Guide to the Human Genome
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Search of human proteins with 166706868

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
         (977 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]            1982   0.0  
gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]             1460   0.0  
gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                  349   8e-96
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                  341   2e-93
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                  340   3e-93
gi|158303333 synaptopodin isoform B [Homo sapiens]                    154   3e-37
gi|40353727 synaptopodin isoform A [Homo sapiens]                     147   6e-35
gi|163965366 nascent polypeptide-associated complex alpha subuni...   115   3e-25
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   102   2e-21
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   99   2e-20
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   99   2e-20
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   99   2e-20
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    99   2e-20
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    94   5e-19
gi|55750053 atrophin-1 [Homo sapiens]                                  94   5e-19
gi|55750041 atrophin-1 [Homo sapiens]                                  94   5e-19
gi|160707881 formin 2 [Homo sapiens]                                   92   2e-18
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    90   9e-18
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         90   9e-18
gi|47132519 Ras association and pleckstrin homology domains 1 is...    88   3e-17
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  87   6e-17
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    86   2e-16
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     82   3e-15
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              79   2e-14
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    79   2e-14
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    79   2e-14
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    79   2e-14
gi|118402590 myosin XV [Homo sapiens]                                  78   4e-14
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              78   4e-14
gi|116284392 mucin 2 precursor [Homo sapiens]                          77   6e-14

>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score = 1982 bits (5135), Expect = 0.0
 Identities = 977/977 (100%), Positives = 977/977 (100%)

Query: 1   MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60
           MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS
Sbjct: 1   MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60

Query: 61  CTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVP 120
           CTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVP
Sbjct: 61  CTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVP 120

Query: 121 QPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDS 180
           QPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDS
Sbjct: 121 QPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDS 180

Query: 181 PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPH 240
           PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPH
Sbjct: 181 PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPH 240

Query: 241 PVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKK 300
           PVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKK
Sbjct: 241 PVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKK 300

Query: 301 RRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDME 360
           RRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDME
Sbjct: 301 RRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDME 360

Query: 361 LARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQ 420
           LARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQ
Sbjct: 361 LARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQ 420

Query: 421 SPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP 480
           SPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP
Sbjct: 421 SPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP 480

Query: 481 TTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRS 540
           TTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRS
Sbjct: 481 TTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRS 540

Query: 541 SGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPG 600
           SGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPG
Sbjct: 541 SGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPG 600

Query: 601 PGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLD 660
           PGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLD
Sbjct: 601 PGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLD 660

Query: 661 EKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPK 720
           EKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPK
Sbjct: 661 EKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPK 720

Query: 721 TPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP 780
           TPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP
Sbjct: 721 TPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP 780

Query: 781 GLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840
           GLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP
Sbjct: 781 GLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840

Query: 841 KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAE 900
           KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAE
Sbjct: 841 KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAE 900

Query: 901 PLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSA 960
           PLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSA
Sbjct: 901 PLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSA 960

Query: 961 TRTGLQAHVWRPGAGHQ 977
           TRTGLQAHVWRPGAGHQ
Sbjct: 961 TRTGLQAHVWRPGAGHQ 977


>gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]
          Length = 753

 Score = 1460 bits (3780), Expect = 0.0
 Identities = 725/739 (98%), Positives = 727/739 (98%), Gaps = 6/739 (0%)

Query: 239 PHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF 298
           P PV E       Q +  A+LQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF
Sbjct: 21  PDPVPE------LQDSFYAELQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF 74

Query: 299 KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 358
           KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD
Sbjct: 75  KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 134

Query: 359 MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 418
           MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG
Sbjct: 135 MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 194

Query: 419 LQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQ 478
           LQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQ
Sbjct: 195 LQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQ 254

Query: 479 RPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTP 538
           RPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTP
Sbjct: 255 RPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTP 314

Query: 539 RSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPA 598
           RSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPA
Sbjct: 315 RSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPA 374

Query: 599 PGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQN 658
           PGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQN
Sbjct: 375 PGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQN 434

Query: 659 LDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMT 718
           LDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMT
Sbjct: 435 LDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMT 494

Query: 719 PKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTP 778
           PKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTP
Sbjct: 495 PKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTP 554

Query: 779 GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRA 838
           GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRA
Sbjct: 555 GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRA 614

Query: 839 TPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPT 898
           TPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPT
Sbjct: 615 TPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPT 674

Query: 899 AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRF 958
           AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRF
Sbjct: 675 AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRF 734

Query: 959 SATRTGLQAHVWRPGAGHQ 977
           SATRTGLQAHVWRPGAGHQ
Sbjct: 735 SATRTGLQAHVWRPGAGHQ 753



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 149/612 (24%), Positives = 206/612 (33%), Gaps = 124/612 (20%)

Query: 92  PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG---- 147
           P    +P E  VL P    SP P     P+P QPG     P    +         G    
Sbjct: 199 PRAQSAPPEAAVLPP----SPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQ 254

Query: 148 -PATQE---KPRRPRRR----GPTRPTPP---------------GAPPDEVYLSDSPAEP 184
            P T     +P  P+R     G   P PP                  P    +S SP+ P
Sbjct: 255 RPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTP 314

Query: 185 APTIPGPPSQGDS----RVSSPSWEDGAALQPPPAEALLLP-------HGPLRPGPH-LI 232
             +  GP +   S      S P    GA   P P  A  +          PLRP      
Sbjct: 315 RSS--GPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEA 372

Query: 233 PMVGP-VPHPVAEDLTTTYTQKAKQAKLQ--RAESLQEKSIKEAKTKCRTIASLLTAAPN 289
           P  GP  P P +          A+   LQ  R    +++  +  K + +        +PN
Sbjct: 373 PAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN-------SPN 425

Query: 290 PHSKGVLMFKKRRQRA------KKYTLVSFGAAA-----GTGAEEEDGVPPTSESELDEE 338
           P    ++     + RA       +   +S GA A       GA     +P  +       
Sbjct: 426 PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 485

Query: 339 AFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE---VSGRGVQLFEQQR 395
           A      +T ++    P +  +    G       G+     + E   + GRG +LF +++
Sbjct: 486 APKTPPPMTPKT---PPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQ 542

Query: 396 QRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAP-VASPRPFQPGG 454
            RAD    E           G GL   PR+ S  P    LPPS   +P + +P P     
Sbjct: 543 SRADRYVVE--------GTPGPGLGPRPRSPSPTPS---LPPSWKYSPNIRAPPPI---- 587

Query: 455 GAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQG 514
            A  P  S F   A    P  Q Q P  T        PK+   +L  +   P      Q 
Sbjct: 588 -AYNPLLSPFFPQAARTLPKAQSQGPRAT--------PKQGIKALDFMRHQP-----YQL 633

Query: 515 PTPLPSFTSGVPSHAPV-SGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSA 573
            T +  F    P+  P+ SGSP T R            +    R  TP  AP+P A P A
Sbjct: 634 KTAMFCFDEVPPTPGPIASGSPKTAR------------VQEIRRFSTP--APQPTAEPLA 679

Query: 574 -AAMTSTASIFLSAPL----RPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEAR 628
              +   A+  L  P+      SA   +PAP P AP    A         AR      A 
Sbjct: 680 PTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRF--SAT 737

Query: 629 RRGTRKQMFRPG 640
           R G +  ++RPG
Sbjct: 738 RTGLQAHVWRPG 749


>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score =  349 bits (895), Expect = 8e-96
 Identities = 290/832 (34%), Positives = 389/832 (46%), Gaps = 189/832 (22%)

Query: 244  EDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQ 303
            +D +  +  +A+ A+L+R+ESL EK +KEAK+KC++IA LLT APNP+SKGVLMFKKRR+
Sbjct: 343  KDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRR 402

Query: 304  RAKKYTLVSFGAA--AGTGAEEEDGVPP---------TSESELDEEAFSDARSLTN--QS 350
            RA+KYTLVS+G         EEE+G             SESE+DEE  SD    T     
Sbjct: 403  RARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNF 462

Query: 351  DWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL----- 405
            DWDS  +D+E      + + G    +   L + +G+G  +F ++R+R D  T +      
Sbjct: 463  DWDSGLVDIE-----KKLNRGDKMEM---LPDTTGKGALMFAKRRERMDQITAQKEEDKV 514

Query: 406  ----ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPR-----PFQPGGGA 456
                +R + AA    +GL++    Q    E+     S   + +         P Q G   
Sbjct: 515  GGTPSREQDAAQT--DGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSG 572

Query: 457  PTPAPSI-----FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
             +   +I      NR+A+PF PG   Q  T       P +P R   S     PAPPP+ S
Sbjct: 573  TSETANIQRMVPMNRTAKPF-PGSVNQPAT-------PFSPTRNMTSPIADFPAPPPY-S 623

Query: 512  SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            +  P P  +F+ GV S  P++G    P              P P            PAP 
Sbjct: 624  AVTPPP-DAFSRGVSS--PIAGPAQPP--------------PWPQ-----------PAPW 655

Query: 572  SAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRG 631
            S  A   ++                        E  ++R++RISVPA RTGILQEA+RR 
Sbjct: 656  SQPAFYDSS------------------------ERIASRDERISVPAKRTGILQEAKRRS 691

Query: 632  TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG-GAESGPEEDALSLGAEACNFMQPV 690
            T K MF    +E K SPNPELLSL+QN + K   G G +SGPEED LSLGAEACNFMQ  
Sbjct: 692  TTKPMFT--FKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSS 749

Query: 691  GARSYKTLPHVTPKTPPPMAPK------TPPPMTPKTP---PPVAPK------------- 728
             A+          KTPPP+APK      +  P+TP +P   P VAP              
Sbjct: 750  SAKQ---------KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800

Query: 729  -------------PPSR--------GLLDGLVNGAASSAGIPEP---------------- 751
                         PP+R        G   G     AS    P+P                
Sbjct: 801  TVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVG 860

Query: 752  -----PRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIR 806
                 P + GRG +LFAKRQSR ++YVV+           R+ SPTPSLP SWKYS N+R
Sbjct: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ--AHAARAQSPTPSLPASWKYSSNVR 918

Query: 807  APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQG---IKALDFMRHQPYQLKTAMFC 863
            APPP+AYNP+ SP +P AA     + +Q  +   K+G   + ALD M+HQPYQL  ++F 
Sbjct: 919  APPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFT 978

Query: 864  FDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTE 923
            F       G     S K      +++   P P   A P      +  +      P     
Sbjct: 979  FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFA 1038

Query: 924  LASAPV---PSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 972
             AS+PV   P P   P +P+    S SS  F   RP+FSA ++G+   VW+P
Sbjct: 1039 EASSPVSASPVPVGIPTSPK--QESASSSYFVAPRPKFSAKKSGVTIQVWKP 1088



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 36/86 (41%), Positives = 63/86 (73%)

Query: 1  MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60
          MG  + + ++++GGAPWGFRL GG EQ++PLQV+KIR +S+A  +GL E D++++ING  
Sbjct: 1  MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61 CTNLSHASAMSLIDASGNQLVLTVQR 86
          C +L++   + L+++  + L + ++R
Sbjct: 61 CADLTYPEVIKLMESITDSLQMLIKR 86



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 80/352 (22%), Positives = 124/352 (35%), Gaps = 51/352 (14%)

Query: 181  PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLP---------------HGPL 225
            P  P P +    SQ  + VS P W  G A   PPA     P               + P 
Sbjct: 758  PVAPKPAVKSSSSQPVTPVS-PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPA 816

Query: 226  RPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLT 285
            RP   L  + GP   P A   +  YT K          ++Q  ++  +            
Sbjct: 817  RPASTL-NVAGPFKGPQAAVASQNYTPK-PTVSTPTVNAVQPGAVGPS-----------N 863

Query: 286  AAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARS 345
              P    +G  +F KR+ R +KY + S    A     +     PT       +  S+ R+
Sbjct: 864  ELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQS----PTPSLPASWKYSSNVRA 919

Query: 346  LTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL 405
                +          LA   S+ S  Q S +G +  +     + + + Q  + ++S   L
Sbjct: 920  PPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNAS---L 976

Query: 406  ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA----P 461
               +P    +G   +S  +  SA      LPP P+ A  ASP   Q       PA    P
Sbjct: 977  FTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNA--ASPTNVQASSVYSVPAYTSPP 1034

Query: 462  SIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQ 513
            S F  ++ P +       P    +   P +PK+ + S      AP P  S++
Sbjct: 1035 SFFAEASSPVSAS-----PVPVGI---PTSPKQESAS-SSYFVAPRPKFSAK 1077


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score =  341 bits (875), Expect = 2e-93
 Identities = 288/829 (34%), Positives = 386/829 (46%), Gaps = 189/829 (22%)

Query: 244  EDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQ 303
            +D +  +  +A+ A+L+R+ESL EK +KEAK+KC++IA LLT APNP+SKGVLMFKKRR+
Sbjct: 343  KDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRR 402

Query: 304  RAKKYTLVSFGAA--AGTGAEEEDGVPP---------TSESELDEEAFSDARSLTN--QS 350
            RA+KYTLVS+G         EEE+G             SESE+DEE  SD    T     
Sbjct: 403  RARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNF 462

Query: 351  DWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL----- 405
            DWDS  +D+E      + + G    +   L + +G+G  +F ++R+R D  T +      
Sbjct: 463  DWDSGLVDIE-----KKLNRGDKMEM---LPDTTGKGALMFAKRRERMDQITAQKEEDKV 514

Query: 406  ----ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPR-----PFQPGGGA 456
                +R + AA    +GL++    Q    E+     S   + +         P Q G   
Sbjct: 515  GGTPSREQDAAQT--DGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSG 572

Query: 457  PTPAPSI-----FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
             +   +I      NR+A+PF PG   Q  T       P +P R   S     PAPPP+ S
Sbjct: 573  TSETANIQRMVPMNRTAKPF-PGSVNQPAT-------PFSPTRNMTSPIADFPAPPPY-S 623

Query: 512  SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            +  P P  +F+ GV S  P++G    P              P P            PAP 
Sbjct: 624  AVTPPP-DAFSRGVSS--PIAGPAQPP--------------PWPQ-----------PAPW 655

Query: 572  SAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRG 631
            S  A   ++                        E  ++R++RISVPA RTGILQEA+RR 
Sbjct: 656  SQPAFYDSS------------------------ERIASRDERISVPAKRTGILQEAKRRS 691

Query: 632  TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG-GAESGPEEDALSLGAEACNFMQPV 690
            T K MF    +E K SPNPELLSL+QN + K   G G +SGPEED LSLGAEACNFMQ  
Sbjct: 692  TTKPMFT--FKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSS 749

Query: 691  GARSYKTLPHVTPKTPPPMAPK------TPPPMTPKTP---PPVAPK------------- 728
             A+          KTPPP+APK      +  P+TP +P   P VAP              
Sbjct: 750  SAKQ---------KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800

Query: 729  -------------PPSR--------GLLDGLVNGAASSAGIPEP---------------- 751
                         PP+R        G   G     AS    P+P                
Sbjct: 801  TVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVG 860

Query: 752  -----PRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIR 806
                 P + GRG +LFAKRQSR ++YVV+           R+ SPTPSLP SWKYS N+R
Sbjct: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ--AHAARAQSPTPSLPASWKYSSNVR 918

Query: 807  APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQG---IKALDFMRHQPYQLKTAMFC 863
            APPP+AYNP+ SP +P AA     + +Q  +   K+G   + ALD M+HQPYQL  ++F 
Sbjct: 919  APPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFT 978

Query: 864  FDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTE 923
            F       G     S K      +++   P P   A P      +  +      P     
Sbjct: 979  FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFA 1038

Query: 924  LASAPV---PSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHV 969
             AS+PV   P P   P +P+    S SS  F   RP+FSA ++G+   V
Sbjct: 1039 EASSPVSASPVPVGIPTSPK--QESASSSYFVAPRPKFSAKKSGVTIQV 1085



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 36/86 (41%), Positives = 63/86 (73%)

Query: 1  MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60
          MG  + + ++++GGAPWGFRL GG EQ++PLQV+KIR +S+A  +GL E D++++ING  
Sbjct: 1  MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61 CTNLSHASAMSLIDASGNQLVLTVQR 86
          C +L++   + L+++  + L + ++R
Sbjct: 61 CADLTYPEVIKLMESITDSLQMLIKR 86



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 83/367 (22%), Positives = 128/367 (34%), Gaps = 51/367 (13%)

Query: 181  PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLP---------------HGPL 225
            P  P P +    SQ  + VS P W  G A   PPA     P               + P 
Sbjct: 758  PVAPKPAVKSSSSQPVTPVS-PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPA 816

Query: 226  RPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLT 285
            RP   L  + GP   P A   +  YT K          ++Q  ++  +            
Sbjct: 817  RPASTL-NVAGPFKGPQAAVASQNYTPK-PTVSTPTVNAVQPGAVGPS-----------N 863

Query: 286  AAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARS 345
              P    +G  +F KR+ R +KY + S    A     +     PT       +  S+ R+
Sbjct: 864  ELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQS----PTPSLPASWKYSSNVRA 919

Query: 346  LTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL 405
                +          LA   S+ S  Q S +G +  +     + + + Q  + ++S   L
Sbjct: 920  PPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNAS---L 976

Query: 406  ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA----P 461
               +P    +G   +S  +  SA      LPP P+ A  ASP   Q       PA    P
Sbjct: 977  FTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNA--ASPTNVQASSVYSVPAYTSPP 1034

Query: 462  SIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLG-GLSPAPPPFLSSQGPTPLPS 520
            S F  ++ P +       P    +   P +PK+ + S    ++P P       G T    
Sbjct: 1035 SFFAEASSPVSAS-----PVPVGI---PTSPKQESASSSYFVAPRPKFSAKKSGVTIQVK 1086

Query: 521  FTSGVPS 527
              SG+ S
Sbjct: 1087 CKSGIHS 1093


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score =  340 bits (873), Expect = 3e-93
 Identities = 287/825 (34%), Positives = 385/825 (46%), Gaps = 189/825 (22%)

Query: 244  EDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQ 303
            +D +  +  +A+ A+L+R+ESL EK +KEAK+KC++IA LLT APNP+SKGVLMFKKRR+
Sbjct: 343  KDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRR 402

Query: 304  RAKKYTLVSFGAA--AGTGAEEEDGVPP---------TSESELDEEAFSDARSLTN--QS 350
            RA+KYTLVS+G         EEE+G             SESE+DEE  SD    T     
Sbjct: 403  RARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNF 462

Query: 351  DWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL----- 405
            DWDS  +D+E      + + G    +   L + +G+G  +F ++R+R D  T +      
Sbjct: 463  DWDSGLVDIE-----KKLNRGDKMEM---LPDTTGKGALMFAKRRERMDQITAQKEEDKV 514

Query: 406  ----ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPR-----PFQPGGGA 456
                +R + AA    +GL++    Q    E+     S   + +         P Q G   
Sbjct: 515  GGTPSREQDAAQT--DGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSG 572

Query: 457  PTPAPSI-----FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
             +   +I      NR+A+PF PG   Q  T       P +P R   S     PAPPP+ S
Sbjct: 573  TSETANIQRMVPMNRTAKPF-PGSVNQPAT-------PFSPTRNMTSPIADFPAPPPY-S 623

Query: 512  SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            +  P P  +F+ GV S  P++G    P              P P            PAP 
Sbjct: 624  AVTPPP-DAFSRGVSS--PIAGPAQPP--------------PWPQ-----------PAPW 655

Query: 572  SAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRG 631
            S  A   ++                        E  ++R++RISVPA RTGILQEA+RR 
Sbjct: 656  SQPAFYDSS------------------------ERIASRDERISVPAKRTGILQEAKRRS 691

Query: 632  TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG-GAESGPEEDALSLGAEACNFMQPV 690
            T K MF    +E K SPNPELLSL+QN + K   G G +SGPEED LSLGAEACNFMQ  
Sbjct: 692  TTKPMFT--FKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSS 749

Query: 691  GARSYKTLPHVTPKTPPPMAPK------TPPPMTPKTP---PPVAPK------------- 728
             A+          KTPPP+APK      +  P+TP +P   P VAP              
Sbjct: 750  SAKQ---------KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800

Query: 729  -------------PPSR--------GLLDGLVNGAASSAGIPEP---------------- 751
                         PP+R        G   G     AS    P+P                
Sbjct: 801  TVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVG 860

Query: 752  -----PRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIR 806
                 P + GRG +LFAKRQSR ++YVV+           R+ SPTPSLP SWKYS N+R
Sbjct: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ--AHAARAQSPTPSLPASWKYSSNVR 918

Query: 807  APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQG---IKALDFMRHQPYQLKTAMFC 863
            APPP+AYNP+ SP +P AA     + +Q  +   K+G   + ALD M+HQPYQL  ++F 
Sbjct: 919  APPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFT 978

Query: 864  FDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTE 923
            F       G     S K      +++   P P   A P      +  +      P     
Sbjct: 979  FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFA 1038

Query: 924  LASAPV---PSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGL 965
             AS+PV   P P   P +P+    S SS  F   RP+FSA ++G+
Sbjct: 1039 EASSPVSASPVPVGIPTSPK--QESASSSYFVAPRPKFSAKKSGV 1081



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 36/86 (41%), Positives = 63/86 (73%)

Query: 1  MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60
          MG  + + ++++GGAPWGFRL GG EQ++PLQV+KIR +S+A  +GL E D++++ING  
Sbjct: 1  MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61 CTNLSHASAMSLIDASGNQLVLTVQR 86
          C +L++   + L+++  + L + ++R
Sbjct: 61 CADLTYPEVIKLMESITDSLQMLIKR 86



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 121/552 (21%), Positives = 190/552 (34%), Gaps = 88/552 (15%)

Query: 181  PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLP---------------HGPL 225
            P  P P +    SQ  + VS P W  G A   PPA     P               + P 
Sbjct: 758  PVAPKPAVKSSSSQPVTPVS-PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPA 816

Query: 226  RPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLT 285
            RP   L  + GP   P A   +  YT K          ++Q  ++  +            
Sbjct: 817  RPASTL-NVAGPFKGPQAAVASQNYTPK-PTVSTPTVNAVQPGAVGPS-----------N 863

Query: 286  AAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARS 345
              P    +G  +F KR+ R +KY + S    A     +     PT       +  S+ R+
Sbjct: 864  ELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQS----PTPSLPASWKYSSNVRA 919

Query: 346  LTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL 405
                +          LA   S+ S  Q S +G +  +     + + + Q  + ++S   L
Sbjct: 920  PPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNAS---L 976

Query: 406  ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA----P 461
               +P    +G   +S  +  SA      LPP P+ A  ASP   Q       PA    P
Sbjct: 977  FTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNA--ASPTNVQASSVYSVPAYTSPP 1034

Query: 462  SIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSF 521
            S F  ++ P +       P    +   P +PK+ + S            SS    P P F
Sbjct: 1035 SFFAEASSPVSAS-----PVPVGI---PTSPKQESAS------------SSYFVAPRPKF 1074

Query: 522  T---SGVPSHAPVSGSPSTPRSSGPVTATSS-LYIPAPSRPVTPGG----APEPPAPPSA 573
            +   SGV             RS  P  +TS  +Y P  S    P      A + P P  A
Sbjct: 1075 SAKKSGVTIQESGRSLSLPGRSVPPPISTSPWVYQPTYSYSSKPTDGLEKANKRPTPWEA 1134

Query: 574  AAMTSTASI---FLSAPLRPS--ARPEAPAPGPGAPEPPSAREQRIS-VPAARTGILQEA 627
            AA +    +   F    ++ S  A   + A     P PP    +R+S +P  +       
Sbjct: 1135 AAKSPLGLVDDAFQPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQ------- 1187

Query: 628  RRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM 687
                 +  M   G++E   + N  + +  Q   + P A   ++   + A+       ++ 
Sbjct: 1188 -----KAYMGSCGRQEYNVTANNNMSTTSQYGSQLPYAYYRQASRNDSAIMSMETRSDYC 1242

Query: 688  QPVGARSYKTLP 699
             PV   +Y   P
Sbjct: 1243 LPVADYNYNPHP 1254


>gi|158303333 synaptopodin isoform B [Homo sapiens]
          Length = 685

 Score =  154 bits (390), Expect = 3e-37
 Identities = 156/518 (30%), Positives = 216/518 (41%), Gaps = 76/518 (14%)

Query: 461 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 519
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286

Query: 520 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 579
              S  P          +P S                RP+  G    PP      +    
Sbjct: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330

Query: 580 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 638
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381

Query: 639 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440

Query: 698 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 757
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479

Query: 758 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 816
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534

Query: 817 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 874
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586

Query: 875 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646

Query: 935 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 972
           P    R      S    Q  RP FS    G++A VW+P
Sbjct: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQVWKP 680



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 124/549 (22%), Positives = 185/549 (33%), Gaps = 81/549 (14%)

Query: 68  SAMSLIDASGNQLVLTVQ-----RLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQP 122
           S+  LID   N LV++       R A   P +  S     +  P S ++       +  P
Sbjct: 189 SSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP 248

Query: 123 LQPGSL-RSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSP 181
                + RSP     ++GE       P+  ++  RP+R   +R               S 
Sbjct: 249 GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE 308

Query: 182 AEPAPTIPGPPSQGDSRVSSP--SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239
             P      PP+  ++  ++P  SW     ++ PP+ ++L P    +   HL        
Sbjct: 309 RRPLGNFTAPPTYTETLSTAPLASW-----VRSPPSYSVLYPSSDPKSS-HL-------- 354

Query: 240 HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCR-TIASLLTAAPNPHSKGVLMF 298
                        K +     +   L+E   +    K   T        PNP    ++  
Sbjct: 355 -------------KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401

Query: 299 --KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAF-----SDARSLTNQSD 351
             +KRRQR +             G EEE        S   +E       S A +     +
Sbjct: 402 ADEKRRQRDQ----------GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPE 451

Query: 352 WDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQR-------ADSSTQE 404
           W S  L     +A  +    Q       LSE SG+G +L+ +++ R       + S T E
Sbjct: 452 WAS-CLKSPRIQAKPKPKPNQN------LSEASGKGAELYARRQSRMEKYVIESSSHTPE 504

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS-PRPFQPGGGAPTPAPSI 463
           LAR     M      + P    +AP    V   SP   P AS    + P  G   P P+ 
Sbjct: 505 LARCPSPTMSLPSSWKYP---TNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPT- 560

Query: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523
             +      P L    P        P A   A  S   L P  P     +G  P PS   
Sbjct: 561 -KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-----KGALP-PSPAL 613

Query: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583
             PS +      S  + S   TA S  Y      PV+P  A  P A  +     ST +  
Sbjct: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPY-GGDISPVSPSRAWSPRAKQAPRPSFSTRNAG 672

Query: 584 LSAPL-RPS 591
           + A + +PS
Sbjct: 673 IEAQVWKPS 681


>gi|40353727 synaptopodin isoform A [Homo sapiens]
          Length = 903

 Score =  147 bits (370), Expect = 6e-35
 Identities = 157/530 (29%), Positives = 216/530 (40%), Gaps = 86/530 (16%)

Query: 461 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 519
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286

Query: 520 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 579
              S  P          +P S                RP+  G    PP      +    
Sbjct: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330

Query: 580 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 638
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381

Query: 639 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440

Query: 698 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 757
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479

Query: 758 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 816
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534

Query: 817 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 874
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586

Query: 875 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646

Query: 935 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAH----------VWRPGA 974
           P    R      S    Q  RP FS    G++A            W PGA
Sbjct: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGA 692



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 178/777 (22%), Positives = 256/777 (32%), Gaps = 142/777 (18%)

Query: 68  SAMSLIDASGNQLVLTVQ-----RLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQP 122
           S+  LID   N LV++       R A   P +  S     +  P S ++       +  P
Sbjct: 189 SSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP 248

Query: 123 LQPGSL-RSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSP 181
                + RSP     ++GE       P+  ++  RP+R   +R               S 
Sbjct: 249 GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE 308

Query: 182 AEPAPTIPGPPSQGDSRVSSP--SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239
             P      PP+  ++  ++P  SW     ++ PP+ ++L P    +   HL        
Sbjct: 309 RRPLGNFTAPPTYTETLSTAPLASW-----VRSPPSYSVLYPSSDPKSS-HL-------- 354

Query: 240 HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCR-TIASLLTAAPNPHSKGVLMF 298
                        K +     +   L+E   +    K   T        PNP    ++  
Sbjct: 355 -------------KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401

Query: 299 --KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAF-----SDARSLTNQSD 351
             +KRRQR +             G EEE        S   +E       S A +     +
Sbjct: 402 ADEKRRQRDQ----------GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPE 451

Query: 352 WDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRAD-------SSTQE 404
           W S  L     +A  +    Q       LSE SG+G +L+ +++ R +       S T E
Sbjct: 452 WAS-CLKSPRIQAKPKPKPNQN------LSEASGKGAELYARRQSRMEKYVIESSSHTPE 504

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASP-RPFQPGGGAPTPAPSI 463
           LAR     M      + P    +AP    V   SP   P AS    + P  G   P P+ 
Sbjct: 505 LARCPSPTMSLPSSWKYPT---NAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPT- 560

Query: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523
             +      P L    P        P A   A  S   L P  P     +G  P PS   
Sbjct: 561 -KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-----KGALP-PSPAL 613

Query: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583
             PS +      S  + S   TA S  Y      PV+P  A  P A  +     ST +  
Sbjct: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPY-GGDISPVSPSRAWSPRAKQAPRPSFSTRNAG 672

Query: 584 LSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEE 643
           + A  R  + P +P   PGA  PPS+ +  +S                     + PG+  
Sbjct: 673 IEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGP------------------WEPGRGS 714

Query: 644 TKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEA---CNFMQPVGARSYKTLPH 700
           + +SP P        L   P    + S      L    EA      +Q + AR+      
Sbjct: 715 SMSSPPP--------LPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAAR 766

Query: 701 VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGE 760
               +P     + P P +P   PP  P PP                  P PPR+      
Sbjct: 767 RKSASPRSAGAENPRPFSPPRAPPPPPPPP------------------PPPPRM------ 802

Query: 761 LFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLL 817
               R  +  R      PG    P PRSP P     PS   SP  R+P P    P L
Sbjct: 803 ----RSPQPARPGSAAVPGAAFAPIPRSPLPA---GPSSCTSP--RSPLPAPPRPFL 850



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 138/623 (22%), Positives = 207/623 (33%), Gaps = 159/623 (25%)

Query: 442 APVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
           +P+   R F     AP P PS+ +RS RP    +  + P     +    +P      LG 
Sbjct: 257 SPMLERRHFGEKAPAPQP-PSLPDRSPRP-QRHIMSRSPMVERRMMGQRSPASERRPLGN 314

Query: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPV--SGSPSTPRSSG---PVTATS-------- 548
            + APP +  +    PL S+    PS++ +  S  P +    G   P + T         
Sbjct: 315 FT-APPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMAR 373

Query: 549 -----SLYIPAPSRPVTPG----------------------GAPEPPAPPSAAAMTSTAS 581
                S++       VTP                       G  E P      A+ + AS
Sbjct: 374 RGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPF-----ALGAEAS 428

Query: 582 IFLSAPLRPSARPEAPAPGPGAPE-------------PPSAREQRISVPAARTGILQEAR 628
            F   P  P  R    A     PE             P     Q +S  + +   L   R
Sbjct: 429 NFQQEPA-PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARR 487

Query: 629 RRGTRKQMFRPGKE--ETKNSPNPELLSLVQNLDEKPRAGGA-ESGPEEDALSLGAEACN 685
           +    K +        E    P+P + SL  +      A GA        A +  A   +
Sbjct: 488 QSRMEKYVIESSSHTPELARCPSPTM-SLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546

Query: 686 FMQPVGARSYKTLPHVTPKTPPPMAP--------KTPPPMTPKTPPPVAPKPPSRGLLDG 737
              P         P  T + P  + P        K P  ++P+   P   KP S  L+  
Sbjct: 547 GYLPENG---VLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPA--KPSSLDLVPN 601

Query: 738 LVNGAAS-SAGIPEPPR-------------LQGR------GGELFAKRQSRADRYVVEGT 777
           L  GA   S  +P P R             LQ        GG++     SRA     +  
Sbjct: 602 LPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQA 661

Query: 778 PGPGLGPR-------------PRSPSPTP--SLPPS----------WK--YSPNIRAPPP 810
           P P    R             P SP  TP  S PPS          W+     ++ +PPP
Sbjct: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP 721

Query: 811 IAYNPLLSPFFPQAARTLPKAQSQG-PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869
           +   P +SP + + + +  + +++  P +   Q + A + +     +             
Sbjct: 722 LPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRK------------- 768

Query: 870 TPGPIASGSPKTARVQEIRRFS---TPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELAS 926
                 S SP++A  +  R FS    P P P   P  P + +P+ A        R   A+
Sbjct: 769 ------SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA--------RPGSAA 814

Query: 927 APVPSPAPPPEAPRGLGASPSSC 949
            P  + AP P +P  L A PSSC
Sbjct: 815 VPGAAFAPIPRSP--LPAGPSSC 835



 Score = 37.0 bits (84), Expect = 0.090
 Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 13/115 (11%)

Query: 94  QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEK 153
           +S SP      +P     P  P  P P P  P  +RSP  +        +   G A    
Sbjct: 768 KSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPAR----PGSAAVPGAAFAPI 823

Query: 154 PRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208
           PR P   GP+  T P +P         PA P P +    S  DS VS  S + GA
Sbjct: 824 PRSPLPAGPSSCTSPRSP--------LPAPPRPFL-YRRSPTDSDVSLDSEDSGA 869


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  115 bits (287), Expect = 3e-25
 Identities = 240/994 (24%), Positives = 329/994 (33%), Gaps = 183/994 (18%)

Query: 106  PLSPLSPEPPGA-----------PVPQPLQ--PGSLRSPPDSEAYYGETDSDADG--PAT 150
            P+SP  P+P              P  + LQ  P SL   P S A  G T        P  
Sbjct: 504  PVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLV 563

Query: 151  QEKPRRPRRRGPTRPTPP-GAPPDEVYLSDSPAEPAPTIPGPPSQGDSRV---SSPSWED 206
            Q  P+       T  +P     P+      S  EP P I  P S   S +   SS S   
Sbjct: 564  QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLP-IGKPASSMTSPLGVNSSASVIK 622

Query: 207  GAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDL---TTTYTQKAKQAKLQRAE 263
              +   P +   LL    + P     P+    P  VA      T+TYT  A    L+   
Sbjct: 623  TDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPF-LEGTV 681

Query: 264  SLQEKSIKEAKTKCRTIASLLTA------APNPHSK-----GVLMFKKRRQRAKKYTLVS 312
            SL  K+    +    T+  + TA      AP+P +       +++  +  +     +L  
Sbjct: 682  SLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPP 741

Query: 313  FGAAAGT----GAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAG--- 365
             G   GT    G      + P + S  +        S T  S     YL    +  G   
Sbjct: 742  AGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSV 801

Query: 366  ---------SRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNG 416
                      + S G  + +G   S VS        +       S    A        + 
Sbjct: 802  SPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSP 861

Query: 417  EGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQ---PGGGAPTPAPSIFNRSARP--- 470
            +G  +P       P+   LPP   P P     PF    P   AP  AP++   S+ P   
Sbjct: 862  KGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKA 921

Query: 471  -FTPGLQGQRPTTTSVIFRPLAPKRANDSLGG--LSPAP-----PPFLSSQGP-----TP 517
              TP  +G  P + S    P  P     S  G   +P+P     PP  +   P     TP
Sbjct: 922  RATPAPKGI-PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATP 980

Query: 518  LPSFTSGVPSHAPVS--GSPSTPRSSG---PVTATSSLYIPAPSRPVTPGGAPEPPA--P 570
             P      P+  P S  G P+TP   G   P   T      +P+    P GA  PPA  P
Sbjct: 981  SPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATP 1040

Query: 571  PSAAAMTSTASIFLSAPLRPSARPEAPAPGP------GAPEPPSAREQR----------- 613
            PS     +   +   AP  P+A   +P  GP      GAP PP+A               
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100

Query: 614  ------ISVPAARTGILQEARRRG--TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRA 665
                   + P +  G L     +G  T      P  +    +P P+              
Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 666  GGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTP--PPMAPK----TPPPMTP 719
            GG  + P + A +    A     P G  +  + P   P TP   P +PK    TP P   
Sbjct: 1161 GGLATPPPKGAPT--TPAATPPSPKGGLATPS-PKGAPTTPAATPPSPKGGLATPSPKGA 1217

Query: 720  KTPPPVAPKPPSRGLLDGLVNGAASS-----------------AGIPEPPRLQG---RGG 759
             T P   P  P  GL      GA ++                  G P PP       +GG
Sbjct: 1218 PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGG 1277

Query: 760  ELFAKRQSRADRYVVEGTP-----GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYN 814
                  +   +  VV  TP     GP   P   +P+P  + PPS K SP    P      
Sbjct: 1278 LATPPHKGAPNPAVV--TPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTP 1335

Query: 815  PLLSPFFPQAARTLPKA--QSQGPRATP--KQGIKALDFMRHQPYQLKTAMFCFDEVPPT 870
            P ++P  P+   TLP     S+G   TP  K+G                        PP 
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEG----------------------PTPPA 1373

Query: 871  PGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTV--LAPRAATTLDEPIWRTELA--- 925
              P   G P  A      +     P P  +P +P V  L+P+ A     P+ R   A   
Sbjct: 1374 ATPSHKGGP--AMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPA--TPVTREGAATPS 1429

Query: 926  ----SAPVPSP-----APPPEAPRGLGASPSSCG 950
                + P  +P     AP   AP+G  A+PSS G
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKG 1463



 Score =  109 bits (273), Expect = 1e-23
 Identities = 218/916 (23%), Positives = 303/916 (33%), Gaps = 103/916 (11%)

Query: 90   EGPVQSPSPHELQVLSPLS---------------PLSPEPPGAPVPQPLQPGSLRSPPDS 134
            EGP  +P+P +   LS  S               P SP P GAP P    P S +  P +
Sbjct: 898  EGPA-TPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPAT 956

Query: 135  EA-YYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEP----APTIP 189
             +  +  T   A  P+ +  P  P  +G   PTPP A P        PA P    APT P
Sbjct: 957  PSPKWAPTPPAATPPSPKGGPATPSPKGA--PTPPAATPPSP--KGGPATPSPKGAPTPP 1012

Query: 190  G--PPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLT 247
               PPS   S  ++P +  GA+   PPA     P G     P   P+    P   A  L 
Sbjct: 1013 AVTPPSPKGSPAATP-FPKGAST--PPAATPPSPKG----SPAATPLPKGAPTTPAATLP 1065

Query: 248  TTY----TQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQ 303
            +      T   K A    A +        A T     A +  AA  P  KG L     + 
Sbjct: 1066 SPKGGPATPSLKGAPTPPAATPPSPKGGPA-TPSPKGAPMPPAATPPSPKGGLATPPHKG 1124

Query: 304  RAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELAR 363
                          G       G P T  +         A      +   +P       +
Sbjct: 1125 APTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAP-TTPAATPPSPK 1183

Query: 364  AGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPP 423
             G      +G+      +  S +G          A  S +       A   + +G  + P
Sbjct: 1184 GGLATPSPKGAPTTPAATPPSPKG--------GLATPSPKGAPTTPAATPPSPKGGLATP 1235

Query: 424  RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARP----------FTP 473
              + AP   A  PPSP   P   P    P   A TP PS+    A P           TP
Sbjct: 1236 SPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP-PSLKGGLATPPHKGAPNPAVVTP 1294

Query: 474  GLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPT---PLPSFTSGVPSHAP 530
                  P T+     P  P     S  G    PPP  +   P    P P  T  +P+  P
Sbjct: 1295 PSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTP 1354

Query: 531  VS-GSPSTPRSSG---PVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSA 586
             S G P+TP S     P  AT S        P +P   P  P+P      TS A I    
Sbjct: 1355 SSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP--TSPAVI---- 1408

Query: 587  PLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN 646
            PL P   P  P    GA  P       ++ PA     L++A      K    P    +K 
Sbjct: 1409 PLSPKKAPATPVTREGAATPSKG---DLTPPAVTPVSLKKAPATSAPKG--GPATPSSKG 1463

Query: 647  SPN-PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKT 705
             P  P +          P+     S P++   +        +  V   S K +P      
Sbjct: 1464 DPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSR 1523

Query: 706  PPPMAPKTPPPMTPKTPPPVAPK----PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGEL 761
              P+AP T   ++ KTP  +APK    PP+       V     +  IP P          
Sbjct: 1524 RDPIAP-TATLLSKKTPATLAPKEALIPPAM-----TVPSPKKTPAIPTPKEAPATPSSK 1577

Query: 762  FAKRQSRADRYVVEGTPGPG--------LGPRPR-SPSPTPSLPPSWKYSPNIRAPPPIA 812
             A           +G P P           P P+ +P+P    PPS +  P   AP    
Sbjct: 1578 EASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTP 1637

Query: 813  YNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPG 872
             +P ++P   + + T P + +    AT  Q  K L   +  P  LK  +     V P P 
Sbjct: 1638 TSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLP-AKKGPTALKEVL-----VAPAPE 1691

Query: 873  PIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSP 932
                 +  T +  + ++ S  +P    +P A        +T    P+   +  S+     
Sbjct: 1692 STPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKG 1751

Query: 933  APPPEAPRGLGASPSS 948
                 +P+G  A P S
Sbjct: 1752 KDASHSPKGPLAPPES 1767



 Score =  100 bits (248), Expect = 9e-21
 Identities = 216/896 (24%), Positives = 291/896 (32%), Gaps = 144/896 (16%)

Query: 96   PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
            PSP      S ++PLSP+    P  +   P  +  P   E     T +    PA      
Sbjct: 859  PSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEG--PATPAPKQAPALSMTSS 916

Query: 156  RPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
             P++   T P P G P        +P  PA T P P  +G     SP W    A  PP A
Sbjct: 917  SPKKARAT-PAPKGIPASP-SPKGAPTPPAATPPSP--KGGPATPSPKW----APTPPAA 968

Query: 216  EALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKT 275
                   GP  P P   P       P  +    T + K   A    A +        A T
Sbjct: 969  TPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG--APTPPAVTPPSPKGSPAAT 1026

Query: 276  KCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESEL 335
                 AS   AA  P  K                    G+ A T   +  G P T  + L
Sbjct: 1027 PFPKGASTPPAATPPSPK--------------------GSPAATPLPK--GAPTTPAATL 1064

Query: 336  DEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQR 395
                   A      +    P       + G      +G+ +    +  S +G  L     
Sbjct: 1065 PSPKGGPATPSLKGAP-TPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG-GLATPPH 1122

Query: 396  QRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSP-----LPAPVASP--- 447
            + A ++        P +   G     P  A + P   A  PPSP      P P  +P   
Sbjct: 1123 KGAPTT----PAATPPSPKGGLATPPPKGAPTTP---AATPPSPKGGLATPPPKGAPTTP 1175

Query: 448  --RPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
               P  P GG  TP+P        P TP      P+    +  P +PK A  +     P+
Sbjct: 1176 AATPPSPKGGLATPSP-----KGAPTTPA--ATPPSPKGGLATP-SPKGAPTTPAATPPS 1227

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P   L++  P   P+  +  P      G P+TP   G  T       PA + P   GG  
Sbjct: 1228 PKGGLATPSPKGAPTTPAATPPSP--KGGPATPPPKGAPTP------PAATPPSLKGGLA 1279

Query: 566  EPP--APPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI 623
             PP    P+ A +T         P  P   P A +P  GAP PP+A       P +  G 
Sbjct: 1280 TPPHKGAPNPAVVT---------PPSPKGGP-ATSPPKGAPTPPAA------TPPSPKG- 1322

Query: 624  LQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEA 683
                           PG    K +P P  ++        P   G  + P     S G   
Sbjct: 1323 --------------SPGTPPPKGAPTPPAVT-------PPSPKGTPTLPATTPSSKGGPT 1361

Query: 684  CNFMQ-----PVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGL 738
                +     P    S+K  P +TP + P   P  P P    T P V P  P +     +
Sbjct: 1362 TPSSKEGPTPPAATPSHKGGPAMTPPS-PKRGPAIPSPKGDPTSPAVIPLSPKKAPATPV 1420

Query: 739  V-NGAAS-SAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPS---PTP 793
               GAA+ S G   PP +        + +++ A      G   P     P  P+   P+P
Sbjct: 1421 TREGAATPSKGDLTPPAVTP-----VSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSP 1475

Query: 794  SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQ 853
              PP+ K      +P      P      P  A TLP      P+  P     A    R  
Sbjct: 1476 KEPPAPKQVATSSSPKKAPATPA-----PMGAPTLPAVIPSSPKEVP-----ATPSSRRD 1525

Query: 854  PYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPA-PQPTAEPLAPT---VLAP 909
            P    TA     + P T  P  +  P    V   ++  TPA P P   P  P+     +P
Sbjct: 1526 PI-APTATLLSKKTPATLAPKEALIPPAMTVPSPKK--TPAIPTPKEAPATPSSKEASSP 1582

Query: 910  RAAT--TLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRT 963
             A T  T        EL   P  +   P EAP     +P S     A P    T T
Sbjct: 1583 PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPT 1638



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 217/921 (23%), Positives = 300/921 (32%), Gaps = 171/921 (18%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
            P  +P P      +P +   P P G+P   PL  G+  +P  +        S   GPAT 
Sbjct: 1023 PAATPFPKGAS--TPPAATPPSPKGSPAATPLPKGAPTTPAAT------LPSPKGGPATP 1074

Query: 152  EKPRRPR---------RRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQG--DSRVS 200
                 P          + GP  P+P GAP      + +P  P   +  PP +G   +  +
Sbjct: 1075 SLKGAPTPPAATPPSPKGGPATPSPKGAPMPP---AATPPSPKGGLATPPHKGAPTTPAA 1131

Query: 201  SPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
            +P    G    PPP  A   P     P P      G +  P  +   TT        K  
Sbjct: 1132 TPPSPKGGLATPPPKGAPTTP-AATPPSPK-----GGLATPPPKGAPTTPAATPPSPK-- 1183

Query: 261  RAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTG 320
                L   S K A T          AA  P  KG L     +               G  
Sbjct: 1184 --GGLATPSPKGAPTT--------PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLA 1233

Query: 321  AEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQL 380
                 G P T  +         A      +    P       + G      +G+     +
Sbjct: 1234 TPSPKGAPTTPAATPPSPKGGPATPPPKGAP-TPPAATPPSLKGGLATPPHKGAPNPAVV 1292

Query: 381  SEVSGRGVQLFEQQRQRADSSTQELARVEPAAML-NGEGLQSPPRAQSAPPEAAVLPPSP 439
            +  S +G            +S  + A   PAA   + +G    P  + AP   AV PPSP
Sbjct: 1293 TPPSPKGGPA---------TSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343

Query: 440  LPAPVASPRPFQPGGGAPTPA-----------------PSIFNRSAR--PFTPGLQGQRP 480
               P          GG  TP+                 P++   S +  P  P  +G  P
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGD-P 1402

Query: 481  TTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPL-PSFTSGVPSHAPVSGSPSTPR 539
            T+ +VI  PL+PK+A  +      A  P      P  + P      P+ +   G P+TP 
Sbjct: 1403 TSPAVI--PLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPS 1460

Query: 540  SSGPVT------------------ATSSLYIPAPSRPVTPGGAPEPPAP-PSAAAMTSTA 580
            S G  T                  ATSS    AP+ P  P GAP  PA  PS+       
Sbjct: 1461 SKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATP-APMGAPTLPAVIPSSPK----- 1514

Query: 581  SIFLSAPLRPSARPEAPAPGP---GAPEPPSAREQRISVPAARTGILQEARRRGTRKQMF 637
                  P  PS+R +  AP         P +   +   +P A T +    +         
Sbjct: 1515 ----EVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMT-VPSPKKTPAIPTPKE 1569

Query: 638  RPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
             P    +K + +P  ++        P        P+E    L   A     P   +   T
Sbjct: 1570 APATPSSKEASSPPAVT--------PSTYKGAPSPKE---LLIPPAVTSPSP---KEAPT 1615

Query: 698  LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSA--GIPEPPRLQ 755
             P VTP + P   P TP P    T PPV P      L D   + A+ +   G   P   +
Sbjct: 1616 PPAVTPPS-PEKGPATPAPKGTPTSPPVTPS----SLKDSPTSPASVTCKMGATVPQASK 1670

Query: 756  GRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNP 815
            G    L AK+   A + V+     P     P   +PT   P + K S      PPI  +P
Sbjct: 1671 G----LPAKKGPTALKEVL---VAPAPESTPIITAPTRKGPQTKKSS---ATSPPICPDP 1720

Query: 816  LLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIA 875
                          K  S+GP +T    +     +  Q    KTA           G  A
Sbjct: 1721 ------------SAKNGSKGPLST----VAPAPLLPVQKDSSKTA----------KGKDA 1754

Query: 876  SGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPP 935
            S SPK        + STP      E + P    P +A+    P     L  AP P P  P
Sbjct: 1755 SHSPKGPLAPPESKASTPLTAAAFEKVLP---KPESASVSAAPSPPVSLPLAPSPVPTLP 1811

Query: 936  PEAPRGLGASPSSCGFQVARP 956
            P+        PSS G  +  P
Sbjct: 1812 PKQQ----FLPSSPGLVLESP 1828



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 120/493 (24%), Positives = 189/493 (38%), Gaps = 90/493 (18%)

Query: 83   TVQRLADEGPVQSPSPHELQVLSP--LSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGE 140
            T+  +    P + P+P ++   S    +P +P P GAP    + P S +  P +      
Sbjct: 1466 TLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPAT------ 1519

Query: 141  TDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAP----TIPGP---PS 193
                   P+++  P  P     ++ TP    P E  +  +   P+P     IP P   P+
Sbjct: 1520 -------PSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPA 1572

Query: 194  QGDSRVSS------PSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLT 247
               S+ +S      PS   GA   P P E LL+P     P P   P    V  P  E   
Sbjct: 1573 TPSSKEASSPPAVTPSTYKGA---PSPKE-LLIPPAVTSPSPKEAPTPPAVTPPSPEKGP 1628

Query: 248  TTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKK 307
             T   K        +  +   S+K++ T   ++   + A     SKG+         AKK
Sbjct: 1629 ATPAPKGTPT----SPPVTPSSLKDSPTSPASVTCKMGATVPQASKGL--------PAKK 1676

Query: 308  YTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDME-LARAGS 366
                      G  A +E  V P  ES     A +     T +S   SP +  +  A+ GS
Sbjct: 1677 ----------GPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGS 1726

Query: 367  RASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQ 426
            +          G LS V+     L   Q+  + ++  + A   P      +G  +PP ++
Sbjct: 1727 K----------GPLSTVA--PAPLLPVQKDSSKTAKGKDASHSP------KGPLAPPESK 1768

Query: 427  SAPPEAAVLPPSPLPAP-----VASPRPFQPGGGAPTPAPSI-FNRSARPFTPGLQGQRP 480
            ++ P  A      LP P      A+P P      AP+P P++   +   P +PGL  + P
Sbjct: 1769 ASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESP 1828

Query: 481  TTTSVIFRPLAPKRANDSLGGLSPAP----PPFLSSQGPTPLPSFTSGVPSHAPVSGSPS 536
            +      +PLAP   ++ L  + P P     PF S     P P  ++G+P   P +  P 
Sbjct: 1829 S------KPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPK-SAGIPVPTPSAKQPV 1881

Query: 537  TPRSSGPVTATSS 549
            T  + G  T + S
Sbjct: 1882 TKNNKGSGTESDS 1894



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 164/695 (23%), Positives = 229/695 (32%), Gaps = 163/695 (23%)

Query: 88   ADEGPVQSPSPHELQVLSPL-SPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDAD 146
            A   P  +P+P      SP  SP +P P GAP P  + P S +  P   A    +     
Sbjct: 1302 ATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPT 1361

Query: 147  GPATQEKPRRPR----------------RRGPTRPTPPGAPPDEVYLSDSPAEPAPTIP- 189
             P+++E P  P                 +RGP  P+P G P     +  SP + AP  P 
Sbjct: 1362 TPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSP-KKAPATPV 1420

Query: 190  -----GPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAE 244
                   PS+GD             L PP    + L   P    P   P           
Sbjct: 1421 TREGAATPSKGD-------------LTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTL 1467

Query: 245  DLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAA--PNPHSKGVLMFKKRR 302
               T  + K   A  Q A S   K  K   T     A  L A    +P         +R 
Sbjct: 1468 PAVTPPSPKEPPAPKQVATSSSPK--KAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525

Query: 303  QRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELA 362
              A   TL+S    A T A +E  +PP               ++T  S   +P +     
Sbjct: 1526 PIAPTATLLSKKTPA-TLAPKEALIPP---------------AMTVPSPKKTPAIPTPKE 1569

Query: 363  RAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSP 422
               + +S+   S      S   G               S +EL  + PA         + 
Sbjct: 1570 APATPSSKEASSPPAVTPSTYKGA-------------PSPKELL-IPPAV--------TS 1607

Query: 423  PRAQSAPPEAAVLPPSP-----LPAPVASPR--PFQPGG--------------------- 454
            P  + AP   AV PPSP      PAP  +P   P  P                       
Sbjct: 1608 PSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQ 1667

Query: 455  ---GAP-------------TPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
               G P              PAP        P   G Q ++ + TS    P  P   N S
Sbjct: 1668 ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICP-DPSAKNGS 1726

Query: 499  LGGLSP-APPPFLSSQGPTPLPSFTSGVPSHAPVSG-SPSTPRSSGPVTAT--------- 547
             G LS  AP P L  Q  +   +      SH+P    +P   ++S P+TA          
Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKGKDA-SHSPKGPLAPPESKASTPLTAAAFEKVLPKP 1785

Query: 548  -SSLYIPAPSRPVTPGGAPE--PPAPPSAAAMTSTASIFLSAPLRPSARPE--------A 596
             S+    APS PV+   AP   P  PP    + S+  + L +P +P A  +         
Sbjct: 1786 ESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIP 1845

Query: 597  PAPGPGA----------PEPPSAREQRISVPAARTGILQEARRRGTRKQMFR--PGKEE- 643
            P P  G           P P SA    +  P+A+  + +  +  GT        P  EE 
Sbjct: 1846 PEPISGGVPFQSVLVNMPTPKSAGIP-VPTPSAKQPVTKNNKGSGTESDSDESVPELEEQ 1904

Query: 644  --TKNSPNPELLSLVQNLDEKPRAGGAESGPEEDA 676
              T+ +     L+    +DE+P +   +S  E+ A
Sbjct: 1905 DSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKA 1939



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 60/216 (27%), Positives = 79/216 (36%), Gaps = 36/216 (16%)

Query: 416 GEGLQSPPRAQSAPP----EAAVLPPSP---LPAPVASPRPFQPGGGAPTP--APSIFNR 466
           GE  ++ P  +   P    E AVLP S    + A +  P P  P   +P P   P     
Sbjct: 3   GEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAAN 62

Query: 467 SARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLG-----GLSPAPPPFLSSQGPTPLPSF 521
            A PF        P+ +++   PL       S G     G +P  P FL +    P+   
Sbjct: 63  QASPF--------PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPA 114

Query: 522 TSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEP--PAPPSAAAMTST 579
              + S         TP SS P+    +L   AP         P     +PPS A   S 
Sbjct: 115 ALALASPMIAPTLKGTPSSSAPL----ALVALAPHSVQKSSAFPPNLLTSPPSVAVAESG 170

Query: 580 ASIFLSAPLRPSAR-------PEAPAPGP-GAPEPP 607
           + I LSAP+ PS         P    P P G P PP
Sbjct: 171 SVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPP 206



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 44/160 (27%), Positives = 56/160 (35%), Gaps = 11/160 (6%)

Query: 88   ADEGPVQSPSPHELQVLSPLS-PLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDAD 146
            A   P  +P+P      SP   P +P P  AP P    P S +  P + +  G     A 
Sbjct: 932  ASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPA- 990

Query: 147  GPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWED 206
              AT   P+     GP  P+P GAP        SP       P P        ++P    
Sbjct: 991  --ATPPSPKG----GPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPK 1044

Query: 207  GA-ALQPPPAEALLLPHG--PLRPGPHLIPMVGPVPHPVA 243
            G+ A  P P  A   P    P   G    P +   P P A
Sbjct: 1045 GSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPA 1084



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 123/559 (22%), Positives = 184/559 (32%), Gaps = 88/559 (15%)

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIF 464
           L +V    + N +G  SPP   S  P   V P + + + VAS          P   P+  
Sbjct: 188 LNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVAS---------LPQTTPTTT 238

Query: 465 NRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSG 524
              A P     Q +  T +SV+  P  P     SL    P  PP   S     LP  TS 
Sbjct: 239 LAIASP-----QVKDTTISSVLISPQNP----GSLSLKGPVSPPAALSLSTQSLPVVTSS 289

Query: 525 VPSHAPVSGSPSTPRSSGPVTA---TSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTAS 581
             +  P +  P  P S G   A    SS           P    +P     +   +ST +
Sbjct: 290 QKTAGP-NTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGA 348

Query: 582 IFLS----APLRPSARPEAPAP-------GPGAPEPPSAREQRISVPAARTGILQEARRR 630
            + S     P  PS     PA         P   + PS        P+    +       
Sbjct: 349 SYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLS 408

Query: 631 GTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPV 690
            T   + +     T + P      LV  +                  S+G        P 
Sbjct: 409 PTTSLILKSSPNATYHYP------LVAQM---------------PVSSVGTTPLVVTNPC 447

Query: 691 G-ARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP-----PPVAPKPPSRGLLDGLVNGAAS 744
             A +  T   V     PPM+      + P +P      PVAPK PS  +   L      
Sbjct: 448 TIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTL--RIPV 505

Query: 745 SAGIPEPPRLQGRGGELFAKRQSRADRYVV----EGTP----GPGLGPRPRSPSPTPSLP 796
           S  +P+P  L+     +  K  ++ D   V    EG P      GL  + + P+  P + 
Sbjct: 506 SPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTK-KDPTVLPLVQ 564

Query: 797 PSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQ 856
            + K SP+ ++    + +P + P  P+A           P   P   + +   +      
Sbjct: 565 AAPKNSPSFQS---TSSSPEI-PLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASV 620

Query: 857 LKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEP--LAPTVLAPRAA-T 913
           +KT  +     P + GP+   S  T  V          P  +A+P  +APT     +  T
Sbjct: 621 IKTDSYA---GPDSAGPLLKSSLITPTVAAF-------PLESADPAGVAPTTAKGTSTYT 670

Query: 914 TLDEPIWRTELASAPVPSP 932
           T   P     ++ AP   P
Sbjct: 671 TTASPFLEGTVSLAPKNHP 689


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  102 bits (254), Expect = 2e-21
 Identities = 235/963 (24%), Positives = 328/963 (34%), Gaps = 189/963 (19%)

Query: 110 LSPEPPGAP-VPQPLQPGSLR-----------------------SPPDSEAYYGETDSDA 145
           L+P PPG+P  P P+ P +LR                       + P+S    G T S  
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSA- 83

Query: 146 DGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSW- 204
            G +++    RP   G     PP        +S        T PGP  Q   R+S+    
Sbjct: 84  -GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 142

Query: 205 EDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAES 264
             G A + P   AL         GP                  T  T     A+  RA  
Sbjct: 143 ARGKATEAPKRSALSAGARRDTSGP------------------TPGTPSPAMARRSRAAG 184

Query: 265 LQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEE 324
            +    + A +          A P P ++G    +K    A +++      AA       
Sbjct: 185 TEVGLPRPAPS----------ARPRPPTEGP---RKSVSSASEHSTTEPSPAARRRPSAG 231

Query: 325 DGVPPTSESELDEEAF---SDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLS 381
            G+   +   L   A    S ARS    S   +P       RA +  S+ +  GL     
Sbjct: 232 GGLQRPASRSLSSSATPLSSPARS--GPSARGTP-------RAPAHPSQPKPKGLQAL-- 280

Query: 382 EVSGRGVQLFEQQRQRADS----STQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPP 437
               R  Q+   ++  A +    S+  LA   P+     +    PP   +A P  A LPP
Sbjct: 281 ----RPPQVTPPRKDAAPALGPLSSSPLATPSPSGT---KARPVPPPDNAATPLPATLPP 333

Query: 438 SPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP-----LAP 492
           SP   P+A+P P  P   +P+  PS+    + P TP  Q     TT  +  P     + P
Sbjct: 334 SP---PLATPLPLAPP--SPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPP 388

Query: 493 KRANDSLGGLS----PAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSP------------- 535
            +   SL   S    P+P    S Q  T L S T    +H+ ++ SP             
Sbjct: 389 IQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQA-THSFLTMSPRQTQASLTSPSRP 447

Query: 536 -STPRSSGPVTATSSLYIPAP-----SRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLR 589
            STP  S P+ A  SL    P     S  V+P  +P    P    A++S AS    APL 
Sbjct: 448 ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP--LQALSSLASHSPQAPLS 505

Query: 590 ----PSARPEAPAPGPGAPEPPSA--REQRISVPAARTGILQEARRRGTRKQMFRP---- 639
               P    ++    P    PP++       ++P+     LQ A    T   +  P    
Sbjct: 506 SLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPA 565

Query: 640 -----GKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARS 694
                       +P PE  S +      P+A  A + P    L     +     P  A  
Sbjct: 566 PCPLQAPPSPLTTPPPETPSSIAT--PPPQAPPALASPPLQGLPSPPLSPLATPPPQAPP 623

Query: 695 YKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRL 754
              LP   P   PP  P +PP     TP P AP   +  LL       A  +  P PP +
Sbjct: 624 XLALP---PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ------APFSPPPSPP-V 673

Query: 755 QGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYN 814
           Q       +   S +     +  P     P    PSP  S P S   +P  +APPP+A  
Sbjct: 674 QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 733

Query: 815 PLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPI 874
           PL  P  P A+  +  + +  PR  P      L      P  L  +       PP   P 
Sbjct: 734 PLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLA---KPPPQAPP 790

Query: 875 ASGSPKTARVQE------------------IRRFSTPAPQ------------PTAEPLAP 904
           A  +P    +                    +   +TP PQ            P + P +P
Sbjct: 791 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 850

Query: 905 TVLAPRAATT--LDEPIWRTELASAPVPSPAPPPEAPRGLGASPSS--CGFQVARPRFSA 960
           T+ APR   T   D  +    L  A  P P PPP        SPSS   G  +A    SA
Sbjct: 851 TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP------SRSPSSTLSGPDLAGHSSSA 904

Query: 961 TRT 963
           T T
Sbjct: 905 TST 907



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 211/834 (25%), Positives = 278/834 (33%), Gaps = 119/834 (14%)

Query: 90  EGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDA---D 146
           EGP +S S       S     + EP  A   +P   G L+ P         T   +    
Sbjct: 203 EGPRKSVS-------SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255

Query: 147 GPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWED 206
           GP+ +  PR P    P++P P G           P + A    GP S       SPS   
Sbjct: 256 GPSARGTPRAPAH--PSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTK 313

Query: 207 GAALQPPPAEALLLPHGPLRPGPHL-IPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESL 265
              + PP   A  LP   L P P L  P+    P P A     T          Q   S+
Sbjct: 314 ARPVPPPDNAATPLP-ATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSM 372

Query: 266 QEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEED 325
               + +A    +TI  +      PHS   L     +       L S  A    G+    
Sbjct: 373 TTPPM-QAPPSLQTIPPIQV----PHS---LTSPSLQAPPSPLALSSLQATTSLGSPTLQ 424

Query: 326 GVPP-TSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGS----RASEGQGSGLGGQL 380
                 + S    +A   + S    +  DSP L   L+   S     +     S L   L
Sbjct: 425 ATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPL 484

Query: 381 SEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPP--EAAVLPPS 438
           +    + +        +A  S+  +  +E  + L    LQ+PP + + PP      L P 
Sbjct: 485 TIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPP 544

Query: 439 PL---PAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP---LAP 492
           PL    AP+ +P    P    P PAP        P T       P T S I  P     P
Sbjct: 545 PLQTASAPLTTPHLETP----PCPAPCPLQAPPSPLTT----PPPETPSSIATPPPQAPP 596

Query: 493 KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVS-------------------- 532
             A+  L GL P+PP    +  P   P   +  P  AP S                    
Sbjct: 597 ALASPPLQGL-PSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNA 655

Query: 533 ------GSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAA--MTSTASIFL 584
                  +P +P  S PV A  S   P  S PV+P   P   APPS AA  +    S   
Sbjct: 656 LAVHLLQAPFSPPPSPPVQAPFS---PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 712

Query: 585 SAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEET 644
           S P+ PSA P   AP P A  P          P A   +   A        +      + 
Sbjct: 713 SPPMSPSATPPPQAPPPLAAPPLQVPPS----PPASPPMSPSATPPPRVPPLLAAPPLQV 768

Query: 645 KNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPK 704
             SP P  L +       P+A  A + P   AL   +   +F          +LP     
Sbjct: 769 PPSP-PASLPMSPLAKPPPQAPPALATPPLQALP--SPPASFPGQAPFSPSASLPMSPLA 825

Query: 705 TPPPMAPKT-------PPPMTPKTPPPVAPKPPSRGLLDGLVNG----AASSAGIPEPPR 753
           TPPP AP          PP  P +P   AP+ P     D  V+G     A + G P PP 
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 885

Query: 754 LQGR---GGELFAKRQSRADRYVVE--GTPGPGLGPRPRSPSPTPSL----PPSWKYSPN 804
                   G   A   S A     E  G      G    SP P   L    P +W   P 
Sbjct: 886 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP- 944

Query: 805 IRAPP---------PIAYNPLLSPFFPQAARTLPKAQSQGPR-ATPKQGIKALD 848
             APP         P+ + P   P       T+   +++GP  ATP  G  ALD
Sbjct: 945 --APPLAFRGAPGAPLPWPPATGPGSADGLCTI--YETEGPESATPAPG--ALD 992



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/801 (22%), Positives = 250/801 (31%), Gaps = 137/801 (17%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P  LQ L P     P    AP   PL    L +P  S               T+ +P 
Sbjct: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS--------------GTKARPV 317

Query: 156 RPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
            P     T P P   PP     S   A P P  P  PS   S  + PS       Q PP+
Sbjct: 318 PPPDNAAT-PLPATLPP-----SPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPS 371

Query: 216 EALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKT 275
             +  P     P    IP +  VPH +              + LQ   SL   +++    
Sbjct: 372 --MTTPPMQAPPSLQTIPPI-QVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATH- 427

Query: 276 KCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESEL 335
                 S LT +P                  + T  S  + +   +   D  P  +   L
Sbjct: 428 ------SFLTMSP------------------RQTQASLTSPSRPASTPPDSPPLQAPLSL 463

Query: 336 DEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQR 395
                         S   SP     L    S AS    + L   +         L     
Sbjct: 464 PASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSL 523

Query: 396 QRADSST-----QELARVEP------AAMLNGEGLQSPPRAQ----SAPPEAAVLPPSPL 440
           Q   +S      + L  + P      +A L    L++PP        APP     PP   
Sbjct: 524 QTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPET 583

Query: 441 PAPVASPRPFQPGGGAPTPAPSIFNRSARPFT------------PGLQGQRPTTTSVIFR 488
           P+ +A+P P  P   A  P   + +    P              P LQ       S    
Sbjct: 584 PSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLS 643

Query: 489 PLA---PKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVT 545
           PLA   P+  N     L  AP     S  P+P        P+  PVS S + P  + P  
Sbjct: 644 PLATPSPQAPNALAVHLLQAP----FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 699

Query: 546 ATSSLYIPAP---SRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPG 602
           A   L +P     S P++P   P P APP  AA           P  P++ P +P+  P 
Sbjct: 700 AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP-----PSPPASPPMSPSATPP 754

Query: 603 APEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEK 662
              PP      + VP +    L  +        + +P  +       P L +L       
Sbjct: 755 PRVPPLLAAPPLQVPPSPPASLPMS-------PLAKPPPQAPPALATPPLQAL-----PS 802

Query: 663 PRAGGAESGPEEDALSLG----AEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMT 718
           P A      P   + SL     A       PV A     +P   P +P   AP+ PP   
Sbjct: 803 PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG 862

Query: 719 PKT---------------PPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFA 763
           P T               PPP +  P S      L   ++S+   PE  R    G E  A
Sbjct: 863 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922

Query: 764 KRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNP-------- 815
                 D  +    P        R P+P    P +++ +P    P P A  P        
Sbjct: 923 AASPPPDAELAACHPAAW----SRGPAP----PLAFRGAPGAPLPWPPATGPGSADGLCT 974

Query: 816 LLSPFFPQAARTLPKAQSQGP 836
           +     P++A   P A   GP
Sbjct: 975 IYETEGPESATPAPGALDPGP 995



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 132/542 (24%), Positives = 189/542 (34%), Gaps = 97/542 (17%)

Query: 424 RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTT 483
           +   A   AA   P+     + +PRP     G+P P P        P TP          
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTPRP----PGSPRPPP--------PVTPAALRVLGAAG 51

Query: 484 SVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRS--S 541
           +V  +PLA +      GG+  A  P      P   P+ ++G  S  P S  P++ R   +
Sbjct: 52  AVGRKPLAERA-----GGIGGATIP---ESAPRAGPTRSAGTSSRNPASRPPASGRGERA 103

Query: 542 GPVTATSSLYIPAPSRP---VTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPS----ARP 594
            P   TS   + +P R      PG   +     SA    +       AP R +    AR 
Sbjct: 104 PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA-TEAPKRSALSAGARR 162

Query: 595 EAPAPGPGAPEPPSAREQR-----ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPN 649
           +   P PG P P  AR  R     + +P             G RK +     E +   P+
Sbjct: 163 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV-SSASEHSTTEPS 221

Query: 650 PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
           P           +P AGG    P   +LS  A   +     G  +       TP+ P   
Sbjct: 222 PA-------ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA-----RGTPRAPAHP 269

Query: 710 APKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRA 769
           +   P  +    PP V   PP +     L   ++S    P P                  
Sbjct: 270 SQPKPKGLQALRPPQVT--PPRKDAAPALGPLSSSPLATPSP------------------ 309

Query: 770 DRYVVEGTPGPGLGPRPRSPSPTP-SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTL 828
                 GT    + P   + +P P +LPP    SP +  P P+A     SP  P + +TL
Sbjct: 310 -----SGTKARPVPPPDNAATPLPATLPP----SPPLATPLPLAPP---SPSAPPSLQTL 357

Query: 829 PKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIR 888
           P      P ATP    +A   M   P Q   ++     +PP   P +  SP         
Sbjct: 358 P-----SPPATPPS--QAPPSMTTPPMQAPPSL---QTIPPIQVPHSLTSPSLQAPPSPL 407

Query: 889 RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELAS----APVPSPAPPPEAPRGLGA 944
             S  + Q T    +PT+ A  +  T+     +  L S    A  P  +PP +AP  L A
Sbjct: 408 ALS--SLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPA 465

Query: 945 SP 946
           SP
Sbjct: 466 SP 467



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 113/443 (25%), Positives = 160/443 (36%), Gaps = 89/443 (20%)

Query: 541 SGPVTATSSLYIPAPSRPVTPGGA-PEPPAPPSAAAMTSTASIFLSAPLRPSAR------ 593
           +G    T +   P    P  PG   P PP  P+A  +   A      PL   A       
Sbjct: 10  AGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT 69

Query: 594 -PE-APAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNP- 650
            PE AP  GP      S+R      PA+  G      +  +   +  PG+      P P 
Sbjct: 70  IPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 651 ELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPP-M 709
               L  + +E    G A   P+  ALS GA              +     TP TP P M
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGAR-------------RDTSGPTPGTPSPAM 176

Query: 710 APKTPPPMT----PKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKR 765
           A ++    T    P+  P   P+PP+ G    + + +  S   P P           A+R
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA----------ARR 226

Query: 766 QSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAA 825
           +  A         G GL  RP S S + S  P    S   R+ P              +A
Sbjct: 227 RPSA---------GGGL-QRPASRSLSSSATP---LSSPARSGP--------------SA 259

Query: 826 RTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQ 885
           R  P+A +   +  PK G++AL     +P Q+        +  P  GP++S SP      
Sbjct: 260 RGTPRAPAHPSQPKPK-GLQAL-----RPPQVTPPR---KDAAPALGPLSS-SP------ 303

Query: 886 EIRRFSTPAPQPT-AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGA 944
                +TP+P  T A P+ P      AAT L   +  +   + P+P   P P AP  L  
Sbjct: 304 ----LATPSPSGTKARPVPPP---DNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQT 356

Query: 945 SPSSCGFQVARPRFSATRTGLQA 967
            PS      ++   S T   +QA
Sbjct: 357 LPSPPATPPSQAPPSMTTPPMQA 379



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 111/461 (24%), Positives = 144/461 (31%), Gaps = 94/461 (20%)

Query: 92   PVQSP-SPHELQVLSPLSPLSPEPPGAPVPQPLQ-PGSLRSPPDSEAYYGETDSDADGP- 148
            P+Q+P SP     LSPL+  SP+ P A     LQ P S    P  +A +    S    P 
Sbjct: 629  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 688

Query: 149  ATQEKPRRPRRRGP---TRPTPPGAPPDEVYLSDSPAEP----APTIPGPPSQGDSRVSS 201
            AT      P    P     P+PP +PP     +  P  P    AP +  PPS   S   S
Sbjct: 689  ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMS 748

Query: 202  PSWED---------GAALQPPPAEALLLPHGPL-RPGPHLIPMVGPVPHPVAEDLTTTYT 251
            PS               LQ PP+    LP  PL +P P   P +     P  + L +   
Sbjct: 749  PSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALAT---PPLQALPSPPA 805

Query: 252  QKAKQAKLQRAESLQEKSIKEAKTKCRTI--ASLLTAAPNPHSKGVLMFKKRRQRAKKYT 309
                QA    + SL    +     +   +  A LL   P+P +   L   +R       T
Sbjct: 806  SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 865

Query: 310  LVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRAS 369
             VS      T A      PP S S                                  +S
Sbjct: 866  SVS--GPRLTLALAPGPPPPPSRSP---------------------------------SS 890

Query: 370  EGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAP 429
               G  L G  S                  +ST E  R   +    G     PP A+ A 
Sbjct: 891  TLSGPDLAGHSSSA----------------TSTPEELRGYDSGPEGGAAASPPPDAELAA 934

Query: 430  PEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP 489
               A     P P     P  F+   GAP P P           P            I+  
Sbjct: 935  CHPAAWSRGPAP-----PLAFRGAPGAPLPWP-----------PATGPGSADGLCTIYET 978

Query: 490  LAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAP 530
              P+ A  + G L P P P   + G        +G  S +P
Sbjct: 979  EGPESATPAPGALDPGPSP--GTSGGKAAAGAGAGASSRSP 1017



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 50/180 (27%), Positives = 65/180 (36%), Gaps = 42/180 (23%)

Query: 87  LADEGPVQSPSPH---ELQVLS--PLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGET 141
           LA   P+  PSP     LQ L   P +P S  PP    P    P SL++ P  +  +  T
Sbjct: 337 LATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLT 396

Query: 142 DSDADGP---------------------ATQE----KPRRPRRR--GPTRP--TPPGAPP 172
                 P                     AT       PR+ +     P+RP  TPP +PP
Sbjct: 397 SPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPP 456

Query: 173 DEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLI 232
            +  LS   + P  T   P     S +SSP       + P  A + L  H P  P   LI
Sbjct: 457 LQAPLSLPASPPLQTSLSP---AVSPLSSP-----LTIHPLQALSSLASHSPQAPLSSLI 508


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/575 (24%), Positives = 201/575 (34%), Gaps = 115/575 (20%)

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQE-LARVEPAA--MLNGEGLQSPPRAQSAPPE--A 432
           G+    S +  Q  E+   +  + T + LA+  P A     G  L +P       P+  A
Sbjct: 166 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 225

Query: 433 AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
           +  P  P P  + S  P  P   APT   S       P TP  +   PTTT     P  P
Sbjct: 226 STTPKEPTPTTIKSA-PTTPKEPAPTTTKSA------PTTP--KEPAPTTTKEP-APTTP 275

Query: 493 KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           K          PAP     +    P P+ T   P+  P   +P+TP+   P T       
Sbjct: 276 KE---------PAP-----TTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKE---- 316

Query: 553 PAPSRPVTPGGA-PEPPAPPSAA-AMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPS 608
           PAP+ P  P    P+ PAP +   A T+      +AP +P+   P+ PAP  P  P P +
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376

Query: 609 AREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGA 668
            +E   + P                     P    TK++P            ++P     
Sbjct: 377 TKEPSPTTPK-------------------EPAPTTTKSAPTTT---------KEPAPTTT 408

Query: 669 ESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 728
           +S P               +P    + +  P  TPK P P  PK P P TPK P P  PK
Sbjct: 409 KSAPTTPK-----------EPSPTTTKEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPK 456

Query: 729 PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS 788
            P           A ++   P P   +        +      + +   TP       P  
Sbjct: 457 EP-----------APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK 505

Query: 789 PSPTP--SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKA 846
           P+PT    L P+    P    P   A      P  P+AA   P    +    TPK+    
Sbjct: 506 PAPTTPEELAPTTPEEPTPTTPEEPA------PTTPKAAA--PNTPKEPAPTTPKEPA-- 555

Query: 847 LDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ-PTAEPLAPT 905
                  P   K      +  P TP   A  +PK      ++  +   P+ P  + LAPT
Sbjct: 556 -------PTTPK------EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 602

Query: 906 VLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPR 940
                 +TT D+P   T   +AP     P P  P+
Sbjct: 603 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 637



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 144/558 (25%), Positives = 200/558 (35%), Gaps = 77/558 (13%)

Query: 395 RQRADSSTQELARV---EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQ 451
           ++ A ++T+E A     EPA     E   +P   +SAP      P  P P     P P  
Sbjct: 260 KEPAPTTTKEPAPTTPKEPAPTTTKE--PAPTTTKSAP----TTPKEPAPTTPKKPAPTT 313

Query: 452 PGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
           P   APT        + +   P  +   PTT      P APK+   +    +P  P   +
Sbjct: 314 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTAPKKPAPT----TPKEPAPTT 368

Query: 512 SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            + P P    T+  PS       P+TP+   P T  S+        P T   AP  P  P
Sbjct: 369 PKEPAPT---TTKEPS-------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 418

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           S    T+T     + P  P+   P+ PAP  P  P P + +E   +          +   
Sbjct: 419 SP---TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 475

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM-- 687
             T K+   P   +      PE   L     EKP    A + PEE A +   E       
Sbjct: 476 PTTPKET-APTTPKKLTPTTPE--KLAPTTPEKP----APTTPEELAPTTPEEPTPTTPE 528

Query: 688 QPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG 747
           +P         P+ TPK P P  PK P P TPK P P  PK  +     G    A ++  
Sbjct: 529 EPAPTTPKAAAPN-TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT---APTTLK 584

Query: 748 IPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP----GLGP-RPRSPSPTPSLPPSWKYS 802
            P P   +    +  A   ++         P P    G  P  P+ P+PT    P+   +
Sbjct: 585 EPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA-PTT 643

Query: 803 PNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMF 862
           P   AP  +      +P  P A + L    ++GP +T           +  P   K    
Sbjct: 644 PKGTAPTTLKEPAPTTPKKP-APKELAPTTTKGPTSTTSD--------KPAPTTPK---- 690

Query: 863 CFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEP--IW 920
             +  P TP   A  +PK            PAP  T E   PT       TT  EP  I 
Sbjct: 691 --ETAPTTPKEPAPTTPK-----------KPAP-TTPETPPPTTSEVSTPTTTKEPTTIH 736

Query: 921 RTELASAPVPSPAPPPEA 938
           ++   S P  S  P P+A
Sbjct: 737 KSPDESTPELSAEPTPKA 754



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 179/842 (21%), Positives = 267/842 (31%), Gaps = 137/842 (16%)

Query: 150 TQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAA 209
           T  K   P  +   +PTP      +     +P EP PT P  P+    +  +P+    A 
Sbjct: 182 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 241

Query: 210 L---QPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKA----KQAKLQRA 262
               +P P      P  P  P P       P P    E   TT  + A    K A     
Sbjct: 242 TTPKEPAPTTTKSAPTTPKEPAP--TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 299

Query: 263 ESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAE 322
           E       K A T  +  A      P P +      K+     K+    +    A T  +
Sbjct: 300 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-----KEPAPTTKEPAPTTPKEPAPTAPK 354

Query: 323 EEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE 382
           +    P T +          A + T +    SP    E A   +++              
Sbjct: 355 KP--APTTPKEPAPTTPKEPAPTTTKE---PSPTTPKEPAPTTTKS-------------- 395

Query: 383 VSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA 442
                          A ++T+E A   P    +       P   +    A   P  P P 
Sbjct: 396 ---------------APTTTKEPA---PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 437

Query: 443 PVASPRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
               P P  P   APT    PAP+   + A P TP  +   PTT      P  PK+    
Sbjct: 438 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTP--KEPAPTTPKET-APTTPKK---- 489

Query: 499 LGGLSPAPPPFLSSQGP-TPLPSFTSGVPSHAPVSGSPSTPRSSGPVT----ATSSLYIP 553
              L+P  P  L+   P  P P+    +    P   +P+TP    P T    A ++   P
Sbjct: 490 ---LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 546

Query: 554 APSRPVTPG-GAPEPPAP--PSAAAMTS---TASIFLSAPLRPSARPEAPAP---GPGAP 604
           AP+ P  P    P+ PAP  P   A T+   TA   L  P      P+ PAP    P   
Sbjct: 547 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP--APTTPKKPAPKELAPTTT 604

Query: 605 EPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR 664
           + P++       P    G      +         P     K +    L        +KP 
Sbjct: 605 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP- 663

Query: 665 AGGAESGPEEDA--LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP 722
                  P+E A   + G  +    +P      +T P  TPK P P  PK P P TP+TP
Sbjct: 664 ------APKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPAPTTPKKPAPTTPETP 716

Query: 723 PPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGL 782
           PP   +              ++     EP  +     E   +  +      +E +P    
Sbjct: 717 PPTTSE-------------VSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 763

Query: 783 GPRPRSPSPT-PSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPK 841
            P  ++P+ T P +  + K     R           +P   +   T  +  ++       
Sbjct: 764 VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 823

Query: 842 QGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEP 901
             + +       P+++ T          T  P  + + KT    EI       P+ TA+P
Sbjct: 824 TQVTSTTTQDTTPFKITTLK------TTTLAPKVTTTKKTITTTEIMN----KPEETAKP 873

Query: 902 LAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSAT 961
                              R   + A  P P  P +AP+     P+S       PR    
Sbjct: 874 KD-----------------RATNSKATTPKPQKPTKAPK----KPTSTKKPKTMPRVRKP 912

Query: 962 RT 963
           +T
Sbjct: 913 KT 914



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 129/564 (22%), Positives = 185/564 (32%), Gaps = 90/564 (15%)

Query: 94  QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQE- 152
           + P+P   +  +P +P  P P     P P  P   + P                P T+E 
Sbjct: 299 KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP---KEP---------------APTTKEP 340

Query: 153 KPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA---A 209
            P  P+   PT P  P     +     +P EPAPT    PS    +  +P+    A    
Sbjct: 341 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 400

Query: 210 LQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKS 269
            +P P      P  P  P P       P P    E   TT  + A     + A +  +  
Sbjct: 401 KEPAPTTTKSAPTTPKEPSP--TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-- 456

Query: 270 IKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPP 329
            + A T  +  A      P P +      +      KK T  +    A T  E+     P
Sbjct: 457 -EPAPTTTKKPAPTTPKEPAPTTPK----ETAPTTPKKLTPTTPEKLAPTTPEKP---AP 508

Query: 330 TSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQ 389
           T+  EL      +    T     + P      A A +   E   +               
Sbjct: 509 TTPEELAPTTPEEPTPTTP----EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------ 558

Query: 390 LFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS--- 446
                ++ A ++ +E A   P        L+ P       P    L P+    P ++   
Sbjct: 559 ----PKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD 613

Query: 447 -PRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            P P  P G APT    PAP+     A P TP  +G  PTT      P  PK+       
Sbjct: 614 KPAPTTPKGTAPTTPKEPAPTTPKEPA-PTTP--KGTAPTTLKEP-APTTPKK------- 662

Query: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTP 561
             PAP            P+ T G  S      +P+TP+ + P T       PAP+ P  P
Sbjct: 663 --PAPKEL--------APTTTKGPTSTTSDKPAPTTPKETAPTTPKE----PAPTTPKKP 708

Query: 562 G-GAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAAR 620
               PE P P ++   T T +     P      P+   P   A   P A E     P   
Sbjct: 709 APTTPETPPPTTSEVSTPTTT---KEPTTIHKSPDESTPELSAEPTPKALENSPKEP--- 762

Query: 621 TGILQEARRRGTRKQMFRPGKEET 644
            G+        T+ +M    K++T
Sbjct: 763 -GVPTTKTPAATKPEMTTTAKDKT 785



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 113/501 (22%), Positives = 159/501 (31%), Gaps = 95/501 (18%)

Query: 457 PTPAPSIFNRSARPFTPG-LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP--PPFLSSQ 513
           PTP P + + +      G  +   P T++     ++      +   ++P P  PP   + 
Sbjct: 78  PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 137

Query: 514 GPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP--APP 571
             T L             + +     + G    TS+    +  +      AP     A P
Sbjct: 138 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 197

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           +  A T+T    L+ P  P+   P+ PA   P  P P + +    S P            
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK----SAPT----------- 242

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQP 689
             T K+   P    TK++P            E      A + P+E A +   E      P
Sbjct: 243 --TPKE---PAPTTTKSAPTTPKEPAPTTTKEP-----APTTPKEPAPTTTKEPA----P 288

Query: 690 VGARSYKTLPH----VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASS 745
              +S  T P      TPK P P  PK P P TPK P P  PK P+            + 
Sbjct: 289 TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA----------PTTK 338

Query: 746 AGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNI 805
              P  P+          +    A +     TP       P+ P+PT +  PS   +P  
Sbjct: 339 EPAPTTPK----------EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKE 387

Query: 806 RAPPPIAYNPLLS----PFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAM 861
            AP      P  +    P   ++A T PK  S      P                     
Sbjct: 388 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP------------------- 428

Query: 862 FCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWR 921
                 P  P P     P     +E      PAP    EP APT     A TT  EP   
Sbjct: 429 ----TTPKEPAPTTPKKPAPTTPKE------PAPTTPKEP-APTTTKKPAPTTPKEPAPT 477

Query: 922 TELASAPVPSPAPPPEAPRGL 942
           T   +AP       P  P  L
Sbjct: 478 TPKETAPTTPKKLTPTTPEKL 498



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 84/210 (40%), Gaps = 42/210 (20%)

Query: 94  QSPSPHELQVLSPLSPLSPEP--PGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
           + P+P   +  +P +   P P  P  P P+ L P + + P         T + +D PA  
Sbjct: 637 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP---------TSTTSDKPA-- 685

Query: 152 EKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSP-SWEDGAAL 210
             P  P+   PT P  P AP        +P +PAPT P  P    S VS+P + ++   +
Sbjct: 686 --PTTPKETAPTTPKEP-AP-------TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTI 735

Query: 211 QPPPAEAL----------LLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
              P E+            L + P  PG   +P     P     ++TTT   K  +  L+
Sbjct: 736 HKSPDESTPELSAEPTPKALENSPKEPG---VPTT-KTPAATKPEMTTTAKDKTTERDLR 791

Query: 261 ---RAESLQEKSIKE-AKTKCRTIASLLTA 286
                 +   K  KE A T  +T  S +TA
Sbjct: 792 TTPETTTAAPKMTKETATTTEKTTESKITA 821



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 26/193 (13%)

Query: 105 SPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR 164
           +P +P  P P     P P  P   + P  +      T  +     T+  P  P+   PT 
Sbjct: 255 APTTPKEPAPTTTKEPAPTTP---KEPAPT------TTKEPAPTTTKSAPTTPKEPAPTT 305

Query: 165 PTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP----PPAEALLL 220
           P  P AP        +P EPAPT P  P+    +  +P+ ++ A   P    P A     
Sbjct: 306 PKKP-APT-------TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 357

Query: 221 PHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQE---KSIKEAKTKC 277
           P  P  P P       P P    E   TT  + A         + +E    + K A T  
Sbjct: 358 PTTPKEPAP--TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 415

Query: 278 RTIASLLTAAPNP 290
           +  +   T  P P
Sbjct: 416 KEPSPTTTKEPAP 428



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 41/172 (23%), Positives = 60/172 (34%), Gaps = 11/172 (6%)

Query: 83  TVQRLADEGPVQSPSPHELQVLSPLSP-----LSPEPPGAPVPQPLQPGSLRSPPDSEAY 137
           T ++LA   P + P+P   + L+P +P      +PE P    P+   P + + P  +   
Sbjct: 494 TPEKLAPTTP-EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 552

Query: 138 YGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDS 197
                +  +   T  K   P     T PT    P        +P E APT    P+    
Sbjct: 553 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 612

Query: 198 RVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTT 249
              +P+   G A   P   A   P  P    P      G  P  + E   TT
Sbjct: 613 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK-----GTAPTTLKEPAPTT 659


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/575 (24%), Positives = 201/575 (34%), Gaps = 115/575 (20%)

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQE-LARVEPAA--MLNGEGLQSPPRAQSAPPE--A 432
           G+    S +  Q  E+   +  + T + LA+  P A     G  L +P       P+  A
Sbjct: 207 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 266

Query: 433 AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
           +  P  P P  + S  P  P   APT   S       P TP  +   PTTT     P  P
Sbjct: 267 STTPKEPTPTTIKSA-PTTPKEPAPTTTKSA------PTTP--KEPAPTTTKEP-APTTP 316

Query: 493 KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           K          PAP     +    P P+ T   P+  P   +P+TP+   P T       
Sbjct: 317 KE---------PAP-----TTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKE---- 357

Query: 553 PAPSRPVTPGGA-PEPPAPPSAA-AMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPS 608
           PAP+ P  P    P+ PAP +   A T+      +AP +P+   P+ PAP  P  P P +
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417

Query: 609 AREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGA 668
            +E   + P                     P    TK++P            ++P     
Sbjct: 418 TKEPSPTTPK-------------------EPAPTTTKSAPTTT---------KEPAPTTT 449

Query: 669 ESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 728
           +S P               +P    + +  P  TPK P P  PK P P TPK P P  PK
Sbjct: 450 KSAPTTPK-----------EPSPTTTKEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPK 497

Query: 729 PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS 788
            P           A ++   P P   +        +      + +   TP       P  
Sbjct: 498 EP-----------APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK 546

Query: 789 PSPTP--SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKA 846
           P+PT    L P+    P    P   A      P  P+AA   P    +    TPK+    
Sbjct: 547 PAPTTPEELAPTTPEEPTPTTPEEPA------PTTPKAAA--PNTPKEPAPTTPKEPA-- 596

Query: 847 LDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ-PTAEPLAPT 905
                  P   K      +  P TP   A  +PK      ++  +   P+ P  + LAPT
Sbjct: 597 -------PTTPK------EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 643

Query: 906 VLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPR 940
                 +TT D+P   T   +AP     P P  P+
Sbjct: 644 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 678



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 144/558 (25%), Positives = 200/558 (35%), Gaps = 77/558 (13%)

Query: 395 RQRADSSTQELARV---EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQ 451
           ++ A ++T+E A     EPA     E   +P   +SAP      P  P P     P P  
Sbjct: 301 KEPAPTTTKEPAPTTPKEPAPTTTKE--PAPTTTKSAP----TTPKEPAPTTPKKPAPTT 354

Query: 452 PGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
           P   APT        + +   P  +   PTT      P APK+   +    +P  P   +
Sbjct: 355 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTAPKKPAPT----TPKEPAPTT 409

Query: 512 SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            + P P    T+  PS       P+TP+   P T  S+        P T   AP  P  P
Sbjct: 410 PKEPAPT---TTKEPS-------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 459

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           S    T+T     + P  P+   P+ PAP  P  P P + +E   +          +   
Sbjct: 460 SP---TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 516

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM-- 687
             T K+   P   +      PE   L     EKP    A + PEE A +   E       
Sbjct: 517 PTTPKET-APTTPKKLTPTTPE--KLAPTTPEKP----APTTPEELAPTTPEEPTPTTPE 569

Query: 688 QPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG 747
           +P         P+ TPK P P  PK P P TPK P P  PK  +     G    A ++  
Sbjct: 570 EPAPTTPKAAAPN-TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT---APTTLK 625

Query: 748 IPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP----GLGP-RPRSPSPTPSLPPSWKYS 802
            P P   +    +  A   ++         P P    G  P  P+ P+PT    P+   +
Sbjct: 626 EPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA-PTT 684

Query: 803 PNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMF 862
           P   AP  +      +P  P A + L    ++GP +T           +  P   K    
Sbjct: 685 PKGTAPTTLKEPAPTTPKKP-APKELAPTTTKGPTSTTSD--------KPAPTTPK---- 731

Query: 863 CFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEP--IW 920
             +  P TP   A  +PK            PAP  T E   PT       TT  EP  I 
Sbjct: 732 --ETAPTTPKEPAPTTPK-----------KPAP-TTPETPPPTTSEVSTPTTTKEPTTIH 777

Query: 921 RTELASAPVPSPAPPPEA 938
           ++   S P  S  P P+A
Sbjct: 778 KSPDESTPELSAEPTPKA 795



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 179/842 (21%), Positives = 267/842 (31%), Gaps = 137/842 (16%)

Query: 150 TQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAA 209
           T  K   P  +   +PTP      +     +P EP PT P  P+    +  +P+    A 
Sbjct: 223 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 282

Query: 210 L---QPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKA----KQAKLQRA 262
               +P P      P  P  P P       P P    E   TT  + A    K A     
Sbjct: 283 TTPKEPAPTTTKSAPTTPKEPAP--TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 340

Query: 263 ESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAE 322
           E       K A T  +  A      P P +      K+     K+    +    A T  +
Sbjct: 341 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-----KEPAPTTKEPAPTTPKEPAPTAPK 395

Query: 323 EEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE 382
           +    P T +          A + T +    SP    E A   +++              
Sbjct: 396 KP--APTTPKEPAPTTPKEPAPTTTKE---PSPTTPKEPAPTTTKS-------------- 436

Query: 383 VSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA 442
                          A ++T+E A   P    +       P   +    A   P  P P 
Sbjct: 437 ---------------APTTTKEPA---PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 478

Query: 443 PVASPRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
               P P  P   APT    PAP+   + A P TP  +   PTT      P  PK+    
Sbjct: 479 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTP--KEPAPTTPKET-APTTPKK---- 530

Query: 499 LGGLSPAPPPFLSSQGP-TPLPSFTSGVPSHAPVSGSPSTPRSSGPVT----ATSSLYIP 553
              L+P  P  L+   P  P P+    +    P   +P+TP    P T    A ++   P
Sbjct: 531 ---LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 587

Query: 554 APSRPVTPG-GAPEPPAP--PSAAAMTS---TASIFLSAPLRPSARPEAPAP---GPGAP 604
           AP+ P  P    P+ PAP  P   A T+   TA   L  P      P+ PAP    P   
Sbjct: 588 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP--APTTPKKPAPKELAPTTT 645

Query: 605 EPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR 664
           + P++       P    G      +         P     K +    L        +KP 
Sbjct: 646 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP- 704

Query: 665 AGGAESGPEEDA--LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP 722
                  P+E A   + G  +    +P      +T P  TPK P P  PK P P TP+TP
Sbjct: 705 ------APKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPAPTTPKKPAPTTPETP 757

Query: 723 PPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGL 782
           PP   +              ++     EP  +     E   +  +      +E +P    
Sbjct: 758 PPTTSE-------------VSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 804

Query: 783 GPRPRSPSPT-PSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPK 841
            P  ++P+ T P +  + K     R           +P   +   T  +  ++       
Sbjct: 805 VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 864

Query: 842 QGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEP 901
             + +       P+++ T          T  P  + + KT    EI       P+ TA+P
Sbjct: 865 TQVTSTTTQDTTPFKITTLK------TTTLAPKVTTTKKTITTTEIMN----KPEETAKP 914

Query: 902 LAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSAT 961
                              R   + A  P P  P +AP+     P+S       PR    
Sbjct: 915 KD-----------------RATNSKATTPKPQKPTKAPK----KPTSTKKPKTMPRVRKP 953

Query: 962 RT 963
           +T
Sbjct: 954 KT 955



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 129/564 (22%), Positives = 185/564 (32%), Gaps = 90/564 (15%)

Query: 94  QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQE- 152
           + P+P   +  +P +P  P P     P P  P   + P                P T+E 
Sbjct: 340 KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP---KEP---------------APTTKEP 381

Query: 153 KPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA---A 209
            P  P+   PT P  P     +     +P EPAPT    PS    +  +P+    A    
Sbjct: 382 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 441

Query: 210 LQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKS 269
            +P P      P  P  P P       P P    E   TT  + A     + A +  +  
Sbjct: 442 KEPAPTTTKSAPTTPKEPSP--TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-- 497

Query: 270 IKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPP 329
            + A T  +  A      P P +      +      KK T  +    A T  E+     P
Sbjct: 498 -EPAPTTTKKPAPTTPKEPAPTTPK----ETAPTTPKKLTPTTPEKLAPTTPEKP---AP 549

Query: 330 TSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQ 389
           T+  EL      +    T     + P      A A +   E   +               
Sbjct: 550 TTPEELAPTTPEEPTPTTP----EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------ 599

Query: 390 LFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS--- 446
                ++ A ++ +E A   P        L+ P       P    L P+    P ++   
Sbjct: 600 ----PKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD 654

Query: 447 -PRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            P P  P G APT    PAP+     A P TP  +G  PTT      P  PK+       
Sbjct: 655 KPAPTTPKGTAPTTPKEPAPTTPKEPA-PTTP--KGTAPTTLKEP-APTTPKK------- 703

Query: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTP 561
             PAP            P+ T G  S      +P+TP+ + P T       PAP+ P  P
Sbjct: 704 --PAPKEL--------APTTTKGPTSTTSDKPAPTTPKETAPTTPKE----PAPTTPKKP 749

Query: 562 G-GAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAAR 620
               PE P P ++   T T +     P      P+   P   A   P A E     P   
Sbjct: 750 APTTPETPPPTTSEVSTPTTT---KEPTTIHKSPDESTPELSAEPTPKALENSPKEP--- 803

Query: 621 TGILQEARRRGTRKQMFRPGKEET 644
            G+        T+ +M    K++T
Sbjct: 804 -GVPTTKTPAATKPEMTTTAKDKT 826



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 113/501 (22%), Positives = 159/501 (31%), Gaps = 95/501 (18%)

Query: 457 PTPAPSIFNRSARPFTPG-LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP--PPFLSSQ 513
           PTP P + + +      G  +   P T++     ++      +   ++P P  PP   + 
Sbjct: 119 PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 178

Query: 514 GPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP--APP 571
             T L             + +     + G    TS+    +  +      AP     A P
Sbjct: 179 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 238

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           +  A T+T    L+ P  P+   P+ PA   P  P P + +    S P            
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK----SAPT----------- 283

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQP 689
             T K+   P    TK++P            E      A + P+E A +   E      P
Sbjct: 284 --TPKE---PAPTTTKSAPTTPKEPAPTTTKEP-----APTTPKEPAPTTTKEPA----P 329

Query: 690 VGARSYKTLPH----VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASS 745
              +S  T P      TPK P P  PK P P TPK P P  PK P+            + 
Sbjct: 330 TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA----------PTTK 379

Query: 746 AGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNI 805
              P  P+          +    A +     TP       P+ P+PT +  PS   +P  
Sbjct: 380 EPAPTTPK----------EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKE 428

Query: 806 RAPPPIAYNPLLS----PFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAM 861
            AP      P  +    P   ++A T PK  S      P                     
Sbjct: 429 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP------------------- 469

Query: 862 FCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWR 921
                 P  P P     P     +E      PAP    EP APT     A TT  EP   
Sbjct: 470 ----TTPKEPAPTTPKKPAPTTPKE------PAPTTPKEP-APTTTKKPAPTTPKEPAPT 518

Query: 922 TELASAPVPSPAPPPEAPRGL 942
           T   +AP       P  P  L
Sbjct: 519 TPKETAPTTPKKLTPTTPEKL 539



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 84/210 (40%), Gaps = 42/210 (20%)

Query: 94  QSPSPHELQVLSPLSPLSPEP--PGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
           + P+P   +  +P +   P P  P  P P+ L P + + P         T + +D PA  
Sbjct: 678 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP---------TSTTSDKPA-- 726

Query: 152 EKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSP-SWEDGAAL 210
             P  P+   PT P  P AP        +P +PAPT P  P    S VS+P + ++   +
Sbjct: 727 --PTTPKETAPTTPKEP-AP-------TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTI 776

Query: 211 QPPPAEAL----------LLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
              P E+            L + P  PG   +P     P     ++TTT   K  +  L+
Sbjct: 777 HKSPDESTPELSAEPTPKALENSPKEPG---VPTT-KTPAATKPEMTTTAKDKTTERDLR 832

Query: 261 ---RAESLQEKSIKE-AKTKCRTIASLLTA 286
                 +   K  KE A T  +T  S +TA
Sbjct: 833 TTPETTTAAPKMTKETATTTEKTTESKITA 862



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 26/193 (13%)

Query: 105 SPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR 164
           +P +P  P P     P P  P   + P  +      T  +     T+  P  P+   PT 
Sbjct: 296 APTTPKEPAPTTTKEPAPTTP---KEPAPT------TTKEPAPTTTKSAPTTPKEPAPTT 346

Query: 165 PTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP----PPAEALLL 220
           P  P AP        +P EPAPT P  P+    +  +P+ ++ A   P    P A     
Sbjct: 347 PKKP-APT-------TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 398

Query: 221 PHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQE---KSIKEAKTKC 277
           P  P  P P       P P    E   TT  + A         + +E    + K A T  
Sbjct: 399 PTTPKEPAP--TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 456

Query: 278 RTIASLLTAAPNP 290
           +  +   T  P P
Sbjct: 457 KEPSPTTTKEPAP 469



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 41/172 (23%), Positives = 60/172 (34%), Gaps = 11/172 (6%)

Query: 83  TVQRLADEGPVQSPSPHELQVLSPLSP-----LSPEPPGAPVPQPLQPGSLRSPPDSEAY 137
           T ++LA   P + P+P   + L+P +P      +PE P    P+   P + + P  +   
Sbjct: 535 TPEKLAPTTP-EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 593

Query: 138 YGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDS 197
                +  +   T  K   P     T PT    P        +P E APT    P+    
Sbjct: 594 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 653

Query: 198 RVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTT 249
              +P+   G A   P   A   P  P    P      G  P  + E   TT
Sbjct: 654 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK-----GTAPTTLKEPAPTT 700


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/575 (24%), Positives = 201/575 (34%), Gaps = 115/575 (20%)

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQE-LARVEPAA--MLNGEGLQSPPRAQSAPPE--A 432
           G+    S +  Q  E+   +  + T + LA+  P A     G  L +P       P+  A
Sbjct: 259 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 318

Query: 433 AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
           +  P  P P  + S  P  P   APT   S       P TP  +   PTTT     P  P
Sbjct: 319 STTPKEPTPTTIKSA-PTTPKEPAPTTTKSA------PTTP--KEPAPTTTKEP-APTTP 368

Query: 493 KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           K          PAP     +    P P+ T   P+  P   +P+TP+   P T       
Sbjct: 369 KE---------PAP-----TTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKE---- 409

Query: 553 PAPSRPVTPGGA-PEPPAPPSAA-AMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPS 608
           PAP+ P  P    P+ PAP +   A T+      +AP +P+   P+ PAP  P  P P +
Sbjct: 410 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 469

Query: 609 AREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGA 668
            +E   + P                     P    TK++P            ++P     
Sbjct: 470 TKEPSPTTPK-------------------EPAPTTTKSAPTTT---------KEPAPTTT 501

Query: 669 ESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 728
           +S P               +P    + +  P  TPK P P  PK P P TPK P P  PK
Sbjct: 502 KSAPTTPK-----------EPSPTTTKEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPK 549

Query: 729 PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS 788
            P           A ++   P P   +        +      + +   TP       P  
Sbjct: 550 EP-----------APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK 598

Query: 789 PSPTP--SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKA 846
           P+PT    L P+    P    P   A      P  P+AA   P    +    TPK+    
Sbjct: 599 PAPTTPEELAPTTPEEPTPTTPEEPA------PTTPKAAA--PNTPKEPAPTTPKEPA-- 648

Query: 847 LDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ-PTAEPLAPT 905
                  P   K      +  P TP   A  +PK      ++  +   P+ P  + LAPT
Sbjct: 649 -------PTTPK------EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 695

Query: 906 VLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPR 940
                 +TT D+P   T   +AP     P P  P+
Sbjct: 696 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 730



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 144/558 (25%), Positives = 200/558 (35%), Gaps = 77/558 (13%)

Query: 395 RQRADSSTQELARV---EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQ 451
           ++ A ++T+E A     EPA     E   +P   +SAP      P  P P     P P  
Sbjct: 353 KEPAPTTTKEPAPTTPKEPAPTTTKE--PAPTTTKSAP----TTPKEPAPTTPKKPAPTT 406

Query: 452 PGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
           P   APT        + +   P  +   PTT      P APK+   +    +P  P   +
Sbjct: 407 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTAPKKPAPT----TPKEPAPTT 461

Query: 512 SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            + P P    T+  PS       P+TP+   P T  S+        P T   AP  P  P
Sbjct: 462 PKEPAPT---TTKEPS-------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 511

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           S    T+T     + P  P+   P+ PAP  P  P P + +E   +          +   
Sbjct: 512 SP---TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 568

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM-- 687
             T K+   P   +      PE   L     EKP    A + PEE A +   E       
Sbjct: 569 PTTPKET-APTTPKKLTPTTPE--KLAPTTPEKP----APTTPEELAPTTPEEPTPTTPE 621

Query: 688 QPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG 747
           +P         P+ TPK P P  PK P P TPK P P  PK  +     G    A ++  
Sbjct: 622 EPAPTTPKAAAPN-TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT---APTTLK 677

Query: 748 IPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP----GLGP-RPRSPSPTPSLPPSWKYS 802
            P P   +    +  A   ++         P P    G  P  P+ P+PT    P+   +
Sbjct: 678 EPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA-PTT 736

Query: 803 PNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMF 862
           P   AP  +      +P  P A + L    ++GP +T           +  P   K    
Sbjct: 737 PKGTAPTTLKEPAPTTPKKP-APKELAPTTTKGPTSTTSD--------KPAPTTPK---- 783

Query: 863 CFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEP--IW 920
             +  P TP   A  +PK            PAP  T E   PT       TT  EP  I 
Sbjct: 784 --ETAPTTPKEPAPTTPK-----------KPAP-TTPETPPPTTSEVSTPTTTKEPTTIH 829

Query: 921 RTELASAPVPSPAPPPEA 938
           ++   S P  S  P P+A
Sbjct: 830 KSPDESTPELSAEPTPKA 847



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 179/842 (21%), Positives = 267/842 (31%), Gaps = 137/842 (16%)

Query: 150  TQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAA 209
            T  K   P  +   +PTP      +     +P EP PT P  P+    +  +P+    A 
Sbjct: 275  TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 334

Query: 210  L---QPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKA----KQAKLQRA 262
                +P P      P  P  P P       P P    E   TT  + A    K A     
Sbjct: 335  TTPKEPAPTTTKSAPTTPKEPAP--TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 392

Query: 263  ESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAE 322
            E       K A T  +  A      P P +      K+     K+    +    A T  +
Sbjct: 393  EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-----KEPAPTTKEPAPTTPKEPAPTAPK 447

Query: 323  EEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE 382
            +    P T +          A + T +    SP    E A   +++              
Sbjct: 448  KP--APTTPKEPAPTTPKEPAPTTTKE---PSPTTPKEPAPTTTKS-------------- 488

Query: 383  VSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA 442
                           A ++T+E A   P    +       P   +    A   P  P P 
Sbjct: 489  ---------------APTTTKEPA---PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530

Query: 443  PVASPRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
                P P  P   APT    PAP+   + A P TP  +   PTT      P  PK+    
Sbjct: 531  TPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTP--KEPAPTTPKET-APTTPKK---- 582

Query: 499  LGGLSPAPPPFLSSQGP-TPLPSFTSGVPSHAPVSGSPSTPRSSGPVT----ATSSLYIP 553
               L+P  P  L+   P  P P+    +    P   +P+TP    P T    A ++   P
Sbjct: 583  ---LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 639

Query: 554  APSRPVTPG-GAPEPPAP--PSAAAMTS---TASIFLSAPLRPSARPEAPAP---GPGAP 604
            AP+ P  P    P+ PAP  P   A T+   TA   L  P      P+ PAP    P   
Sbjct: 640  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP--APTTPKKPAPKELAPTTT 697

Query: 605  EPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR 664
            + P++       P    G      +         P     K +    L        +KP 
Sbjct: 698  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP- 756

Query: 665  AGGAESGPEEDA--LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP 722
                   P+E A   + G  +    +P      +T P  TPK P P  PK P P TP+TP
Sbjct: 757  ------APKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPAPTTPKKPAPTTPETP 809

Query: 723  PPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGL 782
            PP   +              ++     EP  +     E   +  +      +E +P    
Sbjct: 810  PPTTSE-------------VSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 856

Query: 783  GPRPRSPSPT-PSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPK 841
             P  ++P+ T P +  + K     R           +P   +   T  +  ++       
Sbjct: 857  VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 916

Query: 842  QGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEP 901
              + +       P+++ T          T  P  + + KT    EI       P+ TA+P
Sbjct: 917  TQVTSTTTQDTTPFKITTLK------TTTLAPKVTTTKKTITTTEIMN----KPEETAKP 966

Query: 902  LAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSAT 961
                               R   + A  P P  P +AP+     P+S       PR    
Sbjct: 967  KD-----------------RATNSKATTPKPQKPTKAPK----KPTSTKKPKTMPRVRKP 1005

Query: 962  RT 963
            +T
Sbjct: 1006 KT 1007



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 129/564 (22%), Positives = 185/564 (32%), Gaps = 90/564 (15%)

Query: 94  QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQE- 152
           + P+P   +  +P +P  P P     P P  P   + P                P T+E 
Sbjct: 392 KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP---KEP---------------APTTKEP 433

Query: 153 KPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA---A 209
            P  P+   PT P  P     +     +P EPAPT    PS    +  +P+    A    
Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 210 LQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKS 269
            +P P      P  P  P P       P P    E   TT  + A     + A +  +  
Sbjct: 494 KEPAPTTTKSAPTTPKEPSP--TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-- 549

Query: 270 IKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPP 329
            + A T  +  A      P P +      +      KK T  +    A T  E+     P
Sbjct: 550 -EPAPTTTKKPAPTTPKEPAPTTPK----ETAPTTPKKLTPTTPEKLAPTTPEKP---AP 601

Query: 330 TSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQ 389
           T+  EL      +    T     + P      A A +   E   +               
Sbjct: 602 TTPEELAPTTPEEPTPTTP----EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------ 651

Query: 390 LFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS--- 446
                ++ A ++ +E A   P        L+ P       P    L P+    P ++   
Sbjct: 652 ----PKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD 706

Query: 447 -PRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            P P  P G APT    PAP+     A P TP  +G  PTT      P  PK+       
Sbjct: 707 KPAPTTPKGTAPTTPKEPAPTTPKEPA-PTTP--KGTAPTTLKEP-APTTPKK------- 755

Query: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTP 561
             PAP            P+ T G  S      +P+TP+ + P T       PAP+ P  P
Sbjct: 756 --PAPKEL--------APTTTKGPTSTTSDKPAPTTPKETAPTTPKE----PAPTTPKKP 801

Query: 562 G-GAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAAR 620
               PE P P ++   T T +     P      P+   P   A   P A E     P   
Sbjct: 802 APTTPETPPPTTSEVSTPTTT---KEPTTIHKSPDESTPELSAEPTPKALENSPKEP--- 855

Query: 621 TGILQEARRRGTRKQMFRPGKEET 644
            G+        T+ +M    K++T
Sbjct: 856 -GVPTTKTPAATKPEMTTTAKDKT 878



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 113/501 (22%), Positives = 159/501 (31%), Gaps = 95/501 (18%)

Query: 457 PTPAPSIFNRSARPFTPG-LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP--PPFLSSQ 513
           PTP P + + +      G  +   P T++     ++      +   ++P P  PP   + 
Sbjct: 171 PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 230

Query: 514 GPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP--APP 571
             T L             + +     + G    TS+    +  +      AP     A P
Sbjct: 231 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 290

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           +  A T+T    L+ P  P+   P+ PA   P  P P + +    S P            
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK----SAPT----------- 335

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQP 689
             T K+   P    TK++P            E      A + P+E A +   E      P
Sbjct: 336 --TPKE---PAPTTTKSAPTTPKEPAPTTTKEP-----APTTPKEPAPTTTKEPA----P 381

Query: 690 VGARSYKTLPH----VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASS 745
              +S  T P      TPK P P  PK P P TPK P P  PK P+            + 
Sbjct: 382 TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA----------PTTK 431

Query: 746 AGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNI 805
              P  P+          +    A +     TP       P+ P+PT +  PS   +P  
Sbjct: 432 EPAPTTPK----------EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKE 480

Query: 806 RAPPPIAYNPLLS----PFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAM 861
            AP      P  +    P   ++A T PK  S      P                     
Sbjct: 481 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP------------------- 521

Query: 862 FCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWR 921
                 P  P P     P     +E      PAP    EP APT     A TT  EP   
Sbjct: 522 ----TTPKEPAPTTPKKPAPTTPKE------PAPTTPKEP-APTTTKKPAPTTPKEPAPT 570

Query: 922 TELASAPVPSPAPPPEAPRGL 942
           T   +AP       P  P  L
Sbjct: 571 TPKETAPTTPKKLTPTTPEKL 591



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 84/210 (40%), Gaps = 42/210 (20%)

Query: 94  QSPSPHELQVLSPLSPLSPEP--PGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
           + P+P   +  +P +   P P  P  P P+ L P + + P         T + +D PA  
Sbjct: 730 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP---------TSTTSDKPA-- 778

Query: 152 EKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSP-SWEDGAAL 210
             P  P+   PT P  P AP        +P +PAPT P  P    S VS+P + ++   +
Sbjct: 779 --PTTPKETAPTTPKEP-AP-------TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTI 828

Query: 211 QPPPAEAL----------LLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
              P E+            L + P  PG   +P     P     ++TTT   K  +  L+
Sbjct: 829 HKSPDESTPELSAEPTPKALENSPKEPG---VPTT-KTPAATKPEMTTTAKDKTTERDLR 884

Query: 261 ---RAESLQEKSIKE-AKTKCRTIASLLTA 286
                 +   K  KE A T  +T  S +TA
Sbjct: 885 TTPETTTAAPKMTKETATTTEKTTESKITA 914



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 26/193 (13%)

Query: 105 SPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR 164
           +P +P  P P     P P  P   + P  +      T  +     T+  P  P+   PT 
Sbjct: 348 APTTPKEPAPTTTKEPAPTTP---KEPAPT------TTKEPAPTTTKSAPTTPKEPAPTT 398

Query: 165 PTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP----PPAEALLL 220
           P  P AP        +P EPAPT P  P+    +  +P+ ++ A   P    P A     
Sbjct: 399 PKKP-APT-------TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 450

Query: 221 PHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQE---KSIKEAKTKC 277
           P  P  P P       P P    E   TT  + A         + +E    + K A T  
Sbjct: 451 PTTPKEPAP--TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 508

Query: 278 RTIASLLTAAPNP 290
           +  +   T  P P
Sbjct: 509 KEPSPTTTKEPAP 521



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 41/172 (23%), Positives = 60/172 (34%), Gaps = 11/172 (6%)

Query: 83  TVQRLADEGPVQSPSPHELQVLSPLSP-----LSPEPPGAPVPQPLQPGSLRSPPDSEAY 137
           T ++LA   P + P+P   + L+P +P      +PE P    P+   P + + P  +   
Sbjct: 587 TPEKLAPTTP-EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 645

Query: 138 YGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDS 197
                +  +   T  K   P     T PT    P        +P E APT    P+    
Sbjct: 646 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 705

Query: 198 RVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTT 249
              +P+   G A   P   A   P  P    P      G  P  + E   TT
Sbjct: 706 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK-----GTAPTTLKEPAPTT 752



 Score = 30.8 bits (68), Expect = 6.5
 Identities = 78/395 (19%), Positives = 116/395 (29%), Gaps = 31/395 (7%)

Query: 558 PVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVP 617
           P +P  + + P PPS A+ T  ++   S       + +         E  S  E + S  
Sbjct: 69  PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSS 127

Query: 618 AARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDAL 677
           ++ +       R+       +  K    N    + L +  N   + +       P  D  
Sbjct: 128 SSSSSSSSSTIRK------IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEA 181

Query: 678 SLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP-PPVAPKPPSRGLLD 736
             G +  +F   V      T  H    T P +   T  P+ P+   PP +       L  
Sbjct: 182 GSGLDNGDFK--VTTPDTSTTQHNKVSTSPKIT--TAKPINPRPSLPPNSDTSKETSLTV 237

Query: 737 GLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS-PSPTPSL 795
                  +        +    G E   K  S  +   +E T    L P  +    PTP  
Sbjct: 238 NKETTVETKETTTTNKQTSTDGKE---KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKA 294

Query: 796 PPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPY 855
             + K  P +  P          P         P      P  TPK+           P 
Sbjct: 295 ETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP-TTPKEPA---------PT 343

Query: 856 QLKTAMFCFDEVPPT----PGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRA 911
             K+A     E  PT    P P     P     +E    +T +   T +  APT     A
Sbjct: 344 TTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA 403

Query: 912 ATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASP 946
            TT  EP   T     P     P P        +P
Sbjct: 404 PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTP 438


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/575 (24%), Positives = 201/575 (34%), Gaps = 115/575 (20%)

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQE-LARVEPAA--MLNGEGLQSPPRAQSAPPE--A 432
           G+    S +  Q  E+   +  + T + LA+  P A     G  L +P       P+  A
Sbjct: 300 GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA 359

Query: 433 AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
           +  P  P P  + S  P  P   APT   S       P TP  +   PTTT     P  P
Sbjct: 360 STTPKEPTPTTIKSA-PTTPKEPAPTTTKSA------PTTP--KEPAPTTTKEP-APTTP 409

Query: 493 KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           K          PAP     +    P P+ T   P+  P   +P+TP+   P T       
Sbjct: 410 KE---------PAP-----TTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKE---- 450

Query: 553 PAPSRPVTPGGA-PEPPAPPSAA-AMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPS 608
           PAP+ P  P    P+ PAP +   A T+      +AP +P+   P+ PAP  P  P P +
Sbjct: 451 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 510

Query: 609 AREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGA 668
            +E   + P                     P    TK++P            ++P     
Sbjct: 511 TKEPSPTTPK-------------------EPAPTTTKSAPTTT---------KEPAPTTT 542

Query: 669 ESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 728
           +S P               +P    + +  P  TPK P P  PK P P TPK P P  PK
Sbjct: 543 KSAPTTPK-----------EPSPTTTKEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPK 590

Query: 729 PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS 788
            P           A ++   P P   +        +      + +   TP       P  
Sbjct: 591 EP-----------APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEK 639

Query: 789 PSPTP--SLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKA 846
           P+PT    L P+    P    P   A      P  P+AA   P    +    TPK+    
Sbjct: 640 PAPTTPEELAPTTPEEPTPTTPEEPA------PTTPKAAA--PNTPKEPAPTTPKEPA-- 689

Query: 847 LDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ-PTAEPLAPT 905
                  P   K      +  P TP   A  +PK      ++  +   P+ P  + LAPT
Sbjct: 690 -------PTTPK------EPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 736

Query: 906 VLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPR 940
                 +TT D+P   T   +AP     P P  P+
Sbjct: 737 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 771



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 144/558 (25%), Positives = 200/558 (35%), Gaps = 77/558 (13%)

Query: 395 RQRADSSTQELARV---EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQ 451
           ++ A ++T+E A     EPA     E   +P   +SAP      P  P P     P P  
Sbjct: 394 KEPAPTTTKEPAPTTPKEPAPTTTKE--PAPTTTKSAP----TTPKEPAPTTPKKPAPTT 447

Query: 452 PGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
           P   APT        + +   P  +   PTT      P APK+   +    +P  P   +
Sbjct: 448 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTAPKKPAPT----TPKEPAPTT 502

Query: 512 SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
            + P P    T+  PS       P+TP+   P T  S+        P T   AP  P  P
Sbjct: 503 PKEPAPT---TTKEPS-------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 552

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           S    T+T     + P  P+   P+ PAP  P  P P + +E   +          +   
Sbjct: 553 SP---TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 609

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM-- 687
             T K+   P   +      PE   L     EKP    A + PEE A +   E       
Sbjct: 610 PTTPKET-APTTPKKLTPTTPE--KLAPTTPEKP----APTTPEELAPTTPEEPTPTTPE 662

Query: 688 QPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG 747
           +P         P+ TPK P P  PK P P TPK P P  PK  +     G    A ++  
Sbjct: 663 EPAPTTPKAAAPN-TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT---APTTLK 718

Query: 748 IPEPPRLQGRGGELFAKRQSRADRYVVEGTPGP----GLGP-RPRSPSPTPSLPPSWKYS 802
            P P   +    +  A   ++         P P    G  P  P+ P+PT    P+   +
Sbjct: 719 EPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA-PTT 777

Query: 803 PNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMF 862
           P   AP  +      +P  P A + L    ++GP +T           +  P   K    
Sbjct: 778 PKGTAPTTLKEPAPTTPKKP-APKELAPTTTKGPTSTTSD--------KPAPTTPK---- 824

Query: 863 CFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEP--IW 920
             +  P TP   A  +PK            PAP  T E   PT       TT  EP  I 
Sbjct: 825 --ETAPTTPKEPAPTTPK-----------KPAP-TTPETPPPTTSEVSTPTTTKEPTTIH 870

Query: 921 RTELASAPVPSPAPPPEA 938
           ++   S P  S  P P+A
Sbjct: 871 KSPDESTPELSAEPTPKA 888



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 179/842 (21%), Positives = 267/842 (31%), Gaps = 137/842 (16%)

Query: 150  TQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAA 209
            T  K   P  +   +PTP      +     +P EP PT P  P+    +  +P+    A 
Sbjct: 316  TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 375

Query: 210  L---QPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKA----KQAKLQRA 262
                +P P      P  P  P P       P P    E   TT  + A    K A     
Sbjct: 376  TTPKEPAPTTTKSAPTTPKEPAP--TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 433

Query: 263  ESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAE 322
            E       K A T  +  A      P P +      K+     K+    +    A T  +
Sbjct: 434  EPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-----KEPAPTTKEPAPTTPKEPAPTAPK 488

Query: 323  EEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE 382
            +    P T +          A + T +    SP    E A   +++              
Sbjct: 489  KP--APTTPKEPAPTTPKEPAPTTTKE---PSPTTPKEPAPTTTKS-------------- 529

Query: 383  VSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA 442
                           A ++T+E A   P    +       P   +    A   P  P P 
Sbjct: 530  ---------------APTTTKEPA---PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571

Query: 443  PVASPRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
                P P  P   APT    PAP+   + A P TP  +   PTT      P  PK+    
Sbjct: 572  TPKKPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTP--KEPAPTTPKET-APTTPKK---- 623

Query: 499  LGGLSPAPPPFLSSQGP-TPLPSFTSGVPSHAPVSGSPSTPRSSGPVT----ATSSLYIP 553
               L+P  P  L+   P  P P+    +    P   +P+TP    P T    A ++   P
Sbjct: 624  ---LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 680

Query: 554  APSRPVTPG-GAPEPPAP--PSAAAMTS---TASIFLSAPLRPSARPEAPAP---GPGAP 604
            AP+ P  P    P+ PAP  P   A T+   TA   L  P      P+ PAP    P   
Sbjct: 681  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP--APTTPKKPAPKELAPTTT 738

Query: 605  EPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR 664
            + P++       P    G      +         P     K +    L        +KP 
Sbjct: 739  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP- 797

Query: 665  AGGAESGPEEDA--LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP 722
                   P+E A   + G  +    +P      +T P  TPK P P  PK P P TP+TP
Sbjct: 798  ------APKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPAPTTPKKPAPTTPETP 850

Query: 723  PPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGL 782
            PP   +              ++     EP  +     E   +  +      +E +P    
Sbjct: 851  PPTTSE-------------VSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 897

Query: 783  GPRPRSPSPT-PSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPK 841
             P  ++P+ T P +  + K     R           +P   +   T  +  ++       
Sbjct: 898  VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 957

Query: 842  QGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEP 901
              + +       P+++ T          T  P  + + KT    EI       P+ TA+P
Sbjct: 958  TQVTSTTTQDTTPFKITTLK------TTTLAPKVTTTKKTITTTEIMN----KPEETAKP 1007

Query: 902  LAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSAT 961
                               R   + A  P P  P +AP+     P+S       PR    
Sbjct: 1008 KD-----------------RATNSKATTPKPQKPTKAPK----KPTSTKKPKTMPRVRKP 1046

Query: 962  RT 963
            +T
Sbjct: 1047 KT 1048



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 129/564 (22%), Positives = 185/564 (32%), Gaps = 90/564 (15%)

Query: 94  QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQE- 152
           + P+P   +  +P +P  P P     P P  P   + P                P T+E 
Sbjct: 433 KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP---KEP---------------APTTKEP 474

Query: 153 KPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA---A 209
            P  P+   PT P  P     +     +P EPAPT    PS    +  +P+    A    
Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 210 LQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKS 269
            +P P      P  P  P P       P P    E   TT  + A     + A +  +  
Sbjct: 535 KEPAPTTTKSAPTTPKEPSP--TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-- 590

Query: 270 IKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPP 329
            + A T  +  A      P P +      +      KK T  +    A T  E+     P
Sbjct: 591 -EPAPTTTKKPAPTTPKEPAPTTPK----ETAPTTPKKLTPTTPEKLAPTTPEKP---AP 642

Query: 330 TSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQ 389
           T+  EL      +    T     + P      A A +   E   +               
Sbjct: 643 TTPEELAPTTPEEPTPTTP----EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------ 692

Query: 390 LFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS--- 446
                ++ A ++ +E A   P        L+ P       P    L P+    P ++   
Sbjct: 693 ----PKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCD 747

Query: 447 -PRPFQPGGGAPT----PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            P P  P G APT    PAP+     A P TP  +G  PTT      P  PK+       
Sbjct: 748 KPAPTTPKGTAPTTPKEPAPTTPKEPA-PTTP--KGTAPTTLKEP-APTTPKK------- 796

Query: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTP 561
             PAP            P+ T G  S      +P+TP+ + P T       PAP+ P  P
Sbjct: 797 --PAPKEL--------APTTTKGPTSTTSDKPAPTTPKETAPTTPKE----PAPTTPKKP 842

Query: 562 G-GAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAAR 620
               PE P P ++   T T +     P      P+   P   A   P A E     P   
Sbjct: 843 APTTPETPPPTTSEVSTPTTT---KEPTTIHKSPDESTPELSAEPTPKALENSPKEP--- 896

Query: 621 TGILQEARRRGTRKQMFRPGKEET 644
            G+        T+ +M    K++T
Sbjct: 897 -GVPTTKTPAATKPEMTTTAKDKT 919



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 113/501 (22%), Positives = 159/501 (31%), Gaps = 95/501 (18%)

Query: 457 PTPAPSIFNRSARPFTPG-LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP--PPFLSSQ 513
           PTP P + + +      G  +   P T++     ++      +   ++P P  PP   + 
Sbjct: 212 PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 271

Query: 514 GPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP--APP 571
             T L             + +     + G    TS+    +  +      AP     A P
Sbjct: 272 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 331

Query: 572 SAAAMTSTASIFLSAPLRPS-ARPEAPAPG-PGAPEPPSAREQRISVPAARTGILQEARR 629
           +  A T+T    L+ P  P+   P+ PA   P  P P + +    S P            
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK----SAPT----------- 376

Query: 630 RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQP 689
             T K+   P    TK++P            E      A + P+E A +   E      P
Sbjct: 377 --TPKE---PAPTTTKSAPTTPKEPAPTTTKEP-----APTTPKEPAPTTTKEPA----P 422

Query: 690 VGARSYKTLPH----VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASS 745
              +S  T P      TPK P P  PK P P TPK P P  PK P+            + 
Sbjct: 423 TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA----------PTTK 472

Query: 746 AGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNI 805
              P  P+          +    A +     TP       P+ P+PT +  PS   +P  
Sbjct: 473 EPAPTTPK----------EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKE 521

Query: 806 RAPPPIAYNPLLS----PFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAM 861
            AP      P  +    P   ++A T PK  S      P                     
Sbjct: 522 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP------------------- 562

Query: 862 FCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWR 921
                 P  P P     P     +E      PAP    EP APT     A TT  EP   
Sbjct: 563 ----TTPKEPAPTTPKKPAPTTPKE------PAPTTPKEP-APTTTKKPAPTTPKEPAPT 611

Query: 922 TELASAPVPSPAPPPEAPRGL 942
           T   +AP       P  P  L
Sbjct: 612 TPKETAPTTPKKLTPTTPEKL 632



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 84/210 (40%), Gaps = 42/210 (20%)

Query: 94  QSPSPHELQVLSPLSPLSPEP--PGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
           + P+P   +  +P +   P P  P  P P+ L P + + P         T + +D PA  
Sbjct: 771 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP---------TSTTSDKPA-- 819

Query: 152 EKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSP-SWEDGAAL 210
             P  P+   PT P  P AP        +P +PAPT P  P    S VS+P + ++   +
Sbjct: 820 --PTTPKETAPTTPKEP-AP-------TTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTI 869

Query: 211 QPPPAEAL----------LLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
              P E+            L + P  PG   +P     P     ++TTT   K  +  L+
Sbjct: 870 HKSPDESTPELSAEPTPKALENSPKEPG---VPTT-KTPAATKPEMTTTAKDKTTERDLR 925

Query: 261 ---RAESLQEKSIKE-AKTKCRTIASLLTA 286
                 +   K  KE A T  +T  S +TA
Sbjct: 926 TTPETTTAAPKMTKETATTTEKTTESKITA 955



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 26/193 (13%)

Query: 105 SPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR 164
           +P +P  P P     P P  P   + P  +      T  +     T+  P  P+   PT 
Sbjct: 389 APTTPKEPAPTTTKEPAPTTP---KEPAPT------TTKEPAPTTTKSAPTTPKEPAPTT 439

Query: 165 PTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP----PPAEALLL 220
           P  P AP        +P EPAPT P  P+    +  +P+ ++ A   P    P A     
Sbjct: 440 PKKP-APT-------TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 491

Query: 221 PHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQE---KSIKEAKTKC 277
           P  P  P P       P P    E   TT  + A         + +E    + K A T  
Sbjct: 492 PTTPKEPAP--TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 549

Query: 278 RTIASLLTAAPNP 290
           +  +   T  P P
Sbjct: 550 KEPSPTTTKEPAP 562



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 41/172 (23%), Positives = 60/172 (34%), Gaps = 11/172 (6%)

Query: 83  TVQRLADEGPVQSPSPHELQVLSPLSP-----LSPEPPGAPVPQPLQPGSLRSPPDSEAY 137
           T ++LA   P + P+P   + L+P +P      +PE P    P+   P + + P  +   
Sbjct: 628 TPEKLAPTTP-EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 686

Query: 138 YGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDS 197
                +  +   T  K   P     T PT    P        +P E APT    P+    
Sbjct: 687 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 746

Query: 198 RVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTT 249
              +P+   G A   P   A   P  P    P      G  P  + E   TT
Sbjct: 747 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK-----GTAPTTLKEPAPTT 793



 Score = 30.8 bits (68), Expect = 6.5
 Identities = 78/395 (19%), Positives = 116/395 (29%), Gaps = 31/395 (7%)

Query: 558 PVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVP 617
           P +P  + + P PPS A+ T  ++   S       + +         E  S  E + S  
Sbjct: 110 PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSS 168

Query: 618 AARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDAL 677
           ++ +       R+       +  K    N    + L +  N   + +       P  D  
Sbjct: 169 SSSSSSSSSTIRK------IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEA 222

Query: 678 SLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP-PPVAPKPPSRGLLD 736
             G +  +F   V      T  H    T P +   T  P+ P+   PP +       L  
Sbjct: 223 GSGLDNGDFK--VTTPDTSTTQHNKVSTSPKIT--TAKPINPRPSLPPNSDTSKETSLTV 278

Query: 737 GLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS-PSPTPSL 795
                  +        +    G E   K  S  +   +E T    L P  +    PTP  
Sbjct: 279 NKETTVETKETTTTNKQTSTDGKE---KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKA 335

Query: 796 PPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPY 855
             + K  P +  P          P         P      P  TPK+           P 
Sbjct: 336 ETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP-TTPKEPA---------PT 384

Query: 856 QLKTAMFCFDEVPPT----PGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRA 911
             K+A     E  PT    P P     P     +E    +T +   T +  APT     A
Sbjct: 385 TTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA 444

Query: 912 ATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASP 946
            TT  EP   T     P     P P        +P
Sbjct: 445 PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTP 479


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 145/551 (26%), Positives = 191/551 (34%), Gaps = 117/551 (21%)

Query: 411 AAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASP---RPFQPGGGAPTPAPSIFNRS 467
           A  L   G+Q  P+ ++   E   L P P  +P++ P    P  P   A   +P      
Sbjct: 416 AKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELP 475

Query: 468 ARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPS 527
           A P    L   RP   S    PL+P      L     +PPP   S   +PL       P 
Sbjct: 476 ASPLPEALHLSRPLEES----PLSPPPEESPL-----SPPP--ESSPFSPLEESPLSPPE 524

Query: 528 HAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAP 587
            +P S +  TP S  P    S L  P    P++P     P +PP  A+        LS P
Sbjct: 525 ESPPSPALETPLS--PPPEASPLSPPFEESPLSPPPEELPTSPPPEASR-------LSPP 575

Query: 588 LRPSARPEAPAPGPGAPEPPSAR------EQRISVPAARTGIL--QEARRRG--TRKQMF 637
              S     P   P +P P ++R      E  +S P   + +    EA R          
Sbjct: 576 PEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPM 635

Query: 638 RPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
            P  EE+  SP PE    V  L   P        PEE  LS                   
Sbjct: 636 SPPPEESPMSPPPE----VSRLSPLPVVSRLSPPPEESPLS------------------P 673

Query: 698 LPHVTPKTPPPMAPKTPPPM--TPKTPPP--VAPKPPSRGLLDGLVNGAASSAGIPEPPR 753
            P  +P +PPP A +  PP   +P +PPP      PP    L  L    +    +PE P+
Sbjct: 674 PPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQ 733

Query: 754 LQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSP--SPTPSLPPSWKYSPNIRAP--P 809
           L  R                   + GP L PRP  P  SP P  P     SP    P   
Sbjct: 734 LCPR-------------------SEGPHLSPRPEEPHLSPRPEEP---HLSPQAEEPHLS 771

Query: 810 PIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869
           P    P L    P+     P  Q++GP  +P            QP +L  +       P 
Sbjct: 772 PQPEEPCLCA-VPEEPHLSP--QAEGPHLSP------------QPEELHLS-------PQ 809

Query: 870 TPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPV 929
           T  P  S  P+   +         +PQP    L+P    P  +   +E     EL   P+
Sbjct: 810 TEEPHLSPVPEEPCL---------SPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPL 860

Query: 930 -PSPAPPPEAP 939
            P P  PPE P
Sbjct: 861 SPRPEKPPEEP 871



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 145/598 (24%), Positives = 205/598 (34%), Gaps = 126/598 (21%)

Query: 422  PPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNR--SARPFTPGLQG-- 477
            PP A    P    LP SPLP  +   RP +    +P P  S  +    + PF+P  +   
Sbjct: 461  PPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPL 520

Query: 478  ---QRPTTTSVIFRPLAPKRANDSLGGLSP-------APPPFLSSQGPTPLPSFTSGVPS 527
               +    +  +  PL+P         LSP       +PPP      P P  S  S  P 
Sbjct: 521  SPPEESPPSPALETPLSPP---PEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPE 577

Query: 528  HAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAP 587
             +P+S  P     S P  A S L+ P    P++P     P +PP  A+        LS P
Sbjct: 578  ESPMSPPPEESPMSPPPEA-SRLFPPFEESPLSPPPEESPLSPPPEASR-------LSPP 629

Query: 588  LRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS 647
               S     P   P +P P  +R   + V +  +   +E+           P  EE+  S
Sbjct: 630  PEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP--------LSPPPEESPTS 681

Query: 648  PNPELLSLVQNLDEKPRAGGAESGP-----EEDALSLGAEACNFMQ-----PVGARSYKT 697
            P PE   L    ++ P +   E  P     E+  +SL  E    +       +  RS   
Sbjct: 682  PPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEG- 740

Query: 698  LPHVTPKTPPPMAPKTP--PPMTPKTPPP-VAPKPPSRGLLDGLVNGAASSAGIPEPPRL 754
             PH++P+   P     P  P ++P+   P ++P+P    L             +PE P L
Sbjct: 741  -PHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCL-----------CAVPEEPHL 788

Query: 755  --QGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSP--SPTPS---------------L 795
              Q  G  L  + +   + ++   T  P L P P  P  SP P                 
Sbjct: 789  SPQAEGPHLSPQPE---ELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPR 845

Query: 796  PPSWKYSPNIRAPP--PIAYNPLLSPFFPQAARTLPKAQSQG-PRATPKQGIKALDFMRH 852
            P     SP +  PP  P    P   P    A   LP     G P  +P  G  AL     
Sbjct: 846  PEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGE 905

Query: 853  QPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLA---- 908
             P          +E+P +P    S SP+              P P   PL+P + A    
Sbjct: 906  PPLSPLP-----EELPLSPSGEPSLSPQLM-----------PPDPLPPPLSPIITAAAPP 949

Query: 909  ----------------------PRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGA 944
                                  P AA  L+ PI     A+   P P PP   P   G+
Sbjct: 950  ALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGS 1007



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 131/551 (23%), Positives = 190/551 (34%), Gaps = 82/551 (14%)

Query: 419  LQSPPRAQ--SAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQ 476
            L  PP A   S P E + L P P   P + P         P  +P        P +P   
Sbjct: 536  LSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP--- 592

Query: 477  GQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPS 536
               P   S +F P      +        +PPP  S   P P  S  S  P  +P+S  P 
Sbjct: 593  ---PPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPE 649

Query: 537  TPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEA 596
              R S P+   S L  P    P++P     P +PP  A+        LS P  P   P +
Sbjct: 650  VSRLS-PLPVVSRLSPPPEESPLSPPPEESPTSPPPEASR-------LSPP--PEDSPTS 699

Query: 597  PAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLV 656
            P P   +P  P   +  +S+P   + +L              P  EE +  P  E     
Sbjct: 700  PPP-EDSPASPPPEDSLMSLPLEESPLL--------------PLPEEPQLCPRSE----G 740

Query: 657  QNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTP-- 714
             +L  +P        PEE  LS  AE                PH++P+   P     P  
Sbjct: 741  PHLSPRPEEPHLSPRPEEPHLSPQAEE---------------PHLSPQPEEPCLCAVPEE 785

Query: 715  PPMTPKTP-PPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSR----- 768
            P ++P+   P ++P+P    L         S   +PE P L  +  E     QS      
Sbjct: 786  PHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP--VPEEPCLSPQPEESHLSPQSEEPCLS 843

Query: 769  ---ADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAA 825
                + ++      P L PRP  P   P   P+ +  P    PPP    P LSP   + A
Sbjct: 844  PRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLF--PPP--GEPSLSPLLGEPA 899

Query: 826  RTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPI--ASGSPKTAR 883
             + P      P   P++    L         L   +   D +PP   PI  A+  P  + 
Sbjct: 900  LSEPGEPPLSP--LPEE----LPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSP 953

Query: 884  VQEIR-----RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEA 938
            + E+      +  +    P A P+  T ++P       +P     +   P P     P +
Sbjct: 954  LGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPAS 1013

Query: 939  PRGLGASPSSC 949
            P  +   P  C
Sbjct: 1014 PILMEPLPPQC 1024



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 144/564 (25%), Positives = 190/564 (33%), Gaps = 94/564 (16%)

Query: 421  SPPRAQSA---PPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQG 477
            SPP  +S    PPEA+ L P P  +P++ P    P     +P P +   S  P    L  
Sbjct: 609  SPPPEESPLSPPPEASRLSPPPEDSPMSPP----PEESPMSPPPEVSRLSPLPVVSRLSP 664

Query: 478  QRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPST 537
              P   S    PL+P            +PPP  S   P P  S TS  P  +P S  P  
Sbjct: 665  --PPEES----PLSPPPEESPT-----SPPPEASRLSPPPEDSPTSPPPEDSPASPPPED 713

Query: 538  PRSSGPVTATSSLYIPAPS-------------RPVTPGGAPEPPAP---PSAA----AMT 577
               S P+  +  L +P                RP  P  +P P  P   P A     +  
Sbjct: 714  SLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQ 773

Query: 578  STASIFLSAPLRPSARPEAPAPGPGAPEP------PSAREQRISVPAARTGILQEARRRG 631
                   + P  P   P+A  P   +P+P      P   E  +S P      L       
Sbjct: 774  PEEPCLCAVPEEPHLSPQAEGPHL-SPQPEELHLSPQTEEPHLS-PVPEEPCLSPQ---- 827

Query: 632  TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVG 691
              +    P  EE   SP PE   L   L++ P +   E  PEE       E      P G
Sbjct: 828  PEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPG 887

Query: 692  ARSYKTL---PHVT-PKTPP--------PMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLV 739
              S   L   P ++ P  PP        P++P   P ++P+  PP    PP   ++    
Sbjct: 888  EPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAA 947

Query: 740  NGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSW 799
              A S  G  E P   G  G+   +    A       +P P        P P   LPPS 
Sbjct: 948  PPALSPLGELEYPF--GAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPS- 1004

Query: 800  KYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKT 859
              SP +    PI   PL     P    +L    S   + +P     AL            
Sbjct: 1005 PGSP-VGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPP----ALPL---------- 1049

Query: 860  AMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPI 919
                   VP    PI     K   V +         +  +EP  P  L P A + L  P+
Sbjct: 1050 ------SVPSPLSPIG----KVVGVSDEAELHEMETEKVSEPECPA-LEPSATSPLPSPM 1098

Query: 920  WRTELASAPVPSPAPPPEAPRGLG 943
                  S P PSPAP  +   GLG
Sbjct: 1099 GDL---SCPAPSPAPALDDFSGLG 1119



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 197/844 (23%), Positives = 287/844 (34%), Gaps = 172/844 (20%)

Query: 89   DEGPVQSPSPHELQVLSP-----LSPLSPEPPGAPVPQ------PLQPGSLRSPPDSEAY 137
            +E P+ SP P E     P     LSP   E P +P+P+      PL+   L  PP+    
Sbjct: 445  EESPL-SPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPL 503

Query: 138  YGETDSDADGPATQEKPRRPRRRGPTRP---TPPGAPPDEVYLS----DSPAEPAPT-IP 189
                +S    P  +E P  P    P  P   TP   PP+   LS    +SP  P P  +P
Sbjct: 504  SPPPESSPFSPL-EESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELP 562

Query: 190  GPPSQGDSRVSSPSWE-------DGAALQPPPAEALLLP---HGPLRPGPHLIPMVGPVP 239
              P    SR+S P  E       + + + PPP  + L P     PL P P   P+    P
Sbjct: 563  TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLS---P 619

Query: 240  HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFK 299
             P A  L+            +  ES      + ++     + S L+  P          +
Sbjct: 620  PPEASRLSPPPEDSPMSPPPE--ESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEE 677

Query: 300  KRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDM 359
                   + + +S         E+    PP  +S           SL  +   +SP L +
Sbjct: 678  SPTSPPPEASRLS------PPPEDSPTSPPPEDSPASPPPEDSLMSLPLE---ESPLLPL 728

Query: 360  ELARAGSRASEGQGSGLGGQLSEVSGRGVQ-----------LFEQQRQRADSSTQELARV 408
                     SEG       +   +S R  +           L  Q  +    +  E   +
Sbjct: 729  PEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHL 788

Query: 409  EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA-PVASPRPFQPGGGAPTPAPSIFNRS 467
             P A   G  L   P      P+      SP+P  P  SP+P +      +  P +   S
Sbjct: 789  SPQA--EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCL---S 843

Query: 468  ARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTP--LPSFTS-G 524
             RP    L  +          PL+P+          P  PP    Q P P  LP F   G
Sbjct: 844  PRPEESHLSPELEKP------PLSPR----------PEKPPEEPGQCPAPEELPLFPPPG 887

Query: 525  VPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSR-PVTPGGAP---------EPPAPPSAA 574
             PS +P+ G P+      P  +      P P   P++P G P         +P  PP + 
Sbjct: 888  EPSLSPLLGEPALSEPGEPPLS------PLPEELPLSPSGEPSLSPQLMPPDPLPPPLSP 941

Query: 575  AMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRK 634
             +T+ A   LS    P    E P    G  +P    E  ++ P   T I           
Sbjct: 942  IITAAAPPALS----PLGELEYPFGAKGDSDP----ESPLAAPILETPI----------- 982

Query: 635  QMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARS 694
                P  E     P P    ++      P + G+  GP    L         M+P+  + 
Sbjct: 983  ---SPPPEANCTDPEPVPPMIL------PPSPGSPVGPASPIL---------MEPLPPQC 1024

Query: 695  YKTLPH-VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLD--GLVNGAASSAGIPEP 751
               L H + P+  PP +  +PP +    P P++P     G+ D   L          PE 
Sbjct: 1025 SPLLQHSLVPQNSPP-SQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPEC 1083

Query: 752  PRLQGRG--------GELFAKRQSRA-----------DRYVVEGTPGPGLGPRPRSPSPT 792
            P L+           G+L     S A           D   ++G   PG  P    P  T
Sbjct: 1084 PALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQP---EPGQT 1140

Query: 793  P-SLPPSWKYSPNIRAPPPIA-YNPLLSPFFPQAARTL----PKAQSQGPRA----TPKQ 842
            P SL    K SP +  P  +A   P+    +P+  +T     P  + + PRA    TP  
Sbjct: 1141 PGSLASELKGSPVLLDPEELAPVTPM--EVYPECKQTAGQGSPCEEQEEPRAPVAPTPPT 1198

Query: 843  GIKA 846
             IK+
Sbjct: 1199 LIKS 1202



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 112/469 (23%), Positives = 150/469 (31%), Gaps = 109/469 (23%)

Query: 423  PRAQSAPPEAAVLPPSPLPAPVASPRPF-----QPGGGAP----------------TPAP 461
            PR  +APP     PP P P    +  P      +PG G P                TP P
Sbjct: 2187 PRFPTAPP---TYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDP 2243

Query: 462  SIFNRS------ARPFTPGLQGQRPTTTSVIFRPLAPKRA-----NDSLGGLSPA-PPPF 509
             +  R       A P +PG+ G + +   +   P    R       + LG  SP+  PP 
Sbjct: 2244 FLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPN 2303

Query: 510  LSSQGPTPLPSFTSGVPSHAP-VSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP 568
            L         +   G+    P V  +P TPR+S     +  L +     P     AP PP
Sbjct: 2304 LGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPP 2363

Query: 569  APPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEAR 628
            + P      S    +   PL P  RP+ P P      PP +     S P +R        
Sbjct: 2364 SHPDIFRPGSYTDPYAQPPLTP--RPQPPPPESCCALPPRSLP---SDPFSRV------- 2411

Query: 629  RRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQ 688
                      P   ++++S    L          PR   AE      A         F  
Sbjct: 2412 ----------PASPQSQSSSQSPL---------TPRPLSAE------AFCPSPVTPRFQS 2446

Query: 689  PVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGI 748
            P             P + PP  P++  P  P   PP  P+PP      G +   +  AG 
Sbjct: 2447 P------------DPYSRPPSRPQSRDPFAPLHKPP-RPQPPEVAFKAGSLAHTSLGAGG 2493

Query: 749  PEPPRLQGRGGELFAKRQSRADRYVVE--------GTPGP-------GLG-PRPRSPSPT 792
                   G  GEL AK  S      V         GTP P        +G P  + P P 
Sbjct: 2494 FPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQ 2553

Query: 793  PSLPP------SWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQG 835
            P LPP       +   P +  P    Y      F P  +   P + S G
Sbjct: 2554 PGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTG 2602



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 163/673 (24%), Positives = 231/673 (34%), Gaps = 122/673 (18%)

Query: 122  PLQPGSLRSPPDSEA---YYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLS 178
            P QPG+L SPP + A   + G   + A    + +   +P    P    P    P E++L 
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKP----PAGSVPGPDSPGELFLK 2162

Query: 179  DSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP--PPAEALLLPHGPLRPGPHLIPMVG 236
              P  PA      PSQ D    +P++     L+P  P A     P+      P   PM+G
Sbjct: 2163 LPPQVPAQV----PSQ-DPFGLAPAYP----LEPRFPTAPPTYPPYPSPTGAPAQPPMLG 2213

Query: 237  PVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVL 296
                P A      +T      + Q   S  +  +K    +C ++ +L      P S GV 
Sbjct: 2214 ASSRPGAGQPGEFHTTPPGTPRHQ--PSTPDPFLKP---RCPSLDNLAV----PESPGV- 2263

Query: 297  MFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPY 356
                                 G  +E     PP  ES    E   +    ++ S +  P 
Sbjct: 2264 -------------------GGGKASEPLLSPPPFGESRKALEVKKEELGASSPS-YGPPN 2303

Query: 357  LDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNG 416
            L       G   S   G+ LGG         ++L      +A   T   ++VEP +   G
Sbjct: 2304 L-------GFVDSPSSGTHLGG---------LELKTPDVFKAPL-TPRASQVEPQSPGLG 2346

Query: 417  EGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGA-PTPAPSIFNRSARPFTPGL 475
               Q PP AQ+             P+P + P  F+PG    P   P        P TP  
Sbjct: 2347 LRPQEPPPAQAL-----------APSPPSHPDIFRPGSYTDPYAQP--------PLTPRP 2387

Query: 476  QGQRPTTTSVIFRPLAPKRA--NDSLGGLSPAPPPFLSSQGP-TPLPSFTSGVPSHAPVS 532
            Q   P +   +     P R+  +D    +  +P    SSQ P TP P       S     
Sbjct: 2388 QPPPPESCCAL-----PPRSLPSDPFSRVPASPQSQSSSQSPLTPRPL------SAEAFC 2436

Query: 533  GSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMT-STASIFLSAPLRPS 591
             SP TPR   P   +     P    P  P   P  P PP  A    S A   L A   P+
Sbjct: 2437 PSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPA 2496

Query: 592  ARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS-PNP 650
            A P  PA    A  P       +  P     +   +  R T  Q    G+   K   P P
Sbjct: 2497 ALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAV--GEPSLKPPVPQP 2554

Query: 651  ELLSLVQNLDEKPRAGGAESGPEEDALSLG-AEACNFMQPVGARSYKTLPHVTPKTPPPM 709
             L          P    +  GP     +LG  ++ N+    G       P  +P  P   
Sbjct: 2555 GL--------PPPHGINSHFGP---GPTLGKPQSTNYTVATG----NFHPSGSPLGPSSG 2599

Query: 710  APKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRA 769
            +      ++P  PP V P P   G L  L +GA+  +GI  P   +   G       + A
Sbjct: 2600 STGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATA 2659

Query: 770  DRYVVEGTPGPGL 782
            +   + GT  PG+
Sbjct: 2660 E---LPGTQDPGM 2669



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 137/553 (24%), Positives = 187/553 (33%), Gaps = 100/553 (18%)

Query: 435  LPPSP----LPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSV--IFR 488
            +PP P     P P A+P  F    G+PT  P+  + SA  F     G  P   S   +F 
Sbjct: 2106 IPPQPGALGSPPPAAAPTIFI---GSPT-TPAGLSTSADGFLKPPAGSVPGPDSPGELFL 2161

Query: 489  PLAPKRA----NDSLGGLSPAPP--PFLSSQGPT--PLPSFTSGVPSHAPVSGSPSTPRS 540
             L P+      +    GL+PA P  P   +  PT  P PS T G P+  P+ G+ S P +
Sbjct: 2162 KLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPT-GAPAQPPMLGASSRPGA 2220

Query: 541  SGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPG 600
              P       +   P  P      P+P   P   ++ + A             PE+P  G
Sbjct: 2221 GQP----GEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAV------------PESPGVG 2264

Query: 601  PGAP-----EPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSL 655
             G        PP   E R ++   +  +   +   G     F        +    EL + 
Sbjct: 2265 GGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTP 2324

Query: 656  -VQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTP 714
             V      PRA   E  P+   L L  +     +P  A++    P   P    P +   P
Sbjct: 2325 DVFKAPLTPRASQVE--PQSPGLGLRPQ-----EPPPAQALAPSPPSHPDIFRPGSYTDP 2377

Query: 715  PPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVV 774
                P TP P  P P S   L      +   + +P  P+ Q         R   A+ +  
Sbjct: 2378 YAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAF-- 2435

Query: 775  EGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQ 834
               P P + PR +SP P  S PPS    P  R P    + PL  P  PQ      KA S 
Sbjct: 2436 --CPSP-VTPRFQSPDPY-SRPPS---RPQSRDP----FAPLHKPPRPQPPEVAFKAGSL 2484

Query: 835  GPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPA 894
               +    G  A             A     +VP    P    SP T          TP+
Sbjct: 2485 AHTSLGAGGFPA-------ALPAGPAGELHAKVPSGQPPNFVRSPGTGAF-----VGTPS 2532

Query: 895  PQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGA---------S 945
            P     P A           + EP  +      PVP P  PP  P G+ +          
Sbjct: 2533 PMRFTFPQA-----------VGEPSLK-----PPVPQPGLPP--PHGINSHFGPGPTLGK 2574

Query: 946  PSSCGFQVARPRF 958
            P S  + VA   F
Sbjct: 2575 PQSTNYTVATGNF 2587



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 183/815 (22%), Positives = 276/815 (33%), Gaps = 118/815 (14%)

Query: 100  ELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPAT---QEKPRR 156
            +LQ L     L         P   +PG+  SP               GP T   QE    
Sbjct: 4221 QLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAG 4280

Query: 157  PRRRGPTR-PTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
            PR +GP R P PPGA      L      P P+ P  P +  S++ SPS +     Q PP 
Sbjct: 4281 PRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKR-PSQLPSPSSQLPTEAQLPPT 4339

Query: 216  EALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKA--------KQAKLQRAE--SL 265
                 P  P   GP L P  G V  P A  L  T   K           A+ Q+ E  SL
Sbjct: 4340 H----PGTPKPQGPTLEPPPGRV-SPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSL 4394

Query: 266  QEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEED 325
                + +   +    AS L+    P  +   +  +  +R                  E  
Sbjct: 4395 VPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREAN--------------GEPI 4440

Query: 326  GVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQL-SEVS 384
            G P TS   L     S+A  L  Q    +  + +    +  R SEG  + + G + S+++
Sbjct: 4441 GAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQL----STGRGSEGLRAEINGHIDSKLA 4496

Query: 385  GRGVQLFEQQRQRADSS-----TQELARVEPAA---------MLNGEGLQSPPRAQSAPP 430
            G   +L      + D++     T +  RV+ A+         +   +G+++         
Sbjct: 4497 GLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLK 4556

Query: 431  EAAVLPPSPLPAPVASPRPFQP-GGGAPTPAPS----IFNRSARPFTPGLQGQRPTTTSV 485
            +   L P   PA  A+   F P G G P    S     F   A P  P    Q  T  ++
Sbjct: 4557 QELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNL 4616

Query: 486  IFRPLAPKRANDSLGGLSPAPPPFLSSQ---GPTPLPSFTSGVPSHAPVSGSPSTPRSSG 542
               P  P         L P PPP +  +   G TP           A    S    R + 
Sbjct: 4617 SNPPTPP-------SSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTS 4669

Query: 543  PVTATSSL-YIPAP----SRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAP 597
             V +   L  +P P    +  V      +  +P S    +S  SI           P  P
Sbjct: 4670 EVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESIL------GEEAPRFP 4723

Query: 598  APGPGAPEPPSAREQRI--SVPAARTGILQEARRRGTRKQMFRPGK------EETKNSPN 649
              G G  E        +   +P A   +  + +  G    +  PGK      E+ K S  
Sbjct: 4724 HLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGA-LGLEVPGKLPVTTWEKGKGSEV 4782

Query: 650  PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
              +L+ V     K   G   +  E  ++ +   +   + P       T P       P  
Sbjct: 4783 SVMLT-VSAAAAKNLNGVMVAVAELLSMKI-PNSYEVLFPESPARAGTEPKKGEAEGPGG 4840

Query: 710  APKTPPPMTPKTPP-------PVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELF 762
              K     +P T P        V P    +  LD +++     +  PEPP         +
Sbjct: 4841 KEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLD-ILSLLKQESPAPEPPTQHS-----Y 4894

Query: 763  AKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAP-PPIAYNPLLSPF- 820
                S  D   +   P     P P   +P+P+ PP+    P +  P  P+A  P+ SP  
Sbjct: 4895 TYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPT---EPLVELPTEPLAEPPVPSPLP 4951

Query: 821  ---FPQAARTLPKAQ-------SQGPRATPKQGIK 845
                P++AR  P+A+       S+ PR    +G++
Sbjct: 4952 LASSPESARPKPRARPPEEGEDSRPPRLKKWKGVR 4986



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 54/195 (27%), Positives = 75/195 (38%), Gaps = 48/195 (24%)

Query: 90  EGPVQSPSPHELQVLSPL--SPLSPEP---------------------PGAPVPQ----- 121
           E  +++P   E+ +L P   SPLSP P                     P +P+P+     
Sbjct: 427 EPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLS 486

Query: 122 -PLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRP---TPPGAPPDEVYL 177
            PL+   L  PP+        +S    P  +E P  P    P  P   TP   PP+   L
Sbjct: 487 RPLEESPLSPPPEESPLSPPPESSPFSP-LEESPLSPPEESPPSPALETPLSPPPEASPL 545

Query: 178 S----DSPAEPAP-TIPGPPSQGDSRVSSPSWE-------DGAALQPPPAEALLLP---H 222
           S    +SP  P P  +P  P    SR+S P  E       + + + PPP  + L P    
Sbjct: 546 SPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEE 605

Query: 223 GPLRPGPHLIPMVGP 237
            PL P P   P+  P
Sbjct: 606 SPLSPPPEESPLSPP 620



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 49/173 (28%), Positives = 64/173 (36%), Gaps = 25/173 (14%)

Query: 82  LTVQRLADEGPVQSPS-------PHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDS 134
           L + R  +E P+  P        P E    SPL      PP    P P     L  PP++
Sbjct: 483 LHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEA 542

Query: 135 EAYYGETDSDADGPATQEKPRRP-----RRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIP 189
                  +     P  +E P  P     R   P   +P   PP+E     SP  P P   
Sbjct: 543 SPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEE-----SPMSPPPEAS 597

Query: 190 G--PPSQGDSRVSSPSWEDGAALQPPPAEALLLP---HGPLRPGPHLIPMVGP 237
              PP + +S +S P  E  + L PPP  + L P     P+ P P   PM  P
Sbjct: 598 RLFPPFE-ESPLSPPPEE--SPLSPPPEASRLSPPPEDSPMSPPPEESPMSPP 647



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 161/721 (22%), Positives = 247/721 (34%), Gaps = 135/721 (18%)

Query: 90   EGPVQSPSPHELQVLSP-LSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGP 148
            +GP + P+P       P L P+ P PP +   +P +P  L SP        +  ++A  P
Sbjct: 4284 QGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPS------SQLPTEAQLP 4337

Query: 149  ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208
             T   P  P+ +GPT   PPG       +S + A+ A T+    S+G      P   D  
Sbjct: 4338 PTH--PGTPKPQGPTLEPPPGR------VSPAAAQLADTL---FSKGLGPWDPP---DNL 4383

Query: 209  ALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEK 268
            A    P ++ L+P        HL  + G V  P A  L+     + +   L  A+S++ +
Sbjct: 4384 AETQKPEQSSLVP-------GHLDQVNGQVV-PEASQLSIKQEPREEPCAL-GAQSVKRE 4434

Query: 269  SIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVP 328
            +  E      T   LL A P   +  +L+  ++  RAK   L     + G G+E   G+ 
Sbjct: 4435 ANGEPIGAPGTSNHLLLAGPRSEAGHLLL--QKLLRAKNVQL-----STGRGSE---GLR 4484

Query: 329  PTSESELDEE-AFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRG 387
                  +D + A  + +     S+ +       L     R  +     +  +       G
Sbjct: 4485 AEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDG 4544

Query: 388  VQLFEQQRQRADSSTQELARVEPAAMLNGE-----GLQSPPRAQSAPPEA---AVLPPSP 439
            V+  E   ++       L   EPA   N       G   P   QS    A     LP  P
Sbjct: 4545 VRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGP 4604

Query: 440  ------LPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQ-GQRPTTTSV------I 486
                  L     S  P  P    PTP PS+  +     TP  + G+ P   +        
Sbjct: 4605 DYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERA 4664

Query: 487  FRPLAPKRANDSLGGLSPAPP----PFLSSQGPTPLPSFTSGVPSHAPVS---------- 532
             R  +  ++ D L  L P PP      +  +      S  S VP+ +P S          
Sbjct: 4665 LRDTSEVKSLDLLAAL-PTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFP 4723

Query: 533  --GS--------------PSTPRSSGPVTATSSLY----IPAPSR-PVT-----PGGAPE 566
              GS              P  PR+S PV   +  Y    +  P + PVT      G    
Sbjct: 4724 HLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVS 4783

Query: 567  PPAPPSAAAMTSTASIFLSAPLRPSAR---------PEAPA-----PGPGAPEPPSAREQ 612
                 SAAA  +   + ++     S +         PE+PA     P  G  E P  +E+
Sbjct: 4784 VMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEK 4843

Query: 613  RISVPAARTGILQEARRRGTRKQMFRPG--KEETKNSPNPELLSLVQNLDEKPRAGGAES 670
             +   +  TG                P   K+     P   L S +  L    +   A  
Sbjct: 4844 GLEGKSPDTG----------------PDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPE 4887

Query: 671  GPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPP 730
             P + + +      +  Q       +  P  +P  P P +P T P +   T P   P  P
Sbjct: 4888 PPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVP 4947

Query: 731  S 731
            S
Sbjct: 4948 S 4948



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 51/174 (29%), Positives = 64/174 (36%), Gaps = 32/174 (18%)

Query: 91   GPVQSPSPHELQVLSPLSPLSP-----------EPPGAPVPQPLQPGS--LRSPPDSEAY 137
            G + SP P     +   SP +P           +PP   VP P  PG   L+ PP   A 
Sbjct: 2111 GALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQ 2170

Query: 138  YGETDSDADGPATQEKPRRPRR--RGPTRPTPPGAPPDEVYLSDS-------PAEPAPTI 188
                D     PA   +PR P      P  P+P GAP     L  S       P E   T 
Sbjct: 2171 VPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTP 2230

Query: 189  PGPPSQGDSRVSSPSWEDGAALQP--PPAEALLLPHGP-LRPGPHLIPMVGPVP 239
            PG P         PS  D   L+P  P  + L +P  P +  G    P++ P P
Sbjct: 2231 PGTPRH------QPSTPD-PFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPP 2277



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 130/597 (21%), Positives = 178/597 (29%), Gaps = 125/597 (20%)

Query: 94   QSPSPHELQVLSPLSPLSPE-------------PPGAPVPQP--------LQPGSLRSPP 132
            Q P P   Q L+P  P  P+             PP  P PQP        L P SL S P
Sbjct: 2350 QEPPP--AQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDP 2407

Query: 133  DSEAYYG-ETDSDADGPATQE---------KPRRPRRRGPTRPTPPGAPPDEVYLSDSPA 182
             S      ++ S +  P T            P  PR + P   + P + P     S  P 
Sbjct: 2408 FSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQ----SRDPF 2463

Query: 183  EPA--PTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPH 240
             P   P  P PP       S      GA   P       LP GP       +P  G  P+
Sbjct: 2464 APLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAA-----LPAGPAGELHAKVPS-GQPPN 2517

Query: 241  PVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKK 300
             V    T  +       +    +++ E S+K    +           P PH  G+     
Sbjct: 2518 FVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQ--------PGLPPPH--GINSHFG 2567

Query: 301  RRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLT----NQSDWDSPY 356
                  K    ++  A G        + P+S S  +    S  R  +       D   PY
Sbjct: 2568 PGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPY 2627

Query: 357  LDMELARAGSRAS-----EGQGSGLGGQLSE----------VSGRGVQLFEQQRQRA--- 398
            L    ++     S     E  G+G+G  L+           +SG      E+QRQR    
Sbjct: 2628 LSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLR 2687

Query: 399  -----DSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAV------------------- 434
                     +   R E        G   PP +  A P +                     
Sbjct: 2688 ELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSS 2747

Query: 435  ---LPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLA 491
               LPPS L  P+  P  F        P P      A P +  +  ++    S  F   A
Sbjct: 2748 LVGLPPSKLSGPILGPGSFPSDDRLSRPPP-----PATPSSMDVNSRQLVGGSQAFYQRA 2802

Query: 492  PKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSS-GPVTATSSL 550
            P   +     L          Q  T   S    + +  P +  P   R + G   A  S 
Sbjct: 2803 PYPGSLP---LQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGIST 2859

Query: 551  YIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPP 607
             +P P  PV     P P  P     +       +   L P      P PG G P+ P
Sbjct: 2860 RLPGPGEPV-----PGPAGPAQFIELRHN----VQKGLGPGG---TPFPGQGPPQRP 2904



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 106/461 (22%), Positives = 157/461 (34%), Gaps = 83/461 (18%)

Query: 379  QLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAP----PEAAV 434
            Q  ++  +  QL +QQ+Q+     Q+  + +   +     L SP + Q       P    
Sbjct: 3944 QQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPA 4003

Query: 435  LPPSPLPAPVA-SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPK 493
             P     +P A  P     G    T  P++ + +    +    G     T+       P 
Sbjct: 4004 KPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063

Query: 494  RANDSLGG------LSPAPPPFLSS---QGPTPLPS---------FTSGVPSHAPVSGSP 535
                SL G      + P P P  SS   Q P  LP           T+G  SH  +    
Sbjct: 4064 EVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGS 4123

Query: 536  STPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPE 595
            S+  SS P      L  P+ S    PG   +    P            L  P++ +  P+
Sbjct: 4124 SSEASSVP----HLLAQPSVSLGDQPGSMTQNLLGPQQP--------MLERPMQNNTGPQ 4171

Query: 596  APAPGP---------GAPEPPSAREQRISV-------PAAR----------TGILQEARR 629
             P PGP         G    P+  + R  +       P  R            +L + + 
Sbjct: 4172 PPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQL 4231

Query: 630  RGTRKQMFRPGKEE--TKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM 687
            + ++     P  +E  T+ SP   LL     L   P   G ++GP ++   LGA      
Sbjct: 4232 QQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFP---GPQTGPLQE---LGAGP---- 4281

Query: 688  QPVGARSYKTLPHVTPKTPPPMAP--KTPPPMTPKTP--PPVAPKPPSRGLLDGLVNGAA 743
            +P G       P     T P + P   TPPP +P+ P  P   P P S+     L   A 
Sbjct: 4282 RPQGPPRLPAPPGAL-STGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQ-----LPTEAQ 4335

Query: 744  SSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGP 784
                 P  P+ QG   E    R S A   + +     GLGP
Sbjct: 4336 LPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGP 4376



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 5/64 (7%)

Query: 886  EIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWR--TE-LASAPVPSPAPPPEAPRGL 942
            ++R+ S P P+  + P  P+ LAP  A+   EP+    TE LA  PVPSP P   +P   
Sbjct: 4902 DVRQLSAPPPEEPSPP--PSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESA 4959

Query: 943  GASP 946
               P
Sbjct: 4960 RPKP 4963



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 37/137 (27%), Positives = 45/137 (32%), Gaps = 29/137 (21%)

Query: 86   RLADEGPVQSPS--PHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDS 143
            +L  + P Q PS  P  L    PL P  P  P    P P   G+   PP      G +  
Sbjct: 2162 KLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPP----MLGASSR 2217

Query: 144  DADGPATQEKPRRPRRRGPTRPTPPGAP------PDEVYLSDSPAEPAPTIPGPPSQGDS 197
               G           + G    TPPG P      PD       P+     +P  P  G  
Sbjct: 2218 PGAG-----------QPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGG 2266

Query: 198  RVSSPSWEDGAALQPPP 214
            + S P       L PPP
Sbjct: 2267 KASEP------LLSPPP 2277



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 81/347 (23%), Positives = 106/347 (30%), Gaps = 48/347 (13%)

Query: 359  MELARAGSRASEGQ-GSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAA----M 413
            + L       S GQ GSG   + S V     Q       +  S TQ L   +       M
Sbjct: 4105 VSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPM 4164

Query: 414  LNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTP 473
             N  G Q PP+          LP   +   V   R    G  A  P     +   +    
Sbjct: 4165 QNNTGPQ-PPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQ 4223

Query: 474  GLQGQRPTTTSVIFRPLAPKRA----NDSLGGLSPAPPPFLSSQGPT--PLPSFTSGVPS 527
             L  QR    S   R   P +        L GL    P      GP   PL    +G   
Sbjct: 4224 ALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRP 4283

Query: 528  HAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAP 587
              P       PR   P  A S+  +  P  P  P  +P+ P  PS     S+        
Sbjct: 4284 QGP-------PRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSS-------- 4328

Query: 588  LRPSARPEAPAPGPGAP-------EPPSAREQRISVPAARTGILQE----------ARRR 630
             +     + P   PG P       EPP  R    +   A T   +           A  +
Sbjct: 4329 -QLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQ 4387

Query: 631  GTRKQMFRPGKEETKNS---PNPELLSLVQNLDEKPRAGGAESGPEE 674
               +    PG  +  N    P    LS+ Q   E+P A GA+S   E
Sbjct: 4388 KPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKRE 4434


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 208/879 (23%), Positives = 292/879 (33%), Gaps = 177/879 (20%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQP-LQP---GSLRSPPDSEAYYGETDSDADG 147
            P  +P+ +   +  P S +   PPGAP P P L P   G + S P      G   S   G
Sbjct: 187  PSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGG 246

Query: 148  P--ATQEKP-------------RRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPP 192
            P    Q  P               P  + PT P   G  P     ++ P    P +P PP
Sbjct: 247  PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFP-HVTPNLPPPP 305

Query: 193  SQGDSRVSSPSWEDGAALQPPPAEALLLPH------GPLRPGPHLIPMVGPVPHPV---- 242
            +      +S S   G   QP P   L  PH      G L PGP   P + P PH +    
Sbjct: 306  ALRPLNNASAS-PPGLGAQPLPGH-LPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363

Query: 243  ----AEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF 298
                A  +   Y+  +  +    + S    S        + + S   + P P S  V   
Sbjct: 364  SSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV--- 420

Query: 299  KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 358
                 +  KYT  S  +     A    G PP              R L N +    P+  
Sbjct: 421  ---SNQPPKYTQPSLPSQ----AVWSQGPPPPPPY---------GRLLANSNAHPGPFPP 464

Query: 359  MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 418
               A++ +            Q  +   +  Q  +QQ+Q   +S        P  +  G  
Sbjct: 465  STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSS 524

Query: 419  LQSPPRAQSA--------PPEAAVLPP----------SPLPAPVAS-------------- 446
              + P A S         PP  A LPP           P   PV+S              
Sbjct: 525  HHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYP 584

Query: 447  ---PRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP-------KRAN 496
               P P Q   GAP P P +   +    T         ++   ++  +P       KRA 
Sbjct: 585  CSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA- 643

Query: 497  DSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPS 556
             S G    A PP      P   PSF +G P     +  P+ P +  P + T     P P 
Sbjct: 644  PSPGAYKTATPPGYKPGSP---PSFRTGTPPGYRGTSPPAGPGTFKPGSPTVG---PGPL 697

Query: 557  RPVTPGGAPEPPAPPSAAAM--TSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRI 614
             P  P G P  P PP+A A     +A+     P      PE+P P   +P PP    + +
Sbjct: 698  PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPP---PKVV 754

Query: 615  SVP--AARTGILQEARRRG----TRKQMFRPGKEETK-NSPNPELLSLVQN------LDE 661
             VP  A+++    +   RG     R  ++    E +K      +L+  V+        +E
Sbjct: 755  DVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREE 814

Query: 662  KPRAGGAESGPE---------EDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK 712
            K R    E   E         E ++ L  E      PV   S   +PH  P  P      
Sbjct: 815  KEREREREREKEREREKERELERSVKLAQEG---RAPVECPSLGPVPHRPPFEPGSAVAT 871

Query: 713  TPPPMTPKTPP---------PVAPKPPSR--------GLLDGLVNGAASSAGIPEPPRLQ 755
             PP + P TP          P    P +R        G +D  + G    A     P  +
Sbjct: 872  VPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAR 931

Query: 756  GRGGELFAKRQSRADRY------------VVEGTPGPGLGPRPR------SPSPTPSLPP 797
             R  E  A+ +   DR              + G PGPGL P PR       P P P L P
Sbjct: 932  ERERE--ARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGP-PGLHP 988

Query: 798  SWKYSPNI----RAPPPIAYNPLLSPFFPQAARTLPKAQ 832
             + + P++    R    +A  P L P    A R   + Q
Sbjct: 989  -FPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQ 1026



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 169/738 (22%), Positives = 239/738 (32%), Gaps = 134/738 (18%)

Query: 299 KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 358
           +K RQ AKK  +            EE   P  ++    EE        TN         +
Sbjct: 48  EKSRQTAKKARV------------EEASTPKVNKQGRSEEISESESEETNAPK--KTKTE 93

Query: 359 MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 418
            EL R  S +     S  G  L++      +  +Q  +    S      VE  +  +   
Sbjct: 94  QELPRPQSPSD--LDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGL 151

Query: 419 LQSPPRAQSAPPEAAVLPPSPLPAPVASPRP----FQPGGGAPTPAPSIFNRSARPFTPG 474
            Q P R    PP   + PPSP P P ++PR     F+P    P+  P+ ++    P T  
Sbjct: 152 SQGPARPYHPPP---LFPPSPQP-PDSTPRQPEASFEPH---PSVTPTGYHAPMEPPTSR 204

Query: 475 LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGS 534
           +    P        P  P+      GG+   PP      G        +G   H P    
Sbjct: 205 MFQAPPGAP-----PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPP---- 255

Query: 535 PSTPRSSGPVTATSSLYIPAPSRPVTP-GGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR 593
           P+TP S   V+++ +   P    P TP GG   P APP A     T ++     LRP   
Sbjct: 256 PTTPIS---VSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN 312

Query: 594 PEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN-SPNPEL 652
             A  PG GA   P              G L      G       PG E+    +P+P  
Sbjct: 313 ASASPPGLGAQPLP--------------GHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS 358

Query: 653 LSLVQNLDEKPRAG---GAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
           L    +    P       + S     A S  + + +   P  A   + LP      PPP 
Sbjct: 359 LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPAS--QALPSYPHSFPPPT 416

Query: 710 A---PKTPPPMTPKTPPPVA------PKPPSRGLLDGLVN----------GAASSAGIP- 749
           +      PP  T  + P  A      P PP  G L    N          GA S+A  P 
Sbjct: 417 SLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPV 476

Query: 750 -----EPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGP-------------------- 784
                   + Q +  +   ++Q +   +   G P PG  P                    
Sbjct: 477 STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSL 536

Query: 785 ---RPRSPSPTPSLPPSWKYSPNIRAP--PPIAYNPLLSPFFPQAARTLPK-AQSQGPRA 838
              RP  P P    PP  + S +   P  PP++ +   S    Q +      + SQGP+ 
Sbjct: 537 GSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQG 596

Query: 839 TPKQG-------------IKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQ 885
            P                   +  +   P   KTA       PP P P    +P     +
Sbjct: 597 APYPFPPVPTVTTSSATLSTVIATVASSPAGYKTAS------PPGPPPYGKRAPSPGAYK 650

Query: 886 EIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP-PPEAPRGLGA 944
                + P  +P + P   T   P    T       T    +P   P P PP  P GL +
Sbjct: 651 TA---TPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707

Query: 945 SPSSCGFQVARPRFSATR 962
            P       + P  SAT+
Sbjct: 708 LPPPPAAPASGPPLSATQ 725



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 157/678 (23%), Positives = 209/678 (30%), Gaps = 127/678 (18%)

Query: 108 SPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR--P 165
           S LS  P     P PL P S + PPDS     E   +     T      P     +R   
Sbjct: 149 SGLSQGPARPYHPPPLFPPSPQ-PPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQ 207

Query: 166 TPPGAPPDEVYLSDSPAEPAPTIPGPP--SQGDSRVSSPSWEDGAALQPPPAEALLLPHG 223
            PPGAPP    L   P      + GPP   +G    SS    +G    PPP   + +   
Sbjct: 208 APPGAPPPHPQL--YPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSS 265

Query: 224 PLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASL 283
                P   P   PV                    L    +L+  +   A         L
Sbjct: 266 GASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPL 325

Query: 284 LTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDA 343
               P+PH+ G  M        K  TL          A     +PP S S          
Sbjct: 326 PGHLPSPHAMGQGMGGLPPGPEKGPTL----------APSPHSLPPASSSAPAPPMRFPY 375

Query: 344 RSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQ 403
            S ++ S           A A S +S    S      S+        F         S Q
Sbjct: 376 SSSSSSS-----------AAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS-LSVSNQ 423

Query: 404 ELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA-PS 462
                +P+        Q PP     PP   +L  S      A P PF P  GA + A P 
Sbjct: 424 PPKYTQPSLPSQAVWSQGPP---PPPPYGRLLANSN-----AHPGPFPPSTGAQSTAHPP 475

Query: 463 IFNRSARPFTPGLQGQR----------------PTTTSVIFRPLA--------PKRANDS 498
           +            Q Q+                P        PL         P   + S
Sbjct: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPS 535

Query: 499 LGGLSPAPPPFLSSQGPTPLP------SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           LG L P PP      GP  LP      S++   P+  PVS S ++  S    T+  S   
Sbjct: 536 LGSLRPYPP------GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSS----TSQGSYPC 585

Query: 553 PAPSRPVTPGGAPE--PPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAR 610
             PS    P GAP   PP P    +  + +++  +    P+    A  PGP    PP  +
Sbjct: 586 SHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGP----PPYGK 641

Query: 611 EQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAES 670
                  A   G  + A   G     ++PG   +  +  P            P AG    
Sbjct: 642 R------APSPGAYKTATPPG-----YKPGSPPSFRTGTPP-----GYRGTSPPAGPGTF 685

Query: 671 GPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPM------------- 717
            P    +  G      + P G     +LP      PPP AP + PP+             
Sbjct: 686 KPGSPTVGPGP-----LPPAGPSGLPSLP------PPPAAPASGPPLSATQIKQEPAEEY 734

Query: 718 -TPKTPPPVA--PKPPSR 732
            TP++P P A  P PP +
Sbjct: 735 ETPESPVPPARSPSPPPK 752



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 49/182 (26%), Positives = 69/182 (37%), Gaps = 29/182 (15%)

Query: 89  DEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGP 148
           ++GP  +PSPH       L P S   P  P+  P    S  S   S +    + S +  P
Sbjct: 347 EKGPTLAPSPHS------LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFP 400

Query: 149 ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208
           A+Q  P  P             PP  + +S+ P  P  T P  PSQ         W  G 
Sbjct: 401 ASQALPSYPH---------SFPPPTSLSVSNQP--PKYTQPSLPSQA-------VWSQGP 442

Query: 209 ALQPPPAEALLLPHGPLRPGPHLIPMVG--PVPHPVAEDLTTTYTQKAKQAKLQRAESLQ 266
              PPP    LL +    PGP   P  G     HP        + Q+ +Q + Q+ +  Q
Sbjct: 443 --PPPPPYGRLLANSNAHPGP-FPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQ 499

Query: 267 EK 268
           ++
Sbjct: 500 QQ 501



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 15/139 (10%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPA-TQEKP 154
           P P     L  L   S    G+  P+ +   + RS   S    G  ++D+D  +   + P
Sbjct: 97  PRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDN-RSTSPSIYSPGSVENDSDSSSGLSQGP 155

Query: 155 RRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPP 214
            RP    P  P  P  P       ++  EP P++            +P+    A ++PP 
Sbjct: 156 ARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSV------------TPTGYH-APMEPPT 202

Query: 215 AEALLLPHGPLRPGPHLIP 233
           +     P G   P P L P
Sbjct: 203 SRMFQAPPGAPPPHPQLYP 221


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 208/879 (23%), Positives = 292/879 (33%), Gaps = 177/879 (20%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQP-LQP---GSLRSPPDSEAYYGETDSDADG 147
            P  +P+ +   +  P S +   PPGAP P P L P   G + S P      G   S   G
Sbjct: 187  PSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGG 246

Query: 148  P--ATQEKP-------------RRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPP 192
            P    Q  P               P  + PT P   G  P     ++ P    P +P PP
Sbjct: 247  PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFP-HVTPNLPPPP 305

Query: 193  SQGDSRVSSPSWEDGAALQPPPAEALLLPH------GPLRPGPHLIPMVGPVPHPV---- 242
            +      +S S   G   QP P   L  PH      G L PGP   P + P PH +    
Sbjct: 306  ALRPLNNASAS-PPGLGAQPLPGH-LPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363

Query: 243  ----AEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF 298
                A  +   Y+  +  +    + S    S        + + S   + P P S  V   
Sbjct: 364  SSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV--- 420

Query: 299  KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 358
                 +  KYT  S  +     A    G PP              R L N +    P+  
Sbjct: 421  ---SNQPPKYTQPSLPSQ----AVWSQGPPPPPPY---------GRLLANSNAHPGPFPP 464

Query: 359  MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 418
               A++ +            Q  +   +  Q  +QQ+Q   +S        P  +  G  
Sbjct: 465  STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSS 524

Query: 419  LQSPPRAQSA--------PPEAAVLPP----------SPLPAPVAS-------------- 446
              + P A S         PP  A LPP           P   PV+S              
Sbjct: 525  HHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYP 584

Query: 447  ---PRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP-------KRAN 496
               P P Q   GAP P P +   +    T         ++   ++  +P       KRA 
Sbjct: 585  CSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA- 643

Query: 497  DSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPS 556
             S G    A PP      P   PSF +G P     +  P+ P +  P + T     P P 
Sbjct: 644  PSPGAYKTATPPGYKPGSP---PSFRTGTPPGYRGTSPPAGPGTFKPGSPTVG---PGPL 697

Query: 557  RPVTPGGAPEPPAPPSAAAM--TSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRI 614
             P  P G P  P PP+A A     +A+     P      PE+P P   +P PP    + +
Sbjct: 698  PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPP---PKVV 754

Query: 615  SVP--AARTGILQEARRRG----TRKQMFRPGKEETK-NSPNPELLSLVQN------LDE 661
             VP  A+++    +   RG     R  ++    E +K      +L+  V+        +E
Sbjct: 755  DVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREE 814

Query: 662  KPRAGGAESGPE---------EDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK 712
            K R    E   E         E ++ L  E      PV   S   +PH  P  P      
Sbjct: 815  KEREREREREKEREREKERELERSVKLAQEG---RAPVECPSLGPVPHRPPFEPGSAVAT 871

Query: 713  TPPPMTPKTPP---------PVAPKPPSR--------GLLDGLVNGAASSAGIPEPPRLQ 755
             PP + P TP          P    P +R        G +D  + G    A     P  +
Sbjct: 872  VPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAR 931

Query: 756  GRGGELFAKRQSRADRY------------VVEGTPGPGLGPRPR------SPSPTPSLPP 797
             R  E  A+ +   DR              + G PGPGL P PR       P P P L P
Sbjct: 932  ERERE--ARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGP-PGLHP 988

Query: 798  SWKYSPNI----RAPPPIAYNPLLSPFFPQAARTLPKAQ 832
             + + P++    R    +A  P L P    A R   + Q
Sbjct: 989  -FPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQ 1026



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 169/738 (22%), Positives = 239/738 (32%), Gaps = 134/738 (18%)

Query: 299 KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLD 358
           +K RQ AKK  +            EE   P  ++    EE        TN         +
Sbjct: 48  EKSRQTAKKARV------------EEASTPKVNKQGRSEEISESESEETNAPK--KTKTE 93

Query: 359 MELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEG 418
            EL R  S +     S  G  L++      +  +Q  +    S      VE  +  +   
Sbjct: 94  QELPRPQSPSD--LDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGL 151

Query: 419 LQSPPRAQSAPPEAAVLPPSPLPAPVASPRP----FQPGGGAPTPAPSIFNRSARPFTPG 474
            Q P R    PP   + PPSP P P ++PR     F+P    P+  P+ ++    P T  
Sbjct: 152 SQGPARPYHPPP---LFPPSPQP-PDSTPRQPEASFEPH---PSVTPTGYHAPMEPPTSR 204

Query: 475 LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGS 534
           +    P        P  P+      GG+   PP      G        +G   H P    
Sbjct: 205 MFQAPPGAP-----PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPP---- 255

Query: 535 PSTPRSSGPVTATSSLYIPAPSRPVTP-GGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR 593
           P+TP S   V+++ +   P    P TP GG   P APP A     T ++     LRP   
Sbjct: 256 PTTPIS---VSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN 312

Query: 594 PEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN-SPNPEL 652
             A  PG GA   P              G L      G       PG E+    +P+P  
Sbjct: 313 ASASPPGLGAQPLP--------------GHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS 358

Query: 653 LSLVQNLDEKPRAG---GAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
           L    +    P       + S     A S  + + +   P  A   + LP      PPP 
Sbjct: 359 LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPAS--QALPSYPHSFPPPT 416

Query: 710 A---PKTPPPMTPKTPPPVA------PKPPSRGLLDGLVN----------GAASSAGIP- 749
           +      PP  T  + P  A      P PP  G L    N          GA S+A  P 
Sbjct: 417 SLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPV 476

Query: 750 -----EPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGP-------------------- 784
                   + Q +  +   ++Q +   +   G P PG  P                    
Sbjct: 477 STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSL 536

Query: 785 ---RPRSPSPTPSLPPSWKYSPNIRAP--PPIAYNPLLSPFFPQAARTLPK-AQSQGPRA 838
              RP  P P    PP  + S +   P  PP++ +   S    Q +      + SQGP+ 
Sbjct: 537 GSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQG 596

Query: 839 TPKQG-------------IKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQ 885
            P                   +  +   P   KTA       PP P P    +P     +
Sbjct: 597 APYPFPPVPTVTTSSATLSTVIATVASSPAGYKTAS------PPGPPPYGKRAPSPGAYK 650

Query: 886 EIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP-PPEAPRGLGA 944
                + P  +P + P   T   P    T       T    +P   P P PP  P GL +
Sbjct: 651 TA---TPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707

Query: 945 SPSSCGFQVARPRFSATR 962
            P       + P  SAT+
Sbjct: 708 LPPPPAAPASGPPLSATQ 725



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 157/678 (23%), Positives = 209/678 (30%), Gaps = 127/678 (18%)

Query: 108 SPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR--P 165
           S LS  P     P PL P S + PPDS     E   +     T      P     +R   
Sbjct: 149 SGLSQGPARPYHPPPLFPPSPQ-PPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQ 207

Query: 166 TPPGAPPDEVYLSDSPAEPAPTIPGPP--SQGDSRVSSPSWEDGAALQPPPAEALLLPHG 223
            PPGAPP    L   P      + GPP   +G    SS    +G    PPP   + +   
Sbjct: 208 APPGAPPPHPQL--YPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSS 265

Query: 224 PLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASL 283
                P   P   PV                    L    +L+  +   A         L
Sbjct: 266 GASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPL 325

Query: 284 LTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDA 343
               P+PH+ G  M        K  TL          A     +PP S S          
Sbjct: 326 PGHLPSPHAMGQGMGGLPPGPEKGPTL----------APSPHSLPPASSSAPAPPMRFPY 375

Query: 344 RSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQ 403
            S ++ S           A A S +S    S      S+        F         S Q
Sbjct: 376 SSSSSSS-----------AAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS-LSVSNQ 423

Query: 404 ELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA-PS 462
                +P+        Q PP     PP   +L  S      A P PF P  GA + A P 
Sbjct: 424 PPKYTQPSLPSQAVWSQGPP---PPPPYGRLLANSN-----AHPGPFPPSTGAQSTAHPP 475

Query: 463 IFNRSARPFTPGLQGQR----------------PTTTSVIFRPLA--------PKRANDS 498
           +            Q Q+                P        PL         P   + S
Sbjct: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPS 535

Query: 499 LGGLSPAPPPFLSSQGPTPLP------SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYI 552
           LG L P PP      GP  LP      S++   P+  PVS S ++  S    T+  S   
Sbjct: 536 LGSLRPYPP------GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSS----TSQGSYPC 585

Query: 553 PAPSRPVTPGGAPE--PPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAR 610
             PS    P GAP   PP P    +  + +++  +    P+    A  PGP    PP  +
Sbjct: 586 SHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGP----PPYGK 641

Query: 611 EQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAES 670
                  A   G  + A   G     ++PG   +  +  P            P AG    
Sbjct: 642 R------APSPGAYKTATPPG-----YKPGSPPSFRTGTPP-----GYRGTSPPAGPGTF 685

Query: 671 GPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPM------------- 717
            P    +  G      + P G     +LP      PPP AP + PP+             
Sbjct: 686 KPGSPTVGPGP-----LPPAGPSGLPSLP------PPPAAPASGPPLSATQIKQEPAEEY 734

Query: 718 -TPKTPPPVA--PKPPSR 732
            TP++P P A  P PP +
Sbjct: 735 ETPESPVPPARSPSPPPK 752



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 49/182 (26%), Positives = 69/182 (37%), Gaps = 29/182 (15%)

Query: 89  DEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGP 148
           ++GP  +PSPH       L P S   P  P+  P    S  S   S +    + S +  P
Sbjct: 347 EKGPTLAPSPHS------LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFP 400

Query: 149 ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208
           A+Q  P  P             PP  + +S+ P  P  T P  PSQ         W  G 
Sbjct: 401 ASQALPSYPH---------SFPPPTSLSVSNQP--PKYTQPSLPSQA-------VWSQGP 442

Query: 209 ALQPPPAEALLLPHGPLRPGPHLIPMVG--PVPHPVAEDLTTTYTQKAKQAKLQRAESLQ 266
              PPP    LL +    PGP   P  G     HP        + Q+ +Q + Q+ +  Q
Sbjct: 443 --PPPPPYGRLLANSNAHPGP-FPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQ 499

Query: 267 EK 268
           ++
Sbjct: 500 QQ 501



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 15/139 (10%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPA-TQEKP 154
           P P     L  L   S    G+  P+ +   + RS   S    G  ++D+D  +   + P
Sbjct: 97  PRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDN-RSTSPSIYSPGSVENDSDSSSGLSQGP 155

Query: 155 RRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPP 214
            RP    P  P  P  P       ++  EP P++            +P+    A ++PP 
Sbjct: 156 ARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSV------------TPTGYH-APMEPPT 202

Query: 215 AEALLLPHGPLRPGPHLIP 233
           +     P G   P P L P
Sbjct: 203 SRMFQAPPGAPPPHPQLYP 221


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 120/431 (27%), Positives = 142/431 (32%), Gaps = 71/431 (16%)

Query: 409  EPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSA 468
            +P  +   E L  PP      P A + PP PLP     P P  PG G P P P     +A
Sbjct: 898  QPPPLQGTEMLPPPPPPL---PGAGIPPPPPLPGAGILPLPPLPGAGIPPPPP--LPGAA 952

Query: 469  RPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSH 528
             P  P L G       +   P  P       G   P PPP   +  P P P   +G+P  
Sbjct: 953  IPPPPPLPG-----AGIPLPPPLP-------GAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1000

Query: 529  APVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPL 588
             P+ G+   P    P        IP P  P+   G P PP  P A             P 
Sbjct: 1001 PPLPGAGIPPPPPLPGAG-----IPPPP-PLPGAGIPPPPPLPGAG--------IPPPPP 1046

Query: 589  RPSA--RPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN 646
             P A   P  P PG G P PP      I  P    G        G       PG      
Sbjct: 1047 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-------AGIPPPPPLPGAGIPPP 1099

Query: 647  SPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTP 706
             P P +      +   P   GA   P       G      +   G      LP V    P
Sbjct: 1100 PPLPGV-----GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154

Query: 707  PPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGL-VNGAASSAGIPEPPRLQGRGGELFAKR 765
            PP+     PP  P     + P PP  G+  G+         GIP PP L G G       
Sbjct: 1155 PPLPGAGIPPPPPLPGAGIPPPPPLPGV--GIPPPPPLPGVGIPPPPPLPGAG------- 1205

Query: 766  QSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQ-A 824
                   +    P PG+G     P+P P LPP     P    PPP        P  PQ  
Sbjct: 1206 -------IPPPPPLPGMG---IPPAPAPPLPP-----PGTGIPPPPLLPVSGPPLLPQVG 1250

Query: 825  ARTLPKAQSQG 835
            + TLP  Q  G
Sbjct: 1251 SSTLPTPQVCG 1261



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 137/514 (26%), Positives = 164/514 (31%), Gaps = 106/514 (20%)

Query: 437  PSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRAN 496
            PSP P P        PG G   P P        P  PG+      +T++   P  P    
Sbjct: 856  PSPPPLPCTESSSSMPGLGMVPPPP--------PPLPGMTVPTLPSTAI---PQPP---- 900

Query: 497  DSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPS 556
              L G    PPP      P PLP   +G+P   P+ G+   P    P        IP P 
Sbjct: 901  -PLQGTEMLPPP------PPPLPG--AGIPPPPPLPGAGILPLPPLPGAG-----IPPP- 945

Query: 557  RPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSA--RPEAPAPGPGAPEPPSAREQRI 614
             P  PG A  PP P         A I L  PL P A   P  P PG G P PP      I
Sbjct: 946  -PPLPGAAIPPPPP------LPGAGIPLPPPL-PGAGIPPPPPLPGAGIPPPPPLPGAGI 997

Query: 615  SVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEE 674
              P    G        G       PG       P P        +   P   GA   P  
Sbjct: 998  PPPPPLPG-------AGIPPPPPLPGAGIPPPPPLPG-----AGIPPPPPLPGAGIPPPP 1045

Query: 675  DALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGL 734
                 G      +   G      LP      PPP+     PP  P     + P PP  G+
Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV 1105

Query: 735  LDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPS 794
                        GIP PP L G G              +    P PG G  P  P P   
Sbjct: 1106 ------------GIPPPPPLPGAG--------------IPPPPPLPGAGIPPPPPLPGAG 1139

Query: 795  LPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQP 854
            +PP     P +  PPP    PL     P     LP A    P   P  GI         P
Sbjct: 1140 IPPP-PPLPRVGIPPP---PPLPGAGIPPPP-PLPGAGIPPPPPLPGVGIP-------PP 1187

Query: 855  YQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAP--TVLAPRAA 912
              L         +PP P    +G P    +  +     PAP     PL P  T + P   
Sbjct: 1188 PPLPGV-----GIPPPPPLPGAGIPPPPPLPGMGIPPAPAP-----PLPPPGTGIPPPPL 1237

Query: 913  TTLDEPIWRTELASAPVPSPAP----PPEAPRGL 942
              +  P    ++ S+ +P+P      PP  P GL
Sbjct: 1238 LPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGL 1271



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 133/528 (25%), Positives = 164/528 (31%), Gaps = 80/528 (15%)

Query: 454  GGAPTPAPSIFNRSARPFTPGLQ-GQRPTTTSVIFRPLAPKRANDSLGGLSPA------P 506
            GG  T  P        P  PG + G +    S I   ++P+R +  L    P       P
Sbjct: 752  GGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPP 811

Query: 507  PPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATS----SLYIPAP------- 555
            PP      P+ L S   G P   P     +  ++S   + +S    S  IP+P       
Sbjct: 812  PP------PSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865

Query: 556  SRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR-------PEAPAPGPGAPEPPS 608
            S    PG    PP PP    MT       + P  P  +       P  P PG G P PP 
Sbjct: 866  SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPP- 924

Query: 609  AREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGA 668
                   +P A    L      G       PG       P P        +   P   GA
Sbjct: 925  ------PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPG-----AGIPLPPPLPGA 973

Query: 669  ESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM--APKTPPPMTPKTPPPVA 726
               P       G      +   G      LP      PPP+  A   PPP  P    P  
Sbjct: 974  GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1033

Query: 727  PKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRP 786
            P  P  G+           AGIP PP L G G              +    P PG G  P
Sbjct: 1034 PPLPGAGIPP---PPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIPP 1087

Query: 787  RSPSPTPSLPPSWKYSPNIRAPPP-------IAYNPLLSPFFPQAARTLPKAQSQGPRAT 839
              P P   +PP     P +  PPP       I   P L          LP A    P   
Sbjct: 1088 PPPLPGAGIPPP-PPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1146

Query: 840  PKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQP-T 898
            P+ GI         P  L  A      +PP P    +G P    +  +     P P P  
Sbjct: 1147 PRVGIP-------PPPPLPGA-----GIPPPPPLPGAGIPPPPPLPGV---GIPPPPPLP 1191

Query: 899  AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASP 946
               + P    P A      P+    +  AP P P PPP    G G  P
Sbjct: 1192 GVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAP-PLPPP----GTGIPP 1234



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 43/135 (31%), Positives = 47/135 (34%), Gaps = 15/135 (11%)

Query: 408  VEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRS 467
            + P   L G G+  PP      P A + PP PLP     P P  PG G P P P     +
Sbjct: 1151 IPPPPPLPGAGIPPPPPL----PGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP--LPGA 1204

Query: 468  ARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPS 527
              P  P L G           PL P        G    PPP L   GP  LP   S    
Sbjct: 1205 GIPPPPPLPGMGIPPAPA--PPLPPP-------GTGIPPPPLLPVSGPPLLPQVGSSTLP 1255

Query: 528  HAPVSGSPSTPRSSG 542
               V G    P  SG
Sbjct: 1256 TPQVCGFLPPPLPSG 1270



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 48/156 (30%), Positives = 54/156 (34%), Gaps = 16/156 (10%)

Query: 96   PSPHELQVLSPLSPLSPEPPGA--PVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEK 153
            P P  LQ    L P  P  PGA  P P PL    +   P              G A    
Sbjct: 897  PQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956

Query: 154  PRRPRRRGPTRPTPPGA----PPDEVYLSDSPAEPAPT--IPGPPSQGDSRVSSPSWEDG 207
            P  P    P  P  PGA    PP        P  P P   IP PP    + +  P    G
Sbjct: 957  PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1016

Query: 208  AALQPPPAEALLLPHGPLRPGPHL----IPMVGPVP 239
            A + PPP     LP   + P P L    IP   P+P
Sbjct: 1017 AGIPPPPP----LPGAGIPPPPPLPGAGIPPPPPLP 1048



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 91/362 (25%), Positives = 115/362 (31%), Gaps = 65/362 (17%)

Query: 601  PGAPE-PPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLV--- 656
            PG P  PP A     +   +   ++   RR   +    +P +  ++  P P LL      
Sbjct: 764  PGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQG 823

Query: 657  QNLDEKPRAGGAE--SGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTP 714
            Q   + P +   E  +  E    S    +CN   P        LP     +  P     P
Sbjct: 824  QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSP------PPLPCTESSSSMPGLGMVP 877

Query: 715  PPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVV 774
            PP     PPP          L G+      S  IP+PP LQG    L           + 
Sbjct: 878  PP-----PPP----------LPGMTVPTLPSTAIPQPPPLQGT-EMLPPPPPPLPGAGIP 921

Query: 775  EGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQ 834
               P PG G  P  P P   +PP     P    PPP    PL     P     LP A   
Sbjct: 922  PPPPLPGAGILPLPPLPGAGIPPP-PPLPGAAIPPP---PPLPGAGIP-LPPPLPGAGIP 976

Query: 835  GPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPA 894
             P   P  GI         P  L  A      +PP P    +G P             P 
Sbjct: 977  PPPPLPGAGIP-------PPPPLPGA-----GIPPPPPLPGAGIP------------PPP 1012

Query: 895  PQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVA 954
            P P A  + P    P A      P     L  A +P P P P A  G+   P   G  + 
Sbjct: 1013 PLPGA-GIPPPPPLPGAGIPPPPP-----LPGAGIPPPPPLPGA--GIPPPPPLPGAGIP 1064

Query: 955  RP 956
             P
Sbjct: 1065 PP 1066



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 42/144 (29%), Positives = 51/144 (35%), Gaps = 21/144 (14%)

Query: 106  PLSPLSPEPP----GAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG 161
            P + + P PP    G P+P PL    +  PP              G      P  P    
Sbjct: 949  PGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1008

Query: 162  PTRPTPPGA--PPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALL 219
            P  P  PGA  PP        P  P   IP PP    + +  P    GA + PPP     
Sbjct: 1009 PPPPPLPGAGIPPP-------PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP---- 1057

Query: 220  LPHGPLRPGPHL----IPMVGPVP 239
            LP   + P P L    IP   P+P
Sbjct: 1058 LPGAGIPPPPPLPGAGIPPPPPLP 1081



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 42/150 (28%), Positives = 52/150 (34%), Gaps = 16/150 (10%)

Query: 106  PLSPLSPEPP----GAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG 161
            P + + P PP    G P P PL    +  PP              G      P  P    
Sbjct: 1114 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGI 1173

Query: 162  PTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALL-- 219
            P  P  PG     V +   P  P   IP PP    + +  P    G  + P PA  L   
Sbjct: 1174 PPPPPLPG-----VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPP 1228

Query: 220  ---LPHGPLRP--GPHLIPMVGPVPHPVAE 244
               +P  PL P  GP L+P VG    P  +
Sbjct: 1229 GTGIPPPPLLPVSGPPLLPQVGSSTLPTPQ 1258



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 43/140 (30%), Positives = 49/140 (35%), Gaps = 15/140 (10%)

Query: 109  PLSPEPPGA--PVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPT 166
            PL P  PGA  P P PL    +  PP              G      P  P    P  P 
Sbjct: 965  PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1024

Query: 167  PPGA--PPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA-EALLLPHG 223
             PGA  PP        P  P   IP PP    + +  P    GA + PPP      +P  
Sbjct: 1025 LPGAGIPPP-------PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077

Query: 224  PLRPGPHLIPMVGPVPHPVA 243
            P  PG  + P   P P P A
Sbjct: 1078 PPLPGAGIPP---PPPLPGA 1094



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 18/148 (12%)

Query: 106  PLSPLSPEPP----GAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG 161
            P + + P PP    G P P PL    +  PP              G      P  P    
Sbjct: 1026 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1085

Query: 162  PTRPTPPGA------PPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
            P  P  PGA      P   V +   P  P   IP PP    + +  P    GA + PPP 
Sbjct: 1086 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1145

Query: 216  EALLLPHGPLRPGPHL----IPMVGPVP 239
                LP   + P P L    IP   P+P
Sbjct: 1146 ----LPRVGIPPPPPLPGAGIPPPPPLP 1169



 Score = 37.4 bits (85), Expect = 0.069
 Identities = 70/268 (26%), Positives = 95/268 (35%), Gaps = 55/268 (20%)

Query: 500 GGLSPAPPPFLSSQGPTPLPSFT------SGVPSHAPVSGSPSTPRSSGPVTATSSLYIP 553
           G   PA PP   S  P             SG    AP  GSP T ++   ++        
Sbjct: 228 GAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAP--GSPDTEQALSALSDLPESLAA 285

Query: 554 AP---SRPVTPGGAP--EPPAPPSA--AAMTSTASIFLSAPLRPSARPEAPAPGPGAPEP 606
            P    +P +PGG P  E P+ P+A  AA  S +S     P        A AP  GA + 
Sbjct: 286 EPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDT 345

Query: 607 PSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG 666
               E+     A R                  PG+E       PE+       ++ P+  
Sbjct: 346 DEEGEEDAFEDAPRGS----------------PGEEWA-----PEV------GEDAPQRL 378

Query: 667 GAESGPEEDALSLGAEACNFMQPVGA---RSYKTLPHVTP-----KTPPPMAPKTPPPMT 718
           G E  PEE+A    A A   +    A   R +K  P +TP      T    +P   P  +
Sbjct: 379 GEE--PEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQS 436

Query: 719 PKTPPPVAPKPP---SRGLLDGLVNGAA 743
           P   P +  +P    SRG    L + AA
Sbjct: 437 PNQSPRIKRRPEPSLSRGSRTALASVAA 464



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 41/140 (29%), Positives = 48/140 (34%), Gaps = 19/140 (13%)

Query: 112 PEPPGAPVPQPLQ--PGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPG 169
           P PP  P  +     PG    PP      G T       A    P+ P  +G T   PP 
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAI---PQPPPLQG-TEMLPPP 911

Query: 170 APPDEVYLSDSPAEPAPTIPG------PPSQGDSRVSSPSWEDGAALQPPPAEALLLPHG 223
            PP    L  +   P P +PG      PP  G      P     A   PPP     +P  
Sbjct: 912 PPP----LPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967

Query: 224 PLRPGPHLIPMVGPVPHPVA 243
           P  PG  + P   P P P A
Sbjct: 968 PPLPGAGIPP---PPPLPGA 984



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 7/119 (5%)

Query: 127 SLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAP 186
           ++ SPP        +     G      P  P    PT P+     P  +  ++    P P
Sbjct: 854 NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP 913

Query: 187 TIPG------PPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239
            +PG      PP  G   +  P         PPP     +P  P  PG   IP+  P+P
Sbjct: 914 PLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAG-IPLPPPLP 971



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 22/72 (30%), Positives = 28/72 (38%), Gaps = 2/72 (2%)

Query: 406  ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFN 465
            A + P   L G G+   P     PP   + PP PL  PV+ P      G +  P P +  
Sbjct: 1204 AGIPPPPPLPGMGIPPAPAPPLPPPGTGI-PPPPL-LPVSGPPLLPQVGSSTLPTPQVCG 1261

Query: 466  RSARPFTPGLQG 477
                P   GL G
Sbjct: 1262 FLPPPLPSGLFG 1273


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 200/804 (24%), Positives = 279/804 (34%), Gaps = 147/804 (18%)

Query: 207 GAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQ 266
           GAA + P A A     G L P P   P   P   P A  +        ++   +RA  + 
Sbjct: 11  GAAARTPAARA----PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 267 EKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYT----LVSFGAAAGT--- 319
             +I E+  +     S  T++ NP S+     +  R    K T    + S G A+GT   
Sbjct: 67  GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 126

Query: 320 ----------GAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRAS 369
                      AEE       +E+       + AR  T+     +P      + A +R S
Sbjct: 127 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP------SPAMARRS 180

Query: 370 EGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQE-------LARVEPAAMLNGEGLQSP 422
              G+ +G      S R     E  R+   S+++         AR  P+A   G GLQ P
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA---GGGLQRP 237

Query: 423 PRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTT 482
                     A    S    P++SP    P       AP+     ++P   GLQ  RP  
Sbjct: 238 ----------ASRSLSSSATPLSSPARSGPSARGTPRAPA---HPSQPKPKGLQALRPPQ 284

Query: 483 TSVIFRPLAPKRANDSLGGLS-PAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSS 541
            +   +  AP     S   L+ P+P   L SQ P  LP+     P  + ++   +TP   
Sbjct: 285 VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPA----TPHSSSLTCQLATPLPL 340

Query: 542 GPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTS--------TASIFLSAPLRPSAR 593
            P         P+PS P +    P PPA P + A TS        T S   S PL P A 
Sbjct: 341 AP---------PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391

Query: 594 PEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELL 653
           P   AP P    PP   +   S PA+                   P    +  +PN   +
Sbjct: 392 PPPQAP-PALALPP--LQAPPSPPAS---------------PPLSPLATPSPQAPNALAV 433

Query: 654 SLVQ---NLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMA 710
            L+Q   +    P      S P    +S  A   +   P  A          P   PP  
Sbjct: 434 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA--------APPLQVPPSP 485

Query: 711 PKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRAD 770
           P +PP     TPPP AP P +   L        +   +  PP                  
Sbjct: 486 PASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP------------------ 527

Query: 771 RYVVEGTPGPGLGPRPRSP-SPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLP 829
              ++  P P      ++P SP+ SLP S   +P  +APP +A   L  P  P A+ TL 
Sbjct: 528 ---LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL- 583

Query: 830 KAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIAS---------GSPK 880
               Q PR  P  G    D     P +L  A+      PP+  P ++          S  
Sbjct: 584 ----QAPRRPPTPG---PDTSVSGP-RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA 635

Query: 881 TARVQEIRRF-STPAPQPTAEPLAPTVLAP-RAATTLDEPIWRTELASAP-VPSPAPPPE 937
           T+  +E+R + S P     A P     LA    A     P        AP  P P PP  
Sbjct: 636 TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 695

Query: 938 APRGLGASPSSCGFQVARPRFSAT 961
            P   G++   C         SAT
Sbjct: 696 GP---GSADGLCTIYETEGPESAT 716



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 197/781 (25%), Positives = 268/781 (34%), Gaps = 124/781 (15%)

Query: 110 LSPEPPGAP-VPQPLQPGSLRSPPDSEAYYGETDSD-ADGPATQEKPRRPRRRGPTRPTP 167
           L+P PPG+P  P P+ P +LR    + A   +  ++ A G      P    R GPTR   
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSA- 83

Query: 168 PGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRP 227
                       S   PA     PP+ G    + P+        P P  +     G  RP
Sbjct: 84  ----------GTSSRNPASR---PPASGRGERAPPA----KNTSPGPVSSPGRASGTTRP 126

Query: 228 GPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAA 287
           GP     +G     ++ + T     + K  +  +  +L   + ++            T+ 
Sbjct: 127 GP-----LGQKGLRISAEETVA---RGKATEAPKRSALSAGARRD------------TSG 166

Query: 288 PNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLT 347
           P P +    M ++ R             AAGT    E G+P  + S          R   
Sbjct: 167 PTPGTPSPAMARRSR-------------AAGT----EVGLPRPAPSARPRPPTEGPRKSV 209

Query: 348 NQSDWDSPYLDMELARAGSRASEGQGSGLGGQLS-EVSGRGVQLFEQQRQRADSSTQELA 406
           + +   S       AR    A    G GL    S  +S     L    R    +     A
Sbjct: 210 SSASEHSTTEPSPAARRRPSA----GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 407 RVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNR 466
              P+        Q  P+   A     V PP    AP   P    P     TP+PS   +
Sbjct: 266 PAHPS--------QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP---LATPSPSAALQ 314

Query: 467 SARPFTPGLQGQRPTTTSVIFR--PLAP--KRANDSLGGLSPAPPPFLSSQGPTPLPSFT 522
           S  P T        + T  +    PLAP    A  SL  L P+PP    SQ  T L S T
Sbjct: 315 SQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL-PSPPATPPSQATTSLGSPT 373

Query: 523 SGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP--EPPAPPSAAAMTSTA 580
               +H+ +   P +P ++ P  A  +L +P    P +P  +P   P A PS  A  + A
Sbjct: 374 LQA-THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 432

Query: 581 SIFLSAPLRPSARPEAPAP-GPGAPEP--PSAREQRISVPAARTGILQEARRRGTRKQMF 637
              L AP  P   P   AP  P A  P  PSA     + P+     LQ          M 
Sbjct: 433 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM- 491

Query: 638 RPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
            P       +P P     +Q     P+A  A + P   AL   +   +F          +
Sbjct: 492 SPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP--SPPASFPGQAPFSPSAS 549

Query: 698 LPHVTPKTPPPMAPKT-------PPPMTPKTPPPVAPKPPSRGLLDGLVNG----AASSA 746
           LP     TPPP AP          PP  P +P   AP+ P     D  V+G     A + 
Sbjct: 550 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP 609

Query: 747 GIPEPPRLQGR---GGELFAKRQSRADRYVVE--GTPGPGLGPRPRSPSPTPSL----PP 797
           G P PP         G   A   S A     E  G      G    SP P   L    P 
Sbjct: 610 GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA 669

Query: 798 SWKYSPNIRAPP---------PIAYNPLLSPFFPQAARTLPKAQSQGPR-ATPKQGIKAL 847
           +W   P   APP         P+ + P   P       T+   +++GP  ATP  G  AL
Sbjct: 670 AWSRGP---APPLAFRGAPGAPLPWPPATGPGSADGLCTI--YETEGPESATPAPG--AL 722

Query: 848 D 848
           D
Sbjct: 723 D 723



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 138/571 (24%), Positives = 196/571 (34%), Gaps = 97/571 (16%)

Query: 424 RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTT 483
           +   A   AA   P+     + +PRP     G+P P P        P TP          
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTPRP----PGSPRPPP--------PVTPAALRVLGAAG 51

Query: 484 SVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRS--S 541
           +V  +PLA +      GG+  A  P      P   P+ ++G  S  P S  P++ R   +
Sbjct: 52  AVGRKPLAERA-----GGIGGATIP---ESAPRAGPTRSAGTSSRNPASRPPASGRGERA 103

Query: 542 GPVTATSSLYIPAPSRP---VTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPS----ARP 594
            P   TS   + +P R      PG   +     SA    +       AP R +    AR 
Sbjct: 104 PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA-TEAPKRSALSAGARR 162

Query: 595 EAPAPGPGAPEPPSAREQR-----ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPN 649
           +   P PG P P  AR  R     + +P             G RK +     E +   P+
Sbjct: 163 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV-SSASEHSTTEPS 221

Query: 650 PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
           P           +P AGG    P   +LS  A   +     G  +       TP+ P   
Sbjct: 222 PA-------ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA-----RGTPRAPAHP 269

Query: 710 APKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEP-PRLQGRGGELFAKRQSR 768
           +   P  +    PP V   PP +     L   ++S    P P   LQ +           
Sbjct: 270 SQPKPKGLQALRPPQVT--PPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHS 327

Query: 769 ADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTL 828
           +       TP P L P      P+PS PPS +  P+  A PP      L     QA  + 
Sbjct: 328 SSLTCQLATPLP-LAP------PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSF 380

Query: 829 PKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTP------GPIASGSPKTA 882
             +    P ATP    +A   +   P Q           PP+P       P+A+ SP+  
Sbjct: 381 LPSPPLSPLATPPP--QAPPALALPPLQ----------APPSPPASPPLSPLATPSPQAP 428

Query: 883 RVQEIR----RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPV--------- 929
               +      FS P   P   P +P    P + +          LA+ P+         
Sbjct: 429 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 488

Query: 930 ----PSPAPPPEAPRGLGASPSSCGFQVARP 956
               PS  PPP+AP  L A P     Q+A+P
Sbjct: 489 PPMSPSATPPPQAPPPLAAPP----LQLAKP 515



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 46/160 (28%), Positives = 60/160 (37%), Gaps = 13/160 (8%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P  LQ L P     P    AP   PL    L +P  S A   ++ +    PAT     
Sbjct: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAAL--QSQAPPTLPATPHSSS 329

Query: 156 RPRRRG---PTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQP 212
              +     P  P  P APP    L   P+ PA     PPSQ  + + SP+ +   +  P
Sbjct: 330 LTCQLATPLPLAPPSPSAPPS---LQTLPSPPAT----PPSQATTSLGSPTLQATHSFLP 382

Query: 213 -PPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYT 251
            PP   L  P     P   L P+  P   P +  L+   T
Sbjct: 383 SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT 422



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 67/271 (24%), Positives = 93/271 (34%), Gaps = 33/271 (12%)

Query: 704 KTPPPMAPK--TP-PPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG-IPEPPRLQGRGG 759
           +TP   AP   TP PP +P+ PPPV P           V GAA + G  P   R  G GG
Sbjct: 15  RTPAARAPGLLTPRPPGSPRPPPPVTPAALR-------VLGAAGAVGRKPLAERAGGIGG 67

Query: 760 ELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSP 819
               +   RA      GT       RP +       PP+   SP           P+ SP
Sbjct: 68  ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP----------GPVSSP 117

Query: 820 FFPQAARTLPKAQSQGPRATPKQGI---KALDFMRHQPYQLKTAMFCFDEVPPTPGPIAS 876
                         +G R + ++ +   KA +  +                P TP P  +
Sbjct: 118 GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 177

Query: 877 GSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPP 936
              + A  +       P P P+A P  PT    ++ ++  E        + P P+    P
Sbjct: 178 RRSRAAGTE----VGLPRPAPSARPRPPTEGPRKSVSSASE-----HSTTEPSPAARRRP 228

Query: 937 EAPRGLGASPSSCGFQVARPRFSATRTGLQA 967
            A  GL    S      A P  S  R+G  A
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSA 259



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/124 (27%), Positives = 47/124 (37%), Gaps = 19/124 (15%)

Query: 106 PLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRP 165
           P+SP +  PP AP P    P  L  PP               PA    P +        P
Sbjct: 490 PMSPSATPPPQAPPPLAAPPLQLAKPPPQAP-----------PALATPPLQ------ALP 532

Query: 166 TPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPL 225
           +PP + P +   S S + P   +  PP Q    +++P  +      PP +  L  P  P 
Sbjct: 533 SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ--VPPSPPASPTLQAPRRPP 590

Query: 226 RPGP 229
            PGP
Sbjct: 591 TPGP 594



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 42/151 (27%), Positives = 57/151 (37%), Gaps = 19/151 (12%)

Query: 99  HELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPR 158
           H      PLSPL+  PP AP    L P  L++PP   A      S    P     P+ P 
Sbjct: 378 HSFLPSPPLSPLATPPPQAPPALALPP--LQAPPSPPA------SPPLSPLATPSPQAPN 429

Query: 159 RRG----PTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPP 214
                      +PP +PP +   S   + P      PPSQ    +++P       LQ PP
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP------PLQVPP 483

Query: 215 AEALLLPHGP-LRPGPHLIPMVGPVPHPVAE 244
           +     P  P   P P   P +   P  +A+
Sbjct: 484 SPPASPPMSPSATPPPQAPPPLAAPPLQLAK 514



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 101/463 (21%), Positives = 138/463 (29%), Gaps = 57/463 (12%)

Query: 92  PVQSPSPHE----LQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           P    +PH      Q+ +PL    P P   P  Q L       P  +    G     A  
Sbjct: 319 PTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 378

Query: 148 PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDG 207
                 P       P    PP APP    L+  P +  P+ P  P        SP     
Sbjct: 379 SFLPSPP-----LSPLATPPPQAPP---ALALPPLQAPPSPPASPPLSPLATPSP----- 425

Query: 208 AALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQE 267
              Q P A A+ L   P  P P   P+  P   P +  ++ + T  ++      A  LQ 
Sbjct: 426 ---QAPNALAVHLLQAPFSPPPS-PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481

Query: 268 KSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGV 327
                A       A+    AP P +   L   K   +A          A  T   +    
Sbjct: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--------PALATPPLQALPS 533

Query: 328 PPTS---ESELDEEAFSDARSLTNQSDWDSPYLDMELAR------AGSRASEGQGSGLGG 378
           PP S   ++     A      L        P L   L +      A       +     G
Sbjct: 534 PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG 593

Query: 379 QLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQS-PPRAQSAPPEAAVLPP 437
             + VSG  + L          S        P++ L+G  L      A S P E      
Sbjct: 594 PDTSVSGPRLTLALAPGPPPPPSR------SPSSTLSGPDLAGHSSSATSTPEELRGYDS 647

Query: 438 SPLPAPVASPRP------FQPGGGAPTPAPSIFNRSA----RPFTPGLQGQRPTTTSVIF 487
            P     ASP P        P   +  PAP +  R A     P+ P            I+
Sbjct: 648 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY 707

Query: 488 RPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAP 530
               P+ A  + G L P P P   + G        +G  S +P
Sbjct: 708 ETEGPESATPAPGALDPGPSP--GTSGGKAAAGAGAGASSRSP 748


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 217/913 (23%), Positives = 307/913 (33%), Gaps = 155/913 (16%)

Query: 111  SPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGA 170
            +P+PP  P P  ++   +  P   +   G T            PR P    P RP PPG 
Sbjct: 980  APDPPPRPKPVKMKVNRMLQPVPKQE--GRT------VVVVNNPRAPLGPVPVRP-PPG- 1029

Query: 171  PPDEVYLSDSPAEPAPTIPGPPSQ---GDSRVS-SPSWEDGAALQPPPAEALLLPHGPLR 226
                      P   A   PGP  Q       VS SP+         PP   LL    PL+
Sbjct: 1030 ----------PELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLL---PPLQ 1076

Query: 227  PGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTA 286
            P    +P V P P  V    +   T            +L  K    A  +       L+ 
Sbjct: 1077 PNSGSLPQVLPSPLGVLSGTSRPPTP-----------TLSLKPTPPAPVR-------LSP 1118

Query: 287  APNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSL 346
            AP P S  +L   K       YT   F  AA T          T+       A    + L
Sbjct: 1119 APPPGSSSLL---KPLTVPPGYT---FPPAAATTTSTTTATATTTAVPAPTPA---PQRL 1169

Query: 347  TNQSDWDSPYLDMELARAGSRASEGQG--SGLGGQLS---EVSGRGVQLFEQQ-RQRADS 400
                D  +     E+   G  AS  Q   +  GG      ++ G  + L   Q RQ A  
Sbjct: 1170 ILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVG 1229

Query: 401  STQELAR--VEPAAMLNGEGLQSPPR----AQSAPPEAAVLPPSPLPAPVASPRPFQPGG 454
              + L R  V   +      L S P      Q+  P     P S LP+   S  P   G 
Sbjct: 1230 QPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGL 1289

Query: 455  GAPTPA----PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLG---GLSPAP- 506
              P  A    P++ N +        Q  R   T V   PLAP     S G    L+P P 
Sbjct: 1290 SLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPV--PPLAPAPRPPSSGLPAVLNPRPT 1347

Query: 507  --------PPFLSSQGPTPLPSFTSGVPS--HAPVSGSPSTPRSSGPVTATSSLYIPAPS 556
                    P   +++ P P P+    +    H+P     ++   + P+T +S L++P+  
Sbjct: 1348 LTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSL 1407

Query: 557  RPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISV 616
                    P P + P A+ ++ST S+ LS+ L  S     PAP       P +    ++V
Sbjct: 1408 PGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAP--LTV 1465

Query: 617  PAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDA 676
             A+   +L                      S  P L  +V      P    + + P   A
Sbjct: 1466 SASGPALL---------------------TSVTPPLAPVVPAAPGPPSLAPSGASPSASA 1504

Query: 677  LSLG---AEACNFMQPVG-----ARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 728
            L+LG   A + +  Q  G     A +   +P +     P  +P   P     +P P AP 
Sbjct: 1505 LTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPN 1564

Query: 729  P-------------PSRGLLDGLVNGAASSAGI----PEPPRL-------QGRGGELFAK 764
            P              S+ L   L   AA    I    P PP               + A 
Sbjct: 1565 PAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLAS 1624

Query: 765  RQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQA 824
             Q+         TPG  L      P+PTP L PS   S     P P+  +PL SP   Q 
Sbjct: 1625 SQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPS---STQTMLPAPVP-SPLPSPASTQT 1680

Query: 825  ARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKT-AMFCFDEVPPTPGPIAS--GSPKT 881
                P        ++P Q +         P+  +T ++     + PTP    S    P  
Sbjct: 1681 LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPL 1740

Query: 882  ARVQEIRRFSTPAPQPTAEPLAPT-----VLAPRAAT-TLDEPIWRTELASAPVPSPAPP 935
               Q +     P P   A P+ P       LAP +++ +L  P     L  +P P P   
Sbjct: 1741 GPTQTLSLAPAP-PLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLG 1799

Query: 936  PEAPRGLGASPSS 948
            P A + L  +P+S
Sbjct: 1800 PAAAQTLALAPAS 1812



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 135/549 (24%), Positives = 185/549 (33%), Gaps = 77/549 (14%)

Query: 422  PPRAQSAPPEA----AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQG 477
            PP A +  P +    AVL P P   P   P P      AP P P++     RP    +  
Sbjct: 1325 PPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTL----VRPLLKLVHS 1380

Query: 478  QRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPST 537
              P   S      AP   +  L   S  P P   +  P P+P+ +   P  +PVS + S 
Sbjct: 1381 PSPEV-SASAPGAAPLTISSPLHVPSSLPGP---ASSPMPIPNSS---PLASPVSSTVSV 1433

Query: 538  PRSSG-PVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEA 596
            P SS  P++  ++L  PA +    P  AP   +    A +TS     ++ PL P   P A
Sbjct: 1434 PLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTS-----VTPPLAPVV-PAA 1487

Query: 597  PAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLV 656
            P P   AP   S     +++  A    L  ++  G       P      +S  P L S V
Sbjct: 1488 PGPPSLAPSGASPSASALTLGLATAPSLSSSQTPG------HPLLLAPTSSHVPGLNSTV 1541

Query: 657  QNLDEKPRA-GGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPP 715
                        A + P   A +      + + P  + S      + P   P  A   P 
Sbjct: 1542 APACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPS 1601

Query: 716  PMTPKTPPPV-APKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVV 774
            P  P  P PV AP P +  +L      A+S   +P        G  L +     A     
Sbjct: 1602 PAPPLAPLPVLAPSPGAAPVL------ASSQTPVPVMAPSSTPGTSLASASPVPA----- 1650

Query: 775  EGTPGPGLGPRPRS---PSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKA 831
               P P L P       P+P PS  PS   +  +   P +A  P L    P    +L   
Sbjct: 1651 ---PTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALA--PTLGGSSPSQTLSLGTG 1705

Query: 832  QSQGPRATPKQGIKALDFMRHQPYQL----------KTAMFCFDEVPP------------ 869
              QGP  T    +     +   P Q            T        PP            
Sbjct: 1706 NPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPA 1765

Query: 870  ---TPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTEL-- 924
               T  P +S +   A         +PAP PT  P A   LA   A+T       + L  
Sbjct: 1766 HTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVV 1825

Query: 925  -ASAPVPSP 932
             AS   P P
Sbjct: 1826 SASGAAPLP 1834



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 204/918 (22%), Positives = 302/918 (32%), Gaps = 142/918 (15%)

Query: 91   GPVQSPSPHELQVLS-----PLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDA 145
            GPV    P  L V +     PL P S  PPG  +  PLQP S   P    +  G   S  
Sbjct: 1039 GPVPQVLPASLMVSASPAGPPLIPAS-RPPGPVLLPPLQPNSGSLPQVLPSPLGVL-SGT 1096

Query: 146  DGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWE 205
              P T     +P    P R +P   P     L      P  T P   +   S  ++ +  
Sbjct: 1097 SRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATT 1156

Query: 206  DGA-ALQPPPAEALLLPHGPLRPGPHLIPMVGPVP----HPVAE---DLTTTYTQKAKQA 257
                A  P P   +L P    R     +  +G +      PVA        T+  +  + 
Sbjct: 1157 TAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKL 1216

Query: 258  KLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPH----------------SKGVLMFKKR 301
             L  A+ +++ ++ + +   R +  L++A    H                + G       
Sbjct: 1217 TLTGAQ-VRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVL 1275

Query: 302  RQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMEL 361
                   T    G +    A +   VPPT  +          + +  Q+  D       L
Sbjct: 1276 PSSTPSTTPAPTGLSLPLAANQ---VPPTMVNNTGV-----VKIVVRQAPRDGLTPVPPL 1327

Query: 362  ARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQS 421
            A A    S G  + L  + +   GR +        RA   T  L R  P   L    + S
Sbjct: 1328 APAPRPPSSGLPAVLNPRPTLTPGR-LPTPTLGTARAPMPTPTLVR--PLLKL----VHS 1380

Query: 422  P-PRAQSAPPEAAVLP-------PSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTP 473
            P P   ++ P AA L        PS LP P +SP P        +P  S     + P + 
Sbjct: 1381 PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTV---SVPLSS 1437

Query: 474  GLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSG 533
             L    PTT         P  A+  L  +  + P  +S+ GP  L S T  +    P + 
Sbjct: 1438 SLPISVPTT--------LPAPASAPL-TIPISAPLTVSASGPALLTSVTPPLAPVVPAAP 1488

Query: 534  SPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR 593
             P +   SG   + S+L +   + P     + + P  P   A TS+    L++ + P+  
Sbjct: 1489 GPPSLAPSGASPSASALTLGLATAPSL--SSSQTPGHPLLLAPTSSHVPGLNSTVAPACS 1546

Query: 594  P------EAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS 647
            P         +P P AP P  A+   ++  ++ +  L           M  P       S
Sbjct: 1547 PVLVPASALASPFPSAPNPAPAQASLLAPASSASQALAT-----PLAPMAAPQTAILAPS 1601

Query: 648  PNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP 707
            P P L  L   L   P A    +  +     +   +        A          P   P
Sbjct: 1602 PAPPLAPL-PVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASP-------VPAPTP 1653

Query: 708  PMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQS 767
             +AP +   M P   P   P P S   L  L    A + G   P +    G       Q 
Sbjct: 1654 VLAPSSTQTMLPAPVPSPLPSPASTQTL-ALAPALAPTLGGSSPSQTLSLG---TGNPQG 1709

Query: 768  RADRYVVEGTPGPGLGPRPR---SPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQA 824
                  +  TP   L P P    S +P P L P+   S  +   PP+A     SP  P  
Sbjct: 1710 PFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLS--LAPAPPLA---PASPVGPAP 1764

Query: 825  ARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARV 884
            A TL  A      A+    + A       P  ++T          +P P+ +  P  A+ 
Sbjct: 1765 AHTLTLAP-----ASSSASLLA-------PASVQTLTL-------SPAPVPTLGPAAAQT 1805

Query: 885  QEIRRFSTPAPQPTAEPLA---------PTVLAPRAATTLDEPIWRTELASAPVP----- 930
              +   ST +P   A  L          P  +  R   + DEP   T  +  P P     
Sbjct: 1806 LALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTAT 1865

Query: 931  ---------SPAPPPEAP 939
                      P PPP +P
Sbjct: 1866 SFGGPRPRRQPPPPPRSP 1883



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 197/817 (24%), Positives = 266/817 (32%), Gaps = 193/817 (23%)

Query: 105  SPLSPLSPEPPGAPVPQPLQPG--SLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGP 162
            +P   L+P PP AP P+P   G  ++ +P  +             P     P     R P
Sbjct: 1316 APRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLT-----------PGRLPTPTLGTARAP 1364

Query: 163  TRPTPPGAPPDEVYLSDSPAEPAPTIPGP-PSQGDSRVSSPSWEDGAALQPPPAEALLLP 221
              PTP    P    +     E + + PG  P    S +  PS   G A  P P       
Sbjct: 1365 M-PTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPI------ 1417

Query: 222  HGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIA 281
                   P+  P+  PV   V+  L+++            A +     I    T   +  
Sbjct: 1418 -------PNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGP 1470

Query: 282  SLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFS 341
            +LLT+   P +  V                   AA G  +    G  P++ +       +
Sbjct: 1471 ALLTSVTPPLAPVV------------------PAAPGPPSLAPSGASPSASALT--LGLA 1510

Query: 342  DARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSS 401
             A SL++      P L   LA   S    G  S +    S V      L        + +
Sbjct: 1511 TAPSLSSSQTPGHPLL---LAPTSSHVP-GLNSTVAPACSPVLVPASALASPFPSAPNPA 1566

Query: 402  TQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSP----LPAPVASPRPFQPGGGAP 457
              + + + PA+  +     + P A  A P+ A+L PSP     P PV +P P    G AP
Sbjct: 1567 PAQASLLAPAS--SASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSP----GAAP 1620

Query: 458  ------TPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511
                  TP P +    A   TPG      +        LAP      L    PAP P   
Sbjct: 1621 VLASSQTPVPVM----APSSTPGTSLASASPVPAPTPVLAPSSTQTML----PAPVP--- 1669

Query: 512  SQGPTPLPSFTSGV---PSHAPVSG--SPS------TPRSSGPVTATSSLYIPAPSRPVT 560
               P P P+ T  +   P+ AP  G  SPS      T    GP    +    PA S   T
Sbjct: 1670 --SPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPT 1727

Query: 561  PGG----APEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISV 616
            P      AP PP  P     T T S+  + PL P A P  PAP       P++    +  
Sbjct: 1728 PAQTLSLAPGPPLGP-----TQTLSLAPAPPLAP-ASPVGPAPAHTLTLAPASSSASLLA 1781

Query: 617  PAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDA 676
            PA+             +     P    T      + L+L         A  +   P   A
Sbjct: 1782 PAS------------VQTLTLSPAPVPTLGPAAAQTLAL---------APASTQSPASQA 1820

Query: 677  LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP-------PPVAPKP 729
             SL   A     P+       LP V+   P  +  ++ PP  P T        P   P P
Sbjct: 1821 SSLVVSASG-AAPLPVTMVSRLP-VSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPP 1878

Query: 730  PSRG--LLDGLVNGAASSAGIPEPPRLQGRGGEL---FAKRQSRADRYVVEGT------- 777
            P R    LD L           E  R + R   L   F   ++      V GT       
Sbjct: 1879 PPRSPFYLDSL-----------EEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCT 1927

Query: 778  -PGPGLGP-RPRSPSPTPSLPPSWKYS----------------------------PNIRA 807
             P P   P  PRSP   PS P  W Y+                            P + A
Sbjct: 1928 LPQPVASPIGPRSPG--PSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEA 1985

Query: 808  PPPIAY----NPLLSPFFPQAARTLPKAQSQGPRATP 840
            PPP  +     P L+P   QAA     A    PRA P
Sbjct: 1986 PPPSLHACHPPPWLAP--RQAAFQEQLASELWPRARP 2020



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 162/720 (22%), Positives = 238/720 (33%), Gaps = 130/720 (18%)

Query: 111  SPEPPGAPVPQPLQ------PGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTR 164
            +PE PG  V + L+       G+  +P  S      T +       +E+  RP  R   R
Sbjct: 2387 APERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPR--PR 2444

Query: 165  PTPPGAPPDEVYLSDSPAE--------------PAPTIPGPPSQGD-SRVSSPSWEDGAA 209
            PTP  AP     L   P                P   +P PP        SSP+     A
Sbjct: 2445 PTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPA 2504

Query: 210  LQPPPAEA-------LLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRA 262
              PPPA         L+ P  PL        ++GP   P++  +T        +A+L   
Sbjct: 2505 CTPPPAHTPPPAQTCLVTPSSPL--------LLGPPSVPISASVTNLPLGLRPEAELCAQ 2556

Query: 263  ESLQEKSIKEAKTKCRTIASLLTAAPN---PHSKGVLMFKKRRQRAKKYTLVSFGAAAGT 319
                 +S++ A       +SL    P    P +  +L   ++         +S   +A +
Sbjct: 2557 ALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKN--------LSLTPSAPS 2608

Query: 320  GAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQ 379
               E   +P   E E  + A     ++  + + + P    E        S      L   
Sbjct: 2609 LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGE-ELPLCVSESNGLELPPSAASDEPLQEP 2667

Query: 380  LSEVSGRGVQLFEQQRQRAD-SSTQELARVEPAAMLNGEGLQSPPRAQSA--PPEAAVLP 436
            L E      +L E +   +     QEL   E AA        S P   S   PP      
Sbjct: 2668 L-EADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSA 2726

Query: 437  PSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRAN 496
               +     + RP QP      P P +  +        L G+  T   V+      +R  
Sbjct: 2727 DVEIRGQ-GTGRPGQP------PGPKVLRK--------LPGRLVT---VVEEKELVRRRR 2768

Query: 497  DSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPS 556
               G  S   P    +       S + G PS   +SG  S+P   GP  A  S  +P P 
Sbjct: 2769 QQRGAASTLVPGVSET-------SASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPP 2821

Query: 557  RP-----------VTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPA-PGPGAP 604
            +            VT GG+PE       A +  T         RP  +  +PA  G G  
Sbjct: 2822 QQPFIARRHIELGVTGGGSPE---NGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVD 2878

Query: 605  EPPSAREQRIS-----VPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNL 659
            E PS+  +  +     VP   T I+ +           +P   +  + PNP LLS V   
Sbjct: 2879 EAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNP-LLSPV--- 2934

Query: 660  DEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTP-PPM--------- 709
             EK R G     P+   L +     +          +  PH +P TP PP+         
Sbjct: 2935 -EKRRRG---RPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVA 2990

Query: 710  -----------APKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRG 758
                        PK      PK PP  +P+P    +LD        S G+    + QG+G
Sbjct: 2991 NTVTTVTISTSPPKRKRGRPPKNPP--SPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQG 3048



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 144/607 (23%), Positives = 201/607 (33%), Gaps = 134/607 (22%)

Query: 407  RVEPAAMLNGEGLQSP---PRAQSAPPEAAVLP------------PSPLPAP---VASP- 447
            R+ PA       L  P   P   + PP AA               P+P PAP   + SP 
Sbjct: 1115 RLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPD 1174

Query: 448  -RPFQPGG--------GAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLA-----PK 493
             +   P G         +    P      ++P T  +QG + T T    R LA     P 
Sbjct: 1175 MQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPL 1234

Query: 494  RAND----SLGGL-----SPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPV 544
            + N     S GG       PA    + +  PTP P+         PVS  PS+  S+ P 
Sbjct: 1235 QRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPT---------PVSVLPSSTPSTTP- 1284

Query: 545  TATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPE---APAPGP 601
             A + L +P  +  V          PP+    T    I +    R    P    APAP P
Sbjct: 1285 -APTGLSLPLAANQV----------PPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRP 1333

Query: 602  GAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDE 661
             +   P+    R   P    G L        R  M           P P L+  +  L  
Sbjct: 1334 PSSGLPAVLNPR---PTLTPGRLPTPTLGTARAPM-----------PTPTLVRPLLKLVH 1379

Query: 662  KPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKT 721
             P        PE  A + GA       P+   S  +LP   P + P   P + P  +P +
Sbjct: 1380 SP-------SPEVSASAPGAAPLTISSPLHVPS--SLPG--PASSPMPIPNSSPLASPVS 1428

Query: 722  PPPVAPKPPSRGLLDGLVNGAASSAGIPEP---PRLQGRGGELFAKRQSRADRYVVEGTP 778
                 P   S  +       A +SA +  P   P      G       +     VV   P
Sbjct: 1429 STVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAP 1488

Query: 779  GP-GLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQ-GP 836
            GP  L P   SPS + +L      +P++ +     +  LL+P     +  +P   S   P
Sbjct: 1489 GPPSLAPSGASPSAS-ALTLGLATAPSLSSSQTPGHPLLLAP----TSSHVPGLNSTVAP 1543

Query: 837  RATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ 896
              +P                L  A       P  P P  + +   A        ++ A Q
Sbjct: 1544 ACSPV---------------LVPASALASPFPSAPNPAPAQASLLAP-------ASSASQ 1581

Query: 897  PTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARP 956
              A PLAP + AP+ A           LA +P P  AP P      GA+P     Q   P
Sbjct: 1582 ALATPLAP-MAAPQTAI----------LAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVP 1630

Query: 957  RFSATRT 963
              + + T
Sbjct: 1631 VMAPSST 1637



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 97/432 (22%), Positives = 156/432 (36%), Gaps = 60/432 (13%)

Query: 370  EGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAP 429
            E +G G G + S  +G G     ++ +  +     ++     A    +G    P   +  
Sbjct: 2360 EEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQ 2419

Query: 430  PEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP 489
              +   PP   PA    PRP      AP P P+    SA    P L    P   S     
Sbjct: 2420 TRSTTTPPRCSPARERVPRP------APRPRPT--PASAPAAIPALV---PVPVSAPVPI 2468

Query: 490  LAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSS 549
             AP         + P+PPP      P+ +P  +S  P+  P       P  + P   T  
Sbjct: 2469 SAPNPITILPVHILPSPPP------PSQIPPCSS--PACTPPPACTPPPAHTPPPAQTC- 2519

Query: 550  LYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSA 609
              +  PS P+  G    PP+ P +A++T+         L    RPEA         P S 
Sbjct: 2520 --LVTPSSPLLLG----PPSVPISASVTN---------LPLGLRPEAELCAQALASPESL 2564

Query: 610  REQRISVPAARTGILQEARRRG---TRKQMFRPGKEETKNSPNPELLSL----VQNLDEK 662
              +  SV ++ T  L     +       ++    ++    +P+   L+L    + N  E+
Sbjct: 2565 --ELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQ 2622

Query: 663  PRAGGAESG-----PEEDALSLGAEACNFMQ-PVGARSYKTLPHVTPKTPPPMAPKTPPP 716
                 AE       PE + L L     N ++ P  A S +      P   P  A +T   
Sbjct: 2623 EAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDE------PLQEPLEADRTSEE 2676

Query: 717  MTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYV-VE 775
            +T    P  +P+ P   +   +   + SS+    P   +G       +R++ AD  +  +
Sbjct: 2677 LTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSP---EGPSPARPPRRRTSADVEIRGQ 2733

Query: 776  GTPGPGLGPRPR 787
            GT  PG  P P+
Sbjct: 2734 GTGRPGQPPGPK 2745



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 175/774 (22%), Positives = 250/774 (32%), Gaps = 168/774 (21%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSE--AYYGETDSDADGPA 149
            P  +P P +  +++P SPL   PP  P+   +    L   P++E  A    +    +  +
Sbjct: 2509 PAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELAS 2568

Query: 150  TQEKPRRPRRRGPTRPTPPGA----PPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWE 205
                        P +   P A    P  E  LS +P+ P+ T+            +P   
Sbjct: 2569 VASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSA 2628

Query: 206  DGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESL 265
            +G  L   P E   LP          +P       P+ E L    T              
Sbjct: 2629 EGTTLTVLP-EGEELPLCVSESNGLELPPSAASDEPLQEPLEADRT-------------- 2673

Query: 266  QEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEED 325
              + + EAKT         T++P                 K   LV+   AA        
Sbjct: 2674 -SEELTEAKTP--------TSSPE----------------KPQELVTAEVAA-------- 2700

Query: 326  GVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQ------ 379
              P TS S             T+  +  SP        +      GQG+G  GQ      
Sbjct: 2701 --PSTSSS------------ATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKV 2746

Query: 380  LSEVSGRGVQLFEQ-------QRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPP-- 430
            L ++ GR V + E+       ++QR  +ST      E +A      ++S    +S+PP  
Sbjct: 2747 LRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIG 2806

Query: 431  ---EAAVLPPSPLPAPVASP----RPFQ---PGGGAP----------TPAPSIFNRSARP 470
               EAA  P S LP P   P    R  +    GGG+P          TP P++  R  R 
Sbjct: 2807 GPCEAA--PSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITP-PAVKRRRGR- 2862

Query: 471  FTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP--------PPFLSSQ---GPTPL- 518
              P  + + P                    G  P P         P L  Q   GP PL 
Sbjct: 2863 --PPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLG 2920

Query: 519  --------------PSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGA 564
                               G P  A     P T  S+G   + S    P    P+TP   
Sbjct: 2921 PQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTP-LP 2979

Query: 565  PEPPAPPSAAAMT-STASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI 623
            P    P +  A T +T +I  S P R   RP           PPS R  ++ V    +  
Sbjct: 2980 PLLVCPTATVANTVTTVTISTSPPKRKRGRP--------PKNPPSPRPSQLPVLDRDSTS 3031

Query: 624  LQEARRRGTRKQMFRPGKEETKNSP---NPELLSLVQNLDEKPRAGGAESGPE------E 674
            + E+   G R+Q    G+ E  +S    +  L  L +   E     G +SG        +
Sbjct: 3032 VLESCGLGRRRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQ 3091

Query: 675  DALSLGAEACNFMQPVGARSYKTLPHVTPK---TPPPMAPKTPPPMTPKTPPPVAPKPPS 731
            D L L         P G      +  +TPK   T        PP  T K P   A  P  
Sbjct: 3092 DDLDLADSG-----PGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPV- 3145

Query: 732  RGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPR 785
                 G   G A    +  P  L   G    ++ ++  +    +GTP    GPR
Sbjct: 3146 -----GGSPGLAKRGRLQPPSPLGPEGSVEESEAEASGEEEEGDGTPRRRPGPR 3194



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 137/573 (23%), Positives = 179/573 (31%), Gaps = 114/573 (19%)

Query: 80   LVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYG 139
            L+  V   + E    +P    L + SPL   S  P  A  P P+        P+S     
Sbjct: 1374 LLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPI--------PNSSPLAS 1425

Query: 140  ETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPA-------------P 186
               S    P +   P       P   + P   P    L+ S + PA             P
Sbjct: 1426 PVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVP 1485

Query: 187  TIPGPPSQGDSRVS------------SPSWEDGAALQPPPAEALLLPHGPLRPG------ 228
              PGPPS   S  S            +PS    ++ Q P    LL P     PG      
Sbjct: 1486 AAPGPPSLAPSGASPSASALTLGLATAPSL---SSSQTPGHPLLLAPTSSHVPGLNSTVA 1542

Query: 229  ----PHLIPM--------VGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTK 276
                P L+P           P P P    L    +  ++      A     ++   A + 
Sbjct: 1543 PACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSP 1602

Query: 277  CRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGT-GAEEEDGVP-PTSESE 334
               +A L   AP+P +  VL        A   T V   A + T G       P P     
Sbjct: 1603 APPLAPLPVLAPSPGAAPVL--------ASSQTPVPVMAPSSTPGTSLASASPVPAPTPV 1654

Query: 335  LDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQ 394
            L   +          S   SP     LA A + A    GS     LS  +G     F  Q
Sbjct: 1655 LAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQ 1714

Query: 395  RQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGG 454
                   T  L           + L   P     P +   L P+P   P+A   P  P G
Sbjct: 1715 -------TLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAP---PLA---PASPVG 1761

Query: 455  GAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQG 514
             AP    ++                P ++S     LAP  A+     LSPAP P L    
Sbjct: 1762 PAPAHTLTL---------------APASSSASL--LAP--ASVQTLTLSPAPVPTLGPAA 1802

Query: 515  PTPL---PSFTSGVPSHAP---VSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPP 568
               L   P+ T    S A    VS S + P    PVT  S L + +   P T      PP
Sbjct: 1803 AQTLALAPASTQSPASQASSLVVSASGAAPL---PVTMVSRLPV-SKDEPDTLTLRSGPP 1858

Query: 569  APPSAAAMTSTASIFLSAPLRPSARPEAPAPGP 601
            +PPS A            P RP  +P  P   P
Sbjct: 1859 SPPSTATS-------FGGP-RPRRQPPPPPRSP 1883



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 59/232 (25%), Positives = 79/232 (34%), Gaps = 7/232 (3%)

Query: 64   LSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPL 123
            L+ A ++S     G+ L+L        G   + +P    VL P S L+   P AP P P 
Sbjct: 1509 LATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPA 1568

Query: 124  QPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAP-PDEVYLSDSPA 182
            Q   L   P S A        A   A Q     P    P  P P  AP P    +  S  
Sbjct: 1569 QASLL--APASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQ 1626

Query: 183  EPAPTIPGPPSQGDSRVS-SPSWEDGAALQPPPAEALL---LPHGPLRPGPHLIPMVGPV 238
             P P +    + G S  S SP       L P   + +L   +P     P       + P 
Sbjct: 1627 TPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPA 1686

Query: 239  PHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNP 290
              P     + + T        Q     Q  S+  A +   T A  L+ AP P
Sbjct: 1687 LAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGP 1738


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 115/465 (24%), Positives = 166/465 (35%), Gaps = 65/465 (13%)

Query: 381  SEVSGRGVQLFEQQRQRADSS----TQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLP 436
            SE   RG QL E  + R +S     T  +  + P   +      S P     PP     P
Sbjct: 578  SEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPP 637

Query: 437  PSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRAN 496
            P P P P   P P Q    A + AP     S       LQ     + ++   P  P   +
Sbjct: 638  PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYST---ITRLQNASQHSGALFKPPTPPVMQS 694

Query: 497  DSL--------GGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGP----- 543
             S+         G+ P PPP      P P P+  S +    P   +PS P+ S P     
Sbjct: 695  QSVKPQILVPPNGVVPPPPP------PPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLK 748

Query: 544  ---VTATSSLYIPAPSRPVTPGGAPEPP-APP----SAAAMTSTASIFLSAPLRPSARPE 595
               V   + +  P P  P  P  AP PP APP    +  A TST ++   AP+   A P 
Sbjct: 749  IHQVQHITQVAPPTPPPP-PPIPAPLPPQAPPKPLVTIPAPTSTKTV---APVVTQAAPP 804

Query: 596  APAPGPGAPEPPSAREQRISV----PAARTGILQEARRRGTRKQMFRPGKEETKNSPNPE 651
             P P    P PP+ ++         P+  T  +        ++Q F      +  SP P 
Sbjct: 805  TPTP----PVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPS 860

Query: 652  LLS-LVQNLDEKPRAGGAESGPEEDA-LSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM 709
            ++  +       P     ES P +    ++  ++   ++        ++P  +P  PPP 
Sbjct: 861  VVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPP 920

Query: 710  A---------PKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR--- 757
                      P +P P  P  PPP A   P +    G      SS G  +PP    R   
Sbjct: 921  PESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSS 980

Query: 758  -----GGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPP 797
                 G E    ++   D  V + TP    G   +   P P+ PP
Sbjct: 981  IKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPP 1025



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 102/409 (24%), Positives = 137/409 (33%), Gaps = 86/409 (21%)

Query: 567 PPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI--- 623
           PP  P    +T   +   S PL P   P  P P P  P PP    Q  S P+A +     
Sbjct: 607 PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQ--SAPSAGSAAPMF 664

Query: 624 --------LQEARRRGTRKQMFRPGKEETKNSPN--PELLSLVQNLDEKPRAGGAESGPE 673
                   LQ A +      +F+P       S +  P++L     +   P        P 
Sbjct: 665 VKYSTITRLQNASQHSGA--LFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG 722

Query: 674 EDALSLGAEAC-----NFMQPVGARSYKTLPHVT---PKTPPPMAPKTPPPMTPKTPPP- 724
                L    C      F  P        + H+T   P TPPP  P  P P+ P+ PP  
Sbjct: 723 SAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPP-PPPIPAPLPPQAPPKP 781

Query: 725 --VAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGL 782
               P P S   +  +V  AA     P  P          AK+Q       +  +P    
Sbjct: 782 LVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP---------AKKQPAFPASYIPPSP---- 828

Query: 783 GPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQ 842
            P P  P P P+LP    +      PPP   +P+ S    Q A   P      P  TP  
Sbjct: 829 -PTPPVPVPPPTLPKQQSFCAK---PPPSPLSPVPS-VVKQIASQFP------PPPTPPA 877

Query: 843 GIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPL 902
                  M  QP +            P P  +A  SP   + +       P  QP++ P+
Sbjct: 878 -------MESQPLK------------PVPANVAPQSPPAVKAK-------PKWQPSSIPV 911

Query: 903 -APTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCG 950
            +P    P   ++L  P         P P PAPPP  P     +P   G
Sbjct: 912 PSPDFPPPPPESSLVFP------PPPPSPVPAPPPPPPPTASPTPDKSG 954



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 93/374 (24%), Positives = 130/374 (34%), Gaps = 85/374 (22%)

Query: 398  ADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPF------- 450
            A +ST+ +A V   A         PP  +     A+ +PPSP   PV  P P        
Sbjct: 787  APTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSF 846

Query: 451  --QPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRAN------------ 496
              +P     +P PS+  + A  F P      PT  ++  +PL P  AN            
Sbjct: 847  CAKPPPSPLSPVPSVVKQIASQFPPP-----PTPPAMESQPLKPVPANVAPQSPPAVKAK 901

Query: 497  -----DSLGGLSP---APPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATS 548
                  S+   SP    PPP  S   P P PS     P   P + SP+  +S  P   T 
Sbjct: 902  PKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKT- 960

Query: 549  SLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPS-----------ARPEAP 597
                   S+  +PGG   PP P   +++ S++      P RPS           A   +P
Sbjct: 961  -------SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSP 1013

Query: 598  A----PGPGA-PEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPEL 652
            +    P P A P+P       +++P    G+LQ+         +   GK+     P+P  
Sbjct: 1014 SKETLPPPAAPPKPGKLNLSGVNLP----GVLQQGCVSAKAPVLSGRGKDSVVEFPSP-- 1067

Query: 653  LSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPM--- 709
                      P        P E  L L       ++     S  T P V    P P    
Sbjct: 1068 ----------PSDSDFPPPPPETELPLPP-----IEIPAVFSGNTSPKVAVVNPQPQQWS 1112

Query: 710  ---APKTPPPMTPK 720
                 K PPP  PK
Sbjct: 1113 KMSVKKAPPPTRPK 1126



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 130/548 (23%), Positives = 186/548 (33%), Gaps = 132/548 (24%)

Query: 426  QSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSV 485
            Q APP     PP P+PAP+    P +P    P P  +   ++  P     Q   PT T  
Sbjct: 757  QVAPPTPP--PPPPIPAPLPPQAPPKPLVTIPAPTST---KTVAPVVT--QAAPPTPTPP 809

Query: 486  IFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS--GVPSHAPVSGSPSTPR---S 540
            +  P A K+       + P+PP       P  LP   S    P  +P+S  PS  +   S
Sbjct: 810  V--PPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIAS 867

Query: 541  SGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEA---- 596
              P   T       P +PV    AP+ P    A      +SI + +P  P   PE+    
Sbjct: 868  QFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVF 927

Query: 597  ------PAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS--- 647
                  P P P  P PP+A                      T  +   PGK+ +K S   
Sbjct: 928  PPPPPSPVPAPPPPPPPTASP--------------------TPDKSGSPGKKTSKTSSPG 967

Query: 648  -----PNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVT 702
                 P P+  S +++      + GAE  PE    S+ +    F  P  + S        
Sbjct: 968  GKKPPPTPQRNSSIKS------SSGAEH-PEPKRPSVDSLVSKFTPPAESGS-------- 1012

Query: 703  PKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGI--PEPPRLQGRGGE 760
                         P     PPP AP  P +  L G+        G    + P L GRG +
Sbjct: 1013 -------------PSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKD 1059

Query: 761  LFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYS-PNIRAPPPIAYN--PLL 817
                        VVE        P P S S  P  PP  +   P I  P   + N  P +
Sbjct: 1060 -----------SVVE-------FPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKV 1101

Query: 818  SPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASG 877
            +   PQ  +    +  + P  T  +   +    + +  +  T      +VP +P    S 
Sbjct: 1102 AVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSV 1161

Query: 878  SP-------KTARVQEIRRF-STPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPV 929
             P       +T + + I R  S  +    AEP A          T+D+           +
Sbjct: 1162 QPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTA----------TMDD-----------M 1200

Query: 930  PSPAPPPE 937
              P PPPE
Sbjct: 1201 ALPPPPPE 1208



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 96/393 (24%), Positives = 135/393 (34%), Gaps = 119/393 (30%)

Query: 621 TGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLG 680
           + +  EA +RGT+ +     + E+ N P     SLV  L  +P+                
Sbjct: 574 SSVFSEAWKRGTQLEESSKARMESMNRP---YTSLVPPLSPQPK---------------- 614

Query: 681 AEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAP--KPPSRG----- 733
                 + P       T    +P  PPP  P  PPP  P  PPP  P    PS G     
Sbjct: 615 -----IVTPY------TASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPM 663

Query: 734 -----LLDGLVNGAASSAGI---PEPPRLQGRGGELFAKRQSRADRYVVEGTPGP----- 780
                 +  L N +  S  +   P PP +Q +      K Q       V   P P     
Sbjct: 664 FVKYSTITRLQNASQHSGALFKPPTPPVMQSQS----VKPQILVPPNGVVPPPPPPPPPP 719

Query: 781 -------GLGPRPRSPS------PTPSL------------PPSWKYSPNIRA--PPPIAY 813
                   L P P +PS      P P L            PP+    P I A  PP    
Sbjct: 720 TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP 779

Query: 814 NPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTP-- 871
            PL++   P + +T+    +Q    TP   +         P   K   F    +PP+P  
Sbjct: 780 KPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV---------PPAKKQPAFPASYIPPSPPT 830

Query: 872 -------------------GPIASGSPKTARVQEIRRFSTPAPQPTA---EPL--APTVL 907
                               P +  SP  + V++I     P P P A   +PL   P  +
Sbjct: 831 PPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANV 890

Query: 908 APRAATTLD-EPIWRTELASAPVPSPAPPPEAP 939
           AP++   +  +P W+   +S PVPSP  PP  P
Sbjct: 891 APQSPPAVKAKPKWQP--SSIPVPSPDFPPPPP 921



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 42/167 (25%), Positives = 62/167 (37%), Gaps = 25/167 (14%)

Query: 84  VQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDS 143
           V + A   P     P + Q   P S + P PP  PVP P  P +L   P  +++  +   
Sbjct: 798 VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP--PPTL---PKQQSFCAKPPP 852

Query: 144 DADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPS 203
               P      ++   + P  PTPP        +   P +P P    P S    + + P 
Sbjct: 853 SPLSPVPSVV-KQIASQFPPPPTPPA-------MESQPLKPVPANVAPQSPPAVK-AKPK 903

Query: 204 WEDGAAL-------QPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVA 243
           W+  +          PPP  +L+ P     P P  +P   P P P A
Sbjct: 904 WQPSSIPVPSPDFPPPPPESSLVFP----PPPPSPVPAPPPPPPPTA 946



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 48/198 (24%), Positives = 70/198 (35%), Gaps = 29/198 (14%)

Query: 780 PGLGPRPR------SPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLP---- 829
           P L P+P+      +  P+P LPP     P    PPP    PL S   P A    P    
Sbjct: 607 PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVK 666

Query: 830 -----KAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARV 884
                + Q+    +           M+ Q  + +  +     VPP P P    +P +A  
Sbjct: 667 YSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMA 726

Query: 885 QEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASA------PVPSPAPPPEA 938
           Q       PAP     P  P   AP     + +    T++A        P+P+P PP   
Sbjct: 727 Q-----LKPAP---CAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAP 778

Query: 939 PRGLGASPSSCGFQVARP 956
           P+ L   P+    +   P
Sbjct: 779 PKPLVTIPAPTSTKTVAP 796



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 40/166 (24%), Positives = 61/166 (36%), Gaps = 24/166 (14%)

Query: 99  HELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSP------PDSEAYYGETDSDADGPA--- 149
           H++Q ++ ++P +P PP  P+P PL P +   P      P S        + A  P    
Sbjct: 750 HQVQHITQVAPPTPPPP-PPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTP 808

Query: 150 ----TQEKPRRPRRRGPTRPTPPGA-------PPDEVYLSDSPAEPAPTIPGPPSQGDSR 198
                +++P  P    P  P  P         P  + + +  P  P   +P    Q  S+
Sbjct: 809 PVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ 868

Query: 199 VSSPSWEDGAALQP-PPAEALLLPHGP--LRPGPHLIPMVGPVPHP 241
              P        QP  P  A + P  P  ++  P   P   PVP P
Sbjct: 869 FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP 914



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 36/124 (29%), Positives = 48/124 (38%), Gaps = 10/124 (8%)

Query: 95  SPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSL----RSPPDSEAYYGETDSDADGPAT 150
           SP P  ++ ++   P  P PP A   QPL+P       +SPP  +A      S    P+ 
Sbjct: 856 SPVPSVVKQIASQFPPPPTPP-AMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP 914

Query: 151 QEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAAL 210
              P  P       P PP   P         A P P   G P +  S+ SSP  +     
Sbjct: 915 DFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK----- 969

Query: 211 QPPP 214
           +PPP
Sbjct: 970 KPPP 973



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 49/178 (27%), Positives = 59/178 (33%), Gaps = 55/178 (30%)

Query: 96   PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
            P P E  ++ P  P SP     P P P  P +    PD     G+  S    P  ++ P 
Sbjct: 918  PPPPESSLVFPPPPPSP----VPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPP 973

Query: 156  RPRRRG------------PTRP---------TPP---GAPPDEVYLSDSPAEPAP----- 186
             P+R              P RP         TPP   G+P  E  L    A P P     
Sbjct: 974  TPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKET-LPPPAAPPKPGKLNL 1032

Query: 187  ---TIPGPPSQG--------------DSRVSSPSWEDGAALQPPPAEALLLPHGPLRP 227
                +PG   QG              DS V  PS    +   PPP E  L    PL P
Sbjct: 1033 SGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETEL----PLPP 1086



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 52/224 (23%), Positives = 74/224 (33%), Gaps = 29/224 (12%)

Query: 92  PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
           P  SP P  +   +   P  P PP  P P P  P     PP   +    +   A  P   
Sbjct: 607 PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA-APMFV 665

Query: 152 EKPRRPRRRGPTR--------PTPP-----GAPPDEVYLSDSPAEPAPTIPGPPSQGDSR 198
           +     R +  ++        PTPP        P  +   +    P P  P PP+ G + 
Sbjct: 666 KYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAM 725

Query: 199 VS------SPSWEDGAALQPPPAEALLLPH-----GPLRPGPHLIPMVGP---VPHPVAE 244
                   +PS    +A  PPP +   + H      P  P P  IP   P    P P+  
Sbjct: 726 AQLKPAPCAPSLPQFSA-PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVT 784

Query: 245 DLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAP 288
               T T+       Q A       +  AK +    AS +  +P
Sbjct: 785 IPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP 828



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 4/66 (6%)

Query: 127 SLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAP 186
           S+ S   SEA+   T  +    A  E   RP     T   PP +P  ++    + ++P+P
Sbjct: 571 SIVSSVFSEAWKRGTQLEESSKARMESMNRPY----TSLVPPLSPQPKIVTPYTASQPSP 626

Query: 187 TIPGPP 192
            +P PP
Sbjct: 627 PLPPPP 632


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 198/869 (22%), Positives = 281/869 (32%), Gaps = 222/869 (25%)

Query: 59   VSCTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAP 118
            +  T L H   + L      +L        + GP++  +P  L+V++  SP  PEP  A 
Sbjct: 584  IGITKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPAD 643

Query: 119  VPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEK-------PRRPRRR----------- 160
               P       S    E     T     GP T++        PR   R+           
Sbjct: 644  CQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHM 703

Query: 161  ---------GPTRPTPPGAPPDEVYLSDSPAE-------------------PAPTIPGPP 192
                     GP  P+ P +   E  L + PA                      P +PG P
Sbjct: 704  SSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKP 763

Query: 193  SQ----GDSRVSSPSWEDGAALQPPPAEALLLPHGP------LRPGPHLIPMV------- 235
             Q    G S  + P  +     +P   +AL  PHGP      ++P P L+P         
Sbjct: 764  RQVLPPGTSHFTPP--QTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPR 821

Query: 236  ----------------------------GPVPHPVAEDLTTTYTQKAKQAK----LQRAE 263
                                        GP P PV   + T        A+     +RA 
Sbjct: 822  SLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAH 881

Query: 264  SLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEE 323
            SL   +  +++ +   +  L+ AA  P++       +RR           GA       +
Sbjct: 882  SLNRYAASDSEPERDEL--LVPAAAGPYAT-----VQRRVGRSHSVRAPAGADKNVNRSQ 934

Query: 324  EDGVPPTSESELDE--EAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLS 381
               V P  +       +  S A +  N +D   P  + E    G RA   + S L G + 
Sbjct: 935  SFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVD 994

Query: 382  EVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLP 441
              S   V+                     AAML    +    RA   PPE     P+P P
Sbjct: 995  TGSAGSVKSI-------------------AAMLELSSIGGGGRAARRPPEGH---PTPRP 1032

Query: 442  APVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            A   SP P    G   T   S+ ++ A      +  +R T +  +   LA  R      G
Sbjct: 1033 A---SPEP----GRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGP---G 1082

Query: 502  LSPAPPPFLSS-------QGPTPLPSFTSGVPSHAPVSGSPSTPR---------SSGPVT 545
             S  P PF+         +GP+   +   G P  A V  S +  R          +    
Sbjct: 1083 ESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPL-AKVEASATLKRRIRAKQNQQENVKFI 1141

Query: 546  ATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPE 605
             T S  +    +       PEPP PP +     T ++        +  PE P P P A  
Sbjct: 1142 LTESDTVKRRPKAKEREAGPEPP-PPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEP 1200

Query: 606  PPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRA 665
            PP+       +P        EAR         +P K     SP P L   V  L   P  
Sbjct: 1201 PPTDLAHLPPLPPPE----GEAR---------KPAKPPV--SPKPVLTQPVPKLQGSP-- 1243

Query: 666  GGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP-PMAPKTPPPMTPK-TPP 723
                                        + K +P   P +P    A  TPPP++PK  PP
Sbjct: 1244 --------------------------TPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPP 1277

Query: 724  PVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLG 783
            P APKP     + GL +G+A  +  P P             RQ  A      GTP P LG
Sbjct: 1278 PTAPKPVK--AVAGLPSGSAGPSPAPSP------------ARQPPAALAKPPGTP-PSLG 1322

Query: 784  PRPRSPSPTPSLPPSWKYSPNIRAPPPIA 812
              P  P P+P  P     + ++ A PP A
Sbjct: 1323 ASPAKP-PSPGAP-----ALHVPAKPPRA 1345



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 64/214 (29%), Positives = 89/214 (41%), Gaps = 23/214 (10%)

Query: 422  PPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPT 481
            PP A+  P + A LPP  LP P    R  +P     +P P +     +P  P LQG  PT
Sbjct: 1195 PPPAEPPPTDLAHLPP--LPPPEGEAR--KPAKPPVSPKPVL----TQP-VPKLQGS-PT 1244

Query: 482  TTSV---IFRPLAP--KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPS 536
             TS    +  P +P  KRA+ +   +SP PPP      P P+ +  +G+PS     GS  
Sbjct: 1245 PTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPP--PPTAPKPVKA-VAGLPS-----GSAG 1296

Query: 537  TPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEA 596
               +  P     +     P  P + G +P  P  P A A+   A    +A    +A    
Sbjct: 1297 PSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAP 1356

Query: 597  PAPGPGAPEPPSAREQRISVPAARTGILQEARRR 630
            PAP  GA    SAR++     A     LQ    +
Sbjct: 1357 PAPPEGASPGDSARQKLEETSACLAAALQAVEEK 1390



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 124/599 (20%), Positives = 186/599 (31%), Gaps = 114/599 (19%)

Query: 422  PPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPT 481
            P  +   PP+         P  +  P    P      P P +   + RP +P    Q PT
Sbjct: 769  PGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPT 828

Query: 482  TTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPR-- 539
                 +    P           PAPPP  ++     LP      P   P   + S  R  
Sbjct: 829  HRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGR-PKKRAHSLNRYA 887

Query: 540  SSGPVTATSSLYIPAPSRPVTP-----GGAPEPPAPPSAAAMTSTASIFLSAPLRPSARP 594
            +S        L +PA + P        G +    AP  A    + +  F   P +    P
Sbjct: 888  ASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPP 947

Query: 595  EAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLS 654
              P     A    +  ++ +       G+L    R   R+     G  +T ++ + + ++
Sbjct: 948  PPPKRSSSALASANLADEPVPDAEPEDGLL--GVRAQCRRASDLAGSVDTGSAGSVKSIA 1005

Query: 655  LVQNLDEKPRAGGAESGPEE-------------------------DALSLGAEACNFMQP 689
             +  L      G A   P E                         +A+  G E  N  + 
Sbjct: 1006 AMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRT 1065

Query: 690  VGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIP 749
            +       L   T +  P  +   P P          P+ PS+G            AG+ 
Sbjct: 1066 LSGPVTGLL--ATARRGPGESAD-PGPFVEDGTGRQRPRGPSKG-----------EAGVE 1111

Query: 750  EPP------------RLQGRGGEL-----------FAKRQSRADRYVVEGTPGP------ 780
             PP            R++ +  +              KR+ +A        P P      
Sbjct: 1112 GPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYH 1171

Query: 781  -GLGPRPRSPSPTPSLPPSWKYSPNIRAPPP--IAYNPLLSPFFPQAARTLPKAQSQGPR 837
             G G   R P+   + PP     P    PPP  +A+ P L P         P+ +++ P 
Sbjct: 1172 NGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPP---------PEGEARKPA 1222

Query: 838  ATPKQGIKALDFMRHQPY-QLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ 896
              P      L     QP  +L+ +     +  P PGP   GSP+  R        TP P 
Sbjct: 1223 KPPVSPKPVLT----QPVPKLQGSPTPTSKKVPLPGP---GSPEVKRAH-----GTPPPV 1270

Query: 897  PTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPA--------PPPEAPRGLGASPS 947
                P  PT   P  A      +       +P PSPA         PP  P  LGASP+
Sbjct: 1271 SPKPPPPPTAPKPVKAVA---GLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPA 1326



 Score = 34.7 bits (78), Expect = 0.45
 Identities = 33/104 (31%), Positives = 38/104 (36%), Gaps = 16/104 (15%)

Query: 106  PLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGP--ATQEKPRRPRRRG-- 161
            P+SP  P PP AP P     G     P   A      S A  P  A  + P  P   G  
Sbjct: 1269 PVSPKPPPPPTAPKPVKAVAGL----PSGSAGPSPAPSPARQPPAALAKPPGTPPSLGAS 1324

Query: 162  PTRPTPPGAP--------PDEVYLSDSPAEPAPTIPGPPSQGDS 197
            P +P  PGAP        P     + + A   P  P   S GDS
Sbjct: 1325 PAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDS 1368



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 56/231 (24%), Positives = 80/231 (34%), Gaps = 37/231 (16%)

Query: 742 AASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG-LGPRPRSPS----PTPSLP 796
           A  S   PEP     +  ++   + S     +     GP  +GP    PS    PTP   
Sbjct: 630 AIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRAT 689

Query: 797 PSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQS----QGPR-ATPKQGIKALDFMR 851
                S   RA    +   LL    P  +  + ++Q     +GP   TP +  +     R
Sbjct: 690 TRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARP---GR 746

Query: 852 HQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRA 911
           H  + +K A      VPP PG             + R+   P       P  PT   P +
Sbjct: 747 HG-HSIKRA-----SVPPVPG-------------KPRQVLPPGTSHFTPPQTPTKTRPGS 787

Query: 912 ATTLDEPIWRTELASAPVPSPA--PP---PEAPRGLGASPSSCGFQVARPR 957
              L  P       +   P+P   PP   P +PR L  SP+  GF    P+
Sbjct: 788 PQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQ 838


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/594 (25%), Positives = 207/594 (34%), Gaps = 111/594 (18%)

Query: 394 QRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPG 453
           +R RA  +   L R  P+A       + P ++ S+  E +   PSP     A+ R    G
Sbjct: 169 RRSRAAGTEVGLPRPAPSARPRPP-TEGPRKSVSSASEHSTTEPSP-----AARRRPSAG 222

Query: 454 GGAPTPAPSIFNRSARPFT-PGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSS 512
           GG   PA    + SA P + P   G     T     P AP   +       P P    + 
Sbjct: 223 GGLQRPASRSLSSSATPLSSPARSGPSARGT-----PRAPAHPSQ------PKPKGLQAL 271

Query: 513 QGPTPLPSFTSGVPSHAPVSGSP-STPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571
           + P   P      P+  P+S SP +TP  S P         P+PS P +    P PPA P
Sbjct: 272 RPPQVTPPRKDAAPALGPLSSSPLATPSPSAP---------PSPSAPPSLQTLPSPPATP 322

Query: 572 SAAAMTS--------TASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI 623
            + A TS        T S   S PL P A P   AP P    PP   +   S PA+    
Sbjct: 323 PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP-PALALPP--LQAPPSPPAS---- 375

Query: 624 LQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQ---NLDEKPRAGGAESGPEEDALSLG 680
                          P    +  +PN   + L+Q   +    P      S P    +S  
Sbjct: 376 -----------PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424

Query: 681 AEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVN 740
           A   +   P  A          P   PP  P +PP     TPPP AP P +   L     
Sbjct: 425 ATPPSQAPPSLA--------APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476

Query: 741 GAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSP-SPTPSLPPSW 799
              +   +  PP                     ++  P P      ++P SP+ SLP S 
Sbjct: 477 PPQAPPALATPP---------------------LQALPSPPASFPGQAPFSPSASLPMSP 515

Query: 800 KYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKT 859
             +P  +APP +A   L  P  P A+ TL     Q PR  P  G    D     P +L  
Sbjct: 516 LATPPPQAPPVLAAPLLQVPPSPPASPTL-----QAPRRPPTPG---PDTSVSGP-RLTL 566

Query: 860 AMFCFDEVPPTPGPIAS---------GSPKTARVQEIRRF-STPAPQPTAEPLAPTVLAP 909
           A+      PP+  P ++          S  T+  +E+R + S P     A P     LA 
Sbjct: 567 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 626

Query: 910 -RAATTLDEPIWRTELASAP-VPSPAPPPEAPRGLGASPSSCGFQVARPRFSAT 961
              A     P        AP  P P PP   P   G++   C         SAT
Sbjct: 627 CHPAAWSRGPAPPLAFRGAPGAPLPWPPATGP---GSADGLCTIYETEGPESAT 677



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 198/778 (25%), Positives = 266/778 (34%), Gaps = 166/778 (21%)

Query: 110 LSPEPPGAP-VPQPLQPGSLRSPPDSEAYYGETDSD-ADGPATQEKPRRPRRRGPTRPTP 167
           L+P PPG+P  P P+ P +LR    + A   +  ++ A G      P    R GPTR + 
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSR 84

Query: 168 PGAPPDEVYLSDSPAEPAP----TIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHG 223
           P A            E AP    T PGP       VSSP    G                
Sbjct: 85  PPA--------SGRGERAPPAKNTSPGP-------VSSPGRASGTT-------------- 115

Query: 224 PLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASL 283
             RPGP     +G     ++ + T     + K  +  +  +L   + ++           
Sbjct: 116 --RPGP-----LGQKGLRISAEETVA---RGKATEAPKRSALSAGARRD----------- 154

Query: 284 LTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDA 343
            T+ P P +    M ++ R             AAGT    E G+P  + S          
Sbjct: 155 -TSGPTPGTPSPAMARRSR-------------AAGT----EVGLPRPAPSARPRPPTEGP 196

Query: 344 RSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLS-EVSGRGVQLFEQQRQRADSST 402
           R   + +   S       AR    A    G GL    S  +S     L    R    +  
Sbjct: 197 RKSVSSASEHSTTEPSPAARRRPSA----GGGLQRPASRSLSSSATPLSSPARSGPSARG 252

Query: 403 QELARVEPAAMLNGEGLQ-------SPPRAQSAPPEAAVLPPSPL--PAPVASPRPFQPG 453
              A   P +    +GLQ       +PPR + A P    L  SPL  P+P A P P  P 
Sbjct: 253 TPRAPAHP-SQPKPKGLQALRPPQVTPPR-KDAAPALGPLSSSPLATPSPSAPPSPSAPP 310

Query: 454 GGAPTPAPSIFNRSARPF---TPGLQGQRPTTTSVIFRPLA--PKRANDSLGGLSP--AP 506
                P+P     S       +P LQ       S    PLA  P +A  +L  L P  AP
Sbjct: 311 SLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL-ALPPLQAP 369

Query: 507 PPFLSSQGPTPLPSFTSGVPSHAPVS--GSPSTPRSSGPVTATSSLYIPAPSRPVTPGGA 564
           P   +S   +PL + +   P+   V    +P +P  S PV A  S   P  S PV+P   
Sbjct: 370 PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS---PPASPPVSPSAT 426

Query: 565 PEPPAPPSAAA--MTSTASIFLSAPLRPSARPEAPAPGP-GAPEPPSAREQRISVPAART 621
           P   APPS AA  +    S   S P+ PSA P   AP P  AP    A+    + PA  T
Sbjct: 427 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486

Query: 622 GILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGA 681
             LQ                    + P     S   +L   P A      P         
Sbjct: 487 PPLQAL-------------PSPPASFPGQAPFSPSASLPMSPLATPPPQAP--------- 524

Query: 682 EACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTP----------PPVAPKPPS 731
                  PV A     +P   P +P   AP+ PP   P T            P  P PPS
Sbjct: 525 -------PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 577

Query: 732 R---GLLDG--LVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRP 786
           R     L G  L   ++S+   PE  R    G E  A      D  +    P        
Sbjct: 578 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW----S 633

Query: 787 RSPSPTPSLPPSWKYSPNIRAPPPIAYNP--------LLSPFFPQAARTLPKAQSQGP 836
           R P+P    P +++ +P    P P A  P        +     P++A   P A   GP
Sbjct: 634 RGPAP----PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 687



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 133/552 (24%), Positives = 183/552 (33%), Gaps = 96/552 (17%)

Query: 424 RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTT 483
           +   A   AA   P+     + +PRP     G+P P P        P TP          
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTPRP----PGSPRPPP--------PVTPAALRVLGAAG 51

Query: 484 SVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSS-G 542
           +V  +PLA +      GG+  A  P      P   P+ TS  P+      +P    +S G
Sbjct: 52  AVGRKPLAERA-----GGIGGATIP---ESAPRAGPTRTSRPPASGRGERAPPAKNTSPG 103

Query: 543 PVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPG 602
           PV++           P+   G     A  + A   +T +   SA L   AR +   P PG
Sbjct: 104 PVSSPGRASGTTRPGPLGQKGL-RISAEETVARGKATEAPKRSA-LSAGARRDTSGPTPG 161

Query: 603 APEPPSAREQR-----ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQ 657
            P P  AR  R     + +P             G RK +     E +   P+P       
Sbjct: 162 TPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV-SSASEHSTTEPSPA------ 214

Query: 658 NLDEKPRAGGAESGPEEDALSLGAEACNFMQPVG--ARSYKTLP-HVTPKTPPPMAPKTP 714
               +P AGG    P   +LS  A   +     G  AR     P H +   P  +    P
Sbjct: 215 -ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP 273

Query: 715 PPMTP-----------------KTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 757
           P +TP                  TP P AP  PS            S   +P PP     
Sbjct: 274 PQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS---------APPSLQTLPSPPATP-- 322

Query: 758 GGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLL 817
             +      S   +      P P L P     +P P  PP+    P ++APP    +P L
Sbjct: 323 PSQATTSLGSPTLQATHSFLPSPPLSP---LATPPPQAPPALALPP-LQAPPSPPASPPL 378

Query: 818 SPF---FPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPI 874
           SP     PQA   L     Q P + P             P Q   +      V P+  P 
Sbjct: 379 SPLATPSPQAPNALAVHLLQAPFSPPPS----------PPVQAPFSPPASPPVSPSATPP 428

Query: 875 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934
           +   P  A          P   P + P++P+   P  A           LA+ P+    P
Sbjct: 429 SQAPPSLAAPP----LQVPPSPPASPPMSPSATPPPQAP--------PPLAAPPLQLAKP 476

Query: 935 PPEAPRGLGASP 946
           PP+AP  L   P
Sbjct: 477 PPQAPPALATPP 488



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 72/273 (26%), Positives = 94/273 (34%), Gaps = 46/273 (16%)

Query: 704 KTPPPMAPK--TP-PPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAG-IPEPPRLQGRGG 759
           +TP   AP   TP PP +P+ PPPV P           V GAA + G  P   R  G GG
Sbjct: 15  RTPAARAPGLLTPRPPGSPRPPPPVTPAALR-------VLGAAGAVGRKPLAERAGGIGG 67

Query: 760 ELFAKRQSRADRYVVEGTPGPGLGPR-PRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLS 818
               +   RA        P  G G R P + + +P    S   +     P P+    L  
Sbjct: 68  ATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRI 127

Query: 819 PFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGS 878
                 AR   KA     R+    G +                   D   PTP     G+
Sbjct: 128 SAEETVAR--GKATEAPKRSALSAGARR------------------DTSGPTP-----GT 162

Query: 879 PKTARVQEIRRFST----PAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934
           P  A  +  R   T    P P P+A P  PT    ++ ++  E        + P P+   
Sbjct: 163 PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE-----HSTTEPSPAARR 217

Query: 935 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQA 967
            P A  GL    S      A P  S  R+G  A
Sbjct: 218 RPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 50/159 (31%), Positives = 65/159 (40%), Gaps = 13/159 (8%)

Query: 92  PVQSP-SPHELQVLSPLSPLSPEPPGAPVPQPLQ-PGSLRSPPDSEAYYGETDSDADGP- 148
           P+Q+P SP     LSPL+  SP+ P A     LQ P S    P  +A +    S    P 
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424

Query: 149 ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208
           AT      P    P    PP +PP    +S S A P P  P P +    +++ P  +   
Sbjct: 425 ATPPSQAPPSLAAPPLQVPP-SPPASPPMSPS-ATPPPQAPPPLAAPPLQLAKPPPQAPP 482

Query: 209 ALQPPPAEALLLP------HGPLRPGPHL--IPMVGPVP 239
           AL  PP +AL  P        P  P   L   P+  P P
Sbjct: 483 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPP 521



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 26/165 (15%)

Query: 88  ADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           A  GP    +P      +P  P  P+P G    +P Q     +PP  +A      + A G
Sbjct: 244 ARSGPSARGTPR-----APAHPSQPKPKGLQALRPPQV----TPPRKDA------APALG 288

Query: 148 PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDG 207
           P +      P    P+ P  P APP    L   P+ PA     PPSQ  + + SP+ +  
Sbjct: 289 PLSSSPLATP---SPSAPPSPSAPPS---LQTLPSPPAT----PPSQATTSLGSPTLQAT 338

Query: 208 AALQP-PPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYT 251
            +  P PP   L  P     P   L P+  P   P +  L+   T
Sbjct: 339 HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT 383



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 105/474 (22%), Positives = 145/474 (30%), Gaps = 66/474 (13%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P  LQ L P     P    AP   PL    L +P  S        S +  P+ Q  P 
Sbjct: 263 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAP-----PSPSAPPSLQTLPS 317

Query: 156 RPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
            P        T  G+P  +   S  P+ P   +  PP Q    ++ P       LQ PP+
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP------PLQAPPS 371

Query: 216 EALLLPHGPL-RPGP--------HLI----------PMVGPVPHPVAEDLTTTYTQKAKQ 256
                P  PL  P P        HL+          P+  P   P +  ++ + T  ++ 
Sbjct: 372 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 431

Query: 257 AKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAA 316
                A  LQ      A       A+    AP P +   L   K   +A          A
Sbjct: 432 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP--------PA 483

Query: 317 AGTGAEEEDGVPPTS---ESELDEEAFSDARSLTNQSDWDSPYLDMELAR------AGSR 367
             T   +    PP S   ++     A      L        P L   L +      A   
Sbjct: 484 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 543

Query: 368 ASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQS-PPRAQ 426
               +     G  + VSG  + L          S        P++ L+G  L      A 
Sbjct: 544 LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR------SPSSTLSGPDLAGHSSSAT 597

Query: 427 SAPPEAAVLPPSPLPAPVASPRP------FQPGGGAPTPAPSIFNRSA----RPFTPGLQ 476
           S P E       P     ASP P        P   +  PAP +  R A     P+ P   
Sbjct: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 657

Query: 477 GQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAP 530
                    I+    P+ A  + G L P P P   + G        +G  S +P
Sbjct: 658 PGSADGLCTIYETEGPESATPAPGALDPGPSP--GTSGGKAAAGAGAGASSRSP 709


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 106/436 (24%), Positives = 141/436 (32%), Gaps = 83/436 (19%)

Query: 417 EGLQSPP-RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGL 475
           +G  SPP + Q  PP+    P  P P P     P   GG  P   P       +P  P  
Sbjct: 48  QGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP----PGKPQGPPP 103

Query: 476 QGQRPTTTSVIFRPLAPKRANDSLGGLSP--APPPFLSSQGPTPLPSFTSGVPSHAPVSG 533
           QG +  +      P    +     GG  P   PPP    QGP P        P   P  G
Sbjct: 104 QGDKSRSPR---SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ---GGNKPQGPPPPG 157

Query: 534 SPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR 593
            P  P   G   + SS   P   +   P G  +P  PP               P +   +
Sbjct: 158 KPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ------GPPPQGGNK 211

Query: 594 PEAPAPGPGAPE-PPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPEL 652
           P+ P P PG P+ PP   + +     +  G  Q    +G  +    P        P P+ 
Sbjct: 212 PQGPPP-PGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ- 269

Query: 653 LSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK 712
                N  + P   G   GP       G+++ +   P G           P+ PPP    
Sbjct: 270 ---GGNKPQGPPPPGKPQGPPPQG---GSKSRSSRSPPG----------KPQGPPPQGGN 313

Query: 713 -----TPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQS 767
                 PPP  P+ PPP                G     G P P + QG   +  +K +S
Sbjct: 314 QPQGPPPPPGKPQGPPP---------------QGGNKPQGPPPPGKPQGPPPQGGSKSRS 358

Query: 768 RADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAART 827
                              RSP   P  PP  + +     PPP   N       PQ  + 
Sbjct: 359 ------------------ARSPPGKPQGPPQQEGNNPQGPPPPAGGN-------PQQPQA 393

Query: 828 LPKAQSQGPRATPKQG 843
            P  Q QGP   P+ G
Sbjct: 394 PPAGQPQGPPRPPQGG 409



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 104/428 (24%), Positives = 135/428 (31%), Gaps = 92/428 (21%)

Query: 519 PSFTSGVPSHAPVSGS------PSTP------------RSSGPVTATSSLYIPAPSRPVT 560
           PS  +G P  AP  G       PS P            +  GP         P P     
Sbjct: 29  PSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 88

Query: 561 PGGAPEPPAPPSAAAMTSTASIFLSAPLRPSA-------RPEAPAPGPGAPEPP----SA 609
           P G P P  P         +    S P +P         +P+ P P PG P+ P      
Sbjct: 89  PQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGN 148

Query: 610 REQRISVPAARTGILQEARRRGTRKQMFRPGKEETK-----NSPNPELLSLVQNLDEKPR 664
           + Q    P    G   +   + +R     PGK +       N P        +     P+
Sbjct: 149 KPQGPPPPGKPQGPPPQGDNK-SRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 207

Query: 665 AGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK-----TPPPMTP 719
            G    GP       G       +   ARS    P   P+ PPP          PPP  P
Sbjct: 208 GGNKPQGPPPPGKPQGPPPQGDNKSQSARS----PPGKPQGPPPQGGNQPQGPPPPPGKP 263

Query: 720 KTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQG---RGGELFAKRQSRADRYVVEG 776
           + PPP                G     G P P + QG   +GG     R SR+     +G
Sbjct: 264 QGPPP---------------QGGNKPQGPPPPGKPQGPPPQGGS--KSRSSRSPPGKPQG 306

Query: 777 TPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGP 836
            P  G G +P+ P P P  P         + PPP   N    P         P  + QGP
Sbjct: 307 PPPQG-GNQPQGPPPPPGKP---------QGPPPQGGNKPQGP--------PPPGKPQGP 348

Query: 837 RATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQ 896
              P QG       R  P + +         P  P P A G+P+  +       + PA Q
Sbjct: 349 ---PPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQ-------APPAGQ 398

Query: 897 PTAEPLAP 904
           P   P  P
Sbjct: 399 PQGPPRPP 406



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 52/167 (31%), Positives = 64/167 (38%), Gaps = 18/167 (10%)

Query: 70  MSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQ--PLQPGS 127
           M LI  S   L L+  +  +E   Q  SP     L   +P    P G   PQ  P  PG 
Sbjct: 1   MLLILLSVALLALSSAQNLNEDVSQEESPS----LIAGNPQGAPPQGGNKPQGPPSPPGK 56

Query: 128 LRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG---PTRPTPPG---APPDEVYLSDSP 181
            + PP         +     P    KP+ P  +G   P  P PPG    PP +   S SP
Sbjct: 57  PQGPPPQGG-----NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSP 111

Query: 182 AEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPG 228
             P     GPP QG ++   P    G    PPP +    P GP  PG
Sbjct: 112 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-QGGNKPQGPPPPG 157



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 43/133 (32%), Positives = 55/133 (41%), Gaps = 14/133 (10%)

Query: 109 PLSPEPPGAPVPQPLQPG----SLRSPPDS-EAYYGETDSDADGPATQE-KPRRPRRRG- 161
           P  P PPG P   P Q      S RSPP   +    +  +   GP     KP+ P  +G 
Sbjct: 150 PQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 209

Query: 162 --PTRPTPPGAPPDEVYLSDSPAEPAPTIPG----PPSQGDSRVSSPSWEDGAALQPPPA 215
             P  P PPG P       D+ ++ A + PG    PP QG ++   P    G    PPP 
Sbjct: 210 NKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP- 268

Query: 216 EALLLPHGPLRPG 228
           +    P GP  PG
Sbjct: 269 QGGNKPQGPPPPG 281



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 42/132 (31%), Positives = 49/132 (37%), Gaps = 13/132 (9%)

Query: 109 PLSPEPPGAPVPQPLQPGSL----RSPPDS-EAYYGETDSDADGPATQE-KPRRPRRRGP 162
           P  P PPG P   P Q GS     RSPP   +    +  +   GP     KP+ P  +G 
Sbjct: 274 PQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 333

Query: 163 TRPT-------PPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPA 215
            +P        P G PP     S S   P     GPP Q  +    P    G   Q P A
Sbjct: 334 NKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQA 393

Query: 216 EALLLPHGPLRP 227
                P GP RP
Sbjct: 394 PPAGQPQGPPRP 405



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 46/143 (32%), Positives = 54/143 (37%), Gaps = 20/143 (13%)

Query: 106 PLSPLSPEPPGAPVPQ-PLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG--- 161
           P  P  P P G   PQ P  PG  + PP       + D      +   KP+ P  +G   
Sbjct: 75  PGKPQGPPPQGGNKPQGPPPPGKPQGPPP------QGDKSRSPRSPPGKPQGPPPQGGNQ 128

Query: 162 PTRPTPP-----GAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAE 216
           P  P PP     G PP        P  P     GPP QGD++  S     G    PPP +
Sbjct: 129 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP-QGPPPQGDNKSRSSRSPPGKPQGPPP-Q 186

Query: 217 ALLLPHGPLRPGPHLIPMVGPVP 239
               P GP  P P   P  GP P
Sbjct: 187 GGNQPQGP--PPPPGKPQ-GPPP 206



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 46/143 (32%), Positives = 53/143 (37%), Gaps = 19/143 (13%)

Query: 106 PLSPLSPEPPGAPVPQ-PLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRG--- 161
           P  P  P P G   PQ P  PG  + PP       ++     G     KP+ P  +G   
Sbjct: 198 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPG-----KPQGPPPQGGNQ 252

Query: 162 PTRPTPP-----GAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAE 216
           P  P PP     G PP        P  P     GPP QG S+  S     G    PPP +
Sbjct: 253 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP-QGPPPQGGSKSRSSRSPPGKPQGPPP-Q 310

Query: 217 ALLLPHGPLRPGPHLIPMVGPVP 239
               P GP  P P   P  GP P
Sbjct: 311 GGNQPQGP--PPPPGKPQ-GPPP 330



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 36/124 (29%), Positives = 47/124 (37%), Gaps = 12/124 (9%)

Query: 420 QSPP-RAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQG- 477
           +SPP + Q  PP+    P  P P P     P   GG  P   P       +P  P  QG 
Sbjct: 298 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP----PGKPQGPPPQGG 353

Query: 478 -QRPTTTSVIFRPLAP--KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGS 534
            +  +  S   +P  P  +  N+  G   P PP   + Q P   P+     P   P  G 
Sbjct: 354 SKSRSARSPPGKPQGPPQQEGNNPQG---PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGR 410

Query: 535 PSTP 538
           PS P
Sbjct: 411 PSRP 414


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 221/979 (22%), Positives = 315/979 (32%), Gaps = 175/979 (17%)

Query: 97   SPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRR 156
            +P +     P +P  P  P  P P P  P  L +PP            A  P  + +P  
Sbjct: 499  APDKRLKAEPAAP--PAAPSTPAPPPAVPKELPAPP--------APPPASAPTPETEPEE 548

Query: 157  PRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAE 216
            P +  P + TP         L       + T  G           PS E      P P E
Sbjct: 549  PAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEG-----PEPPE 603

Query: 217  ALLLPHGPLRPGPHLIPM---VGPVPHPVAEDLTTTYTQKAKQAKLQRAES---LQEKSI 270
             +  P  P  P P + P    +GP   P ++ L     QK+   + QR +    L+++  
Sbjct: 604  EVPPPTTP--PVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQ 661

Query: 271  KEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPT 330
             + +   +  A      P+P     L      Q         +  A G         PP 
Sbjct: 662  HQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRP-------PPM 714

Query: 331  SESELDEE-----AFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSG 385
                 D        + D R L  +   D  +    +  +G    E   SG  G  SE   
Sbjct: 715  PPMNFDPRWMMIPPYVDPRLLQGRPPLD--FYPPGVHPSGLVPRERSDSG--GSSSEPFD 770

Query: 386  RGV--QLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAV---LPPSPL 440
            R     L E+     D     +  V  A       L SP R  +   +  +    PP P 
Sbjct: 771  RHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPP 830

Query: 441  PAPVASPRPFQPGGGAPTPAPSIF-----NRSARPFTPG------LQGQRP------TTT 483
            P P  +  P  P  GAP P  S F          P+ PG      +Q   P        T
Sbjct: 831  PPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEET 890

Query: 484  SVIFRPLAPKRANDSLGGLSPAPPP------FLSSQGPTPLPSFTSGVPSHAPVSGSPST 537
            + +  P A ++    +G     PPP        +  GP P  S   G+P   P  G+P  
Sbjct: 891  AQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRP-GSSRRGIPPEEP--GAP-- 945

Query: 538  PRSSGPV--TATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPE 595
            PR +GP+      +     P +P+  G   E P PP    +  T         +     E
Sbjct: 946  PRRAGPIKKPPPPTKVEELPPKPLEQG--DETPKPPKPDPLKITKG-------KLGGPKE 996

Query: 596  APAPGPGAPEPPSARE---QRISVPAARTGILQE--ARRRGTRKQMFRPGKEETKNSPNP 650
             P  G  +P P   R+   +R+   + R     E  AR RG R      G    + + + 
Sbjct: 997  TPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRG----RGARSR 1052

Query: 651  ELLSLVQNLDEKPRAGGAESGPEEDALSLG-------AEACNFMQPVGARSYKTLPHVTP 703
            E  S  +   +  R GG   GP       G       +E   + +    R  +     + 
Sbjct: 1053 EFRSYREFRGDDGRGGGT-GGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSE 1111

Query: 704  KTPPPMAPKTPPPMTPK----TPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGG 759
                 +AP      TPK    T  P+AP PP          GA  S   P P R   RGG
Sbjct: 1112 THESDLAPSDKEAPTPKEGTLTQVPLAPPPP----------GAPPS---PAPARFTARGG 1158

Query: 760  ELFAKRQSRADRYVVEGTPGPGLGP--RPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLL 817
             +F  R   + R    G P P + P   P + S  P  PP+         P P +  PL 
Sbjct: 1159 RVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPT--------GPLPPSKEPLK 1210

Query: 818  SPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASG 877
                P     + +  S G      +  +     RH   Q +       + PP    +   
Sbjct: 1211 EKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQ-------DKPPRFRRLKQE 1263

Query: 878  SPKTARVQEIR-RFSTPAPQPTAEPLAPTVL---APRAATTLDEPI-----------WRT 922
                AR  E +   + PA  P  E    TV    APR A      +           W T
Sbjct: 1264 RENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWET 1323

Query: 923  ELASAPVPS------PAPPPE--APRGLGASPSSCGFQV------------------ARP 956
               S+   S       APPP    P+ +G      G  V                  ++ 
Sbjct: 1324 ASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKR 1383

Query: 957  RFSATRTGLQAHVWRPGAG 975
             FS+ R G++    RPG G
Sbjct: 1384 SFSSQRPGMERQNRRPGPG 1402



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 141/563 (25%), Positives = 188/563 (33%), Gaps = 91/563 (16%)

Query: 418 GLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQG 477
           GLQ P      PP   ++PP   P  +  P P+ P G    P P   +R  R   P   G
Sbjct: 234 GLQ-PSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSG 292

Query: 478 QRPTTTSVIFRPLAPKRAN------------DSLGGLSPA---PPPFLSSQGPTPLPSFT 522
                   + RP   K  N            D   G             S       S  
Sbjct: 293 PPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDE 352

Query: 523 SGVPSHAP---VSGSPSTPRSSG------------PVTATSSLYIPAPSRPVTPGGAPEP 567
            G   H      SG    P + G            P TA +    P  + P  P  AP+P
Sbjct: 353 EGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPP--APKP 410

Query: 568 PAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA 627
           P PP               P R     + PAP     E  + R++R    +  +  ++ A
Sbjct: 411 PLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAP---EDEDEAWRQRRKQSSSEISLAVERA 467

Query: 628 RRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFM 687
           RRR  R++  R  +EE + +   +L    + LDEK  A       E  A           
Sbjct: 468 RRR--REEEERRMQEERRAACAEKL----KRLDEKFGAPDKRLKAEPAA----------- 510

Query: 688 QPVGARSYKTLPHVTPKTPPPMAPKTPPPM---TPKTPPPV-APKPPSRGLLDGLVNGAA 743
            P  A S    P   PK  P  AP  PPP    TP+T P   A  PP++         + 
Sbjct: 511 -PPAAPSTPAPPPAVPKELP--APPAPPPASAPTPETEPEEPAQAPPAQ---------ST 558

Query: 744 SSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSP 803
            + G+   P L   GG   +      +   VE       GP P    P P+ PP  K  P
Sbjct: 559 PTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEP 618

Query: 804 NIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFC 863
                 P    P     +P+  ++LP    +  R   +Q +K     + Q +Q  +A   
Sbjct: 619 KGDGIGPTRQPPSQGLGYPKYQKSLP---PRFQRQQQEQLLKQQQQHQWQQHQQGSA--- 672

Query: 864 FDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTE 923
               PPTP P +   P T         + PAPQ  A P  P  L P A   L  P     
Sbjct: 673 ----PPTPVPPSPPQPVTLG-------AVPAPQ--APPPPPKALYPGA---LGRPPPMPP 716

Query: 924 LASAPVPSPAPPPEAPRGLGASP 946
           +   P     PP   PR L   P
Sbjct: 717 MNFDPRWMMIPPYVDPRLLQGRP 739



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 220/979 (22%), Positives = 304/979 (31%), Gaps = 240/979 (24%)

Query: 133  DSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPP 192
            DS+    E   D+   + +E+P  P   G    +P   PP         + P  T PGPP
Sbjct: 349  DSDEEGAEGHRDSQSASGEERP--PEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPP 406

Query: 193  SQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQ 252
            +        P     A    PP +       P R GP       P   P  ED    + Q
Sbjct: 407  APKPPL--PPPHRGPAGNWGPPGDY------PDRGGP-------PCKPPAPEDEDEAWRQ 451

Query: 253  KAKQAKLQ----------RAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRR 302
            + KQ+  +          R E  + +  +E +  C      L        K     + + 
Sbjct: 452  RRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDK-----RLKA 506

Query: 303  QRAKKYTLVSFGAAAGTGAEEEDGVP-------PTSESELDEEAFSD-ARSLTNQSDWDS 354
            + A      S  A      +E    P       PT E+E +E A +  A+S        +
Sbjct: 507  EPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAA 566

Query: 355  PYLDMELARAGSRASEGQGS----GLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEP 410
            P L   ++  GS +S   GS     +  QL    G      E   +    +T  + +VEP
Sbjct: 567  PTL---VSGGGSTSSTSSGSFEASPVEPQLPSKEGP-----EPPEEVPPPTTPPVPKVEP 618

Query: 411  AAMLNG-------EGLQSPPRAQSAPP----------------------EAAVLPPSPLP 441
                 G       +GL  P   +S PP                      +    PP+P+P
Sbjct: 619  KGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVP 678

Query: 442  APVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP----LAPKRAND 497
                 P P QP      PAP       +   PG  G+ P    + F P    + P     
Sbjct: 679  -----PSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPR 733

Query: 498  SLGGLSPAP--PPFLSSQGPTPLPSFTSGVPS------HAPV----SGSP---------- 535
             L G  P    PP +   G  P     SG  S      HAP      G+P          
Sbjct: 734  LLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVG 793

Query: 536  ----STPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPS 591
                +TP    P+T+          + +     P PP PP  A+          AP  P 
Sbjct: 794  DVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPE--NGAPGPPI 851

Query: 592  ARPEAPAPGP-GAPEPPSARE-QRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPN 649
            +R     PGP   P PP + E  +I  P  +                  P KEET     
Sbjct: 852  SRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKK----------------EPPKEETAQLTG 895

Query: 650  PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP-- 707
            PE          KP  G    G         +       P    S + +P   P  PP  
Sbjct: 896  PE-------AGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRR 948

Query: 708  --PMAPKTPPPMTPKTPP---------PVAPKPPSRGLLDGLVNG---AASSAGIPEPPR 753
              P+    PP    + PP         P  PKP    +  G + G      +  +   PR
Sbjct: 949  AGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPR 1008

Query: 754  L--------------QGRG-GELFAK-----------------------RQSRADRYVVE 775
            L              +GRG GE FA+                       R+ R D     
Sbjct: 1009 LRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGG 1068

Query: 776  GTPGPGLGPRP--RSPSPTPSLPPSWKYSPNIR-----APPPIAYNPLLSPFFPQAARTL 828
            GT GP   P P  R+ S T S    ++  P  R           +   L+P   +A    
Sbjct: 1069 GTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPK 1128

Query: 829  PKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGP---IASG----SPKT 881
                +Q P A P  G                        PP+P P    A G    +P+ 
Sbjct: 1129 EGTLTQVPLAPPPPG-----------------------APPSPAPARFTARGGRVFTPRG 1165

Query: 882  ARVQEIRRFSTPAPQ--PTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAP 939
               +  R    P PQ  P   P A + LAP+   T   P  +  L    +P P  P    
Sbjct: 1166 VPSRRGRGGGRPPPQVCPGWSPPAKS-LAPKKPPTGPLPPSKEPLKEKLIPGPLSP--VA 1222

Query: 940  RGLGASPSSCGFQVA-RPR 957
            RG     S+ G +   RPR
Sbjct: 1223 RGGSNGGSNVGMEDGERPR 1241



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 204/921 (22%), Positives = 287/921 (31%), Gaps = 186/921 (20%)

Query: 106  PLSPLSPEPPGAPVPQPLQPGS-----LRSPPDSEAYYGETDSDADGPATQEKPRRPRRR 160
            P+S    E PG P P P  PGS     +++PP  +    E  +   GP    KP R    
Sbjct: 850  PISRFPLEEPG-PRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGS 908

Query: 161  GPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLL 220
            G   P PP              E        P  G SR   P  E GA    PP  A   
Sbjct: 909  GGQGPPPPRR------------ESRTETRWGPRPGSSRRGIPPEEPGA----PPRRA--- 949

Query: 221  PHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTI 280
              GP++  P    +    P P+ +   T    K    K+ + +    K            
Sbjct: 950  --GPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKE----------- 996

Query: 281  ASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAF 340
                   PN    G L    R +R   Y  V   +  G G  E                 
Sbjct: 997  -----TPPN----GNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRG- 1046

Query: 341  SDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADS 400
              ARS   +S     Y +        R  +G+G G GG     + RG    E + + ++ 
Sbjct: 1047 RGARSREFRS-----YREF-------RGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEY 1094

Query: 401  STQELARVEPAAMLNGEGLQSP--PRAQSAP-PEAAVLPPSPLPAPVASPRPFQPGGGAP 457
                  R +  +    E  +S   P  + AP P+   L   PL  P        P G  P
Sbjct: 1095 EEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPP--------PPGAPP 1146

Query: 458  TPAPSIFN-RSARPFTP-------GLQGQRPTTT-----SVIFRPLAPKRANDSLGGLSP 504
            +PAP+ F  R  R FTP       G  G RP        S   + LAPK+     G L P
Sbjct: 1147 SPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKP--PTGPLPP 1204

Query: 505  APPPFLSSQGPTPLPSFTSGVPS-----------------HAPVSGSPSTPR-------- 539
            +  P      P PL     G  +                 H         PR        
Sbjct: 1205 SKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQER 1264

Query: 540  ------SSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTAS------------ 581
                  S G  + T     P P   +T       PAP  AAA +   S            
Sbjct: 1265 ENAARGSEGKPSLTLPASAPGPEEALTT--VTVAPAPRRAAAKSPDLSNQNSDQANEEWE 1322

Query: 582  -IFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPG 640
                S+      R +  AP P    P +          A  GI   A  RG   Q  +  
Sbjct: 1323 TASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGI--SAMSRGDLSQRAKDL 1380

Query: 641  KEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPH 700
             + + +S  P +    +  + +P  GG ++G    +   G          G    ++ P 
Sbjct: 1381 SKRSFSSQRPGM----ERQNRRPGPGG-KAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPS 1435

Query: 701  VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEP-PRLQGRGG 759
               ++ PP   +  PP  P  PPP +     R  LD +++  ++ AGI +   +L  R G
Sbjct: 1436 PKNRSRPP---EERPPGLPLPPPPPSSSAVFR--LDQVIH--SNPAGIQQALAQLSSRQG 1488

Query: 760  ELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSP 819
             + A       +        PGL   P+ PSP P         P    P  +       P
Sbjct: 1489 SVTAPGGHPRHK--------PGLPQAPQGPSPRP---------PTRYEPQRVNSGLSSDP 1531

Query: 820  FFPQAARTLPKAQSQGPRATPKQ--GIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASG 877
             F +     P    +G   TP+   G+      R +    K  +   + +PP       G
Sbjct: 1532 HFEE-----PGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLG 1586

Query: 878  SPKTARVQEIRRFSTPAPQPTAEPLAPTVLAP----RAATTLDEPIWRTELASAPVPSPA 933
            S              P PQ  +       L P    R  T      +R   +  P   P 
Sbjct: 1587 SKPEG----------PGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPS-SMEPWMEPL 1635

Query: 934  PPPEAPRGLGASPSSCGFQVA 954
             P E   G   S S  G  ++
Sbjct: 1636 SPFEDVAGTEMSQSDSGVDLS 1656



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 226/1057 (21%), Positives = 324/1057 (30%), Gaps = 215/1057 (20%)

Query: 97   SPHELQVLSPLSPLSPE---PPGAPVPQPLQP-----GSLRSPPDSEAYYGETDSDADG- 147
            SP E Q+ S   P  PE   PP  P    ++P     G  R PP     Y +        
Sbjct: 587  SPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPR 646

Query: 148  ----------PATQEKPRRPRRRGPTRPTP-PGAPPDEVYLSDSPAEPAPTIPG----PP 192
                         Q+   +  ++G   PTP P +PP  V L   PA  AP  P     P 
Sbjct: 647  FQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPG 706

Query: 193  SQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHP---VAEDLTTT 249
            + G      P   D   +  PP     L  G  RP     P   P  HP   V  + + +
Sbjct: 707  ALGRPPPMPPMNFDPRWMMIPPYVDPRLLQG--RPPLDFYP---PGVHPSGLVPRERSDS 761

Query: 250  YTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAP--------------NPHSKGV 295
                ++         L+E+       K   +  + TA P              +   KG+
Sbjct: 762  GGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGM 821

Query: 296  LMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEA---------FSDARSL 346
                        Y L S+      GA      PP S   L+E             +   +
Sbjct: 822  RSETPPVPPPPPY-LASYPGFPENGAPG----PPISRFPLEEPGPRPLPWPPGSDEVAKI 876

Query: 347  TNQSDWDSPYLDMELARAGSRASE--GQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQE 404
                    P  +      G  A     +G G GGQ      R  +   +   R  SS + 
Sbjct: 877  QTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRG 936

Query: 405  LARVEPAAMLNGEG-LQSPP---RAQSAPP------EAAVLPPSPLPAPVAS-----PRP 449
            +   EP A     G ++ PP   + +  PP      +    PP P P  +       P+ 
Sbjct: 937  IPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKE 996

Query: 450  FQPGGGAPTPAPSI---------------------FNRSARPFTPGLQGQRPTTTSVIFR 488
              P G   +PAP +                     +    R F     G+     S  FR
Sbjct: 997  TPPNGNL-SPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFR 1055

Query: 489  PLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSG-----VPSHAPVSGSPSTPRSSGP 543
                 R +D  GG +  P    + +G T   + + G     +P      GS +   +   
Sbjct: 1056 SYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES 1115

Query: 544  VTATSSLYIPAPSRPV---TPGGAPEPPAPPSAAAMTSTAS---IFL--SAPLR------ 589
              A S    P P        P   P P APPS A    TA    +F     P R      
Sbjct: 1116 DLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGG 1175

Query: 590  -----------PSARPEAPAPGPGAPEPPSAREQRISV------PAARTGI---LQEARR 629
                       P A+  AP   P  P PPS    +  +      P AR G          
Sbjct: 1176 RPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGME 1235

Query: 630  RGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQP 689
             G R +  R G+ + ++ P P    L Q  +   R  G+E  P   +L+L A A    + 
Sbjct: 1236 DGERPRRRRHGRAQQQDKP-PRFRRLKQERENAAR--GSEGKP---SLTLPASAPGPEEA 1289

Query: 690  VGARSYKTLPHVTPKTPPPMAPKTPPPMTPK-------------------TPPPVAPKPP 730
            +   +    P       P ++ +       +                    PPPV   P 
Sbjct: 1290 LTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPK 1349

Query: 731  SRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVE--------------- 775
            + G   G   GA           L  R  +L +KR   + R  +E               
Sbjct: 1350 AVGTPGGGGGGAVPGISAMSRGDLSQRAKDL-SKRSFSSQRPGMERQNRRPGPGGKAGSS 1408

Query: 776  ------------GTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFF-- 821
                        G  GPG G +   PSP     P  +  P +  PPP    P  S  F  
Sbjct: 1409 GSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPP---PPSSSAVFRL 1465

Query: 822  PQAARTLPKAQSQG-PRATPKQGIKAL--DFMRHQPYQLKTAMFCFDEVPPTPGPIASGS 878
             Q   + P    Q   + + +QG         RH+P   +          P+P P     
Sbjct: 1466 DQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQ------GPSPRPPTRYE 1519

Query: 879  PK--TARVQEIRRFSTPAPQPT---AEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPA 933
            P+   + +     F  P P        P     ++P      + P  + EL         
Sbjct: 1520 PQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQ---EESL 1576

Query: 934  PPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVW 970
            PPP +   LG+ P   G Q A  R + T   L  H+W
Sbjct: 1577 PPPHSSGFLGSKPEGPGPQ-AESRDTGTE-ALTPHIW 1611



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 173/758 (22%), Positives = 235/758 (31%), Gaps = 176/758 (23%)

Query: 94   QSPSPHELQVLSPLSPLSPEPPGAP--------------------VPQPLQPGSLRSPPD 133
            ++P+P E  +     PL+P PPGAP                    VP     G  R PP 
Sbjct: 1123 EAPTPKEGTLTQV--PLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPP- 1179

Query: 134  SEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPS 193
                  +       PA    P++P    PT P PP   P +  L   P  P   +    S
Sbjct: 1180 ------QVCPGWSPPAKSLAPKKP----PTGPLPPSKEPLKEKLIPGPLSP---VARGGS 1226

Query: 194  QGDSRVSSPSWE------DGAALQ---PPPAEALLLPHGPLRPG----PHL-IPMVGPVP 239
             G S V     E       G A Q   PP    L         G    P L +P   P P
Sbjct: 1227 NGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGP 1286

Query: 240  HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFK 299
                E LTT     A +    ++  L  ++  +A  +        TA+ +          
Sbjct: 1287 E---EALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWE------TASESSDFTSERRGD 1337

Query: 300  KRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFS-DARSLTNQSDWDSPYLD 358
            K        T  + G   G G     G+   S  +L + A     RS ++Q     P ++
Sbjct: 1338 KEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQ----RPGME 1393

Query: 359  MELARAG--------SRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEP 410
             +  R G          +S G G G GG+     GRG        +R+  S +  +R  P
Sbjct: 1394 RQNRRPGPGGKAGSSGSSSGGGGGGPGGRTG--PGRG-------DKRSWPSPKNRSR-PP 1443

Query: 411  AAMLNGEGLQSPPRAQSAPPEA-AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSAR 469
                 G  L  PP + SA      V+  +P     A  +     G    P     ++   
Sbjct: 1444 EERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGL 1503

Query: 470  PFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHA 529
            P  P     RP T         P+R N  L     +  P     GP              
Sbjct: 1504 PQAPQGPSPRPPTR------YEPQRVNSGL-----SSDPHFEEPGPM------------- 1539

Query: 530  PVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLR 589
             V G   TPR S  V+            P  P     PP  P      S      S  L 
Sbjct: 1540 -VRGVGGTPRDSAGVS------------PFPPKRRERPPRKPELLQEESLPPPHSSGFL- 1585

Query: 590  PSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPN 649
              ++PE P P           E R +   A T  +       T ++ +RP   E    P 
Sbjct: 1586 -GSKPEGPGP---------QAESRDTGTEALTPHIWNRLHTATSRKSYRPSSME----PW 1631

Query: 650  PELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARS-----YKTLPHVTPK 704
             E LS  +++       G E    +  + L  ++     P   RS      K      PK
Sbjct: 1632 MEPLSPFEDV------AGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPK 1685

Query: 705  TPPPMAP------KTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRG 758
             P   +P      + PP   P   PP AP    R  L             P PP      
Sbjct: 1686 RPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKEL---------PREQPLPP------ 1730

Query: 759  GELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLP 796
            G +  +R  R DR         G  P P  PS  P  P
Sbjct: 1731 GPIGTERSQRTDR---------GTEPGPIRPSHRPGPP 1759



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 148/644 (22%), Positives = 197/644 (30%), Gaps = 159/644 (24%)

Query: 420 QSPPRAQSA----PPEAAVLPPSPLPA------PVASPR--PFQPGG------------- 454
           QS P++  A    PPE+  LP S  PA      P A+P   P  P G             
Sbjct: 92  QSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGA 151

Query: 455 -GAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSS- 512
            G    A S+ +R +R   P LQ       +   R  A     +   G  P+  P  S+ 
Sbjct: 152 HGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESA-----EQSSGPGPSLRPQNSTT 206

Query: 513 ------QGPTPLPSFTSGV-PSHAPVSG-SPSTPRSSGPVTATSSLYIPAPSRPVTPGGA 564
                 +GP  L    S +   H P  G  PS P    P       ++  P  P  P   
Sbjct: 207 WRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYG 266

Query: 565 PEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAP-GPGAPEPPSAREQRISVPAARTGI 623
           P+ P                  P  PS  P    P G G P        R+  P  R  I
Sbjct: 267 PQGP-------------YRYPTPDGPSRFPRVAGPRGSGPP-------MRLVEPVGRPSI 306

Query: 624 LQE-------------------ARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR 664
           L+E                   A       +  +   EE     + E     +   +   
Sbjct: 307 LKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEE---GAEGHRDSQS 363

Query: 665 AGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPP-------- 716
           A G E  PE D     +       P  A +  + P  T   PP   P  PPP        
Sbjct: 364 ASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNW 423

Query: 717 -----MTPKTPPPVAPKPPSRGLLDGLVNGAASSAGI------------PEPPRLQGRGG 759
                   +  PP  P  P             SS+ I             E  R+Q    
Sbjct: 424 GPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERR 483

Query: 760 ELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSP 819
              A++  R D     G P   L   P +P   PS P          APPP     L +P
Sbjct: 484 AACAEKLKRLDEKF--GAPDKRLKAEPAAPPAAPSTP----------APPPAVPKELPAP 531

Query: 820 FFPQAA-----RTLPKAQSQGP--RATPKQGIKALDFM---------------RHQPYQ- 856
             P  A      T P+  +Q P  ++TP  G+ A   +                  P + 
Sbjct: 532 PAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEP 591

Query: 857 ---LKTAMFCFDEV-PPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAA 912
               K      +EV PPT  P+    PK   +   R+   P  Q    P     L PR  
Sbjct: 592 QLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQ---PPSQGLGYPKYQKSLPPRFQ 648

Query: 913 TTLDEPI--------WRTELASAPVPSPAPP-PEAPRGLGASPS 947
               E +        W+     +  P+P PP P  P  LGA P+
Sbjct: 649 RQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPA 692



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 111/457 (24%), Positives = 148/457 (32%), Gaps = 104/457 (22%)

Query: 125  PGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEP 184
            P S RS PD     G     A+GP     P+RP    P    P   PP     S+ P  P
Sbjct: 1665 PCSQRSSPD-----GGLKGAAEGP-----PKRPGGSSPLNAVPCEGPPG----SEPPRRP 1710

Query: 185  APTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPH-------GPLRPGPHLIPMVGP 237
             P     P  GD R   P  +    L P P               GP+RP     P V  
Sbjct: 1711 PPA----PHDGD-RKELPREQP---LPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQF 1762

Query: 238  VPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPN--PHSK-- 293
                   DL        K      AE     S+ EA    R    L +AA +  P SK  
Sbjct: 1763 GTSDKDSDLRLVVGDSLK------AEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNL 1816

Query: 294  --GVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSD 351
              G  + +      + Y  V +G+A  + ++   G        +D +   ++      + 
Sbjct: 1817 DSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGA-------MDSQLHPNSGGFRPGTP 1869

Query: 352  WDSPYLDMELARAGSRASEG---QGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARV 408
               PY    L      A       G  L GQ  + S                   EL ++
Sbjct: 1870 SLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFS--------------TMQATELGKL 1915

Query: 409  EPAAMLNGEG--LQSPPRAQSAPPEAAVLPP-SPLPAPVAS-PRPFQPGGGA---PTPAP 461
                +L      L SP    S  P+ ++L     LP+P      P QPGG +   P+ AP
Sbjct: 1916 PAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAP 1975

Query: 462  SIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSF 521
            +      +   P +  Q P                 + G L PAPPP      P PL   
Sbjct: 1976 A-----QQMLLPMVDSQLPVV---------------NFGSLPPAPPP-----APPPLSLL 2010

Query: 522  TSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRP 558
              G     P    PS      P  AT  L  P+P+RP
Sbjct: 2011 PVG-----PALQPPSLAVRPPPAPATRVL--PSPARP 2040



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 64/297 (21%), Positives = 90/297 (30%), Gaps = 71/297 (23%)

Query: 85  QRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPP------------ 132
           Q  A   PV    P  + + +  +P +P PP    P+ L PG+L  PP            
Sbjct: 669 QGSAPPTPVPPSPPQPVTLGAVPAPQAPPPP----PKALYPGALGRPPPMPPMNFDPRWM 724

Query: 133 ------DSEAYYGETDSDADGPATQEKPRRPRRRGPT------------------RPTPP 168
                 D     G    D   P        PR R  +                  R TPP
Sbjct: 725 MIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPP 784

Query: 169 GAPPDEVYLSD----SPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGP 224
              P   ++ D    +PAEP P +  P  Q           +   + PPP      P  P
Sbjct: 785 -VDPKLAWVGDVFTATPAEPRP-LTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFP 842

Query: 225 LR--PGPHLI------PMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTK 276
               PGP +       P   P+P P   D          + +  + E+ Q    +  +  
Sbjct: 843 ENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKP 902

Query: 277 CRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAE----EEDGVPP 329
            R + S     P P             R +  T   +G   G+       EE G PP
Sbjct: 903 ARGVGSGGQGPPPP-------------RRESRTETRWGPRPGSSRRGIPPEEPGAPP 946



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 36/112 (32%), Positives = 45/112 (40%), Gaps = 16/112 (14%)

Query: 422  PPRAQSAPPEAAVLPPSP-LPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP 480
            PP    APP  ++LP  P L  P  + RP       P PA  +    ARPF   L   R 
Sbjct: 1997 PPAPPPAPPPLSLLPVGPALQPPSLAVRP------PPAPATRVLPSPARPFPASL--GRA 2048

Query: 481  TTTSVIFRPLAP-KRANDSLG--GLSPAPPPFLSSQGPT----PLPSFTSGV 525
                V  +P    ++ + +LG  G S  PP   S  G        PS  SGV
Sbjct: 2049 ELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGV 2100



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 64/261 (24%), Positives = 91/261 (34%), Gaps = 49/261 (18%)

Query: 490 LAPKRANDSLGGLS-------PAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSG 542
           +AP+    SLG ++       PA  P L ++     P+  S VP     +G  S    S 
Sbjct: 38  VAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPN-VSLVPKDG--TGWASKQEQSD 94

Query: 543 PVTATSSLYIPAPSRPVTPGGAP---EPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAP 599
           P ++ +S   P  S+P+     P   +P  PP+A   T      + +  + S    A   
Sbjct: 95  PKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGD 154

Query: 600 GPGAPEPPSAREQRISVPAARTGILQE--ARRRGTRKQMFRPGKEETKNSPNPELLSLVQ 657
           G G      +R  R   P  +    Q+  A+ R + +Q   PG             SL  
Sbjct: 155 G-GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGP------------SLRP 201

Query: 658 NLDEKPRAGGAESGPEE-----DALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK 712
                 R GG   GP+E       L  G +    +QP G               PP  P 
Sbjct: 202 QNSTTWRDGGGR-GPDELEGPDSKLHHGHDPRGGLQPSG---------------PPQFPP 245

Query: 713 TPPPMTPKTPPPVAPKPPSRG 733
               M P   PP  P PP  G
Sbjct: 246 YRGMMPPFMYPPYLPFPPPYG 266



 Score = 30.8 bits (68), Expect = 6.5
 Identities = 38/162 (23%), Positives = 54/162 (33%), Gaps = 18/162 (11%)

Query: 88  ADEGPVQSPSPHELQVL-SPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDAD 146
           +D    Q P    L    +P S     PP AP   PL P  ++S   +   +G     A 
Sbjct: 98  SDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHG-----AH 152

Query: 147 GPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWED 206
           G   +      R      PT   A   +    +  +    + PGP  +     +S +W D
Sbjct: 153 GDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ---NSTTWRD 209

Query: 207 GAALQPPPAEALLL-------PHGPLRPG--PHLIPMVGPVP 239
           G    P   E           P G L+P   P   P  G +P
Sbjct: 210 GGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMP 251


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 107/395 (27%), Positives = 131/395 (33%), Gaps = 103/395 (26%)

Query: 436 PPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRA 495
           PP P PAP       +P GG+P P+P     S  P  P L                    
Sbjct: 141 PPPPGPAPGPPQDISEPPGGSPLPSPP----STAPPPPPLL------------------- 177

Query: 496 NDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAP 555
                 L P PPP   S  P P P   +  P H     SPS P     +     L   AP
Sbjct: 178 ------LEPPPPP---SMAPPPPPVLEALSPPH--TLSSPSIPTPPDFIPPAPPLAFLAP 226

Query: 556 SRPVTPGGAPEPPAPP------------------SAAAMTSTASIFLSAPLRPSARPEAP 597
             P  P  AP  PA P                    A     A    ++P R  A P+  
Sbjct: 227 PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGS 286

Query: 598 APGPGAPEPPSAREQRISVP---AARTGIL--QEARRRGTRKQMFRPGKEETKNSPNPEL 652
           A GP  PEP     +   VP     RT  +  QEA+          P KEE      P  
Sbjct: 287 ALGPN-PEPHLTFPRSFKVPPPTPVRTSSIPVQEAQE--------APRKEEGATKKAPSR 337

Query: 653 LSLVQNLDEKPRAG-GAESGPEEDAL-SLGAEACNFMQPVGARSYKTLPHVTPK--TPPP 708
           L L  +   +P +    +  PE D    L A A     P   R  ++      +  TPPP
Sbjct: 338 LPLPPSFHIRPASQVYPDRAPEPDCPGELKATA-----PASPRLGQSQSQADERAGTPPP 392

Query: 709 MAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSR 768
            AP  PPP  P  PPP  P PP+   L      A   AG  + P+               
Sbjct: 393 -APPLPPP-APPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK--------------- 435

Query: 769 ADRYVVEGTPGPGLGPRPRSPSP---TPSLPPSWK 800
                   +  P L P+P  PSP     S P  W+
Sbjct: 436 --------SSSPALKPKPNPPSPENTASSAPVDWR 462



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 155/618 (25%), Positives = 211/618 (34%), Gaps = 130/618 (21%)

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIF 464
           L  + P   L+   + +PP      P  A L P P P P  +P         P PA S  
Sbjct: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---------PAPA-SPH 243

Query: 465 NRSARPFTPG----------LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFL---- 510
               R F PG          L G++   T     P +P     S   L P P P L    
Sbjct: 244 TVGTRLFPPGGVTKWKSDVALNGRQAEATRA-SPPRSPAEPKGS--ALGPNPEPHLTFPR 300

Query: 511 SSQGPTPLPSFTSGVP----SHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPE 566
           S + P P P  TS +P      AP     +T ++   +    S +I  P+  V P  APE
Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RPASQVYPDRAPE 359

Query: 567 PPAPPSAAAMTSTASIFLS-------------APLRPSARPEAPAPGPGAPEPPSAREQR 613
           P  P    A T+ AS  L               P  P   P  P P P  P PP+A    
Sbjct: 360 PDCPGELKA-TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAP--- 415

Query: 614 ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPE 673
             +P A+      A    T K    P  +   N P+PE  +    +D +       S  E
Sbjct: 416 -PLPCAQKAAHPPAGFTKTPKSS-SPALKPKPNPPSPENTASSAPVDWRD-----PSQME 468

Query: 674 EDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP----PMAPK-----------TPPPMT 718
           +    L A  C   +     S++  P V P++      P  P+           TPP + 
Sbjct: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528

Query: 719 PKT----------------------PPPVAPKPPSRGL---LDGLVNGAASSAGIPE--- 750
            K+                       P  +P P  R +   L+  ++ AA     P    
Sbjct: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588

Query: 751 -PPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPP 809
            PP+ +  GG +    ++ AD   +       L P+  +  PT SL P     P I  PP
Sbjct: 589 LPPKPRLEGGRIC---ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAI--PP 643

Query: 810 PIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869
                P + P       T PKA + GP ATP                LK        +  
Sbjct: 644 KATPEPAIPPKATLWPATPPKA-TLGP-ATP----------------LKATSGPTTPLKA 685

Query: 870 TPGP----IASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELA 925
           T GP     A+  P T       + S PA QP  +P +  V  P  A     P   T L 
Sbjct: 686 TSGPAIASTATTLPTTTSQLMAEKDSGPAGQP-EKPASQEVSTPSQARGEGSPSEATRLP 744

Query: 926 SAPVPSPA--PPPEAPRG 941
           +    S A  PP  +P G
Sbjct: 745 TQGARSSAAFPPKTSPGG 762



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 233/986 (23%), Positives = 315/986 (31%), Gaps = 275/986 (27%)

Query: 84   VQRLADEGPVQSPS----PHELQVLSPLSPLSPEPPGAPVPQPLQPGS------------ 127
            ++ L+    + SPS    P  +    PL+ L+P PP  P P P  P S            
Sbjct: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG 253

Query: 128  -------------------LRSPPDSEAYYGETDSDADGP-------------------- 148
                                 SPP S A   E    A GP                    
Sbjct: 254  GVTKWKSDVALNGRQAEATRASPPRSPA---EPKGSALGPNPEPHLTFPRSFKVPPPTPV 310

Query: 149  --------ATQEKPRRPR---RRGPTR-PTPPG---APPDEVYLS-----DSPAEPAPTI 188
                      QE PR+     ++ P+R P PP     P  +VY       D P E   T 
Sbjct: 311  RTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATA 370

Query: 189  PGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPL-RPGPHLIPMVGPVP------HP 241
            P  P  G S+    S  D  A  PPPA  L  P  PL  P P L P   P+P      HP
Sbjct: 371  PASPRLGQSQ----SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426

Query: 242  VAEDLTTTYTQKAKQAKLQ-------------------RAESLQEKSIKE-AKTKC--RT 279
             A     T T K+    L+                   R  S  EK   E A   C  R 
Sbjct: 427  PA---GFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483

Query: 280  IASLLTAAPNPH-SKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEE 338
                L+  P P  +      KK  +  +K TL+S  A      +   GVP  S       
Sbjct: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA-----KDTPPGVPEKSLGGSSLT 538

Query: 339  AFSDARSLTNQS----DWDSP---------YLDMELARAGSRASEGQGSGL-------GG 378
                A SLT  S      DSP          L+  L+ A  + ++     L       GG
Sbjct: 539  ETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGG 598

Query: 379  QLSEVSGRGVQLFEQQRQRADSSTQEL---ARVEPAAMLNGEGLQSPPRA---QSAPPEA 432
            ++ E      +L +   +     +  L     ++P AML   G   PP+A    + PP+A
Sbjct: 599  RICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAML---GPAIPPKATPEPAIPPKA 655

Query: 433  AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
             + P +P  A +    P +   G  TP       ++ P         PTTTS +   +A 
Sbjct: 656  TLWPATPPKATLGPATPLKATSGPTTP----LKATSGPAIASTATTLPTTTSQL---MAE 708

Query: 493  KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHA---PVSGSPST----PRSSGPVT 545
            K +     G +  P    S +  TP  +   G PS A   P  G+ S+    P++S    
Sbjct: 709  KDS-----GPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGG 763

Query: 546  ATSSLYIP------------------------APSRPVTPGGAPEPPAPPSAAAMT---- 577
                LY P                         P  PV     P  PA P A+A      
Sbjct: 764  EVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823

Query: 578  -------------STASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGIL 624
                         S  ++ L+A  R        A    +  P S R+      A+   I 
Sbjct: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIF 883

Query: 625  QEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEAC 684
                   +   + +  KE  K+SP            E P   G   G + +   L +   
Sbjct: 884  HSQGTPNSFTVVPKLPKEAEKDSP---------LTTEIPNKWGPRLGRDAEGTEL-SRRH 933

Query: 685  NFMQPVG---------ARSYKTLPHVTPK---TPPPMAPK-------------TPPPMTP 719
            N+ +P           A S     H  PK   +PP  + K              PPP   
Sbjct: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993

Query: 720  KTPPPVAP---------KPPSRGLLD--GLVN---GAASSAGIPEPP------------R 753
              P P AP          PP     D   L N   GA  + G    P            R
Sbjct: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053

Query: 754  LQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPS---PTPSLPPSWKYSPNIRAPPP 810
              G G  L  KR    + +   G P  G G    SP+   P P  P   + +   RAPP 
Sbjct: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPG 1113

Query: 811  IAYNPLLSPFFPQAARTLPKAQSQGP 836
              + P LS     AAR   +A+ + P
Sbjct: 1114 GLHAPRLS--LEGAARGAAEAKHKAP 1137



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 75/297 (25%), Positives = 103/297 (34%), Gaps = 53/297 (17%)

Query: 699 PHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGL-VNGAASSAGIPEPPRLQGR 757
           P  +P   PP     PPP+  + PPP +  PP   +L+ L      SS  IP PP     
Sbjct: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPP----- 212

Query: 758 GGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLP-PSWKYSPNIRAPPP------ 810
                         ++    P   L P P  P P P+ P P+  ++   R  PP      
Sbjct: 213 -------------DFIPPAPPLAFLAP-PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258

Query: 811 ---IAYN---PLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCF 864
              +A N      +   P  +   PK  + GP   P        F    P  ++T+    
Sbjct: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPV 317

Query: 865 DEVPPTPGPIASGSPKTARVQ-------EIRRFSTPAPQPTAEPLAPTVL------APRA 911
            E    P     G+ K A  +        IR  S   P    EP  P  L      +PR 
Sbjct: 318 QEAQEAPRK-EEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRL 376

Query: 912 ATTLDEPIWR--TELASAPVPSPA---PPPEAPRGLGASPSSCGFQVARPRFSATRT 963
             +  +   R  T   + P+P PA   PPP  P    A P  C  + A P    T+T
Sbjct: 377 GQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKT 433



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 54/187 (28%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P       P   +S  P G+P+P P  P +   PP          S A  P    +  
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSP--PSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197

Query: 156 RPRR--RGPTRPTPPG----APPDEVYLSDSPAEPAPTIPGP--PSQGDSRVSSP----S 203
            P      P+ PTPP     APP        P  PAP  P P  P    +R+  P     
Sbjct: 198 SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTK 257

Query: 204 WEDGAAL----------QPP--PAEALLLPHGPLRPGPHL-IPMVGPVPHPVAEDLTTTY 250
           W+   AL           PP  PAE      GP  P PHL  P    VP P     ++  
Sbjct: 258 WKSDVALNGRQAEATRASPPRSPAEPKGSALGP-NPEPHLTFPRSFKVPPPTPVRTSSIP 316

Query: 251 TQKAKQA 257
            Q+A++A
Sbjct: 317 VQEAQEA 323



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 128/548 (23%), Positives = 174/548 (31%), Gaps = 136/548 (24%)

Query: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523
           FN  +   T  L+ +      + F PL  +  N  L   +P+ P   + +  T   S  +
Sbjct: 58  FNTVSESGTATLKARPRVRPLLTFLPLNAQE-NHGLAVPTPSVPDDFADKEVTGTSSLVN 116

Query: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583
           G   +  +  S    R   P      L IP P     PG   +   PP  + + S  S  
Sbjct: 117 G---NLRLYSSVGDLR---PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPS-- 168

Query: 584 LSAPLRPSARPEAPAPGPGAPEPPSAREQRI----------------------------- 614
            +AP  P    E P P   AP PP   E                                
Sbjct: 169 -TAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP 227

Query: 615 --SVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGP 672
              VPA            GTR  +F PG      S     ++L     E  RA    S  
Sbjct: 228 PPPVPAPAPPAPASPHTVGTR--LFPPGGVTKWKSD----VALNGRQAEATRASPPRSPA 281

Query: 673 EEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPP-PVAPKPPS 731
           E    +LG                  P+  P    P + K PPP   +T   PV     +
Sbjct: 282 EPKGSALG------------------PNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 732 RGLLDGLVNGAASSAGIPEPPRLQGR-GGELFAKRQSRAD---RYVVEGTPGPGLG---- 783
               +G    A S   +P PP    R   +++  R    D            P LG    
Sbjct: 324 PRKEEGATKKAPSR--LPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQS 381

Query: 784 ---PRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQS-----QG 835
               R  +P P P LPP     P    PPP       +P  P AA  LP AQ       G
Sbjct: 382 QADERAGTPPPAPPLPP-----PAPPLPPP-------APPLPPAAPPLPCAQKAAHPPAG 429

Query: 836 PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSP----KTARVQEIR--- 888
              TPK    AL   + +P             PP+P   AS +P      ++++++R   
Sbjct: 430 FTKTPKSSSPAL---KPKPN------------PPSPENTASSAPVDWRDPSQMEKLRNEL 474

Query: 889 -----------RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPE 937
                      RF +  P PT   +AP     +    L E   +  L S P     PP  
Sbjct: 475 AAYLCGSRREDRFLSHRPGPT---VAPQSKEGKKGPRLPE---KETLLSLPA-KDTPPGV 527

Query: 938 APRGLGAS 945
             + LG S
Sbjct: 528 PEKSLGGS 535



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 98/421 (23%), Positives = 136/421 (32%), Gaps = 77/421 (18%)

Query: 28  RKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRL 87
           R P Q+ K+R    A   G R  D+           LSH                TV   
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRF----------LSHRPGP------------TVAPQ 499

Query: 88  ADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           + EG      P +  +LS   P    PPG  VP+    GS  S  ++EA    T    D 
Sbjct: 500 SKEGKKGPRLPEKETLLS--LPAKDTPPG--VPEKSLGGS--SLTETEAAPSLTLPSVDY 553

Query: 148 -PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPG----PPSQGDSRVSSP 202
            P     P   + R         A   E   S     P P + G         D ++S P
Sbjct: 554 IPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKP 613

Query: 203 SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGP--VPHPVAEDLTTTYTQKAKQAKLQ 260
                 A   PP    LLP   L+P   L P + P   P P      T +     +A L 
Sbjct: 614 -----VAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668

Query: 261 RAESLQEKSIKEAKTKCRT---IASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAA 317
            A  L+  S      K  +   IAS  T  P   S+  LM                    
Sbjct: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQ--LM-------------------- 706

Query: 318 GTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLG 377
              AE++ G     E    +E  + +++    S  ++  L  + AR+ S A   + S  G
Sbjct: 707 ---AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARS-SAAFPPKTSPGG 762

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPP 437
           G+        V    +      S ++E+A V P     G      P     PP     PP
Sbjct: 763 GE--------VPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814

Query: 438 S 438
           +
Sbjct: 815 A 815


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 107/395 (27%), Positives = 131/395 (33%), Gaps = 103/395 (26%)

Query: 436 PPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRA 495
           PP P PAP       +P GG+P P+P     S  P  P L                    
Sbjct: 141 PPPPGPAPGPPQDISEPPGGSPLPSPP----STAPPPPPLL------------------- 177

Query: 496 NDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAP 555
                 L P PPP   S  P P P   +  P H     SPS P     +     L   AP
Sbjct: 178 ------LEPPPPP---SMAPPPPPVLEALSPPH--TLSSPSIPTPPDFIPPAPPLAFLAP 226

Query: 556 SRPVTPGGAPEPPAPP------------------SAAAMTSTASIFLSAPLRPSARPEAP 597
             P  P  AP  PA P                    A     A    ++P R  A P+  
Sbjct: 227 PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGS 286

Query: 598 APGPGAPEPPSAREQRISVP---AARTGIL--QEARRRGTRKQMFRPGKEETKNSPNPEL 652
           A GP  PEP     +   VP     RT  +  QEA+          P KEE      P  
Sbjct: 287 ALGPN-PEPHLTFPRSFKVPPPTPVRTSSIPVQEAQE--------APRKEEGATKKAPSR 337

Query: 653 LSLVQNLDEKPRAG-GAESGPEEDAL-SLGAEACNFMQPVGARSYKTLPHVTPK--TPPP 708
           L L  +   +P +    +  PE D    L A A     P   R  ++      +  TPPP
Sbjct: 338 LPLPPSFHIRPASQVYPDRAPEPDCPGELKATA-----PASPRLGQSQSQADERAGTPPP 392

Query: 709 MAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSR 768
            AP  PPP  P  PPP  P PP+   L      A   AG  + P+               
Sbjct: 393 -APPLPPP-APPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK--------------- 435

Query: 769 ADRYVVEGTPGPGLGPRPRSPSP---TPSLPPSWK 800
                   +  P L P+P  PSP     S P  W+
Sbjct: 436 --------SSSPALKPKPNPPSPENTASSAPVDWR 462



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 155/618 (25%), Positives = 211/618 (34%), Gaps = 130/618 (21%)

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIF 464
           L  + P   L+   + +PP      P  A L P P P P  +P         P PA S  
Sbjct: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---------PAPA-SPH 243

Query: 465 NRSARPFTPG----------LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFL---- 510
               R F PG          L G++   T     P +P     S   L P P P L    
Sbjct: 244 TVGTRLFPPGGVTKWKSDVALNGRQAEATRA-SPPRSPAEPKGS--ALGPNPEPHLTFPR 300

Query: 511 SSQGPTPLPSFTSGVP----SHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPE 566
           S + P P P  TS +P      AP     +T ++   +    S +I  P+  V P  APE
Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RPASQVYPDRAPE 359

Query: 567 PPAPPSAAAMTSTASIFLS-------------APLRPSARPEAPAPGPGAPEPPSAREQR 613
           P  P    A T+ AS  L               P  P   P  P P P  P PP+A    
Sbjct: 360 PDCPGELKA-TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAP--- 415

Query: 614 ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPE 673
             +P A+      A    T K    P  +   N P+PE  +    +D +       S  E
Sbjct: 416 -PLPCAQKAAHPPAGFTKTPKSS-SPALKPKPNPPSPENTASSAPVDWRD-----PSQME 468

Query: 674 EDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP----PMAPK-----------TPPPMT 718
           +    L A  C   +     S++  P V P++      P  P+           TPP + 
Sbjct: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528

Query: 719 PKT----------------------PPPVAPKPPSRGL---LDGLVNGAASSAGIPE--- 750
            K+                       P  +P P  R +   L+  ++ AA     P    
Sbjct: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588

Query: 751 -PPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPP 809
            PP+ +  GG +    ++ AD   +       L P+  +  PT SL P     P I  PP
Sbjct: 589 LPPKPRLEGGRIC---ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAI--PP 643

Query: 810 PIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869
                P + P       T PKA + GP ATP                LK        +  
Sbjct: 644 KATPEPAIPPKATLWPATPPKA-TLGP-ATP----------------LKATSGPTTPLKA 685

Query: 870 TPGP----IASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELA 925
           T GP     A+  P T       + S PA QP  +P +  V  P  A     P   T L 
Sbjct: 686 TSGPAIASTATTLPTTTSQLMAEKDSGPAGQP-EKPASQEVSTPSQARGEGSPSEATRLP 744

Query: 926 SAPVPSPA--PPPEAPRG 941
           +    S A  PP  +P G
Sbjct: 745 TQGARSSAAFPPKTSPGG 762



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 233/986 (23%), Positives = 315/986 (31%), Gaps = 275/986 (27%)

Query: 84   VQRLADEGPVQSPS----PHELQVLSPLSPLSPEPPGAPVPQPLQPGS------------ 127
            ++ L+    + SPS    P  +    PL+ L+P PP  P P P  P S            
Sbjct: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG 253

Query: 128  -------------------LRSPPDSEAYYGETDSDADGP-------------------- 148
                                 SPP S A   E    A GP                    
Sbjct: 254  GVTKWKSDVALNGRQAEATRASPPRSPA---EPKGSALGPNPEPHLTFPRSFKVPPPTPV 310

Query: 149  --------ATQEKPRRPR---RRGPTR-PTPPG---APPDEVYLS-----DSPAEPAPTI 188
                      QE PR+     ++ P+R P PP     P  +VY       D P E   T 
Sbjct: 311  RTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATA 370

Query: 189  PGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPL-RPGPHLIPMVGPVP------HP 241
            P  P  G S+    S  D  A  PPPA  L  P  PL  P P L P   P+P      HP
Sbjct: 371  PASPRLGQSQ----SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426

Query: 242  VAEDLTTTYTQKAKQAKLQ-------------------RAESLQEKSIKE-AKTKC--RT 279
             A     T T K+    L+                   R  S  EK   E A   C  R 
Sbjct: 427  PA---GFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483

Query: 280  IASLLTAAPNPH-SKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEE 338
                L+  P P  +      KK  +  +K TL+S  A      +   GVP  S       
Sbjct: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA-----KDTPPGVPEKSLGGSSLT 538

Query: 339  AFSDARSLTNQS----DWDSP---------YLDMELARAGSRASEGQGSGL-------GG 378
                A SLT  S      DSP          L+  L+ A  + ++     L       GG
Sbjct: 539  ETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGG 598

Query: 379  QLSEVSGRGVQLFEQQRQRADSSTQEL---ARVEPAAMLNGEGLQSPPRA---QSAPPEA 432
            ++ E      +L +   +     +  L     ++P AML   G   PP+A    + PP+A
Sbjct: 599  RICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAML---GPAIPPKATPEPAIPPKA 655

Query: 433  AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
             + P +P  A +    P +   G  TP       ++ P         PTTTS +   +A 
Sbjct: 656  TLWPATPPKATLGPATPLKATSGPTTP----LKATSGPAIASTATTLPTTTSQL---MAE 708

Query: 493  KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHA---PVSGSPST----PRSSGPVT 545
            K +     G +  P    S +  TP  +   G PS A   P  G+ S+    P++S    
Sbjct: 709  KDS-----GPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGG 763

Query: 546  ATSSLYIP------------------------APSRPVTPGGAPEPPAPPSAAAMT---- 577
                LY P                         P  PV     P  PA P A+A      
Sbjct: 764  EVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823

Query: 578  -------------STASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGIL 624
                         S  ++ L+A  R        A    +  P S R+      A+   I 
Sbjct: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIF 883

Query: 625  QEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEAC 684
                   +   + +  KE  K+SP            E P   G   G + +   L +   
Sbjct: 884  HSQGTPNSFTVVPKLPKEAEKDSP---------LTTEIPNKWGPRLGRDAEGTEL-SRRH 933

Query: 685  NFMQPVG---------ARSYKTLPHVTPK---TPPPMAPK-------------TPPPMTP 719
            N+ +P           A S     H  PK   +PP  + K              PPP   
Sbjct: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993

Query: 720  KTPPPVAP---------KPPSRGLLD--GLVN---GAASSAGIPEPP------------R 753
              P P AP          PP     D   L N   GA  + G    P            R
Sbjct: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053

Query: 754  LQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPS---PTPSLPPSWKYSPNIRAPPP 810
              G G  L  KR    + +   G P  G G    SP+   P P  P   + +   RAPP 
Sbjct: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPG 1113

Query: 811  IAYNPLLSPFFPQAARTLPKAQSQGP 836
              + P LS     AAR   +A+ + P
Sbjct: 1114 GLHAPRLS--LEGAARGAAEAKHKAP 1137



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 75/297 (25%), Positives = 103/297 (34%), Gaps = 53/297 (17%)

Query: 699 PHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGL-VNGAASSAGIPEPPRLQGR 757
           P  +P   PP     PPP+  + PPP +  PP   +L+ L      SS  IP PP     
Sbjct: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPP----- 212

Query: 758 GGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLP-PSWKYSPNIRAPPP------ 810
                         ++    P   L P P  P P P+ P P+  ++   R  PP      
Sbjct: 213 -------------DFIPPAPPLAFLAP-PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258

Query: 811 ---IAYN---PLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCF 864
              +A N      +   P  +   PK  + GP   P        F    P  ++T+    
Sbjct: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPV 317

Query: 865 DEVPPTPGPIASGSPKTARVQ-------EIRRFSTPAPQPTAEPLAPTVL------APRA 911
            E    P     G+ K A  +        IR  S   P    EP  P  L      +PR 
Sbjct: 318 QEAQEAPRK-EEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRL 376

Query: 912 ATTLDEPIWR--TELASAPVPSPA---PPPEAPRGLGASPSSCGFQVARPRFSATRT 963
             +  +   R  T   + P+P PA   PPP  P    A P  C  + A P    T+T
Sbjct: 377 GQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKT 433



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 54/187 (28%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P       P   +S  P G+P+P P  P +   PP          S A  P    +  
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSP--PSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197

Query: 156 RPRR--RGPTRPTPPG----APPDEVYLSDSPAEPAPTIPGP--PSQGDSRVSSP----S 203
            P      P+ PTPP     APP        P  PAP  P P  P    +R+  P     
Sbjct: 198 SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTK 257

Query: 204 WEDGAAL----------QPP--PAEALLLPHGPLRPGPHL-IPMVGPVPHPVAEDLTTTY 250
           W+   AL           PP  PAE      GP  P PHL  P    VP P     ++  
Sbjct: 258 WKSDVALNGRQAEATRASPPRSPAEPKGSALGP-NPEPHLTFPRSFKVPPPTPVRTSSIP 316

Query: 251 TQKAKQA 257
            Q+A++A
Sbjct: 317 VQEAQEA 323



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 128/548 (23%), Positives = 174/548 (31%), Gaps = 136/548 (24%)

Query: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523
           FN  +   T  L+ +      + F PL  +  N  L   +P+ P   + +  T   S  +
Sbjct: 58  FNTVSESGTATLKARPRVRPLLTFLPLNAQE-NHGLAVPTPSVPDDFADKEVTGTSSLVN 116

Query: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583
           G   +  +  S    R   P      L IP P     PG   +   PP  + + S  S  
Sbjct: 117 G---NLRLYSSVGDLR---PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPS-- 168

Query: 584 LSAPLRPSARPEAPAPGPGAPEPPSAREQRI----------------------------- 614
            +AP  P    E P P   AP PP   E                                
Sbjct: 169 -TAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP 227

Query: 615 --SVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGP 672
              VPA            GTR  +F PG      S     ++L     E  RA    S  
Sbjct: 228 PPPVPAPAPPAPASPHTVGTR--LFPPGGVTKWKSD----VALNGRQAEATRASPPRSPA 281

Query: 673 EEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPP-PVAPKPPS 731
           E    +LG                  P+  P    P + K PPP   +T   PV     +
Sbjct: 282 EPKGSALG------------------PNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 732 RGLLDGLVNGAASSAGIPEPPRLQGR-GGELFAKRQSRAD---RYVVEGTPGPGLG---- 783
               +G    A S   +P PP    R   +++  R    D            P LG    
Sbjct: 324 PRKEEGATKKAPSR--LPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQS 381

Query: 784 ---PRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQS-----QG 835
               R  +P P P LPP     P    PPP       +P  P AA  LP AQ       G
Sbjct: 382 QADERAGTPPPAPPLPP-----PAPPLPPP-------APPLPPAAPPLPCAQKAAHPPAG 429

Query: 836 PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSP----KTARVQEIR--- 888
              TPK    AL   + +P             PP+P   AS +P      ++++++R   
Sbjct: 430 FTKTPKSSSPAL---KPKPN------------PPSPENTASSAPVDWRDPSQMEKLRNEL 474

Query: 889 -----------RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPE 937
                      RF +  P PT   +AP     +    L E   +  L S P     PP  
Sbjct: 475 AAYLCGSRREDRFLSHRPGPT---VAPQSKEGKKGPRLPE---KETLLSLPA-KDTPPGV 527

Query: 938 APRGLGAS 945
             + LG S
Sbjct: 528 PEKSLGGS 535



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 98/421 (23%), Positives = 136/421 (32%), Gaps = 77/421 (18%)

Query: 28  RKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRL 87
           R P Q+ K+R    A   G R  D+           LSH                TV   
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRF----------LSHRPGP------------TVAPQ 499

Query: 88  ADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           + EG      P +  +LS   P    PPG  VP+    GS  S  ++EA    T    D 
Sbjct: 500 SKEGKKGPRLPEKETLLS--LPAKDTPPG--VPEKSLGGS--SLTETEAAPSLTLPSVDY 553

Query: 148 -PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPG----PPSQGDSRVSSP 202
            P     P   + R         A   E   S     P P + G         D ++S P
Sbjct: 554 IPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKP 613

Query: 203 SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGP--VPHPVAEDLTTTYTQKAKQAKLQ 260
                 A   PP    LLP   L+P   L P + P   P P      T +     +A L 
Sbjct: 614 -----VAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668

Query: 261 RAESLQEKSIKEAKTKCRT---IASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAA 317
            A  L+  S      K  +   IAS  T  P   S+  LM                    
Sbjct: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQ--LM-------------------- 706

Query: 318 GTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLG 377
              AE++ G     E    +E  + +++    S  ++  L  + AR+ S A   + S  G
Sbjct: 707 ---AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARS-SAAFPPKTSPGG 762

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPP 437
           G+        V    +      S ++E+A V P     G      P     PP     PP
Sbjct: 763 GE--------VPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814

Query: 438 S 438
           +
Sbjct: 815 A 815


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 107/395 (27%), Positives = 131/395 (33%), Gaps = 103/395 (26%)

Query: 436 PPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRA 495
           PP P PAP       +P GG+P P+P     S  P  P L                    
Sbjct: 141 PPPPGPAPGPPQDISEPPGGSPLPSPP----STAPPPPPLL------------------- 177

Query: 496 NDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAP 555
                 L P PPP   S  P P P   +  P H     SPS P     +     L   AP
Sbjct: 178 ------LEPPPPP---SMAPPPPPVLEALSPPH--TLSSPSIPTPPDFIPPAPPLAFLAP 226

Query: 556 SRPVTPGGAPEPPAPP------------------SAAAMTSTASIFLSAPLRPSARPEAP 597
             P  P  AP  PA P                    A     A    ++P R  A P+  
Sbjct: 227 PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGS 286

Query: 598 APGPGAPEPPSAREQRISVP---AARTGIL--QEARRRGTRKQMFRPGKEETKNSPNPEL 652
           A GP  PEP     +   VP     RT  +  QEA+          P KEE      P  
Sbjct: 287 ALGPN-PEPHLTFPRSFKVPPPTPVRTSSIPVQEAQE--------APRKEEGATKKAPSR 337

Query: 653 LSLVQNLDEKPRAG-GAESGPEEDAL-SLGAEACNFMQPVGARSYKTLPHVTPK--TPPP 708
           L L  +   +P +    +  PE D    L A A     P   R  ++      +  TPPP
Sbjct: 338 LPLPPSFHIRPASQVYPDRAPEPDCPGELKATA-----PASPRLGQSQSQADERAGTPPP 392

Query: 709 MAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSR 768
            AP  PPP  P  PPP  P PP+   L      A   AG  + P+               
Sbjct: 393 -APPLPPP-APPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK--------------- 435

Query: 769 ADRYVVEGTPGPGLGPRPRSPSP---TPSLPPSWK 800
                   +  P L P+P  PSP     S P  W+
Sbjct: 436 --------SSSPALKPKPNPPSPENTASSAPVDWR 462



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 155/618 (25%), Positives = 211/618 (34%), Gaps = 130/618 (21%)

Query: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIF 464
           L  + P   L+   + +PP      P  A L P P P P  +P         P PA S  
Sbjct: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---------PAPA-SPH 243

Query: 465 NRSARPFTPG----------LQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFL---- 510
               R F PG          L G++   T     P +P     S   L P P P L    
Sbjct: 244 TVGTRLFPPGGVTKWKSDVALNGRQAEATRA-SPPRSPAEPKGS--ALGPNPEPHLTFPR 300

Query: 511 SSQGPTPLPSFTSGVP----SHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPE 566
           S + P P P  TS +P      AP     +T ++   +    S +I  P+  V P  APE
Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RPASQVYPDRAPE 359

Query: 567 PPAPPSAAAMTSTASIFLS-------------APLRPSARPEAPAPGPGAPEPPSAREQR 613
           P  P    A T+ AS  L               P  P   P  P P P  P PP+A    
Sbjct: 360 PDCPGELKA-TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAP--- 415

Query: 614 ISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPE 673
             +P A+      A    T K    P  +   N P+PE  +    +D +       S  E
Sbjct: 416 -PLPCAQKAAHPPAGFTKTPKSS-SPALKPKPNPPSPENTASSAPVDWRD-----PSQME 468

Query: 674 EDALSLGAEACNFMQPVGARSYKTLPHVTPKTPP----PMAPK-----------TPPPMT 718
           +    L A  C   +     S++  P V P++      P  P+           TPP + 
Sbjct: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528

Query: 719 PKT----------------------PPPVAPKPPSRGL---LDGLVNGAASSAGIPE--- 750
            K+                       P  +P P  R +   L+  ++ AA     P    
Sbjct: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588

Query: 751 -PPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPP 809
            PP+ +  GG +    ++ AD   +       L P+  +  PT SL P     P I  PP
Sbjct: 589 LPPKPRLEGGRIC---ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAI--PP 643

Query: 810 PIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869
                P + P       T PKA + GP ATP                LK        +  
Sbjct: 644 KATPEPAIPPKATLWPATPPKA-TLGP-ATP----------------LKATSGPTTPLKA 685

Query: 870 TPGP----IASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELA 925
           T GP     A+  P T       + S PA QP  +P +  V  P  A     P   T L 
Sbjct: 686 TSGPAIASTATTLPTTTSQLMAEKDSGPAGQP-EKPASQEVSTPSQARGEGSPSEATRLP 744

Query: 926 SAPVPSPA--PPPEAPRG 941
           +    S A  PP  +P G
Sbjct: 745 TQGARSSAAFPPKTSPGG 762



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 233/986 (23%), Positives = 315/986 (31%), Gaps = 275/986 (27%)

Query: 84   VQRLADEGPVQSPS----PHELQVLSPLSPLSPEPPGAPVPQPLQPGS------------ 127
            ++ L+    + SPS    P  +    PL+ L+P PP  P P P  P S            
Sbjct: 194  LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG 253

Query: 128  -------------------LRSPPDSEAYYGETDSDADGP-------------------- 148
                                 SPP S A   E    A GP                    
Sbjct: 254  GVTKWKSDVALNGRQAEATRASPPRSPA---EPKGSALGPNPEPHLTFPRSFKVPPPTPV 310

Query: 149  --------ATQEKPRRPR---RRGPTR-PTPPG---APPDEVYLS-----DSPAEPAPTI 188
                      QE PR+     ++ P+R P PP     P  +VY       D P E   T 
Sbjct: 311  RTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATA 370

Query: 189  PGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPL-RPGPHLIPMVGPVP------HP 241
            P  P  G S+    S  D  A  PPPA  L  P  PL  P P L P   P+P      HP
Sbjct: 371  PASPRLGQSQ----SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426

Query: 242  VAEDLTTTYTQKAKQAKLQ-------------------RAESLQEKSIKE-AKTKC--RT 279
             A     T T K+    L+                   R  S  EK   E A   C  R 
Sbjct: 427  PA---GFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483

Query: 280  IASLLTAAPNPH-SKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEE 338
                L+  P P  +      KK  +  +K TL+S  A      +   GVP  S       
Sbjct: 484  EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA-----KDTPPGVPEKSLGGSSLT 538

Query: 339  AFSDARSLTNQS----DWDSP---------YLDMELARAGSRASEGQGSGL-------GG 378
                A SLT  S      DSP          L+  L+ A  + ++     L       GG
Sbjct: 539  ETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGG 598

Query: 379  QLSEVSGRGVQLFEQQRQRADSSTQEL---ARVEPAAMLNGEGLQSPPRA---QSAPPEA 432
            ++ E      +L +   +     +  L     ++P AML   G   PP+A    + PP+A
Sbjct: 599  RICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAML---GPAIPPKATPEPAIPPKA 655

Query: 433  AVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492
             + P +P  A +    P +   G  TP       ++ P         PTTTS +   +A 
Sbjct: 656  TLWPATPPKATLGPATPLKATSGPTTP----LKATSGPAIASTATTLPTTTSQL---MAE 708

Query: 493  KRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHA---PVSGSPST----PRSSGPVT 545
            K +     G +  P    S +  TP  +   G PS A   P  G+ S+    P++S    
Sbjct: 709  KDS-----GPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGG 763

Query: 546  ATSSLYIP------------------------APSRPVTPGGAPEPPAPPSAAAMT---- 577
                LY P                         P  PV     P  PA P A+A      
Sbjct: 764  EVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823

Query: 578  -------------STASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGIL 624
                         S  ++ L+A  R        A    +  P S R+      A+   I 
Sbjct: 824  LRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIF 883

Query: 625  QEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEAC 684
                   +   + +  KE  K+SP            E P   G   G + +   L +   
Sbjct: 884  HSQGTPNSFTVVPKLPKEAEKDSP---------LTTEIPNKWGPRLGRDAEGTEL-SRRH 933

Query: 685  NFMQPVG---------ARSYKTLPHVTPK---TPPPMAPK-------------TPPPMTP 719
            N+ +P           A S     H  PK   +PP  + K              PPP   
Sbjct: 934  NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993

Query: 720  KTPPPVAP---------KPPSRGLLD--GLVN---GAASSAGIPEPP------------R 753
              P P AP          PP     D   L N   GA  + G    P            R
Sbjct: 994  NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053

Query: 754  LQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPS---PTPSLPPSWKYSPNIRAPPP 810
              G G  L  KR    + +   G P  G G    SP+   P P  P   + +   RAPP 
Sbjct: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPG 1113

Query: 811  IAYNPLLSPFFPQAARTLPKAQSQGP 836
              + P LS     AAR   +A+ + P
Sbjct: 1114 GLHAPRLS--LEGAARGAAEAKHKAP 1137



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 75/297 (25%), Positives = 103/297 (34%), Gaps = 53/297 (17%)

Query: 699 PHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGL-VNGAASSAGIPEPPRLQGR 757
           P  +P   PP     PPP+  + PPP +  PP   +L+ L      SS  IP PP     
Sbjct: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPP----- 212

Query: 758 GGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLP-PSWKYSPNIRAPPP------ 810
                         ++    P   L P P  P P P+ P P+  ++   R  PP      
Sbjct: 213 -------------DFIPPAPPLAFLAP-PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258

Query: 811 ---IAYN---PLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCF 864
              +A N      +   P  +   PK  + GP   P        F    P  ++T+    
Sbjct: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPV 317

Query: 865 DEVPPTPGPIASGSPKTARVQ-------EIRRFSTPAPQPTAEPLAPTVL------APRA 911
            E    P     G+ K A  +        IR  S   P    EP  P  L      +PR 
Sbjct: 318 QEAQEAPRK-EEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRL 376

Query: 912 ATTLDEPIWR--TELASAPVPSPA---PPPEAPRGLGASPSSCGFQVARPRFSATRT 963
             +  +   R  T   + P+P PA   PPP  P    A P  C  + A P    T+T
Sbjct: 377 GQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKT 433



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 54/187 (28%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 96  PSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPR 155
           P P       P   +S  P G+P+P P  P +   PP          S A  P    +  
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSP--PSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197

Query: 156 RPRR--RGPTRPTPPG----APPDEVYLSDSPAEPAPTIPGP--PSQGDSRVSSP----S 203
            P      P+ PTPP     APP        P  PAP  P P  P    +R+  P     
Sbjct: 198 SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTK 257

Query: 204 WEDGAAL----------QPP--PAEALLLPHGPLRPGPHL-IPMVGPVPHPVAEDLTTTY 250
           W+   AL           PP  PAE      GP  P PHL  P    VP P     ++  
Sbjct: 258 WKSDVALNGRQAEATRASPPRSPAEPKGSALGP-NPEPHLTFPRSFKVPPPTPVRTSSIP 316

Query: 251 TQKAKQA 257
            Q+A++A
Sbjct: 317 VQEAQEA 323



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 128/548 (23%), Positives = 174/548 (31%), Gaps = 136/548 (24%)

Query: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523
           FN  +   T  L+ +      + F PL  +  N  L   +P+ P   + +  T   S  +
Sbjct: 58  FNTVSESGTATLKARPRVRPLLTFLPLNAQE-NHGLAVPTPSVPDDFADKEVTGTSSLVN 116

Query: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583
           G   +  +  S    R   P      L IP P     PG   +   PP  + + S  S  
Sbjct: 117 G---NLRLYSSVGDLR---PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPS-- 168

Query: 584 LSAPLRPSARPEAPAPGPGAPEPPSAREQRI----------------------------- 614
            +AP  P    E P P   AP PP   E                                
Sbjct: 169 -TAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP 227

Query: 615 --SVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGP 672
              VPA            GTR  +F PG      S     ++L     E  RA    S  
Sbjct: 228 PPPVPAPAPPAPASPHTVGTR--LFPPGGVTKWKSD----VALNGRQAEATRASPPRSPA 281

Query: 673 EEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPP-PVAPKPPS 731
           E    +LG                  P+  P    P + K PPP   +T   PV     +
Sbjct: 282 EPKGSALG------------------PNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 732 RGLLDGLVNGAASSAGIPEPPRLQGR-GGELFAKRQSRAD---RYVVEGTPGPGLG---- 783
               +G    A S   +P PP    R   +++  R    D            P LG    
Sbjct: 324 PRKEEGATKKAPSR--LPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQS 381

Query: 784 ---PRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQS-----QG 835
               R  +P P P LPP     P    PPP       +P  P AA  LP AQ       G
Sbjct: 382 QADERAGTPPPAPPLPP-----PAPPLPPP-------APPLPPAAPPLPCAQKAAHPPAG 429

Query: 836 PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSP----KTARVQEIR--- 888
              TPK    AL   + +P             PP+P   AS +P      ++++++R   
Sbjct: 430 FTKTPKSSSPAL---KPKPN------------PPSPENTASSAPVDWRDPSQMEKLRNEL 474

Query: 889 -----------RFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPE 937
                      RF +  P PT   +AP     +    L E   +  L S P     PP  
Sbjct: 475 AAYLCGSRREDRFLSHRPGPT---VAPQSKEGKKGPRLPE---KETLLSLPA-KDTPPGV 527

Query: 938 APRGLGAS 945
             + LG S
Sbjct: 528 PEKSLGGS 535



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 98/421 (23%), Positives = 136/421 (32%), Gaps = 77/421 (18%)

Query: 28  RKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRL 87
           R P Q+ K+R    A   G R  D+           LSH                TV   
Sbjct: 462 RDPSQMEKLRNELAAYLCGSRREDRF----------LSHRPGP------------TVAPQ 499

Query: 88  ADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           + EG      P +  +LS   P    PPG  VP+    GS  S  ++EA    T    D 
Sbjct: 500 SKEGKKGPRLPEKETLLS--LPAKDTPPG--VPEKSLGGS--SLTETEAAPSLTLPSVDY 553

Query: 148 -PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPG----PPSQGDSRVSSP 202
            P     P   + R         A   E   S     P P + G         D ++S P
Sbjct: 554 IPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKP 613

Query: 203 SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGP--VPHPVAEDLTTTYTQKAKQAKLQ 260
                 A   PP    LLP   L+P   L P + P   P P      T +     +A L 
Sbjct: 614 -----VAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668

Query: 261 RAESLQEKSIKEAKTKCRT---IASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAA 317
            A  L+  S      K  +   IAS  T  P   S+  LM                    
Sbjct: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQ--LM-------------------- 706

Query: 318 GTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLG 377
              AE++ G     E    +E  + +++    S  ++  L  + AR+ S A   + S  G
Sbjct: 707 ---AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARS-SAAFPPKTSPGG 762

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPP 437
           G+        V    +      S ++E+A V P     G      P     PP     PP
Sbjct: 763 GE--------VPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814

Query: 438 S 438
           +
Sbjct: 815 A 815


>gi|118402590 myosin XV [Homo sapiens]
          Length = 3530

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 181/721 (25%), Positives = 232/721 (32%), Gaps = 158/721 (21%)

Query: 298  FKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYL 357
            F   RQR  +  L +FGA  G G   E G P      +   A S AR L        P  
Sbjct: 534  FLTPRQRNLQRALSAFGAHRGLGFGPEFGRP------VPRPATSLARFLKKTLSEKKPIA 587

Query: 358  DM---ELARAGSRASEGQ-----GSGLGGQLSEVSGRGVQLFEQQ---RQRADSSTQELA 406
             +   + ARAG  A         G  L G   E  G  + L   Q   R   D+      
Sbjct: 588  RLRGSQKARAGGPAVREAAYKRFGYKLAGMDPEKPGTPIVLRRAQPRARSSNDARRPPAP 647

Query: 407  RVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPL-PAPVASPRPFQPGGGAPTPAPSIFN 465
            +  P  + +   L SPP     PP +   P  PL PA    PRP  P G           
Sbjct: 648  QPAPRTLSHWSALLSPP-VPPRPPSSGPPPAPPLSPALSGLPRPASPYG----------- 695

Query: 466  RSARPFTPGLQGQRPTTTSVIFRPLAPKR---ANDSLGGLSPAPPPFLSSQGPTPLPSFT 522
                     L+   P   +    P AP+    A      +SP  PP L +  P P PSF 
Sbjct: 696  --------SLRRHPPPWAAPAHVPPAPQASWWAFVEPPAVSPEVPPDLLA-FPGPRPSFR 746

Query: 523  SGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPG-GAPEPPAPPSAAAMTSTAS 581
                  A      ++PR+S    A S L  P PS   +PG G   P APPS      T  
Sbjct: 747  GSRRRGAAFGFPGASPRASRR-RAWSPLASPQPSLRSSPGLGYCSPLAPPSPQLSLRTGP 805

Query: 582  I---FLSAPLRPSARPEAPAP--------GPGAPEPPSAREQRISVPAARTGILQEARRR 630
                FL    RP +  E+PAP         PG+P P S R      P+   G+    RR 
Sbjct: 806  FQPPFLPPARRPRSLQESPAPRRAAGRLGPPGSPLPGSPRP-----PSPPLGLCHSPRRS 860

Query: 631  GTRKQMFRPGKEETKNSPNPELLSLVQNLD-EKPRAGGAESGPEEDALSLGAEACNFMQP 689
                    P      + P    +     L   +P   GA   P E   S         +P
Sbjct: 861  SLNLPSRLPHTWRRLSEPPTRAVKPQVRLPFHRPPRAGAWRAPLEHRESP-------REP 913

Query: 690  VGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIP 749
              +         TP T PP+AP     M P   PP +P P   G       G +    +P
Sbjct: 914  EDSE--------TPWTVPPLAPSWDVDMPPTQRPP-SPWPGGAGSR----RGFSRPPPVP 960

Query: 750  EPPRLQGRG---GELFAKRQSRADRYVV----EGTPGPG-----LGPRPRSPS------- 790
            E P LQ  G             AD   V       PGPG      GP P  P        
Sbjct: 961  ENPFLQLLGPVPSPTLQPEDPAADMTRVFLGRHHEPGPGQLTKSAGPTPEKPEEEATLGD 1020

Query: 791  ---------PTPS-----LPPSWKYSPNIRAPPPIAYNPLLSPFFPQAA----------- 825
                     PTP+      PP     P    P      P LS  +P AA           
Sbjct: 1021 PQLPAETKPPTPAPPKDVTPPKDITPPKDVLPEQKTLRPSLS--YPLAACDQTRATWPPW 1078

Query: 826  ---RTLPKAQS-----QGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASG 877
                TLP+A +     + P   PK G                     +     PG  A  
Sbjct: 1079 HRWGTLPQAAAPLAPIRAPEPLPKGG---------------------ERRQAAPGRFAVV 1117

Query: 878  SPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPE 937
             P+  ++   +R      +P  +P+      PRA +     +W    A  P P     P+
Sbjct: 1118 MPRVQKLSSFQRVGPATLKPQVQPIQDP--KPRACSLRWSCLWLRADAYGPWPRVHTHPQ 1175

Query: 938  A 938
            +
Sbjct: 1176 S 1176



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 147/615 (23%), Positives = 203/615 (33%), Gaps = 158/615 (25%)

Query: 450  FQPGGGAPTPAPSI----FNRSA----RPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501
            F P  G P P P+     F +      +P       Q+        R  A KR    L G
Sbjct: 557  FGPEFGRPVPRPATSLARFLKKTLSEKKPIARLRGSQKARAGGPAVREAAYKRFGYKLAG 616

Query: 502  LSPAPP--PFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPV 559
            + P  P  P +  +     P   S   +  P +  P+ PR+    +A  S   P P RP 
Sbjct: 617  MDPEKPGTPIVLRRAQ---PRARSSNDARRPPAPQPA-PRTLSHWSALLSP--PVPPRPP 670

Query: 560  TPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAP--------EPPSARE 611
            + G  P PP  P+ + +   AS + S    P     APA  P AP        EPP+   
Sbjct: 671  SSGPPPAPPLSPALSGLPRPASPYGSLRRHPPPW-AAPAHVPPAPQASWWAFVEPPAVSP 729

Query: 612  Q----RISVPAARTGILQEARR-----------RGTRKQMFRPGKEETKNSPNPELLSLV 656
            +     ++ P  R       RR           R +R++ + P       SP P L S  
Sbjct: 730  EVPPDLLAFPGPRPSFRGSRRRGAAFGFPGASPRASRRRAWSP-----LASPQPSLRS-- 782

Query: 657  QNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGAR-SYKTLPHVTPKTPPPMAPK--- 712
                                 S G   C+ + P   + S +T P   P  PP   P+   
Sbjct: 783  ---------------------SPGLGYCSPLAPPSPQLSLRTGPFQPPFLPPARRPRSLQ 821

Query: 713  -TPPPM-------TPKTPPPVAPKPPSRGLLDGLVNG-AASSAGIP-----------EPP 752
             +P P         P +P P +P+PPS  L  GL +    SS  +P           EPP
Sbjct: 822  ESPAPRRAAGRLGPPGSPLPGSPRPPSPPL--GLCHSPRRSSLNLPSRLPHTWRRLSEPP 879

Query: 753  ------------RLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPS------PTPS 794
                            R G   A  + R      E +  P   P P +PS      PT  
Sbjct: 880  TRAVKPQVRLPFHRPPRAGAWRAPLEHRESPREPEDSETPWTVP-PLAPSWDVDMPPTQR 938

Query: 795  LPPSWKYSPNIR----APPPIAYNPLLSPFFPQAARTLPKAQSQGPRAT----------- 839
             P  W      R     PPP+  NP L    P  + TL   Q + P A            
Sbjct: 939  PPSPWPGGAGSRRGFSRPPPVPENPFLQLLGPVPSPTL---QPEDPAADMTRVFLGRHHE 995

Query: 840  --PKQGIKALDFMRHQPYQ---LKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPA 894
              P Q  K+      +P +   L       +  PPTP P    +P         +  TP 
Sbjct: 996  PGPGQLTKSAGPTPEKPEEEATLGDPQLPAETKPPTPAPPKDVTPP--------KDITPP 1047

Query: 895  PQ--PTAEPLAPTVLAPRAATTLDEPIW----------RTELASAPVPSPAPPPEAPRGL 942
                P  + L P++  P AA       W          +     AP+ +P P P+     
Sbjct: 1048 KDVLPEQKTLRPSLSYPLAACDQTRATWPPWHRWGTLPQAAAPLAPIRAPEPLPKGGERR 1107

Query: 943  GASPSSCGFQVARPR 957
             A+P    F V  PR
Sbjct: 1108 QAAPGR--FAVVMPR 1120



 Score = 33.9 bits (76), Expect = 0.76
 Identities = 37/135 (27%), Positives = 48/135 (35%), Gaps = 32/135 (23%)

Query: 110 LSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPG 169
           LS  P  A  PQ   P     PP + A+    +        +E PR P         PP 
Sbjct: 875 LSEPPTRAVKPQVRLP--FHRPPRAGAWRAPLEH-------RESPREPEDSETPWTVPPL 925

Query: 170 APPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGP 229
           AP  +V   D P    P  P P   G  R  S         +PPP     +P  P     
Sbjct: 926 APSWDV---DMPPTQRPPSPWPGGAGSRRGFS---------RPPP-----VPENP----- 963

Query: 230 HLIPMVGPVPHPVAE 244
             + ++GPVP P  +
Sbjct: 964 -FLQLLGPVPSPTLQ 977



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 56/212 (26%), Positives = 71/212 (33%), Gaps = 19/212 (8%)

Query: 92  PVQSPSPHELQVLSPL--SPLSPEPP--GAPVPQPLQPGSLRSPPDSEAYYGETDSDADG 147
           P   P+P  L   S L   P+ P PP  G P   PL P     P  +  Y          
Sbjct: 645 PAPQPAPRTLSHWSALLSPPVPPRPPSSGPPPAPPLSPALSGLPRPASPYGSLRRHPPPW 704

Query: 148 PATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDG 207
            A    P  P+        PP   P+     D  A P P    P  +G  R  +     G
Sbjct: 705 AAPAHVPPAPQASWWAFVEPPAVSPE--VPPDLLAFPGPR---PSFRGSRRRGAAFGFPG 759

Query: 208 AALQPPPAEA---LLLPHGPLRPGPHL---IPMVGPVPHPVAEDLTTTYTQKAKQAKLQR 261
           A+ +     A   L  P   LR  P L    P+  P P      L T   Q       +R
Sbjct: 760 ASPRASRRRAWSPLASPQPSLRSSPGLGYCSPLAPPSPQ---LSLRTGPFQPPFLPPARR 816

Query: 262 AESLQEK-SIKEAKTKCRTIASLLTAAPNPHS 292
             SLQE  + + A  +     S L  +P P S
Sbjct: 817 PRSLQESPAPRRAAGRLGPPGSPLPGSPRPPS 848



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 42/183 (22%), Positives = 62/183 (33%), Gaps = 30/183 (16%)

Query: 564  APEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI 623
            A +PPAP +      T        LR + +P APAP   AP  P         P A   +
Sbjct: 2490 AEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIK-------PVAAPVL 2542

Query: 624  LQEARRRGTRKQMFRPGKEETKNS-----PNPELLSLVQNLDEKPRAGGAES-------- 670
             Q+     T        +  T NS     P  ++ ++V+   +  R G  E+        
Sbjct: 2543 AQDQASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKV 2602

Query: 671  -----GPEEDALSLGAEACNFM-----QPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPK 720
                  P E+AL +       +       V   +   +  VT    P MAP +  P    
Sbjct: 2603 FMKRPDPHEEALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSL 2662

Query: 721  TPP 723
             PP
Sbjct: 2663 EPP 2665


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 138/585 (23%), Positives = 196/585 (33%), Gaps = 157/585 (26%)

Query: 378 GQLSEVSGRGVQLFEQQRQRADSSTQEL---ARVEPAAMLNGEGLQSPPRAQSAPPEAAV 434
           G+ S VS        Q R R  SS+ +    ++     + +G  L S   ++  P E++ 
Sbjct: 394 GRFSSVSS------PQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQP-ESST 446

Query: 435 LPPSPLPAPVASPRPFQPGGGAPTPAPSIFN-RSARPFTPGLQGQRPTTTSVIFRPLAPK 493
              S +P P        P GG+   A    + RS+     G    R  +   + RP  P 
Sbjct: 447 ASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSS-----GQLSGRSVSLRKLKRPPPPP 501

Query: 494 RANDSL---------GGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPV 544
           R   SL         G L   P P    Q   P P  T G    A  +  P  P +S   
Sbjct: 502 RRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEG-AGAAPCPPNPANS--- 557

Query: 545 TATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTA-SIFLSAPLRPSARPEAPAPGPGA 603
                 ++P     ++PGG+  PP  P      S+  S     P  P      P   PG 
Sbjct: 558 ------WVPG----LSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607

Query: 604 PEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNL--DE 661
            +PP                              +P +  +  SP   + S + +L    
Sbjct: 608 AQPP------------------------------KPERVTSLRSPGASVSSSLTSLCSSS 637

Query: 662 KPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKT 721
              A    SGP+             + P+G R +   PH  PK P   AP +PPP  P++
Sbjct: 638 SDPAPSDRSGPQ------------ILTPLGDR-FVIPPH--PKVP---APFSPPPSKPRS 679

Query: 722 PPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG 781
           P P AP   +  ++ G V  + + A    PP                        TP   
Sbjct: 680 PNPAAPALAAPAVVPGPV--STTDASPQSPP------------------------TPQTT 713

Query: 782 LGPRPRSP------SPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQG 835
           L P   SP      SP PS PPS  Y P    PPP    P +    P A+ T  +   Q 
Sbjct: 714 LTPLQESPVISKDQSPPPSPPPS--YHP----PPPPTKKPEVVVEAPSASET-AEEPLQD 766

Query: 836 PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASG-SPKTARVQEIRRFSTPA 894
           P   P                           PP P P     S       E   FS  +
Sbjct: 767 PNWPP---------------------------PPPPAPEEQDLSMADFPPPEEAFFSVAS 799

Query: 895 PQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAP 939
           P+P     +P +++  AA++      + +   +P P PAPP  AP
Sbjct: 800 PEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 104/440 (23%), Positives = 148/440 (33%), Gaps = 55/440 (12%)

Query: 429  PPEAAVLPP-SPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIF 487
            PP   V  P SP P+   SP P  P   AP   P   +      T     Q P T     
Sbjct: 661  PPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVS------TTDASPQSPPTPQTTL 714

Query: 488  RPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGS--------PSTPR 539
             PL             P+PPP   S  P P P+    V   AP +          P+ P 
Sbjct: 715  TPLQESPVISKDQSPPPSPPP---SYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPP 771

Query: 540  SSGPVTATSSLYI---PAPSR---------PVTPGGAPEPPAPPSAAAMTSTASIFLSAP 587
               P      L +   P P           P  P G+PE  + P+A++ ++TA       
Sbjct: 772  PPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATA-----LQ 826

Query: 588  LRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS 647
            ++P   P+ P P P AP P S+    ++        L +    G  K    P ++     
Sbjct: 827  IQPPGSPDPP-PAPPAPAPASSAPGHVAK-------LPQKEPVGCSKGGGPPREDVGAPL 878

Query: 648  PNPELLSLVQNLDEKPRAGGAES---GPEEDALSLGAEACNFMQPVGARSYKTLPHVTPK 704
              P LL +V+ L      GGA +   GP      L         PV A S      V  K
Sbjct: 879  VTPSLLQMVR-LRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLK 937

Query: 705  TPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAK 764
                 A +      P  PP   P+PP           + +S    +  R       +  +
Sbjct: 938  ACSLAASEGLSSAQPNGPPEAEPRPPQSP-------ASTASFIFSKGSRKLQLERPVSPE 990

Query: 765  RQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYN-PLLSPFFPQ 823
             Q+   R +V           P++P  +P  PP     P++  PPP + + P   P    
Sbjct: 991  TQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAP 1050

Query: 824  AARTLPKAQSQGPRATPKQG 843
                LP  Q +  R   + G
Sbjct: 1051 PTNGLPHTQDRTKRELAENG 1070



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 129/546 (23%), Positives = 183/546 (33%), Gaps = 95/546 (17%)

Query: 108  SPLSPEPPGAPVPQPLQPGSLRSP-------PDSEAYYGETDSD-------ADGPATQEK 153
            +P  P P  + VP     GS R P         S  Y  ++ +        A  PA+  K
Sbjct: 548  APCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607

Query: 154  PRRPRRRGPTRPTPPGAPPDE--VYLSDSPAEPAPTIPGPPS----QGDSRVSSPSWEDG 207
             + P+    T    PGA        L  S ++PAP+    P      GD  V  P  +  
Sbjct: 608  AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVP 667

Query: 208  AALQPPPAEALLLPHGPLRPGPHLIPMVGP--VPHPVAEDLTTTYTQKAKQAKLQRAESL 265
            A   PPP++       P  P P    +  P  VP PV+   TT  + ++          L
Sbjct: 668  APFSPPPSK-------PRSPNPAAPALAAPAVVPGPVS---TTDASPQSPPTPQTTLTPL 717

Query: 266  QEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEE-- 323
            QE  +         I+   +  P+P       +       KK  +V    +A   AEE  
Sbjct: 718  QESPV---------ISKDQSPPPSPPPS----YHPPPPPTKKPEVVVEAPSASETAEEPL 764

Query: 324  -EDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSE 382
             +   PP      +E+  S        +D+  P        A    +  + +G  G    
Sbjct: 765  QDPNWPPPPPPAPEEQDLS-------MADFPPP------EEAFFSVASPEPAGPSGSPEL 811

Query: 383  VSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPA 442
            VS             A SS+    +++P       G   PP A  AP  A+  P      
Sbjct: 812  VSS----------PAASSSSATALQIQP------PGSPDPPPAPPAPAPASSAPGHVAKL 855

Query: 443  PVASPRPFQPGG-------GAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRA 495
            P   P     GG       GAP   PS+  +  R  + G  G  PT       P  P R 
Sbjct: 856  PQKEPVGCSKGGGPPREDVGAPLVTPSLL-QMVRLRSVGAPGGAPTPALGPSAPQKPLRR 914

Query: 496  NDSLGGLSPAPPPFLSSQGPTPLP----SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLY 551
              S G  SP P P         L     + + G+ S  P     + PR      +T+S  
Sbjct: 915  ALS-GRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFI 973

Query: 552  IPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSARE 611
                SR +      E P  P   A      +     +     P+AP   P AP PP AR+
Sbjct: 974  FSKGSRKL----QLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAP-PPVARK 1028

Query: 612  QRISVP 617
              + VP
Sbjct: 1029 PSVGVP 1034



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 92/364 (25%), Positives = 124/364 (34%), Gaps = 93/364 (25%)

Query: 420  QSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQR 479
            QSPP  Q+       L  SP+ +   SP P  P    P P P+               ++
Sbjct: 705  QSPPTPQTT---LTPLQESPVISKDQSPPPSPPPSYHPPPPPT---------------KK 746

Query: 480  PTTTSVIFRPLAPKRANDSLGGLS--PAPPPFLSSQG------PTPLPSFTSGVPSHAPV 531
            P    V+  P A + A + L   +  P PPP    Q       P P  +F S V S  P 
Sbjct: 747  PEV--VVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS-VASPEPA 803

Query: 532  SGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTA----------- 580
              S S    S P  ++SS    A +  + P G+P+PP  P A A  S+A           
Sbjct: 804  GPSGSPELVSSPAASSSS----ATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKE 859

Query: 581  ----------------------SIFLSAPLRPSARP---EAPAPGPGAPEPPSARE---Q 612
                                  S+     LR    P     PA GP AP+ P  R    +
Sbjct: 860  PVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGR 919

Query: 613  RISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGP 672
               VPA  +G+    R +               N P PE          +PR   + +  
Sbjct: 920  ASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP-PEA---------EPRPPQSPAST 969

Query: 673  EEDALSLGAEACNFMQPVGARSYKTLPH-------VTPKTPPPMAPKTPPPMTPKTPPPV 725
                 S G+      +PV   +   L            +  PP APK     +PK PPPV
Sbjct: 970  ASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKK----SPKAPPPV 1025

Query: 726  APKP 729
            A KP
Sbjct: 1026 ARKP 1029



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 140/562 (24%), Positives = 187/562 (33%), Gaps = 100/562 (17%)

Query: 112  PEPPG-APVPQPLQPGSLRSPPDS-EAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPG 169
            P  PG A  P+P +  SLRSP  S  +      S +  PA  +      R GP   TP G
Sbjct: 602  PASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSD------RSGPQILTPLG 655

Query: 170  APPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGP 229
               D   +   P  PAP  P P     S+  SP+         P A AL  P   + PGP
Sbjct: 656  ---DRFVIPPHPKVPAPFSPPP-----SKPRSPN---------PAAPALAAP--AVVPGP 696

Query: 230  HLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPN 289
                   P   P  +   TT T             LQE  +         I+   +  P+
Sbjct: 697  VSTTDASPQSPPTPQ---TTLT------------PLQESPV---------ISKDQSPPPS 732

Query: 290  PHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEE------DGVPPTSESELD------- 336
            P       +       KK  +V    +A   AEE          PP +  E D       
Sbjct: 733  PPPS----YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP 788

Query: 337  --EEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQ 394
              EEAF    S        SP L    A + S A+  Q    G      +          
Sbjct: 789  PPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPA----PAP 844

Query: 395  RQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGG 454
               A     +L + EP     G G   PPR     P   ++ PS L   +   R     G
Sbjct: 845  ASSAPGHVAKLPQKEPVGCSKGGG---PPREDVGAP---LVTPSLL--QMVRLRSVGAPG 896

Query: 455  GAPTPA--PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPK----RANDSLGGLSPAPPP 508
            GAPTPA  PS   +  R    G     P  +S +   +  K     A++ L    P  PP
Sbjct: 897  GAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPP 956

Query: 509  FLS---SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
                   Q P    SF     S       P +P +   +       + + S    P  AP
Sbjct: 957  EAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQ-RPPQAP 1015

Query: 566  E--PPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGI 623
            +  P APP  A   S      ++P  P A P    P  G P      ++ +   A   G+
Sbjct: 1016 KKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKREL---AENGGV 1072

Query: 624  LQEARRRGTRKQMFRPGKEETK 645
            LQ     G  ++M  PG +  K
Sbjct: 1073 LQLV---GPEEKMGLPGSDSQK 1091



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 66/286 (23%), Positives = 101/286 (35%), Gaps = 44/286 (15%)

Query: 93   VQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGP---- 148
            V++PS  E     PL   +  PP  P P+         PP  EA++     +  GP    
Sbjct: 751  VEAPSASETAE-EPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSP 809

Query: 149  -------ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSS 201
                   A+       + + P  P PP APP     S +P   A  +P     G S+   
Sbjct: 810  ELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVA-KLPQKEPVGCSKGGG 868

Query: 202  PSWED-GAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQ 260
            P  ED GA L  P    ++       PG    P +GP                A Q  L+
Sbjct: 869  PPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGP---------------SAPQKPLR 913

Query: 261  RAESLQEKSIKEAKT---------KCRTIAS--LLTAAPNPHSKGVLMFKKRRQRAKKYT 309
            RA S +   +    +          C   AS  L +A PN    G    + R  ++   T
Sbjct: 914  RALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPN----GPPEAEPRPPQSPAST 969

Query: 310  LVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSP 355
                 +      + E  V P ++++L     ++ RS++ Q    +P
Sbjct: 970  ASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAP 1015



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 112/499 (22%), Positives = 160/499 (32%), Gaps = 113/499 (22%)

Query: 88   ADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQP------------GSLRSPPDSE 135
            +D  P     P   Q+L+PL      PP   VP P  P             +L +P    
Sbjct: 638  SDPAPSDRSGP---QILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVP 694

Query: 136  AYYGETDSDADGPATQEKPRRPRRRGPT---RPTPPGAPPDEVYLSDSPAEPAPTIPGPP 192
                 TD+    P T +    P +  P      +PP +PP   +    P +    +   P
Sbjct: 695  GPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAP 754

Query: 193  SQGDSR---VSSPSW-----------EDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPV 238
            S  ++    +  P+W           +   A  PPP EA      P   GP   P +  V
Sbjct: 755  SASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPEL--V 812

Query: 239  PHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMF 298
              P A   + T  Q            +Q     +              AP P S      
Sbjct: 813  SSPAASSSSATALQ------------IQPPGSPDPPP--------APPAPAPASSAPGHV 852

Query: 299  KKRRQRAKKYTLVSFGAAAGTGAEEED-GVPPTSESELDEEAFSDARSLTNQSDWDSPYL 357
             K  Q+         G + G G   ED G P  + S L        RS+       +P L
Sbjct: 853  AKLPQKE------PVGCSKGGGPPREDVGAPLVTPSLLQ---MVRLRSVGAPGGAPTPAL 903

Query: 358  DMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGE 417
                 +   R +      L G+ S V                S      R++  ++   E
Sbjct: 904  GPSAPQKPLRRA------LSGRASPVPA------------PSSGLHAAVRLKACSLAASE 945

Query: 418  GLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQG 477
            GL S     + PPEA   PP   PA  AS                IF++ +R     LQ 
Sbjct: 946  GLSS--AQPNGPPEAEPRPPQS-PASTAS---------------FIFSKGSRK----LQL 983

Query: 478  QRPT---TTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGS 534
            +RP    T + + R L  +     L  +S   PP    + P   P          P   S
Sbjct: 984  ERPVSPETQADLQRNLVAE-----LRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPAS 1038

Query: 535  PSTPRSSGPVTATSSLYIP 553
            PS PR+  P+TA  +  +P
Sbjct: 1039 PSYPRAE-PLTAPPTNGLP 1056



 Score = 33.5 bits (75), Expect = 1.00
 Identities = 70/299 (23%), Positives = 91/299 (30%), Gaps = 66/299 (22%)

Query: 87   LADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAY-----YGET 141
            L       S S   LQ+  P SP  P  P AP P    PG +   P  E        G  
Sbjct: 811  LVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPP 870

Query: 142  DSDADGP-ATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEP--------APTIPGPP 192
              D   P  T    +  R R       PG  P       +P +P        A  +P P 
Sbjct: 871  REDVGAPLVTPSLLQMVRLRS---VGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPS 927

Query: 193  S--------QGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRP----------GPHLIPM 234
            S        +  S  +S          PP AE    P  P  P          G   + +
Sbjct: 928  SGLHAAVRLKACSLAASEGLSSAQPNGPPEAE----PRPPQSPASTASFIFSKGSRKLQL 983

Query: 235  VGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCR--------------TI 280
              PV      DL      + +    QR     +KS K      R                
Sbjct: 984  ERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPR 1043

Query: 281  ASLLTAAPN---PHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPT-SESEL 335
            A  LTA P    PH+         + R K+    + G     G EE+ G+P + S+ EL
Sbjct: 1044 AEPLTAPPTNGLPHT---------QDRTKRELAENGGVLQLVGPEEKMGLPGSDSQKEL 1093


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 193/950 (20%), Positives = 283/950 (29%), Gaps = 124/950 (13%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
            P  +PSP      +P    +P PP    P P    +   PP +      T +    P T 
Sbjct: 1558 PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTT 1617

Query: 152  EKPRRPRRRGPTRPTPPGAPPDEVYLSDSP----AEPAPTIPGPPSQGDSRVSSPSWEDG 207
              P  P     T PT     P     S  P      P  T P PP+      ++PS    
Sbjct: 1618 PSP--PTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPT-----TTTPSPPIT 1670

Query: 208  AALQPPPAEALLLPHGPL--RPGPHLIPMVGPVPHPV-AEDLTTTYTQKAKQAKLQRAES 264
                PPP      P  P+   P P    M  P P    +  +TTT T  +         +
Sbjct: 1671 TTTTPPPTTT---PSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTT 1727

Query: 265  LQEKSIKEAKT---------KCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGA 315
            +   S     +            T +S LT  P P S     F            V    
Sbjct: 1728 MTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCN 1787

Query: 316  AAGTGAEEEDGVPPTSESELDEEAFSDARS---LTNQSDWDSPYLDMELARAGSRASEGQ 372
              G     + G P   +   D E   D        N S   + Y D+ + + G       
Sbjct: 1788 WTGW---LDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDV 1844

Query: 373  GSGLGGQLSEVSGRGV------QLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQ 426
              GL  +  +    GV        +E   Q  +  TQ      P  M         P   
Sbjct: 1845 SVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQ------PTTMTTTTTENPTPPTT 1898

Query: 427  SAPPEAAVLPPSPLP-------------APVASPRPFQPGGGAPTPAPSIFNRSARPFTP 473
            +       + P+P P                 +P P   G   PT  P     +  P   
Sbjct: 1899 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 1958

Query: 474  GLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSG 533
                Q PTTT +            +   ++P P P   +Q PT  P  T+   +  P   
Sbjct: 1959 PTGTQTPTTTPI-----------TTTTTVTPTPTP-TGTQTPTTTPITTTTTVTPTPTPT 2006

Query: 534  SPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSAR 593
               TP ++ P+T T+++  P P    TP G   P   P     T T +   +    P+  
Sbjct: 2007 GTQTPTTT-PITTTTTV-TPTP----TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2060

Query: 594  P------EAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNS 647
            P        P P P   + P+      +     T +       GT+     P    T  +
Sbjct: 2061 PITTTTTVTPTPTPTGTQTPTT-----TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2115

Query: 648  PNP----------ELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697
            P P            ++    +   P   G ++ P    ++          P G ++  T
Sbjct: 2116 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVTPTPTPTGTQTPTT 2174

Query: 698  LP-----HVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGI---P 749
             P      VTP TP P   +TP      T   V P P   G          ++  +   P
Sbjct: 2175 TPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2233

Query: 750  EPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIR-AP 808
             P   Q           +        GT  P   P   + + TP+  P+   +P      
Sbjct: 2234 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2293

Query: 809  PPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVP 868
                  P  +P   Q   T P   +     TP                  T +     V 
Sbjct: 2294 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--------TGTQTPTTTPITTTTTVT 2345

Query: 869  PTPGPIASGSPKTARVQEIRRFS-TPAP----QPTAEPL-APTVLAPRAATTLDEPIWRT 922
            PTP P  + +P T  +      + TP P     PT  P+   T + P    T  +    T
Sbjct: 2346 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2405

Query: 923  ELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 972
             + +    +P P P   +    +P +    V     + T TG Q     P
Sbjct: 2406 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTP 2452



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 99/444 (22%), Positives = 136/444 (30%), Gaps = 81/444 (18%)

Query: 503  SPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPG 562
            +P+PP    +  P+P P+ T+ +P     S  P+T  ++ P T T       PS P+T  
Sbjct: 1398 TPSPP----TTTPSPPPTSTTTLPPTTTPS-PPTTTTTTPPPTTT-------PSPPITTT 1445

Query: 563  GAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTG 622
              P P   PS    T+T     + P  P+  P  P   P  P   +      + P+  T 
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPT- 1504

Query: 623  ILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAE 682
                                 T  +P     +L       P      + P     S    
Sbjct: 1505 --------------------TTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTT 1544

Query: 683  ACNFMQPVGA-RSYKTLPHVTPKTPPPMAPKTPPPMTPKTPP-PVAPKPPSRGLLDGLVN 740
                  P+    S  TLP  T  +PPP    TPPP T  +PP    P PP+      +  
Sbjct: 1545 T-----PITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPT------ITT 1593

Query: 741  GAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWK 800
                    P PP                        TP P   P P  P+ TP  PP   
Sbjct: 1594 TTPPPTTTPSPPT-------------------TTTTTPPPTTTPSP--PTTTPITPP--- 1629

Query: 801  YSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTA 860
             +     PP    +P      P    T P   +  P  T              P    ++
Sbjct: 1630 -TSTTTLPPTTTPSPP-----PTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSS 1683

Query: 861  MFCFDEVPP-----TPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTL 915
                   PP     TP P  + S            +TP+P PT          P   TT 
Sbjct: 1684 PITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTT 1743

Query: 916  DEPIWRTELASAPVPSPAPPPEAP 939
               +  T  +S    +P PP   P
Sbjct: 1744 MTTLPPTTTSSPLTTTPLPPSITP 1767



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 80/315 (25%), Positives = 108/315 (34%), Gaps = 27/315 (8%)

Query: 422  PPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPT 481
            PP    +PP +    P P   P  SP    P     TP+P     +  P  P      PT
Sbjct: 1449 PPTTTPSPPISTTTTPPPTTTP--SPPTTTPSPPTTTPSPPTTTTTTPP--PTTTPSPPT 1504

Query: 482  TTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSS 541
            TT     P+ P  +  +L   +   PP  ++   TP P+ T   P+  P+  +P T  ++
Sbjct: 1505 TT-----PITPPASTTTLPPTTTPSPPTTTT--TTPPPTTTPSPPTTTPI--TPPTSTTT 1555

Query: 542  GPVTATSSLYIPAPSRPVTPGGAPEPPAP----PSAAAMTSTASIFLSAPLRPSARPEAP 597
             P T T S   P P+   TP     P  P    PS   +T+T     + P  P+     P
Sbjct: 1556 LPPTTTPS---PPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTP 1612

Query: 598  APGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQ 657
             P    P PP+     I+ P + T +               P    T + P     S   
Sbjct: 1613 PP-TTTPSPPTTTP--ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPI 1669

Query: 658  NLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPM 717
                 P      S P     S          P    S    P  T  TP      +PPP 
Sbjct: 1670 TTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPS---SPITTTTTPSSTTTPSPPPT 1726

Query: 718  TPKTP-PPVAPKPPS 731
            T  TP P   P PP+
Sbjct: 1727 TMTTPSPTTTPSPPT 1741



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 115/501 (22%), Positives = 146/501 (29%), Gaps = 116/501 (23%)

Query: 439  PLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDS 498
            P+   + +P P       PT  PS    S     P      PTTT+    P         
Sbjct: 1391 PMDKCITTPSP-------PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTT------- 1436

Query: 499  LGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRP 558
                +P+PP   ++   TP P+ T   P     +  P+T  S  P T T S     PS P
Sbjct: 1437 ----TPSPPITTTT---TPPPTTTPSPPISTTTTPPPTTTPS--PPTTTPSPPTTTPSPP 1487

Query: 559  VTPGGAPEP---PAPPSAAAMTSTASIFLSAPLRPSARPEAPA------PGPGAPEPPSA 609
             T    P P   P+PP+   +T  AS   +  L P+  P  P       P    P PP+ 
Sbjct: 1488 TTTTTTPPPTTTPSPPTTTPITPPAS---TTTLPPTTTPSPPTTTTTTPPPTTTPSPPTT 1544

Query: 610  REQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAE 669
                I+ P + T +               P    T + P     S        P      
Sbjct: 1545 TP--ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTP 1602

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKP 729
            S P                     +  T P  T  +PP   P TPP  T   PP   P P
Sbjct: 1603 SPP-------------------TTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP 1643

Query: 730  PSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSP 789
            P             ++   P P                         TP P     P  P
Sbjct: 1644 P------------PTTTTTPPPTT-----------------------TPSPPTTTTPSPP 1668

Query: 790  SPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDF 849
              T + PP     P      PI   P  SP  P    T P      P  TP         
Sbjct: 1669 ITTTTTPP-----PTTTPSSPITTTP--SP--PTTTMTTP-----SPTTTPS-------- 1706

Query: 850  MRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAP 909
                P    T         P P  + + SP T         +T  P  T+ PL  T L P
Sbjct: 1707 ---SPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPP 1763

Query: 910  RAATTLDEPIWRTELASAPVP 930
                    P   T   +  VP
Sbjct: 1764 SITPPTFSPFSTTTPTTPCVP 1784



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 96/410 (23%), Positives = 127/410 (30%), Gaps = 62/410 (15%)

Query: 436  PPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRA 495
            PP+  P+P  +     P    P+P  +         TP       TT      P  P   
Sbjct: 1401 PPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPIST 1460

Query: 496  NDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIP-- 553
              +    +   PP  +   PT  PS  +   +  P + +PS P ++      S+  +P  
Sbjct: 1461 TTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPT 1520

Query: 554  -APSRPVTPGGAPEP---PAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSA 609
              PS P T    P P   P+PP+   +T   S   +  L P+  P  P      P P + 
Sbjct: 1521 TTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS---TTTLPPTTTPSPPPTTTTTPPPTTT 1577

Query: 610  REQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAE 669
                 S P   T                 P    T   P     S        P      
Sbjct: 1578 P----SPPTTTTP---------------SPPTITTTTPPPTTTPSPPTTTTTTPPPTTTP 1618

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPP-PVAPK 728
            S P    ++               S  TLP  T  +PPP    TPPP T  +PP    P 
Sbjct: 1619 SPPTTTPIT------------PPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS 1666

Query: 729  PPSRGLLDGLVNGAASS--AGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRP 786
            PP             SS     P PP          +   + +       TP     P P
Sbjct: 1667 PPITTTTTPPPTTTPSSPITTTPSPPTTTMTTP---SPTTTPSSPITTTTTPSSTTTPSP 1723

Query: 787  -------RSPSPTPS--------LPPSWKYSPNIRAP-PPIAYNPLLSPF 820
                    SP+ TPS        LPP+   SP    P PP    P  SPF
Sbjct: 1724 PPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPF 1773



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 78/321 (24%), Positives = 107/321 (33%), Gaps = 51/321 (15%)

Query: 421  SPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP 480
            SPP   +  P     P  P   P+  P          TP+P     +  P  P      P
Sbjct: 1485 SPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPP--PTTTPSPP 1542

Query: 481  TTTSVIFRPLAPKRANDSL-GGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPR 539
            TTT     P+ P  +  +L    +P+PPP  ++   TP P+ T   PS  P + +PS P 
Sbjct: 1543 TTT-----PITPPTSTTTLPPTTTPSPPPTTTT---TPPPTTT---PS-PPTTTTPSPP- 1589

Query: 540  SSGPVTATSSLYIPAPSRPVTPGGAPEP---PAPPSAAAMTSTASIFLSAPLRPSARPEA 596
                +T T+      PS P T    P P   P+PP+   +T   S   +  L P+  P  
Sbjct: 1590 ---TITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS---TTTLPPTTTPSP 1643

Query: 597  P------APGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNP 650
            P       P    P PP+       +    T                 P    T +SP  
Sbjct: 1644 PPTTTTTPPPTTTPSPPTTTTPSPPITTTTT-----------------PPPTTTPSSPIT 1686

Query: 651  ELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMA 710
               S        P      S P     +  +       P    +  T    T  +PP   
Sbjct: 1687 TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPT---TMTTPSPTTTPSPPTTT 1743

Query: 711  PKTPPPMTPKTPPPVAPKPPS 731
              T PP T  +P    P PPS
Sbjct: 1744 MTTLPPTTTSSPLTTTPLPPS 1764



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 114/558 (20%), Positives = 174/558 (31%), Gaps = 67/558 (12%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P       Q PTTT +            +   ++P 
Sbjct: 2299 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT-----------TTTTVTPT 2347

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P P   +Q PT  P  T+   +  P      TP ++ P+T T+++  P P    TP G  
Sbjct: 2348 PTP-TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTV-TPTP----TPTGTQ 2400

Query: 566  EPPAPPSAAAMTSTASIFLSAPLRPSARP------EAPAPGPGAPEPPSAREQRISVPAA 619
             P   P     T T +   +    P+  P        P P P   + P+      +    
Sbjct: 2401 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT-----TPITT 2455

Query: 620  RTGILQEARRRGTRKQMFRPGKEETKNSPNP----------ELLSLVQNLDEKPRAGGAE 669
             T +       GT+     P    T  +P P            ++    +   P   G +
Sbjct: 2456 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2515

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLP-----HVTPKTPPPMAPKTPPPMTPKTPPP 724
            + P    ++          P G ++  T P      VTP TP P   +TP      T   
Sbjct: 2516 T-PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTT 2573

Query: 725  VAPKPPSRGLLDGLVNGAASSAGI---PEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG 781
            V P P   G          ++  +   P P   Q           +        GT  P 
Sbjct: 2574 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2633

Query: 782  LGPRPRSPSPTPSLPPSWKYSPNIR-APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840
              P   + + TP+  P+   +P            P  +P   Q   T P   +     TP
Sbjct: 2634 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2693

Query: 841  KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFS-TPAP---- 895
                              T +     V PTP P  + +P T  +      + TP P    
Sbjct: 2694 TP--------TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2745

Query: 896  QPTAEPL-APTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVA 954
             PT  P+   T + P    T  +    T + +    +P P P   +    +P +    V 
Sbjct: 2746 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2805

Query: 955  RPRFSATRTGLQAHVWRP 972
                + T TG Q     P
Sbjct: 2806 P---TPTPTGTQTPTTTP 2820



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 114/558 (20%), Positives = 174/558 (31%), Gaps = 67/558 (12%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P       Q PTTT +            +   ++P 
Sbjct: 2736 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT-----------TTTTVTPT 2784

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P P   +Q PT  P  T+   +  P      TP ++ P+T T+++  P P    TP G  
Sbjct: 2785 PTP-TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTV-TPTP----TPTGTQ 2837

Query: 566  EPPAPPSAAAMTSTASIFLSAPLRPSARP------EAPAPGPGAPEPPSAREQRISVPAA 619
             P   P     T T +   +    P+  P        P P P   + P+      +    
Sbjct: 2838 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT-----TPITT 2892

Query: 620  RTGILQEARRRGTRKQMFRPGKEETKNSPNP----------ELLSLVQNLDEKPRAGGAE 669
             T +       GT+     P    T  +P P            ++    +   P   G +
Sbjct: 2893 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2952

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLP-----HVTPKTPPPMAPKTPPPMTPKTPPP 724
            + P    ++          P G ++  T P      VTP TP P   +TP      T   
Sbjct: 2953 T-PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTT 3010

Query: 725  VAPKPPSRGLLDGLVNGAASSAGI---PEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG 781
            V P P   G          ++  +   P P   Q           +        GT  P 
Sbjct: 3011 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3070

Query: 782  LGPRPRSPSPTPSLPPSWKYSPNIR-APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840
              P   + + TP+  P+   +P            P  +P   Q   T P   +     TP
Sbjct: 3071 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3130

Query: 841  KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFS-TPAP---- 895
                              T +     V PTP P  + +P T  +      + TP P    
Sbjct: 3131 TP--------TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3182

Query: 896  QPTAEPL-APTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVA 954
             PT  P+   T + P    T  +    T + +    +P P P   +    +P +    V 
Sbjct: 3183 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3242

Query: 955  RPRFSATRTGLQAHVWRP 972
                + T TG Q     P
Sbjct: 3243 P---TPTPTGTQTPTTTP 3257



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 114/558 (20%), Positives = 174/558 (31%), Gaps = 67/558 (12%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P       Q PTTT +            +   ++P 
Sbjct: 3173 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT-----------TTTTVTPT 3221

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P P   +Q PT  P  T+   +  P      TP ++ P+T T+++  P P    TP G  
Sbjct: 3222 PTP-TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTV-TPTP----TPTGTQ 3274

Query: 566  EPPAPPSAAAMTSTASIFLSAPLRPSARP------EAPAPGPGAPEPPSAREQRISVPAA 619
             P   P     T T +   +    P+  P        P P P   + P+      +    
Sbjct: 3275 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT-----TPITT 3329

Query: 620  RTGILQEARRRGTRKQMFRPGKEETKNSPNP----------ELLSLVQNLDEKPRAGGAE 669
             T +       GT+     P    T  +P P            ++    +   P   G +
Sbjct: 3330 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3389

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLP-----HVTPKTPPPMAPKTPPPMTPKTPPP 724
            + P    ++          P G ++  T P      VTP TP P   +TP      T   
Sbjct: 3390 T-PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTT 3447

Query: 725  VAPKPPSRGLLDGLVNGAASSAGI---PEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG 781
            V P P   G          ++  +   P P   Q           +        GT  P 
Sbjct: 3448 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3507

Query: 782  LGPRPRSPSPTPSLPPSWKYSPNIR-APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840
              P   + + TP+  P+   +P            P  +P   Q   T P   +     TP
Sbjct: 3508 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3567

Query: 841  KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFS-TPAP---- 895
                              T +     V PTP P  + +P T  +      + TP P    
Sbjct: 3568 TP--------TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3619

Query: 896  QPTAEPL-APTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVA 954
             PT  P+   T + P    T  +    T + +    +P P P   +    +P +    V 
Sbjct: 3620 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 3679

Query: 955  RPRFSATRTGLQAHVWRP 972
                + T TG Q     P
Sbjct: 3680 P---TPTPTGTQTPTTTP 3694



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 114/558 (20%), Positives = 174/558 (31%), Gaps = 67/558 (12%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P       Q PTTT +            +   ++P 
Sbjct: 3610 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT-----------TTTTVTPT 3658

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P P   +Q PT  P  T+   +  P      TP ++ P+T T+++  P P    TP G  
Sbjct: 3659 PTP-TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTV-TPTP----TPTGTQ 3711

Query: 566  EPPAPPSAAAMTSTASIFLSAPLRPSARP------EAPAPGPGAPEPPSAREQRISVPAA 619
             P   P     T T +   +    P+  P        P P P   + P+      +    
Sbjct: 3712 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT-----TPITT 3766

Query: 620  RTGILQEARRRGTRKQMFRPGKEETKNSPNP----------ELLSLVQNLDEKPRAGGAE 669
             T +       GT+     P    T  +P P            ++    +   P   G +
Sbjct: 3767 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3826

Query: 670  SGPEEDALSLGAEACNFMQPVGARSYKTLP-----HVTPKTPPPMAPKTPPPMTPKTPPP 724
            + P    ++          P G ++  T P      VTP TP P   +TP      T   
Sbjct: 3827 T-PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTT 3884

Query: 725  VAPKPPSRGLLDGLVNGAASSAGI---PEPPRLQGRGGELFAKRQSRADRYVVEGTPGPG 781
            V P P   G          ++  +   P P   Q           +        GT  P 
Sbjct: 3885 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3944

Query: 782  LGPRPRSPSPTPSLPPSWKYSPNIR-APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATP 840
              P   + + TP+  P+   +P            P  +P   Q   T P   +     TP
Sbjct: 3945 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 4004

Query: 841  KQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFS-TPAP---- 895
                              T +     V PTP P  + +P T  +      + TP P    
Sbjct: 4005 TP--------TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4056

Query: 896  QPTAEPL-APTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVA 954
             PT  P+   T + P    T  +    T + +    +P P P   +    +P +    V 
Sbjct: 4057 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4116

Query: 955  RPRFSATRTGLQAHVWRP 972
                + T TG Q     P
Sbjct: 4117 P---TPTPTGTQTPTTTP 4131



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 70/289 (24%), Positives = 87/289 (30%), Gaps = 63/289 (21%)

Query: 699  PHVTPKTPPPMAPKTPPPMTPKTPPPVA-PKPP-SRGLLDGLVNGAASSAGIPEPPRLQG 756
            P  T  TPPP    +PP  T  TPPP   P PP S           +     P PP    
Sbjct: 1425 PTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTT-- 1482

Query: 757  RGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSP------TPSLPPSWKYSP---NIRA 807
                      + +       TP P   P P + +P      T +LPP+   SP       
Sbjct: 1483 ----------TPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTT 1532

Query: 808  PPPIAYN--PLLSPFFPQAART-LPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCF 864
            PPP      P  +P  P  + T LP   +  P  T                         
Sbjct: 1533 PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPT------------------------- 1567

Query: 865  DEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVL----------APRAATT 914
                 TP P  + SP T         +T  P PT  P  PT            +P   T 
Sbjct: 1568 --TTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625

Query: 915  LDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRT 963
            +  P   T L     PSP P          +PS        P  + T T
Sbjct: 1626 ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTT 1674



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 63/246 (25%), Positives = 79/246 (32%), Gaps = 23/246 (9%)

Query: 701  VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGE 760
            +T  +PP   P  PP  T   PP   P PP+                 P PP        
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPT------TTTTTPPPTTTPSPPITTTTTP- 1448

Query: 761  LFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSP---NIRAPPPIA--YNP 815
                  + +       TP P   P P  P+ TPS PP+   SP       PPP      P
Sbjct: 1449 --PPTTTPSPPISTTTTPPPTTTPSP--PTTTPS-PPTTTPSPPTTTTTTPPPTTTPSPP 1503

Query: 816  LLSPFFPQAA-RTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPI 874
              +P  P A+  TLP   +  P  T                   T       +PPT  P 
Sbjct: 1504 TTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP- 1562

Query: 875  ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPR-AATTLDEPIWRTELASAPVPSPA 933
               SP           +TP+P  T  P  PT+       TT   P   T     P  +P+
Sbjct: 1563 ---SPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPS 1619

Query: 934  PPPEAP 939
            PP   P
Sbjct: 1620 PPTTTP 1625



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 83/395 (21%), Positives = 128/395 (32%), Gaps = 42/395 (10%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P       Q PTTT +            +   ++P 
Sbjct: 3909 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT-----------TTTTVTPT 3957

Query: 506  PPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAP 565
            P P   +Q PT  P  T+   +  P      TP ++ P+T T+++  P P    TP G  
Sbjct: 3958 PTP-TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTV-TPTP----TPTGTQ 4010

Query: 566  EPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVP-AARTGIL 624
             P   P     T T +   +    P+  P            P+  +   + P    T + 
Sbjct: 4011 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4070

Query: 625  QEARRRGTRKQMFRPGKEETKNSPNPEL----------LSLVQNLDEKPRAGGAESGPEE 674
                  GT+     P    T  +P P            ++    +   P   G ++ P  
Sbjct: 4071 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTT 4129

Query: 675  DALSLGAEACNFMQPVGARSYKTLP-----HVTPKTPPPMAPKTPPPMTPKTPPPVAPKP 729
              ++          P G ++  T P      VTP TP P   +TP      T   V P P
Sbjct: 4130 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTP 4188

Query: 730  PSRGLLDGLVNGAASSAGIPE-----PPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGP 784
               G   G      S+A I E     PP          +      +   +  T  P +  
Sbjct: 4189 TPTGTQTGPPT-HTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEM 4247

Query: 785  RPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSP 819
               +P  TP+ P +      +  PP    +P  +P
Sbjct: 4248 TSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTP 4282



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 78/313 (24%), Positives = 113/313 (36%), Gaps = 46/313 (14%)

Query: 446  SPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPA 505
            +P P   G   PT  P     +  P TP   G +  TT+ I             G  +P 
Sbjct: 4116 TPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 4174

Query: 506  PPPFLSSQGPTPLPSFT---SGVPSHA--------------PVSGSPSTPRS-SGPVTAT 547
              P  ++   TP P+ T   +G P+H               P S +P T RS S P+T +
Sbjct: 4175 TTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTES 4234

Query: 548  SSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGP--GAPE 605
            ++L    P  P     +  PP+ P+A   TS        P   ++ P  P  G   G+  
Sbjct: 4235 TTLLSTLP--PAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSS 4292

Query: 606  PPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKN-SPNPELLSLVQNLDEKPR 664
             P+    + +  +A T          T   +  P    T    P P  + +   L++   
Sbjct: 4293 APTPSTVQTTTTSAWTP---------TPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYY 4343

Query: 665  AGGAE--SGPEED-------ALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK-TP 714
            A G E  +G   D       +LS   E  N+  P    +    P  +  TP P  P  TP
Sbjct: 4344 APGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCP---STPSPTPTPSKSTPTPSKPSSTP 4400

Query: 715  PPMTPKTPPPVAP 727
               TP T PP  P
Sbjct: 4401 SKPTPGTKPPECP 4413



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 59/242 (24%), Positives = 79/242 (32%), Gaps = 72/242 (29%)

Query: 421  SPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRP 480
            +P   Q+ PP           AP+A      P   + TP  S    S    +  L    P
Sbjct: 4189 TPTGTQTGPPTHTST------APIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLP 4242

Query: 481  -----TTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSP 535
                 T+T+    P AP   +   GG + +PPP  ++  P        G P+    +GS 
Sbjct: 4243 PAIEMTSTAPPSTPTAPTTTS---GGHTLSPPPSTTTSPP--------GTPTRGTTTGSS 4291

Query: 536  STPRSSGPVTATSSLYIPAPSRPVTP------GGAPEPP-------------AP------ 570
            S P  S   T T+S + P P+   TP      G  P P              AP      
Sbjct: 4292 SAPTPSTVQTTTTSAWTPTPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYN 4351

Query: 571  -------------------------PSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPE 605
                                     PS  + T T S     P +PS+ P  P PG   PE
Sbjct: 4352 GTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPPE 4411

Query: 606  PP 607
             P
Sbjct: 4412 CP 4413



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 39/163 (23%), Positives = 53/163 (32%), Gaps = 17/163 (10%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPP------GAPVPQPLQPGSLRSPPDSEAYYGETDSDA 145
            P  +PSP      +P    +P PP        P   P  P +  SPP +      T +  
Sbjct: 1434 PTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTT 1493

Query: 146  DGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWE 205
              P T   P        T P  P A    +  + +P+ P  T   PP       ++PS  
Sbjct: 1494 PPPTTTPSP------PTTTPITPPASTTTLPPTTTPSPPTTTTTTPPP-----TTTPSPP 1542

Query: 206  DGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTT 248
                + PP +   L P     P P       P   P     TT
Sbjct: 1543 TTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1585



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 41/170 (24%), Positives = 56/170 (32%), Gaps = 14/170 (8%)

Query: 92   PVQSPSPHELQVLSP------LSPLS-PEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSD 144
            P  +PSP     ++P      L P + P PP      P  P +  SPP +      T + 
Sbjct: 1496 PTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTP-PPTTTPSPPTTTPITPPTSTT 1554

Query: 145  ADGPATQEKPRRPRRRGP---TRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSR--- 198
               P T   P       P   T P+PP           +   P  T P PP+   +    
Sbjct: 1555 TLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPP 1614

Query: 199  VSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTT 248
             ++PS      + PP +   L P     P P       P   P     TT
Sbjct: 1615 TTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1664



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 3/81 (3%)

Query: 869  PTPGPIASGS--PKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELAS 926
            P+P P ++ +  P T         +TP P  T  P   T   P   TT   PI  T    
Sbjct: 1406 PSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPI-STTTTP 1464

Query: 927  APVPSPAPPPEAPRGLGASPS 947
             P  +P+PP   P     +PS
Sbjct: 1465 PPTTTPSPPTTTPSPPTTTPS 1485



 Score = 35.0 bits (79), Expect = 0.34
 Identities = 36/141 (25%), Positives = 47/141 (33%), Gaps = 9/141 (6%)

Query: 111  SPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGA 170
            +P PP    P P    +   PP +      T +    P T   P       P   T P  
Sbjct: 1398 TPSPP-TTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSP 1456

Query: 171  PPDEVYLSDSPAEPAPTIPGPPSQGDS-RVSSPSWEDGAALQPPPAEALLLP-HGPLRPG 228
            P     +S +   P  T P PP+   S   ++PS        PPP      P   P+ P 
Sbjct: 1457 P-----ISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP- 1510

Query: 229  PHLIPMVGPVPHPVAEDLTTT 249
            P     + P   P     TTT
Sbjct: 1511 PASTTTLPPTTTPSPPTTTTT 1531



 Score = 35.0 bits (79), Expect = 0.34
 Identities = 39/158 (24%), Positives = 52/158 (32%), Gaps = 30/158 (18%)

Query: 92   PVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQ 151
            P  +PSP      +P    +P PP      P  P +  SPP S        +    P T 
Sbjct: 1418 PTTTPSPPTTTTTTPPPTTTPSPPITTTTTP-PPTTTPSPPIST-------TTTPPPTTT 1469

Query: 152  EKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQ 211
              P        T P+PP         + +P+ P  T   PP       ++PS      + 
Sbjct: 1470 PSPPT------TTPSPP---------TTTPSPPTTTTTTPPP-----TTTPSPPTTTPIT 1509

Query: 212  PPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTT 249
            PP +   L P     P P       P P       TTT
Sbjct: 1510 PPASTTTLPP--TTTPSPPTTTTTTPPPTTTPSPPTTT 1545


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.130    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,922,473
Number of Sequences: 37866
Number of extensions: 4388463
Number of successful extensions: 74432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 2471
Number of HSP's that attempted gapping in prelim test: 24453
Number of HSP's gapped (non-prelim): 28961
length of query: 977
length of database: 18,247,518
effective HSP length: 112
effective length of query: 865
effective length of database: 14,006,526
effective search space: 12115644990
effective search space used: 12115644990
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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