Guide to the Human Genome
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Search of human proteins with 112382239

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112382239 desmuslin isoform B [Homo sapiens]
         (1253 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112382239 desmuslin isoform B [Homo sapiens]                      2446   0.0  
gi|112382237 desmuslin isoform A [Homo sapiens]                      2246   0.0  
gi|62414289 vimentin [Homo sapiens]                                   153   1e-36
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap...   142   2e-33
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]   142   2e-33
gi|21264345 peripherin [Homo sapiens]                                 142   2e-33
gi|38176300 nestin [Homo sapiens]                                     135   3e-31
gi|55749932 desmin [Homo sapiens]                                     132   2e-30
gi|14249342 internexin neuronal intermediate filament protein, a...   130   6e-30
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]    130   1e-29
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    127   7e-29
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...   113   1e-24
gi|4557701 keratin 17 [Homo sapiens]                                  102   2e-21
gi|10337581 type I hair keratin 3B [Homo sapiens]                      97   7e-20
gi|14917117 keratin 33A [Homo sapiens]                                 96   3e-19
gi|24430192 keratin 16 [Homo sapiens]                                  95   5e-19
gi|94538345 keratin 35 [Homo sapiens]                                  94   6e-19
gi|27436951 lamin B2 [Homo sapiens]                                    94   8e-19
gi|14917115 keratin 31 [Homo sapiens]                                  94   1e-18
gi|4504927 keratin 36 [Homo sapiens]                                   93   1e-18
gi|4504919 keratin 8 [Homo sapiens]                                    92   3e-18
gi|15431310 keratin 14 [Homo sapiens]                                  92   4e-18
gi|27436948 lamin A/C isoform 3 [Homo sapiens]                         91   9e-18
gi|5031875 lamin A/C isoform 2 [Homo sapiens]                          91   9e-18
gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]               91   9e-18
gi|14917119 keratin 34 [Homo sapiens]                                  89   2e-17
gi|195972866 keratin 10 [Homo sapiens]                                 89   2e-17
gi|24430190 keratin 15 [Homo sapiens]                                  87   8e-17
gi|24234699 keratin 19 [Homo sapiens]                                  87   1e-16
gi|5031877 lamin B1 [Homo sapiens]                                     87   1e-16

>gi|112382239 desmuslin isoform B [Homo sapiens]
          Length = 1253

 Score = 2446 bits (6339), Expect = 0.0
 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)

Query: 1    MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
            MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC
Sbjct: 1    MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60

Query: 61   AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
            AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL
Sbjct: 61   AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120

Query: 121  QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
            QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL
Sbjct: 121  QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180

Query: 181  REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
            REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE
Sbjct: 181  REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240

Query: 241  ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
            ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV
Sbjct: 241  ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300

Query: 301  KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
            KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR
Sbjct: 301  KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360

Query: 361  QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
            QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS
Sbjct: 361  QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420

Query: 421  SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
            SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA
Sbjct: 421  SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480

Query: 481  AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
            AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE
Sbjct: 481  AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540

Query: 541  ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
            ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV
Sbjct: 541  ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600

Query: 601  KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
            KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA
Sbjct: 601  KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660

Query: 661  DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
            DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK
Sbjct: 661  DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720

Query: 721  SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
            SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP
Sbjct: 721  SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780

Query: 781  WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
            WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG
Sbjct: 781  WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840

Query: 841  GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
            GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG
Sbjct: 841  GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900

Query: 901  DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
            DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL
Sbjct: 901  DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960

Query: 961  PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
            PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS
Sbjct: 961  PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020

Query: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
            KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES
Sbjct: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080

Query: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
            EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM
Sbjct: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140

Query: 1141 SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG 1200
            SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG
Sbjct: 1141 SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG 1200

Query: 1201 DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253
            DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF
Sbjct: 1201 DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253


>gi|112382237 desmuslin isoform A [Homo sapiens]
          Length = 1565

 Score = 2246 bits (5819), Expect = 0.0
 Identities = 1151/1152 (99%), Positives = 1152/1152 (100%)

Query: 1    MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
            MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC
Sbjct: 1    MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60

Query: 61   AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
            AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL
Sbjct: 61   AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120

Query: 121  QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
            QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL
Sbjct: 121  QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180

Query: 181  REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
            REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE
Sbjct: 181  REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240

Query: 241  ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
            ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV
Sbjct: 241  ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300

Query: 301  KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
            KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR
Sbjct: 301  KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360

Query: 361  QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
            QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS
Sbjct: 361  QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420

Query: 421  SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
            SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA
Sbjct: 421  SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480

Query: 481  AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
            AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE
Sbjct: 481  AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540

Query: 541  ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
            ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV
Sbjct: 541  ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600

Query: 601  KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
            KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA
Sbjct: 601  KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660

Query: 661  DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
            DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK
Sbjct: 661  DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720

Query: 721  SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
            SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP
Sbjct: 721  SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780

Query: 781  WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
            WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG
Sbjct: 781  WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840

Query: 841  GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
            GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG
Sbjct: 841  GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900

Query: 901  DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
            DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL
Sbjct: 901  DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960

Query: 961  PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
            PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS
Sbjct: 961  PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020

Query: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
            KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES
Sbjct: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080

Query: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
            EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM
Sbjct: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140

Query: 1141 SYEGPTAEVVEM 1152
            SYEGPTAEVVE+
Sbjct: 1141 SYEGPTAEVVEV 1152



 Score =  223 bits (567), Expect = 1e-57
 Identities = 133/222 (59%), Positives = 148/222 (66%), Gaps = 29/222 (13%)

Query: 1032 ESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASHSSG 1091
            +SVV ES      P   S ++  GAE  +   R  R      +I  G +E     + +S 
Sbjct: 1373 QSVVSES------PQEDSAEDTSGAEMTSGVSRSFR------HIRLGPTE-----TETSE 1415

Query: 1092 QRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVE 1151
                +GPVS T  ++      +   L D S+  RHI  GP E            T+   +
Sbjct: 1416 HIAIRGPVSRTFVLAGSADSPELGKLADSSRTLRHIAPGPKE------------TSFTFQ 1463

Query: 1152 MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ 1211
            MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ
Sbjct: 1464 MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ 1523

Query: 1212 AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253
            AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF
Sbjct: 1524 AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1565


>gi|62414289 vimentin [Homo sapiens]
          Length = 466

 Score =  153 bits (386), Expect = 1e-36
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 11/314 (3%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCA----EEARS 66
           EK ELQELN R  +Y+ +VR LE++N +L  EL   +G      +G++R      EE R 
Sbjct: 103 EKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKG------QGKSRLGDLYEEEMRE 156

Query: 67  LRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGA 126
           LR+Q+D+L+   A  E ERD L  ++  L+    EE   R   +  L + ++++  A  A
Sbjct: 157 LRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLA 216

Query: 127 RAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDS 186
           R  LE  +  LQ E   L   HE +++EL+A+     +      + P      LR+V   
Sbjct: 217 RLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAA-LRDVRQQ 275

Query: 187 YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQ 246
           Y  + A++ +E  + Y+ +  +L EA  R  ++  QA++E+    ++ ++L  E   L+ 
Sbjct: 276 YESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKG 335

Query: 247 LRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSL 306
               LE  +  M E + ++A   Q  I  L+DE   +   MA  LR+YQDLL VK  L +
Sbjct: 336 TNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDI 395

Query: 307 EVATYRALLEGESN 320
           E+ATYR LLEGE +
Sbjct: 396 EIATYRKLLEGEES 409


>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
           sapiens]
          Length = 431

 Score =  142 bits (359), Expect = 2e-33
 Identities = 101/310 (32%), Positives = 153/310 (49%), Gaps = 3/310 (0%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           E+AE+ ELN R   Y+ +VR LE++N  L  EL   R +E        +   E R LR +
Sbjct: 69  ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQA--ELRELRLR 126

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           LD+L+  +A  E ERD L ++L  +++   +E   R   +  L A ++E  EA  AR  L
Sbjct: 127 LDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDL 186

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
           E  +  L+ E R L   HE +VREL+ + A   +H       P      L+E+   Y  +
Sbjct: 187 ERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAA-LKEIRTQYEAM 245

Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
            + +  E  + Y  +  +L +A  R  E   QA+ E     ++ ++L  +   L      
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305

Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
           LE  +    E +  +A   Q  +  LE+E  +L   MA  L++YQDLL VK  L +E+AT
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365

Query: 311 YRALLEGESN 320
           YR LLEGE N
Sbjct: 366 YRKLLEGEEN 375


>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
          Length = 432

 Score =  142 bits (359), Expect = 2e-33
 Identities = 101/310 (32%), Positives = 153/310 (49%), Gaps = 3/310 (0%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           E+AE+ ELN R   Y+ +VR LE++N  L  EL   R +E        +   E R LR +
Sbjct: 69  ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQA--ELRELRLR 126

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           LD+L+  +A  E ERD L ++L  +++   +E   R   +  L A ++E  EA  AR  L
Sbjct: 127 LDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDL 186

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
           E  +  L+ E R L   HE +VREL+ + A   +H       P      L+E+   Y  +
Sbjct: 187 ERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAA-LKEIRTQYEAM 245

Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
            + +  E  + Y  +  +L +A  R  E   QA+ E     ++ ++L  +   L      
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305

Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
           LE  +    E +  +A   Q  +  LE+E  +L   MA  L++YQDLL VK  L +E+AT
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365

Query: 311 YRALLEGESN 320
           YR LLEGE N
Sbjct: 366 YRKLLEGEEN 375


>gi|21264345 peripherin [Homo sapiens]
          Length = 470

 Score =  142 bits (358), Expect = 2e-33
 Identities = 99/311 (31%), Positives = 156/311 (50%), Gaps = 3/311 (0%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           EK ELQELN R  +++ +VR LE++N  L  EL   RG+E   A     C +E R LR++
Sbjct: 97  EKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEP--ARADQLCQQELRELRRE 154

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           L+ L       + ERD L  +L  L++   EE   R   +  L   ++++ +A  +R  L
Sbjct: 155 LELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLEL 214

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMH-FRARATGPAAPPPRLREVHDSYAL 189
           E  +  L  E   L   HE ++R+L+    S  +      AT        LR++   Y  
Sbjct: 215 ERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYES 274

Query: 190 LVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRA 249
           + A++ +E  + Y+ +  +L +A  R  E+  QA++E     ++ ++L  E  GL     
Sbjct: 275 IAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNE 334

Query: 250 RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVA 309
            L   L  + E++ ++A   Q     LE+E   L   MA  LR+YQ+LL VK  L +E+A
Sbjct: 335 ALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIA 394

Query: 310 TYRALLEGESN 320
           TYR LLEGE +
Sbjct: 395 TYRKLLEGEES 405


>gi|38176300 nestin [Homo sapiens]
          Length = 1621

 Score =  135 bits (339), Expect = 3e-31
 Identities = 106/312 (33%), Positives = 152/312 (48%), Gaps = 6/312 (1%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLR 68
           G E  ++ ELN RL  Y+ RV+ LE +N LL  EL G R +       +A   +E  +LR
Sbjct: 6   GEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSAD-TSWRAHADDELAALR 64

Query: 69  QQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARA 128
             +D+       AE  RD L  EL  +     + R AR R   E+   +R ++    ARA
Sbjct: 65  ALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARA 124

Query: 129 ALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYA 188
            L + +  L+ E   L  AHE +   L A+AA       A   GP AP P + E+    A
Sbjct: 125 WLSSQVAELERELEALRVAHEEERVGLNAQAACAP-RCPAPPRGPPAPAPEVEEL----A 179

Query: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
             + E+WR  V+ Y++ V  +E +L + +E   +A +  R    E + L+ E  GL + R
Sbjct: 180 RRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERR 239

Query: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
           A LE  L    +E     E+ Q  ++ LE EK  L   +A  L   Q L  +K  LSLEV
Sbjct: 240 AALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEV 299

Query: 309 ATYRALLEGESN 320
           ATYR LLE E++
Sbjct: 300 ATYRTLLEAENS 311


>gi|55749932 desmin [Homo sapiens]
          Length = 470

 Score =  132 bits (332), Expect = 2e-30
 Identities = 97/310 (31%), Positives = 153/310 (49%), Gaps = 3/310 (0%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           EK ELQELN R  +Y+ +VR LE++N  L  E+   +GRE           EE R LR+Q
Sbjct: 108 EKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREP--TRVAELYEEELRELRRQ 165

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           ++ L+   A  + ERD L  +L+ L+    EE   +   +  L A + ++  A  AR  L
Sbjct: 166 VEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDL 225

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
           E  +  L  E   L   HE ++REL+A+     +      + P      LR++   Y  +
Sbjct: 226 ERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAA-LRDIRAQYETI 284

Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
            A++  E  + Y+ +V +L +A  +  ++  QA++E      + ++   E   L+     
Sbjct: 285 AAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDS 344

Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
           L   +  + + +  +A   Q  I  LE+E   L   MA  LR+YQDLL VK  L +E+AT
Sbjct: 345 LMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIAT 404

Query: 311 YRALLEGESN 320
           YR LLEGE +
Sbjct: 405 YRKLLEGEES 414


>gi|14249342 internexin neuronal intermediate filament protein,
           alpha [Homo sapiens]
          Length = 499

 Score =  130 bits (328), Expect = 6e-30
 Identities = 101/310 (32%), Positives = 143/310 (46%), Gaps = 2/310 (0%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           EK +LQ LN R   ++ +V +LE +N  LE EL   R R    +        E R LR Q
Sbjct: 94  EKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQ 153

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           L+E S A + A  ERD L  E++ L+    EE   R   +  L AQQR++  A  AR  L
Sbjct: 154 LEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDL 213

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPP--PRLREVHDSYA 188
           E  +  L  E   +   H+ +V EL A   + +          A P     LRE+   Y 
Sbjct: 214 EKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYE 273

Query: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
            L A++ +   + Y+ +   L E   R  E+   + EE     ++ +A   E  GL    
Sbjct: 274 SLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGAN 333

Query: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
             LE  +L + E +  +    Q  I  LE++       MA  LR+YQDLL VK  L +E+
Sbjct: 334 ESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEI 393

Query: 309 ATYRALLEGE 318
           A YR LLEGE
Sbjct: 394 AAYRKLLEGE 403


>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
          Length = 543

 Score =  130 bits (326), Expect = 1e-29
 Identities = 94/311 (30%), Positives = 150/311 (48%), Gaps = 7/311 (2%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           EKA+LQ+LN R   ++ RV ELE++N +LE EL   R +    +  +A   +E R LR  
Sbjct: 90  EKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLA 149

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
            ++ +      +GER+ L   LR LQ    EE  +R   +  L   ++   EA  ARA L
Sbjct: 150 AEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAEL 209

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
           E  +  L  E   L   HE ++ EL+A+     +      T P      L+++   Y  L
Sbjct: 210 EKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDL-SAALKDIRAQYEKL 268

Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRA- 249
            A++ +   + ++     L E+  +  ++   A++E    ++    L+ + L +E  R  
Sbjct: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEV---SESRRLLKAKTLEIEACRGM 325

Query: 250 --RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLE 307
              LE  L  + ++        Q  I+ LE+E  T    MA +L++YQDLL VK  L +E
Sbjct: 326 NEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIE 385

Query: 308 VATYRALLEGE 318
           +A YR LLEGE
Sbjct: 386 IAAYRKLLEGE 396


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  127 bits (319), Expect = 7e-29
 Identities = 210/894 (23%), Positives = 340/894 (38%), Gaps = 86/894 (9%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGRE-GLWAEGQARCAEEARSLRQ 69
           EK +LQ LN R   Y+ +VR+LE  N  LE E    R ++ G  A G+     E R +R 
Sbjct: 97  EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELY-EREVREMRG 155

Query: 70  QLDELSWATALAEGERDALRRELREL-QRLDAEERAARGRLDAELGAQQRELQEALGARA 128
            +  L  A      E++ L  ++  + QRLD E R  R   +A   A  R  QEA  AR 
Sbjct: 156 AVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQ-REEAEAAARALARFAQEAEAARV 214

Query: 129 ALEALLGRLQAERRGLDAAHERDVRELRAR-----AASLTMHFRARATGPAAPPPRLREV 183
            L+     LQ E   L   H+ +V EL  +     AA   M    R          LRE+
Sbjct: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274

Query: 184 ------HDSYALLVAESW-RETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEA 236
                 H   + L +E W R  +    +  +   +A+R  QE   +   + +    E EA
Sbjct: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334

Query: 237 LRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQD 296
           L+     LE+ R+ LED        +       Q  I  L+ E       MA  LR+YQD
Sbjct: 335 LKSTKDSLERQRSELED-------RHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQD 387

Query: 297 LLQVKTGLSLEVATYRALLEGES-----NPEIVIWAEHVENMPS---EFRNKSYHYTDSL 348
           LL VK  L +E+A YR LLEGE       P      E +  +PS     + KS      +
Sbjct: 388 LLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVV 447

Query: 349 LQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSAT 408
            + E E  +   Q          +         +  +     GG+      G   + S  
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTE--EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP 505

Query: 409 TQQENSYGKAVSSQTNVRTFSPTYGLLRNTE-----AQVKTFPDRPKAGDTREVPVYIGE 463
            ++  S  K   S       SP        E     A+VK+ P++ K+    E       
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPPEA 564

Query: 464 DSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTE--VKATREQERNRPETIRTKPE 521
            S    E+      K    A    +   ++    K  E      +E+ ++  E      E
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624

Query: 522 EKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMK--EKAKEKDSPKEKSVREREVPI 579
           E    ++ K+ E+     +E  K  ++A+  E ++ K  EKAK     + KS  + + P+
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684

Query: 580 SLEVSQDRRAE-------VSPKGLQTPVKD-------AGGGTGREAEARELRFRLGTSDA 625
             E     +A+        SP+  ++PVK+       A      EA+  E + +    + 
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE-KAKSPVKEE 743

Query: 626 TGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKTKTE 685
             S +     E      V S   +     E  + AD FP+   + V ++E+    K K+ 
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV-KEEVKSPEKAKSP 802

Query: 686 IVVESKLTE-DVDVSDEAGLDYLLSKDIKEVGLK--GKSAEQMIGDIINLGLKGREGR-- 740
           +  ++K  E ++   +E        +  +EV +K   K AE+          + ++ +  
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862

Query: 741 ------AKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVED---------VSPGPWGLVK 785
                 A    VE  +EP    + EKP+E  V  K EE ED          +P    + +
Sbjct: 863 EAPKKEAPKPKVEEKKEP----AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918

Query: 786 EEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHP 839
           + +   +++V        + K+P +     E   E  D++ E++     P+E P
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA---KKPEEKP 969



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 34/139 (24%), Positives = 62/139 (44%), Gaps = 4/139 (2%)

Query: 436 RNTEAQVKTFPDRPKAGDTREVPVYIGEDSTI-ARESYRDRRDKVAAGASESTRSNERTV 494
           +  EA  K  P +PK  + +E  V   ++S + A++   + + KV     E+    E   
Sbjct: 860 KKEEAPKKEAP-KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918

Query: 495 ILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEK--ASEERNLRWEELTKLDKEARQR 552
               K + +  +++  +      +KP EK   + EK    EE+  + EE  K + +A++ 
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978

Query: 553 ESQQMKEKAKEKDSPKEKS 571
           +    KE +K K    EKS
Sbjct: 979 DKTLSKEPSKPKAEKAEKS 997



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 112/535 (20%), Positives = 206/535 (38%), Gaps = 66/535 (12%)

Query: 544  KLDKEARQRESQQMKEKAKEKDSPKEKSVR----EREVPISLEVSQDRRAEVSPKG-LQT 598
            +LD EARQRE  +   +A  + + + ++ R    ++   +  E    RR      G L  
Sbjct: 184  RLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLG 243

Query: 599  PVKDAGGGTGR-EAEARELRFRLGTS---DATGSLQGDSMTETV-AENIVTSILKQFTQS 653
             ++ +G    + +AE R+      TS   +    L+G ++  T+ +E      L + +++
Sbjct: 244  QIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEA 303

Query: 654  PETEASADSFPDTKVTYVDRK------ELPGERKTKTEIVVESKLTEDVDVSDEAGLDYL 707
             +    A      ++T   R+      EL   + TK  +  +    ED   +D A     
Sbjct: 304  AKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEA 363

Query: 708  LSK-DIKEVGLKGKSAEQM--IGDIINLGLKGREGRAKVVNVEIVE-----EPVSYVSGE 759
            + + D +    K + A Q+    D++N+ +         +++EI       E      G 
Sbjct: 364  IQQLDAELRNTKWEMAAQLREYQDLLNVKM--------ALDIEIAAYRKLLEGEECRIGF 415

Query: 760  KPEEFSVPFKVEEVEDVSPGPWGLVKEEEGY-----GESDVTFSVNQHRRTKQPQENTTH 814
             P  FS+P  + ++  VS      VK EE        E +      Q   T+  +E T  
Sbjct: 416  GPIPFSLPEGLPKIPSVSTHI--KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTE- 472

Query: 815  VEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTR 874
             EE  EA + EG++       +E  GG +            EE ++     +  + +  +
Sbjct: 473  -EEEKEAKEEEGKEEE-GGEEEEAEGGEEETKSP-----PAEEAASPEKEAKSPVKEEAK 525

Query: 875  RRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFH 934
               +      E+   P +V +P    +   +  KE+A+S      P   ++E K P E  
Sbjct: 526  SPAEAKSPEKEEAKSPAEVKSP----EKAKSPAKEEAKSPPEAKSPE--KEEAKSPAEVK 579

Query: 935  TSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGG 994
            +  K   +K P ++  E     E   PE+ +  +    +E    P      VK  + A  
Sbjct: 580  SPEK---AKSPAKE--EAKSPAEAKSPEKAKSPV----KEEAKSPAEAKSPVK--EEAKS 628

Query: 995  SSVTLVAEVNVSQTVDADRLDLEELS--KDEASEMEKAVESVVRESLSRQRSPAP 1047
             +     E   S T +  +   +  S  K+EA   EKA   V  E+ S +++ +P
Sbjct: 629  PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 41/180 (22%), Positives = 76/180 (42%), Gaps = 25/180 (13%)

Query: 447  DRPKAGDTREVPVYIGEDSTIARESYRDRRD-------KVAAGASESTRSNERTVILGKK 499
            ++P+    +E P    E+   A     +++D       K  A   +     E  V   K+
Sbjct: 828  EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887

Query: 500  TEVKATREQ----------ERNRPETIRTK----PEEKMFDSKEKASEERNLRWEELTKL 545
            ++V+A +E+          E+  P  +  K    P+EK  +  +K  ++   +       
Sbjct: 888  SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT-EVAKKEPDDAKAKEPSKPAE 946

Query: 546  DKEARQRESQQMKEKAKE-KDSPK-EKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDA 603
             KEA   +    +EKAK+ ++ PK E   +E +  +S E S+  +AE + K   T  KD+
Sbjct: 947  KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP-KAEKAEKSSSTDQKDS 1005


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score =  113 bits (282), Expect = 1e-24
 Identities = 87/318 (27%), Positives = 151/318 (47%), Gaps = 6/318 (1%)

Query: 4   WRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEE 63
           ++L    EK +LQ LN R   Y+ +V  LE++N  +E E++  R ++   A+      +E
Sbjct: 94  YKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQE 153

Query: 64  ARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEA 123
            R LR  L+ ++   A  + + D L  ++  L+    EE   R   +A + A +++++EA
Sbjct: 154 IRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEA 213

Query: 124 LGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV 183
              +  L+  +  LQ E   L + HE +V +L A+  +  +    +          L+E+
Sbjct: 214 SLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEI 273

Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
                    ++  +  + ++    +L EA  + +E+   A+EE    A+    L+ +++ 
Sbjct: 274 RSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEE---IAEYRRQLQSKSIE 330

Query: 244 LEQLRA---RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
           LE +R     LE  L  + E +       Q  I  LE+E       MA  LR+YQDLL V
Sbjct: 331 LESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNV 390

Query: 301 KTGLSLEVATYRALLEGE 318
           K  L +E+A YR LLEGE
Sbjct: 391 KMALDIEIAAYRKLLEGE 408



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 153/756 (20%), Positives = 276/756 (36%), Gaps = 83/756 (10%)

Query: 202 YEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMR-- 259
           Y+ E+REL   L      + Q + ++    ++   L+       +LR   E A+  +R  
Sbjct: 150 YDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKD 209

Query: 260 -EEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQ-----------VKTGLSLE 307
            EE  +   E  + +  L+DE A L     + + D    +Q           +KT +S  
Sbjct: 210 IEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTA 269

Query: 308 VATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLAS 367
           +   R+ LE  S+  +    E  +   ++    +    +++   + E   + RQ      
Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQ------ 323

Query: 368 FNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRT 427
               S    ++ G + S        + R     S Y  +    +    G       ++R 
Sbjct: 324 LQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLRE 383

Query: 428 FSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVAAGASEST 487
           +     +    + ++  +    +  +TR    + G   +I    Y  R     +   +  
Sbjct: 384 YQDLLNVKMALDIEIAAYRKLLEGEETR-FSTFAG---SITGPLYTHRPPITISSKIQKP 439

Query: 488 RSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDK 547
                      K E    + Q +   E I    E K+ D K +  E      EEL    K
Sbjct: 440 -----------KVEAPKLKVQHKFVEEIIE---ETKVEDEKSEMEEALTAITEELAVSMK 485

Query: 548 EARQRESQQMKEKAKEKDSPKEKSVREREVPISL---EVSQDRRAEVSPKGLQTPVKDAG 604
           E    E ++  E+ +E+   +E+ V  ++ P+     EV ++   +   +G +   ++  
Sbjct: 486 E----EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541

Query: 605 GGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSI---LKQFTQSPETEASAD 661
           G    +AE      + G+S+     Q +  TE  AE          K   +S E     +
Sbjct: 542 GAKSDQAEEGGSE-KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600

Query: 662 SFPDTKVTYVDR-----KELPGERKTKTEI---VVESKLTEDVDVS--DEAGLDYLLSKD 711
              D KV   ++      + P E K K+ +    VE K    V  S  +E G   +    
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 660

Query: 712 IKEVG----LKGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVP 767
           ++E G     K    E+    +    ++  + +A+V   E  EE    V  E P+E  V 
Sbjct: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK-EAPKEEKVE 719

Query: 768 FKVEEVEDV--SPGPWGLVKEEEGYGESDVTFSVNQH--RRTKQPQENTTHVEEVTEAGD 823
            K E+ +DV         VKEE       +T SV  H  + TK+  +     +E  +AG 
Sbjct: 720 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGG 779

Query: 824 SEGEQSYFVSTPDEHPGGHDRDD----GSVYGQIHIEEESTIRYSWQDE---IVQGTRRR 876
             G +       D+   G  ++D    G V G+  +E+E+  + S ++E   +V      
Sbjct: 780 EGGSEE---EGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDL 836

Query: 877 TQKDGAVG-----EKVVKPLDVPAPSLEGDLGSTHW 907
           +  D   G     EKVV    V   + EG  G+T +
Sbjct: 837 SPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKY 872



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 56/242 (23%), Positives = 97/242 (40%), Gaps = 35/242 (14%)

Query: 62  EEARSLRQQLDELSWATALAEGERDALRRELREL---------------QRLDAEERAAR 106
           EE    R+QL   S       G +++L R+L ++               Q+L+ E R  +
Sbjct: 315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374

Query: 107 GRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMH- 165
                E+    RE Q+ L  + AL+     + A R+ L+    R      +    L  H 
Sbjct: 375 W----EMARHLREYQDLLNVKMALDI---EIAAYRKLLEGEETRFSTFAGSITGPLYTHR 427

Query: 166 ----FRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRR-GQESR 220
                 ++   P    P+L+  H     ++ E+        EDE  E+EEAL    +E  
Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEET------KVEDEKSEMEEALTAITEELA 481

Query: 221 LQAEEETRLCAQE-AEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDE 279
           +  +EE +  A+E  E    E   +   ++ ++     ++EE G + EE  +  +  EDE
Sbjct: 482 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541

Query: 280 KA 281
            A
Sbjct: 542 GA 543


>gi|4557701 keratin 17 [Homo sapiens]
          Length = 432

 Score =  102 bits (254), Expect = 2e-21
 Identities = 89/317 (28%), Positives = 143/317 (45%), Gaps = 8/317 (2%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEA 64
           L  G EKA +Q LN RL  Y+ +VR LE  N  LE ++R    R+   A G AR  ++  
Sbjct: 79  LLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQ---APGPARDYSQYY 135

Query: 65  RSLRQQLDELSWATALAEG---ERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQ 121
           R++ +  +++  AT        + D  R    + +     E+A R  ++A++   +R L 
Sbjct: 136 RTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLD 195

Query: 122 EALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR 181
           E   ARA LE  +  L+ E   L   HE ++  LR +     ++    A         L 
Sbjct: 196 ELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGG-EINVEMDAAPGVDLSRILN 254

Query: 182 EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREA 241
           E+ D Y  +  ++ ++    +  +  EL   +    E     + E     +  +AL  E 
Sbjct: 255 EMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIEL 314

Query: 242 LGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVK 301
                ++A LE  L      Y +Q  + Q +I  +E++ A L   M    ++Y+ LL VK
Sbjct: 315 QSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVK 374

Query: 302 TGLSLEVATYRALLEGE 318
           T L  E+ATYR LLEGE
Sbjct: 375 TRLEQEIATYRRLLEGE 391


>gi|10337581 type I hair keratin 3B [Homo sapiens]
          Length = 404

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 89/323 (27%), Positives = 141/323 (43%), Gaps = 15/323 (4%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
           G EK  +Q LN RL  Y+ +VR+LER+N  LE  +R R + +E L         +    L
Sbjct: 54  GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113

Query: 68  RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
           +Q++       A    + D  +    + +     E++ R  +++++ + +R L E    R
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCR 173

Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV---- 183
           + LEA +  L+ E   L   HE++V  LR +        R      AAP   L +V    
Sbjct: 174 SDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGD-----RLNVEVDAAPAVDLNQVLNET 228

Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
            + Y  LV  + RE  Q +  +  EL + +    E     + E     +   AL  E   
Sbjct: 229 RNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288

Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
              LR  LE+ L      Y  Q  + Q +I  +E + A +   +    ++YQ LL V+  
Sbjct: 289 QHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348

Query: 304 LSLEVATYRALLEGE-----SNP 321
           L  E+ TYR+LLE E     SNP
Sbjct: 349 LECEINTYRSLLESEDCKLPSNP 371


>gi|14917117 keratin 33A [Homo sapiens]
          Length = 404

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 90/323 (27%), Positives = 139/323 (43%), Gaps = 15/323 (4%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
           G EK  +Q LN RL  Y+ +VR+LER+N  LE  +R R + +E L         +    L
Sbjct: 54  GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEEL 113

Query: 68  RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
           +Q++       A    + D  +    + +     E + R  +++++   +R L E    R
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVESDINGLRRILDELTLCR 173

Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV---- 183
           + LEA +  L+ E   L   HE++V  LR +        R      AAP   L +V    
Sbjct: 174 SDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGD-----RLNVEVDAAPTVDLNQVLNET 228

Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
              Y  LV  + RE  Q +  +  EL + +    E     + E     +   AL  E   
Sbjct: 229 RSQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288

Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
              LR  LE+ L      Y  Q  + QR+I  +E + A +   +    ++YQ LL V+  
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348

Query: 304 LSLEVATYRALLEGE-----SNP 321
           L  E+ TYR+LLE E     SNP
Sbjct: 349 LECEINTYRSLLESEDCKLPSNP 371


>gi|24430192 keratin 16 [Homo sapiens]
          Length = 473

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 84/314 (26%), Positives = 137/314 (43%), Gaps = 2/314 (0%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREG-LWAEGQARCAEEA 64
           L  G EK  +Q LN RL  Y+ +VR LE  N  LE ++R    R+     +  +   +  
Sbjct: 112 LLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTI 171

Query: 65  RSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEAL 124
             LR ++   +   A    + D  R    + +     E A R  ++A++   +R L E  
Sbjct: 172 EDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELT 231

Query: 125 GARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVH 184
            AR  LE  +  L+ E   L   HE ++  LR +     ++    A         L E+ 
Sbjct: 232 LARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGG-DVNVEMDAAPGVDLSRILNEMR 290

Query: 185 DSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGL 244
           D Y  +  ++ R+    +  +  EL + +    E    +  E     +  + L  E    
Sbjct: 291 DQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQ 350

Query: 245 EQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGL 304
             ++A LE++L   +  Y +Q  + Q +I  +E++ A L   M    ++YQ LL VKT L
Sbjct: 351 LSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRL 410

Query: 305 SLEVATYRALLEGE 318
             E+ATYR LLEGE
Sbjct: 411 EQEIATYRRLLEGE 424


>gi|94538345 keratin 35 [Homo sapiens]
          Length = 455

 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 88/326 (26%), Positives = 140/326 (42%), Gaps = 26/326 (7%)

Query: 8   TGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEARS 66
           TG EK  +Q LN RL  Y+ +VR+LE+EN  LE  +R        W E Q      + +S
Sbjct: 94  TGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIRE-------WCEQQVPYMCPDYQS 146

Query: 67  LRQQLDELSWATALAEGERDALRRELRELQRLDAE--------ERAARGRLDAELGAQQR 118
             + ++EL   T  ++ E   L  E+ +  +L A+        E + R  +++++   +R
Sbjct: 147 YFRTIEELQKKTLCSKAENARLVVEI-DNAKLAADDFRTKYETEVSLRQLVESDINGLRR 205

Query: 119 ELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPP 178
            L +    ++ LEA +  L+ E   L   HE +V  LR +        R      AAPP 
Sbjct: 206 ILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGD-----RLNVEVDAAPPV 260

Query: 179 RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEA 234
            L  V +     Y  LV  + R+     + +  EL + +    E     + E     +  
Sbjct: 261 DLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTV 320

Query: 235 EALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDY 294
            AL  E      +R  LE  L      Y  Q  + Q +I  +E + A +   +    ++Y
Sbjct: 321 NALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEY 380

Query: 295 QDLLQVKTGLSLEVATYRALLEGESN 320
           Q LL V+  L  E+ TYR LLE E +
Sbjct: 381 QVLLDVRARLECEINTYRGLLESEDS 406


>gi|27436951 lamin B2 [Homo sapiens]
          Length = 600

 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 94/362 (25%), Positives = 143/362 (39%), Gaps = 51/362 (14%)

Query: 5   RLQTGPEKAELQELNARLYDYVCRVRELEREN----------------------LLLEEE 42
           RL    EK EL+ELN RL  Y+ RVR LE EN                       L E E
Sbjct: 20  RLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESE 79

Query: 43  LRGRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLD--- 99
           L   R      A  +AR   E   LR +LDE++ +    EGE    +  +++L+ L    
Sbjct: 80  LADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRS 139

Query: 100 ------------------AEERAARGRLDAELGAQQRELQEALGARAALEALLGRLQAER 141
                             AE RA   + +      +++L++    R  LE     LQ E 
Sbjct: 140 EVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEEL 199

Query: 142 RGLDAAHERDVRELRARAASLTMHFRARATGP-----AAPPPRLREVHDSYALLVAESWR 196
               +  E +VRE R R     +   +          A     LR  HD    L      
Sbjct: 200 DFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259

Query: 197 ETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALL 256
           +T Q   D  +   +   +  ++   A EE +      E+L  +  GL++  +  ED + 
Sbjct: 260 QTYQAKLDSAKLSSD---QNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIR 316

Query: 257 RMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLE 316
            + E    + ++ ++++D  E E   +   M   L +YQ+LL VK  L +E+  YR LLE
Sbjct: 317 ELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376

Query: 317 GE 318
           GE
Sbjct: 377 GE 378


>gi|14917115 keratin 31 [Homo sapiens]
          Length = 416

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 88/323 (27%), Positives = 138/323 (42%), Gaps = 15/323 (4%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
           G EK  +Q LN RL  Y+ +VR+LER+N  LE  +R R + +E L         +    L
Sbjct: 54  GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113

Query: 68  RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
           +Q++       A    + D  +    + +     E + R  +++++   +R L E    +
Sbjct: 114 QQKILCTKSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDINGLRRILDELTLCK 173

Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR----EV 183
           + LEA +  L+ E   L + HE++V  LR +        R      AAP   L     E 
Sbjct: 174 SDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGD-----RLNVEVDAAPTVDLNRVLNET 228

Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
              Y  LV  + RE  Q +  +  EL + +    E     + E     +   AL  E   
Sbjct: 229 RSQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288

Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
              LR  LE+ L      Y  Q  + Q +I  +E + A +   +    ++YQ LL V+  
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348

Query: 304 LSLEVATYRALLEGE-----SNP 321
           L  E+ TYR+LLE E     SNP
Sbjct: 349 LECEINTYRSLLESEDCNLPSNP 371


>gi|4504927 keratin 36 [Homo sapiens]
          Length = 467

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 91/330 (27%), Positives = 145/330 (43%), Gaps = 40/330 (12%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEARSL 67
           G EK  +Q LN RL +Y+ +VR+LEREN  LE  ++        W E Q      + +S 
Sbjct: 91  GSEKETMQFLNDRLANYLEKVRQLERENAELESRIQE-------WYEFQIPYICPDYQSY 143

Query: 68  RQQLDELSWATALAEGERDALRRELRELQRLDAE--------ERAARGRLDAELGAQQRE 119
            + +++      L + E   L  ++ +  +L A+        E + R  ++A++   +R 
Sbjct: 144 FKTIEDFQQKILLTKSENARLVLQI-DNAKLAADDFRTKYETELSLRQLVEADINGLRRI 202

Query: 120 LQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPR 179
           L E    +A LEA +  L+ E   L   HE +V  LR +        R      AAPP  
Sbjct: 203 LDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGD-----RLNVEVDAAPPVD 257

Query: 180 LREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAE 235
           L ++ +     Y  LV  + R+    +  +  EL + +       + + E+ + C  E  
Sbjct: 258 LNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQV-------VSSSEQLQCCQTEII 310

Query: 236 ALRREALGLE-------QLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMA 288
            LRR    LE        +R  LE  L      Y  Q  + Q +I  +E + + +   + 
Sbjct: 311 ELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLE 370

Query: 289 DWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
              ++YQ LL VK  L  E+ATYR LLEGE
Sbjct: 371 RQNQEYQVLLDVKARLEGEIATYRHLLEGE 400


>gi|4504919 keratin 8 [Homo sapiens]
          Length = 483

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 84/379 (22%), Positives = 162/379 (42%), Gaps = 11/379 (2%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
           EK +++ LN +   ++ +VR LE++N +LE +    + ++   +           +LR+Q
Sbjct: 91  EKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQ 150

Query: 71  LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
           L+ L       E E   ++  + + +    +E   R  ++ E    ++++ EA   +  L
Sbjct: 151 LETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVEL 210

Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
           E+ L  L  E   L   +E ++REL+++ +  ++      +        + EV   Y  +
Sbjct: 211 ESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDI 270

Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
              S  E   +Y+ +  EL+    +  +   + + E     +    L+ E  GL+  RA 
Sbjct: 271 ANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRAS 330

Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
           LE A+    +   +  ++    +  LE         MA  LR+YQ+L+ VK  L +E+AT
Sbjct: 331 LEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIAT 390

Query: 311 YRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNH 370
           YR LLEGE +            + S  +N S H   +        + +    +P  S++ 
Sbjct: 391 YRKLLEGEES-----------RLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSL 439

Query: 371 SSALYSNLSGHRGSQTGTS 389
            S+  S       S+T +S
Sbjct: 440 GSSFGSGAGSSSFSRTSSS 458


>gi|15431310 keratin 14 [Homo sapiens]
          Length = 472

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 82/314 (26%), Positives = 137/314 (43%), Gaps = 2/314 (0%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREG-LWAEGQARCAEEA 64
           L  G EK  +Q LN RL  Y+ +VR LE  N  LE ++R    R+     +  +   +  
Sbjct: 110 LLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTI 169

Query: 65  RSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEAL 124
             LR ++   +   A    + D  R    + +     E   R  ++A++   +R L E  
Sbjct: 170 EDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELT 229

Query: 125 GARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVH 184
            ARA LE  +  L+ E   L   HE ++  LR +     ++    A         L E+ 
Sbjct: 230 LARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGG-DVNVEMDAAPGVDLSRILNEMR 288

Query: 185 DSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGL 244
           D Y  +  ++ ++  + +  +  EL   +    E     + E     +  + L  E    
Sbjct: 289 DQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQ 348

Query: 245 EQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGL 304
             ++A LE++L   +  Y +Q  + Q +I  +E++ A L   M    ++Y+ LL VKT L
Sbjct: 349 LSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRL 408

Query: 305 SLEVATYRALLEGE 318
             E+ATYR LLEGE
Sbjct: 409 EQEIATYRRLLEGE 422


>gi|27436948 lamin A/C isoform 3 [Homo sapiens]
          Length = 634

 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
           EK +LQELN RL  Y+ RVR LE EN  L                      E EL   R 
Sbjct: 31  EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90

Query: 49  REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
                A+ +AR   E   +R++  EL       EG+  A +  L++L+ L   + AA   
Sbjct: 91  TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150

Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
             +E    + EL +  G  A LEA LG  +A+++  D    R   E R +     + F+ 
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208

Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
                           RL E+ +     +   +A++ +E    +ED+V + ++ L +   
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268

Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
           ++L      AE  + L     E L++  + ++ L A+L         ++A LR + +   
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328

Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
            + +  +R++   E E A +   M   L +YQ+LL +K  L +E+  YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383


>gi|5031875 lamin A/C isoform 2 [Homo sapiens]
          Length = 572

 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
           EK +LQELN RL  Y+ RVR LE EN  L                      E EL   R 
Sbjct: 31  EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90

Query: 49  REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
                A+ +AR   E   +R++  EL       EG+  A +  L++L+ L   + AA   
Sbjct: 91  TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150

Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
             +E    + EL +  G  A LEA LG  +A+++  D    R   E R +     + F+ 
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208

Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
                           RL E+ +     +   +A++ +E    +ED+V + ++ L +   
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268

Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
           ++L      AE  + L     E L++  + ++ L A+L         ++A LR + +   
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328

Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
            + +  +R++   E E A +   M   L +YQ+LL +K  L +E+  YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383


>gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
          Length = 664

 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)

Query: 11  EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
           EK +LQELN RL  Y+ RVR LE EN  L                      E EL   R 
Sbjct: 31  EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90

Query: 49  REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
                A+ +AR   E   +R++  EL       EG+  A +  L++L+ L   + AA   
Sbjct: 91  TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150

Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
             +E    + EL +  G  A LEA LG  +A+++  D    R   E R +     + F+ 
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208

Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
                           RL E+ +     +   +A++ +E    +ED+V + ++ L +   
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268

Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
           ++L      AE  + L     E L++  + ++ L A+L         ++A LR + +   
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328

Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
            + +  +R++   E E A +   M   L +YQ+LL +K  L +E+  YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383


>gi|14917119 keratin 34 [Homo sapiens]
          Length = 436

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 86/320 (26%), Positives = 140/320 (43%), Gaps = 20/320 (6%)

Query: 9   GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
           G EK  +Q LN RL  Y+ +VR+LER+N  LE+ ++ R + +E L         +    L
Sbjct: 96  GSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEEL 155

Query: 68  RQQLDELSWATALAEGERDALRRELRELQRLDAE-----ERAARGRLDAELGAQQRELQE 122
           +Q++       A AE  R  +  +  +L   D       E++ R  +++++ + +R L E
Sbjct: 156 QQKI-----LCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDE 210

Query: 123 ALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLRE 182
               ++ LE+ +  L+ E   L   HE +V  LR++        R       AP   L +
Sbjct: 211 LTLCKSDLESQVESLREELICLKKNHEEEVNTLRSQLGD-----RLNVEVDTAPTVDLNQ 265

Query: 183 V----HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALR 238
           V       Y  LV  + RE  Q +  +  EL + +    E     + E     +   AL 
Sbjct: 266 VLNETRSQYEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALE 325

Query: 239 REALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLL 298
            E      LR  LE+ L      Y  Q  + Q +I  +E + A +   +    ++YQ LL
Sbjct: 326 IELQAQHNLRDSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLL 385

Query: 299 QVKTGLSLEVATYRALLEGE 318
            V+  L  E+ TYR+LLE E
Sbjct: 386 DVRARLECEINTYRSLLESE 405


>gi|195972866 keratin 10 [Homo sapiens]
          Length = 584

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 79/319 (24%), Positives = 136/319 (42%), Gaps = 5/319 (1%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEE-- 63
           L +G EK  +Q LN RL  Y+ +VR LE  N  LE +++    + G   +G+ R   +  
Sbjct: 141 LLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYY 200

Query: 64  --ARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQ 121
                L+ Q+  L+   A    + D  R    + +     E A R  ++A++   +R L 
Sbjct: 201 KTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLD 260

Query: 122 EALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR 181
           E    +A LE  +  L  E   L   HE ++++LR   ++  ++    A         L 
Sbjct: 261 ELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLR-NVSTGDVNVEMNAAPGVDLTQLLN 319

Query: 182 EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREA 241
            +   Y  L  ++ ++    + ++ +EL   +    E     + E     +  +AL  E 
Sbjct: 320 NMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIEL 379

Query: 242 LGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVK 301
                L+  LE +L      Y +Q  + Q  I  LE++   +         +YQ LL +K
Sbjct: 380 QSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIK 439

Query: 302 TGLSLEVATYRALLEGESN 320
             L  E+ TYR+LLEGE +
Sbjct: 440 IRLENEIQTYRSLLEGEGS 458


>gi|24430190 keratin 15 [Homo sapiens]
          Length = 456

 Score = 87.4 bits (215), Expect = 8e-17
 Identities = 84/326 (25%), Positives = 141/326 (43%), Gaps = 25/326 (7%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEAR 65
           L +G EK  +Q LN RL  Y+ +VR LE  N  LE ++         W + Q   + E  
Sbjct: 100 LLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHD-------WYQKQTPTSPECD 152

Query: 66  SLR-----QQLDELSWATALAEG----ERDALRRELRELQRLDAEERAARGRLDAELGAQ 116
             +     ++L +   AT +       E D  R    + +     E A R  ++A++   
Sbjct: 153 YSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGL 212

Query: 117 QRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAP 176
           +R L E   AR  LE  +  L  E   L   HE +++E  ++ A      +      AAP
Sbjct: 213 RRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAG-----QVNVEMDAAP 267

Query: 177 PPRLR----EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQ 232
              L     E+ + Y  +  ++ R+    +  +  EL + +    E    ++ E     +
Sbjct: 268 GVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRR 327

Query: 233 EAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLR 292
             + L  E      ++A LE++L      Y  Q ++ Q +I  LE + + L   M    +
Sbjct: 328 TMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQ 387

Query: 293 DYQDLLQVKTGLSLEVATYRALLEGE 318
           +Y+ LL +KT L  E+ATYR+LLEG+
Sbjct: 388 EYKMLLDIKTRLEQEIATYRSLLEGQ 413


>gi|24234699 keratin 19 [Homo sapiens]
          Length = 400

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 89/328 (27%), Positives = 141/328 (42%), Gaps = 26/328 (7%)

Query: 6   LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEAR 65
           L  G EK  +Q LN RL  Y+ +VR LE  N  LE ++R    ++G    G +R      
Sbjct: 75  LLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQG---PGPSRDYSHYY 131

Query: 66  SLRQQL-DELSWATALAEGERDALRRELRELQRLDAE-----ERAARGRLDAELGAQQRE 119
           +  Q L D++  AT   E  R  L+ +   L   D       E+A R  ++A++   +R 
Sbjct: 132 TTIQDLRDKILGATI--ENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRV 189

Query: 120 LQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPR 179
           L E   AR  LE  +  L+ E   L   HE ++  LR +           A G       
Sbjct: 190 LDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKI- 248

Query: 180 LREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRR 239
           L ++   Y ++  ++ ++    +     EL   +  G   +LQ      +   E   LRR
Sbjct: 249 LSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVA-GHTEQLQ------MSRSEVTDLRR 301

Query: 240 EALGLE-------QLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLR 292
              GLE        ++A LED L      +G Q    Q +I  +E +   +        +
Sbjct: 302 TLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQ 361

Query: 293 DYQDLLQVKTGLSLEVATYRALLEGESN 320
           +YQ L+ +K+ L  E+ATYR+LLEG+ +
Sbjct: 362 EYQRLMDIKSRLEQEIATYRSLLEGQED 389


>gi|5031877 lamin B1 [Homo sapiens]
          Length = 586

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 102/362 (28%), Positives = 162/362 (44%), Gaps = 51/362 (14%)

Query: 5   RLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR---RGRE--GLWAEGQAR 59
           RL    EK EL+ELN RL  Y+ +VR LE EN  L+ ++  R   RGRE  GL A  +  
Sbjct: 26  RLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETE 85

Query: 60  CAEEARSLRQQLDE---LSWATALAEGERDALRRELRELQRLDAEERAARGRL---DAEL 113
            A+  R+L     E   L       + E D L   L    + +++   A+ +L   +A L
Sbjct: 86  LADARRALDDTARERAKLQIELGKCKAEHDQL---LLNYAKKESDLNGAQIKLREYEAAL 142

Query: 114 GAQQRELQEALGARAALEALLGRLQAERRGLDA---------AHERDVR-ELRARAASLT 163
            ++   L  ALG + +LE  L  L+ +   L+A         A E  ++ +L  R  SLT
Sbjct: 143 NSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLT 202

Query: 164 MHFRARATGPAAPPPRLREVHDS------------YALLVAESWRETVQLYEDEVRELEE 211
                R +         R  H++            Y   +A++  E  + ++ +VR  +E
Sbjct: 203 EDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKE 262

Query: 212 ALRRG-----QESRLQAEEETRLCAQEAEALRREALGLEQLRARLED-------ALLRMR 259
            L +      + +RL +E  T       E L    + +E L ++L +        L R++
Sbjct: 263 ELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQ 322

Query: 260 EEYGIQAEER---QRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLE 316
           E   + A+E+   +R++   E E A +   M   L DY+ LL VK  L +E++ YR LLE
Sbjct: 323 ELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLE 382

Query: 317 GE 318
           GE
Sbjct: 383 GE 384


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.127    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,821,352
Number of Sequences: 37866
Number of extensions: 2336876
Number of successful extensions: 18426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 776
Number of HSP's that attempted gapping in prelim test: 10396
Number of HSP's gapped (non-prelim): 5101
length of query: 1253
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1139
effective length of database: 13,930,794
effective search space: 15867174366
effective search space used: 15867174366
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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