22%), Positives = 299/751 (39%), Gaps = 142/751 (18%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+VE+ ++ +LG+++ GG K+G+ + + + A +++ L GD I
Sbjct: 53 VVELMKKEGTTLGLTVSGGID-----KDGKPR----VSNLRQGGIAARSDQLDVGDYIKA 103
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQ------SLSSTPRVIPNV----HNKANK-- 1175
V+G++L H E + +KN G VV V+ S+ + + V H + N
Sbjct: 104 VNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFG 163
Query: 1176 --ITGNQNQDTQEKKE------------KRQGTAPPPMKL----------PPPYKALTDD 1211
I G + D + + R+GT P +L +A++
Sbjct: 164 FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
Query: 1212 SDENEEEDAFT--DQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGI 1269
+E D + A G L + + LG++L + ++ I + I
Sbjct: 224 KQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKI 283
Query: 1270 NPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED---AVN 1326
A G + +GD +L I+ + + A+ + +VKL + + A+
Sbjct: 284 KSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALK 343
Query: 1327 QMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYP 1386
S SP+S+ S +SS G++ + S + ++K++ +
Sbjct: 344 GPDHAALVSSSFSPTSMSAYS----LSSLNMGTLPRSLYST--SPRGTMMRRRLKKKDFK 397
Query: 1387 TKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSG 1446
+ +S +S + LA + T + L+ DP T G
Sbjct: 398 SSLSLASSTVGLAGQVVHTETT---------EVVLTADPVT------------------G 430
Query: 1447 LGLSIVGG---KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAIT 1503
G+ + G +T + +I + + A R G L GD+++ +NG+ +S+ EEA
Sbjct: 431 FGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ 490
Query: 1504 ALRQTP--QKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVG---KRNGSGVF 1558
LR + KV L + D A + F V L KK LG++I ++ G +
Sbjct: 491 LLRDSSITSKVTLEIEFDVAESVIPSS-GTFHVKLPKKHNVELGITISSPSSRKPGDPLV 549
Query: 1559 ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGS 1618
ISDI KG A G L GD++L+++ + N S E IL+ + LV+L+I
Sbjct: 550 ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI------- 602
Query: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVE 1678
R NS Q++SG + TVE
Sbjct: 603 ----RKDEDNSD---------------------------------EQESSGAII--YTVE 623
Query: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738
+ R LGI+I+G P P+ I+ + G+A RT + +GDRI++IN L G
Sbjct: 624 LKR-YGGPLGITISGTE-EPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGK 679
Query: 1739 SHADVVNLLKNAYGRIILQVVADTNISAIAA 1769
++ ++LL+ A + L++ T+ + ++
Sbjct: 680 PLSEAIHLLQMAGETVTLKIKKQTDAQSASS 710
Score = 104 bits (259), Expect = 9e-22
Identities = 146/628 (23%), Positives = 244/628 (38%), Gaps = 107/628 (17%)
Query: 164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH 223
V +++ G +A R +L D I A+N L + H + I+LL+ + L V E
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAK-FRHDEIISLLKNVGERVVLEVEYELPP 138
Query: 224 TKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGG------KTSGVVVRTIVP 277
SS + T EV L +G+ GF I GG K+ VV+ + P
Sbjct: 139 VSVQGSSVIFRTV-----------EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRP 187
Query: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPP 337
GG ADR+G ++ GD +L + G + G T + +L+ CG +L+ D+SV
Sbjct: 188 GGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEY----DVSVMDS 243
Query: 338 APAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYV 397
A GP VE+ + G SLG+ + TS I +
Sbjct: 244 VATA----------SGP---------LLVEVAKTPGASLGVALT----TSMCCNKQVIVI 280
Query: 398 KSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
I S A G + V D I+++DG +++ + + L N V L ++ +
Sbjct: 281 DKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPH--HQT 338
Query: 458 TSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLE 517
L+ P V P ++ + + + +L+
Sbjct: 339 RLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGT------LPRSLYSTSPRGTMMRRRLK 392
Query: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVE---- 573
K L S L G +V T T++ A+ P+ + ++
Sbjct: 393 KKDFKSSLSLASSTVGLAGQ----VVHTETTEVVLTAD--------PVTGFGIQLQGSVF 440
Query: 574 -VDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT 632
++ IS I + P + G+LQ D ++ +NG+ + EA L++ +
Sbjct: 441 ATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRD-----S 495
Query: 633 LVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKD 692
+ + + E V E+ +P + G + P+ VEL
Sbjct: 496 SITSKVTLEIEFDV-----AESVIPSS---------------GTFHVKLPKKHNVEL--- 532
Query: 693 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752
G+ S + P DP +VI + VA R+G L GD+L++++ LDN S+ +
Sbjct: 533 --GITISSPSSRKPGDP----LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMED 586
Query: 753 AVEILKAVPPGLVHLGICKPLVEDNEEE 780
AV+IL+ LV L I K EDN +E
Sbjct: 587 AVQILQQC-EDLVKLKIRKD--EDNSDE 611
Score = 87.4 bits (215), Expect = 1e-16
Identities = 127/606 (20%), Positives = 231/606 (38%), Gaps = 105/606 (17%)
Query: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
+ + V+PG ADR+ +K D++L+++ L +H +A+++L+Q L++ +
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRL-LGTTHAEAMSILKQCGQEAALLIEYDV 238
Query: 222 VHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG---VVVRTIVPG 278
S ++S G + G+ LG + +V+ I
Sbjct: 239 SVMDSVATAS------------GPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSA 286
Query: 279 GLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPA 338
+ADR G L GDHIL I GT+++ T + Q L N + V++ + +++ P
Sbjct: 287 SIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPD 346
Query: 339 PAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVK 398
AAL SS F ++ ++G TS G +K
Sbjct: 347 HAALV--------------SSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLK 392
Query: 399 SI-IPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
S + + + + ++V + + A+ ++ G V + S
Sbjct: 393 KKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLIS 452
Query: 458 TSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLE 517
+ P++R V++ + V + ED +E L++ +I + LE
Sbjct: 453 YIEADSPAERCGVLQ--------IGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 504
Query: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSF 577
D E+ + S + KL H + LG+ + S
Sbjct: 505 IEFDVAESVIPSSGTF-------------------------HVKLPKKHNVELGITISSP 539
Query: 578 DGHH-----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT 632
IS I G G L+ D+LL ++ ++L S +AV L++
Sbjct: 540 SSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQ------ 593
Query: 633 LVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKD 692
C L + DE D + E++ G + + VEL +
Sbjct: 594 ---CEDLVKLKIRKDE-----------------DNSDEQESSGAI------IYTVELKRY 627
Query: 693 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752
LG +I ++P DP I+I SL G+AER+G + GDR++++N L L+E
Sbjct: 628 GGPLGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
Query: 753 AVEILK 758
A+ +L+
Sbjct: 684 AIHLLQ 689
Score = 82.0 bits (201), Expect = 5e-15
Identities = 64/224 (28%), Positives = 109/224 (48%), Gaps = 24/224 (10%)
Query: 1458 PLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY 1517
P + +VI ++ + A R G L GD++L ++ + L N S E+A+ L+Q V+L +
Sbjct: 544 PGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIR 603
Query: 1518 RDEAHYRDEEN--LEIFPVDLQKKAGRGLGLSIVGKRNG-SGVFISDIVKGGAADLDGRL 1574
+DE + ++E+ I+ V+L K+ G LG++I G + IS + KGG A+ G +
Sbjct: 604 KDEDNSDEQESSGAIIYTVEL-KRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAI 662
Query: 1575 IQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQ 1634
GD+IL++N ++ +L+ A V L+I + Q
Sbjct: 663 HIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKK-------------------QT 703
Query: 1635 SAHSSCHPSFAPVITGLQNLVGTKRVSDPSQK-NSGTDMEPRTV 1677
A S+ P P+ + L +L + S P+QK +DM P TV
Sbjct: 704 DAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
Score = 79.0 bits (193), Expect = 4e-14
Identities = 104/418 (24%), Positives = 175/418 (41%), Gaps = 49/418 (11%)
Query: 1416 GFQAPLSVDPATCPI-VPGQEMI---IEISKGRSG--LGLSIVGGKDTPLNA---IVIHE 1466
G + L V+ P+ V G +I +E++ + G G I GG N +VI
Sbjct: 125 GERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
Query: 1467 VYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDE 1526
V G A R+G + GD++L V+G+ L ++H EA++ L+Q Q+ L++ D + D
Sbjct: 185 VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS-VMDS 243
Query: 1527 ENLEIFP--VDLQKKAGRGLGLSIVGKR--NGSGVFISDIVKGGAADLDGRLIQGDQILS 1582
P V++ K G LG+++ N + I I AD G L GD ILS
Sbjct: 244 VATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILS 303
Query: 1583 VNGEDMRNASQETVATILKCAQGLVQLEI-----GRLRAGSWTSARTTSQNSQGSQQSAH 1637
++G M + L V+LEI RL A S + + SA+
Sbjct: 304 IDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAY 363
Query: 1638 SSCHPSFAPVITGLQNLV--GT---KRVSDPSQKNS-----------GTDMEPRTVEI-- 1679
S + + L + GT +R+ K+S G + T E+
Sbjct: 364 SLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVL 423
Query: 1680 NRELSDALGISIAGGR-GSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738
+ GI + G + P I+ I+A A R L++GDR+++ING P +
Sbjct: 424 TADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDS 483
Query: 1739 SHADVVNLLKNA--YGRIILQVVADTNISAIAA---------QLENMSTGYHLGSPTA 1785
+ + LL+++ ++ L++ D S I + + N+ G + SP++
Sbjct: 484 TFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSS 541
Score = 72.4 bits (176), Expect = 4e-12
Identities = 93/420 (22%), Positives = 176/420 (41%), Gaps = 62/420 (14%)
Query: 77 FSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQ----------QM 126
FS + ++ S+ G + R +++ G +L +DF S + Q+
Sbjct: 355 FSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTM-MRRRLKKKDFKSSLSLASSTVGLAGQV 413
Query: 127 AQGRQIEYIDIERPSTG-GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQI 185
E + P TG G+ ++ L + + ++ S A+R L+ D++
Sbjct: 414 VHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRV 472
Query: 186 LAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGH 245
+AIN P + + + ++A LL+ ++ + ++ + E + ++ +P + + H
Sbjct: 473 MAINGIPTEDS-TFEEASQLLRDSSITSKVTLEIE---------FDVAESVIPSSGTF-H 521
Query: 246 VEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQG 303
V+ + N G+ + G +V+ I G +A R G L+ GD +L I +
Sbjct: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
Query: 304 MTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFET 363
+ E Q+L+ C + V++ + +D +SS
Sbjct: 582 CSMEDAVQILQQCEDLVKLKIRKDE----------------------DNSDEQESSGAII 619
Query: 364 YNVELVRKDGQSLGIRIVGYVGTSHTGEA-SGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
Y VEL R G LGI I G T E I + S+ G A G I + D+I+A++
Sbjct: 620 YTVELKRYGGP-LGITISG------TEEPFDPIIISSLTKGGLAERTGAIHIGDRILAIN 672
Query: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRR-KTSSSTSPLEPP-----SDRGTVVEPLKP 476
+++G + + +L+ AG+ V L + ++ S++SP + P SD G V E P
Sbjct: 673 SSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSP 732
Score = 65.9 bits (159), Expect = 3e-10
Identities = 81/339 (23%), Positives = 139/339 (41%), Gaps = 67/339 (19%)
Query: 1433 GQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492
G ++ + K + LGL++ GG D V + + + G AAR +L GD I VNG++
Sbjct: 50 GSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSN-LRQGGIAARSDQLDVGDYIKAVNGIN 108
Query: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIF---PVDLQKKAGRGLGLSIV 1549
L H+E I+ L+ ++V L V + + + IF V L K+ G G I
Sbjct: 109 LAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKE-GNTFGFVIR 167
Query: 1550 G-----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK-CA 1603
G + V I+ + GG AD +G + GD++LSV+G + + +ILK C
Sbjct: 168 GGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCG 227
Query: 1604 QG---LVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRV 1660
Q L++ ++ V
Sbjct: 228 QEAALLIEYDVS-----------------------------------------------V 240
Query: 1661 SDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQK 1720
D SG P VE+ + +LG+++ + I I+++ +A R
Sbjct: 241 MDSVATASG----PLLVEVAKTPGASLGVALT--TSMCCNKQVIVIDKIKSASIADRCGA 294
Query: 1721 LKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
L VGD I+SI+G ++ + A+ L N ++ L+++
Sbjct: 295 LHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL 333
Score = 58.2 bits (139), Expect = 7e-08
Identities = 96/490 (19%), Positives = 186/490 (37%), Gaps = 79/490 (16%)
Query: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
P +VE+ + P SLG+++ K++ I I ++ S A + AL GD I
Sbjct: 250 PLLVEVAKTPGASLGVALTTSMCCNKQV--------IVIDKIKSASIADRCGALHVGDHI 301
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKA--NKITGNQNQD 1183
L + G ++ + +EA + + N + V + T + + A + +
Sbjct: 302 LSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMS 361
Query: 1184 TQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL------ 1237
GT P + P + +++D + + L G++
Sbjct: 362 AYSLSSLNMGTLPRSLYSTSPRGTMM--RRRLKKKDFKSSLSLASSTVGLAGQVVHTETT 419
Query: 1238 HIIELEKDKNGLGLSLAGN---KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294
++ G G+ L G+ + + I + PA G ++IGD ++ IN
Sbjct: 420 EVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP 479
Query: 1295 LYGRSHQNASAIIK----TAPSKVKLVFIRNEDAVNQMAVTPFPVPS----------SSP 1340
+ + AS +++ T+ +++ F E + +P SSP
Sbjct: 480 TEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSP 539
Query: 1341 SSIEDQSGTEPISSE--------EDGSVEVGIKQLP------ESESFKLAVSQMKQQKYP 1386
SS + G + S+ G++E+G K L ++ S + AV ++Q +
Sbjct: 540 SS--RKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDL 597
Query: 1387 TKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSG 1446
K+ E +S + + +G I+ +E+ +
Sbjct: 598 VKLKIRKDE--------DNSDEQESSG---------------AII----YTVELKRYGGP 630
Query: 1447 LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALR 1506
LG++I G + P + I+I + + G A R G + GD+IL +N L+ EAI L+
Sbjct: 631 LGITI-SGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ 689
Query: 1507 QTPQKVRLVV 1516
+ V L +
Sbjct: 690 MAGETVTLKI 699
Score = 53.9 bits (128), Expect = 1e-06
Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 74/281 (26%)
Query: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
V++ ++ NV LGI+I + K G+ L I + + S A +T L+ GDK+L +
Sbjct: 522 VKLPKKHNVELGITISSPSS----RKPGDPL---VISDIKKGSVAHRTGTLELGDKLLAI 574
Query: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKK 1188
+ L N S +AV+ ++ Q +D + K
Sbjct: 575 DNIRLDNCSMEDAVQILQ---------------------------------QCEDLVKLK 601
Query: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248
++ D+SDE E A ++ +EL++
Sbjct: 602 IRKD----------------EDNSDEQESSGAI---------------IYTVELKRYGGP 630
Query: 1249 LGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308
LG++++G ++ I + + G A G + IGD +L IN+ L G+ A +++
Sbjct: 631 LGITISGTEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ 689
Query: 1309 TAPSKVKLVFIRNEDAVNQMAVTPFPVPS--SSPSSIEDQS 1347
A V L + DA + + FP+ S S +E+ S
Sbjct: 690 MAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDS 730
Score = 52.4 bits (124), Expect = 4e-06
Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 8/104 (7%)
Query: 1655 VGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGV 1714
+ +R S P + T VE+ ++ LG++++GG D ++ ++ G+
Sbjct: 37 LAVRRQSIPEEFKGST-----VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGI 88
Query: 1715 AARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
AAR+ +L VGD I ++NG L H ++++LLKN R++L+V
Sbjct: 89 AARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV 132
Score = 49.3 bits (116), Expect = 3e-05
Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
S T P AL V ++ + GS VEL++K+G +LG+ + G G G+
Sbjct: 28 SQTKPPDGALAVRRQSIPEEFKGSTV-------VELMKKEGTTLGLTVSG--GIDKDGKP 78
Query: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447
V ++ G A + + V D I AV+G+N+ F + +++ +L+N G+ V L
Sbjct: 79 R---VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVL 130
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 15/124 (12%)
Query: 1224 QKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRI 1283
Q+I++ + P ELH + L KD + + ++V I P GP G ++
Sbjct: 937 QEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKP 995
Query: 1284 GDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
D LL++N+ +I + +K+ LV RN P +S SI
Sbjct: 996 YDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN--------------PLASQKSI 1041
Query: 1344 EDQS 1347
+ QS
Sbjct: 1042 DQQS 1045
Score = 32.7 bits (73), Expect = 3.3
Identities = 20/77 (25%), Positives = 36/77 (46%), Gaps = 2/77 (2%)
Query: 253 NDGSGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
+D GF + G GV V+ I P G D G L+ D +L++ + V
Sbjct: 959 SDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVP 1017
Query: 312 VLRNCGNSVRMLVARDP 328
++ GN + ++++R+P
Sbjct: 1018 LIAESGNKLDLVISRNP 1034
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 111 bits (277), Expect = 7e-24
Identities = 194/829 (23%), Positives = 298/829 (35%), Gaps = 159/829 (19%)
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP------ 628
D D I S+V GP G ++ D ++ VN + G + + V + +P
Sbjct: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
Query: 629 ---------------PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED- 672
P +LV + D E + + T S P + VN +D
Sbjct: 550 LELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS-PASHSSKTGKVNGMKDA 608
Query: 673 ------------------DDGELA---LWSPEVKIVELVKDCKGLGFSILDYQDPLDPTR 711
D LA PE+ V +VK G GF+I D P
Sbjct: 609 RPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIAD-----SPGG 663
Query: 712 SVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPG-----LVH 766
++ +V + R GL GD +V VN+ + + + V++L P G LV
Sbjct: 664 GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 767 LG---------ICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRD 817
G +PL + + S HS S+ + H ++ ++ E P
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSLHTASPSH--STQVLPEFPPAEAQ 776
Query: 818 EPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWE---MHEFLTPRLQEMDEEREMLVDE 874
P + D G+ K QS+ +E M L + + ERE+
Sbjct: 777 AP----DQTDSS----GQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREI---- 824
Query: 875 EYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQE 934
S + P+ QE E FG + L NEP G +Y
Sbjct: 825 -------NSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEP--------GEPIYIGH 869
Query: 935 AQPYGYCPENVM----KENFVMESLPSVPSTEGN----SQQGRFDDLENLNSLAKTSLDL 986
P G + E ++ P + + QQ NL K +
Sbjct: 870 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV 929
Query: 987 GMIPNDVQGP-SLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCE 1045
N+V P S A E++ P + +S S T + S
Sbjct: 930 PKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS-------- 981
Query: 1046 LPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIF-- 1103
G G + S P VEI R N G IV + R + G G
Sbjct: 982 ------GGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSS---VSRPEAGTTFAGNACV 1032
Query: 1104 -----IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--FIV 1156
I +++E SPA + LK GD+IL V+G + N SHS+ V IK AGN V I
Sbjct: 1033 AMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP 1092
Query: 1157 QSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENE 1216
SS ++ N A T + +Q+ ++ + T P + +KA +
Sbjct: 1093 GDESSNATLLTNAEKIATITT--THTPSQQGTQETRNTTKPKQESQFEFKA----PQATQ 1146
Query: 1217 EEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAA 1276
E+D +T +ELE+ G G SL G ++ + M ++V+ + +GPA
Sbjct: 1147 EQDFYT-----------------VELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAE 1188
Query: 1277 ADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAV 1325
G+MRIGDE+LEIN + H A +IK +V+L R + +V
Sbjct: 1189 RCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1237
Score = 94.0 bits (232), Expect = 1e-18
Identities = 112/451 (24%), Positives = 192/451 (42%), Gaps = 95/451 (21%)
Query: 224 TKSSTSSSLNDTTLPETVCWGHVEE-VELINDGSGLGFGIVGGKTSG--VVVRTIVPGGL 280
+K +N T E + E+ + L +G GF I+GG G + + IVP G
Sbjct: 816 SKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGA 875
Query: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS--VRMLVARD-----PAGDIS 333
AD DGRL++GD ++ + GT V G + + V Q+++ V + V R P +
Sbjct: 876 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
Query: 334 VTPPA--------PAALPV----------ALPTVASK-------------GPGSDSSLFE 362
V PA PA+L +L TV+S G G S++ +
Sbjct: 936 VPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
Query: 363 TYNVELVRKDGQSLGIRIVGYV-----GTSHTGEASGIY---VKSIIPGSAAYHNGHIQV 414
Y+VE+ R + + G IV V GT+ G A + II GS A G ++V
Sbjct: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKV 1055
Query: 415 NDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPL 474
D+I+AV+G +I ++ D+V +++ AG V L ++ SS+
Sbjct: 1056 GDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN----------------- 1098
Query: 475 KPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENL 534
A LT A E+I T+ + + + ++ ++ + + +S++E
Sbjct: 1099 ---ATLLTNA---------------EKIATITTTHTPSQQGTQETRNTTKPKQESQFE-- 1138
Query: 535 LGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDT 594
++ AT + Q EL++ +K +LR G E ++ Y+ + GP +
Sbjct: 1139 ----FKAPQATQE-QDFYTVELERGAKGFGF-SLRGGRE---YNMDLYVLRLAEDGPAER 1189
Query: 595 LGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
G ++ DE+LE+NG A+ +K
Sbjct: 1190 CGKMRIGDEILEINGETTKNMKHSRAIELIK 1220
Score = 89.0 bits (219), Expect = 4e-17
Identities = 137/610 (22%), Positives = 226/610 (37%), Gaps = 145/610 (23%)
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA--GNPVVFIVQSLS- 1160
+KQ++ DSP + LK GD I+EV+ ++Q +H++ V+ + G+ V +VQ
Sbjct: 668 VKQIV-DSP--RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
Query: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAP----------PPMKLPPPYKALTD 1210
P+ P K + N +Q + +P PP + P + TD
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ--TD 782
Query: 1211 DSDENEEEDAFTDQKIRQRYADLP-----------------------GELHI-------I 1240
S + + + + R Y + P GE I I
Sbjct: 783 SSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDI 842
Query: 1241 ELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSH 1300
L + + G G + G + I++ I P G A DGR+R GDEL+ ++ + G+SH
Sbjct: 843 FLWRKETGFGFRILGGNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 1301 QNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
Q +++ A + + V + T VPS + S S +P S E+
Sbjct: 902 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS---HHSSNQPASLTEE--- 955
Query: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
K+ P+ SQ +S ST +G GG
Sbjct: 956 ----KRTPQ----------------------GSQNSLNTVSSGSGSTSGIGSGGGGGSGV 989
Query: 1421 LS--VDPATCPIVPGQE----MIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYE 1469
+S V P I G+ +I S R G + G NA V I + E
Sbjct: 990 VSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAG------NACVAMPHKIGRIIE 1043
Query: 1470 EGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY------------ 1517
A R G+L GD+IL VNG + N SH + + +++ V L +
Sbjct: 1044 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLT 1103
Query: 1518 ----------------------RDEAHYRDEENLE-----------IFPVDLQKKAGRGL 1544
R+ + E E + V+L++ A +G
Sbjct: 1104 NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA-KGF 1162
Query: 1545 GLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
G S+ G R +++ + + G A+ G++ GD+IL +NGE +N ++K
Sbjct: 1163 GFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG 1222
Query: 1604 QGLVQLEIGR 1613
V+L + R
Sbjct: 1223 GRRVRLFLKR 1232
Score = 84.7 bits (208), Expect = 7e-16
Identities = 76/247 (30%), Positives = 108/247 (43%), Gaps = 35/247 (14%)
Query: 1543 GLGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
G G I+G G ++I IV GAAD DGRL GD+++ V+G + S + V +++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 1602 CA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP----VITGLQNLV 1655
A QG V L + R + T S HSS P+ G QN +
Sbjct: 910 QAAKQGHVNLTVRRKVV---FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 966
Query: 1656 GTKRVSDPSQKNSG-------------TDMEPRTVEINRELSDALGISIAGGRGSPLGD- 1701
T VS S SG T ++P VEI R ++ G I P
Sbjct: 967 NT--VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024
Query: 1702 ---------IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYG 1752
+P I I A R KLKVGDRI+++NG + SH+D+VNL+K A
Sbjct: 1025 TFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1084
Query: 1753 RIILQVV 1759
+ L+++
Sbjct: 1085 TVTLRII 1091
Score = 72.0 bits (175), Expect = 5e-12
Identities = 102/506 (20%), Positives = 194/506 (38%), Gaps = 93/506 (18%)
Query: 1051 EGEGEETPNFSHWGPPRIVEIFREPNVSL-------GISIVGGQTVIKRLKNGEELKGIF 1103
+GE E N +++G I + ++E ++ L G I+GG E + I+
Sbjct: 817 KGEREREINSTNFGECPIPD-YQEQDIFLWRKETGFGFRILGGN---------EPGEPIY 866
Query: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163
I ++ A L++GD+++ V G + SH V+ ++ A +
Sbjct: 867 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV 926
Query: 1164 RVIPNVHNK-----ANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEE 1218
+P N+ ++ + NQ E+K QG+ + + +
Sbjct: 927 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGG 986
Query: 1219 DAFTDQKIRQ-----RYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEG 1273
++ R + G +I + G + AGN + M + I
Sbjct: 987 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVA-MPHKIGRIIEGS 1045
Query: 1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPF 1333
PA G++++GD +L +N + +SH + +IK A + V L I +++ N +T
Sbjct: 1046 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLT-- 1103
Query: 1334 PVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESES-FKLAVSQMKQQKYPTKVSFS 1392
++ + + T + + G+ E P+ ES F+ Q Q++
Sbjct: 1104 -------NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ-------- 1148
Query: 1393 SQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIV 1452
DF +E+ +G G G S+
Sbjct: 1149 -----------------DF------------------------YTVELERGAKGFGFSLR 1167
Query: 1453 GGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1512
GG++ ++ V+ + E+G A R G++ GD+ILE+NG +N H AI ++ ++V
Sbjct: 1168 GGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1226
Query: 1513 RLVVYRDEAHY-----RDEENLEIFP 1533
RL + R + + EN+ FP
Sbjct: 1227 RLFLKRGDGSVPEYGGSNYENIPSFP 1252
Score = 71.6 bits (174), Expect = 6e-12
Identities = 56/203 (27%), Positives = 95/203 (46%), Gaps = 17/203 (8%)
Query: 1559 ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGS 1618
I I++G AD G+L GD+IL+VNG + N S + ++K A V L R+ G
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL---RIIPGD 1094
Query: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQ-----KNSGTDME 1673
+S T N++ ++ + P G Q T + SQ + + +
Sbjct: 1095 ESSNATLLTNAEKI-----ATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD 1149
Query: 1674 PRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733
TVE+ R + G S+ GGR ++ +++ + G A R K+++GD I+ ING+
Sbjct: 1150 FYTVELERG-AKGFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGE 1205
Query: 1734 PLDGLSHADVVNLLKNAYGRIIL 1756
+ H+ + L+KN R+ L
Sbjct: 1206 TTKNMKHSRAIELIKNGGRRVRL 1228
Score = 69.3 bits (168), Expect = 3e-11
Identities = 80/392 (20%), Positives = 148/392 (37%), Gaps = 93/392 (23%)
Query: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
G GF ++ N I++ + P AD D RL+ D+++ ++ TP+ SHQ +
Sbjct: 850 GFGFRILG---GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905
Query: 204 ALLQQTT--GSLRLIVAREPVHTKSST-------SSSLNDTTLPETVC------WGHVEE 248
L+QQ G + L V R+ V T +SS + + P ++ G
Sbjct: 906 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS 965
Query: 249 VELINDGSGL--GFGIVGGKTSGVV----------------------------------- 271
+ ++ GSG G G GG SGVV
Sbjct: 966 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 1025
Query: 272 ------------VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS 319
+ I+ G ADR G+L+ GD IL + G ++ + + +++ GN+
Sbjct: 1026 FAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1085
Query: 320 VRM-LVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ---- 374
V + ++ D + + ++ A + T+ + S ET N +++ Q
Sbjct: 1086 VTLRIIPGDESSNATLLTNAEK-----IATITTTHTPSQQGTQETRNTTKPKQESQFEFK 1140
Query: 375 ---------------SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
G + G+ +YV + A G +++ D+I+
Sbjct: 1141 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1200
Query: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
++G + + +E+++N G+ V L L R
Sbjct: 1201 EINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
Score = 60.8 bits (146), Expect = 1e-08
Identities = 64/243 (26%), Positives = 100/243 (41%), Gaps = 47/243 (19%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIF----------VKDVQPGSVADRDQRLKENDQ 184
++I R G GF +V+ S+ + + GS ADR +LK D+
Sbjct: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1058
Query: 185 ILAINHTPLDQNISHQQAIALLQQT--TGSLRLIVAREP-----------------VHTK 225
ILA+N + N SH + L+++ T +LR+I E HT
Sbjct: 1059 ILAVNGCSIT-NKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1117
Query: 226 SS--TSSSLNDTT----------LPETVCWGHVEEVELINDGSGLGFGIVGGK--TSGVV 271
S T + N T P+ VEL G GF + GG+ +
Sbjct: 1118 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1177
Query: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGD 331
V + G A+R G+++ GD IL+I G + M + ++++N G VR+ + R GD
Sbjct: 1178 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR---GD 1234
Query: 332 ISV 334
SV
Sbjct: 1235 GSV 1237
Score = 60.5 bits (145), Expect = 1e-08
Identities = 81/352 (23%), Positives = 134/352 (38%), Gaps = 61/352 (17%)
Query: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI 1239
Q Q T+E E PP + PP + + FT + ++L G+
Sbjct: 418 QQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFT-----RNPSELKGKFIH 472
Query: 1240 IELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRS 1299
+L K G G ++ G + + + + +GPAA DG+M GD ++ +N+ + G +
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531
Query: 1300 HQNASAIIKTAP--SKVKLVFIR------NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
H I ++ P + V L R + D N VT + P + +G E
Sbjct: 532 HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIV---NGQET 588
Query: 1352 ISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADF 1411
S S + G KV+ P +PA ++
Sbjct: 589 YDSPASHSSKTG------------------------KVNGMKDARPSSPADVASNSS--- 621
Query: 1412 TGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIV---GGKDTPLNAIVIHEVY 1468
GY L+ AT P + + + I KG G G +I GG + IV
Sbjct: 622 HGYPNDTVSLASSIATQP----ELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV----- 672
Query: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ--KVRLVVYR 1518
+ R L GD I+EVN +++ +H + + L + P+ +V L+V R
Sbjct: 673 ---DSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQR 721
Score = 51.2 bits (121), Expect = 9e-06
Identities = 35/109 (32%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 688 ELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
+L K +G GF+++ +P + + I+SLV DG A G + GD +VSVN+ C+
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 748 TSLAEAVEILKAVPPGL-VHLGICK--PLVEDNEEESCYILHSSSNEDK 793
+ A+ V+I +++P G V L +C+ PL D ++ + ++ S + DK
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK 578
Score = 43.5 bits (101), Expect = 0.002
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 64 LNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVI 123
L IP D S+N LL + T H PS T PK ++ F
Sbjct: 1088 LRIIPGDESSNAT-----LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ-FEFKA 1141
Query: 124 QQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKEND 183
Q Q + +++ER + G GFS+ R N+ D++V + A+R +++ D
Sbjct: 1142 PQATQEQDFYTVELERGAKG-FGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGD 1197
Query: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+IL IN +N+ H +AI L++ +RL + R
Sbjct: 1198 EILEIN-GETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
Score = 41.6 bits (96), Expect = 0.007
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 4/87 (4%)
Query: 244 GHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNV 301
G +L G GF +VGG + ++++V G A DG+++TGD I+ + T V
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 302 QGMTSEQVAQVLRN--CGNSVRMLVAR 326
G T QV ++ ++ G SV + + R
Sbjct: 528 LGHTHAQVVKIFQSIPIGASVDLELCR 554
Score = 37.7 bits (86), Expect = 0.10
Identities = 58/238 (24%), Positives = 96/238 (40%), Gaps = 35/238 (14%)
Query: 1538 KKAGRGLGLSIVGKRNGSGVF-ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
+K+ RG G ++VG I +V G A LDG++ GD I+SVN + T
Sbjct: 476 RKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG---HTH 532
Query: 1597 ATILKCAQGL-----VQLEIGR----------LRAGSWTSARTTSQNS---QGSQQSAHS 1638
A ++K Q + V LE+ R TS + G +
Sbjct: 533 AQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSP 592
Query: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQ--KNSGTDMEPRTVEINRELS---DALGISIAG 1693
+ H S + G+++ R S P+ NS TV + ++ + + + I
Sbjct: 593 ASHSSKTGKVNGMKD----ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVK 648
Query: 1694 GR---GSPLGDIPVFIAM-IQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLL 1747
G G + D P ++ + R + LK GD IV +N + + L+H VV++L
Sbjct: 649 GPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDML 706
Score = 37.4 bits (85), Expect = 0.13
Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 249 VELINDGSGLGFGIV---GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
V ++ G GF I GG G V+ IV + R L+ GD I+++ NVQ +T
Sbjct: 644 VHIVKGPMGFGFTIADSPGG--GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALT 698
Query: 306 SEQVAQVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPV 344
QV +L C G+ V +LV R G + V +P + P+
Sbjct: 699 HNQVVDMLVECPKGSEVTLLVQR---GGLPVPKKSPKSQPL 736
Score = 32.3 bits (72), Expect = 4.3
Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 1681 RELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSH 1740
R+ S G ++ GG D + I + G AA K++ GD IVS+N + G +H
Sbjct: 476 RKSSRGFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTH 532
Query: 1741 ADVVNLLKN 1749
A VV + ++
Sbjct: 533 AQVVKIFQS 541
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 110 bits (276), Expect = 9e-24
Identities = 179/784 (22%), Positives = 306/784 (39%), Gaps = 170/784 (21%)
Query: 1045 ELPEREEGEGEETPNFSHW-----GPPRIVEIFR----EPNVSLGISIVGGQTVIKRLKN 1095
+ P++E T N ++ PP+ +IF + + SLGIS+ GG V +++
Sbjct: 1144 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGG--VNTSVRH 1201
Query: 1096 GEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFI 1155
G GI++K V+ A + GD++L V+GV L+ A+H +AVE ++N G VV +
Sbjct: 1202 G----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1256
Query: 1156 VQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDEN 1215
+ +P +V +QN QG P +K K + ++EN
Sbjct: 1257 LLEKGQSPTSKEHVPVTPQCTLSDQN---------AQGQGPEKVKKTTQVKDYSFVTEEN 1307
Query: 1216 EEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA--GNKDRSRMSIFVVGIN--- 1270
E ++L K+ +GLG S + N +++ +V +
Sbjct: 1308 TFE---------------------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLF 1346
Query: 1271 PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAV 1330
P PAA G++ +GD +L++N L G S Q + ++ +V L+ R V
Sbjct: 1347 PGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1406
Query: 1331 TPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT-KV 1389
T P SP+ + +S +D S ++Q S+ +++ KQ K P+ +
Sbjct: 1407 TALLTPLQSPAQVLP-------NSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1459
Query: 1390 SFS------SQEIPLAPA--------SSYHSTDADFT--GYGGFQAPLSVDPATCPI--- 1430
S+S ++ APA S+ H T ++ +AP S + C +
Sbjct: 1460 SYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYY 1519
Query: 1431 ---VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILE 1487
+P + + S L + G+ ++ E A++
Sbjct: 1520 PQKIPNKPEFED--SNPSPLPPDMAPGQS--------YQPQSESASS------------- 1556
Query: 1488 VNGVDLRNSSH-EEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
+ +D + H E TP K L E H D E + L K LG
Sbjct: 1557 -SSMDKYHIHHISEPTRQENWTPLKNDL-----ENHLEDFELEVELLITLIKSEKGSLGF 1610
Query: 1547 SIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGL 1606
++ G ++ D+++ A DGRL GD+++ VN D+ N + +L+ A
Sbjct: 1611 TVTKGNQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1669
Query: 1607 VQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQK 1666
V+L IGR+ P I L +L
Sbjct: 1670 VRLVIGRVLE----------------------------LPRIPMLPHL------------ 1689
Query: 1667 NSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDR 1726
+ T+ N+E LG S+ GG S L + V+I+ I VAA L++ D
Sbjct: 1690 -----LPDITLTCNKE---ELGFSLCGGHDS-LYQV-VYISDINPRSVAAIEGNLQLLDV 1739
Query: 1727 IVSINGQPLDGLSHADVVNLLKNAYGRIILQ-------VVADTNISAIAAQLENMSTG-Y 1778
I +NG G++ +V L + ++L+ VV + SA++A G Y
Sbjct: 1740 IHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSY 1799
Query: 1779 HLGS 1782
+GS
Sbjct: 1800 SVGS 1803
Score = 100 bits (248), Expect = 2e-20
Identities = 122/547 (22%), Positives = 221/547 (40%), Gaps = 85/547 (15%)
Query: 244 GHVEEVELINDGSGLGFGIVGG-----KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
G + EVEL + + LG + GG + G+ V+ ++P G A+ DGR+ GD +L + G
Sbjct: 1173 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1232
Query: 299 TNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDS 358
+++G T +Q + LRN G V +L+ + + P ++ +GP
Sbjct: 1233 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1292
Query: 359 SLFETYNVELVRKDGQSLGIRIV---GYVGTSHTGE---------ASGIYVKSIIPGSAA 406
+ + V ++ + +++ +G S + E AS + VK + PG A
Sbjct: 1293 KTTQVKDYSFVTEE-NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1351
Query: 407 YHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSD 466
+G I V D I+ V+G +++G + +V+ LR V L L R P P
Sbjct: 1352 AESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR------PPPGVLPEI 1405
Query: 467 RGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENE 526
++ PL+ PA L + + + ++ + +D + +K +K SP
Sbjct: 1406 DTALLTPLQSPAQVLPNSSKDSSQPSCVEQ-------STSSDENEMSDKSKKQCKSPSR- 1457
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
+ + + G + +V T I++ +S L H +S++
Sbjct: 1458 -RDSYSDSSGSGEDDLV-TAPANISNST----WSSAL----------------HQTLSNM 1495
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
VS ED + M Y + F P P L D A
Sbjct: 1496 VSQAQSHHEAPKSQEDTICT---MFYYPQKIPNKPEFEDSNPSP--------LPPDMAPG 1544
Query: 647 DEPRRTETSLPETEVD----HNMDVNTEEDD--------DGELALWSPEVKI-VELVKDC 693
+ S + +D H++ T +++ + L + EV++ + L+K
Sbjct: 1545 QSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSE 1604
Query: 694 KG-LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752
KG LGF++ R + ++ D A+ G L PGDRL+ VN+ + N + +
Sbjct: 1605 KGSLGFTVTKGNQ-----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1658
Query: 753 AVEILKA 759
AV +L+A
Sbjct: 1659 AVNLLRA 1665
Score = 87.0 bits (214), Expect = 1e-16
Identities = 81/291 (27%), Positives = 123/291 (42%), Gaps = 64/291 (21%)
Query: 351 SKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNG 410
S P +FE VEL + D SLGI + G V TS GIYVK++IP AA +G
Sbjct: 1166 SSSPPKPGDIFE---VELAKNDN-SLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDG 1219
Query: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470
I D+++AV+GV+++G + VE LRN GQVVHL L + ++ +S +
Sbjct: 1220 RIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV--------- 1270
Query: 471 VEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVP----DSPENE 526
P+ P ++ N G+ E ++ +K+ + E +V S
Sbjct: 1271 --PVTPQCTL------SDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF 1322
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
SR +NL+ +A + + KL P
Sbjct: 1323 SFSREDNLIPEQI-------------NASIVRVKKLFP---------------------- 1347
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
G P G + D +L+VNG L G S++E +S L+ P L+ CR
Sbjct: 1348 --GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1396
Score = 79.3 bits (194), Expect = 3e-14
Identities = 172/781 (22%), Positives = 289/781 (37%), Gaps = 134/781 (17%)
Query: 145 LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIA 204
LG SV + ++ I+VK V P A+ D R+ + D++LA+N L + +H+QA+
Sbjct: 1187 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL-EGATHKQAVE 1245
Query: 205 LLQQTTGSLRLIVAR-----EPVHTKSSTSSSLNDTTL----PET------------VCW 243
L+ T + L++ + H + +L+D PE V
Sbjct: 1246 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1305
Query: 244 GHVEEVELINDGSGLGF------GIVGGKTSGVVVRT--IVPGGLADRDGRLQTGDHILK 295
+ EV+L + SGLGF ++ + + +VR + PG A G++ GD ILK
Sbjct: 1306 ENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1365
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG 355
+ G +++G++ ++V LR V +L+ R P G V P AL L + A P
Sbjct: 1366 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG---VLPEIDTALLTPLQSPAQVLPN 1422
Query: 356 SDSSLFETYNVELVRKDGQS-----------LGIRIVGYVGTSHTGEASGIYVKSIIPGS 404
S + VE ++ R Y +S +GE + + I S
Sbjct: 1423 SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS 1482
Query: 405 AAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPP 464
H +++ + + + D + + Q + S+ SPL P
Sbjct: 1483 TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQ--KIPNKPEFEDSNPSPLPPD 1540
Query: 465 SDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPE 524
G +P E+ ++ + I + + +N L +
Sbjct: 1541 MAPGQSYQPQS----------ESASSSSMDKYHIHHISEPTRQENWTPL----------K 1580
Query: 525 NELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYIS 584
N+L++ E D+E+ V L T I +E + R+G Y+
Sbjct: 1581 NDLENHLE-----DFELEVELLITLI--KSEKGSLGFTVTKGNQRIGC---------YVH 1624
Query: 585 SIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEA 644
++ P + G L+P D L++VN + + +AV+ L+ LV R L
Sbjct: 1625 DVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVL----- 1678
Query: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQ 704
+ PR LP D + N EE LGFS+
Sbjct: 1679 --ELPR--IPMLPHLLPDITLTCNKEE------------------------LGFSLCGGH 1710
Query: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGL 764
D L V+ I + VA G L D + VN +L E L P L
Sbjct: 1711 DSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSL 1767
Query: 765 VHLGICKPL-VEDNEEESCYILHSSSNEDKTEFSGTIHD----INSSLILEAPKGFRDEP 819
V L V + + S S+ + + G+ N S A + +
Sbjct: 1768 VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEIS 1827
Query: 820 YFK-----EELVDEPFLDLGKSFHSQQKEI-EQSKEAWEMHEFLTPRLQEMDEEREMLVD 873
Y K ++ P L L K + Q+ +I + S+EA E + L +DEE + L++
Sbjct: 1828 YPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEA----EVIQSLLDVVDEEAQNLLN 1883
Query: 874 E 874
E
Sbjct: 1884 E 1884
Score = 64.7 bits (156), Expect = 8e-10
Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 3/100 (3%)
Query: 1236 ELHIIELEKD-KNGLGLSLAGNKDRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINN 1292
E+ ++ L+KD K GLG + G + R+ IF+ + P GPA DG ++ GD L+ +N+
Sbjct: 899 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 958
Query: 1293 QILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTP 1332
L G SH A I++ AP V LV + ++ ++++ TP
Sbjct: 959 VSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP 998
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 11/220 (5%)
Query: 1435 EMIIEISKGRSG-LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
E++I + K G LG ++ G +H+V ++ A + DGRL GD++++VN D+
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDV 1651
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
N +H +A+ LR + VRLV+ R R + P LG S+ G +
Sbjct: 1652 TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHD 1711
Query: 1554 G--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
V+ISDI A ++G L D I VNG + + E V L + + L+
Sbjct: 1712 SLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKA 1771
Query: 1612 GR----LRAGSWTSARTTSQNSQGSQQSAHSSC-HPSFAP 1646
R + S SA + ++++G+ + SC P+ P
Sbjct: 1772 TRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1811
Score = 61.6 bits (148), Expect = 7e-09
Identities = 85/400 (21%), Positives = 162/400 (40%), Gaps = 66/400 (16%)
Query: 369 VRKDGQ-SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
++KD + LG +I+G G GI++ S+ PG A +G ++ D++++V+ V+++
Sbjct: 905 LKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVET 487
G ++H +E+L+NA + V L + + K S P P + LT
Sbjct: 963 GVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP---------------VHLT----- 1002
Query: 488 ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLD 547
E+K + A++ K L+ EN GP + +L
Sbjct: 1003 --------NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLS 1054
Query: 548 TQIA--DDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELL 605
+Q + + A L + S++ LG + H G P ++ E E
Sbjct: 1055 SQDSRTESASLSQ-SQVNGFFASHLGDQTWQESQH--------GSPSPSVISKATEKETF 1105
Query: 606 EVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEV---D 662
+ K+++ +S + + + D D T +S + + +
Sbjct: 1106 TDSNQ---SKTKKPGISDVTD-------------YSDRGDSDMDEATYSSSQDHQTPKQE 1149
Query: 663 HNMDVNTEEDDDGELALWSP----EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRS 718
+ VNT + + SP ++ VEL K+ LG S+ + I +++
Sbjct: 1150 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN-TSVRHGGIYVKA 1208
Query: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
++ G AE G + GDR+++VN L+ + +AVE L+
Sbjct: 1209 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1248
Score = 57.8 bits (138), Expect = 9e-08
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 257 GLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
GLGF I+GG+ G + + ++ PGG AD DG L+ GD ++ + +++G++ +
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 312 VLRNCGNSVRMLVARDPAGDISVTPPAPAAL 342
+L+N V +++++ P IS P P L
Sbjct: 972 ILQNAPEDVTLVISQ-PKEKISKVPSTPVHL 1001
Score = 56.2 bits (134), Expect = 3e-07
Identities = 36/88 (40%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 1530 EIFPVDLQKKAGRGLGLSIVGK----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNG 1585
EI V+L+K A GLG I+G R G+FIS + GG ADLDG L GD+++SVN
Sbjct: 899 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 958
Query: 1586 EDMRNASQETVATILKCAQGLVQLEIGR 1613
+ S IL+ A V L I +
Sbjct: 959 VSLEGVSHHAAIEILQNAPEDVTLVISQ 986
Score = 55.8 bits (133), Expect = 4e-07
Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 5/92 (5%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVD--IFVKDVQPGSVADRDQRLKENDQILA 187
R+I +++++ + GLGF ++ + +G++D IF+ V PG AD D LK D++++
Sbjct: 898 REITLVNLKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 955
Query: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+N L + +SH AI +LQ + L++++
Sbjct: 956 VNSVSL-EGVSHHAAIEILQNAPEDVTLVISQ 986
Score = 55.5 bits (132), Expect = 5e-07
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+V + ++ LG I+GG+ K G GIFI V PA LK GD+++
Sbjct: 902 LVNLKKDAKYGLGFQIIGGE------KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 955
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
V+ V L+ SH A+E ++NA V ++ +P+
Sbjct: 956 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPS 996
Score = 52.0 bits (123), Expect = 5e-06
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 21/135 (15%)
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
L RW + P+ E+ + L DA+ +++ G ++ D +ISS+
Sbjct: 886 LHKRWSIVSSPEREITLVNLKK----DAKYGLGFQIIG------GEKMGRLDLGIFISSV 935
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
GGP D G L+P D L+ VN + L G S A+ L+ P TLV +
Sbjct: 936 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV-----------I 984
Query: 647 DEPRRTETSLPETEV 661
+P+ + +P T V
Sbjct: 985 SQPKEKISKVPSTPV 999
Score = 51.6 bits (122), Expect = 7e-06
Identities = 27/83 (32%), Positives = 43/83 (51%)
Query: 1668 SGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRI 1727
S + E V + ++ LG I GG D+ +FI+ + G A LK GDR+
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 1728 VSINGQPLDGLSHADVVNLLKNA 1750
+S+N L+G+SH + +L+NA
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNA 976
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/346 (21%), Positives = 134/346 (38%), Gaps = 39/346 (11%)
Query: 1446 GLGLSIVGGKDTPLN--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSH----- 1498
GLG I+GG+ I I V G A DG L GD+++ VN V L SH
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 1499 ------EEAITALRQTPQKVRLVV------------YRDEAHYRDEENLEIFPVDLQKKA 1540
E+ + Q +K+ V Y ++ Y + ++ D
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1031
Query: 1541 G--RGLGLSIVGKRNG--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQE-- 1594
G R + + G G G S + +A L + G S G+ SQ
Sbjct: 1032 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGF-FASHLGDQTWQESQHGS 1090
Query: 1595 -TVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQN 1653
+ + I K + + + + + T + +G ++ + S T Q
Sbjct: 1091 PSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEAT-YSSSQDHQTPKQE 1149
Query: 1654 LVGTKRVSDPSQKNSGTDMEPRTVEINR-ELS---DALGISIAGGRGSPLGDIPVFIAMI 1709
+ S+ + + P+ +I EL+ ++LGIS+ GG + + +++ +
Sbjct: 1150 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAV 1209
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRII 1755
G A ++ GDR++++NG L+G +H V L+N G+++
Sbjct: 1210 IPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVV 1254
Score = 50.4 bits (119), Expect = 2e-05
Identities = 33/80 (41%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 683 EVKIVELVKDCK-GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E+ +V L KD K GLGF I+ + + I I S+ G A+ G L PGDRL+SVN
Sbjct: 899 EITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 957
Query: 742 EYCLDNTSLAEAVEILKAVP 761
L+ S A+EIL+ P
Sbjct: 958 SVSLEGVSHHAAIEILQNAP 977
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 110 bits (276), Expect = 9e-24
Identities = 179/784 (22%), Positives = 306/784 (39%), Gaps = 170/784 (21%)
Query: 1045 ELPEREEGEGEETPNFSHW-----GPPRIVEIFR----EPNVSLGISIVGGQTVIKRLKN 1095
+ P++E T N ++ PP+ +IF + + SLGIS+ GG V +++
Sbjct: 1335 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGG--VNTSVRH 1392
Query: 1096 GEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFI 1155
G GI++K V+ A + GD++L V+GV L+ A+H +AVE ++N G VV +
Sbjct: 1393 G----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1447
Query: 1156 VQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDEN 1215
+ +P +V +QN QG P +K K + ++EN
Sbjct: 1448 LLEKGQSPTSKEHVPVTPQCTLSDQN---------AQGQGPEKVKKTTQVKDYSFVTEEN 1498
Query: 1216 EEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA--GNKDRSRMSIFVVGIN--- 1270
E ++L K+ +GLG S + N +++ +V +
Sbjct: 1499 TFE---------------------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLF 1537
Query: 1271 PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAV 1330
P PAA G++ +GD +L++N L G S Q + ++ +V L+ R V
Sbjct: 1538 PGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1597
Query: 1331 TPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT-KV 1389
T P SP+ + +S +D S ++Q S+ +++ KQ K P+ +
Sbjct: 1598 TALLTPLQSPAQVLP-------NSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1650
Query: 1390 SFS------SQEIPLAPA--------SSYHSTDADFT--GYGGFQAPLSVDPATCPI--- 1430
S+S ++ APA S+ H T ++ +AP S + C +
Sbjct: 1651 SYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYY 1710
Query: 1431 ---VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILE 1487
+P + + S L + G+ ++ E A++
Sbjct: 1711 PQKIPNKPEFED--SNPSPLPPDMAPGQS--------YQPQSESASS------------- 1747
Query: 1488 VNGVDLRNSSH-EEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
+ +D + H E TP K L E H D E + L K LG
Sbjct: 1748 -SSMDKYHIHHISEPTRQENWTPLKNDL-----ENHLEDFELEVELLITLIKSEKGSLGF 1801
Query: 1547 SIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGL 1606
++ G ++ D+++ A DGRL GD+++ VN D+ N + +L+ A
Sbjct: 1802 TVTKGNQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1860
Query: 1607 VQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQK 1666
V+L IGR+ P I L +L
Sbjct: 1861 VRLVIGRVLE----------------------------LPRIPMLPHL------------ 1880
Query: 1667 NSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDR 1726
+ T+ N+E LG S+ GG S L + V+I+ I VAA L++ D
Sbjct: 1881 -----LPDITLTCNKE---ELGFSLCGGHDS-LYQV-VYISDINPRSVAAIEGNLQLLDV 1930
Query: 1727 IVSINGQPLDGLSHADVVNLLKNAYGRIILQ-------VVADTNISAIAAQLENMSTG-Y 1778
I +NG G++ +V L + ++L+ VV + SA++A G Y
Sbjct: 1931 IHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSY 1990
Query: 1779 HLGS 1782
+GS
Sbjct: 1991 SVGS 1994
Score = 100 bits (248), Expect = 2e-20
Identities = 122/547 (22%), Positives = 221/547 (40%), Gaps = 85/547 (15%)
Query: 244 GHVEEVELINDGSGLGFGIVGG-----KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
G + EVEL + + LG + GG + G+ V+ ++P G A+ DGR+ GD +L + G
Sbjct: 1364 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1423
Query: 299 TNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDS 358
+++G T +Q + LRN G V +L+ + + P ++ +GP
Sbjct: 1424 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1483
Query: 359 SLFETYNVELVRKDGQSLGIRIV---GYVGTSHTGE---------ASGIYVKSIIPGSAA 406
+ + V ++ + +++ +G S + E AS + VK + PG A
Sbjct: 1484 KTTQVKDYSFVTEE-NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1542
Query: 407 YHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSD 466
+G I V D I+ V+G +++G + +V+ LR V L L R P P
Sbjct: 1543 AESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR------PPPGVLPEI 1596
Query: 467 RGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENE 526
++ PL+ PA L + + + ++ + +D + +K +K SP
Sbjct: 1597 DTALLTPLQSPAQVLPNSSKDSSQPSCVEQ-------STSSDENEMSDKSKKQCKSPSR- 1648
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
+ + + G + +V T I++ +S L H +S++
Sbjct: 1649 -RDSYSDSSGSGEDDLV-TAPANISNST----WSSAL----------------HQTLSNM 1686
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
VS ED + M Y + F P P L D A
Sbjct: 1687 VSQAQSHHEAPKSQEDTICT---MFYYPQKIPNKPEFEDSNPSP--------LPPDMAPG 1735
Query: 647 DEPRRTETSLPETEVD----HNMDVNTEEDD--------DGELALWSPEVKI-VELVKDC 693
+ S + +D H++ T +++ + L + EV++ + L+K
Sbjct: 1736 QSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSE 1795
Query: 694 KG-LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752
KG LGF++ R + ++ D A+ G L PGDRL+ VN+ + N + +
Sbjct: 1796 KGSLGFTVTKGNQ-----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1849
Query: 753 AVEILKA 759
AV +L+A
Sbjct: 1850 AVNLLRA 1856
Score = 87.0 bits (214), Expect = 1e-16
Identities = 81/291 (27%), Positives = 123/291 (42%), Gaps = 64/291 (21%)
Query: 351 SKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNG 410
S P +FE VEL + D SLGI + G V TS GIYVK++IP AA +G
Sbjct: 1357 SSSPPKPGDIFE---VELAKNDN-SLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDG 1410
Query: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470
I D+++AV+GV+++G + VE LRN GQVVHL L + ++ +S +
Sbjct: 1411 RIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV--------- 1461
Query: 471 VEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVP----DSPENE 526
P+ P ++ N G+ E ++ +K+ + E +V S
Sbjct: 1462 --PVTPQCTL------SDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF 1513
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
SR +NL+ +A + + KL P
Sbjct: 1514 SFSREDNLIPEQI-------------NASIVRVKKLFP---------------------- 1538
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
G P G + D +L+VNG L G S++E +S L+ P L+ CR
Sbjct: 1539 --GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1587
Score = 79.3 bits (194), Expect = 3e-14
Identities = 172/781 (22%), Positives = 289/781 (37%), Gaps = 134/781 (17%)
Query: 145 LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIA 204
LG SV + ++ I+VK V P A+ D R+ + D++LA+N L + +H+QA+
Sbjct: 1378 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL-EGATHKQAVE 1436
Query: 205 LLQQTTGSLRLIVAR-----EPVHTKSSTSSSLNDTTL----PET------------VCW 243
L+ T + L++ + H + +L+D PE V
Sbjct: 1437 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1496
Query: 244 GHVEEVELINDGSGLGF------GIVGGKTSGVVVRT--IVPGGLADRDGRLQTGDHILK 295
+ EV+L + SGLGF ++ + + +VR + PG A G++ GD ILK
Sbjct: 1497 ENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1556
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG 355
+ G +++G++ ++V LR V +L+ R P G V P AL L + A P
Sbjct: 1557 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG---VLPEIDTALLTPLQSPAQVLPN 1613
Query: 356 SDSSLFETYNVELVRKDGQS-----------LGIRIVGYVGTSHTGEASGIYVKSIIPGS 404
S + VE ++ R Y +S +GE + + I S
Sbjct: 1614 SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS 1673
Query: 405 AAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPP 464
H +++ + + + D + + Q + S+ SPL P
Sbjct: 1674 TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQ--KIPNKPEFEDSNPSPLPPD 1731
Query: 465 SDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPE 524
G +P E+ ++ + I + + +N L +
Sbjct: 1732 MAPGQSYQPQS----------ESASSSSMDKYHIHHISEPTRQENWTPL----------K 1771
Query: 525 NELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYIS 584
N+L++ E D+E+ V L T I +E + R+G Y+
Sbjct: 1772 NDLENHLE-----DFELEVELLITLI--KSEKGSLGFTVTKGNQRIGC---------YVH 1815
Query: 585 SIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEA 644
++ P + G L+P D L++VN + + +AV+ L+ LV R L
Sbjct: 1816 DVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVL----- 1869
Query: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQ 704
+ PR LP D + N EE LGFS+
Sbjct: 1870 --ELPR--IPMLPHLLPDITLTCNKEE------------------------LGFSLCGGH 1901
Query: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGL 764
D L V+ I + VA G L D + VN +L E L P L
Sbjct: 1902 DSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSL 1958
Query: 765 VHLGICKPL-VEDNEEESCYILHSSSNEDKTEFSGTIHD----INSSLILEAPKGFRDEP 819
V L V + + S S+ + + G+ N S A + +
Sbjct: 1959 VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEIS 2018
Query: 820 YFK-----EELVDEPFLDLGKSFHSQQKEI-EQSKEAWEMHEFLTPRLQEMDEEREMLVD 873
Y K ++ P L L K + Q+ +I + S+EA E + L +DEE + L++
Sbjct: 2019 YPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEA----EVIQSLLDVVDEEAQNLLN 2074
Query: 874 E 874
E
Sbjct: 2075 E 2075
Score = 64.7 bits (156), Expect = 8e-10
Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 3/100 (3%)
Query: 1236 ELHIIELEKD-KNGLGLSLAGNKDRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINN 1292
E+ ++ L+KD K GLG + G + R+ IF+ + P GPA DG ++ GD L+ +N+
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 1149
Query: 1293 QILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTP 1332
L G SH A I++ AP V LV + ++ ++++ TP
Sbjct: 1150 VSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP 1189
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 11/220 (5%)
Query: 1435 EMIIEISKGRSG-LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
E++I + K G LG ++ G +H+V ++ A + DGRL GD++++VN D+
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDV 1842
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
N +H +A+ LR + VRLV+ R R + P LG S+ G +
Sbjct: 1843 TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHD 1902
Query: 1554 G--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
V+ISDI A ++G L D I VNG + + E V L + + L+
Sbjct: 1903 SLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKA 1962
Query: 1612 GR----LRAGSWTSARTTSQNSQGSQQSAHSSC-HPSFAP 1646
R + S SA + ++++G+ + SC P+ P
Sbjct: 1963 TRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2002
Score = 61.6 bits (148), Expect = 7e-09
Identities = 85/400 (21%), Positives = 162/400 (40%), Gaps = 66/400 (16%)
Query: 369 VRKDGQ-SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
++KD + LG +I+G G GI++ S+ PG A +G ++ D++++V+ V+++
Sbjct: 1096 LKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVET 487
G ++H +E+L+NA + V L + + K S P P + LT
Sbjct: 1154 GVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP---------------VHLT----- 1193
Query: 488 ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLD 547
E+K + A++ K L+ EN GP + +L
Sbjct: 1194 --------NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLS 1245
Query: 548 TQIA--DDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELL 605
+Q + + A L + S++ LG + H G P ++ E E
Sbjct: 1246 SQDSRTESASLSQ-SQVNGFFASHLGDQTWQESQH--------GSPSPSVISKATEKETF 1296
Query: 606 EVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEV---D 662
+ K+++ +S + + + D D T +S + + +
Sbjct: 1297 TDSNQ---SKTKKPGISDVTD-------------YSDRGDSDMDEATYSSSQDHQTPKQE 1340
Query: 663 HNMDVNTEEDDDGELALWSP----EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRS 718
+ VNT + + SP ++ VEL K+ LG S+ + I +++
Sbjct: 1341 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN-TSVRHGGIYVKA 1399
Query: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
++ G AE G + GDR+++VN L+ + +AVE L+
Sbjct: 1400 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1439
Score = 57.8 bits (138), Expect = 9e-08
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 257 GLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
GLGF I+GG+ G + + ++ PGG AD DG L+ GD ++ + +++G++ +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 312 VLRNCGNSVRMLVARDPAGDISVTPPAPAAL 342
+L+N V +++++ P IS P P L
Sbjct: 1163 ILQNAPEDVTLVISQ-PKEKISKVPSTPVHL 1192
Score = 56.6 bits (135), Expect = 2e-07
Identities = 41/111 (36%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 1507 QTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK----RNGSGVFISDI 1562
Q P K V+++ + E EI V+L+K A GLG I+G R G+FIS +
Sbjct: 1068 QVPLKENDVLHKRWSIVSSPER-EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV 1126
Query: 1563 VKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
GG ADLDG L GD+++SVN + S IL+ A V L I +
Sbjct: 1127 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 55.8 bits (133), Expect = 4e-07
Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 5/92 (5%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVD--IFVKDVQPGSVADRDQRLKENDQILA 187
R+I +++++ + GLGF ++ + +G++D IF+ V PG AD D LK D++++
Sbjct: 1089 REITLVNLKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+N L + +SH AI +LQ + L++++
Sbjct: 1147 VNSVSL-EGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 55.5 bits (132), Expect = 5e-07
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+V + ++ LG I+GG+ K G GIFI V PA LK GD+++
Sbjct: 1093 LVNLKKDAKYGLGFQIIGGE------KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
V+ V L+ SH A+E ++NA V ++ +P+
Sbjct: 1147 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPS 1187
Score = 54.3 bits (129), Expect = 1e-06
Identities = 39/144 (27%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSF 577
+VP + L RW + P+ E+ + L DA+ +++ G ++
Sbjct: 1068 QVPLKENDVLHKRWSIVSSPEREITLVNLKK----DAKYGLGFQIIG------GEKMGRL 1117
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D +ISS+ GGP D G L+P D L+ VN + L G S A+ L+ P TLV
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV--- 1174
Query: 638 RLFDDEASVDEPRRTETSLPETEV 661
+ +P+ + +P T V
Sbjct: 1175 --------ISQPKEKISKVPSTPV 1190
Score = 51.6 bits (122), Expect = 7e-06
Identities = 27/83 (32%), Positives = 43/83 (51%)
Query: 1668 SGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRI 1727
S + E V + ++ LG I GG D+ +FI+ + G A LK GDR+
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 1728 VSINGQPLDGLSHADVVNLLKNA 1750
+S+N L+G+SH + +L+NA
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNA 1167
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/346 (21%), Positives = 134/346 (38%), Gaps = 39/346 (11%)
Query: 1446 GLGLSIVGGKDTPLN--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSH----- 1498
GLG I+GG+ I I V G A DG L GD+++ VN V L SH
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 1499 ------EEAITALRQTPQKVRLVV------------YRDEAHYRDEENLEIFPVDLQKKA 1540
E+ + Q +K+ V Y ++ Y + ++ D
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1222
Query: 1541 G--RGLGLSIVGKRNG--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQE-- 1594
G R + + G G G S + +A L + G S G+ SQ
Sbjct: 1223 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGF-FASHLGDQTWQESQHGS 1281
Query: 1595 -TVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQN 1653
+ + I K + + + + + T + +G ++ + S T Q
Sbjct: 1282 PSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEAT-YSSSQDHQTPKQE 1340
Query: 1654 LVGTKRVSDPSQKNSGTDMEPRTVEINR-ELS---DALGISIAGGRGSPLGDIPVFIAMI 1709
+ S+ + + P+ +I EL+ ++LGIS+ GG + + +++ +
Sbjct: 1341 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAV 1400
Query: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRII 1755
G A ++ GDR++++NG L+G +H V L+N G+++
Sbjct: 1401 IPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVV 1445
Score = 50.4 bits (119), Expect = 2e-05
Identities = 33/80 (41%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 683 EVKIVELVKDCK-GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E+ +V L KD K GLGF I+ + + I I S+ G A+ G L PGDRL+SVN
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148
Query: 742 EYCLDNTSLAEAVEILKAVP 761
L+ S A+EIL+ P
Sbjct: 1149 SVSLEGVSHHAAIEILQNAP 1168
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 110 bits (276), Expect = 9e-24
Identities = 179/784 (22%), Positives = 306/784 (39%), Gaps = 170/784 (21%)
Query: 1045 ELPEREEGEGEETPNFSHW-----GPPRIVEIFR----EPNVSLGISIVGGQTVIKRLKN 1095
+ P++E T N ++ PP+ +IF + + SLGIS+ GG V +++
Sbjct: 1316 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGG--VNTSVRH 1373
Query: 1096 GEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFI 1155
G GI++K V+ A + GD++L V+GV L+ A+H +AVE ++N G VV +
Sbjct: 1374 G----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1428
Query: 1156 VQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDEN 1215
+ +P +V +QN QG P +K K + ++EN
Sbjct: 1429 LLEKGQSPTSKEHVPVTPQCTLSDQN---------AQGQGPEKVKKTTQVKDYSFVTEEN 1479
Query: 1216 EEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA--GNKDRSRMSIFVVGIN--- 1270
E ++L K+ +GLG S + N +++ +V +
Sbjct: 1480 TFE---------------------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLF 1518
Query: 1271 PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAV 1330
P PAA G++ +GD +L++N L G S Q + ++ +V L+ R V
Sbjct: 1519 PGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1578
Query: 1331 TPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT-KV 1389
T P SP+ + +S +D S ++Q S+ +++ KQ K P+ +
Sbjct: 1579 TALLTPLQSPAQVLP-------NSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1631
Query: 1390 SFS------SQEIPLAPA--------SSYHSTDADFT--GYGGFQAPLSVDPATCPI--- 1430
S+S ++ APA S+ H T ++ +AP S + C +
Sbjct: 1632 SYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYY 1691
Query: 1431 ---VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILE 1487
+P + + S L + G+ ++ E A++
Sbjct: 1692 PQKIPNKPEFED--SNPSPLPPDMAPGQS--------YQPQSESASS------------- 1728
Query: 1488 VNGVDLRNSSH-EEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
+ +D + H E TP K L E H D E + L K LG
Sbjct: 1729 -SSMDKYHIHHISEPTRQENWTPLKNDL-----ENHLEDFELEVELLITLIKSEKGSLGF 1782
Query: 1547 SIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGL 1606
++ G ++ D+++ A DGRL GD+++ VN D+ N + +L+ A
Sbjct: 1783 TVTKGNQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1841
Query: 1607 VQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQK 1666
V+L IGR+ P I L +L
Sbjct: 1842 VRLVIGRVLE----------------------------LPRIPMLPHL------------ 1861
Query: 1667 NSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDR 1726
+ T+ N+E LG S+ GG S L + V+I+ I VAA L++ D
Sbjct: 1862 -----LPDITLTCNKE---ELGFSLCGGHDS-LYQV-VYISDINPRSVAAIEGNLQLLDV 1911
Query: 1727 IVSINGQPLDGLSHADVVNLLKNAYGRIILQ-------VVADTNISAIAAQLENMSTG-Y 1778
I +NG G++ +V L + ++L+ VV + SA++A G Y
Sbjct: 1912 IHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSY 1971
Query: 1779 HLGS 1782
+GS
Sbjct: 1972 SVGS 1975
Score = 100 bits (248), Expect = 2e-20
Identities = 122/547 (22%), Positives = 221/547 (40%), Gaps = 85/547 (15%)
Query: 244 GHVEEVELINDGSGLGFGIVGG-----KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
G + EVEL + + LG + GG + G+ V+ ++P G A+ DGR+ GD +L + G
Sbjct: 1345 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1404
Query: 299 TNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDS 358
+++G T +Q + LRN G V +L+ + + P ++ +GP
Sbjct: 1405 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1464
Query: 359 SLFETYNVELVRKDGQSLGIRIV---GYVGTSHTGE---------ASGIYVKSIIPGSAA 406
+ + V ++ + +++ +G S + E AS + VK + PG A
Sbjct: 1465 KTTQVKDYSFVTEE-NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1523
Query: 407 YHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSD 466
+G I V D I+ V+G +++G + +V+ LR V L L R P P
Sbjct: 1524 AESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR------PPPGVLPEI 1577
Query: 467 RGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENE 526
++ PL+ PA L + + + ++ + +D + +K +K SP
Sbjct: 1578 DTALLTPLQSPAQVLPNSSKDSSQPSCVEQ-------STSSDENEMSDKSKKQCKSPSR- 1629
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
+ + + G + +V T I++ +S L H +S++
Sbjct: 1630 -RDSYSDSSGSGEDDLV-TAPANISNST----WSSAL----------------HQTLSNM 1667
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
VS ED + M Y + F P P L D A
Sbjct: 1668 VSQAQSHHEAPKSQEDTICT---MFYYPQKIPNKPEFEDSNPSP--------LPPDMAPG 1716
Query: 647 DEPRRTETSLPETEVD----HNMDVNTEEDD--------DGELALWSPEVKI-VELVKDC 693
+ S + +D H++ T +++ + L + EV++ + L+K
Sbjct: 1717 QSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSE 1776
Query: 694 KG-LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752
KG LGF++ R + ++ D A+ G L PGDRL+ VN+ + N + +
Sbjct: 1777 KGSLGFTVTKGNQ-----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1830
Query: 753 AVEILKA 759
AV +L+A
Sbjct: 1831 AVNLLRA 1837
Score = 87.0 bits (214), Expect = 1e-16
Identities = 81/291 (27%), Positives = 123/291 (42%), Gaps = 64/291 (21%)
Query: 351 SKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNG 410
S P +FE VEL + D SLGI + G V TS GIYVK++IP AA +G
Sbjct: 1338 SSSPPKPGDIFE---VELAKNDN-SLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDG 1391
Query: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470
I D+++AV+GV+++G + VE LRN GQVVHL L + ++ +S +
Sbjct: 1392 RIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV--------- 1442
Query: 471 VEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVP----DSPENE 526
P+ P ++ N G+ E ++ +K+ + E +V S
Sbjct: 1443 --PVTPQCTL------SDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF 1494
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
SR +NL+ +A + + KL P
Sbjct: 1495 SFSREDNLIPEQI-------------NASIVRVKKLFP---------------------- 1519
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
G P G + D +L+VNG L G S++E +S L+ P L+ CR
Sbjct: 1520 --GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Score = 79.3 bits (194), Expect = 3e-14
Identities = 172/781 (22%), Positives = 289/781 (37%), Gaps = 134/781 (17%)
Query: 145 LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIA 204
LG SV + ++ I+VK V P A+ D R+ + D++LA+N L + +H+QA+
Sbjct: 1359 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL-EGATHKQAVE 1417
Query: 205 LLQQTTGSLRLIVAR-----EPVHTKSSTSSSLNDTTL----PET------------VCW 243
L+ T + L++ + H + +L+D PE V
Sbjct: 1418 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1477
Query: 244 GHVEEVELINDGSGLGF------GIVGGKTSGVVVRT--IVPGGLADRDGRLQTGDHILK 295
+ EV+L + SGLGF ++ + + +VR + PG A G++ GD ILK
Sbjct: 1478 ENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1537
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG 355
+ G +++G++ ++V LR V +L+ R P G V P AL L + A P
Sbjct: 1538 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG---VLPEIDTALLTPLQSPAQVLPN 1594
Query: 356 SDSSLFETYNVELVRKDGQS-----------LGIRIVGYVGTSHTGEASGIYVKSIIPGS 404
S + VE ++ R Y +S +GE + + I S
Sbjct: 1595 SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS 1654
Query: 405 AAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPP 464
H +++ + + + D + + Q + S+ SPL P
Sbjct: 1655 TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQ--KIPNKPEFEDSNPSPLPPD 1712
Query: 465 SDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPE 524
G +P E+ ++ + I + + +N L +
Sbjct: 1713 MAPGQSYQPQS----------ESASSSSMDKYHIHHISEPTRQENWTPL----------K 1752
Query: 525 NELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYIS 584
N+L++ E D+E+ V L T I +E + R+G Y+
Sbjct: 1753 NDLENHLE-----DFELEVELLITLI--KSEKGSLGFTVTKGNQRIGC---------YVH 1796
Query: 585 SIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEA 644
++ P + G L+P D L++VN + + +AV+ L+ LV R L
Sbjct: 1797 DVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVL----- 1850
Query: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQ 704
+ PR LP D + N EE LGFS+
Sbjct: 1851 --ELPR--IPMLPHLLPDITLTCNKEE------------------------LGFSLCGGH 1882
Query: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGL 764
D L V+ I + VA G L D + VN +L E L P L
Sbjct: 1883 DSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSL 1939
Query: 765 VHLGICKPL-VEDNEEESCYILHSSSNEDKTEFSGTIHD----INSSLILEAPKGFRDEP 819
V L V + + S S+ + + G+ N S A + +
Sbjct: 1940 VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEIS 1999
Query: 820 YFK-----EELVDEPFLDLGKSFHSQQKEI-EQSKEAWEMHEFLTPRLQEMDEEREMLVD 873
Y K ++ P L L K + Q+ +I + S+EA E + L +DEE + L++
Sbjct: 2000 YPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEA----EVIQSLLDVVDEEAQNLLN 2055
Query: 874 E 874
E
Sbjct: 2056 E 2056
Score = 66.2 bits (160), Expect = 3e-10
Identities = 41/137 (29%), Positives = 72/137 (52%), Gaps = 6/137 (4%)
Query: 1202 PPPYKALTDDSDENEEEDAFTDQKIRQRYADLPG---ELHIIELEKD-KNGLGLSLAGNK 1257
P K +D S + A+ + +R++ + E+ ++ L+KD K GLG + G +
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGE 1093
Query: 1258 DRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVK 1315
R+ IF+ + P GPA DG ++ GD L+ +N+ L G SH A I++ AP V
Sbjct: 1094 KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVT 1153
Query: 1316 LVFIRNEDAVNQMAVTP 1332
LV + ++ ++++ TP
Sbjct: 1154 LVISQPKEKISKVPSTP 1170
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 11/220 (5%)
Query: 1435 EMIIEISKGRSG-LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
E++I + K G LG ++ G +H+V ++ A + DGRL GD++++VN D+
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDV 1823
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
N +H +A+ LR + VRLV+ R R + P LG S+ G +
Sbjct: 1824 TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHD 1883
Query: 1554 G--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
V+ISDI A ++G L D I VNG + + E V L + + L+
Sbjct: 1884 SLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKA 1943
Query: 1612 GR----LRAGSWTSARTTSQNSQGSQQSAHSSC-HPSFAP 1646
R + S SA + ++++G+ + SC P+ P
Sbjct: 1944 TRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1983
Score = 61.6 bits (148), Expect = 7e-09
Identities = 85/400 (21%), Positives = 162/400 (40%), Gaps = 66/400 (16%)
Query: 369 VRKDGQ-SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
++KD + LG +I+G G GI++ S+ PG A +G ++ D++++V+ V+++
Sbjct: 1077 LKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVET 487
G ++H +E+L+NA + V L + + K S P P + LT
Sbjct: 1135 GVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP---------------VHLT----- 1174
Query: 488 ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLD 547
E+K + A++ K L+ EN GP + +L
Sbjct: 1175 --------NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLS 1226
Query: 548 TQIA--DDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELL 605
+Q + + A L + S++ LG + H G P ++ E E
Sbjct: 1227 SQDSRTESASLSQ-SQVNGFFASHLGDQTWQESQH--------GSPSPSVISKATEKETF 1277
Query: 606 EVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEV---D 662
+ K+++ +S + + + D D T +S + + +
Sbjct: 1278 TDSNQ---SKTKKPGISDVTD-------------YSDRGDSDMDEATYSSSQDHQTPKQE 1321
Query: 663 HNMDVNTEEDDDGELALWSP----EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRS 718
+ VNT + + SP ++ VEL K+ LG S+ + I +++
Sbjct: 1322 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN-TSVRHGGIYVKA 1380
Query: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
++ G AE G + GDR+++VN L+ + +AVE L+
Sbjct: 1381 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1420
Score = 57.8 bits (138), Expect = 9e-08
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 257 GLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
GLGF I+GG+ G + + ++ PGG AD DG L+ GD ++ + +++G++ +
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 312 VLRNCGNSVRMLVARDPAGDISVTPPAPAAL 342
+L+N V +++++ P IS P P L
Sbjct: 1144 ILQNAPEDVTLVISQ-PKEKISKVPSTPVHL 1173
Score = 57.0 bits (136), Expect = 2e-07
Identities = 41/120 (34%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 1498 HEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK----RN 1553
HE +++ Q L V EI V+L+K A GLG I+G R
Sbjct: 1039 HESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRL 1098
Query: 1554 GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
G+FIS + GG ADLDG L GD+++SVN + S IL+ A V L I +
Sbjct: 1099 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 55.8 bits (133), Expect = 4e-07
Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 5/92 (5%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVD--IFVKDVQPGSVADRDQRLKENDQILA 187
R+I +++++ + GLGF ++ + +G++D IF+ V PG AD D LK D++++
Sbjct: 1070 REITLVNLKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1127
Query: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+N L + +SH AI +LQ + L++++
Sbjct: 1128 VNSVSL-EGVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 55.5 bits (132), Expect = 5e-07
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+V + ++ LG I+GG+ K G GIFI V PA LK GD+++
Sbjct: 1074 LVNLKKDAKYGLGFQIIGGE------KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1127
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
V+ V L+ SH A+E ++NA V ++ +P+
Sbjct: 1128 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPS 1168
Score = 52.0 bits (123), Expect = 5e-06
Identities = 91/434 (20%), Positives = 164/434 (37%), Gaps = 45/434 (10%)
Query: 1364 IKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPL--APASSYHSTDADFTGYGGFQAPL 1421
+ +L S +++ S + TK++ S L +P H +D+ G L
Sbjct: 996 VAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVL 1055
Query: 1422 SVDPATCPIVPGQEMIIEI----SKGRSGLGLSIVGGKDTPLN--AIVIHEVYEEGAAAR 1475
V IV E I + + GLG I+GG+ I I V G A
Sbjct: 1056 DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADL 1115
Query: 1476 DGRLWAGDQILEVNGVDLRNSSH-----------EEAITALRQTPQKVRLVV-------- 1516
DG L GD+++ VN V L SH E+ + Q +K+ V
Sbjct: 1116 DGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTN 1175
Query: 1517 ----YRDEAHYRDEENLEIFPVDLQKKAG--RGLGLSIVGKRNG--SGVFISDIVKGGAA 1568
Y ++ Y + ++ D G R + + G G G S + +A
Sbjct: 1176 EMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESA 1235
Query: 1569 DLDGRLIQGDQILSVNGEDMRNASQE---TVATILKCAQGLVQLEIGRLRAGSWTSARTT 1625
L + G S G+ SQ + + I K + + + + + T
Sbjct: 1236 SLSQSQVNGF-FASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1294
Query: 1626 SQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINR-ELS 1684
+ +G ++ + S T Q + S+ + + P+ +I EL+
Sbjct: 1295 DYSDRGDSDMDEAT-YSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELA 1353
Query: 1685 ---DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHA 1741
++LGIS+ GG + + +++ + G A ++ GDR++++NG L+G +H
Sbjct: 1354 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1413
Query: 1742 DVVNLLKNAYGRII 1755
V L+N G+++
Sbjct: 1414 QAVETLRNT-GQVV 1426
Score = 52.0 bits (123), Expect = 5e-06
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 21/135 (15%)
Query: 527 LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI 586
L RW + P+ E+ + L DA+ +++ G ++ D +ISS+
Sbjct: 1058 LHKRWSIVSSPEREITLVNLKK----DAKYGLGFQIIG------GEKMGRLDLGIFISSV 1107
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
GGP D G L+P D L+ VN + L G S A+ L+ P TLV +
Sbjct: 1108 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV-----------I 1156
Query: 647 DEPRRTETSLPETEV 661
+P+ + +P T V
Sbjct: 1157 SQPKEKISKVPSTPV 1171
Score = 50.4 bits (119), Expect = 2e-05
Identities = 33/80 (41%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 683 EVKIVELVKDCK-GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E+ +V L KD K GLGF I+ + + I I S+ G A+ G L PGDRL+SVN
Sbjct: 1071 EITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1129
Query: 742 EYCLDNTSLAEAVEILKAVP 761
L+ S A+EIL+ P
Sbjct: 1130 SVSLEGVSHHAAIEILQNAP 1149
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 107 bits (267), Expect = 1e-22
Identities = 111/425 (26%), Positives = 179/425 (42%), Gaps = 66/425 (15%)
Query: 1239 IIELEKDKNGLGLSLAGNKDRS--RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
++E+ D LG+ + R + + V + G A + R D ++ IN+ L
Sbjct: 274 LVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLR 333
Query: 1297 GRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEE 1356
R + A + + A + +++ A N+ + S S + S P S
Sbjct: 334 NRRFEQAQHMFRQA-MRTPIIWFHVVPAANK---EQYEQLSQSEKNNYYSSRFSPDSQYI 389
Query: 1357 DGSV--EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGY 1414
D G+ + + Q+ + S + P APAS+ +
Sbjct: 390 DNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNV------- 442
Query: 1415 GGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEG 1471
F +S T I G+ + I++ KG GLG SI +D + I + + G
Sbjct: 443 --FSTTVSSGYNTKKI--GKRLNIQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRG 497
Query: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK--VRLVVYRDE-AHYRDEEN 1528
AA +DGRL AGD+++EVNGVDL S EE ++ LR T + V L+V+R E A + E N
Sbjct: 498 AAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
Query: 1529 LE----------------------------IFPVDLQKKAGRGLGLSIVGKRNGS----- 1555
E F V L GLG+S+ G R+
Sbjct: 558 AEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL 617
Query: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGED-MRNASQETVATILKC------AQGLVQ 1608
G+F+ I+ GGAA DGRL DQ+++VNGE + +Q+ + T+ + +G++Q
Sbjct: 618 GIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQ 677
Query: 1609 LEIGR 1613
L + R
Sbjct: 678 LIVAR 682
Score = 93.2 bits (230), Expect = 2e-18
Identities = 84/298 (28%), Positives = 137/298 (45%), Gaps = 29/298 (9%)
Query: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
+NH P + I + +G A P + S+T SS +T G
Sbjct: 408 LNHPP--EQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-----GKRL 460
Query: 248 EVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
++L GLGF I G ++ + V+ I+P G A +DGRL+ GD ++++ G ++
Sbjct: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 303 GMTSEQVAQVLRNCG--NSVRMLVAR-DPAGDISVTPPAPAALPVALPTVASKGP----G 355
G + E+V +LR+ +V +LV R + A P+ + + T A
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTP 580
Query: 356 SDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
+ F T+ V L LG+ + G + + GI+VKSII G AA +G ++VN
Sbjct: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL-GIFVKSIINGGAASKDGRLRVN 639
Query: 416 DKIVAVDGVNIQGFANHDVVEVLR-------NAGQVVHLTLVRR--KTSSSTSPLEPP 464
D+++AV+G ++ G N D +E LR N ++ L + RR K + SP PP
Sbjct: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPP 697
Score = 77.4 bits (189), Expect = 1e-13
Identities = 90/387 (23%), Positives = 157/387 (40%), Gaps = 72/387 (18%)
Query: 1102 IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSS 1161
I++K +L A + LK GD+++EV+GVDL S E V +++ +
Sbjct: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST---------KMEG 538
Query: 1162 TPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAF 1221
T ++ + +D +E P M++P KA E+ED
Sbjct: 539 TVSLLV-----------FRQEDAFHPRE--LNAEPSQMQIPKETKA--------EDEDIV 577
Query: 1222 TDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR---MSIFVVGINPEGPAAAD 1278
+ + L+ + GLG+S+ GN+ + + IFV I G A+ D
Sbjct: 578 LTPDGTREFLTFEVPLN----DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKD 633
Query: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KVKLVFIRNEDAVNQMAVT 1331
GR+R+ D+L+ +N + L G+++Q+A ++ + S ++L+ R N++
Sbjct: 634 GRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNEL--- 690
Query: 1332 PFPVPSSSPS-SIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM-----KQQKY 1385
P S P + ++ + S+ GI+ L ES S A+S++ K Q
Sbjct: 691 --KSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Query: 1386 PT-------KVSFSSQEIPLAP-------ASSYHSTDADFTGYGGFQAPLSV-DPATCPI 1430
PT V +P+ P +SS H T G A ++ D A C +
Sbjct: 749 PTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSL 808
Query: 1431 VPGQEMIIEISKGRSGLGLSIVGGKDT 1457
P + ++ R G G + K T
Sbjct: 809 SPDVDPVLAFQ--REGFGRQSMSEKRT 833
Score = 76.6 bits (187), Expect = 2e-13
Identities = 60/219 (27%), Positives = 105/219 (47%), Gaps = 32/219 (14%)
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
+ T GLGFS+ + G I+VK++ P A +D RLK D+++ +N L S
Sbjct: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL-VGKS 523
Query: 199 HQQAIALLQQT--TGSLRLIVAR------------EPVHTKSSTSSSLNDTTL---PETV 241
++ ++LL+ T G++ L+V R EP + + D + P+
Sbjct: 524 QEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGT 583
Query: 242 CWGHVEEVELINDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHIL 294
EV L + GS GLG + G ++ G+ V++I+ GG A +DGRL+ D ++
Sbjct: 584 REFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI 643
Query: 295 KIGGTNVQGMTSEQVAQVLR-------NCGNSVRMLVAR 326
+ G ++ G T++ + LR N ++++VAR
Sbjct: 644 AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVAR 682
Score = 72.8 bits (177), Expect = 3e-12
Identities = 62/240 (25%), Positives = 107/240 (44%), Gaps = 31/240 (12%)
Query: 1538 KKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
KK GLG SI + G +++ +I+ GAA DGRL GD+++ VNG D+ SQ
Sbjct: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQ 524
Query: 1594 ETVATILKCA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
E V ++L+ +G V L + R + N++ SQ ++
Sbjct: 525 EEVVSLLRSTKMEGTVSLLVFRQE----DAFHPRELNAEPSQMQIPKETKAEDEDIVL-- 578
Query: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL-GDIPVFIAMIQ 1710
P E V +N S LG+S+ G R D+ +F+ I
Sbjct: 579 ----------TPDGTREFLTFE---VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSII 625
Query: 1711 ASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYG-----RIILQVVADTNIS 1765
G A++ +L+V D+++++NG+ L G ++ D + L+ + R ++Q++ IS
Sbjct: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRIS 685
Score = 65.1 bits (157), Expect = 6e-10
Identities = 96/446 (21%), Positives = 172/446 (38%), Gaps = 43/446 (9%)
Query: 359 SLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKI 418
SL + + V DG LGI +V + ++ G G+ VK + G A H + ND I
Sbjct: 267 SLDDMVKLVEVPNDGGPLGIHVVPF--SARGGRTLGLLVKRLEKGGKAEHENLFRENDCI 324
Query: 419 VAVDGVNIQGFANHDVVEVLRNAGQ--VVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKP 476
V ++ +++ + R A + ++ +V L P
Sbjct: 325 VRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSP 384
Query: 477 PALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLG 536
+ ++ +V+ +R L N + ++ ++P S K
Sbjct: 385 DSQYIDNR-----SVNSAGLHTVQRAPRL-NHPPEQIDSHSRLPHSAHPSGKPPSAPASA 438
Query: 537 PDYEVMVATLDTQIADDAELQKYSKLLPIH----TLRLGVEVDSFD------GHHYISSI 586
P T ++ +K K L I T LG + S D Y+ +I
Sbjct: 439 PQN-----VFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNI 493
Query: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
+ G G L+ D L+EVNG+ L GKS+ E VS L+ T+ L +
Sbjct: 494 LPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV---SLLVFRQEDA 550
Query: 647 DEPRRTETSLPETEVDHNMDVNTEEDD-----DGELALWSPEVKIVELVKDCKGLGFSIL 701
PR E + +++ + E++D DG + EV + + GLG S+
Sbjct: 551 FHPR--ELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND--SGSAGLGVSVK 606
Query: 702 DYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK--- 758
+ + I ++S++ G A + G L D+L++VN L + +A+E L+
Sbjct: 607 GNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSM 666
Query: 759 ---AVPPGLVHLGICKPLVEDNEEES 781
G++ L + + + + NE +S
Sbjct: 667 STEGNKRGMIQLIVARRISKCNELKS 692
Score = 55.5 bits (132), Expect = 5e-07
Identities = 64/257 (24%), Positives = 101/257 (39%), Gaps = 52/257 (20%)
Query: 1541 GRGLGLSIV--GKRNGS--GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
G LG+ +V R G G+ + + KGG A+ + + D I+ +N D+RN E
Sbjct: 281 GGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQA 340
Query: 1597 ATILKCA-------------------QGLVQLEIGRL------------------RAGSW 1619
+ + A + L Q E AG
Sbjct: 341 QHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLH 400
Query: 1620 TSARTTSQNSQGSQQSAHS----SCHPSFAPV---ITGLQNLVGTKRVSDPSQKNSGTDM 1672
T R N Q +HS S HPS P + QN+ T S + K G +
Sbjct: 401 TVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRL 460
Query: 1673 EPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSING 1732
+ ++ ++ LG SI + G P+++ I G A + +LK GDR++ +NG
Sbjct: 461 NIQL----KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNG 516
Query: 1733 QPLDGLSHADVVNLLKN 1749
L G S +VV+LL++
Sbjct: 517 VDLVGKSQEEVVSLLRS 533
Score = 40.8 bits (94), Expect = 0.012
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 246 VEEVELINDGSGLGFGIV-----GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
V+ VE+ NDG LG +V GG+T G++V+ + GG A+ + + D I++I +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 301 VQGMTSEQVAQVLR 314
++ EQ + R
Sbjct: 332 LRNRRFEQAQHMFR 345
Score = 39.7 bits (91), Expect = 0.027
Identities = 25/107 (23%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 1045 ELPEREEGEGEE---TPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG 1101
++P+ + E E+ TP+ + V + + LG+S+ G R K G
Sbjct: 564 QIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGN-----RSKENHADLG 618
Query: 1102 IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA 1148
IF+K ++ A K L+ D+++ V+G L ++ +A+E ++ +
Sbjct: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
>gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens]
Length = 1141
Score = 107 bits (266), Expect = 1e-22
Identities = 160/750 (21%), Positives = 286/750 (38%), Gaps = 121/750 (16%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+VE+ ++ +LG++I GG K+G+ + + A +++ L GD I
Sbjct: 145 VVELIKKEGSTLGLTISGGTD-----KDGKPR----VSNLRPGGLAARSDLLNIGDYIRS 195
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQ------SLSSTPRVIP-----NVHNKANK- 1175
V+G+ L H E + +KN G VV V+ + + PR+I +++ + N
Sbjct: 196 VNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSF 255
Query: 1176 ---ITGNQNQDTQEKKE------KRQGTAPPPMKLPPPYKALTDDS-------------- 1212
+ G ++D + + + G A L + L+ D
Sbjct: 256 GFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALAT 315
Query: 1213 -DENEEEDAFT---DQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVG 1268
+ E F D A+ G L + ++ + LG+SL R++ I +
Sbjct: 316 LRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDR 375
Query: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQM 1328
I P G + GD +L I+ + S A+ ++ + KV+L + + +
Sbjct: 376 IKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPL 435
Query: 1329 AVTPFPVPSSSPSSIEDQSGTEP-ISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT 1387
V + P S G + P + ++S
Sbjct: 436 RPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTL 495
Query: 1388 KVSFSSQEIPLAPASSYHSTDADFTG---YGGFQAPLSVDPATCPIVPGQEMI------- 1437
+FS P S + G + S+ A+ + PG +++
Sbjct: 496 NHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEV 555
Query: 1438 IEISKGRSGLGLSIVGG---KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLR 1494
+ SG GL + GG +T + ++ + + A R G L GD++L +NG+
Sbjct: 556 VLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATE 615
Query: 1495 NSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENL----EIFPVDLQKKAGRGLGLSI-- 1548
+ + EEA LR ++V+ E + E++ F V L KK LG++I
Sbjct: 616 DGTMEEANQLLRDAALAHKVVL---EVEFDVAESVIPSSGTFHVKLPKKRSVELGITISS 672
Query: 1549 VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQ 1608
++ G + ISDI KG A G L GD++L+++ + N E IL+ + LV+
Sbjct: 673 ASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVK 732
Query: 1609 LEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNS 1668
L+I ++ D S +
Sbjct: 733 LKI----------------------------------------------RKDEDNSDELE 746
Query: 1669 GTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIV 1728
T TVE+ R LGI+I+G P P+ I+ + G+A RT + VGDRI+
Sbjct: 747 TTGAVSYTVELKR-YGGPLGITISGTE-EPFD--PIVISGLTKRGLAERTGAIHVGDRIL 802
Query: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
+IN L G ++ ++LL+ A + L++
Sbjct: 803 AINNVSLKGRPLSEAIHLLQVAGETVTLKI 832
Score = 81.3 bits (199), Expect = 8e-15
Identities = 76/306 (24%), Positives = 128/306 (41%), Gaps = 46/306 (15%)
Query: 164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH 223
V +++PG +A R L D I ++N L + + H + I LL+ + L V E
Sbjct: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR-LRHDEIITLLKNVGERVVLEVEYE--- 227
Query: 224 TKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGG------KTSGVVVRTIVP 277
+ N + +TV +V L +G+ GF + GG K+ +V+ + P
Sbjct: 228 -LPPPAPENNPRIISKTV------DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRP 280
Query: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPP 337
GG ADR+G L+ GD +L + G + G + LR C + V D
Sbjct: 281 GGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYD---------- 330
Query: 338 APAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYV 397
VA P + G VE+V+ G +LGI + T+ S I +
Sbjct: 331 ------VATPDTVANASG-------PLMVEIVKTPGSALGISLT----TTSLRNKSVITI 373
Query: 398 KSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
I P S +G + D I+++DG +++ + + ++L + + V L ++ S
Sbjct: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL--PVPQS 431
Query: 458 TSPLEP 463
PL P
Sbjct: 432 QRPLRP 437
Score = 74.7 bits (182), Expect = 8e-13
Identities = 101/426 (23%), Positives = 153/426 (35%), Gaps = 93/426 (21%)
Query: 1425 PATCPIVPGQEMIIEISKGRSGLGLSIVGG------KDTPLNAIVIHEVYEEGAAARDGR 1478
P P + + + + + K + G + GG K PL V+ V G A R+G
Sbjct: 233 PENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPL---VLTYVRPGGPADREGS 289
Query: 1479 LWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLE-IFPVDLQ 1537
L GD++L V+G+ L +SH A+ LRQ + V D A N V++
Sbjct: 290 LKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIV 349
Query: 1538 KKAGRGLGLSI--VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
K G LG+S+ RN S + I I D G L GD ILS++G M + S
Sbjct: 350 KTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLE 409
Query: 1596 VATILKCAQGLVQLEI----------------------------------------GRLR 1615
+L V+LEI G R
Sbjct: 410 ATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCR 469
Query: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675
+W + G QS S P +P + + + SQ S R
Sbjct: 470 MPTWAT-------PAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGR 522
Query: 1676 TVEINRELSDALGISIA----GGR------------GSPLGDI----------------P 1703
+ RE +L ++ + GG+ G PL P
Sbjct: 523 RRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSP 582
Query: 1704 VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA--YGRIILQVVAD 1761
+ I+ A R L+VGDR++SING + + + LL++A +++L+V D
Sbjct: 583 PLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFD 642
Query: 1762 TNISAI 1767
S I
Sbjct: 643 VAESVI 648
Score = 68.2 bits (165), Expect = 7e-11
Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 38/227 (16%)
Query: 245 HVEEVELINDG---SGLGFGIVGG------KTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
H E E++ G SG G + GG +S +V I P A+R G LQ GD +L
Sbjct: 549 HTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLS 608
Query: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG 355
I G + T E+ Q+LR+ + ++++ VA + S G
Sbjct: 609 INGIATEDGTMEEANQLLRDAALAHKVVL--------------EVEFDVAESVIPSSG-- 652
Query: 356 SDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
T++V+L +K LGI I ++ + + I GS A+ G ++
Sbjct: 653 -------TFHVKLPKKRSVELGITI----SSASRKRGEPLIISDIKKGSVAHRTGTLEPG 701
Query: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLE 462
DK++A+D + + D V++LR +V L + RK ++ LE
Sbjct: 702 DKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKI--RKDEDNSDELE 746
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/345 (22%), Positives = 139/345 (40%), Gaps = 52/345 (15%)
Query: 167 VQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVARE-PVHTK 225
++P S A+R L+ D++L+IN + + ++A LL+ + ++++ E V
Sbjct: 588 IEPDSPAERCGLLQVGDRVLSINGIATEDG-TMEEANQLLRDAALAHKVVLEVEFDVAES 646
Query: 226 SSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG-VVVRTIVPGGLADRD 284
SS LP+ VEL G+ K +++ I G +A R
Sbjct: 647 VIPSSGTFHVKLPKK------RSVEL-----GITISSASRKRGEPLIISDIKKGSVAHRT 695
Query: 285 GRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPV 344
G L+ GD +L I + E Q+LR C + V++ + +D +
Sbjct: 696 GTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDEL---------- 745
Query: 345 ALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA-SGIYVKSIIPG 403
+++ +Y VEL R G LGI I G T E I + +
Sbjct: 746 ------------ETTGAVSYTVELKRYGG-PLGITISG------TEEPFDPIVISGLTKR 786
Query: 404 SAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL--------TLVRRKTS 455
A G I V D+I+A++ V+++G + + +L+ AG+ V L L+ RK+
Sbjct: 787 GLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSG 846
Query: 456 SSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKE 500
S + + D ++ P A F ++ V+ D E
Sbjct: 847 SLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATE 891
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/257 (26%), Positives = 108/257 (42%), Gaps = 48/257 (18%)
Query: 140 PSTGGLGFSVVALRSQNLGKV----------DIFVKDVQPGSVADRDQRLKENDQILAIN 189
PS+G + RS LG + + D++ GSVA R L+ D++LAI+
Sbjct: 649 PSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAID 708
Query: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVE-E 248
+ LD N + A+ +L+Q ++L + ++ S L T G V
Sbjct: 709 NIRLD-NCPMEDAVQILRQCEDLVKLKIRKD-----EDNSDELETT--------GAVSYT 754
Query: 249 VELINDGSGLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTS 306
VEL G LG I G + +V+ + GLA+R G + GD IL I +++G
Sbjct: 755 VELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPL 814
Query: 307 EQVAQVLRNCGNSVRMLVARD--------PAGDISVTPPA------------PAA-LPVA 345
+ +L+ G +V + + + +G +S T A PAA A
Sbjct: 815 SEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPA 874
Query: 346 LPTVASKGPGSDSSLFE 362
+P+V S DSS E
Sbjct: 875 VPSVDSAVESWDSSATE 891
Score = 60.1 bits (144), Expect = 2e-08
Identities = 52/202 (25%), Positives = 84/202 (41%), Gaps = 40/202 (19%)
Query: 561 KLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKS 616
KL ++ LG+ + S IS I G G L+P D+LL ++ ++L
Sbjct: 657 KLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCP 716
Query: 617 RREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGE 676
+AV L++ C L + + +ED+ E
Sbjct: 717 MEDAVQILRQ---------CEDLV-----------------------KLKIRKDEDNSDE 744
Query: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
L VEL + LG +I ++P DP IVI L G+AER+G + GDR
Sbjct: 745 LETTGAVSYTVELKRYGGPLGITISGTEEPFDP----IVISGLTKRGLAERTGAIHVGDR 800
Query: 737 LVSVNEYCLDNTSLAEAVEILK 758
++++N L L+EA+ +L+
Sbjct: 801 ILAINNVSLKGRPLSEAIHLLQ 822
Score = 53.9 bits (128), Expect = 1e-06
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 13/147 (8%)
Query: 1617 GSWTSARTTSQN-----SQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTD 1671
GSW +A T N S+ + A + G + +R S P + T
Sbjct: 86 GSWWAAGETIANMLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGIT- 144
Query: 1672 MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSIN 1731
VE+ ++ LG++I+GG D ++ ++ G+AAR+ L +GD I S+N
Sbjct: 145 ----VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVN 197
Query: 1732 GQPLDGLSHADVVNLLKNAYGRIILQV 1758
G L L H +++ LLKN R++L+V
Sbjct: 198 GIHLTRLRHDEIITLLKNVGERVVLEV 224
Score = 53.9 bits (128), Expect = 1e-06
Identities = 62/244 (25%), Positives = 97/244 (39%), Gaps = 59/244 (24%)
Query: 1526 EENLEIFPVDLQKKAGRGLGLSIVGKRNGSGV-FISDIVKGGAADLDGRLIQGDQILSVN 1584
EE I V+L KK G LGL+I G + G +S++ GG A L GD I SVN
Sbjct: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVN 197
Query: 1585 GEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSF 1644
G + + + T+LK V LE+
Sbjct: 198 GIHLTRLRHDEIITLLKNVGERVVLEV--------------------------------- 224
Query: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN-RELSDALGISIAGG------RGS 1697
+ P+ +N+ + +TV+++ + ++ G + GG +
Sbjct: 225 ------------EYELPPPAPENNPRIIS-KTVDVSLYKEGNSFGFVLRGGAHEDGHKSR 271
Query: 1698 PLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQ 1757
PL + ++ G A R LKVGDR++S++G PL G SHA + L+ + Q
Sbjct: 272 PL-----VLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQ 326
Query: 1758 VVAD 1761
V D
Sbjct: 327 VEYD 330
Score = 53.5 bits (127), Expect = 2e-06
Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 39/187 (20%)
Query: 578 DGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTL 633
DGH ++ + GGP D G L+ D LL V+G+ L+G S A++ L++
Sbjct: 266 DGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSH---- 321
Query: 634 VCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDC 693
LF E V P +T + G L V+IV+
Sbjct: 322 ---EALFQVEYDVATP------------------DTVANASGPLM-----VEIVKTPGSA 355
Query: 694 KGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEA 753
G+ + ++ +SVI I + V +RSG L PGD ++S++ +++ SL EA
Sbjct: 356 LGISLTTTSLRN-----KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
Query: 754 VEILKAV 760
++L ++
Sbjct: 411 TKLLASI 417
Score = 52.8 bits (125), Expect = 3e-06
Identities = 78/315 (24%), Positives = 125/315 (39%), Gaps = 36/315 (11%)
Query: 1223 DQKIRQRYADLPGELH---IIEL-EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1278
D + R +P E ++EL +K+ + LGL+++G D+ V + P G AA
Sbjct: 126 DVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR-VSNLRPGGLAARS 184
Query: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSS 1338
+ IGD + +N L H ++K +V L + E P P P +
Sbjct: 185 DLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLE-VEYE--------LPPPAPEN 235
Query: 1339 SPSSIEDQSGTEPISSEEDGS----VEVGIKQLPESESFKLAVSQMK-----QQKYPTKV 1389
+P I S T +S ++G+ V G +S L ++ ++ ++ KV
Sbjct: 236 NPRII---SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
Query: 1390 S---FSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVD-----PATCPIVPGQEMIIEIS 1441
S IPL AS H+T +A V+ P T G M+ +
Sbjct: 293 GDRLLSVDGIPLHGAS--HATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVK 350
Query: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501
S LG+S+ + I I + R G L GD IL ++G + + S EA
Sbjct: 351 TPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
Query: 1502 ITALRQTPQKVRLVV 1516
L +KVRL +
Sbjct: 411 TKLLASISEKVRLEI 425
Score = 45.8 bits (107), Expect = 4e-04
Identities = 25/82 (30%), Positives = 48/82 (58%), Gaps = 5/82 (6%)
Query: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
VEL++K+G +LG+ I G GT G+ V ++ PG A + + + D I +V+G++
Sbjct: 146 VELIKKEGSTLGLTISG--GTDKDGKPR---VSNLRPGGLAARSDLLNIGDYIRSVNGIH 200
Query: 426 IQGFANHDVVEVLRNAGQVVHL 447
+ + +++ +L+N G+ V L
Sbjct: 201 LTRLRHDEIITLLKNVGERVVL 222
Score = 44.3 bits (103), Expect = 0.001
Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 42/192 (21%)
Query: 591 PVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPR 650
P + GLLQ D +L +NG+ + EA L++ +V E D
Sbjct: 593 PAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVL-------EVEFDV-- 643
Query: 651 RTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQ--DPLD 708
E+ +P + H + P+ + VEL G+ S + +PL
Sbjct: 644 -AESVIPSSGTFH---------------VKLPKKRSVEL-----GITISSASRKRGEPL- 681
Query: 709 PTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLG 768
+I + VA R+G L PGD+L++++ LDN + +AV+IL+ LV L
Sbjct: 682 ------IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQC-EDLVKLK 734
Query: 769 ICKPLVEDNEEE 780
I K EDN +E
Sbjct: 735 IRKD--EDNSDE 744
Score = 37.4 bits (85), Expect = 0.13
Identities = 44/181 (24%), Positives = 66/181 (36%), Gaps = 30/181 (16%)
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
DG +S++ GG LL D + VNG+ L E ++ LK V L
Sbjct: 167 DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVL---- 222
Query: 638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLG 697
E LP ++N + ++ D V L K+ G
Sbjct: 223 -------------EVEYELPPPAPENNPRIISKTVD-------------VSLYKEGNSFG 256
Query: 698 FSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL 757
F + +V+ + G A+R G L GDRL+SV+ L S A A+ L
Sbjct: 257 FVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATL 316
Query: 758 K 758
+
Sbjct: 317 R 317
Score = 35.4 bits (80), Expect = 0.50
Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
P +VEI + P +LGIS+ T R K+ I I ++ S ++ AL GD I
Sbjct: 343 PLMVEIVKTPGSALGISLT---TTSLRNKS-----VITIDRIKPASVVDRSGALHPGDHI 394
Query: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
L + G +++ S EA + + + V
Sbjct: 395 LSIDGTSMEHCSLLEATKLLASISEKV 421
Score = 35.4 bits (80), Expect = 0.50
Identities = 34/145 (23%), Positives = 62/145 (42%), Gaps = 16/145 (11%)
Query: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
LGI+I G + E I I + + A +T A+ GD+IL ++ V L+
Sbjct: 764 LGITISGTE---------EPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPL 814
Query: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
SEA+ ++ AG V ++ P ++P K+ ++ + D ++ + +G P
Sbjct: 815 SEAIHLLQVAGETVTLKIKKQLDRP-LLP---RKSGSLSETSDAD-EDPADALKGGLPAA 869
Query: 1199 MKLP--PPYKALTDDSDENEEEDAF 1221
P P + + D + E F
Sbjct: 870 RFSPAVPSVDSAVESWDSSATEGGF 894
Score = 35.0 bits (79), Expect = 0.66
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Query: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR- 452
G+YV ++ P A H G +Q D+++ V+ V + F V +L AG V+ L + R+
Sbjct: 1063 GVYVHTVRPDGPA-HRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
Query: 453 -KTSSSTSPLEP 463
SS +P P
Sbjct: 1122 HTAHSSRAPRSP 1133
Score = 33.5 bits (75), Expect = 1.9
Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 3/87 (3%)
Query: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
++I + LG S+ +N K I + ++P SV DR L D IL+I+ T +
Sbjct: 346 VEIVKTPGSALGISLTTTSLRN--KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSM- 402
Query: 195 QNISHQQAIALLQQTTGSLRLIVAREP 221
++ S +A LL + +RL + P
Sbjct: 403 EHCSLLEATKLLASISEKVRLEILPVP 429
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 106 bits (265), Expect = 2e-22
Identities = 106/412 (25%), Positives = 180/412 (43%), Gaps = 95/412 (23%)
Query: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200
G LG VV S G++ +F++ ++ S + R+ EN+ I+ IN+ L D+ +
Sbjct: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
Query: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229
Q + LL + GSL + + PVH KS +
Sbjct: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
Query: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255
++L T PET +++ ++L
Sbjct: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
Query: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
GLGF +V +S + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
Query: 311 QVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVEL 368
+LR+ G + +++AR + P L A S+ FE + L
Sbjct: 451 AMLRSTKQGETASLVIARQEGHFL------PRELKGEPDCCALSLETSEQLTFE---IPL 501
Query: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428
LG+ + G + TG GI++KSII G AA+ +G +++ND+++AV+G ++ G
Sbjct: 502 NDSGSAGLGVSLKGNK-SRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 429 FANHDVVEVLR-------NAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473
+NH+ +E LR N ++ L ++RR P+E P++ G +P
Sbjct: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRR----PERPMEDPAECGAFSKP 608
Score = 103 bits (256), Expect = 2e-21
Identities = 107/454 (23%), Positives = 189/454 (41%), Gaps = 73/454 (16%)
Query: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254
K + DS +N E+ + T + + +D+ +E+ + LG+ +
Sbjct: 164 KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220
Query: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
+ + +F+ GI + +G + +++INN L ++ A + + A
Sbjct: 221 FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280
Query: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
++ + V P P + + G+ I DG ++ + +S
Sbjct: 281 PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327
Query: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431
+ T S S Q+ P P + + GF + +
Sbjct: 328 LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379
Query: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488
+++ I++ KG GLG ++V +D+ ++ I + + +GAA +DGRL +GD+ILEV
Sbjct: 380 --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
Query: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEE----------NLE-----I 1531
NG D+ + EE + LR T Q LV+ R E H+ E +LE
Sbjct: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLT 496
Query: 1532 FPVDLQKKAGRGLGLSIVGKRNGS-----GVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
F + L GLG+S+ G ++ G+FI I+ GGAA DGRL DQ+++VNGE
Sbjct: 497 FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 1587 DMRNASQETVATILKCA-------QGLVQLEIGR 1613
+ S L+ + +G++QL I R
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILR 590
Score = 77.8 bits (190), Expect = 9e-14
Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 36/271 (13%)
Query: 83 LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138
L TD T+ + N S P P+LG + + S + + + I I+
Sbjct: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
+ GLGF+VV S G IFVK++ P A +D RL+ D+IL +N + +
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445
Query: 199 HQQAIALLQQTT--GSLRLIVARE-----PVHTKSSTSSSLNDTTLPETVCWGHVEEVEL 251
++ +A+L+ T + L++AR+ P K E + + E+ L
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF----EIPL 501
Query: 252 INDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
+ GS GLG + G K+ G+ +++I+ GG A +DGRL+ D ++ + G ++ G
Sbjct: 502 NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
Query: 305 TSEQVAQVLR-------NCGNSVRMLVARDP 328
++ + + LR N +++++ R P
Sbjct: 562 SNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 74.3 bits (181), Expect = 1e-12
Identities = 68/235 (28%), Positives = 108/235 (45%), Gaps = 41/235 (17%)
Query: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGD 1578
+ +N + +DL KK GLG ++V + + G G +F+ +I+ GAA DGRL GD
Sbjct: 373 FGSNKNAKKIKIDL-KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431
Query: 1579 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
+IL VNG D+ +QE + +L R+T Q S A
Sbjct: 432 RILEVNGRDVTGRTQEELVAML----------------------RSTKQGETASLVIARQ 469
Query: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEI--NRELSDALGISIAGGRG 1696
H F P + L G S + S E T EI N S LG+S+ G +
Sbjct: 470 EGH--FLP-----RELKGEPDCCALSLETS----EQLTFEIPLNDSGSAGLGVSLKGNKS 518
Query: 1697 SPLG-DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
G D+ +FI I G A + +L++ D+++++NG+ L G S+ + + L+ +
Sbjct: 519 RETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
Score = 58.5 bits (140), Expect = 6e-08
Identities = 60/249 (24%), Positives = 102/249 (40%), Gaps = 60/249 (24%)
Query: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
G TV+ R + IF+K +L A K L++GD+ILEV+G D+ + E V +
Sbjct: 394 GFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAML 453
Query: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGT-APPPMKLPPP 1204
++ Q + +++G P +K P
Sbjct: 454 RST------------------------------KQGETASLVIARQEGHFLPRELKGEPD 483
Query: 1205 YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR--- 1261
AL+ ++ E Q ++P + GLG+SL GNK R
Sbjct: 484 CCALSLETSE-------------QLTFEIPLN------DSGSAGLGVSLKGNKSRETGTD 524
Query: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KV 1314
+ IF+ I G A DGR+R+ D+L+ +N + L G+S+ A ++ + S +
Sbjct: 525 LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMI 584
Query: 1315 KLVFIRNED 1323
+LV +R +
Sbjct: 585 QLVILRRPE 593
Score = 55.8 bits (133), Expect = 4e-07
Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%)
Query: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101
T L +RE G +T + PR + + ++ IS GG I + L G
Sbjct: 171 TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227
Query: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154
+FI+ + ++S + + + I++++ VDL + + ++A + + A +P V
Sbjct: 228 ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287
Query: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190
++ SL+ +V P VH K+ +TG + +T
Sbjct: 288 LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347
Query: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248
+Q +P P + P +L+ ++A +KI+ I+L+K G
Sbjct: 348 QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392
Query: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
LG ++ +D S IFV I P+G A DGR++ GD +LE+N + + GR+ + A
Sbjct: 393 LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
Query: 1306 IIKTAP--SKVKLVFIRNE 1322
++++ LV R E
Sbjct: 452 MLRSTKQGETASLVIARQE 470
Score = 55.8 bits (133), Expect = 4e-07
Identities = 92/428 (21%), Positives = 166/428 (38%), Gaps = 70/428 (16%)
Query: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
P + +L + + +G LGI +V + +S +G G++++ I S + G
Sbjct: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249
Query: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
N+ IV ++ V++ + FA V + +++ ++H+ + + S + + G
Sbjct: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309
Query: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523
V++ PP + ++T N+ G D + +L+ + + +L P SP
Sbjct: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368
Query: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574
+N K + + GP+ V T D+ I +
Sbjct: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-- 632
++ +I+ G G LQ D +LEVNG + G+++ E V+ L+ T
Sbjct: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463
Query: 633 LVCCRR--LFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELV 690
LV R+ F EP SL E + +D G
Sbjct: 464 LVIARQEGHFLPRELKGEPDCCALSL---ETSEQLTFEIPLNDSGS-------------- 506
Query: 691 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
GLG S+ + T I I+S++ G A + G L D+L++VN L S
Sbjct: 507 ---AGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
Query: 751 AEAVEILK 758
EA+E L+
Sbjct: 564 HEAMETLR 571
Score = 40.0 bits (92), Expect = 0.020
Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
+ LG+S+ G K + G +L GIFIK ++ A K L+ D+++ V+G L
Sbjct: 506 SAGLGVSLKGN----KSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 1136 ASHSEAVEAIKNA 1148
S+ EA+E ++ +
Sbjct: 561 KSNHEAMETLRRS 573
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 106 bits (265), Expect = 2e-22
Identities = 106/412 (25%), Positives = 180/412 (43%), Gaps = 95/412 (23%)
Query: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200
G LG VV S G++ +F++ ++ S + R+ EN+ I+ IN+ L D+ +
Sbjct: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
Query: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229
Q + LL + GSL + + PVH KS +
Sbjct: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
Query: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255
++L T PET +++ ++L
Sbjct: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
Query: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
GLGF +V +S + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
Query: 311 QVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVEL 368
+LR+ G + +++AR + P L A S+ FE + L
Sbjct: 451 AMLRSTKQGETASLVIARQEGHFL------PRELKGEPDCCALSLETSEQLTFE---IPL 501
Query: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428
LG+ + G + TG GI++KSII G AA+ +G +++ND+++AV+G ++ G
Sbjct: 502 NDSGSAGLGVSLKGNK-SRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 429 FANHDVVEVLR-------NAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473
+NH+ +E LR N ++ L ++RR P+E P++ G +P
Sbjct: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRR----PERPMEDPAECGAFSKP 608
Score = 103 bits (256), Expect = 2e-21
Identities = 107/454 (23%), Positives = 189/454 (41%), Gaps = 73/454 (16%)
Query: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254
K + DS +N E+ + T + + +D+ +E+ + LG+ +
Sbjct: 164 KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220
Query: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
+ + +F+ GI + +G + +++INN L ++ A + + A
Sbjct: 221 FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280
Query: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
++ + V P P + + G+ I DG ++ + +S
Sbjct: 281 PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327
Query: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431
+ T S S Q+ P P + + GF + +
Sbjct: 328 LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379
Query: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488
+++ I++ KG GLG ++V +D+ ++ I + + +GAA +DGRL +GD+ILEV
Sbjct: 380 --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
Query: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEE----------NLE-----I 1531
NG D+ + EE + LR T Q LV+ R E H+ E +LE
Sbjct: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLT 496
Query: 1532 FPVDLQKKAGRGLGLSIVGKRNGS-----GVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
F + L GLG+S+ G ++ G+FI I+ GGAA DGRL DQ+++VNGE
Sbjct: 497 FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 1587 DMRNASQETVATILKCA-------QGLVQLEIGR 1613
+ S L+ + +G++QL I R
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILR 590
Score = 77.8 bits (190), Expect = 9e-14
Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 36/271 (13%)
Query: 83 LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138
L TD T+ + N S P P+LG + + S + + + I I+
Sbjct: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
Query: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
+ GLGF+VV S G IFVK++ P A +D RL+ D+IL +N + +
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445
Query: 199 HQQAIALLQQTT--GSLRLIVARE-----PVHTKSSTSSSLNDTTLPETVCWGHVEEVEL 251
++ +A+L+ T + L++AR+ P K E + + E+ L
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF----EIPL 501
Query: 252 INDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
+ GS GLG + G K+ G+ +++I+ GG A +DGRL+ D ++ + G ++ G
Sbjct: 502 NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
Query: 305 TSEQVAQVLR-------NCGNSVRMLVARDP 328
++ + + LR N +++++ R P
Sbjct: 562 SNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 74.3 bits (181), Expect = 1e-12
Identities = 68/235 (28%), Positives = 108/235 (45%), Gaps = 41/235 (17%)
Query: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGD 1578
+ +N + +DL KK GLG ++V + + G G +F+ +I+ GAA DGRL GD
Sbjct: 373 FGSNKNAKKIKIDL-KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431
Query: 1579 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
+IL VNG D+ +QE + +L R+T Q S A
Sbjct: 432 RILEVNGRDVTGRTQEELVAML----------------------RSTKQGETASLVIARQ 469
Query: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEI--NRELSDALGISIAGGRG 1696
H F P + L G S + S E T EI N S LG+S+ G +
Sbjct: 470 EGH--FLP-----RELKGEPDCCALSLETS----EQLTFEIPLNDSGSAGLGVSLKGNKS 518
Query: 1697 SPLG-DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
G D+ +FI I G A + +L++ D+++++NG+ L G S+ + + L+ +
Sbjct: 519 RETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
Score = 58.5 bits (140), Expect = 6e-08
Identities = 60/249 (24%), Positives = 102/249 (40%), Gaps = 60/249 (24%)
Query: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
G TV+ R + IF+K +L A K L++GD+ILEV+G D+ + E V +
Sbjct: 394 GFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAML 453
Query: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGT-APPPMKLPPP 1204
++ Q + +++G P +K P
Sbjct: 454 RST------------------------------KQGETASLVIARQEGHFLPRELKGEPD 483
Query: 1205 YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR--- 1261
AL+ ++ E Q ++P + GLG+SL GNK R
Sbjct: 484 CCALSLETSE-------------QLTFEIPLN------DSGSAGLGVSLKGNKSRETGTD 524
Query: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KV 1314
+ IF+ I G A DGR+R+ D+L+ +N + L G+S+ A ++ + S +
Sbjct: 525 LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMI 584
Query: 1315 KLVFIRNED 1323
+LV +R +
Sbjct: 585 QLVILRRPE 593
Score = 55.8 bits (133), Expect = 4e-07
Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%)
Query: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101
T L +RE G +T + PR + + ++ IS GG I + L G
Sbjct: 171 TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227
Query: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154
+FI+ + ++S + + + I++++ VDL + + ++A + + A +P V
Sbjct: 228 ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287
Query: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190
++ SL+ +V P VH K+ +TG + +T
Sbjct: 288 LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347
Query: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248
+Q +P P + P +L+ ++A +KI+ I+L+K G
Sbjct: 348 QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392
Query: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
LG ++ +D S IFV I P+G A DGR++ GD +LE+N + + GR+ + A
Sbjct: 393 LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
Query: 1306 IIKTAP--SKVKLVFIRNE 1322
++++ LV R E
Sbjct: 452 MLRSTKQGETASLVIARQE 470
Score = 55.8 bits (133), Expect = 4e-07
Identities = 92/428 (21%), Positives = 166/428 (38%), Gaps = 70/428 (16%)
Query: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
P + +L + + +G LGI +V + +S +G G++++ I S + G
Sbjct: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249
Query: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
N+ IV ++ V++ + FA V + +++ ++H+ + + S + + G
Sbjct: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309
Query: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523
V++ PP + ++T N+ G D + +L+ + + +L P SP
Sbjct: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368
Query: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574
+N K + + GP+ V T D+ I +
Sbjct: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410
Query: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-- 632
++ +I+ G G LQ D +LEVNG + G+++ E V+ L+ T
Sbjct: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463
Query: 633 LVCCRR--LFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELV 690
LV R+ F EP SL E + +D G
Sbjct: 464 LVIARQEGHFLPRELKGEPDCCALSL---ETSEQLTFEIPLNDSGS-------------- 506
Query: 691 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
GLG S+ + T I I+S++ G A + G L D+L++VN L S
Sbjct: 507 ---AGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
Query: 751 AEAVEILK 758
EA+E L+
Sbjct: 564 HEAMETLR 571
Score = 40.0 bits (92), Expect = 0.020
Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%)
Query: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
+ LG+S+ G K + G +L GIFIK ++ A K L+ D+++ V+G L
Sbjct: 506 SAGLGVSLKGN----KSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 1136 ASHSEAVEAIKNA 1148
S+ EA+E ++ +
Sbjct: 561 KSNHEAMETLRRS 573
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 104 bits (260), Expect = 7e-22
Identities = 179/789 (22%), Positives = 306/789 (38%), Gaps = 175/789 (22%)
Query: 1045 ELPEREEGEGEETPNFSHW-----GPPRIVEIFR----EPNVSLGISIV-----GGQTVI 1090
+ P++E T N ++ PP+ +IF + + SLGIS+ GG V
Sbjct: 1335 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGG--VN 1392
Query: 1091 KRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGN 1150
+++G GI++K V+ A + GD++L V+GV L+ A+H +AVE ++N G
Sbjct: 1393 TSVRHG----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1448
Query: 1151 PVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTD 1210
VV ++ +P +V +QN QG P +K K +
Sbjct: 1449 -VVHLLLEKGQSPTSKEHVPVTPQCTLSDQN---------AQGQGPEKVKKTTQVKDYSF 1498
Query: 1211 DSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA--GNKDRSRMSIFVVG 1268
++EN E ++L K+ +GLG S + N +++ +V
Sbjct: 1499 VTEENTFE---------------------VKLFKNSSGLGFSFSREDNLIPEQINASIVR 1537
Query: 1269 IN---PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAV 1325
+ P PAA G++ +GD +L++N L G S Q + ++ +V L+ R V
Sbjct: 1538 VKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV 1597
Query: 1326 NQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKY 1385
T P SP+ + +S +D S ++Q S+ +++ KQ K
Sbjct: 1598 LPEIDTALLTPLQSPAQVLP-------NSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKS 1650
Query: 1386 PT-KVSFS------SQEIPLAPA--------SSYHSTDADFT--GYGGFQAPLSVDPATC 1428
P+ + S+S ++ APA S+ H T ++ +AP S + C
Sbjct: 1651 PSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTIC 1710
Query: 1429 PI------VPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAG 1482
+ +P + + S L + G+ ++ E A++
Sbjct: 1711 TMFYYPQKIPNKPEFED--SNPSPLPPDMAPGQS--------YQPQSESASS-------- 1752
Query: 1483 DQILEVNGVDLRNSSH-EEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAG 1541
+ +D + H E TP K L E H D E + L K
Sbjct: 1753 ------SSMDKYHIHHISEPTRQENWTPLKNDL-----ENHLEDFELEVELLITLIKSEK 1801
Query: 1542 RGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
LG ++ G ++ D+++ A DGRL GD+++ VN D+ N + +L+
Sbjct: 1802 GSLGFTVTKGNQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1860
Query: 1602 CAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVS 1661
A V+L IGR+ P I L +L
Sbjct: 1861 AASKTVRLVIGRVLE----------------------------LPRIPMLPHL------- 1885
Query: 1662 DPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKL 1721
+ T+ N+E LG S+ GG S L + V+I+ I VAA L
Sbjct: 1886 ----------LPDITLTCNKE---ELGFSLCGGHDS-LYQV-VYISDINPRSVAAIEGNL 1930
Query: 1722 KVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQ-------VVADTNISAIAAQLENM 1774
++ D I +NG G++ +V L + ++L+ VV + SA++A
Sbjct: 1931 QLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTK 1990
Query: 1775 STG-YHLGS 1782
G Y +GS
Sbjct: 1991 GNGSYSVGS 1999
Score = 94.0 bits (232), Expect = 1e-18
Identities = 123/552 (22%), Positives = 221/552 (40%), Gaps = 90/552 (16%)
Query: 244 GHVEEVELINDGSGLGFGIV------GGKTS----GVVVRTIVPGGLADRDGRLQTGDHI 293
G + EVEL + + LG + G TS G+ V+ ++P G A+ DGR+ GD +
Sbjct: 1364 GDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423
Query: 294 LKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKG 353
L + G +++G T +Q + LRN G V +L+ + + P ++ +G
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQG 1483
Query: 354 PGSDSSLFETYNVELVRKDGQSLGIRIV---GYVGTSHTGE---------ASGIYVKSII 401
P + + V ++ + +++ +G S + E AS + VK +
Sbjct: 1484 PEKVKKTTQVKDYSFVTEE-NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLF 1542
Query: 402 PGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPL 461
PG A +G I V D I+ V+G +++G + +V+ LR V L L R P
Sbjct: 1543 PGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR------PPPG 1596
Query: 462 EPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPD 521
P ++ PL+ PA L + + + ++ + +D + +K +K
Sbjct: 1597 VLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQ-------STSSDENEMSDKSKKQCK 1649
Query: 522 SPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH 581
SP + + + G + +V T I++ +S L H
Sbjct: 1650 SPSR--RDSYSDSSGSGEDDLV-TAPANISNST----WSSAL----------------HQ 1686
Query: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
+S++VS ED + M Y + F P P L
Sbjct: 1687 TLSNMVSQAQSHHEAPKSQEDTICT---MFYYPQKIPNKPEFEDSNPSP--------LPP 1735
Query: 642 DEASVDEPRRTETSLPETEVD----HNMDVNTEEDD--------DGELALWSPEVKI-VE 688
D A + S + +D H++ T +++ + L + EV++ +
Sbjct: 1736 DMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLIT 1795
Query: 689 LVKDCKG-LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
L+K KG LGF++ R + ++ D A+ G L PGDRL+ VN+ + N
Sbjct: 1796 LIKSEKGSLGFTVTKGNQ-----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTN 1849
Query: 748 TSLAEAVEILKA 759
+ +AV +L+A
Sbjct: 1850 MTHTDAVNLLRA 1861
Score = 80.9 bits (198), Expect = 1e-14
Identities = 78/294 (26%), Positives = 122/294 (41%), Gaps = 65/294 (22%)
Query: 351 SKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYV---GTSHTGEASGIYVKSIIPGSAAY 407
S P +FE VEL + D SLGI + G + + GIYVK++IP AA
Sbjct: 1357 SSSPPKPGDIFE---VELAKNDN-SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAE 1412
Query: 408 HNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDR 467
+G I D+++AV+GV+++G + VE LRN GQVVHL L + ++ +S +
Sbjct: 1413 SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV------ 1466
Query: 468 GTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVP----DSP 523
P+ P ++ N G+ E ++ +K+ + E +V S
Sbjct: 1467 -----PVTPQCTL------SDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSG 1515
Query: 524 ENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYI 583
SR +NL+ +A + + KL P
Sbjct: 1516 LGFSFSREDNLIPEQI-------------NASIVRVKKLFP------------------- 1543
Query: 584 SSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
G P G + D +L+VNG L G S++E +S L+ P L+ CR
Sbjct: 1544 -----GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592
Score = 77.0 bits (188), Expect = 2e-13
Identities = 168/764 (21%), Positives = 282/764 (36%), Gaps = 134/764 (17%)
Query: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR-- 219
I+VK V P A+ D R+ + D++LA+N L + +H+QA+ L+ T + L++ +
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL-EGATHKQAVETLRNTGQVVHLLLEKGQ 1458
Query: 220 ---EPVHTKSSTSSSLNDTTL----PET------------VCWGHVEEVELINDGSGLGF 260
H + +L+D PE V + EV+L + SGLGF
Sbjct: 1459 SPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF 1518
Query: 261 ------GIVGGKTSGVVVRT--IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV 312
++ + + +VR + PG A G++ GD ILK+ G +++G++ ++V
Sbjct: 1519 SFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISA 1578
Query: 313 LRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKD 372
LR V +L+ R P G V P AL L + A P S + VE
Sbjct: 1579 LRGTAPEVFLLLCRPPPG---VLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSS 1635
Query: 373 GQS-----------LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAV 421
++ R Y +S +GE + + I S H +++ +
Sbjct: 1636 DENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQA 1695
Query: 422 DGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFL 481
+ + D + + Q + S+ SPL P G +P
Sbjct: 1696 QSHHEAPKSQEDTICTMFYYPQ--KIPNKPEFEDSNPSPLPPDMAPGQSYQPQS------ 1747
Query: 482 TGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEV 541
E+ ++ + I + + +N L +N+L++ E D+E+
Sbjct: 1748 ----ESASSSSMDKYHIHHISEPTRQENWTPL----------KNDLENHLE-----DFEL 1788
Query: 542 MVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPE 601
V L T I +E + R+G Y+ ++ P + G L+P
Sbjct: 1789 EVELLITLI--KSEKGSLGFTVTKGNQRIGC---------YVHDVIQ-DPAKSDGRLKPG 1836
Query: 602 DELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEV 661
D L++VN + + +AV+ L+ LV R L + PR LP
Sbjct: 1837 DRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVL-------ELPR--IPMLPHLLP 1887
Query: 662 DHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVA 721
D + N EE LGFS+ D L V+ I +
Sbjct: 1888 DITLTCNKEE------------------------LGFSLCGGHDSL---YQVVYISDINP 1920
Query: 722 DGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPL-VEDNEEE 780
VA G L D + VN +L E L P LV L V + +
Sbjct: 1921 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1980
Query: 781 SCYILHSSSNEDKTEFSGTIHD----INSSLILEAPKGFRDEPYFK-----EELVDEPFL 831
S S+ + + G+ N S A + + Y K ++ P L
Sbjct: 1981 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNL 2040
Query: 832 DLGKSFHSQQKEI-EQSKEAWEMHEFLTPRLQEMDEEREMLVDE 874
L K + Q+ +I + S+EA E + L +DEE + L++E
Sbjct: 2041 TLPKESYIQEDDIYDDSQEA----EVIQSLLDVVDEEAQNLLNE 2080
Score = 64.7 bits (156), Expect = 8e-10
Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 3/100 (3%)
Query: 1236 ELHIIELEKD-KNGLGLSLAGNKDRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINN 1292
E+ ++ L+KD K GLG + G + R+ IF+ + P GPA DG ++ GD L+ +N+
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 1149
Query: 1293 QILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTP 1332
L G SH A I++ AP V LV + ++ ++++ TP
Sbjct: 1150 VSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP 1189
Score = 64.3 bits (155), Expect = 1e-09
Identities = 88/404 (21%), Positives = 164/404 (40%), Gaps = 69/404 (17%)
Query: 369 VRKDGQ-SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
++KD + LG +I+G G GI++ S+ PG A +G ++ D++++V+ V+++
Sbjct: 1096 LKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVET 487
G ++H +E+L+NA + V L + + K S P P + LT
Sbjct: 1154 GVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP---------------VHLT----- 1193
Query: 488 ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLD 547
E+K + A++ K L+ EN GP + +L
Sbjct: 1194 --------NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLS 1245
Query: 548 TQIA--DDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELL 605
+Q + + A L + S++ LG + H G P ++ E E
Sbjct: 1246 SQDSRTESASLSQ-SQVNGFFASHLGDQTWQESQH--------GSPSPSVISKATEKETF 1296
Query: 606 EVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEV---D 662
+ K+++ +S + + + D D T +S + + +
Sbjct: 1297 TDSNQ---SKTKKPGISDVTD-------------YSDRGDSDMDEATYSSSQDHQTPKQE 1340
Query: 663 HNMDVNTEEDDDGELALWSP----EVKIVELVKDCKGLGFSILDYQDPLDPTRSV----I 714
+ VNT + + SP ++ VEL K+ LG S+ D SV I
Sbjct: 1341 SSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGI 1400
Query: 715 VIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
+++++ G AE G + GDR+++VN L+ + +AVE L+
Sbjct: 1401 YVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1444
Score = 62.4 bits (150), Expect = 4e-09
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 11/220 (5%)
Query: 1435 EMIIEISKGRSG-LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
E++I + K G LG ++ G +H+V ++ A + DGRL GD++++VN D+
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDV 1847
Query: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
N +H +A+ LR + VRLV+ R R + P LG S+ G +
Sbjct: 1848 TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHD 1907
Query: 1554 G--SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
V+ISDI A ++G L D I VNG + + E V L + + L+
Sbjct: 1908 SLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKA 1967
Query: 1612 GR----LRAGSWTSARTTSQNSQGSQQSAHSSC-HPSFAP 1646
R + S SA + ++++G+ + SC P+ P
Sbjct: 1968 TRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2007
Score = 57.8 bits (138), Expect = 9e-08
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 257 GLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
GLGF I+GG+ G + + ++ PGG AD DG L+ GD ++ + +++G++ +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 312 VLRNCGNSVRMLVARDPAGDISVTPPAPAAL 342
+L+N V +++++ P IS P P L
Sbjct: 1163 ILQNAPEDVTLVISQ-PKEKISKVPSTPVHL 1192
Score = 56.6 bits (135), Expect = 2e-07
Identities = 41/111 (36%), Positives = 56/111 (50%), Gaps = 5/111 (4%)
Query: 1507 QTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK----RNGSGVFISDI 1562
Q P K V+++ + E EI V+L+K A GLG I+G R G+FIS +
Sbjct: 1068 QVPLKENDVLHKRWSIVSSPER-EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV 1126
Query: 1563 VKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
GG ADLDG L GD+++SVN + S IL+ A V L I +
Sbjct: 1127 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 55.8 bits (133), Expect = 4e-07
Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 5/92 (5%)
Query: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVD--IFVKDVQPGSVADRDQRLKENDQILA 187
R+I +++++ + GLGF ++ + +G++D IF+ V PG AD D LK D++++
Sbjct: 1089 REITLVNLKKDAKYGLGFQIIG--GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
+N L + +SH AI +LQ + L++++
Sbjct: 1147 VNSVSL-EGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 55.5 bits (132), Expect = 5e-07
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
+V + ++ LG I+GG+ K G GIFI V PA LK GD+++
Sbjct: 1093 LVNLKKDAKYGLGFQIIGGE------KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
V+ V L+ SH A+E ++NA V ++ +P+
Sbjct: 1147 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPS 1187
Score = 54.3 bits (129), Expect = 1e-06
Identities = 39/144 (27%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSF 577
+VP + L RW + P+ E+ + L DA+ +++ G ++
Sbjct: 1068 QVPLKENDVLHKRWSIVSSPEREITLVNLKK----DAKYGLGFQIIG------GEKMGRL 1117
Query: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
D +ISS+ GGP D G L+P D L+ VN + L G S A+ L+ P TLV
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV--- 1174
Query: 638 RLFDDEASVDEPRRTETSLPETEV 661
+ +P+ + +P T V
Sbjct: 1175 --------ISQPKEKISKVPSTPV 1190
Score = 51.6 bits (122), Expect = 7e-06
Identities = 27/83 (32%), Positives = 43/83 (51%)
Query: 1668 SGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRI 1727
S + E V + ++ LG I GG D+ +FI+ + G A LK GDR+
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 1728 VSINGQPLDGLSHADVVNLLKNA 1750
+S+N L+G+SH + +L+NA
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNA 1167
Score = 50.4 bits (119), Expect = 2e-05
Identities = 33/80 (41%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 683 EVKIVELVKDCK-GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
E+ +V L KD K GLGF I+ + + I I S+ G A+ G L PGDRL+SVN
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148
Query: 742 EYCLDNTSLAEAVEILKAVP 761
L+ S A+EIL+ P
Sbjct: 1149 SVSLEGVSHHAAIEILQNAP 1168
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/73 (39%), Positives = 37/73 (50%), Gaps = 2/73 (2%)
Query: 1446 GLGLSIVGGKDTPLN--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAIT 1503
GLG I+GG+ I I V G A DG L GD+++ VN V L SH AI
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 1504 ALRQTPQKVRLVV 1516
L+ P+ V LV+
Sbjct: 1163 ILQNAPEDVTLVI 1175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,610,540
Number of Sequences: 37866
Number of extensions: 3494188
Number of successful extensions: 13524
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 10030
Number of HSP's gapped (non-prelim): 2692
length of query: 1801
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1684
effective length of database: 13,817,196
effective search space: 23268158064
effective search space used: 23268158064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.