Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 153085395
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153085395 histone deacetylase 4 [Homo sapiens]
(1084 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153085395 histone deacetylase 4 [Homo sapiens] 2164 0.0
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 1207 0.0
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 1204 0.0
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 1143 0.0
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 1134 0.0
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1096 0.0
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 875 0.0
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 840 0.0
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 806 0.0
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 493 e-139
gi|13128864 histone deacetylase 6 [Homo sapiens] 301 2e-81
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 238 3e-62
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 207 3e-53
gi|8923769 histone deacetylase 8 [Homo sapiens] 107 5e-23
gi|13128860 histone deacetylase 1 [Homo sapiens] 104 5e-22
gi|116284376 histone deacetylase 2 [Homo sapiens] 103 9e-22
gi|13128862 histone deacetylase 3 [Homo sapiens] 87 1e-16
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 62 3e-09
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 61 7e-09
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 59 2e-08
gi|221139761 zinc finger protein 853 [Homo sapiens] 58 4e-08
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 58 6e-08
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 56 2e-07
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 56 2e-07
gi|149999352 forkhead box P2 isoform II [Homo sapiens] 56 2e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 56 2e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 55 5e-07
gi|22538413 forkhead box P2 isoform III [Homo sapiens] 54 6e-07
gi|226246533 TOX high mobility group box family member 3 isoform... 54 6e-07
gi|226054295 TOX high mobility group box family member 3 isoform... 54 6e-07
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 2164 bits (5606), Expect = 0.0
Identities = 1084/1084 (100%), Positives = 1084/1084 (100%)
Query: 1 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 60
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
Sbjct: 1 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 60
Query: 61 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 120
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
Sbjct: 61 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 120
Query: 121 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 180
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
Sbjct: 121 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 180
Query: 181 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 240
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
Sbjct: 181 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 240
Query: 241 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 300
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
Sbjct: 241 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 300
Query: 301 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 360
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
Sbjct: 301 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 360
Query: 361 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 420
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
Sbjct: 361 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 420
Query: 421 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL 480
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
Sbjct: 421 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL 480
Query: 481 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY 540
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
Sbjct: 481 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY 540
Query: 541 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 600
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
Sbjct: 541 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 600
Query: 601 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT 660
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
Sbjct: 601 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT 660
Query: 661 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT 720
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
Sbjct: 661 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT 720
Query: 721 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE 780
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
Sbjct: 721 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE 780
Query: 781 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD 840
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
Sbjct: 781 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD 840
Query: 841 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP 900
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
Sbjct: 841 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP 900
Query: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
Sbjct: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960
Query: 961 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV 1020
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
Sbjct: 961 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV 1020
Query: 1021 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE 1080
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
Sbjct: 1021 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE 1080
Query: 1081 EPPL 1084
EPPL
Sbjct: 1081 EPPL 1084
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 1207 bits (3123), Expect = 0.0
Identities = 668/1150 (58%), Positives = 821/1150 (71%), Gaps = 94/1150 (8%)
Query: 1 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAV---------PMDL 51
M+S + DG+SGR+ +E+L ++ +P TV+V LP + PS++ P++L
Sbjct: 1 MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLP-RAMPSSMGGGGGGSPSPVEL 59
Query: 52 RLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEH 111
R S+ +P LREQQLQQELLALKQ+QQ+Q+Q+L AEFQ+QH+ L+RQHE QL +H
Sbjct: 60 RGALVGSV---DPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKH 116
Query: 112 IKQQQEMLAMKHQQELL--------EHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE 163
+KQQQEMLA K QQE+L E QR+ E+ RQE ELEKQ EQ+L L+NKEK KE
Sbjct: 117 LKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQE-ELEKQRLEQQLLILRNKEKSKE 175
Query: 164 SAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSG--- 220
SA+ASTEVK++LQEF+L+K K LNH + P+ W H+SLDQSSPPQSG
Sbjct: 176 SAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPG 233
Query: 221 VSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTAL 280
SY P+ G YD++DDFPLRKTASEPNLK+RSRLKQKVAERRSSPLLRRKDG V++
Sbjct: 234 TPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTF 293
Query: 281 KKRPLDVT------DSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLV 334
KKR +++T S C+SAPGSGPSSPN+S ++ AENG +VP+IP E HR +
Sbjct: 294 KKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTI-AENGFTGSVPNIPTEMLPQHRAL 352
Query: 335 AREGSAAPLPLYTSPSLPNITLGLPAT----------GPSAGTAGQQDAERLTLPALQQR 384
+ S LYTSPSLPNI+LGL AT P T QQ+AER L +L+Q
Sbjct: 353 PLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLST--QQEAERQALQSLRQG 410
Query: 385 LSLFPGTHLTPYLSTSP---------LERDGGA-AHSPLLQHMVLLEQPPAQAPLVTGLG 434
GT ++STS LE DG H+ LLQH++LLEQ Q+ L+
Sbjct: 411 -----GTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLI---- 461
Query: 435 ALPLHAQS-LVGADRVSPSIH---KLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFL 490
A+PLH QS LV +RV+ S+ KL +HRPL RTQS+PLPQ+ QALQ LV+QQQHQQFL
Sbjct: 462 AVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFL 521
Query: 491 EKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEA 550
EK KQQ QLQ+ KI+ K E RQP +HPEETEEEL E Q +L +P +
Sbjct: 522 EKQKQQ----QLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGST 577
Query: 551 HAQAGVQVKQEPIESDEEEAEPP------REVEPGQRQ-PSEQELLFRQQALLLEQQRIH 603
+++ + +E E D+ E E E E G + P +E + L + Q +
Sbjct: 578 ESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQ 637
Query: 604 QLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLML 663
L+ YQA + A +P H+ L R QSSPA+ S + P K FTTG+VYDT ML
Sbjct: 638 PLQVYQAPLSLATVP-----HQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFML 692
Query: 664 KHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLY 723
KHQC CG++ HPEHAGRIQSIWSRLQETGL KCE IRGRKATL+E+QTVHSE HTLLY
Sbjct: 693 KHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLY 752
Query: 724 GTNPLNRQKLDSKKLLGSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELV 782
GT+PLNRQKLDSKKLLG ++ ++ LPCGG+GVDSDT+WNE+HS+ A R+AVGC++EL
Sbjct: 753 GTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA 812
Query: 783 FKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVH 842
FKVA GELKNGFA++RPPGHHAEEST MGFC+FNSVA+ AKLLQQ+L+V K+LIVDWD+H
Sbjct: 813 FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIH 872
Query: 843 HGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPM 902
HGNGTQQAFY+DPSVLY+SLHRYD+GNFFPGSGAP+EVG GPGVG+NVN+A+TGG+DPP+
Sbjct: 873 HGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPI 932
Query: 903 GDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMG 962
GD EYL AFRTVVMPIA EF+PDVVLVS+GFDAVEGH +PLGGY+++ARCFG+LT+QLM
Sbjct: 933 GDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT 992
Query: 963 LAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVME 1022
LAGGR+VLALEGGHDLTAICDASEACVSALL EL PL E VLQQ+PN NAV ++EKV+E
Sbjct: 993 LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIE 1052
Query: 1023 IHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAE--------KRPD 1074
I SK+W C+Q+ + GRSL EAQ E EEAETV+AMA LSVG + A+ RP
Sbjct: 1053 IQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPA 1112
Query: 1075 EEPMEEEPPL 1084
EEPME+EP L
Sbjct: 1113 EEPMEQEPAL 1122
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 1204 bits (3115), Expect = 0.0
Identities = 667/1149 (58%), Positives = 818/1149 (71%), Gaps = 94/1149 (8%)
Query: 2 SSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAV---------PMDLR 52
S DG+SGR+ +E+L ++ +P TV+V LP + PS++ P++LR
Sbjct: 3 SPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLP-RAMPSSMGGGGGGSPSPVELR 61
Query: 53 LDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHI 112
S+ +P LREQQLQQELLALKQ+QQ+Q+Q+L AEFQ+QH+ L+RQHE QL +H+
Sbjct: 62 GALVGSV---DPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHL 118
Query: 113 KQQQEMLAMKHQQELL--------EHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKES 164
KQQQEMLA K QQE+L E QR+ E+ RQE ELEKQ EQ+L L+NKEK KES
Sbjct: 119 KQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQE-ELEKQRLEQQLLILRNKEKSKES 177
Query: 165 AVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSG---V 221
A+ASTEVK++LQEF+L+K K LNH + P+ W H+SLDQSSPPQSG
Sbjct: 178 AIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGT 235
Query: 222 STSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALK 281
SY P+ G YD++DDFPLRKTASEPNLK+RSRLKQKVAERRSSPLLRRKDG V++ K
Sbjct: 236 PPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFK 295
Query: 282 KRPLDVT------DSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVA 335
KR +++T S C+SAPGSGPSSPN+S ++ AENG +VP+IP E HR +
Sbjct: 296 KRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTI-AENGFTGSVPNIPTEMLPQHRALP 354
Query: 336 REGSAAPLPLYTSPSLPNITLGLPAT----------GPSAGTAGQQDAERLTLPALQQRL 385
+ S LYTSPSLPNI+LGL AT P T QQ+AER L +L+Q
Sbjct: 355 LDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLST--QQEAERQALQSLRQG- 411
Query: 386 SLFPGTHLTPYLSTSP---------LERDGGA-AHSPLLQHMVLLEQPPAQAPLVTGLGA 435
GT ++STS LE DG H+ LLQH++LLEQ Q+ L+ A
Sbjct: 412 ----GTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLI----A 463
Query: 436 LPLHAQS-LVGADRVSPSIH---KLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLE 491
+PLH QS LV +RV+ S+ KL +HRPL RTQS+PLPQ+ QALQ LV+QQQHQQFLE
Sbjct: 464 VPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLE 523
Query: 492 KHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAH 551
K KQQ QLQ+ KI+ K E RQP +HPEETEEEL E Q +L +P +
Sbjct: 524 KQKQQ----QLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTE 579
Query: 552 AQAGVQVKQEPIESDEEEAEPP------REVEPGQRQ-PSEQELLFRQQALLLEQQRIHQ 604
+++ + +E E D+ E E E E G + P +E + L + Q +
Sbjct: 580 SESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQP 639
Query: 605 LRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLK 664
L+ YQA + A +P H+ L R QSSPA+ S + P K FTTG+VYDT MLK
Sbjct: 640 LQVYQAPLSLATVP-----HQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLK 694
Query: 665 HQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYG 724
HQC CG++ HPEHAGRIQSIWSRLQETGL KCE IRGRKATL+E+QTVHSE HTLLYG
Sbjct: 695 HQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYG 754
Query: 725 TNPLNRQKLDSKKLLGSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVF 783
T+PLNRQKLDSKKLLG ++ ++ LPCGG+GVDSDT+WNE+HS+ A R+AVGC++EL F
Sbjct: 755 TSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAF 814
Query: 784 KVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHH 843
KVA GELKNGFA++RPPGHHAEEST MGFC+FNSVA+ AKLLQQ+L+V K+LIVDWD+HH
Sbjct: 815 KVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHH 874
Query: 844 GNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMG 903
GNGTQQAFY+DPSVLY+SLHRYD+GNFFPGSGAP+EVG GPGVG+NVN+A+TGG+DPP+G
Sbjct: 875 GNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIG 934
Query: 904 DAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGL 963
D EYL AFRTVVMPIA EF+PDVVLVS+GFDAVEGH +PLGGY+++ARCFG+LT+QLM L
Sbjct: 935 DVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTL 994
Query: 964 AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEI 1023
AGGR+VLALEGGHDLTAICDASEACVSALL EL PL E VLQQ+PN NAV ++EKV+EI
Sbjct: 995 AGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEI 1054
Query: 1024 HSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAE--------KRPDE 1075
SK+W C+Q+ + GRSL EAQ E EEAETV+AMA LSVG + A+ RP E
Sbjct: 1055 QSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAE 1114
Query: 1076 EPMEEEPPL 1084
EPME+EP L
Sbjct: 1115 EPMEQEPAL 1123
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 1143 bits (2956), Expect = 0.0
Identities = 629/1093 (57%), Positives = 781/1093 (71%), Gaps = 57/1093 (5%)
Query: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
Query: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK QQE+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVE 119
Query: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 120 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 179
Query: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 180 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 239
Query: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 240 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 299
Query: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 300 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 359
Query: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 360 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 417
Query: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 418 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 474
Query: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 475 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 528
Query: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 529 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 580
Query: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 581 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 638
Query: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 639 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 698
Query: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 699 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 758
Query: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 759 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 818
Query: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 819 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 878
Query: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955
GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+
Sbjct: 879 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 938
Query: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015
LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV
Sbjct: 939 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 998
Query: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071
S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ +
Sbjct: 999 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1056
Query: 1072 RPDEEPMEEEPPL 1084
R EPMEEEP L
Sbjct: 1057 RTAGEPMEEEPAL 1069
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 1134 bits (2934), Expect = 0.0
Identities = 627/1093 (57%), Positives = 779/1093 (71%), Gaps = 60/1093 (5%)
Query: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
Query: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
Query: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
Query: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
Query: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
Query: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356
Query: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414
Query: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471
Query: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525
Query: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577
Query: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635
Query: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695
Query: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755
Query: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815
Query: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 875
Query: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955
GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+
Sbjct: 876 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 935
Query: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015
LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV
Sbjct: 936 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 995
Query: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071
S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ +
Sbjct: 996 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1053
Query: 1072 RPDEEPMEEEPPL 1084
R EPMEEEP L
Sbjct: 1054 RTAGEPMEEEPAL 1066
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 1096 bits (2834), Expect = 0.0
Identities = 600/1030 (58%), Positives = 743/1030 (72%), Gaps = 54/1030 (5%)
Query: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
Query: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
Query: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
Query: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
Query: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
Query: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356
Query: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414
Query: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471
Query: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525
Query: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577
Query: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635
Query: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695
Query: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755
Query: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815
Query: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 875
Query: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955
GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+
Sbjct: 876 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 935
Query: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015
LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV
Sbjct: 936 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 995
Query: 1016 SMEKVMEIHS 1025
S++K++EI S
Sbjct: 996 SLQKIIEIQS 1005
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 875 bits (2262), Expect = 0.0
Identities = 495/885 (55%), Positives = 617/885 (69%), Gaps = 54/885 (6%)
Query: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
Query: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
Query: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
Query: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
Query: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
Query: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356
Query: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414
Query: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471
Query: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525
Query: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577
Query: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635
Query: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695
Query: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755
Query: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815
Query: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEV 880
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EV
Sbjct: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 860
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 840 bits (2171), Expect = 0.0
Identities = 518/1062 (48%), Positives = 651/1062 (61%), Gaps = 128/1062 (12%)
Query: 44 PSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ 103
P PMDLR+ + P EP + LLAL++ Q
Sbjct: 35 PQPQPMDLRVGQR---PPVEPPP-----EPTLLALQRPQ--------------------- 65
Query: 104 HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE 163
+LH H+ LA QQ +E R L EL+ +EQ+L+QL +K+K K
Sbjct: 66 ---RLHHHL-----FLAGLQQQRSVEPMR-LSMDTPMPELQVGPQEQELRQLLHKDKSKR 116
Query: 164 SAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVST 223
SAVAS+ VK KL E +L K++A R ++ + P Y + L+ +S +S
Sbjct: 117 SAVASSVVKQKLAEVILKKQQAALERTVH---PNSPGIPYRTLE--PLETEGATRSMLS- 170
Query: 224 SYNHPVLGM-YDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKK 282
S+ PV + D + FPLRKT SEPNLKLR + K K ERR +PLLR++ P +L++
Sbjct: 171 SFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPK-KSLERRKNPLLRKESAP--PSLRR 227
Query: 283 RPLDV---TDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGS 339
RP + + + SS P SG SSPN+S E+G P + S E L RL +E S
Sbjct: 228 RPAETLGDSSPSSSSTPASGCSSPNDS------EHGPNPILGS---EALLGQRLRLQETS 278
Query: 340 AAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLST 399
AP L T LP ITLGLPA + D++R T P L R + H TP
Sbjct: 279 VAPFALPTVSLLPAITLGLPA-------PARADSDRRTHPTLGPRGPILGSPH-TPLFLP 330
Query: 400 SPLERDGGAAHSPLLQHMVLLEQPPAQAPLVT--GLGALPLH-AQSLVGADRVSPSIHKL 456
LE + G LQ ++LL+ + APL+T GLG LP H AQSL+ +R+S S
Sbjct: 331 HGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGS---- 386
Query: 457 RQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPAR 516
H PL RT+S PLP +A A Q + L+ H Q +I + ++P+
Sbjct: 387 GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQ-----------VIKRSAKPSE 435
Query: 517 QPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREV 576
+P + E+L + D L ++ H Q EA P
Sbjct: 436 KPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQ--------------PEARGP--- 478
Query: 577 EPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPAS 636
P Q+ P Q LL EQQR+ ++ + +P++ GGHRPLSRAQSSPA
Sbjct: 479 APLQQHP---------QVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPA- 528
Query: 637 ATFPVSVQEPPTKPR-------------FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQ 683
A +S EP ++ R FTTGL+YD++MLKHQC+CG +S HPEHAGRIQ
Sbjct: 529 APASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQ 588
Query: 684 SIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLA 743
SIWSRLQE GLR +CEC+RGRKA+LEELQ+VHSE H LLYGTNPL+R KLD+ KL G LA
Sbjct: 589 SIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLA 648
Query: 744 S-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGH 802
+FV LPCGGVGVD+DTIWNE+HS+ AAR A G V +L FKVA+ ELKNGFAVVRPPGH
Sbjct: 649 QRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGH 708
Query: 803 HAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSL 862
HA+ ST MGFC+FNSVA+A + LQQ+ SKILIVDWDVHHGNGTQQ FY DPSVLY+SL
Sbjct: 709 HADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISL 768
Query: 863 HRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEF 922
HR+DDGNFFPGSGA DEVG G G GFNVN+A+ GGLDPPMGD EYLAAFR VVMPIA EF
Sbjct: 769 HRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREF 828
Query: 923 APDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAIC 982
+PD+VLVS+GFDA EGHP PLGGY++SA+CFGY+T+QLM LAGG +VLALEGGHDLTAIC
Sbjct: 829 SPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAIC 888
Query: 983 DASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSL 1042
DASEACV+ALLGN +DPL E+ +Q+PN NA+RS+E V+ +HSKYW C+QR S +
Sbjct: 889 DASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWV 948
Query: 1043 IEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 1084
+ EE E VTA+ASLSVG+ AE RP E+ +EEE P+
Sbjct: 949 PRVPGADKEEVEAVTALASLSVGIL-AEDRPSEQLVEEEEPM 989
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 806 bits (2081), Expect = 0.0
Identities = 489/1006 (48%), Positives = 616/1006 (61%), Gaps = 133/1006 (13%)
Query: 100 LSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKE 159
L+ Q +LH H+ LA QQ +E R L EL+ +EQ+L+QL +K+
Sbjct: 59 LALQRPQRLHHHL-----FLAGLQQQRSVEPMR-LSMDTPMPELQVGPQEQELRQLLHKD 112
Query: 160 KGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQS 219
K K SAVAS+ VK KL E +L K++A R ++ + P Y + L+ +S
Sbjct: 113 KSKRSAVASSVVKQKLAEVILKKQQAALERTVH---PNSPGIPYRTLE--PLETEGATRS 167
Query: 220 GVSTSYNHPVLGM-YDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVT 278
+S S+ PV + D + FPLRKT SEPNLKLR + K K ERR +PLLR++ P
Sbjct: 168 MLS-SFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPK-KSLERRKNPLLRKESAP--P 223
Query: 279 ALKKRPLDV---TDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVA 335
+L++RP + + + SS P SG SSPN+S E+G
Sbjct: 224 SLRRRPAETLGDSSPSSSSTPASGCSSPNDS------EHG-------------------- 257
Query: 336 REGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTP 395
PN LG + D++R T P L R + H TP
Sbjct: 258 ----------------PNPILG-----------SEADSDRRTHPTLGPRGPILGSPH-TP 289
Query: 396 YLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVT--GLGALPLH-AQSLVGADRVSPS 452
LE + G LQ ++LL+ + APL+T GLG LP H AQSL+ +R+S S
Sbjct: 290 LFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGS 349
Query: 453 IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPS 512
H PL RT+S PLP +A A Q + L+ H Q +I + +
Sbjct: 350 ----GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQ-----------VIKRSA 394
Query: 513 EPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEP 572
+P+ +P + E+L + D L ++ H Q EA
Sbjct: 395 KPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQ--------------PEARG 440
Query: 573 PREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQS 632
P P Q+ P Q LL EQQR+ ++ + +P++ GGHRPLSRAQS
Sbjct: 441 P---APLQQHP---------QVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQS 488
Query: 633 SPASATFPVSVQEPPTKPR-------------FTTGLVYDTLMLKHQCTCGSSSSHPEHA 679
SPA A +S EP ++ R FTTGL+YD++MLKHQC+CG +S HPEHA
Sbjct: 489 SPA-APASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHA 547
Query: 680 GRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLL 739
GRIQSIWSRLQE GLR +CEC+RGRKA+LEELQ+VHSE H LLYGTNPL+R KLD+ KL
Sbjct: 548 GRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLA 607
Query: 740 GSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR 798
G LA +FV LPCGGVGVD+DTIWNE+HS+ AAR A G V +L FKVA+ ELKNGFAVVR
Sbjct: 608 GLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVR 667
Query: 799 PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVL 858
PPGHHA+ ST MGFC+FNSVA+A + LQQ+ SKILIVDWDVHHGNGTQQ FY DPSVL
Sbjct: 668 PPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVL 727
Query: 859 YMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPI 918
Y+SLHR+DDGNFFPGSGA DEVG G G GFNVN+A+ GGLDPPMGD EYLAAFR VVMPI
Sbjct: 728 YISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPI 787
Query: 919 ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDL 978
A EF+PD+VLVS+GFDA EGHP PLGGY++SA+CFGY+T+QLM LAGG +VLALEGGHDL
Sbjct: 788 AREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDL 847
Query: 979 TAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTA 1038
TAICDASEACV+ALLGN +DPL E+ +Q+PN NA+RS+E V+ +HSKYW C+QR S
Sbjct: 848 TAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCP 907
Query: 1039 GRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 1084
+ + EE E VTA+ASLSVG+ AE RP E+ +EEE P+
Sbjct: 908 DSWVPRVPGADKEEVEAVTALASLSVGIL-AEDRPSEQLVEEEEPM 952
>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
Length = 590
Score = 493 bits (1269), Expect = e-139
Identities = 305/599 (50%), Positives = 397/599 (66%), Gaps = 47/599 (7%)
Query: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
Query: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
Query: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
Query: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
Query: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSA-CSSAPGSGPSSPNNSSGSVSAENGIAPAVP 321
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+PGSGPSSPNN EN + P
Sbjct: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
Query: 322 SIPAETSLA-HRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ--QDAERLTL 378
+ AE ++ R++ E S L LYTSPSLPNITLGLPA PS A ++ ++
Sbjct: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAV-PSQLNASNSLKEKQKCET 355
Query: 379 PALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTG 432
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV
Sbjct: 356 QTLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVA- 413
Query: 433 LGALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQ 488
G +PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQ
Sbjct: 414 -GGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQS--TLAQLVIQQQHQQ 470
Query: 489 FLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ- 547
FLEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 471 FLEKQKQ--YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSG 524
Query: 548 -----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQA 594
+ Q G V+VK+EP++SDE+ +E+E G++ Q+++ + A
Sbjct: 525 NSTRSDSSACVDDTLGQVGAVKVKEEPVDSDED--AQIQEMESGEQAAFMQQVIGKDLA 581
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 301 bits (772), Expect = 2e-81
Identities = 182/399 (45%), Positives = 235/399 (58%), Gaps = 39/399 (9%)
Query: 645 EPPTKPRFT-------TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGK 697
EPP P T TGLVYD M+ H C S HPE RI I RL+E GL G+
Sbjct: 465 EPPVLPILTWPVLQSRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELGLAGR 522
Query: 698 CECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGV 756
C + R AT EL T HS + L T + ++L +
Sbjct: 523 CLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS------------------ 564
Query: 757 DSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFN 816
+ D+I+ + A+LA G LV V +GE+ NG AVVRPPGHHAE+ GFC+FN
Sbjct: 565 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFN 624
Query: 817 SVAVAAKLLQQRLSVS-KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--G 873
SVAVAA+ Q + +ILIVDWDVHHGNGTQ F DPSVLY+SLHRYD G FFP
Sbjct: 625 SVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGD 684
Query: 874 SGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGF 933
GA ++G G GF VN+A+ G P MGDA+YLAA+ +V+PIA EF P++VLVS+GF
Sbjct: 685 EGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGF 741
Query: 934 DAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALL 993
DA G PLGG +S + +LT LMGLA GRI+L LEGG++LT+I ++ AC +LL
Sbjct: 742 DAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLL 799
Query: 994 GNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQ 1032
G DP P L + P + A+ S+ + +++H +YWR L+
Sbjct: 800 G---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLR 835
Score = 251 bits (641), Expect = 3e-66
Identities = 157/404 (38%), Positives = 219/404 (54%), Gaps = 31/404 (7%)
Query: 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713
TGLV D + + C S PE R+ +I +L + GL +C + R A EEL
Sbjct: 86 TGLVLDEQLNEFHCLW--DDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELML 143
Query: 714 VHS-EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAAR 772
VHS E L+ T +N +L LA + D+++ +S A
Sbjct: 144 VHSLEYIDLMETTQYMNEGELRV------LADTY------------DSVYLHPNSYSCAC 185
Query: 773 LAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVS 832
LA G V+ LV V E++NG A++RPPGHHA+ S G+C FN VAVAA+ QQ+ +
Sbjct: 186 LASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIR 245
Query: 833 KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPD--EVGTGPGVGFNV 890
++LIVDWDVHHG GTQ F DPSVLY S+HRY+ G F+P A + G G G G+ +
Sbjct: 246 RVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTI 305
Query: 891 NMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSA 950
N+ + M DA+Y+AAF V++P+A EF P +VLV++GFDA++G P G +
Sbjct: 306 NVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAATP 360
Query: 951 RCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPN 1010
F LT LMGLAGG+++L+LEGG++L A+ + A + LLG DP P P
Sbjct: 361 AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG---DPCPMLESPGAPC 417
Query: 1011 ANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAE 1054
+A S+ +E +W L R+T T R +E E E E
Sbjct: 418 RSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEE 461
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 238 bits (606), Expect = 3e-62
Identities = 144/387 (37%), Positives = 209/387 (54%), Gaps = 27/387 (6%)
Query: 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713
T LVY M + E R+ + RL++ GL +C + R+A+ EEL
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 714 VHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARL 773
VHS + L + ++ K+ L +L+ F D I+ + ARL
Sbjct: 63 VHSPEYVSL-----VRETQVLGKEELQALSGQF------------DAIYFHPSTFHCARL 105
Query: 774 AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSK 833
A G ++LV V TG ++NG A+VRPPGHH + + GFC FN+VA+AA +Q+ + +
Sbjct: 106 AAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHR 165
Query: 834 ILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVN 891
IL+VDWDVHHG G Q F DPSVLY S HRY+ G F+P D VG G G+GF VN
Sbjct: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVN 225
Query: 892 MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951
+ + MG+A+Y+AAF +++P+A EF P++VLVS+GFD+ G P G +
Sbjct: 226 LPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATPE 280
Query: 952 CFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA 1011
CF +LT+ L LAGGR+ LEGG+ L ++ ++ V LLG DP P P
Sbjct: 281 CFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG---DPAPPLSGPMAPCQ 337
Query: 1012 NAVRSMEKVMEIHSKYWRCLQRTTSTA 1038
+A+ S++ + +W+ LQ+ TA
Sbjct: 338 SALESIQSARAAQAPHWKSLQQQDVTA 364
Score = 37.7 bits (86), Expect = 0.059
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960
P+ +L+ +V+P+A F PD+VLV+ G G+ L L L
Sbjct: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597
Query: 961 MGLAGGRIVLALE 973
GLAGGR++ LE
Sbjct: 598 RGLAGGRVLALLE 610
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 207 bits (528), Expect = 3e-53
Identities = 133/387 (34%), Positives = 194/387 (50%), Gaps = 47/387 (12%)
Query: 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713
T LVY M + E R+ + RL++ GL +C + R+A+ EEL
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 714 VHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARL 773
VHS + L + ++ K+ L +L+ F D I+ + ARL
Sbjct: 63 VHSPEYVSL-----VRETQVLGKEELQALSGQF------------DAIYFHPSTFHCARL 105
Query: 774 AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSK 833
A G ++LV V TG ++NG A+VRPPGHH + + GFC FN+VA+AA +Q+ + +
Sbjct: 106 AAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHR 165
Query: 834 ILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVN 891
IL+VDWDVHHG G Q F DPSVLY S HRY+ G F+P D VG G G+GF VN
Sbjct: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVN 225
Query: 892 MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951
+ + MG+A+Y+AAF +++P+A E G +
Sbjct: 226 LPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATPE 260
Query: 952 CFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA 1011
CF +LT+ L LAGGR+ LEGG+ L ++ ++ V LLG DP P P
Sbjct: 261 CFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG---DPAPPLSGPMAPCQ 317
Query: 1012 NAVRSMEKVMEIHSKYWRCLQRTTSTA 1038
+A+ S++ + +W+ LQ+ TA
Sbjct: 318 SALESIQSARAAQAPHWKSLQQQDVTA 344
Score = 37.7 bits (86), Expect = 0.059
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960
P+ +L+ +V+P+A F PD+VLV+ G G+ L L L
Sbjct: 529 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 577
Query: 961 MGLAGGRIVLALE 973
GLAGGR++ LE
Sbjct: 578 RGLAGGRVLALLE 590
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 107 bits (268), Expect = 5e-23
Identities = 89/327 (27%), Positives = 152/327 (46%), Gaps = 63/327 (19%)
Query: 669 CGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPL 728
C S + P+ A + S+ ++ L + ++ + A++EE+ T H++A+
Sbjct: 28 CDSLAKIPKRASMVHSL---IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQ------- 77
Query: 729 NRQKLDSKKLLGSLASVFVRLPCGGVGVD---SDTIWNEVHSAGAARL-AVGCVVELVFK 784
+ QK+ + S+ G+G D ++ I++ + G A + A C+++ + K
Sbjct: 78 HLQKVSQEGDDDHPDSIEY-----GLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK 132
Query: 785 VATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHG 844
VA G+ HHA++ GFCY N + +L+ R +IL VD D+HHG
Sbjct: 133 VAIN-WSGGW-------HHAKKDEASGFCYLNDAVLG--ILRLRRKFERILYVDLDLHHG 182
Query: 845 NGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGD 904
+G + AF V+ +SLH++ G FFPG+G +VG G G ++VN+ G+ D
Sbjct: 183 DGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----D 237
Query: 905 AEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHP------TPL--------------- 943
+Y +V+ + F P V++ G D + G P TP+
Sbjct: 238 EKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLA 297
Query: 944 ------GGYNL--SARCFGYLTKQLMG 962
GGYNL +ARC+ YLT ++G
Sbjct: 298 TLILGGGGYNLANTARCWTYLTGVILG 324
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 104 bits (259), Expect = 5e-22
Identities = 88/305 (28%), Positives = 141/305 (46%), Gaps = 44/305 (14%)
Query: 675 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKL 733
HP RI+ + L GL K E R KA EE+ HS+ + L P N +
Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87
Query: 734 DSKKL----LGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE 789
SK++ +G VF D + ++ + G+ AV +
Sbjct: 88 -SKQMQRFNVGEDCPVF----------DGLFEFCQLSTGGSVASAV----------KLNK 126
Query: 790 LKNGFAVVRPPG-HHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQ 848
+ AV G HHA++S GFCY N + +A +L+ ++L +D D+HHG+G +
Sbjct: 127 QQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIHHGDGVE 184
Query: 849 QAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYL 908
+AFY+ V+ +S H+Y G +FPG+G ++G G G + VN G+D D Y
Sbjct: 185 EAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID----DESYE 238
Query: 909 AAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLS----ARCFGYLTK---QLM 961
A F+ V+ + F P V++ G D++ G LG +NL+ A+C ++ ++
Sbjct: 239 AIFKPVMSKVMEMFQPSAVVLQCGSDSLSG--DRLGCFNLTIKGHAKCVEFVKSFNLPML 296
Query: 962 GLAGG 966
L GG
Sbjct: 297 MLGGG 301
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 103 bits (257), Expect = 9e-22
Identities = 84/289 (29%), Positives = 131/289 (45%), Gaps = 49/289 (16%)
Query: 675 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKL 733
HP RI+ + L GL K E R KAT EE+ HS+ + L P N +
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
Query: 734 DSKKL----LGSLASVF------VRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVF 783
SK++ +G VF +L GG AGA +L
Sbjct: 183 -SKQMQRFNVGEDCPVFDGLFEFCQLSTGG------------SVAGAVKL---------- 219
Query: 784 KVATGELKNGFAVVRPPG-HHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVH 842
+ AV G HHA++S GFCY N + +A +L+ ++L +D D+H
Sbjct: 220 ----NRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIH 273
Query: 843 HGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPM 902
HG+G ++AFY+ V+ +S H+Y G +FPG+G ++G G G + VN G+D
Sbjct: 274 HGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID--- 328
Query: 903 GDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951
D Y F+ ++ + + P V++ G D++ G LG +NL+ +
Sbjct: 329 -DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSG--DRLGCFNLTVK 374
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 86.7 bits (213), Expect = 1e-16
Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 11/154 (7%)
Query: 802 HHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMS 861
HHA++ GFCY N + + +L+ ++L +D D+HHG+G Q+AFY V+ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIG--ILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191
Query: 862 LHRYDDGN-FFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIAS 920
H+Y GN FFPG+G EVG G + +N+ G+D D Y F+ V+ +
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245
Query: 921 EFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFG 954
+ P +++ G D++ LG +NLS R G
Sbjct: 246 FYQPTCIVLQCGADSL--GCDRLGCFNLSIRGHG 277
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/312 (24%), Positives = 124/312 (39%), Gaps = 65/312 (20%)
Query: 670 GSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLN 729
G HP AG+ + + L+E L + R+A+ E+L VH+ + LN
Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 53
Query: 730 RQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE 789
K +K+L L R GG + A +LAV
Sbjct: 54 ELK---RKVLRPL-----RTQTGGTIM-------------AGKLAV-------------- 78
Query: 790 LKNGFAVVRPPG-HHAEESTPMGFCYFNSVAVAAKLLQQRLS-VSKILIVDWDVHHGNGT 847
+ G+A+ G HH GFC + + +A K L +R+ +S+ I+D D H GNG
Sbjct: 79 -ERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 137
Query: 848 QQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEY 907
++ F D V M ++ + + +PG + + G + D EY
Sbjct: 138 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-------AIRRKVELEWGTE----DDEY 183
Query: 908 LAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR 967
L + E PDVV+ ++G D +EG LGG ++S + + + GR
Sbjct: 184 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 241
Query: 968 ---IVLALEGGH 976
I++ GG+
Sbjct: 242 RVPILMVTSGGY 253
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 60.8 bits (146), Expect = 7e-09
Identities = 73/311 (23%), Positives = 120/311 (38%), Gaps = 40/311 (12%)
Query: 670 GSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLN 729
G HP AG+ + + L+E L + R+A+ E+L VH+ + LN
Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 81
Query: 730 RQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE 789
K + + LP V + G +A VE + + G
Sbjct: 82 ELKWSFAVATITEIPPVIFLP--NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG- 138
Query: 790 LKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLS-VSKILIVDWDVHHGNGTQ 848
GF HH GFC + + +A K L +R+ +S+ I+D D H GNG +
Sbjct: 139 --GGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHE 189
Query: 849 QAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYL 908
+ F D V M ++ + + +PG + + G + D EYL
Sbjct: 190 RDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-------AIRRKVELEWGTE----DDEYL 235
Query: 909 AAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR- 967
+ E PDVV+ ++G D +EG LGG ++S + + + GR
Sbjct: 236 DKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGRR 293
Query: 968 --IVLALEGGH 976
I++ GG+
Sbjct: 294 VPILMVTSGGY 304
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 59.3 bits (142), Expect = 2e-08
Identities = 73/268 (27%), Positives = 125/268 (46%), Gaps = 38/268 (14%)
Query: 68 EQQLQQELLALKQKQQ-----IQRQILIAEFQ-RQHEQLSRQHEAQLHEHIKQQQEMLAM 121
E L+++ L L+Q+ + ++RQ L+ E Q R+ E+ RQ A+ + I+QQ+E
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE---- 404
Query: 122 KHQQELLEHQRKLERH-RQEQELEKQHREQ----KLQQLKNKEKGKESAVASTEVKMKL- 175
Q+ LE Q++ ER R++QE E++ REQ +L++L+ + K +E + E K ++
Sbjct: 405 --QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 176 --QEFVLNK-------KKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVS-TSY 225
QE++ + + L + L + QHS Q PPQ S S+
Sbjct: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHS--QQPPPPQQERSKPSF 520
Query: 226 NHPVLGMY----DAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALK 281
+ P + D + P+R T+ P L R Q ++ S R ++++
Sbjct: 521 HAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNS----TSSIE 576
Query: 282 KRPLDVTDSACSSAPGSGPSSPNNSSGS 309
R L PGSG SS +++SGS
Sbjct: 577 PRLLWERVEKLVPRPGSGSSSGSSNSGS 604
Score = 38.1 bits (87), Expect = 0.045
Identities = 38/175 (21%), Positives = 76/175 (43%), Gaps = 16/175 (9%)
Query: 475 QALQHLVIQQQHQ---QFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELRE 531
Q LQ +++Q + Q L + +++ +QQ+ Q ++ + R+ E+ ++ E+ R
Sbjct: 374 QLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL---EEQQRREREARRQQEREQRRR 430
Query: 532 HQALLDEPYLDRLPGQ-KEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLF 590
Q ++ L+ L + KE + + ++ +E ++E E E + +Q+LL
Sbjct: 431 EQE--EKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ 488
Query: 591 RQQALLLEQQRIHQLRNYQ-------ASMEAAGIPVSFGGHRPLSRAQSSPASAT 638
Q LL + +R H + Q S + P + P RA+ P T
Sbjct: 489 EQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTT 543
Score = 33.5 bits (75), Expect = 1.1
Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 17/172 (9%)
Query: 487 QQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPG 546
QQ ++ + ++QQL + + + E RQ + ++ E+ +E + L+E
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 547 QKEAHAQAGVQVKQEPIESDE------EEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 600
+++ + + ++E +E EE E R E +R EQE + RQ L E+Q
Sbjct: 420 RRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQ---LEEEQ 476
Query: 601 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRF 652
R ++ Q E A + HR + P + P Q+ +KP F
Sbjct: 477 RHLEVLQQQLLQEQA---MLLHDHR-----RPHPQHSQQPPPPQQERSKPSF 520
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 58.2 bits (139), Expect = 4e-08
Identities = 52/205 (25%), Positives = 94/205 (45%), Gaps = 43/205 (20%)
Query: 15 QPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQL--- 71
QP ++ R+ + A QV + ++ Q L + L++QQL
Sbjct: 160 QPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQ 219
Query: 72 ------------------QQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIK 113
QQ+LL L+Q+ Q+Q+Q+L + + +QL Q +AQL + +
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLL 279
Query: 114 -QQQEMLAMKHQQELLEHQRKLERHRQ----------EQELE----------KQHREQKL 152
QQQE L + QQ+LL+ Q++ + +Q E+E+E +Q EQ+
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQR 339
Query: 153 QQLKNKEKGKESAVASTEVKMKLQE 177
Q+L+ +++ E ++++KLQE
Sbjct: 340 QELERQQE-LERQQEQRQLQLKLQE 363
Score = 55.8 bits (133), Expect = 2e-07
Identities = 42/137 (30%), Positives = 73/137 (53%), Gaps = 10/137 (7%)
Query: 41 QVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQL 100
Q+ P V RL Q + A +Q LQQ+ + +QQ+Q Q L+ Q+Q EQL
Sbjct: 158 QLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQ---EQLQQQVQEQQLL---QQQQEQL 211
Query: 101 SRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEK 160
+Q Q E ++QQQ + QQE L+ Q++L +Q+ +L++Q +Q+ QL+ +
Sbjct: 212 QQQQLLQQQEQLQQQQ----FQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLL 267
Query: 161 GKESAVASTEVKMKLQE 177
++ A ++ ++ QE
Sbjct: 268 EQQQAQLQQQLLLQQQE 284
Score = 52.8 bits (125), Expect = 2e-06
Identities = 36/139 (25%), Positives = 75/139 (53%), Gaps = 12/139 (8%)
Query: 65 ALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEML----- 119
++ Q+L+ EL + Q+QQ+Q Q + + + Q +Q Q + + + QQQE L
Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199
Query: 120 ---AMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQ----LKNKEKGKESAVASTEVK 172
++ QQE L+ Q+ L++ Q Q+ + Q ++++LQQ L +++G+ + +
Sbjct: 200 EQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQ 259
Query: 173 MKLQEFVLNKKKALAHRNL 191
+LQ+ +L +++A + L
Sbjct: 260 AQLQQQLLEQQQAQLQQQL 278
Score = 50.8 bits (120), Expect = 7e-06
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 27/199 (13%)
Query: 9 GLSGRDQPVELLNPARVNHMPSTVDV-----ATALPLQVAPSAVPMDLRLDHQFSLPVAE 63
G SG + E P N P V A+ + + P + L+ Q P +
Sbjct: 44 GGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQ 103
Query: 64 PALREQQLQQELLALKQK-----------------QQIQRQILIAEFQRQHEQLSRQ-HE 105
P + Q Q L L+Q+ Q + Q L E Q H+Q Q +
Sbjct: 104 PQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQ 163
Query: 106 AQLHEHIKQQQEMLAMK--HQQELLEHQRKLERHRQEQELEKQHREQKLQQ--LKNKEKG 161
Q + ++QQQE L + +Q++L+ Q +L++ QEQ+L +Q +EQ QQ L+ +E+
Sbjct: 164 VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQL 223
Query: 162 KESAVASTEVKMKLQEFVL 180
++ + +++ Q+ +L
Sbjct: 224 QQQQFQQQQEQLQQQQQLL 242
Score = 50.4 bits (119), Expect = 9e-06
Identities = 49/196 (25%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 438 LHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQF 497
+H Q + +V +L+Q + +TQ A Q Q + L Q Q QQ L++ ++Q
Sbjct: 153 MHQQQQLQPQQVQEQ-QRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQL 211
Query: 498 QQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQ 557
QQQQL + E +Q + ++ +E+L++ Q LL +L Q++ Q Q
Sbjct: 212 QQQQLLQQQ------EQLQQQQF--QQQQEQLQQQQQLLLLQQQGQL--QQQLLQQQQAQ 261
Query: 558 VKQEPIESDEEEAEPPREV-EPGQRQPSEQELLFRQQALLLEQQRIHQ---LRNYQASME 613
++Q+ +E + + + + + Q Q +Q+ L +QQ L+QQ++ + +E
Sbjct: 262 LQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVE 321
Query: 614 AAGIPVSFGGHRPLSR 629
+PV G + L +
Sbjct: 322 LELMPVDLGSEQELEQ 337
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/117 (27%), Positives = 70/117 (59%), Gaps = 12/117 (10%)
Query: 66 LREQQLQQELLALKQKQQIQRQILIA------EFQRQHEQLSRQHEAQLHEHIKQQQEML 119
L++QQLQ L +++++++ +++ E ++Q ++L RQ E + +Q+Q L
Sbjct: 302 LQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELER----QQEQRQL 357
Query: 120 AMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQ 176
+K Q+EL + +++LE+ Q+Q+LE+Q + +L ++ + +E + T V+ +LQ
Sbjct: 358 QLKLQEELQQLEQQLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQ 412
Score = 47.4 bits (111), Expect = 7e-05
Identities = 36/158 (22%), Positives = 71/158 (44%), Gaps = 8/158 (5%)
Query: 451 PSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQ----HQQFLEKHKQQFQQQQLQMNK 506
P +L+Q +P Q P Q L L ++ HQ+ + + QQQQLQ +
Sbjct: 104 PQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQ 163
Query: 507 IIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESD 566
+ E R + + ++ +E Q L + L + +++ Q Q++Q+ +
Sbjct: 164 V----QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQ 219
Query: 567 EEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQ 604
+E+ + + + ++ +Q+LL QQ L+QQ + Q
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQ 257
Score = 46.2 bits (108), Expect = 2e-04
Identities = 46/193 (23%), Positives = 88/193 (45%), Gaps = 17/193 (8%)
Query: 456 LRQHRPLGRTQSAPLPQNAQALQHLVIQQQH----QQFLEKHKQQFQQQQLQMNKIIPKP 511
L+Q L + Q + Q Q L++ QQ QQ L++ + Q QQQ L+ + +
Sbjct: 217 LQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ 276
Query: 512 SEPARQPESHPEETEEE-LREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEA 570
+Q E ++ +++ L++ Q L + L P + E + +++ + S++E
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELE 336
Query: 571 EPPREVEPGQ---RQPSEQELLFRQQALL------LEQQRIHQLRNYQASMEAAGIPVSF 621
+ +E+E Q RQ +++L + Q L LEQQ+ QL + +E PV
Sbjct: 337 QQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQ-QQLEQQEVQLELT--PVEL 393
Query: 622 GGHRPLSRAQSSP 634
G + + + +P
Sbjct: 394 GAQQQEVQLELTP 406
Score = 41.2 bits (95), Expect = 0.005
Identities = 60/257 (23%), Positives = 109/257 (42%), Gaps = 43/257 (16%)
Query: 361 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLS-TSPLERDGGAAHSPLLQHMVL 419
+G S G+ Q++ E + QR ++ + T P +R+ LQ L
Sbjct: 43 SGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRE--------LQLQQL 94
Query: 420 LEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNA-QALQ 478
+QP Q P H Q + P + +Q + G+ Q + L Q Q++
Sbjct: 95 EQQPEPQQQ--------PQHEQ----LQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVH 142
Query: 479 H--------LVIQQQHQQFLEKHKQQ-FQQQQLQMNKIIPKPSEPARQPESHPEETEEE- 528
H L+ QQQ Q + +QQ QQQQ Q+ + + +Q E ++ +E+
Sbjct: 143 HQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQ 202
Query: 529 -LREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQE 587
L++ Q L Q++ Q Q++Q+ + +E+ + +++ Q+Q Q+
Sbjct: 203 LLQQQQEQL----------QQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQ 252
Query: 588 LLFRQQALLLEQQRIHQ 604
L +QQ L+QQ + Q
Sbjct: 253 QLLQQQQAQLQQQLLEQ 269
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/340 (22%), Positives = 145/340 (42%), Gaps = 38/340 (11%)
Query: 42 VAPSAVPMDLRLDHQFSLPVAEPALREQQLQQEL-----LALKQKQQIQRQILIAEFQRQ 96
+AP ++ + Q L + + AL++QQ QQ+ AL+Q+QQ Q+Q +FQ Q
Sbjct: 136 MAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ---QQFQAQ 192
Query: 97 HEQLSRQHEA------QLHEHIKQQQEMLAMKH--QQELLEHQRKLERHRQEQELEKQHR 148
+ +Q +A QL + +QQQ ++ + H QQ++ + Q++L+R Q Q ++Q +
Sbjct: 193 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ 252
Query: 149 EQKLQQLKNKEKGKESAVASTEVKMKL--QEFVLNKKKALAHRNLNHCISSDPRY-WYGK 205
+Q+ QQ + + + + ++ L ++ H +H P+ +
Sbjct: 253 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ 312
Query: 206 TQHSSLDQSSPPQSGVSTSYNHPVLGMYD------AKDDFPLRKTASEPNLKLR------ 253
Q S L S Q VS + P +Y + +++ +P ++ +
Sbjct: 313 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT 372
Query: 254 SRLKQKVA-----ERRSSPLLRR-KDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSS 307
++ Q VA + S P+L G V + P S P S P+S N SS
Sbjct: 373 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNS-NVSS 431
Query: 308 GSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYT 347
G + + P+ P+++ + R +P PL T
Sbjct: 432 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNT 471
Score = 51.6 bits (122), Expect = 4e-06
Identities = 76/334 (22%), Positives = 131/334 (39%), Gaps = 62/334 (18%)
Query: 356 LGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQ 415
+G+P GP G +L A+ Q +SL P G A HS
Sbjct: 99 IGMPPRGPGQSLGGMG-----SLGAMGQPMSLS---------GQPPPGTSGMAPHS---- 140
Query: 416 HMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGR--TQSAPLPQN 473
M ++ Q L AL Q + ++ + +Q + + Q + + Q
Sbjct: 141 -MAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQ 199
Query: 474 AQAL----QHLVIQQQHQQFLEK----HKQQFQQQQLQMNKIIPKPSEPARQPESHPEET 525
QA+ Q L QQQ QQ L K ++QQ QQQQ Q+ +I + +Q + ++
Sbjct: 200 FQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQ 259
Query: 526 EEELREHQALLDEPYLDR--------LPGQKE-----AHAQAGVQVKQEPIESDEEEAEP 572
+++ + Q + +P + + LP Q + H Q Q +Q P+ ++ P
Sbjct: 260 QQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLP 319
Query: 573 PR----------EVEPGQRQPSEQELLFRQQALLLEQQRIH-QLRNYQ--------ASME 613
P+ + PGQ ++ L F + ++++Q + Q++ Q A M
Sbjct: 320 PQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMV 379
Query: 614 AAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPP 647
A G+ VS P+ + S P S+ PP
Sbjct: 380 APGVQVS-QSSLPMLSSPSPGQQVQTPQSMPPPP 412
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 56.2 bits (134), Expect = 2e-07
Identities = 95/419 (22%), Positives = 173/419 (41%), Gaps = 60/419 (14%)
Query: 42 VAPSAVPMDLRLDHQFSLPVAEPALREQQLQQEL-----LALKQKQQIQRQILIAEFQRQ 96
+AP ++ + Q L + + AL++QQ QQ+ AL+Q+QQ Q+Q +FQ Q
Sbjct: 136 MAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ---QQFQAQ 192
Query: 97 HEQLSRQHEA-----QLHEHIKQQQEMLAMKH---QQELLEHQRKLERHRQEQELEKQHR 148
+ +Q +A Q + +QQQ+ L H QQ++ + Q++L+R Q Q ++Q +
Sbjct: 193 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ 252
Query: 149 EQKLQQLKNKEKGKESAVASTEVKMKL--QEFVLNKKKALAHRNLNHCISSDPRYWYGKT 206
+Q+ QQ + + + + ++ L ++ H +H P
Sbjct: 253 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQP------- 305
Query: 207 QHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSS 266
Q + Q+ P Q S P++ A P + ++P LK R V +
Sbjct: 306 QQPPVAQNQPSQL-PPQSQTQPLVSQAQA---LPGQMLYTQPPLKF-VRAPMVVQQPPVQ 360
Query: 267 PLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAP--AVPSIP 324
P ++++ V TA +A APG + + G + P AV +IP
Sbjct: 361 PQVQQQQTAVQTA---------QAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIP 411
Query: 325 AETSLAHRLVAREGSAAPLPLYTSPS---------------LPNITLGLPATGPSAG-TA 368
+ + R + S + LP+ +SPS P+ G P++ P++ ++
Sbjct: 412 SSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS 471
Query: 369 GQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQA 427
G + LP+ + S P T TP + P G ++P+ V+ +QA
Sbjct: 472 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVP---SPGPLNTPVNPSSVMSPAGSSQA 527
Score = 53.9 bits (128), Expect = 8e-07
Identities = 54/253 (21%), Positives = 108/253 (42%), Gaps = 35/253 (13%)
Query: 432 GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQ--- 488
G+G+L Q + + + P + H S PQ LQ + +QQQ QQ
Sbjct: 112 GMGSLGAMGQPMSLSGQPPPGTSGMAPHSMA--VVSTATPQTQLQLQQVALQQQQQQQQF 169
Query: 489 ------FLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALL---DEP 539
L++ +QQ QQQQ Q + + A + + +++ ++H L ++
Sbjct: 170 QQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQ 229
Query: 540 YLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPG-QRQPSEQELLFRQQALLLE 598
+ + Q + AQ +Q +Q+ + +++ + + +P Q+ P +Q QAL +
Sbjct: 230 QIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQ 289
Query: 599 QQRIHQLRNYQ----------ASMEAAGIPVSFGGHRPLSRAQSSPASATF--------- 639
Q++H +++Q A + + +P +S+AQ+ P +
Sbjct: 290 LQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVR 349
Query: 640 -PVSVQEPPTKPR 651
P+ VQ+PP +P+
Sbjct: 350 APMVVQQPPVQPQ 362
Score = 48.9 bits (115), Expect = 3e-05
Identities = 65/294 (22%), Positives = 119/294 (40%), Gaps = 53/294 (18%)
Query: 356 LGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQ 415
+G+P GP G +L A+ Q +SL P G A HS
Sbjct: 99 IGMPPRGPGQSLGGMG-----SLGAMGQPMSLS---------GQPPPGTSGMAPHS---- 140
Query: 416 HMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGR--TQSAPLPQN 473
M ++ Q L AL Q + ++ + +Q + + Q + + Q
Sbjct: 141 -MAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQ 199
Query: 474 AQAL----QHLVIQQQHQQFLEK----HKQQFQQQQLQMNKIIPKPSEPARQPESHPEET 525
QA+ Q L QQQ QQ L K ++QQ QQQQ Q+ +I + +Q + ++
Sbjct: 200 FQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQ 259
Query: 526 EEELREHQALLDEPYLDR--------LPGQKE-----AHAQAGVQVKQEPIESDEEEAEP 572
+++ + Q + +P + + LP Q + H Q Q +Q P+ ++ P
Sbjct: 260 QQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLP 319
Query: 573 PR----------EVEPGQRQPSEQELLFRQQALLLEQQRIH-QLRNYQASMEAA 615
P+ + PGQ ++ L F + ++++Q + Q++ Q +++ A
Sbjct: 320 PQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTA 373
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/190 (27%), Positives = 91/190 (47%), Gaps = 17/190 (8%)
Query: 39 PLQVAPSAVPMDLRL--DHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQ 96
PLQV S M ++ Q + + L QQL Q LL +Q +Q+Q L +++Q
Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQL-QALLQQQQAVMLQQQQLQEFYKKQ 142
Query: 97 HEQLS----RQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKL 152
EQL +Q + Q + +QQQ+ + QQ+ + Q++ ++ +Q+Q KQ +EQ+
Sbjct: 143 QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQ 202
Query: 153 QQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLD 212
QQ + ++ + V ++ LQ L +++ L IS P ++L
Sbjct: 203 QQQQQQQLAAQQLVFQQQL---LQMQQLQQQQHLLSLQRQGLISIPP-------GQAALP 252
Query: 213 QSSPPQSGVS 222
S PQ+G+S
Sbjct: 253 VQSLPQAGLS 262
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/129 (30%), Positives = 64/129 (49%), Gaps = 12/129 (9%)
Query: 32 VDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQL-----QQELLALKQKQQIQR 86
V VA P + P M L Q P AL +QQ QQ+L +KQQ Q
Sbjct: 89 VSVAMMTPQVITPQQ--MQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQL 146
Query: 87 QILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQ 146
+ + + Q+Q +Q +Q + Q +QQQ+ + QQ+ + Q++ ++H +Q E+Q
Sbjct: 147 HLQLLQQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQ 201
Query: 147 HREQKLQQL 155
++Q+ QQL
Sbjct: 202 QQQQQQQQL 210
Score = 40.8 bits (94), Expect = 0.007
Identities = 66/291 (22%), Positives = 110/291 (37%), Gaps = 63/291 (21%)
Query: 362 GPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLE 421
G S+G + + L LQQ+ +L L TS L+ SP
Sbjct: 34 GRSSGDTSSE-VSTVELLHLQQQQALQAARQLLLQQQTSGLK-------SPKSSDKQRPL 85
Query: 422 QPPAQAPLVTGLGALPLHAQSLVGADRVSPS-IHKLRQHRPLGRTQSAPLP------QNA 474
Q P ++T P Q ++ +SP + L Q + Q L Q
Sbjct: 86 QVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQ 145
Query: 475 QALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQA 534
LQ L QQQ QQ ++ +QQ QQQQ Q + + + +Q + HP
Sbjct: 146 LHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHP------------ 193
Query: 535 LLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQA 594
G Q K++ ++ + Q+Q + Q+L+F+QQ
Sbjct: 194 --------------------GKQAKEQ------------QQQQQQQQQLAAQQLVFQQQ- 220
Query: 595 LLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQE 645
LL+ Q++ Q + + S++ G+ +S + QS P + P +Q+
Sbjct: 221 -LLQMQQLQQ-QQHLLSLQRQGL-ISIPPGQAALPVQSLPQAGLSPAEIQQ 268
>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
Length = 740
Score = 55.8 bits (133), Expect = 2e-07
Identities = 48/191 (25%), Positives = 89/191 (46%), Gaps = 17/191 (8%)
Query: 32 VDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIA 91
V VA P + P + L+ V P + LQQ+ + Q+QQ+Q +
Sbjct: 114 VSVAMMTPQVITPQQMQQILQQQ------VLSPQQLQALLQQQQAVMLQQQQLQ-EFYKK 166
Query: 92 EFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQK 151
+ ++ H QL +Q + Q + +QQQ+ + QQ+ + Q++ ++ +Q+Q KQ +EQ+
Sbjct: 167 QQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQ 226
Query: 152 LQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSL 211
QQ + ++ + V ++ LQ L +++ L IS P ++L
Sbjct: 227 QQQQQQQQLAAQQLVFQQQL---LQMQQLQQQQHLLSLQRQGLISIPP-------GQAAL 276
Query: 212 DQSSPPQSGVS 222
S PQ+G+S
Sbjct: 277 PVQSLPQAGLS 287
Score = 47.4 bits (111), Expect = 7e-05
Identities = 30/109 (27%), Positives = 66/109 (60%), Gaps = 4/109 (3%)
Query: 57 FSLPVAEPALREQQLQ-QELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQ 115
F++PV+ + Q + Q++ + Q+Q + Q L A Q+Q + +Q QL E K+Q
Sbjct: 110 FAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQ--QLQEFYKKQ 167
Query: 116 QEMLAMKH-QQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE 163
QE L ++ QQ+ + Q++ ++ +Q+Q+ ++Q ++Q+ QQ + +++ ++
Sbjct: 168 QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 216
Score = 39.3 bits (90), Expect = 0.020
Identities = 51/229 (22%), Positives = 89/229 (38%), Gaps = 55/229 (24%)
Query: 424 PAQAPLVTGLGALPLHAQSLVGADRVSPS-IHKLRQHRPLGRTQSAPLP------QNAQA 476
P ++T P Q ++ +SP + L Q + Q L Q
Sbjct: 113 PVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLH 172
Query: 477 LQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALL 536
LQ L QQQ QQ ++ +QQ QQQQ Q + + + +Q + HP
Sbjct: 173 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHP-------------- 218
Query: 537 DEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
G Q K++ ++ + Q+Q + Q+L+F+QQ L
Sbjct: 219 ------------------GKQAKEQ------------QQQQQQQQQLAAQQLVFQQQ--L 246
Query: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQE 645
L+ Q++ Q + + S++ G+ +S + QS P + P +Q+
Sbjct: 247 LQMQQLQQ-QQHLLSLQRQGL-ISIPPGQAALPVQSLPQAGLSPAEIQQ 293
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 55.8 bits (133), Expect = 2e-07
Identities = 77/321 (23%), Positives = 136/321 (42%), Gaps = 90/321 (28%)
Query: 68 EQQLQQELLALKQKQQ-----IQRQILIAEFQ-RQHEQLSRQHEAQLHEHIKQQQEMLAM 121
E L+++ L L+Q+ + ++RQ L+ E Q R+ E+ RQ A+ + I+QQ+E
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE---- 404
Query: 122 KHQQELLEHQRKLERH-RQEQELEKQHREQ----KLQQLKNKEKGKESAVASTEVKMK-- 174
Q+ LE Q++ ER R++QE E++ REQ +L++L+ + K +E + E K +
Sbjct: 405 --QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 175 -------------------LQEFVLNKKKALAH-------------------RNLNHCIS 196
LQ+ +L ++ L H R+ +
Sbjct: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHA 522
Query: 197 SDPRYWY-------------GKTQHSSLDQSS--------PPQSGVSTSYNHPVLGMYDA 235
+P+ Y KT HSS + S PP S S+++ ++
Sbjct: 523 PEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNG-----NS 577
Query: 236 KDDFPLRKTASEPNLKLRSRLKQKVAERRSSPL-------LRRKDGPVVTALKKRPLDVT 288
+ P + +EP + +R+ + V RR SPL + ++++ R L
Sbjct: 578 ESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWER 637
Query: 289 DSACSSAPGSGPSSPNNSSGS 309
PGSG SS +++SGS
Sbjct: 638 VEKLVPRPGSGSSSGSSNSGS 658
Score = 36.2 bits (82), Expect = 0.17
Identities = 31/139 (22%), Positives = 66/139 (47%), Gaps = 9/139 (6%)
Query: 475 QALQHLVIQQQHQ---QFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELRE 531
Q LQ +++Q + Q L + +++ +QQ+ Q ++ + R+ E+ ++ E+ R
Sbjct: 374 QLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL---EEQQRREREARRQQEREQRRR 430
Query: 532 HQALLDEPYLDRLPGQ-KEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLF 590
Q ++ L+ L + KE + + ++ +E ++E E E + +Q+LL
Sbjct: 431 EQE--EKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ 488
Query: 591 RQQALLLEQQRIHQLRNYQ 609
Q LL + +R H + Q
Sbjct: 489 EQAMLLHDHRRPHPQHSQQ 507
Score = 33.5 bits (75), Expect = 1.1
Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 17/172 (9%)
Query: 487 QQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPG 546
QQ ++ + ++QQL + + + E RQ + ++ E+ +E + L+E
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 547 QKEAHAQAGVQVKQEPIESDE------EEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 600
+++ + + ++E +E EE E R E +R EQE + RQ L E+Q
Sbjct: 420 RRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQ---LEEEQ 476
Query: 601 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRF 652
R ++ Q E A + HR + P + P Q+ +KP F
Sbjct: 477 RHLEVLQQQLLQEQA---MLLHDHR-----RPHPQHSQQPPPPQQERSKPSF 520
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 54.7 bits (130), Expect = 5e-07
Identities = 92/374 (24%), Positives = 156/374 (41%), Gaps = 42/374 (11%)
Query: 62 AEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHE-HIKQQQEMLA 120
A+P QQLQQ+ L+Q+QQ+Q+Q Q +QL +Q + Q + +QQQ+ L
Sbjct: 3891 AQPMGSLQQLQQQQ-QLQQQQQLQQQ--------QQQQLQQQQQLQQQQLQQQQQQQQLQ 3941
Query: 121 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQ-LKNKEKGKESAVASTEVKMKLQEFV 179
+ QQ+L + Q++L++ +Q+Q+ + Q ++Q+ Q L N+ + S + ++ L +
Sbjct: 3942 QQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGM 4001
Query: 180 LNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQ--SSPPQSGVSTSYNHPVLGMYDAKD 237
K L H + + P + +++D SS G ST P L + +
Sbjct: 4002 --PAKPLQHFSSPGALG--PTLLLTGKEQNTVDPAVSSEATEGPSTHQGGP-LAIGTTPE 4056
Query: 238 DFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPG 297
+P+L S+L + + P + P+ + P
Sbjct: 4057 SMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPL-----RLPGQQQQQVSLLHTA 4111
Query: 298 SGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLG 357
G S SGS S A +VP + A+ S++ L + GS L P P +
Sbjct: 4112 GGGSHGQLGSGSSSE----ASSVPHLLAQPSVS--LGDQPGSMTQNLL--GPQQPMLERP 4163
Query: 358 LPA-TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQH 416
+ TGP G P LQ L PG + P + + G A +P L+H
Sbjct: 4164 MQNNTGPQPPKPG---------PVLQSGQGL-PGVGIMPTVGQLRAQLQGVLAKNPQLRH 4213
Query: 417 MVLLEQPPAQAPLV 430
+ +Q QA L+
Sbjct: 4214 LSPQQQQQLQALLM 4227
Score = 50.1 bits (118), Expect = 1e-05
Identities = 69/283 (24%), Positives = 115/283 (40%), Gaps = 26/283 (9%)
Query: 370 QQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPL 429
QQ L A+QQ+ PG L P ++H LL L QPP
Sbjct: 3742 QQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQ-LSPQPPQGPQG 3800
Query: 430 VTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPL--PQNAQALQ----HLVIQ 483
+ G + + Q GA + HR + TQS L PQ AQ Q H ++
Sbjct: 3801 MLGPAQVAVLQQQHPGA------LGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVT 3854
Query: 484 QQHQQFLEKHKQQFQ-------QQQLQMNKIIPKPSEPARQPESHPEETEEELR-EHQAL 535
Q QQ ++H+QQ QQ L + PK S QP ++ +++ + + Q
Sbjct: 3855 AQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSA---QPMGSLQQLQQQQQLQQQQQ 3911
Query: 536 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 595
L + +L Q++ Q Q +Q+ +++ + ++ + Q+Q +Q+ F+QQ
Sbjct: 3912 LQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQ 3971
Query: 596 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQ--SSPAS 636
+ ++Q R + + V+ G P Q SSP +
Sbjct: 3972 QQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGA 4014
Score = 47.8 bits (112), Expect = 6e-05
Identities = 115/553 (20%), Positives = 201/553 (36%), Gaps = 106/553 (19%)
Query: 67 REQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQE 126
++QQ Q+ ++ +Q+ ++ Q +LS Q L + ++QQQ++ + Q+
Sbjct: 3859 QQQQQHQQQGSMAGLSHLQQSLMSHSGQ---PKLSAQPMGSLQQ-LQQQQQLQQQQQLQQ 3914
Query: 127 LLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKAL 186
+ Q + ++ Q+Q+L++Q ++Q+LQQ + ++ ++ + + + Q+F ++
Sbjct: 3915 QQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQ--- 3971
Query: 187 AHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTAS 246
+ Q L+QS S LG PL+ +S
Sbjct: 3972 ------------------QQQMGLLNQSRTLLSPQQQQQQQVALG--PGMPAKPLQHFSS 4011
Query: 247 E----PNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSS 302
P L L + + V SS +GP S GP +
Sbjct: 4012 PGALGPTLLLTGKEQNTVDPAVSS---EATEGP------------------STHQGGPLA 4050
Query: 303 PNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSL-------PNIT 355
+ S++ E G PS+ ++ L LV + P L P L ++
Sbjct: 4051 IGTTPESMATEPG--EVKPSLSGDSQLL--LVQPQPQPQPSSLQLQPPLRLPGQQQQQVS 4106
Query: 356 LGLPATGPSAGTAGQ-QDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLL 414
L A G S G G +E ++P HL S S ++ G +
Sbjct: 4107 LLHTAGGGSHGQLGSGSSSEASSVP------------HLLAQPSVSLGDQPGS-----MT 4149
Query: 415 QHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNA 474
Q+++ +QP + P+ G P ++ + + P + + L L +N
Sbjct: 4150 QNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNP 4209
Query: 475 QALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQ----------------- 517
Q L+HL QQQ Q L+ Q Q QQ Q + P EP Q
Sbjct: 4210 Q-LRHLSPQQQQQ--LQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266
Query: 518 --PESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPRE 575
P++ P +EL P L PG G P S +E P +
Sbjct: 4267 PGPQTGP---LQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL 4323
Query: 576 VEPGQRQPSEQEL 588
P + P+E +L
Sbjct: 4324 PSPSSQLPTEAQL 4336
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 5/103 (4%)
Query: 45 SAVPMDL--RLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSR 102
SA PM +L Q L + ++QQ Q + Q+QQ+Q+Q + Q+Q +Q +
Sbjct: 3890 SAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQ 3949
Query: 103 QHEAQLHEHIKQQQEMLAMKHQQE---LLEHQRKLERHRQEQE 142
Q + QL + +QQQ+ + QQ+ LL R L +Q+Q+
Sbjct: 3950 QQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQ 3992
Score = 37.0 bits (84), Expect = 0.10
Identities = 71/296 (23%), Positives = 98/296 (33%), Gaps = 54/296 (18%)
Query: 264 RSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSI 323
R SPL PVV+ L P +S S P P+SP + +S +P P
Sbjct: 652 RLSPL------PVVSRLSPPP---EESPLSPPPEESPTSPPPEASRLSPPPEDSPTSP-- 700
Query: 324 PAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQ 383
P E S A E S LPL SP LP LP Q
Sbjct: 701 PPEDSPASP--PPEDSLMSLPLEESPLLP-------------------------LPEEPQ 733
Query: 384 RLSLFPGTHLTPYLSTSPLERDGGAAH-SPLLQHMVLLEQPPAQAPLVTGLGALPLHAQS 442
G HL+P L H SP + L QP + P + + P H
Sbjct: 734 LCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQP--EEPCLCAVPEEP-HLSP 790
Query: 443 LVGADRVSPSIHKLRQHRPLGRTQSAPLPQNA-----QALQHLVIQQQHQQFLEKHKQQF 497
+SP +L +P+P+ HL Q + + ++
Sbjct: 791 QAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESH 850
Query: 498 QQQQLQMNKIIPKPSEPARQPESHPEETEEEL------REHQALLDEPYLDRLPGQ 547
+L+ + P+P +P +P P E L LL EP L PG+
Sbjct: 851 LSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSE-PGE 905
Score = 30.4 bits (67), Expect = 9.5
Identities = 41/153 (26%), Positives = 63/153 (41%), Gaps = 19/153 (12%)
Query: 478 QHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEEL-------- 529
+ L +QQQ Q +K +QQ QQQQ Q ++ + + +Q + +T + L
Sbjct: 3719 RQLQLQQQRMQLAQKLQQQ-QQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLM 3777
Query: 530 --REHQALLDEPYLDRLP-GQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQ-RQPSE 585
HQ LL + + P G + A V V Q+ P R+V Q R S
Sbjct: 3778 PPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSS 3837
Query: 586 QELLFRQQALL------LEQQRIHQLRNYQASM 612
+L + Q L+ +QQ+ Q Q SM
Sbjct: 3838 PQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSM 3870
>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
Length = 623
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/162 (25%), Positives = 80/162 (49%), Gaps = 11/162 (6%)
Query: 61 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 120
V P + LQQ+ + Q+QQ+Q + + ++ H QL +Q + Q + +QQQ+
Sbjct: 20 VLSPQQLQALLQQQQAVMLQQQQLQ-EFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQ 78
Query: 121 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 180
+ QQ+ + Q++ ++ +Q+Q KQ +EQ+ QQ + ++ + V ++ LQ L
Sbjct: 79 QQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQL---LQMQQL 135
Query: 181 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVS 222
+++ L IS P ++L S PQ+G+S
Sbjct: 136 QQQQHLLSLQRQGLISIPP-------GQAALPVQSLPQAGLS 170
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/118 (25%), Positives = 68/118 (57%), Gaps = 7/118 (5%)
Query: 61 VAEPALREQQLQQELLALKQKQQI-QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEML 119
V P +Q LQQ++L+ +Q Q + Q+Q + Q+Q ++ ++ + QLH + QQQ+
Sbjct: 6 VITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQ-- 63
Query: 120 AMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQE 177
QQ+ + Q++ ++ +Q+Q+ ++Q ++Q+ QQ + ++ + A + + + Q+
Sbjct: 64 ----QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQ 117
Score = 49.7 bits (117), Expect = 2e-05
Identities = 40/174 (22%), Positives = 81/174 (46%), Gaps = 8/174 (4%)
Query: 472 QNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELRE 531
Q Q LQ V+ Q Q L + +Q QQ Q+ + K E ++ +++ ++
Sbjct: 11 QMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQ 70
Query: 532 HQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFR 591
Q + + Q++ Q Q +Q P + +E+ + ++ Q+Q + Q+L+F+
Sbjct: 71 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQ----QQQLAAQQLVFQ 126
Query: 592 QQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQE 645
QQ LL+ Q++ Q + + S++ G+ +S + QS P + P +Q+
Sbjct: 127 QQ--LLQMQQLQQ-QQHLLSLQRQGL-ISIPPGQAALPVQSLPQAGLSPAEIQQ 176
Score = 49.3 bits (116), Expect = 2e-05
Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 10/108 (9%)
Query: 53 LDHQFSLPVAEPALREQQL-----QQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQ 107
L Q P AL +QQ QQ+L +KQQ Q + + + Q+Q +Q +Q + Q
Sbjct: 16 LQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQ 75
Query: 108 LHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQL 155
+QQQ+ + QQ+ + Q++ ++H +Q E+Q ++Q+ QQL
Sbjct: 76 -----QQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQL 118
Score = 33.9 bits (76), Expect = 0.86
Identities = 21/82 (25%), Positives = 37/82 (45%)
Query: 470 LPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEEL 529
L Q Q Q QQQ QQ ++ +QQ QQQQ Q + + + + ++ +++L
Sbjct: 59 LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQL 118
Query: 530 REHQALLDEPYLDRLPGQKEAH 551
Q + + L Q++ H
Sbjct: 119 AAQQLVFQQQLLQMQQLQQQQH 140
>gi|226246533 TOX high mobility group box family member 3 isoform 2
[Homo sapiens]
Length = 571
Score = 54.3 bits (129), Expect = 6e-07
Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 13/162 (8%)
Query: 2 SSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQV-APSAVPMDLRLDHQFSLP 60
S Q+ L P L +N + ++V +A +P + AP M +
Sbjct: 366 SPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPST 425
Query: 61 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 120
P+++ QQ Q +L +Q+QQ Q Q Q Q +QL +QH Q+H+ I+QQ +
Sbjct: 426 QVSPSVQTQQHQMQLQQQQQQQQQQMQ------QMQQQQL-QQH--QMHQQIQQQMQQQH 476
Query: 121 MKH--QQELLEHQRKLERHRQEQELEKQHREQ-KLQQLKNKE 159
+H QQ L + Q+ L++ +Q+L++Q +++ +LQQL++ +
Sbjct: 477 FQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQ 518
Score = 50.8 bits (120), Expect = 7e-06
Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 15/121 (12%)
Query: 31 TVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILI 90
T V +A QV+PS HQ L ++QQ QQ+ + Q+QQ+Q+ +
Sbjct: 416 TTMVGSAPSTQVSPSVQTQQ----HQMQLQ------QQQQQQQQQMQQMQQQQLQQHQMH 465
Query: 91 AEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE-KQHRE 149
+ Q+Q +Q QH Q +H++QQQ+ L + Q+ L+ Q L++ Q Q+L+ QH+
Sbjct: 466 QQIQQQMQQQHFQHHMQ--QHLQQQQQHLQQQINQQQLQQQ--LQQRLQLQQLQHMQHQS 521
Query: 150 Q 150
Q
Sbjct: 522 Q 522
Score = 47.4 bits (111), Expect = 7e-05
Identities = 58/239 (24%), Positives = 106/239 (44%), Gaps = 31/239 (12%)
Query: 368 AGQQDAERLTLPALQQRLSLFPGTHLTP-YLSTSPLERDGGAAHSP-LLQHMVLLEQPPA 425
A + AE T+ ++QQ L+ T+LT L +PL + G + SP LQ L + A
Sbjct: 325 AAAESAEAQTIRSVQQTLA---STNLTSSLLLNTPLSQHGTVSASPQTLQQS--LPRSIA 379
Query: 426 QAPLVTGLGALPLHAQSLVGADRVS----PSIHKLRQHRPLGRTQSAPLPQNAQALQHLV 481
PL L + + A+ S P I + +G S + + Q QH +
Sbjct: 380 PKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTM-VGSAPSTQVSPSVQTQQHQM 438
Query: 482 IQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYL 541
QQ QQ ++ QQ QQQQLQ +++ + + +Q + ++ L++ Q +L
Sbjct: 439 QLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQ-QHFQHHMQQHLQQQQ-----QHL 492
Query: 542 DRLPGQKEAHAQAGVQVKQEPIESDEEEAEP-PREVEP------------GQRQPSEQE 587
+ Q++ Q +++ + ++ + +++P PR+ P G QP+ Q+
Sbjct: 493 QQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQ 551
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/79 (26%), Positives = 48/79 (60%), Gaps = 6/79 (7%)
Query: 101 SRQHEAQLHEHIKQQQEMLAMKHQQELLEHQ--RKLERHRQEQELEKQHREQKLQQLKNK 158
++QH+ QL + +QQQ+ + QQ+L +HQ +++++ Q+Q + H +Q LQQ +
Sbjct: 433 TQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQ-HHMQQHLQQ---Q 488
Query: 159 EKGKESAVASTEVKMKLQE 177
++ + + +++ +LQ+
Sbjct: 489 QQHLQQQINQQQLQQQLQQ 507
>gi|226054295 TOX high mobility group box family member 3 isoform 1
[Homo sapiens]
Length = 576
Score = 54.3 bits (129), Expect = 6e-07
Identities = 46/162 (28%), Positives = 83/162 (51%), Gaps = 13/162 (8%)
Query: 2 SSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQV-APSAVPMDLRLDHQFSLP 60
S Q+ L P L +N + ++V +A +P + AP M +
Sbjct: 371 SPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPST 430
Query: 61 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 120
P+++ QQ Q +L +Q+QQ Q Q Q Q +QL +QH Q+H+ I+QQ +
Sbjct: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQ------QMQQQQL-QQH--QMHQQIQQQMQQQH 481
Query: 121 MKH--QQELLEHQRKLERHRQEQELEKQHREQ-KLQQLKNKE 159
+H QQ L + Q+ L++ +Q+L++Q +++ +LQQL++ +
Sbjct: 482 FQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQ 523
Score = 50.8 bits (120), Expect = 7e-06
Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 15/121 (12%)
Query: 31 TVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILI 90
T V +A QV+PS HQ L ++QQ QQ+ + Q+QQ+Q+ +
Sbjct: 421 TTMVGSAPSTQVSPSVQTQQ----HQMQLQ------QQQQQQQQQMQQMQQQQLQQHQMH 470
Query: 91 AEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE-KQHRE 149
+ Q+Q +Q QH Q +H++QQQ+ L + Q+ L+ Q L++ Q Q+L+ QH+
Sbjct: 471 QQIQQQMQQQHFQHHMQ--QHLQQQQQHLQQQINQQQLQQQ--LQQRLQLQQLQHMQHQS 526
Query: 150 Q 150
Q
Sbjct: 527 Q 527
Score = 47.4 bits (111), Expect = 7e-05
Identities = 58/239 (24%), Positives = 106/239 (44%), Gaps = 31/239 (12%)
Query: 368 AGQQDAERLTLPALQQRLSLFPGTHLTP-YLSTSPLERDGGAAHSP-LLQHMVLLEQPPA 425
A + AE T+ ++QQ L+ T+LT L +PL + G + SP LQ L + A
Sbjct: 330 AAAESAEAQTIRSVQQTLA---STNLTSSLLLNTPLSQHGTVSASPQTLQQS--LPRSIA 384
Query: 426 QAPLVTGLGALPLHAQSLVGADRVS----PSIHKLRQHRPLGRTQSAPLPQNAQALQHLV 481
PL L + + A+ S P I + +G S + + Q QH +
Sbjct: 385 PKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTM-VGSAPSTQVSPSVQTQQHQM 443
Query: 482 IQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYL 541
QQ QQ ++ QQ QQQQLQ +++ + + +Q + ++ L++ Q +L
Sbjct: 444 QLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQ-QHFQHHMQQHLQQQQ-----QHL 497
Query: 542 DRLPGQKEAHAQAGVQVKQEPIESDEEEAEP-PREVEP------------GQRQPSEQE 587
+ Q++ Q +++ + ++ + +++P PR+ P G QP+ Q+
Sbjct: 498 QQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQ 556
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/79 (26%), Positives = 48/79 (60%), Gaps = 6/79 (7%)
Query: 101 SRQHEAQLHEHIKQQQEMLAMKHQQELLEHQ--RKLERHRQEQELEKQHREQKLQQLKNK 158
++QH+ QL + +QQQ+ + QQ+L +HQ +++++ Q+Q + H +Q LQQ +
Sbjct: 438 TQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQ-HHMQQHLQQ---Q 493
Query: 159 EKGKESAVASTEVKMKLQE 177
++ + + +++ +LQ+
Sbjct: 494 QQHLQQQINQQQLQQQLQQ 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,902,131
Number of Sequences: 37866
Number of extensions: 2464194
Number of successful extensions: 23360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 303
Number of HSP's successfully gapped in prelim test: 968
Number of HSP's that attempted gapping in prelim test: 11742
Number of HSP's gapped (non-prelim): 7231
length of query: 1084
length of database: 18,247,518
effective HSP length: 113
effective length of query: 971
effective length of database: 13,968,660
effective search space: 13563568860
effective search space used: 13563568860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.