Guide to the Human Genome
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Search of human proteins with 148664190

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148664190 immunoglobulin superfamily, member 4D isoform 1
[Homo sapiens]
         (442 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148664190 immunoglobulin superfamily, member 4D isoform 1 [Ho...   884   0.0  
gi|148664211 immunoglobulin superfamily, member 4D isoform 2 [Ho...   812   0.0  
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]      342   4e-94
gi|21686977 cell adhesion molecule 4 [Homo sapiens]                   290   2e-78
gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens]        277   2e-74
gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens]         271   1e-72
gi|11386199 poliovirus receptor-related 3 [Homo sapiens]              118   1e-26
gi|51593098 class-I MHC-restricted T cell associated molecule [H...    94   2e-19
gi|112789532 poliovirus receptor related 2 isoform delta precurs...    87   4e-17
gi|5360210 poliovirus receptor related 2 isoform alpha precursor...    86   5e-17
gi|42560237 poliovirus receptor-related 1 isoform 1 [Homo sapiens]     84   2e-16
gi|209413732 poliovirus receptor isoform delta [Homo sapiens]          84   2e-16
gi|209413728 poliovirus receptor isoform beta [Homo sapiens]           84   2e-16
gi|209413726 poliovirus receptor isoform alpha [Homo sapiens]          84   2e-16
gi|222136611 poliovirus receptor-related 4 [Homo sapiens]              84   3e-16
gi|209413730 poliovirus receptor isoform gamma [Homo sapiens]          82   7e-16
gi|166295173 kin of IRRE like [Homo sapiens]                           80   5e-15
gi|221316762 neurotrimin isoform 4 [Homo sapiens]                      79   8e-15
gi|221316757 neurotrimin isoform 3 [Homo sapiens]                      79   8e-15
gi|7705413 neurotrimin isoform 1 [Homo sapiens]                        79   8e-15
gi|42560231 poliovirus receptor-related 1 isoform 2 [Homo sapiens]     78   2e-14
gi|42560233 poliovirus receptor-related 1 isoform 3 [Homo sapiens]     77   3e-14
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi...    76   5e-14
gi|110349719 titin isoform N2-A [Homo sapiens]                         75   9e-14
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             75   9e-14
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    75   9e-14
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    75   9e-14
gi|115298665 neurotrimin isoform 2 [Homo sapiens]                      75   9e-14
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    75   1e-13
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...    75   2e-13

>gi|148664190 immunoglobulin superfamily, member 4D isoform 1 [Homo
           sapiens]
          Length = 442

 Score =  884 bits (2283), Expect = 0.0
 Identities = 442/442 (100%), Positives = 442/442 (100%)

Query: 1   MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA 60
           MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA
Sbjct: 1   MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA 60

Query: 61  TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG 120
           TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG
Sbjct: 61  TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG 120

Query: 121 RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180
           RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF
Sbjct: 121 RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180

Query: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240
           KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ
Sbjct: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240

Query: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI 300
           YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI
Sbjct: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI 300

Query: 301 NNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITD 360
           NNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITD
Sbjct: 301 NNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITD 360

Query: 361 SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA 420
           SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA
Sbjct: 361 SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA 420

Query: 421 DTAIINAEGGQNNSEEKKEYFI 442
           DTAIINAEGGQNNSEEKKEYFI
Sbjct: 421 DTAIINAEGGQNNSEEKKEYFI 442


>gi|148664211 immunoglobulin superfamily, member 4D isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  812 bits (2098), Expect = 0.0
 Identities = 414/442 (93%), Positives = 414/442 (93%), Gaps = 28/442 (6%)

Query: 1   MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA 60
           MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA
Sbjct: 1   MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA 60

Query: 61  TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG 120
           TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG
Sbjct: 61  TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG 120

Query: 121 RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180
           RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF
Sbjct: 121 RYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180

Query: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240
           KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ
Sbjct: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240

Query: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI 300
           YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI
Sbjct: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI 300

Query: 301 NNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITD 360
           NNLNKTDNGTYRCEASNIVGKAHSDYMLYVY                            D
Sbjct: 301 NNLNKTDNGTYRCEASNIVGKAHSDYMLYVY----------------------------D 332

Query: 361 SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA 420
           SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA
Sbjct: 333 SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA 392

Query: 421 DTAIINAEGGQNNSEEKKEYFI 442
           DTAIINAEGGQNNSEEKKEYFI
Sbjct: 393 DTAIINAEGGQNNSEEKKEYFI 414


>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
          Length = 437

 Score =  342 bits (877), Expect = 4e-94
 Identities = 189/415 (45%), Positives = 261/415 (62%), Gaps = 19/415 (4%)

Query: 44  GQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFS 103
           GQ   T++VTV+EG  A ++C+V+++D++ +Q  NP +QT+YF D + L+D+R +L+  S
Sbjct: 26  GQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRAS 85

Query: 104 SSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIE 163
             EL +S+++VS+SDEG+Y C L+T P + S   +TVL  P    I       +EG+ ++
Sbjct: 86  WHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQ 145

Query: 164 VNCTAMASKPATTIRWFKGNTELKGKSEVEEWS---DMYTVTSQLMLKVHKEDDGVPVIC 220
           + C    SKPA  IRWFK + E+K    ++E       +TV+S L  +V + DDGV VIC
Sbjct: 146 LTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVIC 205

Query: 221 QVEHPAVTGNLQ-TQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVT 279
           +V+H ++    Q   + LE+ Y P V I    P     +EG  L LTCE+ GKP P  V 
Sbjct: 206 RVDHESLNATPQVAMQVLEIHYTPSVKI---IPSTPFPQEGQPLILTCESKGKPLPEPVL 262

Query: 280 WVRVDDEM--PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
           W +   E+  P   V+SG  L I  LNKTDNGTYRCEA+N +G++ ++Y+L V+D P T+
Sbjct: 263 WTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTL 322

Query: 338 PPPTTTTTTTTTTTTTILTIITD-SRAGEEGSIR---------AVDHAVIGGVVAVVVFA 387
            P T   + TT T TT + I T  + +    SIR           DHA+IGG+VAVVVF 
Sbjct: 323 LPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFV 382

Query: 388 MLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI 442
            LC + +LGRY ARHKGTY T+EAKGA+DA DADTAIINAEG Q N+EEKKEYFI
Sbjct: 383 TLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI 437


>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
          Length = 388

 Score =  290 bits (741), Expect = 2e-78
 Identities = 158/416 (37%), Positives = 242/416 (58%), Gaps = 40/416 (9%)

Query: 29  LLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRD 88
           LLLL++AAA    G GQ + T++VTV EG VA I+C++++ D S++ + NP RQT++F  
Sbjct: 11  LLLLWAAAA--GPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNG 68

Query: 89  FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLM 148
            R LKD RFQL  FS   +++ L++  + DEG YFCQLYT+       T+TVLV P N +
Sbjct: 69  TRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128

Query: 149 IDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLK 208
           +++ ++ AVEG E+E++C    S+PA T+RW++   ELKG S  +E   +++V S +  +
Sbjct: 129 VEV-REQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFR 187

Query: 209 VHKEDDGVPVICQVEHPAVTG--NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELT 266
           V ++DDG  +IC+ ++ A+    + QTQ  L+VQY P   I  +   Q + REGD L LT
Sbjct: 188 VDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS---QAVVREGDTLVLT 244

Query: 267 CEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDY 326
           C   G P+P  + W R ++ +P+ A   G  L +  L   DNGTY CEASN  G A + Y
Sbjct: 245 CAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALY 304

Query: 327 MLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVF 386
           +L VYDP   +   T                             +V +A++GG++A++VF
Sbjct: 305 VLVVYDPGAVVEAQT-----------------------------SVPYAIVGGILALLVF 335

Query: 387 AMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI 442
            ++C+L+ +     R KG+Y THEA G D+  +A  A +N   G +  + K+E+FI
Sbjct: 336 LIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLN---GSDGHKRKEEFFI 388


>gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens]
          Length = 398

 Score =  277 bits (708), Expect = 2e-74
 Identities = 166/430 (38%), Positives = 239/430 (55%), Gaps = 44/430 (10%)

Query: 22  PGLRLRLLLLLFSAAALIPTG-----DGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQL 76
           P   L LLLLLF A    P G     D    +T D TV+ G    + CQV   +DS +Q 
Sbjct: 4   PAASLLLLLLLF-ACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQW 62

Query: 77  LNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT 136
            NP +QT+YF + R L+D+R QL+  +  EL +S++NV+++DEG Y C ++T P + + +
Sbjct: 63  SNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKS 122

Query: 137 TITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGK-SEVEEW 195
            +TVL  P+  +I   K +  E +   +NC +  SKPA  + W KG+ EL G+ + ++E 
Sbjct: 123 LVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQED 182

Query: 196 SD--MYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG-NLQTQRYLEVQYKPQVHIQMTYP 252
            +   +TV+S +  +V +EDDG  ++C V H ++ G +  T + +EV Y P   I+   P
Sbjct: 183 PNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPP 242

Query: 253 LQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYR 312
                REG  L L CE  G P P    W + +  +P   +     L    LNK+D+GTY 
Sbjct: 243 ---HPREGQKLLLHCEGRGNPVPQQYLWEK-EGSVPPLKMTQESALIFPFLNKSDSGTYG 298

Query: 313 CEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAV 372
           C A++ +G   + Y L V DP    P P++++T                           
Sbjct: 299 CTATSNMGSYKAYYTLNVNDPS---PVPSSSSTY-------------------------- 329

Query: 373 DHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQN 432
            HA+IGG+VA +VF +L +LI LG Y  RHKGTY THEAKG+DDA DADTAIINAEGGQ+
Sbjct: 330 -HAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQS 388

Query: 433 NSEEKKEYFI 442
             ++KKEYFI
Sbjct: 389 GGDDKKEYFI 398


>gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens]
          Length = 432

 Score =  271 bits (692), Expect = 1e-72
 Identities = 157/415 (37%), Positives = 236/415 (56%), Gaps = 39/415 (9%)

Query: 32  LFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRP 91
           ++S+  ++ + D Q  +T D TV+ G    + CQV   +DS +Q  NP +QT+YF + R 
Sbjct: 53  VWSSPDMLASQDSQP-WTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRA 111

Query: 92  LKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDI 151
           L+D+R QL+  +  EL +S++NV+++DEG Y C ++T P + + + +TVL  P+  +I  
Sbjct: 112 LRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITG 171

Query: 152 QKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGK-SEVEEWSD--MYTVTSQLMLK 208
            K +  E +   +NC +  SKPA  + W KG+ EL G+ + ++E  +   +TV+S +  +
Sbjct: 172 YKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQ 231

Query: 209 VHKEDDGVPVICQVEHPAVTG-NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTC 267
           V +EDDG  ++C V H ++ G +  T + +EV Y P   I+   P     REG  L L C
Sbjct: 232 VTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPP---HPREGQKLLLHC 288

Query: 268 EAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYM 327
           E  G P P    W + +  +P   +     L    LNK+D+GTY C A++ +G   + Y 
Sbjct: 289 EGRGNPVPQQYLWEK-EGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYT 347

Query: 328 LYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFA 387
           L V DP    P P++++T                            HA+IGG+VA +VF 
Sbjct: 348 LNVNDPS---PVPSSSSTY---------------------------HAIIGGIVAFIVFL 377

Query: 388 MLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI 442
           +L +LI LG Y  RHKGTY THEAKG+DDA DADTAIINAEGGQ+  ++KKEYFI
Sbjct: 378 LLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI 432


>gi|11386199 poliovirus receptor-related 3 [Homo sapiens]
          Length = 549

 Score =  118 bits (295), Expect = 1e-26
 Identities = 109/439 (24%), Positives = 195/439 (44%), Gaps = 43/439 (9%)

Query: 3   SVVLPSGSQCAAAAAAAAPPGLRLR------LLLLLFSA---AALIPTGDGQNLFTKDVT 53
           S + P G +   ++A+    GL L+      LLLLLF     + L     G  +    VT
Sbjct: 8   SPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVT 67

Query: 54  VIEGEVATISC--QVNKSDDSVI--QLLNPNRQTI------YFRDFRPLKDSRFQLLNFS 103
            + G+  ++ C  +VN++   +   ++   + QT+      Y    +     R    N+S
Sbjct: 68  AVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYS 127

Query: 104 SSELKVSLTNVSISDEGRYFCQLYTDP--PQESYTTITVLVPPRNLMIDIQKDTAVEG-- 159
            ++  ++L N+  SD G+Y C+  T P    +S TT+TVLV P   +I    D+ ++G  
Sbjct: 128 LNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIK-GPDSLIDGGN 186

Query: 160 EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
           E +   C A   KP   I W +G+      +     ++  T+ SQ  L   +   G  + 
Sbjct: 187 ETVAAICIAATGKPVAHIDW-EGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRIT 245

Query: 220 CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVT 279
           C V+HPA+  +++    L++QY P+V +        + R+G  + L C A   P P    
Sbjct: 246 CVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKG--VNLKCNADANPPPFKSV 303

Query: 280 WVRVDDEMPQHAVLSGPNL-FINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
           W R+D + P   + S   L F++ L    +G Y C+ +N +G+     ++Y+ DPPTT  
Sbjct: 304 WSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTT 363

Query: 339 --------PPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLC 390
                   P T       T    +   ++     ++ +I  +  +V+GG + +V+ ++L 
Sbjct: 364 LQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLA 423

Query: 391 LLI-------ILGRYFARH 402
            +          G YFA++
Sbjct: 424 GIFCYRRRRTFRGDYFAKN 442


>gi|51593098 class-I MHC-restricted T cell associated molecule [Homo
           sapiens]
          Length = 393

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 55/183 (30%), Positives = 94/183 (51%), Gaps = 2/183 (1%)

Query: 49  TKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELK 108
           T+ +TV EG+  T+ C  +   +S +Q L P+  TI+  ++  LK+S++QLL+ S+++L 
Sbjct: 23  TETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLS 82

Query: 109 VSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEE-IEVNCT 167
           +++ NV++ DEG Y C  Y+D        + VL  P   +++        GEE + + C+
Sbjct: 83  ITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCS 142

Query: 168 AMASKPATTIRWFKGNT-ELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA 226
            M SKP   I W  GN+ E+ G +  E  +D     +   L +H       V C + H  
Sbjct: 143 TMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRG 202

Query: 227 VTG 229
           + G
Sbjct: 203 LQG 205


>gi|112789532 poliovirus receptor related 2 isoform delta precursor
           [Homo sapiens]
          Length = 538

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 67/251 (26%), Positives = 102/251 (40%), Gaps = 6/251 (2%)

Query: 89  FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQE--SYTTITVLVPPRN 146
           F   K S  Q       +  ++L  +++ DEG Y C+  T P       T + V+  P+N
Sbjct: 105 FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKN 164

Query: 147 LMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKG-NTELKGKSEVEEWSDMYTVTSQL 205
              + QK T  +       C +   +P   I W    + E K        +   TVTS+ 
Sbjct: 165 -QAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRF 223

Query: 206 MLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALEL 265
            L      DGV V C+VEH +          L V+Y P+V I   Y         DA  L
Sbjct: 224 TLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSIS-GYDDNWYLGRTDAT-L 281

Query: 266 TCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSD 325
           +C+    P+P    W       P  AV  G  L I+ ++   N T+ C  +N VG   ++
Sbjct: 282 SCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAE 341

Query: 326 YMLYVYDPPTT 336
            +++V + P T
Sbjct: 342 QVIFVRETPNT 352


>gi|5360210 poliovirus receptor related 2 isoform alpha precursor
           [Homo sapiens]
          Length = 479

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 67/253 (26%), Positives = 102/253 (40%), Gaps = 6/253 (2%)

Query: 89  FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQE--SYTTITVLVPPRN 146
           F   K S  Q       +  ++L  +++ DEG Y C+  T P       T + V+  P+N
Sbjct: 105 FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKN 164

Query: 147 LMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKG-NTELKGKSEVEEWSDMYTVTSQL 205
              + QK T  +       C +   +P   I W    + E K        +   TVTS+ 
Sbjct: 165 -QAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRF 223

Query: 206 MLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALEL 265
            L      DGV V C+VEH +          L V+Y P+V I   Y         DA  L
Sbjct: 224 TLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSIS-GYDDNWYLGRTDAT-L 281

Query: 266 TCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSD 325
           +C+    P+P    W       P  AV  G  L I+ ++   N T+ C  +N VG   ++
Sbjct: 282 SCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAE 341

Query: 326 YMLYVYDPPTTIP 338
            +++V + P   P
Sbjct: 342 QVIFVRETPRASP 354


>gi|42560237 poliovirus receptor-related 1 isoform 1 [Homo sapiens]
          Length = 517

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 84/321 (26%), Positives = 136/321 (42%), Gaps = 30/321 (9%)

Query: 74  IQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPP-- 131
           + + NP+        +R     R + L  S ++  + L+ + + DEG Y C+  T P   
Sbjct: 78  VAIYNPSMGVSVLAPYR----ERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN 133

Query: 132 QESYTTITVLVPPRNLMIDIQKDT-AVEGEEIEV---NCTAMASKPATTIRWFKGNTELK 187
           +ES   +TV+  P N +   Q    A +G++ +V    CT+   KP + + W    T LK
Sbjct: 134 RESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSW---ETRLK 190

Query: 188 GKSEVEEWSD---MYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
           G++E +E  +     TV S+  L   +E     + C V +       +    L VQY+P+
Sbjct: 191 GEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHM--DRFKESLTLNVQYEPE 248

Query: 245 VHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINN-L 303
           V I+       L R    ++LTC+A   P      W  ++  +P+        LF    +
Sbjct: 249 VTIEGFDGNWYLQRMD--VKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPI 306

Query: 304 NKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRA 363
           N +  GTY CEA+N +G       + + + P T  PP          T  I         
Sbjct: 307 NYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAII--------G 358

Query: 364 GEEGSIRAVDHAVIGGVVAVV 384
           G  GSI  V   V+GG+V  +
Sbjct: 359 GVAGSILLV-LIVVGGIVVAL 378


>gi|209413732 poliovirus receptor isoform delta [Homo sapiens]
          Length = 392

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 94/340 (27%), Positives = 138/340 (40%), Gaps = 27/340 (7%)

Query: 14  AAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQV---NKSD 70
           A A AAA P L + LL+L +       TGD        V    G+  T+ C +   N   
Sbjct: 2   ARAMAAAWPLLLVALLVLSWPPPG---TGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEV 58

Query: 71  DSVIQLL----NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVS-------ISDE 119
             V QL       +     F   +    S  + L F ++ L   L N S       + DE
Sbjct: 59  THVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDE 118

Query: 120 GRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEV-NCTAMASKPAT 175
           G Y C L+   PQ S +    + VL  P+N   ++QK   + GE + +  C +   +P  
Sbjct: 119 GNYTC-LFVTFPQGSRSVDIWLRVLAKPQNTA-EVQK-VQLTGEPVPMARCVSTGGRPPA 175

Query: 176 TIRWFKGNTELKGKSEVEEW-SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ 234
            I W      +   S+V  + S   TVTS  +L    + DG  V C+VEH +        
Sbjct: 176 QITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLT 235

Query: 235 RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS 294
             L V Y P+V I   Y       + +A  LTC+A   P+P    W      +P  AV  
Sbjct: 236 VNLTVYYPPEVSIS-GYDNNWYLGQNEAT-LTCDARSNPEPTGYNWSTTMGPLPPFAVAQ 293

Query: 295 GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
           G  L I  ++K  N T  C  +N +G   ++  + V + P
Sbjct: 294 GAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGP 333


>gi|209413728 poliovirus receptor isoform beta [Homo sapiens]
          Length = 372

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 94/340 (27%), Positives = 138/340 (40%), Gaps = 27/340 (7%)

Query: 14  AAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQV---NKSD 70
           A A AAA P L + LL+L +       TGD        V    G+  T+ C +   N   
Sbjct: 2   ARAMAAAWPLLLVALLVLSWPPPG---TGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEV 58

Query: 71  DSVIQLL----NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVS-------ISDE 119
             V QL       +     F   +    S  + L F ++ L   L N S       + DE
Sbjct: 59  THVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDE 118

Query: 120 GRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEV-NCTAMASKPAT 175
           G Y C L+   PQ S +    + VL  P+N   ++QK   + GE + +  C +   +P  
Sbjct: 119 GNYTC-LFVTFPQGSRSVDIWLRVLAKPQNTA-EVQK-VQLTGEPVPMARCVSTGGRPPA 175

Query: 176 TIRWFKGNTELKGKSEVEEW-SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ 234
            I W      +   S+V  + S   TVTS  +L    + DG  V C+VEH +        
Sbjct: 176 QITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLT 235

Query: 235 RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS 294
             L V Y P+V I   Y       + +A  LTC+A   P+P    W      +P  AV  
Sbjct: 236 VNLTVYYPPEVSIS-GYDNNWYLGQNEAT-LTCDARSNPEPTGYNWSTTMGPLPPFAVAQ 293

Query: 295 GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
           G  L I  ++K  N T  C  +N +G   ++  + V + P
Sbjct: 294 GAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGP 333


>gi|209413726 poliovirus receptor isoform alpha [Homo sapiens]
          Length = 417

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 94/340 (27%), Positives = 138/340 (40%), Gaps = 27/340 (7%)

Query: 14  AAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQV---NKSD 70
           A A AAA P L + LL+L +       TGD        V    G+  T+ C +   N   
Sbjct: 2   ARAMAAAWPLLLVALLVLSWPPPG---TGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEV 58

Query: 71  DSVIQLL----NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVS-------ISDE 119
             V QL       +     F   +    S  + L F ++ L   L N S       + DE
Sbjct: 59  THVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDE 118

Query: 120 GRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEV-NCTAMASKPAT 175
           G Y C L+   PQ S +    + VL  P+N   ++QK   + GE + +  C +   +P  
Sbjct: 119 GNYTC-LFVTFPQGSRSVDIWLRVLAKPQNTA-EVQK-VQLTGEPVPMARCVSTGGRPPA 175

Query: 176 TIRWFKGNTELKGKSEVEEW-SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ 234
            I W      +   S+V  + S   TVTS  +L    + DG  V C+VEH +        
Sbjct: 176 QITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLT 235

Query: 235 RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS 294
             L V Y P+V I   Y       + +A  LTC+A   P+P    W      +P  AV  
Sbjct: 236 VNLTVYYPPEVSIS-GYDNNWYLGQNEAT-LTCDARSNPEPTGYNWSTTMGPLPPFAVAQ 293

Query: 295 GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
           G  L I  ++K  N T  C  +N +G   ++  + V + P
Sbjct: 294 GAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGP 333


>gi|222136611 poliovirus receptor-related 4 [Homo sapiens]
          Length = 510

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 108/418 (25%), Positives = 168/418 (40%), Gaps = 73/418 (17%)

Query: 22  PGLRLRLLLLLFSAAALIPTGDGQNLFTKDV-TVIEGEVATISCQVN-KSDDSVIQLL-- 77
           P   L LLLLL S     P G+   L T DV TV+ G+ A + C     S + V Q+   
Sbjct: 12  PEAWLLLLLLLASFTGRCPAGE---LETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWA 68

Query: 78  ----NPNRQTI------YFRDFRPLKDSRFQLLNFSSSEL--KVSLTNVSISDEGRYFCQ 125
                   Q +      Y     P  + R +      + L   V L N   +DEG Y C+
Sbjct: 69  RVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECR 128

Query: 126 LYTDPPQ--ESYTTITVLVPPRNLMIDIQKDTAVE---GEEIEVNCTAMASKPATTIRWF 180
           + T P    ++   + VLVPP   +  +    A+E   G  +  +CTA  S PA ++ W 
Sbjct: 129 VSTFPAGSFQARLRLRVLVPP---LPSLNPGPALEEGQGLTLAASCTAEGS-PAPSVTW- 183

Query: 181 KGNTELKGKSEVEEW--SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLE 238
             +TE+KG +    +  S    VTS+  L   +  +G P+ C V HP +  + +    L 
Sbjct: 184 --DTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILH 241

Query: 239 VQYKPQVHIQ--MTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGP 296
           V +  +  ++      L  + REG  L+  C + G+P P    W R+D  +P    + G 
Sbjct: 242 VSFLAEASVRGLEDQNLWHIGREGAMLK--CLSEGQPPP-SYNWTRLDGPLPSGVRVDGD 298

Query: 297 NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
            L    L    +G Y C  SN      S   + V DP                       
Sbjct: 299 TLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDP----------------------- 335

Query: 357 IITDSRAGEEGSIRAVD----HAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHE 410
                   +E S + VD      V+ GV+A ++F +L ++++L   + R K    T +
Sbjct: 336 --------QEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQK 385


>gi|209413730 poliovirus receptor isoform gamma [Homo sapiens]
          Length = 364

 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 93/336 (27%), Positives = 136/336 (40%), Gaps = 27/336 (8%)

Query: 14  AAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQV---NKSD 70
           A A AAA P L + LL+L +       TGD        V    G+  T+ C +   N   
Sbjct: 2   ARAMAAAWPLLLVALLVLSWPPPG---TGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEV 58

Query: 71  DSVIQLL----NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVS-------ISDE 119
             V QL       +     F   +    S  + L F ++ L   L N S       + DE
Sbjct: 59  THVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDE 118

Query: 120 GRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEV-NCTAMASKPAT 175
           G Y C L+   PQ S +    + VL  P+N   ++QK   + GE + +  C +   +P  
Sbjct: 119 GNYTC-LFVTFPQGSRSVDIWLRVLAKPQNTA-EVQK-VQLTGEPVPMARCVSTGGRPPA 175

Query: 176 TIRWFKGNTELKGKSEVEEW-SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ 234
            I W      +   S+V  + S   TVTS  +L    + DG  V C+VEH +        
Sbjct: 176 QITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLT 235

Query: 235 RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS 294
             L V Y P+V I   Y       + +A  LTC+A   P+P    W      +P  AV  
Sbjct: 236 VNLTVYYPPEVSIS-GYDNNWYLGQNEAT-LTCDARSNPEPTGYNWSTTMGPLPPFAVAQ 293

Query: 295 GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
           G  L I  ++K  N T  C  +N +G   ++  + V
Sbjct: 294 GAQLLIRPVDKPINTTLICNVTNALGARQAELTVQV 329


>gi|166295173 kin of IRRE like [Homo sapiens]
          Length = 757

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 20/261 (7%)

Query: 104 SSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVE-GEEI 162
           + +  + +T+  +SD+  Y CQ      +     +TVL+PP +  ID      ++ G   
Sbjct: 80  AGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPH 139

Query: 163 EVNCTAMASKPATTIRWFKGNTELKG---KSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
            + C A  +KPA TI WF+  T+ +G    +E+ +     T  SQL++     D G    
Sbjct: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199

Query: 220 CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVT 279
           C+  + A+    +T   L+V + P V + +        +EG+ +  TC+A   P+ +   
Sbjct: 200 CRSMNEAIPSGKETSIELDVHHPPTVTLSIE---PQTVQEGERVVFTCQATANPEILGYR 256

Query: 280 WVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
           W +    ++D        +    F             CE  N VG  +   ++ V+  P 
Sbjct: 257 WAKGGFLIEDAHESRYETNVDYSFFTE-------PVSCEVHNKVGSTNVSTLVNVHFAPR 309

Query: 336 TI--PPPTTTTTTTTTTTTTI 354
            +  P PTTT   +  T T +
Sbjct: 310 IVVDPKPTTTDIGSDVTLTCV 330



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 76/265 (28%), Positives = 113/265 (42%), Gaps = 30/265 (11%)

Query: 79  PNRQTIYFRDFRPLKDS--RFQLLNFSSSELKVS--LTNVSISDEGRYF-CQLYTDP-PQ 132
           P    I+FRD    + +    +LL     E  VS  L N +  D GR F C+   +  P 
Sbjct: 150 PAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPS 209

Query: 133 ESYTTITVLVP-PRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSE 191
              T+I + V  P  + + I+  T  EGE +   C A A+      RW KG   ++   E
Sbjct: 210 GKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHE 269

Query: 192 VEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTY 251
                      S+    V       PV C+V +   + N+ T   + V + P++ +    
Sbjct: 270 -----------SRYETNVDYSFFTEPVSCEVHNKVGSTNVST--LVNVHFAPRIVVD--- 313

Query: 252 PLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN-LFINNLNKTDNGT 310
           P    T  G  + LTC  +G P P+ +TW + D  M    VLS  N L + ++ + D GT
Sbjct: 314 PKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSNM----VLSNSNQLLLKSVTQADAGT 368

Query: 311 YRCEA-SNIVGKAHSDYMLYVYDPP 334
           Y C A    +G A  +  LYV  PP
Sbjct: 369 YTCRAIVPRIGVAEREVPLYVNGPP 393


>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
          Length = 316

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 84/318 (26%), Positives = 138/318 (43%), Gaps = 42/318 (13%)

Query: 29  LLLLFSAAALIPTGDGQNLFTK---DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTI- 84
           L LLF     +P   G   F K   +VTV +GE AT+ C +   D+ V ++   NR TI 
Sbjct: 19  LRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTI---DNRVTRVAWLNRSTIL 75

Query: 85  YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTD-PPQESYTTITVLVP 143
           Y  + +   D R  LL+ + ++  + + NV + DEG Y C + TD  P+ S   + V V 
Sbjct: 76  YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135

Query: 144 PRNLMIDIQKDTAV-EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
           P+  +++I  D ++ EG  I + C A   +P  T+ W   + +  G    +E+ ++  +T
Sbjct: 136 PK--IVEISSDISINEGNNISLTCIA-TGRPEPTVTWRHISPKAVGFVSEDEYLEIQGIT 192

Query: 203 SQLMLKVH---KEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL-TR 258
            +           D   PV+ +V+             + V Y P +        +G    
Sbjct: 193 REQSGDYECSASNDVAAPVVRRVK-------------VTVNYPPYIS-----EAKGTGVP 234

Query: 259 EGDALELTCEAIGKPQPVMVTWVRVDDEMPQH----AVLSGP---NLFINNLNKTDNGTY 311
            G    L CEA   P      W + D  + +      V + P    L   N+++ D G Y
Sbjct: 235 VGQKGTLQCEASAVPS-AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNY 293

Query: 312 RCEASNIVGKAHSDYMLY 329
            C ASN +G  ++  ML+
Sbjct: 294 TCVASNKLGHTNASIMLF 311


>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
          Length = 355

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 84/318 (26%), Positives = 138/318 (43%), Gaps = 42/318 (13%)

Query: 29  LLLLFSAAALIPTGDGQNLFTK---DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTI- 84
           L LLF     +P   G   F K   +VTV +GE AT+ C +   D+ V ++   NR TI 
Sbjct: 19  LRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTI---DNRVTRVAWLNRSTIL 75

Query: 85  YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTD-PPQESYTTITVLVP 143
           Y  + +   D R  LL+ + ++  + + NV + DEG Y C + TD  P+ S   + V V 
Sbjct: 76  YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135

Query: 144 PRNLMIDIQKDTAV-EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
           P+  +++I  D ++ EG  I + C A   +P  T+ W   + +  G    +E+ ++  +T
Sbjct: 136 PK--IVEISSDISINEGNNISLTCIA-TGRPEPTVTWRHISPKAVGFVSEDEYLEIQGIT 192

Query: 203 SQLMLKVH---KEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL-TR 258
            +           D   PV+ +V+             + V Y P +        +G    
Sbjct: 193 REQSGDYECSASNDVAAPVVRRVK-------------VTVNYPPYIS-----EAKGTGVP 234

Query: 259 EGDALELTCEAIGKPQPVMVTWVRVDDEMPQH----AVLSGP---NLFINNLNKTDNGTY 311
            G    L CEA   P      W + D  + +      V + P    L   N+++ D G Y
Sbjct: 235 VGQKGTLQCEASAVPS-AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNY 293

Query: 312 RCEASNIVGKAHSDYMLY 329
            C ASN +G  ++  ML+
Sbjct: 294 TCVASNKLGHTNASIMLF 311


>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
          Length = 344

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 84/318 (26%), Positives = 138/318 (43%), Gaps = 42/318 (13%)

Query: 29  LLLLFSAAALIPTGDGQNLFTK---DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTI- 84
           L LLF     +P   G   F K   +VTV +GE AT+ C +   D+ V ++   NR TI 
Sbjct: 19  LRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTI---DNRVTRVAWLNRSTIL 75

Query: 85  YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTD-PPQESYTTITVLVP 143
           Y  + +   D R  LL+ + ++  + + NV + DEG Y C + TD  P+ S   + V V 
Sbjct: 76  YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135

Query: 144 PRNLMIDIQKDTAV-EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
           P+  +++I  D ++ EG  I + C A   +P  T+ W   + +  G    +E+ ++  +T
Sbjct: 136 PK--IVEISSDISINEGNNISLTCIA-TGRPEPTVTWRHISPKAVGFVSEDEYLEIQGIT 192

Query: 203 SQLMLKVH---KEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL-TR 258
            +           D   PV+ +V+             + V Y P +        +G    
Sbjct: 193 REQSGDYECSASNDVAAPVVRRVK-------------VTVNYPPYIS-----EAKGTGVP 234

Query: 259 EGDALELTCEAIGKPQPVMVTWVRVDDEMPQH----AVLSGP---NLFINNLNKTDNGTY 311
            G    L CEA   P      W + D  + +      V + P    L   N+++ D G Y
Sbjct: 235 VGQKGTLQCEASAVPS-AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNY 293

Query: 312 RCEASNIVGKAHSDYMLY 329
            C ASN +G  ++  ML+
Sbjct: 294 TCVASNKLGHTNASIMLF 311


>gi|42560231 poliovirus receptor-related 1 isoform 2 [Homo sapiens]
          Length = 458

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 70/274 (25%), Positives = 121/274 (44%), Gaps = 27/274 (9%)

Query: 74  IQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPP-- 131
           + + NP+        +R     R + L  S ++  + L+ + + DEG Y C+  T P   
Sbjct: 78  VAIYNPSMGVSVLAPYR----ERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN 133

Query: 132 QESYTTITVLVPPRNLMIDIQKD-TAVEGEEIEV---NCTAMASKPATTIRWFKGNTELK 187
           +ES   +TV+  P N +   Q    A +G++ +V    CT+   KP + + W    T LK
Sbjct: 134 RESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSW---ETRLK 190

Query: 188 GKSEVEEW---SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
           G++E +E    +   TV S+  L   +E     + C V +       +    L VQY+P+
Sbjct: 191 GEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH--MDRFKESLTLNVQYEPE 248

Query: 245 VHIQ---MTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFIN 301
           V I+     + LQ +      ++LTC+A   P      W  ++  +P+        LF  
Sbjct: 249 VTIEGFDGNWYLQRMD-----VKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFK 303

Query: 302 N-LNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             +N +  GTY CEA+N +G       + + + P
Sbjct: 304 GPINYSLAGTYICEATNPIGTRSGQVEVNITEKP 337


>gi|42560233 poliovirus receptor-related 1 isoform 3 [Homo sapiens]
          Length = 352

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 69/260 (26%), Positives = 117/260 (45%), Gaps = 27/260 (10%)

Query: 74  IQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPP-- 131
           + + NP+        +R     R + L  S ++  + L+ + + DEG Y C+  T P   
Sbjct: 78  VAIYNPSMGVSVLAPYR----ERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN 133

Query: 132 QESYTTITVLVPPRNLMIDIQKD-TAVEGEEIEV---NCTAMASKPATTIRWFKGNTELK 187
           +ES   +TV+  P N +   Q    A +G++ +V    CT+   KP + + W    T LK
Sbjct: 134 RESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSW---ETRLK 190

Query: 188 GKSEVEEW---SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
           G++E +E    +   TV S+  L   +E     + C V +       +    L VQY+P+
Sbjct: 191 GEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH--MDRFKESLTLNVQYEPE 248

Query: 245 VHIQ---MTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFIN 301
           V I+     + LQ +      ++LTC+A   P      W  ++  +P+        LF  
Sbjct: 249 VTIEGFDGNWYLQRMD-----VKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFK 303

Query: 302 N-LNKTDNGTYRCEASNIVG 320
             +N +  GTY CEA+N +G
Sbjct: 304 GPINYSLAGTYICEATNPIG 323


>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
          Length = 1331

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 38/70 (54%), Positives = 49/70 (70%), Gaps = 2/70 (2%)

Query: 375  AVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGG--QN 432
            A+IGGV+AVV+F +LC L+ L RY  RHKGTY T+EAKGA+ A  AD AI+N +    + 
Sbjct: 1262 AIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTET 1321

Query: 433  NSEEKKEYFI 442
              E KKE+ I
Sbjct: 1322 IDESKKEWLI 1331


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 67/282 (23%), Positives = 128/282 (45%), Gaps = 17/282 (6%)

Query: 84   IYFRDFRPL-KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPP-QESYTTITVL 141
            ++F+D   + ++S    +++S +   +  + V  ++ G+Y CQ+  D   QE + T++VL
Sbjct: 7524 VWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVL 7583

Query: 142  VPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTV 201
              P  ++   +      G+   + CT +A  P  + +WFK   EL   ++ +  S    V
Sbjct: 7584 -EPATIVEKPESIKVTTGDTCTLECT-VAGTPELSTKWFKDGKELTSDNKYKI-SFFNKV 7640

Query: 202  TSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGD 261
            +   ++ V   D GV    +V++P    +      +  +  P    +      GL+  G 
Sbjct: 7641 SGLKIINVAPSDSGVYSF-EVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS--GS 7697

Query: 262  ALELTCEAIGKPQPVMVTWVRVDDEMPQ----HAVLSGPN--LFINNLNKTDNGTYRCEA 315
            ++ + C+  G P P+ V+W    +E+         L+     L +N L ++D+G Y C A
Sbjct: 7698 SVVMECKVYGSP-PISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIA 7756

Query: 316  SNIVGKAHSDYMLYVYDPPTTI--PPPTTTTTTTTTTTTTIL 355
            +N+ G       L V +PP+ +  P P    T T  T T+I+
Sbjct: 7757 TNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIV 7798



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 76/308 (24%), Positives = 127/308 (41%), Gaps = 40/308 (12%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            KD+    G   T++C++N S            Q  ++RD   L+D      +F  +   +
Sbjct: 6182 KDIEQTVGLPVTLTCRLNGSAPI---------QVCWYRDGVLLRDDENLQTSFVDNVATL 6232

Query: 110  SLTNVSISDEGRYFCQLYTDP--PQESYTTITVLVPPRNLMIDIQKDT--AVEGEEIEVN 165
             +    +S  G+Y C   ++P     S   +T   P ++   DI+  +   + GE  +  
Sbjct: 6233 KILQTDLSHSGQYSCSA-SNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFE 6291

Query: 166  CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ------LMLKVHKEDDGVPVI 219
            C    ++P   I W K N E++           YT+T         +LKV K D G    
Sbjct: 6292 CHVTGAQPMR-ITWSKDNKEIRPGGN-------YTITCVGNTPHLRILKVGKGDSG-QYT 6342

Query: 220  CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVT 279
            CQ  +    G       L V+  P+   ++      + ++G++++L C+  G P+ + V+
Sbjct: 6343 CQATNDV--GKDMCSAQLSVKEPPKFVKKLE--ASKVAKQGESIQLECKISGSPE-IKVS 6397

Query: 280  WVRVDDEMPQH------AVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDP 333
            W R D E+ +        + S   L IN  +  D+G Y CEA N VG A     L V  P
Sbjct: 6398 WFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAP 6457

Query: 334  PTTIPPPT 341
            P     P+
Sbjct: 6458 PVFTQKPS 6465



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 72/304 (23%), Positives = 125/304 (41%), Gaps = 31/304 (10%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            + VI GE A   C V  +         P R T + +D + ++      +    +   + +
Sbjct: 6280 IDVIAGESADFECHVTGAQ--------PMRIT-WSKDNKEIRPGGNYTITCVGNTPHLRI 6330

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTT-ITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMA 170
              V   D G+Y CQ   D  ++  +  ++V  PP+ +        A +GE I++ C    
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISG 6390

Query: 171  SKPATTIRWFKGNTELKGKSEVEEWS-DMYTVTSQLMLKVHKE--DDGVPVICQVEHPAV 227
            S P   + WF+ ++EL      E W  +M  + S  +L +++   +D    IC+  +   
Sbjct: 6391 S-PEIKVSWFRNDSELH-----ESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVG 6444

Query: 228  TGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEM 287
              +  T   ++    P V  Q   P+  L  +G  + L CE  G P P  V WV+   ++
Sbjct: 6445 DASCSTALTVKA---PPVFTQKPSPVGAL--KGSDVILQCEISGTP-PFEVVWVKDRKQV 6498

Query: 288  PQHAVLS------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPT 341
                           +L I NL  +D G Y C+A+N VG       +   +PP  +   +
Sbjct: 6499 RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLS 6558

Query: 342  TTTT 345
             T+T
Sbjct: 6559 DTST 6562



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 71/320 (22%), Positives = 135/320 (42%), Gaps = 31/320 (9%)

Query: 34   SAAALIPTGDGQN-----LFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRD 88
            S+A LI T +G+N     +    V  + GE A   C V  +    +          + +D
Sbjct: 8140 SSARLILT-EGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS---------WAKD 8189

Query: 89   FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT-ITV---LVPP 144
             R ++      +++  +   +++  V   D G+Y C    +  ++S T  + +   L+PP
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPP 8249

Query: 145  RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ 204
                   +     EG   ++      S+P T + W+K N E++  S  E      T+  Q
Sbjct: 8250 SFTKRLSETVEETEGNSFKLEGRVAGSQPIT-VAWYKNNIEIQPTSNCEITFKNNTLVLQ 8308

Query: 205  LMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALE 264
            +  K    D G+   C+V + A +    +   ++   KP V  Q   P+     EG+ ++
Sbjct: 8309 VR-KAGMNDAGL-YTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVT--VSEGEYVQ 8364

Query: 265  LTCEAIGKPQPVMVTWVRVDDEMP-----QHAVLSGPNLF-INNLNKTDNGTYRCEASNI 318
            L+C   G  +P+ + W++   E+        +  SG  +  + ++ K D+G Y C+ASN+
Sbjct: 8365 LSCHVQGS-EPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNV 8423

Query: 319  VGKAHSDYMLYVYDPPTTIP 338
             G   +   + + D P   P
Sbjct: 8424 AGSDTTKSKVTIKDKPAVAP 8443



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 70/311 (22%), Positives = 132/311 (42%), Gaps = 23/311 (7%)

Query: 62   ISCQVNKSDDSVIQLLNPNRQTI---YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISD 118
            +S  V + D + +Q+     + I   +F+D + L       ++ + +   + + +    D
Sbjct: 4586 VSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKD 4645

Query: 119  EGRYFCQLYTDPPQES----YTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPA 174
             G Y  ++  D  + S       + +++PP +    ++K  +++G  I++ C    S P 
Sbjct: 4646 SGEYTFEVQNDVGRSSCKARINVLDLIIPP-SFTKKLKKMDSIKGSFIDLECIVAGSHPI 4704

Query: 175  TTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ 234
            + I+WFK + E+   SE  ++S  +  T+ L +   +  D     C   + A  G+ Q  
Sbjct: 4705 S-IQWFKDDQEISA-SEKYKFS-FHDNTAFLEISQLEGTDSGTYTCSATNKA--GHNQCS 4759

Query: 235  RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS 294
             +L V+  P     +  P          ++L    +G   P+ + W + + E+   A  S
Sbjct: 4760 GHLTVKEPPYF---VEKPQSQDVNPNTRVQLKA-LVGGTAPMTIKWFKDNKELHSGAARS 4815

Query: 295  ------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTT 348
                    +L +     TD+GTY C+ SN VG A S   L+V +PP  I  P+       
Sbjct: 4816 VWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRN 4875

Query: 349  TTTTTILTIIT 359
              +TT    IT
Sbjct: 4876 GQSTTFECQIT 4886



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 62/312 (19%), Positives = 122/312 (39%), Gaps = 22/312 (7%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            +TV+ GE A +   +  +    +Q L    + I        ++S    + F  +   +  
Sbjct: 5619 LTVVAGEPAELQASIEGAQPIFVQWLKEKEEVI--------RESENIRITFVENVATLQF 5670

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMAS 171
                 ++ G+Y CQ+  D          +++ P  ++      T   GE   + C  +A 
Sbjct: 5671 AKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECK-VAG 5729

Query: 172  KPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNL 231
             P  ++ W+K   +L   S+  ++S    ++S  +L V ++D G     QV++     + 
Sbjct: 5730 TPELSVEWYKDG-KLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTF-QVQNNVGKSSC 5787

Query: 232  QTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA 291
                 +  +  P    +      G+   G +  L C+  G   P+ V W     ++   A
Sbjct: 5788 TAVVDVSDRAVPPSFTRRLKNTGGVL--GASCILECKVAGS-SPISVAWFHEKTKIVSGA 5844

Query: 292  VLSGP------NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI--PPPTTT 343
                        L +N+L+ +D G Y C A+N+ G      +L V +PP+ +  P P   
Sbjct: 5845 KYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEV 5904

Query: 344  TTTTTTTTTTIL 355
                  T T+++
Sbjct: 5905 LPGKNVTFTSVI 5916



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 72/307 (23%), Positives = 127/307 (41%), Gaps = 35/307 (11%)

Query: 46   NLFTKD-VTVIE----------GEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKD 94
            NLF K+  T +E          G+   ++C+V  +         P  +  +F + R +K+
Sbjct: 4292 NLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGT---------PPIKITWFANDREIKE 4342

Query: 95   SRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKD 154
            S    ++F  S   + LT+V I D G Y C+   +   +  ++I V+V          K 
Sbjct: 4343 SSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSI-VIVKESPYFTKEFKP 4401

Query: 155  TAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDD 214
              V  E   +    +A  P   I WFK NT L+   + + +   + V+ Q+ LK    D 
Sbjct: 4402 IEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQI-LKFVAADA 4460

Query: 215  GVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQ 274
            G    C+V +   +     +  L         I+ T  L+G T    A + T +      
Sbjct: 4461 G-EYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTA---AFQATLKG---SL 4513

Query: 275  PVMVTWVRVDDEMPQHAVL------SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYML 328
            P+ VTW++  DE+ +   +      +  +L+++ +    +G Y C+A N  G      +L
Sbjct: 4514 PITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573

Query: 329  YVYDPPT 335
             V +P T
Sbjct: 4574 SVKEPAT 4580



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 65/278 (23%), Positives = 117/278 (42%), Gaps = 20/278 (7%)

Query: 79   PNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTI 138
            P  + ++++D R L+ S+   +   +    + + NV  SD G Y C+   +   ++    
Sbjct: 5544 PPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCT 5603

Query: 139  TVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDM 198
              L  P   +  +   T V GE  E+  +   ++P   ++W K   E+  +SE    + +
Sbjct: 5604 VKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP-IFVQWLKEKEEVIRESENIRITFV 5662

Query: 199  YTVTSQLMLKVHKEDDGVPVICQVEHP-AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLT 257
              V +    K    + G   ICQ+++   +  N+ T   LE    P V ++   P+    
Sbjct: 5663 ENVATLQFAKAEPANAG-KYICQIKNDGGMRENMATLMVLE----PAVIVEKAGPM--TV 5715

Query: 258  REGDALELTCEAIGKPQPVMVTWVRVDDEM---PQHAVLSGPN----LFINNLNKTDNGT 310
              G+   L C+  G P+ + V W + D ++    Q    S  N    L I ++ + D GT
Sbjct: 5716 TVGETCTLECKVAGTPE-LSVEWYK-DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGT 5773

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTT 348
            Y  +  N VGK+    ++ V D    +PP  T     T
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSD--RAVPPSFTRRLKNT 5809



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 61/265 (23%), Positives = 111/265 (41%), Gaps = 28/265 (10%)

Query: 85   YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPP 144
            +FR  R L       + F  +  ++ L N+ IS  G Y C +  +  Q S TT   +  P
Sbjct: 5926 WFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEP 5985

Query: 145  RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ 204
               +  +   +   G+ I +  T   + P  ++ W K    +       E  ++ T    
Sbjct: 5986 AAFLKRLSDHSVEPGKSIILESTYTGTLP-ISVTWKKDGFNI----TTSEKCNIVTTEKT 6040

Query: 205  LMLKV--HKEDDGVPVICQVEHPA---VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTRE 259
             +L++    + D     C++E+ A   V G L +        +P   +    PL+     
Sbjct: 6041 CILEILNSTKRDAGQYSCEIENEAGRDVCGALVS------TLEPPYFVTELEPLEAAV-- 6092

Query: 260  GDALELTCEAIGKPQPVMVTWVRVDDEM---PQHAVLSGPN---LFINNLNKTDNGTYRC 313
            GD++ L C+  G P+ + V+W + D ++   P++      N   L  N +N  D+G Y C
Sbjct: 6093 GDSVSLQCQVAGTPE-ITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTC 6151

Query: 314  EASNIVGKAHSDYMLYVYD---PPT 335
            +A N +G A S  +  + +   PP+
Sbjct: 6152 KAENSIGTASSKTVFRIQERQLPPS 6176



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 66/310 (21%), Positives = 116/310 (37%), Gaps = 24/310 (7%)

Query: 54   VIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTN 113
            ++ GE A + C++  S         P  Q  +F++ + L +S    + F +SE  + +T+
Sbjct: 3749 MLPGESARLHCKLKGS---------PVIQVTWFKNNKELSESNTVRMYFVNSEAILDITD 3799

Query: 114  VSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKP 173
            V + D G Y C+   D   +S +T  V+  P + +  ++    V G    + C    + P
Sbjct: 3800 VKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGP 3859

Query: 174  ATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQT 233
               I WFK   +++   +   +S    V  ++    +  D G             G + T
Sbjct: 3860 -FEISWFKDKKQIRSSKKYRLFSQKSLVCLEI-FSFNSADVGEYECVVANEVGKCGCMAT 3917

Query: 234  QRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW------VRVDDEM 287
                E    P   ++    L  L  +   L+    A+   +P+ VTW      +R D ++
Sbjct: 3918 HLLKE----PPTFVKKVDDLIALGGQTVTLQ---AAVRGSEPISVTWMKGQEVIREDGKI 3970

Query: 288  PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTT 347
                      L I ++  +  G Y C A N  G   S   L V +P   I        T 
Sbjct: 3971 KMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTA 4030

Query: 348  TTTTTTILTI 357
                T   T+
Sbjct: 4031 GDPATLEYTV 4040



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 66/321 (20%), Positives = 123/321 (38%), Gaps = 56/321 (17%)

Query: 48   FTKDVTVIE---GEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSS 104
            FTK +T ++   G    + C+V+ S     Q         +F+D + +  S    L    
Sbjct: 5239 FTKKLTKMDKVLGSSIHMECKVSGSLPISAQ---------WFKDGKEISTSAKYRLVCHE 5289

Query: 105  SELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEV 164
              + + + N+ + D   Y C++      ++ + I  +  P + ++   +  A+    +E 
Sbjct: 5290 RSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEF 5349

Query: 165  NCTAMASKPATTIRWFKGNTELK-------GKSEVEEWSDMYTV----TSQLMLKVHKE- 212
                +   P   I+WFK + EL        G      + ++Y+V    T Q    V  + 
Sbjct: 5350 K-AILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDV 5408

Query: 213  --DDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAI 270
              D    ++   E P     L+  +                    + + GD+  L C+  
Sbjct: 5409 GSDSCTTMLLVTEPPKFVKKLEASK--------------------IVKAGDSSRLECKIA 5448

Query: 271  GKPQPVMVTWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHS 324
            G P+ + V W R + E+P         + S   + +NNL+  D+G + CEA N  G    
Sbjct: 5449 GSPE-IRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSC 5507

Query: 325  DYMLYVYDPP--TTIPPPTTT 343
               + V +PP  ++ PP   T
Sbjct: 5508 STKVIVKEPPVFSSFPPIVET 5528



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 60/257 (23%), Positives = 114/257 (44%), Gaps = 16/257 (6%)

Query: 85   YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPP 144
            +F+D   L       +    S   ++L +V  S  G+Y C +  D   +S TT+ ++  P
Sbjct: 5363 WFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEP 5422

Query: 145  RNLMIDIQKDTAVE-GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTS 203
               +  ++    V+ G+   + C  +A  P   + WF+   EL   S+    + + +V  
Sbjct: 5423 PKFVKKLEASKIVKAGDSSRLEC-KIAGSPEIRVVWFRNEHELPA-SDKYRMTFIDSVAV 5480

Query: 204  QLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAL 263
              M  +  ED G   IC+ ++PA + +  T+  ++   +P V    ++P    T +   +
Sbjct: 5481 IQMNNLSTEDSG-DFICEAQNPAGSTSCSTKVIVK---EPPVF--SSFPPIVETLKNAEV 5534

Query: 264  ELTCEAIGKPQPVMVTWVRVDDEM---PQHAVLS---GPNLFINNLNKTDNGTYRCEASN 317
             L CE  G P P  V W +   ++    ++ + S     ++ I N++ +D G Y C+A N
Sbjct: 5535 SLECELSGTP-PFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN 5593

Query: 318  IVGKAHSDYMLYVYDPP 334
             VG       + + +PP
Sbjct: 5594 EVGSDTCVCTVKLKEPP 5610



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 52/255 (20%), Positives = 103/255 (40%), Gaps = 22/255 (8%)

Query: 92   LKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDI 151
            +++S    ++F  +   + L +   S+ G+Y CQ+  D      + +  ++ P  ++   
Sbjct: 6592 IRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKP 6651

Query: 152  QKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHK 211
            +  T   G    + C    + P  + +WFK   EL   S+    + +  V S  +     
Sbjct: 6652 EPMTVTTGNPFALECVVTGT-PELSAKWFKDGRELSADSK-HHITFINKVASLKIPCAEM 6709

Query: 212  EDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIG 271
             D G+    +V++     N     ++  +  P   I+    +  +   G ++ L C   G
Sbjct: 6710 SDKGLYSF-EVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL--GASVVLECRVSG 6766

Query: 272  KPQPVMVTWVRVDDEMPQHAVLSGPN-----------LFINNLNKTDNGTYRCEASNIVG 320
               P+ V W +  +E     ++SGP            L ++ L  +D G Y C A+N+ G
Sbjct: 6767 SA-PISVGWFQDGNE-----IVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAG 6820

Query: 321  KAHSDYMLYVYDPPT 335
                  +L V +PP+
Sbjct: 6821 SDECSAVLTVQEPPS 6835



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 75/297 (25%), Positives = 121/297 (40%), Gaps = 32/297 (10%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            KDV    G      C++N S+           Q  +++D   LKD      +F  +   +
Sbjct: 7123 KDVHETLGFPVAFECRINGSEPL---------QVSWYKDGVLLKDDANLQTSFVHNVATL 7173

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVL----VPPRNLMIDIQKDTAVEGEEIEVN 165
             +     S  G+Y C         S +   +L    VPP   +  +  D A+ GE     
Sbjct: 7174 QILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLAL-GESGTFK 7232

Query: 166  CTAMASKPATTIRWFKGNTELK--GKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVE 223
            C    + P   I W K N E++  G  ++    +  T+T   +LKV K D G    C   
Sbjct: 7233 CHVTGTAPIK-ITWAKDNREIRPGGNYKMTLVENTATLT---VLKVGKGDAG-QYTCYAS 7287

Query: 224  HPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRV 283
            +  + G       L VQ  P+  I+   P + + ++ +     C+  G P+ + V W + 
Sbjct: 7288 N--IAGKDSCSAQLGVQEPPRF-IKKLEPSR-IVKQDEFTRYECKIGGSPE-IKVLWYKD 7342

Query: 284  DDEMPQHA------VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            + E+ + +      V S   L ++NL+  D+G Y CEA N  G A S   L V +PP
Sbjct: 7343 ETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 64/299 (21%), Positives = 121/299 (40%), Gaps = 32/299 (10%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            V  + GE AT+ C+V+ +         P  +  ++++   L+ +    + F ++   + +
Sbjct: 7029 VEAVIGEPATLQCKVDGT---------PEIRISWYKEHTKLRSAPAYKMQFKNNVASLVI 7079

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTTITVL----VPP--RNLMIDIQKDTAVEGEEIEVN 165
              V  SD G Y C+        + + + V+    +PP     + D+ +     G  +   
Sbjct: 7080 NKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETL---GFPVAFE 7136

Query: 166  CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP 225
            C    S+P   + W+K    LK  + ++  S ++ V +  +L+  +   G    C   +P
Sbjct: 7137 CRINGSEPLQ-VSWYKDGVLLKDDANLQT-SFVHNVATLQILQTDQSHIG-QYNCSASNP 7193

Query: 226  AVTGNLQTQRYL-EVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
              T +   +  L E +  P   ++   P+      G++    C   G   P+ +TW + +
Sbjct: 7194 LGTASSSAKLILSEHEVPPFFDLK---PVSVDLALGESGTFKCHVTGTA-PIKITWAKDN 7249

Query: 285  DEM------PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
             E+          V +   L +  + K D G Y C ASNI GK      L V +PP  I
Sbjct: 7250 REIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFI 7308



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 60/280 (21%), Positives = 111/280 (39%), Gaps = 16/280 (5%)

Query: 85   YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDP-PQESYTTITVLVP 143
            +F+D + L     + +    +   + L     +D G Y CQL  D     S  T+ V  P
Sbjct: 4801 WFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEP 4860

Query: 144  PRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTS 203
            P+ +           G+     C  +   P   + W+    E+    +           +
Sbjct: 4861 PQFIKKPSPVLVLRNGQSTTFECQ-ITGTPKIRVSWYLDGNEITAIQK--HGISFIDGLA 4917

Query: 204  QLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAL 263
               +   + ++    +C+  + A T +   +  L+V+ +P   I+   P++ + +  D +
Sbjct: 4918 TFQISGARVENSGTYVCEARNDAGTASCSIE--LKVK-EPPTFIRELKPVE-VVKYSD-V 4972

Query: 264  ELTCEAIGKPQPVMVTWVRVDDEMPQHAV------LSGPNLFINNLNKTDNGTYRCEASN 317
            EL CE  G P P  VTW++ + E+           +S  NL I   + +D G Y+C  SN
Sbjct: 4973 ELECEVTGTP-PFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSN 5031

Query: 318  IVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTI 357
              G       + + +PP+ I     TTT   ++ T   T+
Sbjct: 5032 EGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTV 5071



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 61/266 (22%), Positives = 110/266 (41%), Gaps = 20/266 (7%)

Query: 85   YFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPP 144
            +++D R L+  +   +   +    + + NV  +D G Y C+   D   ++      L  P
Sbjct: 7432 WYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAP 7491

Query: 145  RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ 204
               +  +   + V G+E+++  T   ++P + + WFK   E+  +S+    S    + + 
Sbjct: 7492 PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVV-WFKDKGEIVRESDNIWISYSENIATL 7550

Query: 205  LMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALE 264
               +V   + G    CQ+++ A  G  +    L V  +P   ++    ++  T  GD   
Sbjct: 7551 QFSRVEPANAG-KYTCQIKNDA--GMQECFATLSV-LEPATIVEKPESIKVTT--GDTCT 7604

Query: 265  LTCEAIGKPQPVMVTWVRVDDEMPQ--------HAVLSGPNLFINNLNKTDNGTYRCEAS 316
            L C   G P+ +   W +   E+             +SG  L I N+  +D+G Y  E  
Sbjct: 7605 LECTVAGTPE-LSTKWFKDGKELTSDNKYKISFFNKVSG--LKIINVAPSDSGVYSFEVQ 7661

Query: 317  NIVGKAHSDYMLYVYDPPTTIPPPTT 342
            N VGK      L V D   T+PP  T
Sbjct: 7662 NPVGKDSCTASLQVSD--RTVPPSFT 7685



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 66/315 (20%), Positives = 122/315 (38%), Gaps = 36/315 (11%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            V V  G+ A++ CQ+  +         P     +++    L+ +    ++F ++   +  
Sbjct: 7970 VKVSVGDSASLQCQLAGT---------PEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVF 8020

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTTITVL----VPP--RNLMIDIQKDTAVEGEEIEVN 165
              V I+D G Y C+      + S +T   +    +PP     + D+Q+     G  +  +
Sbjct: 8021 NQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV---GLPVVFD 8077

Query: 166  CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGV--PVICQVE 223
            C    S+P  ++ W+K    LK    V+      T T    L + K D  +     C   
Sbjct: 8078 CAISGSEP-ISVSWYKDGKPLKDSPNVQTSFLDNTAT----LNIFKTDRSLAGQYSCTAT 8132

Query: 224  HPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRV 283
            +P  + +   +  L     P        P+  +   G++ +  C   G  QP+ V+W + 
Sbjct: 8133 NPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV--GESADFECHVTG-TQPIKVSWAKD 8189

Query: 284  DDEMPQHA------VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
              E+          + +  +L +  ++K D+G Y C A N VGK      L + +    I
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKE--RLI 8247

Query: 338  PPPTTTTTTTTTTTT 352
            PP  T   + T   T
Sbjct: 8248 PPSFTKRLSETVEET 8262



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 62/293 (21%), Positives = 117/293 (39%), Gaps = 27/293 (9%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            + + V  G+  T+ C V  +         P   T +F+D + L       ++F +    +
Sbjct: 7593 ESIKVTTGDTCTLECTVAGT---------PELSTKWFKDGKELTSDNKYKISFFNKVSGL 7643

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEVNC 166
             + NV+ SD G Y  ++     ++S T    ++    P +    +++   + G  + + C
Sbjct: 7644 KIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703

Query: 167  TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA 226
                S P  ++ WF    E+    + +  + +   T  L + + +E D     C   + A
Sbjct: 7704 KVYGS-PPISVSWFHEGNEISSGRKYQ--TTLTDNTCALTVNMLEESDSGDYTCIATNMA 7760

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDE 286
              G+ +    L V+ +P   +Q   P+  LT  G  +  T    G P P  V+W +   E
Sbjct: 7761 --GSDECSAPLTVR-EPPSFVQKPDPMDVLT--GTNVTFTSIVKGTP-PFSVSWFKGSSE 7814

Query: 287  MPQ------HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDP 333
            +            S   L + +++ + +G Y C  SN  GKA     LY+  P
Sbjct: 7815 LVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAP 7867



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 56/291 (19%), Positives = 114/291 (39%), Gaps = 24/291 (8%)

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT 137
            +P  + ++++D   +++S    ++F  S   + + N+S+ D G Y C+ +      S +T
Sbjct: 7332 SPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391

Query: 138  ITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSD 197
               +  P            ++G ++ + C    + P   + W+K   EL+   + +  S+
Sbjct: 7392 SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFH-VSWYKDKRELRSGKKYKIMSE 7450

Query: 198  MYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLT 257
             + +TS  +L V   D G    C+  +   +        L+    P   ++    +  + 
Sbjct: 7451 NF-LTSIHILNVDAADIG-EYQCKATNDVGSDTCVGSIALKA---PPRFVKKLSDISTVV 7505

Query: 258  REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFIN-----------NLNKT 306
             +   L+ T E     +P+ V W +   E+    V    N++I+            +   
Sbjct: 7506 GKEVQLQTTIEGA---EPISVVWFKDKGEI----VRESDNIWISYSENIATLQFSRVEPA 7558

Query: 307  DNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTI 357
            + G Y C+  N  G       L V +P T +  P +   TT  T T   T+
Sbjct: 7559 NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTV 7609



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 54/258 (20%), Positives = 105/258 (40%), Gaps = 16/258 (6%)

Query: 100  LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEG 159
            + F ++   + L+ + +  +G+Y CQ   D   +  + +  +  P  +  +       +G
Sbjct: 4534 MTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQG 4593

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
            +   +      +K  T  +WFK   EL   S+  + S   TV+   ++   K+D G    
Sbjct: 4594 DPATLQVKFSGTKEITA-KWFKDGQELTLGSKY-KISVTDTVSILKIISTEKKDSG-EYT 4650

Query: 220  CQVEHPAVTGNLQTQ-RYLEVQYKPQVHIQMTYPLQGL-TREGDALELTCEAIGKPQPVM 277
             +V++     + + +   L++   P      T  L+ + + +G  ++L C   G   P+ 
Sbjct: 4651 FEVQNDVGRSSCKARINVLDLIIPP----SFTKKLKKMDSIKGSFIDLECIVAGS-HPIS 4705

Query: 278  VTWVRVDDEMPQHAVL------SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
            + W + D E+            +   L I+ L  TD+GTY C A+N  G       L V 
Sbjct: 4706 IQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK 4765

Query: 332  DPPTTIPPPTTTTTTTTT 349
            +PP  +  P +      T
Sbjct: 4766 EPPYFVEKPQSQDVNPNT 4783



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 56/270 (20%), Positives = 105/270 (38%), Gaps = 14/270 (5%)

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT 137
            +P     + +D + L +     ++F  S   + + +V     GRY CQ   +   E    
Sbjct: 5074 SPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYA 5133

Query: 138  ITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSD 197
              ++  P  ++   +     E + + + C  +A  P   ++W K   ++   S     S 
Sbjct: 5134 FLLVQEPAQIVEKAKSVDVTEKDPMTLECV-VAGTPELKVKWLKDGKQIV-PSRYFSMSF 5191

Query: 198  MYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQ-RYLEVQYKPQVHIQMTYPLQGL 256
               V S  +  V K+D G     +VE+   + +     R L+    P    ++T   + L
Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTF-KVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL 5250

Query: 257  TREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS------GPNLFINNLNKTDNGT 310
               G ++ + C+  G   P+   W +   E+   A           +L +NNL   D   
Sbjct: 5251 ---GSSIHMECKVSGS-LPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTAN 5306

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPP 340
            Y C+ SN+ G      +L V +PP+ +  P
Sbjct: 5307 YTCKVSNVAGDDACSGILTVKEPPSFLVKP 5336



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 51/300 (17%)

Query: 65   QVNKSDDSVIQLL---NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGR 121
            QV   D + ++      P  +  +++D RPL  S+   ++F ++  ++   +  + D G+
Sbjct: 4027 QVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQ 4086

Query: 122  YFCQLYTDPPQESY-TTITVL---------VPPRNLMIDIQKDTAVEGEEIEVNCTAMAS 171
            Y  ++  +    S  TT TVL          P RN+      D+ V G    ++C    S
Sbjct: 4087 YTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNV------DSVVNGT-CRLDCKIAGS 4139

Query: 172  KPATTIRWFKGNTELKGKSEVEEWSDMYTVT------SQLMLKVHKEDDGVPVICQVEHP 225
             P   + WFK   E+         SD Y +       S  +++V   D G    C+  + 
Sbjct: 4140 LPMR-VSWFKDGKEIAA-------SDRYRIAFVEGTASLEIIRVDMNDAG-NFTCRATNS 4190

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDD 285
               G+  +   L VQ  P     +T P       G A+ L     G   P+ + W + + 
Sbjct: 4191 V--GSKDSSGALIVQEPPSF---VTKPGSKDVLPGSAVCLKSTFQGST-PLTIRWFKGNK 4244

Query: 286  EM--------PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
            E+         + A+ S   L++  +  +D+GTY C+ SN+ G       L+V +P T +
Sbjct: 4245 ELVSGGSCYITKEALESSLELYL--VKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFV 4302



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 70/307 (22%), Positives = 119/307 (38%), Gaps = 34/307 (11%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            K V V++     + C+V  +    +  L  NR+         ++ S+   L    S   +
Sbjct: 4962 KPVEVVKYSDVELECEVTGTPPFEVTWLKNNRE---------IRSSKKYTLTDRVSVFNL 5012

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
             +T    SD G Y C +  +    S +T   L  P + +  I+  T V         T +
Sbjct: 5013 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQST-V 5071

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYT--VTSQLMLKVHKEDDGVP--VICQVEHP 225
            A  P  +I W      LK    ++E  ++Y   V S   L++   D+G      CQ ++ 
Sbjct: 5072 AGSPPISITW------LKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNE 5125

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDD 285
              +G  +   +L VQ   Q+ ++    +     E D + L C   G P+ + V W++   
Sbjct: 5126 --SGVERCYAFLLVQEPAQI-VEKAKSVD--VTEKDPMTLECVVAGTPE-LKVKWLKDGK 5179

Query: 286  EMPQHAVLS------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
            ++      S        +  I ++ K D+G Y  +  N  G +  D  L V D    IPP
Sbjct: 5180 QIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLD--QNIPP 5237

Query: 340  PTTTTTT 346
              T   T
Sbjct: 5238 SFTKKLT 5244



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 66/317 (20%), Positives = 123/317 (38%), Gaps = 36/317 (11%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            +DV    G      C ++ S+   +          +++D +PLKDS     +F  +   +
Sbjct: 8064 RDVQETVGLPVVFDCAISGSEPISVS---------WYKDGKPLKDSPNVQTSFLDNTATL 8114

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRN---LMIDIQKDTAVEGEEIEVNC 166
            ++     S  G+Y C         S +   +L   +N     I +    AV GE  +  C
Sbjct: 8115 NIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFEC 8174

Query: 167  TAMASKPATTIRWFKGNTELK--GKSEVEEWSDMYTVTSQLMLKVHKEDDG---VPVICQ 221
                ++P   + W K + E++  GK ++    +   +T   +LKV K D G      + +
Sbjct: 8175 HVTGTQP-IKVSWAKDSREIRSGGKYQISYLENSAHLT---VLKVDKGDSGQYTCYAVNE 8230

Query: 222  VEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWV 281
            V   + T  L  +  L     P    +++  ++    EG++ +L     G  QP+ V W 
Sbjct: 8231 VGKDSCTAQLNIKERL---IPPSFTKRLSETVE--ETEGNSFKLEGRVAGS-QPITVAWY 8284

Query: 282  R--VDDEMPQHAVLSGPN----LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            +  ++ +   +  ++  N    L +      D G Y C+ SN  G A     + + +P  
Sbjct: 8285 KNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK- 8343

Query: 336  TIPPPTTTTTTTTTTTT 352
               PP      T  T +
Sbjct: 8344 --KPPVFDQHLTPVTVS 8358



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 59/253 (23%), Positives = 101/253 (39%), Gaps = 28/253 (11%)

Query: 100  LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV-- 157
            + F ++ L + +    ++D G Y C++  D      T+  V+  P+   +  Q  T V  
Sbjct: 8298 ITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTV 8357

Query: 158  -EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGV 216
             EGE ++++C    S+P   I+W K   E+K            + T+ L L+   + D  
Sbjct: 8358 SEGEYVQLSCHVQGSEPIR-IQWLKAGREIKPSDRCS--FSFASGTAVLELRDVAKADSG 8414

Query: 217  PVICQVEHPAVTGNLQTQRYLEVQYKPQVH------------IQMTYPLQGLTREGDALE 264
              +C+  +  V G+  T+  + ++ KP V               ++ P      E     
Sbjct: 8415 DYVCKASN--VAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472

Query: 265  LTCEAIGKPQPVMVTWVRVD-DEMPQ------HAVLSGPNLFINNLNKTDNGTYRCEASN 317
               +  G P P  V W +    ++ Q      H       L I +  KTD+G YRC A N
Sbjct: 8473 FIAKVGGDPIP-NVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFN 8531

Query: 318  IVGKAHSDYMLYV 330
              G+  S+  L V
Sbjct: 8532 EHGEIESNVNLQV 8544



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 63/291 (21%), Positives = 118/291 (40%), Gaps = 32/291 (10%)

Query: 57   GEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSI 116
            G+  ++ CQV  + +  +     + +       RP  + R     F+++   +    V+I
Sbjct: 6093 GDSVSLQCQVAGTPEITVSWYKGDTK------LRPTPEYRTY---FTNNVATLVFNKVNI 6143

Query: 117  SDEGRYFCQLYTDPPQESYTTITVL----VPPR--NLMIDIQKDTAVEGEEIEVNCTAMA 170
            +D G Y C+        S  T+  +    +PP     + DI++     G  + + C    
Sbjct: 6144 NDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTV---GLPVTLTCRLNG 6200

Query: 171  SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGN 230
            S P   + W++    L+    ++  S +  V +  +L+      G    C   +P  T +
Sbjct: 6201 SAPIQ-VCWYRDGVLLRDDENLQT-SFVDNVATLKILQTDLSHSG-QYSCSASNPLGTAS 6257

Query: 231  LQTQRYL-EVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQ 289
               +    E +  P   I+   P+      G++ +  C   G  QP+ +TW + + E+  
Sbjct: 6258 SSARLTAREPKKSPFFDIK---PVSIDVIAGESADFECHVTGA-QPMRITWSKDNKEIRP 6313

Query: 290  HA------VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
                    V + P+L I  + K D+G Y C+A+N VGK      L V +PP
Sbjct: 6314 GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPP 6364



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 51/269 (18%), Positives = 106/269 (39%), Gaps = 22/269 (8%)

Query: 100  LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEG 159
            ++   S  ++ L +V  S  G Y C +  +  + S TT   +  P   +  +   +  +G
Sbjct: 7823 VSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKG 7882

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKE--DDGVP 217
            + + +  T     P  ++ W K    +          ++ T     +L++     +D   
Sbjct: 7883 KPLILEGT-FTGTPPISVTWKKNGINVTPSQRC----NITTTEKSAILEIPSSTVEDAGQ 7937

Query: 218  VICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVM 277
              C +E+ +   +   Q  +    +P   ++   P++     GD+  L C+  G P+ + 
Sbjct: 7938 YNCYIENASGKDSCSAQILI---LEPPYFVKQLEPVK--VSVGDSASLQCQLAGTPE-IG 7991

Query: 278  VTWVRVDDEM------PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
            V+W + D ++        H   +   L  N ++  D+G Y C+A N VG+  +   L V 
Sbjct: 7992 VSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051

Query: 332  DPPTTIPPPTTTTTTTTTTTTTILTIITD 360
            +      PP+ +        T  L ++ D
Sbjct: 8052 EQKL---PPSFSRQLRDVQETVGLPVVFD 8077



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 12/127 (9%)

Query: 237   LEVQYKPQVHIQMTYPLQGLT-REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSG 295
             ++ Q  P++ + +   L GLT + G  +EL     GKP+P  +TW + D  + Q   ++ 
Sbjct: 13682 VDTQEAPEIFLDVKL-LAGLTVKAGTKIELPATVTGKPEP-KITWTKADMILKQDKRITI 13739

Query: 296   PNL------FINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTT 349
              N+       I +  ++D GTY  EA N+ G+A +   + V D P    PP     T  T
Sbjct: 13740 ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP---GPPAAFDITDVT 13796

Query: 350   TTTTILT 356
               + +LT
Sbjct: 13797 NESCLLT 13803



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/190 (26%), Positives = 78/190 (41%), Gaps = 27/190 (14%)

Query: 159   GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
             GE  +++C  +  +P   I+W++   EL    + +  SD  T T  +M +  +ED+GV  
Sbjct: 30547 GEAAQLSCQ-IVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE-EQEDEGVYT 30604

Query: 219   ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQG--LTREGDALELTCEAIGKPQPV 276
                       G ++T   L +Q  PQ H    YPL+       G  L L    IG+P P 
Sbjct: 30605 CIATNE---VGEVETSSKLLLQATPQFH--PGYPLKEKYYGAVGSTLRLHVMYIGRPVPA 30659

Query: 277   MVTWVRVDDEMPQHAVLSGPNLFINNLN------------KTDNGTYRCEASNIVGKAHS 324
             M TW        Q  + +  N+ I N              KT  G Y+ + SN+ G   +
Sbjct: 30660 M-TWFH-----GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDA 30713

Query: 325   DYMLYVYDPP 334
                + + D P
Sbjct: 30714 ILDVEIQDKP 30723



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 5/100 (5%)

Query: 258   REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN----LFINNLNKTDNGTYRC 313
             R G +L L     G+P PV +TW +   ++   A++        L ++ +N+ D G Y  
Sbjct: 29459 RAGASLRLMVSVSGRPPPV-ITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 29517

Query: 314   EASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTT 353
             EA N  GK  +  ++ VYD P   P       +  + T T
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTIT 29557



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 54/282 (19%), Positives = 105/282 (37%), Gaps = 16/282 (5%)

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT 137
            +P  + ++FR+   L  S    + F  S   + + N+S  D G + C+        S +T
Sbjct: 5450 SPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST 5509

Query: 138  ITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSD 197
              ++  P            ++  E+ + C  ++  P   + W+K   +L+   + +  S 
Sbjct: 5510 KVIVKEPPVFSSFPPIVETLKNAEVSLEC-ELSGTPPFEVVWYKDKRQLRSSKKYKIASK 5568

Query: 198  MYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLT 257
             +  TS  +L V   D G    C+ ++   +        L+   +P   +     L  + 
Sbjct: 5569 NFH-TSIHILNVDTSDIG-EYHCKAQNEVGSDTCVCTVKLK---EPPRFVSKLNSLTVVA 5623

Query: 258  REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA-------VLSGPNLFINNLNKTDNGT 310
             E   L+ + E     QP+ V W++  +E+ + +       V +   L        + G 
Sbjct: 5624 GEPAELQASIEG---AQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGK 5680

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTT 352
            Y C+  N  G   +   L V +P   +      T T   T T
Sbjct: 5681 YICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCT 5722



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 36/137 (26%), Positives = 59/137 (43%), Gaps = 15/137 (10%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            +DVT+ EG+  T++CQ +           PN ++ +FR+ R LK              K+
Sbjct: 8752 QDVTLKEGQTCTMTCQFSV----------PNVKSEWFRNGRILKPQGRHKTEVEHKVHKL 8801

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            ++ +V   D+G+Y C+ Y D   E+   + +   P      IQ     E +     C   
Sbjct: 8802 TIADVRAEDQGQYTCK-YED--LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECE-- 8856

Query: 170  ASKPATTIRWFKGNTEL 186
             S     + W+KG TEL
Sbjct: 8857 VSFDDAIVTWYKGPTEL 8873



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/202 (22%), Positives = 79/202 (39%), Gaps = 22/202 (10%)

Query: 50    KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
             +D TV EGE AT  C          +L +     ++F++   L  SR  L++      K+
Sbjct: 11581 EDQTVKEGETATFVC----------ELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKL 11630

Query: 110   SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
              +  V++ D  +   Q+       S   + VL       + +   TAVE +EI + C   
Sbjct: 11631 EMKEVTLDDISQIKAQV---KELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVS 11687

Query: 170   ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKED--DGVPVICQVEHPAV 227
                P   ++WFK   E+    +    +D      + +LK+ K D  D    +C       
Sbjct: 11688 KDVP---VKWFKDGEEIVPSPKYSIKAD----GLRRILKIKKADLKDKGEYVCDCGTDKT 11740

Query: 228   TGNLQTQRYLEVQYKPQVHIQM 249
               N+  +  L    KP   +++
Sbjct: 11741 KANVTVEARLIKVEKPLYGVEV 11762



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 11/138 (7%)

Query: 223   EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
             EH  V G +  +  LE    P + + +        R G +L L     G+P P  V W +
Sbjct: 22923 EHADVPGPIIVEEKLEA---PDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPE-VKWGK 22978

Query: 283   VDDEMPQHAVL----SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
             VD E+   A++    S  +L ++N+N+ D+G Y     N  G   +   + V D P+   
Sbjct: 22979 VDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPS--- 23035

Query: 339   PPTTTTTTTTTTTTTILT 356
             PP     T  T  +  +T
Sbjct: 23036 PPVNLKVTEITKDSVSIT 23053



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 10/105 (9%)

Query: 243   PQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQ------HAVLSGP 296
             P++ ++  Y    + + GD +++    +G+P+P  VTW + D  + Q          +  
Sbjct: 21063 PELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPT-VTWKKGDQILKQTQRVNFETTATST 21121

Query: 297   NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPT 341
              L IN   ++D+G Y   A NIVG+      + V+D P    PPT
Sbjct: 21122 ILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIP---GPPT 21163



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 59/295 (20%), Positives = 105/295 (35%), Gaps = 27/295 (9%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            +TV  G    + C V  +         P     +F+D R L       + F +    + +
Sbjct: 6654 MTVTTGNPFALECVVTGT---------PELSAKWFKDGRELSADSKHHITFINKVASLKI 6704

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTT---ITVLVPPRNLMIDIQKDTAVEGEEIEVNCTA 168
                +SD+G Y  ++     + + T    ++  + P + +  ++   A+ G  + + C  
Sbjct: 6705 PCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRV 6764

Query: 169  MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVT 228
              S P + + WF+   E+    + +        T  L L +   D G+          V 
Sbjct: 6765 SGSAPIS-VGWFQDGNEIVSGPKCQSSFSENVCTLNLSL-LEPSDTGIYTCVAAN---VA 6819

Query: 229  GNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEM- 287
            G+ +    L VQ  P        P       G +L  T    G P P  V W +   E+ 
Sbjct: 6820 GSDECSAVLTVQEPPSFE---QTPDSVEVLPGMSLTFTSVIRGTP-PFKVKWFKGSRELV 6875

Query: 288  PQHAVLSGPNLFINNLN-----KTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
            P  +       F+  L        ++G Y C  +N  G A     L+V +P T +
Sbjct: 6876 PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFV 6930



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 72/324 (22%), Positives = 118/324 (36%), Gaps = 41/324 (12%)

Query: 50    KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
             KDVTV  GE AT  C+++  D  V   L   +          L+ S   +         +
Sbjct: 12203 KDVTVTAGETATFDCELSYEDIPVEWYLKGKK----------LEPSDKVVPRSEGKVHTL 12252

Query: 110   SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
             +L +V + D G    QL T    +++  + V  PP      ++  T  EG    + C   
Sbjct: 12253 TLRDVKLEDAGE--VQL-TAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECE-- 12307

Query: 170   ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
              S+    ++WFK  TE+    + E  +D      +L++     +D     C  +    + 
Sbjct: 12308 VSRENAKVKWFKNGTEILKSKKYEIVAD--GRVRKLVIHDCTPEDIKTYTCDAKDFKTSC 12365

Query: 230   NLQTQRYLEVQYKPQVHIQMTYPLQGL-TREGDALELTCEAIGKPQPVMVTWVRVDDEM- 287
             NL              H++   PL  L  RE +     CE     +   V W +   E+ 
Sbjct: 12366 NLNV---------VPPHVEFLRPLTDLQVREKEMARFECEL--SRENAKVKWFKDGAEIK 12414

Query: 288   --PQHAVLSGPNLFINNLNK---TDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTT 342
                ++ ++S   + I  +NK    D   Y CE    V  A +  ML V +          
Sbjct: 12415 KGKKYDIISKGAVRILVINKCLLDDEAEYSCE----VRTARTSGMLTVLEEEAVF--TKN 12468

Query: 343   TTTTTTTTTTTILTIITDSRAGEE 366
                   + T TI  +   S+ G E
Sbjct: 12469 LANIEVSETDTIKLVCEVSKPGAE 12492



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 8/105 (7%)

Query: 256   LTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVL----SGPNLFINNLNKTDNGTY 311
             + + G +  +T    G+P P  V W + D ++   A +    S  +L I N N+ D+G Y
Sbjct: 26197 IVKAGASFTMTVPFRGRPVP-NVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKY 26255

Query: 312   RCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
                  N++  A    ++ V D P    PPT  T    T  + +L+
Sbjct: 26256 TLTIQNVLSAASLTLVVKVLDTP---GPPTNITVQDVTKESAVLS 26297



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 7/98 (7%)

Query: 256   LTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA------VLSGPNLFINNLNKTDNG 309
             + + G++L +     G+P P  VTW +   E+ +        VL   +LF+ +  +   G
Sbjct: 27969 IIKSGESLRIKALVQGRPVP-RVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 28027

Query: 310   TYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTT 347
              Y  EA N  G A ++  + V D P  +  P   T  T
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNIT 28065



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 60/297 (20%), Positives = 114/297 (38%), Gaps = 26/297 (8%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            KDV  I G    + C+V+ S    +          +F+D   +        +FS +   +
Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVG---------WFQDGNEIVSGPKCQSSFSENVCTL 6798

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +L+ +  SD G Y C        +  + +  +  P +          + G  +    + +
Sbjct: 6799 NLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVI 6857

Query: 170  ASKPATTIRWFKGNTEL-KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVT 228
               P   ++WFKG+ EL  G+S      D   VT   + +V   + G    C V + A +
Sbjct: 6858 RGTPPFKVKWFKGSRELVPGESCNISLEDF--VTELELFEVQPLESG-DYSCLVTNDAGS 6914

Query: 229  GNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMP 288
             +  T  +++   +P   ++        T  G  + L     G P P+ V+W++ +  + 
Sbjct: 6915 ASCTTHLFVK---EPATFVKRLADFSVET--GSPIVLEATYTGTP-PISVSWIKDEYLIS 6968

Query: 289  QHA----VLSGPNLFINNLNKT--DNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
            Q       ++  +  +  L  T  D   Y C   N  G+   + ++ V +PP  I P
Sbjct: 6969 QSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEP 7025



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 50/240 (20%), Positives = 94/240 (39%), Gaps = 27/240 (11%)

Query: 131   PQESYTTITVLVPPRNLMI-DIQKDT--------AVEGEEIEVNCTAMASKPATTIRWFK 181
             P E    I    PPRN+ I DI K++        A +G   ++    +  +     RW K
Sbjct: 26758 PSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGS-KITGYIVERRDLPDGRWTK 26816

Query: 182   GNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA-VTGNLQTQRYLEVQ 240
              +      +E +      T  SQ   +V   +     +  + +P+ V G +     ++  
Sbjct: 26817 AS--FTNVTETQFIISGLTQNSQYEFRVFARN----AVGSISNPSEVVGPITC---IDSY 26867

Query: 241   YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN--- 297
               P + + + Y      R G +++L     GKP P  + W + D E+  +A++   N   
Sbjct: 26868 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPT-IEWYKDDKELQTNALVCVENTTD 26926

Query: 298   ---LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTI 354
                + I + ++ ++G Y  +  N +G A +   + + D P     P    T T    T +
Sbjct: 26927 LASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLL 26986



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 47/209 (22%), Positives = 78/209 (37%), Gaps = 30/209 (14%)

Query: 171   SKPATTIRW----FKGNTELKG------KSEVEEWSDM---------YTVTSQLMLKVHK 211
             SK   ++ W    F G  E+ G      K+++ +W  +         YTVT     + +K
Sbjct: 28266 SKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYK 28325

Query: 212   -EDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAI 270
                  +    + +   VTG ++    L     P++ I   +    + R G ++ L     
Sbjct: 28326 FRVSAINGAGKGDSCEVTGTIKAVDRLTA---PELDIDANFKQTHVVRAGASIRLFIAYQ 28382

Query: 271   GKPQPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDY 326
             G+P P  V W + D  +      H   S   L + N N+ D G Y     N  G     +
Sbjct: 28383 GRPTPTAV-WSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITF 28441

Query: 327   MLYVYDPPTTIPPPTTTTTTTTTTTTTIL 355
              + V D P   PP   T    T  + T++
Sbjct: 28442 TVKVLDTPG--PPGPITFKDVTRGSATLM 28468



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 35/163 (21%), Positives = 65/163 (39%), Gaps = 11/163 (6%)

Query: 174   ATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQT 233
             A  +  FK  +E++  S V E     T T + +               +E  ++     T
Sbjct: 32493 AYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK-ST 32551

Query: 234   QRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR---VDDEMPQH 290
              R ++     ++   +T P      EG++   +C+  G+P P  VTW+R   V     +H
Sbjct: 32552 TRKIKTTLAARI---LTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 32607

Query: 291   AVLS---GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
              V +        I+++  +D G Y     N  GK  +++ L +
Sbjct: 32608 QVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 32650



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 49/249 (19%), Positives = 95/249 (38%), Gaps = 16/249 (6%)

Query: 100  LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEG 159
            ++FS+    + + +V IS  G+Y C    +   ++     ++  P  ++   +      G
Sbjct: 3972 MSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAG 4031

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
            +   +  T +A  P    +W+K    L    +           +QL     +  D     
Sbjct: 4032 DPATLEYT-VAGTPELKPKWYKDGRPLVASKKYR--ISFKNNVAQLKFYSAELHDSGQYT 4088

Query: 220  CQVEHPAVTGNLQTQ-RYLEVQYKPQVHIQMTYPLQGLTRE-GDALELTCEAIGKPQPVM 277
             ++ +   + + +T    L+    P      T PL+ +         L C+  G   P+ 
Sbjct: 4089 FEISNEVGSSSCETTFTVLDRDIAPF----FTKPLRNVDSVVNGTCRLDCKIAGS-LPMR 4143

Query: 278  VTWVRVDDEMPQH-----AVLSGP-NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
            V+W +   E+        A + G  +L I  ++  D G + C A+N VG   S   L V 
Sbjct: 4144 VSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQ 4203

Query: 332  DPPTTIPPP 340
            +PP+ +  P
Sbjct: 4204 EPPSFVTKP 4212



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 25/116 (21%), Positives = 48/116 (41%), Gaps = 7/116 (6%)

Query: 243   PQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS------GP 296
             P++ +   Y    +   G++ ++  +  GKP P  + W++ D E+   A L         
Sbjct: 22541 PRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT-IQWIKGDQELSNTARLEIKSTDFAT 22599

Query: 297   NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTT 352
             +L + +  + D+G Y  +A N+ G+      + V D P     P   +  T    T
Sbjct: 22600 SLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT 22655



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 7/88 (7%)

Query: 257   TREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN------LFINNLNKTDNGT 310
             T+ G+A +L+C+ +G+P P  + W R   E+ Q       +      L +    + D G 
Sbjct: 30544 TKLGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGV 30602

Query: 311   YRCEASNIVGKAHSDYMLYVYDPPTTIP 338
             Y C A+N VG+  +   L +   P   P
Sbjct: 30603 YTCIATNEVGEVETSSKLLLQATPQFHP 30630



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 70/292 (23%), Positives = 113/292 (38%), Gaps = 32/292 (10%)

Query: 57   GEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSI 116
            G +A  +C++  + +   Q     R+ IY  D   ++ S++       S L++  T V  
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGRE-IYESDKCSIRSSKY------ISSLEILRTQVV- 3521

Query: 117  SDEGRYFCQLYTDPPQESYT---TITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKP 173
             D G Y C+   +    S T   T+T   PP  L       T V G+  +  CT   +  
Sbjct: 3522 -DCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFV-GKAAKFICTVTGTPV 3579

Query: 174  ATTIRWFKGNTELKGKSEVEEW--SDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNL 231
              TI W K    L   S    W  SD        +  +  +D GV   C+  +       
Sbjct: 3580 IETI-WQKDGAAL---SPSPNWRISDAENKHILELSNLTIQDRGV-YSCKASNKFGADIC 3634

Query: 232  QTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA 291
            Q +  L +  KP   I+   P+Q    +   + L C+ + + + V VTW +   ++P   
Sbjct: 3635 QAE--LIIIDKPHF-IKELEPVQSAINK--KVHLECQ-VDEDRKVTVTWSKDGQKLPPGK 3688

Query: 292  VLSG------PNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
                        L I      D+GTY C ASN  G +     + V +PP+ +
Sbjct: 3689 DYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFV 3740



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 9/120 (7%)

Query: 243   PQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS------GP 296
             P++ + + +    + + G+A  L  +  G+P P M  W +   E+   A L         
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTM-EWSKDGKELEGTAKLEIKIADFST 21517

Query: 297   NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
             NL   +  + D+G Y   A+N  G A   + + V D P   PP      T  T+   +L+
Sbjct: 21518 NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPG--PPEGPLAVTEVTSEKCVLS 21575



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 29/103 (28%), Positives = 41/103 (39%), Gaps = 9/103 (8%)

Query: 260   GDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN------LFINNLNKTDNGTYRC 313
             G+   L  +  GKP P  + W+R D E+ + A     N      L + +  + D G Y  
Sbjct: 23640 GETFRLEADVHGKPLPT-IEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYIL 23698

Query: 314   EASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
              ASN+ G       + V D P   PP      T  T+    LT
Sbjct: 23699 RASNVAGSKSFPVNVKVLDRPG--PPEGPVQVTGVTSEKCSLT 23739



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 43/191 (22%), Positives = 71/191 (37%), Gaps = 24/191 (12%)

Query: 171   SKPATTIRWFK----GNTELKG--------KSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
             +K + T+ W      G  ++ G        +   + W++ Y+V   L L V    +G   
Sbjct: 18811 TKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE-YSVVKDLSLVVTGLKEGKKY 18869

Query: 219   ICQVEHPAVTGNLQTQRYLEVQYKPQVHI---QMTYPLQGLTREGDALELTCEAIGKPQP 275
               +V      G +   R  E  Y+ +  +   ++  P Q   + G  L +     GKP P
Sbjct: 18870 KFRVAARNAVG-VSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHP 18928

Query: 276   VMVTWVRVDDE------MPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
                 W + +DE      +  H   S   L I ++ + D+G Y   A N  G       + 
Sbjct: 18929 TC-KWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVV 18987

Query: 330   VYDPPTTIPPP 340
             V D P    PP
Sbjct: 18988 VMDAPGPPQPP 18998



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 51/257 (19%), Positives = 99/257 (38%), Gaps = 36/257 (14%)

Query: 106  ELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVE-GEEIEV 164
            E  + L  V  SD G Y C++         +    +  P   +  ++    ++ G+  ++
Sbjct: 4260 ESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQL 4319

Query: 165  NCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEH 224
             C    + P   I WF  + E+K  S+    S + +     +  V  ED G   +C+ ++
Sbjct: 4320 ACKVTGTPPIK-ITWFANDREIKESSK-HRMSFVESTAVLRLTDVGIEDSG-EYMCEAQN 4376

Query: 225  PAVTGN------LQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMV 278
             A + +      ++   Y   ++KP + +   Y +           L  E  G P P  +
Sbjct: 4377 EAGSDHCSSIVIVKESPYFTKEFKP-IEVLKEYDVM----------LLAEVAGTP-PFEI 4424

Query: 279  TWVRVDDEM----------PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYML 328
            TW + +  +            H V    +L I      D G Y+C  +N VG +     +
Sbjct: 4425 TWFKDNTILRSGRKYKTFIQDHLV----SLQILKFVAADAGEYQCRVTNEVGSSICSARV 4480

Query: 329  YVYDPPTTIPPPTTTTT 345
             + +PP+ I    +T++
Sbjct: 4481 TLREPPSFIKKIESTSS 4497



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 57/271 (21%), Positives = 106/271 (39%), Gaps = 41/271 (15%)

Query: 51    DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSR-FQLLNFSSSELKV 109
             D+ V E E+A   C++++           N +  +F+D   +K  + + +++  +  + V
Sbjct: 12382 DLQVREKEMARFECELSRE----------NAKVKWFKDGAEIKKGKKYDIISKGAVRILV 12431

Query: 110   SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
              +    + DE  Y C++ T     +   +TVL        ++      E + I++ C   
Sbjct: 12432 -INKCLLDDEAEYSCEVRT---ARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEV- 12486

Query: 170   ASKPATTIRWFKGNTEL--KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAV 227
              SKP   + W+KG+ E+   G+ E+        +  Q     H ED G    C++     
Sbjct: 12487 -SKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQ---NAHLEDAG-NYNCRLPSSRT 12541

Query: 228   TGNLQTQRY-LEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDE 286
              G ++      E   KPQ ++++         EG+  E  C    +  PV   W R D  
Sbjct: 12542 DGKVKVHELAAEFISKPQ-NLEIL--------EGEKAEFVCSISKESFPVQ--WKRDDKT 12590

Query: 287   MPQ----HAVLSGPN--LFINNLNKTDNGTY 311
             +        +  G    L + +    D GTY
Sbjct: 12591 LESGDKYDVIADGKKRVLVVKDATLQDMGTY 12621



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 56/293 (19%), Positives = 110/293 (37%), Gaps = 37/293 (12%)

Query: 56    EGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVS 115
             EG+    +C+++           P+ +  +F++  P+  S    ++ S +   + + N S
Sbjct: 33147 EGQNVLFTCEISGE---------PSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 33197

Query: 116   ISDEGRYFCQLYTDPPQESYTTITVLV-----PPRNLMIDIQKDTAVEGEEIEVNCTAMA 170
             +SD G+Y  +      Q S T   +++     P R +++    DT+++G     +    A
Sbjct: 33198 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSA 33257

Query: 171   SKPATTIRWFKGN-----TELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP 225
             SK   +   F  +     TE+K  S   +   M ++    +        G+  + Q+E  
Sbjct: 33258 SKQEASFSSFSSSSASSMTEMKFASMSAQ--SMSSMQESFVEMSSSSFMGISNMTQLES- 33314

Query: 226   AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW----- 280
                    T + L+   +         P      EG  L + C   G+P P  VTW     
Sbjct: 33315 ------STSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGR 33367

Query: 281   -VRVDDEMPQHAVLSG--PNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
              +   ++   H   +     L I ++ K D G Y     N  G   +   +++
Sbjct: 33368 KIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 64/305 (20%), Positives = 113/305 (37%), Gaps = 35/305 (11%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            K+V VIE + A +  +VN+ D              +++D   +    FQ+       ++ 
Sbjct: 3154 KEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEIN---FQVQERHKYVVER 3200

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLV---PPRNLMIDIQKDTAVEGEEIEVNC 166
             +  + IS+  +     YT     + +++T+ V    P  ++ ++Q  T   G+     C
Sbjct: 3201 RIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARF-C 3259

Query: 167  TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA 226
              ++ +P   I W+K    L    + +   D    T  L+++   ED  V   C+ ++  
Sbjct: 3260 AVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL-LLIEAFPEDAAV-YTCEAKNDY 3317

Query: 227  VTGNLQTQRYLEV-------QYKPQVHIQMTYPLQG-LTREGDALELTCEAIGKPQPVMV 278
                      +EV       Q  P     +  PLQ  +T EG      C   G    + V
Sbjct: 3318 GVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTD--LKV 3375

Query: 279  TWVRVDDEMPQHAVLSGPN------LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYD 332
            +W   D ++                L I      D GTY   ASN VG+  S   L +  
Sbjct: 3376 SWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEA 3435

Query: 333  PPTTI 337
            P + +
Sbjct: 3436 PESIL 3440



 Score = 35.8 bits (81), Expect = 0.080
 Identities = 26/68 (38%), Positives = 34/68 (50%), Gaps = 6/68 (8%)

Query: 131   PQESYTTITV---LVPPRNLMIDIQKDTAV--EGEEIEVNCTAMASKPATTIRWFKGNTE 185
             P ES   IT    + PPR  M    KDT V   GE  +V+   +  KP  TI+W KG+ E
Sbjct: 22525 PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDAD-IYGKPIPTIQWIKGDQE 22583

Query: 186   LKGKSEVE 193
             L   + +E
Sbjct: 22584 LSNTARLE 22591



 Score = 35.8 bits (81), Expect = 0.080
 Identities = 29/116 (25%), Positives = 50/116 (43%), Gaps = 18/116 (15%)

Query: 225   PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
             P +  +L  Q  L++ +        TY +Q     G+ L++    IG+P+P  ++WV+  
Sbjct: 24302 PVIAKDLTIQPSLKLPFN-------TYSIQA----GEDLKIEIPVIGRPRP-NISWVKDG 24349

Query: 285   DEMPQ------HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             + + Q          +   L I   NK D G Y   A+N  G A  +  + V + P
Sbjct: 24350 EPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 25/108 (23%), Positives = 50/108 (46%), Gaps = 13/108 (12%)

Query: 25    RLRLLLLLFSAAALIPTGDGQNLFT---KDVTVIEGEVATISCQVNKSDDSVIQLLNPNR 81
             ++R+  +  S+ A +   +G   FT   +D T +E +   + C+++K+D  V        
Sbjct: 11997 QIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVK------- 12049

Query: 82    QTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTD 129
                +F+D + +K S+  ++     +  + L     SD G+Y C   TD
Sbjct: 12050 ---WFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTD 12094



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 22/85 (25%), Positives = 35/85 (41%), Gaps = 5/85 (5%)

Query: 260   GDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS----GPNLFINNLNKTDNGTYRCEA 315
             G  + +     GKP P  VTW   +  +PQ A +       ++ I N  ++  G Y   A
Sbjct: 16539 GGVIRIIAYVSGKPPPT-VTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLA 16597

Query: 316   SNIVGKAHSDYMLYVYDPPTTIPPP 340
              N  G+     ++ V D P  +  P
Sbjct: 16598 KNEAGERKKTIIVDVLDVPGPVGTP 16622



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 22/84 (26%), Positives = 39/84 (46%), Gaps = 6/84 (7%)

Query: 253   LQGLTREGDALELTCEAIGKPQPVMVTW---VRVDDEMPQHAVLSGPN---LFINNLNKT 306
             +  +  EG  ++  C+     Q   VTW   VR  +   ++ +        L++ ++ K 
Sbjct: 31575 MHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKL 31634

Query: 307   DNGTYRCEASNIVGKAHSDYMLYV 330
             D+GTYRC+  N  G+  S   L+V
Sbjct: 31635 DDGTYRCKVVNDYGEDSSYAELFV 31658



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 33/118 (27%), Positives = 45/118 (38%), Gaps = 11/118 (9%)

Query: 259  EGDALELTCEAIGKPQPVMVTWVRVDDEMP-----QHAVLSG-PNLFINNLNKTDNGTYR 312
            EG+++ L C   G P P  VTW R D ++      Q    SG   L I      D+G + 
Sbjct: 956  EGESVTLECHISGYPSPT-VTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFT 1014

Query: 313  CEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTIL----TIITDSRAGEE 366
            C A N  G   +   L V          T  T   TT     +     ++TD+   EE
Sbjct: 1015 CSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEE 1072



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 32/138 (23%), Positives = 57/138 (41%), Gaps = 15/138 (10%)

Query: 50    KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
             KDVT  E E A  +          ++L + N +  +F++ + L  +R   +        +
Sbjct: 11936 KDVTAKEKESAVFT----------VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSI 11985

Query: 110   SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
             +  ++SI D  +   +        S   +TVL         +Q  T VE +E+ + C   
Sbjct: 11986 TFKDLSIDDTSQIRVEAMG---MSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI- 12041

Query: 170   ASKPATTIRWFKGNTELK 187
              SK    ++WFK   E+K
Sbjct: 12042 -SKADAPVKWFKDGKEIK 12058



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 26/103 (25%), Positives = 42/103 (40%), Gaps = 8/103 (7%)

Query: 223   EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
             E   V G ++    LE    P   +   Y      R+G  + LT    GKP P+   W +
Sbjct: 30117 EPAEVPGTVKVTEMLEY---PDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPI-CKWTK 30172

Query: 283   VDDEMPQHAVL----SGPNLFINNLNKTDNGTYRCEASNIVGK 321
                ++ + A++    +   L I   ++ D+GTY     N  GK
Sbjct: 30173 EGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGK 30215



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 9/75 (12%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            K+VTVIEGE  T+ C ++      +        T Y  D++      FQ + F S   ++
Sbjct: 950  KNVTVIEGESVTLECHISGYPSPTV--------TWYREDYQIESSIDFQ-ITFQSGIARL 1000

Query: 110  SLTNVSISDEGRYFC 124
             +      D GR+ C
Sbjct: 1001 MIREAFAEDSGRFTC 1015



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 25/79 (31%), Positives = 30/79 (37%), Gaps = 5/79 (6%)

Query: 260   GDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS----GPNLFINNLNKTDNGTYRCEA 315
             GD L L+    G P P  VTW + D + P  A +     G  L I N    D G Y    
Sbjct: 17233 GDTLRLSAIIKGVPFP-KVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTV 17291

Query: 316   SNIVGKAHSDYMLYVYDPP 334
              N  G       + V D P
Sbjct: 17292 ENPAGSKTVSVKVLVLDKP 17310



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 44/213 (20%), Positives = 76/213 (35%), Gaps = 12/213 (5%)

Query: 130   PPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGK 189
             PP +  T    + PP      I + T      IE+     A      I  +  + +L G 
Sbjct: 14989 PPSDPKTAHDPISPPGP---PIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGT 15045

Query: 190   SEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA---VTGNLQTQRYLEVQYKPQVH 246
             +E    ++      Q  +K  +E     +     + A     G  Q     E Q  P V 
Sbjct: 15046 NEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVE 15105

Query: 247   IQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVL-----SGPNLFIN 301
             + ++         G  L +     G+P P  V W + + E+ +  V+     +   L I 
Sbjct: 15106 LDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKV-WTKEEGELDKDRVVIDNVGTKSELIIK 15164

Query: 302   NLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             +  + D+G Y   A+N  G   +   + V+D P
Sbjct: 15165 DALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 14/123 (11%)

Query: 83    TIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYT-------DPPQESY 135
             T Y  + R L + R+   NFS+  L+   T   ++++  Y  ++          PP E  
Sbjct: 21389 TSYIVEKRDLPNGRWLKANFSNI-LENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPS 21447

Query: 136   TTITVL--VPPRNLMIDIQ-KDTAV--EGEEIEVNCTAMASKPATTIRWFKGNTELKGKS 190
               IT    V    + +D++ KDT +   GE   +    ++ +P  T+ W K   EL+G +
Sbjct: 21448 DAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEAD-VSGRPPPTMEWSKDGKELEGTA 21506

Query: 191   EVE 193
             ++E
Sbjct: 21507 KLE 21509



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 33/163 (20%), Positives = 59/163 (36%), Gaps = 10/163 (6%)

Query: 174   ATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQT 233
             AT ++W     EL    E          T  +    H+++  +  I + +   V      
Sbjct: 33065 ATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDL 33124

Query: 234   QRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW------VRVDDEM 287
                 E+   P     ++ P      EG  +  TCE  G+P P  + W      + +   +
Sbjct: 33125 TLSKELSDAPAF---ISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISSNV 33180

Query: 288   PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
                   +  +L I N + +D+G Y  +A N  G+  +   L V
Sbjct: 33181 SISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV 33223



 Score = 32.7 bits (73), Expect = 0.68
 Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 29/189 (15%)

Query: 171   SKPATTIRWFK----GNTELKG------KSEVEEWSDM-----YTVTSQLMLKVHKEDDG 215
             +K + T+ W K    G +E+ G      K++ EEW  +       VT   + K+ +  + 
Sbjct: 23932 TKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEY 23991

Query: 216   VPVICQV------EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEA 269
                +C +      E  +V G ++ +  LE    P++ +        + R G +  +    
Sbjct: 23992 KIRVCALNKVGLGEATSVPGTVKPEDKLEA---PELDLDSELRKGIVVRAGGSARIHIPF 24048

Query: 270   IGKPQPVMVTWVRVDDEMPQHAVLS-GPN---LFINNLNKTDNGTYRCEASNIVGKAHSD 325
              G+P P  +TW R + E      +  G N   L I+N ++ D G Y  +  N  G   + 
Sbjct: 24049 KGRPTPE-ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAF 24107

Query: 326   YMLYVYDPP 334
               + V D P
Sbjct: 24108 VTVKVLDTP 24116



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 11/104 (10%)

Query: 253 LQGLT-REGDALELTCEAIGKPQPVMVTW-------VRVDDEMPQHAVLSGPNLFINNLN 304
           LQ +T R+G  + L     G P PV+  +         +D ++ Q   L   +L I    
Sbjct: 110 LQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLY--SLLIAEAY 167

Query: 305 KTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTT 348
             D+GTY   A+N VG+A S   L V      +P   T T  +T
Sbjct: 168 PEDSGTYSVNATNSVGRATSTAELLV-QGEEEVPAKKTKTIVST 210



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 38/168 (22%), Positives = 71/168 (42%), Gaps = 21/168 (12%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            KDV VIEG  A + C+V+  D + ++         Y  D +   D R Q +    ++ ++
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKW--------YLNDEQIKPDDRVQAI-VKGTKQRL 2502

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
             +     SDEG Y  +L     +   T   + V    ++  ++  T  E + +       
Sbjct: 2503 VINRTHASDEGPY--KLIVGRVE---TNCNLSVEKIKIIRGLRDLTCTETQNVVFE--VE 2555

Query: 170  ASKPATTIRWFKGNTELK--GKSEVEEWSDMYTVTSQLMLKVHKEDDG 215
             S     + W   + E+K   K ++E    +Y +T   +L + K+D+G
Sbjct: 2556 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLT---VLNMMKDDEG 2600



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 17/70 (24%), Positives = 40/70 (57%), Gaps = 8/70 (11%)

Query: 58    EVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS-RFQLLNFSSSELKVSLTNVSI 116
             E+A ++C V   + SV++     ++  +++D + LK++  FQ    +    ++ + N++ 
Sbjct: 32731 EIAKLTCVV---ESSVLRA----KEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTE 32783

Query: 117   SDEGRYFCQL 126
             SD+G Y C++
Sbjct: 32784 SDQGEYVCEI 32793



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 30/161 (18%), Positives = 75/161 (46%), Gaps = 15/161 (9%)

Query: 50    KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELK- 108
             ++VTV++G+   +SC++NK            R  ++ +D + + +   +++      ++ 
Sbjct: 11220 EEVTVVKGQPLYLSCELNK-----------ERDVVWRKDGKIVVEKPGRIVPGVIGLMRA 11268

Query: 109   VSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTA 168
             +++ +   +D G Y   +      E  + + V+   R+ ++   +D  V+ +   +    
Sbjct: 11269 LTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACD 11328

Query: 169   MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKV 209
             +A K    I+WFKG  E+   +E  + +++    + L LK+
Sbjct: 11329 IA-KDTPNIKWFKGYDEI--PAEPNDKTEILRDGNHLYLKI 11366



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 55/243 (22%), Positives = 85/243 (34%), Gaps = 30/243 (12%)

Query: 130   PPQESYTTITVL---VPPRNLMIDIQKD--TAVEGEEIEVNCTAMASKPATTIRWFKGNT 184
             PP E    +T+L   VPPR  +    K   T   G  + ++ T    KP  T+ W K  T
Sbjct: 19276 PPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFG-KPMPTVSWKKDGT 19334

Query: 185   ELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKP- 243
              LK    ++        T +L   V+++D G   I        +G+      L+V  KP 
Sbjct: 19335 LLKPAEGIKMAMQRNLCTLELF-SVNRKDSGDYTITAENS---SGSKSATIKLKVLDKPG 19390

Query: 244   ---QVHIQMTYPLQGLTR-----EGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSG 295
                 V I   Y  + +       E    E+T   + K +     W +V   +P       
Sbjct: 19391 PPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI------ 19444

Query: 296   PNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV-----YDPPTTIPPPTTTTTTTTTT 350
              +  +  L +     +R  A N  G     +         YDPP    PP  +  T    
Sbjct: 19445 TSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHM 19504

Query: 351   TTT 353
             T +
Sbjct: 19505 TVS 19507



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 48/204 (23%), Positives = 78/204 (38%), Gaps = 30/204 (14%)

Query: 50    KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
             KDVT   GE A +SCQ+       I+     ++ I  R ++   D R   L   + E + 
Sbjct: 30540 KDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE- 30598

Query: 110   SLTNVSISDEGRYFCQLYTDPPQESYTTITVLV-------PPRNLMIDIQKDTAVEGEEI 162
                     DEG Y C + T+   E  T+  +L+       P   L    +K     G  +
Sbjct: 30599 --------DEGVYTC-IATNEVGEVETSSKLLLQATPQFHPGYPLK---EKYYGAVGSTL 30646

Query: 163   EVNCTAMASKPATTIRWFKGNTELKGKSEVE-EWSDMYT--VTSQLMLKVHKEDDGVPVI 219
              ++      +P   + WF G   L+    +  E ++ YT  V   +  K H         
Sbjct: 30647 RLH-VMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGK------ 30699

Query: 220   CQVEHPAVTGNLQTQRYLEVQYKP 243
              +V+   V G +     +E+Q KP
Sbjct: 30700 YKVQLSNVFGTVDAILDVEIQDKP 30723



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 28/123 (22%), Positives = 46/123 (37%), Gaps = 9/123 (7%)

Query: 238   EVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAV----- 292
             ++ + P+V + +T       R G  + +     G+P+P  +TW +    + +        
Sbjct: 17901 DILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPD-ITWTKEGKVLVREKRVDLIQ 17959

Query: 293   -LSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTT 351
              L    L I    + D+G Y   A N  G A    ++ V D P   P      T  T   
Sbjct: 17960 DLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPG--PCQNLKVTNVTKEN 18017

Query: 352   TTI 354
              TI
Sbjct: 18018 CTI 18020



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 7/88 (7%)

Query: 271   GKPQPVMVTWVRVDDEMPQHAVLSGPN----LFINNLNKTDNGTYRCEASNIVGKAHSDY 326
             G+P P  V W R   E    A +   +    L + N+N+ D+G Y     N  G   +  
Sbjct: 21886 GRPAPE-VKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944

Query: 327   MLYVYDPPTTIPPPTTTTTTTTTTTTTI 354
              + V D P   PP        T T+ T+
Sbjct: 21945 NVRVLDTPG--PPQDLKVKEVTKTSVTL 21970



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 70/326 (21%), Positives = 124/326 (38%), Gaps = 56/326 (17%)

Query: 50   KDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV 109
            KD+ V+E + A   C+V++ D +V  + +     I  R    +K  + + ++      ++
Sbjct: 3065 KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDR----IKIQKEKYVH------RL 3114

Query: 110  SLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMI-DIQKDTAVEGE-----EIE 163
             + +  +SD G+     YT     + +T  + V  R++ I  I+K+  V  +     E E
Sbjct: 3115 LIPSTRMSDAGK-----YTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFE 3169

Query: 164  VNCTAMASKPATTIRWFKGNTELKGK-SEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
            VN      +      W+K   E+  +  E  ++     +    + +  + D G       
Sbjct: 3170 VN------EDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAG------- 3216

Query: 223  EHPAVTGNLQTQ--RYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAI-GKPQPVMVT 279
            E+  V G  ++    Y+     PQV       LQ +T +       C  I G+PQP  ++
Sbjct: 3217 EYTFVAGRNRSSVTLYVNAPEPPQV----LQELQPVTVQSGKPARFCAVISGRPQP-KIS 3271

Query: 280  WVRVDDEMPQ----HAVLSGP--NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDP 333
            W + +  +        +  G    L +      D   Y CEA N  G A +   L V  P
Sbjct: 3272 WYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVP 3331

Query: 334  PTTIP-------PPTTTTTTTTTTTT 352
                P       PP   T    T T+
Sbjct: 3332 EVVSPDQEMPVYPPAIITPLQDTVTS 3357



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 27/111 (24%), Positives = 43/111 (38%), Gaps = 16/111 (14%)

Query: 258   REGDALELTCEAIGKPQPVMVTWVRVDD--EMPQHAVL----------SGPNLFINNLNK 305
             + G+ + +  +  G P P  + W + +   E P  A+           +   L I    +
Sbjct: 15411 KAGEPVHIPADVTGLPMP-KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVR 15469

Query: 306   TDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
              D GTY   ASN +G    +  + VYD P+   PP     T     +  LT
Sbjct: 15470 EDKGTYTVTASNRLGSVFRNVHVEVYDRPS---PPRNLAVTDIKAESCYLT 15517



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 22/98 (22%), Positives = 44/98 (44%), Gaps = 7/98 (7%)

Query: 243   PQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA---VLSGPN-- 297
             P+V + + +    + + G+ L++  +  G+P PV ++W +   E+ + A   ++S  N  
Sbjct: 25787 PRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPV-ISWAKDGIEIEERARTEIISTDNHT 25845

Query: 298   -LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
              L + +  + D G Y     N+ G         V D P
Sbjct: 25846 LLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP 25883



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 19/86 (22%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 83    TIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVL- 141
             T + +D   +++S          + K+ + +V +SD G Y C L     +++ T   V+ 
Sbjct: 11149 TTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208

Query: 142   -VPPRNLMIDIQKDTAVEGEEIEVNC 166
              +P R +    ++ T V+G+ + ++C
Sbjct: 11209 ELPVRFVKTLEEEVTVVKGQPLYLSC 11234



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/112 (23%), Positives = 41/112 (36%), Gaps = 8/112 (7%)

Query: 243   PQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAV-------LSG 295
             P   +   Y    +   G+   L  +  GKP P +V W +   E+ + A        +  
Sbjct: 24705 PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVV-WSKDGKELEETAARMEIKSTIQK 24763

Query: 296   PNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTT 347
               L + +  +TD G Y  + SN+ G       + V D P     P   T  T
Sbjct: 24764 TTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVT 24815



 Score = 29.6 bits (65), Expect = 5.7
 Identities = 27/107 (25%), Positives = 42/107 (39%), Gaps = 10/107 (9%)

Query: 256   LTREGDALELTCEAIGKPQPVMVTW----VRVDDEMPQHAVLSGPNLFIN--NLNKTDNG 309
             + R G  + L     G+P P  +TW    V + D +      +  + F+   N+NK D G
Sbjct: 19704 ILRAGVTMRLYVPVKGRPPP-KITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAG 19762

Query: 310   TYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILT 356
              Y     N  GK     ++ V D P    PP   T    +  +  +T
Sbjct: 19763 KYILTLENSCGKKEYTIVVKVLDTP---GPPVNVTVKEISKDSAYVT 19806



 Score = 29.6 bits (65), Expect = 5.7
 Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 11/83 (13%)

Query: 260   GDALELTCEAIGKPQPVMVTWVRVDDEMPQHAV--------LSGPNLFINNLNKTDNGTY 311
             G  L++     G+P+P  +TW +  D +P            L    L I   +K D G Y
Sbjct: 23244 GQDLKIEVPISGRPKPT-ITWTK--DGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQY 23300

Query: 312   RCEASNIVGKAHSDYMLYVYDPP 334
                 +N+VG+  +   +   D P
Sbjct: 23301 GITVANVVGQKTASIEIVTLDKP 23323



 Score = 29.6 bits (65), Expect = 5.7
 Identities = 53/277 (19%), Positives = 93/277 (33%), Gaps = 47/277 (16%)

Query: 84    IYFRDFRPLKDSRFQ---LLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITV 140
             +Y +D   L D  ++   + ++        L    + +   Y+C+      +    T+ +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685

Query: 141   LVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELK-GKSEVEEWSDMY 199
             L  P    + +   TA  GE +    T +   P   + W+K   ++K G ++ +   +  
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVT-ITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 31744

Query: 200   TVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLT-- 257
                 QL +     DD        E+  V  N    +Y E   K ++ + +  P    T  
Sbjct: 31745 KGLYQLTINSVTTDD------DAEYTVVARN----KYGEDSCKAKLTVTLHPPPTDSTLR 31794

Query: 258   ------------REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN-------- 297
                         +EG ++       G P P +  W     E     +  GPN        
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTL-KW-----EKDGQPLSLGPNIEIIHEGL 31848

Query: 298   ----LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
                 L I +    D G YR  A+N  G       L V
Sbjct: 31849 DYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885



 Score = 29.3 bits (64), Expect = 7.5
 Identities = 28/115 (24%), Positives = 42/115 (36%), Gaps = 9/115 (7%)

Query: 258   REGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS------GPNLFINNLNKTDNGTY 311
             R G  L L     GKP+P ++ W + D E+     +S           I   +++D+G Y
Sbjct: 29060 RAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKY 29118

Query: 312   RCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEE 366
                  N  G      M+ V D P   P    T +  T    T+   +     G E
Sbjct: 29119 TLTVKNASGTKAVSVMVKVLDSPG--PCGKLTVSRVTQEKCTLAWSLPQEDGGAE 29171



 Score = 28.9 bits (63), Expect = 9.8
 Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 8/82 (9%)

Query: 111   LTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMA 170
             LT +S + EG   CQ      +E       +  PR+  I+       EG+ +   C  ++
Sbjct: 33107 LTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNIN-------EGQNVLFTCE-IS 33158

Query: 171   SKPATTIRWFKGNTELKGKSEV 192
              +P+  I WFK N  +   S V
Sbjct: 33159 GEPSPEIEWFKNNLPISISSNV 33180


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 67/255 (26%), Positives = 100/255 (39%), Gaps = 21/255 (8%)

Query: 105  SELKVSLTNVSISDEGRYFC----QLYTDPPQESYTTITVLVPPRNLMIDIQKD--TAVE 158
            S   + +++   SD G Y C     L T   Q      T  + P    +  ++   T   
Sbjct: 3166 SHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA 3225

Query: 159  GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
            G    + C+A  S PA TI W K  + L        W       + ++ +V ++D G   
Sbjct: 3226 GHTATLRCSATGS-PAPTIHWSKLRSPLP-------WQHRLEGDTLIIPRVAQQDSG-QY 3276

Query: 219  ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMV 278
            IC    PA  G+ +    L V+  P      T P     + G+ ++L C A G P P+  
Sbjct: 3277 ICNATSPA--GHAEATIILHVESPPYA---TTVPEHASVQAGETVQLQCLAHGTP-PLTF 3330

Query: 279  TWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
             W RV   +P  A      L        D+G YRC  +N VG A +   L V  PP ++P
Sbjct: 3331 QWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLP 3390

Query: 339  PPTTTTTTTTTTTTT 353
              +    +T T   T
Sbjct: 3391 ATSIPAGSTPTVQVT 3405



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 67/238 (28%), Positives = 99/238 (41%), Gaps = 31/238 (13%)

Query: 118  DEGRYFCQLYTDPPQ-ESYTTITVLVPPRNL-------------MIDIQKDTAVEGEEIE 163
            D GRY C++       E++  + V  PP +L              +  Q +T   G  +E
Sbjct: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVE 3418

Query: 164  VNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVP--VICQ 221
             +C A+ S   T +RWFK   +L     V++           +L++   D       ICQ
Sbjct: 3419 FHC-AVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQSCQGTYICQ 3467

Query: 222  VEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWV 281
               P   G  Q    L +Q  P V I +   +Q +   G A+E  C A+G P+P  VTW 
Sbjct: 3468 AHGP--WGKAQASAQLVIQALPSVLINIRTSVQTVV-VGHAVEFECLALGDPKP-QVTWS 3523

Query: 282  RVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
            +V   +    V SG  + I ++   D G YRC A+N  G   S  +L V   P    P
Sbjct: 3524 KVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMP 3581



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 55/232 (23%), Positives = 93/232 (40%), Gaps = 39/232 (16%)

Query: 108  KVSLTNVSISDEGRYFCQLYTDP-PQESYTTITVL-----------VP--PRNLMIDIQK 153
            ++ L  VS +D G Y C++     P+E+  T++VL           VP   R + I+   
Sbjct: 2101 RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS 2160

Query: 154  DTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKED 213
                EG+ +++NC       A  + W K    L  + +          T   +L++H+  
Sbjct: 2161 SHVAEGQTLDLNCVVPGQAHAQ-VTWHKRGGSLPARHQ----------THGSLLRLHQVT 2209

Query: 214  --DGVPVICQVEHPAVTGNLQTQRYLEVQYK------PQVHIQMTYPLQGLTREGDALEL 265
              D    +C V     +G L+    + ++        P V I+ +        EG  L+L
Sbjct: 2210 PADSGEYVCHVV--GTSGPLEASVLVTIEASVIPGPIPPVRIESS---SSTVAEGQTLDL 2264

Query: 266  TCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASN 317
            +C   G+     VTW +    +P    + G  L+I   +  D G Y C ASN
Sbjct: 2265 SCVVAGQAH-AQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN 2315



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 56/243 (23%), Positives = 94/243 (38%), Gaps = 21/243 (8%)

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYTTITVLVP---PRNLMIDIQKDTAVEGEEIEVNCT 167
            L  V  +D+ +Y C+ ++   Q+    +  +     PR + +  ++     G  + + C 
Sbjct: 1920 LPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPR-VQVSPERTQVHAGRTVRLYCR 1978

Query: 168  AMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAV 227
            A A  P+ TI W K    L  ++  E      T  + L++      D    +C    PA 
Sbjct: 1979 A-AGVPSATITWRKEGGSLPPQARSER-----TDIATLLIPAITTADAGFYLCVATSPAG 2032

Query: 228  TGNLQTQRYL---EVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
            T   + Q  +        P V I+ + P      EG  L+L C   G      VTW R  
Sbjct: 2033 TAQARIQVVVLSASDASPPPVKIESSSPS---VTEGQTLDLNCVVAGSAH-AQVTWYRRG 2088

Query: 285  DEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV----YDPPTTIPPP 340
              +P H  + G  L +  ++  D+G Y C   N  G   +   + V    +  P+  P P
Sbjct: 2089 GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVP 2148

Query: 341  TTT 343
             +T
Sbjct: 2149 GST 2151



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 70/307 (22%), Positives = 116/307 (37%), Gaps = 44/307 (14%)

Query: 53   TVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLT 112
            TV+EG+   ++C V +   ++I        T Y R       SR Q      S L+  L 
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAII--------TWYKRGGS--LPSRHQT---HGSHLR--LH 2684

Query: 113  NVSISDEGRYFCQLYTD-PPQESYTTITVL-------VPPRNLMIDIQKDTA--VEGEEI 162
             +S++D G Y C+   +    E+   I+V         P  ++ I I+  ++   EGE +
Sbjct: 2685 QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETL 2744

Query: 163  EVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
            ++NC       A  + W K    L    +        T  S+L L      D    +C+V
Sbjct: 2745 DLNCVVPGQAHAQ-VTWHKRGGSLPSHHQ--------TRGSRLRLHHVSPADSGEYVCRV 2795

Query: 223  EHPAVTGNLQTQRYLEVQYKPQVHIQMT--------YPLQGLTREGDALELTCEAIGKPQ 274
               +          +E      VH+            P      EG  L+L C   G+  
Sbjct: 2796 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH 2855

Query: 275  PVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY-DP 333
               VTW +    +P    + GP L +N ++  D+G Y C+ +   G   +  ++ +    
Sbjct: 2856 -AQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSS 2914

Query: 334  PTTIPPP 340
            P  IP P
Sbjct: 2915 PGPIPAP 2921



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 62/237 (26%), Positives = 94/237 (39%), Gaps = 24/237 (10%)

Query: 111  LTNVSISDEGRYFCQLYTD--PPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTA 168
            + N+  S +G Y CQ +      Q S   +   +P   + I     T V G  +E  C A
Sbjct: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA 3512

Query: 169  MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKV-HKE-DDGVPVICQVEHPA 226
            +   P   + W K    L+             V S  ++++ H E  D     C   + A
Sbjct: 3513 LGD-PKPQVTWSKVGGHLRPG----------IVQSGGVVRIAHVELADAGQYRCTATNAA 3561

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDE 286
              G  Q+   L VQ  PQ+ +    P +     G A    C A G P P  ++W ++D  
Sbjct: 3562 --GTTQSHVLLLVQALPQISM----PQEVRVPAGSAAVFPCIASGYPTPD-ISWSKLDGS 3614

Query: 287  MPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTT 343
            +P  + L    L + ++   D GTY C A+N  GK  +   L V  P   +P  T T
Sbjct: 3615 LPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV--PERVVPYFTQT 3669



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 57/256 (22%), Positives = 100/256 (39%), Gaps = 36/256 (14%)

Query: 114  VSISDEGRYFCQLYTDPPQESYTTITVLV------PPRNLMIDIQKDTAVEGEEIEVNCT 167
            ++ +D G Y C + T P   +   I V+V       P  + I+    +  EG+ +++NC 
Sbjct: 2015 ITTADAGFYLC-VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCV 2073

Query: 168  AMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAV 227
               S  A  + W++    L   ++V          S+L L      D    +C+VE+   
Sbjct: 2074 VAGSAHAQ-VTWYRRGGSLPPHTQVHG--------SRLRLPQVSPADSGEYVCRVEN--- 2121

Query: 228  TGNLQTQRYLEVQYKPQVHIQMTY-PLQGLTR------------EGDALELTCEAIGKPQ 274
             G+   +  + V      H   +Y P+ G TR            EG  L+L C   G+  
Sbjct: 2122 -GSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAH 2180

Query: 275  PVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDP- 333
               VTW +    +P      G  L ++ +   D+G Y C      G   +  ++ +    
Sbjct: 2181 -AQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASV 2239

Query: 334  -PTTIPPPTTTTTTTT 348
             P  IPP    ++++T
Sbjct: 2240 IPGPIPPVRIESSSST 2255



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 55/246 (22%), Positives = 92/246 (37%), Gaps = 33/246 (13%)

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRN------------LMIDIQKDTAVE 158
            L  VS +D G Y CQ+ T        ++ V + P +            + I+       E
Sbjct: 2880 LNQVSPADSGEYSCQV-TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938

Query: 159  GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
            G+ +++NC       A  + W+K    L  + +        T  SQL L +    D    
Sbjct: 2939 GQTLDLNCVVPGQAHAQ-VTWYKRGGSLPARHQ--------THGSQLRLHLVSPADSGEY 2989

Query: 219  ICQVEHPAVTGNLQTQRYLEV-------QYKPQVHIQMTYPLQGLTREGDALELTCEAIG 271
            +C+    +  G  Q   +           Y+ +  +    P     ++G      C    
Sbjct: 2990 VCRAA--SGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHD 3047

Query: 272  KPQPVMVTWVRVDDEMPQHAVLS--GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
               P+ + W   + E+  +  +S  G  + I     +++GTYRC ASN  G A S   L 
Sbjct: 3048 GAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLS 3107

Query: 330  VYDPPT 335
            V+ PPT
Sbjct: 3108 VHGPPT 3113



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 50/259 (19%), Positives = 97/259 (37%), Gaps = 24/259 (9%)

Query: 111  LTNVSISDEGRYFCQ-LYTDPPQESYTTITV--------LVPPRNLMIDIQKDTAVEGEE 161
            L   S +D G Y C+ L +  P E+   +T+        L     + I+       EG+ 
Sbjct: 2394 LYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQT 2453

Query: 162  IEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQ 221
            +++NC  +A +    + W K    L  + +V          S+L L      D    +C+
Sbjct: 2454 LDLNCL-VAGQAHAQVTWHKRGGSLPARHQVHG--------SRLRLLQVTPADSGEYVCR 2504

Query: 222  VEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQ-----GLTREGDALELTCEAIGKPQPV 276
            V   + T        ++ +        + YP++          G  L+L C  +    P 
Sbjct: 2505 VVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC-LVASQAPH 2563

Query: 277  MVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTT 336
             +TW +    +P    + G  L I  +   D+G Y C  SN  G   +  ++ +    ++
Sbjct: 2564 TITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623

Query: 337  IPPPTTTTTTTTTTTTTIL 355
              P  +      +++ T++
Sbjct: 2624 HVPSVSPPIRIESSSPTVV 2642



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 48/239 (20%), Positives = 94/239 (39%), Gaps = 28/239 (11%)

Query: 108  KVSLTNVSISDEGRYFCQLYTDP-PQESYTTITV----------LVPPRNLMIDIQKDTA 156
            ++ +  V+ +D G Y C +      +E+   +T+          + PP  + I+    T 
Sbjct: 2584 RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP--IRIESSSPTV 2641

Query: 157  VEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGV 216
            VEG+ +++NC  +A +P   I W+K    L  + +        T  S L L      D  
Sbjct: 2642 VEGQTLDLNC-VVARQPQAIITWYKRGGSLPSRHQ--------THGSHLRLHQMSVADSG 2692

Query: 217  PVICQVEH--PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLT---REGDALELTCEAIG 271
              +C+  +   A+  ++                 M   ++  +    EG+ L+L C   G
Sbjct: 2693 EYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2752

Query: 272  KPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
            +     VTW +    +P H    G  L +++++  D+G Y C      G   +  ++ +
Sbjct: 2753 QAH-AQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTI 2810



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 60/252 (23%), Positives = 108/252 (42%), Gaps = 33/252 (13%)

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVE-GEEIEVNCTAM 169
            +  V+  D G+Y C   T P   +  TI + V        + +  +V+ GE +++ C A 
Sbjct: 3265 IPRVAQQDSGQYICNA-TSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAH 3323

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLML--KVHKEDDGVPVICQVEHPAV 227
             + P T  +W +  + L G++         T  ++L+   +   ED G    C+V +   
Sbjct: 3324 GTPPLT-FQWSRVGSSLPGRA---------TARNELLHFERAAPEDSG-RYRCRVTNKV- 3371

Query: 228  TGNLQTQRYLEVQYKP------------QVHIQMTYPLQGLTREGDALELTCEAIGKPQP 275
             G+ +    L VQ  P               +Q+T  L+  +  G ++E  C A+   + 
Sbjct: 3372 -GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSI-GASVEFHC-AVPSDRG 3428

Query: 276  VMVTWVRVDDEMPQ-HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
              + W +   ++P  H+V  G  L I NL+++  GTY C+A    GKA +   L +   P
Sbjct: 3429 TQLRWFKEGGQLPPGHSVQDGV-LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALP 3487

Query: 335  TTIPPPTTTTTT 346
            + +    T+  T
Sbjct: 3488 SVLINIRTSVQT 3499



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 54/260 (20%), Positives = 99/260 (38%), Gaps = 35/260 (13%)

Query: 111  LTNVSISDEGRYFCQLY-TDPPQESYTTITVL-------VPPRNLMIDIQKDTAVEGEEI 162
            L  V+ +D G Y C +  T  P E+   +T+        +PP  + I+    T  EG+ +
Sbjct: 2205 LHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP--VRIESSSSTVAEGQTL 2262

Query: 163  EVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
            +++C  +A +    + W+K    L  + +V          S+L +      D    +C+ 
Sbjct: 2263 DLSCV-VAGQAHAQVTWYKRGGSLPARHQVRG--------SRLYIFQASPADAGQYVCRA 2313

Query: 223  EHP-------AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQP 275
             +         VTG               + I+   P      EG  L+L C   G+   
Sbjct: 2314 SNGMEASITVTVTGTQGANLAYPAGSTQPIRIE---PSSSQVAEGQTLDLNCVVPGQSH- 2369

Query: 276  VMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCE--ASNIVGKAHSDYMLYVYDP 333
              VTW +    +P      G  L +   +  D+G Y C    S++  +A    +L   +P
Sbjct: 2370 AQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEAS---VLVTIEP 2426

Query: 334  PTTIPPPTTTTTTTTTTTTT 353
              ++P    T T    ++++
Sbjct: 2427 AGSVPALGVTPTVRIESSSS 2446



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 56/260 (21%), Positives = 93/260 (35%), Gaps = 38/260 (14%)

Query: 109  VSLTNVSISDEGRYFCQ-------------LYTDPPQESYTTITVLVPPRNLMIDIQKDT 155
            +++ NV +SD G Y C              L+          +  + PP+         T
Sbjct: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQL--------T 1876

Query: 156  AVEGEEIEVNCTAMASKPATTIRWFKG-NTELKGKSEVEEWSDMYTVTSQLMLKVHKEDD 214
               G+  E  C+A  S P  T+ W  G   +L  K+++            L L   +  D
Sbjct: 1877 VQPGQLAEFRCSATGS-PTPTLEWTGGPGGQLPAKAQIHG--------GILRLPAVEPTD 1927

Query: 215  GVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQ 274
                +C+    A  G    +  L V       +Q++ P +     G  + L C A G P 
Sbjct: 1928 QAQYLCRAHSSA--GQQVARAVLHVHGGGGPRVQVS-PERTQVHAGRTVRLYCRAAGVPS 1984

Query: 275  PVMVTWVRVDDEMPQHAVLSGPN---LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
               +TW +    +P  A     +   L I  +   D G Y C A++  G A +   + V 
Sbjct: 1985 AT-ITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVL 2043

Query: 332  DPPTTIPPPTTTTTTTTTTT 351
                  PPP    +++ + T
Sbjct: 2044 SASDASPPPVKIESSSPSVT 2063



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 50/239 (20%), Positives = 94/239 (39%), Gaps = 17/239 (7%)

Query: 113  NVSISDEGRYFCQLYTDPPQESYTTITVLVP-----PRNLMIDIQKDTAVE-GEEIEVNC 166
            +V  SD G Y C    +  Q + +   +LV      P  + ++ Q+  +V  G ++   C
Sbjct: 1735 SVQPSDAGVYICTC-RNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFIC 1793

Query: 167  TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPA 226
            TA +  PA T+ W + +   K  +   +++ + T+ +     V   D G   +C   +  
Sbjct: 1794 TAKSKSPAYTLVWTRLHNG-KLPTRAMDFNGILTIRN-----VQLSDAGT-YVCTGSNMF 1846

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDE 286
                     +++        +   +P Q   + G   E  C A G P P +        +
Sbjct: 1847 AMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQ 1906

Query: 287  MPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY---DPPTTIPPPTT 342
            +P  A + G  L +  +  TD   Y C A +  G+  +  +L+V+    P   + P  T
Sbjct: 1907 LPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERT 1965



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 11/85 (12%)

Query: 243 PQVHIQMTYPLQGL-TREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN---- 297
           PQV   +T P + +    G  +  TC AIG P P+ + W      +P H  ++  +    
Sbjct: 406 PQV---VTPPRESIQASRGQTVTFTCVAIGVPTPI-INWRLNWGHIPSHPRVTVTSEGGR 461

Query: 298 --LFINNLNKTDNGTYRCEASNIVG 320
             L I ++ ++D G Y CEA N  G
Sbjct: 462 GTLIIRDVKESDQGAYTCEAMNARG 486


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/286 (23%), Positives = 117/286 (40%), Gaps = 22/286 (7%)

Query: 79   PNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTI 138
            P+   ++ +D  P+  +    L        ++L +   SD GRY C   +   ++    +
Sbjct: 2005 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 2064

Query: 139  TVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDM 198
              +  P +++ +    + V  E + + C + A  P   + W+K    L+ +  V   +D 
Sbjct: 2065 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRPGVHLSAD- 2122

Query: 199  YTVTSQLMLKVHKED--DGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL 256
                 + +L+V + D  D     C+  + A  G+ +    L V   P   ++ ++ L   
Sbjct: 2123 -----KALLQVDRADVWDAGHYTCEALNQA--GHSEKHYNLNVWVAPVFPLRESHTLT-- 2173

Query: 257  TREGDALELTCEAIGKPQPVMVTWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGT 310
             REG    L+CE  G P P  ++W +    +P      QH    G  L++        GT
Sbjct: 2174 VREGHPTSLSCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPP--PTTTTTTTTTTTTTI 354
            Y CE SN+VG +  D  L V+ PP    P  P T  +       T+
Sbjct: 2233 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 2278



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 86/313 (27%), Positives = 122/313 (38%), Gaps = 32/313 (10%)

Query: 42   GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS-RFQLL 100
            GD + L  ++VTV      ++ C           L NP     + ++  P   S R Q+L
Sbjct: 2846 GDTEEL-VEEVTVNASSTVSLQCPA---------LGNPVPTISWLQNGLPFSPSPRLQVL 2895

Query: 101  NFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEG 159
                  L+VS   V+  D   Y C         E   T+ V VPPR   +D+++ TA+  
Sbjct: 2896 E-DGQVLQVSTAEVA--DAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 2952

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
              + + C   A  P   + W+K +  L    EV     +   T  L L   +  D     
Sbjct: 2953 SSVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVF----LLPGTHTLQLGRARLSDSGMYT 3007

Query: 220  CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQG-LTREGDALELTCEAIGKPQPVMV 278
            C+  + A  G  Q    L V   P        P    L R GD   L+CE    P+P  V
Sbjct: 3008 CEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 3064

Query: 279  TWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYD 332
            TW +  D  P        A+  G  L I     +D G Y C+ SN+ G+A   + L V  
Sbjct: 3065 TWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV 3122

Query: 333  PPTTIPPPTTTTT 345
            PPT   P T T +
Sbjct: 3123 PPTFENPKTETVS 3135



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 74/305 (24%), Positives = 121/305 (39%), Gaps = 21/305 (6%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            F  A L+      +   ++  V+EG+   + C+ +           P     + +D  PL
Sbjct: 3208 FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQ---------PPPDVAWLKDGSPL 3258

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDI 151
                   L F      + L  +  SD G Y C  +    +++   T+ VLVPP       
Sbjct: 3259 GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGAD 3318

Query: 152  QKDTAVE--GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKV 209
               T V   GE + + C    S P   + W K    L            +T+    + KV
Sbjct: 3319 GSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLR---ISKV 3374

Query: 210  HKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEA 269
               D G+   C    PA  G       L+VQ  P +   + +    +   G  +EL CEA
Sbjct: 3375 QLADAGI-FTCVAASPA--GVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEA 3430

Query: 270  IGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             G P P +V+W++  + +   ++  GP+L +  +   D+GTY C A +  G+A   + L 
Sbjct: 3431 RGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489

Query: 330  VYDPP 334
            V +PP
Sbjct: 3490 VMEPP 3494



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 78/314 (24%), Positives = 115/314 (36%), Gaps = 28/314 (8%)

Query: 51   DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
            +V+V+  E   + CQ +     V+          +++D RPL+      ++ S+ +  + 
Sbjct: 2079 NVSVVANESVALECQSHAMPPPVLS---------WWKDGRPLEPRPG--VHLSADKALLQ 2127

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    + D G Y C+        E +  + V V P   + +    T  EG    ++C   
Sbjct: 2128 VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECR 2187

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
               P   I W K    L G  E      +  V   L L   +        C+  +  V G
Sbjct: 2188 GV-PFPKISWRKDGQPLPG--EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN--VVG 2242

Query: 230  NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQ 289
            N      LEV   PQ+      P Q    +     L C A GKP P  VTW R  D  P 
Sbjct: 2243 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT-VTWER--DGQPV 2299

Query: 290  HAVLS------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP--PPT 341
             A L       G +L +        G Y C A N+ G+A   + L V  PP  I    P 
Sbjct: 2300 GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL 2359

Query: 342  TTTTTTTTTTTTIL 355
            T  T    +  T+L
Sbjct: 2360 TNITAALHSPLTLL 2373



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 58/231 (25%), Positives = 90/231 (38%), Gaps = 22/231 (9%)

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMA 170
            L  V + D G Y C         S+  +  +  P  +    +    + GE +++NC A  
Sbjct: 1086 LAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEG 1145

Query: 171  SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGN 230
            + P   + W K    L+G+               +     +  D     C+  + A    
Sbjct: 1146 N-PEPQLSWSKDGVVLQGRGP----------QGSVHFAAIRTSDAGRYRCEASNSAGVDA 1194

Query: 231  LQTQRYLEVQYKPQVHIQMTYPLQGLTR-EGDALELTCEAIGKPQPVMVTWVRVDDEMPQ 289
             + +  L V   P      T  L  L R  G+   L C A G P+P  VTW +     P 
Sbjct: 1195 WEVE--LRVLEPPHWGADETSGL--LERVAGENASLPCPARGTPKP-QVTWRKGPSSEPL 1249

Query: 290  H-----AVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            H     AVL   +LF+ +++  D+G Y C+A+N VG       L VY PP+
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPS 1300



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 59/239 (24%), Positives = 101/239 (42%), Gaps = 24/239 (10%)

Query: 109  VSLTNVSISDEGRYFCQLYTDPPQESYTTIT--VLVPPRNLMIDIQKDTAVEGEEIEVNC 166
            + +  V + DEG Y C   T+   ES   +   VLVPP N+         +E   + + C
Sbjct: 1850 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPP-NIEPGPVNKAVLENASVTLEC 1907

Query: 167  TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKED--DGVPVICQVEH 224
             A +  P   + WFKG+        V  W  +       +L++ +    D     C   +
Sbjct: 1908 LA-SGVPPPDVSWFKGH------QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN 1960

Query: 225  PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
              V G+ + +  L V   P++ +  + P  G       + LTC A G P P ++ W++  
Sbjct: 1961 --VAGSTELRYGLRVNVPPRITLPPSLP--GPVLVNTPVRLTCNATGAPSPTLM-WLKDG 2015

Query: 285  DEM-----PQHAVLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
            + +     P   V  G   L + +   +D+G Y C A + VG+   D +L V+ PP+ +
Sbjct: 2016 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 2074



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 70/317 (22%), Positives = 127/317 (40%), Gaps = 36/317 (11%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            FS   L+P         + + V++G+ A + C V           +P  +  +F+D RPL
Sbjct: 2436 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG---------HPQPKLTWFKDGRPL 2486

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQES-YTTITVLVPPRNLMIDI 151
              +R    + S   + + +   ++S  G Y C       +++ +  ++VL+ P   ++  
Sbjct: 2487 --ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT--ILGG 2542

Query: 152  QKDTAVEGEEIEVN------CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQL 205
             +D+A E   + VN      C A+A  P+  I W K     +    ++     + +    
Sbjct: 2543 AEDSADEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQ--- 2598

Query: 206  MLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGD 261
            +L   KED G    C V +    G      ++EV   P +         G+    T+   
Sbjct: 2599 ILNAQKEDAG-QYTCVVTNEL--GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655

Query: 262  ALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS----GPNLFINNLNKTDNGTYRCEASN 317
             L L CE+   P P  + W +    +   + L     G  L I     +D+G Y C A+N
Sbjct: 2656 TLTLECESWAVPPPT-IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 318  IVGKAHSDYMLYVYDPP 334
            + G+   D+ + +  PP
Sbjct: 2715 VAGEDDQDFNVLIQVPP 2731



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 68/300 (22%), Positives = 120/300 (40%), Gaps = 23/300 (7%)

Query: 45   QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSS 104
            +N  T+ V+ + G    ++C V+           P     + +D  P++ S        S
Sbjct: 3127 ENPKTETVSQVAGSPLVLTCDVSGV---------PAPTVTWLKDRMPVESSAVH--GVVS 3175

Query: 105  SELKVSLTNVSISDEGRYFCQLY-TDPPQESYTTITVLVPPRNLMIDIQKDTAV-EGEEI 162
               ++ L+ +  +  G Y C    T         + VLV PR     + ++  V EG+E+
Sbjct: 3176 RGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEV 3235

Query: 163  EVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
             ++C A   +P   + W K  + L    ++      Y     L+LK  +  D     C  
Sbjct: 3236 RLDCEA-DGQPPPDVAWLKDGSPLG--QDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 3292

Query: 223  EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
             +PA  G       + V   P +          ++R G+ + + C   G P P+ V+W++
Sbjct: 3293 HNPA--GEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSWLK 3349

Query: 283  VDDEMP--QHAVL--SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
                +P  Q  +L  SG  L I+ +   D G + C A++  G A  ++ L V  PP   P
Sbjct: 3350 DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEP 3409



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 77/300 (25%), Positives = 121/300 (40%), Gaps = 45/300 (15%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLK-DSRFQLLNFSSSELKVS 110
            V V  G+ A +SC+ +           P     +++D +PL    R Q L       ++ 
Sbjct: 3042 VLVRVGDKAVLSCETDAL---------PEPTVTWYKDGQPLVLAQRTQALRGGQ---RLE 3089

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    +SD+G Y C++     +   T T+TV VPP       +  + V G  + + C  +
Sbjct: 3090 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD-V 3148

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ---LMLKVHKEDDGVPVICQVEHPA 226
            +  PA T+ W      LK +  VE  S ++ V S+   L L   +        C  E+  
Sbjct: 3149 SGVPAPTVTW------LKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-- 3199

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALE-----LTCEAIGKPQPVMVTWV 281
                  TQ      +   V +       G+ RE   LE     L CEA G+P P  V W+
Sbjct: 3200 ------TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWL 3252

Query: 282  R----VDDEMPQHA--VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            +    +  +M  H    L G +L +  L  +D G Y C A N  G+    + + V  PPT
Sbjct: 3253 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPT 3312



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 76/312 (24%), Positives = 120/312 (38%), Gaps = 37/312 (11%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL-KDSRFQLLNFSSSELKVS 110
            V+V++  VAT+ C              P     + RD +P+  +   QL N   S   + 
Sbjct: 2268 VSVVQDGVATLECNATGK---------PPPTVTWERDGQPVGAELGLQLQNQGQS---LH 2315

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNL--MIDIQKDTAVEGEEIEVNCT 167
            +     +  GRY C       + E    ++VLVPP  +  +  +   TA     + + C 
Sbjct: 2316 VERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCE 2375

Query: 168  AMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHK--EDDGVPVICQVEHP 225
            AM   P   IRWF+G      +  V    D Y +    MLK+ +  E D     C   + 
Sbjct: 2376 AMGIPPPA-IRWFRG------EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 2428

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTR--EGDALELTCEAIGKPQPVMVTWVRV 283
            A  G  +    +EV   P +  +    L+ + +  +G    L C   G PQP + TW + 
Sbjct: 2429 A--GEARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKL-TWFKD 2482

Query: 284  DDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
               + +    H    G  L +   N +  G Y C A+N VG+    + L V   PT +  
Sbjct: 2483 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 2542

Query: 340  PTTTTTTTTTTT 351
               +     T T
Sbjct: 2543 AEDSADEEVTVT 2554



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 74/298 (24%), Positives = 120/298 (40%), Gaps = 30/298 (10%)

Query: 51  DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
           +VTV  GE A +SC+V         L        + RD+R L  S  ++   +   L++S
Sbjct: 525 NVTVSPGETAVLSCRV---------LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEIS 575

Query: 111 LTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPR-NLMIDIQKDTAVEGEEIEVNCTAM 169
              +  +D GRY C + ++    +  ++ +LV     + I        +G E++V+C+A 
Sbjct: 576 --GIIPTDGGRYQC-VASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA- 631

Query: 170 ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
           +  P   I W + +  L+  S +            L+++    +D     CQ  +   T 
Sbjct: 632 SGYPTPHISWSRESQALQEDSRIH-----VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 686

Query: 230 NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEM-- 287
               Q  + + Y     +     +  L   G+   L CEA G P P  V W R   EM  
Sbjct: 687 ----QETVTLYYTDPPSVSAVNAVV-LVAVGEEAVLVCEASGVPPP-RVIWYRGGLEMIL 740

Query: 288 -PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTT 344
            P+ +  S   L I    + D GTY C A N +G A ++  L V   P     P   T
Sbjct: 741 APEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVT 796



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 86/335 (25%), Positives = 130/335 (38%), Gaps = 41/335 (12%)

Query: 9    GSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNK 68
            G +      A +P G + R   L   A    PT  G N  T +V V+E  +  + C+   
Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAP---PTIWGSNE-TGEVAVMEDHLVQLLCEARG 1528

Query: 69   SDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYT 128
                      P     +F+D   L  S   +      +L+  L     SD G Y C+   
Sbjct: 1529 V---------PTPNITWFKDGALLPTSTKVVYTRGGRQLQ--LGRAQSSDAGVYTCKASN 1577

Query: 129  DP-PQESYTTITVLVPP-------RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180
                 E  T + V VPP       R  ++      AV G  + + C A    P+ T+ W 
Sbjct: 1578 AVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGH-PSPTLSWH 1631

Query: 181  KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240
                 +   +E    S + T  S L L+   E       C    PA  G    Q  +EVQ
Sbjct: 1632 HEGLPVAESNE----SRLETDGSVLRLESPGEASSGLYSCVASSPA--GEAVLQYSVEVQ 1685

Query: 241  YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHAVLS-GP 296
              PQ+ +      Q  T  G  LEL C+A G P P  + W+   R  +E+    V S G 
Sbjct: 1686 VPPQLLVAEGLG-QVTTIVGQPLELPCQASGSPVPT-IQWLQNGRPAEELAGVQVASQGT 1743

Query: 297  NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
             L I+++    +G + C+A+N  G A ++  + V+
Sbjct: 1744 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 1778



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 69/280 (24%), Positives = 115/280 (41%), Gaps = 32/280 (11%)

Query: 62  ISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKV-SLTNVSISDEG 120
           +SC V+ +    +QL     +    R F+   +S +++L  S +E      T VS +  G
Sbjct: 446 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTG 505

Query: 121 RYFCQLY-TDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRW 179
           R   Q+  TDPP +       LVP  N+       T   GE   ++C  +   P   + W
Sbjct: 506 RAKAQIVVTDPPPQ-------LVPAPNV-------TVSPGETAVLSCRVLGEAPYN-LTW 550

Query: 180 FKGNTELKGKS-EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLE 238
            +    L   +  V + +D+    S ++       DG    C   +    G  +   +L 
Sbjct: 551 VRDWRVLPASTGRVAQLADLSLEISGII-----PTDGGRYQCVASN--ANGVTRASVWLL 603

Query: 239 VQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA---VLSG 295
           V+  PQV I  +        +G  ++++C A G P P  ++W R    + + +   V + 
Sbjct: 604 VREAPQVSIHTS---SQHFSQGVEVKVSCSASGYPTP-HISWSRESQALQEDSRIHVDAQ 659

Query: 296 PNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
             L I  +   D G Y C+A+N VG       LY  DPP+
Sbjct: 660 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 699



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/225 (24%), Positives = 88/225 (39%), Gaps = 19/225 (8%)

Query: 113  NVSISDEGRYFCQ---LYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +V+  D+  Y C+   ++     E+   +T   PP+ +         +EG+ + + C  +
Sbjct: 851  SVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ-IASSAPTVRVLEGQPVSLPCIVL 909

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
            A +P     W K    L   S     +D       L L    ++      C   + A  G
Sbjct: 910  AGRPLPERHWLKDGRPLPPGSRHSIRAD-----GSLHLDRALQEHAGRYSCVATNTA--G 962

Query: 230  NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEM-- 287
            +      L VQ  P++H   T+ +   T EG    L C A G P P  +TW +  + +  
Sbjct: 963  SQHRDVELVVQVPPRIHPTATHHI---TNEGVPASLPCVASGVPAPT-ITWTKETNALTS 1018

Query: 288  --PQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYV 330
              P + V     L I   +  D G Y C A+N VG +  +  L V
Sbjct: 1019 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 58/249 (23%), Positives = 99/249 (39%), Gaps = 21/249 (8%)

Query: 104 SSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVE-GEEI 162
           SS  K+ +      D G Y C+   +    S   I + V     + ++ +D  VE G   
Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSA 803

Query: 163 EVNCTAMASKPATTIRWFKGNTEL------KGKSEVEEWSDMYTVTSQLMLKVHKEDDGV 216
            + C A   +P  T+ W +G+ +        G+       D    +  L  +    +D  
Sbjct: 804 LLACRA-TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD----SGVLFFESVAPEDQA 858

Query: 217 PVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAI-GKPQP 275
           P +C+  +  V G +Q +  L V       I  + P   +  EG  + L C  + G+P P
Sbjct: 859 PYVCEARN--VFGKVQAEARLIVTGHAPPQIASSAPTVRVL-EGQPVSLPCIVLAGRPLP 915

Query: 276 VMVTWVRVDDEMP---QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYD 332
               W++    +P   +H++ +  +L ++   +   G Y C A+N  G  H D  L V  
Sbjct: 916 ER-HWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 974

Query: 333 PPTTIPPPT 341
           PP   P  T
Sbjct: 975 PPRIHPTAT 983



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 60/233 (25%), Positives = 92/233 (39%), Gaps = 21/233 (9%)

Query: 108  KVSLTNVSISDEGRYFCQLYTDPPQE-SYTTITVLVPP--RNLMIDIQKDTAVEGEEIEV 164
            ++ + + S  D G Y C            T + V VPP   N + D+   +  EG    +
Sbjct: 4001 QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL---STTEGSHAFL 4057

Query: 165  NCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEH 224
             C A  S P   I W K    + G     E       + +L++K  +  D     C  E+
Sbjct: 4058 PCKARGS-PEPNITWDKDGQPVSGA----EGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 4112

Query: 225  PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
                G  + + +L +   P   +  T P     R GD L L C A G P P  + W  V+
Sbjct: 4113 --AVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWT-VN 4165

Query: 285  DEMPQHAVLS---GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            D      V     G  L    +++ D+GTY C A N VG+  +   ++V + P
Sbjct: 4166 DRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 4218



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 77/349 (22%), Positives = 135/349 (38%), Gaps = 47/349 (13%)

Query: 38   LIPT--GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS 95
            L PT  G  ++   ++VTV      ++ C+          L  P+    + +D  P + S
Sbjct: 2535 LAPTILGGAEDSADEEVTVTVNNPISLICEA---------LAFPSPNITWMKDGAPFEAS 2585

Query: 96   R-FQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT--ITVLVPPRNLMIDIQ 152
            R  QLL  +     + + N    D G+Y C + T+   E+     + VL+PP     D  
Sbjct: 2586 RNIQLLPGTHG---LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPPSISKDDPL 2641

Query: 153  KDTAVEGEEIEVNCTAMA-----SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLML 207
             +  V+  + +VN T        + P  TIRW+K    +   S ++   +       L +
Sbjct: 2642 GEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQI 2697

Query: 208  KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDA----- 262
            +  +  D    +C   + A   +      ++V    Q     +   + L+RE +A     
Sbjct: 2698 QPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVT 2757

Query: 263  ----------LELTCEAIGKPQPVMVTWVRVDDEMP---QHAVLSGPNLFINNLNKTDN- 308
                        L C+    P P + TW R D  +    + +VL G  +    L + +N 
Sbjct: 2758 EYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816

Query: 309  GTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTI 357
            G Y C+ASN VG+    Y L V  PP  +          T   ++ +++
Sbjct: 2817 GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 2865



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 55/193 (28%), Positives = 78/193 (40%), Gaps = 26/193 (13%)

Query: 156  AVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG 215
            AV  EE+ + C A +  P  TI W K     +G +     S       QL +     +D 
Sbjct: 3959 AVAEEEVLLPCEA-SGIPRPTITWQK-----EGLNVATGVSTQVLPGGQLRIAHASPEDA 4012

Query: 216  VPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGDALELTCEAIG 271
               +C  ++ A  G+   +  L VQ  P +         GL    T EG    L C+A G
Sbjct: 4013 GNYLCIAKNSA--GSAMGKTRLVVQVPPVIE-------NGLPDLSTTEGSHAFLPCKARG 4063

Query: 272  KPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYM 327
             P+P  +TW +    V     +  +     L + NL   D GTY C A N VG+A     
Sbjct: 4064 SPEP-NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122

Query: 328  LYVYDPP--TTIP 338
            L +   P  TT+P
Sbjct: 4123 LTILVLPVFTTLP 4135



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/179 (24%), Positives = 71/179 (39%), Gaps = 15/179 (8%)

Query: 159  GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
            G  I+++C      P   I W K    L+G     +  +       L +   + DD    
Sbjct: 4233 GGSIQLDCVVRGD-PVPDIHWIKDGLPLRGSHLRHQLQN-----GSLTIHRTERDDAGRY 4286

Query: 219  ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMV 278
             C  E+    G  +    L +Q  P   ++   P     R GD + L C+A G+P P  +
Sbjct: 4287 QCLAENEM--GVAKKVVILVLQSAPVFQVE---PQDMTVRSGDDVALRCQATGEPTPT-I 4340

Query: 279  TWVRVDDEMPQHA---VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             W++    +        L   +L++ N+   D GTY C A N++G A +   L V   P
Sbjct: 4341 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 57/231 (24%), Positives = 90/231 (38%), Gaps = 16/231 (6%)

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNCTA 168
            +T   + DEGRY C  ++   Q++    + V  PP     +   + AV E   +++ C A
Sbjct: 1467 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 1526

Query: 169  MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTS-QLMLKVHKEDDGVPVICQVEHPAV 227
                P   I WFK    L   ++V     +YT    QL L   +  D     C+  +   
Sbjct: 1527 RGV-PTPNITWFKDGALLPTSTKV-----VYTRGGRQLQLGRAQSSDAGVYTCKASN--A 1578

Query: 228  TGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW----VRV 283
             G  +    L+V   P +      P       G  + L C A G P P + +W    + V
Sbjct: 1579 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL-SWHHEGLPV 1637

Query: 284  DDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             +         G  L + +  +  +G Y C AS+  G+A   Y + V  PP
Sbjct: 1638 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPP 1688



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 6/96 (6%)

Query: 256  LTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHA--VLSGPNLFINNLNKTDNGT 310
            LT    AL L CEA G P+P++V W    ++D  + Q A  +L    L +      D+  
Sbjct: 3775 LTAHTPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 3833

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTT 346
            + C  SN VG+AH  Y + V+ PPT     T  T T
Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 3869



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 22/228 (9%)

Query: 118  DEGRYFCQLYTDP--PQESYTTITVLVPPRNLMIDIQKDT-AVEGEEIEVNCTAMASKPA 174
            D G Y C+        Q  +  + VL PP  L     ++   + G ++E+ C   +  P 
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLL-VLTPPSVLGAGAAQEVLGLAGADVELQCWT-SGVPT 1437

Query: 175  TTIRWFKGNTELKGKS---EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNL 231
              + W K    +       +V+E   +  +T       H  D+G    C    PA  G  
Sbjct: 1438 PQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS-----HVGDEG-RYQCVAFSPA--GQQ 1489

Query: 232  QTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA 291
                 L V   P +        +    E   ++L CEA G P P  +TW +    +P   
Sbjct: 1490 ARDFQLRVHAPPTIW-GSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDGALLPTST 1547

Query: 292  VL----SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
             +     G  L +     +D G Y C+ASN VG A     L VY PPT
Sbjct: 1548 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 1595



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 69/306 (22%), Positives = 118/306 (38%), Gaps = 54/306 (17%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            +TV EG   ++SC+             P  +  + +D +PL      L + S+    + L
Sbjct: 2172 LTVREGHPTSLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL 2222

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTT-ITVLVPPR-------NLMIDIQKDTAVEGEEIE 163
                ++ EG Y C+        S    + V VPP+          + + +D       +E
Sbjct: 2223 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT---LE 2279

Query: 164  VNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI-CQV 222
             N T    KP  T+ W +               D   V ++L L++  +   + V   Q 
Sbjct: 2280 CNATG---KPPPTVTWER---------------DGQPVGAELGLQLQNQGQSLHVERAQA 2321

Query: 223  EHPA--------VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTRE-GDALELTCEAIGKP 273
             H          + G  + +  L V   P++ I    PL  +T      L L CEA+G P
Sbjct: 2322 AHTGRYSCVAENLAGRAERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIP 2380

Query: 274  QPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             P  + W R ++ +      + +  G  L +    + D+G Y C ASN  G+A  ++ + 
Sbjct: 2381 PPA-IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 2439

Query: 330  VYDPPT 335
            V  PP+
Sbjct: 2440 VLVPPS 2445



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 73/344 (21%), Positives = 121/344 (35%), Gaps = 51/344 (14%)

Query: 18   AAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLL 77
            AA+P G+  R   L      ++   + QN    DV V+ G +  + C+       ++   
Sbjct: 3386 AASPAGVADRNFTLQVQVPPVLEPVEFQN----DVVVVRGSLVELPCEARGVPLPLVS-- 3439

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYT 136
                   + +D  PL     +          + L  V   D G Y C   ++  +   + 
Sbjct: 3440 -------WMKDGEPLLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 3486

Query: 137  TITVLVPPRNLMIDIQKDTAVE---GEEIEVNCTAMASKPATTIRWFKGN---TELKGKS 190
             +TV+ PP   + D  + T +    G  +E+ C A  + P   I W K     T L+  S
Sbjct: 3487 QLTVMEPPH--IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENNS 3543

Query: 191  EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMT 250
                             +V +  D     C  E PA  G ++    + VQ  P + +   
Sbjct: 3544 RAT--------------RVLRVRDAGLYTCLAESPA--GAIEKSFRVRVQAPPNI-VGPR 3586

Query: 251  YPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN----LFINNLNKT 306
             P   +      L L C    +P P  +TW R    + + A    P     L +  L+  
Sbjct: 3587 GPRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTA 3645

Query: 307  DNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTT 350
            D+G Y C A N  G     + + ++  PT    P     +   T
Sbjct: 3646 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 3689



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/89 (34%), Positives = 41/89 (46%), Gaps = 5/89 (5%)

Query: 265  LTCEAIGKPQPVMVTW----VRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            L C+A G P P +V+W    V +D   P+  +L   +L I  +   D G Y C ASN  G
Sbjct: 3692 LPCQADGVPAP-LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAG 3750

Query: 321  KAHSDYMLYVYDPPTTIPPPTTTTTTTTT 349
                   L V +PP   P P+  T T  T
Sbjct: 3751 SDRQGRDLRVLEPPAIAPSPSNLTLTAHT 3779



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 41/299 (13%)

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT- 136
            +P+    +  +  P+ +S    L    S L+  L +   +  G Y C + + P  E+   
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESRLETDGSVLR--LESPGEASSGLYSC-VASSPAGEAVLQ 1679

Query: 137  -TITVLVPPRNLMID-IQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEE 194
             ++ V VPP+ L+ + + + T + G+ +E+ C A  S P  TI+W      L+     EE
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS-PVPTIQW------LQNGRPAEE 1732

Query: 195  WSDMYTVTSQLMLKV-HKEDDGVPVI-CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYP 252
             + +   +    L + H E D   +  CQ  + A T   + +  +  ++ P V       
Sbjct: 1733 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 1792

Query: 253  LQGLTREGDALELTCEAI------GKPQPVMV-------------TWVRVDDEMPQHAVL 293
                     +    C+          P+P +V             T + V   +P     
Sbjct: 1793 YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP----- 1847

Query: 294  SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTT 352
              P L I  ++  D G Y C A+N+ G++  +  L V  PP   P P         + T
Sbjct: 1848 --PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT 1904



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 59/252 (23%), Positives = 93/252 (36%), Gaps = 33/252 (13%)

Query: 109  VSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTA--VEGEEIEVNC 166
            V    +  SD GRY C+       +++     ++ P +   D        V GE   + C
Sbjct: 1169 VHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPC 1228

Query: 167  TAMASKPATTIRWFKGNTE--LKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEH 224
             A  + P   + W KG +   L G+  V    +     S  +  V   D G    CQ  +
Sbjct: 1229 PARGT-PKPQVTWRKGPSSEPLHGQPGVAVLEE----GSLFLASVSPADSG-DYECQATN 1282

Query: 225  PAVTGNLQTQRYLEVQYKPQVHIQ-MTYPLQGLTREGDALELTCEAIGKPQPVMVT---- 279
                G+   +  L V   P +        + G+   G +L L C+A G P P +V     
Sbjct: 1283 EV--GSTSRRAKLVVYVPPSIREDGRKANVSGMA--GQSLTLECDANGFPVPEIVWLKDA 1338

Query: 280  -------------WVRVDDEMPQHAVLS-GPNLFINNLNKTDNGTYRCEASNIVGKAHSD 325
                         W     ++  H +L  G +L    + + D+G Y C A N  G A  D
Sbjct: 1339 QLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD 1398

Query: 326  YMLYVYDPPTTI 337
            + L V  PP+ +
Sbjct: 1399 FHLLVLTPPSVL 1410



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/138 (28%), Positives = 56/138 (40%), Gaps = 11/138 (7%)

Query: 208  KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTC 267
            KV   D+G+          + G  + +  L+V   P +      P+     E  ++ L C
Sbjct: 1854 KVDLRDEGIYTCAATN---LAGESKREVALKVLVPPNIE---PGPVNKAVLENASVTLEC 1907

Query: 268  EAIGKPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAH 323
             A G P P  V+W +    V   M     + G  L I     +D G+YRC ASN+ G   
Sbjct: 1908 LASGVPPPD-VSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 1966

Query: 324  SDYMLYVYDPPTTIPPPT 341
              Y L V  PP    PP+
Sbjct: 1967 LRYGLRVNVPPRITLPPS 1984



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 59/250 (23%), Positives = 96/250 (38%), Gaps = 46/250 (18%)

Query: 109  VSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNC 166
            + +T     D G Y C    +  +     ++ VLVPP     D+++   V +G+   + C
Sbjct: 2408 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 2467

Query: 167  TAMASKPATTIRWFKGNTEL-KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP 225
              +   P   + WFK    L +G +                   H   DGV +     + 
Sbjct: 2468 N-VTGHPQPKLTWFKDGRPLARGDAH------------------HISPDGVLLQVLQANL 2508

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREG--------------DALELTCEAIG 271
            +  G+        V  K + H Q++  L      G              + + L CEA+ 
Sbjct: 2509 SSAGHYSCIAANAVGEKTK-HFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA 2567

Query: 272  KPQPVMVTWVRVDDEMPQHA-----VLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSD 325
             P P  +TW++  D  P  A     +L G + L I N  K D G Y C  +N +G+A  +
Sbjct: 2568 FPSP-NITWMK--DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN 2624

Query: 326  YMLYVYDPPT 335
            Y + V  PP+
Sbjct: 2625 YHVEVLIPPS 2634



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 62/292 (21%), Positives = 96/292 (32%), Gaps = 62/292 (21%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            V V+EG+  ++ C        ++    P  +  + +D RPL       +    S   + L
Sbjct: 894  VRVLEGQPVSLPC--------IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS---LHL 942

Query: 112  TNVSISDEGRYFC-QLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMA 170
                    GRY C    T   Q     + V VPPR +          EG    + C A +
Sbjct: 943  DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR-IHPTATHHITNEGVPASLPCVA-S 1000

Query: 171  SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ--LMLKVHKEDDGVPVICQVEHPAVT 228
              PA TI W K    L  +         Y V+ +  L++      D    +C   +    
Sbjct: 1001 GVPAPTITWTKETNALTSRGP------HYNVSKEGTLLIAQPSAQDAGAYVCTATNTV-- 1052

Query: 229  GNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMP 288
                                      G + +   L +   A+ K       W        
Sbjct: 1053 --------------------------GFSSQEMRLSVNRLALSK-----YVW-------E 1074

Query: 289  QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPP 340
            ++ +L   +L +  +   D+G Y C ASN  G A   Y+L V  PP   P P
Sbjct: 1075 EYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGP 1126



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 37/162 (22%), Positives = 63/162 (38%), Gaps = 15/162 (9%)

Query: 85   YFRDFRPLKDS--RFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLV 142
            + +D  PL+ S  R QL N S     +++      D GRY C    +        I VL 
Sbjct: 4252 WIKDGLPLRGSHLRHQLQNGS-----LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ 4306

Query: 143  PPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
                  ++ Q  T   G+++ + C A   +P  TI W +    L+    +    D     
Sbjct: 4307 SAPVFQVEPQDMTVRSGDDVALRCQA-TGEPTPTIEWLQAGQPLRASRRLRTLPD----- 4360

Query: 203  SQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
              L L+  +  D     C   +  + G+   + +L V+ +PQ
Sbjct: 4361 GSLWLENVETGDAGTYDCVAHN--LLGSATARAFLVVRGEPQ 4400



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)

Query: 265  LTCEAIGKPQPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            LTC + G P P  V+W +   ++      + V     L I        G Y C A N  G
Sbjct: 3876 LTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 3934

Query: 321  KAHSDYMLYVYDPPTTIPPPT 341
             AH    L V   P   P P+
Sbjct: 3935 VAHKHVFLTVQASPVVKPLPS 3955



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 14/58 (24%), Positives = 25/58 (43%)

Query: 304 NKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDS 361
           +K + GTY C A +  G   +   + V DPP  + P    T +   T      ++ ++
Sbjct: 487 SKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 66/286 (23%), Positives = 117/286 (40%), Gaps = 22/286 (7%)

Query: 79  PNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTI 138
           P+   ++ +D  P+  +    L        ++L +   SD GRY C   +   ++    +
Sbjct: 723 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 782

Query: 139 TVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDM 198
             +  P +++ +    + V  E + + C + A  P   + W+K    L+ +  V   +D 
Sbjct: 783 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRPGVHLSAD- 840

Query: 199 YTVTSQLMLKVHKED--DGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL 256
                + +L+V + D  D     C+  + A  G+ +    L V   P   ++ ++ L   
Sbjct: 841 -----KALLQVDRADVWDAGHYTCEALNQA--GHSEKHYNLNVWVAPVFPLRESHTLT-- 891

Query: 257 TREGDALELTCEAIGKPQPVMVTWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGT 310
            REG    L+CE  G P P  ++W +    +P      QH    G  L++        GT
Sbjct: 892 VREGHPTRLSCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950

Query: 311 YRCEASNIVGKAHSDYMLYVYDPPTTIPP--PTTTTTTTTTTTTTI 354
           Y CE SN+VG +  D  L V+ PP    P  P T  +       T+
Sbjct: 951 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 996



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 86/313 (27%), Positives = 122/313 (38%), Gaps = 32/313 (10%)

Query: 42   GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS-RFQLL 100
            GD + L  ++VTV      ++ C           L NP     + ++  P   S R Q+L
Sbjct: 1564 GDTEEL-VEEVTVNASSTVSLQCPA---------LGNPVPTISWLQNGLPFSPSPRLQVL 1613

Query: 101  NFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEG 159
                  L+VS   V+  D   Y C         E   T+ V VPPR   +D+++ TA+  
Sbjct: 1614 E-DGQVLQVSTAEVA--DAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1670

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
              + + C   A  P   + W+K +  L    EV     +   T  L L   +  D     
Sbjct: 1671 SSVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVF----LLPGTHTLQLGRARLSDSGMYT 1725

Query: 220  CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQG-LTREGDALELTCEAIGKPQPVMV 278
            C+  + A  G  Q    L V   P        P    L R GD   L+CE    P+P  V
Sbjct: 1726 CEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 1782

Query: 279  TWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYD 332
            TW +  D  P        A+  G  L I     +D G Y C+ SN+ G+A   + L V  
Sbjct: 1783 TWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV 1840

Query: 333  PPTTIPPPTTTTT 345
            PPT   P T T +
Sbjct: 1841 PPTFENPKTETVS 1853



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 74/305 (24%), Positives = 121/305 (39%), Gaps = 21/305 (6%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            F  A L+      +   ++  V+EG+   + C+ +           P     + +D  PL
Sbjct: 1926 FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQ---------PPPDVAWLKDGSPL 1976

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDI 151
                   L F      + L  +  SD G Y C  +    +++   T+ VLVPP       
Sbjct: 1977 GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGAD 2036

Query: 152  QKDTAVE--GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKV 209
               T V   GE + + C    S P   + W K    L            +T+    + KV
Sbjct: 2037 GSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLR---ISKV 2092

Query: 210  HKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEA 269
               D G+   C    PA  G       L+VQ  P +   + +    +   G  +EL CEA
Sbjct: 2093 QLADAGI-FTCVAASPA--GVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEA 2148

Query: 270  IGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             G P P +V+W++  + +   ++  GP+L +  +   D+GTY C A +  G+A   + L 
Sbjct: 2149 RGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207

Query: 330  VYDPP 334
            V +PP
Sbjct: 2208 VMEPP 2212



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 78/314 (24%), Positives = 115/314 (36%), Gaps = 28/314 (8%)

Query: 51   DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
            +V+V+  E   + CQ +     V+          +++D RPL+      ++ S+ +  + 
Sbjct: 797  NVSVVANESVALECQSHAMPPPVLS---------WWKDGRPLEPRPG--VHLSADKALLQ 845

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    + D G Y C+        E +  + V V P   + +    T  EG    ++C   
Sbjct: 846  VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECR 905

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
               P   I W K    L G  E      +  V   L L   +        C+  +  V G
Sbjct: 906  GV-PFPKISWRKDGQPLPG--EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN--VVG 960

Query: 230  NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQ 289
            N      LEV   PQ+      P Q    +     L C A GKP P  VTW R  D  P 
Sbjct: 961  NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT-VTWER--DGQPV 1017

Query: 290  HAVLS------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP--PPT 341
             A L       G +L +        G Y C A N+ G+A   + L V  PP  I    P 
Sbjct: 1018 GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL 1077

Query: 342  TTTTTTTTTTTTIL 355
            T  T    +  T+L
Sbjct: 1078 TNITAALHSPLTLL 1091



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 59/239 (24%), Positives = 101/239 (42%), Gaps = 24/239 (10%)

Query: 109 VSLTNVSISDEGRYFCQLYTDPPQESYTTIT--VLVPPRNLMIDIQKDTAVEGEEIEVNC 166
           + +  V + DEG Y C   T+   ES   +   VLVPP N+         +E   + + C
Sbjct: 568 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPP-NIEPGPVNKAVLENASVTLEC 625

Query: 167 TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKED--DGVPVICQVEH 224
            A +  P   + WFKG+        V  W  +       +L++ +    D     C   +
Sbjct: 626 LA-SGVPPPDVSWFKGH------QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN 678

Query: 225 PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
             V G+ + +  L V   P++ +  + P  G       + LTC A G P P ++ W++  
Sbjct: 679 --VAGSTELRYGLRVNVPPRITLPPSLP--GPVLVNTPVRLTCNATGAPSPTLM-WLKDG 733

Query: 285 DEM-----PQHAVLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
           + +     P   V  G   L + +   +D+G Y C A + VG+   D +L V+ PP+ +
Sbjct: 734 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 792



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 70/317 (22%), Positives = 127/317 (40%), Gaps = 36/317 (11%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            FS   L+P         + + V++G+ A + C V           +P  +  +F+D RPL
Sbjct: 1154 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG---------HPQPKLTWFKDGRPL 1204

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQES-YTTITVLVPPRNLMIDI 151
              +R    + S   + + +   ++S  G Y C       +++ +  ++VL+ P   ++  
Sbjct: 1205 --ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT--ILGG 1260

Query: 152  QKDTAVEGEEIEVN------CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQL 205
             +D+A E   + VN      C A+A  P+  I W K     +    ++     + +    
Sbjct: 1261 AEDSADEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQ--- 1316

Query: 206  MLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGD 261
            +L   KED G    C V +    G      ++EV   P +         G+    T+   
Sbjct: 1317 ILNAQKEDAG-QYTCVVTNEL--GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS 1373

Query: 262  ALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS----GPNLFINNLNKTDNGTYRCEASN 317
             L L CE+   P P  + W +    +   + L     G  L I     +D+G Y C A+N
Sbjct: 1374 TLTLECESWAVPPPT-IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432

Query: 318  IVGKAHSDYMLYVYDPP 334
            + G+   D+ + +  PP
Sbjct: 1433 VAGEDDQDFNVLIQVPP 1449



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 68/300 (22%), Positives = 120/300 (40%), Gaps = 23/300 (7%)

Query: 45   QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSS 104
            +N  T+ V+ + G    ++C V+           P     + +D  P++ S        S
Sbjct: 1845 ENPKTETVSQVAGSPLVLTCDVSGV---------PAPTVTWLKDRMPVESSAVH--GVVS 1893

Query: 105  SELKVSLTNVSISDEGRYFCQLY-TDPPQESYTTITVLVPPRNLMIDIQKDTAV-EGEEI 162
               ++ L+ +  +  G Y C    T         + VLV PR     + ++  V EG+E+
Sbjct: 1894 RGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEV 1953

Query: 163  EVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
             ++C A   +P   + W K  + L    ++      Y     L+LK  +  D     C  
Sbjct: 1954 RLDCEA-DGQPPPDVAWLKDGSPLG--QDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 2010

Query: 223  EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
             +PA  G       + V   P +          ++R G+ + + C   G P P+ V+W++
Sbjct: 2011 HNPA--GEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSWLK 2067

Query: 283  VDDEMP--QHAVL--SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
                +P  Q  +L  SG  L I+ +   D G + C A++  G A  ++ L V  PP   P
Sbjct: 2068 DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEP 2127



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 77/300 (25%), Positives = 121/300 (40%), Gaps = 45/300 (15%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLK-DSRFQLLNFSSSELKVS 110
            V V  G+ A +SC+ +           P     +++D +PL    R Q L       ++ 
Sbjct: 1760 VLVRVGDKAVLSCETDAL---------PEPTVTWYKDGQPLVLAQRTQALRGGQ---RLE 1807

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    +SD+G Y C++     +   T T+TV VPP       +  + V G  + + C  +
Sbjct: 1808 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD-V 1866

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ---LMLKVHKEDDGVPVICQVEHPA 226
            +  PA T+ W      LK +  VE  S ++ V S+   L L   +        C  E+  
Sbjct: 1867 SGVPAPTVTW------LKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-- 1917

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALE-----LTCEAIGKPQPVMVTWV 281
                  TQ      +   V +       G+ RE   LE     L CEA G+P P  V W+
Sbjct: 1918 ------TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWL 1970

Query: 282  R----VDDEMPQHA--VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            +    +  +M  H    L G +L +  L  +D G Y C A N  G+    + + V  PPT
Sbjct: 1971 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPT 2030



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 76/312 (24%), Positives = 120/312 (38%), Gaps = 37/312 (11%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL-KDSRFQLLNFSSSELKVS 110
            V+V++  VAT+ C              P     + RD +P+  +   QL N   S   + 
Sbjct: 986  VSVVQDGVATLECNATGK---------PPPTVTWERDGQPVGAELGLQLQNQGQS---LH 1033

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNL--MIDIQKDTAVEGEEIEVNCT 167
            +     +  GRY C       + E    ++VLVPP  +  +  +   TA     + + C 
Sbjct: 1034 VERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCE 1093

Query: 168  AMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHK--EDDGVPVICQVEHP 225
            AM   P   IRWF+G      +  V    D Y +    MLK+ +  E D     C   + 
Sbjct: 1094 AMGIPPPA-IRWFRG------EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 1146

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTR--EGDALELTCEAIGKPQPVMVTWVRV 283
            A  G  +    +EV   P +  +    L+ + +  +G    L C   G PQP + TW + 
Sbjct: 1147 A--GEARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKL-TWFKD 1200

Query: 284  DDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
               + +    H    G  L +   N +  G Y C A+N VG+    + L V   PT +  
Sbjct: 1201 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1260

Query: 340  PTTTTTTTTTTT 351
               +     T T
Sbjct: 1261 AEDSADEEVTVT 1272



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 86/335 (25%), Positives = 130/335 (38%), Gaps = 41/335 (12%)

Query: 9   GSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNK 68
           G +      A +P G + R   L   A    PT  G N  T +V V+E  +  + C+   
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAP---PTIWGSNE-TGEVAVMEDHLVQLLCEARG 246

Query: 69  SDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYT 128
                     P     +F+D   L  S   +      +L+  L     SD G Y C+   
Sbjct: 247 V---------PTPNITWFKDGALLPTSTKVVYTRGGRQLQ--LGRAQSSDAGVYTCKASN 295

Query: 129 DP-PQESYTTITVLVPP-------RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180
                E  T + V VPP       R  ++      AV G  + + C A    P+ T+ W 
Sbjct: 296 AVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGH-PSPTLSWH 349

Query: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240
                +   +E    S + T  S L L+   E       C    PA  G    Q  +EVQ
Sbjct: 350 HEGLPVAESNE----SRLETDGSVLRLESPGEASSGLYSCVASSPA--GEAVLQYSVEVQ 403

Query: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHAVLS-GP 296
             PQ+ +      Q  T  G  LEL C+A G P P  + W+   R  +E+    V S G 
Sbjct: 404 VPPQLLVAEGLG-QVTTIVGQPLELPCQASGSPVPT-IQWLQNGRPAEELAGVQVASQGT 461

Query: 297 NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
            L I+++    +G + C+A+N  G A ++  + V+
Sbjct: 462 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 496



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 60/233 (25%), Positives = 92/233 (39%), Gaps = 21/233 (9%)

Query: 108  KVSLTNVSISDEGRYFCQLYTDPPQE-SYTTITVLVPP--RNLMIDIQKDTAVEGEEIEV 164
            ++ + + S  D G Y C            T + V VPP   N + D+   +  EG    +
Sbjct: 2719 QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL---STTEGSHAFL 2775

Query: 165  NCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEH 224
             C A  S P   I W K    + G     E       + +L++K  +  D     C  E+
Sbjct: 2776 PCKARGS-PEPNITWDKDGQPVSGA----EGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2830

Query: 225  PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
                G  + + +L +   P   +  T P     R GD L L C A G P P  + W  V+
Sbjct: 2831 --AVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWT-VN 2883

Query: 285  DEMPQHAVLS---GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            D      V     G  L    +++ D+GTY C A N VG+  +   ++V + P
Sbjct: 2884 DRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 2936



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 44/179 (24%), Positives = 72/179 (40%), Gaps = 15/179 (8%)

Query: 159  GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
            G  I+++C      P   I W K    L+G     +  +       L ++  + DD    
Sbjct: 2951 GGSIQLDCVVRGD-PVPDIHWIKDGLPLRGSHLRHQLQN-----GSLTIRRTERDDAGRY 3004

Query: 219  ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMV 278
             C  E+    G  +    L +Q  P   ++   P     R GD + L C+A G+P P  +
Sbjct: 3005 QCLAENEM--GVAKKVVILVLQSAPVFQVE---PQDMTVRSGDDVALRCQATGEPTPT-I 3058

Query: 279  TWVRVDDEMPQHA---VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             W++    +        L   +L++ N+   D GTY C A N++G A +   L V   P
Sbjct: 3059 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 77/349 (22%), Positives = 135/349 (38%), Gaps = 47/349 (13%)

Query: 38   LIPT--GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS 95
            L PT  G  ++   ++VTV      ++ C+          L  P+    + +D  P + S
Sbjct: 1253 LAPTILGGAEDSADEEVTVTVNNPISLICEA---------LAFPSPNITWMKDGAPFEAS 1303

Query: 96   R-FQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT--ITVLVPPRNLMIDIQ 152
            R  QLL  +     + + N    D G+Y C + T+   E+     + VL+PP     D  
Sbjct: 1304 RNIQLLPGTHG---LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPPSISKDDPL 1359

Query: 153  KDTAVEGEEIEVNCTAMA-----SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLML 207
             +  V+  + +VN T        + P  TIRW+K    +   S ++   +       L +
Sbjct: 1360 AEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQI 1415

Query: 208  KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDA----- 262
            +  +  D    +C   + A   +      ++V    Q     +   + L+RE +A     
Sbjct: 1416 QPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVT 1475

Query: 263  ----------LELTCEAIGKPQPVMVTWVRVDDEMP---QHAVLSGPNLFINNLNKTDN- 308
                        L C+    P P + TW R D  +    + +VL G  +    L + +N 
Sbjct: 1476 EYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1534

Query: 309  GTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTI 357
            G Y C+ASN VG+    Y L V  PP  +          T   ++ +++
Sbjct: 1535 GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1583



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 55/193 (28%), Positives = 78/193 (40%), Gaps = 26/193 (13%)

Query: 156  AVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG 215
            AV  EE+ + C A +  P  TI W K     +G +     S       QL +     +D 
Sbjct: 2677 AVAEEEVLLPCEA-SGIPRPTITWQK-----EGLNVATGVSTQVLPGGQLRIAHASPEDA 2730

Query: 216  VPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGDALELTCEAIG 271
               +C  ++ A  G+   +  L VQ  P +         GL    T EG    L C+A G
Sbjct: 2731 GNYLCIAKNSA--GSAMGKTRLVVQVPPVIE-------NGLPDLSTTEGSHAFLPCKARG 2781

Query: 272  KPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYM 327
             P+P  +TW +    V     +  +     L + NL   D GTY C A N VG+A     
Sbjct: 2782 SPEP-NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840

Query: 328  LYVYDPP--TTIP 338
            L +   P  TT+P
Sbjct: 2841 LTILVLPVFTTLP 2853



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 57/231 (24%), Positives = 90/231 (38%), Gaps = 16/231 (6%)

Query: 111 LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNCTA 168
           +T   + DEGRY C  ++   Q++    + V  PP     +   + AV E   +++ C A
Sbjct: 185 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 244

Query: 169 MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTS-QLMLKVHKEDDGVPVICQVEHPAV 227
               P   I WFK    L   ++V     +YT    QL L   +  D     C+  +   
Sbjct: 245 RGV-PTPNITWFKDGALLPTSTKV-----VYTRGGRQLQLGRAQSSDAGVYTCKASN--A 296

Query: 228 TGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW----VRV 283
            G  +    L+V   P +      P       G  + L C A G P P + +W    + V
Sbjct: 297 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL-SWHHEGLPV 355

Query: 284 DDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            +         G  L + +  +  +G Y C AS+  G+A   Y + V  PP
Sbjct: 356 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPP 406



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 6/96 (6%)

Query: 256  LTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHA--VLSGPNLFINNLNKTDNGT 310
            LT    AL L CEA G P+P++V W    ++D  + Q A  +L    L +      D+  
Sbjct: 2493 LTAHTPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2551

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTT 346
            + C  SN VG+AH  Y + V+ PPT     T  T T
Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 2587



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 22/228 (9%)

Query: 118 DEGRYFCQLYTDP--PQESYTTITVLVPPRNLMIDIQKDT-AVEGEEIEVNCTAMASKPA 174
           D G Y C+        Q  +  + VL PP  L     ++   + G ++E+ C   +  P 
Sbjct: 98  DSGLYSCRAENQAGTAQRDFHLL-VLTPPSVLGAGAAQEVLGLAGADVELQCWT-SGVPT 155

Query: 175 TTIRWFKGNTELKGKS---EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNL 231
             + W K    +       +V+E   +  +T       H  D+G    C    PA  G  
Sbjct: 156 PQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS-----HVGDEG-RYQCVAFSPA--GQQ 207

Query: 232 QTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHA 291
                L V   P +        +    E   ++L CEA G P P  +TW +    +P   
Sbjct: 208 ARDFQLRVHAPPTIW-GSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDGALLPTST 265

Query: 292 VL----SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            +     G  L +     +D G Y C+ASN VG A     L VY PPT
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 73/344 (21%), Positives = 121/344 (35%), Gaps = 51/344 (14%)

Query: 18   AAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLL 77
            AA+P G+  R   L      ++   + QN    DV V+ G +  + C+       ++   
Sbjct: 2104 AASPAGVADRNFTLQVQVPPVLEPVEFQN----DVVVVRGSLVELPCEARGVPLPLVS-- 2157

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYT 136
                   + +D  PL     +          + L  V   D G Y C   ++  +   + 
Sbjct: 2158 -------WMKDGEPLLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 2204

Query: 137  TITVLVPPRNLMIDIQKDTAVE---GEEIEVNCTAMASKPATTIRWFKGN---TELKGKS 190
             +TV+ PP   + D  + T +    G  +E+ C A  + P   I W K     T L+  S
Sbjct: 2205 QLTVMEPPH--IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENNS 2261

Query: 191  EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMT 250
                             +V +  D     C  E PA  G ++    + VQ  P + +   
Sbjct: 2262 RAT--------------RVLRVRDAGLYTCLAESPA--GAIEKSFRVRVQAPPNI-VGPR 2304

Query: 251  YPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN----LFINNLNKT 306
             P   +      L L C    +P P  +TW R    + + A    P     L +  L+  
Sbjct: 2305 GPRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTA 2363

Query: 307  DNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTT 350
            D+G Y C A N  G     + + ++  PT    P     +   T
Sbjct: 2364 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 2407



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/89 (34%), Positives = 41/89 (46%), Gaps = 5/89 (5%)

Query: 265  LTCEAIGKPQPVMVTW----VRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            L C+A G P P +V+W    V +D   P+  +L   +L I  +   D G Y C ASN  G
Sbjct: 2410 LPCQADGVPAP-LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAG 2468

Query: 321  KAHSDYMLYVYDPPTTIPPPTTTTTTTTT 349
                   L V +PP   P P+  T T  T
Sbjct: 2469 SDRQGRDLRVLEPPAIAPSPSNLTLTAHT 2497



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 69/306 (22%), Positives = 117/306 (38%), Gaps = 54/306 (17%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            +TV EG    +SC+             P  +  + +D +PL      L + S+    + L
Sbjct: 890  LTVREGHPTRLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL 940

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTT-ITVLVPPR-------NLMIDIQKDTAVEGEEIE 163
                ++ EG Y C+        S    + V VPP+          + + +D       +E
Sbjct: 941  GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT---LE 997

Query: 164  VNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI-CQV 222
             N T    KP  T+ W +               D   V ++L L++  +   + V   Q 
Sbjct: 998  CNATG---KPPPTVTWER---------------DGQPVGAELGLQLQNQGQSLHVERAQA 1039

Query: 223  EHPA--------VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTRE-GDALELTCEAIGKP 273
             H          + G  + +  L V   P++ I    PL  +T      L L CEA+G P
Sbjct: 1040 AHTGRYSCVAENLAGRAERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIP 1098

Query: 274  QPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             P  + W R ++ +      + +  G  L +    + D+G Y C ASN  G+A  ++ + 
Sbjct: 1099 PPA-IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1157

Query: 330  VYDPPT 335
            V  PP+
Sbjct: 1158 VLVPPS 1163



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 41/299 (13%)

Query: 78  NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT- 136
           +P+    +  +  P+ +S    L    S L+  L +   +  G Y C + + P  E+   
Sbjct: 341 HPSPTLSWHHEGLPVAESNESRLETDGSVLR--LESPGEASSGLYSC-VASSPAGEAVLQ 397

Query: 137 -TITVLVPPRNLMID-IQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEE 194
            ++ V VPP+ L+ + + + T + G+ +E+ C A  S P  TI+W      L+     EE
Sbjct: 398 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS-PVPTIQW------LQNGRPAEE 450

Query: 195 WSDMYTVTSQLMLKV-HKEDDGVPVI-CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYP 252
            + +   +    L + H E D   +  CQ  + A T   + +  +  ++ P V       
Sbjct: 451 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 510

Query: 253 LQGLTREGDALELTCEAI------GKPQPVMV-------------TWVRVDDEMPQHAVL 293
                    +    C+          P+P +V             T + V   +P     
Sbjct: 511 YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP----- 565

Query: 294 SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTT 352
             P L I  ++  D G Y C A+N+ G++  +  L V  PP   P P         + T
Sbjct: 566 --PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT 622



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/138 (28%), Positives = 56/138 (40%), Gaps = 11/138 (7%)

Query: 208 KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTC 267
           KV   D+G+          + G  + +  L+V   P +      P+     E  ++ L C
Sbjct: 572 KVDLRDEGIYTCAATN---LAGESKREVALKVLVPPNIE---PGPVNKAVLENASVTLEC 625

Query: 268 EAIGKPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAH 323
            A G P P  V+W +    V   M     + G  L I     +D G+YRC ASN+ G   
Sbjct: 626 LASGVPPPD-VSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 684

Query: 324 SDYMLYVYDPPTTIPPPT 341
             Y L V  PP    PP+
Sbjct: 685 LRYGLRVNVPPRITLPPS 702



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 67/288 (23%), Positives = 108/288 (37%), Gaps = 49/288 (17%)

Query: 109  VSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNC 166
            + +T     D G Y C    +  +     ++ VLVPP     D+++   V +G+   + C
Sbjct: 1126 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1185

Query: 167  TAMASKPATTIRWFKGNTEL-KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP 225
              +   P   + WFK    L +G +                   H   DGV +     + 
Sbjct: 1186 N-VTGHPQPKLTWFKDGRPLARGDAH------------------HISPDGVLLQVLQANL 1226

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREG--------------DALELTCEAIG 271
            +  G+        V  K + H Q++  L      G              + + L CEA+ 
Sbjct: 1227 SSAGHYSCIAANAVGEKTK-HFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA 1285

Query: 272  KPQPVMVTWVRVDDEMPQHA-----VLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSD 325
             P P  +TW++  D  P  A     +L G + L I N  K D G Y C  +N +G+A  +
Sbjct: 1286 FPSP-NITWMK--DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN 1342

Query: 326  YMLYVYDPPTTI---PPPTTTTTTTTTTTTTILTIITDSRAGEEGSIR 370
            Y + V  PP+     P          T   + LT+  +S A    +IR
Sbjct: 1343 YHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 27/96 (28%), Positives = 40/96 (41%), Gaps = 18/96 (18%)

Query: 260 GDALELTCEAIGKPQPVMVT-----------------WVRVDDEMPQHAVLS-GPNLFIN 301
           G +L L C+A G P P +V                  W     ++  H +L  G +L   
Sbjct: 33  GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92

Query: 302 NLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
            + + D+G Y C A N  G A  D+ L V  PP+ +
Sbjct: 93  RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVL 128



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 37/162 (22%), Positives = 63/162 (38%), Gaps = 15/162 (9%)

Query: 85   YFRDFRPLKDS--RFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLV 142
            + +D  PL+ S  R QL N S     +++      D GRY C    +        I VL 
Sbjct: 2970 WIKDGLPLRGSHLRHQLQNGS-----LTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQ 3024

Query: 143  PPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
                  ++ Q  T   G+++ + C A   +P  TI W +    L+    +    D     
Sbjct: 3025 SAPVFQVEPQDMTVRSGDDVALRCQA-TGEPTPTIEWLQAGQPLRASRRLRTLPD----- 3078

Query: 203  SQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
              L L+  +  D     C   +  + G+   + +L V+ +PQ
Sbjct: 3079 GSLWLENVETGDAGTYDCVAHN--LLGSATARAFLVVRGEPQ 3118



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)

Query: 265  LTCEAIGKPQPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            LTC + G P P  V+W +   ++      + V     L I        G Y C A N  G
Sbjct: 2594 LTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 2652

Query: 321  KAHSDYMLYVYDPPTTIPPPT 341
             AH    L V   P   P P+
Sbjct: 2653 VAHKHVFLTVQASPVVKPLPS 2673


>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
          Length = 344

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 80/308 (25%), Positives = 134/308 (43%), Gaps = 42/308 (13%)

Query: 39  IPTGDGQNLFTK---DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTI-YFRDFRPLKD 94
           +P   G   F K   +VTV +GE AT+ C +   D+ V ++   NR TI Y  + +   D
Sbjct: 29  VPVRSGDATFPKAMDNVTVRQGESATLRCTI---DNRVTRVAWLNRSTILYAGNDKWCLD 85

Query: 95  SRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTD-PPQESYTTITVLVPPRNLMIDIQK 153
            R  LL+ + ++  + + NV + DEG Y C + TD  P+ S   + V V P+  +++I  
Sbjct: 86  PRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK--IVEISS 143

Query: 154 DTAV-EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVH-- 210
           D ++ EG  I + C A   +P  T+ W   + +  G    +E+ ++  +T +        
Sbjct: 144 DISINEGNNISLTCIA-TGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECS 202

Query: 211 -KEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL-TREGDALELTCE 268
              D   PV+ +V+             + V Y P +        +G     G    L CE
Sbjct: 203 ASNDVAAPVVRRVK-------------VTVNYPPYIS-----EAKGTGVPVGQKGTLQCE 244

Query: 269 AIGKPQPVMVTWVRVDDEMPQH----AVLSGP---NLFINNLNKTDNGTYRCEASNIVGK 321
           A   P      W + D  + +      V + P    L   N+++ D G Y C ASN +G 
Sbjct: 245 ASAVPS-AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGH 303

Query: 322 AHSDYMLY 329
            ++  ML+
Sbjct: 304 TNASIMLF 311


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 66/286 (23%), Positives = 116/286 (40%), Gaps = 22/286 (7%)

Query: 79   PNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTI 138
            P+   ++ +D  P+  +    L        ++L +   SD GRY C   +   ++    +
Sbjct: 814  PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873

Query: 139  TVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDM 198
              +  P +++ +    + V  E + + C + A  P   + W+K    L+ +  V   +D 
Sbjct: 874  LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRPGVHLSAD- 931

Query: 199  YTVTSQLMLKVHKED--DGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL 256
                 + +L+V + D  D     C+  + A  G  +    L V   P   ++ ++ L   
Sbjct: 932  -----KALLQVDRADVWDAGHYTCEALNQA--GRSEKHYNLNVWVAPVFPLRESHTLT-- 982

Query: 257  TREGDALELTCEAIGKPQPVMVTWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGT 310
             REG    L+CE  G P P  ++W +    +P      QH    G  L++        GT
Sbjct: 983  VREGHPTSLSCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPP--PTTTTTTTTTTTTTI 354
            Y CE SN+VG +  D  L V+ PP    P  P T  +       T+
Sbjct: 1042 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL 1087



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 86/313 (27%), Positives = 122/313 (38%), Gaps = 32/313 (10%)

Query: 42   GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS-RFQLL 100
            GD + L  ++VTV      ++ C           L NP     + ++  P   S R Q+L
Sbjct: 1655 GDTEEL-VEEVTVNASSTVSLQCPA---------LGNPVPTISWLQNGLPFSPSPRLQVL 1704

Query: 101  NFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEG 159
                  L+VS   V+  D   Y C         E   T+ V VPPR   +D+++ TA+  
Sbjct: 1705 E-DGQVLQVSTAEVA--DAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1761

Query: 160  EEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI 219
              + + C   A  P   + W+K +  L    EV     +   T  L L   +  D     
Sbjct: 1762 SSVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVF----LLPGTHTLQLGRARLSDSGMYT 1816

Query: 220  CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQG-LTREGDALELTCEAIGKPQPVMV 278
            C+  + A  G  Q    L V   P        P    L R GD   L+CE    P+P  V
Sbjct: 1817 CEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 1873

Query: 279  TWVRVDDEMP------QHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYD 332
            TW +  D  P        A+  G  L I     +D G Y C+ SN+ G+A   + L V  
Sbjct: 1874 TWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV 1931

Query: 333  PPTTIPPPTTTTT 345
            PPT   P T T +
Sbjct: 1932 PPTFENPKTETVS 1944



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 74/305 (24%), Positives = 121/305 (39%), Gaps = 21/305 (6%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            F  A L+      +   ++  V+EG+   + C+ +           P     + +D  PL
Sbjct: 2017 FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQ---------PPPDVAWLKDGSPL 2067

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDI 151
                   L F      + L  +  SD G Y C  +    +++   T+ VLVPP       
Sbjct: 2068 GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGAD 2127

Query: 152  QKDTAVE--GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKV 209
               T V   GE + + C    S P   + W K    L            +T+    + KV
Sbjct: 2128 GSGTLVSRPGELVTMVCPVRGSPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLR---ISKV 2183

Query: 210  HKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEA 269
               D G+   C    PA  G       L+VQ  P +   + +    +   G  +EL CEA
Sbjct: 2184 QLADAGI-FTCVAASPA--GVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEA 2239

Query: 270  IGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             G P P +V+W++  + +   ++  GP+L +  +   D+GTY C A +  G+A   + L 
Sbjct: 2240 RGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298

Query: 330  VYDPP 334
            V +PP
Sbjct: 2299 VMEPP 2303



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 78/314 (24%), Positives = 116/314 (36%), Gaps = 28/314 (8%)

Query: 51   DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
            +V+V+  E   + CQ +     V+          +++D RPL+      ++ S+ +  + 
Sbjct: 888  NVSVVANESVALECQSHAMPPPVLS---------WWKDGRPLEPRPG--VHLSADKALLQ 936

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    + D G Y C+      + E +  + V V P   + +    T  EG    ++C   
Sbjct: 937  VDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECR 996

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTG 229
               P   I W K    L G  E      +  V   L L   +        C+  +  V G
Sbjct: 997  GV-PFPKISWRKDGQPLPG--EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN--VVG 1051

Query: 230  NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQ 289
            N      LEV   PQ+      P Q    +     L C A GKP P  VTW R  D  P 
Sbjct: 1052 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT-VTWER--DGQPV 1108

Query: 290  HAVLS------GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP--PPT 341
             A L       G +L +        G Y C A N+ G+A   + L V  PP  I    P 
Sbjct: 1109 GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL 1168

Query: 342  TTTTTTTTTTTTIL 355
            T  T    +  T+L
Sbjct: 1169 TNITAALHSPLTLL 1182



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 59/239 (24%), Positives = 101/239 (42%), Gaps = 24/239 (10%)

Query: 109 VSLTNVSISDEGRYFCQLYTDPPQESYTTIT--VLVPPRNLMIDIQKDTAVEGEEIEVNC 166
           + +  V + DEG Y C   T+   ES   +   VLVPP N+         +E   + + C
Sbjct: 659 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPP-NIEPGPVNKAVLENASVTLEC 716

Query: 167 TAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKED--DGVPVICQVEH 224
            A +  P   + WFKG+        V  W  +       +L++ +    D     C   +
Sbjct: 717 LA-SGVPPPDVSWFKGH------QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN 769

Query: 225 PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
             V G+ + +  L V   P++ +  + P  G       + LTC A G P P ++ W++  
Sbjct: 770 --VAGSTELRYGLRVNVPPRITLPPSLP--GPVLVNTPVRLTCNATGAPSPTLM-WLKDG 824

Query: 285 DEM-----PQHAVLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI 337
           + +     P   V  G   L + +   +D+G Y C A + VG+   D +L V+ PP+ +
Sbjct: 825 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 883



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 70/317 (22%), Positives = 127/317 (40%), Gaps = 36/317 (11%)

Query: 33   FSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL 92
            FS   L+P         + + V++G+ A + C V           +P  +  +F+D RPL
Sbjct: 1245 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG---------HPQPKLTWFKDGRPL 1295

Query: 93   KDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQES-YTTITVLVPPRNLMIDI 151
              +R    + S   + + +   ++S  G Y C       +++ +  ++VL+ P   ++  
Sbjct: 1296 --ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT--ILGG 1351

Query: 152  QKDTAVEGEEIEVN------CTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQL 205
             +D+A E   + VN      C A+A  P+  I W K     +    ++     + +    
Sbjct: 1352 AEDSADEEVTVTVNNPISLICEALAF-PSPNITWMKDGAPFEASRNIQLLPGTHGLQ--- 1407

Query: 206  MLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGD 261
            +L   KED G    C V +    G      ++EV   P +         G+    T+   
Sbjct: 1408 ILNAQKEDAG-QYTCVVTNEL--GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 1464

Query: 262  ALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLS----GPNLFINNLNKTDNGTYRCEASN 317
             L L CE+   P P  + W +    +   + L     G  L I     +D+G Y C A+N
Sbjct: 1465 TLTLECESWAVPPPT-IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 318  IVGKAHSDYMLYVYDPP 334
            + G+   D+ + +  PP
Sbjct: 1524 VAGEDDQDFNVLIQVPP 1540



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 68/300 (22%), Positives = 120/300 (40%), Gaps = 23/300 (7%)

Query: 45   QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSS 104
            +N  T+ V+ + G    ++C V+           P     + +D  P++ S        S
Sbjct: 1936 ENPKTETVSQVAGSPLVLTCDVSGV---------PAPTVTWLKDRMPVESSAVH--GVVS 1984

Query: 105  SELKVSLTNVSISDEGRYFCQLY-TDPPQESYTTITVLVPPRNLMIDIQKDTAV-EGEEI 162
               ++ L+ +  +  G Y C    T         + VLV PR     + ++  V EG+E+
Sbjct: 1985 RGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEV 2044

Query: 163  EVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
             ++C A   +P   + W K  + L    ++      Y     L+LK  +  D     C  
Sbjct: 2045 RLDCEA-DGQPPPDVAWLKDGSPLG--QDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 2101

Query: 223  EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
             +PA  G       + V   P +          ++R G+ + + C   G P P+ V+W++
Sbjct: 2102 HNPA--GEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSWLK 2158

Query: 283  VDDEMP--QHAVL--SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIP 338
                +P  Q  +L  SG  L I+ +   D G + C A++  G A  ++ L V  PP   P
Sbjct: 2159 DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEP 2218



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 77/300 (25%), Positives = 121/300 (40%), Gaps = 45/300 (15%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLK-DSRFQLLNFSSSELKVS 110
            V V  G+ A +SC+ +           P     +++D +PL    R Q L       ++ 
Sbjct: 1851 VLVRVGDKAVLSCETDAL---------PEPTVTWYKDGQPLVLAQRTQALRGGQ---RLE 1898

Query: 111  LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAM 169
            +    +SD+G Y C++     +   T T+TV VPP       +  + V G  + + C  +
Sbjct: 1899 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD-V 1957

Query: 170  ASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQ---LMLKVHKEDDGVPVICQVEHPA 226
            +  PA T+ W      LK +  VE  S ++ V S+   L L   +        C  E+  
Sbjct: 1958 SGVPAPTVTW------LKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-- 2008

Query: 227  VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALE-----LTCEAIGKPQPVMVTWV 281
                  TQ      +   V +       G+ RE   LE     L CEA G+P P  V W+
Sbjct: 2009 ------TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWL 2061

Query: 282  R----VDDEMPQHA--VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPT 335
            +    +  +M  H    L G +L +  L  +D G Y C A N  G+    + + V  PPT
Sbjct: 2062 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPT 2121



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 76/312 (24%), Positives = 120/312 (38%), Gaps = 37/312 (11%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPL-KDSRFQLLNFSSSELKVS 110
            V+V++  VAT+ C              P     + RD +P+  +   QL N   S   + 
Sbjct: 1077 VSVVQDGVATLECNATGK---------PPPTVTWERDGQPVGAELGLQLQNQGQS---LH 1124

Query: 111  LTNVSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNL--MIDIQKDTAVEGEEIEVNCT 167
            +     +  GRY C       + E    ++VLVPP  +  +  +   TA     + + C 
Sbjct: 1125 VERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCE 1184

Query: 168  AMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHK--EDDGVPVICQVEHP 225
            AM   P   IRWF+G      +  V    D Y +    MLK+ +  E D     C   + 
Sbjct: 1185 AMGIPPPA-IRWFRG------EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 1237

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTR--EGDALELTCEAIGKPQPVMVTWVRV 283
            A  G  +    +EV   P +  +    L+ + +  +G    L C   G PQP + TW + 
Sbjct: 1238 A--GEARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKL-TWFKD 1291

Query: 284  DDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPP 339
               + +    H    G  L +   N +  G Y C A+N VG+    + L V   PT +  
Sbjct: 1292 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1351

Query: 340  PTTTTTTTTTTT 351
               +     T T
Sbjct: 1352 AEDSADEEVTVT 1363



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 86/335 (25%), Positives = 130/335 (38%), Gaps = 41/335 (12%)

Query: 9   GSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNK 68
           G +      A +P G + R   L   A    PT  G N  T +V V+E  +  + C+   
Sbjct: 282 GDEGRYQCVAFSPAGQQARDFQLRVHAP---PTIWGSNE-TGEVAVMEDHLVQLLCEARG 337

Query: 69  SDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYT 128
                     P     +F+D   L  S   +      +L+  L     SD G Y C+   
Sbjct: 338 V---------PTPNITWFKDGALLPTSTKVVYTRGGRQLQ--LGRAQSSDAGVYTCKASN 386

Query: 129 DP-PQESYTTITVLVPP-------RNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF 180
                E  T + V VPP       R  ++      AV G  + + C A    P+ T+ W 
Sbjct: 387 AVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGH-PSPTLSWH 440

Query: 181 KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQ 240
                +   +E    S + T  S L L+   E       C    PA  G    Q  +EVQ
Sbjct: 441 HEGLPVAESNE----SRLETDGSVLRLESPGEASSGLYSCVASSPA--GEAVLQYSVEVQ 494

Query: 241 YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHAVLS-GP 296
             PQ+ +      Q  T  G  LEL C+A G P P  + W+   R  +E+    V S G 
Sbjct: 495 VPPQLLVAEGLG-QVTTIVGQPLELPCQASGSPVPT-IQWLQNGRPAEELAGVQVASQGT 552

Query: 297 NLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
            L I+++    +G + C+A+N  G A ++  + V+
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 587



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 60/233 (25%), Positives = 92/233 (39%), Gaps = 21/233 (9%)

Query: 108  KVSLTNVSISDEGRYFCQLYTDPPQE-SYTTITVLVPP--RNLMIDIQKDTAVEGEEIEV 164
            ++ + + S  D G Y C            T + V VPP   N + D+   +  EG    +
Sbjct: 2810 QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL---STTEGSHAFL 2866

Query: 165  NCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEH 224
             C A  S P   I W K    + G     E       + +L++K  +  D     C  E+
Sbjct: 2867 PCKARGS-PEPNITWDKDGQPVSGA----EGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2921

Query: 225  PAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVD 284
                G  + + +L +   P   +  T P     R GD L L C A G P P  + W  V+
Sbjct: 2922 --AVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWT-VN 2974

Query: 285  DEMPQHAVLS---GPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            D      V     G  L    +++ D+GTY C A N VG+  +   ++V + P
Sbjct: 2975 DRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 3027



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 77/349 (22%), Positives = 135/349 (38%), Gaps = 47/349 (13%)

Query: 38   LIPT--GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDS 95
            L PT  G  ++   ++VTV      ++ C+          L  P+    + +D  P + S
Sbjct: 1344 LAPTILGGAEDSADEEVTVTVNNPISLICEA---------LAFPSPNITWMKDGAPFEAS 1394

Query: 96   R-FQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTT--ITVLVPPRNLMIDIQ 152
            R  QLL  +     + + N    D G+Y C + T+   E+     + VL+PP     D  
Sbjct: 1395 RNIQLLPGTHG---LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPPSISKDDPL 1450

Query: 153  KDTAVEGEEIEVNCTAMA-----SKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLML 207
             +  V+  + +VN T        + P  TIRW+K    +   S ++   +       L +
Sbjct: 1451 GEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQI 1506

Query: 208  KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDA----- 262
            +  +  D    +C   + A   +      ++V    Q     +   + L+RE +A     
Sbjct: 1507 QPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVT 1566

Query: 263  ----------LELTCEAIGKPQPVMVTWVRVDDEMP---QHAVLSGPNLFINNLNKTDN- 308
                        L C+    P P + TW R D  +    + +VL G  +    L + +N 
Sbjct: 1567 EYREIVENNPAYLYCDTNAIPPPDL-TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1625

Query: 309  GTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTI 357
            G Y C+ASN VG+    Y L V  PP  +          T   ++ +++
Sbjct: 1626 GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1674



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 55/193 (28%), Positives = 78/193 (40%), Gaps = 26/193 (13%)

Query: 156  AVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG 215
            AV  EE+ + C A +  P  TI W K     +G +     S       QL +     +D 
Sbjct: 2768 AVAEEEVLLPCEA-SGIPRPTITWQK-----EGLNVATGVSTQVLPGGQLRIAHASPEDA 2821

Query: 216  VPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGL----TREGDALELTCEAIG 271
               +C  ++ A  G+   +  L VQ  P +         GL    T EG    L C+A G
Sbjct: 2822 GNYLCIAKNSA--GSAMGKTRLVVQVPPVIE-------NGLPDLSTTEGSHAFLPCKARG 2872

Query: 272  KPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYM 327
             P+P  +TW +    V     +  +     L + NL   D GTY C A N VG+A     
Sbjct: 2873 SPEP-NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931

Query: 328  LYVYDPP--TTIP 338
            L +   P  TT+P
Sbjct: 2932 LTILVLPVFTTLP 2944



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/179 (24%), Positives = 71/179 (39%), Gaps = 15/179 (8%)

Query: 159  GEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV 218
            G  I+++C      P   I W K    L+G     +  +       L +   + DD    
Sbjct: 3042 GGSIQLDCVVRGD-PVPDIHWIKDGLPLRGSHLRHQLQN-----GSLTIHRTERDDAGRY 3095

Query: 219  ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMV 278
             C  E+    G  +    L +Q  P   ++   P     R GD + L C+A G+P P  +
Sbjct: 3096 QCLAENEM--GVAKKVVILVLQSAPVFQVE---PQDMTVRSGDDVALRCQATGEPTPT-I 3149

Query: 279  TWVRVDDEMPQHA---VLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
             W++    +        L   +L++ N+   D GTY C A N++G A +   L V   P
Sbjct: 3150 EWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 57/231 (24%), Positives = 90/231 (38%), Gaps = 16/231 (6%)

Query: 111 LTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNCTA 168
           +T   + DEGRY C  ++   Q++    + V  PP     +   + AV E   +++ C A
Sbjct: 276 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335

Query: 169 MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTS-QLMLKVHKEDDGVPVICQVEHPAV 227
               P   I WFK    L   ++V     +YT    QL L   +  D     C+  +   
Sbjct: 336 RGV-PTPNITWFKDGALLPTSTKV-----VYTRGGRQLQLGRAQSSDAGVYTCKASN--A 387

Query: 228 TGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTW----VRV 283
            G  +    L+V   P +      P       G  + L C A G P P + +W    + V
Sbjct: 388 VGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL-SWHHEGLPV 446

Query: 284 DDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP 334
            +         G  L + +  +  +G Y C AS+  G+A   Y + V  PP
Sbjct: 447 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPP 497



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 6/96 (6%)

Query: 256  LTREGDALELTCEAIGKPQPVMVTWV---RVDDEMPQHA--VLSGPNLFINNLNKTDNGT 310
            LT    AL L CEA G P+P++V W    ++D  + Q A  +L    L +      D+  
Sbjct: 2584 LTAHTPAL-LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2642

Query: 311  YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTT 346
            + C  SN VG+AH  Y + V+ PPT     T  T T
Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 2678



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 69/306 (22%), Positives = 118/306 (38%), Gaps = 54/306 (17%)

Query: 52   VTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSL 111
            +TV EG   ++SC+             P  +  + +D +PL      L + S+    + L
Sbjct: 981  LTVREGHPTSLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL 1031

Query: 112  TNVSISDEGRYFCQLYTDPPQESYTT-ITVLVPPR-------NLMIDIQKDTAVEGEEIE 163
                ++ EG Y C+        S    + V VPP+          + + +D       +E
Sbjct: 1032 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVAT---LE 1088

Query: 164  VNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVI-CQV 222
             N T    KP  T+ W +               D   V ++L L++  +   + V   Q 
Sbjct: 1089 CNATG---KPPPTVTWER---------------DGQPVGAELGLQLQNQGQSLHVERAQA 1130

Query: 223  EHPA--------VTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTRE-GDALELTCEAIGKP 273
             H          + G  + +  L V   P++ I    PL  +T      L L CEA+G P
Sbjct: 1131 AHTGRYSCVAENLAGRAERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIP 1189

Query: 274  QPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLY 329
             P  + W R ++ +      + +  G  L +    + D+G Y C ASN  G+A  ++ + 
Sbjct: 1190 PPA-IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1248

Query: 330  VYDPPT 335
            V  PP+
Sbjct: 1249 VLVPPS 1254



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 73/344 (21%), Positives = 121/344 (35%), Gaps = 51/344 (14%)

Query: 18   AAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLL 77
            AA+P G+  R   L      ++   + QN    DV V+ G +  + C+       ++   
Sbjct: 2195 AASPAGVADRNFTLQVQVPPVLEPVEFQN----DVVVVRGSLVELPCEARGVPLPLVS-- 2248

Query: 78   NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQ-ESYT 136
                   + +D  PL     +          + L  V   D G Y C   ++  +   + 
Sbjct: 2249 -------WMKDGEPLLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 2295

Query: 137  TITVLVPPRNLMIDIQKDTAVE---GEEIEVNCTAMASKPATTIRWFKGN---TELKGKS 190
             +TV+ PP   + D  + T +    G  +E+ C A  + P   I W K     T L+  S
Sbjct: 2296 QLTVMEPPH--IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENNS 2352

Query: 191  EVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMT 250
                             +V +  D     C  E PA  G ++    + VQ  P + +   
Sbjct: 2353 RAT--------------RVLRVRDAGLYTCLAESPA--GAIEKSFRVRVQAPPNI-VGPR 2395

Query: 251  YPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPN----LFINNLNKT 306
             P   +      L L C    +P P  +TW R    + + A    P     L +  L+  
Sbjct: 2396 GPRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTA 2454

Query: 307  DNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTT 350
            D+G Y C A N  G     + + ++  PT    P     +   T
Sbjct: 2455 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 2498



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/89 (34%), Positives = 41/89 (46%), Gaps = 5/89 (5%)

Query: 265  LTCEAIGKPQPVMVTW----VRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            L C+A G P P +V+W    V +D   P+  +L   +L I  +   D G Y C ASN  G
Sbjct: 2501 LPCQADGVPAP-LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAG 2559

Query: 321  KAHSDYMLYVYDPPTTIPPPTTTTTTTTT 349
                   L V +PP   P P+  T T  T
Sbjct: 2560 SDRQGRDLRVLEPPAIAPSPSNLTLTAHT 2588



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 6/74 (8%)

Query: 267 CEAIGKPQPVMVTWVRVDDEMPQH-----AVLSGPNLFINNLNKTDNGTYRCEASNIVGK 321
           C   G P+P  VTW +     P H     AVL   +LF+ +++  D+G Y C+A+N VG 
Sbjct: 24  CGTHGTPKP-QVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82

Query: 322 AHSDYMLYVYDPPT 335
                 L VY PP+
Sbjct: 83  TSRRAKLVVYVPPS 96



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 259 EGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVL----SGPNLFINNLNKTDNGTYRCE 314
           E   ++L CEA G P P  +TW +    +P    +     G  L +     +D G Y C+
Sbjct: 325 EDHLVQLLCEARGVPTP-NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 383

Query: 315 ASNIVGKAHSDYMLYVYDPPT 335
           ASN VG A     L VY PPT
Sbjct: 384 ASNAVGAAEKATRLDVYVPPT 404



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 41/299 (13%)

Query: 78  NPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYT- 136
           +P+    +  +  P+ +S    L    S L+  L +   +  G Y C + + P  E+   
Sbjct: 432 HPSPTLSWHHEGLPVAESNESRLETDGSVLR--LESPGEASSGLYSC-VASSPAGEAVLQ 488

Query: 137 -TITVLVPPRNLMID-IQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEE 194
            ++ V VPP+ L+ + + + T + G+ +E+ C A  S P  TI+W      L+     EE
Sbjct: 489 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS-PVPTIQW------LQNGRPAEE 541

Query: 195 WSDMYTVTSQLMLKV-HKEDDGVPVI-CQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYP 252
            + +   +    L + H E D   +  CQ  + A T   + +  +  ++ P V       
Sbjct: 542 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 601

Query: 253 LQGLTREGDALELTCEAI------GKPQPVMV-------------TWVRVDDEMPQHAVL 293
                    +    C+          P+P +V             T + V   +P     
Sbjct: 602 YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP----- 656

Query: 294 SGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTT 352
             P L I  ++  D G Y C A+N+ G++  +  L V  PP   P P         + T
Sbjct: 657 --PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT 713



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/138 (28%), Positives = 56/138 (40%), Gaps = 11/138 (7%)

Query: 208 KVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTC 267
           KV   D+G+          + G  + +  L+V   P +      P+     E  ++ L C
Sbjct: 663 KVDLRDEGIYTCAATN---LAGESKREVALKVLVPPNIE---PGPVNKAVLENASVTLEC 716

Query: 268 EAIGKPQPVMVTWVR----VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAH 323
            A G P P  V+W +    V   M     + G  L I     +D G+YRC ASN+ G   
Sbjct: 717 LASGVPPPD-VSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 775

Query: 324 SDYMLYVYDPPTTIPPPT 341
             Y L V  PP    PP+
Sbjct: 776 LRYGLRVNVPPRITLPPS 793



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 59/250 (23%), Positives = 96/250 (38%), Gaps = 46/250 (18%)

Query: 109  VSLTNVSISDEGRYFCQLYTDPPQESYT-TITVLVPPRNLMIDIQKDTAV-EGEEIEVNC 166
            + +T     D G Y C    +  +     ++ VLVPP     D+++   V +G+   + C
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1276

Query: 167  TAMASKPATTIRWFKGNTEL-KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP 225
              +   P   + WFK    L +G +                   H   DGV +     + 
Sbjct: 1277 N-VTGHPQPKLTWFKDGRPLARGDAH------------------HISPDGVLLQVLQANL 1317

Query: 226  AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREG--------------DALELTCEAIG 271
            +  G+        V  K + H Q++  L      G              + + L CEA+ 
Sbjct: 1318 SSAGHYSCIAANAVGEKTK-HFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA 1376

Query: 272  KPQPVMVTWVRVDDEMPQHA-----VLSGPN-LFINNLNKTDNGTYRCEASNIVGKAHSD 325
             P P  +TW++  D  P  A     +L G + L I N  K D G Y C  +N +G+A  +
Sbjct: 1377 FPSP-NITWMK--DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN 1433

Query: 326  YMLYVYDPPT 335
            Y + V  PP+
Sbjct: 1434 YHVEVLIPPS 1443



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 37/162 (22%), Positives = 63/162 (38%), Gaps = 15/162 (9%)

Query: 85   YFRDFRPLKDS--RFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLV 142
            + +D  PL+ S  R QL N S     +++      D GRY C    +        I VL 
Sbjct: 3061 WIKDGLPLRGSHLRHQLQNGS-----LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ 3115

Query: 143  PPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVT 202
                  ++ Q  T   G+++ + C A   +P  TI W +    L+    +    D     
Sbjct: 3116 SAPVFQVEPQDMTVRSGDDVALRCQA-TGEPTPTIEWLQAGQPLRASRRLRTLPD----- 3169

Query: 203  SQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQ 244
              L L+  +  D     C   +  + G+   + +L V+ +PQ
Sbjct: 3170 GSLWLENVETGDAGTYDCVAHN--LLGSATARAFLVVRGEPQ 3209



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 42/174 (24%), Positives = 68/174 (39%), Gaps = 17/174 (9%)

Query: 260 GDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKT---------DNGT 310
           G  +EL C   G P P  V W +  D  P   +  GP+L +    +          D G 
Sbjct: 232 GADVELQCWTSGVPTP-QVEWTK--DRQP--VLPGGPHLQVQEDGQVLRITGSHVGDEGR 286

Query: 311 YRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIR 370
           Y+C A +  G+   D+ L V+ PPT     +  T         ++ ++ ++R     +I 
Sbjct: 287 YQCVAFSPAGQQARDFQLRVHAPPTIW--GSNETGEVAVMEDHLVQLLCEARGVPTPNIT 344

Query: 371 AVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAI 424
                 +      VV+      + LGR  +   G Y T +A  A  AA+  T +
Sbjct: 345 WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY-TCKASNAVGAAEKATRL 397



 Score = 33.1 bits (74), Expect = 0.52
 Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)

Query: 265  LTCEAIGKPQPVMVTWVRVDDEMPQ----HAVLSGPNLFINNLNKTDNGTYRCEASNIVG 320
            LTC + G P P  V+W +   ++      + V     L I        G Y C A N  G
Sbjct: 2685 LTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG 2743

Query: 321  KAHSDYMLYVYDPPTTIPPPT 341
             AH    L V   P   P P+
Sbjct: 2744 VAHKHVFLTVQASPVVKPLPS 2764


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 80/309 (25%), Positives = 129/309 (41%), Gaps = 50/309 (16%)

Query: 51  DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
           DV V  GE A + CQ  +              TIY++  +   D + + ++    +L +S
Sbjct: 157 DVVVAAGEPAILECQPPRGHPE---------PTIYWKKDKVRIDDKEERISIRGGKLMIS 207

Query: 111 LTNVSISDEGRYFC-------QLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIE 163
             N   SD G Y C       +  +DP +     +TV   P  L   I +   +E E +E
Sbjct: 208 --NTRKSDAGMYTCVGTNMVGERDSDPAE-----LTVFERPTFLRRPINQ-VVLEEEAVE 259

Query: 164 VNCTAMASKPATTIRWFKGNTEL-KGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQV 222
             C      P  T+RW K + +L +G+ +++   D YT+  +   K    D+G   +C  
Sbjct: 260 FRCQVQGD-PQPTVRWKKDDADLPRGRYDIK---DDYTLRIK---KTMSTDEGT-YMCIA 311

Query: 223 EHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR 282
           E+    G ++    L V+  PQ  ++   P   +  +G  +   CE  G PQP  V W +
Sbjct: 312 ENRV--GKMEASATLTVRAPPQFVVR---PRDQIVAQGRTVTFPCETKGNPQPA-VFWQK 365

Query: 283 VDDE------MPQH-----AVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY 331
              +       PQ      +V    +L I N+ ++D G Y C+A  + G   +   L V 
Sbjct: 366 EGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT 425

Query: 332 DPPTTIPPP 340
           D  T  PPP
Sbjct: 426 DVLTDRPPP 434



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 74/311 (23%), Positives = 115/311 (36%), Gaps = 26/311 (8%)

Query: 51  DVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVS 110
           DV V +GE  T++C+        I+      +    +D    +  R  L + S   L++ 
Sbjct: 55  DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD--DPRSHRMLLPSGSLFFLRIV 112

Query: 111 LTNVSISDEGRYFC--QLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTA 168
               S  DEG Y C  + Y         ++ V +   +   +        GE   + C  
Sbjct: 113 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQP 172

Query: 169 MASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVT 228
               P  TI W K    +  K E      +     +LM+   ++ D     C      V 
Sbjct: 173 PRGHPEPTIYWKKDKVRIDDKEE-----RISIRGGKLMISNTRKSDAGMYTC------VG 221

Query: 229 GNLQTQR-----YLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRV 283
            N+  +R      L V  +P     +  P+  +  E +A+E  C+  G PQP  V W + 
Sbjct: 222 TNMVGERDSDPAELTVFERPTF---LRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKD 277

Query: 284 DDEMPQ--HAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPT 341
           D ++P+  + +     L I     TD GTY C A N VGK  +   L V  PP  +  P 
Sbjct: 278 DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 337

Query: 342 TTTTTTTTTTT 352
                   T T
Sbjct: 338 DQIVAQGRTVT 348



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 76/324 (23%), Positives = 130/324 (40%), Gaps = 42/324 (12%)

Query: 54  VIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTN 113
           V+E E     CQV       ++         + +D   L   R+ + +  +  +K +++ 
Sbjct: 252 VLEEEAVEFRCQVQGDPQPTVR---------WKKDDADLPRGRYDIKDDYTLRIKKTMS- 301

Query: 114 VSISDEGRYFCQLYTDPPQ-ESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASK 172
              +DEG Y C       + E+  T+TV  PP+  ++  +     +G  +   C    + 
Sbjct: 302 ---TDEGTYMCIAENRVGKMEASATLTVRAPPQ-FVVRPRDQIVAQGRTVTFPCETKGN- 356

Query: 173 PATTIRWFK-GNTELKGKSEVEEWSDMYTV--TSQLMLKVHKEDDGVPVICQVEHPAVTG 229
           P   + W K G+  L   ++ ++ +   +V  T  L +   +  D    ICQ     V G
Sbjct: 357 PQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQAL--TVAG 414

Query: 230 NLQTQRYLEVQY----KPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVR--- 282
           ++  +  LEV      +P   I      Q L  +G AL L C+A G P PV ++W++   
Sbjct: 415 SILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKATGDPLPV-ISWLKEGF 472

Query: 283 -VDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTI---- 337
                 P+  +     L I NL  +D GTY C A++  G+     +L V +   TI    
Sbjct: 473 TFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNY 532

Query: 338 -------PPPTTTTTTTTTTTTTI 354
                  PP     T  T  + T+
Sbjct: 533 DLSDLPGPPSKPQVTDVTKNSVTL 556



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/214 (28%), Positives = 94/214 (43%), Gaps = 28/214 (13%)

Query: 143 PPRNLMIDIQKDTAV-EGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTV 201
           PPR  +++   D  V +GE   +NC A   +P  TI W+K    ++   +      M   
Sbjct: 46  PPR--IVEHPSDVIVSKGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 102

Query: 202 TSQLMLK--VH----KEDDGVPVICQVEH---PAVTGNLQTQRYLEVQYKPQVHIQMTYP 252
           +  L     VH    K D+G   +C   +    AV+ N      LEV        Q   P
Sbjct: 103 SGSLFFLRIVHGRRSKPDEG-SYVCVARNYLGEAVSRNAS----LEVALLRDDFRQN--P 155

Query: 253 LQGLTREGDALELTCEAI-GKPQPVMVTW----VRVDDEMPQHAVLSGPNLFINNLNKTD 307
              +   G+   L C+   G P+P  + W    VR+DD+  + ++  G  L I+N  K+D
Sbjct: 156 TDVVVAAGEPAILECQPPRGHPEPT-IYWKKDKVRIDDKEERISIRGG-KLMISNTRKSD 213

Query: 308 NGTYRCEASNIVGKAHSD-YMLYVYDPPTTIPPP 340
            G Y C  +N+VG+  SD   L V++ PT +  P
Sbjct: 214 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRP 247


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,745,416
Number of Sequences: 37866
Number of extensions: 815373
Number of successful extensions: 9887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 4868
Number of HSP's gapped (non-prelim): 4061
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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