Search of human proteins with 153070254

Search of human proteins with 153070254

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153070254 MAGI family member, X-linked isoform b [Homo
sapiens]
         (262 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]    533   e-152
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]    487   e-138
gi|153070256 MAGI family member, X-linked isoform d [Homo sapiens]    337   6e-93
gi|153070252 MAGI family member, X-linked isoform c [Homo sapiens]    331   4e-91
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    96   3e-20
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    87   1e-17
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    87   1e-17
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    85   7e-17
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    79   4e-15
gi|155969695 membrane-associated guanylate kinase-related  3 iso...    79   4e-15
gi|116875765 tight junction protein 1 isoform b [Homo sapiens]         62   4e-10
gi|116875767 tight junction protein 1 isoform a [Homo sapiens]         62   4e-10
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    62   4e-10
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]             62   5e-10
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]              61   1e-09
gi|148612825 Rap GTPase interactor [Homo sapiens]                      60   2e-09
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]              60   2e-09
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]              60   2e-09
gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]              60   2e-09
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    59   4e-09
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    59   4e-09
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    59   4e-09
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      58   7e-09
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       58   7e-09
gi|157388993 synaptojanin 2 binding protein [Homo sapiens]             58   1e-08
gi|87196343 PDZ domain containing 2 [Homo sapiens]                     57   2e-08
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    56   3e-08
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    56   4e-08
gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                   56   4e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      56   4e-08

>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
          Length = 262

 Score =  533 bits (1374), Expect = e-152
 Identities = 262/262 (100%), Positives = 262/262 (100%)

Query: 1   MSPNSPLHCFYLPAVSVLDSADIEVTDSRLPHATIVDHRPQGKARSAPKPSQASGHFSVE 60
           MSPNSPLHCFYLPAVSVLDSADIEVTDSRLPHATIVDHRPQGKARSAPKPSQASGHFSVE
Sbjct: 1   MSPNSPLHCFYLPAVSVLDSADIEVTDSRLPHATIVDHRPQGKARSAPKPSQASGHFSVE 60

Query: 61  LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 120
           LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH
Sbjct: 61  LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 120

Query: 121 AQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSL 180
           AQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSL
Sbjct: 121 AQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSL 180

Query: 181 VQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLS 240
           VQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLS
Sbjct: 181 VQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLS 240

Query: 241 RALGVRGAAQLAQEMAAGRRRH 262
           RALGVRGAAQLAQEMAAGRRRH
Sbjct: 241 RALGVRGAAQLAQEMAAGRRRH 262


>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
          Length = 334

 Score =  487 bits (1254), Expect = e-138
 Identities = 249/269 (92%), Positives = 249/269 (92%), Gaps = 20/269 (7%)

Query: 14  AVSVLDSADIEVTDSRLPHATIVDHRPQ---------------GKARSAPKPSQASGHFS 58
           AVSVLDSADIEVTDSRLPHATIVDHRPQ               GKARSAPKPSQASGHFS
Sbjct: 66  AVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHFS 125

Query: 59  VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
           VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL
Sbjct: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185

Query: 119 THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV-----DRSPDPGGPEVTGS 173
           THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV     DRSPDPGGPEVTGS
Sbjct: 186 THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS 245

Query: 174 RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV 233
           RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV
Sbjct: 246 RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV 305

Query: 234 PSEERLSRALGVRGAAQLAQEMAAGRRRH 262
           PSEERLSRALGVRGAAQLAQEMAAGRRRH
Sbjct: 306 PSEERLSRALGVRGAAQLAQEMAAGRRRH 334


>gi|153070256 MAGI family member, X-linked isoform d [Homo sapiens]
          Length = 253

 Score =  337 bits (864), Expect = 6e-93
 Identities = 182/249 (73%), Positives = 183/249 (73%), Gaps = 61/249 (24%)

Query: 14  AVSVLDSADIEVTDSRLPHATIVDHRPQGKARSAPKPSQASGHFSVELVRGYAGFGLTLG 73
           AVSVLDSADIEVTDSRLPHATIVDHRPQ                                
Sbjct: 66  AVSVLDSADIEVTDSRLPHATIVDHRPQ-------------------------------- 93

Query: 74  GGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQ 133
                 GD  L + G                        ESTQGLTHAQAVERIRAGGPQ
Sbjct: 94  -----VGDLVLHING------------------------ESTQGLTHAQAVERIRAGGPQ 124

Query: 134 LHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKT 193
           LHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKT
Sbjct: 125 LHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKT 184

Query: 194 RGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQ 253
           RGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQ
Sbjct: 185 RGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQ 244

Query: 254 EMAAGRRRH 262
           EMAAGRRRH
Sbjct: 245 EMAAGRRRH 253


>gi|153070252 MAGI family member, X-linked isoform c [Homo sapiens]
          Length = 258

 Score =  331 bits (848), Expect = 4e-91
 Identities = 182/254 (71%), Positives = 183/254 (72%), Gaps = 66/254 (25%)

Query: 14  AVSVLDSADIEVTDSRLPHATIVDHRPQGKARSAPKPSQASGHFSVELVRGYAGFGLTLG 73
           AVSVLDSADIEVTDSRLPHATIVDHRPQ                                
Sbjct: 66  AVSVLDSADIEVTDSRLPHATIVDHRPQ-------------------------------- 93

Query: 74  GGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQ 133
                 GD  L + G                        ESTQGLTHAQAVERIRAGGPQ
Sbjct: 94  -----VGDLVLHING------------------------ESTQGLTHAQAVERIRAGGPQ 124

Query: 134 LHLVIRRPLETHPGKPRGVGEPRKGV-----DRSPDPGGPEVTGSRSSSTSLVQHPPSRT 188
           LHLVIRRPLETHPGKPRGVGEPRKGV     DRSPDPGGPEVTGSRSSSTSLVQHPPSRT
Sbjct: 125 LHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRT 184

Query: 189 TLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGA 248
           TLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGA
Sbjct: 185 TLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGA 244

Query: 249 AQLAQEMAAGRRRH 262
           AQLAQEMAAGRRRH
Sbjct: 245 AQLAQEMAAGRRRH 258


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 95.9 bits (237), Expect = 3e-20
 Identities = 73/219 (33%), Positives = 105/219 (47%), Gaps = 49/219 (22%)

Query: 47   APKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDL 106
            AP+ +Q    ++VEL RG  GFG +L GGR+   D  L V  L +DGPA+RCG++ +GD 
Sbjct: 1112 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPAERCGKMRIGDE 1169

Query: 107  VLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR---------PLETHPGK---PRGVGE 154
            +L INGE+T+ + H++A+E I+ GG ++ L ++R         P     G    P+GV E
Sbjct: 1170 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPE 1229

Query: 155  PRKGVDRSPDPG---------------------GPEVTGSRSSSTSLVQHPP-SRTTLKK 192
             R G DR   P                        +  GSR  S    +H   + T+ K 
Sbjct: 1230 VRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKP 1289

Query: 193  TRGSPEP---SPE----------AAADGPTVSPPERRAE 218
              G+  P   +PE          AAA+GP    PE+R E
Sbjct: 1290 DSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRRE 1328



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)

Query: 41  QGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCG 99
           QGK      PS+  G F   +L +   GFG T+ GG +   D  L ++ L+ DGPA   G
Sbjct: 454 QGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALDG 511

Query: 100 RLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 149
           ++E GD+++ +N     G THAQ V+  ++        L L    PL   P  P
Sbjct: 512 KMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 40/158 (25%), Positives = 65/158 (41%), Gaps = 31/158 (19%)

Query: 57   FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 105
            + VE+ RG   GFG  +     R  AG T        P  +  +++  PA RCG+L+VGD
Sbjct: 969  YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028

Query: 106  LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDP 165
             +L +NG S    +H+  V  I+  G  + L I                    +      
Sbjct: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI--------------------IPGDESS 1068

Query: 166  GGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 203
                +T +   +T    H PS+   ++TR + +P  E+
Sbjct: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1106



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           +V +V+G  GFG T+    D  G     V+ ++ D P  RC  L+ GDL++ +N ++ Q 
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696

Query: 118 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           LTH Q V+ +     G ++ L+++R          G+  P+K    SP     E   S++
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR---------GGLPVPKK----SPKSQPLERKDSQN 743

Query: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPGPWLVP 234
           SS   V    S  T      SP  S +   + P   P E +A D  D      P P+ + 
Sbjct: 744 SSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPDPFKIW 795

Query: 235 SEER 238
           ++ R
Sbjct: 796 AQSR 799


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 42/94 (44%), Positives = 65/94 (69%), Gaps = 2/94 (2%)

Query: 47   APKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDL 106
            AP+ +Q    ++VEL RG  GFG +L GGR+   D  L V  L +DGPA+RCG++ +GD 
Sbjct: 1141 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPAERCGKMRIGDE 1198

Query: 107  VLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            +L INGE+T+ + H++A+E I+ GG ++ L ++R
Sbjct: 1199 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)

Query: 41  QGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCG 99
           QGK      PS+  G F   +L +   GFG T+ GG +   D  L ++ L+ DGPA   G
Sbjct: 454 QGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALDG 511

Query: 100 RLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 149
           ++E GD+++ +N     G THAQ V+  ++        L L    PL   P  P
Sbjct: 512 KMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 40/159 (25%), Positives = 65/159 (40%), Gaps = 32/159 (20%)

Query: 57   FSVELVRGY-AGFGLTLGGG--RDVAGDT---------PLAVRGLLKDGPAQRCGRLEVG 104
            + VE+ RG   GFG  +     R  AG T         P  +  +++  PA RCG+L+VG
Sbjct: 997  YDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVG 1056

Query: 105  DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPD 164
            D +L +NG S    +H+  V  I+  G  + L I                    +     
Sbjct: 1057 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI--------------------IPGDES 1096

Query: 165  PGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 203
                 +T +   +T    H PS+   ++TR + +P  E+
Sbjct: 1097 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1135



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           +V +V+G  GFG T+    D  G     V+ ++ D P  RC  L+ GDL++ +N ++ Q 
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696

Query: 118 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           LTH Q V+ +     G ++ L+++R          G+  P+K    SP     E   S++
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR---------GGLPVPKK----SPKSQPLERKDSQN 743

Query: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPGPWLVP 234
           SS   V    S  T      SP  S +   + P   P E +A D  D      P P+ + 
Sbjct: 744 SSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPDPFKIW 795

Query: 235 SEER 238
           ++ R
Sbjct: 796 AQSR 799


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 42/94 (44%), Positives = 65/94 (69%), Gaps = 2/94 (2%)

Query: 47   APKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDL 106
            AP+ +Q    ++VEL RG  GFG +L GGR+   D  L V  L +DGPA+RCG++ +GD 
Sbjct: 1140 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPAERCGKMRIGDE 1197

Query: 107  VLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            +L INGE+T+ + H++A+E I+ GG ++ L ++R
Sbjct: 1198 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)

Query: 41  QGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCG 99
           QGK      PS+  G F   +L +   GFG T+ GG +   D  L ++ L+ DGPA   G
Sbjct: 454 QGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALDG 511

Query: 100 RLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 149
           ++E GD+++ +N     G THAQ V+  ++        L L    PL   P  P
Sbjct: 512 KMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 40/158 (25%), Positives = 65/158 (41%), Gaps = 31/158 (19%)

Query: 57   FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 105
            + VE+ RG   GFG  +     R  AG T        P  +  +++  PA RCG+L+VGD
Sbjct: 997  YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056

Query: 106  LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDP 165
             +L +NG S    +H+  V  I+  G  + L I                    +      
Sbjct: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI--------------------IPGDESS 1096

Query: 166  GGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 203
                +T +   +T    H PS+   ++TR + +P  E+
Sbjct: 1097 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1134



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           +V +V+G  GFG T+    D  G     V+ ++ D P  RC  L+ GDL++ +N ++ Q 
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696

Query: 118 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           LTH Q V+ +     G ++ L+++R          G+  P+K    SP     E   S++
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR---------GGLPVPKK----SPKSQPLERKDSQN 743

Query: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPGPWLVP 234
           SS   V    S  T      SP  S +   + P   P E +A D  D      P P+ + 
Sbjct: 744 SSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPDPFKIW 795

Query: 235 SEER 238
           ++ R
Sbjct: 796 AQSR 799


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 84.7 bits (208), Expect = 7e-17
 Identities = 67/209 (32%), Positives = 99/209 (47%), Gaps = 40/209 (19%)

Query: 56   HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
            +F+V++ +G  GFG ++ GGR+   D  L V  L +DGPA R GR+ VGD ++ INGEST
Sbjct: 1145 YFTVDMEKGAKGFGFSIRGGREYKMD--LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202

Query: 116  QGLTHAQAVERIRAGGPQLHLVIRRPLETHP--GKPRGVGEPRKGVDRSPDPGGPEVTGS 173
            + +THA+A+E I++GG ++ L+++R     P   +P     P         PG PEV   
Sbjct: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAA-----PGLPEV--G 1255

Query: 174  RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGP-WL 232
             S    L    PS            P+P +               DP+ QI  SPGP W 
Sbjct: 1256 VSLDDGLAPFSPS-----------HPAPPS---------------DPSHQI--SPGPTWD 1287

Query: 233  VPSEERLSRALGVRGAAQLAQEMAAGRRR 261
            +  E  + +   +    Q  Q +   R R
Sbjct: 1288 IKREHDVRKPKELSACGQKKQRLGEQRER 1316



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 41/120 (34%), Positives = 61/120 (50%), Gaps = 7/120 (5%)

Query: 51  SQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLH 109
           SQ  G F S  L +   GFG T+ GG +   D  L V+ ++ DGPA + G++E GD++++
Sbjct: 418 SQLKGTFLSTTLKKSNMGFGFTIIGGDEP--DEFLQVKSVIPDGPAAQDGKMETGDVIVY 475

Query: 110 INGESTQGLTHAQAVERIRAG--GPQLHLVIRR--PLETHPGKPRGVGEPRKGVDRSPDP 165
           IN     G THA  V+  ++   G  ++LV+ R  PL   P  P     P   +   P P
Sbjct: 476 INEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPP 535



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)

Query: 67   GFGLTLGGGRDVAGDT---PLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQA 123
            GF +     R  +G T   P  +  ++   PA RC +L+VGD +L +NG+S   + HA  
Sbjct: 932  GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI 991

Query: 124  VERIRAGGPQLHLVI 138
            V+ I+  G  + L I
Sbjct: 992  VKLIKDAGLSVTLRI 1006



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 11/107 (10%)

Query: 59  VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
           V L R  +GFG  + GG D  G  P+ +  ++  G A R GRL  GD +++++G    G 
Sbjct: 779 VHLRRMESGFGFRILGG-DEPGQ-PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836

Query: 119 THAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSP 163
           TH   ++ +   A   Q++L +RR       K    GEP     RSP
Sbjct: 837 THRYVIDLMHHAARNGQVNLTVRR-------KVLCGGEPCPENGRSP 876



 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 35/131 (26%), Positives = 62/131 (47%), Gaps = 15/131 (11%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           ++ +V+G  GFG T+        D+P   R + +    Q C  L  GDL++ IN ++ Q 
Sbjct: 605 TLTIVKGAQGFGFTIA-------DSPTGQR-VKQILDIQGCPGLCEGDLIVEINQQNVQN 656

Query: 118 LTHAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           L+H + V+ ++    G +  L+I R     P K      P+  +DR  + G P+ + S  
Sbjct: 657 LSHTEVVDILKDCPIGSETSLIIHRGGFFSPWK-----TPKPIMDRWENQGSPQTSLSAP 711

Query: 176 SSTSLVQHPPS 186
           +    +  PP+
Sbjct: 712 AIPQNLPFPPA 722



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 44/176 (25%), Positives = 58/176 (32%), Gaps = 43/176 (24%)

Query: 72   LGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGG 131
            LG  R+ +     A R  L++ P  + GR E G            GL  A A +  RAGG
Sbjct: 1310 LGEQRERSASPQRAARPRLEEAPGGQ-GRPEAGRPASEARAP---GLAAADAADAARAGG 1365

Query: 132  PQLHLVIRRPLETHPGKPRGVGEP----RKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSR 187
             +               PR         R+G   +P   GP   GS +            
Sbjct: 1366 KEA--------------PRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAE-------- 1403

Query: 188  TTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRAL 243
                  R  P P P      P    P R+A         +PGPW VP  ++L   L
Sbjct: 1404 -GRAGARAGPRPGPR-----PPGGAPARKAAV-------APGPWKVPGSDKLPSVL 1446


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score = 79.0 bits (193), Expect = 4e-15
 Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)

Query: 51   SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 110
            +Q  G + VEL RG  GFG +L GG++   +  L +  L +DGPA + GR+ VGD ++ I
Sbjct: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071

Query: 111  NGESTQGLTHAQAVERIRAGGPQLHLVIR 139
            NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)

Query: 43  KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 101
           K+     PSQ  G      L +   GFG T+ GG     D  L V+ +LKDGPA + G++
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451

Query: 102 EVGDLVLHINGESTQGLTHAQAVE 125
             GD+++ ING    G THA  V+
Sbjct: 452 APGDVIVDINGNCVLGHTHADVVQ 475



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 33/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)

Query: 67  GFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 126
           GF +     +   G  P  +  +++  PA RCG+L+VGD +  +NG+S   L+H   V+ 
Sbjct: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922

Query: 127 IRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGP----EVTGSRSS 176
           I+  G  + L +    E H G P G    R+       P G      + G RS+
Sbjct: 923 IKDAGVTVTLTVIAE-EEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSA 975



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 8/71 (11%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           ++ L++G  GFG  +         T   V+ +L    +Q C  L+ GD++  I  ++ Q 
Sbjct: 578 TIPLIKGPKGFGFAIADS-----PTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQN 629

Query: 118 LTHAQAVERIR 128
           LTH Q VE ++
Sbjct: 630 LTHLQVVEVLK 640



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 66  AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
           +GFG  + GG     D  + +  ++  G A++ GRL   D ++ I+G   +G +H Q ++
Sbjct: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791

Query: 126 RIRAGGPQLH--LVIRRPL 142
            +       H  L +RR +
Sbjct: 792 LMTTAARNGHVLLTVRRKI 810



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 27/103 (26%), Positives = 38/103 (36%), Gaps = 7/103 (6%)

Query: 143  ETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPE 202
            E   GK    GE       S D  G  V   + S   L Q P  +    KT        E
Sbjct: 1381 ENEKGKKVTTGE----TSSSNDKIGENV---QLSEKRLKQEPEEKVVSNKTEDHKGKELE 1433

Query: 203  AAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGV 245
            AA         +  +  P  +   +PGPW VPS  +++  +G+
Sbjct: 1434 AADKNKETGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGM 1476


>gi|155969695 membrane-associated guanylate kinase-related  3 isoform
            2 [Homo sapiens]
          Length = 1125

 Score = 79.0 bits (193), Expect = 4e-15
 Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)

Query: 51   SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 110
            +Q  G + VEL RG  GFG +L GG++   +  L +  L +DGPA + GR+ VGD ++ I
Sbjct: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071

Query: 111  NGESTQGLTHAQAVERIRAGGPQLHLVIR 139
            NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)

Query: 43  KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 101
           K+     PSQ  G      L +   GFG T+ GG     D  L V+ +LKDGPA + G++
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451

Query: 102 EVGDLVLHINGESTQGLTHAQAVE 125
             GD+++ ING    G THA  V+
Sbjct: 452 APGDVIVDINGNCVLGHTHADVVQ 475



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 33/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)

Query: 67  GFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 126
           GF +     +   G  P  +  +++  PA RCG+L+VGD +  +NG+S   L+H   V+ 
Sbjct: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922

Query: 127 IRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGP----EVTGSRSS 176
           I+  G  + L +    E H G P G    R+       P G      + G RS+
Sbjct: 923 IKDAGVTVTLTVIAE-EEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSA 975



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 8/71 (11%)

Query: 58  SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
           ++ L++G  GFG  +         T   V+ +L    +Q C  L+ GD++  I  ++ Q 
Sbjct: 578 TIPLIKGPKGFGFAIADS-----PTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQN 629

Query: 118 LTHAQAVERIR 128
           LTH Q VE ++
Sbjct: 630 LTHLQVVEVLK 640



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 66  AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
           +GFG  + GG     D  + +  ++  G A++ GRL   D ++ I+G   +G +H Q ++
Sbjct: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791

Query: 126 RIRAGGPQLH--LVIRRPL 142
            +       H  L +RR +
Sbjct: 792 LMTTAARNGHVLLTVRRKI 810


>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
          Length = 1668

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 44/156 (28%), Positives = 69/156 (44%), Gaps = 14/156 (8%)

Query: 67  GFGLTLGGGRD----VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
           GFG+ + GGRD     +G+T + +  +LK GPA+  G+L+  D V  +NG S   + HA 
Sbjct: 33  GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90

Query: 123 AVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQ 182
           AV+++R  G    + IRR  +     P    +P    D   D    E+   RS  + +V 
Sbjct: 91  AVQQLRKSGKNAKITIRRKKKVQ--IPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVN 148

Query: 183 H------PPSRTTLKKTRGSPEPSPEAAADGPTVSP 212
                  P  R+  ++   SP     + A      P
Sbjct: 149 RRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKP 184



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 34/228 (14%)

Query: 19  DSADIEVTDSRLPHATIVDHRPQG---KARSAPKP--------------SQASGHFSVEL 61
           DS D E+ D R   + +V+ R +    + RSA +               SQ +    V L
Sbjct: 130 DSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTL 189

Query: 62  VRGYAG--FGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLT 119
           V+      +GL L         + + V+ + +D  A R G ++ GD+VL ING  T+ ++
Sbjct: 190 VKSRKNEEYGLRLA--------SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241

Query: 120 HAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSS-ST 178
              A   I     +L +V++R           + +     + S      E+    S  S 
Sbjct: 242 LTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSG 301

Query: 179 SLVQHPPSRTTLKKTRGSPEP------SPEAAADGPTVSPPERRAEDP 220
                PP R+  +      EP      SP+  ++G   S  E R   P
Sbjct: 302 RSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKP 349


>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
          Length = 1748

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 44/156 (28%), Positives = 69/156 (44%), Gaps = 14/156 (8%)

Query: 67  GFGLTLGGGRD----VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
           GFG+ + GGRD     +G+T + +  +LK GPA+  G+L+  D V  +NG S   + HA 
Sbjct: 33  GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90

Query: 123 AVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSSSTSLVQ 182
           AV+++R  G    + IRR  +     P    +P    D   D    E+   RS  + +V 
Sbjct: 91  AVQQLRKSGKNAKITIRRKKKVQ--IPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVN 148

Query: 183 H------PPSRTTLKKTRGSPEPSPEAAADGPTVSP 212
                  P  R+  ++   SP     + A      P
Sbjct: 149 RRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKP 184



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 34/228 (14%)

Query: 19  DSADIEVTDSRLPHATIVDHRPQG---KARSAPKP--------------SQASGHFSVEL 61
           DS D E+ D R   + +V+ R +    + RSA +               SQ +    V L
Sbjct: 130 DSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTL 189

Query: 62  VRGYAG--FGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLT 119
           V+      +GL L         + + V+ + +D  A R G ++ GD+VL ING  T+ ++
Sbjct: 190 VKSRKNEEYGLRLA--------SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241

Query: 120 HAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRSS-ST 178
              A   I     +L +V++R           + +     + S      E+    S  S 
Sbjct: 242 LTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSG 301

Query: 179 SLVQHPPSRTTLKKTRGSPEP------SPEAAADGPTVSPPERRAEDP 220
                PP R+  +      EP      SP+  ++G   S  E R   P
Sbjct: 302 RSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKP 349


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 58/182 (31%), Positives = 84/182 (46%), Gaps = 17/182 (9%)

Query: 57  FSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQ 116
           ++VEL R     G+T+ G  +     P+ + GL K G A+R G + VGD +L IN  S +
Sbjct: 753 YTVELKRYGGPLGITISGTEEPFD--PIVISGLTKRGLAERTGAIHVGDRILAINNVSLK 810

Query: 117 GLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDP------GGPEV 170
           G   ++A+  ++  G  + L I++ L+  P  PR  G   +  D   DP      G P  
Sbjct: 811 GRPLSEAIHLLQVAGETVTLKIKKQLD-RPLLPRKSGSLSETSDADEDPADALKGGLPAA 869

Query: 171 TGSRS--SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSP 228
             S +  S  S V+   S  T     G    +P+AAA G T  P ERR       + GSP
Sbjct: 870 RFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTT--PQERRP----GWLRGSP 923

Query: 229 GP 230
            P
Sbjct: 924 PP 925



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 29/66 (43%), Positives = 39/66 (59%), Gaps = 4/66 (6%)

Query: 66  AGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
           +GFGL L GG    +     PL V  +  D PA+RCG L+VGD VL ING +T+  T  +
Sbjct: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621

Query: 123 AVERIR 128
           A + +R
Sbjct: 622 ANQLLR 627



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 2/81 (2%)

Query: 50  PSQASGHFSVELVRGYAGFGLTLGGGRDVAG--DTPLAVRGLLKDGPAQRCGRLEVGDLV 107
           P   S    V L +    FG  L GG    G    PL +  +   GPA R G L+VGD +
Sbjct: 237 PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296

Query: 108 LHINGESTQGLTHAQAVERIR 128
           L ++G    G +HA A+  +R
Sbjct: 297 LSVDGIPLHGASHATALATLR 317



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 3/94 (3%)

Query: 50  PSQASGHFSVELVRGYAG-FGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVL 108
           P +  G   VEL++      GLT+ GG D  G     V  L   G A R   L +GD + 
Sbjct: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKP--RVSNLRPGGLAARSDLLNIGDYIR 194

Query: 109 HINGESTQGLTHAQAVERIRAGGPQLHLVIRRPL 142
            +NG     L H + +  ++  G ++ L +   L
Sbjct: 195 SVNGIHLTRLRHDEIITLLKNVGERVVLEVEYEL 228


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 68/239 (28%), Positives = 106/239 (44%), Gaps = 48/239 (20%)

Query: 56  HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           ++SV LV G A +G  L GG+D   + PL +  L KDG       + +GD+VL I+G + 
Sbjct: 3   NYSVSLV-GPAPWGFRLQGGKDF--NMPLTISSL-KDGGKAAQANVRIGDVVLSIDGINA 58

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRR--------PLETHPGKPRGVGEP------------ 155
           QG+TH +A  +I+     L++ ++R        P+    G+P+ V +P            
Sbjct: 59  QGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVT 118

Query: 156 ---RKGVDRSPDPGG----PEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGP 208
                  +++P P G    P+VT   S S++     P+  T   T     PSP AA   P
Sbjct: 119 STNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFT---PAHAT---TSSHASPSPVAAVTPP 172

Query: 209 --TVSPPERRAEDPNDQIPG--SPGPWL--VPSEERLSRALGVRGAAQLAQEMAAGRRR 261
               S     A    DQ P   S G     VP +  ++        ++ +QE+A G+RR
Sbjct: 173 LFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSV-----CSETSQELAEGQRR 226


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 58/193 (30%), Positives = 86/193 (44%), Gaps = 27/193 (13%)

Query: 61  LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 120
           ++ G A +G  L GG+D   + PL++  L   G A + G + VGD VL I+GE+   LTH
Sbjct: 7   VLEGPAPWGFRLQGGKDF--NVPLSISRLTPGGKAAQAG-VAVGDWVLSIDGENAGSLTH 63

Query: 121 AQAVERIRAGGPQLHLVIRR--PLETHPGK----------PRGVGEPRKGVDRSPDPGGP 168
            +A  +IRA G +L L + R  P+++ P K          P      ++ +  + +   P
Sbjct: 64  IEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTEDWRP 123

Query: 169 EVTGSRSSSTSLVQH--------PPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDP 220
                +S S  ++ H         P    LKK+  S  P  EA A  P  S P+     P
Sbjct: 124 RPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKS--SQVPRTEAPA--PASSTPQEPWPGP 179

Query: 221 NDQIPGSPGPWLV 233
               P S  PW V
Sbjct: 180 TAPSPTSRPPWAV 192


>gi|148612825 Rap GTPase interactor [Homo sapiens]
          Length = 1075

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 42/108 (38%), Positives = 57/108 (52%), Gaps = 9/108 (8%)

Query: 46   SAPKPSQASGH-------FSVELVRGYAGFGLTLGGGRDV-AGDTPLAVRGLLKDGPAQR 97
            S P PS  S         F+VEL RG +G G+ L  G     G   L ++ LL   PA  
Sbjct: 957  SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016

Query: 98   CGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLH-LVIRRPLET 144
             GRL +GD +L +NG S  GL + +AV+ IR GG ++  LV +  +ET
Sbjct: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVET 1064


>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
          Length = 278

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 56/183 (30%), Positives = 83/183 (45%), Gaps = 22/183 (12%)

Query: 62  VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 121
           V G A +G  + GGRD    TP+ V  + + G A+    L  GD+++ INGES +G+ HA
Sbjct: 7   VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 122 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGS----RSSS 177
           +A  +IR     L L + R   T PG+  G        D S +       GS      S 
Sbjct: 64  EAQSKIRQSPSPLRLQLDRSQATSPGQTNG--------DSSLEVLATRFQGSVRTYTESQ 115

Query: 178 TSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEE 237
           +SL     S T+L    GSP   P +++     +   R  +     +  SPG   +P+ +
Sbjct: 116 SSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG---LPAAD 168

Query: 238 RLS 240
           RLS
Sbjct: 169 RLS 171


>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
          Length = 366

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 56/183 (30%), Positives = 83/183 (45%), Gaps = 22/183 (12%)

Query: 62  VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 121
           V G A +G  + GGRD    TP+ V  + + G A+    L  GD+++ INGES +G+ HA
Sbjct: 7   VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 122 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGS----RSSS 177
           +A  +IR     L L + R   T PG+  G        D S +       GS      S 
Sbjct: 64  EAQSKIRQSPSPLRLQLDRSQATSPGQTNG--------DSSLEVLATRFQGSVRTYTESQ 115

Query: 178 TSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEE 237
           +SL     S T+L    GSP   P +++     +   R  +     +  SPG   +P+ +
Sbjct: 116 SSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG---LPAAD 168

Query: 238 RLS 240
           RLS
Sbjct: 169 RLS 171


>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
          Length = 352

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 56/183 (30%), Positives = 83/183 (45%), Gaps = 22/183 (12%)

Query: 62  VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 121
           V G A +G  + GGRD    TP+ V  + + G A+    L  GD+++ INGES +G+ HA
Sbjct: 7   VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63

Query: 122 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGS----RSSS 177
           +A  +IR     L L + R   T PG+  G        D S +       GS      S 
Sbjct: 64  EAQSKIRQSPSPLRLQLDRSQATSPGQTNG--------DSSLEVLATRFQGSVRTYTESQ 115

Query: 178 TSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEE 237
           +SL     S T+L    GSP   P +++     +   R  +     +  SPG   +P+ +
Sbjct: 116 SSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG---LPAAD 168

Query: 238 RLS 240
           RLS
Sbjct: 169 RLS 171


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)

Query: 46   SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 104
            S PKP      F VEL +     G+++ GG + +     + V+ ++  G A+  GR+  G
Sbjct: 1168 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1224

Query: 105  DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            D VL +NG S +G TH QAVE +R  G  +HL++ +
Sbjct: 1225 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1260



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 13/124 (10%)

Query: 31   PHATIVDHRPQGKA-RSAPKPSQASGH--------FSVELVRGYAGFGLTLGGGRDVAGD 81
            P  T+ D   QG+      K +Q   +        F V+L +  +G G +     ++  +
Sbjct: 1274 PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPE 1333

Query: 82   ----TPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLV 137
                + + V+ L    PA   G+++VGD++L +NG S +GL+  + +  +R   P++ L+
Sbjct: 1334 QINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL 1393

Query: 138  IRRP 141
            + RP
Sbjct: 1394 LCRP 1397



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)

Query: 63   RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
            +G  GF +T G  R         V  +++D PA+  GRL+ GD ++ +N      +TH  
Sbjct: 1605 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1658

Query: 123  AVERIRAGGPQLHLVIRRPLE 143
            AV  +RA    + LVI R LE
Sbjct: 1659 AVNLLRAASKTVRLVIGRVLE 1679



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)

Query: 67  GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
           G G  + GG  +   D  + +  +   GPA   G L+ GD ++ +N  S +G++H  A+E
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971

Query: 126 RIRAGGPQLHLVIRRPLE 143
            ++     + LVI +P E
Sbjct: 972 ILQNAPEDVTLVISQPKE 989



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 12/111 (10%)

Query: 99   GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPR-GVGEPR 156
            G L++ D++ ++NG STQG+T  +    +    P L L   R  L   P   R  V  P+
Sbjct: 1732 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1791

Query: 157  KGVDRSPDPGG----PEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 197
                      G    P +T + S ST      + + +P  + +  + +GSP
Sbjct: 1792 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 1842


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)

Query: 46   SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 104
            S PKP      F VEL +     G+++ GG + +     + V+ ++  G A+  GR+  G
Sbjct: 1359 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1415

Query: 105  DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            D VL +NG S +G TH QAVE +R  G  +HL++ +
Sbjct: 1416 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1451



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 13/124 (10%)

Query: 31   PHATIVDHRPQGKA-RSAPKPSQASGH--------FSVELVRGYAGFGLTLGGGRDVAGD 81
            P  T+ D   QG+      K +Q   +        F V+L +  +G G +     ++  +
Sbjct: 1465 PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPE 1524

Query: 82   ----TPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLV 137
                + + V+ L    PA   G+++VGD++L +NG S +GL+  + +  +R   P++ L+
Sbjct: 1525 QINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL 1584

Query: 138  IRRP 141
            + RP
Sbjct: 1585 LCRP 1588



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)

Query: 63   RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
            +G  GF +T G  R         V  +++D PA+  GRL+ GD ++ +N      +TH  
Sbjct: 1796 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1849

Query: 123  AVERIRAGGPQLHLVIRRPLE 143
            AV  +RA    + LVI R LE
Sbjct: 1850 AVNLLRAASKTVRLVIGRVLE 1870



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)

Query: 67   GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
            G G  + GG  +   D  + +  +   GPA   G L+ GD ++ +N  S +G++H  A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 126  RIRAGGPQLHLVIRRPLE 143
             ++     + LVI +P E
Sbjct: 1163 ILQNAPEDVTLVISQPKE 1180



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 12/111 (10%)

Query: 99   GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPR-GVGEPR 156
            G L++ D++ ++NG STQG+T  +    +    P L L   R  L   P   R  V  P+
Sbjct: 1923 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1982

Query: 157  KGVDRSPDPGG----PEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 197
                      G    P +T + S ST      + + +P  + +  + +GSP
Sbjct: 1983 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2033


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)

Query: 46   SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 104
            S PKP      F VEL +     G+++ GG + +     + V+ ++  G A+  GR+  G
Sbjct: 1340 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1396

Query: 105  DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            D VL +NG S +G TH QAVE +R  G  +HL++ +
Sbjct: 1397 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1432



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 13/124 (10%)

Query: 31   PHATIVDHRPQGKA-RSAPKPSQASGH--------FSVELVRGYAGFGLTLGGGRDVAGD 81
            P  T+ D   QG+      K +Q   +        F V+L +  +G G +     ++  +
Sbjct: 1446 PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPE 1505

Query: 82   ----TPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLV 137
                + + V+ L    PA   G+++VGD++L +NG S +GL+  + +  +R   P++ L+
Sbjct: 1506 QINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL 1565

Query: 138  IRRP 141
            + RP
Sbjct: 1566 LCRP 1569



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)

Query: 63   RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
            +G  GF +T G  R         V  +++D PA+  GRL+ GD ++ +N      +TH  
Sbjct: 1777 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1830

Query: 123  AVERIRAGGPQLHLVIRRPLE 143
            AV  +RA    + LVI R LE
Sbjct: 1831 AVNLLRAASKTVRLVIGRVLE 1851



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)

Query: 67   GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
            G G  + GG  +   D  + +  +   GPA   G L+ GD ++ +N  S +G++H  A+E
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143

Query: 126  RIRAGGPQLHLVIRRPLE 143
             ++     + LVI +P E
Sbjct: 1144 ILQNAPEDVTLVISQPKE 1161



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 12/111 (10%)

Query: 99   GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPR-GVGEPR 156
            G L++ D++ ++NG STQG+T  +    +    P L L   R  L   P   R  V  P+
Sbjct: 1904 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1963

Query: 157  KGVDRSPDPGG----PEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 197
                      G    P +T + S ST      + + +P  + +  + +GSP
Sbjct: 1964 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2014


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 10/159 (6%)

Query: 59  VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           ++L +G  G G ++ GG   + + GD  + V  ++  G AQ+ GRL+VGD +L +N  S 
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           + +TH +AV  ++     ++L + +P   +   P G  +    +  S  P  P      S
Sbjct: 359 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD----ITHSYSP--PMENHLLS 412

Query: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 214
            +   +++  S   +   R SP P      D     PPE
Sbjct: 413 GNNGTLEYKTSLPPISPGRYSPIPK-HMLVDDDYTRPPE 450



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 3/85 (3%)

Query: 59  VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + L RG +G G ++ GG D   +  D  + +  ++  G A   GRL V D +L +N    
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRR 140
             ++H++AVE ++  G  + L +RR
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRR 288



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 59  VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
           V L +G  G G  + GG D  G   + V  +L  GPA   G L+ GD +L +NG   +G 
Sbjct: 527 VVLHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 583

Query: 119 THAQAVERIRAGGPQLHLV 137
           +H QA   ++  G  + ++
Sbjct: 584 SHEQAAAALKGAGQTVTII 602


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 10/159 (6%)

Query: 59  VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           ++L +G  G G ++ GG   + + GD  + V  ++  G AQ+ GRL+VGD +L +N  S 
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
           + +TH +AV  ++     ++L + +P   +   P G  +    +  S  P  P      S
Sbjct: 254 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD----ITHSYSP--PMENHLLS 307

Query: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 214
            +   +++  S   +   R SP P      D     PPE
Sbjct: 308 GNNGTLEYKTSLPPISPGRYSPIPK-HMLVDDDYTRPPE 345



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 3/85 (3%)

Query: 59  VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + L RG +G G ++ GG D   +  D  + +  ++  G A   GRL V D +L +N    
Sbjct: 99  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRR 140
             ++H++AVE ++  G  + L +RR
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRR 183



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 59  VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
           V L +G  G G  + GG D  G   + V  +L  GPA   G L+ GD +L +NG   +G 
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 478

Query: 119 THAQAVERIRAGGPQLHLV 137
           +H QA   ++  G  + ++
Sbjct: 479 SHEQAAAALKGAGQTVTII 497


>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
          Length = 145

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 5/102 (4%)

Query: 59  VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + L RG +G G  + GG D   V+ D+ + V  + ++G A   GRL+ GD +L +NG+  
Sbjct: 14  INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGK--PRGVGEP 155
           + L H  AV+  R  G  + L ++  L+   G    RG G+P
Sbjct: 74  KNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDP 115


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 34/85 (40%), Positives = 53/85 (62%), Gaps = 4/85 (4%)

Query: 59   VELVRGYAGFGLTLGGGRD-VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
            VE+++  AG GL+L GG+  V GD PL ++ + K G A++ G +E GD +L ING+   G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810

Query: 118  LTHAQAVERIRA--GGPQLHLVIRR 140
            L H  A   +++   GP + L+IR+
Sbjct: 2811 LMHFDAWNIMKSVPEGP-VQLLIRK 2834



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 1/83 (1%)

Query: 57  FSVELVRGYAGFGLTLGGGR-DVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + +EL++   G G+ + GGR        + V  + + G A R GRL +GD +L ING   
Sbjct: 333 WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392

Query: 116 QGLTHAQAVERIRAGGPQLHLVI 138
            GL+H +AV  +R+    + LV+
Sbjct: 393 VGLSHEEAVAILRSATGMVQLVV 415



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 25/68 (36%), Positives = 41/68 (60%), Gaps = 4/68 (5%)

Query: 67  GFGLTLGGGRD-VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAV- 124
           G G ++ GGRD + G   + V+ +  +G A   GRL+ GD +L +NG   +GLT  +A+ 
Sbjct: 596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH 655

Query: 125 --ERIRAG 130
             ++IR+G
Sbjct: 656 TFKQIRSG 663



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 15/101 (14%)

Query: 66   AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
            +G G ++ GG DV   + + V  +   G A + G +  GD +L +NG S  GL H   ++
Sbjct: 2631 SGLGFSVAGGTDVEPKS-ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLK 2689

Query: 126  RIRAGGPQLH---LVIRRPLETHPGKPRGVGEPRKGVDRSP 163
             +     QLH   LV+ +         +G+ +PR    + P
Sbjct: 2690 VLHQA--QLHKDALVVIK---------KGMDQPRPSARQEP 2719



 Score = 32.0 bits (71), Expect = 0.56
 Identities = 40/167 (23%), Positives = 71/167 (42%), Gaps = 18/167 (10%)

Query: 86  VRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQA---VERIRAGGPQLHLVIRR-- 140
           V  L K+ PA + G++ + D +L +NG+   G+  + A    E+   GG    +++RR  
Sbjct: 121 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK 180

Query: 141 --PLETHPGKPRGVGEPRKGVDRSPDPGGPEV-TGSRSSSTSLVQHPPSRTTLKKTRGSP 197
                T+ G      EP  G   + + G      G R+    ++  PP+    ++++GS 
Sbjct: 181 HKAHSTYNGNSSNSSEP--GETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSA 238

Query: 198 --EPSPEAAADGPTVSPPER------RAEDPNDQIPGSPGPWLVPSE 236
             E S + + +      PE       + E+  D +    GP L  SE
Sbjct: 239 GCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSE 285


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 26/90 (28%), Positives = 51/90 (56%), Gaps = 3/90 (3%)

Query: 59  VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           V L++G  G G ++ GG   + + GD  + +  +++ G AQ+ GRL++GD +L +N  + 
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETH 145
           Q + H +AV  ++     ++L + +P   H
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLH 316



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 3/85 (3%)

Query: 59  VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + L RG +G G ++ GG D   V  D  + +  ++  G A   GRL V D VL +N    
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRR 140
             + H++AVE ++  GP + LV+RR
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRR 216



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 4/84 (4%)

Query: 61  LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 120
           L +G  G G  + GG D  G   + V  +L  GPA   G L  GD +L +NG + +  TH
Sbjct: 389 LHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATH 445

Query: 121 AQAVERIRAGGPQLHLVIR-RPLE 143
            QA   ++  G  + +V + RP E
Sbjct: 446 EQAAAALKRAGQSVTIVAQYRPEE 469


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 34/101 (33%), Positives = 51/101 (50%), Gaps = 9/101 (8%)

Query: 46   SAPKPSQASGHFSVELVRGYAGFGLTL------GGGRDVAGDTPLAVRGLLKDGPAQRCG 99
            S PKP      F VEL +     G+++      GG         + V+ ++  G A+  G
Sbjct: 1359 SPPKPGDI---FEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDG 1415

Query: 100  RLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
            R+  GD VL +NG S +G TH QAVE +R  G  +HL++ +
Sbjct: 1416 RIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1456



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 13/124 (10%)

Query: 31   PHATIVDHRPQGKA-RSAPKPSQASGH--------FSVELVRGYAGFGLTLGGGRDVAGD 81
            P  T+ D   QG+      K +Q   +        F V+L +  +G G +     ++  +
Sbjct: 1470 PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPE 1529

Query: 82   ----TPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLV 137
                + + V+ L    PA   G+++VGD++L +NG S +GL+  + +  +R   P++ L+
Sbjct: 1530 QINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL 1589

Query: 138  IRRP 141
            + RP
Sbjct: 1590 LCRP 1593



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)

Query: 63   RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 122
            +G  GF +T G  R         V  +++D PA+  GRL+ GD ++ +N      +TH  
Sbjct: 1801 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1854

Query: 123  AVERIRAGGPQLHLVIRRPLE 143
            AV  +RA    + LVI R LE
Sbjct: 1855 AVNLLRAASKTVRLVIGRVLE 1875



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)

Query: 67   GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
            G G  + GG  +   D  + +  +   GPA   G L+ GD ++ +N  S +G++H  A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 126  RIRAGGPQLHLVIRRPLE 143
             ++     + LVI +P E
Sbjct: 1163 ILQNAPEDVTLVISQPKE 1180



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 12/111 (10%)

Query: 99   GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPR-GVGEPR 156
            G L++ D++ ++NG STQG+T  +    +    P L L   R  L   P   R  V  P+
Sbjct: 1928 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1987

Query: 157  KGVDRSPDPGG----PEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 197
                      G    P +T + S ST      + + +P  + +  + +GSP
Sbjct: 1988 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2038


>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 41/125 (32%), Positives = 62/125 (49%), Gaps = 18/125 (14%)

Query: 40  PQGKARSAPKPS---------------QASGHFSVELVRGYA-GFGLTLGGGRD-VAGDT 82
           P GKA    +P+               QAS   ++ L++G A G G ++ GG+D + G  
Sbjct: 183 PAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI 242

Query: 83  PLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIR-AGGPQLHLVIRRP 141
            + V+ +   G A   GRL+ GD +L +NGES  GLTH  A+++ + A    L L +R  
Sbjct: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302

Query: 142 LETHP 146
           L   P
Sbjct: 303 LTAPP 307



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 28/90 (31%), Positives = 50/90 (55%), Gaps = 3/90 (3%)

Query: 58   SVELVRGYAGFGLTLGGGR-DVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQ 116
            +V L +  AG G +L GG+  + GD PL +  + K   +++   ++ GD +L + G + Q
Sbjct: 1234 TVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQ 1293

Query: 117  GLTHAQAVERIRA--GGPQLHLVIRRPLET 144
            GLT  +A   I+A   GP   ++ R+ L++
Sbjct: 1294 GLTRFEAWNIIKALPDGPVTIVIRRKSLQS 1323



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 2/78 (2%)

Query: 66   AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
            AG G +L GG D+     + V  +  +G A + G ++ G+ VL ING+S +G TH  A+ 
Sbjct: 1122 AGLGFSLAGGADLENKV-ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALA 1180

Query: 126  RIR-AGGPQLHLVIRRPL 142
             +R A  P+  +++ R L
Sbjct: 1181 ILRQAREPRQAVIVTRKL 1198


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 3/96 (3%)

Query: 59  VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           ++L +G  G G ++ GG   + + GD  + V  ++  G AQ+ GRL+VGD +L +N  S 
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRG 151
           + +TH +AV  ++     ++L + +P   +   P G
Sbjct: 203 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYG 238



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 3/85 (3%)

Query: 59  VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
           + L RG +G G ++ GG D   +  D  + +  ++  G A   GRL V D +L +N    
Sbjct: 48  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 116 QGLTHAQAVERIRAGGPQLHLVIRR 140
             ++H++AVE ++  G  + L +RR
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRR 132



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 59  VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
           V L +G  G G  + GG D  G   + V  +L  GPA   G L+ GD +L +NG   +G 
Sbjct: 319 VVLHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 375

Query: 119 THAQAVERIRAGGPQLHLV 137
           +H QA   ++  G  + ++
Sbjct: 376 SHEQAAAALKGAGQTVTII 394


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,214,231
Number of Sequences: 37866
Number of extensions: 817766
Number of successful extensions: 5073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 498
Number of HSP's that attempted gapping in prelim test: 3878
Number of HSP's gapped (non-prelim): 1564
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.