Search of human proteins with 148727288

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
         (1613 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148727288 low density lipoprotein receptor-related protein 6 ...  3350   0.0  
gi|119709832 low density lipoprotein receptor-related protein 5 ...  2366   0.0  
gi|157384998 low density lipoprotein receptor-related protein 4 ...  1099   0.0  
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...   816   0.0  
gi|93102379 low density lipoprotein-related protein 1B precursor...   764   0.0  
gi|126012573 low density lipoprotein-related protein 2 [Homo sap...   686   0.0  
gi|32698824 low density lipoprotein receptor-related protein 5-l...   329   2e-89
gi|209447022 low density lipoprotein receptor-related protein 5-...   329   2e-89
gi|65301167 very low density lipoprotein receptor isoform a [Hom...   244   4e-64
gi|61744471 low density lipoprotein receptor-related protein 8 i...   243   1e-63
gi|65301119 low density lipoprotein receptor-related protein 8 i...   243   1e-63
gi|65301164 very low density lipoprotein receptor isoform b [Hom...   242   2e-63
gi|61744467 low density lipoprotein receptor-related protein 8 i...   241   4e-63
gi|66082554 low density lipoprotein receptor-related protein 8 i...   241   4e-63
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...   239   2e-62
gi|4504975 low density lipoprotein receptor precursor [Homo sapi...   230   1e-59
gi|4507157 sortilin-related receptor containing LDLR class A rep...   204   4e-52
gi|115298674 nidogen 1 precursor [Homo sapiens]                       189   1e-47
gi|144953895 nidogen 2 precursor [Homo sapiens]                       176   1e-43
gi|28557796 low density lipoprotein receptor class A domain cont...   110   8e-24
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            109   2e-23
gi|29244926 corin [Homo sapiens]                                      102   4e-21
gi|11415040 matriptase [Homo sapiens]                                 101   5e-21
gi|134031945 SCO-spondin [Homo sapiens]                               100   9e-21
gi|208973262 low density lipoprotein-related protein 12 isoform ...    91   7e-18
gi|7305525 low density lipoprotein-related protein 12 isoform a ...    91   7e-18
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho...    87   1e-16
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho...    87   1e-16
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho...    87   1e-16
gi|167555125 low density lipoprotein receptor-related protein 3 ...    87   2e-16

>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
            sapiens]
          Length = 1613

 Score = 3350 bits (8685), Expect = 0.0
 Identities = 1613/1613 (100%), Positives = 1613/1613 (100%)

Query: 1    MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF 60
            MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
Sbjct: 1    MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF 60

Query: 61   SHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE 120
            SHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
Sbjct: 61   SHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE 120

Query: 121  VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE 180
            VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
Sbjct: 121  VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE 180

Query: 181  IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWT 240
            IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWT
Sbjct: 181  IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWT 240

Query: 241  DWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS 300
            DWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS
Sbjct: 241  DWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS 300

Query: 301  PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR 360
            PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
Sbjct: 301  PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR 360

Query: 361  HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT 420
            HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
Sbjct: 361  HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT 420

Query: 421  DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD 480
            DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD
Sbjct: 421  DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD 480

Query: 481  RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL 540
            RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL
Sbjct: 481  RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL 540

Query: 541  LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCS 600
            LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCS
Sbjct: 541  LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCS 600

Query: 601  HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG 660
            HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
Sbjct: 601  HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG 660

Query: 661  VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY 720
            VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY
Sbjct: 661  VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY 720

Query: 721  WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG 780
            WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
Sbjct: 721  WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG 780

Query: 781  SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ 840
            SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ
Sbjct: 781  SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ 840

Query: 841  YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHC 900
            YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHC
Sbjct: 841  YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHC 900

Query: 901  SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP 960
            SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP
Sbjct: 901  SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP 960

Query: 961  IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS 1020
            IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS
Sbjct: 961  IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS 1020

Query: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
            IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS
Sbjct: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080

Query: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1140
            PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE
Sbjct: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1140

Query: 1141 DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
            DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ
Sbjct: 1141 DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200

Query: 1201 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE 1260
            EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE
Sbjct: 1201 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE 1260

Query: 1261 IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK 1320
            IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK 1320

Query: 1321 NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGV 1380
            NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGV
Sbjct: 1321 NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGV 1380

Query: 1381 IVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS 1440
            IVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS
Sbjct: 1381 IVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS 1440

Query: 1441 RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM 1500
            RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM
Sbjct: 1441 RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM 1500

Query: 1501 EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL 1560
            EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL
Sbjct: 1501 EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL 1560

Query: 1561 NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613
            NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
Sbjct: 1561 NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613


>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
            sapiens]
          Length = 1615

 Score = 2366 bits (6131), Expect = 0.0
 Identities = 1130/1615 (69%), Positives = 1337/1615 (82%), Gaps = 20/1615 (1%)

Query: 4    VLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHG 63
            +L  L  C       A+PLLL+ANRRD+RLVDA   K  +TIVV GLEDAAAVDF FS G
Sbjct: 16   LLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKG 75

Query: 64   LIYWSDVSEEAIKRTEFNKT-ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122
             +YW+DVSEEAIK+T  N+T  +VQNVV+SGL+SPDGLACDW+G+KLYWTDSETNRIEV+
Sbjct: 76   AVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVA 135

Query: 123  NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182
            NL+G+ RKVLFWQ+LDQPRAIALDP+ G+MYWTDWGE P+IERAGMDGS+R II++S+IY
Sbjct: 136  NLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIY 195

Query: 183  WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
            WPNGLT+D EEQKLYWADAKL+FIH++NLDG+ RQ VV+GSL HPFALTL  D LYWTDW
Sbjct: 196  WPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDW 255

Query: 243  STHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPV 302
             T SI ACNK TG   +EI S ++SPMDI   SQ+RQP     C  DNGGCSHLCL+SP 
Sbjct: 256  QTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPS 315

Query: 303  KPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
            +PFY CACPTGV+L +NG+TCK GA E+LLLARRTDLRRISLDTPDFTDIVLQ++DIRHA
Sbjct: 316  EPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHA 375

Query: 363  IAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDT 422
            IAIDYDP+EGY+YWTDDEVRAIRR+++DGSG+Q +V  +I  PDGIAVDWVARNLYWTDT
Sbjct: 376  IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435

Query: 423  GTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRV 482
            GTDRIEVTRLNGT RKIL+SEDL+EPRAI L P++G MYWTDWGE PKIE A LDG +R 
Sbjct: 436  GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERR 495

Query: 483  VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLG 542
            VLVN SLGWPNGLALD  EGK+YWGDAKTDKIEV+N DGT RR L+EDK+PHIFGFTLLG
Sbjct: 496  VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLG 555

Query: 543  DYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHL 602
            D++YWTDWQRRSIERVHK  A R+VIIDQLPDLMGLKA NV +V+G+NPCA+ NGGCSHL
Sbjct: 556  DFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHL 615

Query: 603  CLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVK 662
            C + P   RC CPIG EL+SDMKTCIVPEAFL+F+ RA I RISLETNNN+VAIPLTGVK
Sbjct: 616  CFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVK 675

Query: 663  EASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
            EASALDFDV++N IYWTD+SLKTISRAFMNGS++EHVVEFGLDYPEGMAVDW+GKNLYWA
Sbjct: 676  EASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWA 735

Query: 723  DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSE 782
            DTGTNRIEV++LDGQ RQVLVW+DLD+PR+LALDP +G++YWTEWGGKP+I RA MDG+ 
Sbjct: 736  DTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTN 795

Query: 783  RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQ 842
              TLV  VGRAN LTIDYA +RLYWTDLDTN+IESSNMLG  R VIADDLPHPFGLTQY 
Sbjct: 796  CMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYS 855

Query: 843  DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSH 902
            DYIYWTDW+  SIERA+KTSG+NRT+IQGHLD+VMDILVFHSSRQ G N+C  +NG C  
Sbjct: 856  DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQ 915

Query: 903  LCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIH 962
            LCLA+P GG  CGC +HY+L+  +R CS PTTFLLFSQKSAI+RM+ D+Q SPD+ILP+H
Sbjct: 916  LCLAIP-GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLH 974

Query: 963  SLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSID 1022
             LRNV+AIDYDPLDK +YW+D RQN I++A++DG+Q F V+ S    QN + QP+DLSID
Sbjct: 975  GLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPF-VLTSLSQGQNPDRQPHDLSID 1032

Query: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082
            IYSR ++WTCEATN INV RL G ++GVVL+G++D+PRA+VVN E+GY+YFTN+Q+R+ K
Sbjct: 1033 IYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAK 1092

Query: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142
            IERAALDGTEREVLF +GL +P+AL +D+ LGKLFW D+DL+RIES DLSGANR+ LED+
Sbjct: 1093 IERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDA 1152

Query: 1143 NILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEY 1202
            NI+QP+GLT+    LYWID+QQQMIE+++ T  + RT++Q R+A L+ IHAV+E++L+E+
Sbjct: 1153 NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEF 1212

Query: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID 1262
              HPCA+DNGGCSHIC+ KGDGT RCSCP+HLVLLQ+ L+CGEPPTCSP QF C TGEID
Sbjct: 1213 SAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEID 1272

Query: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
            CIP AWRCDGF EC+D SDE  CPVCS +QF CA GQC+D  LRC+G+A+CQD+SDE +C
Sbjct: 1273 CIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1332

Query: 1323 EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEP---APQATNTVGSVIG 1379
            + +CL +QFRCA+GQC+   ++CD   DC D SDEL C  T+ P   +P  ++ +G VIG
Sbjct: 1333 DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG 1392

Query: 1380 VIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGM 1439
            +I+++FV G VYF+CQR++C R  G      ++Y V G   VPL ++    S  G   G+
Sbjct: 1393 IILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEY-VSGTPHVPLNFIAPGGSQHGPFTGI 1451

Query: 1440 SRGKSMISSLSIMGGSSGPP-YDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHY 1498
            + GKSM+SS+S+MGG  G P YDR HVTGASSSSSSSTK T +P ILNPPPSPAT+ S Y
Sbjct: 1452 ACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLY 1511

Query: 1499 TMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTS 1558
             M+  YSSN P+T R   YRPY  R  APPTTPCSTDVCDSDY+ SR       A  Y  
Sbjct: 1512 NMDMFYSSNIPATAR--PYRPYIIRGMAPPTTPCSTDVCDSDYSASR-----WKASKYYL 1564

Query: 1559 DLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613
            DLN DS+P PPPPTP SQYLSAE   +SCPPSP TERSY  HL+PPPPSPCTDSS
Sbjct: 1565 DLNSDSDPYPPPPTPHSQYLSAE---DSCPPSPATERSY-FHLFPPPPSPCTDSS 1615


>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
            sapiens]
          Length = 1905

 Score = 1099 bits (2843), Expect = 0.0
 Identities = 553/1226 (45%), Positives = 778/1226 (63%), Gaps = 26/1226 (2%)

Query: 14   CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
            C  L   P+LL+ANR D+R V     +   T+++  LE+A A+DF     L++WSDV+ +
Sbjct: 433  CKALGPEPVLLFANRIDIRQV--LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLD 490

Query: 74   AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF 133
             I R   N + +V+ VV +GL SP GLA DW+ +KLYWTDS T+RIEV+NLDG+ RKVL 
Sbjct: 491  RILRANLNGS-NVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLL 549

Query: 134  WQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEE 193
            WQ L++PRAIAL P  G +YWTDWG  P+IE + MDGS R II ++ ++WPNGLT+DY  
Sbjct: 550  WQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAG 609

Query: 194  QKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
            +++YW DAK + I ++NLDG++R+AV+   LPHPFA+T+FED LYWTDW T SI + NK+
Sbjct: 610  RRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 669

Query: 254  TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTG 313
            TG+    I + +  PMDIH    QRQP   N CG +NGGC+HLCL  P    Y CACPTG
Sbjct: 670  TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTG 727

Query: 314  VKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGY 373
             + + +   C     + LL ARR D+RRIS DT D +D V+ L D+R A+A+D+D  + +
Sbjct: 728  FRKI-SSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDH 786

Query: 374  IYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLN 433
            +YWTD     I R+  DG+G + VV   +  P G+A+DWV   LYWTD GTDRIEV   +
Sbjct: 787  VYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTD 846

Query: 434  GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPN 493
            G+MR +LI E+L+ PR IV++PM GYMYWTDWG  PKIERA +D S R V+++++L WPN
Sbjct: 847  GSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPN 906

Query: 494  GLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRR 553
            GLA+DY   ++YW DA    IE    DG+ R+VL+  ++PH FG TL G+ +YWTDWQ +
Sbjct: 907  GLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTK 966

Query: 554  SIERVHKRSA-EREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLY--RPQGL 610
            SI+   + +  +RE + + L +LM +   +  R   S PCA ENGGCSHLCL    P G 
Sbjct: 967  SIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026

Query: 611  RCACPIGFELISDMKTCIV-PEAFLLFSRRADIRRISLETNN-NNVAIPLT-GVKEASAL 667
             C CP G  L+SD KTC     +FL+F+RR DIR +SL+     +V +P+   +K   A+
Sbjct: 1027 SCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAI 1086

Query: 668  DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTN 727
              D  + ++YW+D +L  ISRA ++GS  E ++  GL   +G+AVD +G+ +YW DTGTN
Sbjct: 1087 GVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTN 1146

Query: 728  RIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV 787
            RIEV  LDG  R+VLVW++LDSPRA+ L    GFMYWT+WG   K++R+ MDGS+R  L+
Sbjct: 1147 RIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLI 1206

Query: 788  -PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIY 846
              N+G  NGLT+D A  +L W D  T  IE++++ G NR  +   + HP+GLT    YIY
Sbjct: 1207 NNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIY 1266

Query: 847  WTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLA 906
            WTDW  RSI RA+K +G N  +++ +L  +MD+     ++  G+N+C S NG CSHLCL 
Sbjct: 1267 WTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLP 1326

Query: 907  VPVGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
             P  GF C CP    L  D +TC  +P T+LLFS + +I R+ +D     D+ +P+  L 
Sbjct: 1327 RP-SGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELN 1385

Query: 966  NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS 1025
            NV ++DYD +D ++Y+ D   ++IR+A  +GS   TV+   + + +       L++D  +
Sbjct: 1386 NVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD------GLAVDWVA 1439

Query: 1026 RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIER 1085
            R +YWT    N I  +RLDG    V++    D PRA+ V P KGY+++T+    + KIER
Sbjct: 1440 RNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA-KIER 1498

Query: 1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNIL 1145
            A LDG+ER+VL  + L  P  L LD    +++W D+ L RIES+DL+G  R VL  S++ 
Sbjct: 1499 ANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVS 1557

Query: 1146 QPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQH 1205
             P  LT  + W+YW D Q + I+++D      +  V A +  L DI  V     ++   +
Sbjct: 1558 HPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSP--QRQTGTN 1615

Query: 1206 PCAQDNGGCSHICLVKGDGTTRCSCP 1231
             C  +NGGC+H+C  +      C+CP
Sbjct: 1616 ACGVNNGGCTHLCFARASDFV-CACP 1640



 Score =  743 bits (1919), Expect = 0.0
 Identities = 401/1011 (39%), Positives = 584/1011 (57%), Gaps = 65/1011 (6%)

Query: 286  CGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-------------------- 325
            C ++NGGC+  C M  V+   QC C TG +L E+G TC+D                    
Sbjct: 358  CNVNNGGCAQKCQM--VRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGA 415

Query: 326  ---------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIA 364
                                 G   +LL A R D+R++    P  ++  L L ++ +AIA
Sbjct: 416  FQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQV---LPHRSEYTLLLNNLENAIA 472

Query: 365  IDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGT 424
            +D+      ++W+D  +  I R+ ++GS  + VV+  +  P G+AVDWV   LYWTD+GT
Sbjct: 473  LDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532

Query: 425  DRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVL 484
             RIEV  L+G  RK+L+ ++LE+PRAI L PM G +YWTDWG  P+IE +++DGS R ++
Sbjct: 533  SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592

Query: 485  VNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY 544
             +T L WPNGL +DY   ++YW DAK   IE  N DG+ R+ ++   +PH F  T+  D 
Sbjct: 593  ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDS 652

Query: 545  VYWTDWQRRSIERVHKRSAE-REVIIDQLPDLMGLKATNVHR-VIGSNPCAEENGGCSHL 602
            +YWTDW  +SI   +K + + +E+I ++L   M +   +  R   G N C + NGGC+HL
Sbjct: 653  LYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHL 712

Query: 603  CLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNN-NNVAIPLTGV 661
            CL   Q   CACP GF  IS        + FLLF+RR DIRRIS +T + ++  IPL  V
Sbjct: 713  CLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADV 772

Query: 662  KEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721
            + A ALD+D  D+ +YWTD+S  TISRA  +G+  E VV+  L+ P G+A+DW+   LYW
Sbjct: 773  RSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYW 832

Query: 722  ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
             D GT+RIEV+  DG  R VL+W++LD PR + ++P  G+MYWT+WG  PKI+RA MD S
Sbjct: 833  TDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDAS 892

Query: 782  ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREV-IADDLPHPFGLT 839
             R  ++  N+   NGL IDY  +RLYW D     IE + + G  R+V I   LPHPFGLT
Sbjct: 893  GRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLT 952

Query: 840  QYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGH 899
             Y + IYWTDW  +SI+ A++ +G +R  +Q +L+ +MDI VFH  R      CA  NG 
Sbjct: 953  LYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGG 1012

Query: 900  CSHLCLAVP-VGGFVCGCPAHYSLNADNRTCS-APTTFLLFSQKSAINRMVIDEQQSPDI 957
            CSHLCL  P   GF C CP   +L +D +TCS    +FL+F+++  I  + +D     D+
Sbjct: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADV 1072

Query: 958  ILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQP 1016
            ++PI+ +++N  AI  DP + ++YW DS  + I +A  DGSQ   ++ + + + +     
Sbjct: 1073 VVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD----- 1127

Query: 1017 YDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNL 1076
              L++D   R +YWT   TN I V  LDG    V++    D PRA+V+  E G+MY+T+ 
Sbjct: 1128 -GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDW 1186

Query: 1077 QERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
             E + K+ER+ +DG++R VL  + L  P  L +D    +L WAD+   RIE++DL+GANR
Sbjct: 1187 GENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245

Query: 1137 IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKE 1196
              L  S +  P GLT+ ++++YW D Q + I + D         V++ +  L D+ AV  
Sbjct: 1246 HTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVD- 1303

Query: 1197 LNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP 1247
               Q    + C   NGGCSH+CL +  G + C+CP  + L  D  +C   P
Sbjct: 1304 -RAQPLGFNKCGSRNGGCSHLCLPRPSGFS-CACPTGIQLKGDGKTCDPSP 1352



 Score =  485 bits (1248), Expect = e-136
 Identities = 272/682 (39%), Positives = 395/682 (57%), Gaps = 29/682 (4%)

Query: 590  NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IVPEAFLLFSRRADIRRISL 647
            N CAEE G CS  C       +C C  G+EL  D ++C  + PE  LLF+ R DIR++  
Sbjct: 397  NECAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL- 454

Query: 648  ETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
              + +   + L  ++ A ALDF      ++W+D++L  I RA +NGS +E VV  GL+ P
Sbjct: 455  -PHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESP 513

Query: 708  EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEW 767
             G+AVDW+   LYW D+GT+RIEV+ LDG HR+VL+W++L+ PRA+AL P EG +YWT+W
Sbjct: 514  GGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW 573

Query: 768  GGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE 826
            G  P+I+ ++MDGS R  +   ++   NGLTIDYA RR+YW D   ++IE +N+ G +R+
Sbjct: 574  GNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRK 633

Query: 827  -VIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSS 885
             VI+  LPHPF +T ++D +YWTDW  +SI  ANK +G+N+ II+  L + MDI   H  
Sbjct: 634  AVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQ 693

Query: 886  RQ-SGWNECASSNGHCSHLCLAVPVG-GFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSA 943
            RQ +G N C  +NG C+HLCL  P G  + C CP  +   + +    +   FLLF+++  
Sbjct: 694  RQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMD 751

Query: 944  INRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVV 1003
            I R+  D +   D ++P+  +R+  A+D+D  D  +YW D   + I +A+ DG+    VV
Sbjct: 752  IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVV 811

Query: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVV 1063
             +S+ S      P  L+ID  +  +YWT   T+ I V   DG    V++    DRPR +V
Sbjct: 812  DTSLES------PAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIV 865

Query: 1064 VNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL 1123
            V P  GYMY+T+    SPKIERA +D + R+V+  S L+ P  LA+D    +L+WAD+ +
Sbjct: 866  VEPMGGYMYWTD-WGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGM 924

Query: 1124 RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQA 1183
            + IE + L G+ R VL  S +  P GLT++   +YW D Q + I+  D      R  +Q 
Sbjct: 925  KTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQE 984

Query: 1184 RIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGT-TRCSCPMHLVLLQDELS 1242
             +  L DIH       +     PCA +NGGCSH+CL   + +   C+CP  + LL D   
Sbjct: 985  NLENLMDIHVFH--RRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSD--- 1039

Query: 1243 CGEPPTCSP--QQFTCFTGEID 1262
                 TCSP    F  F   ID
Sbjct: 1040 ---GKTCSPGMNSFLIFARRID 1058



 Score =  142 bits (357), Expect = 3e-33
 Identities = 103/387 (26%), Positives = 174/387 (44%), Gaps = 55/387 (14%)

Query: 887  QSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS---------------- 930
            ++G   C  +NG C+  C  V  G   C C   Y L  D  TC                 
Sbjct: 352  RTGEENCNVNNGGCAQKCQMVR-GAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410

Query: 931  --------------------------APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSL 964
                                       P   LLF+ +  I R V+  +    ++L  ++L
Sbjct: 411  NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDI-RQVLPHRSEYTLLL--NNL 467

Query: 965  RNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIY 1024
             N  A+D+    + ++W D   + I +A  +GS      V  V S  LE  P  L++D  
Sbjct: 468  ENAIALDFHHRRELVFWSDVTLDRILRANLNGSN-----VEEVVSTGLE-SPGGLAVDWV 521

Query: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
               +YWT   T+ I V  LDG    V+L    ++PRA+ ++P +G +Y+T+    +P+IE
Sbjct: 522  HDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD-WGNTPRIE 580

Query: 1085 RAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNI 1144
             +++DG+ R ++  + L  P  L +D    +++W D+    IE ++L G++R  +    +
Sbjct: 581  ASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGL 640

Query: 1145 LQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ 1204
              P  +TVFE+ LYW D   + I   +    + +  ++ ++    DIH +     Q   +
Sbjct: 641  PHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP-QRQPAGK 699

Query: 1205 HPCAQDNGGCSHICLVKGDGTTRCSCP 1231
            + C  +NGGC+H+CL  G   T C+CP
Sbjct: 700  NRCGDNNGGCTHLCLPSGQNYT-CACP 725



 Score =  121 bits (304), Expect = 5e-27
 Identities = 57/125 (45%), Positives = 75/125 (60%), Gaps = 8/125 (6%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
            DE  C     C   +F C +G   CI   WRCDG  +C+D SDE NC   +C+  QF+C 
Sbjct: 221  DESDCSSHQPCRSGEFMCDSGL--CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCH 278

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL----CLIDQFRCANGQCIGKHKKCDHNVDCS 1352
            SG+C+  + RC+G+ +C D SDE+NCE      C +DQF C NG+CIG+ K C+   DC 
Sbjct: 279  SGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCG 338

Query: 1353 DKSDE 1357
            D SDE
Sbjct: 339  DNSDE 343



 Score =  121 bits (303), Expect = 6e-27
 Identities = 68/167 (40%), Positives = 87/167 (52%), Gaps = 16/167 (9%)

Query: 1213 GCSHI-CLVKGDGTTRCSCPMHLVLLQDELSCGEP--------PTCSPQQFTCFTGEIDC 1263
            G SH  C V   G   C+C         +  CG+         PTCSP  F C  G+  C
Sbjct: 28   GRSHFTCAVSALG--ECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK--C 83

Query: 1264 IPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCIDGALRCNGDANCQDKSDEKN 1321
            I  +W CDG  +CED SDE +CP   C E +F C +G CI     C+GD +C D SDE+ 
Sbjct: 84   IRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQC 143

Query: 1322 CEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAP 1368
                C   +FRC++G CI +H  CD + DC D SDE +C P+  PAP
Sbjct: 144  DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC-PSAVPAP 189



 Score =  114 bits (285), Expect = 8e-25
 Identities = 58/148 (39%), Positives = 80/148 (54%), Gaps = 16/148 (10%)

Query: 1223 DGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
            DG+   +CP          S    P C+ ++F C  G   CI   + CDG  +C D SDE
Sbjct: 175  DGSDEENCP----------SAVPAPPCNLEEFQCAYGR--CILDIYHCDGDDDCGDWSDE 222

Query: 1283 LNCPV---CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQC 1338
             +C     C   +F C SG CI+   RC+GDA+C D+SDE+NC   +C  +QFRC +G+C
Sbjct: 223  SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282

Query: 1339 IGKHKKCDHNVDCSDKSDELDCYPTEEP 1366
            +    +CD   DC+D SDE +C  T  P
Sbjct: 283  VRLSWRCDGEDDCADNSDEENCENTGSP 310



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 53/168 (31%), Positives = 73/168 (43%), Gaps = 39/168 (23%)

Query: 1206 PCAQDNGGC-SHICLVKG---DGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEI 1261
            PC      C S +C+  G   DG   C          DE +C     C+ +QF C +G  
Sbjct: 230  PCRSGEFMCDSGLCINAGWRCDGDADCDDQ------SDERNC-TTSMCTAEQFRCHSGR- 281

Query: 1262 DCIPVAWRCDGFTECEDHSDELNC-----PVCSESQFQCASGQCIDGALRCNG------- 1309
             C+ ++WRCDG  +C D+SDE NC     P C+  QF C +G+CI     CNG       
Sbjct: 282  -CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDN 340

Query: 1310 -----DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
                   NC+ ++ E+NC V          NG C  K +     V C+
Sbjct: 341  SDESPQQNCRPRTGEENCNV---------NNGGCAQKCQMVRGAVQCT 379


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score =  816 bits (2107), Expect = 0.0
 Identities = 481/1398 (34%), Positives = 767/1398 (54%), Gaps = 77/1398 (5%)

Query: 21   PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
            P ++++NR ++R +D   G  + +++V GL +  A+DF  S   +YW+DV E+ I R + 
Sbjct: 1269 PFIIFSNRHEIRRIDLHKG--DYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKL 1326

Query: 81   ---NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQEL 137
                   S + V+  GL +P+GLA DW+   +YW +S  ++IEV+ LDG+LR  L   ++
Sbjct: 1327 LDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI 1386

Query: 138  DQPRAIALDPSSGFMYWTDW-GEVPKIERAGMDGSSRFII--INSEIYWPNGLTLDYEEQ 194
            + PRAIALDP  G ++WTDW   +P+IE A M G+ R  +        WPNGLT+DY E+
Sbjct: 1387 EHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEK 1446

Query: 195  KLYWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNK 252
            ++ W DA+ + I+ +  DG+    V++G   L HPFA+TL+   +YWTDW T+++   NK
Sbjct: 1447 RILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANK 1506

Query: 253  YTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID--NGGCSHLCLMSPVKPFYQCAC 310
            +TG  +  +      P D+  +   RQP A NPC  +   G CSHLCL++       CAC
Sbjct: 1507 WTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLIN-YNRTVSCAC 1565

Query: 311  PTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIV-LQLEDIRHAIAIDYDP 369
            P  +KL ++  TC +   + LL AR+ ++R + LD P +  I+   + DI +   +DYD 
Sbjct: 1566 PHLMKLHKDNTTCYE-FKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDA 1624

Query: 370  VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT--DTGTDRI 427
             E  +YW+D   +AI+R+FI+G+G + VV+A + +  G+AVDWV+RNL+WT  DT   +I
Sbjct: 1625 REQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQI 1684

Query: 428  EVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNT 487
             V RL+G+ +  ++ + LE+P  +V+ P+ G +YWTD      I  A +DGS+R +L + 
Sbjct: 1685 NVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDG---DNISMANMDGSNRTLLFSG 1740

Query: 488  SLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL--VEDKIPHIFGFTLLGDYV 545
              G P GLA+D+ E K+YW  +    I   N DG+G  V+  +  ++       ++GD +
Sbjct: 1741 QKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKL 1799

Query: 546  YWTDWQRRSIERVHKRSAEREVIIDQLPDL-MGLKATNVHRVI---GSNPCAEENGGCSH 601
            +W D     +    K      V++     L M +K  +    +   G+NPC+  NG CS 
Sbjct: 1800 WWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQ 1859

Query: 602  LCLYRPQGLR-CACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVA-IPLT 659
            LCL   +  R C C  G+ L S  + C    +FLL+S    IR I L+ N+ + A +P++
Sbjct: 1860 LCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVS 1919

Query: 660  GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNL 719
            G   A  +DF   ++ IYW D+ L TISRA  + +  E VV  G+   EG+AVDW+  N+
Sbjct: 1920 GTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNI 1979

Query: 720  YWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD 779
            YW D G + IEV++L+G  R V++ + LD PRA+ + P +G+++WTEWG  P+I+R+ +D
Sbjct: 1980 YWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLD 2039

Query: 780  GSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNM-LGLNREVI-ADDLPHPF 836
            G+ER  LV  ++   NG+++DY   +LYW D  T+ IE  ++  G NREV+ + +    F
Sbjct: 2040 GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMF 2099

Query: 837  GLTQYQDYIYWTD--WSRRSIERANKTSGQNRTIIQGHLD-YVMDILVFHSSRQSGWNEC 893
             ++ ++D+IYW+D   +  SI+R +K +  +   ++  +   + DI VF+  RQ G N C
Sbjct: 2100 SVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVC 2159

Query: 894  ASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQ 953
            A +NG C  LCL    G   C C AH  L  D  +C     +LL+S+++ +  + + +++
Sbjct: 2160 AVANGGCQQLCLYRGRGQRACAC-AHGMLAEDGASCREYAGYLLYSERTILKSIHLSDER 2218

Query: 954  SPDIIL-----PIHSLRNVRAIDYD-------PLDKQLYWIDSRQNMIRKAQEDGSQGFT 1001
            + +  +     P H ++NV A+ +D           ++++ D     I++  +DGS+  T
Sbjct: 2219 NLNAPVQPFEDPEH-MKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRIT 2277

Query: 1002 VVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG------VVLKGE 1055
            +V +    + L    Y    D     +YWT   T+ I    +D    G      V+    
Sbjct: 2278 IVENVGSVEGL---AYHRGWDT----LYWTSYTTSTITRHTVDQTRPGAFERETVITMSG 2330

Query: 1056 QDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGK 1115
             D PRA V++  +  M++TN  E+ P I RAAL G     L    +  P  LA+D R  K
Sbjct: 2331 DDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEK 2390

Query: 1116 LFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGR 1175
            L+++D+ L +IE  +  G++R V+  S  + P GL V+   ++W D  ++ +++ +    
Sbjct: 2391 LYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVG 2450

Query: 1176 EGRTKVQARIAQ--LSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMH 1233
                 ++  I Q  +  I    + N  E    PC  +NGGC  +CL+   G   CSC   
Sbjct: 2451 SNMKLLRVDIPQQPMGIIAVANDTNSCEL--SPCRINNGGCQDLCLLTHQGHVNCSCRGG 2508

Query: 1234 LVLLQDELSC-GEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCPV 1287
             + LQD+L+C     +C  Q +F C  GE  CI  +  CDG   C+D SDE     N   
Sbjct: 2509 RI-LQDDLTCRAVNSSCRAQDEFECANGE--CINFSLTCDGVPHCKDKSDEKPSYCNSRR 2565

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C ++  QC++G+C+   L CNG  +C D SDE  C +  C + +FRC +G CIG   +C+
Sbjct: 2566 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCN 2625

Query: 1347 HNVDCSDKSDELDCYPTE 1364
              VDC D SDE++C  T+
Sbjct: 2626 QFVDCEDASDEMNCSATD 2643



 Score =  537 bits (1384), Expect = e-152
 Identities = 338/1030 (32%), Positives = 524/1030 (50%), Gaps = 88/1030 (8%)

Query: 286  CGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK--------------------- 324
            C ++NGGCSH C ++P +    C+CP G++L  +  TC+                     
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIV-CSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243

Query: 325  ---------------------DGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
                                 D     ++ + R ++RRI L   D++ +V     +R+ I
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLV---PGLRNTI 1300

Query: 364  AIDYDPVEGYIYWTDD-EVRAIRRSFID-GSGSQFVVTAQ--IAHPDGIAVDWVARNLYW 419
            A+D+   +  +YWTD  E +  R   +D G+ + F V  Q  +A P+G+AVDW+A N+YW
Sbjct: 1301 ALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYW 1360

Query: 420  TDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW-GEIPKIERAALDG 478
             ++  D+IEV +L+GT+R  L++ D+E PRAI LDP  G ++WTDW   +P+IE A++ G
Sbjct: 1361 VESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSG 1420

Query: 479  SDR--VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV--EDKIPH 534
            + R  V     S GWPNGL +DY E +I W DA++D I     DG+G   ++   + + H
Sbjct: 1421 AGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSH 1480

Query: 535  IFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQL-PDLMGLKATNVHR-VIGSNPC 592
             F  TL G  VYWTDW+  ++ + +K +     ++ +       L+  +  R  +  NPC
Sbjct: 1481 PFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPC 1540

Query: 593  AEENGG---CSHLCLYR-PQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLE 648
             E NGG   CSHLCL    + + CACP   +L  D  TC   + FLL++R+ +IR + L+
Sbjct: 1541 -EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLD 1599

Query: 649  TNNNNVAIPLT--GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDY 706
                N  I  T   +   + LD+D  + R+YW+D+  + I RAF+NG+ +E VV   L  
Sbjct: 1600 APYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPN 1659

Query: 707  PEGMAVDWLGKNLYWA--DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYW 764
              G+AVDW+ +NL+W   DT   +I V++LDG  +  +V + L+ P  L + P  G +YW
Sbjct: 1660 AHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYW 1718

Query: 765  TEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN 824
            T+      I  A MDGS RT L        GL ID+ + +LYW     + I   N+ G  
Sbjct: 1719 TD---GDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSG 1775

Query: 825  REVI---ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILV 881
             EVI      L     L    D ++W D     +   +K  G    +++     VM + V
Sbjct: 1776 LEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKV 1835

Query: 882  FHSSRQ---SGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLF 938
            +  S Q    G N C+ +NG CS LCL        C C A YSL +  + C    +FLL+
Sbjct: 1836 YDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLY 1895

Query: 939  SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
            S    I  + +D     D ++P+        ID+   +  +YW+D   + I +A+ D + 
Sbjct: 1896 SVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW 1955

Query: 999  GFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDR 1058
               VV + +       +   +++D  +  IYWT +  +VI V RL+G    VV+    D+
Sbjct: 1956 REDVVTNGIG------RVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDK 2009

Query: 1059 PRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFW 1118
            PRA+ V+PEKGY+++T   +  P+IER+ LDGTER VL    +S P  +++D + GKL+W
Sbjct: 2010 PRAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYW 2068

Query: 1119 ADSDLRRIESSDL-SGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREG 1177
             D+   +IE  DL +G NR V+  SN +    ++VFE+++YW D+       I    ++ 
Sbjct: 2069 CDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHAN-GSIKRGSKDN 2127

Query: 1178 RT-KVQARIAQLSDIHAVKELNLQEYR-QHPCAQDNGGCSHICLVKGDGTTRCSCPMHLV 1235
             T  V  R      +  +K  N    +  + CA  NGGC  +CL +G G   C+C  H +
Sbjct: 2128 ATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC-AHGM 2186

Query: 1236 LLQDELSCGE 1245
            L +D  SC E
Sbjct: 2187 LAEDGASCRE 2196



 Score =  343 bits (881), Expect = 6e-94
 Identities = 214/655 (32%), Positives = 353/655 (53%), Gaps = 45/655 (6%)

Query: 21  PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
           P+LL AN +++ L    +G + +TI         A+DF +++  + W  V + A + T+ 
Sbjct: 199 PVLLIANSQNI-LATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQ-TQL 256

Query: 81  NKT----------ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRK 130
                        E   N+ +S L   + +A DWL    Y+ D   +RI V N +G    
Sbjct: 257 KCARMPGLKGFVDEHTINISLS-LHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCV 315

Query: 131 VLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLD 190
            L   EL  P+ IALDP+ G +++TD+G++PK+ER  MDG +R  +++S+I +P+G+TLD
Sbjct: 316 TLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLD 375

Query: 191 YEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL-PHPFALTLFEDILYWTD------WS 243
              + +YWADA L++I   + +G  RQ +++G L  H + LT+FE+ LY T+        
Sbjct: 376 LVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQ 435

Query: 244 THSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNA-TNPCGIDN----GGCSHLCL 298
             S++  N++      ++ + +     +H + Q+RQP   ++ C  D     GGCS +CL
Sbjct: 436 KTSVIRVNRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494

Query: 299 MSPVKPFYQCACPTGVKLLENGKTCKDGATELLLL---ARRTDLRRISLDTPDFTDIVLQ 355
           ++       C C +G  L  +GK+CK    EL L+    R   +R + +      + ++ 
Sbjct: 495 LANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIP 554

Query: 356 LEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVAR 415
           +E++ +  A+D+    G+IY+ D     I R  IDG+  + ++   I + +G+AVDW+  
Sbjct: 555 IENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614

Query: 416 NLYWTDTGTDR-IEVTRLN--GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPK-- 470
           NLYWTD G  + I V RL      RK LI   +  PRAIV+DP+ G+MYWTDW E PK  
Sbjct: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDS 674

Query: 471 ----IERAALDGSDRVVLVNT-SLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRR 525
               +ERA +DGS R + V + ++ WPNGL+LD   G++YW DA  D+IE +  +GT R+
Sbjct: 675 RRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRK 734

Query: 526 VLVE-DKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQL----PDLMGLKA 580
           ++ E  ++ H FG    G+Y++WT+++  S+ R+ +        +  L    P +  ++ 
Sbjct: 735 IVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRM 794

Query: 581 TNV-HRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFL 634
            +   + +G+N C   NGGCS LCL  P   +CAC     L +D  TC+   +++
Sbjct: 795 YDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849



 Score =  328 bits (841), Expect = 3e-89
 Identities = 248/884 (28%), Positives = 412/884 (46%), Gaps = 111/884 (12%)

Query: 598  GCSHLCLYRPQGLRCACPIGFELISDMKTCI-------------------------VPEA 632
            GC H C+    G  C C   F+L +D KTC                            E 
Sbjct: 119  GCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEG 178

Query: 633  FLL---------FSRRADIRRISLETNNNNV-----------AIPLTGVKEASALDFDVT 672
            +LL          +   D   + L  N+ N+            I  T  ++ +A+DF   
Sbjct: 179  YLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYA 238

Query: 673  DNRIYWTDI-------SLKTISRAFMNGSALEHVVEFGLD--YPEGMAVDWLGKNLYWAD 723
            +  + W  +        LK      + G   EH +   L   + E MA+DWL  N Y+ D
Sbjct: 239  NETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVD 298

Query: 724  TGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSER 783
               +RI V   +G     L+  +L +P+ +ALDPA G +++T++G  PK++R  MDG  R
Sbjct: 299  DIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNR 358

Query: 784  TTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD--LPHPFGLTQ 840
            T LV + +   +G+T+D   R +YW D   + IE  +  G  R+ I     + H +GLT 
Sbjct: 359  TKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTV 418

Query: 841  YQDYIYWTD------WSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECA 894
            +++Y+Y T+        + S+ R N+ +     ++   +D    + ++H  RQ      A
Sbjct: 419  FENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHA 477

Query: 895  SSN------GHCSHLC-LAVPVGGFVCGCPAHYSLNADNRTCSAP--TTFLLF--SQKSA 943
              N      G CS +C LA       C C + +SL +D ++C  P    FL++   +   
Sbjct: 478  CENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGI 537

Query: 944  INRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVV 1003
            I  M +  +   + ++PI +L N RA+D+      +Y+ D+   +I + + DG++  T++
Sbjct: 538  IRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETIL 597

Query: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA-TNVINVTRLD--GRSVGVVLKGEQDRPR 1060
               +   N+E     +++D     +YWT +     I+V RL+   ++   +++G+   PR
Sbjct: 598  KDGI--HNVE----GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPR 651

Query: 1061 AVVVNPEKGYMYFTNLQE-----RSPKIERAALDGTEREVLFFS-GLSKPIALALDSRLG 1114
            A+VV+P  G+MY+T+ +E     R  ++ERA +DG+ R++   S  +  P  L+LD   G
Sbjct: 652  AIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAG 711

Query: 1115 KLFWADSDLRRIESSDLSGANR-IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMT 1173
            +L+W D+   RIE+  L+G +R IV E   +    GL    N+L+W + +   + +++  
Sbjct: 712  RLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERG 771

Query: 1174 GREGRTKVQARIAQLSDIHAVKELNLQEYR--QHPCAQDNGGCSHICLVKGDGTTRCSCP 1231
                   V    ++   I  ++  + Q+ +   + C  +NGGCS +CL    G+ +C+C 
Sbjct: 772  VGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLAT-PGSRQCACA 830

Query: 1232 MHLVLLQDELSC------GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--- 1282
               VL  D ++C        PP C P +F C      CI   W+CDG  +C D+SDE   
Sbjct: 831  EDQVLDADGVTCLANPSYVPPPQCQPGEFACANSR--CIQERWKCDGDNDCLDNSDEAPA 888

Query: 1283 -LNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV---LCLIDQFRCANGQC 1338
              +   C   +F+C + +CI     C+GD +C +  DE N       C  +QF CA+G+C
Sbjct: 889  LCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRC 948

Query: 1339 IGKHKKCDHNVDCSDKSDE-LDC-YPTEEPAPQATNTVGSVIGV 1380
            I     CD + DC D+SDE   C YPT  P  Q T   G  I +
Sbjct: 949  IPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCINI 992



 Score =  324 bits (831), Expect = 4e-88
 Identities = 242/865 (27%), Positives = 404/865 (46%), Gaps = 112/865 (12%)

Query: 597  GGCSHLCLYRPQGLRCACPIGFELISDMKTC------IVPEAFLLFSRRADIRRISLETN 650
            G CS LC        C C  G+ L  D ++C      +     LL +   +I    L   
Sbjct: 158  GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217

Query: 651  NNNVAIPLTGVKEASALDFDVTDNRIYWTDIS-------LKTISRAFMNGSALEHVVEFG 703
              +   P T  ++ +A+DF   +  + W  +        LK      + G   EH +   
Sbjct: 218  QVSTITP-TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINIS 276

Query: 704  LD--YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGF 761
            L   + E MA+DWL  N Y+ D   +RI V   +G     L+  +L +P+ +ALDPA G 
Sbjct: 277  LSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGK 336

Query: 762  MYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNM 820
            +++T++G  PK++R  MDG  RT LV + +   +G+T+D   R +YW D   + IE  + 
Sbjct: 337  VFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDY 396

Query: 821  LGLNREVIADDL--PHPFGLTQYQDYIYWTD------WSRRSIERANKTSGQNRTIIQGH 872
             G  R+ I   +   H +GLT +++Y+Y T+        + S+ R N+ +     ++   
Sbjct: 397  EGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-R 455

Query: 873  LDYVMDILVFHSSRQSGWNECASSN------GHCSHLCL-AVPVGGFVCGCPAHYSLNAD 925
            +D    + ++H  RQ      A  N      G CS +CL A       C C + +SL +D
Sbjct: 456  VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515

Query: 926  NRTCSAPT--TFLLFSQ--KSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYW 981
             ++C  P    FL++ +     I  M +  +   + ++PI +L N RA+D+      +Y+
Sbjct: 516  GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYF 575

Query: 982  IDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN-VINV 1040
             D+   +I + + DG++  T++   +   N+E     +++D     +YWT +     I+V
Sbjct: 576  ADTTSYLIGRQKIDGTERETILKDGI--HNVE----GVAVDWMGDNLYWTDDGPKKTISV 629

Query: 1041 TRLD--GRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQE-----RSPKIERAALDGTER 1093
             RL+   ++   +++G+   PRA+VV+P  G+MY+T+ +E     R  ++ERA +DG+ R
Sbjct: 630  ARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHR 689

Query: 1094 EVLFFSG-LSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQPVGLT 1151
            ++   S  +  P  L+LD   G+L+W D+   RIE+  L+G +R IV E   +    GL 
Sbjct: 690  DIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLC 749

Query: 1152 VFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR--QHPCAQ 1209
               N+L+W + +   + +++         V    ++   I  ++  + Q+ +   + C  
Sbjct: 750  HHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRV 809

Query: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC------GEPPTCSPQQFTCFTGEIDC 1263
            +NGGCS +CL    G+ +C+C    VL  D ++C        PP C P +F C      C
Sbjct: 810  NNGGCSSLCLAT-PGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSR--C 866

Query: 1264 IPVAWRCDGFTECEDHSDEL-------NCP------------------------------ 1286
            I   W+CDG  +C D+SDE         CP                              
Sbjct: 867  IQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 926

Query: 1287 --------VCSESQFQCASGQCIDGALRCNGDANCQDKSDEK-NCEV-LCL-IDQFRCAN 1335
                     C  +QF CASG+CI  +  C+ D +C D+SDE  +C    C  + QF C N
Sbjct: 927  SNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNN 986

Query: 1336 GQCIGKHKKCDHNVDCSDKSDELDC 1360
            G+CI  + +CD++ DC D SDE  C
Sbjct: 987  GRCININWRCDNDNDCGDNSDEAGC 1011



 Score =  315 bits (808), Expect = 2e-85
 Identities = 211/697 (30%), Positives = 352/697 (50%), Gaps = 56/697 (8%)

Query: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-----GATELLLLARRTDLRRISLD 345
           G CS LC  +     + C C  G  L  + ++CK          +LL+A   ++    L 
Sbjct: 158 GTCSQLCTNTDGS--FICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215

Query: 346 TPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWT-------DDEVRAIRRSFIDGSGSQFVV 398
               + I       R   A+D+      + W          +++  R   + G   +  +
Sbjct: 216 GAQVSTITPT--STRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTI 273

Query: 399 TAQIA--HPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPM 456
              ++  H + +A+DW+  N Y+ D   DRI V   NG     L+  +L  P+ I LDP 
Sbjct: 274 NISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333

Query: 457 VGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEV 516
           +G +++TD+G+IPK+ER  +DG +R  LV++ + +P+G+ LD     +YW DA  D IEV
Sbjct: 334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEV 393

Query: 517 MNTDGTGRRVLVED-KIPHIFGFTLLGDYVYWTD------WQRRSIERVHKRSAEREVII 569
           ++ +G GR+ +++   I H++G T+  +Y+Y T+       Q+ S+ RV++ ++    ++
Sbjct: 394 VDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVV 453

Query: 570 DQLPDLMGLKATNVHRV--IGSNPCAEEN----GGCSHLCLY--RPQGLRCACPIGFELI 621
            ++     L   +  R   + S+ C  +     GGCS +CL     +   C C  GF L 
Sbjct: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLG 513

Query: 622 SDMKTCIVP--EAFLLF--SRRADIRRISLETN-NNNVAIPLTGVKEASALDFDVTDNRI 676
           SD K+C  P  E FL++   R   IR + +     +   IP+  +    ALDF      I
Sbjct: 514 SDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFI 573

Query: 677 YWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLD 735
           Y+ D +   I R  ++G+  E +++ G+   EG+AVDW+G NLYW D G  + I V++L+
Sbjct: 574 YFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633

Query: 736 --GQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPK------IDRAAMDGSERTTLV 787
              Q R+ L+   +  PRA+ +DP  G+MYWT+W   PK      ++RA MDGS R   V
Sbjct: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693

Query: 788 PN--VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIAD--DLPHPFGLTQYQD 843
            +  V   NGL++D    RLYW D   + IE+  + G +R+++ +  +L H FGL  + +
Sbjct: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753

Query: 844 YIYWTDWSRRSIERANKTSG---QNRTIIQGHLDYVMDILVFHSSRQS-GWNECASSNGH 899
           Y++WT++   S+ R  +  G      T+++     + +I ++ + +Q  G N+C  +NG 
Sbjct: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813

Query: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFL 936
           CS LCLA P G   C C     L+AD  TC A  +++
Sbjct: 814 CSSLCLATP-GSRQCACAEDQVLDADGVTCLANPSYV 849



 Score =  289 bits (740), Expect = 1e-77
 Identities = 145/311 (46%), Positives = 205/311 (65%), Gaps = 7/311 (2%)

Query: 21   PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA--IKRT 78
            P L++ANR  LR ++      N T++  GL +A A+DF +   +IYW+DV+ +   I+R 
Sbjct: 3029 PFLIFANRYYLRKLNLDGS--NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRM 3086

Query: 79   EFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELD 138
              N + +VQ +  +GL +PDGLA DW+G  LYW D   + IEVS L+G+ R VL    L 
Sbjct: 3087 HLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLR 3145

Query: 139  QPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYW 198
            +PRA+ +D  +G++YWTDWG+   I R GMDGSSR +I++++I WPNGLTLDY  +++YW
Sbjct: 3146 EPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYW 3205

Query: 199  ADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGL 258
            ADA+ ++I  ++LDG+NR  V+   +PH FALTLFED +YWTDW T SI   +K TG   
Sbjct: 3206 ADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNK 3265

Query: 259  REIHSDIFSPMDIHAFSQQRQPNATN-PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLL 317
              + S +  PMD+H F   RQP+  N PC ++NGGCS+LCL+SP    ++CACPT   L 
Sbjct: 3266 TLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSP-GGGHKCACPTNFYLG 3324

Query: 318  ENGKTCKDGAT 328
             +G+TC    T
Sbjct: 3325 SDGRTCVSNCT 3335



 Score =  280 bits (717), Expect = 6e-75
 Identities = 150/345 (43%), Positives = 206/345 (59%), Gaps = 14/345 (4%)

Query: 293  CSHLCLMSPVKPFYQCACPTGVKLLENGK-TCKDGATE--LLLLARRTDLRRISLDTPDF 349
            CS  C+ +     Y+C C  G         +CK    E   L+ A R  LR+++LD  ++
Sbjct: 2992 CSQRCINTHGS--YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNY 3049

Query: 350  TDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRA--IRRSFIDGSGSQFVVTAQIAHPDG 407
            T   L  + + +A+A+D+D  E  IYWTD   +   IRR  ++GS  Q +    +++PDG
Sbjct: 3050 T---LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106

Query: 408  IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGE 467
            +AVDWV  NLYW D G D IEV++LNG  R +L+S  L EPRA+V+D   GY+YWTDWG+
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166

Query: 468  IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL 527
               I R  +DGS R V+V+T + WPNGL LDY   +IYW DA+ D IE  + DG+ R V+
Sbjct: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226

Query: 528  VEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREVIIDQLPDLMGLKATNVHRV 586
            +   IPHIF  TL  DYVYWTDW+ +SI R HK +   + ++I  L   M L   +  R 
Sbjct: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQ 3286

Query: 587  --IGSNPCAEENGGCSHLCLYRP-QGLRCACPIGFELISDMKTCI 628
              + ++PC   NGGCS+LCL  P  G +CACP  F L SD +TC+
Sbjct: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331



 Score =  278 bits (711), Expect = 3e-74
 Identities = 146/354 (41%), Positives = 208/354 (58%), Gaps = 12/354 (3%)

Query: 599  CSHLCLYRPQGLRCACPIGFELIS----DMKTCIVPEAFLLFSRRADIRRISLETNNNNV 654
            CS  C+      +C C  G+          K     E FL+F+ R  +R+++L+   +N 
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLD--GSNY 3049

Query: 655  AIPLTGVKEASALDFDVTDNRIYWTDISLK--TISRAFMNGSALEHVVEFGLDYPEGMAV 712
             +   G+  A ALDFD  +  IYWTD++ +   I R  +NGS ++ +   GL  P+G+AV
Sbjct: 3050 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAV 3109

Query: 713  DWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPK 772
            DW+G NLYW D G + IEVSKL+G +R VLV   L  PRAL +D   G++YWT+WG    
Sbjct: 3110 DWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSL 3169

Query: 773  IDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI-AD 830
            I R  MDGS R+ +V   +   NGLT+DY   R+YW D   + IE +++ G NR V+ + 
Sbjct: 3170 IGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQ 3229

Query: 831  DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGW 890
            D+PH F LT ++DY+YWTDW  +SI RA+KT+G N+T++   L   MD+ VFH+ RQ   
Sbjct: 3230 DIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDV 3289

Query: 891  --NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
              + C  +NG CS+LCL  P GG  C CP ++ L +D RTC +  T   F  K+
Sbjct: 3290 PNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKN 3343



 Score =  256 bits (653), Expect = 2e-67
 Identities = 157/481 (32%), Positives = 253/481 (52%), Gaps = 27/481 (5%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYS-LNADNRTCSAPTT---FLLFSQKSAINR 946
            +EC S+   CS  C+    G + C C   Y+    D  +C A T    FL+F+ +  + +
Sbjct: 2984 DEC-STTFPCSQRCINTH-GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRK 3041

Query: 947  MVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWID--SRQNMIRKAQEDGSQGFTVVV 1004
            + +D     +  L    L N  A+D+D  ++ +YW D  ++ +MIR+   +GS      V
Sbjct: 3042 LNLD---GSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSN-----V 3093

Query: 1005 SSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVV 1064
              +    L   P  L++D     +YW  +  + I V++L+G    V++      PRA+VV
Sbjct: 3094 QVLHRTGLS-NPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVV 3152

Query: 1065 NPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLR 1124
            + + GY+Y+T+  + S  I R  +DG+ R V+  + ++ P  L LD    +++WAD+   
Sbjct: 3153 DVQNGYLYWTDWGDHS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARED 3211

Query: 1125 RIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQAR 1184
             IE + L G+NR V+   +I     LT+FE+++YW D + + I +   T    +T + + 
Sbjct: 3212 YIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLIST 3271

Query: 1185 IAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCG 1244
            + +  D+H    L   +   HPC  +NGGCS++CL+   G  +C+CP +  L  D  +C 
Sbjct: 3272 LHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC- 3330

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-LNCP--VCSESQFQCASGQCI 1301
                C+  QF C   +  CIP  W+CD   +C DHSDE  +CP   C   QFQC++G C 
Sbjct: 3331 -VSNCTASQFVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICT 3387

Query: 1302 DGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCAN-GQCIGKHKKCDHNVDCSDKSDELD 1359
            + A  C+GD +CQD SDE NC++ +CL  QF+C N  +CI    +C+   +C D  DE D
Sbjct: 3388 NPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERD 3447

Query: 1360 C 1360
            C
Sbjct: 3448 C 3448



 Score =  192 bits (489), Expect = 2e-48
 Identities = 100/240 (41%), Positives = 138/240 (57%), Gaps = 8/240 (3%)

Query: 86   VQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIAL 145
            V ++ +SGL  P G+A DW+   +YWTDS  + IEV+ + G  RK L    +D+P AI +
Sbjct: 3949 VTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVV 4008

Query: 146  DPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNF 205
            DP  G MYW+DWG  PKIE A MDG+ R  ++   I WP GL +DY  ++LYWADAKL+ 
Sbjct: 4009 DPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 4068

Query: 206  IHKSNLDGTNR--QAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHS 263
            I    L+GT+    A  K  L HPF++ +FED +Y   +  + +   +K+    L  +  
Sbjct: 4069 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4128

Query: 264  DIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTC 323
             +    D+  + Q +QP  TNPC  D   C  LCL+SP  P   C CP G K L+NG TC
Sbjct: 4129 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV--CTCPNG-KRLDNG-TC 4182



 Score =  179 bits (453), Expect = 3e-44
 Identities = 121/361 (33%), Positives = 174/361 (48%), Gaps = 32/361 (8%)

Query: 291  GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATE--LLLLARRTDLRRISLDTPD 348
            G CS LC  +  K  + C+C        N  TCK   +E  +L +A   ++R +    P 
Sbjct: 3832 GTCSQLC--NNTKGGHLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPH 3887

Query: 349  FT-DIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAI----------------RRSFIDG 391
               +   Q ++     A+D     G +YWT+     I                 R  ID 
Sbjct: 3888 SAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDR 3947

Query: 392  SGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAI 451
              +   ++  +  P GIA+DWVA N+YWTD+G D IEV ++ G  RK LIS  ++EP AI
Sbjct: 3948 GVTHLNISG-LKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006

Query: 452  VLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKT 511
            V+DP+ G MYW+DWG  PKIE AA+DG+ R  LV  ++ WP GLA+DY   ++YW DAK 
Sbjct: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066

Query: 512  DKIEVMNTDGTGRRVLVEDK--IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREV-I 568
              I  +  +GT   V  + K  + H F   +  DY+Y   +    + ++HK      V +
Sbjct: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126

Query: 569  IDQLPDLMGLKATNVHRVIG-SNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
               L     +   + H+    +NPC  +   C  LCL  P G  C CP G  L  D  TC
Sbjct: 4127 TGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPNGKRL--DNGTC 4182

Query: 628  I 628
            +
Sbjct: 4183 V 4183



 Score =  177 bits (448), Expect = 1e-43
 Identities = 123/376 (32%), Positives = 177/376 (47%), Gaps = 37/376 (9%)

Query: 584  HRVIGSNPCAEEN-----GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSR 638
            H V G   C + N     G CS LC     G  C+C   F  +    TC    +      
Sbjct: 3814 HTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNF--MKTHNTCKAEGSEYQVLY 3871

Query: 639  RADIRRI-SLETNNNNVAIPLTGVKEAS----ALDFDVTDNRIYWTDISLKTISRAFMNG 693
             AD   I SL   + + A       + S    A+D  V   R+YWT+    TIS   +  
Sbjct: 3872 IADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPP 3931

Query: 694  SA---------------LEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
            +A               + H+   GL  P G+A+DW+  N+YW D+G + IEV+++ G++
Sbjct: 3932 AAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGEN 3991

Query: 739  RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 797
            R+ L+   +D P A+ +DP  G MYW++WG  PKI+ AAMDG+ R TLV  N+    GL 
Sbjct: 3992 RKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLA 4051

Query: 798  IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRS 854
            +DY   RLYW D   ++I S  + G +  V AD    L HPF +  ++DYIY   +    
Sbjct: 4052 VDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNR 4111

Query: 855  IERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASSNGHCSHLCLAVPVGGFV 913
            + + +K        + G L +  D++++H  +Q    N C      C  LCL  P  G V
Sbjct: 4112 VFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSP-SGPV 4168

Query: 914  CGCPAHYSLNADNRTC 929
            C CP    L  DN TC
Sbjct: 4169 CTCPNGKRL--DNGTC 4182



 Score =  134 bits (336), Expect = 9e-31
 Identities = 106/408 (25%), Positives = 173/408 (42%), Gaps = 63/408 (15%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPT----------------- 933
            ++C+ +NG CSH C   P  G VC CP    L  DN TC   +                 
Sbjct: 1183 DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKF 1242

Query: 934  --------------------------TFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
                                       F++FS +  I R+   +    D  + +  LRN 
Sbjct: 1243 SVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRI---DLHKGDYSVLVPGLRNT 1299

Query: 968  RAIDYDPLDKQLYWIDSRQNMIRKAQ--EDGS-QGFTVVVSSVPSQNLEIQPYDLSIDIY 1024
             A+D+      LYW D  ++ I + +  ++G+   F VV+     Q     P  L++D  
Sbjct: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVI-----QYGLATPEGLAVDWI 1354

Query: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
            +  IYW     + I V +LDG     +L G+ + PRA+ ++P  G +++T+     P+IE
Sbjct: 1355 AGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIE 1414

Query: 1085 RAALDGTEREVLFFSGLSK--PIALALDSRLGKLFWADSDLRRIESS--DLSGANRIVLE 1140
             A++ G  R  +     S   P  L +D    ++ W D+    I S+  D SG   ++  
Sbjct: 1415 AASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRG 1474

Query: 1141 DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
               +  P  +T++   +YW D +   + K +       T VQ    Q  D+  V   + Q
Sbjct: 1475 HEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQ-VYHPSRQ 1533

Query: 1201 EYRQHPCAQDNGG---CSHICLVKGDGTTRCSCPMHLVLLQDELSCGE 1245
                +PC + NGG   CSH+CL+  + T  C+CP  + L +D  +C E
Sbjct: 1534 PMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYE 1580



 Score =  124 bits (310), Expect = 1e-27
 Identities = 115/416 (27%), Positives = 170/416 (40%), Gaps = 46/416 (11%)

Query: 968  RAIDYDPLDKQLYWID-------SRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS 1020
            RAI  DPL+  +YW D       SR+  + +A  DGS     V S        + P  LS
Sbjct: 651  RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTV-----LWPNGLS 705

Query: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
            +DI +  +YW     + I    L+G    +V +G +    A  +     Y+++T  +  S
Sbjct: 706  LDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN-HAFGLCHHGNYLFWTEYRSGS 764

Query: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRL--GKLFWADSDLRRIESSDLS------ 1132
                   + G    V        PI    + R+   +     ++  R+ +   S      
Sbjct: 765  VYRLERGVGGAPPTVTLLRSERPPI---FEIRMYDAQQQQVGTNKCRVNNGGCSSLCLAT 821

Query: 1133 -GANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGR--EGRTKVQARIAQLS 1189
             G+ +    +  +L   G+T   N  Y    Q Q  E      R  + R K       L 
Sbjct: 822  PGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLD 881

Query: 1190 DIHAVKELNLQEYRQHPCAQDNGGCSHICLVKG----DGTTRCSCPMHLVLLQDELSCGE 1245
            +      L      QH C  D   C +   +      DG   C         +   +C  
Sbjct: 882  NSDEAPAL----CHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED----ESNATCSA 933

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-LNC--PVCSE-SQFQCASGQCI 1301
              TC P QF+C +G   CIP++W CD   +C D SDE  +C  P C   +QF C +G+CI
Sbjct: 934  R-TCPPNQFSCASGR--CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCI 990

Query: 1302 DGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            +   RC+ D +C D SDE  C   C   QF+C +G+CI +H  CD + DC D SDE
Sbjct: 991  NINWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1046



 Score =  121 bits (304), Expect = 5e-27
 Identities = 55/115 (47%), Positives = 72/115 (62%), Gaps = 4/115 (3%)

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCIDGAL 1305
            TC P QF C      C+P  W+CD   +C D+SDE +C    CSES+F CA+G+CI G  
Sbjct: 3535 TCEPYQFRCKNNR--CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592

Query: 1306 RCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            +C+GD +C D SDEK+C   C +DQF+C +G CI    +CD + DC D SDE  C
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647



 Score =  113 bits (283), Expect = 1e-24
 Identities = 78/248 (31%), Positives = 122/248 (49%), Gaps = 14/248 (5%)

Query: 1016 PYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTN 1075
            P  ++ID  +  +YWT    +VI V ++ G +   ++ G  D P A+VV+P +G MY+++
Sbjct: 3960 PRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSD 4019

Query: 1076 LQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN 1135
                 PKIE AA+DGT RE L    +  P  LA+D    +L+WAD+ L  I S  L+G +
Sbjct: 4020 WGNH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD 4078

Query: 1136 RIVLEDS--NILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1193
             IV  DS   +  P  + VFE+++Y +      + KI   G      +   ++  SD+  
Sbjct: 4079 PIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDV-V 4137

Query: 1194 VKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC-----GEPPT 1248
            +   + Q    +PC  D   C  +CL+   G   C+CP    L  D  +C       PP 
Sbjct: 4138 LYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-CTCPNGKRL--DNGTCVPVPSPTPPP 4192

Query: 1249 CSPQQFTC 1256
             +P+  TC
Sbjct: 4193 DAPRPGTC 4200



 Score =  108 bits (270), Expect = 4e-23
 Identities = 57/123 (46%), Positives = 68/123 (55%), Gaps = 7/123 (5%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC-PVCSESQFQCAS 1297
            DE SC  P  CS  +F+C  G   CI   W+CDG  +C D SDE +C P C   QFQC S
Sbjct: 3566 DEESC-TPRPCSESEFSCANGR--CIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS 3622

Query: 1298 GQCIDGALRCNGDANCQDKSDEKNCEV---LCLIDQFRCANGQCIGKHKKCDHNVDCSDK 1354
            G CI    RC+ DA+C D SDE+ C      C +D+F+C N  C     KCD   DC D 
Sbjct: 3623 GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDN 3682

Query: 1355 SDE 1357
            SDE
Sbjct: 3683 SDE 3685



 Score =  103 bits (256), Expect = 2e-21
 Identities = 54/129 (41%), Positives = 70/129 (54%), Gaps = 13/129 (10%)

Query: 1245 EPPTCSPQQFTCFTGEIDC------IPVAWRCDGFTECEDHSDELN--CP--VCSESQFQ 1294
            EP  C+  Q TC   E  C      IP  W+CDG  +C D SDE    C    C   QF+
Sbjct: 3485 EPANCT--QMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSD 1353
            C + +C+ G  +C+ D +C D SDE++C    C   +F CANG+CI    KCD + DC+D
Sbjct: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCAD 3602

Query: 1354 KSDELDCYP 1362
             SDE DC P
Sbjct: 3603 GSDEKDCTP 3611



 Score =  102 bits (253), Expect = 4e-21
 Identities = 56/134 (41%), Positives = 71/134 (52%), Gaps = 14/134 (10%)

Query: 1239 DELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCA 1296
            DE +    PTC P  QFTC  G   CI + WRCD   +C D+SDE  C   CS +QF+C 
Sbjct: 966  DESASCAYPTCFPLTQFTCNNGR--CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCN 1023

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL---------CLIDQFRCA-NGQCIGKHKKCD 1346
            SG+CI     C+GD +C D SDE +             C  D+F+C  +G CI    +CD
Sbjct: 1024 SGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCD 1083

Query: 1347 HNVDCSDKSDELDC 1360
             + DC D SDE  C
Sbjct: 1084 GDTDCMDSSDEKSC 1097



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 68/179 (37%), Positives = 83/179 (46%), Gaps = 38/179 (21%)

Query: 1210 DNGGCSHICLVKGDGTTRCSC------PMHLVLLQDELSCGE----------------PP 1247
            D  GCSH C      +T+  C      P H     D   CG+                P 
Sbjct: 1007 DEAGCSHSC-----SSTQFKCNSGRCIPEHWTCDGDN-DCGDYSDETHANCTNQATRPPG 1060

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSES-QFQCA-SGQCI 1301
             C   +F C    + CIP+ WRCDG T+C D SDE +C     VC  S +F C  S +CI
Sbjct: 1061 GCHTDEFQCRLDGL-CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCI 1119

Query: 1302 DGALRCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQ--CIGKHKKCDHNVDCSDKSDE 1357
              A  C+GD +C+D SDE+NCE L C      CAN    C+   K CD N DC D SDE
Sbjct: 1120 SKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 62/155 (40%), Positives = 76/155 (49%), Gaps = 25/155 (16%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCPV--------C 1288
            DE  C    +CS  QF C +G   CIP  W CDG  +C D+SDE   NC          C
Sbjct: 1007 DEAGCSH--SCSSTQFKCNSGR--CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGC 1062

Query: 1289 SESQFQCA-SGQCIDGALRCNGDANCQDKSDEKNCE-VLCLID---QFRCANG-QCIGKH 1342
               +FQC   G CI    RC+GD +C D SDEK+CE V  + D   +F C +  +CI K 
Sbjct: 1063 HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKA 1122

Query: 1343 KKCDHNVDCSDKSDE-----LDCYPTEEPAPQATN 1372
              CD + DC D SDE     L C P   P    T+
Sbjct: 1123 WVCDGDNDCEDNSDEENCESLACRPPSHPCANNTS 1157



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 57/133 (42%), Positives = 75/133 (56%), Gaps = 12/133 (9%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
            DE +C +   C P QF C T    CIP  +RC+G   C D  DE +CP   C+ +QFQC+
Sbjct: 3404 DEANC-DIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCS 3461

Query: 1297 -SGQCIDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCS 1352
             + +CI     C+ D +C D SDE  NC ++ C +D+FRC  +G+CI    KCD   DC 
Sbjct: 3462 ITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCG 3521

Query: 1353 DKSDELDCYPTEE 1365
            D SDE    P EE
Sbjct: 3522 DGSDE----PKEE 3530



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 40/100 (40%), Positives = 54/100 (54%), Gaps = 5/100 (5%)

Query: 1263 CIPVAWRCDGFTECEDHSDELNCPV-----CSESQFQCASGQCIDGALRCNGDANCQDKS 1317
            C   +W CDG  +C D+SDE +CP      C  + F C SG+CI  +  C+ + +C+   
Sbjct: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGE 2725

Query: 1318 DEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            DE +C   C   QF C N +CI K   CD + DC D SDE
Sbjct: 2726 DETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 60/180 (33%), Positives = 79/180 (43%), Gaps = 53/180 (29%)

Query: 1239 DELSCG--EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC-PVCSESQFQC 1295
            DE  C   + P C    F C +G   CIP++W CD   +CE   DE +C   CSE+QF+C
Sbjct: 2684 DERDCPGVKRPRCPLNYFACPSGR--CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFEC 2741

Query: 1296 ASGQCIDGALRCNGDANCQDKSDEK-NCE------------------------------- 1323
             + +CI     C+G  +C D SDE  +CE                               
Sbjct: 2742 QNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCA 2801

Query: 1324 --------VLCLID------QFRCANGQCIGKHKKCDHNVDCSDKSDEL-DC-YPTEEPA 1367
                      CL +      +F C N QCI KH  CDH+ DC+D SDE  +C YPT  P+
Sbjct: 2802 DGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPS 2861



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 16/160 (10%)

Query: 1227 RCSCPMHLVLLQDELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-- 1283
            RC      +   DE +CG    TC   +F C      C P+AW+CDG  +C D+SDE   
Sbjct: 3631 RCDADADCMDGSDEEACGTGVRTCPLDEFQC--NNTLCKPLAWKCDGEDDCGDNSDENPE 3688

Query: 1284 NCP--VCSESQ-FQCASGQ-CIDGALRCNGDANCQDKSDEKNCEVLCLID-------QFR 1332
             C   VC  ++ F+C + + C+    +C+G  NC D +DE++CE             +F 
Sbjct: 3689 ECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFL 3748

Query: 1333 CANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATN 1372
            C N +C+    +C+   DC D SDE DC    +    ATN
Sbjct: 3749 CRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 3788



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 54/157 (34%), Positives = 71/157 (45%), Gaps = 21/157 (13%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVA-WRCDGFTECEDHSDEL-NCPVCSE------ 1290
            DE    E PTC P +F C  G   C+    W CDG  +C D SDE    P C+       
Sbjct: 2848 DESPECEYPTCGPSEFRCANGR--CLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN 2905

Query: 1291 --SQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQC----IGKHK 1343
              SQF C+SG+C+  AL CNG  +C D SDE+ C +  CL  +    +  C    IG   
Sbjct: 2906 ASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKC 2965

Query: 1344 KCDHNVDCSDK----SDELDCYPTEEPAPQATNTVGS 1376
            +C       D     +D  +C  T   + +  NT GS
Sbjct: 2966 RCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGS 3002



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 44/125 (35%), Positives = 55/125 (44%), Gaps = 23/125 (18%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN--CPV-----CSESQFQCASG 1298
            P TCSP+QF C   +I CI   WRCDG  +C D SDE    CP      C  ++  C   
Sbjct: 24   PKTCSPKQFAC-RDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT 82

Query: 1299 Q-CIDGALRCNGDANCQDKSDE-KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
            + C+  +  CNG  +C D SDE  +C  L          G C      C H+  C    D
Sbjct: 83   ELCVPMSRLCNGVQDCMDGSDEGPHCREL---------QGNC--SRLGCQHH--CVPTLD 129

Query: 1357 ELDCY 1361
               CY
Sbjct: 130  GPTCY 134



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 43/118 (36%), Positives = 52/118 (44%), Gaps = 12/118 (10%)

Query: 1227 RCSCPMHLVLLQDELSC-GEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDELN 1284
            RC      +   DE SC G    C P  +F C      CI  AW CDG  +CED+SDE N
Sbjct: 1081 RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC-KDSARCISKAWVCDGDNDCEDNSDEEN 1139

Query: 1285 CP--VCSESQFQCASGQ--CIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQC 1338
            C    C      CA+    C+     C+G+ +C D SDE       L DQ    NG C
Sbjct: 1140 CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGE-----LCDQCSLNNGGC 1192



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 27/99 (27%), Positives = 46/99 (46%)

Query: 29   RDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQN 88
            RD+  V    G+   T++ G +++  A+      G +YWSD        T        + 
Sbjct: 3979 RDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRET 4038

Query: 89   VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
            +V   +  P GLA D+  E+LYW D++ + I    L+G+
Sbjct: 4039 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGT 4077



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 43/147 (29%), Positives = 61/147 (41%), Gaps = 16/147 (10%)

Query: 1055 EQDRPRAVVVNPEKGYMYFTN-----LQERS--PKIERAALDGTEREV------LFFSGL 1101
            E  R  A+ V+ + G +Y+TN     +  RS  P       +   R++      L  SGL
Sbjct: 3898 ESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGL 3957

Query: 1102 SKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTV--FENWLYW 1159
              P  +A+D   G ++W DS    IE + + G NR  L    I +P  + V      +YW
Sbjct: 3958 KMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYW 4017

Query: 1160 ID-KQQQMIEKIDMTGREGRTKVQARI 1185
             D      IE   M G    T VQ  I
Sbjct: 4018 SDWGNHPKIETAAMDGTLRETLVQDNI 4044



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 17/44 (38%), Positives = 23/44 (52%)

Query: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS 1250
            C+ +NGGCSH C V       CSCP+ + L  D  +C     C+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCA 1228


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score =  764 bits (1974), Expect = 0.0
 Identities = 463/1391 (33%), Positives = 743/1391 (53%), Gaps = 72/1391 (5%)

Query: 23   LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNK 82
            ++++ R ++R +D    K + +++V GL +  A+DF F+  L+YW+DV E+ I R + ++
Sbjct: 1262 IIFSIRHEIRRIDLH--KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319

Query: 83   T---ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
            +    +++ VV  GL +P+GL  DW+   +YW DS  ++IEV+ LDGSLR  L    ++ 
Sbjct: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEH 1379

Query: 140  PRAIALDPSSGFMYWTDW-GEVPKIERAGMDGSSRFIIIN--SEIYWPNGLTLDYEEQKL 196
            PRAIALDP  G ++WTDW    P+IE A M G+ R  I        WPNGLT+D+ E+++
Sbjct: 1380 PRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRI 1439

Query: 197  YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
             W DA+ + I+ +  DGTN   +++G   L HPFA++L+   +YWTDW T+++   NK+T
Sbjct: 1440 VWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWT 1499

Query: 255  GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDN--GGCSHLCLMSPVKPFYQCACPT 312
            G+ +  I      P D+  +   RQP A NPC  ++  G CSH+CL++  +    CACP 
Sbjct: 1500 GQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRS-AACACPH 1558

Query: 313  GVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDI-VLQLEDIRHAIAIDYDPVE 371
             +KL  + KTC +   + LL ARR+++R + +D P F  I    + DI     ID+D  E
Sbjct: 1559 LMKLSSDKKTCYE-MKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASE 1617

Query: 372  GYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTD--RIEV 429
              +YWTD + + I+R+FI+G+G + V++  I    G+AVDWV+RNLYW  +  D  +I V
Sbjct: 1618 ERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINV 1677

Query: 430  TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489
             RL+G+++  +I   +++P+ +   P+ G +YWTD      I  A +DGS+  +L     
Sbjct: 1678 ARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTDGN---TINMANMDGSNSKILFQNQK 1733

Query: 490  GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL--VEDKIPHIFGFTLLGDYVYW 547
              P GL++DY E K+YW  +    I   N DG    V+  +++++      T++   ++W
Sbjct: 1734 E-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWW 1792

Query: 548  TDWQRRSIERVHKRSAEREVII-DQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYR 606
             D     +    KR      I+ ++   ++ +K  +     GSN C   NGGCS LCL  
Sbjct: 1793 ADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPT 1852

Query: 607  PQGLR-CACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNN-NVAIPLTGVKEA 664
             +  R C C +G+ L  +  +C   E+FL++S    IR I LE ++  +  +P++G   A
Sbjct: 1853 SETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFA 1912

Query: 665  SALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADT 724
              +DF   ++ IYWTD+    ISRA  + +  E ++  GL   EG+AVDW+  N+YW D 
Sbjct: 1913 VGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDH 1972

Query: 725  GTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERT 784
            G N IEV++L+G  R V++ + LD PR++A+ P +G ++WTEWG  P I +A +DGSE+ 
Sbjct: 1973 GFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKV 2032

Query: 785  TLVP-NVGRANGLTIDYAKRRLYWTDLDTNLIESSNM-LGLNRE-VIADDLPHPFGLTQY 841
             LV   +   NG++IDY + +LYW D  T+ IE  ++  G NRE V++      F +  +
Sbjct: 2033 VLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVF 2092

Query: 842  QDYIYWTD--WSRRSIERANKTSGQNRTIIQGHLDY-VMDILVFHSSRQSGWNECASSNG 898
              YIYW+D   +  S+ R +K        ++  L   + ++ +F+  R+ G N CA  NG
Sbjct: 2093 GAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNG 2152

Query: 899  HCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDII 958
             C  LCL        C C AH  L  D  TC     +LL+S ++ +  + + ++   ++ 
Sbjct: 2153 GCKQLCLYRGNSRRTCAC-AHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDE--TNLN 2209

Query: 959  LPIHSLRNVR--------AIDYDPLDK---QLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
             PI    N R        A DY+   K   ++++ D+    I+   +D  +   V+V +V
Sbjct: 2210 SPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLI-KDNWEDRQVIVENV 2268

Query: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG------VVLKGEQDRPRA 1061
             S  +E   Y  + D     +YWT   T+ I    +D    G      V+   E D P  
Sbjct: 2269 GS--VEGLAYHRAWDT----LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHV 2322

Query: 1062 VVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADS 1121
            + ++  +  M++TN  E+ P I R+ L G   +V+  + +  P  L +D R  KL+++D 
Sbjct: 2323 LALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDG 2382

Query: 1122 DLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWID-KQQQMIEKIDMTGREGRTK 1180
             L +IE  +  G+ R V+  S     + L V++N+++W D  ++ ++     TG  G TK
Sbjct: 2383 SLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTG--GDTK 2440

Query: 1181 VQARIAQLSDIHAVKELN-LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD 1239
            +         +  +   N        PCA  NGGC  +CL+  +G   CSC    +LL+D
Sbjct: 2441 ILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLED 2500

Query: 1240 ELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCP--VCSESQFQ 1294
                 +  +C+   +F C  GE  CI     CDG   C+D SDE  L C    C      
Sbjct: 2501 NRCVTKNSSCNAYSEFECGNGE--CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKP 2558

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSD 1353
            C + +CI     C+G+ +C D SDE +C+V  C   +FRCA+G CI +  +C+ N+DC+D
Sbjct: 2559 CYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCAD 2618

Query: 1354 KSDELDCYPTE 1364
             SDE +C  T+
Sbjct: 2619 ASDEKNCNNTD 2629



 Score =  520 bits (1339), Expect = e-147
 Identities = 319/1026 (31%), Positives = 517/1026 (50%), Gaps = 87/1026 (8%)

Query: 286  CGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK--------------------- 324
            C ++NGGCS+ C + P +    C+CP G++L ++ KTC+                     
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIV-CSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234

Query: 325  ---------------------DGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
                                 D     ++ + R ++RRI L   D++   L +  +R+ I
Sbjct: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYS---LLVPGLRNTI 1291

Query: 364  AIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNLYW 419
            A+D+   +  +YWTD     I R  +  SG     + VV   +A P+G+ VDW+A N+YW
Sbjct: 1292 ALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYW 1351

Query: 420  TDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW-GEIPKIERAALDG 478
             D+  D+IEV +L+G++R  LI+  +E PRAI LDP  G ++WTDW    P+IE A++ G
Sbjct: 1352 IDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSG 1411

Query: 479  SDRVVLVN--TSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV--EDKIPH 534
            + R  +     +  WPNGL +D+ E +I W DA++D I     DGT    ++   + + H
Sbjct: 1412 AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471

Query: 535  IFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLP----DLMGLKATNVHRVIGSN 590
             F  +L G  VYWTDW+  ++ + +K + +   +I +      DL     +   +    N
Sbjct: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQ--APN 1529

Query: 591  PCA--EENGGCSHLCLY-RPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL 647
            PCA  +  G CSH+CL    +   CACP   +L SD KTC   + FLL++RR++IR + +
Sbjct: 1530 PCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDI 1589

Query: 648  ETNNNN--VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705
            +    N   A  +  + + + +DFD ++ R+YWTDI  +TI RAF+NG+ LE V+   + 
Sbjct: 1590 DNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQ 1649

Query: 706  YPEGMAVDWLGKNLYW--ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMY 763
               G+AVDW+ +NLYW  ++    +I V++LDG  +  ++   +D P+ LA  P  G +Y
Sbjct: 1650 SIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLY 1708

Query: 764  WTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGL 823
            WT+      I+ A MDGS    L  N     GL+IDY + +LYW       I   N+ G 
Sbjct: 1709 WTDGN---TINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGG 1765

Query: 824  NREVI---ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDIL 880
            N EVI    ++L     LT     ++W D +   +   +K  G+N TI++     V+ + 
Sbjct: 1766 NLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMK 1825

Query: 881  VFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQ 940
            V+    Q G N C  +NG CS LCL        C C   Y L  +  +C    +FL++S 
Sbjct: 1826 VYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSV 1885

Query: 941  KSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGF 1000
               I  + ++     D ++PI        ID+   +  +YW D   N I +A+ D +   
Sbjct: 1886 HEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKE 1945

Query: 1001 TVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPR 1060
             ++ + +       +   +++D  +  IYWT    N+I V RL+G    V++    D+PR
Sbjct: 1946 DIITNGLG------RVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPR 1999

Query: 1061 AVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWAD 1120
            ++ V+PEKG +++T   +  P I +A LDG+E+ VL   G++ P  +++D    KL+W D
Sbjct: 2000 SIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCD 2058

Query: 1121 SDLRRIESSDL-SGANR-IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGR 1178
            +   +IE  DL +G NR +VL  SN+     + VF  ++YW D+             +  
Sbjct: 2059 ARTDKIERIDLETGGNREMVLSGSNV-DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDAT 2117

Query: 1179 TKVQARIAQLSDIHAVKELN-LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLL 1237
              +  R     ++  VK  N ++E   + CA+DNGGC  +CL +G+    C+C  H  L 
Sbjct: 2118 ETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCAC-AHGYLA 2176

Query: 1238 QDELSC 1243
            +D ++C
Sbjct: 2177 EDGVTC 2182



 Score =  353 bits (906), Expect = 7e-97
 Identities = 215/634 (33%), Positives = 340/634 (53%), Gaps = 31/634 (4%)

Query: 21  PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA--IKRT 78
           P+LL AN   +  V   NG + AT+      +   +DF+++  +I W +  E +  +K  
Sbjct: 204 PILLIANFETIE-VFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCI 262

Query: 79  EFNKTESVQNVVVSGLLSP----DGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFW 134
           +  K   + +     +L        +A DWL   LY+ D   +RI V N +GS+   L  
Sbjct: 263 QITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLID 322

Query: 135 QELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQ 194
            EL  P+AIA+DP +G +++TD+G V K+ER  MDG +R  II+S+   P  L LD   +
Sbjct: 323 LELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNK 382

Query: 195 KLYWADAKLNFIHKSNLDGTNRQAVVKG-SLPHPFALTLFEDILYWTDWSTHSILACNKY 253
            +YW D  L+++   +  G NR  V++G  + H + +T+FED LY T+   ++I+  N++
Sbjct: 383 LVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRF 442

Query: 254 TGEGLREIHS--DIFSPMDIHAFSQQRQPNA-TNPCGID----NGGCSHLCLMSPVKPFY 306
            G    +IHS   I +   I  + ++ QP   ++ C +D     GGCSH+CL+S      
Sbjct: 443 NG---TDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTR 499

Query: 307 QCACPTGVKLLENGKTCKDGATELLLL---ARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
            C C TG  L  +G++CK    EL L     R   +R + L+T    + ++ +E++ +  
Sbjct: 500 TCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPR 559

Query: 364 AIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTG 423
           A+D+     YIY+ D     I R  IDG+  + ++   + + +GIAVDW+  NLYWT+ G
Sbjct: 560 ALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDG 619

Query: 424 TDR-IEVTRLN--GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGE------IPKIERA 474
             + I V RL      RK L+  ++  PR IV+DP+ G+MYWTDW E      + +IE+A
Sbjct: 620 HRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKA 679

Query: 475 ALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK-IP 533
            +DG +R + V + + WPNGL LD+    +YW DA  D IE +  +GT R+++   + + 
Sbjct: 680 WMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739

Query: 534 HIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCA 593
           H FG +  G+YV+WTD+   SI ++   ++E  ++  + P L GL+  +  +  G N C 
Sbjct: 740 HPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCR 799

Query: 594 EENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
             NGGCS LCL  P G  CAC     L  +  TC
Sbjct: 800 VNNGGCSTLCLAIPGGRVCACADNQLLDENGTTC 833



 Score =  312 bits (799), Expect = 2e-84
 Identities = 235/824 (28%), Positives = 390/824 (47%), Gaps = 65/824 (7%)

Query: 597  GGCSHLCLYRPQGLRCACPIGFELISDMKTC---IVPEAFLLFSRRADIRRISLETNNNN 653
            G CS  C        C+C  G+ +  D ++C   I P         A+   I +   N +
Sbjct: 163  GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222

Query: 654  VAIPLTGVK--EASALDFDVTDNRIYWTDI-----SLKTISRAFMNGSALEHVVEFGLDY 706
                L+ V   E   LDF   ++ I W +       LK I      G   E  +     +
Sbjct: 223  KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 282

Query: 707  P--EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYW 764
               + MA+DWL +NLY+ D   +RI V   +G     L+  +L +P+A+A+DP  G +++
Sbjct: 283  HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFF 342

Query: 765  TEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGL 823
            T++G   K++R  MDG  RT ++ +   +   L +D   + +YW DL  + +   +  G 
Sbjct: 343  TDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGK 402

Query: 824  NREVIAD--DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN-RTIIQGHLDYVMDIL 880
            NR  +     + H +G+T ++DY+Y T+    +I R N+ +G +  ++I+  ++    I 
Sbjct: 403  NRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK--IENAWGIR 460

Query: 881  VFHSSRQSGWNECA------SSNGHCSHLC-LAVPVGGFVCGCPAHYSLNADNRTCSAPT 933
            ++    Q      A         G CSH+C L+       C C   ++L +D R+C  P 
Sbjct: 461  IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPK 520

Query: 934  T--FLLF--SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI 989
               FL +   +   +  M ++ + + + ++PI +L N RA+D+      +Y+ D+   +I
Sbjct: 521  NELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLI 580

Query: 990  RKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA-TNVINVTRLD--GR 1046
             + + DG++  T++   +   N+E     +++D     +YWT +     INV RL+   +
Sbjct: 581  GRQKIDGTERETILKDDL--DNVE----GIAVDWIGNNLYWTNDGHRKTINVARLEKASQ 634

Query: 1047 SVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS-----PKIERAALDGTEREVLFFSGL 1101
            S   +L+GE   PR +VV+P  G+MY+T+ +E        +IE+A +DG  R++   S +
Sbjct: 635  SRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKM 694

Query: 1102 SKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQPVGLTVFENWLYWI 1160
              P  L LD     L+W D+    IE   L+G +R IV     +  P GL+   N+++W 
Sbjct: 695  LWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWT 754

Query: 1161 DKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLV 1220
            D     I ++D+   E  T ++     L  +        Q    + C  +NGGCS +CL 
Sbjct: 755  DYMNGSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQ--GDNMCRVNNGGCSTLCLA 811

Query: 1221 KGDGTTRCSCPMHLVLLQDELSC----GE--PPTCSPQQFTCFTGEIDCIPVAWRCDGFT 1274
               G   C+C  + +L ++  +C    GE  P  C   +F C      CI   W+CDG  
Sbjct: 812  IPGGRV-CACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRH--CIQARWKCDGDD 868

Query: 1275 ECEDHSDE--LNC--PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKN--CEV-LCL 1327
            +C D SDE  +NC    C + QF+C + +CI     C+G  +C    DE N  C    C 
Sbjct: 869  DCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQ 928

Query: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDEL-DC-YPTEEPAPQ 1369
            +DQF C NG+CI +   CD   DC D++DE+  C +PT EP  Q
Sbjct: 929  VDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ 972



 Score =  304 bits (778), Expect = 5e-82
 Identities = 198/678 (29%), Positives = 344/678 (50%), Gaps = 44/678 (6%)

Query: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK-----DGATELLLLARRTDLRRISLD 345
           G CS  C  +     Y C+C  G  +  + ++CK          +LL+A    +    L+
Sbjct: 163 GTCSQTCRNTHGS--YTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220

Query: 346 TPDFTDIVLQLEDIRHAIAIDYDPVEGYIYW-----TDDEVRAIRRSFIDGSGSQFVVT- 399
                 +     +  H +   Y+  E  I W     + ++++ I+ +   G   ++ +  
Sbjct: 221 GSKMATLSSVNGNEIHTLDFIYN--EDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278

Query: 400 -AQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVG 458
                +   +A+DW+ RNLY+ D   DRI V   NG++   LI  +L  P+AI +DP+ G
Sbjct: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338

Query: 459 YMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMN 518
            +++TD+G + K+ER  +DG +R  ++++    P  LALD     +YW D   D + V++
Sbjct: 339 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 398

Query: 519 TDGTGRRVLVEDK-IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMG 577
             G  R  +++ + + H++G T+  DY+Y T+    +I R+++ +      + ++ +  G
Sbjct: 399 YQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWG 458

Query: 578 LK--ATNVHRVIGSNPCAEE----NGGCSHLCLYRP--QGLRCACPIGFELISDMKTCIV 629
           ++         + S+ C  +     GGCSH+CL     +   C C  GF L SD ++C  
Sbjct: 459 IRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKR 518

Query: 630 P--EAFLLF--SRRADIRRISLETN-NNNVAIPLTGVKEASALDFDVTDNRIYWTDISLK 684
           P  E FL +   R   +R + L T   +   IP+  +    ALDF    N IY+ D +  
Sbjct: 519 PKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSF 578

Query: 685 TISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLD--GQHRQV 741
            I R  ++G+  E +++  LD  EG+AVDW+G NLYW + G  + I V++L+   Q R+ 
Sbjct: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638

Query: 742 LVWKDLDSPRALALDPAEGFMYWTEW------GGKPKIDRAAMDGSERTTLVPN-VGRAN 794
           L+  ++  PR + +DP  G+MYWT+W          +I++A MDG  R   V + +   N
Sbjct: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698

Query: 795 GLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI--ADDLPHPFGLTQYQDYIYWTDWSR 852
           GLT+D+    LYW D   + IE   + G +R+++    +L HPFGL+ + +Y++WTD+  
Sbjct: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758

Query: 853 RSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGF 912
            SI + +  + +  T+++     +  + ++   +Q G N C  +NG CS LCLA+P GG 
Sbjct: 759 GSIFQLDLITSE-VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIP-GGR 816

Query: 913 VCGCPAHYSLNADNRTCS 930
           VC C  +  L+ +  TC+
Sbjct: 817 VCACADNQLLDENGTTCT 834



 Score =  245 bits (625), Expect = 3e-64
 Identities = 152/482 (31%), Positives = 249/482 (51%), Gaps = 32/482 (6%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADN----RTCSAPTTFLLFSQKSAINR 946
            +EC SS   CS  C+    G + C C   Y +  DN    ++ S    FL+ +    I +
Sbjct: 2970 DEC-SSGFPCSQQCINT-YGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRK 3027

Query: 947  MVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQ---NMIRKAQEDGSQGFTVV 1003
            +  D     +  L    L NV AID+D  ++ +YWIDS +   + I +   +GS    V 
Sbjct: 3028 ISTD---GSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVH 3084

Query: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVV 1063
             ++VP+         L++D   + +YW+     +I V++L+G    +++      PR + 
Sbjct: 3085 NTAVPNA--------LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLS 3136

Query: 1064 VNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL 1123
            ++P+ GY+Y+ +  E  P I R  +DGT + V+  + +S+P+AL +D    +L+WAD + 
Sbjct: 3137 LDPQAGYLYWIDCCEY-PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN- 3194

Query: 1124 RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQA 1183
              IE S++ G++R  + + +I   + LT+FE+++YW D + + + +   T    R  +  
Sbjct: 3195 -HIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIY 3253

Query: 1184 RIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC 1243
                ++DI         +  +H C  +NGGCSH+CL+    T  C+CP +  L  D  +C
Sbjct: 3254 SWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC 3313

Query: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-NCPV--CSESQFQCASGQC 1300
                 C+  QF C T +  CIP  W+CD   +C D SDE  +CP   C   +FQC +G C
Sbjct: 3314 --LSNCTASQFRCKTDK--CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLC 3369

Query: 1301 IDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCA-NGQCIGKHKKCDHNVDCSDKSDEL 1358
               A  C+G+ +C D SDE NC+  +CL  QF+C  N +CI  + +C+   DC D+ DE 
Sbjct: 3370 ALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDER 3429

Query: 1359 DC 1360
            DC
Sbjct: 3430 DC 3431



 Score =  241 bits (615), Expect = 4e-63
 Identities = 142/355 (40%), Positives = 198/355 (55%), Gaps = 17/355 (4%)

Query: 599  CSHLCLYRPQGLRCACPIGFELISD----MKTCIVPEAFLLFSRRADIRRISLETNNNNV 654
            CS  C+      +C C  G+E+  D     K+    E FL+ +   +IR+IS  T+ +N 
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 3035

Query: 655  AIPLTGVKEASALDFDVTDNRIYWTDISLKT---ISRAFMNGSALEHVVEFGLDYPEGMA 711
             +   G+    A+DFD  +  IYW D S      I+R  +NGS ++ V    +  P  +A
Sbjct: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALA 3093

Query: 712  VDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKP 771
            VDW+GKNLYW+DT    IEVSKL+G +  +LV K L  PR L+LDP  G++YW +    P
Sbjct: 3094 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 3153

Query: 772  KIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIAD 830
             I R  MDG+ ++ ++   + R   LTIDY  RRLYW   D N IE SNM G +R  + +
Sbjct: 3154 HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPN 3211

Query: 831  -DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSG 889
             D+P    LT ++DYIYWTD   +S+ RA+KTSG +R  +      + DI V+HS RQ  
Sbjct: 3212 QDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPD 3271

Query: 890  WNE--CASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
             ++  C  +NG CSHLCL  P     C CP ++ L ADNRTC +  T   F  K+
Sbjct: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKT 3326



 Score =  220 bits (561), Expect = 8e-57
 Identities = 120/309 (38%), Positives = 175/309 (56%), Gaps = 6/309 (1%)

Query: 21   PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
            P L+ A+  ++R + +T+G  N T++  GL +  A+DF +    IYW D S     R   
Sbjct: 3015 PFLILADHHEIRKI-STDGS-NYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINR 3072

Query: 81   NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
                     VV     P+ LA DW+G+ LYW+D+E   IEVS L+G    +L  + L  P
Sbjct: 3073 MCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFP 3132

Query: 141  RAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWAD 200
            R ++LDP +G++YW D  E P I R GMDG+++ ++I ++I  P  LT+DY  ++LYWAD
Sbjct: 3133 RDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD 3192

Query: 201  AKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLRE 260
               N I  SN+DG++R  V    +P   ALTLFED +YWTD  T S+   +K +G     
Sbjct: 3193 E--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLS 3250

Query: 261  IHSDIFSPMDIHAFSQQRQPNAT-NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN 319
            +     +  DI  +   RQP+ + + C I+NGGCSHLCL++P K  + CACPT   L  +
Sbjct: 3251 LIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKT-HTCACPTNFYLAAD 3309

Query: 320  GKTCKDGAT 328
             +TC    T
Sbjct: 3310 NRTCLSNCT 3318



 Score =  218 bits (556), Expect = 3e-56
 Identities = 126/344 (36%), Positives = 190/344 (55%), Gaps = 15/344 (4%)

Query: 293  CSHLCLMSPVKPFYQCACPTGVKLL-ENGKTCKDGATE--LLLLARRTDLRRISLDTPDF 349
            CS  C+ +     Y+C C  G ++  +N   CK  + E   L+LA   ++R+IS D  ++
Sbjct: 2978 CSQQCINT--YGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035

Query: 350  TDIVLQLEDIRHAIAIDYDPVEGYIYWTDDE-VRAIRRSFIDGSGSQFVVTAQIAHPDGI 408
            T   L  + + + IAID+D  E +IYW D       R + +  +GS   V    A P+ +
Sbjct: 3036 T---LLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNAL 3092

Query: 409  AVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEI 468
            AVDW+ +NLYW+DT    IEV++LNG    IL+S+ L+ PR + LDP  GY+YW D  E 
Sbjct: 3093 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEY 3152

Query: 469  PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV 528
            P I R  +DG+++ V++ T +  P  L +DY   ++YW D   + IE  N DG+ R  + 
Sbjct: 3153 PHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVP 3210

Query: 529  EDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREVIIDQLPDLMGLKATNVHRV- 586
               IP +   TL  DY+YWTD + +S+ R HK S A+R  +I     +  ++  + +R  
Sbjct: 3211 NQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQP 3270

Query: 587  -IGSNPCAEENGGCSHLCLYRP-QGLRCACPIGFELISDMKTCI 628
             +  + C   NGGCSHLCL  P +   CACP  F L +D +TC+
Sbjct: 3271 DVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 3314



 Score =  180 bits (456), Expect = 1e-44
 Identities = 113/299 (37%), Positives = 157/299 (52%), Gaps = 19/299 (6%)

Query: 45  IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDW 104
           I +  L +  A+DF      IY++D +   I R + + TE  + ++   L + +G+A DW
Sbjct: 550 IPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTER-ETILKDDLDNVEGIAVDW 608

Query: 105 LGEKLYWT-DSETNRIEVSNLD--GSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGE-- 159
           +G  LYWT D     I V+ L+     RK L   E+  PR I +DP +G+MYWTDW E  
Sbjct: 609 IGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDE 668

Query: 160 ----VPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTN 215
               V +IE+A MDG +R I + S++ WPNGLTLD+    LYW DA  + I K  L+GT+
Sbjct: 669 IDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTH 728

Query: 216 RQAVVKG-SLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG--LREIHSDIFSPMDIH 272
           R+ V  G  L HPF L+   + ++WTD+   SI   +  T E   LR     +F  + I+
Sbjct: 729 RKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFG-LQIY 787

Query: 273 AFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELL 331
                R+    N C ++NGGCS LCL  P      CAC     L ENG TC     E L
Sbjct: 788 ---DPRKQQGDNMCRVNNGGCSTLCLAIPGGRV--CACADNQLLDENGTTCTFNPGEAL 841



 Score =  141 bits (355), Expect = 6e-33
 Identities = 100/404 (24%), Positives = 178/404 (44%), Gaps = 55/404 (13%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAP------------------ 932
            +EC+ +NG CS+ C  VP  G VC CP    LN DN+TC                     
Sbjct: 1174 DECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKH 1233

Query: 933  -------------------------TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
                                       F++FS +  I R+ + ++   D  L +  LRN 
Sbjct: 1234 TVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKR---DYSLLVPGLRNT 1290

Query: 968  RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRY 1027
             A+D+      LYW D  ++ I + +   S G + +   V  ++    P  L++D  +  
Sbjct: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAI--EVVVEHGLATPEGLTVDWIAGN 1348

Query: 1028 IYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAA 1087
            IYW     + I V +LDG     ++ G  + PRA+ ++P  G +++T+     P+IE A+
Sbjct: 1349 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESAS 1408

Query: 1088 LDGTEREVLF--FSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN--RIVLEDSN 1143
            + G  R+ ++      + P  L +D    ++ W D+    I S+   G N   I+     
Sbjct: 1409 MSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEY 1468

Query: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR 1203
            +  P  ++++ + +YW D +   + K +    +  + +Q   AQ  D+  +   + Q   
Sbjct: 1469 LSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQ-IYHPSRQPQA 1527

Query: 1204 QHPCAQDN--GGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE 1245
             +PCA ++  G CSH+CL+  + +  C+CP  + L  D+ +C E
Sbjct: 1528 PNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYE 1571



 Score =  127 bits (320), Expect = 7e-29
 Identities = 59/126 (46%), Positives = 73/126 (57%), Gaps = 5/126 (3%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
            DE +C +  TC P +F C     +CIP  WRCD   +C D+SDE NC    C+   F CA
Sbjct: 3467 DEANC-DKKTCGPHEFQCKNN--NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCA 3523

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
            +G C+     C+GD +C D SDE+NCE  C  DQFRC+NGQCI    KCD + DC    D
Sbjct: 3524 NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGED 3583

Query: 1357 ELDCYP 1362
            E  C P
Sbjct: 3584 EKSCEP 3589



 Score =  123 bits (309), Expect = 1e-27
 Identities = 109/375 (29%), Positives = 162/375 (43%), Gaps = 36/375 (9%)

Query: 276  QQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLAR 335
            + RQ    N C +  G CSH C+   V+  Y+C C    +   N    +    ++L +A 
Sbjct: 3838 KNRQCEDLNECLVF-GTCSHQCIN--VEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIAN 3894

Query: 336  RTDLRRISLDTP-DFTDIVLQLEDIRHAIAID----YDPVEGYIYWTDDEVRAIRRSFID 390
             TD+  +    P +++    Q+  I H   I     Y   +  I+ T      I    I 
Sbjct: 3895 DTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIH 3952

Query: 391  G----SGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDR---------------IEVTR 431
            G      +  ++  +   P  IAVDWVA N+YWTD                    I V +
Sbjct: 3953 GREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQ 4012

Query: 432  LNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGW 491
            LNG     L++    EP AI ++P  G MYWT  G+   IE AA+DG+ R +LV  +L  
Sbjct: 4013 LNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQR 4072

Query: 492  PNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK--IPHIFGFTLLGDYVYWTD 549
            P GLA+DY   +IYW D +   I  +  DG+   V V  K  + H     +  DY+Y   
Sbjct: 4073 PTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG 4132

Query: 550  WQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVIG-SNPCAEENGGCSHLCLYRP 607
              +  + RV K      E +   +    G+  ++ ++ +   NPC +    C  LCL  P
Sbjct: 4133 -PKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNP 4189

Query: 608  QGLRCACPIGFELIS 622
             G  C CP G  LI+
Sbjct: 4190 SGATCVCPEGKYLIN 4204



 Score =  115 bits (288), Expect = 3e-25
 Identities = 82/256 (32%), Positives = 119/256 (46%), Gaps = 29/256 (11%)

Query: 92   SGLLSPD-----GLACDWLGEKLYWTD---------------SETNRIEVSNLDGSLRKV 131
            SGL+ P+      +A DW+   +YWTD               S    I V  L+G     
Sbjct: 3961 SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR 4020

Query: 132  LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
            L      +P AIA++P  G MYWT  G+   IE A MDG+ R I++   +  P GL +DY
Sbjct: 4021 LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY 4080

Query: 192  EEQKLYWADAKLNFIHKSNLDGTNRQAVV--KGSLPHPFALTLFEDILYWTDWSTHSILA 249
              +++YWAD +L+ I     DG+N    V  K  L HP  + +FED +Y      + +  
Sbjct: 4081 FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFR 4139

Query: 250  CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309
              K+    +  +  +I     +    + +Q +  NPC +D   C  LCL++P      C 
Sbjct: 4140 VQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPC-LDL-ACEFLCLLNPSGA--TCV 4195

Query: 310  CPTGVKLLENGKTCKD 325
            CP G K L NG TC D
Sbjct: 4196 CPEG-KYLING-TCND 4209



 Score =  110 bits (276), Expect = 8e-24
 Identities = 56/127 (44%), Positives = 71/127 (55%), Gaps = 9/127 (7%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC----PVCSESQFQ 1294
            DE +C    +CS  QF C  G+  CIP  W+CDG  +C+   DE +C    P CS  ++ 
Sbjct: 3545 DERNC--ETSCSKDQFRCSNGQ--CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI 3600

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCAN-GQCIGKHKKCDHNVDCSD 1353
            CAS  CI  +L+CNG+ +C D SDE +C   C  DQFRC N   CI     CD   DC D
Sbjct: 3601 CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD 3660

Query: 1354 KSDELDC 1360
             SDE +C
Sbjct: 3661 GSDEENC 3667



 Score =  105 bits (261), Expect = 5e-22
 Identities = 101/367 (27%), Positives = 151/367 (41%), Gaps = 43/367 (11%)

Query: 597  GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVP---EAFLLFSRRADIRRISLETNNNN 653
            G CSH C+      +C C   F+  ++  TCI     +  L  +   DI       N + 
Sbjct: 3852 GTCSHQCINVEGSYKCVCDQNFQERNN--TCIAEGSEDQVLYIANDTDILGFIYPFNYSG 3909

Query: 654  VAIPLTGVKEAS---ALDFDVTDNRIYW-TDISLKTISRAFMNGSALEHVVEFGLDYPE- 708
                ++ ++  S    +D     + I W T  +   I    ++G   +     GL  PE 
Sbjct: 3910 DHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGRE-KRQANSGLICPEF 3968

Query: 709  ----GMAVDWLGKNLYWADTGTNR---------------IEVSKLDGQHRQVLVWKDLDS 749
                 +AVDW+  N+YW D                    I V +L+G +   L+      
Sbjct: 3969 KRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGE 4028

Query: 750  PRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWT 808
            P A+A++P  G MYWT  G    I+ AAMDG+ R  LV  N+ R  GL +DY   R+YW 
Sbjct: 4029 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWA 4088

Query: 809  DLDTNLIESSNMLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQN 865
            D + ++I S    G N  V       L HP  +  ++DYIY     +  + R  K    +
Sbjct: 4089 DFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGS 4147

Query: 866  RTIIQGHLDYVMDILVFHSSRQSGW-NECASSNGHCSHLCLAVPVGGFVCGCP-AHYSLN 923
               +  ++D    +L+ H  +Q    N C      C  LCL  P  G  C CP   Y +N
Sbjct: 4148 VEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNP-SGATCVCPEGKYLIN 4204

Query: 924  ADNRTCS 930
                TC+
Sbjct: 4205 G---TCN 4208



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 45/102 (44%), Positives = 58/102 (56%), Gaps = 5/102 (4%)

Query: 1263 CIPVAWRCDGFTECEDHSDELNCPV-----CSESQFQCASGQCIDGALRCNGDANCQDKS 1317
            C+   W CDG  +C D+SDEL CPV     C E+ F C SG+CI     C+G  +C+D  
Sbjct: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711

Query: 1318 DEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD 1359
            DE +C+  C  +QF C+  +CI KH  CD   DC D  DE D
Sbjct: 2712 DEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 56/138 (40%), Positives = 76/138 (55%), Gaps = 20/138 (14%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCPV--------C 1288
            DE+ C    +C   QF C +G   CIP  W CDG  +C D SDE  +NC          C
Sbjct: 998  DEVGCVH--SCFDNQFRCSSGR--CIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGC 1053

Query: 1289 SESQFQC-ASGQCIDGALRCNGDANCQDKSDEKNCE-VLCLID---QFRC-ANGQCIGKH 1342
            + ++FQC   G C+    RC+G+ +C+D SDEK C   + L D   +F C + G+CI K 
Sbjct: 1054 NGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKA 1113

Query: 1343 KKCDHNVDCSDKSDELDC 1360
              CD ++DC D+SDE DC
Sbjct: 1114 WVCDGDIDCEDQSDEDDC 1131



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 56/137 (40%), Positives = 74/137 (54%), Gaps = 14/137 (10%)

Query: 1239 DELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCA 1296
            DE++  E PTC P  QF C +G   CI   W CD   +C D SDE+ C   C ++QF+C+
Sbjct: 957  DEMASCEFPTCEPLTQFVCKSGR--CISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCS 1014

Query: 1297 SGQCIDGALRCNGDANCQDKSDEK--NCE-------VLCLIDQFRC-ANGQCIGKHKKCD 1346
            SG+CI G   C+GD +C D SDE   NC          C  ++F+C  +G C+    +CD
Sbjct: 1015 SGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCD 1074

Query: 1347 HNVDCSDKSDELDCYPT 1363
               DC D SDE  C  T
Sbjct: 1075 GEKDCEDGSDEKGCNGT 1091



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 34/177 (19%)

Query: 1210 DNGGCSHICLVKGDGTTRCSC----PMHLVLLQDELSCGE----------------PPTC 1249
            D  GC H C    D   RCS     P H     D   CG+                P  C
Sbjct: 998  DEVGCVHSCF---DNQFRCSSGRCIPGHWACDGDN-DCGDFSDEAQINCTKEEIHSPAGC 1053

Query: 1250 SPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC----PVCS-ESQFQC-ASGQCIDG 1303
            +  +F C   + +C+P  WRCDG  +CED SDE  C     +C  +++F C ++G+CI+ 
Sbjct: 1054 NGNEFQCHP-DGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINK 1112

Query: 1304 ALRCNGDANCQDKSDEKNCE-VLCLIDQFRCAN--GQCIGKHKKCDHNVDCSDKSDE 1357
            A  C+GD +C+D+SDE +C+  LC   +  CAN    C+   K C+   DC D SDE
Sbjct: 1113 AWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 98/372 (26%), Positives = 159/372 (42%), Gaps = 51/372 (13%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTT---FLLFSQKSAINRM 947
            NEC    G CSH C+ V  G + C C  ++     N TC A  +    L  +  + I   
Sbjct: 3846 NECLVF-GTCSHQCINVE-GSYKCVCDQNFQER--NNTCIAEGSEDQVLYIANDTDILGF 3901

Query: 948  VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
            +     S D     H   N R    D     +Y+   R  +I   Q +    F   +   
Sbjct: 3902 IYPFNYSGDHQQISHIEHNSRITGMD-----VYY--QRDMIIWSTQFNPGGIFYKRIHGR 3954

Query: 1008 PSQNLEI--------QPYDLSIDIYSRYIYWTCEA------------TNV---INVTRLD 1044
              +            +P D+++D  +  IYWT  +            T++   INV +L+
Sbjct: 3955 EKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLN 4014

Query: 1045 GRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKP 1104
            G +   +L      P A+ VNP++G MY+T + + S  IE AA+DGT R +L    L +P
Sbjct: 4015 GPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRP 4073

Query: 1105 IALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS--NILQPVGLTVFENWLYWIDK 1162
              LA+D    +++WAD +L  I S    G+N +V   S   +L P  + +FE+++Y    
Sbjct: 4074 TGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGP 4133

Query: 1163 QQQMIEKIDMTGREGRTKVQARIAQLSDI---HAVKELNLQEYRQHPCAQDNGGCSHICL 1219
            +  +  ++   G      +   I +   +   H  K+L+L     +PC   +  C  +CL
Sbjct: 4134 KNGVF-RVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDL----PNPCL--DLACEFLCL 4186

Query: 1220 VKGDGTTRCSCP 1231
            +   G T C CP
Sbjct: 4187 LNPSGAT-CVCP 4197



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 49/135 (36%), Positives = 68/135 (50%), Gaps = 10/135 (7%)

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP------VCSESQFQCASGQCI 1301
            TC+   F+C  G   C+P  W CDG  +C D SDEL+         C E+ F C +  CI
Sbjct: 2760 TCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCI 2818

Query: 1302 DGALRCNGDANCQDKSDEK-NCEV-LCLIDQFRCANGQC-IGKHKKCDHNVDCSDKSDEL 1358
                 C+ D +C D SDE   C    C  ++F CA+G+C +    +CD + DC D SDE 
Sbjct: 2819 PKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEA 2878

Query: 1359 DCYPTEEPAPQATNT 1373
               P  + A Q+ N+
Sbjct: 2879 PLNPKCKSAEQSCNS 2893



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 53/140 (37%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 1239 DELS---CGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-NCPV--CSESQ 1292
            DELS   C    TC    F C      CIP  + CD   +C D SDE   C    C   +
Sbjct: 2792 DELSTAGCAPNNTCDENAFMCHNKV--CIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEE 2849

Query: 1293 FQCASGQCI-DGALRCNGDANCQDKSDE-------KNCEVLCLIDQFRCANGQCIGKHKK 1344
            F CA G+C+ +   +C+GD +C D SDE       K+ E  C    F C NG+CI     
Sbjct: 2850 FSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGL 2909

Query: 1345 CDHNVDCSDKSDELDCYPTE 1364
            CD+  DC D SDE +C+  E
Sbjct: 2910 CDNKDDCGDGSDERNCHINE 2929



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 65/229 (28%), Positives = 82/229 (35%), Gaps = 68/229 (29%)

Query: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID 1262
            R++ CA D  GC    L K +G   C+         DE+ C     C   QF C   +  
Sbjct: 3597 REYICASD--GCISASL-KCNGEYDCADG------SDEMDC--VTECKEDQFRC-KNKAH 3644

Query: 1263 CIPVAWRCDGFTECEDHSDELNCP----VCSESQFQCASGQC------------------ 1300
            CIP+ W CDG  +C D SDE NC     +C   +F C +  C                  
Sbjct: 3645 CIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSD 3704

Query: 1301 -------------------------IDGALRCNGDANCQDKSDEKNCEVL-------CLI 1328
                                     +     CNG   C D SDE +C          C  
Sbjct: 3705 EAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKK 3764

Query: 1329 DQFRCANGQCIGKHKKCDHNVDCSDKSDELDC--YPTEEPAPQATNTVG 1375
            D+F C+N +CI    +CD   DC D SDE  C   PTE       N  G
Sbjct: 3765 DEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCG 3813



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 122/502 (24%), Positives = 183/502 (36%), Gaps = 106/502 (21%)

Query: 891  NECASSN-GHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC--------SAPTTFLLFSQK 941
            NEC S     CS  C  +PV  + C C   + L  D +TC          P +    +  
Sbjct: 2928 NECLSKKVSGCSQDCQDLPVS-YKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTY 2986

Query: 942  SAINRMVIDEQQ-SPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGS--- 997
                 +  D  +  PD      SL           D++ + I +  + IRK   DGS   
Sbjct: 2987 GTYKCLCTDGYEIQPDNPNGCKSLS----------DEEPFLILADHHEIRKISTDGSNYT 3036

Query: 998  ---QGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEAT---NVINVTRLDGRSVGVV 1051
               QG   V++             +  D    +IYW   +    + IN   L+G  + VV
Sbjct: 3037 LLKQGLNNVIA-------------IDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVV 3083

Query: 1052 LKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDS 1111
                   P A+ V+     +Y+++ ++R   IE + L+G    +L    L  P  L+LD 
Sbjct: 3084 HNTAV--PNALAVDWIGKNLYWSDTEKRI--IEVSKLNGLYPTILVSKRLKFPRDLSLDP 3139

Query: 1112 RLGKLFWADS-DLRRIESSDLSGANRIVLEDSNILQPVGLTV--FENWLYWIDKQQQMIE 1168
            + G L+W D  +   I    + G N+ V+ ++ I +P+ LT+      LYW D+    IE
Sbjct: 3140 QAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IE 3197

Query: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNL-QEYRQHPCAQDNGGCSHICLVKGDGTTR 1227
              +M G   R KV  +     DI  V  L L ++Y                +   DG T+
Sbjct: 3198 FSNMDGSH-RHKVPNQ-----DIPGVIALTLFEDY----------------IYWTDGKTK 3235

Query: 1228 CSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV 1287
                 H     D LS                     +  +W     T+ + +      P 
Sbjct: 3236 SLSRAHKTSGADRLS---------------------LIYSWHA--ITDIQVYHSYRQ-PD 3271

Query: 1288 CSESQFQCASGQCIDGAL-------RCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIG 1340
             S+      +G C    L        C    N    +D + C   C   QFRC   +CI 
Sbjct: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIP 3331

Query: 1341 KHKKCDHNVDCSDKSDELDCYP 1362
               KCD   DC D SDE D  P
Sbjct: 3332 FWWKCDTVDDCGDGSDEPDDCP 3353



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 50/156 (32%), Positives = 68/156 (43%), Gaps = 26/156 (16%)

Query: 1190 DIHAVKELNLQEYRQHP---CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC-GE 1245
            +IH+    N  E++ HP   C  D   C        DG   C          DE  C G 
Sbjct: 1046 EIHSPAGCNGNEFQCHPDGNCVPDLWRC--------DGEKDCEDG------SDEKGCNGT 1091

Query: 1246 PPTCSPQ-QFTCF-TGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCASGQ-- 1299
               C  + +F+C+ TG   CI  AW CDG  +CED SDE +C   +C   +  CA+    
Sbjct: 1092 IRLCDHKTKFSCWSTGR--CINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSV 1149

Query: 1300 CIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCAN 1335
            C+     CNG  +C D SDE      C ++   C+N
Sbjct: 1150 CLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSN 1185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 11/95 (11%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCP-----VCSESQFQC-ASGQC 1300
            C P +F C    + C+  +W CDG  +C D SDE    CP      C  +   C  + +C
Sbjct: 32   CDPGEFLCHD-HVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90

Query: 1301 IDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRC 1333
            +  +  CNG  +C D  DE  +C E+L    Q  C
Sbjct: 91   VHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC 125



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 2/95 (2%)

Query: 34   VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92
            V   NG     ++     +  A+      G++YW+ V + + I+    + T   + +V  
Sbjct: 4010 VGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLR-RILVQK 4068

Query: 93   GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
             L  P GLA D+  E++YW D E + I     DGS
Sbjct: 4069 NLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 4103



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 17/79 (21%)

Query: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
            C+ +NGGCS+ C V       CSCP  L L +D  +C     CS          + C  V
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCS--------NHLKCSQV 1227

Query: 1267 AWRCDGFTECEDHSDELNC 1285
                     CE H   + C
Sbjct: 1228 ---------CEQHKHTVKC 1237



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 31/131 (23%), Positives = 53/131 (40%), Gaps = 23/131 (17%)

Query: 1202 YRQHPCAQDNGGCSHICLVK-----------GDGTTRCSC---PMHLVLLQDELSCGEPP 1247
            Y+  PC +D   CS+   +            GDG+    C   P       +   CG+  
Sbjct: 3757 YKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDA 3816

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRC 1307
             C+  + + F     C P   R     +CED ++ L    CS    QC +   ++G+ +C
Sbjct: 3817 YCNQIKTSVF---CRCKPGFQRNMKNRQCEDLNECLVFGTCSH---QCIN---VEGSYKC 3867

Query: 1308 NGDANCQDKSD 1318
              D N Q++++
Sbjct: 3868 VCDQNFQERNN 3878


>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
          Length = 4655

 Score =  686 bits (1771), Expect = 0.0
 Identities = 452/1401 (32%), Positives = 727/1401 (51%), Gaps = 82/1401 (5%)

Query: 22   LLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFN 81
            LLL A++  +     T+   N   +V       AVDF    G I+WSD ++        N
Sbjct: 1437 LLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQN 1496

Query: 82   KTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141
             T+  + V  S ++  + +A DW+G  LYWTD     IEVS +DGS R VL  + L  PR
Sbjct: 1497 GTDR-RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPR 1555

Query: 142  AIALDP--SSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWA 199
             +ALDP  +   ++W+DWG  P+IERA MDGS R +I+  +I+WP GLT+DY  + LY+ 
Sbjct: 1556 GLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFM 1615

Query: 200  DAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWSTHSILACNKYTGEG 257
            D+ L+++   + +G +R+ V+   L   HP+ALTLFED +YWTD +T  ++  NK+ G  
Sbjct: 1616 DSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGN 1675

Query: 258  LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKP-FYQCACPTGVKL 316
               +  +I  P+ I A    +QPN+ NPC      CSHLCL+S   P FY C CP+G  L
Sbjct: 1676 QSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSL 1733

Query: 317  LENGKTCKDGATELLLLARRTDLRRISLDTP-DFTDIVLQLEDIRHAIAIDYDPVEGYIY 375
              +   C       L+  R+  +  ISL+      D ++ +  I++ + +++D  E YIY
Sbjct: 1734 SPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIY 1793

Query: 376  WTDDEVRAIRRSFIDGSGSQFVVTAQIAHPD-GIAVDWVARNLYWTDTGTDRIEVTRLNG 434
            W ++    I R   DG+      +  +  P   +A+DW++RNLY T+  T  IEV  L+G
Sbjct: 1794 WVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHG 1852

Query: 435  TM--RKILISED-----LEEPRAIVLDPMVGYMYWTDWGE---IP-KIERAALDGSDRVV 483
             +  RK LI+ D     +  P  I +DP  G +YW+D G    +P KI  A +DG+    
Sbjct: 1853 DIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKT 1912

Query: 484  LVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD 543
            L   +L     + LD +E K+YW       IE  N DGT R +LV  ++ H +G  +   
Sbjct: 1913 LFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH-QLSHPWGIAVHDS 1971

Query: 544  YVYWTDWQRRSIERVHKRSAEREVII-DQLPDLMGLKATNVHRVI-GSNPCAEENGGCSH 601
            ++Y+TD Q   IERV K +   ++++ D +P+L GL+  +       SN C+     C  
Sbjct: 1972 FLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQ 2031

Query: 602  LCLYRPQGL-RCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLE-TNNNNVAIPLT 659
            +CL  P GL  CAC  GF+L  D ++C    +F++ S  + IR  SLE ++++   +P+ 
Sbjct: 2032 ICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVA 2091

Query: 660  GV-KEASALDFDVTDNRIYWTDISL-----KTISRAFMNGSALEHVVEFGL--DYPEGMA 711
            G  + A  +D DV+   IYW D S        I R   +GS+L ++V  G+  +   G+A
Sbjct: 2092 GQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIA 2151

Query: 712  VDWLGKNLYWADTGTNR--IEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGG 769
            VDW+  NLY+ +   +   IEV +++  +R+VL+   +D PR + +DP   +++W ++G 
Sbjct: 2152 VDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQ 2211

Query: 770  KPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI 828
            +PKI+R+ +D + RT LV   +    GL +D +   +YW D   ++I    + G N EVI
Sbjct: 2212 RPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVI 2271

Query: 829  --ADDLPHPFGLTQYQDYIYWTDWSRRSIERANK--TSGQNRTIIQGHLDYVMDILVF-- 882
                  P P+G+T +++ I W D + + I +A+K   + +  T+I+ +++++ D+ +F  
Sbjct: 2272 RYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDK 2331

Query: 883  ----HSSRQSGWNECASSNGHCSHLCLAVP-VGGFVCGCPAHYSLNADNRTCSAPT-TFL 936
                 S  +   N C  +NG CSHLC A+P +    C C A  +L +D + C+  T  FL
Sbjct: 2332 QVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDC-AFGTLQSDGKNCAISTENFL 2390

Query: 937  LFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQ--- 993
            +F+  +++  + +D +        I+  R V ++DYD +  ++Y+  +  + + +     
Sbjct: 2391 IFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYAT 2450

Query: 994  -EDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVL 1052
               G    TV+ S + + +       ++ D  +R IY++     +IN    DG +  V+ 
Sbjct: 2451 LSSGIHTPTVIASGIGTAD------GIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIA 2504

Query: 1053 KGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSR 1112
            +    +PRA+V++P +GY+Y+ +    + KIERA L G  R  +  S L  P  L LD  
Sbjct: 2505 R--VPKPRAIVLDPCQGYLYWADWDTHA-KIERATLGGNFRVPIVNSSLVMPSGLTLDYE 2561

Query: 1113 LGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM 1172
               L+W D+ L+RIE S L+G +R V+ ++ +    GLT++  ++YW D   Q I + + 
Sbjct: 2562 EDLLYWVDASLQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANK 2620

Query: 1173 TGREGRTKVQAR-IAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCP 1231
                G+  +    ++Q   I+ V + N ++   +PC Q NGGCSHIC   G     C CP
Sbjct: 2621 YDGSGQIAMTTNLLSQPRGINTVVK-NQKQQCNNPCEQFNGGCSHIC-APGPNGAECQCP 2678

Query: 1232 ----MHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN--C 1285
                 +L   +          C    FTC  G   CI   W+CD   +C D SDE+   C
Sbjct: 2679 HEGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDNDNDCGDGSDEMESVC 2736

Query: 1286 PV--CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGK 1341
             +  CS + F CA+G+C+  + RC+   +C D SDE  C         +F C N +CI +
Sbjct: 2737 ALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPR 2796

Query: 1342 HKKCDHNVDCSDK--SDELDC 1360
               C+   +C D   SDE +C
Sbjct: 2797 EFICNGVDNCHDNNTSDEKNC 2817



 Score =  488 bits (1257), Expect = e-137
 Identities = 316/1029 (30%), Positives = 521/1029 (50%), Gaps = 91/1029 (8%)

Query: 284  NPCGIDNGGCSHLCLMSP--------------------------------------VKPF 305
            N C   NGGC+H C+  P                                      ++  
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGS 1410

Query: 306  YQCACPTGVKLLENGKTCKDGATE--LLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAI 363
            ++C+C TG  L  +G+TCK  A+E  LLL+A +  +   S+ T    +I   +E+  + +
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSV-TSQVHNIYSLVENGSYIV 1469

Query: 364  AIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTG 423
            A+D+D + G I+W+D        +F +G+  + V  + I   + IA+DWV RNLYWTD  
Sbjct: 1470 AVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYA 1529

Query: 424  TDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVG--YMYWTDWGEIPKIERAALDGSDR 481
             + IEV++++G+ R +LIS++L  PR + LDP +    ++W+DWG  P+IERA++DGS R
Sbjct: 1530 LETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMR 1589

Query: 482  VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDK--IPHIFGFT 539
             V+V   + WP GL +DY    +Y+ D+  D ++  + +G  RR ++     I H +  T
Sbjct: 1590 TVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALT 1649

Query: 540  LLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVIGS-NPCAEENG 597
            L  D VYWTD   R + R +K     + V++  +   +G+ A +  +   S NPCA    
Sbjct: 1650 LFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR- 1708

Query: 598  GCSHLCLYRPQG---LRCACPIGFELISDMKTCI-VPEAFLLFSRRADIRRISL--ETNN 651
             CSHLCL   QG     C CP G+ L  D+  C+   + FL+  R+  I  ISL  E  +
Sbjct: 1709 -CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKS 1767

Query: 652  NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPE-GM 710
            N+  +P+ G++    ++FD  +  IYW + +   I R   +G+         +  P   +
Sbjct: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNL 1826

Query: 711  AVDWLGKNLYWADTGTNRIEVSKLDG--QHRQVLVWKD-----LDSPRALALDPAEGFMY 763
            A+DW+ +NLY  +  T  IEV  L G  ++R+ L+  D     +  P  + +DPA G +Y
Sbjct: 1827 ALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLY 1886

Query: 764  WTEWG---GKP-KIDRAAMDG-SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESS 818
            W++ G   G P KI  A MDG S +T    N+     +T+D  +++LYW      +IE  
Sbjct: 1887 WSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERG 1946

Query: 819  NMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMD 878
            N+ G +R ++   L HP+G+  +  ++Y+TD     IER +K +G N+ +++ ++  +  
Sbjct: 1947 NVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRG 2006

Query: 879  ILVFH-SSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLL 937
            + V+H  +     N C+++   C  +CL VP G F C C   + LN DNR+CS   +F++
Sbjct: 2007 LQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIV 2066

Query: 938  FSQKSAINRMVIDEQQSPDIILPIHSL-RNVRAIDYDPLDKQLYWID-----SRQNMIRK 991
             S  SAI    ++     + ++P+    RN   +D D     +YW D     +  N IR+
Sbjct: 2067 VSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRR 2126

Query: 992  AQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWT--CEATNVINVTRLDGRSVG 1049
             + DGS    +V   +    +      +++D  +  +Y+T    +  +I V R++     
Sbjct: 2127 IKPDGSSLMNIVTHGIGENGVR----GIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRR 2182

Query: 1050 VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
            V+LK   D PR +VV+P+  Y+++ +  +R PKIER+ LD T R VL   G+  P  LA+
Sbjct: 2183 VLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGLAV 2241

Query: 1110 DSRLGKLFWADSDLRRIESSDLSGAN-RIVLEDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
            D   G ++W D  L  I    ++G N  ++   S    P G+TVFEN + W+D+  + I 
Sbjct: 2242 DRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIF 2301

Query: 1169 KI--DMTGREGRTKVQARIAQLSDI----HAVKELNLQEYRQHPCAQDNGGCSHICL-VK 1221
            +   +    E  T ++  I  L D+      V+  +  E   +PC ++NGGCSH+C  + 
Sbjct: 2302 QASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALP 2361

Query: 1222 GDGTTRCSC 1230
            G  T +C C
Sbjct: 2362 GLHTPKCDC 2370



 Score =  383 bits (983), Expect = e-106
 Identities = 210/623 (33%), Positives = 351/623 (56%), Gaps = 23/623 (3%)

Query: 23   LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL--IYWSDVSEEAIKRTEF 80
            ++++N RDL L+   +G+ +  I+V       AV   F + L  ++W+D  +  +   + 
Sbjct: 396  IIFSNGRDL-LIGDIHGR-SFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDI 453

Query: 81   NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
            N   ++Q V+   + +P+ LA DW+  K+Y  +++ NRI++ NLDGS R  L  + L  P
Sbjct: 454  NGL-NIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHP 512

Query: 141  RAIALDPSSGFMYWTDWGEV---PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLY 197
            R IA+DP+ G+++++DW  +   PK+ERA MDGS+R  ++ +++ WP G+TLD   +++Y
Sbjct: 513  RGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVY 572

Query: 198  WADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTG 255
            W D++ ++I     DG  R+ VV G   +PHPF ++LFE  +++TDW+  ++L  NK+T 
Sbjct: 573  WVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632

Query: 256  EGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPF----YQCACP 311
               +  +     P  +  +   RQP ATNPC  +NGGC  +C++S         ++C C 
Sbjct: 633  TNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCT 692

Query: 312  TGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLE-DIRHAIAIDYDPV 370
             G +L  + + C       L+ + +  +R I        D+++ +  +    + ID+D  
Sbjct: 693  FGFQLDTDERHCI-AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQ 751

Query: 371  EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVT 430
            +  I+++D     I +  IDG+G + +   ++ + + +A DW+++NLYWTD+    I V 
Sbjct: 752  DSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVM 811

Query: 431  RLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLG 490
            RL    R+ ++ + L  PR++V+ P  GY+++TDW    KI RA  DGS  + ++NT+LG
Sbjct: 812  RLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870

Query: 491  WPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTLLGDYVYWTD 549
            WPNGLA+D+   ++YW DA  DKIE    DG  RR L   +++ H FG  + G+++++TD
Sbjct: 871  WPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTD 930

Query: 550  WQRRSIERVHKR-SAEREVIIDQLPDLMGLKATNVHRVIGSNPC---AEENGGCSHLCLY 605
            W+  +I RV K    E  VI   +  ++ LK+ +V+   GSN C      NG CSH C  
Sbjct: 931  WRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFP 990

Query: 606  RPQGLR-CACPIGFELISDMKTC 627
             P   R C CP G  L S+  TC
Sbjct: 991  VPNFQRVCGCPYGMRLASNHLTC 1013



 Score =  381 bits (978), Expect = e-105
 Identities = 254/822 (30%), Positives = 404/822 (49%), Gaps = 68/822 (8%)

Query: 597  GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAF----LLFSRRADIR--------- 643
            G C   C  RP    C C  G+ ++   + C   ++F    ++FS   D+          
Sbjct: 356  GICDQKCESRPGRHLCHCEEGY-ILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSF 414

Query: 644  RISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFG 703
            RI +E+ N  VA+ +          F     R++WTD     +    +NG  ++ V+   
Sbjct: 415  RILVESQNRGVAVGVA---------FHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVS 465

Query: 704  LDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMY 763
            ++ PE +AVDW+   +Y  +T  NRI++  LDG +R  L+ ++L  PR +A+DP  G+++
Sbjct: 466  VETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLF 525

Query: 764  WTEW---GGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSN 819
            +++W    G+PK++RA MDGS R  LV   +G   G+T+D   +R+YW D   + IE+  
Sbjct: 526  FSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVT 585

Query: 820  MLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYV 876
              G+ R+ +      +PHPFG++ ++  +++TDW++ ++ +ANK +  N  +        
Sbjct: 586  YDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRP 645

Query: 877  MDILVFHSSRQS-GWNECASSNGHCSHLCLAVPVG-----GFVCGCPAHYSLNADNRTCS 930
              + V+HS RQ    N C  +NG C  +C+          GF C C   + L+ D R C 
Sbjct: 646  YGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705

Query: 931  APTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRN-VRAIDYDPLDKQLYWIDSRQNMI 989
            A   FL+FS + AI  +        D+++P+    +    ID+D  D  +++ D  ++MI
Sbjct: 706  AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765

Query: 990  RKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG 1049
             K + DG+    +  + V  +N+E     L+ D  S+ +YWT      I+V RL  ++  
Sbjct: 766  FKQKIDGTGREILAANRV--ENVE----SLAFDWISKNLYWTDSHYKSISVMRLADKTRR 819

Query: 1050 VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAL 1109
             V++   + PR+VVV+P  GY++FT+   R  KI RA  DG+    +  + L  P  LA+
Sbjct: 820  TVVQ-YLNNPRSVVVHPFAGYLFFTD-WFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAI 877

Query: 1110 DSRLGKLFWADSDLRRIESSDLSGANRIVL-EDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
            D    +L+W D+   +IE S   G +R  L     +  P GL +F   L++ D +   I 
Sbjct: 878  DWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAII 937

Query: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQ---DNGGCSHICLVKGDGT 1225
            ++        T +++ IA +  + +  ++N+Q    + C Q    NG CSH C    +  
Sbjct: 938  RVRKADGGEMTVIRSGIAYILHLKSY-DVNIQT-GSNACNQPTHPNGDCSHFCFPVPNFQ 995

Query: 1226 TRCSCPMHLVLLQDELSC-----GEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECED 1278
              C CP  + L  + L+C      EPPT  C    F C  G   C+P  + CDG  +C D
Sbjct: 996  RVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGR--CVPNYYLCDGVDDCHD 1053

Query: 1279 HSDELNC----PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC----EVLCLIDQ 1330
            +SDE  C      CS S F C  G+CI    RC+   +C D SDE NC       CL  Q
Sbjct: 1054 NSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQ 1113

Query: 1331 FRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATN 1372
            + C N QCI K+  CD + DC D SDE +C  TE   P   N
Sbjct: 1114 YTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFN 1155



 Score =  327 bits (838), Expect = 6e-89
 Identities = 227/735 (30%), Positives = 365/735 (49%), Gaps = 90/735 (12%)

Query: 581  TNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCI-VPEAFLL---- 635
            T+   +   N C++ NGGC+H C+  P G +C CP+GF L +D KTC  + E  +L    
Sbjct: 1342 TDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCS 1401

Query: 636  ---FSRRADIR------------------------RISLETNNNNVAIPLTG-------- 660
               ++ R   R                         + + + N  +A  +T         
Sbjct: 1402 QHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSL 1461

Query: 661  VKEAS---ALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGK 717
            V+  S   A+DFD    RI+W+D +      AF NG+    V +  +   E +A+DW+G+
Sbjct: 1462 VENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGR 1521

Query: 718  NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPA--EGFMYWTEWGGKPKIDR 775
            NLYW D     IEVSK+DG HR VL+ K+L +PR LALDP   E  ++W++WG  P+I+R
Sbjct: 1522 NLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIER 1581

Query: 776  AAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLN-REVIADDL- 832
            A+MDGS RT +V + +    GLTIDY  R LY+ D   + ++  +  G + R+VIA DL 
Sbjct: 1582 ASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLI 1641

Query: 833  -PHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGW 890
              HP+ LT ++D +YWTD + R + RANK  G N++++  ++ + + I+  H S+Q +  
Sbjct: 1642 IRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSV 1701

Query: 891  NECASSNGHCSHLCLAVPVGG--FVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947
            N CA S   CSHLCL    G   + C CP+ +SL+ D   C      FL+  ++  I  +
Sbjct: 1702 NPCAFS--RCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGI 1759

Query: 948  VID-EQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQG--FTVVV 1004
             ++ E +S D ++PI  ++N   +++D  ++ +YW+++    I + + DG+    F  + 
Sbjct: 1760 SLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASIS 1818

Query: 1005 SSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRL-------------DGRSVGVV 1051
               PS N       L++D  SR +Y T   T  I V  L             DG ++GV 
Sbjct: 1819 MVGPSMN-------LALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVG 1871

Query: 1052 LKGEQDRPRAVVVNPEKGYMYFTNLQERS---PKIERAALDGTEREVLFFSGLSKPIALA 1108
                   P  + V+P +G +Y+++    S    KI  A +DGT  + LF   L     + 
Sbjct: 1872 F------PIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVT 1925

Query: 1109 LDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
            LD    KL+WA +    IE  ++ G +R++L    +  P G+ V +++LY+ D+Q ++IE
Sbjct: 1926 LDIEEQKLYWAVTGRGVIERGNVDGTDRMILV-HQLSHPWGIAVHDSFLYYTDEQYEVIE 1984

Query: 1169 KIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRC 1228
            ++D      +  ++  +  L  +      N  E   + C+ +   C  ICL    G   C
Sbjct: 1985 RVDKATGANKIVLRDNVPNLRGLQVYHRRNAAE-SSNGCSNNMNACQQICLPVPGGLFSC 2043

Query: 1229 SCPMHLVLLQDELSC 1243
            +C     L  D  SC
Sbjct: 2044 ACATGFKLNPDNRSC 2058



 Score =  256 bits (655), Expect = 1e-67
 Identities = 122/306 (39%), Positives = 184/306 (60%), Gaps = 11/306 (3%)

Query: 21   PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
            P L+++NR  LR  + T      ++++ GL++  A+DF      +YW D   + I+R   
Sbjct: 3199 PYLIFSNRYYLR--NLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL 3256

Query: 81   NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELD-- 138
            NKT   + ++   L + + LA DW+  KLYW D+  + + VS+L+G  R++L    +D  
Sbjct: 3257 NKTNK-ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDAN 3315

Query: 139  ------QPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYE 192
                   PR +AL P  G++YW DWG    I R GMDG+++ +II++++ WPNG+T+DY 
Sbjct: 3316 NTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYT 3375

Query: 193  EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNK 252
               LYWADA L +I  S+L+G +R  V  G+LPHPFA+T+FED +YWTDW+T ++   NK
Sbjct: 3376 NDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNK 3435

Query: 253  YTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPT 312
            Y G   + + +    P DIH +   RQP  +NPCG +NGGCSHLCL+ P    + C CP 
Sbjct: 3436 YDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPD 3495

Query: 313  GVKLLE 318
              + L+
Sbjct: 3496 DFRTLQ 3501



 Score =  248 bits (633), Expect = 3e-65
 Identities = 160/486 (32%), Positives = 241/486 (49%), Gaps = 33/486 (6%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTT---FLLFSQKSAINRM 947
            +EC      CS  C  V +G ++C C   Y    D +TC   +    +L+FS +  +  +
Sbjct: 3154 DECTEMPFVCSQKCENV-IGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNL 3212

Query: 948  VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV 1007
             ID        L +  L NV A+D+D ++K+LYWID+++ +I +   + +   T++   +
Sbjct: 3213 TIDGYFYS---LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRL 3269

Query: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQD--------RP 1059
            P+         L++D  SR +YW     + + V+ L+G    ++ +   D         P
Sbjct: 3270 PAAE------SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNP 3323

Query: 1060 RAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWA 1119
            R + ++P+ GY+Y+ +   R+  I R  +DGT + V+  + L  P  + +D     L+WA
Sbjct: 3324 RGLALHPQYGYLYWADWGHRA-YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWA 3382

Query: 1120 DSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRT 1179
            D+ L  IE SDL G +R  + D  +  P  +T+FE+ +YW D   + +EK +      R 
Sbjct: 3383 DAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442

Query: 1180 KVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVK--GDGTTRCSCPMHLVLL 1237
             +     +  DIH       Q    +PC  +NGGCSH+CL+K  G G T C CP     L
Sbjct: 3443 TLVNTTHRPFDIHVYHPYR-QPIVSNPCGTNNGGCSHLCLIKPGGKGFT-CECPDDFRTL 3500

Query: 1238 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN-CP--VCSESQFQ 1294
            Q   S    P CS  QF C   E  CIP+ W+CDG  +C D SDEL  CP   C   QFQ
Sbjct: 3501 QLSGSTYCMPMCSSTQFLCANNE-KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQ 3559

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKN--CE-VLCLIDQFRCANGQCIGKHKKCDHNVDC 1351
            C+ G C      CN   NC D SDE    CE   C  ++++CAN +CI +  +CD   DC
Sbjct: 3560 CSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619

Query: 1352 SDKSDE 1357
             D SDE
Sbjct: 3620 EDNSDE 3625



 Score =  229 bits (583), Expect = 2e-59
 Identities = 138/419 (32%), Positives = 204/419 (48%), Gaps = 64/419 (15%)

Query: 588  GSNPCAEEN-GGCSHLCLYRPQGLRCACPIGFELISDMKTCI-------VP--------- 630
            G N C + +  GC H C        C+C  G++L+SD +TC+       +P         
Sbjct: 3110 GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCEN 3169

Query: 631  ----------------------------EAFLLFSRRADIRRISLETNNNNVAIPLTGVK 662
                                        E +L+FS R  +R ++++      ++ L G+ 
Sbjct: 3170 VIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID--GYFYSLILEGLD 3227

Query: 663  EASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
               ALDFD  + R+YW D   + I R F+N +  E ++   L   E +AVDW+ + LYW 
Sbjct: 3228 NVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWL 3287

Query: 723  DTGTNRIEVSKLDGQHRQVLVWKDL--------DSPRALALDPAEGFMYWTEWGGKPKID 774
            D   + + VS L+G HR++L    +        D+PR LAL P  G++YW +WG +  I 
Sbjct: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347

Query: 775  RAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD-L 832
            R  MDG+ ++ ++   +   NG+TIDY    LYW D     IE S++ G +R  + D  L
Sbjct: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGAL 3407

Query: 833  PHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQS-GWN 891
            PHPF +T ++D IYWTDW+ R++E+ NK  G NR  +        DI V+H  RQ    N
Sbjct: 3408 PHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSN 3467

Query: 892  ECASSNGHCSHLCLAVPVG-GFVCGCPAHY-SLNADNRTCSAP----TTFLLFSQKSAI 944
             C ++NG CSHLCL  P G GF C CP  + +L     T   P    T FL  + +  I
Sbjct: 3468 PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCI 3526



 Score =  224 bits (572), Expect = 4e-58
 Identities = 115/343 (33%), Positives = 184/343 (53%), Gaps = 19/343 (5%)

Query: 293  CSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGAT--ELLLLARRTDLRRISLDTPDFT 350
            CS  C    V   Y C C  G     +GKTC+  +     L+ + R  LR +++D   ++
Sbjct: 3163 CSQKC--ENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYS 3220

Query: 351  DIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
               L LE + + +A+D+D VE  +YW D + + I R F++ +  + ++  ++   + +AV
Sbjct: 3221 ---LILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAV 3277

Query: 411  DWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLE--------EPRAIVLDPMVGYMYW 462
            DWV+R LYW D   D + V+ LNG  R++L    ++         PR + L P  GY+YW
Sbjct: 3278 DWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYW 3337

Query: 463  TDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGT 522
             DWG    I R  +DG+++ V+++T L WPNG+ +DY    +YW DA    IE  + +G 
Sbjct: 3338 ADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGH 3397

Query: 523  GRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKAT 581
             R  + +  +PH F  T+  D +YWTDW  R++E+ +K   + R+ +++       +   
Sbjct: 3398 HRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVY 3457

Query: 582  NVHR-VIGSNPCAEENGGCSHLCLYRP--QGLRCACPIGFELI 621
            + +R  I SNPC   NGGCSHLCL +P  +G  C CP  F  +
Sbjct: 3458 HPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500



 Score =  207 bits (528), Expect = 5e-53
 Identities = 131/358 (36%), Positives = 195/358 (54%), Gaps = 29/358 (8%)

Query: 291  GGCSHLCLMSPVKPFYQCACPTGVKLLEN--GKTCK-DGATELLLLARRTDLRRISLDTP 347
            G C   C  +  K  Y+C C  G   + +  GK C  +G++ LLLL     +R+ +L + 
Sbjct: 4015 GTCPQHCRNT--KGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSE 4072

Query: 348  DFTDIVLQLEDIRHAIAIDYDPVE---GYIYWT----DDEVRAIRRSFIDG--SGSQFVV 398
             F++  LQ E+   A+  D+DP +     +Y+T         AI+R++I    SG   +V
Sbjct: 4073 RFSEY-LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLV 4131

Query: 399  TA------QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIV 452
                     +  PDGIAVDWV R++YW+D    RIEV +L+G  RK LIS DL++P AI 
Sbjct: 4132 QEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIA 4191

Query: 453  LDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY-DEGKIYWGDAKT 511
            ++P +G M+WTDWG+ PKIE A ++G DR +LV   LGWP GL++DY +  +IYW D K 
Sbjct: 4192 VNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKE 4251

Query: 512  DKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIID 570
            D IE +  DGT RRV+ ++ + + +   +  D +YW   ++  + + +K    ++E  + 
Sbjct: 4252 DVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310

Query: 571  QLPDLMGLKATNVHRVIGSNP--CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKT 626
              P L  ++  +  R   S P  C +    CSHLCL RP G  CACP G   I    T
Sbjct: 4311 VNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGYSCACPQGSSFIEGSTT 4365



 Score =  185 bits (469), Expect = 4e-46
 Identities = 106/268 (39%), Positives = 152/268 (56%), Gaps = 19/268 (7%)

Query: 74   AIKRTEFNKTESVQNVVVSGL-------LSPDGLACDWLGEKLYWTDSETNRIEVSNLDG 126
            AIKR      ES +N +V  +       + PDG+A DW+G  +YW+D +  RIEV+ LDG
Sbjct: 4114 AIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDG 4173

Query: 127  SLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNG 186
              RK L   +LDQP AIA++P  G M+WTDWG+ PKIE A M+G  R I++  ++ WP G
Sbjct: 4174 RYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTG 4233

Query: 187  LTLDY-EEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTH 245
            L++DY    ++YW+D K + I     DGT+R+ + K ++ +P++L +FED LYW      
Sbjct: 4234 LSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEKG 4292

Query: 246  SILACNKYTGEGLREIHSDIFSP--MDIHAFSQQR-QPNATNPCGIDNGGCSHLCLMSPV 302
             +   NK+ G+G +E  + + +P    +  F Q R   +  N C      CSHLCL+ P 
Sbjct: 4293 EVWKQNKF-GQGKKE-KTLVVNPWLTQVRIFHQLRYNKSVPNLC---KQICSHLCLLRP- 4346

Query: 303  KPFYQCACPTGVKLLENGKTCKDGATEL 330
               Y CACP G   +E   T  D A EL
Sbjct: 4347 -GGYSCACPQGSSFIEGSTTECDAAIEL 4373



 Score =  176 bits (446), Expect = 2e-43
 Identities = 117/353 (33%), Positives = 183/353 (51%), Gaps = 32/353 (9%)

Query: 590  NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM--KTCIVPEA--FLLFSRRADIRRI 645
            N C E+ G C   C        C C  GF  +SD   K C    +   LL      IR+ 
Sbjct: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067

Query: 646  SLETNNNNVAIPLTGVKEASALDFDVTD---NRIYWT----DISLKTISRAFMNG----- 693
            +L +   +  +      +A   D+D  D   + +Y+T          I RA++       
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127

Query: 694  SALEHVVEFGLDY---PEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSP 750
            + L   V+  L Y   P+G+AVDW+G+++YW+D    RIEV+KLDG++R+ L+  DLD P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187

Query: 751  RALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR-RLYWT 808
             A+A++P  G M+WT+WG +PKI+ A M+G +R  LV  ++G   GL+IDY    R+YW+
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247

Query: 809  DLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANK--TSGQNR 866
            D   ++IE+    G +R VIA +  +P+ L  ++D +YW    +  + + NK     + +
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307

Query: 867  TIIQGHLDYVMDILVFHSSR--QSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
            T++     ++  + +FH  R  +S  N C      CSHLCL  P GG+ C CP
Sbjct: 4308 TLVVN--PWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRP-GGYSCACP 4354



 Score =  162 bits (409), Expect = 3e-39
 Identities = 99/312 (31%), Positives = 163/312 (52%), Gaps = 10/312 (3%)

Query: 23   LLYANRRDLRLVDAT-NGKENATIVVGGLEDA-AAVDFVFSHGLIYWSDVSEEAIKRTEF 80
            L+++++  +R +  T + +E+  + V G       +DF      I++SD+S+  I + + 
Sbjct: 711  LIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKI 770

Query: 81   NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQP 140
            + T   + +  + + + + LA DW+ + LYWTDS    I V  L    R+ +  Q L+ P
Sbjct: 771  DGTGR-EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNP 828

Query: 141  RAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWAD 200
            R++ + P +G++++TDW    KI RA  DGS    +IN+ + WPNGL +D+   +LYW D
Sbjct: 829  RSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVD 888

Query: 201  AKLNFIHKSNLDGTNRQAVVK-GSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLR 259
            A  + I  S  DG +R+ +     + HPF L +F + L++TDW   +I+   K  G  + 
Sbjct: 889  AYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMT 948

Query: 260  EIHSDIFSPMDIHAFSQQRQP--NATNPCGIDNGGCSHLCLMSPVKPFYQ-CACPTGVKL 316
             I S I   + + ++    Q   NA N     NG CSH C   PV  F + C CP G++L
Sbjct: 949  VIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCF--PVPNFQRVCGCPYGMRL 1006

Query: 317  LENGKTCKDGAT 328
              N  TC+   T
Sbjct: 1007 ASNHLTCEGDPT 1018



 Score =  119 bits (297), Expect = 3e-26
 Identities = 105/415 (25%), Positives = 174/415 (41%), Gaps = 73/415 (17%)

Query: 900  CSHLCLAVPVGGFVCGCPAHYSLNADNRT--------------------------CSAPT 933
            C   C  +  GGF+C C A +  N  +RT                          C    
Sbjct: 3975 CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCAD 4034

Query: 934  TFLLFSQKSAINRMVIDEQQSPDIILP------------------IHSLRNVRAIDYD-- 973
             F   S +    +    E  SP ++LP                  +     ++A+DYD  
Sbjct: 4035 GFTSMSDRPG--KRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWD 4092

Query: 974  PLDKQLYWI-------DSRQNMIRKAQ-EDGSQGFTVVVSSVPSQ-NLEIQPYDLSIDIY 1024
            P D  L  +        SR   I++A   +   G   +V  V  +    +QP  +++D  
Sbjct: 4093 PKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWV 4152

Query: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
             R+IYW+      I V +LDGR    ++  + D+P A+ VNP+ G M++T+   + PKIE
Sbjct: 4153 GRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD-WGKEPKIE 4211

Query: 1085 RAALDGTEREVLFFSGLSKPIALALD-SRLGKLFWADSDLRRIESSDLSGANRIVLEDSN 1143
             A ++G +R +L F  L  P  L++D     +++W+D     IE+    G +R V+    
Sbjct: 4212 SAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIA-KE 4270

Query: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR 1203
             + P  L +FE+ LYWI K++  + K +  G+  + K       L+ +    +L   +  
Sbjct: 4271 AMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSV 4330

Query: 1204 QHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD---------ELSCGEPPTC 1249
             + C Q    CSH+CL++  G + C+CP     ++          EL    PP C
Sbjct: 4331 PNLCKQI---CSHLCLLRPGGYS-CACPQGSSFIEGSTTECDAAIELPINLPPPC 4381



 Score =  112 bits (279), Expect = 4e-24
 Identities = 53/126 (42%), Positives = 72/126 (57%), Gaps = 3/126 (2%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG 1298
            DE       TCS  Q TC  G+  CIP  +RCD   +C D +DE +C   +  Q  C +G
Sbjct: 98   DERQDCSQSTCSSHQITCSNGQ--CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNG 155

Query: 1299 QCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDEL 1358
             C + + +C+   +C+D SDE NC  +CL ++F C NG+CI +   CDH+ DC D SDE 
Sbjct: 156  ACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEH 215

Query: 1359 DC-YPT 1363
             C YPT
Sbjct: 216  ACNYPT 221



 Score =  110 bits (276), Expect = 8e-24
 Identities = 58/132 (43%), Positives = 76/132 (57%), Gaps = 8/132 (6%)

Query: 1239 DELSCGEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQC 1295
            DE  C E  TC P   F C      CIP+ W+CDG  +C D+SDE NC    C+ES+F+C
Sbjct: 3710 DEQGC-EERTCHPVGDFRCKNHH--CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC 3766

Query: 1296 ASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDK 1354
             + QCI     C+   +C D SDE++CE+  C  + F+C +G C+    KCD + DC D 
Sbjct: 3767 VNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDA 3826

Query: 1355 SDELDCYPTEEP 1366
            SDE DC PT  P
Sbjct: 3827 SDEADC-PTRFP 3837



 Score =  110 bits (274), Expect = 1e-23
 Identities = 61/151 (40%), Positives = 80/151 (52%), Gaps = 15/151 (9%)

Query: 1224 GTTRCSCPMHLVLLQDELSCGEPPT---CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHS 1280
            G    +C + L L+    +C  P +   C    F C +G   CIP  WRCDG  +C D +
Sbjct: 4    GPAAVACTLLLALV----ACLAPASGQECDSAHFRCGSGH--CIPADWRCDGTKDCSDDA 57

Query: 1281 DELNCPV--CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKN--CEVLCLIDQFRCAN 1335
            DE+ C V  C +  F+C S GQCI  +  C+ D +C D SDE+    +  C   Q  C+N
Sbjct: 58   DEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSN 117

Query: 1336 GQCIGKHKKCDHNVDCSDKSDELDC-YPTEE 1365
            GQCI    +CDH  DC D +DE DC YPT E
Sbjct: 118  GQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148



 Score =  103 bits (258), Expect = 1e-21
 Identities = 51/127 (40%), Positives = 67/127 (52%), Gaps = 11/127 (8%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCA 1296
            DE +C  P  C+  +F C   +  CIP  W CD + +C D+SDE +C +  C    FQC 
Sbjct: 3750 DEENCA-PRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCT 3806

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCE------VLCLIDQFRCANGQCIGKHKKCDHNVD 1350
            SG C+   L+C+G A+C D SDE +C         C    F C N  CI  + KCD + D
Sbjct: 3807 SGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDD 3866

Query: 1351 CSDKSDE 1357
            C D SDE
Sbjct: 3867 CGDGSDE 3873



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 62/188 (32%), Positives = 88/188 (46%), Gaps = 32/188 (17%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCAS 1297
            DE  C + PTC  +Q TC  G   C   + +CD   +C D SDE+NC  +C  ++F C +
Sbjct: 138  DENDC-QYPTC--EQLTCDNGA--CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192

Query: 1298 GQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
            G+CI  A  C+ D +CQD SDE  C    C   QF C +G+CI ++  CD   DC D  D
Sbjct: 193  GECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252

Query: 1357 E----------LDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRML-CPRMKGD 1405
            E            C P E   P++   +              ++Y +C  +L CP  + +
Sbjct: 253  EDGCESGPHDVHKCSPREWSCPESGRCI--------------SIYKVCDGILDCPGREDE 298

Query: 1406 GETMTNDY 1413
              T T  Y
Sbjct: 299  NNTSTGKY 306



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 61/176 (34%), Positives = 80/176 (45%), Gaps = 19/176 (10%)

Query: 1201 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP---------PTCSP 1251
            E ++H C   N   S    V      R   P   V    ++ C +           TCS 
Sbjct: 2937 EDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVC-DGDVDCTDGYDENQNCTRRTCSE 2995

Query: 1252 QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCIDGALRCNG 1309
             +FTC  G   CIP  +RCD   +C D+SDE  C    C ++QF C +G+CI     C+ 
Sbjct: 2996 NEFTCGYGL--CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDE 3053

Query: 1310 DANCQDKSDE-----KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            D +C D SDE        E  C   +F+C NG+CI   K C+H  DC D SDE  C
Sbjct: 3054 DNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 54/129 (41%), Positives = 67/129 (51%), Gaps = 9/129 (6%)

Query: 1249 CSPQQFTCFTG---EIDCIPVAWRCDGFTECEDHSDE-LNCP--VCSESQFQCASGQCID 1302
            CS  +F C      +  CIP +W CDG  +C D  DE  NC    CSE++F C  G CI 
Sbjct: 2948 CSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIP 3007

Query: 1303 GALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD-- 1359
               RC+   +C D SDE+ C    C  +QF C NG+CI K   CD + DC D SDEL   
Sbjct: 3008 KIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHL 3067

Query: 1360 CYPTEEPAP 1368
            C+  E   P
Sbjct: 3068 CHTPEPTCP 3076



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 56/134 (41%), Positives = 69/134 (51%), Gaps = 12/134 (8%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-----VCSESQF 1293
            DE+ C     C+  QF C +G+  CI V  RCDG  +C D+SDE  CP     +C   +F
Sbjct: 1179 DEVGC--VLNCTASQFKCASGD-KCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEF 1235

Query: 1294 QCAS-GQCIDGALRCNGDANCQDKSDEKNCEV--LCLIDQFRCANGQCIGKHKKCDHNVD 1350
            QC   G CI     C+G  +C   SDE N  V   C    F C NG CI +   CD + D
Sbjct: 1236 QCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDND 1295

Query: 1351 CSDKSDELDCYPTE 1364
            C D SDE DC PT+
Sbjct: 1296 CGDMSDEKDC-PTQ 1308



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 52/127 (40%), Positives = 67/127 (52%), Gaps = 10/127 (7%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCPVCSESQFQ 1294
            DE +C +  TC      C    I CIP  + CDG  +C D+SDE         CS S+FQ
Sbjct: 2813 DEKNCPDR-TCQSGYTKCHNSNI-CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQ 2870

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEK----NCEVLCLIDQFRCANGQCIGKHKKCDHNVD 1350
            CASG+CI     C+ + +C D SDE     + E  CL D+F+C  G+CI     CD + D
Sbjct: 2871 CASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDND 2930

Query: 1351 CSDKSDE 1357
            C D SDE
Sbjct: 2931 CGDMSDE 2937



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 59/167 (35%), Positives = 83/167 (49%), Gaps = 24/167 (14%)

Query: 1204 QHP-CAQ---DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTG 1259
            Q+P C Q   DNG C +        + +C   +      DE++C E   C   +F+C  G
Sbjct: 143  QYPTCEQLTCDNGACYNT-------SQKCDWKVDCRDSSDEINCTE--ICLHNEFSCGNG 193

Query: 1260 EIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCIDGALRCNGDANCQDKS 1317
            E  CIP A+ CD   +C+D SDE  C  P C   QF C SG+CI     C+G+ +C+D  
Sbjct: 194  E--CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNG 251

Query: 1318 DEKNCEV------LCLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDE 1357
            DE  CE        C   ++ C  +G+CI  +K CD  +DC  + DE
Sbjct: 252  DEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 55/162 (33%), Positives = 65/162 (40%), Gaps = 51/162 (31%)

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-----------------LNCPV--- 1287
            TC P QF C  G   CIP AW+CD   +C DHSDE                  +C     
Sbjct: 3634 TCRPGQFRCANGR--CIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691

Query: 1288 ----------------------CSE------SQFQCASGQCIDGALRCNGDANCQDKSDE 1319
                                  C E        F+C +  CI    +C+G  +C D SDE
Sbjct: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751

Query: 1320 KNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            +NC    C   +FRC N QCI     CDH  DC D SDE DC
Sbjct: 3752 ENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 52/132 (39%), Positives = 66/132 (50%), Gaps = 15/132 (11%)

Query: 1242 SCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-----LNCPVCSESQFQC 1295
            SCG    TC   +F C  G   CIP  W CDG  +C D SDE          CS+S+F C
Sbjct: 2898 SCGHSERTCLADEFKCDGGR--CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLC 2955

Query: 1296 ASG-----QCIDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348
             +      +CI  +  C+GD +C D  DE +NC    C  ++F C  G CI K  +CD +
Sbjct: 2956 VNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRH 3015

Query: 1349 VDCSDKSDELDC 1360
             DC D SDE  C
Sbjct: 3016 NDCGDYSDERGC 3027



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 59/171 (34%), Positives = 77/171 (45%), Gaps = 26/171 (15%)

Query: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDC-----IP 1265
            +G C H  L K DG+  C      +   DE  C   PT  P    C     +C     IP
Sbjct: 3807 SGHCVHSEL-KCDGSADC------LDASDEADC---PTRFPDGAYCQATMFECKNHVCIP 3856

Query: 1266 VAWRCDGFTECEDHSDE-----LNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDE- 1319
              W+CDG  +C D SDE     L+ P  S ++F+C + +CI     CNG  +C D +DE 
Sbjct: 3857 PYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDET 3916

Query: 1320 -----KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEE 1365
                 K     C   +++C NG CI     CD   DC D SDEL C   +E
Sbjct: 3917 EEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKE 3967



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 52/146 (35%), Positives = 62/146 (42%), Gaps = 18/146 (12%)

Query: 1225 TTRCSCPMHLVLLQDELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
            T RC          DE  C   P   C   +F C    I CIP  W CDG  +C   SDE
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGI-CIPNFWECDGHPDCLYGSDE 1262

Query: 1283 LNCPV---CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQ-- 1337
             N  V   C  S F C +G CI  A  C+ D +C D SDEK+C        FRC + Q  
Sbjct: 1263 HNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT----QPFRCPSWQWQ 1318

Query: 1338 ------CIGKHKKCDHNVDCSDKSDE 1357
                  C+     CD   DC + +DE
Sbjct: 1319 CLGHNICVNLSVVCDGIFDCPNGTDE 1344



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 37/94 (39%), Positives = 49/94 (52%), Gaps = 3/94 (3%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL-CLIDQFRC-ANGQCIGKHKKC 1345
            C  + F+C SG CI    RC+G  +C D +DE  C V+ C    F+C + GQCI     C
Sbjct: 28   CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87

Query: 1346 DHNVDCSDKSDE-LDCYPTEEPAPQATNTVGSVI 1378
            D + DC D SDE  DC  +   + Q T + G  I
Sbjct: 88   DQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCI 121



 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 53/168 (31%), Positives = 71/168 (42%), Gaps = 25/168 (14%)

Query: 1200 QEYRQHPCAQDNGGCSH-ICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFT 1258
            Q   +  C+++   C + +C+ K     RC          DE  C    TC   QFTC  
Sbjct: 2986 QNCTRRTCSENEFTCGYGLCIPK---IFRCDRHNDCGDYSDERGCLYQ-TCQQNQFTCQN 3041

Query: 1259 GEIDCIPVAWRCDGFTECEDHSDELN--C----PVCSESQFQCASGQCIDGALRCNGDAN 1312
            G   CI   + CD   +C D SDEL   C    P C   +F+C +G+CI+    CN   +
Sbjct: 3042 GR--CISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDD 3099

Query: 1313 CQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C D SDEK C +        C +    G    CDHN  C+D      C
Sbjct: 3100 CLDNSDEKGCGI------NECHDPSISG----CDHN--CTDTLTSFYC 3135



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 6/144 (4%)

Query: 38   NGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSP 97
            +G+    ++   L+  AA+      GL++W+D  +E    + +   E    +V   L  P
Sbjct: 4172 DGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWP 4231

Query: 98   DGLACDWL-GEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYW-- 154
             GL+ D+L  +++YW+D + + IE    DG+ R+V+  + ++     +LD     +YW  
Sbjct: 4232 TGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMN---PYSLDIFEDQLYWIS 4288

Query: 155  TDWGEVPKIERAGMDGSSRFIIIN 178
             + GEV K  + G     + +++N
Sbjct: 4289 KEKGEVWKQNKFGQGKKEKTLVVN 4312



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 24/57 (42%), Positives = 26/57 (45%), Gaps = 1/57 (1%)

Query: 1307 CNGDANCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
            C  D      S    C  +C   QF CAN + CI    KCD   DCSD SDEL   P
Sbjct: 3493 CPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCP 3549



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 28/118 (23%), Positives = 43/118 (36%), Gaps = 40/118 (33%)

Query: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
            C+  NGGC+H C+ +  G  +C CP+  +L  D  +C                +ID    
Sbjct: 1353 CSDFNGGCTHECVQEPFG-AKCLCPLGFLLANDSKTC---------------EDID---- 1392

Query: 1267 AWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV 1324
               CD    C  H   +                   G+ RC+ D     +SD + C+V
Sbjct: 1393 --ECDILGSCSQHCYNMR------------------GSFRCSCDTGYMLESDGRTCKV 1430


>gi|32698824 low density lipoprotein receptor-related protein 5-like
           [Homo sapiens]
          Length = 252

 Score =  329 bits (843), Expect = 2e-89
 Identities = 154/246 (62%), Positives = 190/246 (77%)

Query: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
           +EG++YWTDDEV AIRR+++DGSG+Q ++  +I  PD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 430 TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489
           T LN T  KIL+SED++EPRAI L P +G  YW DWGE P+I+RA LD  +  VLVN SL
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 490 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549
           GWPNGLALD  EGK+YWGDAKTDKIE ++ D T R+ L++DK+PHIF FTLLGD++YWT 
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180

Query: 550 WQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQG 609
           WQ  SI+RVHK  A R+VIIDQLPDLMGLKA NV +V+G+NP A+ NGG +     RP  
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240

Query: 610 LRCACP 615
              A P
Sbjct: 241 PGLAAP 246



 Score =  177 bits (450), Expect = 6e-44
 Identities = 92/243 (37%), Positives = 137/243 (56%), Gaps = 5/243 (2%)

Query: 63  GLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122
           G +YW+D    AI+R   + +   Q ++ + +  PD +A +W+   LYWT + T  IEV+
Sbjct: 3   GHVYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 123 NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182
            L+ +  K+L  +++D+PRAIAL P  G  YW DWGE P+I+RA +D     +++N+ + 
Sbjct: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121

Query: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
           WPNGL LD +E KLYW DAK + I   ++D T RQ ++K  LPH F  TL  D +YWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181

Query: 243 STHSILACNKYTGEGLREIHSD-IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP 301
             HSI   +K      R++  D +   M + A +  +    TNP    NGG +      P
Sbjct: 182 QHHSIKRVHKVKAN--RDVIIDQLPDLMGLKAVNVDKVV-GTNPHADRNGGAATCASSRP 238

Query: 302 VKP 304
            +P
Sbjct: 239 TQP 241



 Score =  166 bits (421), Expect = 1e-40
 Identities = 85/228 (37%), Positives = 132/228 (57%), Gaps = 3/228 (1%)

Query: 673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVS 732
           +  +YWTD  +  I RA+++GS  + ++   ++ P+ +AV+W+ ++LYW  TGT  IEV+
Sbjct: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 733 KLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVG 791
            L+    ++LV +D+D PRA+AL P  G  YW +WG  P+I RA +D  E   LV  ++G
Sbjct: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121

Query: 792 RANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE-VIADDLPHPFGLTQYQDYIYWTDW 850
             NGL +D  + +LYW D  T+ IE+ ++    R+ ++ D LPH F  T   D+IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181

Query: 851 SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNG 898
              SI+R +K    NR +I   L  +M +   +  +  G N  A  NG
Sbjct: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228



 Score =  109 bits (273), Expect = 2e-23
 Identities = 71/242 (29%), Positives = 122/242 (50%), Gaps = 12/242 (4%)

Query: 975  LDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA 1034
            ++  +YW D     IR+A  DGS   T++ + +        P D++++  +R +YWT   
Sbjct: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND------PDDIAVNWVARSLYWTHTG 54

Query: 1035 TNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTERE 1094
            T  I VT L+  S  +++  + D PRA+ ++PE G  Y+ +  E +P+I+RA LD  E  
Sbjct: 55   TEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELR 113

Query: 1095 VLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
            VL  + L  P  LALD + GKL+W D+   +IE+  +    R  L    +      T+  
Sbjct: 114  VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLG 173

Query: 1155 NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQE-YRQHPCAQDNGG 1213
            +++YW   Q   I+++     + +      I QL D+  +K +N+ +    +P A  NGG
Sbjct: 174  DFIYWTAWQHHSIKRV----HKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGG 229

Query: 1214 CS 1215
             +
Sbjct: 230  AA 231



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 3/114 (2%)

Query: 353 VLQLEDIRHAIAIDYDPVEGYIYWTD-DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
           +L  ED+    AI   P  G  YW D  E   I+R+ +D    + +V A +  P+G+A+D
Sbjct: 70  ILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD 129

Query: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465
                LYW D  TD+IE   ++ T R+ L+ + L  P       +  ++YWT W
Sbjct: 130 LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAW 181



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)

Query: 34  VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92
           V   N   +  +V   +++  A+      GL YW D  E   IKR   ++ E ++ +V +
Sbjct: 60  VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQE-LRVLVNA 118

Query: 93  GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            L  P+GLA D    KLYW D++T++IE  ++D + R+ L   +L  P          F+
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFI 176

Query: 153 YWTDWGEVPKIERAGMDGSSRFIIIN 178
           YWT W +   I+R     ++R +II+
Sbjct: 177 YWTAW-QHHSIKRVHKVKANRDVIID 201



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 58/271 (21%)

Query: 193 EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWST-HSILA 249
           E  +YW D ++  I ++ LDG+  Q ++   +  P   A+      LYWT   T H  + 
Sbjct: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 250 CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309
           C   T   +  +  D+  P  I          A +P                        
Sbjct: 62  CLNSTSHKIL-VSEDMDEPRAI----------ALHP------------------------ 86

Query: 310 CPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP 369
                         + G T  +      +++R +LD  +   +V       + +A+D   
Sbjct: 87  --------------EMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQ- 131

Query: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
            EG +YW D +   I    +D +  Q ++  ++ H     +  +   +YWT      I+ 
Sbjct: 132 -EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSIKR 188

Query: 430 TRLNGTMRKILISE--DLEEPRAIVLDPMVG 458
                  R ++I +  DL   +A+ +D +VG
Sbjct: 189 VHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219


>gi|209447022 low density lipoprotein receptor-related protein
           5-like [Homo sapiens]
          Length = 252

 Score =  329 bits (843), Expect = 2e-89
 Identities = 154/246 (62%), Positives = 190/246 (77%)

Query: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
           +EG++YWTDDEV AIRR+++DGSG+Q ++  +I  PD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 1   MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 430 TRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSL 489
           T LN T  KIL+SED++EPRAI L P +G  YW DWGE P+I+RA LD  +  VLVN SL
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 490 GWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549
           GWPNGLALD  EGK+YWGDAKTDKIE ++ D T R+ L++DK+PHIF FTLLGD++YWT 
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180

Query: 550 WQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQG 609
           WQ  SI+RVHK  A R+VIIDQLPDLMGLKA NV +V+G+NP A+ NGG +     RP  
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAATCASSRPTQ 240

Query: 610 LRCACP 615
              A P
Sbjct: 241 PGLAAP 246



 Score =  177 bits (450), Expect = 6e-44
 Identities = 92/243 (37%), Positives = 137/243 (56%), Gaps = 5/243 (2%)

Query: 63  GLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122
           G +YW+D    AI+R   + +   Q ++ + +  PD +A +W+   LYWT + T  IEV+
Sbjct: 3   GHVYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 123 NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182
            L+ +  K+L  +++D+PRAIAL P  G  YW DWGE P+I+RA +D     +++N+ + 
Sbjct: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121

Query: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
           WPNGL LD +E KLYW DAK + I   ++D T RQ ++K  LPH F  TL  D +YWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181

Query: 243 STHSILACNKYTGEGLREIHSD-IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSP 301
             HSI   +K      R++  D +   M + A +  +    TNP    NGG +      P
Sbjct: 182 QHHSIKRVHKVKAN--RDVIIDQLPDLMGLKAVNVDKVV-GTNPHADRNGGAATCASSRP 238

Query: 302 VKP 304
            +P
Sbjct: 239 TQP 241



 Score =  166 bits (421), Expect = 1e-40
 Identities = 85/228 (37%), Positives = 132/228 (57%), Gaps = 3/228 (1%)

Query: 673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVS 732
           +  +YWTD  +  I RA+++GS  + ++   ++ P+ +AV+W+ ++LYW  TGT  IEV+
Sbjct: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 733 KLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVG 791
            L+    ++LV +D+D PRA+AL P  G  YW +WG  P+I RA +D  E   LV  ++G
Sbjct: 62  CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121

Query: 792 RANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNRE-VIADDLPHPFGLTQYQDYIYWTDW 850
             NGL +D  + +LYW D  T+ IE+ ++    R+ ++ D LPH F  T   D+IYWT W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181

Query: 851 SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNG 898
              SI+R +K    NR +I   L  +M +   +  +  G N  A  NG
Sbjct: 182 QHHSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228



 Score =  109 bits (273), Expect = 2e-23
 Identities = 71/242 (29%), Positives = 122/242 (50%), Gaps = 12/242 (4%)

Query: 975  LDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEA 1034
            ++  +YW D     IR+A  DGS   T++ + +        P D++++  +R +YWT   
Sbjct: 1    MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND------PDDIAVNWVARSLYWTHTG 54

Query: 1035 TNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTERE 1094
            T  I VT L+  S  +++  + D PRA+ ++PE G  Y+ +  E +P+I+RA LD  E  
Sbjct: 55   TEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELR 113

Query: 1095 VLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
            VL  + L  P  LALD + GKL+W D+   +IE+  +    R  L    +      T+  
Sbjct: 114  VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLG 173

Query: 1155 NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQE-YRQHPCAQDNGG 1213
            +++YW   Q   I+++     + +      I QL D+  +K +N+ +    +P A  NGG
Sbjct: 174  DFIYWTAWQHHSIKRV----HKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGG 229

Query: 1214 CS 1215
             +
Sbjct: 230  AA 231



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 3/114 (2%)

Query: 353 VLQLEDIRHAIAIDYDPVEGYIYWTD-DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVD 411
           +L  ED+    AI   P  G  YW D  E   I+R+ +D    + +V A +  P+G+A+D
Sbjct: 70  ILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALD 129

Query: 412 WVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465
                LYW D  TD+IE   ++ T R+ L+ + L  P       +  ++YWT W
Sbjct: 130 LQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAW 181



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)

Query: 34  VDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA-IKRTEFNKTESVQNVVVS 92
           V   N   +  +V   +++  A+      GL YW D  E   IKR   ++ E ++ +V +
Sbjct: 60  VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQE-LRVLVNA 118

Query: 93  GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            L  P+GLA D    KLYW D++T++IE  ++D + R+ L   +L  P          F+
Sbjct: 119 SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFI 176

Query: 153 YWTDWGEVPKIERAGMDGSSRFIIIN 178
           YWT W +   I+R     ++R +II+
Sbjct: 177 YWTAW-QHHSIKRVHKVKANRDVIID 201



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 58/271 (21%)

Query: 193 EQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL--PHPFALTLFEDILYWTDWST-HSILA 249
           E  +YW D ++  I ++ LDG+  Q ++   +  P   A+      LYWT   T H  + 
Sbjct: 2   EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61

Query: 250 CNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCA 309
           C   T   +  +  D+  P  I          A +P                        
Sbjct: 62  CLNSTSHKIL-VSEDMDEPRAI----------ALHP------------------------ 86

Query: 310 CPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP 369
                         + G T  +      +++R +LD  +   +V       + +A+D   
Sbjct: 87  --------------EMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQ- 131

Query: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV 429
            EG +YW D +   I    +D +  Q ++  ++ H     +  +   +YWT      I+ 
Sbjct: 132 -EGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQHHSIKR 188

Query: 430 TRLNGTMRKILISE--DLEEPRAIVLDPMVG 458
                  R ++I +  DL   +A+ +D +VG
Sbjct: 189 VHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score =  244 bits (624), Expect = 4e-64
 Identities = 121/328 (36%), Positives = 195/328 (59%), Gaps = 10/328 (3%)

Query: 9   LACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWS 68
           LA   C  +   P L++ NRRD+R +     ++    +V  L +  A+D   +   ++W+
Sbjct: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVALDADIAAQKLFWA 486

Query: 69  DVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSL 128
           D+S++AI     +        ++  + +P  +A DW+ + +YWTD+ +  I V+ LDG+ 
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546

Query: 129 RKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLT 188
           RK LF  +L +P +IA+DP SGF+YW+DWGE  KIE+AGM+G  R  ++ ++I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606

Query: 189 LDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHS 246
           LD  + +LYW D+KL+ +   +L+G +R+ V+K    L HP ALT+FED +YW D    +
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666

Query: 247 ILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC--GIDNGGCSHLCLMSPV-- 302
           +   NK+TG  L  + +++    DI  + +  QP+  N C   ++NGGC +LCL +P   
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIN 726

Query: 303 --KPFYQCACPTGVKLLENGKTCKDGAT 328
              P Y C+CP+G  + ENG+ C+  AT
Sbjct: 727 DHSPKYTCSCPSGYNVEENGRDCQSTAT 754



 Score =  222 bits (566), Expect = 2e-57
 Identities = 132/411 (32%), Positives = 197/411 (47%), Gaps = 58/411 (14%)

Query: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC---------------------- 627
           N C   NGGCSH+C     G  C C  GFELI D KTC                      
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416

Query: 628 --------------------IVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667
                               +  E  L+F+ R DIR+I LE       +    ++   AL
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQ--LRNTVAL 474

Query: 668 DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDY-PEGMAVDWLGKNLYWADTGT 726
           D D+   +++W D+S K I  A ++     HV      Y P  +AVDW+ K +YW D  +
Sbjct: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534

Query: 727 NRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786
             I V+ LDG  R+ L   DL  P ++A+DP  GF+YW++WG   KI++A M+G +R  L
Sbjct: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594

Query: 787 V-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLTQYQ 842
           V  ++   NG+T+D  K RLYW D   +++ S ++ G +R ++    + L HP  LT ++
Sbjct: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654

Query: 843 DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECAS--SNGH 899
           D +YW D    ++  ANK +G     +  +L+   DI+V+H   Q SG N C     NG 
Sbjct: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714

Query: 900 CSHLCLAVP-----VGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAIN 945
           C +LCL  P        + C CP+ Y++  + R C +  T + +S+    N
Sbjct: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTN 765



 Score =  216 bits (550), Expect = 1e-55
 Identities = 133/453 (29%), Positives = 215/453 (47%), Gaps = 77/453 (16%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C ++NGGCSH+C    +   Y+C C  G +L++  KTC D                  
Sbjct: 358 NECLVNNGGCSHICKDLVIG--YECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLK 414

Query: 326 -----------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
                                  G    L+   R D+R+I L+  ++  +V   E +R+ 
Sbjct: 415 GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV---EQLRNT 471

Query: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
           +A+D D     ++W D   +AI  + ID   G    +   + +P  IAVDWV + +YWTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531

Query: 422 TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDR 481
             +  I V  L+GT RK L + DL EP +I +DP+ G++YW+DWGE  KIE+A ++G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591

Query: 482 VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHIFGFT 539
             LV   + WPNG+ LD  + ++YW D+K   +  ++ +G  RR++++  + + H    T
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALT 651

Query: 540 LLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI---GSNPCAE- 594
           +  D VYW D +  ++   +K   +E   +++ L D   +     H ++   G N C E 
Sbjct: 652 IFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV--YHELVQPSGKNWCEED 709

Query: 595 -ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRR--- 644
            ENGGC +LCL  PQ         C+CP G+ +  + + C      + +S   D      
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEI 769

Query: 645 ----------ISLETNNNNVAIPLTGVKEASAL 667
                     I++ T  + V++P  G   A A+
Sbjct: 770 SATSGLVPGGINVTTAVSEVSVPPKGTSAAWAI 802



 Score =  143 bits (361), Expect = 1e-33
 Identities = 107/354 (30%), Positives = 179/354 (50%), Gaps = 27/354 (7%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMV 948
            +EC +  G CS +C+ +  GG+ C C   Y ++     C A      L+F+ +  I ++ 
Sbjct: 398  DECQNP-GICSQICINLK-GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455

Query: 949  IDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTV-VVSSV 1007
            ++ ++    I  +  LRN  A+D D   ++L+W D  Q  I  A  D   G  V ++ +V
Sbjct: 456  LERKE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512

Query: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE 1067
                    P  +++D   + IYWT  A+  I+V  LDG     +   +   P ++ V+P 
Sbjct: 513  ------YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL 566

Query: 1068 KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIE 1127
             G++Y+++  E + KIE+A ++G +R  L  + +  P  + LD    +L+W DS L  + 
Sbjct: 567  SGFVYWSDWGEPA-KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625

Query: 1128 SSDLSGAN-RIVLEDSNIL-QPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQAR 1184
            S DL+G + RIVL+    L  P+ LT+FE+ +YWID + + +   +  TG E  T V   
Sbjct: 626  SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN-N 684

Query: 1185 IAQLSDIHAVKELNLQEYRQHPCAQD--NGGCSHICLVK---GDGTTR--CSCP 1231
            +    DI    EL +Q   ++ C +D  NGGC ++CL      D + +  CSCP
Sbjct: 685  LNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737



 Score =  115 bits (287), Expect = 4e-25
 Identities = 60/132 (45%), Positives = 75/132 (56%), Gaps = 13/132 (9%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NC---PV----CS 1289
            DEL C  PPTC   +F C T    CIP++W CD   +C D SDE    C   PV    C 
Sbjct: 184  DELDCA-PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240

Query: 1290 ESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348
             S+ QC SG+CI    RC+GD +C+D SDE NC    C  DQF C +G CI   ++C+  
Sbjct: 241  ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300

Query: 1349 VDCSDKSDELDC 1360
             DC D SDE++C
Sbjct: 301  RDCVDGSDEVNC 312



 Score =  108 bits (270), Expect = 4e-23
 Identities = 55/124 (44%), Positives = 71/124 (57%), Gaps = 11/124 (8%)

Query: 1243 CGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
            CG  P     C   +  C +GE  CI   WRCDG  +C+D SDE+NCP   C   QF+C 
Sbjct: 229  CGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL--CL-IDQFRCANGQCIGKHKKCDHNVDCSD 1353
             G CI G+ +CNG  +C D SDE NC+ +  CL   +F+C +G+CI   K C+   DC D
Sbjct: 287  DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346

Query: 1354 KSDE 1357
             SDE
Sbjct: 347  WSDE 350



 Score =  107 bits (268), Expect = 7e-23
 Identities = 62/159 (38%), Positives = 85/159 (53%), Gaps = 17/159 (10%)

Query: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRC 1270
            NG C  + L K DG   C      V   DE +C +  TC+   F C  G+  C+P  W+C
Sbjct: 42   NGRCITL-LWKCDGDEDC------VDGSDEKNCVKK-TCAESDFVCNNGQ--CVPSRWKC 91

Query: 1271 DGFTECEDHSDE----LNCPVCSESQFQCA--SGQCIDGALRCNGDANCQDKSDEKNC-E 1323
            DG  +CED SDE     +   C   +  C   S QCI  + RC+G+ +C    DE+NC  
Sbjct: 92   DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN 151

Query: 1324 VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362
            + C  D+F C++G+CI ++  C+   DCSD SDELDC P
Sbjct: 152  ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP 190



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 36/71 (50%), Positives = 44/71 (61%), Gaps = 1/71 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C  SQFQC +G+CI    +C+GD +C D SDEKNC +  C    F C NGQC+    KCD
Sbjct: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92

Query: 1347 HNVDCSDKSDE 1357
             + DC D SDE
Sbjct: 93   GDPDCEDGSDE 103



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 18/35 (51%), Positives = 22/35 (62%)

Query: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C   QF+C NG+CI    KCD + DC D SDE +C
Sbjct: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 6/53 (11%)

Query: 1199 LQEYRQHPCAQDNGGCSHIC--LVKGDGTTRCSCPMHLVLLQDELSCGEPPTC 1249
            L+E   + C  +NGGCSHIC  LV G     C C     L+ D  +CG+   C
Sbjct: 352  LKECHINECLVNNGGCSHICKDLVIG---YECDCAAGFELI-DRKTCGDIDEC 400


>gi|61744471 low density lipoprotein receptor-related protein 8
           isoform 1 precursor [Homo sapiens]
          Length = 963

 Score =  243 bits (619), Expect = 1e-63
 Identities = 143/428 (33%), Positives = 219/428 (51%), Gaps = 62/428 (14%)

Query: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPEAF--------- 633
           G N C   NGGCSH+C     G  C CP GF+L+      D+  C  P+A          
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395

Query: 634 ----------------------------LLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665
                                       L+F+ R ++RRI L   N +  IP+  +K   
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453

Query: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721
           ALD +V  NRIYW D+S + I  A+M+ ++     E +++  L  PEG+AVDW+ K++YW
Sbjct: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513

Query: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
            D+G   I V+ +DG  R+ L  ++L  PRA+A+DP  GFMYW++WG + KI+++ ++G 
Sbjct: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573

Query: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837
           +R TLV  N+   NG+T+D   +RLYW D   + + S +  G NR+ +    D L HPFG
Sbjct: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633

Query: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896
           +  ++D ++WTD    +I  AN+ +G   +I+  +L+   DI++FH  +Q    + C  S
Sbjct: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693

Query: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947
              NG C +LCL  P        + C CP    L  D + C  AP +    +  S + R 
Sbjct: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753

Query: 948 VIDEQQSP 955
           V    ++P
Sbjct: 754 VPATTRAP 761



 Score =  231 bits (589), Expect = 4e-60
 Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)

Query: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
           +P L++ NR ++R +D    K N + ++  L++  A+D   +   IYW D+S   I    
Sbjct: 421 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478

Query: 80  FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
            +K      Q V++   L SP+GLA DW+ + +YWTDS    I V+ +DG  R+ LF + 
Sbjct: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538

Query: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
           L +PRAIA+DP  GFMYW+DWG+  KIE++G++G  R  +++  I WPNG+TLD   Q+L
Sbjct: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598

Query: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
           YW D+KL+ +   +  G NR+ ++  +  L HPF + +FED ++WTD    +I + N+  
Sbjct: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658

Query: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
           G  +  +  ++ +P DI  F + +QP A + C +    NGGC +LCL +P      P Y 
Sbjct: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718

Query: 308 CACPTGVKLLENGKTC 323
           CACP  + L  + K C
Sbjct: 719 CACPDTMWLGPDMKRC 734



 Score =  213 bits (541), Expect = 2e-54
 Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C  +NGGCSH+C  + +K  ++C CP G +LL+  KTC D                  
Sbjct: 338 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 394

Query: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
                                   G +  L+   R ++RRI L   +++ ++  L+++  
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 452

Query: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNL 417
            +A+D +     IYW D   R I  +++D +      + ++  Q+  P+G+AVDWV +++
Sbjct: 453 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511

Query: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
           YWTD+G   I V  ++G  R+ L S +L EPRAI +DP+ G+MYW+DWG+  KIE++ L+
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571

Query: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
           G DR  LV+ ++ WPNG+ LD    ++YW D+K  ++  ++  G  R+ L+   D + H 
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631

Query: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
           FG  +  D V+WTD +  +I   ++    E  ++ + L         N H ++       
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 683

Query: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
               + C    + NGGC +LCL  PQ         CACP    L  DMK C
Sbjct: 684 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734



 Score =  142 bits (357), Expect = 3e-33
 Identities = 117/458 (25%), Positives = 193/458 (42%), Gaps = 81/458 (17%)

Query: 889  GWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC------------------- 929
            G NEC  +NG CSH+C  + +G F C CPA + L  D +TC                   
Sbjct: 336  GLNECLHNNGGCSHICTDLKIG-FECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNY 393

Query: 930  ------------------------SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
                                    +  +  L+F+ +  + R+ + ++    +I     L+
Sbjct: 394  KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLK 450

Query: 966  NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLS 1020
            NV A+D +    ++YW D     I  A  D +       S    Q + I      P  L+
Sbjct: 451  NVVALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLA 503

Query: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
            +D   ++IYWT      I+V  +DG     +       PRA+ V+P +G+MY+++  +++
Sbjct: 504  VDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA 563

Query: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1140
             KIE++ L+G +R+ L    +  P  + LD    +L+W DS L ++ S D SG NR  L 
Sbjct: 564  -KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622

Query: 1141 DSN--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELN 1198
             S   +  P G+ VFE+ ++W D +    E I    R    ++      L++ H +   +
Sbjct: 623  SSTDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFH 679

Query: 1199 LQEYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPT 1248
              +  + P A     Q NGGC ++CL     ++      C+CP  + L  D   C   P 
Sbjct: 680  ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ 739

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282
             S    T  +     +P   R  G T      ++HS E
Sbjct: 740  -STSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 776



 Score =  106 bits (265), Expect = 2e-22
 Identities = 60/175 (34%), Positives = 83/175 (47%), Gaps = 24/175 (13%)

Query: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE--------PPTCSPQQFTCF-TGE 1260
            D  GC+ +C          SC   + +   +  CG+         P C P++F C   G 
Sbjct: 159  DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218

Query: 1261 IDCIPVAWRCDGFTECEDHSDEL------------NCPVC--SESQFQCASGQCIDGALR 1306
              CIP  W CD   +CED SDE             + P    + SQF C SG+C+    R
Sbjct: 219  GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278

Query: 1307 CNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C+GD +C+DKSDE +C +  C  D+F+C +G C+   K C+   DC D SDE  C
Sbjct: 279  CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 48/128 (37%), Positives = 64/128 (50%), Gaps = 9/128 (7%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQFQ 1294
            DE  C +  TC+   FTC  G   CI   W+CDG  EC D SDE        VC   +  
Sbjct: 77   DEDDCPKK-TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133

Query: 1295 CA--SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
            C   S +C+  + RC+G+ +C+  +DE  C  LC   +F+C N  C+     CD + DC 
Sbjct: 134  CGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193

Query: 1353 DKSDELDC 1360
            D SDE  C
Sbjct: 194  DGSDERGC 201



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C + QFQC + +CI    RC+ D +C D SDE +C +  C    F C NG CI +  KCD
Sbjct: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106

Query: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
               +C D SDE +   T++  P
Sbjct: 107  GEEECPDGSDESEATCTKQVCP 128


>gi|65301119 low density lipoprotein receptor-related protein 8
           isoform 4 precursor [Homo sapiens]
          Length = 904

 Score =  243 bits (619), Expect = 1e-63
 Identities = 143/428 (33%), Positives = 219/428 (51%), Gaps = 62/428 (14%)

Query: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPEAF--------- 633
           G N C   NGGCSH+C     G  C CP GF+L+      D+  C  P+A          
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395

Query: 634 ----------------------------LLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665
                                       L+F+ R ++RRI L   N +  IP+  +K   
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453

Query: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721
           ALD +V  NRIYW D+S + I  A+M+ ++     E +++  L  PEG+AVDW+ K++YW
Sbjct: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513

Query: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
            D+G   I V+ +DG  R+ L  ++L  PRA+A+DP  GFMYW++WG + KI+++ ++G 
Sbjct: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573

Query: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837
           +R TLV  N+   NG+T+D   +RLYW D   + + S +  G NR+ +    D L HPFG
Sbjct: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633

Query: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896
           +  ++D ++WTD    +I  AN+ +G   +I+  +L+   DI++FH  +Q    + C  S
Sbjct: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693

Query: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947
              NG C +LCL  P        + C CP    L  D + C  AP +    +  S + R 
Sbjct: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753

Query: 948 VIDEQQSP 955
           V    ++P
Sbjct: 754 VPATTRAP 761



 Score =  231 bits (589), Expect = 4e-60
 Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)

Query: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
           +P L++ NR ++R +D    K N + ++  L++  A+D   +   IYW D+S   I    
Sbjct: 421 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478

Query: 80  FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
            +K      Q V++   L SP+GLA DW+ + +YWTDS    I V+ +DG  R+ LF + 
Sbjct: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538

Query: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
           L +PRAIA+DP  GFMYW+DWG+  KIE++G++G  R  +++  I WPNG+TLD   Q+L
Sbjct: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598

Query: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
           YW D+KL+ +   +  G NR+ ++  +  L HPF + +FED ++WTD    +I + N+  
Sbjct: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658

Query: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
           G  +  +  ++ +P DI  F + +QP A + C +    NGGC +LCL +P      P Y 
Sbjct: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718

Query: 308 CACPTGVKLLENGKTC 323
           CACP  + L  + K C
Sbjct: 719 CACPDTMWLGPDMKRC 734



 Score =  213 bits (541), Expect = 2e-54
 Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C  +NGGCSH+C  + +K  ++C CP G +LL+  KTC D                  
Sbjct: 338 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 394

Query: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
                                   G +  L+   R ++RRI L   +++ ++  L+++  
Sbjct: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 452

Query: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNL 417
            +A+D +     IYW D   R I  +++D +      + ++  Q+  P+G+AVDWV +++
Sbjct: 453 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511

Query: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
           YWTD+G   I V  ++G  R+ L S +L EPRAI +DP+ G+MYW+DWG+  KIE++ L+
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571

Query: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
           G DR  LV+ ++ WPNG+ LD    ++YW D+K  ++  ++  G  R+ L+   D + H 
Sbjct: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631

Query: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
           FG  +  D V+WTD +  +I   ++    E  ++ + L         N H ++       
Sbjct: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 683

Query: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
               + C    + NGGC +LCL  PQ         CACP    L  DMK C
Sbjct: 684 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734



 Score =  142 bits (357), Expect = 3e-33
 Identities = 117/458 (25%), Positives = 193/458 (42%), Gaps = 81/458 (17%)

Query: 889  GWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC------------------- 929
            G NEC  +NG CSH+C  + +G F C CPA + L  D +TC                   
Sbjct: 336  GLNECLHNNGGCSHICTDLKIG-FECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNY 393

Query: 930  ------------------------SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
                                    +  +  L+F+ +  + R+ + ++    +I     L+
Sbjct: 394  KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLK 450

Query: 966  NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLS 1020
            NV A+D +    ++YW D     I  A  D +       S    Q + I      P  L+
Sbjct: 451  NVVALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLA 503

Query: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
            +D   ++IYWT      I+V  +DG     +       PRA+ V+P +G+MY+++  +++
Sbjct: 504  VDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA 563

Query: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1140
             KIE++ L+G +R+ L    +  P  + LD    +L+W DS L ++ S D SG NR  L 
Sbjct: 564  -KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 622

Query: 1141 DSN--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELN 1198
             S   +  P G+ VFE+ ++W D +    E I    R    ++      L++ H +   +
Sbjct: 623  SSTDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFH 679

Query: 1199 LQEYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPT 1248
              +  + P A     Q NGGC ++CL     ++      C+CP  + L  D   C   P 
Sbjct: 680  ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ 739

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282
             S    T  +     +P   R  G T      ++HS E
Sbjct: 740  -STSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 776



 Score =  106 bits (265), Expect = 2e-22
 Identities = 60/175 (34%), Positives = 83/175 (47%), Gaps = 24/175 (13%)

Query: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE--------PPTCSPQQFTCF-TGE 1260
            D  GC+ +C          SC   + +   +  CG+         P C P++F C   G 
Sbjct: 159  DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218

Query: 1261 IDCIPVAWRCDGFTECEDHSDEL------------NCPVC--SESQFQCASGQCIDGALR 1306
              CIP  W CD   +CED SDE             + P    + SQF C SG+C+    R
Sbjct: 219  GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278

Query: 1307 CNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C+GD +C+DKSDE +C +  C  D+F+C +G C+   K C+   DC D SDE  C
Sbjct: 279  CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 48/128 (37%), Positives = 64/128 (50%), Gaps = 9/128 (7%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQFQ 1294
            DE  C +  TC+   FTC  G   CI   W+CDG  EC D SDE        VC   +  
Sbjct: 77   DEDDCPKK-TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133

Query: 1295 CA--SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
            C   S +C+  + RC+G+ +C+  +DE  C  LC   +F+C N  C+     CD + DC 
Sbjct: 134  CGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193

Query: 1353 DKSDELDC 1360
            D SDE  C
Sbjct: 194  DGSDERGC 201



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C + QFQC + +CI    RC+ D +C D SDE +C +  C    F C NG CI +  KCD
Sbjct: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106

Query: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
               +C D SDE +   T++  P
Sbjct: 107  GEEECPDGSDESEATCTKQVCP 128


>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score =  242 bits (617), Expect = 2e-63
 Identities = 119/324 (36%), Positives = 193/324 (59%), Gaps = 10/324 (3%)

Query: 9   LACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWS 68
           LA   C  +   P L++ NRRD+R +     ++    +V  L +  A+D   +   ++W+
Sbjct: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVALDADIAAQKLFWA 486

Query: 69  DVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSL 128
           D+S++AI     +        ++  + +P  +A DW+ + +YWTD+ +  I V+ LDG+ 
Sbjct: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546

Query: 129 RKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLT 188
           RK LF  +L +P +IA+DP SGF+YW+DWGE  KIE+AGM+G  R  ++ ++I WPNG+T
Sbjct: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606

Query: 189 LDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHS 246
           LD  + +LYW D+KL+ +   +L+G +R+ V+K    L HP ALT+FED +YW D    +
Sbjct: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666

Query: 247 ILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC--GIDNGGCSHLCLMSPV-- 302
           +   NK+TG  L  + +++    DI  + +  QP+  N C   ++NGGC +LCL +P   
Sbjct: 667 VYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIN 726

Query: 303 --KPFYQCACPTGVKLLENGKTCK 324
              P Y C+CP+G  + ENG+ C+
Sbjct: 727 DHSPKYTCSCPSGYNVEENGRDCQ 750



 Score =  218 bits (554), Expect = 5e-56
 Identities = 132/440 (30%), Positives = 213/440 (48%), Gaps = 79/440 (17%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C ++NGGCSH+C    +   Y+C C  G +L++  KTC D                  
Sbjct: 358 NECLVNNGGCSHICKDLVIG--YECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLK 414

Query: 326 -----------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
                                  G    L+   R D+R+I L+  ++  +V   E +R+ 
Sbjct: 415 GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV---EQLRNT 471

Query: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
           +A+D D     ++W D   +AI  + ID   G    +   + +P  IAVDWV + +YWTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531

Query: 422 TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDR 481
             +  I V  L+GT RK L + DL EP +I +DP+ G++YW+DWGE  KIE+A ++G DR
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591

Query: 482 VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHIFGFT 539
             LV   + WPNG+ LD  + ++YW D+K   +  ++ +G  RR++++  + + H    T
Sbjct: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALT 651

Query: 540 LLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI---GSNPCAE- 594
           +  D VYW D +  ++   +K   +E   +++ L D   +     H ++   G N C E 
Sbjct: 652 IFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV--YHELVQPSGKNWCEED 709

Query: 595 -ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL 647
            ENGGC +LCL  PQ         C+CP G+ +  + + C               +RI++
Sbjct: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC---------------QRINV 754

Query: 648 ETNNNNVAIPLTGVKEASAL 667
            T  + V++P  G   A A+
Sbjct: 755 TTAVSEVSVPPKGTSAAWAI 774



 Score =  217 bits (552), Expect = 8e-56
 Identities = 129/395 (32%), Positives = 190/395 (48%), Gaps = 58/395 (14%)

Query: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC---------------------- 627
           N C   NGGCSH+C     G  C C  GFELI D KTC                      
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416

Query: 628 --------------------IVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667
                               +  E  L+F+ R DIR+I LE       +    ++   AL
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQ--LRNTVAL 474

Query: 668 DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDY-PEGMAVDWLGKNLYWADTGT 726
           D D+   +++W D+S K I  A ++     HV      Y P  +AVDW+ K +YW D  +
Sbjct: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534

Query: 727 NRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786
             I V+ LDG  R+ L   DL  P ++A+DP  GF+YW++WG   KI++A M+G +R  L
Sbjct: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594

Query: 787 V-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLTQYQ 842
           V  ++   NG+T+D  K RLYW D   +++ S ++ G +R ++    + L HP  LT ++
Sbjct: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654

Query: 843 DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECAS--SNGH 899
           D +YW D    ++  ANK +G     +  +L+   DI+V+H   Q SG N C     NG 
Sbjct: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714

Query: 900 CSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC 929
           C +LCL  P        + C CP+ Y++  + R C
Sbjct: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749



 Score =  143 bits (361), Expect = 1e-33
 Identities = 107/354 (30%), Positives = 179/354 (50%), Gaps = 27/354 (7%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMV 948
            +EC +  G CS +C+ +  GG+ C C   Y ++     C A      L+F+ +  I ++ 
Sbjct: 398  DECQNP-GICSQICINLK-GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455

Query: 949  IDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTV-VVSSV 1007
            ++ ++    I  +  LRN  A+D D   ++L+W D  Q  I  A  D   G  V ++ +V
Sbjct: 456  LERKE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512

Query: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE 1067
                    P  +++D   + IYWT  A+  I+V  LDG     +   +   P ++ V+P 
Sbjct: 513  ------YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL 566

Query: 1068 KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIE 1127
             G++Y+++  E + KIE+A ++G +R  L  + +  P  + LD    +L+W DS L  + 
Sbjct: 567  SGFVYWSDWGEPA-KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625

Query: 1128 SSDLSGAN-RIVLEDSNIL-QPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQAR 1184
            S DL+G + RIVL+    L  P+ LT+FE+ +YWID + + +   +  TG E  T V   
Sbjct: 626  SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN-N 684

Query: 1185 IAQLSDIHAVKELNLQEYRQHPCAQD--NGGCSHICLVK---GDGTTR--CSCP 1231
            +    DI    EL +Q   ++ C +D  NGGC ++CL      D + +  CSCP
Sbjct: 685  LNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737



 Score =  115 bits (287), Expect = 4e-25
 Identities = 60/132 (45%), Positives = 75/132 (56%), Gaps = 13/132 (9%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NC---PV----CS 1289
            DEL C  PPTC   +F C T    CIP++W CD   +C D SDE    C   PV    C 
Sbjct: 184  DELDCA-PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240

Query: 1290 ESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348
             S+ QC SG+CI    RC+GD +C+D SDE NC    C  DQF C +G CI   ++C+  
Sbjct: 241  ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300

Query: 1349 VDCSDKSDELDC 1360
             DC D SDE++C
Sbjct: 301  RDCVDGSDEVNC 312



 Score =  108 bits (270), Expect = 4e-23
 Identities = 55/124 (44%), Positives = 71/124 (57%), Gaps = 11/124 (8%)

Query: 1243 CGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
            CG  P     C   +  C +GE  CI   WRCDG  +C+D SDE+NCP   C   QF+C 
Sbjct: 229  CGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL--CL-IDQFRCANGQCIGKHKKCDHNVDCSD 1353
             G CI G+ +CNG  +C D SDE NC+ +  CL   +F+C +G+CI   K C+   DC D
Sbjct: 287  DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346

Query: 1354 KSDE 1357
             SDE
Sbjct: 347  WSDE 350



 Score =  107 bits (268), Expect = 7e-23
 Identities = 62/159 (38%), Positives = 85/159 (53%), Gaps = 17/159 (10%)

Query: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRC 1270
            NG C  + L K DG   C      V   DE +C +  TC+   F C  G+  C+P  W+C
Sbjct: 42   NGRCITL-LWKCDGDEDC------VDGSDEKNCVKK-TCAESDFVCNNGQ--CVPSRWKC 91

Query: 1271 DGFTECEDHSDE----LNCPVCSESQFQCA--SGQCIDGALRCNGDANCQDKSDEKNC-E 1323
            DG  +CED SDE     +   C   +  C   S QCI  + RC+G+ +C    DE+NC  
Sbjct: 92   DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN 151

Query: 1324 VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362
            + C  D+F C++G+CI ++  C+   DCSD SDELDC P
Sbjct: 152  ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP 190



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 36/71 (50%), Positives = 44/71 (61%), Gaps = 1/71 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C  SQFQC +G+CI    +C+GD +C D SDEKNC +  C    F C NGQC+    KCD
Sbjct: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92

Query: 1347 HNVDCSDKSDE 1357
             + DC D SDE
Sbjct: 93   GDPDCEDGSDE 103



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 18/35 (51%), Positives = 22/35 (62%)

Query: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C   QF+C NG+CI    KCD + DC D SDE +C
Sbjct: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 6/53 (11%)

Query: 1199 LQEYRQHPCAQDNGGCSHIC--LVKGDGTTRCSCPMHLVLLQDELSCGEPPTC 1249
            L+E   + C  +NGGCSHIC  LV G     C C     L+ D  +CG+   C
Sbjct: 352  LKECHINECLVNNGGCSHICKDLVIG---YECDCAAGFELI-DRKTCGDIDEC 400


>gi|61744467 low density lipoprotein receptor-related protein 8
           isoform 3 precursor [Homo sapiens]
          Length = 700

 Score =  241 bits (615), Expect = 4e-63
 Identities = 137/401 (34%), Positives = 208/401 (51%), Gaps = 61/401 (15%)

Query: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPEAF--------- 633
           G N C   NGGCSH+C     G  C CP GF+L+      D+  C  P+A          
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266

Query: 634 ----------------------------LLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665
                                       L+F+ R ++RRI L   N +  IP+  +K   
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 324

Query: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721
           ALD +V  NRIYW D+S + I  A+M+ ++     E +++  L  PEG+AVDW+ K++YW
Sbjct: 325 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 384

Query: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
            D+G   I V+ +DG  R+ L  ++L  PRA+A+DP  GFMYW++WG + KI+++ ++G 
Sbjct: 385 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 444

Query: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837
           +R TLV  N+   NG+T+D   +RLYW D   + + S +  G NR+ +    D L HPFG
Sbjct: 445 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504

Query: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896
           +  ++D ++WTD    +I  AN+ +G   +I+  +L+   DI++FH  +Q    + C  S
Sbjct: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564

Query: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC 929
              NG C +LCL  P        + C CP    L  D + C
Sbjct: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605



 Score =  233 bits (593), Expect = 1e-60
 Identities = 120/322 (37%), Positives = 186/322 (57%), Gaps = 14/322 (4%)

Query: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
           +P L++ NR ++R +D    K N + ++  L++  A+D   +   IYW D+S   I    
Sbjct: 292 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 349

Query: 80  FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
            +K      Q V++   L SP+GLA DW+ + +YWTDS    I V+ +DG  R+ LF + 
Sbjct: 350 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 409

Query: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
           L +PRAIA+DP  GFMYW+DWG+  KIE++G++G  R  +++  I WPNG+TLD   Q+L
Sbjct: 410 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469

Query: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
           YW D+KL+ +   +  G NR+ ++  +  L HPF + +FED ++WTD    +I + N+  
Sbjct: 470 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 529

Query: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
           G  +  +  ++ +P DI  F + +QP A + C +    NGGC +LCL +P      P Y 
Sbjct: 530 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589

Query: 308 CACPTGVKLLENGKTCKDGATE 329
           CACP  + L  + K C   A E
Sbjct: 590 CACPDTMWLGPDMKRCYRDANE 611



 Score =  213 bits (541), Expect = 2e-54
 Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C  +NGGCSH+C  + +K  ++C CP G +LL+  KTC D                  
Sbjct: 209 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 265

Query: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
                                   G +  L+   R ++RRI L   +++ ++  L+++  
Sbjct: 266 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 323

Query: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNL 417
            +A+D +     IYW D   R I  +++D +      + ++  Q+  P+G+AVDWV +++
Sbjct: 324 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382

Query: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
           YWTD+G   I V  ++G  R+ L S +L EPRAI +DP+ G+MYW+DWG+  KIE++ L+
Sbjct: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442

Query: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
           G DR  LV+ ++ WPNG+ LD    ++YW D+K  ++  ++  G  R+ L+   D + H 
Sbjct: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 502

Query: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
           FG  +  D V+WTD +  +I   ++    E  ++ + L         N H ++       
Sbjct: 503 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 554

Query: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
               + C    + NGGC +LCL  PQ         CACP    L  DMK C
Sbjct: 555 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605



 Score =  139 bits (350), Expect = 2e-32
 Identities = 107/415 (25%), Positives = 179/415 (43%), Gaps = 76/415 (18%)

Query: 889  GWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC------------------- 929
            G NEC  +NG CSH+C  + +G F C CPA + L  D +TC                   
Sbjct: 207  GLNECLHNNGGCSHICTDLKIG-FECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNY 264

Query: 930  ------------------------SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
                                    +  +  L+F+ +  + R+ + ++    +I     L+
Sbjct: 265  KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLK 321

Query: 966  NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLS 1020
            NV A+D +    ++YW D     I  A  D +       S    Q + I      P  L+
Sbjct: 322  NVVALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLA 374

Query: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
            +D   ++IYWT      I+V  +DG     +       PRA+ V+P +G+MY+++  +++
Sbjct: 375  VDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA 434

Query: 1081 PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE 1140
             KIE++ L+G +R+ L    +  P  + LD    +L+W DS L ++ S D SG NR  L 
Sbjct: 435  -KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 493

Query: 1141 DSN--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELN 1198
             S   +  P G+ VFE+ ++W D +    E I    R    ++      L++ H +   +
Sbjct: 494  SSTDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFH 550

Query: 1199 LQEYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSC 1243
              +  + P A     Q NGGC ++CL     ++      C+CP  + L  D   C
Sbjct: 551  ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)

Query: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294
            D L  G+ P   C   QF C      CIP  WRCD   +C DHSDE +CP   C++S F 
Sbjct: 35   DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349
            C +G CI    +C+G+  C D SDE      + +C  ++  C   + +C+    +CD   
Sbjct: 93   CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152

Query: 1350 DCSDKSDELDC 1360
            DC   +DE  C
Sbjct: 153  DCEGGADEAGC 163



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 45/155 (29%), Positives = 64/155 (41%), Gaps = 21/155 (13%)

Query: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWR 1269
            DNG C H    K DG   C         + E +C +   C  ++ +C      C+P +WR
Sbjct: 94   DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147

Query: 1270 CDGFTECEDHSDELNCP----VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
            CDG  +CE  +DE  C      C   +FQC  G C+     CN + +C D SDE  C   
Sbjct: 148  CDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC--- 204

Query: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
                       +C+  +  C H   C+D     +C
Sbjct: 205  ------LQGLNECLHNNGGCSH--ICTDLKIGFEC 231



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C + QFQC + +CI    RC+ D +C D SDE +C +  C    F C NG CI +  KCD
Sbjct: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106

Query: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
               +C D SDE +   T++  P
Sbjct: 107  GEEECPDGSDESEATCTKQVCP 128



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 10/71 (14%)

Query: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
            C  +NGGCSHIC     G   C+CP    LL D+ +CG+   C             C  +
Sbjct: 211  CLHNNGGCSHICTDLKIG-FECTCPAGFQLL-DQKTCGDIDECKDPD--------ACSQI 260

Query: 1267 AWRCDGFTECE 1277
                 G+ +CE
Sbjct: 261  CVNYKGYFKCE 271


>gi|66082554 low density lipoprotein receptor-related protein 8
           isoform 2 precursor [Homo sapiens]
          Length = 793

 Score =  241 bits (615), Expect = 4e-63
 Identities = 142/426 (33%), Positives = 218/426 (51%), Gaps = 62/426 (14%)

Query: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPEAF----------- 633
           N C   NGGCSH+C     G  C CP GF+L+      D+  C  P+A            
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227

Query: 634 --------------------------LLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667
                                     L+F+ R ++RRI L   N +  IP+  +K   AL
Sbjct: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVVAL 285

Query: 668 DFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYWAD 723
           D +V  NRIYW D+S + I  A+M+ ++     E +++  L  PEG+AVDW+ K++YW D
Sbjct: 286 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 345

Query: 724 TGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSER 783
           +G   I V+ +DG  R+ L  ++L  PRA+A+DP  GFMYW++WG + KI+++ ++G +R
Sbjct: 346 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 405

Query: 784 TTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLT 839
            TLV  N+   NG+T+D   +RLYW D   + + S +  G NR+ +    D L HPFG+ 
Sbjct: 406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 465

Query: 840 QYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS-- 896
            ++D ++WTD    +I  AN+ +G   +I+  +L+   DI++FH  +Q    + C  S  
Sbjct: 466 VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 525

Query: 897 -NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRMVI 949
            NG C +LCL  P        + C CP    L  D + C  AP +    +  S + R V 
Sbjct: 526 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP 585

Query: 950 DEQQSP 955
              ++P
Sbjct: 586 ATTRAP 591



 Score =  231 bits (589), Expect = 4e-60
 Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)

Query: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
           +P L++ NR ++R +D    K N + ++  L++  A+D   +   IYW D+S   I    
Sbjct: 251 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 308

Query: 80  FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
            +K      Q V++   L SP+GLA DW+ + +YWTDS    I V+ +DG  R+ LF + 
Sbjct: 309 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 368

Query: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
           L +PRAIA+DP  GFMYW+DWG+  KIE++G++G  R  +++  I WPNG+TLD   Q+L
Sbjct: 369 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428

Query: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
           YW D+KL+ +   +  G NR+ ++  +  L HPF + +FED ++WTD    +I + N+  
Sbjct: 429 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 488

Query: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
           G  +  +  ++ +P DI  F + +QP A + C +    NGGC +LCL +P      P Y 
Sbjct: 489 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548

Query: 308 CACPTGVKLLENGKTC 323
           CACP  + L  + K C
Sbjct: 549 CACPDTMWLGPDMKRC 564



 Score =  213 bits (541), Expect = 2e-54
 Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)

Query: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
           N C  +NGGCSH+C  + +K  ++C CP G +LL+  KTC D                  
Sbjct: 168 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 224

Query: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
                                   G +  L+   R ++RRI L   +++ ++  L+++  
Sbjct: 225 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 282

Query: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGS----QFVVTAQIAHPDGIAVDWVARNL 417
            +A+D +     IYW D   R I  +++D +      + ++  Q+  P+G+AVDWV +++
Sbjct: 283 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341

Query: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
           YWTD+G   I V  ++G  R+ L S +L EPRAI +DP+ G+MYW+DWG+  KIE++ L+
Sbjct: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401

Query: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
           G DR  LV+ ++ WPNG+ LD    ++YW D+K  ++  ++  G  R+ L+   D + H 
Sbjct: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 461

Query: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
           FG  +  D V+WTD +  +I   ++    E  ++ + L         N H ++       
Sbjct: 462 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 513

Query: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
               + C    + NGGC +LCL  PQ         CACP    L  DMK C
Sbjct: 514 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564



 Score =  140 bits (353), Expect = 1e-32
 Identities = 116/456 (25%), Positives = 192/456 (42%), Gaps = 81/456 (17%)

Query: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC--------------------- 929
            NEC  +NG CSH+C  + +G F C CPA + L  D +TC                     
Sbjct: 168  NECLHNNGGCSHICTDLKIG-FECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKG 225

Query: 930  ----------------------SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
                                  +  +  L+F+ +  + R+ + ++    +I     L+NV
Sbjct: 226  YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLKNV 282

Query: 968  RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLSID 1022
             A+D +    ++YW D     I  A  D +       S    Q + I      P  L++D
Sbjct: 283  VALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLAVD 335

Query: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082
               ++IYWT      I+V  +DG     +       PRA+ V+P +G+MY+++  +++ K
Sbjct: 336  WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-K 394

Query: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142
            IE++ L+G +R+ L    +  P  + LD    +L+W DS L ++ S D SG NR  L  S
Sbjct: 395  IEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 454

Query: 1143 N--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
               +  P G+ VFE+ ++W D +    E I    R    ++      L++ H +   +  
Sbjct: 455  TDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511

Query: 1201 EYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPTCS 1250
            +  + P A     Q NGGC ++CL     ++      C+CP  + L  D   C   P  S
Sbjct: 512  KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-S 570

Query: 1251 PQQFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282
                T  +     +P   R  G T      ++HS E
Sbjct: 571  TSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 606



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)

Query: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294
            D L  G+ P   C   QF C      CIP  WRCD   +C DHSDE +CP   C++S F 
Sbjct: 35   DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92

Query: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349
            C +G CI    +C+G+  C D SDE      + +C  ++  C   + +C+    +CD   
Sbjct: 93   CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152

Query: 1350 DCSDKSDELDC 1360
            DC   +DE  C
Sbjct: 153  DCEGGADEAGC 163



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
            C + QFQC + +CI    RC+ D +C D SDE +C +  C    F C NG CI +  KCD
Sbjct: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106

Query: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
               +C D SDE +   T++  P
Sbjct: 107  GEEECPDGSDESEATCTKQVCP 128



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 6/76 (7%)

Query: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWR 1269
            DNG C H    K DG   C         + E +C +   C  ++ +C      C+P +WR
Sbjct: 94   DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147

Query: 1270 CDGFTECEDHSDELNC 1285
            CDG  +CE  +DE  C
Sbjct: 148  CDGEKDCEGGADEAGC 163


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
           sapiens]
          Length = 1207

 Score =  239 bits (610), Expect = 2e-62
 Identities = 130/353 (36%), Positives = 199/353 (56%), Gaps = 9/353 (2%)

Query: 289 DNGGCSHLCL-MSPVKPFYQCACPTGVKLLENGKTCK-DGATELLLLARRTDLRRISLDT 346
           DNGGCS LC+ +SPV   ++C C  G  L  + K+C   G    LL A   D+R +  D 
Sbjct: 443 DNGGCSQLCVPLSPVS--WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDG 500

Query: 347 PDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPD 406
            D+  ++ Q   +    A+D+DPVE  IY+    ++ I R+ +DGS  + ++   +  P+
Sbjct: 501 TDYGTLLSQ--QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558

Query: 407 GIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG 466
           G+AVDW+ R  YWTD G   I  + LNG   KI+  E++ +PR I + PM   ++WTD G
Sbjct: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTG 618

Query: 467 EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRV 526
             P+IE ++L G  R+V+ ++ L WP+G+ +D+   K+YW DAK   IE+ N DG+ RR 
Sbjct: 619 INPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678

Query: 527 LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRV 586
           L ++ + H F   +  DYV+++DW   S+ RV+KR+ +  V + Q   L       VH +
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRL-QGSMLKPSSLVVVHPL 737

Query: 587 I--GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFS 637
              G++PC  +NGGC H+C  R     C+C  GF   SD KTC+  +   L +
Sbjct: 738 AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLA 790



 Score =  220 bits (561), Expect = 8e-57
 Identities = 116/343 (33%), Positives = 195/343 (56%), Gaps = 9/343 (2%)

Query: 595 ENGGCSHLCL-YRPQGLRCACPIGFELISDMKTCIV--PEAFLLFSRRADIRRISLE-TN 650
           +NGGCS LC+   P    C C  G++L  D K+C    P+ FLLF+   DIR +  + T+
Sbjct: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502

Query: 651 NNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGM 710
              +     G+    ALD D  +N+IY+   +LK I RA M+GS  E ++E G+D PEG+
Sbjct: 503 YGTLLSQQMGM--VYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGL 560

Query: 711 AVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770
           AVDW+G+  YW D G + I  S L+G+  +++  +++  PR +A+ P    ++WT+ G  
Sbjct: 561 AVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGIN 620

Query: 771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLG-LNREVI 828
           P+I+ +++ G  R  +   ++   +G+TID+   +LYW D   ++IE +N+ G   R + 
Sbjct: 621 PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLT 680

Query: 829 ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQS 888
            +D+ HPF +  ++DY++++DW+  S+ R NK +G++R  +QG +     ++V H   + 
Sbjct: 681 QNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP 740

Query: 889 GWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA 931
           G + C   NG C H+C    +G   C C   +   +D +TC A
Sbjct: 741 GADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTCLA 782



 Score =  200 bits (508), Expect = 1e-50
 Identities = 104/327 (31%), Positives = 178/327 (54%), Gaps = 5/327 (1%)

Query: 14  CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
           C      P LL+AN +D+R +   +G +  T++   +    A+D       IY++  + +
Sbjct: 476 CAASGPQPFLLFANSQDIRHMHF-DGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK 534

Query: 74  AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF 133
            I+R   + ++  + ++  G+  P+GLA DW+G + YWTD   + I  S+L+G   K++ 
Sbjct: 535 WIERANMDGSQR-ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIIT 593

Query: 134 WQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEE 193
            + + QPR IA+ P +  ++WTD G  P+IE + + G  R +I +S++ WP+G+T+D+  
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLT 653

Query: 194 QKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
            KLYW DAK + I  +NLDG+ R+ + +  + HPFA+ +FED ++++DW+  S++  NK 
Sbjct: 654 DKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKR 713

Query: 254 TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTG 313
           TG+    +   +  P  +       +P A +PC   NGGC H+C       +  C+C  G
Sbjct: 714 TGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGGCEHICKKRLGTAW--CSCREG 770

Query: 314 VKLLENGKTCKDGATELLLLARRTDLR 340
                +GKTC       LL     DL+
Sbjct: 771 FMKASDGKTCLALDGHQLLAGGEVDLK 797



 Score =  172 bits (435), Expect = 3e-42
 Identities = 190/787 (24%), Positives = 310/787 (39%), Gaps = 165/787 (20%)

Query: 600  SHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLT 659
            S + L  PQ    +CP G    +   TC+ P  FL+FS    I RI  E  N    +   
Sbjct: 16   SFVSLSAPQ--HWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDA 73

Query: 660  GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNL 719
            GV  +  +DF   + RIYW D+  + + R F+NGS  E V     +   GMA++W+ + +
Sbjct: 74   GV--SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-SGMAINWINEEV 130

Query: 720  YWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYW-TEWGGKPKIDRAAM 778
             W++     I V+ + G +  +L+   L  P  +A+DP E F++W +E  G   + RA +
Sbjct: 131  IWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG--SLYRADL 187

Query: 779  DGSERTTLVPNVGRANGLTIDYAKRRLYWTDLD----TNLIESSNMLGLNREVIADDLPH 834
            DG     L+    +   +++D   +RL+W   +     +LI S +  G +  +      H
Sbjct: 188  DGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQH 247

Query: 835  P-FGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVM--DILVFH-----SSR 886
              F ++ + D I+++ W  ++I  ANK +G++   I  H  +V   ++ V H      + 
Sbjct: 248  NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAE 307

Query: 887  QSGWNE----CASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
               W      C    G+CS       +   +C C   Y+L+ D + C        ++   
Sbjct: 308  DDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC 367

Query: 943  AINRMVIDEQQSPD----------IILP----IHSL----RNVRAIDYD-------PL-- 975
             +       + +P           ++LP     H L    RNV    +D       PL  
Sbjct: 368  TLGC-----KNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCF 422

Query: 976  --DKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQP-YDLSIDIYSRYIYWTC 1032
              +  +   D +      + ++G      V  S  S   +  P YDL +D  S      C
Sbjct: 423  CPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKS------C 476

Query: 1033 EATNV-----------INVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSP 1081
             A+             I     DG   G +L  +     A+  +P +  +YF +   +  
Sbjct: 477  AASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK-- 534

Query: 1082 KIERAALDGTEREVLFFSGLSKPIALALD-------------SRLG-------------- 1114
             IERA +DG++RE L   G+  P  LA+D             S +G              
Sbjct: 535  WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITK 594

Query: 1115 ----------------KLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTV--FEN 1155
                            +LFW D+ +  RIESS L G  R+V+  S+++ P G+T+    +
Sbjct: 595  ENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTD 654

Query: 1156 WLYWIDKQQQMIEKIDMTG---------------------------------------RE 1176
             LYW D +Q +IE  ++ G                                       R 
Sbjct: 655  KLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRT 714

Query: 1177 GRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL 1236
            G+ +V+ + + L     V    L +    PC   NGGC HIC  K  GT  CSC    + 
Sbjct: 715  GKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMK 773

Query: 1237 LQDELSC 1243
              D  +C
Sbjct: 774  ASDGKTC 780



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 77/323 (23%), Positives = 152/323 (47%), Gaps = 28/323 (8%)

Query: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
           AP L++++   +  +D         +V  G+  +  +DF ++   IYW D+  + ++R  
Sbjct: 45  APFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNEKRIYWVDLERQLLQRVF 102

Query: 80  FNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
            N +   Q  V +   +  G+A +W+ E++ W++ +   I V+++ G+   +L    L  
Sbjct: 103 LNGSR--QERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKY 159

Query: 140 PRAIALDPSSGFMYWTDWGEVP-KIERAGMDGSS-RFIIINSEIYWPNGLTLDYEEQKLY 197
           P  +A+DP   F++W+   EV   + RA +DG   + ++  SE      ++LD  +++L+
Sbjct: 160 PANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLETSEKI--TAVSLDVLDKRLF 215

Query: 198 WA----DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
           W     +   + I   + DG +       +  + FA++LF D ++++ W   +I   NK+
Sbjct: 216 WIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275

Query: 254 TGEGLREI--HSDIFSPMD----IHAFSQQRQPNAT-----NPCGIDNGGCSHLCLMSPV 302
           TG+ +  I  HS  F P+     +H  +Q +  + T       C +  G CS       +
Sbjct: 276 TGKDMVRINLHSS-FVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334

Query: 303 KPFYQCACPTGVKLLENGKTCKD 325
           +  + C C  G  L  + K C+D
Sbjct: 335 QS-HLCMCAEGYALSRDRKYCED 356



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 81/338 (23%), Positives = 153/338 (45%), Gaps = 29/338 (8%)

Query: 309 ACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYD 368
           +CP G  L  NG +   G    L+ +    + RI  +  ++  +V+   D   ++ +D+ 
Sbjct: 27  SCPEGT-LAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFH 82

Query: 369 PVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIE 428
             E  IYW D E + ++R F++GS  + V   +  +  G+A++W+   + W++     I 
Sbjct: 83  YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIIT 141

Query: 429 VTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIP-KIERAALDGSDRVVLVNT 487
           VT + G    IL+S  L+ P  + +DP+  +++W+   E+   + RA LDG     L+ T
Sbjct: 142 VTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198

Query: 488 SLGWPNGLALDYDEGKIYW----GDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD 543
           S      ++LD  + +++W     +     I   + DG    +       ++F  +L GD
Sbjct: 199 S-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGD 257

Query: 544 YVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEEN------- 596
            ++++ W+ ++I   +K + +  V I+     + L    V   + + P AE++       
Sbjct: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPL-AQPKAEDDTWEPEQK 316

Query: 597 ------GGCSH-LCLYRPQGLRCACPIGFELISDMKTC 627
                 G CS  +C    Q   C C  G+ L  D K C
Sbjct: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 3/87 (3%)

Query: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
            C ++   CSH C++  +G   C CP   VL +D  +C      SP    C    +   PV
Sbjct: 401  CPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTCSG--CSSPDNGGCSQLCVPLSPV 457

Query: 1267 AWRCDGFTECEDHSDELNCPVCSESQF 1293
            +W CD F   +   DE +C       F
Sbjct: 458  SWECDCFPGYDLQLDEKSCAASGPQPF 484


>gi|4504975 low density lipoprotein receptor precursor [Homo
           sapiens]
          Length = 860

 Score =  230 bits (586), Expect = 1e-59
 Identities = 118/345 (34%), Positives = 191/345 (55%), Gaps = 15/345 (4%)

Query: 14  CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
           C  + +   L + NR ++R +  T  +   T ++  L +  A+D   +   IYWSD+S+ 
Sbjct: 392 CKAVGSIAYLFFTNRHEVRKM--TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR 449

Query: 74  AIKRTEFNKTESVQN---VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRK 130
            I  T+ ++   V +   V+   + +PDGLA DW+   +YWTDS    + V++  G  RK
Sbjct: 450 MICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRK 509

Query: 131 VLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLD 190
            LF +   +PRAI +DP  GFMYWTDWG   KI++ G++G   + ++   I WPNG+TLD
Sbjct: 510 TLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 569

Query: 191 YEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSIL 248
               +LYW D+KL+ I   +++G NR+ +++    L HPF+L +FED ++WTD    +I 
Sbjct: 570 LLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF 629

Query: 249 ACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC---GIDNGGCSHLCL----MSP 301
           + N+ TG  +  +  ++ SP D+  F    QP   N C    + NGGC +LCL    ++P
Sbjct: 630 SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINP 689

Query: 302 VKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDT 346
             P + CACP G+ L  + ++C   A E  +  + T   R+ + +
Sbjct: 690 HSPKFTCACPDGMLLARDMRSCLTEA-EAAVATQETSTVRLKVSS 733



 Score =  219 bits (558), Expect = 2e-56
 Identities = 130/420 (30%), Positives = 209/420 (49%), Gaps = 60/420 (14%)

Query: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPE----------- 631
           G+N C + NGGCSH+C     G  C CP GF+L++     D+  C  P+           
Sbjct: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG 373

Query: 632 -------------------------AFLLFSRRADIRRISLETNNNNVAIPLTGVKEASA 666
                                    A+L F+ R ++R+++L+ +     IP   ++   A
Sbjct: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIP--NLRNVVA 431

Query: 667 LDFDVTDNRIYWTDISLKTISRAFMNG----SALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
           LD +V  NRIYW+D+S + I    ++     S+ + V+   +  P+G+AVDW+  N+YW 
Sbjct: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491

Query: 723 DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSE 782
           D+    + V+   G  R+ L  ++   PRA+ +DP  GFMYWT+WG   KI +  ++G +
Sbjct: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551

Query: 783 RTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD---LPHPFGL 838
             +LV  N+   NG+T+D    RLYW D   + I S ++ G NR+ I +D   L HPF L
Sbjct: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611

Query: 839 TQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNEC---A 894
             ++D ++WTD    +I  AN+ +G +  ++  +L    D+++FH+  Q  G N C    
Sbjct: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTT 671

Query: 895 SSNGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI 949
            SNG C +LCL  P        F C CP    L  D R+C       + +Q+++  R+ +
Sbjct: 672 LSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKV 731



 Score =  217 bits (553), Expect = 6e-56
 Identities = 148/480 (30%), Positives = 229/480 (47%), Gaps = 74/480 (15%)

Query: 283 TNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKL------------------------LE 318
           TN C  +NGGCSH+C  + +K  Y+C CP G +L                        LE
Sbjct: 315 TNECLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLE 372

Query: 319 NG---------------KTCKD-GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
            G               K CK  G+   L    R ++R+++LD  ++T ++    ++R+ 
Sbjct: 373 GGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI---PNLRNV 429

Query: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDG----SGSQFVVTAQIAHPDGIAVDWVARNLY 418
           +A+D +     IYW+D   R I  + +D     S    V++  I  PDG+AVDW+  N+Y
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489

Query: 419 WTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDG 478
           WTD+    + V    G  RK L  E+  +PRAIV+DP+ G+MYWTDWG   KI++  L+G
Sbjct: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549

Query: 479 SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVED--KIPHIF 536
            D   LV  ++ WPNG+ LD   G++YW D+K   I  ++ +G  R+ ++ED  ++ H F
Sbjct: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609

Query: 537 GFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQL--PDLMGLKATNVHRVIGSNPCA 593
              +  D V+WTD    +I   ++   ++  ++ + L  P+ M L   N+ +  G N C 
Sbjct: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL-FHNLTQPRGVNWCE 668

Query: 594 E---ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRR 644
                NGGC +LCL  PQ         CACP G  L  DM++C+           A+   
Sbjct: 669 RTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLT---------EAEAAV 719

Query: 645 ISLETNNNNVAIPLTGVKEASALDFDVTD-NRIYWTDISLKTISRAFMNGSALEHVVEFG 703
            + ET+   + +  T V+        V D +R+      L T+    M+  AL  V   G
Sbjct: 720 ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRG 779



 Score =  144 bits (362), Expect = 9e-34
 Identities = 108/410 (26%), Positives = 180/410 (43%), Gaps = 61/410 (14%)

Query: 886  RQSGWNECASSNGHCSHLCLAVPVG----------------------------------- 910
            ++ G NEC  +NG CSH+C  + +G                                   
Sbjct: 311  KECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN 370

Query: 911  ---GFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
               G+ C C   + L+   + C A     +L F+ +  + +M +D  +   +I    +LR
Sbjct: 371  LEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI---PNLR 427

Query: 966  NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS 1025
            NV A+D +    ++YW D  Q MI   Q D + G +    +V S++++  P  L++D   
Sbjct: 428  NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQA-PDGLAVDWIH 485

Query: 1026 RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIER 1085
              IYWT      ++V    G     + +    +PRA+VV+P  G+MY+T+    + KI++
Sbjct: 486  SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA-KIKK 544

Query: 1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR--IVLEDSN 1143
              L+G +   L    +  P  + LD   G+L+W DS L  I S D++G NR  I+ ++  
Sbjct: 545  GGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKR 604

Query: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQARIAQLSDIHAVKELNLQEY 1202
            +  P  L VFE+ ++W D   + I   + +TG +     +     LS    V   NL + 
Sbjct: 605  LAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAE---NLLSPEDMVLFHNLTQP 661

Query: 1203 RQ----HPCAQDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSC 1243
            R           NGGC ++CL             C+CP  ++L +D  SC
Sbjct: 662  RGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711



 Score =  114 bits (286), Expect = 6e-25
 Identities = 64/171 (37%), Positives = 83/171 (48%), Gaps = 37/171 (21%)

Query: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID 1262
            RQ  C  D       CL   DG+   SCP+               TC P  F C +    
Sbjct: 124  RQFVCDSDRD-----CL---DGSDEASCPVL--------------TCGPASFQCNSST-- 159

Query: 1263 CIPVAWRCDGFTECEDHSDEL------------NCPVCSESQFQCASGQCIDGALRCNGD 1310
            CIP  W CD   +CED SDE             +   CS  +F C SG+CI  + RC+G 
Sbjct: 160  CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGG 219

Query: 1311 ANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
             +C+DKSDE+NC V  C  D+F+C++G CI   ++CD   DC D SDE+ C
Sbjct: 220  PDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270



 Score =  105 bits (262), Expect = 4e-22
 Identities = 51/119 (42%), Positives = 72/119 (60%), Gaps = 7/119 (5%)

Query: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCI 1301
            G+   CS  +F C +GE  CI  +WRCDG  +C+D SDE NC V  C   +FQC+ G CI
Sbjct: 192  GDSSPCSAFEFHCLSGE--CIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCI 249

Query: 1302 DGALRCNGDANCQDKSDEKNCEVLCLID---QFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
             G+ +C+ + +C+D SDE  C  + L +   +F+C +G+CI   K C+   DC D SDE
Sbjct: 250  HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308



 Score =  100 bits (250), Expect = 9e-21
 Identities = 48/113 (42%), Positives = 64/113 (56%), Gaps = 3/113 (2%)

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCASGQCIDGAL 1305
            TC    F+C      CIP  WRCDG  +C++ SDE  CP   CS+ +F+C  G+CI    
Sbjct: 67   TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQF 126

Query: 1306 RCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
             C+ D +C D SDE +C VL C    F+C +  CI +   CD++ DC D SDE
Sbjct: 127  VCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 46/119 (38%), Positives = 59/119 (49%), Gaps = 9/119 (7%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN----CPVCSESQFQCAS--GQCID 1302
            C   +F C  G+  CI   W CDG  EC+D SDE         C    F C     +CI 
Sbjct: 27   CERNEFQCQDGK--CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84

Query: 1303 GALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
               RC+G  +C + SDE+ C    C  D+FRC +G+CI +   CD + DC D SDE  C
Sbjct: 85   QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 32/80 (40%), Positives = 40/80 (50%), Gaps = 5/80 (6%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKN---CEVLCLIDQFRCAN--GQCIGKH 1342
            C  ++FQC  G+CI     C+G A CQD SDE       V C    F C     +CI + 
Sbjct: 27   CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86

Query: 1343 KKCDHNVDCSDKSDELDCYP 1362
             +CD  VDC + SDE  C P
Sbjct: 87   WRCDGQVDCDNGSDEQGCPP 106



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)

Query: 1199 LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLL-----QDELSCGEPPTCS 1250
            ++E   + C  +NGGCSH+C     G   C CP    L+     +D   C +P TCS
Sbjct: 310  IKECGTNECLDNNGGCSHVCNDLKIG-YECLCPDGFQLVAQRRCEDIDECQDPDTCS 365


>gi|4507157 sortilin-related receptor containing LDLR class A repeats
            preproprotein [Homo sapiens]
          Length = 2214

 Score =  204 bits (520), Expect = 4e-52
 Identities = 124/319 (38%), Positives = 171/319 (53%), Gaps = 29/319 (9%)

Query: 633  FLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMN 692
            F+L++ R  I R  L +      +PLTG++ A ALDFD   N +YW+D++L  I R  +N
Sbjct: 760  FILYAVRKSIYRYDLASGATE-QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLN 818

Query: 693  GSA-LEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKD-LDSP 750
            GS   E ++  GL+  E +A + L + LYW D G  +IEV+  DG  R  +V    LD P
Sbjct: 819  GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRP 878

Query: 751  RALALDPAEGFMYWTEWGG-KPKIDRAAMDGSERTTLVP-NVGRANGLTIDYAKRRLYWT 808
            RAL L P EG M+WT+WG  KP I R+ MDGS    LV  +V   NG+++D   + +YWT
Sbjct: 879  RALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWT 936

Query: 809  DLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTI 868
            D     IE     G  R VI D+LPHP+ +  +++ IYW DWS+ SI RA+K SG    I
Sbjct: 937  DAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEI 996

Query: 869  IQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCL------------------AVPVG 910
            +   L  +MD+ +F+  + +G N C      CS LCL                   +P G
Sbjct: 997  LANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDVSSSVLPSG 1054

Query: 911  GFVCGCPAHYSLNADNRTC 929
              +C CP  Y L   N TC
Sbjct: 1055 DLMCDCPQGYQLK--NNTC 1071



 Score =  189 bits (481), Expect = 1e-47
 Identities = 110/326 (33%), Positives = 177/326 (54%), Gaps = 22/326 (6%)

Query: 14   CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
            C L      +LYA R+ +   D  +G     + + GL  A A+DF + H  +YWSD++ +
Sbjct: 752  CPLAEENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSDLALD 810

Query: 74   AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLR-KVL 132
             I+R   N +   + ++ SGL + + LA + L + LYW D+   +IEV+N DG  R  ++
Sbjct: 811  VIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870

Query: 133  FWQELDQPRAIALDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
                LD+PRA+ L P  G M+WTDWG++ P I R+ MDGS+ + +++ ++ WPNG+++D 
Sbjct: 871  NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929

Query: 192  EEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACN 251
             +Q +YW DA L  I +    G  R +V+  +LPHP+A+ +F++ +YW DWS  SI   +
Sbjct: 930  -DQWIYWTDAYLECIERITFSGQQR-SVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987

Query: 252  KYTGEGLREIHSDIFSPMDIHAFSQQRQPNAT----NPCGI-----DNGGCSHLC---LM 299
            KY+G  +  + + +   MD+  F + +   +      PC +      N   S  C   + 
Sbjct: 988  KYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVS 1047

Query: 300  SPVKPF--YQCACPTGVKLLENGKTC 323
            S V P     C CP G +L  N  TC
Sbjct: 1048 SSVLPSGDLMCDCPQGYQLKNN--TC 1071



 Score =  184 bits (466), Expect = 8e-46
 Identities = 136/450 (30%), Positives = 220/450 (48%), Gaps = 41/450 (9%)

Query: 935  FLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQE 994
            F+L++ + +I R  +    +    LP+  LR   A+D+D     LYW D   ++I++   
Sbjct: 760  FILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817

Query: 995  DGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR-SVGVVLK 1053
            +GS G  V+++S     LE     L+ +  S+ +YW       I V   DG   + +V  
Sbjct: 818  NGSTGQEVIINS----GLETVEA-LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872

Query: 1054 GEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRL 1113
               DRPRA+V+ P++G M++T+  +  P I R+ +DG+    L    +  P  +++D + 
Sbjct: 873  SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQW 932

Query: 1114 GKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMT 1173
              ++W D+ L  IE    SG  R V+ D N+  P  + VF+N +YW D  Q  I +    
Sbjct: 933  --IYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFR---A 986

Query: 1174 GREGRTKVQARIAQLSDIHAVKEL-NLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPM 1232
             +   ++++    QL+ +  +K     +    + C      CS +CL K + +  C CP 
Sbjct: 987  SKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVP--RPCSLLCLPKANNSRSCRCPE 1044

Query: 1233 HL---VLLQDELSCG--------------EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTE 1275
             +   VL   +L C               E  TC   Q+ C  G  +CI   W CD   +
Sbjct: 1045 DVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNG--NCINSIWWCDFDND 1102

Query: 1276 CEDHSDELNCP--VCS-ESQFQC-ASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQ 1330
            C D SDE NCP  +C  ++QF+C  SG CI  + +C+ + +C D SDE +CE+  C  D+
Sbjct: 1103 CGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDE 1162

Query: 1331 FRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            + C++G CI     CD + DC D SDE +C
Sbjct: 1163 YNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192



 Score =  166 bits (420), Expect = 2e-40
 Identities = 103/312 (33%), Positives = 168/312 (53%), Gaps = 18/312 (5%)

Query: 329  ELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSF 388
            E +L A R  + R  L +       L L  +R A+A+D+D     +YW+D  +  I+R  
Sbjct: 759  EFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC 816

Query: 389  IDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISED-LE 446
            ++GS G + ++ + +   + +A + +++ LYW D G  +IEV   +G  R  +++   L+
Sbjct: 817  LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876

Query: 447  EPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIY 505
             PRA+VL P  G M+WTDWG++ P I R+ +DGS    LV+  + WPNG+++  D+  IY
Sbjct: 877  RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISV--DDQWIY 934

Query: 506  WGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AE 564
            W DA  + IE +   G  R V++ D +PH +   +  + +YW DW + SI R  K S ++
Sbjct: 935  WTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQ 993

Query: 565  REVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLR-CACPIGFELISD 623
             E++ +QL  LM +K     +  GSN C      CS LCL +    R C CP       D
Sbjct: 994  MEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCP------ED 1045

Query: 624  MKTCIVPEAFLL 635
            + + ++P   L+
Sbjct: 1046 VSSSVLPSGDLM 1057



 Score =  135 bits (341), Expect = 2e-31
 Identities = 136/486 (27%), Positives = 197/486 (40%), Gaps = 91/486 (18%)

Query: 944  INRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVV 1003
            I R+ ++     ++I+    L  V A+ ++PL + LYW+D+    I  A  DG    T+V
Sbjct: 812  IQRLCLNGSTGQEVIIN-SGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870

Query: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTC--EATNVINVTRLDGRSVGVVLKGEQDRPRA 1061
             SSV  +     P  L +      ++WT   +    I  + +DG +   ++  +   P  
Sbjct: 871  NSSVLDR-----PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNG 925

Query: 1062 VVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWAD- 1120
            + V+ +  ++Y+T+       IER    G +R V+    L  P A+A+     +++W D 
Sbjct: 926  ISVDDQ--WIYWTDAYLEC--IERITFSGQQRSVIL-DNLPHPYAIAVFKN--EIYWDDW 978

Query: 1121 SDLRRIESSDLSG------ANRIV-LEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMT 1173
            S L    +S  SG      AN++  L D  I    G     N           + K +  
Sbjct: 979  SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK-GKNTGSNACVPRPCSLLCLPKAN-N 1036

Query: 1174 GREGRTKVQARIA---------------QLSDIHAVKELNLQEYRQHPCAQDNGGC---- 1214
             R  R       +               QL +   VKE N     Q+ C+  NG C    
Sbjct: 1037 SRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCS--NGNCINSI 1094

Query: 1215 -----SHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSP------------------ 1251
                  + C   GD +   +CP  +  L  +  C E  TC P                  
Sbjct: 1095 WWCDFDNDC---GDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDES 1151

Query: 1252 ---------QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASG 1298
                      ++ C +G   CI  +W CDG  +C D SDE NC      C  S FQC +G
Sbjct: 1152 HCEMHQCRSDEYNCSSGM--CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG 1209

Query: 1299 QCIDGALRCNGDANCQDKSDEK--NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
             CI     C+GD +CQD SDE   NCE  C  + FRC NG CI   K CD   DCSD SD
Sbjct: 1210 HCIPQRWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSD 1267

Query: 1357 ELDCYP 1362
            E  C P
Sbjct: 1268 EQHCEP 1273



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 53/153 (34%), Positives = 75/153 (49%), Gaps = 33/153 (21%)

Query: 1239 DELSCGE----------PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV- 1287
            DE  CG+          P TC P  + C +G   C+   W CDG+ +C D SDE  CP+ 
Sbjct: 1399 DEKDCGDSHILPFSTPGPSTCLPNYYRCSSGT--CVMDTWVCDGYRDCADGSDEEACPLL 1456

Query: 1288 --------------CSESQFQCASGQ-CIDGALRCNGDANCQDKSDEKNCE----VLCLI 1328
                          C   +F+C   + CI    RC+G  +CQD  DE NC     + C+ 
Sbjct: 1457 ANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMS 1516

Query: 1329 DQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDC 1360
             +F+C +G+ CI   ++CD  +DCSD+SDE  C
Sbjct: 1517 REFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 59/162 (36%), Positives = 74/162 (45%), Gaps = 18/162 (11%)

Query: 1205 HPCAQDNGGCSHICLVKG----DGTTRCSCPMHLVLLQDELSCGEP-PTCSPQQFTCFTG 1259
            H C  D   CS    ++     DG   C          DE +C     TC    F C  G
Sbjct: 1156 HQCRSDEYNCSSGMCIRSSWVCDGDNDCRD------WSDEANCTAIYHTCEASNFQCRNG 1209

Query: 1260 EIDCIPVAWRCDGFTECEDHSDE--LNCPVCSESQFQCASGQCIDGALRCNGDANCQDKS 1317
               CIP  W CDG T+C+D SDE  +NC       F+C +G CI  +  C+G  +C D S
Sbjct: 1210 H--CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-FRCPNGTCIPSSKHCDGLRDCSDGS 1266

Query: 1318 DEKNCEVLCL-IDQFRCAN-GQCIGKHKKCDHNVDCSDKSDE 1357
            DE++CE LC     F C N  QC+     CD  + C D SDE
Sbjct: 1267 DEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 58/152 (38%), Positives = 66/152 (43%), Gaps = 24/152 (15%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCP-------V 1287
            DE  C EP       F C   +  C+  +  CDG  +C D SDE      C        V
Sbjct: 1267 DEQHC-EPLCTHFMDFVCKNRQ-QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKV 1324

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV------LCLIDQFRCANGQCIGK 1341
            C E  FQC +G CI    +C+G  +C D SDE NCE            QFRC NG CI  
Sbjct: 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPN 1384

Query: 1342 HKKCDHNVDCSDKSDELDC-----YPTEEPAP 1368
              KCD   DC D SDE DC      P   P P
Sbjct: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGP 1416



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 58/182 (31%), Positives = 78/182 (42%), Gaps = 41/182 (22%)

Query: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP---PTCSPQ-QFTCFTGEIDCIPV 1266
            NG C  + + K DG   C          DE +C  P   P CS   QF C  G   CIP 
Sbjct: 1334 NGVCISL-IWKCDGMDDCGD------YSDEANCENPTEAPNCSRYFQFRCENGH--CIPN 1384

Query: 1267 AWRCDGFTECEDHSDELNC-------------PVCSESQFQCASGQCIDGALRCNGDANC 1313
             W+CD   +C D SDE +C               C  + ++C+SG C+     C+G  +C
Sbjct: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444

Query: 1314 QDKSDEKNCEVL--------------CLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDEL 1358
             D SDE+ C +L              C   +F C   + CI   K+CD + DC D  DE 
Sbjct: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504

Query: 1359 DC 1360
            +C
Sbjct: 1505 NC 1506



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 41/110 (37%), Positives = 55/110 (50%), Gaps = 16/110 (14%)

Query: 1223 DGTTRCSCPMHLVLLQDELSCGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECED 1278
            DG+   +CP     L   ++    PT    C   +F C   +  CIP   RCDG  +C+D
Sbjct: 1446 DGSDEEACP-----LLANVTAASTPTQLGRCDRFEFECHQPKT-CIPNWKRCDGHQDCQD 1499

Query: 1279 HSDELNCP-----VCSESQFQCASGQ-CIDGALRCNGDANCQDKSDEKNC 1322
              DE NCP      C   +FQC  G+ CI  + RC+G  +C D+SDEK C
Sbjct: 1500 GRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score =  189 bits (481), Expect = 1e-47
 Identities = 110/295 (37%), Positives = 151/295 (51%), Gaps = 8/295 (2%)

Query: 630  PEAFLLFSRRADIRRISLETNNNNV----AIPLTGVKEASALDFDVTDNRIYWTDISLKT 685
            P   LLF++   I R+ LE N        A      K    L FD  D  +YWTDI+  +
Sbjct: 942  PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001

Query: 686  ISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWK 745
            I RA ++G     ++   L  PEG+AVD LG+N++W D+  +RIEV+KLDG  R+VL   
Sbjct: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061

Query: 746  DLDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR 803
            DL +PR +  D   G +YWT+W    PKI+ + MDG+ R  LV  ++G  NGLT D    
Sbjct: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121

Query: 804  RLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSG 863
            +L W D  TN  E  N    +R    + L +PF +T Y   +Y+TDW   S+   +    
Sbjct: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181

Query: 864  QNRTIIQGHLD-YVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
            +     Q H    +  I    S    G N C+ +NG C+HLCLA P G   C CP
Sbjct: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCP 1235



 Score =  182 bits (462), Expect = 2e-45
 Identities = 113/331 (34%), Positives = 168/331 (50%), Gaps = 16/331 (4%)

Query: 292  GCSHLCLMSPVKPFYQC-ACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLD--TPD 348
            G +  CL +   P +Q  A PT V  L  G          LL A+   + R+ L+  T  
Sbjct: 914  GMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTH--------LLFAQTGKIERLPLEGNTMR 965

Query: 349  FTDIVLQLE-DIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDG 407
             T+    L    +  I + +D V+  +YWTD    +I R+ + G     ++   +  P+G
Sbjct: 966  KTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEG 1025

Query: 408  IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG- 466
            IAVD + RN++WTD+  DRIEV +L+GT R++L   DL  PR IV D + G +YWTDW  
Sbjct: 1026 IAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNR 1085

Query: 467  EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRV 526
            + PKIE + +DG++R +LV   LG PNGL  D    ++ W DA T++ E +N     RR 
Sbjct: 1086 DNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRK 1145

Query: 527  LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID--QLPDLMGLKATNVH 584
             +E  + + F  T  G  +Y+TDW+  S+  +    ++        +   L G+      
Sbjct: 1146 ALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204

Query: 585  RVIGSNPCAEENGGCSHLCLYRPQGLRCACP 615
               G N C+  NGGC+HLCL  P    C CP
Sbjct: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235



 Score =  171 bits (432), Expect = 7e-42
 Identities = 97/256 (37%), Positives = 143/256 (55%), Gaps = 19/256 (7%)

Query: 64   LIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSN 123
            ++YW+D++E +I R   +  E    ++   L SP+G+A D LG  ++WTDS  +RIEV+ 
Sbjct: 991  MVYWTDITEPSIGRASLHGGEPT-TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049

Query: 124  LDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EVPKIERAGMDGSSRFIIINSEIY 182
            LDG+ R+VLF  +L  PR I  D   G +YWTDW  + PKIE + MDG++R I++  ++ 
Sbjct: 1050 LDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109

Query: 183  WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
             PNGLT D    +L W DA  N     N    +R+  ++G L +PFA+T +   LY+TDW
Sbjct: 1110 LPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDW 1168

Query: 243  STHSILACNKYTGEGLREIHSDIFSPMD-------IHAFSQQRQPNATNPCGIDNGGCSH 295
              +S++A +    +      +D F P           A SQ   P   N C ++NGGC+H
Sbjct: 1169 KMNSVVALDLAISK-----ETDAFQPHKQTRLYGITTALSQ--CPQGHNYCSVNNGGCTH 1221

Query: 296  LCLMSPVKPFYQCACP 311
            LCL +P      C CP
Sbjct: 1222 LCLATPGS--RTCRCP 1235



 Score =  114 bits (284), Expect = 1e-24
 Identities = 81/305 (26%), Positives = 144/305 (47%), Gaps = 16/305 (5%)

Query: 932  PTTFLLFSQKSAINRMVID--EQQSPDIILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNM 988
            P T LLF+Q   I R+ ++    +  +    +H   + +  + +D +DK +YW D  +  
Sbjct: 942  PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001

Query: 989  IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
            I +A   G +  T++   + S      P  +++D   R I+WT    + I V +LDG   
Sbjct: 1002 IGRASLHGGEPTTIIRQDLGS------PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055

Query: 1049 GVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
             V+ + +   PR +V +  +G +Y+T+    +PKIE + +DGT R +L    L  P  L 
Sbjct: 1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLT 1115

Query: 1109 LDSRLGKLFWADSDLRRIESSDLS-GANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMI 1167
             D+   +L W D+   R E  + S  + R  LE   +  P  +T +   LY+ D +   +
Sbjct: 1116 FDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGKNLYFTDWKMNSV 1173

Query: 1168 EKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHP-CAQDNGGCSHICLVKGDGTT 1226
              +D+   +     Q    + + ++ +     Q  + H  C+ +NGGC+H+CL    G+ 
Sbjct: 1174 VALDLAISKETDAFQPH--KQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSR 1230

Query: 1227 RCSCP 1231
             C CP
Sbjct: 1231 TCRCP 1235


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score =  176 bits (447), Expect = 1e-43
 Identities = 91/222 (40%), Positives = 135/222 (60%), Gaps = 5/222 (2%)

Query: 363  IAIDYDPVEGYIYWTDDEVRAIRRSFID-GSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
            + IDYD  E  +YWTD   R I R+ ++ G+  + +V + +  P+G+A+D + R +YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204

Query: 422  TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG-EIPKIERAALDGSD 480
            +  D+IE   L+G+ RK+L   DL  PRAI +DP+ G +YWTDW  E PKIE ++LDG +
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264

Query: 481  RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL 540
            R +L+NT +G PNGL  D     + W DA T K+E    DGTGRRV +++ + + F    
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIVS 1323

Query: 541  LGDYVYWTDWQRRSIERVHKRSAE--REVIIDQLPDLMGLKA 580
              D+ Y TDW+R  +  V+K S +   E + +Q   L G+ A
Sbjct: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITA 1365



 Score =  173 bits (439), Expect = 1e-42
 Identities = 89/216 (41%), Positives = 134/216 (62%), Gaps = 9/216 (4%)

Query: 42   NATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLA 101
            + +I+VG       +D+     ++YW+DV+   I R         + +V SGL+SP+GLA
Sbjct: 1140 HGSIIVG-------IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLA 1192

Query: 102  CDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EV 160
             D +   +YWTDS  ++IE + LDGS RKVLF+ +L  PRAIA+DP  G +YWTDW  E 
Sbjct: 1193 IDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREA 1252

Query: 161  PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVV 220
            PKIE + +DG +R I+IN++I  PNGLT D   + L WADA    +  +  DGT R+ V+
Sbjct: 1253 PKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VI 1311

Query: 221  KGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGE 256
            + +L +PF++  + D  Y TDW    +++ NK++G+
Sbjct: 1312 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347



 Score =  167 bits (424), Expect = 6e-41
 Identities = 82/201 (40%), Positives = 125/201 (62%), Gaps = 3/201 (1%)

Query: 667  LDFDVTDNRIYWTDISLKTISRAFMN-GSALEHVVEFGLDYPEGMAVDWLGKNLYWADTG 725
            +D+D  +  +YWTD++ +TISRA +  G+  E +V  GL  PEG+A+D + + +YW D+ 
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206

Query: 726  TNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK-PKIDRAAMDGSERT 784
             ++IE + LDG  R+VL + DL +PRA+A+DP  G +YWT+W  + PKI+ +++DG  R 
Sbjct: 1207 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1266

Query: 785  TLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQD 843
             L+  ++G  NGLT D   + L W D  T  +E +   G  R VI ++L +PF +  Y D
Sbjct: 1267 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYAD 1326

Query: 844  YIYWTDWSRRSIERANKTSGQ 864
            + Y TDW R  +   NK SGQ
Sbjct: 1327 HFYHTDWRRDGVVSVNKHSGQ 1347



 Score =  102 bits (253), Expect = 4e-21
 Identities = 69/243 (28%), Positives = 121/243 (49%), Gaps = 13/243 (5%)

Query: 934  TFLLFSQKSAINRMVID----EQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI 989
            TFLL++Q   I  + ++    ++ +   +L +H    V  IDYD  ++ +YW D     I
Sbjct: 1108 TFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIV-GIDYDCRERMVYWTDVAGRTI 1166

Query: 990  RKAQ-EDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
             +A  E G++  T+V S +      I P  L+ID   R +YWT    + I    LDG   
Sbjct: 1167 SRAGLELGAEPETIVNSGL------ISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSER 1220

Query: 1049 GVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
             V+   +   PRA+ V+P +G +Y+T+    +PKIE ++LDG  R +L  + +  P  L 
Sbjct: 1221 KVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLT 1280

Query: 1109 LDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
             D     L WAD+  +++E +   G  R V++ +N+  P  +  + +  Y  D ++  + 
Sbjct: 1281 FDPFSKLLCWADAGTKKLECTLPDGTGRRVIQ-NNLKYPFSIVSYADHFYHTDWRRDGVV 1339

Query: 1169 KID 1171
             ++
Sbjct: 1340 SVN 1342



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 40/115 (34%), Positives = 61/115 (53%), Gaps = 5/115 (4%)

Query: 353  VLQLEDIRHAIAIDYDPVEGYIYWTD--DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
            VL   D+ +  AI  DP+ G +YWTD   E   I  S +DG   + ++   I  P+G+  
Sbjct: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281

Query: 411  DWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465
            D  ++ L W D GT ++E T  +GT R++ I  +L+ P +IV      + Y TDW
Sbjct: 1282 DPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIV--SYADHFYHTDW 1333



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 4/121 (3%)

Query: 38   NGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIK-RTEFNKTESVQNVVVSGLLS 96
            +G E   +    L +  A+      G +YW+D + EA K  T     E+ + ++ + +  
Sbjct: 1216 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1275

Query: 97   PDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTD 156
            P+GL  D   + L W D+ T ++E +  DG+ R+V+    L  P +I     +   Y TD
Sbjct: 1276 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIV--SYADHFYHTD 1332

Query: 157  W 157
            W
Sbjct: 1333 W 1333



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 2/45 (4%)

Query: 587 IGSNPCAEENGGC--SHLCLYRPQGLRCACPIGFELISDMKTCIV 629
           +  N CA     C  + +C+  P   RC C  G+E   D  TCI+
Sbjct: 800 VDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCIL 844



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 4/68 (5%)

Query: 795  GLTIDYAKRRLYWTDLDTNLIESSNM-LGLNREVIADD---LPHPFGLTQYQDYIYWTDW 850
            G+  D  +R +YWTD+    I  + + LG   E I +     P    +   +  +YWTD 
Sbjct: 1146 GIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDS 1205

Query: 851  SRRSIERA 858
                IE A
Sbjct: 1206 VLDKIESA 1213


>gi|28557796 low density lipoprotein receptor class A domain
            containing 3 [Homo sapiens]
          Length = 345

 Score =  110 bits (276), Expect = 8e-24
 Identities = 57/124 (45%), Positives = 68/124 (54%), Gaps = 10/124 (8%)

Query: 1251 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASG-QCIDGAL 1305
            P  F C  G   CIP AW+CDG  +C D SDE  CP     C  + F CASG  CI G  
Sbjct: 32   PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89

Query: 1306 RCNGDANCQDKSDEKNCE---VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362
            RCNG  +C D SDE+NC    +LC   ++ C NG CI K   CD   +C D SDE  C  
Sbjct: 90   RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149

Query: 1363 TEEP 1366
            ++EP
Sbjct: 150  SQEP 153



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 40/90 (44%), Positives = 55/90 (61%), Gaps = 6/90 (6%)

Query: 1239 DELSCGEPPT-CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQF 1293
            DE  C +  + C P  F C +G I CI   +RC+GF +C D SDE NC     +CS +++
Sbjct: 60   DEKECPKAKSKCGPTFFPCASG-IHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARY 118

Query: 1294 QCASGQCIDGALRCNGDANCQDKSDEKNCE 1323
             C +G CID +  C+G  NCQD SDE++CE
Sbjct: 119  HCKNGLCIDKSFICDGQNNCQDNSDEESCE 148


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  109 bits (273), Expect = 2e-23
 Identities = 55/132 (41%), Positives = 71/132 (53%), Gaps = 11/132 (8%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC---PVCSESQFQCASGQCID 1302
            P  C PQ+  C  G   CIP  + CDG  +CED SDEL+C   P C  ++F C +G C  
Sbjct: 282  PLPCGPQEAACRNGH--CIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCAL 339

Query: 1303 GALRCNGDANCQDKSDEKNC-----EVLCLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSD 1356
               RC+GD +C+D++DE NC     E +C   QFRC +   CI     CD   DC D+SD
Sbjct: 340  KLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSD 399

Query: 1357 ELDCYPTEEPAP 1368
            E  C P +   P
Sbjct: 400  EFGCMPPQVVTP 411



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 52/142 (36%), Positives = 67/142 (47%), Gaps = 19/142 (13%)

Query: 1192 HAVKELNLQEYRQHPCAQDNGGCSH-ICLVKG---DGTTRCSCPMHLVLLQDELSCGEPP 1247
            HA + L     R  PC      C +  C+ +    DG   C          DEL CG PP
Sbjct: 270  HAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG------SDELDCGPPP 323

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP------VCSESQFQCAS-GQC 1300
             C P +F C  G   C    WRCDG  +CED +DE NCP      VC  +QF+C S   C
Sbjct: 324  PCEPNEFPCGNGH--CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMC 381

Query: 1301 IDGALRCNGDANCQDKSDEKNC 1322
            I  +  C+ +++C D+SDE  C
Sbjct: 382  IPASFHCDEESDCPDRSDEFGC 403



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 49/171 (28%), Positives = 71/171 (41%), Gaps = 52/171 (30%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PV---------------- 1287
            P  C+  +F C +   +C+ + +RCD   +C D SDELNC  PV                
Sbjct: 196  PRACTEAEFACHSYN-ECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSL 254

Query: 1288 ------------------------------CSESQFQCASGQCIDGALRCNGDANCQDKS 1317
                                          C   +  C +G CI     C+G  +C+D S
Sbjct: 255  PPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGS 314

Query: 1318 DEKNC--EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEP 1366
            DE +C     C  ++F C NG C  K  +CD + DC D++DE +C PT+ P
Sbjct: 315  DELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC-PTKRP 364


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  102 bits (253), Expect = 4e-21
 Identities = 48/113 (42%), Positives = 63/113 (55%), Gaps = 4/113 (3%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG-QCIDGALRC 1307
            CSP  F C +G+  C+  + RCDG  +C+D SDE NC       ++C S  QC+   + C
Sbjct: 580  CSPSHFKCRSGQ--CVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637

Query: 1308 NGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            +G  +C D  DEKNC   C  D+  CAN  C+ +   CD   DCSD SDE DC
Sbjct: 638  DGFPDCPDYMDEKNCS-FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 49/121 (40%), Positives = 74/121 (61%), Gaps = 9/121 (7%)

Query: 1240 ELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQ 1299
            +L CG       + F C +G   CIP   +C+G+ +C+D SDE +C  CSE+ F C +G+
Sbjct: 266  QLLCGRG-----ENFLCASGI--CIPGKLQCNGYNDCDDWSDEAHCN-CSENLFHCHTGK 317

Query: 1300 CIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD 1359
            C++ +L C+G  +C D SDE+NC+     +  RC +G+CI     CD + DC DKSDE++
Sbjct: 318  CLNYSLVCDGYDDCGDLSDEQNCDCNPTTEH-RCGDGRCIAMEWVCDGDHDCVDKSDEVN 376

Query: 1360 C 1360
            C
Sbjct: 377  C 377



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 50/122 (40%), Positives = 64/122 (52%), Gaps = 7/122 (5%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG 1298
            DE  C     CS   F C TG+  C+  +  CDG+ +C D SDE NC     ++ +C  G
Sbjct: 300  DEAHCN----CSENLFHCHTGK--CLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDG 353

Query: 1299 QCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDEL 1358
            +CI     C+GD +C DKSDE NC          C NGQCI    +CD + DC D SDE 
Sbjct: 354  RCIAMEWVCDGDHDCVDKSDEVNCSCHSQ-GLVECRNGQCIPSTFQCDGDEDCKDGSDEE 412

Query: 1359 DC 1360
            +C
Sbjct: 413  NC 414



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 45/118 (38%), Positives = 61/118 (51%), Gaps = 11/118 (9%)

Query: 1237 LQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA 1296
            L DE +C   PT   +      G+  CI + W CDG  +C D SDE+NC   S+   +C 
Sbjct: 334  LSDEQNCDCNPTTEHR-----CGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECR 388

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL---CLIDQFRCANGQCI---GKHKKCDHN 1348
            +GQCI    +C+GD +C+D SDE+NC V+   C     RC    C+   G    CD N
Sbjct: 389  NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPN 446



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 39/95 (41%), Positives = 50/95 (52%), Gaps = 6/95 (6%)

Query: 1273 FTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFR 1332
            F+  +++  +L C       F CASG CI G L+CNG  +C D SDE +C   C  + F 
Sbjct: 257  FSPQQENGKQLLCG--RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN--CSENLFH 312

Query: 1333 CANGQCIGKHKKCDHNVDCSDKSDE--LDCYPTEE 1365
            C  G+C+     CD   DC D SDE   DC PT E
Sbjct: 313  CHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTE 347



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 4/89 (4%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG 1298
            DE +CG    C  +          C+     CDGF +C D+ DE NC  C + + +CA+ 
Sbjct: 610  DEENCG----CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANH 665

Query: 1299 QCIDGALRCNGDANCQDKSDEKNCEVLCL 1327
             C+   L C+G+A+C D SDE +C  L +
Sbjct: 666  ACVSRDLWCDGEADCSDSSDEWDCVTLSI 694


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  101 bits (252), Expect = 5e-21
 Identities = 53/124 (42%), Positives = 67/124 (54%), Gaps = 5/124 (4%)

Query: 1237 LQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA 1296
            L + LS      C P QFTC TG   CI    RCDG+ +C DHSDELNC   +  QF C 
Sbjct: 441  LAEYLSYDSSDPC-PGQFTCRTGR--CIRKELRCDGWADCTDHSDELNCSCDAGHQFTCK 497

Query: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
            +  C      C+   +C D SDE+ C   C    FRC+NG+C+ K ++C+   DC D SD
Sbjct: 498  NKFCKPLFWVCDSVNDCGDNSDEQGCS--CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSD 555

Query: 1357 ELDC 1360
            E  C
Sbjct: 556  EASC 559



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 53/128 (41%), Positives = 71/128 (55%), Gaps = 13/128 (10%)

Query: 1239 DELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCAS 1297
            DEL+C    +C    QFTC      C P+ W CD   +C D+SDE  C  C    F+C++
Sbjct: 482  DELNC----SCDAGHQFTCKNKF--CKPLFWVCDSVNDCGDNSDEQGCS-CPAQTFRCSN 534

Query: 1298 GQCIDGALRCNGDANCQDKSDEKNCE----VLCLIDQFRCANGQCIGK-HKKCDHNVDCS 1352
            G+C+  + +CNG  +C D SDE +C     V C    +RC NG C+ K + +CD   DCS
Sbjct: 535  GKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCS 594

Query: 1353 DKSDELDC 1360
            D SDE DC
Sbjct: 595  DGSDEKDC 602



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 32/91 (35%), Positives = 50/91 (54%), Gaps = 12/91 (13%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-----VCSESQF 1293
            DE  C    +C  Q F C  G+  C+  + +C+G  +C D SDE +CP      C++  +
Sbjct: 519  DEQGC----SCPAQTFRCSNGK--CLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTY 572

Query: 1294 QCASGQCID-GALRCNGDANCQDKSDEKNCE 1323
            +C +G C+  G   C+G  +C D SDEK+C+
Sbjct: 573  RCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score =  100 bits (250), Expect = 9e-21
 Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 20/200 (10%)

Query: 1200 QEYRQHPCAQDNGGCSHICLVKGDGTTRCS----CPMHLVLLQDELSCGE--------PP 1247
            QE + H C  D G C  +     +G   C     C  H  L  ++  CG+         P
Sbjct: 1356 QEGQWH-CGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAP 1414

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRC 1307
             C   Q TC +G   C+P+A  CD   +C D +DE + P C +    CA G+C+  AL C
Sbjct: 1415 GCGEGQMTCSSGH--CLPLALLCDRQDDCGDGTDEPSYP-CPQGLLACADGRCLPPALLC 1471

Query: 1308 NGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE--LDCYPT 1363
            +G  +C D +DE++C  +V C+  +  C +G C+G  + CD   DC D +DE    C   
Sbjct: 1472 DGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLP 1531

Query: 1364 EEPAPQATNTVGSVIGVIVT 1383
              P P A+   G   G + T
Sbjct: 1532 SLPTPPASTLPGPSPGSLDT 1551



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 67/216 (31%), Positives = 90/216 (41%), Gaps = 28/216 (12%)

Query: 1247 PTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCIDGA 1304
            P C+  +  C      C+P  W CD   +C D SDE  C  P C E Q  C+SG C+  A
Sbjct: 1374 PACAEGEALCQENG-HCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLA 1432

Query: 1305 LRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTE 1364
            L C+   +C D +DE +    C      CA+G+C+     CD + DC D +DE  C    
Sbjct: 1433 LLCDRQDDCGDGTDEPSYP--CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQV 1490

Query: 1365 EPAPQATNTV-GSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPL 1423
               P   + V G+ +G I                LC     DG     D    GP   PL
Sbjct: 1491 TCVPGEVSCVDGTCLGAI---------------QLC-----DGVWDCPDGADEGPGHCPL 1530

Query: 1424 GYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPP 1459
              +P P +   +LPG S G    +S  +   S  PP
Sbjct: 1531 PSLPTPPA--STLPGPSPGSLDTASSPLASASPAPP 1564



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 44/124 (35%), Positives = 53/124 (42%), Gaps = 16/124 (12%)

Query: 1242 SCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCASG-Q 1299
            S    P C P +F C +GE  C P  WRCD   +C D SDE  C   C+     CA G  
Sbjct: 1558 SASPAPPCGPFEFRCGSGE--CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPH 1615

Query: 1300 CIDGALRCNGDANCQDKSDE--KNCEVLCLID----------QFRCANGQCIGKHKKCDH 1347
            C+     C+G   C D SDE    C  L  +           ++ C NG CIG    CD 
Sbjct: 1616 CVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDG 1675

Query: 1348 NVDC 1351
              DC
Sbjct: 1676 QPDC 1679



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 45/156 (28%), Positives = 61/156 (39%), Gaps = 39/156 (25%)

Query: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCPV--------- 1287
            DE SC    TC P + +C  G   C+     CDG  +C D +DE   +CP+         
Sbjct: 1482 DEESCLGQVTCVPGEVSCVDGT--CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPAS 1539

Query: 1288 -------------------------CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
                                     C   +F+C SG+C     RC+ + +C D SDE+ C
Sbjct: 1540 TLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC 1599

Query: 1323 EVLCLIDQFRCANG-QCIGKHKKCDHNVDCSDKSDE 1357
               C      CA G  C+   + CD    C D SDE
Sbjct: 1600 GGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDE 1635



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 33/113 (29%), Positives = 42/113 (37%), Gaps = 38/113 (33%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP------------------- 1286
            P  C P Q  C    + C+  A  CDG  +C D SDE +C                    
Sbjct: 2388 PVQCGPGQTPCEV--LGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTV 2445

Query: 1287 -----------------VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
                             +CS SQ  C SG+C+    RC+   +CQD SDE  C
Sbjct: 2446 PFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 28/108 (25%), Positives = 39/108 (36%), Gaps = 35/108 (32%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC------------------------- 1322
            C   Q  C    C++ A  C+G  +C D SDE++C                         
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450

Query: 1323 ----------EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
                        LC   Q  C +G+C+   ++CD   DC D SDE  C
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 16/40 (40%), Positives = 25/40 (62%)

Query: 1286 PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
            P+C     +CASG+C+     C+G  +C+D SDE+ C +L
Sbjct: 2232 PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLL 2271



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 2/40 (5%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVC 1288
            CSP Q +C +GE  C+    RCD   +C+D SDE  C  C
Sbjct: 2464 CSPSQLSCGSGE--CLSAERRCDLRPDCQDGSDEDGCVDC 2501



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 21/60 (35%), Positives = 27/60 (45%), Gaps = 2/60 (3%)

Query: 1231 PMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSE 1290
            P+ + LL  E      P C      C +GE  C+     CDG  +CED SDE  C +  E
Sbjct: 2216 PLQVELLGCEPGSPPAPLCPGVGLRCASGE--CVLRGGPCDGVLDCEDGSDEEGCVLLPE 2273



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 16/36 (44%), Positives = 21/36 (58%)

Query: 1325 LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            LC     RCA+G+C+ +   CD  +DC D SDE  C
Sbjct: 2233 LCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268


>gi|208973262 low density lipoprotein-related protein 12 isoform b
            precursor [Homo sapiens]
          Length = 840

 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 55/152 (36%), Positives = 75/152 (49%), Gaps = 6/152 (3%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA-SGQCIDGALRC 1307
            C P +  C  G   C     RCDG+  C +  DE NC +C + +F C+ +G C   + RC
Sbjct: 356  CLPWEIPC-GGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 414

Query: 1308 NGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPA 1367
            N   +C + SDEKNC   C    F C N +C+ +   CD   DC D SDE +C P   P 
Sbjct: 415  NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC-PVIVPT 472

Query: 1368 PQATNTV-GSVI-GVIVTIFVSGTVYFICQRM 1397
               T  V GS+I G+++ I +  T      RM
Sbjct: 473  RVITAAVIGSLICGLLLVIALGCTCKLYSLRM 504



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 19/97 (19%)

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------------PVCSESQ 1292
            E P C+  QF C  G+  CIP AW+C+   EC D SDE  C              C+ +Q
Sbjct: 143  EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 200

Query: 1293 FQCASG-----QCIDGALRCNGDANCQDKSDEKNCEV 1324
            FQC S       C+  +L+C+G+ +C D  DE +C+V
Sbjct: 201  FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 237



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 16/91 (17%)

Query: 1286 PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCE-----------VLCLIDQFRCA 1334
            P C+  QF+C +G+CI  A +CN    C D SDE+ C              C  +QF+C 
Sbjct: 145  PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204

Query: 1335 NG-----QCIGKHKKCDHNVDCSDKSDELDC 1360
            +       C+ +  KCD N+DC D  DE+DC
Sbjct: 205  SRFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 4/99 (4%)

Query: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
            RC    H    +DE +C     C  ++F C    + C P + RC+    C + SDE NC 
Sbjct: 375  RCDGYWHCPNGRDETNC---TMCQKEEFPCSRNGV-CYPRSDRCNYQNHCPNGSDEKNCF 430

Query: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
             C    F C + +C+  +  C+   +C D SDE+NC V+
Sbjct: 431  FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 24/55 (43%), Positives = 30/55 (54%), Gaps = 4/55 (7%)

Query: 1316 KSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQA 1370
            KS+E NC      DQFRC NG+CI +  KC++  +C D SDE  C     P   A
Sbjct: 141  KSEEPNCAC----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191


>gi|7305525 low density lipoprotein-related protein 12 isoform a
            precursor [Homo sapiens]
          Length = 859

 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 55/152 (36%), Positives = 75/152 (49%), Gaps = 6/152 (3%)

Query: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA-SGQCIDGALRC 1307
            C P +  C  G   C     RCDG+  C +  DE NC +C + +F C+ +G C   + RC
Sbjct: 375  CLPWEIPC-GGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 433

Query: 1308 NGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPA 1367
            N   +C + SDEKNC   C    F C N +C+ +   CD   DC D SDE +C P   P 
Sbjct: 434  NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC-PVIVPT 491

Query: 1368 PQATNTV-GSVI-GVIVTIFVSGTVYFICQRM 1397
               T  V GS+I G+++ I +  T      RM
Sbjct: 492  RVITAAVIGSLICGLLLVIALGCTCKLYSLRM 523



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 19/97 (19%)

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------------PVCSESQ 1292
            E P C+  QF C  G+  CIP AW+C+   EC D SDE  C              C+ +Q
Sbjct: 162  EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219

Query: 1293 FQCASG-----QCIDGALRCNGDANCQDKSDEKNCEV 1324
            FQC S       C+  +L+C+G+ +C D  DE +C+V
Sbjct: 220  FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 16/91 (17%)

Query: 1286 PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCE-----------VLCLIDQFRCA 1334
            P C+  QF+C +G+CI  A +CN    C D SDE+ C              C  +QF+C 
Sbjct: 164  PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223

Query: 1335 NG-----QCIGKHKKCDHNVDCSDKSDELDC 1360
            +       C+ +  KCD N+DC D  DE+DC
Sbjct: 224  SRFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 4/99 (4%)

Query: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
            RC    H    +DE +C     C  ++F C    + C P + RC+    C + SDE NC 
Sbjct: 394  RCDGYWHCPNGRDETNC---TMCQKEEFPCSRNGV-CYPRSDRCNYQNHCPNGSDEKNCF 449

Query: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
             C    F C + +C+  +  C+   +C D SDE+NC V+
Sbjct: 450  FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 24/55 (43%), Positives = 30/55 (54%), Gaps = 4/55 (7%)

Query: 1316 KSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQA 1370
            KS+E NC      DQFRC NG+CI +  KC++  +C D SDE  C     P   A
Sbjct: 160  KSEEPNCAC----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 210


>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
            sapiens]
          Length = 1542

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 45/128 (35%), Positives = 66/128 (51%), Gaps = 10/128 (7%)

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------PVCSESQFQCASG 1298
            +P  C   QF+C    + C+P++ +CDG  +C D SDE++C      P+CS  +F C++ 
Sbjct: 1334 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1392

Query: 1299 QCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCSD-KS 1355
            +CI   L C+G  +C    DE  C    C      CA +  CI  H++CD   DC D + 
Sbjct: 1393 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452

Query: 1356 DELDCYPT 1363
            DE  C  T
Sbjct: 1453 DESSCSDT 1460



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 22/48 (45%), Positives = 26/48 (54%)

Query: 1310 DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            D + QD S   + E  C   +F CAN  CI K K CD   DC+D SDE
Sbjct: 613  DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)

Query: 1326 CLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C  ++F C ++G CI K +KCD   DC DKSDE  C
Sbjct: 415  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 15/33 (45%), Positives = 19/33 (57%)

Query: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            I  F C + +CI  H  CD+  DCS +SDE  C
Sbjct: 1122 ITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 3/64 (4%)

Query: 1288 CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKK 1344
            C++++F C S G CI+   +C+   +C DKSDE +C  EV     +  C   Q I  H  
Sbjct: 415  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474

Query: 1345 CDHN 1348
             D N
Sbjct: 475  QDSN 478



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC--ANGQCIGKHKKC 1345
            C++ +F CA+  CI     C+   +C D SDE     +C     RC      C  K +K 
Sbjct: 629  CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT--FICRTSSGRCDFEFDLCSWKQEK- 685

Query: 1346 DHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTI 1384
            D + D + K+  +    TE   P A +T+G+  G  + I
Sbjct: 686  DEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFI 721



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 4/52 (7%)

Query: 1312 NCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
            NC      ++CE L   D F C + + CI K + CD   DC D++DE++C P
Sbjct: 178  NCTLPLPAESCEGL---DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP 226



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 26/99 (26%), Positives = 40/99 (40%), Gaps = 15/99 (15%)

Query: 1287 VCSE-SQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKC 1345
            +C E + F C   +CI   L C+   +C  +SDE +C        +    G C  +    
Sbjct: 1118 LCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA------HYTSTTGSCNFETSSG 1171

Query: 1346 DHNVDCS---DKSDELDC-----YPTEEPAPQATNTVGS 1376
            +    CS   D  D+LD       P +   P + +T GS
Sbjct: 1172 NWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS 1210



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCS 1289
            P  C+  +F C   +  CI    +CD   +C D SDE +C   VCS
Sbjct: 412  PHNCTDNEFIC-RSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456


>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
            sapiens]
          Length = 1817

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 45/128 (35%), Positives = 66/128 (51%), Gaps = 10/128 (7%)

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------PVCSESQFQCASG 1298
            +P  C   QF+C    + C+P++ +CDG  +C D SDE++C      P+CS  +F C++ 
Sbjct: 1609 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1667

Query: 1299 QCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCSD-KS 1355
            +CI   L C+G  +C    DE  C    C      CA +  CI  H++CD   DC D + 
Sbjct: 1668 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1727

Query: 1356 DELDCYPT 1363
            DE  C  T
Sbjct: 1728 DESSCSDT 1735



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 19/33 (57%), Positives = 22/33 (66%)

Query: 1325 LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            LC  D+F C +GQCI K   CD   DCSD+SDE
Sbjct: 73   LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 22/48 (45%), Positives = 26/48 (54%)

Query: 1310 DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            D + QD S   + E  C   +F CAN  CI K K CD   DC+D SDE
Sbjct: 888  DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 935



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)

Query: 1326 CLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C  ++F C ++G CI K +KCD   DC DKSDE  C
Sbjct: 690  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 16/33 (48%), Positives = 20/33 (60%)

Query: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            I  F C + +CI  H  CD+  DCSD+SDE  C
Sbjct: 1397 ITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC 1429



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 15/33 (45%), Positives = 20/33 (60%)

Query: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDE 1319
            +CS  +F C SGQCI     C+   +C D+SDE
Sbjct: 73   LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 3/64 (4%)

Query: 1288 CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKK 1344
            C++++F C S G CI+   +C+   +C DKSDE +C  EV     +  C   Q I  H  
Sbjct: 690  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 749

Query: 1345 CDHN 1348
             D N
Sbjct: 750  QDSN 753



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC--ANGQCIGKHKKC 1345
            C++ +F CA+  CI     C+   +C D SDE     +C     RC      C  K +K 
Sbjct: 904  CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT--FICRTSSGRCDFEFDLCSWKQEK- 960

Query: 1346 DHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTI 1384
            D + D + K+  +    TE   P A +T+G+  G  + I
Sbjct: 961  DEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFI 996



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 15/99 (15%)

Query: 1287 VCSE-SQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKC 1345
            +C E + F C   +CI   L C+   +C D+SDE +C        +    G C  +    
Sbjct: 1393 LCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCA------HYTSTTGSCNFETSSG 1446

Query: 1346 DHNVDCS---DKSDELDC-----YPTEEPAPQATNTVGS 1376
            +    CS   D  D+LD       P +   P + +T GS
Sbjct: 1447 NWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS 1485



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 4/52 (7%)

Query: 1312 NCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
            NC      ++CE L   D F C + + CI K + CD   DC D++DE++C P
Sbjct: 453  NCTLPLPAESCEGL---DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP 501



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCS 1289
            P  C+  +F C   +  CI    +CD   +C D SDE +C   VCS
Sbjct: 687  PHNCTDNEFIC-RSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731



 Score = 32.0 bits (71), Expect = 5.0
 Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 5/44 (11%)

Query: 1242 SCGEPPT---CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
            +CG+  +   CS  +F C +G+  CI     CD   +C D SDE
Sbjct: 64   ACGQTQSRKLCSADEFPCTSGQ--CIAKESVCDSRQDCSDESDE 105


>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
            sapiens]
          Length = 1817

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 45/128 (35%), Positives = 66/128 (51%), Gaps = 10/128 (7%)

Query: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------PVCSESQFQCASG 1298
            +P  C   QF+C    + C+P++ +CDG  +C D SDE++C      P+CS  +F C++ 
Sbjct: 1609 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTD 1667

Query: 1299 QCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCSD-KS 1355
            +CI   L C+G  +C    DE  C    C      CA +  CI  H++CD   DC D + 
Sbjct: 1668 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1727

Query: 1356 DELDCYPT 1363
            DE  C  T
Sbjct: 1728 DESSCSDT 1735



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 19/33 (57%), Positives = 22/33 (66%)

Query: 1325 LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            LC  D+F C +GQCI K   CD   DCSD+SDE
Sbjct: 73   LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 22/48 (45%), Positives = 26/48 (54%)

Query: 1310 DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
            D + QD S   + E  C   +F CAN  CI K K CD   DC+D SDE
Sbjct: 888  DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 935



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)

Query: 1326 CLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            C  ++F C ++G CI K +KCD   DC DKSDE  C
Sbjct: 690  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 16/33 (48%), Positives = 20/33 (60%)

Query: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
            I  F C + +CI  H  CD+  DCSD+SDE  C
Sbjct: 1397 ITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC 1429



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 15/33 (45%), Positives = 20/33 (60%)

Query: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDE 1319
            +CS  +F C SGQCI     C+   +C D+SDE
Sbjct: 73   LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 3/64 (4%)

Query: 1288 CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKK 1344
            C++++F C S G CI+   +C+   +C DKSDE +C  EV     +  C   Q I  H  
Sbjct: 690  CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 749

Query: 1345 CDHN 1348
             D N
Sbjct: 750  QDSN 753



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC--ANGQCIGKHKKC 1345
            C++ +F CA+  CI     C+   +C D SDE     +C     RC      C  K +K 
Sbjct: 904  CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT--FICRTSSGRCDFEFDLCSWKQEK- 960

Query: 1346 DHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTI 1384
            D + D + K+  +    TE   P A +T+G+  G  + I
Sbjct: 961  DEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFI 996



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 15/99 (15%)

Query: 1287 VCSE-SQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKC 1345
            +C E + F C   +CI   L C+   +C D+SDE +C        +    G C  +    
Sbjct: 1393 LCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCA------HYTSTTGSCNFETSSG 1446

Query: 1346 DHNVDCS---DKSDELDC-----YPTEEPAPQATNTVGS 1376
            +    CS   D  D+LD       P +   P + +T GS
Sbjct: 1447 NWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS 1485



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 4/52 (7%)

Query: 1312 NCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
            NC      ++CE L   D F C + + CI K + CD   DC D++DE++C P
Sbjct: 453  NCTLPLPAESCEGL---DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP 501



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCS 1289
            P  C+  +F C   +  CI    +CD   +C D SDE +C   VCS
Sbjct: 687  PHNCTDNEFIC-RSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 4/57 (7%)

Query: 1281 DELNCPV----CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC 1333
            +EL  P+    C     +C +G+C      CN   NC D +DE  C   C  ++  C
Sbjct: 1112 EELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWC 1168



 Score = 32.0 bits (71), Expect = 5.0
 Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 5/44 (11%)

Query: 1242 SCGEPPT---CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE 1282
            +CG+  +   CS  +F C +G+  CI     CD   +C D SDE
Sbjct: 64   ACGQTQSRKLCSADEFPCTSGQ--CIAKESVCDSRQDCSDESDE 105


>gi|167555125 low density lipoprotein receptor-related protein 3 [Homo
            sapiens]
          Length = 770

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 45/135 (33%), Positives = 59/135 (43%), Gaps = 3/135 (2%)

Query: 1259 GEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQC--ASGQCIDGALRCNGDANCQDK 1316
            G+  C     RCDG+  C    DE  CP C   Q+ C   SG C   A RCN   +C D 
Sbjct: 387  GDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446

Query: 1317 SDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGS 1376
            +DEKNC   C    F C    CI +  +CD   DC D SDE  C             +GS
Sbjct: 447  ADEKNC-FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGS 505

Query: 1377 VIGVIVTIFVSGTVY 1391
            ++  ++ +   G  +
Sbjct: 506  LVCGLLLVIALGCAF 520



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 37/96 (38%), Positives = 44/96 (45%), Gaps = 3/96 (3%)

Query: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
            RC    H    +DE  C   P C P Q+ C  G   C   A RC+    C D +DE NC 
Sbjct: 397  RCDGWWHCASGRDEQGC---PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF 453

Query: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
             C    F C +  CI    RC+G  +CQD SDE  C
Sbjct: 454  SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 11/84 (13%)

Query: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV--------LCLIDQFRCANG--- 1336
            C   +F+C +G+C+ G  +CN    C D SDE NC          LC    F C+     
Sbjct: 166  CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225

Query: 1337 QCIGKHKKCDHNVDCSDKSDELDC 1360
            +C+   ++CD   DC D SDE  C
Sbjct: 226  RCLPVERRCDGLQDCGDGSDEAGC 249



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 14/87 (16%)

Query: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC---------PVCSESQFQCA-- 1296
            +C   +F C  G+  C+P  W+C+   EC D SDE NC          +C    F C+  
Sbjct: 165  SCQADEFRCDNGK--CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222

Query: 1297 -SGQCIDGALRCNGDANCQDKSDEKNC 1322
             S +C+    RC+G  +C D SDE  C
Sbjct: 223  RSTRCLPVERRCDGLQDCGDGSDEAGC 249



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 17/100 (17%)

Query: 1222 GDGTTRCSCPMHLVLLQDELSCGEPP--TCSPQQFTCFTGEID-CIPVAWRCDGFTECED 1278
            GDG+   +C              EPP   C    F C       C+PV  RCDG  +C D
Sbjct: 192  GDGSDEGNC---------SAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242

Query: 1279 HSDELNCP--VCSE---SQFQCASGQCIDGALRCNGDANC 1313
             SDE  CP   C     S +   +   + GA R   D +C
Sbjct: 243  GSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC 282


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,654,960
Number of Sequences: 37866
Number of extensions: 3419091
Number of successful extensions: 15437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 10284
Number of HSP's gapped (non-prelim): 2230
length of query: 1613
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1497
effective length of database: 13,855,062
effective search space: 20741027814
effective search space used: 20741027814
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.